ENSGT00530000063191 : Linker Region Query Results

-----------------------------------------MENILSFL-----NRYIEP
---WLGFG---STFLNTGSNYIFLSGVGS-------ILLYLWYLI-LKPFFPPP------
------------------WKSQDIKKWQGTA--NKGR-----------------------
---------------------------------------------RSL----KGC--RTS
---QK--K--IQ-EQRKL------------------------------------------
----LSVVQSPIGE---LYDSS-RF--------------------RQLLCPDPFCDVCNG
ATA-K------INRL-LFQAT-PQDGT--ASMSS---MDS---T VSV----TE------T
LSLPLPENTVGDLISDPTYEPSL------QSSSIIPPH-QSVHLEDTLS-ASPLDDC--L
LPE--SP---VNAECPLDHD-----SLHPLASFSLPQQHAT---QETEL-LLQPATVLSL
VGSP----------WELFNDVPINEGI-CSSDHAVSE-----------------------
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---------F-IQQQTDT---GN---SSQL-----EPAHSDNQELL--DLHS-PESYLW-
GNTTTYLTLSG--N-LNFSSL-GTMALF-ETQD-G------GM-------TDSL------
-------------------------------------KT-W--G-----KTSE--FDHQN
LAVS-------HPLGSSK-------------------------E---RHHMP QKLPYSKT
SE-DQLEDKHTQFFCGLPS-LHSESMKSIAT-VLTDSSL-----TSGCCN----------
----------------RLLDSPVLTHH----TTLP---------LPKSQ-LT--------
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--------------NFSQSLSQSQ----YQPIPQANPQAQLQ-----SPIPVLSP-SL--
-SQHK-----ICGVYFHSP-QDEAQPLDPSAI----------------------------
--------------------HCLEYNI------LKKEQE---RVWGLPTVVKNSQQEFCP
PPPKPSLVTQ-----PSKIHVPRSIS--LENCLITIELRKKFEHHLRKRLILQC-----W
GL-PKRI-RESLSWMNPQGEL-------------------PELCPS-K--SNYG----LS
W------------------ISFFKQHGRKDLHNIVDTILNQ-PGSFPAKQL--------E
-KKLL--KAK-GHSLETV--------QKQQTWS----NT-KGTLD-NGLQF-DCEINLQC
P--------SDSPSCKPSG-----TSEVSRCQ-KKLETSLKEHLTI-HLNETNEGQIT-S
TMFRSRHGPF----------PFTSC------------D-KQ------EHEAQ-------M
PSDN--KGGLVKSTS---------------------------------------------
---------------------------------TV----K-----KSVLHT---------
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RPVE---S-E-GNRYNSDVP----RMLAEVGSVPLGKRLNSGKTVQSSQVTKMIDK---K
AFVSNKV-----------G-------KGGQLSSLQP------------------------
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-----------E-QRRKL------------------------------------------
----QTIQRSPPRE---PSDAS-CD--------------------ELLPHGGPLFPVCDR
S-G-D------VGHQ-LSQAI-LKDGA--ASHFY---V---TSTAPV----TE---ASFI
LSSLLTGRQPGHPAPAGPQEPLP------LAQSILSPN-CFAPLEGFHS-TALLHDS--L
TPESALP---LNPKPLPDPT-----PPYPFPSFPLPK-KEV---QKSEA-VFRPETARSL
VDGP----------NEVSVNVPLVKGT-GYVRQAMPA-----------------------
------------------------------------------------------------
---------A-SPRQPAA---DN---QLSS-----GLDN---QRPP--PTHV-SQASLQ-
KETRAYHLEPG--Q-LFSPNS-DALKLL-KRLD-Q------KG-------RDFLMAK-EE
-----------------------------------------------------------K
LPLGKSLVEPQDLAASHS------------------------AR---SKVTHQQLPHSRT
SE-DHEELKPAQLFWGPPS-LHSEALRPTT--SLYDRSS-----TFVCFN----------
----------SIAEASIADYSHAILLP----TPLS---------VY--G-SQ--------
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--------------TWLQPEPQSH----PTCDPLAESQPQPQLQY--PVSVLTLAPSQ--
-SELR-----YCGVHFHRP-QGDEQALGPSAT----------------------------
--------------------QCLEYNI------LKKEQE---RVWGLPLVIKKSQNAFCP
SPPKFLSASR-----SSKACTPRPIL--PGDFPLTGELQKKLEHHLRKRLIQRR-----W
GL-PHRI-DESLSLMCPQPEQ-------------------TDISES-R--RSRG----LS
K------------------TPFSKSHGNKDSKA---IGPGG-AGGFLSRMPEGHSL---Q
QEILV--KEQ-TYSQDTG--------QNDRPQG----NLQEAP----------QKTQPES
Q--------EGRQPGKLSS-----PSQVH--Q-KGIENILEEHLIR-KMREISGGEIP-S
AVDRSRH-----------------------------------------------------
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----------------------------------------MMENPLFFL-----KSVSAT
---WLSTS---STSWAMDMILAFACGLVL-------FHLLIPFFE-TNPSFPLT------
-------------------GKKNTRKHHIEKKGWKRKR------KKSC------------
----------------------------------------------IL----KAF--REC
RRE-------LE-ETRHLVL-LLQ------------------------------------
---------SLLHK---LPGNA--------------------------------------
--E-V------NHLSHG--D----------------------------------------
-----------------------------------AP E-PQEDQ----------------
------------------------------------------------------------
-----------------------------------------------------------P
AL-RK--LPTDTGP-----HDSQLSK----SCLASL--ISFLSGPD-LL-HHCLSC----
--------FS-WCWATAK---AT---FFSS-----WAHGKSQQEHL--SPHP-PDTVLW-
EGPAHWHAEMGRGD-HAFIHP-DVHKLL-EMLI-S------KR-------VKQKMLQ-E-
KP--KGGSFFELVN-----------------TDHP-RVS-L--R-----NLLKSLGDKL-
-TSA-------QPFCSTKGK----------------------AE---WLLGS QQPSLHKV
LG-SPLERECSLLFWGLPS-LHSESLVATAW-AGERSSST--RSHCIKFNEAHT------
-----------------------------------------------HI-PGPSLQDSPL
V-------LPSVQ-----------------------------------------------
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------------------------------------PPAQLL-----CFPPKPQPTSP--
-SQVR-----ACGTTCSTS-QKKAQSFLPIEN----------------------------
--------------------QDLEWTL-------QKPLK---WRQALNSKLQKAQEPISL
PTLNLPQGSQ-----ASEAPQSFSML--SG-DSCSAVLEKKPECHRPGRFNRDEGSENLP
HP-AFRF-Q---TPMQPPGKL-------------------PSKCQG-Q--AHDSHGPTQH
T-K----------------HSVPACNSSRDVQK---TKSWHCGT-LLNKGSVNLNL---K
--ERS--NV--LPEANKG---------QEDTSQ----ST-E------SPLP----KDAES
D--------TIWSEEYNSRSH----FSRDPDQ-KILGRGLQAHPSR-KLGQISEGIIP-A
CVRTACLTAN---HTL--P---KSNALSQPT-KTRCSKSGE------ISVNASQEVAFPD
PKTRILLEAHIMKYRLRHNWGPL-FQNLEHRNSH---------IAQAQASPPTEPPLVSS
ASC---DSRADFITKL--------------------------------------------
----------------------------AISEEEIPEKVLGKRETAQMLS--L-PLQSPL
PATRSSAWKEVQR-SGT-----GTPSDHNDGPSD-IPPTAQEVGLPS--AAC-------T
QQSS---TVLRIERGS--PWP--TPGLAMAKHDPGEGTGMVAFRGTCHSTP-MLE-----
-----IKLLSPLSV----AKESRK-LEVEE-R--HPAWEVTIGASMMENSQN-INISLR-
SFGSQDTS-NHS-SP-------SNQAPNVGRKVECQLDIKRHRERENWPQDVSSDNRQ--
-----------------------------D-CHAEGLLSTGTWPSQAS-LSRSQCTPHSH
TPTS-QFPCDR---SMNGESC--RGQ-H-EPSMSGFQDTE--------------------
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----------------------------KS-NK--MFGPTTQS-------KYYRK--PGK
EEESF-AGVRPPCDQELSPPAQVREI-DTPGTKSSPHLP-EKGQASTES--LINKNMKHF
QQCPN-TNKQRK-GQEDSRQKPKPSS--TPA---------Q-SRASVTNR-VV-RN----
LEETYAQMLLTVVGQILVKKLGLLHESA--------------PSGANSHKA---EPPGPV
GR--RA-CY--HRLPSSPDKRTTVKDMACAHNN-PSA-HSHPTKSMRVRDRDSSQ-----
------------------------VLLPQAPAR-PTSQ-----GHHRPTGR--GASG--Y
IYHRTTS------SFQRVVFSQMQQKLPHAFSSEEN-FFAEEMH----------------
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-----------------------------------------MESLPSLL-----ESIYTT
---WLSLS---STIWAMDMILAFVCGLGL-------YHLLLPFLE-SHLSSPPS------
------------------NIKFT-RKPQIQMT----------------------------
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-------------------W----------------------------------------
--------QS-QFKKKF---RN----------------------------------HCR-
NDAKAW------------------------------------G-------ECLKKLK-E-
KE--KDKLFLEEMS-----------------PGHH-LNS-L--G-----NIFNSSSAKQD
STTL-------SPFWNLKEK----------------------SE---EQVATQKLSYPKI
SE-DHFQQKCDQLFWGLPS-LHSESLVAAAW-IPQTTSTL--PSPFFLFNVISS------
----------VYPIQLQDKMSPMLPHT----HPLS---------YLDLQ-SPHLILSPL-
-EFQTP-ALN--------------------------------------------------
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----------------------------------------LP-----VLLPSSL-PYN--
----S-----DFGTSYSQS-QSKPQY-LPTEI----------------------------
--------------------KYNKKPS------LAKQIE---NRSTLPLMVQKPQEAYDI
LAPNPSQD-W-----V------VSIL--PDNFPICRELREKLEQHIQKWLIQHQ-----W
NF-PHKIQ-VSEKMKELQNTV-------------------IGNCQT-R--DKPG-----T
L-Q----------------A---LGEHSNEGQK---RKF---------------QL---E
--KES--GKNLGPILGKI--------SK-DPIR----GL-EK TTA---------------
-------------------------------I -KDLENNLKAHLGT-KSGQIDQGLTP-L
SMRQSWLAVD---DSF--YE-------MEN--NLTSLKSSA------KSMCSSEKLAFLK
PETRQALEAHIVRFWAKHRWSLP-LKILKPVKLF--------QLS-IESLPVVLCAQTSS
TTS---VHRTRSAAEV--------------------------------------------
----------------------------VRFLGKP---CLRQMI-IEDSS--P-SPQNLL
-LVSSPSCKRA----RR-----RLPFGVDHEPST-ALPTKPECGHIS--EDLTYNFMNTT
SQTR---T----------------------------------------------------
------I-----------------------------------------------------
FKKEIETR-EVV-LLPRRTSDQNLEAYKHQEKVVSEFPHNVETELAGQPQIYTTTV----
--------------LPPK-------------RSRSMPLPVDTLTSHVLG----------D
---------IV---VADMDNS--LVQ-Q-RPSTPKHLVSQ--------------------
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----------------------------KSQIK--MLAPTYQS-------EGTKRQSEIK
YEDRP-KL------------TPVTEKKANFGSQYYQTLP-KIAQVLPGR--PPQRHLGRF
LQWIH-PKKTIK-GHEFHPLKGNPTA--AIV---------QNQRRQVRKIPYM--D----
NNVTEAQELMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRE---VPPAPM
SR--FS-HG--HMPVSYLQQRRAPSYP-----GSCSC-QRCSVQNRHIRNQLPQRS--VR
FSKKPQNPR-NPSHKKPQNPRNPSRLSRNAALN-LV-N-----SQNRTIVP--GNSN--H
H--LYC--PRHCALQRD-VCR-ELGHSSVVFPNRKT------------------------
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-----------------------------------------MKKVLSILNSSILTSATES
---WLSIG---SAFMDIYPKCIILSALGL-------LFLSLRYLI-LKPFLP-T------
------------------QTSQGIRKQQGRA--KWERR----------------------
---------------------------------------------ASF----NEF--RNF
---HG--E--AR-ERRKL------------------------------------------
----QAVVQSPRGQ---LYDPS-YF--------------------RQALCQDPCCDVCDG
ATV-K------VSRL-LSWAS-LEDCS--ASASS---MASMA STASV----TE---TSFT
LSSSLSPSPSGYQLSSFSVAPSP------PPPSILSTN-TLTPLEDILL-GTPQGDS--L
PPEPTLP----STGFPLDHL-----LPHPLPKSPSMAQPAA---QQTEGPLRPED-ILSL
AGSH----------GDQFLHAT-TCDA-LP------G-----------------------
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---------S-YQQQPGA---QN---SSPS-----QLKCLVNQEIT--THNS--SEDFWR
GQASPHFTVPE-----------KVLKIH-ERQE-E------SQ-------ADLLTLK-VG
EG--EAEP----------------------------------------------TAELQN
LGAS-------FPLGGSRII----------------------LS---ELNPQ QGLAQVQP
SG-DQLETMPIQHFWGLPY-LHSESMSCITT-LSSHCSS-----MCIWFN----------
----------------RTTDSPALAPC----SPLP---------LPERQ-PQ--------
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------------------TLTQSQ----TQSIQLATPHSQLQ-----I-PPGPSPSSQ--
-SQVR-----VCGVYFRRS-Q-EAKALLQSEI----------------------------
--------------------HHIEYDM------MVKEPE---RAWALPSVVQKPQEELCL
LPSKLSLAIK-----SSKFQTPRSVP--PRDFPLTDGFQKKFEQHLRKRLILQR-----W
GL-PQGV-YKSQLWASPDPT-----------------------ESS-K--SNSR----LS
G---------------------FKHKDNKGGPN---TVSNQ-SGSPQEK---SVSI---E
-RKTV--KAQ-EQTLEII--------QK-YICS----NS-KTDLD-NGPPS-VQEVNLQ-
---------SGSLSDKPSE-----TSQVSQCR-KKFEAAPKEHLKS-HIDGTSEDQVP-V
TLSGSMHHPL----------HFKPC------------VGKE------EKKAE-----RQS
PSDI--KDEDIKSVH---------------------------------------------
---------------------------------RI----T-----VSGVQQT--------
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-----------------------------------------------------SVVLDTT
VLEE---S-E-AKRPSPDVP----KMSAKAGPMPVSKSLSSSKIVQGPQGTKMDDK---H
VFVSNKV-----------S----NIVR-EQLGGLQPRPTKISKASQCKSAED-GDGNTP-
RAQN-TQL-AGR-APEEISGPQEIQASDFSCQVTREKKSESENSQPIQASEPPR------
----------------------------------VVLPGLDKLTHTP-LPIHDQMPSSAP
ANTG-QVQ-------------------QQEPGMPAH--ALG-------------------
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----------------------------KGLNK--DS-PQSAKR------SWPA-RKIEE
LGSGV-AGPETLQPSWKSHHVQDSPTLGNHGKRPIPP-PPVKALSPPEH--QFRKHVKHF
FQWLS-PDRKCK-GQEALLKKEASPL--SPA---------HD-PE-LKGRATF-------
PGNTAAQKALRDFGKVPREQPGHRHGATDTMRPCVPESPPTKPV-KTKPKREYYVPTDPV
QGR-QL-H---PQAPVSK----VPSPRLHNQAPAFVG-QKR-----CTAERARQPQKCEA
LQP-------R------------PPASHRESELRQ-NLLWSRAGKVPQGTP-PFAVG--T
MLADMSRLCEQKILAQN--FRG------KAFVSQK-------------------------
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--------------------------------------------------MLLC------
------------------RCKEKRNALWKKG---KKKR----------------------
---------------------------------------------QTL----PGG--RAC
---QR--E--AE-QRRDL------------------------------------------
----QTAQSSSLEE---PSEAS-CN--------------------ELPLHRDPLLPVCDR
S-G-D------VGHQ-LSQDF-FKDGA--APHLC---M---ASTVPG----TE---ASFV
LPSLLTGNQAGHLAPALPPEPLP------PAPSILSPN-CFAPLEGFYS-STPLHDS--L
TPESTLP---LNPPLLPDPT-----PPYPRASFPLPT-REA---QKSEV-VFQPETTRSL
VDGL----------NEMATNFPPDQGT-GCVRQAMPE-----------------------
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---------A-SQQQPAA---DN---QLSS-----DSEN---QFLP--APHA--QVPLQ-
GDTRAYHVEPG--Y-LFFPNS-NAVKLF-QRLD-K------KV-------GDFLMVK-EE
KG--EEEEEEEEGEEEEEEEEE---EEEEEEEEEE-EGN-K--G-----CFIKSPSSLEK
LPSGETLGDSQDLVASHLSS----------------------SK---GKLPH QPLPHSKT
SE-DQEELQAAQLFWGPPF-LHSEALSPTTT-NAYDRSS-----AWVCFN----------
----------SMAEAAIADYSHGCMLP----TPLR---------AY--R-PQ--------
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--------------TWLHAAPQSQ----PQRDPPAELQPQP--QPQSRVSVLTF-SHQ--
-SELR-----DCGVHFHRP-QGDEQRLGASEM----------------------------
--------------------QCLEYNI------LKKEQE---RVWGLPLVVRKSQDTFCP
SPPKVLLGSR-----SSKACTPRPILPLPGDFPLTSELEKKLEHHLRKRLIQHR-----W
GL-PHRI-DKSLSLMSPQSEL-------------------IDFSES-K--KSRG----LS
W------------------ITLFKYQGDKDSQA---LSGGS----SRSQMPNSHSL---R
-ETGV--REW-TGSQERG--------HKDQPRG----NSLQEVSQ-SSVQS-HWRMHQKR
L--------AGRQPPEFSS-----PSQVKQYQ-KGIEKILEKHLSK-KSREISRGELP-M
TVDRSRHSVNVANIAQ--PPPETSPKRM--K-DLALLACEE------DTRTRHPHSLALS
PSKEKMLEEHITAFRRRMAFGLP-QRVEESLESY--------STKAEPSRPFLQAHIQAH
RISG-ADTAESSRSL--------RRNTTGDRMGTV----N-----SVPTQQR--------
----------------------------------------------------------PL
PAA-SLVGHSQPASENK-----------KVGVDR-DLSVAPRGREPT--QPWTPRRADKG
DLQQ---PGP-HNSPGPELP----MSPG----GPTHERLASSTNTQGSQGERRSWE---D
GSEAEGS-----------T----ELHEGEQLPGLHPQSTKSLKGTQGLCSPG-S------
-----PVT-ACQ-SPQGMSVPHNSESPDSKSQESTEVLLNSEGGTHIQVPDLSA------
----------------------------------MPSA-PQDMT------AKPQGPSGGD
MAVS-QVLHVH---LPTAGIS--MES-RQGPWVPAY--VSG-------------------
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----------------------------KSKNK--DC-LPAARG------LPQLATEAGK
LGGGD-AGLGTSQTRGKGHCVQARSPEETQGLTSSPA-LSPK-SQPQEN--QFTSQVKGF
WQRLS-PGKKHK-GQEKSLAKXCSPL--ASG---------KG-TSPIKGRYEF-------
CGNREAQNCVREPGMVLRKQLGHRHGTVT-PSPQVPVS-PLMGSEGAQQEVPLQTQVEPV
QRLPHL-C---CRATCSQ----VSRAESCSPGQGQTA-PER-----CGPTGRAKRVETSP
VHA-------S------------PPKPPL-------------------------------
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-----------------------------------------METLSSLL-----ERIYTT
---WVSLS---STMWVMDMILAFVCGLGL-------YLLLLPFLE-SHLSSPLP------
------------------NIKFT-KKPHLQMT----------------------------
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-------------------W----------------------------------------
--------QS-WCRKKF---RT----------------------------------RCR-
RDPKAW------------------------------------G-------ECLKKLK-E-
KG--KDGLFLEEIS-----------------PGHH-LNS-L--G-----NMFKSPSTKQD
STTL-------PPFWNLKEK----------------------SE---QQMAIQKLSYPKI
LG-DHFQQKYNQLFWGLPS-LHSESLVAAAW-IPQT-STL--PSPFFLFNAISS------
----------GYPVQMQARMSSVLSHT----HPLS---------YLDLQ-SPPLILSPP-
-KFQPP-TLNQ-------------------------------------------------
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----------------------------------VTLQSPLP-----ALLPSSLSSYT--
----R-----DYGTSCSQS-QRKLQC-LPTEI----------------------------
--------------------QYRERPS------VTKQLE---SRLALPLMVQRPQEVYDV
LTSNISQD-L-----A------VSIL--PDNFPISCELREKLEQHIQKWLIQHR-----W
DL-PRKIQ-ESLEVMQLQSTV-------------------IE-SQP-R--DRPG-----P
S-R----------------PFVSMGEHSMDGQK---VRF---------------KL---E
--RES--GKNLGPILGKI--------SK-HPIK----HL-EKSPV-K-------------
----------------------------------NLENGLKAHLGT-KSGQINQGLIP-LSVRRSWLAMN---NGF--T-----------T-NLASSKSSE------KSVSSLQKLAFLDPGIQQALEAHVVRFWVKHRWGLP-LKILKPINLF--------KLKSGESLPIALYAPPSS-SS---VSETSSAVEV------------------------------------------------------------------------VGFLGKPCQTCLREVI-IKDSS--P-SLGSLL-LVSSPSCKDIEK-ALG-----VFPSGVDQEPSK-TPPTKPESRHQS--ETLTHKFMDIPSQSG---T----------------------------------------------------------V-----------------------------------------------------LEKERETE-EVL-LLPRRTSVQNAGAHSHQAKVVSEFPHNVETESTGQPQVYTAAV------------------LLPE-------------RSRSVLLPADTLASQVLA----------D---------IV---VAGGGNS--LVQ-Q-QPSTPKHQVSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSQIK--VLAPTYQD-------EDTKRQNKRKHEEGS-KF------------TRVKEKEDKFRSKHYQSLP-KPTQVPPES--PFQKLVSRFLRWIH-PKKTIK-GQESSPKKGRPTA--GTA---------QSQQRQVKKKPHV--D----SNVAEAQELMSAVGEMLEKKMMLQRKLC--------------ASKFDKHRK---TPPPPVSQ--SS-YG--HKPASYSEQRRAPSHP-----VNSSC-QKCPIQDKHIRDKPSQKT--VRFSSEPQT------------PQNPNLVSPNTSMN-LVSS-----SQSGTIVP--GVSS--HH--LHCKSPV-K-----------------------------------------------NLENGLKAHLGT-KSGQINQGLIP-L
SVRRSWLAMN---NGF--T-----------T-NLASSKSSE------KSVSSLQKLAFLD
PGIQQALEAHVVRFWVKHRWGLP-LKILKPINLF--------KLKSGESLPIALYAPPSS
-SS---VSETSSAVEV--------------------------------------------
----------------------------VGFLGKPCQTCLREVI-IKDSS--P-SLGSLL
-LVSSPSCKDIEK-ALG-----VFPSGVDQEPSK-TPPTKPESRHQS--ETLTHKFMDIP
SQSG---T----------------------------------------------------
------V-----------------------------------------------------
LEKERETE-EVL-LLPRRTSVQNAGAHSHQAKVVSEFPHNVETESTGQPQVYTAAV----
--------------LLPE-------------RSRSVLLPADTLASQVLA----------D
---------IV---VAGGGNS--LVQ-Q-QPSTPKHQVSQ--------------------
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----------------------------KSQIK--VLAPTYQD-------EDTKRQNKRK
HEEGS-KF------------TRVKEKEDKFRSKHYQSLP-KPTQVPPES--PFQKLVSRF
LRWIH-PKKTIK-GQESSPKKGRPTA--GTA---------QSQQRQVKKKPHV--D----
SNVAEAQELMSAVGEMLEKKMMLQRKLC--------------ASKFDKHRK---TPPPPV
SQ--SS-YG--HKPASYSEQRRAPSHP-----VNSSC-QKCPIQDKHIRDKPSQKT--VR
FSSEPQT------------PQNPNLVSPNTSMN-LVSS-----SQSGTIVP--GVSS--H
H--LHC--PRHCVLRRS-VCS-HLENSSLVFSSRKT------------------------
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-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHWLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQGRAKRR---RKGG-------------------
----------------------------------------------TFKGF-PDW--KSF
QRE-------EE-EERKLLS-LLK------------------------------------
SFG-PPVSCSPRGQ---HHDTN-HF--------------------RRLLCPDPVCRVCKR
ATA-D------IQQL-LSWES-LKDAAP-----S---VSPLASSA SA----TE---SSFT
LASTPSATPPEDLILSPRPKASP------PPPLILSPD-LITTLADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVES-SLQPEASLSL
NTIFSFGSTLCQD------ISQAMNPIDSCARHHGPPIP-SALPP-ED----C--TVTQS
KSS-------LTILKTFP-EMLSLGGS---GGSSTS--APTIKGID-HS-HLASSE----
--------FT-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEAFLG-
GHSVANLIEPV--N-ISFLSH-DILALL-ERQV-K------KR-------GDFLMWK-EN
GK--KPGSFPKQLR-----------------PNYQ-LNS-S--R-----NMLTSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPHSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----HESPVLPPP----QPLS---------LPSTQ-PL--------
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--------------PLPQTLPQGQ----SPHLTQVKSLAQPQ-----SPFRALLPSPL--
-FLIR-----ICGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SLWGLPSVVQKSQEDFCP
PAPNPELVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRRRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--RIHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--GNYQGYSQETV--------PKDHLLH----GP-ETSSD-KDLRS-NSERDLET
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVRLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEKSHSQIKHR-NLVTLVSED------HCVDTSQEISFLS
SNKQKMLEAHIKTFRMRMLWGLP-LKVLESIEIF--------KSKADLSTSFSHFDLPSS
ATF---ISQGDSKDGVSKSRSRS--TFQGEKLGTT---------SSVPILDRPHPVSSPV
VQEGQGTLRRQFSDTDHDLIETDSKDGASTSLRRGTTDFQSEKLDSTSSF--P-ILGHSY
-LVTSPVNQEKQG-TLR-----REFSDTDNDLTE-SVRTTEDGRQTF--LPPPHSIVDEV
SQKQ---TVL-ASRCSAEL-P---IMQAGAGCESWDKRKSSFHNVDRLQGSRKT------
FPV---------------TN------------ALQSQTRNNLTTSKSGSCSL-TNVKAS-
TS---NET--E-IFPPRISVPQDPKSSYLKNQMLSQLK--LVQRKHSQPQSHFT------
----------------------------------DMSFALDNLSSKDL-LTNSQGISSGD
MGTS-QVVHVH---LEDSGIR--VAQ-KQEPRVPTCV--LQ-------------------
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----------------------------KCQVT--NFPPAVNR-------VSPVRPKGGE
LDGGD-AGLGTSQRRRKSLPVHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTS
LQWFNKPSISYE-EQESSWEKGSSLS--SCV---------QN-IGRVI-RAAF-------
TGTTEAQKIRKDTREFLEEKLGHRHGIDI-TCPQEPLSFPVGL-GKAQHNPEVHVRAEPV
QGCPCN-----YRAPSCK----VTRTKSCSQQAIFVG-QNYPTRIRQIIDKDRQPQKVEA
FKGKILCQS-HPQ-----------SMPHRKPVPHPNPTCRRQVSLVCPAVP-TSAKS--P
VFSDVPFLTGQKMLPKH--LQG------GKFPPTK-------------------------
-

-----------------------------------------MEKILSSL-----NGLTET
---WLTLG---SASYHIDLSYTLLSGLGL-------LLLYISYLI-LKLLIHLL------
------------------WRKKYTPKRQSSI--RRKKR----------------------
---------------------------------------------KAF----KRR--RVG
---QR--D--PE-EGRKL------------------------------------------
----QTVLQ-SPGK---PYDPT-VF--------------------RQLLCPDPLCRVCNK
AST-Q------VRHL-LSQAP-LGDGA--ASVSS---L---PSTA PL----TE---ASLA
LSPHFPANQPGYPAPEVPPH---------TSLSILSKD-QITPLDGVSS-PIPLSAS--L
SPQAAAS---LNPAVLLAHT-----PRRTLASFPHLHPNAT---REAQL-ALQAEVPQPP
VESP----------REWSPSVSTANST-VYEP----A-----------------------
------------------------------------------------------------
---------S-SRPPATA---EG---QSLT-----DLAHVISHQPPPSDSYA-SQGSYQ-
GLTKAYAVEPA--D-RLSPSP-DVLALF-TKQA-E------GD-------ADGTVYK-LK
KE--KAVSFLM-----------------------P-SNT-S--G-----EISASTAGLEN
LEVS-------HLLGNEQGK----------------------PE---GPHLL QQPPHLKN
CE-DQSETKDTQLFWGLPF-LHSESLKHEAA-NTGKSYP-----GRDYFN----------
----------NVAKASTGGDSSNLTYP----IPLP---------LPESD-QQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GQI--VLQSQ----IKSDSLANSKAQPQ-----PLSQFPPPSPQ--
-SQLR-----ICGVRFHSL-KNEAQTLTPCEI----------------------------
--------------------QQLEYNL------LQKALQ---SFLGLPTLTPRFQEGVCS
PPPKISSTRN-----PSKVHAPKTIQ--PGDFPLSHTLERKLEHHLRKRLIQRH-----W
GL-PHRI-LESLSFMSPHSET-------------------PEAPKP-R--DTHG----LS
W------------------ASLYKFNDNKNLPS---FGVSQ-SGGSLKKPLEIHPP---E
-DKDI--NVQ-RHCPGIS--------QRDPIQC----KS-CGATK-SSIHS-ISETDPEL
Q--------PGNMSGKFSK-----ASWVKQCQ-KECETFLQKQLGK-NTREISGSEMP-S
AVDSSRRSLN---RTQ--PPPETCPRKM------TPLPCED------DARTRHPHSLALS
PSKEKTLEEHITAFRRRMAFGLP-KRVEESLESD--------LTKAEPSYPFPQAHVQAH
DVSG-ADSAESSRSL--------RRNTTGDRMWTV----N-----PVPTQQR--------
----------------------------------------------------------PL
PAA-SLVGHSQPASENK-----------KVGVDR-DLSVVPRGREPT--QPWTPRGADKG
DLQQ---PGP-HNSSGPELP----MSPG----GPTHERLASSTNTQGSQGERRSWE---D
GSEAEGS-----------T----ELHEGEQLPGLHPQSTKSLKGTQGLCSPG-S------
-----PVT-ACQ-SPQGMSVPHNSESPDSKSQESTEVLLNSEGGTHIQVPDLSA------
----------------------------------MPSA-PQDMT------AKPQGPSGGD
MAVS-QVLHVH---LPTAGIS--MEK-S--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MESLPSLL-----ESIYTT
---WLSLS---STIWAMDMILAFVCGLGL-------YHLLLPFLE-SHLSSPPS------
------------------NIKFT-RKPQIQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-QFKKKF---RN----------------------------------HCR-
NDAKAW------------------------------------G-------ECLKKLK-E-
KE--KDKLFLEEMS-----------------PGHH-LNS-L--G-----NIFNSPSAKQD
STTL-------SPFWNLKEK----------------------SE---EQVATQKLSYPKI
SE-DHFQQKYDQLFWGLPS-LHSESLVAAAW-IPQTTSTL--PSPFFLFNVISS------
----------VYPIQLQDKMSPMPPHT----HPLS---------YLDLQ-SPHLILSPL-
-EFQTP-ALN--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LP-----VLLPSSL-PYN--
----R-----DFGTSYSQS-QSKPQY-LPTEI----------------------------
--------------------KYNKRPS------LAKQIE---NRSTLPLMVQKPQEAYDI
LAPNPSQD-W-----V------VSIL--PDNFPICRELREKLEQHIQKWLIQHQ-----W
NF-PHKIQ-VSEKMKELQNTV-------------------IGNCQT-R--DKPG-----A
S-Q----------------A---LDEHSNEGQK---RKF---------------QL---E
--KES--GKNLGPILGKI--------SK-DPIR----GL-EK TTA---------------
-------------------------------I -KDLENHLKAHLGT-KSGQIDQGLTP-L
SMRQSWLAVD---DSF--YE-------MENN-NLTSLKSSA------KSMCSSEKLAFLK
PETRQALEAHIVRFWAKHRWSLP-LKILKPVKLF--------QLS-IESLPVVLCAQTSS
TTS---VHRTRSAAEV--------------------------------------------
----------------------------VRFLGKP---CLRQMI-IEDSS--P-SPRNLL
-LVSSPSCKRA----RR-----RLPFGVDHEPST-ALPTKPQCGHIS--EDLTYNFMNTT
SQTR---T----------------------------------------------------
------I-----------------------------------------------------
FKKEIETR-DVV-LLPRRTSDQNLEAYKHQEKVVSEFPHNVETELAGQPQIYTTTV----
--------------LPPK-------------RSRSMPLPVDTLTSHVLG----------D
---------IV---VADRGNS--LVQ-Q-RPSTPQHLVSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQIK--MLAPTYQS-------EGTKRQSEIK
YEDRP-KL------------TPVTEKKANFGSQYYQTLP-KTAQVLPGS--PPQRHLGRF
LQWIH-PKKTIK-GHEFHPLKGNPTA--AIA---------QNQRRQVRKIPYM--D----
NNVAEAQELMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRE---VPPAPM
SR--FS-HG--HMPVSYFQQRRAPSYP-----GSCSC-QRCSVQNRHIRNQLPQRS--VR
FSKKPQNPR-NPSHKKPQNPRNPSRLSRNAALN-LV-N-----SQNRTIVP--ENSN--H
H--LYC--PRHCALQRD-VCR-ELGHSSVVFPNRKT------------------------
-

MGNLVIPLGKGRAGRGESGQRIPPPAPRPSVGCTGDDIALQMEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LFLLLLYVH-SDPPSPPP------
------------------GRKRSSREPQRERSGRSRSR-------KIS------------
----------------------------------------------AL----KAC--RIL
LRE-------LE-ETRDLNY-LLE------------------------------------
---------SHLRK---LAGEG-SS--------------------HLPLGGDPPGDVCKP
VPA-K------AHQPHG--KC-MQDLSP-ASL------S------PP----A--------
--------------------------PPA PLASTLSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKCP-----ATQPHVVFPPSPQPHG---PLAS---S--------
PPPP-----------------------------------------------DSRLAGLQC
GS-T-----TCPVP-----QSSPLHN----QVLPPP--TRVISGLG-CS-SDPIWD----
--------LY-CWREAAT---TW---GLST-----YSHGKSQPRYL--PDHP-SEASFW-
GDPTPKHMEVG--G-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-E-
KE--RKRADH---------------------------------------PHMTSLGKEWD
ITTL-------NPSWNVSTQ----------------------PQ---QLPRP QQVSDATT
VG-NHLQQKRSQLFWDLPS-LNSESLAATIW-VSRNPSSQ--NAHSVPLDKAST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQHFTPAWPQ
--SQPP-PLAEIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLGCSSP--
-TQIR-----GCGASYPTS-QERTQSVIPTGK----------------------------
--------------------EYLEWPL------KKR-PK---WKRVLPSLLKKSQAVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VVTSPELPEHWWQ-GRNAI-HQEQS---C
GP-PSRL-QASGDLLQPDGEF-------------------PGRPQS-Q--AEDTQQALLP
S-Q----------------PSEFAGKGRKDVQK---TGFRS-SGR---------------
--------FSEKGCLGSK---------LGPDPSRDQ-GS-GRTSV-KALD--EDK-EAEG
DLR--------RSWKYQSVSS----TPRDPDK-EHLESKLQIRLAR-KVGEIKEGWIP-M
PVRRSWLMAK---CAV--P---KSDTHRKPG-KLAS---WR---GGKAHANTSQELSFLH
PCTQQILEVHLVRFCVRHSWGTD-LQSLEPINVW---------SGEAQAPPFPQSTFTPW
ASW---VSRVESVPKV--------------------------------------------
----------------------------PIFLGKRPQNGPGDNRTTSKSV--P-TLSGSL
-AAPPPEQEGVQR-PPR-----GSQSVDTHGRSE-AFPTGHKGRGCS--QPPTCSLVGRT
WQSR---TVLESGKPKPRLKG--SMGSEMAGNEAWLESESMSPGDPCSSKA-LQE-----
-----LSIGSQWAR----AEDALQALKVGE-K--PPTWEVTLGASVRASSGS-VQEDLR-
STGALGTT-GNP-SASSVCVAQDPEQLHLK--VVSEIALIVQVDSEEQLPGRAPGILL--
----------------QDGATGPC----LPGRHMDMLTAADRLPTQ-APLSTSQSVSGKN
MTAS-QGPCAL---LWKGGDS--PGQ-Q-EPGSPKAKAPQKS--QKMLGCADKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HRRPRTGE
QGHRS-KGPRTSEASGRSHPAQAREIGDKQERKYNQLQL-EKGQTPPES--HFQRKISHH
PQGLH-PRKGGT-RWEDVLQKGKPGA--DAF---------Q-SWGSGPPR-QF-MD----
CMADKAWTISRVVGQILVDKLGLQWGRG--------------PSEVNRHKG---NFHAQE
NV--PS-CC--HRGHCHQERSREMRALACSPKATPKG-HHCPVKNRGIRDRDSSW-----
------------------------APPPREPVS-PAGP-----HHHRPRMA--STSG--G
PH--PQ--LQELRSAQRCLAS---------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
-------------------------------RGRSRSR------KKIS------------
----------------------------------------------AL----KAC--RNL
LRE-------LE-ETRDLNY-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HLPLGAEPPGDVCKP
APA-K------AHQLHG--KC-RPDPSP-ASL------S------PA----P--------
--------------------------PPA PLASTLSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPPSPQPHG---PLTS---S--------
PPPP-----------------------------------------------DSSLAGLQC
DS-T-----TRPVP-----KSSPLHS----QGLPSP--TRVISGLG-RA-SDPIQE----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDHP-LEASFW-
GDPTPRHVEVG--G-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-E-
KE--REQADH---------------------------------------LQMTSLGKEWD
ITTL-------NPFWNVSTQ----------------------PQ---QLPRP QQVSDATA
VG-DHLQQKCSQLFWDLPS-FNSESLVATAC-VSSKPSSP--NAHSVSLDKAST------
----------PLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQPFTPAWPQ
--SQPP-PLAGIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLPWSSP--
-PQIR-----DCGASYHTT-QERTQSVIPAGK----------------------------
--------------------ENLEWTL------KKG-PK---WKRVLPSLLKKSPAVLSQ
PTAYRPHERP-----ASWSPKSAPIL--PG-VATSPELPEHRWQ-GRSAI-HQEQS---C
GP-PSRF-QASGDLLQPEGEF-------------------PGRPQS-Q--AEDTQQALLP
S-Q----------------PSEFAREGRKDVQK---TGFRS-SGR---------------
--------FSGKGCLRSK---------PGPDPSQDP-GL-GRTSV-KFLE--EDKEEAEG
DIQ--------RPWKYQSVSS----TPGDPDK-KHLENKLQIHLAR-KVGEIKEGWIP-V
PVRRSWLLIK---CAV--P---QSDTHRKPG-KLAS---WR---GGKAHVNTSQELSFLQ
PCTQQMLEVHLLRFRVRHRWGPD-LQSLEPINVR---------SGEAQAPPFPQSTFPPW
AFW---ESRDKSAANV--------------------------------------------
----------------------------PIFLGKRPQNGLEDNRTTRKSV--L-TVSGAL
-APAPPEQEEAQR-PLR-----GSQSADTHGRSE-AFPTRHEDRGSS--QPPTCSLVGRT
WQSR---TVLASGKPKPRLAG--SMGSEMAGNEARFERDSMSPADVCSSRA-LQE-----
-----LSIGSQWAR----AEDALEALKVGEEK--PPAWDVTVGASVRASSGS-VQVDLR-
STGALGTT-GNP-SGSAICVAQDPEQLRLNAQVVSEIGLLVQVDSEEQPPGRASGVLL--
----------------QDGAIDLC----LPGRHVDMLPAADRLPAQ-APLSTSQSVSSKN
TTAS-QGPWAL---LRKGGDS--PRQ-R-EPGSPKAKAPQKS--QKMLGSVDKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------RRRPRPGE
QGQGS-KRPRTSEASGRSHSAHAREVGDKQERKYNQPQP-EKGETAPES--HFRRKIGHH
PQGLH-PRKAGA-GWEDVLEKGKPGA--DAV---------Q-SRGSGPAR-LF-TD----
CMVDEAWTICRGVRKILVDKLGLRWGRG--------------PSEVSCHKG---DLHAQE
NV--PS-CG--HRGHCHQEQSREMRALACSPKATPRG-HHCPVKNRNIRDRDSRW-----
------------------------APPPREPVS-PAGP-----HHHRPRVA--SASG--G
TE--VY--T-RCLAS---------------------------------------------
-

-----------------------------------------MEKVLSFL-----NSATEP
---WLSFGHFSSAFVDIHSKFIFLSAVVV-------LLLYLRYRT-LKPFLP-T------
------------------QNNQDIRQQQGKA--KKGRR----------------------
---------------------------------------------ASF----KEF--RIF
---HR--E--AQ-ERRKL------------------------------------------
----LSVVQSPFGQ---RYDAS-HF--------------------RQVLCPDPCCDVCNG
ATA-K------VRRL-LSWAT-LEDGN--ASVSS---M---AS-T SM----TE---TSFT
LTPPLSPSPPERQISSLPPAPP--------PPSTVSSN-KDTPLEDIVL-YAPQGDS--L
PSEPLLT----RTDFPRDHI-----PPPTVPPA---SQSPT---PQTEGSLPPEI-IPSM
VARL----------RERFLSATTDKEA-R-------------------------------
------------------------------------------------------------
---------------GNI---PR---FSRS-----QSRSLVNS--------H-SSDGFSG
GQTTVYFTMPG--K-PSFPSP-QVLALL-ERQG-K------SQ-------ADFLTLE-DK
EG--KAESFPK--------------------------------------------PELQS
SGGS-------LPLGGSKDR----------------------LS---DLVVH QGLAQAQI
SE-DQLEPKPTQHFWGLPY-LHSESVHTITT-LSAHCSS-----TCIWFN----------
----------------RIPDSSALTHP----TPLS---------LPGS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------QSQ----SQGVLLNTSQTQLQ-----PAIPMPPSSSQ--
-SQIT-----ICEVYFHRS-QGETKALLQSEI----------------------------
--------------------HL-----------LTKGQE---RAWSLPSVVQKSQEKFCL
LPSKPSLVRR-----SSKTHAPKSVP--SGNFPLTDAFRKKLENHLRKRLILQR-----W
GL-SERI-FKSQPWMNPDPE-----------------------ESS-M--SNHG----LS
Q------------------VSVFQHQDSKD-PH--NTVSNQ-PGSSQERCSESQSL---E
-KKME--KTQ-GQNSEAV--------QR-NLWD----NS-KGALD-NGLQS-DCQKNPQC
H--------SSSLSGKPSG-----TSQVSQYR-KKLETALQKHLTR-NLNETNKGQIS-D
TRSRSGYHPP----------PFTSQ------------VGKE------EHEAQ-----RQS
PSDK--KDGRVESKY---------------------------------------------
---------------------------------IM----A-----KSVLQQT--------
------------------------------------------------------------
-----------------------------------------------------SIILDNR
SLKE---S-E-SNKHSPDVP----RIANEAGPVSLGKRP--SKTVWGPQGTKVNDK---G
IFVSNKV-----------S----NMVKGGQFSGLQPQPTKILNTSQCKS--------TT-
KVQS-TLV-AGR-ALKETSGPQESQISDCNNPVSREEKFKSESRLPFQVLGSPN------
----------------------------------KKLPASDEFTCKP-FPIHGQSPSRGP
MDAS-PVQ-------------------RQETWMPPH--ALG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGQNK--DI-PPSAKK------LWPEPWKTEE
PGTGV-AKPRTLQANGKSFHAQDSPTQGSYGEKASQP-LPAKAQTPPEY--QFRKHFKQF
LQRLS-PDRKCK-GQEML-PRKDTSPS-SPV---------QH-PELLRGRATF-------
PGNTIAQKAMRDPGKVPKEQLGHSYGAADATRPRVPLTPPTKPV-KTKPKKEGWVPAEPV
QGS-LF-H---HQAAYPK----VPSPKSYHQATAFVG-QKR-----WVEDRDRQPQRGVV
SQP-------R------------SPTPSVGPEAHR-NSPSRRVGQVPRAVP-SLAVG--T
VLADLSRLCEQKIMAQN--FSG------KGFLPQK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------CDVCNG
ATA-N------ISHL-LSQAT-LEDGS--ASVSS---MDY--ITVSV------------T
LSFSLSENPLGNPTPDLPHEPSL------QSSSIISPH-QGTHLEDTLS-ASLLDDS--V
LSKSIPP---VNSKFSLDPD-----SLHLCTTFHLPQQHAP---QETELLLLQPVTALSL
VGSP----------RELFT-IPSNKSI-CSSRHAMSK-----------------------
------------------------------------------------------------
---------F-IQQQTDT---CD---SFRL-----EPAHLASQELL--DLHS-SGSYLQ-
RNITTCLTLPG--N-LPFPSL-DAMVLL-EKQV-G------KM-------ADSF------
-------------------------------------KT-W--G-----KTPE--SDQHN
LTVS-------HSLGSCKGK----------------------PE---RLHIHQQSHHLRT
SE-DQLEPNHIQFFWGLPS-LHSESMNSIAT-VWVDSSL-----ISGCFN----------
----------------RFSDSPVLTNH----IPLS---------LPESQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLPQILSLSQ----SQPVPPAKPQ--LQ-----HPIPVLSPFSQ--
-SQIR-----ICEGVFSQT-QDKVQPLESSEI----------------------------
--------------------HCLNYNI------LKKELE---RVWGLPTVVKKSQEEFFP
PPPKPSLVKQ-----SFKTHVLKSIS--LGNFLLTSDLRKKLENHLRKRLILQH-----W
GL-SKRI-YKSLPWVNPLAEL-------------------PETSSS-T--INYE----LS
W------------------LSFFKQQGSKDLHN---SVLNK-PGSFPARQS--------A
-EKLF--KAR-AHSTETI--------KKHQLWS----NT-KGTLD-NGLQS-NCEAILHH
H--------PGSLSGKPSG-----TSQVSQHR-ENLETALQKHLAR--------------
---QSGYHPL----------PFTSQ------------VGKE------EHEAQ-----RQS
SSDK--KDGHVESKY---------------------------------------------
---------------------------------IM----T-----KSVLQQT--------
------------------------------------------------------------
-----------------------------------------------------SIILDNR
SLKE---S-E-SNKHSPDVL------------VPLGKRLYSSKTVQGPQGTKVNVK---S
IFLSNKV-----------S----NMVKGGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MGNILSFL-----NSCTES
---GLSSG--LAYCLDIDPNFIRLTGLGL-------FMLYLFYVL-LTLYLSPA------
------------------GKNNGIPMPQGRCRRRK---KRG-------------------
-------------------------------------------------TS-KDQ--ITF
QKA-------AE-EERKLVS-FLK------------------------------------
SIG-PPAFCSPLGQ---HHNTA-RF--------------------HRLLCPDPLCVVCNR
TAA-E------IQRL-LCWES-LKDAAP-----S---VSPSTSAASE----TE---SLFT
LASASSATPPADLIVSPCPDPSP-------PPLILSPD-LITPLDDLFL-PSSLRDP--L
PPKPVPP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---QRAEP-SPHPEVSLSL
NTIFSFDSTLSQD------ISQAINPCDSCTFHYKPPNS-SASRM-QD----C--TVTQS
KAN-------LTILKALEKETLSVGGS---GGSTTS--APTIGDID-HS-CPTSAE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMQELL--SLHS-SEASLG-
ESSVVNLIAPV--K-ISFLSH-DILALL-ERQV-R------KR-------CDFLMCK-ES
GK--KPGTFPEHLR-----------------PNYQ-LNS-S--G-----KMLASIADKHG
LAAS-------LPFSASNRK----------------------VE---RLRIHQQPPYSKC
FE-DHLEQKY--------------------------------------------------
-----------------------------------------------TQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PFPQTLPQGQ----SP--------AQNP-----SPLTAQPPSPL--
-FQIG-----ICGVCFHKS-QNEAQSLTPSEI----------------------------
--------------------NHLEWNV------LQKILE---SEWGLPSVVQKSQEDFCS
PAPSLAFV-K-----SFKARGPISTI--PGDFPLSAELRKKLEHHLQKRLIQHR-----W
GL-PHRI-HESLSLLHPQSPI-------------------LEISES-E--NSEG----PL
H------------------SSLVEGQSHNDLKN---FKSRK-PRSFQKRSSNMLSL----
--ENV--GKFQGYSQENG--------PKDHLLH----EP-ETSSE-EDLSA-NSESNLEG
H--------MMHLPGNDS--------GVSLGQ-KQLANALTTHLSK-KFEEISKSQVP-G
SVRSSWHSVK---QTM--SLPEKSHSKINHR-NLTALVGED------HCVDTSQEISFLG
SNKQKMLEAHIKSFYM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYMV-LTLYLSPT------
------------------EKNNDIQKHQGRARRR---RKSV-------------------
----------------------------------------------TF----KDR--KNF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCGPLGQ---HHDTT-CF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----C---VSPLPSG ASV----TE---SSFT
LSSTPSAIPTEDLILSPRPKLSP------PPLLILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPHAK---GSF---SS-----NFVPSDFMKELL--TLHS-SEASLA-
GHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KSGSFPTQLR-----------------QNYQ-LNS-S--R-----KMLASIADKHD
MVEF-------FPFGANKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIF----HKFPVLPSP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQHQ-----SPLPVLLPSPP--
-FLIR-----ICGVCFHRP-QKEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALVRK-----SFKVHVPVSII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------HSSVEGQSLNVLKK---FGSII-PRTLHERSSNMLSL----
--ENV--GNYQGCSQENG--------PKNHLLQ----DP-ETSSD-EDPRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTAHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSED------HGVDTSQEISFLG
SNKQKMLEAHIKSFRMRMLWGLP-RKVLESIEIF--------KLKEDLSNSFSYFDLPSS
ASF---ISRGDSKDGVSKSNRQS--TFQGGKLGTT---------SSVPVLDRPHPVTSPV
GKEKSETLGKQFSDTDHDLIETDSKDRASTPLRRGTTDFQGEKLETTSSF--S-ILGHPQ
-LVTSPVDQEKHE-TLK-----REFADTDNDLTE-SVPTTEDGRQTF--LPPTHGIIDEA
SQRQ---TVP-ASRSSTEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRKT------
FPV---------------TNGSKEMFKEEESCALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQLQSHFT------
----------------------------------DMSLALDNLSSKDL-LTHPQGISSRD
METS-QVLHVH---LEDRGIC--AAQ-QQEPSVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFSPATKR-------VSPLRPKGGE
VGGGD-AGLGTSQFRRKSHVIHNKTSRELLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSITYE-DQEISRAKDSSLS--SSV---------QN-KGRVKSRAGF-------
TGSIEAQKIRKDTGEFLEEKLGHKRGIDI-TCPQEPLASPVEL-GKAQHNPEVQFTAELV
QGYPHN-----YMAPSCK----VTCTKSYSQQAVFVG-QNCPTRIRQNTDKDRQPEKVEA
FKGKILCQR-HPQ-----------SMPHRKPMPHSNPICQHQVNLVCPALP-TSANS--S
VFSDVPLLTGQKMLPKH--FQG------GKFPPTK-------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDPNFICLSGLGL-------FTLYLFYMV-LTLYSSLT------
------------------EKNNDFQKVRN-------------------------------
-----------------------------------------------------YR--KSL
QKE-------AE-EERKLHS-ILK------------------------------------
SFG-PPVSCSHLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQRL-LSWES-LKDAAP-----P---VSPLASSA SG----TE---SSFT
LASTPSATPPEDLILSPRPKPSP------PPPLILSPD-LITTSADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCAHRHEPPTP-SALPP-ED----C--TVTQS
KSS-------LTILKTFP-EMFSLGGS---GGSSTS--APTIKGID-HS-RPASSE----
--------FS-WWQPHAE---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANLIQPV--N-ISFLSH-DILALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPKQLR-----------------RNYQ-LNS-S--R-----NMLSSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVF-LQRGRSS-----MLVFFNGITN------
----------TSIS----HEPPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQPQ-----SPFPALLPSPP--
-FLIR-----VCGVCFHRP-QNEAQSLMPSEI----------------------------
--------------------NHLEWNV------LQKAQE---SVWGLPSVVQKSREDFCP
PAASPALVRK-----SFKIHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SGSSF-PRSFHERSSNMLSM----
--ENV--GNYQGYSQETA--------PKNHLLH----DP-ETSSD-EDLRS-NSERDLGT
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--CLPEKSQSQIKHQ-NLAALVSED------HCVDTSQEMSFLS
SNKQKMLEAHIKSFHMKPILNLS-I-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNTP--SSTPWVLDIFLTLVFALGF-------FFLLLPYFSYLRCDDPP-------
SPSPGK-----------RKVRS---PQSGPTEGRPRRR------MKN-------------
---------------------------------------------HSL----RAC--RER
PRG-------LE-ETWDLLS-QLQ------------------------------------
---------SLLGT---HLDKG-DF--------------------GQLSGPNPPGEVGKR
APD-G------ASRSS---LEPMEDAAP-I-------LYPLASPD PR-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------IPLFWGLPS-LHSESLVANAW-VTDRSCTL--QSPPF-FNQISN------
----------VCPIQRETTMTPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFW----PTPMAQAEAQAHLP-----SSFPVPSPTFP--
-SPIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---DRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQH--------------M
GQ-PGRI-QESLDLMQLQDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKETQK---VK---------------FQ-----
LEKDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGA-TSE-EN--
------------PLRSDSGKE----SYRKH---------------P-EIGPDQRGLDP-R
DVRRSWLAVN---QAF-----PMSNTHVKIN-NLAPPKSGK------ACVNTAQVLSFLE
QCTQQVLGAHIVRFWAKHRWGLP-LRVLKPIQCL--------KLEKISSLCSTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRKQVLTKASVHMPE----RL
-QAS----------SPA-----WISSWNDHGSLK-APTAGQEGRWPS--KPLTYSLTGST
QQNR---SL---------------------------------------------------
--------GAQSSR----ARETRE---------AEPQPRVPLATCMMENLQA-TSEDVH-
GFKAPGAS-KSS-LLPRMSVSQDPRKLCLMEEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHASENLASQVP-QRHLQSMPTGN
MQAF-QVLCDL---MAARRSN--LRH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSP--MFPPTHKS-------ENSRKPNLEK
HEEMY-QGLRTPQLTP------GRKTEDTRQNEGVQLPP-SKKQPPSIS--HFGENIKQL
FQGVF-SKKKRK-----------PAP--VTA---------E-SHKTVKNRSCV--H----
SSSAEAQELMTSVGQILEEKMSLFHARH--------------ASKVNQQRQ---QFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNRDRQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----RQHGPKIP--GASS---
-HHHHC--PRHCLLQGG-I-----------------------------------------
-

-----------------------------------------MENPLCLL-----KSVGST
---LLRMS---STSWAMDMLFAFLCGLVL-------FILLIPFLQ-TNPSFSLA------
-------------------GKKNSRKNHMEKKGQKKTS------RRSC------------
----------------------------------------------IL----KAF--REC
RRE-------LE-ETRHLVL-LLQ------------------------------------
---------RLLQK---LPGNA--------------------------------------
--E-V------NHLSHG--D----------------------------------------
-----------------------------------VP E-PQEDQ----------------
------------------------------------------------------------
-----------------------------------------------------------P
AL-RR--LPPGTGP-----QDSGLSK----SYLQSL--IRVLSGPD-LL-HHCLSF----
--------FS-WCWATAK---AT---FFSS-----WAHGKSQQEHP--SHHP-PDTVFW-
EGPSHWQAEVGRGD-HAFIHP-DVHKLL-EMLI-S------KR-------VKQKMRQ-E-
KP--KDGSFFQLVN-----------------TDYP-WIS-L--R-----NLLKSLGDKL-
-TSA-------QLFCNTKDK----------------------AE---WLLGS QQPSLHKV
LG-SPLEHECSLLFWGPPS-LHSESLVATAW-AGGRSSST--RSHCIKFNEAHT------
-----------------------------------------------HI-PGPSLQDSPL
V-------LPSVQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------PPAQLL-----CFPQKPQLTCP--
-SQVR-----ACGTTCSTS-QKKAQSFLPIEN----------------------------
--------------------QDLQWTL-------QKPLK---WRQALNSKLQKGQEPISL
PTLNLPQGSQ-----ASEAPQAVSIL--SG-DSNSAELQEKPECHRSGAFSRDEGSENLP
HP-ALRL-LPSQDLMQPLGKL-------------------PEKCQG-R--VQDSYSATQP
T-Q----------------TSAPTCGRNKTVQN---TGSQSSGR-AFYRGLVTLKL---E
--DRR--NV--QQNASED---------RKDTFR----GV-GCTPW-EVQGD----KGAQS
N--------IKGPEKYDAGSH----FSRGPDP-KDLQKDLGVHLSR-KFWQINEGMIP-V
CVRRSWLIAK---CTL--P---KSNTHTPPI-MMTCYKGKK------TCVNSTQGLSFLD
PRTPSLLEAHIKNYRLRQKCGPL-FQNLEPRNIH---------VGEAQALPPPLPSFASS
APS---DSRTDFITKL--------------------------------------------
----------------------------ATFQQEIPGKVAGLKETAQTLF--P-ILQSTI
PVARSPAWKEVQK-VSN-----GTLSDDNNGPSD-IPLSAQEVRLPS--AAS-------T
QWSS---TAFRNERGS--LVP--TPGPEMAKHDLQEGTRRMAFEGTCHGIP-VLE-----
-----IKLLSPLSV----AKESRK-PEVKE-K--HPAWEITLGTRMMENSQN-ININLR-
TLGSPYTS-NHS-SSLSRDSTHQNQAQNVKRKEHSHLDIDMLREGESCSQNVCTDSLQ--
-----------------------------D-CHTVGLLSTVIQPSQTS-VSNSQGTLYSN
TPTL-EVPCDP---SVRGVNN--QWE-Q-ESSMSRFHDAV--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSSSK--ISGSNNQS-------KNYRKPRPGN
EEQSS-AGERPFCTYELSPPAQVMEV-DSYGSMSCPHVP-EKGQIPTES--LIRKKMKHS
LQCHN-PNKECN-GQESSMQKPKPSS--ASA---------Q-TLASITNR-KV-RN----
R---------EVVGPILVDKLGLHQASV--------------PSGINLHVA---GPPEPV
GM--HS-CY--HRASSSPDKRTMVKDMACAHHDSHND-HSHPTKSMWIRDRDNNQ-----
------------------------ATP--RACA-PSSQ-----GHQRSKDI--GASG--Y
LQPHDT--------LQSAVLSHIP-QTYHAFSSETN-LFAEEMY----------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKVRNPQSR---------------------------
------------------------------------------------------------
----------PT-ELDSLLS-FYY------------------------------------
---------YLLEP---HLDKG-DF--------------------GQLSGPDPPGEVGEK
APD-G------ASQSS---HEPMEDAAP-L-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--PPPPNGFTA
PPLQ--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-WWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNQMT-----------------PEKH-LNS-L--R-----NLVKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
LQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--RSPPFLFNEMSY------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPRFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GRLALPSGVQKSQDVFSV
STPNLPQESL------------TPIL--PENFPVSPEIWRQLEQHIKKWIIQH------W
GK-LGRI-QESPDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LESDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-HLGQTNEGLIP-V
RVRRSWLAVN---QAL-----PVSNTHMKTS-NLTAPKSGK------ACVNTAQVLSFLE
PCTQQVLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLDKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPACKQFQR-APR-----GIPSWNDHGPLK-PPPAGEEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVSEFEPGMS---ETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QGHLQSMPTGN
MWAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSIS--HFGENIKQF
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
SSGAEAQGLMMAVGQMLEKKMSLCHACH--------------ASKVNQHKQ---KFQVPV
CGFPCN-----HRHLFYSEHSRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

--------------------------------------------------------MAEF
---QLNFL--SFPI----LAFV--CWVGL-------LLLSLCYLK-GNSSFSIF------
------------------WKQGDIDQRQGRTRRRRKGG--T-------------------
--------------------------------------------LKG-------W--RTC
---QS--E--AE-EARTELY-LLQ------------------------------------
---------SPLGQ---HDDTT-CF--------------------RQLLCPDPFCEVCNN
ATA-E------VNRL-LFLEA-LEDAT-----SS---VSPLASTA PV----TE---SSFT
LSPAFSAVPPGNLPPASLPEPSS------LPSSVLSPS-PMTPLTDFFS-PSPMGHS--L
ASGAFSS---LDSEFPVDYS-----PPQTVAFPLLLP-HDT---QTADP-VVPAEATLFL
DTMSSLDPTLSQEINPLSDFSQAMNPTDSFACPHAPPTP-FVSPL-PD----GTLSVTQP
KSI-------STLLKPVL-EKSSPDSP---SELSTC--VSTIRGTE-PS-SLSISD----
--------FS-LWQAQAM---NV---LLPG-----LPHSDFQRERV--SLHP-QGTYLW-
GDSVTKHKEAN--S-HSFSGF-HIHGLL-ERQI-K------NR-------MACRSLE-KK
EK--EEGPFSKQ------------K-----WSEYQ-WTS-S--G-----HLLQSL-GVQN
TTAP-------QTGWNSESK----------------------PE---KLHIC QQLLYVKT
LG-GNLQQKYSQLFWGLPS-LHSESLVATLL-VSSSSSPP--ESHFVLFNGICN------
----------APAAKMRDQESPPLLHS----RPRL---------LPHVYPPQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------CLPQTKPQSQ----SLPFTQVQAQAHLQ-----ARLPMLSSSSP--
-SQIR-----DCGVSFHRF-QNESDFHIATEN----------------------------
--------------------QHLEWHV------LQKQQE---SLWGLVPVLQKSQ-VTCS
QAHNVPLVNQ-----PSHAYVPVSIL--PGHFHITSEPQEKLELHVPRRLNPRW-----Y
LQ-ACRN-LESLALMGPQCKL-------------------AEVPQQ-R--GRHV----QL
Q------------------HSKLQGQGSNNIEK---TELGL-PGNFQEKVSTKFQL---R
--DDM--RKNLGYILEKS--------PEDSPQD----VS-ECYLV-QGLRA-AL--ETKT
N--------CVFQSRNHSRNELLNVSRKDIDR-NQIKNILRLHVSM-KSWQISVGRIP-T
GVCRSWLADD---NTL--LPSASSRTNVEDPHSKNITGGKV------CHQISTPELSFLD
HNTLKVLEAHILRFRVTQRWGLP-LKVLESIKFY--------MLREAKTWPLPQFDFPSS
TTH---ISGVDSKDELS-------------------------------------------
-----------------------------EPLEERSKTSQGNKVRTTNST--P-MLDHPL
PVI-SSVGQEGQR-APQ-----PSYSDTYQKLAE-DIQTIECRRQTF--QPITHGNKGKV
SQNE---ILL-ENRCSPVMP----IRQAGYRPEPRDETVNFSDRVEMVQGQKIARKNSEH
STMFSVS-----------R----EIFRAKELHALESQSCNILTKSKLRSSQM-TKAKMT-
KVETTLTT-QCP-P-PKLSVPQDSEISDFQKQILTELKFKFKNKEHSQADHCPT------
----------------------------------DTSPTSSRLPSKS-LQTPAQSVSTGD
MAAS-QVPHIH---SEDSGTS--MEQ-RRNPS--KH--ALL-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQDN--NF-PPAAER-------EPLGSKAGE
YRSED-SGTGMSTGRKKSHLVEER-ELK----DASSS-VSQSEQLPPES--FFRNKMRRF
FQWID-FMRKIK-DQESAQQKAKFMS--TFA---------QH-QDSTESAAFF-VSHGPL
E----AHELMRAIGKILEEKLACRFESE--------------ALQLSQHKKELQTQVKPG
KGH-PS-N---YGALPDLRQEEWVSPKSSNQEAVYAD-QSCLTSIRQNRDGVRHPSKDVA
FEDQVLCQS-QP-----------SSLSSRELASHPSPTCVHQECQIPPAPL-TPEED--T
VFRDLTLLFKQKSLLQH--FQG------EEISPKNS-FRH--------------------
-

-----------------------------------------MENILCFL-----NSYTES
---GLSPG--LAHCLDIDPNFICLSGLGL-------FMLYLFYVL-LTLYLSPP------
------------------RKNNDIQMRQGRARRRK---KVR-------------------
-------------------------------------------------TF-KGK--ITF
QKE-------AE-EERKLVS-FLK------------------------------------
SFR-PPASCSPLGQ---QHDTT-RF--------------------RRLLCPDPLCMVCNR
TTA-E------VQRL-LCWES-LKEPAP-----S---VSSLASAA SA----TE---SSFT
LASAASATPPEDLIVSPCPDPSP------PPPLILSPD-LITPLADLFS-PLPLRDP--L
PPKPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---QRAEP-NLQPEASLSL
NTIFLFDSTLSQDMNSLPNISHAMNPCDSCTFHYKPPNS-FALRM-QD----C--TVSQS
KAS-------LIILKPLEKETLSVGGS---GGSTTA--APTIGDID-HS-CPASAE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMQELL--SLHS-SETSLG-
GYAVVNLIVPV--K-LSFVSH-DIVALL-ERQV-K------KR-------GDFLMCK-EN
GK--KPGTFPKHLR-----------------PNYQ-LNS-S--G-----KMLASTSDKHG
LTTS-------LPFSASNRK----------------------VE---GLYIH QQPPYSKC
FE-DHLEQKYVRLFWGLPS-LHSESLNPTVL-LHRGRSS-----MFVFFNEIAS------
----------MSAF----QEPPVLPHP----QPLS---------LPITQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SL--------AQHP-----SLPTAQLPSPL--
-FQIG-----ICGVCFHKS-QNEGQSLTPSEI----------------------------
--------------------NHLEWNV------LQKDQE---SVWGLPSVVKKSQEDFCS
PVPSLTLV-K-----SFKACDPIPIS--TGDFPLSTELRKKLEQHLRKRLIQHR-----W
GL-PRRI-HESLSLLRPQSPI-------------------LEISES-E--NSEG----PL
H------------------SSLVEGQSHNDLKN---FKSRK-PRGFHKRSSNMLSL----
--ENV--GKLQGYSQENG--------PKGDLLH----EP-ETSSE-EDLSS-NSESDLEG
H--------MMHLPGNDL--------GVSLGQ-KQLANALTVHLSK-KFEEINEGRVP-G
NVCSSWHSVK---QTM--PLPEKSHSQLNHR-NLAALVGED------HCVDTSQEMSFLG
SNKQKMLEAHIKYFHMRMLWGLP-SKVLESIEIC--------KSKEDLSSSFSNFDLPSS
ATF---ISQRDSKDGACKSLRCS--TFQGEKLGTS---------SVLV-LDRHDPVASSV
GKERQGTLRRQFSYTENDLTEMDSNDGDSKLLGRNTTDFHAEKIETTSLF--S-ILNHPH
-LITLPDDKERHG-TLR-----REFSDPDHELTE-SIQTTNDGRQSF--LPCTHSIIDEV
SQKQ---TGL-ASSSYPEL-P---IMQPEVGSESMDKKVSFSNNMERLQGSRKT------
FPV---------------TSGSK-----------EM------------------------
-----------------------FKEEKLKHQMLSELK--LAHGEHSPAQTHFA------
----------------------------------DMPLALDNLTSKGL-LTNVQGISNGN
MAIS-QVLNVH---VEDRGIR--VEQ-QQEPLVPKHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------NCQVK--NFPAATKR-------VSPPRPKGRE
LGGGN-VGLGNSQPRRKSYPVQKKTSGEVLGRKSSPTL---ITQPPPEN--LFRKWLKNF
FQRFKKLSITCE-EQESFQAKGSSLS--SSV---------QN-RGRVKSRAAF-------
TGTAEAQKIKTDIVKFLKEKLGHRDGIDI-TCPQEPLSSPVEL-GKAQHDPELQVRAEPV
QGYPCS-----YTAPSCK----VTCSESCSQQAILVG-QNHPTKIRQIIDKNRQPQEVEA
FKGKILYQR-HPQ-----------SMPHRKPVPQPNPTCQCQVDPVPPAVP-TTAKS--T
VFSDLSLLITRKILLKH--FHG------GKFPPTK-------------------------
-

-----------------------------------------MENLPSLL-----ESIYTT
---WLSLS---STIWAMDMILAFVCGLGL-------YHLLLPFLE-SHLSSPPS------
------------------NIKFT-RKPQIQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-QFKKKF---RS----------------------------------HCR-
NDAKAW------------------------------------G-------ECLKKLK-E-
KE--KDKLFLEEMS-----------------PGHH-LNS-L--G-----NIFNSPSAKQD
STTL-------SPFWNLKEK----------------------SE---EQMATQKLSYPKL
SE-DHFQQKYDQLFWGLPS-LHSESLVAAAW-IPQTTSTL--PSPFFLFNVISS------
----------VYPIQLQDKMSPMLPHT----HPLS---------YLDLQ-SPPLILSPL-
-EFQTP-ALN--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LP-----VLVPSSL-SYN--
----R-----DFGTSYSQS-QSKPQY-FSTEI----------------------------
--------------------KYNERPS------LAKQIE---NRSTLPLMVQKPQEAYDI
LASNPSQD-W-----V------VSIL--PGNFPISCELREKLEQHIQKWLIQHQ-----W
NF-PHKIQ-VSEKMKELQNTV-------------------IGNCQT-R--DKPG-----T
S-Q----------------A---LGEHSNEGQK---RKF---------------QL---E
--KES--GKNLGPILGKI--------SK-DPIR----GL-EKTTA---------------
-------------------------------N-KDLENNLKAHLGT-KSRQIDQGLTP-LSMRQSWLAVD---DSF--YE-------MENN-NLTSLKSSA------KSMCSSEKLAFLKPETRQALETHIVRFWAKHRWGLP-LKVLKPVKLF--------QLS-IESLPVVLCAQTSSTTS---VHRTRSAAEV------------------------------------------------------------------------VRFLGKP---CLRQMI-LEDSS--P-SPRNLL-LVSSPSCKRA----MR-----RLPFGVDHEPST-ARPTKPECGHVS--EGLTYNFMDTTSQSR---T----------------------------------------------------------F-----------------------------------------------------FKKEIETR-EVV-LLPRRTSDQNLEAYKHQEKVVSEFPHNVETELAGQPQIYTTTV------------------LPPK-------------RSRSMPLPVDTLTSRVLG----------D---------IV---VADRGNS--LVQ-Q-RPSTPKHLVSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSQIK--MLSPTYQS-------EGTKRQSEIKYEDRP-KF------------TPVTEKKANFGSQYYQTLP-KTAQVLPGR--LPQRHLGRFLQWIH-PKKTIK-GHEFHPLKGNPTA--AIA---------QNQQRQVRKIPYM--D----NNVAEAQELMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRE---VPPAPTSR--FS-HG--HMPVSCLQQKRAPSYP-----GSCSC-QRCSVQNRHIRNQLPQRS--VRFSKKPQNPR-NPSHKKPQNPRNPSHLSRNTALN-LV-N-----SQNRTIVP--GNSN--HH--LYC--PKTTA----------------------------------------------N-KDLENNLKAHLGT-KSRQIDQGLTP-L
SMRQSWLAVD---DSF--YE-------MENN-NLTSLKSSA------KSMCSSEKLAFLK
PETRQALETHIVRFWAKHRWGLP-LKVLKPVKLF--------QLS-IESLPVVLCAQTSS
TTS---VHRTRSAAEV--------------------------------------------
----------------------------VRFLGKP---CLRQMI-LEDSS--P-SPRNLL
-LVSSPSCKRA----MR-----RLPFGVDHEPST-ARPTKPECGHVS--EGLTYNFMDTT
SQSR---T----------------------------------------------------
------F-----------------------------------------------------
FKKEIETR-EVV-LLPRRTSDQNLEAYKHQEKVVSEFPHNVETELAGQPQIYTTTV----
--------------LPPK-------------RSRSMPLPVDTLTSRVLG----------D
---------IV---VADRGNS--LVQ-Q-RPSTPKHLVSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQIK--MLSPTYQS-------EGTKRQSEIK
YEDRP-KF------------TPVTEKKANFGSQYYQTLP-KTAQVLPGR--LPQRHLGRF
LQWIH-PKKTIK-GHEFHPLKGNPTA--AIA---------QNQQRQVRKIPYM--D----
NNVAEAQELMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRE---VPPAPT
SR--FS-HG--HMPVSCLQQKRAPSYP-----GSCSC-QRCSVQNRHIRNQLPQRS--VR
FSKKPQNPR-NPSHKKPQNPRNPSHLSRNTALN-LV-N-----SQNRTIVP--GNSN--H
H--LYC--PRHCALQRD-VHR-ELGHSSVVFPNRKT------------------------
-

-----------------------------------------MENILSFL-----NR---S
---WLGFG---SAFLDIGSNYIFLSGVWS-------ILLYLWYLI-LKPFFPPP------
------------------WKSQDIKKYQGSA--NKGRR----------------------
---------------------------------------------KSL----KGC--RMT
---QR--K--TQ-EQRKL------------------------------------------
----LSIAQSPLGE---EYDAS-NF--------------------RQLLCPDPFCGVCNG
ATA-K------ISHL-LSQAT-HQDGA--VTMSS---MDS---T VSM----TE---TSLT
LSLPLPENTIEYPISDTTYEPSL------QSSSIISSH-QNEYLEDTFS-LSPLGGS--L
LSESIPP---VNAKSPLDHN-----SLHPLASLPLPQQYAT---QETEL-LLQPTTVLSL
VDSP----------MELFTNVPINNGI-CSSSHAVSE-----------------------
------------------------------------------------------------
---------F-IQQQTDT---GN---SSQL-----ESAHPVNQELL--DPYS-SESYLW-
GNTSTYLTLPG--N-LHFSSL-GAVALL-ETQD-G------RR-------ADSL------
-------------------------------------ET-W--E-----KTSE--FDHQN
LAVS-------HSLGSSK-------------------------E---RLHTP QHLSYSKT
SE-DQLEDKHTQSFWGLPS-LHSESMNSIAT-VLTDSSP-----ISGCFN----------
----------------RFSDSPMLTHR----TTLP---------LSESQ-LH--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLSQSLSQSQ----SQPVPQANLQAQLQ-----PPNPVLSP-P---
-SQLR-----ICGVYFHSP-QNEAEPLEPSAI----------------------------
--------------------HCLEYNI------LKKEQE---RVWGLPTVVKNSQQEFCP
PPPNPSLVSQ-----LSKTHVPKSIS--IENCLITSELQKKFEHHLRKRLILQH-----W
GL-PKRI-RESLLWINPQAEF-------------------PESHSS-K--SNYG----LS
W------------------IPFFKQQRKKDLRN---TILNQ-PGSFPAKQL--------E
-EKLL--KLCSKQGLEMV--------QKQQTWS----NT-KSTLD-SGLQS-DCETNLQC
H--------SDSLSCKPLG-----TSEVSQCQ-KKLETSLKEHLTT-RLNETIEGQIT-S
TMSRSRYGPF----------TFTSC------------VNKK------EHKAQ-------K
PSDI--KDGHVKNIS---------------------------------------------
---------------------------------PA----K-----KSVKQQT--------
------------------------------------------------------------
-----------------------------------------------------SFDLDNT
SLED---S-K-GNRHSSDVP----KMLAEV----LDKRLTSGKTVQRPQATKIIDK---N
VFIPNKV-----------G-------KGGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MEKVLSFL-----NSATEP
---WLSFGHFSSAFVDIHSKFIFLSAVVV-------LLLYLRYRT-LKPFLP-T------
------------------QNNQDIRQQQGKA--KKGRR----------------------
---------------------------------------------ASF----KEF--RIF
---HR--E--AQ-ERRKL------------------------------------------
----LSVVQSPFGQ---RYDAS-HF--------------------RQVLCPDPCCDVCNG
ATA-K------VRRL-LSWAT-LEDGN--ASVSS---M---AS-T SM----TE---TSFT
LTPPLSPSPPERQISSLPPAPP--------PPSTVSSN-KDTPLEDIVL-YAPQGDS--L
PSEPLLT----RTDFPRDHI-----PPPTVPPA---SQSPT---PQTEGSLPPEI-IPSM
VARL----------RERFLSATTDKEA-R-------------------------------
------------------------------------------------------------
---------------GNI---PR---FSRS-----QSRSLVNS--------H-SSDGFSG
GQTTVYFTMPG--K-PSFPSP-QVLALL-ERQG-K------SQ-------ADFLTLE-DK
EG--KAESFPK--------------------------------------------PELQS
SGGS-------LPLGGSKDR----------------------LS---DLVVH QGLAQAQI
SE-DQLEPKPTQHFWGLPY-LHSESVHTITT-LSAHCSS-----TCIWFN----------
----------------RIPDSSALTHP----TPLS---------LPGS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------QSQ----SQGVLLNTSQTQLQ-----PAIPMPPSSSQ--
-SQIT-----ICEVYFHRS-QGETKALLQSEI----------------------------
--------------------HL-----------LTKGQE---RAWSLPSVVQKSQEKFCL
LPSKPSLVRR-----SSKTHAPKSVP--SGNFPLTDAFRKKLENHLRKRLILQR-----W
GL-SERI-FKSQPWMNPDPE-----------------------ESS-M--SNHG----LS
Q------------------VSVFQHQDSKD-PH--NTVSNQ-PGSSQERCSESQSL---E
-KKME--KTQ-GQNSEAV--------QR-NLWD----NS-KGALD-NGLQS-DCQKNPQC
H--------SSSLSGKPSG-----TSQVSQYR-KKLETALQKHLTR-NLNETNKGQIS-D
TRSRSGYHPP----------PFTSQ------------VGKE------EHEAQ-----RQS
PSDK--KDGRVESKY---------------------------------------------
---------------------------------IM----A-----KSVLQQT--------
------------------------------------------------------------
-----------------------------------------------------SIILDNR
SLKE---S-E-SNKHSPDVP----RIANEAGPVSLGKRP--SKTVWGPQGTKVNDK---G
IFVSNKV-----------S----NMVKGGQFSGLQPQPTKILNTSQCKS--------TT-
KVQS-TLV-AGR-ALKETSGPQESQISDCNNPVSREEKFKSESRLPFQVLGSPN------
----------------------------------KKLPASDEFTCKP-FPIHGQSPSRGP
MDAS-PVQ-------------------RQETWMPPH--ALG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGQNK--DI-PPSAKK------LWPEPWKTEE
PGTGV-AKPRTLQANGKSFHAQDSPTQGSYGEKASQP-LPAKAQTPPEY--QFRKHFKQF
LQRLS-PDRKCK-GQEML-PRKDTSPS-SPV---------QH-PELLRGRATF-------
PGNTIAQKAMRDPGKVPKEQLGHSYGAADATRPRVPLTPPTKPV-KTKPKKEGWVPAEPV
QGS-LF-H---HQAAYPK----VPSPKSYHQATAFVG-QKR-----WVEDRDRQPQRGVV
SQP-------R------------SPTPSVGPEAHR-NSPSRRVGQVPRAVP-SLAVG--T
VLADLSRLCEQKIMAQN--FSG------KGFLPQK-------------------------
-

---------------------------------------FSKLECSPFL-----NRDTEP
---CLSSV---STCLETDPNFTCLF-YGV-------LLLLLFYLL-GIPFL--R------
------------------WRTKSIHKGQGRAKRR---RKGG-------------------
----------------------------------------------PLKGF-PDY--RCY
QGE-------VE-KTRKLLS-VLS------------------------------------
SFV-PPASCSPLGR---HHDTI-YF--------------------RQLLCPD-PCEVCNG
KTA-E------INRL-LFPEA-LEDAT------------PLASTAPV----TD---SSST
LSPAFSAVPPGDLISASLSEPSP------PPASNFSPN-PVAPLTDLFP-PSPPGDS--L
PPEHFPP---LHSKFPMDHF-----SPQPLAFP-PVPPHDA---QTVDS-LVQPEANLSL
NTIFN----------PLPEHSQTTNPTDSSACPQASPTL-SVSP--PD----RSITATQS
KSF-------SITVKPVP-ESSSADSP---GGLSTY--VTTNTGID-HS-SLSISD----
--------SP-RWQTHAR---DFF---PS-----TLAPCHFPQEFL--ALHS-SEASSR-
GDPAANFTEPG--N-LSLLSP-DILALL-EKQV-Q------KK-------SDLLMWK-DM
KG---GSSLPKNLK-----------------PDYP-PNS-L--G-----KMLGSIAYKPD
LSDL-------LPIWSSKDQ----------------------SK---EMPVH QQPPYSTN
LEEGHLQQTSIQLFWGLPT-LHSESLSSAAR-DSDDCSS-----IFI-FSRISN------
----------TSTG----QESPVVPHP----SPLP---------LPENQ-S---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------QPIPQIQPQIHLK-----SPLPILPSGPL--
-PQIK-----ICGVCFHRP-QHKSEPLLSSEM----------------------------
--------------------QRLEWNV------LQKQQE---SVWGLPPVVQRSNKDFCP
SAPDRSIKRP-----AFQARVAISIL--PGQFPLSEELRKELEHHLRKRLIQHR-----W
GL-PRRI-YESVSLMMPPSDS-------------------SETPKC-Q--RFRG----RT
W------------------ISKSHSNLS------------E-SESY----EQDSELLQ-L
RNIDM--GKDQGHNPGSG--------PKDHLLS----Q---NSSD-NDLGY-DSEKEFRS
------------PSEKNP------MSLDTAGQ-RQLENVLKIHLSK-KFEEINEGRLP-G
TVHNSWHTMK---QML--LLSKKSHTEIKQR-SLPPSVGED------YTLNTFQELSFVE
SSAQEMLEAHIRRFCMRMIWGLP-PRVLESIQLF--------KLREAST----HSSFCSS
TNL---ISEVNSK------------SLLGDKAAIA---------NSGPILDRPLP-----
------------------------------------------------------------
--ATSTMGEGEQR-IPR-----GSPSHINHELAE-DVQRIKEGRQTF--LPIRHDTTGRA
SQRQ---TLP-ANRWPPTQ-T---AREAGAGHEPKDKRAYSSGRVEMQQVSREIF-----
--------------------------RAKELDARQ-SR----SNDTLT-TSK-LHVNQN-
KIRSTVPI--Q-SPSQNISILQDPKSSKLKEQLLSELKLKLENREYSRVHGQCT------
----------------------------------GLPAASNSLTYKVS-LTHAHSIISGG
IGAS-QVLRVH---PEDTKVS--MEQ-QQDPWVSKHV--LR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------EHQNK--NPPPAAVT-------VSPLGSKAEE
LGGWD-AEFGTSQLRKKSFPREDVALKKSFP------TQ-DKGQPRPES--LFREKMNPF
LQWLN-PGIKCK-RQ-NSQVKGTPQ---SSV---------ES-RGLVKGRTAF-------
TGMTKDQKIMTDGGKVLEEEMGCRHAIDI-TCPQQPLPSPTKL-GKTQPKAQVQAQAQSV
QGHPFN-----HRTPSCK----ETDTKSCHQEAVFGG-QGHFRSIGQIREKERCPHKAVA
FKDQLLCQK-YPL-----------SMPHREPVSHPTPTSRHPGGQGPPANL-LAAKS--S
VFRGLSLLFRHKTFLQN--LQG------GKTSHPQ-------------------------
-

-----------------------------------------MENLPPLL-----ESIYTT
---WLNLS---STIWAMDMILALVCGLGL-------YLLLLPFLE-SHLSSPPS------
------------------NIKLT-RKPQIQMA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-QFKKKF---RN----------------------------------HFR-
NDAKAW------------------------------------G-------ECLKKLK-E-
KE--KDELFLEKMS-----------------PGHH-LNS-L--G-----NIFNSPSAKQD
NTTL-------SPFWNLKEK----------------------SE---EQMATQKLSYPKI
SE-DHFQQKYDQLFWGLPS-LHSESLVAAAW-IPQTTSTL--PSPFFLFNVISR------
----------VYPIQLQDKMSPMFPHT----HPLS---------YLDLQ-SSPLILSPL-
-EFQTP-ALNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VHFQSHFP-----VLLPSSL-PYN--
----R-----DFGTSYSQS-QSKPQY-LPTEI----------------------------
--------------------KYNERPS------LAKQIE---NRLTLPLMVQKPQEAYDI
---NPSQD-W-----V------VSIL--PDNFPISCELREKLEQHIQKWLIQHQ-----W
NF-PHKIQ-DSEKMKELHNTV-------------------IGNCQI-R--DKPG-----T
S-Q----------------A---LGEHSNEGQK---IKF---------------QL---E
--KES--GKNLGPILGKI--------SK-EPIR----GL-ENTIV---------------
-------------------------------N-KDLENNLNAHLGT-KSGQINQGLTP-LSMRQSWLAMD---DGF--YE-------METK-NLTSLKSSA------KSMCSSEKLAFLKPETRQALEAHIVRFWAKHRWGLP-LKILKPVNLF--------KLS-TESLPVALCAQTSSTTS---VHRTSSAAEV------------------------------------------------------------------------VRVLGKP---CLRQMI-IEDSS--P-SPGNLL-LVSSPSCKRA----IR-----RLPFGVDHEPST-ALPTNPERGRIS--ETLTYNFMDTTSQSR---T----------------------------------------------------------I-----------------------------------------------------FKKAIETQ-EVL-LLPRRTSDQNSEAYKLQEKVVSEFPHNVETELAGQPQICTTTV------------------LPPK-------------RSRSMPLPVDTLTSHVLG----------D---------TV---VADRGNS--LVQ-Q-RPSTPKHLVSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSQIK--MLAPTYQS-------EGTKRQSEIKYQDRP-QF------------TPVNEKKVNFGSQYYQTLP-KTAQMLPER--PPQRRLGQFLHWIH-PKKTIQ-GQEFHPLKGNPTA--ATA---------QNQRRQVRKKPYM--D----NNVAEAQEFMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRQ---VPPGPTSQ--FS-HG--HMPVSYLQQRRAPSYP-----GNCSC-QRCSIQNRHIRNQLPQKS--VHFSKKPQI------------PRNPSHLSRNAALN-LV-N-----SQNRTIVP--RISN--HR--LYC--PRHCVLQRN-VCR-ELGHSSVVFPNRKT-------------------------N-KDLENNLNAHLGT-KSGQINQGLTP-L
SMRQSWLAMD---DGF--YE-------METK-NLTSLKSSA------KSMCSSEKLAFLK
PETRQALEAHIVRFWAKHRWGLP-LKILKPVNLF--------KLS-TESLPVALCAQTSS
TTS---VHRTSSAAEV--------------------------------------------
----------------------------VRVLGKP---CLRQMI-IEDSS--P-SPGNLL
-LVSSPSCKRA----IR-----RLPFGVDHEPST-ALPTNPERGRIS--ETLTYNFMDTT
SQSR---T----------------------------------------------------
------I-----------------------------------------------------
FKKAIETQ-EVL-LLPRRTSDQNSEAYKLQEKVVSEFPHNVETELAGQPQICTTTV----
--------------LPPK-------------RSRSMPLPVDTLTSHVLG----------D
---------TV---VADRGNS--LVQ-Q-RPSTPKHLVSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQIK--MLAPTYQS-------EGTKRQSEIK
YQDRP-QF------------TPVNEKKVNFGSQYYQTLP-KTAQMLPER--PPQRRLGQF
LHWIH-PKKTIQ-GQEFHPLKGNPTA--ATA---------QNQRRQVRKKPYM--D----
NNVAEAQEFMTTVGQMLEKKMMLQHQPY--------------ASKFNQHRQ---VPPGPT
SQ--FS-HG--HMPVSYLQQRRAPSYP-----GNCSC-QRCSIQNRHIRNQLPQKS--VH
FSKKPQI------------PRNPSHLSRNAALN-LV-N-----SQNRTIVP--RISN--H
R--LYC--PRHCVLQRN-VCR-ELGHSSVVFPNRKT------------------------
-

-----------------------------------------MIY----------------
------------LPWPPKLL-----GLQF-------FINKLFISIFMSNQDKKNSSPFLV
SQCHLVSQRHLVSPCHLVSPRHRVSQCPVGWWGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--REC
LRG-------LE-ETWDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGKR
ASD-G------VSRSS---HEPVEDA----------------------------------
--------------------------HPQDLAS TTSPG-PMTTSV------SSPSAS--Q
PPEPS---------LLLECP-----SPKPPALFPHPPHTPD---PLACS--PPPPKGFTP
LPLW--D--------------------------------------------STLITPSHC
DS-VA--LPLGTIP-----QSLSPCE-----DLVAS--VPAISGLG-SS-NSQVSA----
--------FS-WWQETTR---SWS-----------VFNSS VQQDHL--SR----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QRETTMSPLRFL------------------------SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFQ----PTPMAQA----DLQ-----SSFPVLSPAFP--
-SPIK-----NTEVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSSIQKSQDVFS-
-------ERL------------TSIL--PENFPVSPELRRQLEQH--------------M
GQ-PGKI-QESLDLMQLRDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LERDR--CPHLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
ILR--------KPLRSDSGSD----LLRCTER-NRIENLLKAHIGR-RLSQTNEGLVP-L
TVRRSWLAAN---QAF-----PVPNTHVKTS-NLAAPESGK------ACVNTAQVLSFLE
PCAQQVLGAHIVRLRAKHRWGLP-LTVLKPIRCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATSLRKPPMASLRKQVLTKASVHMPE----SL
-LASSPACEQFPM-VPR-----GMPSWNGHGPLK-APSAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRQ---------AVPQPRVPLGTCRLANLQA-TSEDVR-
GFEAPGTS-KSS-LLPTVSVSQDPRKLCLREEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHPSENLASQVP-QGHLQSMPTGN
MGAS-LELRDF---TAARRSN--LGH-K-EI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ESQSA--MFPSTHKR-------KNSRNPNLEK
HEEMF-QGLRTPQLIP------CRKTEDTHQDAGIQLLP-SKKQPPS-------------
--------KKRK-----------PAP--VTA---------E-SQKTVKIRPCM--Y----
SSSAEAQRLMAAVGQILEEKMSLCHAHH--------------ALKVNQHQQ---QFQAPV
CGFPCN-----HRRPFYSEHSRMLSYAASSQPATLKT-QSCPNRDRQIRDQQ--PLKSVR
CNNKQWGLR-HPQ-----------LLISKKAVS-P--------------IP--GASS---
-HHHHC--PRHCLLQGG-I-----------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MSRP-LCEVCNG
KTA-E------INRL-LFPGA-LEDAT------------FLASTAPV----TD---SSFT
LSPAFSAVPPGDLISASLSEPSP------PPASIFSPN-PVTPLTDLFP-PSPPGDS--L
PPEHFPP---LHSKFPMDHF-----SPQPLAFP-PVPPHDA---QTVDS-LVQPEANLSL
NTIFN----------PLPEHSQTTNPTDSSACPQASPTL-SVSP--PD----RSITATQS
KSF-------SITVKPVP-ESSSADSP---GGLSTY--VTTNTGID-HS-SLSISD----
--------SP-RWQTHAR---DFF---PS-----TLAPCHFPQEFL--ALHS-SEASSR-
GDPAANFIEPG--N-LSLLSP-DVLALL-EKQV-Q------KK-------SDLLMWK-DM
KG---GSSLPKNLK-----------------PDYP-PNS-L--G-----KMLGSIAYKPD
LSDL-------LPIWSSKDQ----------------------SK---EMPVHR QPPYPTT
LEEGHLQQTPIQLFWGLPT-LHSESLSSAAC-DSDDCSS-----ILI-FSRISN------
----------TSTG----QESPVVPHP----FPLP---------LPENQ-S---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------QPIPQIQPQTHLK-----SPLPLLPSGPL--
-PQIK-----ICGVCFHRP-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILSFL-----NR---S
---WLGFG---SAFLDIVSNYIFLSGVWS-------ILLFLWYLI-LKPFFPPP------
------------------WKSQDIKKHQGSA--NKERR----------------------
---------------------------------------------KSL----KGC--RIT
---QR--K--SQ-EQRKL------------------------------------------
----LSVVQSPLGE---EYDSS-NF--------------------RQLLCPDPYCGVCNG
ATA-K------ISHL-LSQAT-HQDGA--VTMSS---MDS---T VSV----TE---TSLT
LSLPLPENTIEYPISDTTYEPSL------QSSSIISSH-QSEYLEDTLS-LSPLGGS--L
LSESIPP---VNAKSPLDH------SLHSLASLPLPQQYAT---PETEL-RLQPTTVLSL
VDSP----------MELFANVPINNGI-CSSSHAMSE-----------------------
------------------------------------------------------------
---------F-IQQHTDT---GN---SSQL-----ESAHPVNQELL--DPYS-SESYLW-
GNTSTYLTLPG--N-LHFSSL-GAVALL-ETQD-G------RG-------TDSL------
-------------------------------------KT-W--E-----KTSE--FDHQN
LAVS-------HSLGSSK-------------------------E---RLHTP QHLSYSKT
SE-DQLEDKNTQSFWGLPS-LHSESMNSIAT-VLTDSSL-----ISGCFN----------
----------------RFSDSPMLTHH----TTLP---------LSESQ-LH--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLSQSLSRSQ----SQPVSQANLQAQFQ-----PPNPVLSP-H---
-SQLR-----ICGVYFHSP-QNEAQPLEPSAI----------------------------
--------------------HCLEYNI------LKKEQE---RVWGLPTVVKNSQQEFCP
PPPNPSLVSQ-----ISKTHVPKSIS--IEKCFITSELQKKFEHHLRKRLILQR-----W
GL-PKRI-RESLLWINPQAEL-------------------PESPSS-K--SNYG----LS
W------------------IPFFKQQSKKDLHK---TILSQ-PGSFPAKQL--------E
-EKLL--KLCSKQGLEMV--------QKQQTWS----NT-KDTLD-NGLQS-DCETNLQC
H--------SDSPSCKPLG-----TSEVSQCQ-KKLETSLKEHLTT-RLNETIERQIT-S
TMSGSRYGPF----------PFTSC------------VNKE------EHKAQ-------V
PSDI--KDGHVKSIS---------------------------------------------
---------------------------------TA----K-----KSVKQQT--------
------------------------------------------------------------
-----------------------------------------------------SFDLDNT
SLEE---S-K-GNRHSSDVP----KMLAEV----LGKRLTSGKTVQCPQATKIIDK---K
VFVSNKV-----------G-------KGGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

MGNLVIPLGKGRAGRVESGQRIPPPAPRPSVECTGDDIALQMEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LFLLLLYVH-SDPPSPPP------
------------------GRKRSSREPQRERSGRSRSR-------KIS------------
----------------------------------------------AL----KAC--RIL
LRE-------LE-ETRDLNY-LLE------------------------------------
---------SHLRK---LAGEG-SS--------------------HLPLGGDPLGDVCKP
VPA-K------AHQPHG--KC-MQDPSP-ASL------S------PP----A--------
--------------------------PPA PLASTLSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKCP-----ATQPHVVFPPSPQPHG---PLAS---S--------
PPPP-----------------------------------------------DSSLAGLQC
GS-T-----TCPVP-----QSSPLHN----QVLPPP--TRVISGLG-CS-SDPIWD----
--------LY-CWREAAT---TW---GLST-----YSHGKSQPRHL--PDHT-SEASFW-
GDPTPKHMEVG--G-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-E-
KE--RKRADH---------------------------------------PHMTSLGKEWD
ITTL-------NPFWNVSTQ----------------------PQ---QLPRP QQVSDATT
VG-NHLQQKRSQLFWDLPS-LNSESLATTVW-VSRNPSSQ--NAHSVPLDKAST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQHFTPAWPQ
--SQPP-PLAEIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLGCSSP--
-PQIR-----GCGASYPTS-QERTQSVIPTGK----------------------------
--------------------EYLEWPL------KKR-PK---WKRVLPSLLKKSQAVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VVTSPELPEHWWQ-GRNAI-HQEQS---C
GP-PSRL-QASGDLLQPDGEF-------------------PGRPQS-Q--AEDTQQALLP
S-Q----------------PSDFAGKGRKDVQK---TGFRS-SGR---------------
--------FSDKGCLGSK---------LGPDPSRDQ-GS-GRTSV-KALD--EDK-EAEG
DLR--------RSWKYQSVSS----TPRDPDK-EHLENKLQIHLAR-KVGEIKEGWIP-M
PVRRSWLMAK---CAV--P---KSDTHRKPG-KLAS---WR---GGKAHVNTSQELSFLH
PCTQQILEVHLVRFCVRHSWGTD-LQSLEPINVW---------SGEAQAPPFPQSTFTPW
ASW---VSRVESVPKV--------------------------------------------
----------------------------PIFLGKRPQNGPGDNRTTSKSV--P-TVSGPL
-AAPPPEQEGVQR-PPR-----GSQSADTHGRSE-AFPTGHKGRGCS--QPPTCSLVGRT
WQSR---TVLESGKPKPRLEG--SMGSEMAGNEAWLESESMSPGDPCSSRA-LQV-----
-----LSIGSQWAR----AEDALQALKVGE-K--PPTWEVTLGASVRASSGS-VQEDLR-
STGALGTT-GNP-SASSVCVAQDPEQLHLKAQVVSEIALIVQVDSEEQLPGRAPGILL--
----------------QDGATGLC----LPGRHMDMLTAADRLPTQ-APLSTSQSVSGKN
MTAS-QGPCAL---LWKGGDS--PGQ-Q-EPGSPKAKAPQKS--QKTLGCADKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HRRPRTGE
QGHRS-KGPRTSEASGRSHPAQAREIGDKQERKYNQLQL-EKGQTPPES--HFQRKISHH
PQGLH-PRKGGT-RWEDVLQKGKPGA--DAF---------Q-SWGSGPPR-QF-MD----
CMADKAWTISRVVGQILVDKLGLQWGRG--------------PSEVNRHKG---DFRAQE
NV--PS-CC--HRGHCHQERSREMRALACSPKATPKG-HHCPVKNRGIRDRDSSW-----
------------------------APPPREPVS-PAGP-----HHHRPRMA--STSG--G
PH--PQ--LQELMSAQRCLAS---------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKCPVGRRRRPRGR------MKN-------------
---------------------------------------------HSL----RAG--REC
PRG-------LE-ETSDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--LPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--FPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-RWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-LFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNRMT-----------------PEKH-LNY-L--R-----NLAKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
WQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIQ-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRRQLE---GRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ELER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
CVRRSWLAVN---QAL-----PVSNTHVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQGLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPAWKQFQR-APR-----GIPSWNDHEPLK-PPPAGQEGRWPS--KPLTYSLTGSI
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVNEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLVSQVP-QGHLQSMPTGN
MRAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSVS--PFGENIKQI
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSRV--Y----
SSSAEAQGLMTAVGQMLDEKMSLCHARH--------------ASKVNQHKQ---KFQAPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TF----KDR--KCF
QRE-------VE-EERKLLP-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-HF--------------------RRLLCPDPDCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSTPSATPTEDLILSPRPKLSP------PPQLILSPD-LITSLADLFS-PSSLRDP--L
PPQPVSP---LDSKFPVDHS-----SPLRLPFP-LLPPPHI---QRAEP-SLQPEANFCL
NTTFSLDSTQCQD------ISQAMNPTDSCAHHYKPPIP-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPCAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEVSLG-
GHSLANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----KMLSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QEPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGCSS-----MFVFFNGITN------
----------TSLF----QESPVLPPP----QPLS---------LLSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SLPQTLPQGQ----SPHLTEVQSQAQHQ-----SPLPALLPSPP--
-FLIK-----ICGVCFHRP-QNEARSLTPSEI----------------------------
--------------------NHLECNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNLTLVRK-----SFKVHVPIAII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------LELSVS-E--SIQG----PL
H------------------SSSVEGQSLNVLKK---FGSST-PGTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DP-ETSSD-ENPRS-NSERDLDT
H--------MMHLSENHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVNED------HCVETSQEISFLS
SNKQKMLEAHIKSFRMRMLWGLP-RKVLESIEIF--------KSKEDLSTSFSNFDIPSS
ASF---ISRD-SKVDVSKSRRRS--SFQGEKWVTT---------SSVPVLDGPHPVTSPV
SKEGQDTLRRQYSDTDHDFIGSDSKDGASTLLRRGITDFQGEILESTNSL--P-ILGHSP
-LLTSPVDQEKQG-TLR-----REFADTDNDLTE-SVPTTEDGRQTF--LPPTHSVIDEV
SQKQ---TVP-ASRCSAEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRET------
FP---------------------------EICALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPTVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DTSIAFENLSSKDL-LTHPQGISSRD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPAAIKT-------VSPMRPKGGE
LGGGD-AGLGTSQLRRKSHAIHDKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWLKTF
LQRFNKPSIAYK-EQESSRAKGSSLS--SSV---------QN-RGRVTRRAAF-------
IGTTEGQKIRKDTRDSLEEKLGHRRGIDV-TCPQEPLSFPVEL-GKAQHNPDVQVRAEPV
LGYPCN-----STAPSCK----VTCTKSYSQQAIFVG-QNYPTRIRQITDKDRQSEKVEA
FKGKILCQR-HPQ-----------SI------------------LVCPAVL-TSAKS--S
VFSDVPLLTGQKMLPKH--FQG------GKFPPTK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------C--RPR
LRG-------LE-ELWNLFS-QLQ------------------------------------
---------SLLGP---LLDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------DSRSS---HEPMEDTAP-M-------LSPLASPD PR----TK-------
--------------------------H---LASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPLHTSD-------S--PSPPKAFPA
PPLR--D--------------------------------------------STLIIPSHC
DS-VA--LPLGAVP-----QSLSPCK-----DLTAS--VPAISGLG-GS-NSQVSA----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AQVNISE-E-
KE--NDGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSP QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIN-----NSGVACPAS-QNKVQAVCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDES-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGENSKEAQK---VK---------------FQ-----
LERDP--CPRLGQILGQT---------PQNLSR----GM-ESFPG-KVLGV-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENVLKVHVGR-KLGQMNEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------ACVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LKVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CEPGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLREQVLTKASD-MPE----SL
-LASSPACKQFQR-APP-----GIPSWNDHGPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQFSR----AVETRE---------AVPQPRVPLGTRMLANLQA-TSDDVR-
GFEAPGTS-RSS-LLPKMSVSQDPRQLCLMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLP-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDLNFICLSGLGL-------FILYLFYMV-LTLYSSPT------
------------------EKNNDTQKHQGRARRKRKS-----------------------
------------------------------------------------VTF-KDR--KSL
QKE-------AE-EERKLHS-FLK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLASSA SG----AE---SSFT
LASTPSATTPEDLILSSRPKPSP------PPPLILSPD-LITTLADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCARHHGPPTP-SALPP-ED----C--TVTQS
KSN-------LTVLKTFP-EMLSLGGS---GGSSTS--APTTKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANIIQPV--N-ISFLSH-DIPALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----NMLTSTAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVF-VQHGRSS-----MFVFFNGITN------
----------TSMS----HESPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SLHLTQVKSLAQPQ-----SPFPALPPSPL--
-FLIR-----VCGVCFHRP-QNEARSLMPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPVLVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQNKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--GNYQGCSQETA--------PKNHLLH----DP-ETSSD-EDLRS-NSERDLGT
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--CLPEKSHSQIKHR-NLAALVSED------HGVDTSQEMSFLS
SNKQKMLEAHIKSFHMKPILNLS-I-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPN---SHCLDIDPNFICLSGLGL-------FILYLFYMV-LTLYSSLT------
------------------EKNNDIQKHQGRARRKRKS-----------------------
------------------------------------------------VTF-KDR--KSL
QKE-------AE-EERKLHS-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQQL-LSWES-LKDAAP-----S---VSPLASSA SG----TE---SSFT
LASTPSATPPEELILSPRPKPSP------PPPLILSPD-LITTVADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPKASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCAHRHEPPTP-TALPP-ED----C--TVTQS
KSN-------LTILKTFP-EMLSLGGS---GGSSTS--APTIKGID-HS-CPASSE----
--------FS-WWQPHAE---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANIIQPV--N-ISFLSH-DILALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPTQLR-----------------RNYQ-LNS-S--R-----NMLTSAAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQAPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----HEPPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SLHLTQVQSQAQPQ-----CPFPALLPSPL--
-FLIR-----VCGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPALVRK-----SFKVHVPISII--PRDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SNHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--RNYQGYSQETA--------AKDHLLH----DP-ETSSD-ENLRS-NSERDLET
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--C-------QIKHQ-NLAALVSED------HRVDTSQEMSFLR
SNKQKMLEAHIKSFHMKPILNLS-ISGCCGAFPA--------RSVNP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------IENILCFP-----NSYTET
---GLSPD---SHCLHIDPNFTCLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGF-PDW--KSF
QRE-------EE-EERKLLS-LLK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLASSA SG----TE---SSFT
LASTPSATPPEDLILSPRPKPSP------PPPLILSPD-LITTSADLFS-PSPLSDP--P
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQSEASLSL
NTIFSFGSTLCQD------ISQAMNPIDSCARHHGPPIP-SALPP-ED----C--TVTQS
KSS-------LTILKTFP-EMFSLGGS---GGSSTS--APTIKGID-HS-RPASSE----
--------FS-WWQPHAE---DSF---SS-----NFVPSDFMEELL--SLHS-SEAFLG-
GHSVANLIEPV--N-ISFLSH-DILALL-ERQV-K------KR-------GDFLMQK-EN
GK--KPGSFPKQLR-----------------PNYQ-LNS-S--R-----NMLTSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQDIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----HESPVLPPP----QPLS---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQPQ-----SPFPALLPSPL--
-FLSR-----ICGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NRLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPVLVRK-----SFKVHVPISII--PGDFLLSSEERKKLQQYIRKRIIQCR-----W
GL-LRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SGSSF-PRSFHERSSNMLSM----
--ENV--GNYQGYSQETA--------PKDHLLH----DL-KTSSD-EDLRS-NSERDLGT
H--------MMRLSGNDS--------GERLGQ-KQLENALTVHLSK-KFEEINEGRIP-G
IVHSSWHSVK---QTI--CLPEKSQSQIKHR-NLVTLVSED------HCVDTSQEISFLS
SNKQKMLEAHIKSFRMRMLWGLP-FKVLESIEIF--------KSKEDLSTSFSHFDLPSS
ATF---ISRGDSKDGVSKSRRRS--TFQGEKLGTT---------SSVPILDRPHPVSSPV
GQEGQGTLRRQFSDTDHDLIETDSKDGASTSLRRGTTDFQSEKLESTSSF--P-ILGHSY
-LVTSPVNQEKQG-TLR-----REFSDTDNDLTE-SVQTTEDGRQTF--LPPPHSIVDEV
SQKQ---TVL-ASRCSAEL-P---IMEAGAGCESWDKRKSSFHNVDRLQGSRKT------
FPV---------------TS------------ALQSQTRNNLTTSKSGSCSL-TNVKAS-
TS---NET--E-IFPPRISVPQGPKSSYLKNQMLSQLK--LVQRKHSQPQSHFT------
----------------------------------DMSFALDNLSSKDL-LTNSQGISSGD
MGTS-QVVHVH---LEDRGIR--VAQ-KQEPRVPTCV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAVNR-------VSPVRPKGGE
LDGGD-AGLGTSQRRRKSLPVHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSISYE-EQESSWEKGSSLS--SSV---------QN-IGRVT-RAAF-------
TGTTEAQKIRKDTREFLEEKLGHRHGIDI-TCPREPLSFPVGL-GKAQHNPEVHVRAEPV
QGYPCT-----YRAPSCK----VTRTKSCSQQAIFVG-QNYPTRIRQIIDKDRQPQKVEA
FKGKILCQS-HPQ-----------SMPHRKPVPHPNPTCRRQVSLVRPAVP-SSAKS--P
VFSDVPLLTGQKMLPKH--FQG------GKFPPTK-------------------------
-

-----------------------------------------MENILCFL-----SSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYMV-LTLYLSPT------
------------------EKNNDIQKHQGRARRR---RKSV-------------------
----------------------------------------------TF----KDR--KRF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-RF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----C---VSPLPSG ASV----TE---SSFT
LSSTPSAISTEDLILSPQPKLSP------PPLLILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-NLHPVASLSL
NTIFSLDCTICQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILRPFA-EMLSLGGS---GETSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPHAK---GSF---SS-----NFVPSDFMEELL--TLQS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ERQV-Q------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----KMLASIADKHD
MVEF-------FPFGANKGK----------------------LE---GQHIH QDPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-GQRGRTS-----MFVFFNGITN------
----------TSIF----HKFPVLPPP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQHQ-----SPLPVLLPSPP--
-FLIR-----ICGVCFHRP-QNEAQSLTPSEI----------------------------
--------------------NLLECNV------LQKVQG---SVWGLPSVVKKSQEDFCP
LAPNLALVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLHPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSSI-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKDHLLH----DP-ETSSD-EDPRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSED------HGVDTSQEISFLG
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDPNFICLSGLGL-------FTLYLFYMV-LTLYSSLT------
------------------EKNNDFQKHQGRARRKRKS-----------------------
------------------------------------------------VTF-KDR--KSL
QKE-------AE-EERKLHS-ILK------------------------------------
SFG-PPVSCSHLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQRL-LSWES-LKDAAP-----P---VSPLASSA SG----TE---SSFT
LASTPSATPPEDLILSPRPKPSP------PPPLILSPD-LITTSADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCAHRHEPPTP-SALPP-ED----C--TVTQS
KSS-------LTILKTFP-EMLSLGGP---GGSSTS--APTIKGID-HS-RPASSE----
--------FS-WWQPHAE---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANLIQPV--N-ISFLSH-DILALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPKQLR-----------------RNYQ-LNS-S--R-----NMLSSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVF-LQRGRSS-----MLVFFNGITN------
----------TSIS----HEPPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQPQ-----SPFPALLPSPP--
-FLIR-----VCGVCFHRP-QNEAQSLMPSEI----------------------------
--------------------NHLEWNV------LQKAQE---SVWGLPSVVQKSREDFCP
PAASPALVRK-----SFKIHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SGSSF-PRSFHERSSNMLSM----
--ENV--GNYQGYSQETA--------PKNHLLH----DP-ETSSD-EDLRS-NSERDLGT
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--CLPEKSQSQIKHQ-NLAALVSED------HCVDTSQEMSFLS
SNKQKMLEAHIKSFHMKPILNLS-I-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENVISFL-----HSATEP
---WLSFAHLPSAFMDIYPKCIFLSAVGV-------LLLYLRYLL-LKPFLP-T------
------------------WDNRDLRKQQSKA--KKGRR----------------------
---------------------------------------------ASS----KEF--RIF
---HR--E--AW-ERRKL------------------------------------------
----LSVVQSPCGR---LYDAS-HF--------------------RQVLCPDPCCDVCNG
ATA-K------VSHL-LSRAT-LEDGA--ASASS---V---PSTA SV----TE---NSFS
LSPPRSLSPPGCQTSSLSPAPSP-------PPTTLSAN-KVTPLEDILL-YAPQGDA--L
PSEPLLL---PGTDSPLGHI-----PSHPL--------PTF---PQTEGSLHLET-TPSV
VGSP----------SEWFVNATTNEEP-C-------------------------------
------------------------------------------------------------
---------------GYL---SG---FS-S-----QSECLVNA--------H-SSKAFWG
RQTTDYFTAPG--K-LSFPSP-KVLVLL-ERQD-E------SQ-------ADFLVLK-DG
EE--KAETFQKA------------------------LTT-W--E-----EIPESATELQN
SGGS-------LPLGGSRSM----------------------LS---ELITH QGLAQAQT
TE-DQSEPKFTQHFWGLPY-LHSESMNAIST-LSTHCSS-----TYIWFN----------
----------------GTPDSSVLNLS----TPLS---------LPENP-SQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MLAQSQ----SQGVLLAMSQNQFQ-----PPIPETSSSSQ--
-SQLR-----ICGVYFHRS-QDKTKTLLQAQI----------------------------
--------------------HHLECSI------MTKVQE---RVWGLPSVVQKSQEDSCL
LPAKPSLVRQ-----SSETHAPRSIP--PGDFPLTDAFRKKLERHLQKRFILQR-----W
GL-SQRI-FKSQPWVNPDLS-----------------------ESS-Q--CSYG----LS
W------------------ASFFQHQESKD-PH--DTVSNQ-PGSSQERYSESLSL---E
-GKMV--KAQ-GQSPEIA--------QR-CLWS----NS-RGALG-NGLQS-DCKTNLRS
H--------PGSLSG---------ISQVRQCQ-KKLETAL--------------------
------------------------------------------------------------
--HL--KDGHVKSTY---------------------------------------------
---------------------------------TM----T-----KSVLHQA--------
------------------------------------------------------------
-----------------------------------------------------SIGLDNI
RLKE---S-E-GNRHSPDVP----RISTEAGPVPVGKQLDFSKTVQEPQGTQMNDE---N
IFVSNKV-----------S----NIVKRGQLSGLQPQPTKILNTSQCKSAQG-ADGNTT-
KVQS-TLV-AGR-AQKEISGFQESQTSDCNSQVSREEKFKAESRLPIQALGPPN------
----------------------------------DMLPASEKFTYKP-LLMHDQSLSSGP
MNAP-QVQ-------------------QQEPWMPPH--TLG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGQDK--DI-PLSAKK------VWPATWKTKE
LGEGI-TRPGTLQASGKSCHAQASPGQGNYREKPSHP-LPVKALTPPEH--QFRKHIKHF
LQWLS-PDRKCK-GQETLFLRRGPSPS-SPA---------QD-PELWKARATF-------
PGNTVAQKAMRDPGRVPKEQLGHRHIAIDTMRPHVPLSPPIKPV-KTHPKKASWVPAEPV
QGY-PF-H---HQATCPK----APSPRSYNQATAFVG-QKR-----WVEDRGRLSQKGVV
LQP-------R------------PPAPYR-------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
---WLSLS---STMDTMDMIFAIVCGLGL-------YLLLLPFID-SHLSLLPP------
------------------NIKFT-RKPQRQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-RYRKKF---GT----------------------------------HSR-
KDFKAW------------------------------------R-------ESLEKLK-E-
KE--KDESFLEEIS-----------------PGYH-LNY-L--G-----NMFKSPSTKQD
RTIL-------PPFWNLKEK----------------------SE---QQMTTQKLSYPTI
LG-DNFQEKYNQLFWGLPS-LHSESLVATAW-IPQASSTL--PSPFFLFNVIST------
----------AYPVQMRDQMSPVHSCT----RPLS---------YLDLQ-SPPLILSPP-
-QFQAP-APNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------SP----LP-----AQLPSSL-PYT--
-SDYG-----DYGPSCSQS-QSQSQC-LPTEI----------------------------
--------------------QHTEGHS------LT-KLE---SRLPLSLMVQRPQEVYDV
LAPNLSQD-W-----A------VSIL--PDNFPISCELREKLEQHIQKWLIQHR-----W
DL-PRKIQ-ESLEVMQLQNTV-------------------TEPCQT-R--DKPG-----P
S-R----------------SSVSMGNHSKDDHK---VRF---------------QI---K
--KES--GKNLGPILGNI--------SK-DPNR----YL-EKAPV-TLQGT---------
----------------------------------N LLNTLKAHVGT-KSEQINQGLIP-L
NVRRSWLAMN---DVF--FMS---DIQMETK-KLASSKTSE------KSVNSSQKLTFLD
PGTHQALEEHIVRFWVKHRWGLP-LKMLKPINLF--------KLKKFESLPDALCDLPSS
TTS---ISGTSSAVEV--------------------------------------------
----------------------------VGFLGKPCQTCLREVV-IEDSS--P-SLGSLL
-LVASPSCKGIKR-TLR-----AFPSGADHEPSQ-VLPNKSESKHHS--ETLKHKVMDTP
SQSG---T----------------------------------------------------
------V-----------------------------------------------------
LEKERETQ--VL-LLPRRTSVQNPGAHSYQAKTVSEFPPSVETESASQPQVYTGAV----
--------------LLPE-------------HPRSTLLPADTLASLGLG----------D
---------IV---MVGGDNS--LVQ-Q-KSSTPNHQVSP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQIK--VLAASYRG-------EATKRPSKGN
H-EGP-KL------------TSVKEKEDKFIRKH-QPLP-KPTQVPPES--PFQKLVSRF
LQWIH-PKKAIK-GQESPPKKGKPTA--ATA---------QSPQNQ-VKKPRV--D----
SNVAEAQELTTAIGQMLEKKMMQQRKLC--------------ASKVKQHRE---TPPPPA
PQ--SS-CG--HKPVSGSEQRRAPSHP-----ANSSY-QWYSTKERHIKSQPSQKN--VP
FRNEPQA------------HQNPSPLPRNTTLN-LVSS-----SQNGTIMP--TVSS--Y
H--LCC--PRHCAVRRS-IYS-QLQNSSLVFTSRKA------------------------
-

-----------------------------------------MEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LYLLLSYLH-SDPPSPPP------
------------------GRKRSSREVPRHR---PLHH------NP--------------
------------------------------------------------------------
----------LE-ETRDLNS-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HLPLGGDPPGDVCKP
APA-K------AHQLHG--KC-MPDLSP-TSL------S------PA----A--------
--------------------------PPA PLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPLSTQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----TRPVP-----KSSPLHS----QLLPSP--TRVISGLG-RS-SYPIRE----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDQP-LEASFW-
GDPTPRHVEVG--V-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-G-
KE--RERADH---------------------------------------PQMTSLGKEWD
ITTL-------DPFWNVSTE----------------------PQ---HLPRP QQVSDATA
VG-DHLQQKCSQLFWNLPS-FNSESLVATAW-VSSKPSSQ--NAHSISLDEAST------
----------SLPGEPEVEVSSELSQT----PSSS---------QNAHS-V---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------SLD------KAST
--------------------S---------------------------------------
---------------------------------------LP---GE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------P--------------------
------E-----------------------------------------------------
------------------VE----------------------------------------
------------------------------------------------------------
---------------------------------------------------VSSELSQ--
----------------TSVATKVT----SNAR----------------------------
----------R---MWPSSRP--QGS-L-PPGT---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTES
---GLSPG--LAHCLDIDPNFICLSGLGL-------FMLYLFYVL-LTLYLSPP------
------------------RKNNDIQMRQGRARRRK---KCR-------------------
-------------------------------------------------TF-KDW--ITF
QKE-------AE-EERKLVS-FLK------------------------------------
SFR-PPASCSPLGR---HHDTT-RF--------------------RRLLCPDPLCMVCNR
TTA-E------VQRL-LCWES-LKEPAP-----S---VSSLASAA SA----TE---SSFT
LASAASATPPEDLIVSPCPDPSP------PPPLILSPD-LITPLADLFS-PSPLRDP--L
PPKPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---QRAEP-YLQPEASLSL
NTIFLFDSTLSQD------ISHAMNPCDSCTFHYKPPNS-FALRM-QD----C--TVSQS
KAS-------LIILKPLEKETLSVGGS---GGSTTA--APTIGDID-HS-CPASAE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMQELL--SLHS-SETSLG-
GYSVVNLIVPV--N-LSFVSH-DIVALL-ERQV-K------KR-------GDFLMCK-EN
GK--KPGTFPKHLR-----------------PNYQ-LNS-S--G-----KMLASTSEKHG
LTTS-------LPFSASNRK----------------------VE---GLHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLNPTVL-LHRGRSS-----MFVFFNEIAS------
----------MSTF----QEPPVLPHP----QPLS---------LPITQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SL--------AQHP-----SLPTAQLPSPL--
-FQIG-----ICGVCFHKS-QNEGQSLTPSEI----------------------------
--------------------NHLEWNV------LQKLLE---SVWGLPSVVKKSQEDFCS
PAPSLALV-K-----SFKACDPIPIS--TGDFPLSTELRKKLEQHLRKRLIQHR-----W
GL-PRRI-HESLSLLRPQSPI-------------------LEISES-E--NSEG----PL
H------------------SSLVEGQSHNDLKN---FKSRK-RRSFHKRSSNMLSL----
--ENV--GKLQGYSQENG--------PKGDLLH----EP-ETSSE-EDLSS-NSESDPEG
H--------MMHLPGNDL--------GVSLGQ-KQLANALTVHLSK-KFEEISKGQVP-W
SVRSSWHSVK---QTM--SLPEKSHSQINHQ-DLAALVGED------YCVDTSQEMSFLG
SNKRKMLEAHIKSFHM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLLFPL-----KLLSAS
---SLNTP--SFTPWVLDIFLTLVFALGF-------FFLLLPYFSYLRCDNPP-------
S------------PSPRKRKRHLVSQCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--LVP
P--------------------VSC------------------------------------
---------SLLGP---HLAKG-DF--------------------GQLSGPDPPGEVGKR
TPD-G------ASQSS---HEPMEDAAP-I-------VSPLASPD PR----TK-------
--------------------------HPQDLASTPPPG-PMTTSV------SSLSAS--Q
PPEPS---------LLLERP-----SPEPPVLFPHPPHTPD---PLACS--PPPPKGFTA
PPLW--D--------------------------------------------STLLTPSHC
DS-VA--LPLDTVP-----QSLSPRE-----DLAAS--VPAISGLG-GS -NSQVSA----
--------FS-GSQETTK---TWC-----------VFNSSVQQDHL--SR----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QRDTTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTSMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPMK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPERPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQERL------------TSIL--PENFPVSPELWRQLEQH--------------M
GQ-RGRI-QESLDLMQLQDEL-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAET---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
NLR--------KPLRSDSGSD----LLRRTER-NHIENILKAHLSR-KLGQTNEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAVPKSRK------ACVNTAQVLSFLE
PCTQQVLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------QLEKVSSLSLIQLAGPSS
D--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLGEPPMASLRKQVLTKPSVHMPE----RL
-QASSPACKQFQR-APR-----GIPSWNDHGSLK-APTAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AVPQPTVPLGTCMRANLQA-TSEDVR-
GFKAPGTS-KSS-LLPRM------------SEPVSEFEPGMATKSETQPQVSAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QGHLQSMPTGN
MQAS-QELCDL---MSARRSN--VGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSP--MFPPTHKR-------ENSRKPNLEK
HEEMF-QGLRTPQLTP------GRKTEDTRQNEGVQLPP-SKKQPPSIS--HFGENIKQF
FQRIF-SKKERK-----------PAP--VTA---------E-SQK---------------
------TRLTSAVGQILEEKMSLCHARH--------------ASKVNQQRQ---QFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKN-QSHPNRDRQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PFSP-----PQHRPKTP--GASS---
-HHHHR--PRQCLFQGR-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPN---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKVRNCGRVPLSSLHIT-------------------
----------------------------------------------YYSGF-SDW--KSL
QRE-------EE-EERKLLS-LLK------------------------------------
SFG-PPVSCSPLGQ---HHDTN-HF--------------------RRLLCPDPVCRVCNR
ATA-D------IQQL-LSWES-LKDAAP-----S---VSPLASSA SA----TE---SSFA
LASTPSAAPPEDLILSPRPKPSP------PPPLILSPD-LITTVADLFS-PSPLRDP--L
PPQPVSP---LDSKFAIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISRAMNPIGSCARHHGPPIP-SALPL-ED----C--TVTQS
KSS-------LTILKTFP-EMLSLGGS---GRSSTS--APTIKGID-HS-HPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEAFLG-
GHSVANLIEPV--N-ISFLSH-DILALL-ERQ----------------------------
----KAGSFPKQLR-----------------PNYQ-LNS-S--R-----NMLTSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----RESPVLPPP----QPLS---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRDQ----SPHLTQVKSQAQHQ-----SPFPARLPSPL--
-FLIR-----ICGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPELVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQCR-----W
GL-LRRI-HESLSLLRPQNKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--GNYQGYSQETA--------PKDHLLH----DP-ETSSD-KDLRS-NSERDLET
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSE-KFKEINEGRMP-G
TVHSSWHSVK---QTM--SLPEKSQSQIKHR-NLVTLVSED------HCVDTSQEISFLS
SKKQKMLEAHIKTFRMRMEENFP-PQNNSILV--------------------ENLDSPQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYMV-LILHSSPS------
------------------EKNNDIQKHQGRARRR---RKSV-------------------
----------------------------------------------TF----KDR--KNF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCGPLGQ---HHDTT-CF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----C---VSPLPSG ASV----TE---SSFT
LSSTPSAIPTEDLILSPRPKLSP------PPLLILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHYKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APITKALT-IH-ALHLQN----
--------SS-LVAASCQ---DSF---SS-----NFVPSDFMEELL--TLHL-LEPLSG-
GHSVANVI-----------HH-DILALL-GRQV-K------KR-------YHFLMWK-EN
GK--KPGSFPTQLR-----------------QNYQ-LNS-S--R-----KMLASIADKHD
MVEF-------FPFGANKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIF----HKFPVLPSP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQHQ-----SPLPVLLPSPP--
-FLIR-----ICGVCFHRT-QKEAQSLMPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSII-PRTLHERSSNMLSL----
--ENV--GNYQGCSQETG--------PKNHLLQ----DP-ETSSD-EDLRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTAHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSED------HGVDTSQEISFLG
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MKKILSIFNSTILTSATES
---WLSFG---SVFMNFYPKCIFLGALGL-------LFLYLRYRI-QKFYLP-K------
------------------QTSQGIRKQQGRA--KKEKR----------------------
---------------------------------------------TSF----NEF--RNL
---HG--E--AR-EWRKL------------------------------------------
----QSVVQSPRGQ---LYDPS-YF--------------------RQVLCPNPSCDVCDG
ASV-K------VKRL-LSWAS-LEDCS--ASVSS---M---ASTA SV----TE---TSFT
PSSSLSPSLSGYQTSSFSFAPSP------PPPSVLSTN-ELASWEDILL-CTPQVDS--L
PPEPAFA----GAGFPLDHI-----LPYPLSHSPSVAQPAT---QQTGGLLRLEETIQSL
AGSH----------GDLFLDATTSH-A-FL------E-----------------------
------------------------------------------------------------
---------S-SQQSGGI---YN---SSPP-----QSKCSVSQEIP--NHHH-SPEDFGG
RQASPHFPVPE-----------DLLKIL-ERQE-E------SQ-------ADVLVSK-DR
EG--EAEPFQKA------------------------LAV-W--E-----KRSQPSAELQN
SEDS-------FPLGGSRAI----------------------LR---ELNAL QGLAQVQT
AE-GQLEATPSQHFWGLPY-LHSESMSCITT-VSSHCSS-----MCIWFN----------
----------------RATDSPALAPP----APLS---------LPDRH-TQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------TLTQTQ----SGSIHLATAQSQLQ-----P-MPMLSPSSQ--
-SQVR-----VCGMYFRSS-Q-EMKTLLQPEI----------------------------
--------------------PYLEYNM------MAREQE---RAWALPSVVQKSQEKVCL
LPAKPSLAIQ-----AFKIQTPRSVP--PRDFPLTDGFQKKFEQHLRKRFILQR-----W
GL-PQGI-YKSQLWVNPDPP-----------------------ESS-W--SSHG----RS
G---------------------LKHEDHKEPPK--PPVLNQ-AGSPQERCSGSVST---E
-RKPV--KVQ-EQTVEII--------QK-YLCS----NS-KSALD-NGLPSSDQEMNLQG
R--------SSSLSDKPSE-----TSQVSQFR-KKFEAAPQEHLRG-HIDGTNEDQVP-V
TVPKLGHRPL----------HFNSC------------VGKK------EIGAE-----TQP
PPEN--KDEHTKSTQ---------------------------------------------
---------------------------------RI----A-----MSAVQQT--------
------------------------------------------------------------
-----------------------------------------------------AVVLDTT
SLEV---S-E-GKRHSPKVP----KMLVEAGPVPLGKSLSSSKIIQGPQGSKMDDK---N
IFVSNKV-----------S----NLVR-EQLSGLHPQPIKMLSTSQSEHSEE-ADGSTS-
TTQSSILF-FGR-VPEERSGPQESQASDFIYQVFRKEKFKSEGSQPILAPEPPK------
----------------------------------DELPVLDIFTYKT-LPVHDQSPSSAP
MNAA-QVE-------------------QQEPWVPPH--ALG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGLNK--DT-PLSAKR------LSPAPRKTEE
LGAGG-AGPETLQPDGK-----DSPTQGNSGRRPIPS-LPGKALSPPEH--QFRKHVKHF
FQWLS-PDKKCK-GQEALLKRDASPSLSVPA---------ND-PE-LKVKATS-------
PGNTVAQKVTRDFGKVPKEQLGQRHGASDTLRPRVASSPPTKPV-KTKPKKEYWVPTA--
QGR-QF-Q---HPAPFSK----LP-----SQATAFVG-QKR-----GVAERARQPQKCEA
LQP-------R------------PPGSHRESELRP-NLLLSRAGKVPRGTP-PFAVG--T
MLADMSRLCEQKILAQN--FSG------KDFVPQK-------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKVRNPQSR---------------------------
------------------------------------------------------------
----------PT-ELDSLLS-FYY------------------------------------
---------YLLEP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--PPPPNGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-WWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNQMT-----------------PEKH-LNS-L--R-----NLVKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
LQ-QSFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--RSPPFLFNEMSY------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GRLALPSEVQKSQDVFSV
STPNLPQESL------------TPIL--PENFPVSPEIWRQLELHIKKWIIQH------W
GK-LGRI-QESPDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LESDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-HLGQTNEGLIP-V
RVRRSWLAVN---QAL-----PVSNTHMKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQVLGAHIVRFWAKHR-------VLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPACKQFQR-APR-----GIPSWNDHGPLK-PPPAGEEGSWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----ARETRE---------AEPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVSEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QGHLQSMPTGN
MWAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSIS--HFGENIKQF
FQCIF-SKKKSK-----------PAP--VTA---------E-SQNTVKNRSCV--Y----
SSSAEAQGLVTAVGQMLEEKMSVCHARH--------------ASKVNQHKQ---KFQVPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SL-------------------------------------------------------
-----------------------NRKCPVRRRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--VLP
GH------------TRLVPP-VSC------------------------------------
---------SLLGP---HPDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------ASRSS---HEPVEDAAP-M-------LSPLASPD SR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPLERP-----SPKPPALFPHPPHTPD-------R--PSPPKAFPA
PPLR--D--------------------------------------------STLIIPSHC
DP-VA--LPLGTVP-----QSLSPRK-----DLAAS--VPAISGLG-GS-----------
--------------ETTR---TWC-----------VFDSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PVLLNS-NGQNVM-------------ER-------AKVNISE-E-
KE--NGGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSP QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--HSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLP---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------RPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIN-----NSGVACPAS-QNKLQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------PSIL--PENFPISPELRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDES-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LEGDP--CPHLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
DLR--------KPLRSDSGSD----LLRRIER-NRIENVLKAHVRR-KLGQMNEGFIP-V
RVRRSWLAAN---QAF-----PVSNTHVKTS-NLAPLKSGK------AYVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-PR----------------------------LAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------AMFLSEPPMASLRKQVLIKASD-VPE----SL
-LASSP--------APP-----GIPSWNDHGPLK-PPPAAQEGRWPP--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AVETRE---------AVPQPRVPSGTPMLANLQA-TREDVH-
GFEAPGTS-KSS-LLPKMSVSQDPRQLCLMEEVISEFEPGMAKKSETQPQVCATVVLLPD
EQ------------------------------ASVLPLAAENLAPQVP-QGHLQSTPAGN
MQAS-QELRDL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--IIPPTRKS-------ENSRKPNLER
HEERL-EGLRTPQLTL------VRKTEDTHQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKKKSK-----------PAP--VTA---------E-NQKTGKNRSCV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARQ--------------ASKVNQHKQ---EFQAPV
CGFPCN-----HWHPFYSEHSRMLSYVV----TTLKS-QSCPNRERQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTP--GASS---
-YHHHC--PRHCLLRGG-I-----------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KT-------MTCQTVE-KT
KK--EEDIFSDPKR-----------------SECQ-LKA-P--W-----NLLGSTVIDED
IPVP-------QVSLNVKGK----------------------LG---KLGISEQQMRMTI
QG-RGLGQKHSQLFWGLPS-LHSESIVATLLVLPLNSYSL--EPQLMLFNGVCR------
----------AVTAPVLGYGCPAPPQP----HTV---------PLTFLH-PQPQPQPQPQ
P--QPQ-PQPQP------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSN----AHVQ-----SALAPLQ-SPS--
-LPCG--------SPPQMP-QDSTVSGVVHGN----------------------------
--------------------KDLQCHS------LENHQH---SLWGLVPKSQQYGTPFGL
LVPSLPLVSQ-----PSQNYASVP-R--TGHFHSGSELQGNLESYGPNNPIPPW-----C
YP---------------QFKT-------------------TETSPH-S--CKCV-----K
P-Q----------------RTVHWDQSCSNLRT---GEL-----SFYETVSMKPQL---R
--QDV--AKNLGQILGRC--------PLGNPQM----IS-GCYIL-NNLRV-IPET--QM
EWA--------CHSGVGLEHEGDGISRKSLDQ-RQTRSILRLHISR-KLWQITMGRIP-I
KVCCSWLAED---STL--WNLPP---------------GSF------YCNTAVLEIPFLD
PKTQKMLEAHLIRYRVSQKWGLP-IKVIESIKFY--------MLREAKTWPLPQSDLSLS
SNS---TSGIDVKSSF--------------------------------------------
----------------------------PYPLRENTNLYHNDRLETANST--S-IIDHLP
-LTISRIDGEGEW-PLG-----KSHSSNDYEVTE-KIQKTEGDTP---------SINDNV
SQND---AELPSRPGQ--E-Q--PVKEQVAGSKSQSEMASCSSHLEVIEGKQTVG-----
-----KHPPHMPIT----PGMLHEILGARNVSV-LSGSDPSSQAGSSTRKNE-D----S-
DEPDSVVT-TAH-NTSRVLLPED------PAQLFQELKLKLEKQSQGHTEGYET------
----------------------------------DGSFTSNSLTGYSM-S-SSNSVSSSE
ASIF-RSFHPQ---LCNTGIS--LDP-WREPSV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KHNT------------------MNLPVPRKEN
GKSET-RKTQTSKAGKKSQPITGKS-------------D-NQKSQPLES--YFRKKIGQL
FQWLY-SSKDNT-R-----------------------------HRTEKDRALF-MS----
CGPPEAHELMASLGKLLEDKLLYGQRSG--------------FLEWSQKKCLQAQ-SDPT
NG--QP-SK--HEA-ACAHHGEGKYICYCPQIATAPG-ASCML-SPRQTHPHVS-FEQQ-
PQFYSYLPS-LET-----------RDP---------------------------------
------------------------------------------------------------
-

------------------MLPCRDRNCHCVGRYWHKVSIQKMENFFSL------KNILAT
---LLRSS---STSWLIDIILAFFCGLGL-------FLLLLPCLQ-SNPYLPPT------
------------------RKYRNIRKHQVEMKGRSQ------SRKKRE------------
----------------------------------------------SL----KAC--RDC
LEE-------LE-GTRHLVS-LLQ------------------------------------
---------SHLGR---LPDKS-SF--------------------HQFSRQDLLDEVCKA
VPA-G------AHQPCG--KTPVEDTAP-AMP------L-L APLTK--------------
--------------------------HCLPLASIISPG-PTTSSVSVHS-HTSLSAS--Q
PLEPF---------ISPDIL-----SSSTVALSSPPLYLPD---SEAC---P--LTASSA
PPLL-----------------------------------------------DSVLTLTQS
DSSMA--LPLGPAP-----QSLFPHPPW----SASL--IPAISGLG-H-SHCPVSA----
--------LS-WWQAAA---KAL---YLST-----SSEYKSQKKHL--SHNP-AGASLW-
ISPTDRQVEAS--S-PFLLNS-HEQKLL-DIQV-T------KR-------GEIKIWK-E-
KE--KDESHLKQMS-----------------PDCH-LNS-L--G-----NMLESLHAEQN
TTTP-------QAFWSTKDK----------------------PG---QLPGP QQFSYPKV
LG-NNLQQKCNQLFWGLPS-LHSESLVAAVS-IPETSSVP---QSPFLFNRISH------
----------ACPVQMQAKISPLLFQF----QPFS---------HLEFQ-SQPFIPTIP-
-QFQPP-PLAQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------IQTQAHLK-----SSLPILPSSSS--
-AQIR-----TFGLSCPTA-QNKPQSLTPTEI----------------------------
--------------------QHSEWSL------LQKQLE---NGRTLSSVVKQSEEVFNV
FPSNLPEDSW-----V------VSIL--PENFPISLELRKQLEQHLQNWLIQHQ-----W
EL-PQRIQ-ESSEIRQLQGEL-------------------PSTCQA-K--GKDR-----P
P-Q----------------PSLFTGKSSKDAQK---VRF-----------QLSQGV---G
--K------GLGHILGKV--------PK-DLSR----NS-ESSVV-KFQEV-NSEES-EN
---------DLRLLRSDSGID----LLRSLD--KNLDNILKGHLGR-KLGRNSKGLVP-V
NVHQSSLDVK---HPS--SKS---DTLEETS-NLGILKGWE------PCVNTGYRVSFLD
PDTQEELEEHITRFRVKHRWGLP-LKVLKPINLF--------KLKKPQPSTMQF-VSAPS
ATY---VPESHSTVKF--------------------------------------------
----------------------------AEFLGKPPQAHSRE-VIKEESV--P-TLIRPL
-LTPSPVYKENQR-VLA-----NIPCDDYHGHSE-ASLTALEGRSPS--QSFKLSVVGRT
WKTE---TVKWTKRDS--LES--HPGSTMARNEPREESGSQASQDPYQRVK-MME-----
-----VNLGSQSLR----SEEAREAAEPKESPAFHQQSRVTLGTKVLTKPQT-TSVHRR-
NLEALG-ASKHS-PLTRMSVFQHLGEPCLNTDVASKFKSKVKAPSNTQLQHCPE------
----------------------------------HTCLAADNLTSPVSHCH-PQRLPTRD
RLAS-QTLHGF---KAAQRRS--LGQ-Q-EPQISKLQDSG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSK--MRAPTYKR-------EDCRRHKPGE
HKESF-KELGTSQAGNMRRPALVWGIVESFKSKCLQVMP-EKKQGPQES--LFRKNIRLL
LKWIF-PSRKVK-GG-DALQNCKPKS--ATA---------QS-EGPVESRSIL--N----
SENAEAQALMTAVGQILEEKMTTHHGLH--------------ATKLKEPKQ---ELQAPV
CR--CF-CY--HRLPSYPQQGKNMGYTACSHQATSRG-QSCSFREREVRHQQSSKS--VR
FNDEQLSPR-CLP-----------TSSPKKTVT-LVCP-----CHYGPRIP--GAPV---
-HHQHC--PRHCHLWGG-VLPAQP------------------------------------
-

----------------------------------------MMENSLFSL-----KSTFDI
---WLNSC---STYWVTDTILAFLFGLGL-------FFLFLPYLE-NNPSFPPP------
------------------RKHGNIKPQT-EPRRRRRSR------KKNA------------
----------------------------------------------AV----KAC--RDC
RKE-------LE-EVRDLTS-LLQ------------------------------------
---------THLGR---FPEKG-NF--------------------HQLSSQDAPGKVCKA
APA-G------AHQPYR--EE-T--------A------P-TVSPA PL----TE-------
--------------------------QPLPQASTLSSD-SVPSSFSVHS-DSSLSAS--Q
IPESS---------LPLDSL-----SPQPLAVSPTPPCFPD---AVAC---PAPPTASSV
PQPP-----------------------------------------------ATMLNLSQG
ES-MA--LPLGTIS-----HRSSLPSPWR----------PAISGLL-HS-SCPLSA----
--------LS-WWQGAEK---TW---SSST-----LTHFESQKEHL--SSHP-EEASFW-
GDLTNRQVEAG--S-LSFVNP-DVQKLL-EILI-T------KR-------VELKIWK-K-
KG--KEVE-----------------------A----------------------------
------------GFWIIKGK----------------------PE---RLLGPE KAPYPGT
LG-DHLQRTCSHLFWGLPF-LHSESLVATVT-VPGSPLEL----HPILFNECSK------
----------TKPLQIPAKVTSRPSLA----QPLT---------STVAQ-AQPRPLIPTM
AQFPPP-PQGHMETQAQHLPSSTTIPQCQP SYRAYMKTRVQPLPLTPTMPRCQAQTRTHI
------------------------------------------------------------
--------------------------------------QTQVQPQPLST-----------
------------------------------------------------------------
------TIPQCQPSPRAYMKTQVQPLPLTPTMPRCQAQTQAHIQTQAQPQPLSTTIPQC Q
PSPRAHMETQVQPLPVTPIMPQCQ----PSPRFQLEATAHMS-----PSLPIQPSSSK--
-PQIR-----YGEVSYATA-QSKGQTSVPNAI----------------------------
--------------------QNLEHHF------LIKQLE---SRKIIPSLVKRYQHAFSQ
VTHNHSQESR-----PSQAHISVTTP--FG-DLIRPEVWEKLDHHLSKRFMQQ--Q---S
DL-PCRI-QASQKVMQTQGKF-------------------PKLCQV-Q--AKKG-----P
S-I----------------PSAVLGKSSQDTQK---MRSRS-SAR--------IPP---E
--KDL--CQDIEQSVGKI---------VKDLYM----IS-ANTTV-KVPRV-KPE--SQ-
-------------------------RELSPDR-KHPEDLG-VLMGI-NTK-IQESPNP-V
GVHCLRLAAN---HIV--DLSGESNVYQETE-NLDSSQDGE------ASMNTFHEPLVLS
PYVRQELEAYILKFQVKHMWGLL-LKVLKVILRL--------KLRKAHC--IPLPGSALK
ATR---ESGDHSKAQS--------------------------------------------
----------------------------PEMFGKLPQPQAGKRMITAEAA--S-PMETAF
-PTPSWASEETR----------GPLPGGILKPSE-VPLTRQGDKPPS--QTPMYNFVGRI
WHNE---CIMGAEK-G-NLEPWSCPSPATVRNVPQEEAGGWAFPDSYSSVT-VVE-----
-----LDERSQSPM----EQE-----AIE--G--DSGWKSTFEPCLLIKSQS-NNMDLR-
-SQSPKFN-KCF-SLNTKSVASSLEDLHFDAQF-RKLECQGFTDRQKQAQGQATGLLL--
-------QDCETGA------TGTL----LKNCRSDKFIAANNLASEES-LSCSQTLSSGG
TTNS-QMLYDV---SSTGGSS--QGQ-Q-EVLR--RQPQR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------TCQSK--KFVPTDGR-------GNYRRSKLGQ
RKKRL-AEWRAYQARRMNHSGQKKESAESLSKS-YQSTL-KKGRVPLES--HFRIWIKQL
LQWIF-PNK-SK-RPEEHLQQGKPVA--ATTGYSSHYSSHQ-TQEPLQSR-LI-ME----
GRTAEAQVLMTAVGKILKEKMVFHYRPH--------------ASELHWCQG---ELWAPF
GP--HY-CY--HRFSSYKEKRRVVGGTSCHHQVTPLG-HSCSKNSEWTSARGIKL-----
------------------------AVLPREPGPPLGRG-----CQHRSRVT--SVSS--H
SL--HC--PRHC-LFQK-------------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLFPYFSYLRYDDPP-------
SPS------------------PGKRKCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--RAC
PRG-------LE-ETWDLFS-QLQ------------------------------------
---------SLLGP---HPDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------DSRSS---HETMEDAAP-M-------LSPLASPD PR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPPHTSD-------R--PSPPKAFPA
PPLR--D--------------------------------------------STLIIPSHC
DS-VA--LPLGTVP-----QSLSLRK-----DLAAS--VPAISGLG-GS-NSQVSA----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCKMEAG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NDGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSA QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISC---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPID-----NSGVACPAS-QKKVQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDEL-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDP--CPRLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENVLKAHVGR-KLGQINEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------ACVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CEPGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRQQVLTKASD-MPD----SL
-LASSAACKQFQR-APL-----GIPSWNDHGPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AEPQPRVPLGTHMLANLQA-TSDDVR-
GFEAPGTS-KSS-LLPKMSVSQDPRQRCLMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLVTENLAPQVP-QGHLQSMPAGN
MRAS-QELRDL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--MFPPLHKS-------ENSRKPNLEK
HEERL-EGLRTPQPSP------VRKTEDTRQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKKKSK-----------PAP--VTA---------E-SQKTGKNRSCV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARH--------------ASKVNQHKQ---EFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNRERQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MEKILSAL-----NSLAET
---WLTFG---SASYHIDLNDTLLGGLGL-------LLLYVCYLI-VKLVLQPL------
------------------WRKKYTQKLEPLL-----------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SSRPLGE---L-DDA-FH--------------------SGPRHPDSLFSESPR
SAS-K------VSSL-LSQAT-PEDGT--AAPSC---L---ASTAPV----TE---GSLV
LSPQFTVSQPGRPALAIPPSPSS------L-------S-PFAPLENLLS-PTLLGDF--L
IPEPTPP---LSPEFFLDST-----PPYTLASLTLPT-EEA---QDSEV-VFPPEATRSL
VSRP----------SEVSVNVPITTGT-GDERQPAPD-----------------------
------------------------------------------------------------
---------S-SQPRPAA---DE---LLSS-----DLAHSFNQPLP--DPYA-SQVPLW-
G----GRLESG--N-FLAPDS-DALVRL-KRQD-R------KG-------GDFHTTS-DP
-------------------------------------EN-N--E-----GFIKSPHSLEK
PSSSEPSANPQALPASHL-----------------------------------QVPQSKT
SG-DDAESKPSQLFWGPPS-LHSEALHPTTP-AESDRSP-----TPVYFN----------
----------SMAEASVA-----ITLP----TAPL---------VTESQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TWLQTQSRSH----SQADPRTESQTQPQ--PHTPVLVWTH-SPH--
-SQLK-----VCGVQFHRT-QGA-QPLGPSET----------------------------
--------------------QRLEYNI------LKKEQE---KVWGLPSVVKKSQDTFCP
PPPKPSLVSR-----SFKSQTPRPIL--LGDFPLTKELRKKLEHHLRKRLIQHR-----W
GL-PHRI-NESLSLMYPQSEL-------------------MEPLAS-G--RSCG----LS
W------------------ISLFKYRGSMESYA---TVLSG-SGKSRNSTSESHPL---A
-RTEV--KAQ-TYSQDTG--------QEDHLQN----N-FWEAPR-NSLAS-ALKTDQEH
L--------AGSRSDQLSS-----LSLVSQCQ-KRIEKALEEHFHK-KAQEIRKGQMP-S
TVEKSWRSIN---KPQ--PPPETTPGQL--K-DLAPLAGEE------DALIEYQHGLLLS
QSKEKVLEEHIKTFGRKMTLGLP-QRVEEPLESY--------MTRAEPPHYFSQFHIHPH
TVAG-MEPGQSSRFL--------QRHPSGDGMRTV----N-----AVPTRGS--------
----------------------------------------------------------CL
SAS-SPVGNIEPASEHK-----------KGVVDK-HLSTAQSDREPI--QSWIPSTVDKS
SLQQ---SGS--NRQSPELP----VRPD----GPTDETLASSTETRGPQGQRRSWR---D
GSMTEGT-----------T----ELLKGQKRPGLHPQSPKILTVPQDTCSPG-S------
-----HGN-PCQ-AMQGISVPHNPETFDPKSRVSRGVVLPSERGLHIQATGVPH------
----------------------------------VSSA-SEEMT------SKCQGPSGGD
KTAS-QVLRVY---LPTVGVS--MEP-GQGPWFPPR--SSS-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCRSQ--AC-SPAAKG------VSPPAAKSGK
FDGGD-ASLGSSQTRGKRHSIQARAPKETHGHTSSLA-LSPK-GQPPEN--QFTNQVKCF
WQWMS-PGRKHK-GQEKSLAKGNSSS--PSG---------KG-KSLVKERCEF-------
FGNIEAQSCVRDPGVILRKQLGHRHGTVI-PCPQATGP-SLKGSEET-----RQAQAGPV
KRH-HS-R---SQAAHSQ----VQRVGSCSPERGQTT-LKR-----YGIAGKAEVVETSS
ILP---------------------PKSTL-------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPSLL-----ESIYTT
---WLSLS---STIWAMDMILAFVCGLGL-------YLLLLPFLE-SHLSSSPS------
------------------DINFT-RKPQIQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-QYMKKF---RN----------------------------------HCR-
NDAKAW------------------------------------E-------ECLKKLK-E-
KE--KDELFLEEMS-----------------PGHH-LNS-L--G-----NMFNSASAKQD
STTL-------SPFWNLKEK----------------------SE---EQMATQKLSYPKI
SG-DHLQEKYDQLYWGLPS-LHSESLVAAAW-IPQTTSTL--PSPFFLFNVISS------
----------VYPIHLQDKMSPVLPHT----HPLS---------YLDLQ-PPPLILSPL-
-EFQSP-ALNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VHFQSPLP-----VLLPSSL-PYS--
----R-----DSGACYSQS-QSKPHC-PTTEI----------------------------
--------------------QYRERPL------VTKQLE---SRLTLPLMVQK--DAYSI
LASNPSHD-W-----A------VPIF--PDNFPISCELRDKLEQHIQKWFIQHQ-----W
YF-PPEIQ-ESEEVMGLQNSV-------------------TGNYQI-R--DQPC-----T
S-Q----------------AHMSTGEHNKQGQK---VKF---------------QL---E
--NES--CKNLGPILGKG--------PK-DPVK----GL-EKNVV-KVQGA-NILEP---
------ERNLVKHFKSDSRND----SSNYI-D-EDLENNWKANFGT-KSGQINQGLTP-L
SMRQSWLAMN---DSF--CDT---DIHMETR-NLTAIKSSE------KFMCSREKLAFLN
PETRQTLEEHVVRFWVKHRWGLP-LKMLKPINLF--------KLKSTESLPLTLCTQPSS
TNS---VHRTNSAVEV--------------------------------------------
----------------------------VRFLGKP---CLRQII-IKDSS--P-PPGNLL
-LVSSPSCKRA---AIR-----RPPSGVDHEPSV-ALPNKPQSAYLA--ETLAYNFMETP
TQSG---G----------------------------------------------------
------V-----------------------------------------------------
LKDEMETE-EVL-LLPRMTCAPNLRAHNPQAKVVSEYPYNVETELTGQPQIYTTSV----
--------------LLPK-------------HSRSMPLPVDTLTSNALG----------D
---------IV---MVDGGNG--LVQ-Q-RPSTPKHQVSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGQIK--MLVPTYQG-------EDTKRQSERK
YEDMS-KF------------SPVTERKNNFENQYYQTLP-KTTQVLPES--LFQRLLSRF
LPRVH-PKKTIK-GQECHPQKDNPTA--ATA---------QNQRRQVRKQPYM--D----
DNVTEAQKLMTTVGQMLEKKMM-QHQHH--------------ASKVNQPRV---VPPGPT
SW--FS-HG--HMPVSCLKRRRPPSYP-----ANSLC-QRRYIQGRHNRGQLPQKS--VQ
FSQKPQILR-NPRHMYPK-----------SALN-VVNS-----SQNRTTVP--RTPN--Q
H--LCC--PRHCAFQRN-VCR-ELGHPSVAFPNRKT------------------------
-

-----------------------------------------MENILCFL-----SSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYMV-LTLYLSPT------
------------------EKNNDIQKHQGRARRR---RKSV-------------------
----------------------------------------------TF----KDR--KNF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCGPLGQ---HHDTT-CF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----C---VSPLPSG ASV----TE---SSFT
LSSTPSATPTEDLILSPRPKLSP------PPLLILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GETSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPHAK---GSF---SS-----NFVPSDFMKELL--TLHS-SEASLA-
GHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KSGSFPTQLR-----------------QNYQ-LNS-S--R-----KMLASIADKHD
MVEF-------FPFGANKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIF----HKFPVLPSP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSQAQHQ-----SPLPVLLPSPP--
-FLIR-----ICGVCFHRP-QNEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALVRK-----SFKVHVPVSII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------HSSVEGQSLNVLKK---FGSII-PRTLHERSSNMLSL----
--ENV--GNYQGCSQENG--------PKNHLLQ----DP-ETSSD-EDLRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTAHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSED------HGVDTSQEISFLG
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MKKVLSILNSSILTSAKES
---WLSIG---SIFVDIYPKCIILSVLGL-------LFLFLRYLI-LKPFLP-T------
------------------QTSQGVRKQQGRA--KRERR----------------------
---------------------------------------------ASF----NEF--RNF
---HG--E--AR-ERRKL------------------------------------------
----QAVVQSPCGQ---LYDPF-YF--------------------RQALCQDPRCDVCNG
ATV-K------VRRL-LSWAS-LEDCS--ASASS---MASMA STASV----TE---ASFT
LSSSLSPSPSGYQLSSFSVAPSP------PPPSILSTS-TFTPLEDTLL-GTPQGDS--L
PPEPTLT----STGFPLDHL-----LPHPLPKSPSVAHPAA---QQTEGPLRPED-ILSL
AGSH----------GDQFLHATTTCDA-LP------V-----------------------
------------------------------------------------------------
---------S-YQQQPGA---QS---SSPS-----QLKCLVNQEIP--NHCS--SEDFWR
GQASPHFTVPQ-----------KVLKIL-ERQE-E------SQ-------ADVLTLK-DR
EG--EAEP----------------------------------------------TAE-QN
LGAS-------FPLGGSRVI----------------------LS---ELNPQ QGLAQVQS
SG-GQLEAMPMQHFWGLPY-LHSESMSCITT-LSSHCSS-----MCIWFN----------
----------------RTTDSPALAPP----SPLP---------LPERQ-SQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------TLTQSQ----YQSIQLATPHSQLQ-----T-LPGPSPSSQ--
-SQVR-----VCGVYFRRS-Q-EAKALLQSEI----------------------------
--------------------HHLEYNM------MAKDPE---REWALPSVVQKPQEELSL
LPSKLSLAIK-----SSKLQTPRSVP--PRDFPLADGFQKMFEQHLRKRLILQR-----W
GL-PQGI-YKSQLWANPDPS-----------------------EAS-K--SSSG----LS
G---------------------FKHKDNKAWPN---TVSNQ-SGSPQEK---SVSV---E
-RKTV--KAH-EQTLEII--------QK-YICS----NS-KTALD-NSLPS-DHE-NLQG
H--------SGSLSDQSSE-----TSQVSQCR-KKFETPPKEHLKS-HIDGTNEDQVP-V
TLSRLKHRPL----------HFKPC------------VGKE------EKKAE-----RQS
PSDI--KDEDTKSVH---------------------------------------------
---------------------------------RI----T-----VPGVQQT--------
------------------------------------------------------------
-----------------------------------------------------SVVLDTT
ILKE---S-E-AKKPSPDVP----KMLAKAGPMPVGKSLSSSKIVQGPQGTKMDDK---H
VFVSNKV-----------S----NIVK-EQLGGLQPRPTKISKASQCKSAKD-GDGNTP-
STQR-TQL-AGR-APEGISGPPDIQASDFSCQVTREEKSESENRQPIQASEPPK------
----------------------------------VMLPVSDKLTHTP-LPIHDQMPSSAL
TNAV-QVQ-------------------PQEPEMPAH--SLG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGLNK--DS-PQSAKR------S----WKIE-
---GV-AGPETLQPSGKIHRAQDSPTPGNHGKRPIPPSPPVKALSPPEH--HFRKQVKHF
FQWLS-PDRKCK-GQEALLKRGTSPP--SPA---------HD-PE-QKGRATF-------
PGNTVAQKALRDFGKVPKEQPGHRHGAADTMRPRVPVSPPTKPV-KTKPKREYCVPTDPV
QGR-QL-H---PPAPVSK----VPSPRFHNQAAAFVD-QKR-----CVAERARQPQKCEA
LQP-------R------------PSASHRESELRQ-NLLWSRAGKVPQGTP-PFAVG--T
MLADMSRLCEQKILAQN--FRG------KAFVPQK-------------------------
-

-----------------------------------------MENIPFPL-----KFLSDS
---WINTP--SSTPWVLDIFLTLVFAGGF-------FFLLLPYLSCFLCDPPSPSP----
---------------------GKKRMCRGQRRGRPKGR------KKN-------------
---------------------------------------------NSL----KAS--RDR
LTG-------LE-GTPDLFS-QLQ------------------------------------
---------RILGP---HPKKGKDF--------------------GQLSGPDPPDEECKR
GPD-G------ASQSPQEPQEPMEDTAP-V-------LTPLASLD PQ----TQ-------
--------------------------HPSPLGSTPSPS-PMATSV------SPLSAS--Q
PPEPS---------LPLEHP-----SPEPLAVFPNPPHTPD---PLACS--LPPPKGVIA
PPLR--D--------------------------------------------STLMTPSHC
DS-VA--LPLGTIH-----ESSSPCE-----DLATS--GPGISGLG-DS-SSHVSV----
--------SAFWCQETTR---TWC-----------IFNSSVQQDHL--SCYP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GMQV-T------ER-------ARINIWE-E-
EE--KDGSFPKQMN-----------------TEKH-LNS-L--G-----NLVKSLDAEQD
TTTL-------KPVWNTE-D----------------------LK---QSSSP QKLSDPRI
LK-EHFQKNYSQLFWGLPS-LHSESLVANAW-VSERSCTL--QSPPFLFNGIPN------
----------VRPVQTETTMSPLLFQA----QHLS---------HLRPE-SQPFISP---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFQ----LSPMAQAEAQARLQ-----SSFPVQSPAFA--
-SSIN-----NSGVACPAS-QNKAQALTLPEM----------------------------
--------------------QCPEWS--------SKQLE---GGLALPSRAQKPQDVFSV
STPNLPQDSL------------TAIV--PESFPVSPELRRQLEQHIQKWLIQH------R
SN-LGMT-QESPDLMQPQEKL-------------------PGTSQA-G--GKLR-----P
L-Q----------------SSMSTGESSKDIQK---VM---------------FQ-----
LERNP--CTPLG----QT---------PQNLAR----CM-ESFPG-NILGA-ASE-ELER
DLK--------MSLRKDSESD----LLRRTER-NCIKNILKAHVGM-KLGQINEGLIP-I
CVRRSWLAVN---QGF-----SMSNTHMNTS-NLAPLKSGR------ASVNTSQELSFLH
PCTQQVLGHHIVRFWAKHKWSLP-LRVLKPIKLF--------KLEKVSSLSLTQLAGRSS
ATY---ESKSSSKVEK--------------------------------------------
----------------------------AVFLRESPPADLRKQVLTKASIQTPD----SL
-LVSSPTFTQFQM-APQ-----GIPSWNPHGPLK-PPPAGQEGRWPS--KPLTCSLTGSA
QQSG---SL---------------------------------------------------
--------GAQSSR----TGETME---------AAPQPSVPLGTFLLANLQG-TRKDVS-
GLEAPGTS-KGS-QLPGMSVSHDPEELYLMGEVVSEFEPRMATKSETQSQVCGAVVLLPD
GF------------------------------TD-IPLATESLASQVP-HGCLQSMPTGN
MRAS-QELRDL---MEARRSN--LGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPKCQGLC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQNQ--MFTPTHKS-------ENPVKPNFEK
REERL-EELRTPQRTP------VMKTEETRQDEGLQLLP-SKKQPPSIS--NFGKDIKQF
FQRVF-SVKKSN-----------PAP--VTA---------K-SQKIVKNKSHA--Y----
SSCAEAEGLMTAVGQMLEEKMTLCREHH--------------ALKVNQHKQ---EFQAPV
CGLPCS-----HRHLFHPEHSRTLGYAASSQQATLKS-QSYPNRERHIRDQQ--PLKSVR
CNNEQWGRR-HLH-----------PLLPKKAVS-PVSA-----PQGGLKTP--GAFG---
-HHPHC--PKHCLLWEG-I-----------------------------------------
-

------------------------------------------------------------
-----------------KIFSNLLFLFLY-------FFLSFFFVFFLRWTGPS-------
SSPFLVSQRHLVSPCHLVSPRHRVSQCPVGWRGRPRHR------MKN-------------
---------------------------------------------NSL----RAC--REC
PRG-------LE-ETWDLLS-QLQ------------------------------------
---------SLLGP---HLEKG-DC--------------------NWLSGPDPPGEVGKR
APD-G------ASWSS---HEPMEDAAP-M-------LSPLASPD PR----TK-------
--------------------------HPEDLASTPPPG-QMTTSV------SSLSAS--Q
PPEPS---------LLLECP-----SPEPPALFPHPPHTPD---PLACS--PPPPNGFTA
PRLR--D--------------------------------------------ST-LTPFHC
DS-GA--LPLGTVP-----QSLSPSE-----DLAAS--VPAIAGLG-GS-NSQASA----
--------FS-WWQKTTR---ISC-----------VCNSSVHK NHL--SC----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QREITMSPLLFLD----QPLS---------HVGPE-PQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPTAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIK-----NTGVACPAS-RNKVQALSLPET----------------------------
--------------------QHPERPL------LRKQLE---GGLALPSSVQKSQDIFSV
STPNLPQERL------------TSIL--PENFPVSPELRRQPEQH--------------M
GQ-RGRI-QESLDLMQLRDEP-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSTSTGERSKEEQK---VK---------------LQ-----
LERDP--CPHLGQILGET---------PQNLSR----GM-ESFPG-KVLGV-TSE-ESQR
NLR--------KPLRSDSGSD----LLRHTER-HHIQHLLKAHMRR-KLSQTNEGLIP-V
RVRRSWLAVN---QAF-----PMSSTHVKTS-NLAAPESGK------ACVNTAQELSFHE
PCTQQVLGAHIARLWAKYKWGLP-LRVLKPIQCF--------KLGKVSSLSPVQLASPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------DTFLGKPPMASLRKQVLTKASVHMPE----SL
-QASSPACKQFQR-APR-----GIPSWKGHGPLK-APPAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRQ---------AVPQPRVPLATCMLANLQA-TSEDVR-
GFKAPGTS-KSS-LLPRMSVSQDPRKLCLREEVVSEFEPGMATTSETQPQVSATVALLPA
GQ------------------------------ASVLPHASENLASQVP-QGHLQSMRTGN
MRAS-QELCDL---MAARRSN--LGH-K-VP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNRQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPTHKR-------ENSRKTSLKN
DEEML-QGLRTPHLTP------GRKTEDTRKNEGVQLLP-SKKQPPSIS--HFGENIKQF
FQSIF-SKKKRK-----------PAP--VTA---------E-SQKTVKTRPCM--H----
SSSAEAQQLMTAVGQILEKKMSLCHRRH--------------ASNGNQHQQ---QF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPSIL-----ESIYTT
---WLSLN---STMWAMDVILAFVCGLGL-------YILLLPFLE-SHLSSPLP------
------------------NMKFT-RRPQLQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------C----------------------------------------
--------QS-RCRKKF---RT----------------------------------FFW-
KDPK-----------------------------------------------GLKKLK-E-
KG--KDGLFLEEIS-----------------PGHH-LNS-L--G-----NMSRSLSTKQD
STTL-------PPFWNLEEK----------------------SE---QQMATQKLSYPKI
LG-DHFQQKYKQLFWGLPS-LHSESLVAAAW-ISQTSSTL--PSPFFLFNVISS------
----------VYPIQMQDKMSSVLSHT----HPLS---------YLDLQ-SPPLILSPP-
-QFQPP-VLNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VHLQSPLP-----ALLPSPL-PYT--
----R-----DYGTSCSQS-QSKPQC-LPTEA----------------------------
--------------------QYRERPS------LAKQPE---SRLAFPLMDQRPQKVYDV
LAPDLSQD-L-----A------VSIL--PDNFPISSELREKLEQHIQKWLIQHR-----W
DL-PRKIQ-ESLDVMQFQNIV-------------------TATCQT-R--DKPG-----C
S-Q----------------PFVSVGEHSKDGQK---VRF---------------QL---E
--KES--GKNLGPILGKI--------SK-DPIR----YL-EKPP----------------
----------------------------------NLENTLKSHLGT-KSGQINQGLIP-L
SVRRSWLAMN---KA--------------------SSKSSE------KSVSSSQKLAFLD
PDTRQSLEAHVVRFWVKHRWSLP-LKILKPIHLF--------KLKSVESLPIAVCAPPLE
NTP---VSGTSSSIEV--------------------------------------------
----------------------------VGFLEKPSQTCFREVI-IKDSS----SLGNLL
-LVS-SSCKDIEK-ALG-----VLPCDVDHESSK-ALPTKPESRHHS--EILTHNLMDTL
SQSG---T----------------------------------------------------
------V-----------------------------------------------------
LEKEKEMK-EVL-LLSKRTS-----PHSHQAKVVSESPNNVKTESAGQSQVYTTSV----
--------------FLPE-------------HSRSMLLTKDTLASQVLG----------D
---------IV---VVGGDNS--LVQ-Q-KPSTPKHQLSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KEQIK--VLAPTYQG-------EDTKNQSKGK
HEEKL-KF------------TRVKEKEEIFRSKHYQPPP-KPTLVPPES--PFQKLLSRF
FRWIQ-LKRTIK-EQKSPPKKGKPTT--TAQ----------SQPKQ-VKKKHV--D----
SNVAEAQELMAAVGEILEKKMMLQRTLR--------------DSKFNQQRE---TRPPHA
PQ--SS-YG--HQPASNTEQRRTPSHP-----ASSSC-KKCSIQDRH-RDQPSQKI--VR
FSNEPQT------------PQDPSLLSSNTPSN-LVCS-----SYYGRVVL--GVSG--H
Q--LHC--PRHCALRRS-VCS-QL------------------------------------
-

-----------------------------------------MENIRCFL-----NSYTET
---GLSPD---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPS------
------------------EKNNDIQKHQGRVRRR---RKSV-------------------
----------------------------------------------TF----KDR--KSF
QRE-------AE-EEKKLLS-ILK------------------------------------
RFG-PPVSCSLLGQ---HHDTT-RF--------------------RRLLCPDPVCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSPLTSG DSV----TE---SSFT
LSSTPSATPTEDPILSPRPKLSP------PPQLILSPD-LITSLADLFS-PLSLRDP--P
PPQPVSP---LDSKFPVDHS-----SPLWLPFP-LLPPPHI---QRVEP-SL-PEANFCL
NTTFSLDSTQCQD------ISQVMNPTDSCAHHHKPPIP-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---GSF---SS-----NFVPSDFIEELL--TLHS-SEASLG-
RHSVANLIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPIQLR-----------------QNYQ-LNS-S--R-----KMLASIADKHD
MAES-------FPFRASKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPNVL-VQRGHSS-----MFVFFNGITN------
----------TSIF----QKSPVLPPP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLTQGQ----SPHLTEVQSQAQHQ-----SPLPALLPSPP--
-FLIK-----ICGVCFHRP-QNEAQSLTPSEI----------------------------
--------------------NHLECNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNLTLVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIQG----PL
H------------------SSSVEGQSLNVPKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNFQGYRQETG--------PKNYLLH----DP-ETSSD-ENPRS-NSERDLNT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHQ-NTAALVSDD------HCVETSQEISFLS
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKCPVGRRRRPRGR------MKN-------------
---------------------------------------------HSL----RAG--REC
RRG-------LE-ETSDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--LPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--FPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-RWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-LFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNRMT-----------------PEKH-LNS-L--R-----NLAKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
WQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIQ-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRRQLE---GRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGEGSKEAQK---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ELER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
CVRRSWLAVN---QAL-----PVSNTHVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQGLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPAWKQFQR-APR-----GIPSWNDHEPLK-PPPAGQEGRWPS--KPLTYSLTGSI
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVNEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLVSQVP-QGHLQSMPTGN
MRAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSVS--PFGENIKQI
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSRV--Y----
SSSAEAQGLMTAVGQMLDEKMSLCHARH--------------ASKVNQHKQ---KFQAPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

--------------------------MPRDQLLEGS-IPIQMENIPFPL-----KFLSDS
---WINTP--SSTPWVLDLFLTLVFAVGF-------FFLLLPYLSYFLCDPPSPSP----
---------------------GKKRMCRGQRRGRPKGR------KKN-------------
---------------------------------------------SSR----KAS--RDR
LTG-------LK-GTPDLFS-QLQ------------------------------------
---------RILGP---HPKKGKDF--------------------GQLSGPDPPDEECKR
APD-G------ASQSP---QEPMEDTAP-V-------LSPLTSPD PH----TQ-------
--------------------------HPSPLDSIPSPS-PMATSV------SPLSAS--Q
PPEPS---------LPLEHP-----SPEPLALFPNPPHTPD---PLACS--PPPPKGVIA
PPLR--D--------------------------------------------STLTTPSHC
DS-VV--LPLGTIH-----QSSSPCE-----DLATS--GPALSGLG-GS-SSHVSV----
--------SAFWCQETTR---TWC-----------IFNSSVQQDHL--SCHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GIQV-T------QR-------ARINIWE-E-
KE--KGGSFPKQMN-----------------TEKH-SNS-L--G-----NLVESLDAEQD
TTTL-------KPVWNME-D----------------------LK---QSSSP QKLSDPRI
LK-EHFQKNYSQLFWGLPS-LHSESLVANAW-VSERSYTF--QSPPFLFNGIPN------
----------VRPVQTETAMSPLLFQA----QRLS---------HLRPE-SQPFISP---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFQ----LSPMAQAEAQARLQ-----SSFPVQSSAFA--
-SSIN-----NSGVACPAS-QNKAQALTLPEM----------------------------
--------------------QRPEWS--------SKQLE---GELALPSRVQKPQDVFSA
STPNPPQDSL------------TAIV--PENFPVSPELRRQLEQHIQKWLIQH------Q
SN-LGTT-QEAPDLMQPREKS-------------------PGTSQA-R--GKLR-----P
L-Q----------------SSMCTGESGKDIQK---VT---------------FQ-----
LERNP--CTPLGQILGQT---------PQNLAR----CM-ESFPG-KVLGA-ASE-ELER
DLK--------MPSRRHSESD----LLRRTER-NRIENILKAHVGM-KLGQINEGLIP-I
CVRRSWLAVN---EGF-----SVSNTHMKTS-NLAPLKSGR------ASVNTSRELSFLD
PCTQQVLGHHIVRFWAKHKWSLP-LRVLKPIKLF--------KLEKVSSLSLTQLAGPSS
ATY---ESKLSSKVEK--------------------------------------------
----------------------------AVFLRESPPAGLRKQVLTKASVQTPD----SI
-LVSSPTFTQFQT-APQ-----RIPSWNPHGPLK-PPPAGQEGRWPS--KPL----TGSA
QQSG---SL---------------------------------------------------
--------GAQSPR----TGETME---------AAPQAGVPLGAFMLANLQA-TRKDVS-
GLEAPGTS-KGS-QLPRMSVAHDAEELYLTGEVVTDFEPRMATKSETQPQVGGATVLLPD
GF------------------------------TD-IPLATETLASQVP-HGHLQSMTTRN
MQAS-QELRDL---MAARRSN--LGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNLKCHSSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------Q--NQ--MFTLTHKS-------ENPMKPNLEK
REERL-EELRTPQFTP------VKKTEETRQNEGLQLLP-SKKQPPSIS--NFGKNIKQF
FQQVF-SVKKSK-----------PAP--VTA---------K-SQKIVKNKSRA--Y----
GSCAEADGLMTAVGQMLEEKMTLCREHH--------------ASKVNQHKQ---EFQAPV
CGLPCN-----HRHPFHPEHSTMLGYAASSQKATLKS-HSHPNRERHIRDQQ--PLKSVQ
CNNEQRGRR-HPQ-----------LLLPKKAVS-PVGA-----PQSGLKTP--GAFT---
-HHPHC--PRHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDLNFICLSGLGL-------FILYLFYMV-LTLYSSPT------
------------------EKNNDTQKHQGRARRKRKS-----------------------
------------------------------------------------VTF-KDR--KSL
QKE-------AE-EERKLHS-FLK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLASSA SG----AE---SSFT
LASTPSATTPEDLILSSRPKPSP------PPPLILSPD-LITTLADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIDHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCARHHGPPTP-SALPP-ED----C--TVTQS
KSN-------LTVLKTFP-EMLSLGGS---GGSSTS--APTTKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANIIQPV--N-ISFLSH-DIPALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----NMLTSTAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVF-VQHGRSS-----MFVFFNGITN------
----------TSMS----HESPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SLHLTQVKSLAQPQ-----SPFPALPPSPL--
-FLIR-----VCGVCFHRP-QNEARSLMPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPVLVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQNKI-------------------SELSVS-E--SIHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--GNYQGCSQETA--------PKNHLLH----DP-ETSSE-EDLRS-NSERDLGT
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--CLPEKSHSQIKHR-NLAALVSED------HRVDTSQEMSFLS
SNKQKMLEAHIKSFHMKPILNLS-I-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNR--KCF
QRE-------VE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---RHDTT-RF--------------------HRLLCPDPVCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PQ-LILSPD-LITSLSDLFS-PSSLRDH--L
PPQPVSP---LDSKFPVDHS-----PPLQLPFP-LLPPCHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APTIKGIN-HS-CLASSE----
--------FS-WWHPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SQASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KSRSFPTQLR-----------------PNYQ-LNS-S--Q-----KMLSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QEPPYSKC
FE-DHFEQKYVQLFWGLPS-LHSESLHPTVL-VKHGRSS-----MFVFFNGITN------
----------TSIS----QESQVLPPP----QPLS---------LPSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPALLPGPL--
-FQIR-----ICGVCFHRP-QNEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALARK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------SSSVESQSLNVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DK-ETSSD-EDPRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEESHSQIKHH-NLAALVSED------HCVDTSQEISFLS
PNKQKMLEAHIKSFHMRMLWGLP-RKILESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISWGDSKVGVSKFRRRS--SFQGEKLGTT---------SSVPVLDGPHPVTSPV
GKEGQDTLRRQYSDTDHDFIESDSKDGASTLLRRGTEDFQGEILESTNSL--P-ILGHSP
-LVTSPVDQEKQG-TLG-----REFADTDNDLTE-NVPTTEDGGQTF--LPPAHSIIDEV
SQKQ---TVP-ASRSSAEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRKT------
FPE---------------------------TCALQSQNRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLNQLK--LVQRKDSQPQSHFT------
----------------------------------DTSIALENLTSKDL-LTHPQGISSGD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAIKR-------VSPRRPKGGE
LGGGD-AGLETSQLRRKSHAIHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSITDE-EQEISRAKGSSLS--SSV---------QN-RGRVIRRAAF-------
IGTTEAQKIRKDTRDSPEEKLGHKRGIDV-TCPQEPVSFPVEL-GKAQHNPELQVRAEPV
LGYPCN-----YMAPSCK----LTCTKSCSKQAIFVG-QNYPTRIRQNTDKDRQPEKVEA
FKGKLLCQR-HPQ-----------SV-----------------SLVCPAVS-TSAKS--T
VFSDVPLLTGQKMLLKH--FQG------GKFPPTK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KK-------MSPQTLE-EV
KK--RDDISPDPKR-----------------SEGK-LTA-L--W-----NSQGSTVTNLD
TQVP-------KINLKLKGK----------------------RK---YFGAYDQVLYVKI
PE-GDLGQKHSQLFWGLPS-LHSESIMATLL-VPASSYSP--EPCLVLFNGVCK------
----------TASAPVLSHGLPALPQP-----------------LTLVH-PQPLPKVA--
P--QPQ-TLTEG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MPQ----VHMQ-----SPLSSMA-LPS--
-LPCG--------SALQIP-QTRTVSDVLNGK----------------------------
--------------------GHLQYHL------VQNPQD---SLWGLVPECQQYETALGL
PVHSFPVGSQ-----SSQTYVSVP-G--SGLFHFSSEHQNNLDPYGPNNLTSPS-----C
FEL-CNR-PGVPEVMNTQFNP-------------------TGVSSY-C--YKYA-----T
S-Q----------------CCVHWGNICADPGN---GELSH-SESYCVKVPMKPQL---R
--KDA--AKNLGQILGKC--------PLDNTQM----IS-GCCIL-NGLKT-IPET--EG
ESV--------CHSRTSLENEQLTISKKNLDQ-RHMRSILRLHMSR-KCWQITMGRIP-I
VVCCSWLDED---ASL--WRSPL---------------GKI------HCDTAIPEIPFLD
HKTQKMLEAHLIRFRVSQQWGLP-IKVIESIKFY--------ILREAKTWPLPQSDLPLS
LNS---IPGLDLKSNF--------------------------------------------
----------------------------PSPLRGSSDLLHGDKIETTDSA--PTT--DYS
-LTLLHVDSEGER-SLR-----QSVSSPTSDVSE----TVEDDRP---------SN-PDL
SQNE---TDLQSRPRQ--E-Q--PVKEDVTLSDSENESASSASHLVTAESRQSVE-----
-----KNPKY-TVT----PNMLREMILKARELFVRSGSDSIIKSKSSTKKDE-D----E-
SLSSPLVA-TGQ-SPSKMSVPEEPTAPDL----FKELRSKLEDQPQSQSEAWED------
----------------------------------ESSFVSDSF---SL-PSSSNSVSSAD
VSVF-WDTQGH---MYSTGIS--VDP-WQEPSV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRFLK--NVMPAQKR-------LSLPKSRKEN
GRSDP-QELETPKAGKKSQPSKEKS-------------S-K-REHPPDS--YFRKKIGQF
FQWLY-SSKDSP-R-----------------------------HRSEKDGALF-MS----
CGPPEAHELMASLGKLLEDKLLYGQNSE--------------FLEWSQTSML-AQ--PAL
KG--QP-SD--LGA-ADGHHGEEASNCSCPQTAITPG-PSHML-SLGQRHHPLP-FEYP-
PSAPESLSS-VQA-----------PLA---------------------------------
------------------------------------------------------------
-

-------------------------------------MEFRKWKVLSFL-----NSHTDP
---CLSFG---STSLDIDPNLTVVCGLGL-------LLLFLWYLV-GFPCLPTS------
------------------CKTKDIRKRQGRAKRR---RKGG-------------------
----------------------------------------------TSK----GW--RCR
QTE-------TE-EKMKLIS-ILK------------------------------------
---------SPLGR---HDDTT-RF--------------------RQLLCPDPSCEVCNN
ASA-E------VSWL-LFPEA-LEDATS-----S---VSPLASTA PV----TD---SSFT
LSPDASAVPPGDLIPASLSEPSP------LPPSILSPR-PMTPLVDFFL-PSPLGHS--L
SPEPFAP---LDSEFPVDCS-----PPQALAFP-PLLPHDT---QTADP-VVPPEATLSL
NTIFSLDPTFAQDINNLSDLSQAMNPIDSFACHHAPPTL-CVSPQ-QD----CTLTVTQS
KSI-------AILLKPLP-ESTPPDSP---GALSTY--VPTLRGID-HS-GLSVSD----
--------FS-WWKAHAK---DLF---PP-----TLTQCDFNQEFL--ALHS-AETSFG-
GDPAAIFVEPG--N-LSFLSP-DVLALL-ERQV-Q------KR-------SDFLMWK-EK
EK--KKDYFPKQFG-----------------PDYQ-LNS-S--E-----KMMESNADKRD
PAAS-------LPFWSSKDK----------------------PK---ELHMH QQPPYPKS
LE-DHLQQKCIQLFWGLPS-LHSESLPSAFH-VSGDGSS-----VFI-FNRNSN------
----------FSAD----QESPVHPHP----LPLS---------LPEIQ-PE--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPPSQ----PLPLTEVQPQVHPQ-----SPLPVIPSSPL--
-SQIR-----ICGVCFHKP-QNEPECLTSSEI----------------------------
--------------------QQLEWNM------LQKQQE---NLWGVPSVVQRSKEDSCL
PAPSISYHQVPRGPGAPRAHASISIP--PGEFPLSDEIRKKLEHHLRKRLIQHR-----W
GL-PRRI-TESVSLLMPPREF-------------------LEISEA-E--SNYG----VS
L------------------ISVLKGQSSKNL-S---VGLSQ-PGSIHERDSEML-----Q
QEADV--GKDQGQSLEHH--------PKDHLLN----DT-KSSSD-KDLEY-DSEKDLNS
Q--------MPSLSEENLR-----VSAGSLGQ-RQLENALKVHLSK-KFEEINEGKLP-G
TVNSSWHAIK---QTL--LILEKSHTQIEER-NLPSSMGES------YSLNTCHELTFVD
SRAQQMLEAHIKKFHMRMLWGLP-RKVLESIEIF--------KLKDASSQSLSHSNFSSS
TNE---LSEADSKSGSIRFQRGSSKSLHGDKVGTT---------ASA-------P-----
------------------------------------------------------------
--ATRPVGKGGQR-ILR-----RSHPNTNRGLAE-DVQRSKDARQTR--PTSKLCISGKA
NQRQ---MHP-ANRYPSKL-L---TKQAGARQEPKSKSVSSRDKGEMKQGQKVEK--LEP
VSM---------------PNVSREIFRAEELNAVQLKASENLTTSKPGSSQA-INVNEN-
KVETTVTT--E-RPPRKLPVPQDPKSLDLKEQLLDELKCKLENRGHSQAQGRPL------
----------------------------------DASLAPDNLTYKAS-LTHAQGVSGGD
MGAS-QVLHAH---LEDRGIR--MEQ-QQKTWVPKNG--FR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------RCQDN--NFPCTAKR-------VSSPGPKAEE
LGGGD-AGLGTSQLRRKSLPTQKMVLEETLGSKSCQTLS-QKGQPPPES--LTRKRMKHF
FQWLY-PGGKCK-RQEGPQEKGSPV---SAA---------QI-RGLVKSRATV-------
TGTTEAQKIMTDIGKFLEEKLVCQHPVDV-PCSQESLPSPEKS-GKTQQKAEVQVQTGPG
QGHPLN-----YRVPVSK----VTNNKSCHQEAIFPG-QSYPPSTRKIRDKNINPHRVVA
CKGQQLCQK-HPP-----------PVPCREHVPHPSPTCRHQAVQAPLATL-STAKG--T
VFRDLSLLFRQKSLLQS--FQG------GKGPIQK-------------------------
-

-----------------------------------------MEKMLFPL-----KSPSAT
---WLSPS---STPWVMDFILIGVCALGL-------LFLLFPYLP-SDP----P------
------------------WRRRSSGEDQRKRRGRSRSR------KQIP------------
----------------------------------------------AL----KAC--RIL
LRQ-------LE-ETRDLSC-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HPPLGGDPLGDVCKP
APA-Q------APQQHG--KR-MQDPPP-ASL------S------PP----A--------
--------------------------SPA PLASTLSPG-P----EPLGS-HSTLSAT--R
PPEPL---------SPLKRP-----APRPHALVPPSPQPHG---PAAS---S--------
PAPR-----------------------------------------------ASSLAGLSC
GP-G---------P-----HSSPPQQ----QQPPAP--TTVISGLG-RS-GEPTGD----
--------LS-WWKEVVT---TW---GLST-----CSHGKFQQQHL--PDHT-PEASFW-
GDRTPRQMEAG--E-YTFIHP-DVQKLL-ETLI-T------KK-------AVMKLRQ-E-
KE--GKGADC---------------------------------------LRVTPLQKEWD
ATTP-------DSFWNQTAQ----------------------PQ---QPPSP QQVSDATA
MG-DHFQQKCSQLLWDLPS-FNSESLVAAAW-VSKASS---GNRHRVSFCEAAT------
----------SLPREPEVEASSQIPQA----PPQP---------HHVAQ-PQLVTPARPQ
PQPQPP-PLAGIQTQ-AHF-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PRVPSLPFSSP--
-PHIR-----GCGASCLTS-QQRAHSAIPTGK----------------------------
--------------------GYLEWPL------QKR-PK---WKRVLPSLLQKSQAVLSE
PTAHLLQERP-----APYSAKSAPIL--SG-AASSPELPEHQWR-GKGAI-HQEQP---R
GS-PGRF-QPPGDPLRPQGEF-------------------PGMPQH-Q--AEDMQGTHLP
S-Q----------------PSEFSGKHSEDGQK---TGFRS-SGR---------------
--------FSGKGCLRSK---------QEPDPSQDRGGS-GRTSV-KLLE--EDKQEAEG
DFR--------RPWKNQSVSS----APGHPDK-KHPENKLQVHLGR-KVGEIKDGWIP-M
PVRRSRLMAK---RAV--P---KSDTCQDPG-KLAS---RR---GGEAHVNTSQELSFLH
PCTQQMLEAHLLRFCVRHRWGPD-LRSLEPINVW---------SCEAQLPPPPHSTCPPL
ASY---ESQVESVAEV--------------------------------------------
----------------------------ATFLGKSLQNGPGDSWTTSKSF--P-TVSGPL
-PPPPPEQEEVQR-APR-----GSQSADTHGRSE-VPPTGQEDRG-S--QPLTCSPGGRT
WHRE---MVP--GSRETILEA--SLTPAMTENEPWPESESTSLGDPCSSRA-LQE-----
-----LKVGSPWAS----AEDALEPLEVGEEK--PPTWEVTLEASMKANSGS-IQVDLR-
RSGALGTT-SNP-SVSTACVAENPGQLCLRAQVVSEIELIVQVDPEEQVPGHASGILL--
----------------QDGATGLC----LPGRHVYMLPAADMPPAQ-APLSTSQSVSSKN
TTAS-QGPRDL---LWKGGKG--PGQ-Q-EPGSPKAKALQKS--QKVLGSADKGKA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HRRPRPGE
PGHGT-KRPRTSEASGRSHPAHAREIGDKQERKYIHPQL-EKGQAPPES--NFRRQISHP
LQGVP-PKKRGA-GQEDFLQKGRPGA--AGV---------Q-SRESGPAR-LF-MD----
SMADEARAIIRVVGQILLDKLGFRQGRG--------------PSEVNRHKG---DLHSQD
NV--HS-CC-------HQEHSREMCVLTCSPKATPKG-HDSPVKSRSS--RDSNW-----
------------------------TPRPKEPVS-PAG------HHHRPRVA--STSG--S
SI--HS--RRN-------------------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLFPYFSYLRYDDPP-------
SPS------------------PGKRKCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--RAC
PRG-------LE-ETWDLFS-QLQ------------------------------------
---------SLLGP---HPNKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------DSRSS---HETMEDTAP-M-------LSPLASPD PR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPPHTSD-------R--PSPPKAFPA
PPLQ--D--------------------------------------------STLIIPSHC
DS-VA--LPLGTVP-----QSLSLRK-----DLAAS--VPAISGLG-GS-NSQVST----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NNGSFLKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGKN----------------------SK---QLPSP QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTISPLLFQA----QPLS---------HPGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPID-----NSGVACPAS-QIKVQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPPRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDES-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDP--CPHLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENVLKAHVGR-KLGQINEGLIP-V
SVRRSRLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------ACVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CEPGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRQQVLTKASD-TPE----SL
-LASSPACKQFQR-APL-----GIPSWNDHGPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQVSR----AGETRE---------AEPQPRVPLGTRMLANLQA-TGDDVR-
GFEAPGTS-KSS-LLPKMSVSQDPRQLCLMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLVTENLAPQVP-QGHLQSMPTGN
MRAS-QELRDL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--MFPPLHKS-------ENSRKPNLEK
HEERL-EGLRTPQPTP------VRKTEDTRQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKKKSK-----------PAP--VTA---------E-SQKTGKNRSCV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARH--------------ASKVNQHKQ---EFQAPV
CRFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNRERQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTA--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MEKMLFPL-----KSLSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LYLLLSYLH-SDPPSPPP------
------------------GRKRSSREVPRHR---PLHH------NPVS------------
----------------------------------------------CL----PAC--RNL
LRE-------LE-ETRDLNN-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HLPLGGDPPGDVCKP
APA-K------AHQLHG--KC-MPDLSP-TSL------S------PA----A--------
--------------------------PPA PLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPPSPQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----THSVP-----KSSPLHS----QLLPSP--TRVISDLG-CS-SDPIRE----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDQP-LEASFW-
GDPTLRHVEVG--V-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-G-
EE--RERADH---------------------------------------PQMTSLGKEWD
ITTP-------NPFWNVSTE----------------------PQ---QLPRP QQVSDATA
VG-NHLQQKCSQLFWNLPS-FNSESLVATAW-VSSKSSSQ--NAHSVSLDEAST------
----------SLPGGPEVEVSSEISQA----PPSS---------QNAHS-V---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------SLD------EAST
--------------------S---------------------------------------
---------------------------------------LP---GE--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------P--------------------
------E-----------------------------------------------------
------------------VE----------------------------------------
------------------------------------------------------------
---------------------------------------------------HTLSVII--
----------------KTATLNYC----VPQRLQIFLSIVFDFGCP-KMFCHPQTIVLF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLIPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNR--KCF
QRE-------VE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---RHDTT-CF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSSLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PQ-LILSPD-LITSLADLFS-PSSLRDH--L
PPQPVSP---LDSKFHVDHS-----SPLQLPFP-LLPPRHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KSGSFPTQLR-----------------PNYQ-LNS-S--Q-----KMLSSMADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIS----QESQVFPPP----QPLS---------LPSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPALLPSPL--
-FRIR-----ICGVCFHRP-QNEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALARK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DP-ETSSD-EDLRS-NSERDLDT
Y--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEESHSQIKHQ-NLAALVSED------HGVDTSQEISFLS
PNKQKMLEAHIKSFRMRMLWGLP-RKILESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISWGDSKVGVSKFRRRS--SFQGEKLGTT---------SSVPVLDGPHPVTSPI
AKEGQDTLRRQYSDTDHDFIESDSKDGASTLLRRGTADFQGEILESTNSL--P-ILGHSP
-LVTSPVDQEKQG-TLG-----REFADTDNDLTE-SVPTTEDGGQTF--LPPAHSIIDEV
SQKQ---TVP-ASRSSTEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRKT------
FPV---------------TN----------GCALQSQNRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DMSLALENLSSKDL-LTHPQGISSGD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAIKR-------VSPMRPKGGE
LGGGD-ARLETSQLRRKSHAIHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSITYE-DQEISQAKGSSLS--SSV---------QN-RGRVTSRAAF-------
TGTTEAQKIRKDTRDSLGEKLGHKRGIDV-TCPQEPISFPVEL-GKAQHYPEVQVRAELV
QGYPHN-----YMAPSCK----LTCTKSCSQQAVFVG-QNYPTRIRQNTDKDRQPEKVEA
FKGKILCQR-HPQ-----------SV-----------------SLVCPAVL-ISAKS--T
VFSDVPLLTRQKILPKH--FQG------GKFPPTK-------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNR--KCF
QRE-------VE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---RHDTT-RF--------------------HRLLCPDPVCQVCNR
ATA-D------IQRL-LSQES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PQ-LILSPD-LITSLADLFS-PSSLRDH--L
PPQPVSP---LDSMFPIDHS-----SPLQLPFP-LLPPHHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GETSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLA-
GHSVANVIQPV--N-ISFVSH-DILALL-EREV-K------KR-------CDFLMWK-EN
GK--KSGSFPTQLR-----------------PNYQ-LNS-S--Q-----KILSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QQPPYSKC
FE-DHFEQKYVQLFWGLPS-LHSESLHPTVL-VKHGRSS-----MFVFFNGITN------
----------TSIS----QESQVLPPP----QPLS---------LPSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPALLPGPL--
-FRIR-----ICGVCFHRP-QKEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALARK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--NYHG----PL
H------------------SSSVESQSLSVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DP-ETSSD-EDPRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHRSWHSVK---QTM--SLPEESHSQIKYQ-NLAALVSED------HCVDTSQEISFVT
PNKQKMFEAHIKSFHMRMLWGLP-RKILESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISWGDSKVGVSKFRRRS--SFQGEKLGTT---------SSVPVLDGPHPVTSPV
GKEGQDTLRRQYSDTDHDFIESDSKDGVSTLLRRGTADFQGEILESTNSL--P-ILGHSP
-LVTSPIDQEKQG-TLG-----REFADTDNDLTE-SVPTTEDGGQTF--LPPAHSINEYQ
F-----------------------------------------------------------
------------------------------------------------------------
--------------SP-------RSIIILKNQMLNQLK--LVQRKDSQPSDHFT------
----------------------------------DTSIALENLSSKDL-LTHPQA-----
------VLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFSPATKR-------VSPRRPKGGE
LGGGD-AGLETSQLRRKSHAIHNKTSGELLGSKSSPTL---KTQPPPEN--LFRKCMKTF
LQRFNKPSITDE-EQEISRAKGSSLS--SSV---------QN-RGRVTRRAAF-------
IGTTEAQKIRKDTGDSPEEKLGHKRGIDV-TCPQEPVSFPVEL-GKAQHNPEVQVRAEPV
QGYPHN-----YMAPSCK----LTCTKSCSQQAVFVG-QNCPTRIRQITDKDRQPEKVEA
FKGKILCQR-HPQ-----------SV-----------------SLVCPAVP-TSAKS--T
VFSDVSLLTGQKMLPKH--FQG------GKFPPTK-------------------------
-

MGNLVIPLGKGRAGRGESGQRIPPPAPRPSVGCTGDDIALQMEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LFLLLLYVH-SDPPSPPP------
------------------GRKRSSREPQRERSGRSRSR-------KIS------------
----------------------------------------------AL----KAC--RIL
LRE-------LE-ETRDLNY-LLE------------------------------------
---------SHLRK---LAGEG-SS--------------------HLPLGGDPPGDVCKP
VPA-K------AHQPHG--KC-MQDLSP-ASL------S------PP----A--------
--------------------------PPA PLASTLSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKCP-----ATQPHVVFPPSPQPHG---PLAS---S--------
PPPP-----------------------------------------------DSRLAGLQC
GS-T-----TCPVP-----QSSPLHN----QVLPPP--TRVISGLG-CS-SDPIWD----
--------LY-CWREAAT---TW---GLST-----YSHGKSQPRHL--PDHP-SEASFW-
GDPTPKHMEVG--G-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-E-
KE--RKRADH---------------------------------------PHMTSLGKEWD
ITTL-------NPFWNVSTQ----------------------PQ---QLPHP QQVSDATT
VG-NHLQQKRSQLFWDLPS-LNSESLAATIW-VSRNPSSQ--NAHSVPLDKAST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQHFTPAWPQ
--SQPP-PLAEIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLGCSSP--
-TQIR-----GCGASYPTS-QERTQSVIPTGK----------------------------
--------------------EYLEWPL------KKR-PK---WKRVLPSLLKKSQAVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VVTSPELPEHWWQ-GRNAI-HQEQS---C
GP-PSRL-QASGDLLQPDGEF-------------------PGRPQS-Q--AEDTQQALLP
S-Q----------------PSEFAGKGRKDVQK---TGFRS-SGR---------------
--------FSEKGCLGSK---------LGPDPSRDQ-GS-GRTSV-KALD--EDK-EAEG
DLR--------RSWKYQSVSS----TPRDPDK-EHLENKLQIRLAR-KVGEIKEGWIP-M
PVRRSWLMAK---CAV--P---KSDTHRKPG-KLAS---WR---GGKAHANTSQELSFLH
PCTQQILEVHLVRFCVRHSWGTD-LQSLEPINVR---------SGEAQAPPFPQSTFTPW
ASW---VSRVESVPKV--------------------------------------------
----------------------------PIFLGKRPQNGPGDNRTTSKSV--P-TLSGSL
-AAPPPEQEGVQR-PPR-----GSQSADTHGRSE-AFPTGHKGRGCS--QPPTCSLVGRT
WQSR---TVLESGKPKPRLEG--SMGSEMAGNEAWLESESMSPGDPCSSKA-LQE-----
-----LSIGSQWAR----AEDALQALKVGE-K--PPTWEVTLGASVRASSGS-VQEDLR-
STGALGTT-GNP-SASSVCVAQDPEQLHLK--T---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ISRVVGQILVDKLGLQWGRG--------------PSEVNRHKG---NFHAQE
NV--PS-CC--HRGHCHQERSREMRALACSPKATPKG-HHCPVKNRGIRNRDSSW-----
------------------------APPPREPVS-PAGP-----HHHRPRMA--STSG--G
PH--PQ--LQELRSAQRCLAS---------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------G
ATA-N------ISHL-LSQAT-LEDGS--ASVSS---MDY--ITVSV------------T
LSFSLPENPLGNPTPDLPHEPSL------QSSSIISPH-QDTHLEDTLS-ASLLDDS--V
LSKSIPP---VNSKFSLDPD-----SLHLCTTFHLPQQHAP---QETELLLLQPVTALSL
VGSP----------RELFT-IPSNKSI-FSSRHAMSK-----------------------
------------------------------------------------------------
---------F-IQQQTDT---CD---SFRL-----EPAHLASQELL--DLHS-SGSYLQ-
RNITTCLTLPG--N-LPFPSL-DAMVLL-EKQV-G------KM-------ADSF------
-------------------------------------KT-W--G-----KTPE--SDQHN
LTVS-------HSLGSCK------------------------------------------
---DQLEPNHIQFFWGLPS-LHSESMNSIAT-VWVDSSL-----ISGCFN----------
----------------RFSDSPVLTNH----IPLS---------LPESQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLPQILSLSQ----SQPVPPAKPQ--LQ-----HPIPVLSPFSQ--
-SQIR-----ICEGVFSQT-QDKVQPLESSEI----------------------------
--------------------HCLNYNI------LKKELE---RVWGLPTVVKKSQEEFFP
PPPKPSLVKQ-----SFKTHVLKSIS--LGNFLLTSELRKKLENHLRKRLILQH-----W
GL-SKRI-YKSLPWVNPLAEL-------------------PETSSS-T--INYE----LS
W------------------LSFFKQQGSKDLHN---SVLNK-PGSFPARQS--------A
-EKLF--KAR-AHSTETI--------KKHQLWS----NT-KGTLD-NGLQS-NCEAILHH
H--------PGSLSGKPSG-----TSQVSQRQ-ENLETALQKHLAR--------------
---QSGYHPL----------PFTSQ------------VGKE------EHEAQ-----RQS
PSDK--KDGHVESKY---------------------------------------------
---------------------------------IM----T-----KSVLQQT--------
------------------------------------------------------------
-----------------------------------------------------SIILDNR
SLKE---S-E-SNKHSPDVL------------VPLGKRLYSSKTVQGPQGTKVNDK---S
IFLSNKV-----------S----NMVKGGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
----------------------------Q-------CHLVSP------------------
--------------------RHLVSQCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--ALP
---------------GHTRV-NLI------------------------------------
---------SLLGP---HPDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------ASRSS---HESMEDAAP-M-------LSPLASPD PR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPPHTSD-------R--PSPLKAFPV
PPLR--D--------------------------------------------STLIIPSHC
DS-VA--LPLGAVP-----QSLSPCK-----DLTAS--VPAISGLG-GS-NSQVSA----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NDGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSA QKLSDPRI
LQ-ERFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIH-----NSGVACPAS-QIKVQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------R
GN-LGRI-QESLDLMQLRDES-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDP--CPRLGQILGQT---------PQNLSR----GM-ESFPG-KVLGM-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENVLKAHVGR-KLGQINEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------VCVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSKVDV--------------------------------------------
----------------------------ATFLREPPMASLREQVLTKASD-MPE----SL
-LASSPACKQFQR-APP-----GIPSWNDHGPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AVPQPRVPLGTRMLANLQA-TSDDVR-
GFEAPGTS-RSS-LLPKMSVSQDPRQLCFMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLVTENLAPQVP-QGHLQSMPPGN
MQAS-QELRHL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--MCPPPHKS-------ENSRKPNLEK
HEERL-EGLRTPQPTP------VRKTEDTRQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKEKSK-----------PAP--VTA---------E-SQKTGKNRSYV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARH--------------ASKVNQHKQ---EFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNREKQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQSRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNW--KSS
QRD-------VE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-YF--------------------RRLLCPDPVCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLASSA SA----TE---SSFT
LASTPSATPPEDLILSPGPKPSP------PPPLILSPD-LITTLADLFS-PSPLRDP--L
PPQPVSL---LDSKFSVDHS-----PPQQLPFP-LLPPHHI---ERGEP-SLQTESRMAL
NTIFSFDSTLCQD------ISQAVNPTDSCAHHHEPPIP-SALPT-ED----C--TGTQS
KSR-------LTVLKSFP-EMLSLGDS---GGSSTS--APTIKGID-HS-RSASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEAFLG-
GHSVDNLIEPV--N-ISFLSH-DILALL-ERQV-K------KK-------SDFLMWK-EN
GK--KPGSFPKQLR-----------------PNYQ-LNS-S--W-----KMLASSAVKHG
LAES-------FPFWASKGK----------------------RD---QQHIH QQPPHSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQHGRSS-----MFVFFNGITN------
----------TSIS----HESPVLPPP----QPLS---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVKSQAQHQ-----SPFQALLPSPL--
-FLIR-----VCGVCFHRP-QNEAQSLMPSEI----------------------------
--------------------NNLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPVLVRK-----SFKVHVPISIL--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELFVS-E--SNHG----PL
N------------------ISSVEGQRHNVLKK---FGSST-PRNFHERSSNMLSL----
--ENV--GNYQRYSQEIA--------PKDHLLH----DP-ETSSD-EDLRS-NSERDLET
H--------MMHLSGNHS--------GDSLGQ-KQLENALTVHLSK-KFEEISENRVP-G
TVRSSWHSVK---QTV--SLARKSHSQIKHR-NLAALVSED------HRIDTSQEISFLS
SNKQKMLEAHIKSFCMRMLWGLP-RKVLESIEIF--------KSKEDLSTSFSHFDLPSS
ATF---IPRGDSKDGVSKSRRRS--TSQGEKLGTI---------SSVPVLDRPHPVSSPV
GQEGQGALRSQFSDTDHDLIETDSKDG------RGTTDFQSEKLESTSSF--P-ILSHSH
-LVTSPVDQEKR-----------EFSDT--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------DMILQKDL-LTNSQGISSQD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPMHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFSPATKR-------VSLLRPNGGE
LGGGA-AGLGISQPRRKSHPVHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSISYE-EQESSQEKGSSLS--SSV---------QN-IGRVT-RAAF-------
TGTIEAQKIMKDTREFLEEKLGHRHGIDI-TCPQEPLSFPVGL-GKAQHNSEVHVRAEPV
QGYPCN-----YMAPSCK----VTSTKSCSRQAIFVG-QNYPTRIRQIIDKDRQPQKVEA
FKGKILGQS-HPQ-----------SMPHRKPVPHSNPTCRRQVSLVCPAIP-TSAKS--T
VFSDVPSLTGQKMLPKH--FQG------GKFPLAK-------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNTP--SSTPWVLDIFLTLVFALGF-------FFLLLPYFSYLRCEDPP-------
SPSP------------------GKRKCPVGQRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--LVP
-------------------P-GSC------------------------------------
---------SLLGT---HLDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------ASRSS---REPMEDAAP-I-------IYPLASPD PR----IK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LLLEHP-----SPKPPALFSHPPHTPD---PLACS--PPPPKDFTA
PPLW--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLAAS--VPAISGLG-SS-NSQVSA----
--------FS-WWQETTR---TWC-----------Q-------DHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GIQV-T------ER-------AKVNIWE-E-
KE--NDGSFTNQMT-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
TTTP-------KSFWNKREN----------------------LK---ELPSP QKFSDPRL
LQ-ESFQKNYSQLFWGLPS-LYRESLVANAW-VTDWSCTL--QSPPF-FNQISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFW----PTPMAQAEAQAHLQ-----SSFPVPSPTFP--
-SPIK-----NTGVACPAS-QNKVQALSLSET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQH--------------T
GQ-PGRI-QESLDLMQLQDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKETQK---VK---------------LQ-----
LERDP--CPHLGQILGET---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-NHIENILKAHMGR-KLGQINEGLIP--
--------------AF-----PMSNTHMKTN-NLAPLKSGK------ACVNTAQVLSFLE
PCTQQVLGAHIV------RWGLP-LRVLKPIQCL--------KLEKILSLCSTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRKQVLTKASVHMPE----SL
-QAS----------SPA-----WIPSWNDHGSLK-APTAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----ARETRE---------AEPQPRVPLATCMMANLQA-TSEDVH-
GFEAPGAS-KSS-LLPRMSVSQDPRKLCLMEEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHASENLASQVP-QRHLQSMPTGN
MQAS-QGLCDL---MAARRSN--LRH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSP--MFPPTHKS-------ENSRKPNLEK
HEEMY-QGLRTPQLTP------GRKTEDTRQNEGVQLLP-SKKQPPSIS--HFRENIKQL
FQR--------------------PAP--VTA---------E-SHKTVKNRSCV--H----
SSSAEVQELMTSVGQMLEEKMSLCHECH--------------ASKVNQQRQ---QFQAPV
CGFPCN-----HRHPFYSEHIRMLNYAASSQQATPKS-QSCPNRDRQIRDQQ--PLKSVW
CNNEQWA------------------------VS-PVSP-----PQHGPKIP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQGRARRK---RKSV-------------------
----------------------------------------------TFKDQ-KS-----F
QKE-------AE-EERKLLS-FLK------------------------------------
SFG-PPASCSPLGQ---HHDIT-RF--------------------RRLLCPDPICQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLASSA SA----TE---SSFT
LSSTPSATTPEELILSPRPKPSP------PPPLILSPD-LITTLTDLFS-PSPLRDP--L
PPQPVSP---LDSEFPIDHS-----PPQQLPFP-LLPPHHI---ERGEP-SLQTESSLSL
NTIFSFDSTLCQD------ISQAVNPTDSCAHHHEPPIP-SALPT-ED----C--TGTQS
KSR-------LTVLKSFP-EMLSLGDS---GGSSTS--APTIKGID-HS-RSASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVDNVIQPV--N-ISFLSH-DTLTLL-ERQV-K------KR-------GDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--W-----NMITSIAVKHD
LAES-------FHFGDSKDK----------------------LE---WQHIH QKPPYSKC
SE-DHLEQKYVQLFWGLPS-LHSESLYPTVL-VQPGHPS-----VFVFFHGITN------
----------TSIS----HESPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSEAQHQ-----SPFQALLPSPL--
-FLIR-----GCGVCFHRS-QNEAQSLMPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPVLVRK-----SFKVHVPISIL--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSK----------------------------------------
---------------------NFRGQRHNVLKK---SGSSI-PRSFHKRSSNMLSL----
--ENV--GNYQGYSQENA--------PKNHLLH----DL-ETSSD-EDLRS-NSERDLET
H--------MMHLSGNHS--------GESLGK-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWQSVK---QTM--SLAEKSHSQIKHR-NLAALVSED------HRIDTSQEISFLS
SNKQKMLEAHIKSFYM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLIPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNR--KCF
QRE-------VE-EERKLLF-ILK------------------------------------
SFG-PPVSCSPLGQ---RHDTT-RF--------------------RRLLCPDPVCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSSLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PQ-LILSPD-LIASLADLFS-PSSLRDH--L
PPQPVSP---LDSKFPVDHS-----SPLQLPFP-LLPPRHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHYKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLA-
GHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDLLMWK-EN
GK--KSGSFPTQLR-----------------PNYQ-LNS-S--Q-----KMLSSMADKHD
LAES-------FPFRAIKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIS----QESQVFPPP----QPLS---------LPSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPALLPSPL--
-FRIR-----ICGVCFHRP-QNEAQFLTPSKI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALARK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSST-PRSFHERSSNMLSL----
--ENV--GNYQGHRQENG--------PKNHLLH----DP-ETSSD-EDPRS-NSERDLDT
Y--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEESHSQIKHQ-NLAALVSED------HGVDTSQEISFLS
PNKQKMFEAHIKSFHMRMLWGLP-RKILESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISWGDSKVGVSKFRRRS--SFQGEKLGTT---------SSVPVLDGPHPVTSPV
AKEGQDTLRRQYSDTDHDFIESDSKDGASTLLRRGTADFQGEILESTNSL--P-ILGHSP
-LVTSPVDQEKQG-TLG-----REFADTDNDLTE-SVPTTEDGGQTF--LPPAHSIIDEV
SQKQ---TVP-ASRSSTEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRKT------
FPV---------------TN----------GCALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DMSLALENLSSKDL-LTHPQGISSGD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAIKR-------VSPMRPKGGE
LGGGD-AGLETSQLRRKSHAIHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQRFNKPSITYE-DQEISQAKGSSLS--SSV---------QN-RGRVTSRAAF-------
TGTTEAQKIRKDTRDSLGEKLGHKRGIDV-TCPQEPVSFPVEL-GKAQHYPEVQVRAELI
QGYPHN-----YMAPSCK----LTCTKSCSQQAVFVG-QNCATRIRQNTDKDRQPEKVEA
FKGKILCQR-HPQ-----------SV-----------------SLVCPAVL-ISAKS--T
VFSDVPLLTRQKMLPKH--FQG------GKFPPTK-------------------------
-

-----------------------------------------MENILCFL-----NSYTES
---GLSPG--LVHCLDIDPNFICLSGLGL-------FMLYLFYVL-LTLYLSPP------
------------------GKNDDIQMHQGRARRRK---KGG-------------------
-------------------------------------------------TF-KDR--ITF
QKE-------AE-EERKLVS-FLK------------------------------------
SFR-PPASCSPLGQ---HHDTT-RF--------------------RRLLCPDPLCVVCNR
TTA-E------VQRL-LCWES-LKDTAP-----S---VSSLASAA SV----TD---SSFT
LASAPSTTPPEHLILSPCPDASL------PPPLILSSD-LITPLTDLFS-PSPLRDP--L
PPKPVSP---LDSKFPIDHS-----PPQRLPFP-LLPPHHI---QRAEP-ILQPEASLSL
NTIFSFDSTLSQDMNSLPNICQAMNPCDSCTFHDKPPNS-SALRM-QD----C--TVTQS
KAS-------LIILKPLEKETLSVDGS---GGSTTS--ASTIGDID-HS-WPASAE----
--------FS-WWQPHVK---DSF---SS-----NFVPSDFMQELL--SLHS-SEASLG-
RYSVVNLIVPV--N-LSFVSH-DIVALL-ERQV-K------KR-------GDFLMCK-EN
GK--KPGTSPKHLR-----------------PNYQ-LNS-S--G-----KMLSSIAGKHG
LAAS-------LPFWASNRK----------------------VE---RLHIH QQPPYSKC
FE-DYLEQKCVWFFWGLPS-LHSESLNSNVL-LQCGCSS-----MFVFFNEIAS------
----------MSTF----QEPPVLPHL----QPLS---------LPITQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLCQTLPQGQ----SL--------SQHP-----SPLTAQLPSPL--
-FQIG-----ICGVCFHKS-QNEAQSLTPSEI----------------------------
--------------------NHLEWNV------LQKLLE---SVWGLPSVVQKSQEDFCS
PAPSLGLV-K-----SFKACCPISII--PGDFPLSAEFRKKLEHHIQKRLIQHR-----W
GL-PRRI-HESLSLLRPQSPI-------------------VEISES-E--NSEG----PL
H------------------KSLVEGQSHNDLKN---FKSRK-PRSFHKRSSNMLSL----
--ENV--GKFQGYSQENG--------PKDHLLH----EP-ETSSE-KDLSS-NSESNLEG
H--------MMHLPGNDL--------GVSLGQ-KQLANALTVHLSK-KFEEISKGQVP-W
SVRSSWHSVK---QTI--SLPEKSHSQANHQ-NLAALVGED------YCIDTSQEMSFLG
SNKQKMLEAHIKSFHMRMLWGLP-SKVLESIEIC--------KLQEDLSSSFSHLYFPSL
ATF---IPQEDSKDGFSKSLRQS--TLQEEKLGTT---------SSIPILDHPDPV----
------------SDIEHNLTEMDSKDGASNPLRGSTTDFQGKKIETTSLS--Y-ILDHPH
-PVISPVDKERQE-TLR-----RDLFDTDNQLIE-TVQKPDNGRQTF--LPPTHGIIEEV
SQKQ---NVV-ASRSSPEL-P---IMQTGAGGESMDEKESCSNNVERIQSSRKT------
YPV---------------TSGFL-----------QSQTRNNSTTSKSGSSSV-IKGKIS-
-T---LET--E-NFSPKISVPQDPKSSSLKHQMFSELK--LAQGEHSQAQTHFT------
----------------------------------DMPLALDNLTSKGL-LTHVQGISSGN
MATS-QVLNVH---MEDRGIH--VLQ-QQEPSVPKHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------NCQVK--NFPPATKR-------VSPPRLKGGE
LGGGN-AGLGTFQPRRKSHPVQKKTSVEVLGRKSSPTL---ITQPPPEN--LFRKCLKTF
FQRFKKLSITCE-EQDSSQAKGSSLS--SSV---------QN-RGRVKSRAAF-------
SGTTEAQKIKTDIVKFLKEKLGHRNGIDI-TCPQEPLSSPVEL-GKAQHEPELQVRADPV
QGYPCS-----YMAPSCK----VTCSESCSQQAILVG-QNHPTRIRQIIDKNRQPQKVET
FKGKILCQR-HPQ-----------SIPHRKPVPQPNPTCQCQVDPVPPAIP-TTAKS--T
VFSDLSLLITQKIFSKH--FQG------GKFPPTK-------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKCPVGRRRRPRGR------MKN-------------
---------------------------------------------HSL----RAG--REC
PRG-------LQ-ETSDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--PPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-RWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TYQMEAG--S-LFLLSS-DGQNAV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTDRMT-----------------PEKH-LNS-L--R-----NLAKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
WQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPPS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRRQLE---GRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
RVRRSWLAVN---QAL-----PVSNTHVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQGLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPAWKQFQR-APR-----GIPSWNDHGPLK-PPPAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDMH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVNEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLVSQVP-QGHLQSMPAGN
MRAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KNQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSVS--HFGGNIKQF
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
SSSAEAQGLMTAVGQMLDEKMSLCHARH--------------ASKVNQHKQ---KFQAPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----LQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAW
---SLNAP--SSTPWVLDILLTLVFAVGF-------FFLLLPYFSYLRCEDAP-------
SPS------------------PGKRKCPVGHTGRPRRR------TKN-------------
---------------------------------------------HSL----RAC--RAC
PRG-------LE-ETWDL------------------------------------------
----------LLGP---HPDKG-DF--------------------GQLSGPDPRGEVGKR
APD-G------SSRSS---HEPMEDAAP-V-------FSPLASPD PR----TK-------
--------------------------HPQDLASAPSPG-PMTTSV------SSLSAS--Q
APEPS---------FPLERP-----SPEPPALFPHPPHTPD---PLACS--PSPPIAFPA
PPLR--D--------------------------------------------STLIIPSHC
DP-VA--LPLGTVP-----QSFSPRK-----DLAAS--VPAISGLG-DS-NSQVSA----
--------FS-WWQETTR---TWC-----------IFNSSVQQDHL--SHHP-PE-----
----TCQMEAG--S-PVLFNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NDGSFSKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSP QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----SIPMAQ----AHLQ-----SSFPVLSPAFP--
-SPIN-----NSGVACPAS-QNKLQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKFQDVFSV
STPNLPQESL------------PSIL--PENFPISPEVRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDES-------------------SGTSQV-K--GEPR-----P
W-Q----------------SSTSTGKSSKEAQK---VK---------------FQ-----
LERDP--CPHLEQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ELER
DLR--------KPLRSDSG-----------KR-NRIENVLKAHVGR-KLGQMNEGLIP-V
SVHRSWLTVN---QAF-----PMSNSHVKTS-NLAAPKSGK------ACVNTAQVLPFLE
PCTQQVLGAHIGRLWAKDRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMESLRKHVLTKASD-MSE----SL
-LASSPACKQFQR-APP-----GIPSWNDHGPLK-APPAAQEDKWPS--KPFTYSLTGST
EQSR---RL---------------------------------------------------
--------GAQSSR----AGEIRE---------AVPQPRVPLGTRMLANLQA-TREDVC-
GFEAPGTS-KSS-LLPKMSVSQDPRRLCLMEEVISEFEPGMAMKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLAAENLAPQVP-QGHLQSMPTGN
MQAS-QELHGL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--IFPPTHKS-------ENSRKPNLER
HEERL-DGLRTPQLTP------VRKT----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-R------KK-------MSLQTLE-EV
KR--RDGISPDPRR-----------------SEGK-PTA-P--W-----NSPGSTVTNLD
TQVP-------KINLKMKGK----------------------RK---YLEASDQVLCVKI
PE-GDLGQNHSQLFWGLPS-LHSESIMATLL-VPVSSYSP--EPCLVLFNGVCK------
----------AASGPVLSHGFPALPQP-----------------LTLVH-PQPLPKVA--
P--QPQ-TLTEE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MPQ----AHMQ-----SPWSSMA-LPS--
-LPYG--------SALQIP-QTRAVSDVINGK----------------------------
--------------------GHLQYHL------VQNPQD---SLWGLVPECQQYETALGL
PVHSFPVGSQ-----SSQTYVSVP-G--SGLFHFSSEHQNNLDPYGPNNLTSPS-----C
FEL-CSR-PGVPEVMNTQFKP-------------------TGVSSY-N--YKYA-----K
S-Q----------------CCVHWGNICADPGN---GELSH-SESYCMKVPMKPQL---R
--KDA--AKNLGQILGKC--------PLDNTQM----IS-GCCIL-NGLKA-IPET--EG
ELA--------YHSRTDLENEQLTISKKNLDQ-RHMRSILRLHMSR-KCWQITMGRIP-I
MVCCSWLTED---ASL--WRSPL---------------GKI------HCDTAIPEIPFLD
RKTQKMLEAHLIRFRVSQQWGLP-IKVIESIKFY--------ILREAKTWPLSQSDLPLS
LNS---IPGLDLKSNF--------------------------------------------
----------------------------PSPLRGSSDLLHGDKIETTDSA--PTS--DYS
-LTLLHVDSEGER-SLR-----QSVSSHTSDVSE-TVQTVEDDRP---------SN-PDL
SQNK---AELQSRPRQ--E-Q--PIKEDVTPSDSENERASSASHLVIAESRLSVE-----
-----KNPKY-TVT----PNMLREMILKARELFVRSGSDSIIKSESSTKKD-------E-
SLSSPLVA-TGQ-SSSRMSVPEDPTAPDFKKQLFKELRSKLEDQPQSQSEAWED------
----------------------------------ESSFVSDSFSGYSL-PSSSNSVSSAD
VSVF-WDTQSH---MYSTGIS--VDP-WQEPSV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRILK--NFIPAQKR-------LALPVSRKEN
GRSDP-QELETPKAGKKSQPSKEKS-------------G-K-REHPPDS--YFRKKIGQF
FQWLY-SSKDSP-R-----------------------------HKSEKDRALF-MS----
CGPPEAHELMASLGKLLEDKMLYGQKSE--------------FLEWSQTTMP-AQ--PAL
KG--QP-SN--LGA-ANGHHGE-ASNCSCPQTAITPG-PSHML-SLGQRHRPVP-FEYP-
PSAPESLSS-VQA-----------PLA---------------------------------
------------------------------------------------------------
-

-------------------------------------MEFRKWNVLSFL-----NSPTDP
---YLSFG---STSLDIDSDLIFLCGLGL-------FLLFLWYLV-GFPCLPTF------
------------------CKIKSIQKHQGRTRRR---PKGG-------------------
----------------------------------------------TLK----GC--RFH
QIE-------TE-EKTKLIS-ILK------------------------------------
---------SPLGR---HDDTI-HF--------------------RQLLCPDPFCEVCNN
ATA-E------VNWL-LFPET-LEDSAS-----S---MSPLASTA PV----AD---SSLT
LSPAFSAVSPGDLLPASLPEPSP------LPLSILSPS-SMNPLADFLS-PSPLGHT--L
ALEPFTS---LDSEFSVDYS-----SPQPLAFP-PLLPHDM---QTACP-VLPPEATLSL
NTIFSLDPTLSHNINRLSDLSQAMKPADSF----APPSL-SVLPQ-PD----CTLTVTQA
KSV-------AILLTPVP-ENLPTESP---GVLSPY--VPTLTGID-HS-SLSISD----
--------FS-WWQAHAK---DLI---PS-----TLAQCDFNQEFL--ALHS-SEASFG-
GDPAANLIEPG--N-LSCLSP-DVLALL-ERQV-Q------KR-------SDFLMWK-EK
EK--KKDSFPEQLR-----------------PDSQ-LNP-S--G-----IMLESVADK--
-------------------------------------------------PVH QQPPYPKT
VE-DQLQQKPTQLFWGLPS-LHSESLPSAVH-VSSDSSS-----NFI-FNRNSN------
----------ASTG----QESPGLPHP----QPQF---------LPEIQ-PE--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQSQ----PLPLTQVQSQADPK-----SPLLVTPPGPL--
-PQVR-----ICGVYFHRP-QNESESLSSSEI----------------------------
--------------------QQLEWNV------LQKQQE---SLWGLPSVIQRSQEAFCP
LAPNTSHHQH------PQAHVSVSIL--PGEFALSDELRKKLEHHLRKRLIQHR-----W
GL-PRRI-KESVSLMLPPDGF-------------------LEASKS-E--SSDG----VS
L------------------ISVFKGQSSKHV-S---VELIQ-PGSFRERSSEML-----Q
LEKDV--GKDQEHSQENG--------QEDHLLK----DP-NSSSN-KDLGY-DSEKNINS
Q--------IVSLSEKNLR-----GSAESL----QLENVLKVHLSK-KFEEINEGRLP-G
TVHSSWHAIK---QTL--VLSAKSHTEMKER-SLPSPVGEC------YSLNTFQDLTFVD
PSAQQMLEAHIKRFRMRMLWGLP-SKVLESIQIF--------KLKDASSQSLSHASFASS
TNA---ISEPDSKFGNSKSFR-SSKSFHGNKVGTT---------NSAPVLGHCLP-----
------------------------------------------------------------
--ATSLVGKEGQR-VLR-----QSHSAVNHELAE-DVQKIKDPRQIC--LPVSLCITGRG
SHRQ---VQL-ADGYPRKP-L---AKQAGARFEPKYKSMSSSDKGKMQQGKKV-K--SEP
VSM---------------PKVSREIFKAEELECLQLKTNDMLTTNKSGSSQI-TNVNEN-
KAETTVTT--E-SPPPKLPVPQDPKRVSLKEQLLDELKFRLEKRKHSEAEGQPM------
----------------------------------DMSLASDNLTYKAS-PIPGQGISGGD
TGES-QVLHVH---VEDRGIR--MEQ-QEEPWVPKHG--FQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------RCQDK--NFPPTVKR-------VSSSECRAKE
LGGGD-AGLGTSQLRRKSFPPQETVREEMLVSKSSQTLS-KKGQSIPEG--HIRKRMKHF
LQWLY-PGEKRK-RREDPQEKGSPI---SSG---------QS-RRLVKSRSAA-------
TGSTEAQKIVTDIRKFLEEKLGYQHALDL-TSSQEDPLSPVHF-GQSQKKAVVLVHTEPV
PGHPFN-----FNAS-SK----VTNPKSRHQEAIFAG-QSYHPSTRQIRNKKRQPQKAVA
FKDQQLYQK-HPP-----------PVSHREPVPHPSPTHRCQAGQACPAAP-TTAEG--N
VSRDLSLLFRQKTLQNF--QGG------K-LPI---------------------------
-

----------------------------------------EMENYLFPQ-----KYIIAS
---WLSSG---PTSWAINIIFTFLCGLGL-------FFLLFSYFR-NDASLPPH------
------------------EKHRNSRKHRVEPQRRSSRS--QKKAQTLK------------
----------------------------------------------TL----KAC--RDC
LQE-------LE-EVRELIS-LLQ------------------------------------
---------SHLGR---FPDQE-AF--------------------HQLLYQEAPEEVSKA
ASA-G------AHQPCS--EP-GEDAAP-ILV------P-SPSPAPL----TG-------
--------------------------CPLPLASTLSPS-PTTSSISLLS-HFSLSAS--W
PPEPF---------LPLDGF-----SHQSLALSPSLPSLPS---SEAC---TPALTDSSA
PAWP-----------------------------------------------DSTLTLPLC
DS-MA--PPLGTIP-----QSSSPRTPWLA----SP--VPVISGLG-YS-SCPISA----
--------LS-CWQATAK---AW---SFST-----STHLESQQEPL--SHQP-PEVLLW-
GDSTNRQVEAN--I-PSFINP-DIQKLL-EILI-T------KR-------IELKMGR-R-
KG--QMX---------------------------------------------FSTQDG--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------DILPCIR-E-ETPSFISTAI----------------------------
--------------------QNLECHF------LKKQLE---RDRTLPAVVKRSQEVFNQ
VSPNFLQDDQ-----DPEAHESISVL--PE-DLISPELREQLEWHLWKRFMRH--Q---S
GL-PHKI-QLSVKLIQPQDEA-------------------LKVTQA-H--SQRR-----P
M-W----------------PSASRDRSCQAVQK---TGSRN-PAR--------TMP---G
--KKL--GKDTRSSVRKI---------QKDLCR----GS-STSPW-KEPGK-GSE-ESDP
DMMKR--------------------STSSQDK-KHPEKILRTHLGR-KLGQIREGQIP-V
DVHRSRLAVN---HAS--DLPGKPSIHRKTG-KPATSKGWK------PCMTTSHDFSILS
PYTQRMLEAHIIRFRVKHRWSLP-LKVLKPINLF--------KLKKGSI--FPWSSTPHP
ATS---ISKACS---K--------------------------------------------
----------------------------AKFLGKPPQPHRGEKEITKEAV--P-PSETPL
-PAPQPTCEEIPQ-TLE-----GISLGEGHGPPE-APVAGQEARPPP--QTLTYSFVGRI
WHSE---TVLGAFEYS-SLES--SPSPATATSEPRRETGGWTSRDSCCNVT-VLE-----
-----LNLESQSLS----AKESREAAESE--E--APAWGDTLEPSVLPNDQT-IHVDLR-
RSGSSGGS-NGP-SASVKLVAQDPEEPCLDEQL-RESAVQRLAESENQPQAPVSNVLL--
-------EDCETGVILQDCATNSL----LQECQSNMFLAADMLASQGS-LSDFQSLSSED
ASTS-QMLLGL---VSSGQDS--QWQ-P-ETLV--LQAPS--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------RSQSK--LSIPAQER-------EYYRRPNAGE
HEEEV-EELKVFQISEMNHRSLDKASPEPSRSKFCPVLL-KKEEVPPES--QFRRKVRHF
LQWIF-PGK-GK-GQKDPGPKGKPSP--TSA------------QNRASGR-SA-VG----
RGPAEAQVLVTAVGQILEEKMVPHQGLR--------------APECNCYKR---DQQAAA
GP--NV-CY--HRVLSYQEQRRVMRETASNQQAIPKG-HSCPNRAEWILGRDNRW-----
------------------------AFPSRVAGC-PGRA-----CQHRPMVP--GASG--H
PPHPHC--PRHC-LFQRYVSS---------------------------------------
-

-----------------------------------------MEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LYLLLSYLH-SDPPSPPP------
------------------GRKRSSREVPRHR---PLHH------NPVS------------
----------------------------------------------CL----PAC--RNL
LRE-------LE-ETRDLNN-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HLPLGGDPPGDVCKP
APA-K------AHQLHG--KC-MPDLSP-TSL------S------PA----A--------
--------------------------PPA PLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPPSPQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----THSVP-----KSSPLHS----QLLPSP--TRVISDLG-CS-SDPIRE----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDQP-LEASFW-
GDPTLRHVEVG--V-CTFIHP-DVQRLL-ETLI-A------KR-------ALMKMWQ-G-
KE--RERADH---------------------------------------PQMTSLGKEWD
ITTP-------NPFWNVSTE----------------------PQ---QLPRP QQVSDATV
VG-DHLQQKCSQLFWNLPS-FNSESLVATAW-VSSKPSSQ--NAHSVSLDEAST------
----------SLPGEPEVEVSSELSQA----PPSS---------QNAHS-V---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------SLD------EAST
--------------------S---------------------------------------
---------------------------------------LP---GG--------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------P--------------------
------E-----------------------------------------------------
------------------VE----------------------------------------
------------------------------------------------------------
---------------------------------------------------VSSELS---
----------------QGGATDLC----LPGHHVDMLPATDRLPAQ-APLSTPQSVSSKN
PTAS-QGPWAL---LWKGTDS--PGQ-R-EPGSPKAKAPQKS--QKTLGSADKDEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HRRPRPGE
QGHGS-KGPTTSEASGRSHSAHTREIGDKQERKYNQPQP-EKGETPPES--HFRRKIGHH
PRGLH-PRKTGA-RWEDVLEKGKPGA--DAV---------Q-SWGSGPAR-LF-MD----
CMVDEAWTISRVVGQILVDKLGLPWGRG--------------PSDISRHKG---DLHAQE
NV--PS-CG--HRGHCHQEHSREMRAPACSPKATPRG-HHCPVKNRNIRDRDSRW-----
------------------------APPPREPVS-PAGP-----HHHRPRVA--SASG--G
PI--RG--RWN-------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSLD---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------KKNNDIQKIRN-------------------------------
-----------------------------------------------------YR--KCF
QR----------------------------------------------------------
-------------E---HHDTT-RF--------------------RQLFCPDPVCQVCNR
AAA-D------IQRL-LSRES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PPQLILSPD-LITSLADLFS-PSSLRDP--L
PSQPVSP---LDSKFPVDHS-----SPLWLPFP-LLPPPHI---QR---------ANFCL
NTTFSLDSTQCQD------ISQVMNPTDSCAHHYKPPIP-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPCAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEVSLG-
RHSVANLIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----KMLSSIADKHD
LAES-------FPFRASKCK----------------------LE---GQHIH QEPPYSKC
FE-DHLEQKYVQLFWGLPS-LRSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSLF----QESPVLPPP----QPLS---------LLSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SLPQTLPQGQ----SPHLTEVQSQAQHQ-----SPLPALLPSPP--
-FLIK-----ICGVCFHRP-QNEARSLTPSEI----------------------------
--------------------NHLEYN------------E---SVWGLPSVVQKSQEDFCP
PAPNLALVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQHR-----W
GL-PHRI-HESLSLLRPQSKI-------------------SEQSAS-E--TIQG----PL
H------------------SSSVEGQSLNVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNYLLH----DP-KTSSD-ENPRS-NSERDLNT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHT----------LVSED------HCVDTSQEISFLS
PNKQKMLEAHIKSFCMRIGDLCS-S-ITN-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLFPYFSYLRYDDPP-------
SPS------------------PGKRKCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--RPG
PRG-------LE-ELWNLFS-QLQ------------------------------------
---------SLLGP---HPDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------DSRSS---HEPMEDTAP-M-------LSPLASLD PR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPPHTSD-------R--PSPPKAFPA
PPLR--D--------------------------------------------STLIIPSHC
DS-VA--LPLGTVP-----QSLSLRK-----DLAAS--VPAISGLG-GS-NSQVSA----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NDGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSP QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIH-----NSGVACPAS-QKKVQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------Q
GN-LGRI-QESLDLMQLRDEL-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDP--CPRLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENVLKAHVGR-KLGQINEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------ACVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CEPGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRQQVLTKASD-MPD----SL
-LASSAACKQFQR-APL-----GIPSWNDHEPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AEPQPRVPLGTRMLANLQA-TGDDVR-
GFEAPGTS-KSS-LLPKMSVSQDPRQLCLMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLVTENLAPQVP-QGHLQSMPAGN
MQAS-QELRDL---MAARRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--MFPPLHKS-------ENSRKPNLEK
HEERL-EGLRTPQPSP------VRKTEDTRQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKKKSK-----------PAP--VTA---------E-SQKTGKNRSCV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARH--------------ASKVNQHKQ---EFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNRERQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MENILCFL-----NSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYVV-LTLYLSPS------
------------------EKNNDIQKHQGRPRRR---RKGG-------------------
----------------------------------------------TLKDG------KSF
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
QREPVSP---LDSKFPVDHS-----PPEERPFP-LLPQHHI---QRAEP-NLYPVASMSL
NPTFSLDSTICQD------ISQAMNPTDSRAHHHKPPIP-SALPS-ED----C--TVTSL
KSR-------LTILKPFL-EMLSLGGS---GGTSTY--APTIKGID-HS-CPASSE----
--------FS-WWHPHAK---GSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ER-----------Q-------CDLLMWK-EN
EN--KAGSFPTQLR-----------------PNYQ-LKS-S--W-----KMLASIADKHD
LAAS-------LTFWASKGK----------------------LE---GQHIHQQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VKHGHSS-----MFVIFNGITN------
----------TSIF----HKFPVLPPP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQSHNQHQ-----SLLPALLPSPP--
-FLIR-----ICGVCFHRP-QNEARSLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---S-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------Q -KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NLAALVSED------HGVDTSQEISFLS
SNKQKTFETHIKSSHR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNW--KCF
QRE-------VE-EERKLLS-ILK------------------------------------
SFG-SPVSCSPLGQ---RHDTT-RF--------------------HRLLCPDPVCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPRPKLSP------PQ-LILSPD-LITSLADLFS-PSSLRDH--L
PPQPVSP---LGSKFPVDHS-----SPLQLPFP-LLPPCHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWHPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLA-
GHSVANLIQPV--N-ISFVSH-DILALL-ERQV-K------ER-------CDFLMWK-EN
GK--KSGCFPTQLR-----------------PNYE-LHS-S--Q-----KMLSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QQPPYSKC
FE-DHFEQKYVQLFWGLPS-LHSESLHPTVL-VKHGRSS-----MFVFFNGITN------
----------TSIS----QESQVLPPP----QPLS---------LPSTR-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQVQHQ-----SPLPALLPGPL--
-FRIR-----ICGVCFHRP-QNEAHI----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------IDEV
SQKQ---TVP-ASRSSAEL-P---IMQAGVGRESKDKRESASNNVNRLQGSRKT------
FPV---------------TN----------GCALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DTSIALENLSSKDL-LTHPQGISSGD
MGTS-QVLHVH---LEDRGIC--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAIKR-------VSPRRPKGGE
LGGGD-AGLETSQLRRKSHAIHNKTSGEVLGSKSSPTL---KTQPLPEN--LFRKWMKTF
LQRFNKPSITDE-EQEISRAKGSSLS--SSV---------QN-RGRVTRRAAF-------
IGTTEAQKIRKDTRDSPEVKLGHKRGIDV-TCPQEPVSFPVEL-GKAQHNPEVQVTAEPV
LGYPCN-----YMAPSCK----LTCTKSCSQQAVFVG-QNYPTRIRQNTDKDRQPEKVEA
FKGKLLCQR-HPQ-----------SV-----------------SLVCPAVP-TSAKS--T
VFSD-------KMLPKH--FQG------GKFSPTK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
--------------------------PQRERRGRSRSR------KKIS------------
----------------------------------------------A-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LKAPLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPPSPQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----TRPVP-----KSSPLHS----QLLPSP--TRVISDLG-CS-SDPIQE----
--------LY-CWREAAT---TW---GLST-----CSPGKSQPQHL--PDQP-LEASFW-
GDPTPRHVEVG--V-CTFIHP-DVQKLL-EALI-A------KR-------ALMKMWQ-G-
KE--RERANH---------------------------------------PQMTSLGKEWD
ITTL-------DPFWNVSTE----------------------PQ---QLPRPQQVSDATA
VG-NHLQQKCSQLFWNLPS-F NT-----------------------------ST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQPFTPAWPQ
--SQPP-LLAGIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLPCSSP--
-PHIR-----DCGASYPTT-QEKTESVIPAGK----------------------------
--------------------ENLEWTL------KKR-PK---WKRVLPSLLQKSPAVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VATSPELPEHRWQ-GRSAI-HQEQS---C
GP-PSRF-RASGDLPPPEGEF-------------------PGRPQS-R--AEDTQEALLP
S-Q----------------ASGFAGKGRKDVQK---TGFRS-SGR---------------
--------FSGKGCLRSK---------PGPDPSRDR-GS-GRTSV-KFLE--EDKEEAEG
DMW--------RPWKYQSVNS----APRDPDK-KHLENKLQIHLAR-KVGEIKEGWIP-V
PVRHSWLMVK---CAV--P---QSDAHRKPG-KLAS---WR---GGKAHANTSRELSFLQ
PCTQQMLEVHLLRFRVRHRWGPD-LQSLEPINVW---------SGEAQAPPFPQSTFPPW
ASW---ESRDESAANV--------------------------------------------
----------------------------PILLGKRPQNGPGDNRTRSKSV--L-TVSGAL
-ASAAP------E-PLR-----GSQSADTHGRSE-AFPSRHEDRGFS--QPPTCSLVGRT
WQSR---TVLASGKPKPRLEG--SMGSEMPGNEARFESESMSPGDVCSSRA-L-------
----------QWAR----AEDALEALRVGEEK--PPAWDVTMGASVRASSGS-VQVDLR-
SAGALGTT-DNP-SGSTICVAQDPEQLRLKAQVVNEIALLVQVDSVEQPPGRASGVLL--
----------------QDGAIDLC----LPGRHVDMLPNADRLPVQ-APLSTSQSVSNKN
TTAS-QVPWAL---LWKGGDS--PGQ-R-EPGNPKAKAPQKS--QKTLGSADKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------PGTSEASGRSHSAHTREIGDKQERKYNQPQP-EKGETPPES--HFRRKIGHH
PRGLH-PRKTGA-RWEDVLEKGKPGA--DAV---------Q-SWGSGPAR-LF-MD----
CMVDEA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENYLFSL-----KSITAG
---WLSFS---PTSWTIKAIFIFLCILGVYTVYCIYFFLLFSYFR-NDPSLPPH------
------------------KKHRSSRKHRVEPQRRSSRS--QKKAQTLK------------
----------------------------------------------TL----KAC--RDC
LQE-------LE-EVQDLIS-LLQ------------------------------------
---------SYLGR---LPDQG-AF--------------------HHLLHQEAPEEVSKA
APA-R------THKPRK--ES-GENAAH-TLA------P-SASPA PL----H--------
--------------------------RLLPLDSTLPAE-PQEDQ-------NNLKK----
------------------------------------------------------------
---------------------------------------------------------ILL
----------GTIT-----KSLLPGN----SSLASL--ILAVSGLR-HA-DYPILS----
--------FS-WWWESTK---SL---FFPT-----SSQHKCQQEHL--ACHP-PEASFW-
GDPTNWQIETH--K-PSFVTS-DVQKLL-EILI-T------KR-------VELKIWK-E-
KE--KDGSIGKQLC-----------------PDNH-LNS-L--G-----TMWKLLSAEQT
TITP-------QSFRNQKDE----------------------PE---QLASP QQLSSPKI
LE-DHLQQKCSQLFWGLPS-LHSESLLATAL-VCTHSPQL--QVPFLLFNGLSN------
----------CLPALIQVFISSQFSHV----SSLP---------HHGIQ-LQPSTPIWPQ
--PQAH------------L-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------A-----PSVPIRPPSLP--
-PQMS-----ACGVPCPAS-QEKTQFFIPNET----------------------------
--------------------QQLEWPL------LPKHQE---RGRTLHYMMKRYRKFFGK
VPPKLPKYNQ-----DSQSYGSVSII--HG-DFVIFNIQKHHHQ--RRLS-KDKHR---D
SL-PHRV-QVSLELMWPPNEF-------------------PETSKA-Q--DNQG-----F
S-R----------------PFVFKGKSSQTTQR---TKSRD-PRSFYRKSQTRSQL---Q
--NNL--GNGLQQCLKRS---------PTDLSR----VS-ASFPV-KVLGT-DSEEELER
HLMRTL--------KSDQGKH----LARGPGK-KHLEKNLEVHLCR-KLGQINEGLIP-V
SVRRSWFMAT---HSL--P---KSHLGSERR-NLASLNDRK------PCINTSHELPFLS
PHTRQMLEAHIIRFRVRHKWDLP-SQAFEPIDLK---------LCEAQPLPLPLHPSPCS
ATC---VSGTHSRAMF--------------------------------------------
----------------------------YKFLGKPPQPHLGE-EITEESI--P-TSESPQ
-PVPSSASEEIQQ-A---------SPGDVQEPSE-VPLPGQEDRSPS--QTSTLSLTNRA
LESE---IVMGAKKDN--LES--SS--ATARNELKDKSGDQ---ASQNKVA-ILK-----
-----MKLRSQFTR----AEEAREETEPK--K--APAWKVILKPSMLANNQT-IYVDLR-
RSGSPCPS-KSP-LPPTELAAQDLKEPCLKAKVASKFELQEKVESENQPQGPIAGVPLQD
SSSDISLQDSGTCDLVQDHDTKVP----LQDSPTDVLLTIDTLSTHKSSSCSQREHASGD
TPAS-PVPHDL---VSSELSS--EVQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------QEPSIPKAEDPCKSQSE
MTISTAETEDLQSPKSEEH-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
ECAEP-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LGSSVFQAGGTGHPPRVRGTGDSLGSKYLQLMP-ERGQVIPES--HFRKRVRNF
LQCLN-LNKKGK-GLEDPLQKGKPVS--ATV---------Q-REVPVRSR-SV-MD----
SRATEAQTIVTAVGRVLVEKLGLYQGMR--------------ASDINMHKE----FQAPG
RG--HS-RH--HKVLSSPEQGRVMRETASKQQAIPKG-HSCPNRAEWIPGRDSRW-----
------------------------EGPPRELGA-PGRP-----SQHRLMLA--GASG--H
IH--RY--P--TYSLQKCVSSHQAVCAPHTCHGRKA-LLQEKVEYMQRKPFVSHVSTSSM
C

-----------------------------------------MENLPFPL-----KLLSAS
---SLNTP--SFTPWVLDIFLTLVFALGF-------FFLLLPYFSYLRCDNPP-------
S------------PSPRKRKRHLVSQCPVGRRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--LVP
P--------------------VSC------------------------------------
---------SLLGP---HLAKG-DF--------------------GQLSGPDPPGEVGKR
TPD-G------ASRSS---HEPMEDAAP-I-------VSPLASPD PR----TK-------
--------------------------HPQDLASTPPPG-PMTTSV------SSLSAS--Q
PPEPS---------LLLERP-----SPEPPVLFPHPPHTPD---PLACS--PPPPKGFTA
PPLW--D--------------------------------------------STLLTPSHC
DS-VA--LPLDTVP-----QSLSPRE-----DLAAS--VPAISGLG-GS -NSQVSA----
--------FS-GSQETTK---TWC-----------VFNSSVQQDHL--SR----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QRDTTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPALP--
-SPMR-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPERPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQERL------------TSIL--PENFPVSPELWRQLEQH--------------M
GQ-RGRI-QEPLDLMQLQDEL-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAET---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
NLR--------KPLRSDSGSD----LLRRTER-NHIENILKAHLSR-KLGQTNEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAVPKTRK------ACVNTAQVLSFLE
PCTQQVLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------QLEKVSSLSLIQLAGPSS
DTYT-CESGAGSKVEV--------------------------------------------
----------------------------ATFLGEPPMASLRKQVLTKPSVHMPE----RL
-QASSPACKQFQR-APR-----GIPSWNDHGSLK-APTAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AVPQPTVPLGTCMRANLQA-TSEDVR-
GFKAPGTS-KSS-LLPRMSVSQDPRKLCLMEEPVSEFEPGMATKSETQPQVSAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QGHLQSMPTGN
MQAS-QELCDL---MSARRSN--VGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSP--MFPPTHKR-------ENSRKPNLEK
HEEMF-QGLRTPQLTP------GRKTEDTRQNEGVQLPP-SKKQPPSIS--HFGENIKQF
FQRIF-SKKERK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
GSSAEAERLTTAVGQILEEKMSLCHARH--------------ASKVNQQRQ---QFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKN-QSRPNRDRQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PFSP-----PQHRPKTP--GASS---
-HHHHR--PRQCLFQGR-I-----------------------------------------
-

-------------------------------------MIQRKENPPLSL-----KSTFDT
---WLNSS---SPFWAIDTILAFLCGLGL-------FFLILPYLE-NNPSFPPL------
------------------RKHGNIRKHQMERRGRSRSS------KRNG------------
----------------------------------------------AL----KAC--RDC
LEA-------LE-EVWDLTS-LLQ------------------------------------
---------RHLGR---FPDKG-SF--------------------HQVSCQDSPGEVCKA
VSA-G------AHQPCR--EE-A--------A------P-TISPA PL----TK-------
--------------------------QPLPWASTISPG-S----VSTYS-ESYLSAS--P
TPEHL---------FPLDSL-----SPWPLALSPSPPRPPH---GRAY---SLPPAPCSA
PKPS-----------------------------------------------GSMMSLTQG
DS-TA--LALGTIQ-----HRSSPHSPWR----------AAISGIV-CS-SSPGSA----
--------LA-WWQEAAK---AW---SFST-----LTHLESQKESL--PLSP-PEASFL-
GDPRNRQVEAG--S-LAFINP-DVQELL-EILI-T------KR-------VELKFWK-E-
KE--KE-E-----------------------AGYH-RNS-S--G-----KRIESLGHKQD
TLSH-------HHFWNIKGK----------------------RE---QLLGPE KPRYPDT
LG-DCLQKTCSQLFWGLPF-LHSESLVAAVT-LPGSALEL----CPVLFDEHSK------
----------AKPFHLPAKVTSKLSLA----KHLT---------HPVTQ-AQPQSLTPTM
PQLQPS-HLGHMETQAQPLPLTPIIPQCQP SSEVSMETQSSAQILASTMPHSQPPTWAHM
KTQVPPLLQAPSMSQCQPPQPQAHVEIQDQSLPSTTNMPQFQPPPPTHMETQVQSQLLAQ
TMPHIQVPLQAHMETQVPPLLQTPSMSQYQPPQPRTHMETRVQSQLLAQTMPQFQAPLRA
HMETEVPPLLWTPSMSQCQPPQPQAHMETQVQHLRWTPNMPQFQPPVWAHMKTQAQPLPW
RGRGQATMPQCPPTSKISMEVQDHQQPSTPTMPQFQPPPWAHMEIEAQPIPLNLNIP LCQ
PSSRAHMEIQARPQSLTPVIPLYH----PRPQAQFETTVHPS-----PSRLVQSSSSQ--
-HQIG-----STETSCPTV-QNKASSFSSNAI----------------------------
--------------------ENLESHF------RKKQLE---RERTLPSLVTNSQQVFSQ
VTPNLPQETR-----SSQAHRSVSVL--PG-YLISPEVREKLEHHISQRFMQQ--Q---S
GL-PYRI-QASQKLMQPQDQY-------------------PRPCQA-Q--GREG-----P
S-R----------------CSAGLGKRRQDAQK---MRSKC-PAQ--------IVP---G
--RDL--HHDVGQSVGKI---------AKHLYM----FS-ANPPV-EDPRA-KSE--SE-
-------------------------RVLSPDK-KHPAVSS-VLTER-KGKQICEREIL-V
KVYHSRLAGN---LVL--DILGEANGPMKTE-STQSSQDGK------ASMITSHESLALT
PYTEQELEAHIIRFRVRHRWSLL-FKVLKFIFCL--------KLKKV-------QGPTLK
ATC---ESGDHSA-LL--------------------------------------------
----------------------------TKGLGKPPQPHTGEKLITTEAV--A-PLENPL
-PVPSWATKKTCG-YLG-----GPTPGDTHKPSD-VCLTGQENKPSS--PAPKYNFVSRM
WHSE---SVVETEK-G-GLEPS--PSSAMARSEPQKKTRGQASPESCSNVI-VVD-----
-----LDECSPSPR----AQE-----VVE--G--DSAGKGTREPGVQVKSLD-INMDFR-
RLRSPRSN-KSP-SLNTKSVASNTEDLLFETQF-LKLESQRFTDQQDHAQGQATSVLL--
-------QDCETGVLLQDCSSDTL----LKDCHSNMFLAANMLASQES-LSY-QILSSVD
KSNS-QKLYDA---TSSEGSS--QGQ-Q-VDMR--RQLKY--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQGK--KSVPKDGR-------EKYTRPKLRQ
IQKGL-AERRAYQPQGMSHPGQKKESTESLKSKFRQLIL-KKRPVPSES--YFKERIKLL
LQWIF-PNK-CK-EPEEPLQKGKLET--VSV---------K-SQESIKSK-ST-MD----
SRAVEAQTVITAVGQILKEKMVFHHGPH--------------ATELNWYQA---DFQDPT
CP--HY-CH--HRILSYQEQRRMRRDTPCYHQAIPMC-HSFSNRSKWTSSRDSKW-----
------------------------AFSPRDPGPPPGRA-----CQLGSRVT--SIPG--H
PL--HC--PRHG-LLQKYVFL---------------------------------------
-

------------------------------------------------------------
-------------------------------------------FSYLRCDDPP-------
SPSP------------------GKRKCPVQWRGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--REC
PRG-------LE-ETWDLLS-HLQ------------------------------------
---------SLLGP---HLDKG-GL--------------------SQLSGPDLPGEVGRR
APD-G------ASQSS---HEPMEDAAP-I-------LSPVASPD PR----AK-------
--------------------------HPQDLASTPSSG-PRTTSV------SSLSAS--Q
PPEPS---------LPLEQP-----SPEPPALFPHPPHTPD---PLACS--PPPLKGFPG
PPLW--R--------------------------------------------STLMTPSPE
---GA--LPLGTVP-----QSLSPHG-----DLAAS--VPAIAGLD-GS-VSRVSA----
--------SS-WWQETTR---TWC-----------TFNSSVQKDHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQHAV-GIQV-T------ER-------TKVNIWK-E-
KE--NDGSFTDQMT-----------------PEKH-LNS-L--G-----NLVK-LDAEQD
ATTP-------KPFWNMGEN----------------------SK---QLPSL QKLSDPRL
LQ-EGFRKHYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSS------
----------VSPVQRDTTLSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-PLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDICSV
PTPNLPQESL------------TSIL--PENFPVSPELQRQLEQHIKKWIIRH------W
GN-LGRI-QESPDLMQLGDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
QKKDP--CPHLGQILGQT---------PQNLSR----GM-ESFPG-KVLQA-TSE-ESER
ILR--------KPLRSDSGSD----LLRCTER-NRIENLLKAHIGR-RLSQTNEGLVP-L
TVRRSWLAAN---QAF-----PVPNTHVKTS-NLAAPESGK------ACVNTAQVLSFLE
PCAQQVLGAHIVRLRAKHRWGLP-LTVLKPIRCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATSLRKPPMASLRKQVLTKASVHMPE----SL
-LASSPACEQFPM-VPR-----GMPSWNGHGPLK-APSAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRQ---------AVPQPRVPLGTCRLANLQA-TSEDVR-
GFEAPGTS-KSS-LLPTVSVSQDPRKLCLREEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHPSENLASQVP-QGHLQSMPTGN
MGAS-LELRDF---TAARRSN--LGH-K-EI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ESQSA--MFPSTHKS-------ENSRNPYEEK
HEEGL-EGLRTPQVTP------VRKTEDTHQDAGIQLLP-SKKQPPSVS--HFGENIKKF
FQWAF-SKKKSK-----------PAP--VTA---------E-SQKTVKKRSRV--Y----
SSSAEAQELMTAVGHILEEKMSLCHAHH--------------ASKVNQHKR---EFQAPV
CGVPCN-----HRHLFYSEHSRMLSYAASSQQATLKS-QGCPNRERQIRDQQ--PLKSVR
CKNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHQPKTP--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

--------------------------MPRAQLLEGS-IPIQMENIPFPL-----KFLSDS
---WINTP--SSTPWVLDIFLTLVFAGGF-------FFLLLPYLSYFLCDPPSPSP----
---------------------GKKRMCRGQRRGRPKGR------KKN-------------
---------------------------------------------NSL----KGK--LVP
-------------------P-VSC------------------------------------
---------SILGP---HPKKGKDF--------------------GQLFGPDPPDEECKR
APD-G------ASQSP---QEPMEDTAP-V-------LSPLASPD PQ----TQ-------
--------------------------HPSPLGSTPSPS-PVATSV------SPLSAS--Q
PPEPS---------LPLEHP-----SPEPLAVFPNPPHTPD---PLAGS--LPPPKGVIA
PPLR--D--------------------------------------------STLTTPSHC
DS-VA--LPLGTIH-----QSSSPCE-----DLATS--GPAISGLG-GS-SSHVSV----
--------SAFWCQETTR---TWC-----------IFNSSVQQDHL--SCHP-PE-----
----TSRMEAG--S-PFLLSS-DGQNVV-GIQV-T------ER-------ARINVWE-E-
KE--KDGSFPKQMN-----------------TEKR-LNS-L--G-----NWVKSLDAEQD
TTTL-------KPVWNME-D----------------------LT---QSSSP QKLSDPRI
LK-EHFQKNYSQLFWGLPS-LHSESLVANAW-VSERSYTL--QSPPFLFNGIPN------
----------VRPVQTETIISPLLFQA----QHLS---------HLRPE-SQPFISP---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFQ----LSPMAQAQAQARLQ-----SSFPVQSPAFA--
-SPIN-----NSGVACPAS-QNKAQALTLPEM----------------------------
--------------------QCPEWS--------SKQLE---GGLALPSRAQKPQDVFSI
STPNLPQDSL------------TAIV--PESFPVSPELRRQLEQHIQK------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------C-NLAPLKSGR------AGVNTSQELSFLH
PCTQQVLGHHIVRFWAKHKWSLP-LRVLRPIKLF--------KLEKVSSLSLTQLAGRSS
ATY---KSKSSSKVEK--------------------------------------------
----------------------------AVFLRESPPADLRKQVLTKASVQTPD----SL
-LVSSPTFTQFQM-APQ-----GIPSWNPHGPLK-PPPAGQEGRWPS--KPLTCSLTGSA
QQSG---SV---------------------------------------------------
--------GAQSSR----TGETME---------AAPQPSVPLGTFLPANLQG-TRKDVS-
GLEAPGTS-KGS-QLPGMSVSHDPEELYLMGEVVSEFEPRMATKSETQSQVCGAVVLLPD
GF------------------------------TD-IPLATESLASQVP-HGRLQSMPTRN
MRAS-QELRDL---MAARRSN--LGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPKCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQNQ--MFTPTHKT-------ENPVKPNFEK
REERL-EELRTPQRTP------ATKTEETRQDEGLQLLP-SKKQPPSIS--NFGKDIKQF
FQRVF-SVKKSK-----------PAP--VTA---------K-SQKTVKNKSHV--Y----
SSCAEAEGLRTAVGQMLEEKMTLCREHH--------------ALKVNQHKQ---EFQAPV
CGLPCS-----HRHLFHPEHSRTLGYAASSQQATLKS-QSYPNRERHIRDQQ--PLKSVR
CNNEQWGRR-HPQ-----------PLLPKNPVS-PVSA-----PQGGLKTP--GAFG---
-HHPHC--PKHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSPS
---SLNTP--SSTPWVLDIFLTLVIALGF-------F-LLLPYLSYLHCDDPPSPS----
---------------PRKRKCHLVSQCPVGQRGMPRGR------MKN-------------
---------------------------------------------HSL----Q----REC
PRG-------LE-ETWDLLS-QLQ------------------------------------
---------SLLGP---HLAKG-DF--------------------GQLSGPDPPGEVGKR
TPD-G------ASRSS---HEPMEDAAP-I-------VSPLASPD PR----TK-------
--------------------------HPQDLASTPLPA-PMTTSV------SSLSAS--Q
PPEPS---------LLLERP-----SPEPPVLFPHPPHTPD---PLACS--PPPPKGFPA
PPLR--D--------------------------------------------STLITPSNC
DS-VA--FPLDTVP-----QSLSPRE-----DLVAS--VPAVSGLG-GS-NSQVSA----
--------FS-GSQETTR---TWC-----------DFNSSVQQDHL--SR----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------QRDTTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPMK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPPRVQKSQDIFSV
STPNLPQERG------------HPFL--VHSTPG--------------------------
-Q-DSRV-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------SG-------SDA
GHR--------KLPR ED-----------SGDR-NHIENILKAHMGK-RLGQA-KGLIP-V
SMHRSWLAVN---QAL-----PVSNTHMKTS-NLAPPKSGK------ACVNTAQVLSFLEQCTQQVLGAHILRFWAKHRWGLP-LRVLKPIQCF--------KL--VSSLCNTQHAGPSSA--T-CESGAGSKVEV------------------------------------------------------------------------ATFLRKPPMASLRKQVLTKASVHMPE----RL-QASSPACKQFQR-APR-----GIPSWNDHGSLK-APTAGQEGRWPS--KPLT--------QSR---SL-----------------------------------------------------------GAQSSR----AGETRE---------AVPQPRVPLATCMLANLQA-TSEDVH-GFEAPGAS-KSS-LLPRMSASQDPRKLCLREEVVSEFEPGMAMKSETQPQVSAAVVLLPDGQ------------------------------ASVVPHASENLASQVP-QSHLQSMPTGNMQAS-QELHDL---TAARRSN--PGH-K-EP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNPNCQGSC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSQRP--MFPPTHKR-------ENPRKPNLDKHEEMF-QGLRTPQLTP------GRKTEDTHQNEGVQLLP-SKKQPPSIS--HFGENIKQFFQRFL-SEKKSK-----------PAP--VTA---------E-SQKPQLDRYWR--R-------------------------KYHFAMR--------------AMPRNQHQQ---QFQAPVCGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPIRDREI-DQQ--TLKSVRCNNEGLHCP-SFC-----------QHFNHNCLT-SL--------YNGPNFP--SSSCLLPSPPNSP--PSGED-----------SGDR-NHIENILKAHMGK-RLGQA-KGLIP-VSMHRSWLAVN---QAL-----PVSNTHMKTS-NLAPPKSGK------ACVNTAQVLSFLE
QCTQQVLGAHILRFWAKHRWGLP-LRVLKPIQCF--------KL--VSSLCNTQHAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLRKPPMASLRKQVLTKASVHMPE----RL
-QASSPACKQFQR-APR-----GIPSWNDHGSLK-APTAGQEGRWPS--KPLT-------
-QSR---SL---------------------------------------------------
--------GAQSSR----AGETRE---------AVPQPRVPLATCMLANLQA-TSEDVH-
GFEAPGAS-KSS-LLPRMSASQDPRKLCLREEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QSHLQSMPTGN
MQAS-QELHDL---TAARRSN--PGH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------QSQRP--MFPPTHKR-------ENPRKPNLDK
HEEMF-QGLRTPQLTP------GRKTEDTHQNEGVQLLP-SKKQPPSIS--HFGENIKQF
FQRFL-SEKKSK-----------PAP--VTA---------E-SQKPQLDRYWR--R----
---------------------KYHFAMR--------------AMPRNQHQQ---QFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPIRDREI-DQQ--TLKSVR
CNNEGLHCP-SFC-----------QHFNHNCLT-SL--------YNGPNFP--SSSCLLP
SPPNSP--PSGC------------------------------------------------
-

-----------------------------------------MENILSFL-----NRYIEP
---WLDFG---LAFLDTDPNYIFLSGVGF-------ILLYLWYLI-LKPFLPPP------
------------------WKSQDIKKWQGTSGKDKGKR----------------------
---------------------------------------------RSF----KGC--RTT
---QR--R--TQ-EWRKL------------------------------------------
----LSVVQSPLGD---LYDPS-HF--------------------RQLLCPDPFCDVCNG
ATA-K------ISRL-LSQAT-LEDGA--ASVSS---MDS--T TVSV----TE---TSLT
LSLSLPENPLGHPISDPPYEPSL------HSSSIISPH-QSAHLEDTLF-ASPLGDS--V
LSESIPP---VNAKFSLDHD-----SLHPFTTFPLPQ-HAT---QETEL-LPQPATILSL
VGSP----------RELFT-IPTNKGI-CNSRHAMSE-----------------------
------------------------------------------------------------
---------F-TQQQTDI---DN---SFQL-----EPAHLVNQELL--DLHS-SESYLW-
GNITTCLTLPG--N-LPLSSP-DAMVLL-ERQD-G------KM-------SDSF------
-------------------------------------KT-L--G-----KTPD--SDQQN
LAVP-------HPLGSCKGK----------------------LE---RLHMY QQSPHLRT
SE-DQLEPQHIQFFWSLPS-PHSKSMNSIAT-VWADSSL-----TSECFN----------
----------------RFSDSPVLTNH----TPLS---------LPESQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLPQTLSPSQ----SQPVPPAKPQAQLQ-----HSVPVLSPSHL--
-SQLR-----ICGVYFHRP-QDKVQPLDPSAI----------------------------
--------------------HCLEYNI------LKKEQE---RVWGLPTVVKKSQEEFCP
PPPKSSLVKQ-----SSKIHVPRSIS--LGNFLLTSELRKKLEHHLRKRLILQR-----W
GL-PKRV-HKSLSWMSPRAEL-------------------PESSSS-T--SNYG----LS
W------------------ISFFKQQDSKNLHN---IVLNE-PGSFPARQS--------R
-EKLL--KAR-RNSLETV--------QKHQLWS----NT-KGALA-NGLQS-DCETNLQC
H--------PGSLSGKPSG-----TSEVSQCQ-KKLETALQKHLIS-HLNETNEGHIS-G
TVSRLGHCPL----------PYTLG------------IDKE------EHEAQ-----RQL
PSDN--KDGHVKSTY---------------------------------------------
---------------------------------TM----T-----KSVLHQA--------
------------------------------------------------------------
-----------------------------------------------------SIGLDNI
RLKE---S-E-GNRHSPDVP----RISTEA----VGKQLDFSKTVQEPQGTQMNDE---N
IFVSNKV-----------S----NIVKRGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MEKILSAL-----NGLTET
---WLTLG---SASYHIDLNYTLLSGLGL-------LLLYILYLI-LKLLIHLL------
------------------WREKYTPKLWEKG---KKRR----------------------
---------------------------------------------QTL----TGG--PAC
---QR--E--AE-QRREL------------------------------------------
----RTTQPSSLEE---PSEAS-SN--------------------ELPLHRDPLLPVCDR
S-G-D------VGHQ-LSQDH-LKDGK--ASHLC---V---ASTVPG----TE---ASFV
LSSLLTGNQAGHSAPALPQEPLP------LAPSILSPN-CFAPLEGFYS-STLLHDS--L
TPESTLP---LNPPLLLDPT-----PPYPLASFPLPT-REA---QKSEV-VVQLETTRSL
VDRL----------NEMPTNVPPAQGT-GCVRQTMPE-----------------------
------------------------------------------------------------
---------A-SQEQPAA---DN---QLSS-----DSKN---QYLP--APRV-PQVPLQ-
GNTRAYHVEPG--Y-LFFPNS-NAVKLS-QRLD-K------KV-------SDFLMVK-GE
QE--EW------------------------EEEEE-EED-K--G-----CFIKSPSSSEK
LLSGETLGEPQDLVASHSSS----------------------SK---GKLTHQPLPHSKT
FE-DHEELQPSLLFWGPPS-LHSETLSPTTT-NAYDRSS-----ALVCFN----------
----------SMAEASIADYSHGCMLP----TPLH---------AY--R-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TWLQTTPQSH----PQRDPPAELQPQPQPQPQSRVSVLTF-SRQ--
-SELR-----DCGVHFHRP-QGDEQPLSPSEM----------------------------
--------------------QCLEYNI------LKKEQE---RVWGLPLVVKKSQDTFCP
SPPKVLLGSR-----SSKACTPRPIL--PGDFPLTSELEKKLEHHLRKRLIQHR-----W
GL-PDRI-DKSLSLLSPQSEL-------------------IDFSES-Q--KNQG----LS
W------------------ITFFKYQGNKDSQV---LSGGS----SRSWMPKRHSL---R
-ETRV--KER-TYSQDQG--------HKDQSRG----NNFQEASQ-NSVQS-HLKTHWKS
R--------TGRQPPKFSS-----PSQVKQYQ-RGIEKALEKHLNK-KIREISRGEIP-I
TVNRSRHSVNMANIAQ--PPPESSPKRM--K-DQAPLAYKE------HVLTRHPHSLALS
PSKEKMLEQHITAFRRRMAFGLP-QRVEESLESY--------STKAEPSQPFPQLHVQAH
NVSR-ADPAKSSRSL--------RRNTTGDRMGTV----N-----SVPTQQK--------
----------------------------------------------------------PL
PAA-SLVGHSQPASEN------------KVCVDR-DLSVALRGREPT--QHWAPRRADKG
DVPQ---SGS-HNKPGPELP----MSPD----VPALKCQGLSPAAQDRGRQHL-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MEKVLSILNSSILTSAKES
---WLSIG---SVFVDIYPKCIILSVLGM-------LFLSLRYLI-LKPVLP-T------
------------------QTSQGVRKQQGRA--KRERR----------------------
---------------------------------------------TSF----NEF--RNV
---HA--E--AR-EWRKL------------------------------------------
----QAVVQSPCGQ---LYDPS-YF--------------------RQALCQDPCCDVCNG
ATV-K------VRRL-LSWAS-LEDCS--ASASS---MASMD STASV----TE---ASFT
LSSSLSPSPSGYQLSSFSVASSP------PPPSILSTS-TLTPLED-----TPQGDS--L
PPEPTLT----STGCPLDHL-----LPHPLPKSPSMAHPGT---QQTEGPLRPED-ILSL
AGSH----------GDRFLHATTTCDA-LP------G-----------------------
------------------------------------------------------------
---------S-YQQQPGA---QN---SSPS-----QLKCFVNQEIP--NHHS--SEDFWR
EQASPHFTVPQ-----------KVLKIL-ERQE-E------SQ-------ADVLTLK-DG
EG--EAEP----------------------------------------------TAELQN
LGAS-------FPLEGSSII----------------------LS---ELNPQ QGLAQVQS
SG-GQLEAMPMQHFWGLPY-LHSESVSCITT-LSSHCSS-----MCIWFN----------
----------------RTTDSPALAPP----SPLP---------LPERQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------TLTQSQ----SQSIQLATPHSQLQ-----T-LPGPSPSSQ--
-SQVR-----VCGVYFRRS-Q-EAKALLQSEI----------------------------
--------------------HHVEYNM------MAKEPE---REWALPSVVQKPQEELRL
LPSKLSLAIK-----SSKLQTPRSVP--PRDFPLADGFQKKFEQHLRKRLILQR-----W
GL-PQGI-YKSQLWANPDPP-----------------------EAS-K--SSSG----LS
D---------------------FKHKDNKARPN---TVSNQ-SGSPQEK---SVSI---E
-RKIV--KAH-EQTLEII--------QK-YICS----NS-KTAVD-NGLPS-DHEINLQS
H--------LGSLSDQPSE-----TSQVSQCR-KKFETPPKEHLKS-HIDGTNEGQVP-I
TMSGLKHCPL----------HFKPC------------VGKE------EKQTE-----RQS
PSDI--KDEDIKSEH---------------------------------------------
---------------------------------RI----T-----VSGVQQT--------
------------------------------------------------------------
-----------------------------------------------------SVVFDTT
ILEE---S-E-AKRPSPDVP----KMLAKAGPMPVGKSLSSSKIVQGPQGTKIDDK---H
VFVSNKV-----------S----NIVK-EQLGGLQPRPTKISKASQCKSAKD-GDGNTP-
STQS-TQL-AGR-APEGISGPPNIRASDFSCQVTREEKSESENSQPIQASEPPK------
----------------------------------VVFPVSDKLTHTP-LPIHDQMPSSAP
TNAA-QVQ-------------------PQEPEMPAH--PLG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGLNK--DS-PQSAKR------SWPA-WKIEE
LGSGV-AGPEKLQPSGKSHRAQDSPTPGNHGKRPIPPSPPVKALSPPEH--QFRKHVKHF
FQWLS-PDRKCK-GQEALLKRDASPP--SPA---------HD-LE-LKGRATF-------
PGNTVAQKALRDFGKVPKEQPGHRHGAADTMRPRVPVSPPTKPV-KAKPKREYCVPTDPV
QGR-QL-H---PPAPVSK----VSSPRFHNQDAAFVD-QKR-----CMAERARQPQKCEA
LQP-------R------------PSASHRESELRQ-NLLWNRAGKVPQGTP-PFAVG--T
MLADMSRLCEQKILAQN--FRG------KAFVPQK-------------------------
-

------------------------------------------------------------
--------------------------------------------------SPSL------
------------------SLSFFCSQHQGRARRR---RKGG-------------------
----------------------------------------------TF----KDR--KCF
QRE-------VE-EERKLLP-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-HF--------------------RRLLCPDPDCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSTPSATPTEDLILSPRPKLSP------PPQLILSPD-LITSLADLFS-PSSLRDP--L
PPQPVSP---LDSKFPVDHS-----SPLRLPFP-LLPPPHI---QRAEP-SLQPEANFCL
NTTFSLDSTQCQD------ISQAMNPTDSCAHHYKPPIP-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPCAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEVSLG-
GHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----KMLSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QEPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPPVL-VQRGCSS-----MFVFFNGITN------
----------TSLF----QESPVLPPP----QA------------------L--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SLPQTLPQGQ----SPHLTQVQSQSQHQ-----SPLPALLPSPP--
-FLIK-----ICGVCFHRP-QNEARSLTPSEI----------------------------
--------------------NHLECNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNLTLVRK-----SFKVHVPIAII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------LELSMS-E--SIQG----PL
H------------------SSSVEGQSLNVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DP-ETSSD-ENPRS-NSERDLNT
H--------MMHLSGNHS--------GESLGQ-KQLEDALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVNED------HCVETSQEISFLS
SNKQKMLEAHIKSFRMRMLWGLP-RKVLESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISRD-SKVDVSKSRRRS--SFQGEKWGTT---------NSVPVLDGPHPVTSPV
SKEGQDTLRRQYSDTDHDFIGSDSKDGASTLLRRDITDFQGEILESTNSL--P-ILGHSP
-LLTSPVDQEKQG-TLR-----REFADTDNDLTE-SVATTEDGRQTF--LPPTHSVIDEV
SQKQ---TVP-ASRCSAEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRET------
FP---------------------------EICALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DTSIAFENLSSKDL-LTHPQGISSRD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPAAVKT-------VSPMRPKGGE
LGGGD-AGLGTSQLRRKSHAIHDKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWLKTF
LQRFNKPSIAYT-EQESSRAKGSSLS--SSV---------QN-RGRVTRRAAF-------
IGTTEGQKIRKDTRDSLEEKLGHRRGIDV-TCPQEPLSFPVEL-GKAQHNPDVQVRAEPV
LGYPCN-----YTAPSCK----VTCTKSYSQQAIFVG-QNYPTRIRQITDKDRQSEKVEA
FKGKILCQR-HPQ-----------SI------------------LVCPAVL-TSAKS--S
VFSDVPLLTRQKMLPKH--FQG------GKFPPTK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
-------------------------------RRRK---KGG-------------------
-------------------------------------------------TF-KDW--ITL
QKE-------AE-EERKPVS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ILRRDP--L
PQKPV SP---LDSKFSIDHS-----PPQQLPFP-LLPPHHI---QRAEP-NLQPEASLSL
NTSFSLDSTLLQDTN------SAMNLCDSCTFHYKRPNS-SALRM-QD----C--TVTQS
KAS-------LNILKPLEKEMVSVGGS---GGSTAS--SSTIRDID-HS-CPASAE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMQELL--SLHS-SESFLG-
EYSVVNLTVPV--N-LSFLSH-DIVALL-ERQV-K------KR-------ADFLMCK-ES
GK--TPGTFPKHLR-----------------PNYQ-PNS-S--G-----KMSASIAVKHG
LATS-------FPFLASNRK----------------------VE---WLHTH QQPPYSKC
FE-DHLEQKYVQLFSGLPS-LHSKSLNPTVL-LPRGRSS-----MSVSFNEIAS------
----------MSAL----QKSPVLPHP----QSLS---------LPITQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLLQGQ----SV--------AQHL-----SPLTAQVPSPPLL
DLQIG-----ICRVCFHKY-QNEALSLTPSEI----------------------------
--------------------NHLERNV------LQKVLE---SVWGLPSVVQKSQEYFCS
PAPRLALV-K-----PFKACGPISII--PGDFALSAEVRKKLEHHLKKRLIQHR-----W
GL-PRRV-HECLTLLRPQSLI-------------------SE---S-E--NSEG-----------------------------------------------------------------------------------------------------------------------PESDLEGR--------MMHLPGNDS--------GVRLGQ-KQLANALAVHLSK-KSEEINGGRVP-ESVRSSWHSVK---QTM--SLSEKSHSQINHR-NLAAPVGED------HCVDTSQEMPFLGSNKQKMLEAHIKSFRM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSEG------
------------------------------------------------------------
-----------------------------------------------------PESDLEG
R--------MMHLPGNDS--------GVRLGQ-KQLANALAVHLSK-KSEEINGGRVP-E
SVRSSWHSVK---QTM--SLSEKSHSQINHR-NLAAPVGED------HCVDTSQEMPFLG
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MEKILSAL-----NGLTET
---WLTLG---SASYHIDLNYTLLSGLGL-------LLLYILYLI-LKLLIHLL------
------------------WREKYTPKRQTSI--RRKQR----------------------
---------------------------------------------KAF----KRR--KAG
---PR--D--PE-EGRRL------------------------------------------
----QTVLQ-SPDK---PYDPT-GF--------------------RQLLCPDPHCRVCNK
AST-Q------VRHL-FSQVP-LEDGA--ASVSS---L---PSTA PL----TEASEASLA
LPPHFPANQPGHPAPETPPR---------TSLSIHLQN-QITPLDGVS-PPISLSAS--L
SPQAAAS---LNPAVLPAHT-----PRRTLASFPHLHPNTT---QEAQL-ALQAEVPKPP
VESP----------RERPPSVSTAKST-IYEP----A-----------------------
------------------------------------------------------------
---------S-SRPQFSA---ED---QSLT-----NSTHVINHQPPPSDSYA-SQGSYQ-
GLTKAYAVEPG--D-CLSPSP-DVLALF-TKQA-E------GD-------ADGTVYK-LK
RE--KAISFLT-----------------------P-SNT-S--G-----EISASTAGLEN
LEVS-------HLLGNEKGK----------------------PE---DPHLL QQPSHLKN
SE-GQSEIKDIQLFWGLPS-LHSESLKHEAA-NTGNSYP-----GRDYFN----------
----------KVAQASTGSHSSNLTYL----IPLP---------LPESD-QQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GQI--VPQSQ----IMPDSLANSKAQPQ-----SLAQFLPPSPQ--
-SQLG-----ICGVRLHSL-KNEAQPLTPCEI----------------------------
--------------------QQLEYNL------LQKALQ---SFLGLPTLAEKFQESFCP
PPPKISSTRN-----SSKVHAPKTIL--PGDFPLSHTLERKLEHHLRKRLIQRH-----W
GL-PHRI-LESLSFLSPHSEI-------------------PEAPKP-R--DTHG----LS
W------------------VSPYKFNANTNLPS---SGVSQ-SGRSCKKPLESHPP---Q
-EKDI--NIQ-RHRPGIN--------QKDPIQC----KS-CGATK-STVHS-NSETDPEL
Q--------LGNTSGNISK-----ASWVKQCQ-KECETFLQKRLGK-NTKEISGSEMP-S
AVDSSRHSRD---MTQ--PPPETCPRQM------APLACEE------DSRTRHPHSLEIS
PSKEKTLEEHITAFRRRMAFGLP-KRVEESLESD--------LTKAEPSQPFPQLHVQAH
KVSG-ADSAKSSWSL--------RRNTTGDRMGTV----N-----SVPTQQK--------
----------------------------------------------------------PL
PAA-SLVGHSQPASENK-----------KVGVER-DLSVAPRGKEQT--QHRTPRRADKG
DVQQ---SGS-HNRPSPEMP----MSPG----RPTHERLASSTNTQGSQEERRSWE---D
SSKAEGS-----------T----ELHKGEQLPGLHPQSTKSLKGTQDLCSPG-S------
-----PVT-ACQ-SPQGMTISHNSESPDSKSQVSTEVQPNSEGRTHNQVPDLPA------
----------------------------------TPFA-PQEMT------SKPQGPSGGD
MAVS-QVLHVH---MPSVGIS--MEK-S--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

---------------------------------------MEKKFLLFPP-----KSTFDT
---WLNSS---YTAWRIEIILAVLCGLGL-------FFLFLPYHQ-NNPSFPHP------
------------------RKRGHSRKHQKDLRGRSRSR------KRSR------------
----------------------------------------------AV----KVC--RDC
LEE-------LE-GIRNLVL-LLQ------------------------------------
---------SHVGS---LSAKS-SF--------------------HQLSWQDPPGVGQEG
APA-G------AHQPSM--EP-LEETVS-AIS------P-A----TL----TQ-------
--------------------------DPVPLASTLSAE-PE-DR-------SNLEN----
------------------------------------------------------------
---------------------------------------------------------IPF
----------GTVA-----KSSPPGN----SFLAST--ISAMANLG-LFTSCPISF----
--------LS-CWWGTTK---TL---FFPT-----SSQSKSWKEDL--SPHS-TKAPSL-
GSNIDKHVEIG--S-PSFINP-DVQKLL-EILI-T------KR-------VELRICK-E-
GK--KDRSFSEQMS-----------------PDYH-LNT-S--G-----NMWKSLGTEQD
ITTP-------QSFWNVKDK----------------------PE---QLPEP QQLLHPES
LR-DHIEQKCSQLFWGLPS-LHSESLVAAAL-IPESSSQS--QAPFILFNGISN------
----------VFPVSIQPGIPLSLSQD----PLLP---------CAGAQ-PQPFTQNLPM
--YQPP-SMVQIQGQ-PYL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------P-----SPLLFRPTYSS--
-PQVS-----TCGLYYLPF-QNNPLYLTPTET----------------------------
--------------------QSLEYPL------LQKQLK---TEMPLPSVNKRSQEVFSQ
LIPNCPQDTG-----EPQAQRLVPGP--HG-DLIKSDLQKQHLQ--KKPM-EDQLK---G
RQ-LRSI-HLSLQLSSSQCQF-------------------LVTYQA-Q--GKQG-----S
W-Q----------------LTAFRGKRSQDTQK---TRSKC-PRRSHRRSQMKFQL---E
--TDF--SEGLRPCLRGI---------LKDPSR----S---SFLK-KFLQT-NSEKESER
YLLRPSKSDLLRPSKSDSRNY----LLGGPEK-KHLEKVLKAHLDK-KLRQIDQGLIP-V
TVRRSWLAAT---HAS--S---KTHLHKEIR-TLASLKHWK------PRINISHEISFLS
PSIQQMLEAHIIRFRIRHRWDTS-KQGSEPINLK---------PSEAQPSPLPTSTFSLS
AIW---QPGPQSKTNV--------------------------------------------
----------------------------SKFLGKP-QPHQGKQMITKASV--P-SLGSPL
-PAPIPARWDIQR-ALG-----KTSHGDSRGPSE-APLTGQKGRPPC--QMPAPNLKGRT
RQSG---TVLRARKSS--LNP--SLKREESWGWLSK--------YPCHNAL-ILD-----
-----MGLKSQSSR----S-----KQKAK--E--DPAWEIFLGPTVPVNSQI-SNMDLR-
RSDEPVTK-KTL-PPPTNAVGRYSKEPRFKTQVAGKFEFGSNLESENQLQGHATGDLLQQ
SHTDVLLQDYTTGMLLQDFATNLL----LQDPHTDVLLAADILASHRS--SSQMEHASGD
TPAS-QVPYDL---KESAQST--QEQ-Q-K--FQKPKDPFKSQ-REMLAPTEEWRDFQSF
QPGEHEEVRSIQRPQTPRKPKVRDPRKGPSASADDGETCEKLEPEEDRETISQGEMFAPT
EKRRGFKRPQQEEDEDMKSKREMLTIIDEWRKARRLQSRGKQKPKVRDPCKGPFASIQEE
RICENLELEEDEEINSQIEMCPPAGEWWSFNKPLPRGHQETESQSKIFTSTEACRAFKGF
QPGEPEEMKRQRERLTPTEEWKSIRRLQSGEQDLGSRQRQEKKQEPRKPKVRDPCKGLFA
SI---DEGEICEKPESEEDEEMNSQSAMCPPAGEWRGFKKPPPKGHEETKSRSEMLTSPE
DYRAFKRPQPRKSEEAKSQREMITPAEEWKSVRRLQPGEHEIASRQRQQKPRKPKVRDPC
KGPFASVNEGEVCEKPESEEDEEMNSQSAMCPPAGEWRGFKKPPPKGHEETKSRSEMLTS
PEDYRAFKRPQPRKSEEAKSQREMITPAEEWKSVRRLQPGEHEIASRQWQQKPRKPKVRD
PCKGPFASVNEGEVCEKPESEEDEEMNSQSAMCPPAGEWRGFKKPPPKGHEETESRSEML
TSPEDYRAFKRPQPRKSEEAKSQREMITPAEEWKSVRRLQPGEHEIASRQWQQKPRKPKV
RDPCKGPFASVDEGQVCERPKPEEDKEMHSQSR--MLAPPDER-------KGNWRPKLGQ
YEERL-SGLRASHTSVMSQSPQ-ERETESLGCKYLHFSP-EEEQLLAES--YLKKRMRHF
LQCLS-PNKKDK-QIEETFQKGRSAS--AAA---------Q-CQEQIKDK-FI-VD----
GKIIDPEVIGTVVGQILVEKLGLQQGTN--------------ASEVNHHRE---QLQALV
GG--HS-HH--HRTLYSSEQRKMLKNSVHSHQANPKD-HRHLSKSRHTRDRGDRW-----
------------------------AFPPREPES-SVRP-----CQHGPRVE--RDSE--D
LH--HW--P--ICWPQRCVSSG------------Q-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KT-------MTCQTVE-KT
KK--EEDIFSDPKR-----------------SECQ-LKA-P--W-----NLLGSTVIDED
IPVP-------QVSLNVKGK----------------------LG---KLGISEQQMRMTI
QG-RGLGQKHSQLFWGLPS-LHSESIVATLLVLPLNSYSL--EPQLMLFNGVCR------
----------AVTAPVLGYGCPAPPQP----HT-------------------PQPQPLSN
A--EPQ-PQTLP------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------FTQ----AHVQ-----SALAPLQ-SPS--
-LPCG--------SPPQMP-QDSTVSGVVHGN----------------------------
--------------------KDLQCHS------LENHQH---SLWGLVPKSQQYGTPFGL
LVPSLPLVSQ-----PSQNYASVP-R--TGHFHSGSELQGNLESYGPNNPIPPW-----C
YP---------------QFKT-------------------TETSPH-S--CKCV-----K
P-Q----------------RTVHWDQSCSNLRT---GEL-----SFYETVSMKPQL---R
--QDV--AKNLGQILGRC--------PLGNPQM----IS-GCYIL-NNLRV-IPET--QM
EWA--------CHSGVGLEHEGDGISRKSLDQ-RQTRSILRLHISR-KLWQITMGRIP-I
KVCCSWLAED---STL--WNLPP---------------GSF------YCNTAVLEIPFLD
PKTQKMLEAHLIRYRVSQKWGLP-IKVIESIKFY--------MLREAKTWPLPQSDLSLS
SNS---TSGIDVKSSF--------------------------------------------
----------------------------PYPLRENTNLYHNDRLETANST--S-IIDHLP
-LTISRIDGEGEW-PLG-----KSHSSNDYEVTE-KIQKTEGDTP---------SINDNV
SQND---AELPSRPGQ--E-Q--PVKEQVAGSKSQSEMASCSSHLEVIEGKQTVG-----
-----KHPPHMPIT----PGMLHEILGARNVSV-LSGSDPSSQAGSSTRKNE-D----S-
DEPDSVVT-TAH-NTSRVLLPED------PAQLFQELKLKLEKQSQGHTEGYET------
----------------------------------DGSFTSNSLTGYSM-S-SSNSVSSSE
ASIF-RSFHPQ---LCNTGIS--LDP-WREPSV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KHNT------------------MNLPVPRKEN
GKSET-RKTQTSKAGKKSQPITGKS-------------D-NQKSQPLES--YFRKKIGQL
FQWLY-SSKDNT-R-----------------------------HRTEKDRALF-MS----
CGPPEAHELMASLGKLLEDKLLYGQRSG--------------FLEWSQKKCLQAQ-SDPT
NG--QP-SK--HEA-ACAHHGEGKYICYCPQIATAPG-ASCML-SPRQTHPHVS-FEQQ-
PQFYSYLPS-LET-----------RDP---------------------------------
------------------------------------------------------------
-

-----------------------------------------MENFFSL------RSTGTT
---WLSSS---PTSWVIDTIIAFLCGLGL-------FLLLLPCFQ-SNQPLPPA------
------------------RKYINTRKHQVELRKRNR------SKKKSG------------
----------------------------------------------AL----KAC--RNC
LKE-------LE-GARSLIS-LLQ------------------------------------
---------GCLER---LPDKG-GF--------------------HQLLCQDPPGEVYKA
APT-G------AHLPCG--ET-VDDAAP-AMS------L-LAT PVP--------------
--------------------------L---TQCPLFLG-PTTSSVSVHS-HSSLSAS--W
PLEPF---------LPLDSL-----LPQPLALSPPPPCPFN---SEAC---PPPLTASSA
PQPP-----------------------------------------------DSILTLSQC
DS-ME--LPLDTIT-----QR-SSHTPW----SASP--DPVTLGLG-H-SSCPISA----
--------LS-WWQTAA---KAL---CLST-----STDYESQQEHL--FHHS-LEASFW-
GNPTDRQVGDA--N-PSLFSS-DDQKFL-EIEV-T------KG-------VKINIWK-E-
KE--KDGSYPQQMS-----------------PDYH-LNS-L--G-----SMLKSLGAEPS
TTSP-------QHFWNTKSK----------------------PQ---QLPDP QQLSYPKV
LG-HPLQHKYNQLFWGLPS-LHSESLVATAW-ISESSSAL---QSPFLFNGISN------
----------TCPVQMQAK--SLLSQS----KPLS---------QLEFQ-SQPLS-TTP-
-QFQPP-PLAQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ILTQEHLQ-----SSLPILSPSSS--
-PQIM-----ACKISSPTA-QDKSQFLIPTEI----------------------------
--------------------QHPEWPL------LQEQLE---SGWALSSVIKGSQEVFSV
FTSNLPEDSL-----V------VSIL--PENFPISPELRKQLEQHLQKWLIQHH-----W
EL-PRKIQ-ESLELRQLQGEL-------------------PGTCQA-K--GKHR-----P
S-Q----------------PSAFIGKSSKDTQK---VGF-----------QMSQGM---G
--K------GLGYILGKV--------PK-EFSR----NA-ESSLM-RFQGV-GSEES-ES
---------DVGLSKSDSESD----LLRSLD--KNLENILKGHLGR-KLGHVSEGLIP-E
SAHQSWLAVN---RAS--PMS---NTKMETR-NPGILKGWR------PYVNTTHRVSFLD
PDIREGLEAHIKRFWVRHRWGLL-LKILKPVNLL--------KLKKVQPLPVLQFSFTPS
ATC---VSGSPSIVKF--------------------------------------------
----------------------------AEFLGKPPKACLGKNAITEESA--A-TLKRPF
-LASSPMYGEIRT-GLG-----GIPSGDNQGPSK-ASLIGQEDRQPS--QSLTLKLRGRT
WQSG---SAECTEKSS--LEL--SPSSAMARNEPREESGDWTSQVPCHRVA-MLD-----
-----MNLGSQYYR----DEKAREIVEAKESP----------------------------
------------------GLQPQSGESSLNAEV-SEFKSRVKIKSENQPQDCPT------
----------------------------------HMLFDADNLASQVPHYH-LQRVPTED
-----KMLYGF---MVDQRNC--LKQ-Q-EPMISKLRDSW--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSHRK--MTDPTYKR-------EDCRRLNSGK
NEEQF-EALGTSQAECLSHSAPIRRIVDSVRSRCIQLLP-EKKQGPSES--LFRKRVRRF
FQWIF-PNKKVK-GQ-NVLQKCRPIT--ASA---------QS-QGPVKSRSIM--A----
SETPEAQALMTAVGQILEEKMAIHHGLH--------------ATKLNEHKQ---ELQAPV
CG--CF-CY--HRLPCYPEQGRIMNFTAHGHQASSKG-QRSSIRERQVKHRQTLKS--VR
FKDEQLGS--NFS-----------SLPSKKTLS-PVSP-----CQYGPRMP--SVPG---
-HHHHC--PRHCLIQGQ-ILSSQL------------------------------------
-

-----------------------------------------MENILSFL-----NRFFEP
---WLDFG---TFFLDIDPNYIFLSGVGF-------ILLYLWYLI-LKPFLPPY------
------------------WKSQDIKKWKSTA--KKGRR----------------------
---------------------------------------------RSF----KGY--RTT
---QR--Q--AQ-EWRKL------------------------------------------
----LSVVQSPLGE---LYDPS-HF--------------------RHLLCPDLSCDVCNG
ATT-K------ISRL-LSQAT-LEDGA--ASVSS---MD Y--TTVSV----TE---TSLT
LSLPLPENPLRNPTPDLPHEPSL------QSSSIISLH-KSAHLEDTLS-ASLLDDS--M
LSESVPP---VNAKFSLDPD-----SLHPRATSPLPQQHAT---QETEL-LLQPATILSP
MDSP----------RELFT-IPANKSI-FSSRHAMSE-----------------------
------------------------------------------------------------
---------F-IHQQTDT---DN---SFQL-----EPAHLVNQELL--DLHS-SESSLW-
GNITTCLTLPG--N-LPFPRP-DAMVLL-ERQD-G------KM-------AGSF------
-------------------------------------KT-W--G-----KTSE--SDQHS
LAVS-------HPLGRCKGK----------------------SK---RLHMN QQSPHLRT
SE-DQLGLKHIQLFWGLPS-LHSESMNSIAT-VWTDSSL-----ISGCFN----------
----------------RFSDSPVLINY----TPLS---------LPESQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLPQTLSLSQ----SQTVPPAKPPAQLQ-----YPIPVLSPSPL--
-TQLR-----ICGVYFHRP-QHKVQPLEPSAV----------------------------
--------------------HCLNYNI------LKKKLE---RVWGLPTVVKKSQEEFCP
PPPKPSLVKQ-----SSKTHVSRFIC--LGNFLLTSELQKKLEHHLRKRLILQR-----W
GL-PQRI-YKSLPWMNPLAEL-------------------PEASSS-T--SNYG----LS
W------------------ISFFKQQGSKDLHN---IVLNK-PGSFPTRQS--------A
-EKLL--KAR-EHSTEAV--------KKYQLWS----NT-KGTLD-NGLQS-NCETVLKH
H--------TGSLPGKPLG-----TLQVSQCW-KKLETALQKYLIR-HLGETNECQIS-G
TVSRSGYHPL----------LFTSH------------VDKE------EHEDQ-----RQS
PSDK--EDGHVKS-----------------------------------------------
---------------------------------------------KSVLQQT--------
------------------------------------------------------------
-----------------------------------------------------SIVLNNT
SLEE---S-E-SNKHSQDVP----RISNEAGPVSLGKRLYPSKTVRGHQGTKVNDK---S
TFVSNKV-----------S----NTVKGGQLSGLQSQ-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KK-------MSLQTLE-EA
KK--RDDTSPDPKR-----------------SEGK-LTA-P--W-----NSPGSTVTNLD
TQVS-------KINLKLKGK----------------------QK---YLGASDQVLCVKI
PE-GDLGQKHSQLFWGLPS-LHSESIVATVL-VPVSSYSP--EPCLVLFNGVCK------
----------AATAPVLSHGLPALPQP----HTW---------PLTLVH-PQPFPKVP--
P--QPQ-TLAER------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MPQ----AHMQ-----SSSSSMT-LLS--
-PPCG--------CALQIP-HTRTASDVFNGK----------------------------
--------------------EHLQYHL------LQNPQD---SLWSLVPECQRYETALEL
PVHSCPMGSQ-----SSQTYVSIP-G--SGPFHFSSEHQNNLDPYGANNLTSPW-----C
FEL-CDR-PGVPEVMNTKLKP-------------------TGVSSH-C--YKYT-----T
S-Q----------------CSMHWGNICADSGN---GELSH-LESYCVKVPMKPQL---R
--KDA--AKNLGQILGKC--------PLDNPQM----SS-GCCIL-NGLKA-IPKT--EG
ESA--------CHSRTGLDNGQLTISRKNLDQ-RHTRSVLRLHMSR-KYWQITMGRIP-I
MVCCSWLTED---ASL--WRSPL---------------GKI------HCDTAIPEIPFLD
HKTQKMLEAHLIRFRVSQQWGLP-IKVFESIKFY--------ILREGKTWPLPQSDLPLS
LNS---IPGLDLKSNF--------------------------------------------
----------------------------PSPLRGGSDLLHGDKRETTDSA--PST--DHS
-LILLHVDSEGER-SLR-----QSVSSPTSDVSE-MVQTVEGDRP---------SN-PDL
SQNE---AELQSRPSQ--EQQ--PIKEDVTPSDTENERASSSSHLVTSESRQSVE-----
-----RNPNY-MVT----PNMLREMILKARELCVQSGSDSSIKSQNFTQKDK-D----E-
SKSSPPVA-TGQ-SPSRTSVPEEPTAPDFKKQLFKELSSKLENQPQSQSETWED------
----------------------------------ESSFVSDSFSGYSP-PSSSNSASSTD
VSIF-WDTRGH---VYSTGIS--VDP-WQEPRV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ERILK--NFIPTQKR-------WALPVSRKEN
GRSNP-QELETPKAGKKSQPSKEKS-------------G-K-REHPPDS--SFRKKIGQF
FQWLY-SSKDSP-R-----------------------------HRSEKDRALF-MS----
CGPPEAHELMASLGKLLEDKLLYGQNSE--------------FLEWSQTTLP-AQ--PEL
RG--QP-SD--LGA-ANAHHEEEASNCSCPQTAITPG-PSHML-SLGQRHHHVS-FEYP-
PSAPESLSS-VQA-----------PLA---------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----RSYTET
---GLSPD---SHYLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKHQGRARRR---RKGG-------------------
----------------------------------------------TFKGN-VNR--KCF
QRE-------VE-EERKLLS-ILK------------------------------------
SFG-PPVSCSPLGQ---RHDTT-RF--------------------RRLLCPDPVCQVCNR
ATA-D------IQRL-LSRES-LKDAAP-----S---VSSLDS AGSA----TE---SSFT
LSSAPSATPTEDLILSPWPKLSL------PQ-LILSPD-LIASLADLFS-PSSLRDH--L
PPQPVSP---LDSKFPVDHS-----SPLQLPFP-LLPPRHI---QRVEP-SLQPEASFCL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDLLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--Q-----KMLSSMADKHD
LAES-------FPFGANKGK----------------------LE---GQHIH QQPPYSTC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----QESQVFPPP----QPLS---------LPSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPALLPSPL--
-FRIR-----ICGVCFHRP-QNEAQFLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALARK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSST-PRTFHERSSNMLSL----
--ENV--GNYQGHRQENG--------PKNHLLQ----DP-ETSSD-EDLRS-NSERDLDT
Y--------MMHLSGNHS--------GESLGQ-KQLENALTAHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEESHSQIKHQ-NLAALVSED------HGVDTSQEISFLS
PNKQKMLEAHIKSFRMRMLWGLP-RKILESIEIF--------KSKEDLSTSFSHFDIPSS
ASF---ISWGDSKVGVSKFRRRS--SFQGEKLGTT---------SSVPVLDGPHPVTSPI
AKEGQDTLRRQYSDTDHDFIESDSKDGASTLLRRGTADFQGEILESTNSL--P-ILGHSP
-LVTSPVDQEKQG-TLG-----REFADTDNDLTE-SVPTTEDGGQTF--LPPAHSIIDEV
SQKQ---TVP-ASRSSTEL-P---IMQAGVGRESRDKRESASNNVNRLQGSRKT------
FPV---------------TN----------GCALQSQTRNNLTSSKSGSCSV-TNVKTS-
TS---HET--E-IFPPRVSVPQDPKSSYLKNQMLSQLK--LVQRKDSQPQSHFT------
----------------------------------DMSLALENLSSKDL-LTHPQGISSGD
MGTS-QVLHVH---LEDRGIR--VAQ-QQEPRVPTHV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAIKR-------VSPMRPKGGE
LGGGD-AGLETSQLRRKSHAIHNKTSGEVLGSKSSPTL---KTQPPPEN--LFRKWMKTF
LQQFNKPTITYE-DQEISQAKGSSLS--SSV---------QN-RGRVTSRAAF-------
TGTTEAQKIRKDTRDSLGEKLGHKRGIDV-TCPQEPVSFPVEL-GKAQHYPEVQVRAELI
QGYPHN-----YMAPSCK----LTCTKSCSQQAVFVG-QNCATRIRQNTDKDRQPEKVEA
FKGKILCQR-HPQ-----------SV-----------------SLVCPAVL-ISAKS--T
VFSDVPLLTRQKMLPKH--FQG------GKFPPTK-------------------------
-

-------------------------------------MEFRKWNVLSFL-----NSPTDP
---CLSFG---STSLDINSDLILLCGLGL-------FLLFLWYLV-GFPCLPTF------
------------------CKIKGIQKRQGRTRRR---TKGG-------------------
----------------------------------------------TLK----GC--RFH
QIE-------TE-EKTKLIS-ILK------------------------------------
---------SPLGR---HDDTI-RF--------------------RQLLCPDPFCEVCNN
ATA-E------VNWL-LFPET-LEDSAS-----S---MSPLASTA PV----AD---SSLT
LSPDFSAVSPRDLLPASLPEPSP------LPPSILSPS-SMTPLADFLS-PSPLGHT--L
ALEPFTS---LDSEFSVDYS-----SPQPLAFP-PLLPHDM---QTACP-VLPPEATLSL
NTIFSLDPTLSHDINHLSDLSQAMKPADSF----APPSL-SVLPQ-PD----CTLTVTQA
KSV-------AILLTPVP-ENLPTESP---GVLSPY--VPTLTGID-HS-SLSISD----
--------FS-WWQAHAK---DLI---PS-----TLAQCDFNQEFL--ALHS-SEASFG-
GDPAANLIEPG--N-LSCLSP-DVLALL-ERQV-Q------KR-------SDFLMWK-EK
EKKKKKDSFPEQLR-----------------PDSQ-LNP-S--G-----IMLESVADK--
-------------------------------------------------PVH QQPPYPKT
VE-DQLQQKPTQLFWGLPS-LHSESLPSAVH-VSSDSSS-----NFI-FNRNSN------
----------ASTG----QESPGLPHP----QPLS---------LPEIQ-PE--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQSQ----PLPLTQVQSQADPK-----SPLLVTPPGPL--
-PQVR-----ICGVYFHRP-QNESESLSSSEI----------------------------
--------------------QQLEWNV------LQKQQE---SLWGLPSVIQRSQEAFCP
LAPNTSHHQH------PQAHVSVSIL--PGEFALSDELRKKLEHHLRKRLIQHR-----W
GL-PRRI-KESVSLMLPPDGF-------------------LEASKS-E--SSDG----VS
L------------------ISVFKGQSSKHV-S---VELIQ-PGSFRERSSEML-----Q
LEKDV--GKDQEHSQENG--------QEDHLLK----DP-NSSSD-KDLGY-DSEKNINS
Q--------IVSLSEKNLR-----GSAESL----QLENVLKVHLSK-KFEEINEGRLP-G
TVHSSWHAIK---QTL--MLSAKSHTEMKER-SLPSSVGEC------YSLNTFQDLTFVD
PSAQQMLEAHIKRFRMRMLWGLP-SKVLESIQIF--------KLKDASSQSLSHASFASS
TNA---ISEPDSKFGNSKSFR-SSKSFHGNKVGTT---------NSAPVLGHCPP-----
------------------------------------------------------------
--ATSLVGKEGQR-VLR-----QSHSAVNHELAE-DVQKIKDPRQIR--LPVSLCITGRG
SHRQ---VPL-ADGYPRKP-L---AKQAGARFEPKYKSMSSSDKGKMQQGKKV-K--SEP
VSM---------------PKVSREIFKAEELECLQLKTNDMLTTNKSGSSQI-TNVNEN-
KAETTVTT--E-SPPPKLPVPQDPKRVSLKEQLLDELKFRLEKRKHSEAEGQPI------
----------------------------------DMSLASDNLTYKAS-PIPGQGISGGD
TGES-QVLHVH---VEDRGIR--MEQ-QEEPWVPKHG--FQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------RCQDK--NFPPAVKR-------VSSPGCRAEE
LGGGD-AGLGTSQLRRKSFPPQETVREEMLVSKSSQTLS-KKGQSIPEG--RIRKRMKHF
LQWLY-PGGKRK-RREDPQEKGSPI---SSA---------QS-RGLVESRAAG-------
NGSTEAQKIVTDIRKFLEEKLGYRHELDA-TSSQEDPP-LVHF-GQSQKKAGVQVHTEPV
RGHPFN-----SKAP-SK----VTNTKSCHQEAILAG-QSYPPSTRQIRNKKRQPQKAVA
FKDQQLYQK-HPP-----------PVPHREPVPHPSPTHRCQAGQACPAVP-TTAEG--N
VSRDLSLLFRQKTLLQI--SKE------ENFPSKNNSFLVENVDPPQ-------------
-

-----------------------------------------MENILSFL-----NR---S
---WLGFG---SAFLDIGSNYIFLSGVWS-------ILLYLWYLI-LKQFFPPP------
------------------WKSQDIKKYQGSA--NKERR----------------------
---------------------------------------------KSL----KGC--RIT
---QR--K--SQ-EQREL------------------------------------------
----LSVVQSPLGE---EYDSS-NF--------------------RQLLCPDPYCGVCNG
ATA-K------ISHL-LSQAT-HQDGA--VTMSS---LDS---T VSV----TE---TALT
LSLPLPENTIDYPISDTACEPSL------QSSSIISSH-QSEYLEDTLS-LSPLGGS--L
LSESTPP---VNAKSPLDH------SLHSLASLPLPQQYVT---PETEL-LLQPTTVLSL
VDSP----------MELFANVPINNGI-CSSSHAMSE-----------------------
------------------------------------------------------------
---------F-IQQQTDT---GN---SSQL-----ESAHPVNQELL--DPYS-SESYLW-
GNTSTYLTLPG--N-LHFSSL-GAVALL-ETQD-G------RR-------TDSL------
-------------------------------------KT-W--E-----KTSE--FDHQN
LAVS-------HSLESSK-------------------------E---RLHTP QHLSYSKT
SE-DQLEDKNTQSFWGLPS-LHSESMNSIAT-VLTDSSL-----ISGCFN----------
----------------RFSDSPMLTHR----TTLP---------LSESQ-LH--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------NLSQSLSQSQ----SQPVSQANLQAQLQ-----LPNPVLSP-H---
-SQLR-----ICGVYFHSP-QNEAQPLEPTAI----------------------------
--------------------HCLEYNI------LKKEQE---RVWGLPTVVINSQQEFCP
PPPNPSLVSQ-----LSKTHVPKSIS--IEKCFITSELQKKFEHHLRKRLILQR-----W
GL-PKRI-RESLLWINPQAEL-------------------PESPSA-K--SNYG----LS
W------------------IPFFKQQSKKDLHK---TILSQ-PGSFPAKQL--------E
-EKLL--KLCSKQGLEMV--------QKQQTWS----NT-KGTLD-NGLQS-DCETNLQC
H--------SDSLSCKPLG-----TSEVSQCQ-KKLETSLKEHLTT-RLNETIERQIT-S
TMSGSRYGPF----------PFTSC------------VNKE------EHKAQ-------M
PSDI--KDRHVKSIS---------------------------------------------
---------------------------------TA----K-----KSVKQQT--------
------------------------------------------------------------
-----------------------------------------------------SFDLDNT
SLEE---S-K-GNRHSSDVP----KMLAEV----LGKRLTSGKTVQRPQATKIIDK---K
IFVSNKV-----------G-------KGGQLSGLQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----SSYIET
---GLSPD---SHYLDIDPTFICLSGLGL-------FILYLFYMV-LTLYLSPT------
------------------EKNNDIQKHQGRPRRR---RKSV-------------------
----------------------------------------------TF----KDR--KSF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCGLLGQ---HHDTT-RF--------------------RRLLCPDPLCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----C---VSPLPSG ASV----TE---SSFT
LSSTPSAIPTEDLILSPRPKLSP------PQ-LILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-SLHPVASLSL
NTIFSLDSTQCQD------ISQAMNPTDSCAHHNKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GETSTY--APTIKGID-HS-CPASSE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------QNYQ-LNS-S--R-----KMLSSIADKHD
MVEF-------FSFGANKGK----------------------LE---GQHIL QEPPYSKC
FE-DHFEQKYVQLFWGLPS-LHSESLHPTVL-GQRGRNS-----MFVFFNGITN------
----------ISRF----HKFPVLPSP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPQGQ----SPHLTQVQSQAQHQ-----SPLPVLLPSPL--
-FLIR-----ICGVCFHRP-QNEAQSLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSII-PRTLHERSSNMLSL----
--ENV--GNYQGCSQETG--------PKNHLLQ----DP-ETSSD-EDLRS-NSERDLDT
H--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSDD------HSVDTSQEISFLG
SNKQKMLKPILNLST---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPSLL-----ESIYTT
---WLSLS---STMWAMDVILAFVCGLGL-------YLLLLPFLD-SRLSSPLP------
------------------NIKFT-RRPQLRMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------W----------------------------------------
--------QS-WYRKKF---RT----------------------------------HYR-
KDPKAW------------------------------------G-------EGLRKLK-E-
KG--KDVLFLEEIS-----------------PGYH-LNS-L--G-----NMSKSPSTKQD
KTIL-------PPFWNLEEK----------------------SE---QEMATQKLSYPKI
LG-DHFQQKYKQLFWGLPS-LHSESLVAAAW-IPQT-STL--PSPFFLFNVISS------
----------VYPIEMQDKMSPVLSHT----HPLS---------YLDLR-PPPLILSPP-
-QFQPP-ALNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VHLQSSLP-----ALLPSSL-PYK--
----R-----DYGTSCSQS-QSKSQY-LPTEI----------------------------
--------------------QYRERPS------LTKQLE---SRLAFPLMDQRPQEAYDV
LAPNLSQD-L-----A------VSIL--PDNFPISFELREKLEQHIQKWLIQHR-----W
DL-PRKIQ-ESLEVMQFQNAV-------------------TEACQT-R--DKPG-----P
SPR----------------SFVSMGEHSKGGPK---VRF---------------QL---E
--KES--GKNLGPILGKV--------SK-DPIR----HL-EKT P----------------
----------------------------------NLENTLKSHLGT-KSGQINQGLIP-L
SVRRSWLAMN---NGF--S-----------T-NLTSSKNPE------KSVSSSQKLAFLN
PDTRQALEAHVVRFWVKHRWGLP-LKILKPINLF--------KLKNVRSLPIAVRAPPSS
TTS---VSGTSSSVEM--------------------------------------------
----------------------------VRLLGKPSQTCFREVV-IKDSS----SLGSLL
-LISSPSCKDIER-ALG-----VLPSDVDHEPSK-TLPTKPESRHHP--ETLTYNFMDTP
SQSG---I----------------------------------------------------
------V-----------------------------------------------------
LEKERDTQ-EVL-LLSRRTSVQNPGAHSHQAKVVSEFPHNVKTDSADQPQVYTTAV----
--------------LLPE-------------HSRSRLLPADTLASQVLG----------D
---------IV---VVGGGNS--LVQ-Q-KPSTPKHQVSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGKIK--VLPPTYQG-------EDTKNQSTGK
HEEGP-KF------------SRVKEKEDKFRSKHYQPPP-KPKQVPPES--PFQKLVSRF
LRWIH-PKETIK-GQQSPPKKGKPTT--TTA---------QSQQRQVKKKPHV--D----
SNVAEAQELMTAVGEMLEKKMMLQRELY--------------ASKFNHQRE---TPPSRA
PQ--AS-YG--HKPASNSEQRRAPSHP-----ASSSC-KKCSIQDR---NQPPQKN--VR
FSNELQT------------PQNPSVLSPNTASN-LVSS-----SQSGTVMP--GVSS--H
Q--LHC--PRHCVLRRS-ICS-QLQSSSLVFSSRRT------------------------
-

-----------------------------------------MENIFSSL-----NGLTET
---WLTFG---SASYHKYLSYILLSGLGL-------LLLYISSLI-VRLLARSL------
------------------QRKKYAPKLQNNI--RHRRG----------------------
---------------------------------------------KAF----KRK--KAG
---QR--D--PE-TAKKL------------------------------------------
----QITLQ-S--K---PHNPT-GF--------------------RQLLWSEPLCSIYNK
TSP-L------VSYL-LSQAP-LEDGGDAALVSS---L---PSRA PV----TE---APIA
LPSGFPANQPGLPALEAPLH---------TSLSTLSQD-QITPPDGVS-PSTPLRAS--L
SPQAIAP---LKPAVLLTHT-----PCKMLTSSP----LAT---QEAQL-ALRAE-----
--SP----------REQSSNASTAKST-IYES----A-----------------------
------------------------------------------------------------
---------S-SQLWFSA---ED---QPRT-----NLPHV--------KPYA-SRGSYR-
RLTKVHAAEPE--D-HLSPGP-DVLALF-KRQE-K------RD-------ADVAAYK-LK
KE--KTVSFLI-----------------------P-EST-S--G-----EISASSADVEN
ADLY-------HLLGKKKGE----------------------PG---GPHPQ QEPSHLKN
SE-DQSEIKDNQLFWGLPS-LHSESLKHEAA-NSVNSYP-----ERDDFH----------
----------RIAEASTGRESSNLTYP----IPLL---------LPESD-QQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GQT--VPQSQ----IKPDSPTDSKAQTQ-----SRLPFLPSSPQ--
-SQLR-----ICGVRFHSL-KDEGQPLAPYEL----------------------------
--------------------QQLEYNL------LQKTLQ---GFLGLPTLTQRFQEGFGP
SPPKISSTRH-----SSKAHAPKKIL--PGDFPFNYKLERKLEHHLRKRLIQRR-----W
GL-PQRI-RESLSFMNPHSKI-------------------PEVPEA-R--NSHG----LS
W------------------ISHYKFNTNS-LSG---LGLSQ-TSSFHKKPLESHSL---K
-AKDV--KVQ-GQCPGIG--------QRDHIQG----DS-SGALM-SRVHS-NSETDPEL
Q--------LRDMSGKISK-----ASLVKQCQ-RECESFLQEQLGR-NTKEISRGEMS-S
AADRSGHSTN---MAQ--TPPGTSPRQV------APLLSEE------DARKEHEHSLTLS
DNQEKVLEEHITDFGRRMAFGLP-QRVEESLESY--------LTRAEPSQPFPQLHTRAH
SVCT-VDSDKPSRFL--------RRNTNGDRKGTV----D-----LVPVQHR--------
----------------------------------------------------------PL
PAA-WLAGHTQPASENK-----------KVCVDK-DLSMAPSGREPI--KHWTPSMAHKG
IRQH---SRS-DSRPDPEPP----MSPD----GPTEERLASSNNTQGSQGERKNWK---D
CSMAEGS-----------T----DLHKGEQLPGPDPQSTKNLKGTQDLCSPG-S------
-----HAT-ECQ-SLQGMSVPQDSETPHSKSQVSTEVVPNSEGETHIQVPDLPA------
----------------------------------TAFA-SEEMT------SKPRGPSSGD
MAVS-QVLHVH---FPSVGIN--MEP-RQGPWVPAY--VSG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSKNK--DC-PPAARG------VPPLVTEAGK
LGGGD-AGLGTSQTRGKRHCAQARAAEETQGHTSSPA-LTPK-SQPLEN--QFPNQVKGF
WQRLS-PGRKHK-GQEKILARGCSSL--MPV---------KG-ASLIKGRCEF-------
CGNTAAQKCVREPGMVLRKQLGFRHWTVI-PCPQAPVS-PLMGSVEAQQELQLQAQAEPA
QRLPHF-C---CRASCSQ----VQRAESCSPGQGQTA-LER-----CGTTGKAKMVEPSP
MHA-------S------------PPKSYL-------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTES
---GLSPG--LVHCLDIDPNFICLSGLGL-------FMLYLFYVL-LTLYLSPP------
------------------GKNDDIQMHQGRARRRK---KGG-------------------
-------------------------------------------------TF-KDQ--ITF
QKE-------AE-EERKLVS-FLK------------------------------------
SFR-PPASCSPLGQ---HHDTT-RF--------------------RRLLCPDPLCVVCNR
TTA-E------VQRL-LCWES-LKDAAP-----S---VSSLASAA SV----TE---SSFT
LASVPSTTPPEHLILSPCPDSSP------PPALILSPE-LITPLADLFS-PSPLRDP--L
PPKPVSP---LDSKFPIDHS-----PPQRLPFP-LLPPHHI---QRAEP-NLQPEASLSL
NTIFSFNYALSQGMNPLQNISQEMNPTDSCACRHEPPTS-SSLPP-QD----C--TVTQS
KAS-------LTIFMPFS-ETLSLFGS---GGSSTY--FPTIEDID-YS-WPASAE----
--------FS-WWQPHAK---DSF---SS-----NFVPSDFMQELL--SLHY-SEASLG-
RYTVVNLIVPV--R-LSFVSH-DIVALL-ERQV-K------KR-------GDFLMCK-EN
GK--KPGTSPKHLR-----------------PNYQ-LNS-S--G-----KMLASIADKHG
LAAS-------LPFRASNRK----------------------VE---RLHIH QQPPYSKC
SE-DHLEQKYVQFFWGLPS-LHSESLNSNVL-LQCGCSS-----MFVFFNEIAS------
----------MSTF----QEPPVLPHL----QPLS---------LPITQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLCQTLPQGQ----SL--------SQHP-----SPLTVQLPSPL--
-FQIG-----ICGVCFHKS-QNEAQSLTPSEI----------------------------
--------------------NHLEWNV------LQKLLE---SVWGLPSVVQKSQEDFCS
PAPSLGLV-K-----SFKACCPISII--PGDFPLSAEFRKKLEHHIQKRLIQHR-----W
GL-PRRI-HESLSLLRPQSPI-------------------VEISES-E--NSEG----PL
H------------------KSLVEGQSHNDLKN---FKSRK-PRSFHKRSSNMLSL----
--ENV--GKFQGYSQENG--------PKDHLLH----EP-ETSSE-KDLSS-NSESNLEG
H--------MMHLPGNDL--------GVSLGQ-KQLANALTVHLSK-KFEEISKGQVP-W
SVRSSWHSVK---QTI--SLPEKSHSQANHQ-NLAALVGED------YCIDTSQEMSFLG
SNKQKMLEAHIKSFHM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPSIL-----ESIYTT
---WLSLN---STMWAMDVILAFVCGLGL-------YILLLPFLE-SHLSSPLP------
------------------NMKFT-RRPQLQMT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------C----------------------------------------
--------QS-RCRKKF---RT----------------------------------FFW-
KDPK-----------------------------------------------GLKKLK-E-
KG--KDGLFLEEIS-----------------PGHH-LNS-L--G-----NMSRSLSTKQD
STTL-------PPFWNLEEK----------------------SE---QQMATQKLSYPKI
LG-DHFQQKYKQLFWGLPS-LHSESLVAAAW-ISQTSSTL--PSPFFLFNVISS------
----------VYPIQMQDKMSSVLSHT----HPLS---------YLDLQ-SPPLILSPP-
-QFQPP-VLNQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VHLQSPLP-----ALLPSPL-PYT--
----R-----DYGTSCSQS-QSKPQC-LPTEA----------------------------
--------------------QYRERPS------LAKQPE---SRLAFPLMDQRPQKVYDV
LAPDLSQD-L-----A------VSIL--PDNFPISSELREKLEQHIQKWLIQHR-----W
DL-PRKIQ-ESLDVMQFQNIV-------------------TATCQT-R--DKPG-----C
S-Q----------------PFVSVGEHSKDGQK---VRF---------------QL---E
--KES--GKNLGPILGKI--------SK-DPIR----YL-EKPP----------------
----------------------------------NLENTLKSHLGT-KSGQINQGLIP-L
SVRRSWLAMN---KA--------------------SSKSSE------KSVSSSQKLAFLD
PDTRQSLEAHVVRFWVKHRWSLP-LKILKPIHLF--------KLKSVESLPIAVCAPPLE
NTP---VSGTSSSIEV--------------------------------------------
----------------------------VGFLEKPSQTCFREVI-IKDSS----SLGNLL
-LVS-SSCKDIEK-ALG-----VLPCDVDHESSK-ALPTKPESRHHS--EILTHNLMDTL
SQSG---T----------------------------------------------------
------V-----------------------------------------------------
LEKEKEMK-EVL-LLSKRTS-----PHSHQAKVVSESPNNVKTESAGQSQVYTTSV----
--------------FLPE-------------HSRSMLLTKDTLASQVLG----------D
---------IV---VVGGDNS--LVQ-Q-KPSTPKHQLSQ--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KEQIK--VLAPTYQG-------EDTKNQSKGK
HEEKP-KF------------TRVKEKEEIFRSKHYQPPP-KPTLVPPES--PFQKLLSRF
FRWIQ-LKRTIK-EQKSPPKKGKPTT--TAQ----------SQPKQ-VKKKHV--D----
SNVAEAQELMAAVGEILEKKMMLQRTLR--------------DSKFNQQRE---TRPPHA
PQ--SS-YG--HQPASNTEQRRTPSHP-----ASSSC-KKCSIQDRH-RDQPSQKI--VR
FSNEPQT------------PQDPSLLSSNTPSN-LVCS-----SYYGRVVL--GVSG--H
Q--LHC--PRHCALRRS-VCS-QL------------------------------------
-

-----------------------------------------MEKILSAL-----NGLSET
---WLTLG---SASYHIDLNYTLLSGLGL-------LLLYISYLI-LKLLIHLL------
------------------WREKYTPKRQNSI--RRKQR----------------------
---------------------------------------------KAF----KRR--KVG
---PR--D--PE-EGRRL------------------------------------------
----QTVLQ-SPDK---PYDPT-GF--------------------RQALCPDPRCRVCNK
AST-Q------VRHL-LSQAP-LEDGA--ASVSS---L---PSTA PL----IE---ASIA
LPPHFPANRPGHPAPETPPH---------TSRSIHLQN-QITPLDGVSSPPISLSAS--L
SPQAAAS---LNPAVLPAHT-----PRRTLASFPHLHPNAT---QEAQL-ALQAEVPQPP
VESP----------RERSPSVSTAKST-VYEP----A-----------------------
------------------------------------------------------------
---------S-SLPQFTA---ED---QSLT-----NSTHVINHQPPPSDSYA-SQGSYQ-
GLTKAYAVEPG--D-HLSPSP-DVLALF-TKQA-E------GD-------ADGTVYK-LK
KE--KAVSYIM-----------------------P-SNT-S--G-----EISASTAGLEN
LEVS-------HLLGNENGK----------------------PE---DPHLL QQPSHLKN
SE-DQSEITDIQLFWGLPS-LHSESLKHEAA-NTGNSYP-----GRDYFD----------
----------KVAQASTGSHSSSLTYS----TPLP---------LPESD-QQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------RQI--VPQSQ----IMPDSLANSKAQPQ-----SLAQLLPPSPQ--
-SQLG-----ICGVRFHSL-KNEAQPLTPCEI----------------------------
--------------------QQLEYNL------LQKALQ---SFLGLPTLTETFQESFCP
PPPKISSTRN-----SSKVHAPKTIL--PGDFPLSHTLKRKLEHHLRKRLIQRH-----W
GL-PHRI-LESLSFLSPHSEI-------------------PEAPKP-R--DTHG----LS
W------------------VSLYKFNANTNLPS---SGVSQ-SGRSCKKPLESHPP---Q
-EKDI--NVQ-RHRPGIN--------HRDPIQC----KS-CGATK-STVHS-NSETDPEL
Q--------LGNRSGNISK-----ASWVKQCQ-KECEAYLQKHLGK-DTKEISGSERP-S
AVDSSRHSRN---MTQ--PPPETCPRQM------APLACEE------DALTRHPHSLAIG
PSKEKTLEEHITAFRRRMAFGLP-KRVEESLESD--------LTKAESSHPFPQLHVQAH
NVSG-ADSAKSSRPL--------RRNTTGDRMGTV----N-----SVPTQQRPLPAASLV
GHSQPASENXXXXXX-XXXXXXXEGRKEGRKEGRXXXXXTGDRMGTVNSV--P-TQQRPL
PAA-SLVGHSQPASENK-----------KVGVDR-DLSVTPRGREPT--QHWTPRRADKG
DVQQ---SGS-HNRPGPELP----MSPG----GPTHERLASSTNTQGSQEERRSRE---D
GSKAEGS-----------T----ELHKGEQLPSLHPQSTKSLKGTQDLCSPG-N------
-----PVT-ACQ-SPKGMSVLHNSESPDSKSQVSTEVQLNSAGRTHNQVPDLPA------
----------------------------------TPFA-PQEMT------SKPQGPSGGD
MAVS-QVLRVH---MPTVGIS--MEK-S--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MKTVLSIFNSSILTSAKES
---WLSIG---SVFVDIYPKCIILSVLGL-------LFLFLRYLI-LKPFLP-T------
------------------QTSQGVRKQQGRA--KRERR----------------------
---------------------------------------------ASF----NEF--RNF
---HG--E--AR-ERRKL------------------------------------------
----QAVVQSPCGQ---LYDPF-YF--------------------RQALCQDPRCDVCNG
ATV-K------VRRL-LSWAS-LEDCS--ASASS---MASMA STASV----TE---ASFT
LSSSLSPSPSGYQLSSFSVAPSP------PPPSILSTS-TLTPLEDILL-GTPQGDS--L
PPEPTLT----STSFPLDHL-----LPHPLPKSPSVAHPAA---QQTEGPLRPED-ILSL
AGSH----------GDQFLHATTTCDA-LP------G-----------------------
------------------------------------------------------------
---------S-YQQQPGA---QS---SSPS-----QLKCLVNQEIP--NHCS--SEDFWR
GQASPHFTVPQ-----------KVLKIL-ERQE-E------SQ-------ADVLTLK-DR
EG--EAEP----------------------------------------------TAE-QN
LGAS-------FPLEGSRVI----------------------LS---ELNPQ QGLAQVQS
SG-GLLEAMPMQHFWGLPY-LHSESMSCITT-LSSHCSS-----MCIWFN----------
----------------RTTDSPALAPP----SPLP---------LPERQ-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------TLTQSQ----SQSIQ-------LQ-----T-LPGPSPSSQ--
-SQVR-----VCGVYFRSS-Q-EAKALLQSEI----------------------------
--------------------HHLEYNM------MAKDPE---REWALPSVVQKPQEELSL
LPSKLSLAIK-----SSKLQTPRSVP--PRDFPLADGFQKMFEQHLRKRLILQR-----W
GL-PQGI-YKSQLWANPDPS-----------------------EAS-K--SSSG----LS
G---------------------FKHKDNKAWSN---TVSNQ-SGSPQEK---SVSV---E
-RKTV--KAH-EQTLEII--------QK-YICS----NS-KTALD-NSLPS-DHE-NLQG
H--------SGSLSDQSSE-----TSQVSQCR-KKFETPPKEHLKS-HIDGTNEDQIP-V
TLSRLKHRPL----------HFKPC------------VGKE------EKKAE-----RQS
PSDI--KDEDSKSVH---------------------------------------------
---------------------------------RI----T-----VPGVQQT--------
------------------------------------------------------------
-----------------------------------------------------SVVLDTT
ILKE---S-E-AKKPSPDAP----KMLAKAGPMPVGKSLSSSKIVQGPQGTKMDDK---H
VFVSNKV-----------S----NIVK-EQLGGLQPRPTKISKASQCKSAKD-GDGNTP-
SAQR-TQL-AGR-APEGISGPPHIQASDFSCQVTREEKSESENRQPIQASEPPK------
----------------------------------VVLPVSDKLTHTP-LPIHDQMPSSAP
TNAA-QVQ-------------------PQEPEMPAH--PLG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KGLNK--DS-PQSAKR------SWPA-WKIE-
---GV-AGPETLQPSGKSHRAQDSPTPGDHGKRPIPPSPPVKALSPPEH--HFRKHVKHF
FQWLS-PDRKCK-GQEALLKRGASPP--SPA---------HD-PE-LKGRATF-------
PGNTVAQKALRDFGKVPKEQPGHRHGAADTMRPRVPVSPPTKPV-KTKPKREYCVPTDPV
QGR-QL-H---PPAPVSK----VPSPRFHNQAAAFVD-QKR-----CVAERARQPQKCEA
LQP-------R------------PSASHRESELRQ-NLLWSRAGKVPQGTP-PFAVG--T
MLADMSRLCEQKILAQN--FRG------KAFVPQK-------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KK-------MSPQTLE-EV
KK--RDDISPDPKR-----------------SEGK-LTA-M--W-----NSPGSTVTNLD
TQVP-------KINLKLKGK----------------------RK---YFGAYDQVLCVKI
PE-GDLGQKHSQLFWGLPS-LHSESIMATLL-VPVSSYSP--EPCLVLFNGVCK------
----------TASAPVLSHGLPALPQP-----------------LTLVH-PQPLPKVA--
P--QPQ-TLTEG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MPQ----AHMQ-----SPLSSMA-LPS--
-LPCG--------SALQIP-QTRTVSDVLNGK----------------------------
--------------------GHLQYHL------VQNPQD---SLWGLVPECQQYETALGL
PVHSFPVDSQ-----SSQTYVSVP-G--SGLFHFSSEHQNNLDPYGPNNLTSPS-----C
FEL-CNR-PGVPEVMNTQFKP-------------------TGVSSY-C--YKYA-----T
S-Q----------------CCLHWGNICADPGN---GELSH-SESYCVKVPMKPQL---R
--KDA--AKNLGQILGKC--------PLDNTQM----IS-GCCIL-NGLKT-IPET--EG
ESV--------CHSRTSLENEQLTISKKNLDQ-RHMRSILRLHMSR-KCWQITMGRIP-I
VVCCSWLAED---ASL--WRSPL---------------GKI------HCDTAIPEIPFLD
HKTQKMLEAHLIRFRVSQQWGLP-IKVIESIKFY--------ILREAKTWPLPQSDLPLS
LNS---IPGLDLKSNF--------------------------------------------
----------------------------PSPLRGSSDLLHGDKIETTDSA--PTT--DYS
-LTHLHVDSEGER-SPR-----QSVSSPTSDVSE----TVEGDRP---------SN-PDL
SQNE---TELQSRPRQ--E-Q--PVKQDVTPSDSENESASSASYLVTAESRQSVE-----
-----KNPKY-TVT----PNMLREMILKARELFVRSGSDSIIKSESSTKKDE-D----E-
SLSSPLVA-TGQ-SPSKMPVPEEPTAPDFKKQLLKELRSKLEDQPQSQSEAWED------
----------------------------------ESSFVSDSF---SL-PSSSNSVSSAD
VSVF-WDTQGH---MYSTGIS--VDP-WQEPSV------F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRFFK--NFIPAQKR-------LALPVSRKEN
GRSNP-QELEKPKAGKKSQPSKEKS-------------S-K-REHPPDS--YFRKKIGQF
FQWLY-SSKDSP-R-----------------------------HRSEKDGALF-MS----
CGPPEAHELMASLGKLLEDKLLYGQNSE--------------FLEWSQTSML-AQ--PAL
KG--QP-SD--LGA-ADGHHGEEASNCSCPQTAITPG-PSHML-SLGQRHHPVP-FEYP-
PSAPESLSS-VQA-----------PLA---------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPD---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSAT------
------------------EKNNDIQKVR--------------------------------
----------------------------------------------------NYR--KCF
QRE-------VE-EERKLLP-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-HF--------------------RRLLCPDPDCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSTPSATPTEDLILSPRPKLSP------PPQLILSPD-LITSLADLFS-PSSLRDP--L
PPQPVSP---LDSKFPVDHS-----SPLRLPFP-LLPPPHI---QRAEP-SLQPEANFCL
NTTFSLDSTQCQD------ISQAMNPTDSCAHHYKPPIP-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GGTSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPCAK---DSF---SS-----NFVPSDFMEELL--TLHS-SEVSLG-
GHSVANVIQPV--N-ISFVSH-DILALL-ERQV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------PNYQ-LNS-S--R-----KMLSSIADKHD
LAES-------FPFRASKGK----------------------LE---GQHIH QEPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGCSS-----MFVFFNGITN------
----------TSLF----QESPVLPPP----QPLS---------LLSTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------SLPQTLPQGQ----SPHLTEVQSQAQHQ-----SPLPALLPSPP--
-FLIK-----ICGVCFHRP-QNEARSLTPSEI----------------------------
--------------------NHLECNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNLTLVRK-----SFKVHVPIAII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------LELSVS-E--SIQG----PL
H------------------SSSVEGQSLNVLKK---FGSST-PGTFHERSSNMLSL----
--ENV--GNYQGYRQENG--------PKNHLLH----DP-ETSSD-ENPRS-NSERDLDT
H--------MMH------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFHCDDPP-------
SPSP------------------GKRKCPVGRRRRPRGR------MKN-------------
---------------------------------------------HSL----RAG--REC
PRG-------LE-ETSDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--PPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-RWQETAR---TSC-----------AFNSSVQQDPL--SRHP-PE-----
----TCQMEAG--S-LFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNQMT-----------------PEKH-LNS-L--G-----NLAKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKCSDPRL
LQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPLS---------H-----RQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFL----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLRDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDL--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
RVRRSWLAVN---QAL-----PVSNTHVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQGLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPAWKQFQR-APR-----GIPSWNDHGPLK-PPPAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVSEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLVSQVP-QGHLQSMPTGN
MRAS-QELHDL---MAARRSK--LVQ-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKSRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSVS--HFGENIKQF
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
SSSAEAQGLMTAVGQMLDKKMSLCHAHH--------------ASKVNQHKQ---KFQAPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M-K------KT-------MTCQALE-KN
TK--DEGIFPEPKG-----------------SECQ-LPA-P--W-----DFLGSSATDQD
APAP-------QANWNLKGK----------------------LG---KLGISEKLLRMTI
LG-GDLGQKRSQLFWGLPS-LHSESIVATLLVLPLNSYPL--EPHLVLFNGVCR------
----------AVAAPGLGHGSAALPQP----HTL---------PLSFAG-PQPFPR---G
A--RPQ-PQTLP------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------FPR----AHVR-----CPPSPMR-SPP--
-LPRG--------RTFQRP-HTRTVSGVLGGN----------------------------
--------------------EHLQGYL------LQNHQD---SLWSLVPEWQQYGTPFGL
LVPSLPLVSQ-----PSRNYVSTP-R--TGHFHFGSELQDNLEPYGPNNPIPPW-----C
YHQASGR-TGVLEVMVPRFKP-------------------TETSPH-S--CKCT-----R
P-Q----------------RTVHWDQSCSDLRT---AEPRR-SGSFCERASVKPQL---N
--KDV--AQNLGQILGKC--------PFGSPQM----IS-GCYVL-KGLRV-VPET--EI
KWA--------CPSGVGLENEQDGISRKSLDQ-RQTRSILRLHVSR-KLWQITMGRIP-I
KVCCSWLAED---EML--KNSPT---------------GST------HCDTSVPAIPFLD
HKTQKMLEAHLIRYRVSQKWGPP-IKVIESIKFY--------MSREAKTWPLPQPDHPLS
-------SGIDLKRSF--------------------------------------------
----------------------------PRPLGENSKLSRKDNMETADVD--S-IIDHLP
-LTISHADGEGEG-PLG-----KSHPGNGYEVTE-TTQATEGDRL---------SSDDNT
SQYD---AELQIRPWQ--E-Q--PIKELVAESKSQNEVAS-PSRLAVTGGREIVG-----
-----KHPAPVLIA----PDT---LLGARDVSVVLSGLGPGCNWEGPVRQSE-V----G-
SEPASAAA-TPH-NPSRVSLPQEQ-----AKQLFNELKLKLEQQSQSQAEGYES------
----------------------------------DVSFASDSVAGFSL-S-SSNSASSTD
VSVF-RDFHPH---LCNTGTG--LDP-WPG--V------L--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------GHNA------------------GSLAPAEKRP
ASPDN-GKSETPKSEKRSQPVAGKS-------------D-K-KSHPPES--YFRRKIGQL
FQWLY-SRKDNT-R-----------------------------RRTEKDRALF-MS----
CGPPEAHELMATLGKLLEDKLLCRQRSG--------------FLEWSQKNCLQAQ-PEPT
NR--QP-SN--QGA-SYAQHGGGKPNCYRPQTAIAPG-PG--------QRHHVS-FGQQ-
PQFWSYFPS-CES-----------RDL---------------------------------
------------------------------------------------------------
-

-----------------------------------------MEKMLFPL-----KSPSAT
---WLSPS---STPWMMDFILTSVCGLVL-------LYLLLSYLH-SDPPSPPP------
------------------GRKRSSREPQRERRGRSRSR------KKIS------------
----------------------------------------------AL----KAC--RNL
LRE-------LE-ETRDLNN-LLE------------------------------------
---------SHLRK---LAGEG-GS--------------------HLPLGGDPPGDVCKP
APA-K------AHQLHG--KC-MPDLSP-TSL------S------PA----A--------
--------------------------PPA PLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPLSTQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----TRPVP-----KSSPLHS----QGPPSP--TRVISGLG-RS-SDPIWD----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDQP-LEASFW-
GDPTPRHVEVG--V-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-G-
KE--RERADH---------------------------------------PQMTSLGKEWD
ITTL-------DPFWNVSTE----------------------PQ---QLPCP QQVSDATA
VG-DHLQQKCSQLFWNLPS-FNSESLVATAW-VSSKPSSQ--NAHSVSLDEAST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQRFTPAWPQ
--SQPP-PLAGIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLPCSSP--
-PQIR-----DCGASYPTT-QEKTESVIPAGK----------------------------
--------------------ENLEWTL------KKR-PK---WKRVLPSLLQKSPTVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VATSPELPEHRWQ-GRSAI-HQEQS---C
GP-PSGF-RASGDLPPPEGEF-------------------PGRPQS-R--AADTQEALLP
S-Q----------------ASGFAGKGRKDVQK---AGFRS-SGR---------------
--------FSGKGCLRSK---------LGPDPSRDR-GS-GRTSV-KFLE--EDKEEAEG
DMW--------RPWKYQSVNS----APRDPDK-EHLENNLQIHLAR-KVGEIKEGWIP-V
PVRRSWLMVK---CAV--P---QSDAHRKPG-KLAS---WR---GGKAHANTSRELSFLQ
PCTQQMLEVHLLRFRVRHRWGPD-LQSLEPINVW---------SGEAQAPPFPQSTFPPW
ASW---ESRDESAANV--------------------------------------------
----------------------------PIFLGKRPQNGPGDNRTTSKSV--L-MVSGAL
-ASAAPEQEEAQR-PLR-----GSQSADTHGRSE-AFPSRHEDRGFS--QPPTCSLVGRT
WQSR---TVLASGKPKPRLEG--STGSEIPGNEARFESESMSPGDMCSSRA-LQE-----
-----LSIGSQWAR----AEDALEALKVGEEK--PPAWDVTVGASVRTSSGS-IQVDLR-
STGALGTT-DNP-SGSTICVAQDPEQLRLKAQVVNEIALLVQVDSEEQPPGRASGVLL--
----------------QDGAIDLC----LPGRHVDMLPATDRLPAQ-TPLSTPQSVSSKN
TTVS-QGPWAL---LWKGGDS--SGQ-R-EPGSPKAKAPQKS--QKTLGSADKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------RRRPRPGE
QGHGS-KGPRTSEASGRSHSAHTREIGDKQERKYNQPQP-EKRETPPES--HFRRKIGHH
PRGLH-PRKTGA-GWEDVLEKGKPGA--DAV---------Q-SWGSGPAR-LF-MD----
CMVDEAWTISRVVGQILVDKLGLPWGRG--------------PSDVSRHKG---DLHAQE
NV--PS-CG--HRGHCHQEHSREMRAPACSPKATPRG-HHCPVKNRNIRDRDSRW-----
------------------------APPPREPVS-PAGP-----HHHRPRVA--SASG--G
PI--CG--LHRGLAS---------------------------------------------
-

------------------------------------------------------------
-------------------------------------------MS-PSLSFF--------
---------------------SFCSQHQGRAKRRRKGR--I-------------------
--------------------------------------------LKG-------W--RAC
---QS--E--VE-DARKVLS-LL-------------------------------------
--------QSPLGQ---HDDTT-RF--------------------RQLLCPDTSCEVCNN
ASA-E------VSRL-LFPEA-LEDAT-----SS---VSPLASTA PV----TD---SSFI
Q-----------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
KSI-------SILSKPVL-EKSSSDSP---DGFSTC--VPTIRGTE-HS-GLSSSD----
--------FS-WWKAHVN---KM---FLPT-----LPHSDIQQEHV--SFHL-PETCLC-
RDSVTKDMEAS--S-HSFLGL-NIQALM-KRQI-K------KR-------MAFQNLE-KK
EK--EEGPFSKQ------------M-----WSEYQ-RTS-S--R-----NSLKSL-DIQD
NVDP-------QTDSNVESK----------------------SE---QLHIC QQLLYVKT
LG-GNLQQKYSQLFWGLPS-LHSESLVATLL-VSSSSSPL--ESHFVLFNGVCN------
----------GSSVKMHDQESPPHLHS----HPLP---------LPHVH-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTKPKSQ----PLPFTQVQPQVNLQ-----SRLPILPSSPP--
-SQIR-----DCGVSFHRL-QNESDFHIATEN----------------------------
--------------------QHLEWHV------LQKQQE---SLWGLVPMLHKSQEATCP
RALNLPLVNQ-----SSHACVPVSII--PDHFHITSEPQEKLELHVPRRLIPRW-----C
LQ-ACRN-LESLALMEPQYKL-------------------IEVSQQ-R--GRHV----HL
Q------------------LSELNGQHSKDLGM---TELGL-PGSFHERVPTKFQL---R
--DDM--RKNLGYILEKS--------PEDRPQG----AS-ECYLV-QGLRP-AL--GTQS
N--------CVCNSRNHSSYELLNVSRKDIDR-NQIKTILRLHVST-KSWQISAGRIP-V
GVCRSWLAED---NTL--PPSRSSQTNMEDANSENTKVARA------YCQTSTLELSFLN
PNTRKVLEAHILRFRVTQRWGLP-LKVLESIKFY--------MLREAKTWPLPQFDFPSS
TTH---VSGADSKTEIS-------------------------------------------
-----------------------------KPLEGSSTTSQGKKMRTTNSV--P-MLAHPL
SVI-SSVGNEGQG-APQ-----PSHSDFHQKLTE-DVRTTDRGRQAF--QSITHRNKDKV
GQSE---TLV-DNRCSPEVP----RRQSGDGHEPRNKNVYSSDRVEMIQVQKTVEKNLEH
SFMSNMS-----------R----EIFKANELCALKSQSCDISTTRKVENSQR-TNVKMN-
KVGNTLTT-QCP-S-PKTSVRQDSKLSDLEKQLITELKFKLESQKHSQAQCCPT------
----------------------------------DVPLTSHSLPSKL-SLTHAQGISTGA
TAAS-QVPRVR---LENSGVS--MEQ-WQDPS--KR--ALW-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MCQDN--NF-PSTAKR------MSPLGSKAGE
YRSGD-SEVGTSKTRKKSHPIEDR-ELK----DTFPS-WSQDEQLPPES--YFRKKMRQF
FQWIN-SKRKIK-AQGSPQQKAKFKS--TFV---------QH-QASVESASGF-VSYGHP
E----AQELMMAIGKILEEKLACMLESE--------------ASEFRQHKKELQTQRESD
KGH-AS-S---YRAVLDPQQKGWASTKSSNQEAVSAD-QSCLTSVRQNRDMITQPQK-VA
FEN---------------------------------------------------------
------------------------------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLFPYFSYLRCDDP--------
--------------------PSPSPGKRNRARGRPRGR------MKN-------------
---------------------------------------------HSL----RAC--RPR
LRG-------LE-ELWNLFS-QLQ------------------------------------
---------SLLGP---LLDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------ASRSS---HEPMEDTAP-M-------LSPLASPD PR----TK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
APEPS---------LPPESP-----SPEPPALFPHPPHTSD-------S--PSPPKAFPA
PPLR--D--------------------------------------------STLIIPSHC
DS-VA--LPLGAVP-----QSLSPCK-----DLTAS--VPAISGLG-GS-NSQVSA----
--------FS-WWQETTR---TWC-----------VFNSSVQQDHL--SRHP-PE-----
----TCQMETG--S-PFLLNS-DGQNVM-GIQV-I------ER-------AKVNISE-E-
KE--NDGSFPKQMS-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
PTTP-------KPFWNMGEN----------------------SK---QLPSA QKLSDPRI
LQ-ESFQKNYSQLFWGLPS-LHSESLVANAW-VTERSYTL--QSPPFLFNGISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PIPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SPIH-----NSGVACPAS-QIKVQALCLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPISPELRRQLEQHIQKWFIQH------R
GN-LGRI-QESLDLMQLRDES-------------------SGTSQA-K--GKPR-----P
W-Q----------------SSTSTGESSKEAQK---VK---------------FQ-----
LERDP--CPRLGQILGQT---------PQNLSR----GM-ESFPG-KVLGM-TSE-ESER
DLR--------KPLRSDSGSD----LLRRTER-NRIENILKAHVGR-KLGQMNEGLIP-V
SVRRSWLAVN---QAF-----PVSNTHVKTS-NLAPPKSGK------VCVNTAQVLPFLE
PCTQQVLGAHIGRLWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CEPGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLREQVLTKASD-MPE----SL
-LASSPACKQFQR-APP-----GIPSWNDHGPLK-APPAAQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSR----AVETRE---------AVPQPRVPLGTRMLANLQA-TSDDVR-
GFEAPGTS-RSS-LLPKMSVSQDPRQLCFMEEVISEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVLPLVTENLAPQVP-QGHLQSMPPGN
MQAS-R----------TRRSN--LGH-R-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQVSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KRQSP--MFPPPHKS-------ENSRKPNLEK
HEERL-EGLRTPQPTP------VRKTEDTCQDEGVQPLP-SKKQPPSIS--HFGENIKQF
FQRVF-SKEKSK-----------PAP--VTA---------E-SQKTGKNRSYV--Y----
SSSAEAQGLMTAVGQMLEEKMSLCHARH--------------ASKVNQHKQ---EFQAPV
CGFPCN-----HRHPFYSEHSRMLSYAASSQQATLKS-QSCPNREKQIRDQQ--PLKSVR
CNNEQWGLR-HPQ-----------LLLPKKAVS-PVSP-----PQHWPKTP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNAP--SPTPWVLDILLTLVFALGL-------FFLLLPYFSYLRCDDPP-------
SPSP------------------GKRKCPVRWRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--A--
------------------LP-GHT------------------------------------
---------NLLEP---HLDKG-GL--------------------SQLSGPDLPGEVGRR
APD-G------ASRSS---HEPIEDAAP-I-------LSPVASPD PR----AK-------
--------------------------HPQDLASTPSPG-PRTTSV------SSLSAS--Q
PPEPS---------LPLEQP-----SPEPPALFPHPPHTPD---PLACS--PPPLKGFPA
PPLR--G--------------------------------------------STLMTPSPE
---GA--LPLGTVP-----QSLSPHG-----DLAAS--VPAIAGLD-SS-VSRVSA----
--------SS-WWQETTR---TWC-----------AFNSSVQKDHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQHAV-GIQV-T------ER-------AKVNIWK-E-
KE--NDGSFTDQMT-----------------PEKH-LNS-L--G-----NLVK-LDAEQD
TTTP-------KPFWNMGEN----------------------SK---QLPSP QKLSDPRL
LQ-ESFRKHYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPVQRDTTLSPLLFQA----QPLS---------HLGPK-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-PLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDIRSV
STPNLPQESL------------TSIL--PENFPVSPELQRQPEQHIKKWIIQH------W
GN-LGRI-QESPDLMQLGDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LEKDP--CPHLGQILGQT---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
ILR--------KPLRSDSGSD----LLRCTER-NRIENLLKAHIGR-RLSQTNEGLVP-M
TVHRSWLAAN---QAF-----PVPNTHVKTS-NLAAPESGK------ACVNTAQVLSFLE
PCAQQVLGAHIVRLRAKHRWGLP-LTVLKPIRCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATSLRKPPMASLRKQVLTKASVHMPE----SL
-LASSPACEQFPM-VPR-----GMPSWNGHGPLK-APSAGQEGRWPS--KPLTCSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRQ---------AVPQPRVPLGTCRLANLQA-TSEDVR-
GFEAPGTS-KSS-LLPTVSVSQDPRKLCLREEVVSEFEPGMATKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHPSENLASQVP-QGHLQSMPTGN
MGAS-LELRDF---TAARRSN--LGH-K-EI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------KNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ESQSV--MFPSTHKS-------ENSRKPYEEK
HEEGL-EGLRTPQVTP------VRKTEDTHQDAGIQLLP-SKKQPPSVS--HFGENIKKF
FQWAF-SKKKSK-----------PAP--VTA---------E-SQKTVKKRSRV--Y----
SSSAEAQELMTAVGHKLEKKMSLCHARH--------------TSKVNQHKQ---EFQAPV
CGVPCN-----HRQLFYSQHSRMLSYAASSQQTTLKS-QGCPNRERQIRDQQ--PLKTVR
CNNEQ-------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPN---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSLT------
------------------EKNNDIQKHQGRARRKRKS-----------------------
------------------------------------------------VTF-KDR--KSL
QKE-------AE-EERKLHS-ILK------------------------------------
SFG-PPVSCSPLGQ---HHDTT-LF--------------------RRLLCPDPVCRVCNR
ATA-D------IQQL-LSWES-LKDAAP-----S---VSPLASSA SG----TE---SSFT
LASTPSATPPEDLILSPRPKPSP------PPPLILSPD-LITTVADLFS-PSPLRDP--L
PPQPVSP---LDSKFPIGHS-----PPQQLPFP-LLPPHHI---ERVEP-SLQPKASLSL
NTIFSFGSTLCQD------ISQAVNRTDSCAHRHEPPTP-TALPP-ED----C--TVTQS
KSN-------LTILKTFP-EMLSLGGS---GGSSTS--APTIKGID-HS-HPASSE----
--------FS-WWQPHAE---DSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
GHSVANIIQPV--N-ISFLSH-DILALL-ERQV-K------RR-------GDFLMWK-EN
GK--KPGSFPTQLR-----------------RNYQ-LNS-S--R-----NMLTSAAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQAPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----HEPPVLPPP----QPLF---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SLHLTQVQSQAQPQ-----CPFPALLPSPL--
-FLIR-----VCGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPALVRK-----SFKVHVPISII--PRDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SNHG----PL
N------------------ISLVEGQRCNVLKK---SASSF-PRSFHERSSNMLSM----
--ENV--RNYQGYSQETA--------PKDHLLH----DP-ETSSD-ENLRS-NSERDLET
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTI--C-------QIKHQ-NLAALVSED------HRVDTSQEMSFLR
SNKQKMLEAHIKSFHMKPILNLS-ISGCCGAFPA--------RSVNP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------HLRK---LAGEG-GS--------------------HLPLGGDPPGDVCKP
APA-K------AHQLHG--KC-MPDLSP-TSL------S------PA----A--------
--------------------------PPA PLASTQSPG-PMTFSEPFGP-HSTLSAS--G
PPEPL---------LPLKHP-----ASRPHVVFPLSTQPHG---PLTS---L--------
P-PP-----------------------------------------------DSSLAGLQC
GS-T-----TRPVP-----KSSPLHS----QGPPSP--TRVISGLG-RS-SDPIWD----
--------LY-CWREAAT---TW---GLST-----CSHGKSQPQHL--PDQP-LEASFW-
GDPTPRHVEVG--V-CTFIHP-DVQKLL-ETLI-A------KR-------ALMKMWQ-G-
KE--RERANH---------------------------------------PQMTSLGKEWD
ITTL-------DPFWNVSTE----------------------PQ---QLPRP QQVSDATA
VG-DHLQQKCSQLFWNLPS-FNSESLVATAW-VSSKPSSQ-NNAHSVSLDKAST------
----------SLPGEPEVEASSQLSQA----PPQP---------HHMAQ-PQPFTPAWPQ
--SQPP-PLAGIQTQ-AHL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------S-----PPVPSLPCSSP--
-PQIR-----DCGASHPTT-QEKTESVIPAGK----------------------------
--------------------ENLEWTL------KKR-PK---WKRVLPSLLQKSPTVLSQ
PTAHLPQERP-----ASWSPKSAPIL--PG-VATSPELPEHRWQ-GRSAI-HQEQS---C
GP-PSGF-RASGDLPPPEGEF-------------------PGRPQS-R--AADTQEALLP
S-Q----------------ASGFAGKGRKDVQK---AGFRS-SGR---------------
--------FSGKGCLRSK---------LGPDPSRDR-GS-GRTSV-KFLE--EDKEEAEG
DMW--------RPWKYQSVNS----APRDPDK-EHLENKLQTHLAR-KVGEIKEGWIP-V
PVRRSWLMVK---CAV--P---QSDAHRKPG-KLAS---WR---GGKAHANTSRELSFLQ
PCTQQMLEVHLLRFRVRHRWGPD-LQSLEPINVW---------SGEAQAPPFPQSTFPPW
ASW---ESRDESAANV--------------------------------------------
----------------------------PIFLGKRPQNGPGDNRTTSKSV--L-MVSGAL
-ASAAPEQEEAQR-PLR-----GSQSADTHGRSE-AFPSRHEDRGFS--QPPTCSLVGRT
WQSR---TVLASGKPKPRLEG--SMGSEMPGNEARFESESMSPGDVCSSRA-LQE-----
-----LSIGSQWAR----AEDALEALKVGEEK--PPAWDVTVGASVRTSSGS-IQVDLR-
STGALGTT-DNP-SGSTICVAQDPEQLRLKAQVVNEIALLVQVDSEEQPPGRASGVLL--
----------------QDGAIDLC----LPGCHVDMLPATDRLPAQ-TPLSTPQSVSSKN
TTVS-QGPWAL---LWKGGDS--SGQ-R-EPGSPKAKAPQKS--QKTLGSADKGEA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------RRRPRPGK
QGHGS-KGPRTSEASGRSHSAHTREIGDKQERKYNQPQP-EKRETPPES--HFRRKIGHH
PQGLH-PRKTGA-GWEDVLEKGKPGA--DAV---------Q-SWGSGPAR-LF-MD----
CMVDEAWTISRVVGQILVDKLGLPWGRG--------------PSDVSRHKG---DLHAQE
NV--PS-CG--HRGHCHQEHSREMRAPACSPKATPRG-HHCPVKNRNIRDRDSRW-----
------------------------APPPREPVS-PAGS-----HHHRPRVA--SASG--G
PI--CG--LHRGLAS---------------------------------------------
-

-----------------------------------------MEKILSAL-----NGLSET
---WLTLG---SASYHIDLNYTLLSGLGL-------LLLYISYLI-LKLLIHLL------
------------------GRKKYTPKRQNSI--RRKQR----------------------
---------------------------------------------KAF----KRR--KVG
---PR--D--PE-EGRRL------------------------------------------
----QTVLQ-SPDK---PYDPT-GF--------------------RQALCPDPRCRVCNK
AST-Q------VRHL-LSQAP-LEDGA--ASVSS---L---PSTA PL----IE---ASLA
LPPHFPANRPGHPAPETPPH---------TSRSIHLQN-QITPLDGVSSPPISLSAS--L
SPQAAAS---LNPAVLPAHT-----PRRTLASFPHLHPNAT---QEAQL-ALQAEVPQPP
VESP----------RERSPSVSTAKST-VYEP----A-----------------------
------------------------------------------------------------
---------S-SRPQFTA---ED---QSLT-----NSTHVINHQPPPSDSYA-SQGSYQ-
GLTKAYAVEPG--D-HLSPSP-DVLALF-TKQE-E------GD-------ADGTVYK-LK
RE--KAVSYIM-----------------------P-SNT-S--G-----EISASTAGLEN
LEVS-------HLLGNEKGK----------------------PE---DPHLL QQPSHLKN
SE-DQSEIKDIQLFWGLPS-LHSESLKHEAA-NTGNSYP-----GRDYFN----------
----------KVAQASTGSHSSNLTYS----TPLP---------LPESD-QQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GQI--VPQSQ----IMPDSLANSKAQPQ-----SLAQLLSPSPQ--
-SQLG-----ICGVRFHSL-KNEAQPLTPCEI----------------------------
--------------------QQLEYNL------LQKALQ---SFLGLPTLTETFQESFCP
PPPKISSTRN-----SSKVHAPKTIL--PGDFPLSHTLKRKLEHHLRKRLIQRH-----W
GL-PHRI-LESLSFLSPHSEI-------------------PEAPKP-R--DTHG----LS
R------------------VSLYKFNANTNLPS---SGVSQ-SERSCKKPLESHPP---Q
-EKDI--NVQ-RHRPGIN--------QRDPIQC----KS-CGATK-STVHS-NSETDPEL
Q--------LGNMSGNISK-----ASWVRQCQ-KECEAYLQKHLGK-DTKEISGSERP-S
AVDSSRHSRN---MTQ--PPPETCPRQM------EPLACEE------DALTRHPHSLAIG
PSKEKTLEEHITAFRRRMAFGLP-KRVEESLESD--------LTKAEPSQPFPQLHIQAH
NVSR-ADPAKSSRSL--------RRNTTGDRMGTM----T-----SVPTQQS--------
----------------------------------------------------------PL
PAA-SLVGHSQPASENK-----------KVGVDR-DLSIAPRDREPT--QHWTPRRADKG
DVQQ---SGS-HNRPGPELP----MSPG----GPTHERLASSTNTQGSQEERRSRE---D
GSEAEGS-----------T----ELHKGEQLPGLHPQSTKSLKGTQGLCSPG-S------
-----PVT-ACQ-SPQGMSFLHNSESPDSKSQVSTEVQLNSEGGTHNQVPDLPA------
----------------------------------TPFA-PQEMT------SKPQGPSGGD
MAVS-QVLRVH---MPTVGIS--MES-RQGPWVPAY--VSG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSKNK--DC-LPAARG------LPQLATEAGK
FGGGD-AGLGTSQTTGKGHCVQARAPEETQGLTASPA-LTPK-SQPQEN--QFTSQVKGF
WQRLS-PGKKHK-GQEKSLAKGCSPL--ASG---------KG-TSPIKGRSEF-------
CGNPEAQNCVREPGMVLRKQLGHRHGTVT-PCPQVPVS-PLMGSEGAQQEVPLQAQAEPV
QRLPHL-C---CRGSCSP----VPRAESCSPGQGQTA-PER-----CGPTGKS-------
------------------------------------------------------------
------------------------------------------------------------
-

--------------------------MPRAQLLESN-APIHMENLPFPL-----KLLSAS
---SLNTP--SSTPWVLDIFLTLVFALGF-------FFLLLPYFSYLRCEDPP-------
SPSP------------------GKRKCPVGQRGRPRGR------MKN-------------
---------------------------------------------HSL----RGK--LVP
-------------------P-GSC------------------------------------
---------SLLGT---HLDKG-DF--------------------GQLSGPDPPGEVGKR
APD-G------ASRSS---REPMEDAAP-I-------IYLLASPD PR----IK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LLLEHP-----SPKPPALFSHPPHTPD---PLACS--PPPPKDFTA
PPLW--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLAAS--VPAISGLG-SS-NSQVSA----
--------FS-WWQETTR---TWC-----------Q-------DHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNVV-GIQV-T------ER-------AKVNIWE-E-
KE--NDGSFTNQMT-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
TTTP-------KSFWNKGEN----------------------LK---ELPSP QKFSDPRL
LQ-ESFQKNYSQLFWGLPS-LYRESLVANAW-VTDWSCTL--QSPPF-FNQISN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-SQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFW----PTPMAQAEAQAHLQ-----SSFPVPSPTFP--
-SPIK-----NTGVACPAS-QNKVQALSLSET----------------------------
--------------------QHPEWPL------LRKQLE---GGLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQH--------------T
GQ-PGRI-QESLDLMQLQDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKETQK---VK---------------LQ-----
LERDP--CPHLGQILGET---------PQNLSR----GM-ESFPG-KVLGA-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-NHIENILKAHMGR-KLGQINEGLIP--
--------------AF-----PMSNTHMKTN-NLAPLKSGK------ACVNTAQVLSFLE
PCTQQVLGAHIV------RWGLP-LRVLKPIQCL--------KLEKILSLCSTQLAGPSS
A--T-CESGAGSKVEV--------------------------------------------
----------------------------ATFLREPPMASLRKQVLTKASVHMPE----SL
-QAS----------SPA-----WIPSWNDHGSLK-APTAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSLR----ARETRE---------AEPQPRVPLATCMMANLQA-TSEDVH-
GFEAPGAS-KSS-LLPRMSVSQDPRKLCLMEEVVSEFEPGMAMKSETQPQVSAAVVLLPD
GQ------------------------------ASVLPHASENLASQVP-QRHLQSMPTGN
MQAS-QGLCDL---MAARRSN--LRH-K-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSP--MFPPTHKS-------ENSRKPNLEK
HEEMY-QGLRTPQLTP------GRKTEDTRQNEGVQLLP-SKKQPPSIS--HFRENIKQL
FQRVF-SKKKRK-----------PAP--VTA---------E-SHKTVKNRSCV--H----
SSSAEVQELMTSVGQMLEEKMSLCHECH--------------ASKVNQQRQ---QFQAPV
CGFPCN-----HRHPFYSEHIRMLNYAASSQRATPKS-QSCPNRDRQIRDQQ--PLKSVW
CNNEQWA------------------------VS-PVSP-----PQHGPKIP--GASS---
-HHHHC--PRHCLLRGG-I-----------------------------------------
-

-----------------------------------------MEKILSAL-----NGLSET
---WLTLG---SASYHIDLNYTLLSGLGL-------LLLYISYLI-LKLLIHLL------
------------------WREKYTPKLWEKG---KKRR----------------------
---------------------------------------------QTL----KGG--RAC
---QR--E--AA-QRREL------------------------------------------
----QTTQPSSLEE---PSEAS-CN--------------------ELPLHRDPLLPVCDR
S-G-N------ISHQ-LSQDH-LKDGK--ASYLC---V---ASTVPG----TE---ASFV
LSSLLTGNQAGHSAPALLPEPLP------LAPSILSPN-CFAPLEGFYS-ATLLHDS--L
TPESTLP---LNPSLLPDPT-----PPYPLASFPLPT-REV---QKSEV-VFQLETMRSL
VDRL----------NEMPTNVPPAQGT-GCVRQTMPE-----------------------
------------------------------------------------------------
---------A-PQQQPAA---DN---QLSS-----DSKN---QYLP--APHV-PQVPLQ-
GDTRACHVEPG--Y-LFFPNS-NAVKLF-QRLD-K------KV-------SDFLMVK-GE
QE--EW------------------------EEE----ED-K--G-----CFIKSPSSSEK
LLSGETSGEPQDFVASHSSS----------------------SK---GKLTHQPLPHSKT
FE-DHEELQSSLLFWGPPS-LHSEALSPTTT-NAYDRSS-----ALVCFN----------
----------SMAEASIADYSHGCMLP----TPLH---------AY--Q-PQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TWLQTEPQSH----PQRDPPAELQPQP--QPQSRVSILTF-SHQ--
-SEPR-----DCGVHFHRP-QGDEQLLSSSEM----------------------------
--------------------QCLEYNI------LKKEQE---RVWGLPLMVKKSKYTFCP
SPPKVLLGSR-----SSKACTPRPIL--PGDFPLTSELQKKLEHHLRKRLIQHR-----W
GL-PDRI-DKSLSLMSPQSEL-------------------IDFSES-K--KNRG----LS
W------------------ITFFKYQGNKDSQV---LSGGS----SRNRMPRRHSL---R
-ETRV--KER-TYSQDRG--------HNDQSWG----NNFQEASQ-NSVQS-HLKTHRKS
R--------MGRQPPRFSS-----PSQVKQYQ-RGIEKALEKHLNK-KIREISRGEIP-T
TVDRSRHSVNMANIAQ--PPPETSPKRM--K-DLAPMACKE------HMLTRHPHSLALS
PSKEKMLEEHITTFRRRMAFGLP-QRVEESLESY--------STKAEPSQPFPQLHVQAH
NVSR-ADPAKSSRSL--------RRTTTGDRMGTM----T-----SVPTQQR--------
----------------------------------------------------------PL
PAA-SLVGHSQPASENK-----------KVGVDR-DLSVTPRGREPT--QHWTPRRADKG
DVQQ---SGS-HNRPGPELP----MSPG----GPTYERLASSTNTQESQEERRSRE---D
GSEAEGS-----------T----ELHKGEQLPGLHPQSTKSLKGTQGLCSPG-S------
-----PVT-ACQ-SPQGMSFLHNSESPDSKSQVSTEVQLNSEGGTHNQVPDLPA------
----------------------------------TPFA-PQEMT------SKPQGPSGGD
MAVS-QVLRVH---MPTVGIS--MES-RQGPWVPAY--VSG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSKNK--DC-LPAARG------LPQLATEAGK
FGGGD-AGLGTSQTTGKGHCVQARAPEETQGLTASPA-LTPK-SQPQEN--QFTSQVKGF
WQRLS-PGKKHK-GQEKSLAKGCSPL--ASG---------KG-TSPIKGRSEF-------
CGNPEAQNCVREPGMVLRKQLGHRHGTVT-PCPQVPVS-PLMGSEGAQQEVPLQAQAEPV
QRLPHL-C---CRGSCSP----VPRAESCSPGQGQTA-PER-----CGPTGKAKRVETSP
VLA-------S------------PPKSSL-------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYIET
---GLIPD---SHYLDIDPTFICLSGLGL-------FILYLFYVV-LILHSSPS------
------------------EKNNDIQKHQGRARRR---RKSV-------------------
----------------------------------------------TF----KDR--KSF
QRE-------AE-EERKLLS-ILK------------------------------------
SFG-PPVSCGPLGQ---HHDTT-RF--------------------RRLLCPDPVCQVCNR
ATA-D------IQRL-LSWES-LKDAAP-----S---VSPLDS AGSA----TE---SSFT
LSSTPSAIPTEDLILSPRPKLSP------PPLLILSPD-LITSLANLFS-PSPLKDP--P
PPQPVSP---LDSKFPVDHS-----PPQQLPFP-LLPPHHI---QRVEP-NFHPVAGLSL
NTIFSLDSTQCQD------ISQAMNTSDSCAHHYKPPIS-AALPL-ED----C--SVTQS
KSR-------LTILKPFA-EMLSLGGS---GETSTY--APIIKGID-HS-CPASSE----
--------FS-WWQPHAK---GSF---SS-----NFVPSDFMEELL--TLHS-SEASLG-
WHSVANVIQPV--N-ISFVSH-DILALL-EREV-K------KR-------CDFLMWK-EN
GK--KPGSFPTQLR-----------------QNYQ-LNS-S--R-----KMLASIADKHD
MVEF-------FPFGANKGK----------------------LE---GQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGRSS-----MFVFFNGITN------
----------TSIF----HKFPVLPSP----QPLS---------LPNTQ-AL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVQFQAQHQ-----SPLPVLLPSPP--
-FLIR-----ICGVCLHRP-QKEAQSLTPSEI----------------------------
--------------------NLLECNV------LQKVQE---SVWGLPSVVKKSQEDFCP
PAPNLALVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
GL-PRRI-HESLSLLRPQSKI-------------------SELSVS-E--SIHG----PL
H------------------RSSVEGQSLNVLKK---FGSII-PRTLHERSSNMLSL----
--ENV--GNYQGCSQETG--------PKNHLLQ----DP-ETSSD-EDMKS-NAERDLDT
Y--------MMHLSGNHS--------GESLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLAEESHSQIKHR-NMAALVSED------HGIDTSQEISFLG
SNKQKMLEAHIKSFRM--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

--------------------------LPRAQLLESN-MPIHMENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPCLSYLRCGDRP-------
SPSP------------------GKRKCPVGWRGRPRGR------MKN-------------
---------------------------------------------HSL----RAG--RES
PRG-------PE-EIWDLLS-QLQ------------------------------------
---------SLPGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-E------ASRSS---HEPMEDAAP-I-------LSPLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PVTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPKPPALFPHPPHTPD---PLACS--PPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--LPLDTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-WWLETTR---TCC-----------AFNSSVQRDHL--SRHP-PE-----
----TCQMEAG--S-PFLLSS-DGQNII-GIQI-T------ET-------AKVNLWE-E-
KE--NVGSFTNQMT-----------------PEKH-LNS-L--G-----NLVKSLDAEQD
TTTP-------KPFWNVGEN----------------------SK---QLPGP QKLSDPRL
LQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLEPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIK-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRKQVE---DRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLQDES-------------------PGTSQA-K--GKPR-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LEKDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ESER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
RVRQSWLAVN---QAL-----PVSNTRVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQVLGAHIVKFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------ATSLIKPPMASLRKQVLTKAFVHMPE----SL
-LASSPACKQFQR-ALR-----GIPSWNDHGPLK-APPAGQEGRWPS--KSLMYSLTGSS
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEASGTS-KSS-LHTRVSVSQDPRKLCLMEEVVTEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLASQVP-QGHLQSMPTGN
MRAS-QELRDL---MAARRSN--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RNPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPSHKS-------ENARRPNLEK
HEERL-ERLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSIS--HFGENIKQF
FQWIS-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
SSSAEAQGLMTAVGQMLEEKMSLGYARH--------------ALKVNQHKQ---EFQAPV
CGFHCN-----HRHLFYSKHGRILSYAASSQQATLKS-QGCLNRDRQIRNQQ--PLKSVW
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVCP-----PQHWPKTS--GASR---
-HHHHC--PSHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENFFSL------RSTGTS
---WLSSG---PTSWVIDAIFAFLCGLGL-------FLLLLPCFQ-SNSSLSPA------
------------------KKYRNIRKHQVELRRRSK------SKKKSG------------
----------------------------------------------AL----KAC--RNC
LKE-------LE-GARSLIS-LLQ------------------------------------
---------SCLGR---LPDKG-GF--------------------HQLLCQDIPGEVCKA
VPA-G------AHQPCR--EP-MDAAAP-TMS------L-LATPV P--------------
--------------------------L---TQRPLLLG-SMTSSVSVHS-HSFLSAS--S
PPEPF---------LPLNSL-----LPQPLALSPLPPCPLN---PEAC---PPPLRTSSA
PQSP-----------------------------------------------DSILTLPQC
DS-LA--FPLSTIP-----QR-SSHTPW----SASA--VPAISGLG-H-SSCPISA----
--------LS-WWHTAA---KAL---CLST-----SSNCKSQQEHL--SHHS-PEASFW-
GNPTNRQVGAA--S-PSLLSS-DNQKLL-EIQV-T------KR-------VKVKIWK-E-
KE--KDESYPKQIS-----------------PDYH-LNS-L--G-----NMLKSLSPEQN
-TSL-------QHFWSTKGK----------------------PE---QLPGH QKLSYPKV
LG-HHLQQKYNQLFWGLPS-LHSESLVATAW-ISEGSSVP--QSSSFLFNGISS------
----------ACPTQMQAKLSPLLSQS----QPPS---------QLEFQ-SQPLVSSVP-
-QFQPP-SLAQ-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ILTQDHRQ-----SSLPILSPS-P--
-PQIE-----ACEVSCLIA-QDKSQFLIPPEI----------------------------
--------------------QHPEWPL------LQKQLE---SGWALSSVIKRSQEVFSV
FTSNLPEDSW-----A------VSLL--PENFPISAELRKQLEQHLQKWLIEHR-----W
EL-PRKIQ-ESLELRQLQGEL-------------------PGTCQA-K--GKHG-----P
S-R----------------PSACAGKSNKDTQK---VEF-----------QLSQGM---G
--K------GLGYILGKV--------PK-DLSR----DS-ESSLM-GFQEV-SSGES-EC
---------DLGLSMSDSGSD----LLKSLD--KNLENILKDHLGR-KLGKISGSLIP-V
SVHKSWLAVN---HAF--PKS---NTHKEIR-NLGILKCWG------PYVNTSHRVSFLN
PDIQEVLEAHIIRFWVRHRWGLP-LKALKPINLF--------KLKKVQPLSILQFAFNPS
ATC---VSGTASIIKF--------------------------------------------
----------------------------AESLGRPSQACLGKKVVAEESG--L-TLEKPL
-LAPSPMYEEIQR-ALV-----RTPSDDNQGSSK-ASLTGQDSRPPS--QSFTLNLMGRT
PQSD---SAEWAEKSS--LEL--SPSSAMAGNEPREENEDWASQDPCHRVA-MLK-----
-----INLGPQYLR----SEKAREAVEAKPPTL---QPRPILGTNVLTKPQT-INAHMG-
GLD------TSK-KLSRMSAIQDPGESCLNTEV-SEFKSKLKIKPENQSQDCPT------
----------------------------------HVILAVDNLASQAPQCY-PQTVPTGD
KIAS-QMLYGL---MANQRSC--LRQ-Q-DPMNSGLQDSW--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQSK--MTASTYKR-------EDYRRPNSGT
NKEQF-EELRTSQAESMSHLSPVRGIVDSVRNRCIQFLP-EKKQGPPEN--LFRKRMRHF
FQWIF-PNRKVK-GQ-NTMQKCKPVI--ASA---------QS-QGPVKSRSIM--A----
NETAEAQALMTAVGQILEEKMAIHHGLH--------------GTKLNEHKQ---ELQAPV
CG--CF-CY--HRVPFYPVHGR-MSYTAHSHQDTSNG-QSSSFKERQVKHRQSLKS--VR
FEDEQLDPR-HLP-----------SLPPKKTLS-PVSP-----CQYRPRML--GAPG---
-YHQHC--PRHCLLQAS-LFGRS-------------------------------------
-

-----------------------------------------MENLPFPL-----KLLSAS
---SLNAP--SSTPWVLDIFLTLVFALGF-------FFLLLPYLSYFRCDDPP-------
SPSP------------------GKRKCPVGRRRRPRGR------MKN-------------
---------------------------------------------HSL----RAG--REC
RRG-------LE-ETSDLLS-QLQ------------------------------------
---------SLLGP---HLDKG-DF--------------------GQLSGPDPPGEVGER
APD-G------ASQSS---HEPMEDAAP-I-------LSLLASPD PQ----AK-------
--------------------------HPQDLASTPSPG-PMTTSV------SSLSAS--Q
PPEPS---------LPLEHP-----SPEPPALFPHPPHTPD---PLACS--LPPPKGFTA
PPLR--D--------------------------------------------STLITPSHC
DS-VA--LPLGTVP-----QSLSPHE-----DLVAS--VPAISGLG-GS-NSHVSA----
--------SS-RWQETAR---TSC-----------AFNSSVQQDHL--SRHP-PE-----
----TCQMEAG--S-LFLLSS-DGQNVV-GIQV-T------ET-------AKVNIWE-E-
KE--NVGSFTNRMT-----------------PEKH-LNS-L--R-----NLAKSLDAEQD
TTNP-------KPFWNMGEN----------------------SK---QLPGP QKLSDPRL
WQ-ESFWKNYSQLFWGLPS-LHSESLVANAW-VTDRSYTL--QSPPFLFNEMSN------
----------VCPIQRETTMSPLLFQA----QPLS---------HLGPE-CQPFISS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------TPQFR----PTPMAQAEAQAHLQ-----SSFPVLSPAFP--
-SLIQ-----NTGVACPAS-QNKVQALSLPET----------------------------
--------------------QHPEWPL------LRRQLE---GRLALPSRVQKSQDVFSV
STPNLPQESL------------TSIL--PENFPVSPELRRQLEQHIKKWIIQH------W
GN-LGRI-QESLDLMQLQDES-------------------PGTSQA-K--GKPS-----P
W-Q----------------SSMSTGESSKEAQK---VK---------------FQ-----
LERDP--CPHLGQILGET---------PQNLSR----DM-KSFPR-KVLGV-TSE-ELER
NLR--------KPLRSDSGSD----LLRCTER-THIENILKAHMGR-NLGQTNEGLIP-V
RVRRSWLAVN---QAL-----PVSNTHVKTS-NLAAPKSGK------ACVNTAQVLSFLE
PCTQQGLGAHIVRFWAKHRWGLP-LRVLKPIQCF--------KLEKVSSLSLTQLAGPSS
A--T-CESGAGSEVEV--------------------------------------------
----------------------------DMFLRKPPMASLRKQVLTKASDHMPE----SL
-LASSPAWKQFQR-APR-----GIPSWNDHEPLK-PPPAGQEGRWPS--KPLTYSLTGST
QQSR---SL---------------------------------------------------
--------GAQSSK----AGETRE---------AVPQCRVPLETCMLANLQA-TSEDVH-
GFEAPGTS-KSS-LHPRVSVSQDPRKLCLMEEVVSEFEPGMATKSETQPQVCAAVVLLPD
GQ------------------------------ASVVPHASENLVSQVP-QGHLQSMPTGN
MRAS-QELHDL---MAARRSK--LVH-E-EP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------RKPNCQGSC-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KSQRP--MFPPIHKS-------EKFRKPNLEK
HEERL-EGLRTPQLTP------VRKTEDTHQDEGVQLLP-SKKQPPSVS--PFGENIKQI
FQWIF-SKKKSK-----------PAP--VTA---------E-SQKTVKNRSCV--Y----
SSSAEAQGLMTAVGQMLDEKMSLCHARH--------------ASKVNQHKQ---KFQAPV
CGFPCN-----HRHLFYSEHGRILSYAASSQQATLKS-QGCPNRDRQIRNQQ--PLKSVR
CNNEQWGLR-HPQ-----------ILHPKKAVS-PVSP-----PQHWPKTS--GASS---
-HHHHC--PRHCLLWEG-I-----------------------------------------
-

-----------------------------------------MENILSSL-----NGLTET
---WLTFG---SASYHIDLNFTLLSGLGL-------LLLYICYLI-LKLVLSSL------
------------------WKKKYTQKVRNCR---RKPR----------------------
---------------------------------------------KA-------G--DHL
---KV----------GLE------------------------------------------
----PLPSCSPLGE---PYDAT-LY--------------------DQLLHPAPLYNVCPR
ATC-K------VSHL-FSQAT-LEDGV--ASHFC---L---ASTA PG----TE---ASFI
LPPQLTANQPGHSAPPIPHGPLP------LGPSILSPN-HFAPLGSLLS-STPLGDF--L
IPEPMPP---LNPKFLPAPT-----PPYALASFTLPT-KEP---RESEV-VLQLKTTISV
VSKP----------SEVSIRVPTTRGI-GYGSRPGW------------------------
------------------------------------------------------------
---------D-SSQRPAA---DG---PLSS-----DVAYAFNQHLP--EPHA-LQ-----
-----GDLEPG--N-PLPPNS-DALAQL-KRQD-K------TG-------GDFLTTK-DE
------------------------------------EKN-Q--E-----CFRKYSRSLEK
LSSACSLTKPQDLATSHSTS----------------------SK---AKHRH QQVPHLKT
SE-DHAEPKPPQRFWGPPS-LHSEALQPPTT-ASPDRSS-----TFVGFN----------
----------SMAEASGADSSPAVTLP----TPLF---------VTKSQ-SQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TWLQPLSQSH----SQHDPPAESQAQPQ--PNPLTSVLTF-SPQ--
-TQVR-----VCGVRFHRP-QKEGQPLGPSEK----------------------------
--------------------QYLEYNI------LKKRQE---RVWGLPSVVQKSQDAFCP
PPPKRLLASQ-----SFKSYSPRPIL--PGDFPLTNELRKKLEHHLRKRLIQHR-----W
GL-PHRI-NESVSLTCPQSQF-------------------VDFSES-R--KSHG----LS
W------------------ISLYKHRGSRESHT---IVLSG-SGSFHNGTSEYHLL---E
-ETEV--KAQ-TYSQDAG--------KKDHLQS----N-FQEAPA-NSLQS-DLKTDQER
H--------AGGQSGQLSN-----PSRVNQCQ-KRIENALAEHLSR-KTKEIRESQIP-S
SVVRSWHSVN---LAQ--PPPETPPRQV--K-DVAPLAGEE------DPLGKHQRSLSLS
PSKEKMLEEHIKTFGRRMTFGLP-QRVEESFESY--------ATKMEPSHLFSKFHVPSH
TVSG-VDSGQASRFL--------PRNPSGDRLGTM----N-----FMPIQEV--------
----------------------------------------------------------PL
PAS-SPVRQMQPTSENK-----------KVFVDK-DLSIAQRGRAPI--QPWTPSMVDKG
SLPQ---PGS-DTRHSPELP----MRPD----GPTDERLASSTNTQGPQGARMGWG---G
GSTAEGS-----------T----ELLKGEELPGLHPQSTKILTATQGTYSPG-S------
-----RVT-PCQ-SLQGTA-PYNSETSECRGQVPRGVVLHSVSGQPIQVAGLPE------
----------------------------------VPSA-SKGMT------SKRQGPSSGD
MAAS-QVLQVH---LSTVGVS--MEP-RQGPWFPAH--VSG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQNR--EC-PPAAKG------VSPLAAEAGK
LGGGD-AGLGTSQTRGKEHSVQAGAPEETHGHTSSPA-LSPK-AQPPEN--QFTNQVKCF
VQWMS-PGRKHK-GEERSLAKGSSSS--PSV---------KG-TSLIRGSYEF-------
CGNTEAQRCVRNPGVVLRKQLGHRLGAVI-PCPQAPVPPPVLGSEGTQREVQVQAQAEPV
QRH-HS-C---CQAACSQ----VRGAGSCSPGQGQAA-PER-----CGIAGKA-------
------------------------------------------------------------
------------------------------------------------------------
-

-----------------------------------------MENILCFL-----NSYTET
---GLSPN---SHCLDIDPNFICLSGLGL-------FILYLFYVV-LTLYSSPT------
------------------EKNNDIQKHQGRARRR---RKVG-------------------
----------------------------------------------TFKGN-VNW--KSF
QRE-------EE-EERKLLS-LLK------------------------------------
SFG-PPVSCSPLGQ---HHDTN-HF--------------------RRLLCPDPVCRVCNR
ATA-D------IQQL-LSWES-LKDAAP-----S---VSPLASSA SA----TE---SSFA
LASTPSATPPEDLILSPRPKPSP------P-------------------------DP--L
PPQPVSP---LDSKFAIDHS-----PPQQLPLP-LLPPHHI---ERVEP-SLQPEASLSL
NTIFSFGSTLCQD------ISRAMNPIDSCARHHGPPIP-SALPL-ED----C--TVTQS
KSS-------LTILKTFP-EMLSLGGS---GGSSTS--APTIKGID-HS-HPASSE----
--------FS-WWQPH---------------------------ELL--TLHS-SEAFLG-
GHSVANLIEPV--N-ISFLSH-DILALL-ERQV-K------KR-------GEFLMWK-EN
GK--KAGSFPKQLR-----------------PNYQ-LNS-S--R-----NMLTSIAVKHD
LAES-------FPFWASKGK----------------------LE---WQHIH QQPPYSKC
FE-DHLEQKYVQLFWGLPS-LHSESLHPTVL-VQRGHSS-----MFVFFNGITN------
----------TSIS----YESPVLPPP----QPLS---------LPSTQ-PL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PLPQTLPRGQ----SPHLTQVKSQAQPQ-----SPFPVRLPSPL--
-FLIR-----ICGVCFHRP-QNEARSLLPSEI----------------------------
--------------------NHLEWNV------LQKVQE---SVWGLPSVVQKSQEDFCP
PAPNPELVRK-----SFKVHVPISII--PGDFPLSSEVRKKLEQHIRKRLIQRR-----W
DL-LRRI-HESLSLLRPQSKI-------------------SGLSVS-E--SIHG----PL
N------------------ISLVEGQRCNS-------ASSF-PGSFHERSSNMLSM----
--ENV--GNYQGYSQETA--------PKDHLLH----DP-ETSSD-ENLRS-NSERDLET
H--------MMHLSGNDS--------GVRLGQ-KQLENALTVHLSK-KFEEINEGRMP-G
TVHSSWHSVK---QTM--SLPEKSQSQIKHR-NLVTLVSED------HCVDTSQEISFLS
SKKQKMLEAHIKTFRMRMLWGLP-LKVLESIEIF--------KSKADLSTSFSHFDLPSS
ATF---ISRGDSKDGVSKSRRRS--TFQGEKLGTT---------SSVPILDRPHPVSSPV
GQEGQGTLRRQFSDTDHDLIETDSKDGASTSLRRGTTDFQSEKLESTSSF--P-ILGHSY
-LVTSPVNQEKQG-TLR-----REFSDTDNDLTE-SVRTTEDGRQTF--LPPPHSIVDEV
SQKQ---TVL-ASRCSAEL-P---IMQAGAGCESWDKRKSSFHNVDRLQGSRKT------
FPV---------------TS------------ALQSQTRNNLTTSKSGSCSL-ANVKAS-
TS---NET--E-IFPPRISVPQDPKSPYLKNQMLSQLK--LVQRKHSQPQSHFT------
----------------------------------DMSFALDNLSSKDL-LTNSQGISSGD
MGTS-QVVHVH---LEDRGIR--VAQ-KQEPRVPTCV--LQ-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------KCQVK--NFPPAVNR-------VSPVRPKGGE
LDGGD-AGLGTSQRRRKKLPVHNKTSGEVLGSKSSPTL---KTQPPPEN--LSRKWMKTF
LQWFNKPSISYE-EQESSWEKGSSLL--SCV---------QN-IGRVT-RAAF-------
TGTTEAQKIRKDTREFLEEKLGHRHGIDI-TCPREPLSFPVGL-GKAQHNPEVHVRAESV
QGYACN-----YRAPSCK----VTRTKSCSQQAIFVG-QNYPTRIRQIIDKDRQPQKVEA
FKGKILCQS-HPQ-----------SMPHRKPVPHPNPTCRRQVSLVCPAVP-TSAKS--P
VFSDVPFLTGQKMLPKH--FQG------GKFPPTK-------------------------
-

Query Results

"ENSGT00530000063191"

ENSGT00530000063191