Query Results 

----MAGPGGWRDKEITDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKSIGFGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRSQSLKEDWIAYICREILQGLAHLHEHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRANGRRNSFIGTPYWMAPEVINCDEDPRH
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFTEK
CMIKNFLFRPTSANMLLHPFVRNIKNEKHVVQSLTKHLKGIIKKRQKKGRI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGI

PF00069 // ENSGT00920000148966_3_Domain_0 (29, 289)

FSLDKAIGLGTYGRIYLGLHKT--AFTAVK--
---MNARKTPLPEIGKRVRVNKYQKSVGWRYSXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXMVMELCAAGSVTDVVRLTKNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTQNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXGSSCTQELLRMPTSSRCRPLRVLHRERSQPRWFPDQVEPQVQALKQLQGAARVLTPLQAP-------QGQAPAPPQLHQA-ACVFMPLQAQVKFKVPWPLQMQIKTPPRFQKAAQVFMPLYSQLKGRRSVQGQA---KVVKEQ--QAQTQVSQQPQDL---DQVPEEFHGQDQVPEQQQREGQAPDQQQGQQQAPEQQLEQ---NPVPEEPELEXXXXXXXXXXXXXXX----XXXXX------XXXXXXX--------------------------------XXXXXXXXXLLL----HLDTQ--VLILVEE--PTGEIPQAQSWALEPQQILSSV--------QALIERL-----------SRDLLQAPGAHNS--KPLGPLQTLMENLSAN----------MFYSQPEQARK-KKSKVSSLRQALVKRLSPKRFRGRLSRRSEEFQ--DLETLRRR-RQYRWEDIFNQHEE-----ELRQVAN-DNEDESSDNDEVLHSIQAE--VQIEPVQQHVANPME-----NEVQERSAP---RPCNQDR------AHRVT----FSP----------------------SIP-QEA-VLE-------------QAPRP-IDV-------RQR-SAPNPQNCPAASESS-SEEESPVVRRRSQSSPPYSTIDQKLLMDIHVPDGFKVGKISPPVY--LTNEWVGYNALSEIFRDDWLMPAPVIQ----SPEED--------------------DEYVELYDADANSDGDD------------------DSNDAYEDTYDHENE--NFHYQIDQVNEYDEDS----------------------------------NDDDDPQWPXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXX----------X--XX-XXXXXXXXXXXXXXXXXXXX---XXXXXXX-XX---XXXXXXXXXXX-XXXXX---------XXXX-XXXX-------------XXXX-------------------XXXXX------------XX---XXXXXXX-XXXXXVPRDGSEASNA-------D---------EPDHEND-SKDISES--STNNFSASHSS----------------------------PSRGPRRAAAVYLASA--VSYAGLVEVPEEPPKPPSDINVNPLYASAASEKPIIHMYEKEFTSEICCGSLW---GVNLLLGTRSNLYLMDRSGKASITKLIKRRPFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKKRQEDMLKTEEACKAIDKLTGCEHFSVL-QHEETTYI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 289)

FSLDKAIGLGTYGRIYLGLHKT--AFTAVK-----MNARKTPLPEIGKRVRVNKYQKSVGWRYSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMVMELCAAGSVTDVVRLTKNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTQNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSS

ENSGT00920000148966_3_Linker_1_2 (289, 1578)

GXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX---XXXXXXXXXXXX
XXXXXXXXXXXXXXXGSSCTQELLRMPTSSRCRPLRVLHRERSQPRWFPDQVEPQVQALK
QLQGAARVLTPLQAP-------QGQAPAPPQLHQA-ACVFMPLQAQVKFKVPWPLQMQIK
TPPRFQKAAQVFMPLYSQLKGRRSVQGQA---KVVKEQ--QAQTQVSQQPQDL---DQVP
EEFHGQDQVPEQQQREGQAPDQQQGQQQAPEQQLEQ---NPVPEEPELEXXXXXXXXXXX
XXXX----XXXXX------XXXXXXX--------------------------------XX
XXXXXXXLLL----HLDTQ--VLILVEE--PTGEIPQAQSWALEPQQILSSV--------
QALIERL-----------SRDLLQAPGAHNS--KPLGPLQTLMENLSAN----------M
FYSQPEQARK-KKSKVSSLRQALVKRLSPKRFRGRLSRRSEEFQ--DLETLRRR-RQYRW
EDIFNQHEE-----ELRQVAN-DNEDESSDNDEVLHSIQAE--VQIEPVQQHVANPME--
---NEVQERSAP---RPCNQDR------AHRVT----FSP--------------------
--SIP-QEA-VLE-------------QAPRP-IDV-------RQR-SAPNPQNCPAASES
S-SEEESPVVRRRSQSSPPYSTIDQKLLMDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRDDWLMPAPVIQ----SPEED--------------------DEYVELYDADANSDG
DD------------------DSNDAYEDTYDHENE--NFHYQIDQVNEYDEDS-------
---------------------------NDDDDPQWPXXXXXXXXXXXXXXXXXXXXXXXX
----XXXXXXXXXX----------X--XX-XXXXXXXXXXXXXXXXXXXX---XXXXXXX
-XX---XXXXXXXXXXX-XXXXX---------XXXX-XXXX-------------XXXX--
-----------------XXXXX------------XX---XXXXXXX-XXXXXVPRDGSEA
SNA-------D---------EPDHEND-SKDISES--STNNFSASHSS------------
----------------PSRGPRRAAAVYLASA--VSYAGLVEVPEEPPKPPSDINVNPLY
ASAASEKPIIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLW---GVNLLLGTRSNLYLMDRSGKASITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKKRQEDMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYVWAPKSFDENTAIKVICVDQSADSEGD
YMSYEAYIRILAKIKAADPANRFKRPDELLHLLKLKARNLKTT--NQVTVDLAIGSEKSL
KIFFSSADGYHIIDAESEVMSDVTLPNNPMKISLPQSI-VILPDCLGFGMMLTFNAEALS
VEANEQLF-KKILEVWKDVPSSVAYECTQRTTGWDQKAIEVRSLQSKVLENELKRRSIKK
LRFLCSRGDK-LFFTSILRNHHSRVYFMTLGKLEEFQNNDGV

----MAGPGSWRDKEVTDLGQLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKAIGLGTYGRIFLGIHEKTGSLVAVKVM
----SARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGA
FFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQ
VIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRC
SYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMEN
CMIKNFLFRPTSGNMLLHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VHDIKNERRVVESLTKHLTGIIQKRE--KKGIPVAFEGEE
AAKEQYIT---RRFRWPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDQEDPQDQELQ
QLQKAAGVFMPLHSQDNTSKLFPKQVEVAPYLRGA-AQVVMPVLV------------QVE
APPQVSKAAQMLKSLPTQDNKATSPEVQA---PVAEGQQAQHEALETEQPKDL---DQVP
EEFQGQDRAPEQ-PRQGQPAEQQQIHNPVPEQPPEE---DREPEQAEVQEEAVEPPQA--
EIEDKEP-EVVQV------HAQVLLP--------------------------------LL
SQNRHVLLPL----HLDRQ--LLIPVGE--QNEEVPRAQVWDLEASRAVGAV--------
QALIEGL-----------SRDLLRAPNAFVT--KPLGPLQIFLENLCTD----------G
FYSEPEPTQK-KKSKVASLRKAIAKRLRPKRFRAKALWRLEDFESSDVETSRRR-RHRRW
EDIFNQHEE-----QLRRVEN-DREDDSSDNDEVFHSIQAE--VQIEP---HAANPAG--
---NEVHERSAP---MPCNRNR------THRVK----FSP--------------SVGEEE
P-SLE-EAQ-PQQ---------------QQS-MNI-------RPRN-CLNPQNFQAQSDS
S-SEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFWDDWIMPTRPAR----PPEED--------------------GDYVELYDADANANG
DEE-----------------VANGAYEDPRDGANGHDDMNNQLVQANGYEGHGAAGYNG-
-----------------G-----DVGGNHGAAFNGPRANYPRAGILKNGRNDGRAL----
---------NRGAF----------GAFGDNAARAFHG--AAGEAGAAFGNH---GANRGN
GRG----NRNREANGRNEENGAF-------------------------------------
------------------GR-D------------QH---VFP--EF-EHEESDRGT--ET
SDSIALEITS-----------FDGEQ--N-SGRPVSSTTMGFPIGRSS------------
----------------PRG-------SDFGS-----------------------------
-DISYNSPILHVYEKDFSSEVY

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTQSHLYLMDRSGKAEIVKLIKRR
PFRQIQV-VEQLNLLITISGKKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKA
IDKLIGCEHFSVL-QHEETTYIAVAVKSSIHLFAWAPKSFDENTAIK-------------
------------------------------------VF--PTRELKPLTVDLAVGSEKTL
KIFFSSANGYHIIDAESEVMSEVTLPNN--------NV-VILPDCLGLGVMLSLNAETAS
EEANEQLL-KKILDVWKDIPSSVAFECTKRITGWDQKAIEVRSLQSTILENELKRRSIKK
LRFLCARGDK-MFFASTLSNDHSRVYLMSLGKLEELHRSYAV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDELDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAATGDQEEHAANIGS
ERKGSGGDGDKAVIRTSEESGAL---------GPNGEENCS-------------ETGG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-STQSDFSANHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEINVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGSYGRIYLGLHEKTGEFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMEFCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHTAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGVPPLCNLQPLEALFVILQESAPTVKSSGWSRKFQNFMEK
CMIKNFLYRPTSGNMLHHPFVQNIKNERHVVESLTKHLTGIIKKRQKKGNLKPNDHSAIF
P-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------------

PF00069 // ENSGT00920000148966_3_Domain_1 (46, 321)

GLHEKTGAFTAVKVM
----NARKXXXXXXXXXXXXXXXXXXXXXXXXDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKMSPAGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLRHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1580)

VQNIKNEGHVVESLKKHLTGIIKKRQ--KKGMPLVFEKEE
AIKEQYTV---RRFRGPSCTHELLRLPTSSRCRPLRVLRGEPSQPRWLPDGDEPQVQALH
HLQGAARVFMPIKAQSTAPKPVQGKAQAPRRLPGAAAQVLMPLQPQMKAKTSKPM--QLR
PPPRLHRAAKRFRPLQAQFKVPRPLPVQP---QVPKEQQVQAQTQKSEKPQDL---DQVP
EEFQGQNQAPDQQQRQGQQAGQQQRPNQVPGEQMAP---NQAPEQPEVQQQASGPAQA--
DAGAQAP-ESLRV------HAQVCLP--------------------------------LM
SQNHHVLLPL----HLDTQ--VLVPVEG--KSERSPRAQAWPLEPPQAVGPV--------
QALVEGL-----------SGDLLRAPDSKNS--KPLGRLQTLMENLSSN----------T
FYSKPEQVQK-KKSKVFSLKQALTKTLSPKRFRAKFTQKSEEFELSDLEGRRQR-RQRRW
EDIFNQHEE-----ELRQAANXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXX--
---XXAQGKSAS---VPGNQNR------VHRVT----FSS--------------VS----
-------QV-SLE-------------QAQKP-IDI-------RPK-TSQNPQNCPSSSES
S--EEESPVTRRRSQSSPPYSTIDQKLLVDVHXXXXXXXXXXXXXXX--XXXXXXXXXXX
XXXXXXXXXXXXXXXX----XXXXX--------------------XXXXXXXXXXXXXXX
-XXXX---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDD---H-
-----------------KNDTADDEGDNRDNARSLPRASYNVGSFVGRFKQDGTVEN---
-------DGIEGAC----------GGYGSHVDNKNPGEGTSSQDDEDLNDLEVCGINMGK
GIRGMEGNGDKQVSEINEASEDF---------KLNGGQNSS-------------KKDG--
-----------------PVS-K------------RQ---TSQ--DT-EHPQKESSGKSET
SNG----TAPL---------VPHDEND-SMVISEASA--ESLSASCSS------------
----------------ASNGSL-GTNGDFASA--IXXXXXXXXXXXXXXXXXXXXXXXXX
--XXXXXXXXXXXXXXXXX

PF00780 // ENSGT00920000148966_3_Domain_2 (1580, 1936)

XXXXXXXXX-XXVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGNKNRLRVYHLTWLRNKILNDDPDSNKRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVICIDQSADSEGD
YMSYEAYIRILAKIQAADPVNRFKRPDELLHLLKLKARNLK----NRITTDLAIGS-KRL
KIFFSSADGYYIIDAESEVLSDVTLPNN---IIIPQNI-IILPDSLGIGMMITFNAEALS
VEANEKLF-KRILEAWKDIPSSVAYECTQRTTGWGQKAIEVRSSQSRVLENELKRRAVKK
LRFLCTRGDK-LFFSSTLRNRHSRVYFMTLGKLAELKINHGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTKNQSLKEDWIAYICREVLQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLQHPFVRSIKHERHVVESLTKHLTGIIKKREKKGRINESS-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHSHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRINGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHDFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VQNIKNEGHVVESLKKHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQNGTPRPLQGQAQAPQQLQGA-ARMFMPLQAQVKAKASMPFQMQMK
APPRPQRTTCMFMPLQAQVKGPRPQQV--QAQVS-KKQQAQGQPQASGEPQDL---DQVP
EEFQRQDRVPEQQQRHGRVPEQHQRQNHIPEQPLQP---NGAPEQPEVQEQAAEPTQA--
EVEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLVPVEG--QIEWSPQAQAWALDPTQAVGSV--------
QALIEGL-----------SRDLLRAPNAHNS--KPLGPLQILMENLASD----------T
FYSQPEQPRK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEVFELSDLEAHRQR-RQCRW
EDIFNQHEE-----ELRQVAN-DKEDESSDNDEAFHSIQAE--VQIEPLQPYIPDPRE--
---NEVQERSAR----------------VHRVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNPQNCPAASES
S-SEEASPVIRRRSQSSPPYSTIDQSLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGADTDG
DD------------------DSNDAYEDSYDHDNGSDELNDQVDQADVVGEDRDDDDND-
-----------------EVIDDKG--NNPDDASSWPRPSCGRGRSY---KQDGKDGSD--
--------RGEGSF----------SGYGSQRVNRSHGGSAARGDGAAIGDHEEHRANVGS
GRRGKEGNGNEGVSGTNEESEAQ---------ELNGGENCS-------------ETDD--
-----------------PIL-E------------RP---AFQ--EF-EHQLEEAGGRSEA
SNAIAPGAAPA---------VPDAEND-TVDISEV-STESGFSASHSS------------
----------------PSNDSERTANADFASA--ILYAGLVEVPEKSSKRPSDVNVNPLY
VSHECKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDSLGIGMMLTFNAESLS
VEANEQLF-KNILDVWKDIPSSVAFECSQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSNYGV

-----------------------------------------------------LTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRY

PF00069 // ENSGT00920000148966_3_Domain_1 (92, 321)

SDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVNMTRNQSLKEEWIAYICREILQGLVHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSVNMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1582)

VQNIKNEGHVVESLKKHLTGIIKRRQKKEKGIPLIFEKEE
VIKEQYNM---RRFRGPSCTHELLRLPNSSRCRPLRVLHGEPSQPRWLPDQVEPQVQALQ
QLQGAARVFMPVQAQDNAPRLLQGQAHVPQRLQGA-ARVFMPLQAQVKAKASRPLQMQVK
APPRLWRAAKVLMPLQDQFKASRPLRVHA--QVA-KKHHTQTQPQVSEQPQDL---DQVP
EDIQGQGQVPEQQQKQDQAAEQEPEQNQGPEEQLEQ---NQVPVHPEVEEQAAEPVQA--
ETEAEEP-EVFRV------HAQVFLP--------------------------------LL
LQNHHVLLPL----HLDTQ--VLIPVEG--QTEQTPQAQVWALDPLLAVGSV--------
QDLIEGL-----------SRNLLRAPNSHNS--KPLGPLQMLMENLSSN----------M
FYSQPEKARK-KKSKVSSIRQALAKRLSPKRFWTKSSQRTEELELSDLEAHRQR-QQCRW
EEGL------------RQVTN-EKAEETSDNDEVFHSIQAQ--VQIEPLQPYVTNPKG--
---NEVQERSSS---MPYSQDC------AHRVK----FSL--------------RKQNR-
--------S-VRN-------------KKPEK-LGA-------KQR-ELLNNQIWLHSTES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVNVHVPDGFKIGKLSPPVY--LINEWVGCNAR
SEIFQNDWLTPAPITQ----PPEED--------------------GDYVELYDAGANTDG
NDDD----------------NSNDVYEDTYNDDNDNDDFNNQAVQANDSYNDHDDEKDE-
-----------------IVDD---EDNNHNDDPSLARPSYVRDGRGSSSKQHDRYGSD--
--------GREATL----------ISYRSQRTSRNQGESPASGVSAATGDHGRYGTNIGS
GRRGRRSNGGKKFNGTSEESETH---------GFSGGEKSS-------------AIDG--
-----------------PEL-E------------RS---AFQ--DL-EHQQEVPNGGSKA
SNASTSSTALS---------APDDEND-NKDISES-STKSDFSASHSF------------
----------------PSKSSRQAANVAFASG--ISYARLVEIPEKRPER-SDVNVNSLY
VSPACKKPLIHMYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

CCGFLW---GVNLLLGTQSDLYLMDRSGKADITKLIKRR
PFHQIQV-IEPLNLLITISGCKNRLQIYHLTWLRNKILNDDPESKRRQEEMLKTEEGCKV
IDKLTG-EHFSVL-QHEETIYIAIVLKSSIHLYVWAPKSFDEDTATK-VVTDQSADSKGD
YMSYEGYIRMQLIQRT-----GLSDQKNSLHLLKLKVF--PTLGHKPMTVDLAIDSEKRL
KIFFSSMDGYHIIDAESEAISDVTLPINPLEIMLPQNI-IILPDCLGIGMILTFNAEALS
MEANKQLF-KKILEMWKDIPSSVAYEYTQRTTGWGQKAIAMHSLQSWVLEDELKCRSIKK
LRFLCSRGDK-LFFTPTLHNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTALPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VQNIKNEGHVVESLKKHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLRAQDNAPRLLQGQAQAPQRLQGA-ARVFKPLQAQVKTKASRPLQMQVK
APPRLRRAAWMLMPLQAQVKTPRPLQL--QAQVP-KEQQAQAQPQASEEPQDL---DQVP
EEFQGQDQVPEQQQRQGQAPEQHQGQNQLPEQQLEQ---NQVPEQPEVQEQAVEPTQA--
ETEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QIEGSPQAHIWALEPPQAVGSV--------
QELIEGL-----------SRDLLRAPNSHNS--KPLGPLQTLMESLSSN----------M
FYSQPEQAGK-KKSKVSSLRQALAKRLSPKKFRAKLSQRPEEFEISDLEACRRR-CQRRW
EDIFNQHEE-----ELRQVAN-DKEDESSDNDEVFHSIQAE--VQIEPLQPYVPNPKG--
---NEVQERSTS---VPYNQDC------AHYVK----FSS--------------------
--SVP-QRS-VLE-------------QAQKP-IDI-------RQR-SSQNPQNCPAVSES
S-SEEESPVTWRRSQSSPPYSTIDQKLLVDVHVPDGFKVGKISPPVY--LTNEWVGSNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDTGA---D
TYGDD-DD-------------SNGAYEDTYDHDNGNDGLDNQVGQVNGIGEDHDDNDND-
-----------------EAIDDKDNNHDD--APCRPRPSYG-DGSY---KQDGRDGND--
--------GGEGTC----------NSYGSQRVSRSHGGSVASGGSAAIGDHEEHRANIGN
GRRVK-VNGGKGVSGTNEESGAF---------ELSEGENYSET----------AETDG--
-----------------QGL-E------------RL---TSQ--DF-EHQQEEPGGRSEA
SNAIASDAAPA---------APDDKND-SMDILEA-STQSGFSASHSS------------
----------------PSNSSGRAANADFASA--TLYTGLVEAPEKSPKPPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPDSKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTVGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKNIPSSVAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSIYDV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPQLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QTQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TGGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGRSAASEDNAATGDQEEHAANIGS
ERKGSGGDGDKAVIRTSEESGAL---------GPNGEENCS-------------ETGG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-STQSDFSANHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPHY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGSWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 320)

SLEKTIGLGTYGRIYLGLHEKTGSFVAIKVM
----NARKTPLPEIGKRVRVNKYRKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGA
FFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQ
VIHRDIKGQNVLLTQDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRR
SYDYRV-----------------TLCNLQPLEALFVILREAAPTVKSSGWSRKFQNFMEN
CMIKNFLFRPTSGNMLHHP

ENSGT00920000148966_3_Linker_1_2 (320, 1583)

FVHDIKNERRVVESLTKHLTGIIQKRE--RKGIPLAFEGEE
AVNEQYIT---RRFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDEEQPEDQELQ
QLQEAARMFMPLHSQDKTLKPLQKQAQLPQHLHVA-PQVLMPVQV--EATVATPLAKKIR
APPQLSKAAWGLTSPPSQDNKASSPEVQA---PIPREQQAQNDALETEQPEDL---DQVP
EEFQGQDRAAEE-QRQGQAAEQEQRQNGVPEQHPEE---NREPEQAEVQEEAVEPPQA--
EVEEKDP-EVIQV------HARVFLP--------------------------------LQ
SQNHHVFLPL----HLDTQ--LLIPVGE--QNEEAPRAQAWDLEASRAAGAV--------
QALVEGL-----------SRDLLRAPNAFTS--KPLGPLQILLESLCTN----------G
FYTEPEAVQK-KKSRVSSLKKAIVKRLTPKRFRAKALWRRQDFECSDVESSRRR-RQRRW
EEIFNQHEE-----QLREVENDRDDDDSSDNDEVFHSIQAE--VQIEP---YAPNRTG--
---NEVQERSAP---MPCNRNR------THRVK----FSP--------------------
--SVC-EQA-LLE-------------EAQQP-MDI-------RPRN-SLNPRNFQAESES
S-SEEDSPVTRRKSQSSPPYSTIDQRLLIDIHVPDGFKVGKISPPVY--LTNEWVGCNPL
SEVFWDDWVNPTPATR----RHEED--------------------GDYVELYDADANGDG
RA-------------------SNYAYEENYA--SGHDDMNHQA---NGYRGHGNRHYSD-
-----------------GSF--RNRGDSRGAAFNGPRASYCRGGILKNAGNDGRDL----
---------RRGAF----------RAYGDNEASNYHG--AASGASAAFGSQEGHEGHMGG
RR----GNRYREVNGSSGENGAC---------GFHR--------------------DG--
-----------------AGLDQ------------QH---VFP--DF-ENEQEQSDAGTET
SDSIALEITSF---------SLDGEQN-NDRAE----PTLGFPLRRSS------------
----------------SRGS---ASDTD-------------------------------I
MSDSYNKPIIHAYEREFSHEIF

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTKSHLYLMDRSGKAEIIKLVKRR
PFRQIQV-VEQLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKKRQKAMLKREKACKS
LDKLIGCEHFSIL-HHEETTYIAIALKSSIHLYAWAPKSFNESTAIK-------------
------------------------------------VF--PTHDLKPVTVDLAVGSEKTL
KIFFSSANGYHIIDAESEVMSDVTLPSN--------NV-ILLPDSLGVGVMLSFNDETAP
EEANEQLL-KKILDVWKDIPSSAAFECTQRITGWDQKAVEVRSLQATILENELKRRSIKK
LRFLCSRGDK-LFFASLLNNEHSLVYYVSIAKLEALQRRYAV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGKIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGVPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKLQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQHRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEAFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAVSES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVAQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERKGSGGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RP---VSQ--DF-EYLQEEPGGGNEA
SNAIDSGAALS---------APDDESD-NKDISES-STQSEFSVNHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPGSKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

-----------------------------------------------------------M
SV----------------------------

PF07714 // ENSGT00920000148966_3_Domain_1 (91, 316)

TEDEEEEIKMEINMLKKYSHHRNIATYYGA
FIKKNLSGHDDQLWLVMEYCGAGSVTDLVKKTKGNSFKEDWISYICREVLRGLSHLHMHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTAGRRNTFIGTPYWMAPEVIACDENPDS
TYDYRSDLWSLGITAMEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFIEN
CLVKNYIHRPSTEAL

ENSGT00920000148966_3_Linker_1_2 (316, 1583)

LRHSFIRDLPNERQVRIMLKDHLDRTKKKKGDKDETE-YEYSGEE
EEEE-----------------------------EINEDQGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKKNPQ--------
-----------------------NL----QKEEQNQQQEQ--------------------
-Q-DLQQEDQNLQHKKQAPQQQPQQPPKMPAHHQVHHPAQQSLQLPVYHQA-KQPAQQAG
HRQMKQPPHHLSPYH----QAQQPQQV---------------------AQHQVKQHSEQP
ILYQTQLQPKQQQQLKDQDQYK----------ERGKLALGDMVQLSQQGKYV--------
--------------DKAMQPFIHTSSPEVKRMPKEFS------TSLPGK----AEER--S
QDHPPPQSAKPP-AAAGT------------------SGQAKSLEL-----KRE----RRA
GSLVTVAETLYIAPALQEVLAS---EDIQPNPAEFNPIKSLQRSGKPKLQHPSPTDCWTL
IQSKVSRGQGSSNSNTPTPQTAL------------------------R--DLLTKFQEGR
LTENPKTKKKMRGAR-GLTNMGNVA-----------------IRPKTSGKDDLF--RSK-
CPVEDQPPKVPPLITPSPPSVLETLN-----------------------LSQAWLKCTL-
--------SRPAPLPAQKFPLPLRSGSLST----LAGKGDGSWDLPSSESLFSGNLQSRE
DNNSQPPSSGGWAQKPK---TGS-------N-FTSNRQWAMECRVTNRATTG-ESQEPSL
N--M----TPTTQG---QSHIA---------NVTSL-HI---------------------
------YTH---HILHLLLLFPAQLGGSF-----ELGATPRDLGENELF-----------
------PAEDKGATSKPEDSNHPTEVVKNR------------------------------
------------------------------------------------------------
-------------------KCPSQNRASSHPILD--LSSYPFSSS---------------
NYFWVLLAVIDDNGSGPSHPFGI-GFGSD----------SQQFFQRNRRKTSVVNVNPIN
ARLQNDSPEIRKYKKKFSSEVL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CAALW---GVNLLVGTESGLWLLDRSGQGRVYSLISRR
RFQQIDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVGKKQG--------WIS
VGDLEGCVHYKIERSYINVGFLFSASLNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--HSLYQKPLAVDLTVENGQRL
KVIYGSVAGFHAIDVDSGTVYDLYLPTHIHGTIQPHTI-IILPNTSGTELLLTYEDEGVY
VDIYGHFT-KEAILQWGEMPGCVAYLQSNQIMGWGERAIELRSVEAGNLEGVFMHKKSQK
LKFLCERNDK-VFFASVQSG-SSQIYFMTLRRNTFFNW----

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGKIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKLQTQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQHRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEAFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAVSES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERKGSGGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RP---VSQ--DF-EYLQEEPGGGNEA
SNAIDSGAALS---------APDDESD-NKDISES-STQSDFSVNHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPGSKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSVPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SRDLLRAPNSINS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEELELSDLEARRRR-RQHRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKSYISNPKK--
---VEVQERSPS---VPNNQDH------AHHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDASA---D
TDGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVYKDHDDDNNK-
-----------------SVDD---VNNNYYEAPSCPRASYGRDGRC---KQDSYGGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAAIGDQEEHAANTGS
ERRGSRGDGGKVVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------SGL-K------------RP---ASQ--DL-EYLQEEPGGGNEA
SNAIDSGAAPS---------APDDESD-NKDISES-STQSDFSASHSF------------
----------------PSKGSGTSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQKEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDKEVTDLGHLPVSTPR-----------PPPSLCGLHEKTGSFTAVKVM
----NARKTPLPEIGKRVRVNKYQKSVGWRY

PF00069 // ENSGT00920000148966_3_Domain_1 (92, 321)

SDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREVLQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSGNMLHHPFVQNIKNEQHVVESLTKHLTGIIKKRQKTGKDNKALYNSDK
RGSYIYLLFLVSFIFV--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 321)

FSLDKTIGLGTYGRIYLGLHEKTGALTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGR-NSFIGTPYWMAPEVIDCDEDPRR
SYDYRXXXXXXXXXXXXXXXXXXXLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VRNIKNEGHVVESLKKHLTGIIKKRQKK------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----VQERSIS---MPYNQDR------VHRVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDM-------RQR-SSQNPQNCPAASES
S--SEESPVT-RRSQSSPPYSTDK---VLMNHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDAGADTDG
DDD-----------------DSNDAYEDTYDHDNGCDELDNQVDQANDAGEDQDDDDND-
-----------------EVVD--DKGNSRDDAPSWPRPSCGRGGSYKQDGKDGSD-----
--------GGEGTF----------SSNGSQRASRSHGGSTAIRGSEAIGDHEGHRANTGS
GRRGKESNGNEGISGTNEESEAL---------ELNGEENCS-------------EIHD--
-----------------PVL-E------------RP---ASQ--EF-EHKPEELGGRSEA
SNAVASGAAPA---------APGDEND-TVDISEV-STESGFSASHSS------------
----------------PSKGSEGAANADFAST--ILYAGLVEVPEKSSKQPSEVNVNPLY
VSPECKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAYECSQRATGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSTYGV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKNYLHRPSTETLLKHSFIRDMQNERHVRIMLKDHLDRTRKKRGEKEETE-YDYTGSE
EEDD-----------------------------ELDEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PH----RQQPPLKDQEKYKKQLLAERQKRI---EQQK
EQ---RKRLEDHQKREQELRKQQECEQQWPEIKAVQRRDEKYEDDPRIVD--EEMCKGDG
QRKLE--------------RKQ---------------------KKAEDVQP-SKKLHRTL
PKDQTQLL----SLQHDHRQKK----------K----------ELPKSSSSA--------
-------------------------A-----------------PPLPSC----TSKE--A
E------DRKKK--NEGV------------------------------------------
---------------------------------------------KAPLHRVAVHDHEAT
PHARLGSGSSSSP-CTPALQRAVLAQSENLRTSRDICHS----SS-LS--DM--------
-----------------------------------------VGTPMSLGQDDVFWS----
---EEQPPKVPERTTSKFYSRDH-LG---------------------------HQKGP--
---------------------S-----------------------SNVHQ----------
------ASPGGRALKLS---SNS-------SSSPGSRQGAIGAHLSKRSTSG-SSKAENP
P---SQNRRPQCQK---SEN----------------------------------------
------------APHPAQFSSPAFFAKGKDGANSFSTATEYSSSSDELV-----------
-------------SSDDDEMIHTRQLLSNGMADFSRTRV-----PDGIELK---------
-------PQSIVIEQKNHIAGKQSCSTKEGLWSIQNQNYL-----LPDLLQQSQ-ISDSS
ANQQKVTQNSQGAQNKS---TSSAESTPSKGSS---SSTTSFTPFIDP------------
--RLLQI-------SPPSSPVGP-TCNS------PSSPKLEPVRRQNARKGSVVNVNPTN
IRPQSDSPEIRKYKKKFNSEIL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1781)

CAALW---GVNLLVGTENGLWLLDRSGQGRVYSLITRR
RFQQMDV-LEGLNVLITVSGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WMS
VGDLEGCVHYKVV-KYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK-------------
------------------------------------VR--QTSSWFSCI-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGSWRDKEVTDLGQLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKAIGLGTYGRIFLGIHEKTGSLVAVKVM
----SARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGA
FFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQ
VIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRC
SYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMEN
CMIKNFLFRPTSGNMLLHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VHDIKNERRVVESLTKHLTGIIQKRE--KKGTPVAFEGEE
AVKEQYIT---RRFRWPSCTPELLRVPTSSRCRPLRILHGEPPQPRWLPNQEDPQDQELQ
QLQKAAGVFMPLHSQDNTPKLFPKQVEVAPYLRGA-AQVVMPVLV------------QVE
APPQVSKAAQNLKSLPTQDNKATSPEVQA---PVAEGQQAQHEALETEQPKDL---DQVP
EEFQEQDRAPEQ-PRQGQAAEQQQIHNPVPEQPPEE---NRAPEQAEVQEEAVEPPQA--
EIEEKEP-EVVQV------HAQVLLP--------------------------------LL
SQNRHVLLPL----HLDRQ--LLIPVGE--RNEEAPRAQAWDLEASRAIGAV--------
QALIEGL-----------SRDLLRAPNAFVT--KPLGPLQIFLENLSTD----------G
FYTEPEPTQK-KKSKVASLRKAIAKRLRPKRFRAKALWRLEDFEFSDVETSRRR-RHRRW
EDIFNQHEE-----QLRRVEN-DREDDSSDNDEVFHSIQAE--VQIEP---RAAHAAG--
---NEVQERSAP---IPCNRNR------THRVK----FSP--------------SVGEEE
P-SLE-EAQ-PQQ-------------PQQQP-MNI-------RPRN-CLNPQNSQAQSDS
S-SEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFWDDWIMPTRPAR----PPEED--------------------GDYVELYDADANAHG
D-E-----------------VANGAYEDPRDGANGHDDMNNQLDQAN-----GAAGYNG-
-----------------R-----DVDGNHGAAFNGPRANYPRAGILKNGNNDGRNL----
---------NRGAF----------GAYGDDAARAFHG--AAAEAGAAFGNH---GANRGN
GRG----NRNREANGRNEENGAF-------------------------------------
------------------GR-D------------QH---VFP--DF-EHEESDRGT--ET
SDSIALDITS-----------LDGEQ--N-SGRPVSS-TMGFPIGRSS------------
----------------PRG-------SDFGS-----------------------------
-DISYNSPILHVYEKEFSSEVY

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTQSHLYLMDRSGKAEIVKLIKRR
PFRQIQV-VEQLNLLITISGNKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKA
IDKLIGCEHFSVL-QHEETTYIAVAVKSSIHLFAWAPKSFDENTAIK-------------
------------------------------------VF--PTRDLKPLTVDLAVGSEKTL
KIFFSSANGYHIIDAESEVMSDVTLPNN--------NV-VILPDCLGLGVMLSLNADAAS
EEANEQLL-KKILDVWKDIPSSVAFECTKRITGWEQKAIEVRSLQSTILENELKRRSIKK
LRFLCARGDK-MFFASTLSNEHSRVYLMSIGKLEELHRSYAV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLQHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTV---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QSQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKPYISNPKK--
---IEVQERSPS---VPNNQDH------AHHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDASADT--
-DGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------FVDD---VNNNYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHTANRSHGGSAASEDNAAIGDQEEHAANIGS
ERRGSEGDGGKGVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNEA
SNAIDSGAAPS---------APDHESD-NKDISES-STQSDFSANHSS------------
----------------PSKGSGMSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VQEIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQSPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-D-------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSYPRASYGRDGSC---KQDGYDGSC--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAATGDQEEHAANIGS
ERKGSGGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-SIQSDFSANHSS------------
----------------PSKGFGRSADAKFASA--ILYAGFVEVPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDKDKEEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAATGDQEEHAANIGS
ERKGSGGDGDKAVIRTSEESGAL---------GPNGEENCS-------------ETGG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-STQSDFSANHSS------------
----------------PSKGFGKSADANFASA--ILYAGFVEVPEESPKQPSEINVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVMCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

-----------------------------------------------------------M
----NARKTPLPEIGRRVRVNKYQKSVGWRY

PF00069 // ENSGT00920000148966_3_Domain_1 (92, 262)

SDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWIVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRANGRRNSFIGTPYWMAPEVINCDEDPRH
SYDYRSDVWSVGITAIEMAEGVPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPFVQDIKNEQHVIESLTKHLTGIIKKRQKKGRI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------Y

PF00069 // ENSGT00920000148966_3_Domain_1 (41, 321)

YAIFQGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPAGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VRNIKHEGHVVESLKKHLTGIIKKRQKKEKGIPLIFEREE
DIKEQYTT---RKFRGRCCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HPQGAAKMFKPLQAQNNAPRSLQGQARPSQRLQGA-AQVFMPLQA------------QIK
APPRLRRAAWMLMPLQAQVKAPRSLRL--HAQVP-RDQKDQAQPQESENPQDL---DRVP
EEFQGQNQVPEQQQGQVPAPGQQQGQNQLPEQQLEQ---NQVPEQPEVQEQAAEPTQA--
ETEAEEL-ESLHV------QAQVFLP--------------------------------LL
SQNHHVLFPL----HLDTQ--VLIPVEG--QTKESPQAQAWALEPPQDVGSV--------
QALIEGL-----------SRNLLRAPNSHNS--KPLGPLQTLMENLSSN----------I
FYSQPEQAQKKKKSKVSSLRQALAKRLSPKKFRAKLSRRPEEFELLDLQAYRRR-RQRRW
EDIFNQHEE-----ELRQVASKDKEDESSDNDEVFHSIQAE--AQIEPLQPYVPNPKG--
---NEVQERCTS---VPYNRDH------AHHIM----FSS--------------STGSKN
LS-KY-SLN-LNK-------------QVQKP-IDT-------RQR-SLQNPQNCPATSES
S--KEESPVTRRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPFIQ----RVDDK--------------------GNNHDDAP-------
----------SW------------------PSEFIGVTLVNKIIQVSGAK----------
-------------------FHNTSSAQSTVLCIHHPKSSYGRGASW---KQNGRDDDN--
--------GGEGTC----------SSYGSQRTSRSHLRYAASGDNTAMGDHEEDKANIGS
GRRGMEGN---------------------------------------------GETDD--
-----------------PGL-E------------RP---TSQ--DN-EHQQEESVGRSGT
SNAIA-----S---------TPNDEND-SIDISEA-STESGFSASHSS------------
----------------PFNISGSATNTEFAN-----------------------------
-SISCKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLWE-TGVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSANGYHIIDAESEVMSDVALPNN--------NI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAYECTQRTTGWGQKAIEVRSLQSRLLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

---------------------LQDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTSMPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLNPP--------------AGSVTDIVRMTRNQSLKEDWIAYICREILQGLAHLHSHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTHGRRNSFIGTPYWMAPEVINCDEDPRS
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRDSAPTVKSSGWSRKFHNFMEK
CMVKNFLFRPTSGSMLHHPFVRDIKNERHIVESLTKHLTGIIKKRQKKDKYVCNQPFTDS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

--------------------------------------------Q

PF00069 // ENSGT00920000148966_3_Domain_1 (46, 321)

GRHVKTGQLAAIKVM
NV----------------------------TENEEEEIKLEINMLKKYSHHRNIATYYGA
FVKKSPAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKHYLHRPSTETLLKHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

IRDMQNERQVRIMLKDHLDRTRKKKGEKEETD-YDYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PH----RQQQQLKDQEKYKKQLLAERQKRI---EQQK
EQ---RRRLEDHQRREQELRRQQESEQRWPEVKVSQRKEERGKEDKRAVED--ECFIVDG
QRKLE--------------KKQ----------------------KMEDVQH-NRKMHRTL
PKDQTQLL----SLQHDHKQKK----------K----------EPSSSSNAG--------
-------------------------L-----------------HPPSSS----TSKE--A
E------DRAKK--SDSS------------------------------------------
---------------------------------------------QPS-AQRPAPGHEAA
PQPRLGSGSSSSP-CTPAPQRALLLQCEDFRASKDVYHS----SS-LS--DM--------
-----------------------V------T---------APLS---PGQDDVFWS--T-
SHSKEQPPKVPERTTSKFYSRDQ-PG---------------------------HQRCL--
---------------------S-----------------------SNTHQ----------
------ASPGGHALKLS---SSS--------STPGTKQWEMGSHQSSWSTSG-NPGLAKA
ENVLSQNHVLLHQK---PEKVS--------------------------------------
--------------HPGQIASPGSFPKVKDSANSLLKAADYSSSSDEVS-----------
------SS----SSSDEDDTNHTRQLLSGRIADFSRTRV-----ADGIELK---------
-------PQSTVAEQKDQILGKQIPSTQEGLWSINNQNYL-----LPDLLQQSQ-ITDSS
VNPPQVPLTCQEPQNKPLTKSPCAESPPAKSST---SSTTSFTSFIDP------------
--RLLPV-------TPPTSPVGP-SCSS------PSSAKPEPVRRENARKGSVVNVNPTN
IRPQSDSPEIRKYKKKFNSEVL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CAALW---GVNLLVGTENGLWLLDRSGQGRVYTLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHHKPLSVDLTVENGQRL
KVIYGSVVGFHAIDVDSGSVYDLYLPTHIQGTIRPHAI-IILPNTSGMELLLTYEDEGIY
IDIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGEKAIELRSVETGNLEGVFMHKKAQK
LKFLCERNDK-VFFASVQSGGSSQIYFMTLGQNVLFNW----

----MAGPGGWRDKEIADLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFIILRESAPTVKSGGWSRKFHNFMEK
CMIKNFLFRPTSANMLVHPFVQDIKNEQHVVESLTKHLTGIIKKRQKKGRT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------------------

PF00069 // ENSGT00920000148966_3_Domain_1 (44, 321)

WQGRHVKTGQLAAVKVM
SV----------------------------TEDEEEEIKMEINMLKKYSHHRNIATYYGA
FIKKNLSGHDDQLWLVMEYCGAGSVTDLVKKTKGNSFKEDWISYICREVLRGLSHLHMHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTAGRRNTFIGTPYWMAPEVIACDENPDS
TYDYRSDLWSLGITAMEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFIEN
CLVKNYIHRPSTEALLRHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

IRDLPNERQVRIMLKDHLDRTKKKKSDKDETE-YEYSGSE
GEEE-----------------------------EEE-EEEEEDSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKKSPL--------
-----------------------S------KEQQLKREQQQQQQLMWQRLEKEQRELQQK
QQ-DLQQKQQNLQQKQQDLRQKQQ---------DLQQEQQALQKEQQALQK-EQQALQQG
QKVLQQEKQTLQQSQQDLKQEQQALELDQKDLQLDQEALQQDQKALQQDQKALEQDQKAL
QLDQQALQPDQQALQPDQK--A----------L----------QPDQQEKQA--------
--------------P-----ELLPKPQKPPLLPKL--------Q-LPQQ----PEHH--Q
EQQPPKQEQQPP--KQGL------------------------------------------
---------------------------------------------QPP----KYSSHHI-
---SISSAADPSP-VEAAISTAPT-----------------------TNPAAFTASGPGE
TASTA-DTTATKATTAA------VQ----RP---------GLDPKSSVPAPPASALTSI-
SPAEDQPPKVPERTTSRFRSKDI-IN---------------------------QARRH--
---------------------PIQTQNVRN-------APNLLWSAYCNHSLYMG------
--TPFKPSSGGWAQKPK---SGS-------KSQ------------------------N--
PQDLSRGEPRFTEK---PQVVL---------GSVGCLDFLGKGERQKQSVGSSRHELPLT
RVLEPLYKNGERPPPPVQILFLRNFTAGK-DIRLFLNASEFSSSSDEIF-----------
------S-------SDEEEYGYPSPRHESRS------------IPTAVTVPNQFPVSTSL
TYF-----------------------IQSCLFAPPRNPYEFRTDYDPRKLLMVV-LSDRT
SLPNDVPYPALHPQPSPP--PPSAKKGGWHPLS---NGGLNFSRRRAPKGQEMKAKSRGV
ESKLAQEASKGERGQDSLRLFGD-NCGL------------LDVLNRKSRKTSVVNVNPIN
ARPHSDSPEIRKYKKKFSSEVL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CAALW---GVNLLVGTEKGLWLLDRSGQGRVYSLINRR
RFQQIDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEMGKRQG--------WIS
VGDLEGCVHYKVV-KYERIKFLVVALRNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--PSLYQKPLAVDLTVENGQRL
KVIYGSVAGFHAIDVDSGMVYDLYLPTHIPGTIQPHTI-IILPNTSGTELLLTYEDEGVY
VDIYGHFT-KESILQWGETPACVAYLQSNQVMGWGEKAIELRSVEAGNLEGVFMHKKSQK
LKFLCERNDK-VFFASVQSG-SSQIYFMTLGQNTLFNW----

----MAGPGSWRDKEITDLGHLPXXXXXXXXXXXXXXXXXXXXX

PF00069 // ENSGT00920000148966_3_Domain_1 (45, 321)

XGLHEKTGAFTAVKVM
----NARKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSMGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VQNIKNEGHVVESLKKHLTGIIKKRN---KGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
DLQGEARVFMPLQAQDNVPRSLQGQTQASQRLQGA-AHVFMPLQVQVKAKTSKPLQMPIK
APPRLRRAAWMLMPLQAQVKAPRPLQLQA---KILKEQQAQAQPQASEEPQDL---DQIP
EEFQGQDQVPEQQQRQGQASEQQQWQNQVPEEQLEQ---NQIPEQPDRQEEAAEPTQA--
EIEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEE--QTKESPQAQAWAPEPPQAVDSV--------
QALIEGL-----------SRDLLRAPNSHNS--KPLGPLQTLMENLSSN----------M
FYSQPEQAQK-KKSKVCSLRQALAKRLSPKRFRAKLSRRTEEFELSDLEACRRR-RQRRW
EDIFNQHEE-----ELRQVAN-DKEDESSDNDEVCQCIQAE--VQIEPLQLYIPNHKG--
---NEXXXXXXX---XXXXXXX------XX--------------------------XXXX
XXXVP-QRS-LLE-------------QAQKP-IET-------RQR-SSQNLQNFLATSES
S--EEESPVIARRSQSSPPYSTIDQNLLLDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIH----PPEEN--------------------DDYVKVYDAGAVTDG
DDD-----------------DSNDAYEDTYYHDNGNDVLDIQVVQANDVGKDHDDDGND-
-----------------EAVD--DKDSNHDDASSWPRPHYCKGGSWKQNVRCGSD-----
--------EGEETC----------SSNGSQRARRSHGGYAASGGNTAIGDYEGHKANIES
RRRG---KAGRRVSGTNEESEAL---------ELNEGENCS-------------ERDG--
-----------------PGL-E------------IP---ASQ--DF-EHQHEEPVGRSEA
SNAP------A---------AHNDGND-SINISEA-STESGFSASHTS------------
----------------PSNVSGRATNADFASA--ILYAGLVEVTEKSPKKSSEVNVNPLY
VSPVCKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

ASEICCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRMYHLTWLKNKILNDDPESKRRQEKMLKTEEACKA
IDKLTGCEHFSVX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIILQNI-IILPDSLGIGMMLTFDTEALS
TEANEQLF-KKILEVWKYIPSSVAYECTQRITGWGQKAIEVRSLQSRHLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQINYGV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLQHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QSQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQR-HQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKPYISNPKK--
---IEVRERSPS---VPNNQDH------AHHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDASA---D
TDGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------FVDD---VNNNYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYRSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERRGSEGDGGKGVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNEA
SNAIDSGAAPS---------APDHESD-NKDISES-STQSDFSANHSS------------
----------------PSKGSGMSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHLIDAESEVMSDVTLPKN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYDV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------RQPLSNGVMGFSRARA-----PDGIELK---------
-------PQRAGMERKDYAAGRPNCSTREGFWSMSNQNYL-----LPDLLQQSQ-ISDCS
DFQPKAVENSFILSVLPI-QASSTDNTSPKNST---SSTTSFTSFIDP------------
--RLLQI-------SPPSSPTGP-NCGS------PPNVKPESSSRQNARKGSVVNVNPTN
IRPQSDSPEIRKYKKKFNSEIL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CSALW---GVNLLVGTENGLWLLDRSGQGRVYSLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIAVRNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHQKPLLVDLTVENGQRL
KVIYGSSVGFHAIDVDSGSVYDLYLPTHIQGNIHPHAI-IILPNTSGMELLLTYEDEGVY
VNIYGHFS-KENVLQWGEMPASVAYLQCNQVMGWGEKAIELRAVETGTLEGVFMHKKAQK
LKFLCERNDK-VFFASVHSGGSSQIYFMTLGQNILFNW----

----MAGPGSWRDKEVTDLGQLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKAIGLGTYGRIFLGIHEKTGSLVAVKVM
----SARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGA
FFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHQ
VIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRC
SYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMEN
CMIKNFLFRPTSGNMLLHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VHDIKNERRVVESLTKHLTGIIQKRE--KKGIPVAFEGEE
AAKEQYIT---RRFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQPRWLPDQEDPQDQELQ
QLQKAAGVFMPLHSQDNTSKLFPKQVEVAPYLRGA-AQVVMPVLV------------QVE
APPQVSKAAQMLKSLPTQDNKATSPEVQA---PVAEGQQAQHEALETEQPKDL---DQVP
EEFQGQDRAPEQ-PRQGQAAEQQQIHNPVPEQPPEE---DREPEQAEVQEEAVEPPQA--
EIEDKEP-EVVQV------HAQVLLP--------------------------------LL
SQNRHVLLPL----HLDRQ--LLIPVGE--QNEEVPRAQAWDLEASRAVGAV--------
QALIEGL-----------SRDLLRAPNAFVT--KPLGPLQIFLENLSTD----------G
FYTEPEPTQK-KKSKVASLRKAIAKRLRPKRFRAKALWRLEDFEFSDVETSRRR-RHRRW
EDIFNQHEE-----QLRRVEN-DREDDSSDNDEVFHSIQAE--VQIEP---HAANPAG--
---NEVHERSAP---MPCNRNR------THRVK----FSP--------------SVGEEE
P-SLE-EAQ-PQQ-------------QQQQP-MNI-------RPRN-CLNPQNFQAQSDS
S-SEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFWDDWIMPTRPAR----PPEED--------------------GDYVELYDADANANG
DEE-----------------VANGAYEDPRDGANGHDDMNNQLDQANGYEGHGAAGYNG-
-----------------G-----DVGGNHGAAFNGPRANYPRAGILKNGHNDGRAL----
---------NRGAF----------GVFGDNAARAFHG--AAGEAGAAFGNH---GANRGN
GRG----NRNREANGRNEENGAF-------------------------------------
------------------GR-D------------QH---VFP--EF-EHEESDRGT--ET
SDSIALEITS-----------FDGEQ--N-SGRPVSSTTMGFPIGRSS------------
----------------PRG-------SDFGS-----------------------------
-DISYNSPILHVYEKDFSSEVY

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTQSHLYLMDRSGKAEIVKLIKRR
PFRQIQV-VEQLNLLITISGKKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKA
IDKLIGCEHFSVL-QHEETTYIAVAVKSSIHLFAWAPKSFDENTAIK-------------
------------------------------------VF--PTRDLKPLTVDLAVGSEKTL
KIFFSSANGYHIIDAESEVMSEVTLPNN--------NV-VILPDCLGLGVMLSLNAEAAS
EEANEQLL-KKILDVWKDIPSSVAFECTKRITGWDQKAIEVRSLQSTILENELKRRSIKK
LRFLCARGDK-MFFASTLSNDHSRVYLMSLGKLEELHRSYAV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKFSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMEFCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAYR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---KRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFVPLQPLDSAPRPLMGQAQAPLRLQGA-ARVFMPLRAQVKPKATRPLQMQIK
APPRLQRAARVLMPLQAQGRTPRLLQVQ--AQVPKK-QQAQTQ---ASEPQDL---DQVP
EEFQRHDQVPEQ-QRQGQAPEQLQGHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
EAEAEEP-ESLRV------HAQLFMP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTEGLPQAQAWTLETPQAVDSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSLN----------R
FYSQPEQARK-KKSKVSSLRQALAKKLSPKRFRAKSSRRPEELQLSDLEARRQR-RQHRW
EDVFNQHEE-----ELRQADK-DNEDESSDNDEVFHSIQAE--VQIEPLQPCISNPKI--
---IEVQESSPS---APNNQDR------ANHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPISQ----PHEED--------------------GDYVELYDVGAGTDG
DDEH----------------EPNDAYEYTYDHANGNDDSDNQVDQANDVYEDHDDDNNK-
-----------------SVDD---VNDNYHKAPRCPRASYGRDGSC---KPGGYDGSN--
--------GKEEAY----------RGYGRHGVNSSHEGSAASEDNAATGDQEDHAANISS
ERRDSGGDGGKGVIRTSEDSGAL---------GLNEKENCS-------------ETDG--
-----------------PGL-K------------RP---AFQ--DF-EYLQEEPGGGNEA
SNAIDSGAAPS---------APDDEND-NKDISES-STQSDFSASHSS------------
----------------PSKGSGRSTHADFASA--ILYAGFVEVPEESPKQSSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMMKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCTDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSNYSV

----MAGTGAWRDKEIIDLGHLPXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXX
XXXXXXXXTPLPEIGRRVRVNKYQKSVGWR

PF07714 // ENSGT00920000148966_3_Domain_0 (91, 169)

YSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXSDVWSVGITAIEMAEGAPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXGPSCTHELLRLPTSSRCRPLRVLHGESSQPRWLPDQVEPQVQALQ
QLQGAARVFMPVQSQDNASRLLPGQAQAPQRLQGA-ARVFMPLQAQVKAKESRPLQMQVK
APPRLRRAAQVLKPLQAQVKAYRPLQVQV---KVTIKQHAQTQAQVSEQPQDL---DQVP
EEFQGQGQISEQQQRQEQAPEQQQEQNQGPEEQLEQ----QVPEQPEVQEQAAEPVQA--
EPETEEP-EVLQV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPIEG--QTEGTPQAQAWALNPLLAVNSV--------
QELIEGL-----------SRNLLRAPNSHNS--KPLGPLQALMENLSSN----------M
FYSQPEQAHK-KKSKVSSLRQALAKRLSPKKFQTKSSQSPEEFELSDLEARRQR-RPHKW
EDVFNQREE------LRQVTKXXXXXXXXXXXXXX-XXXXX--XXXXXXXXXXXXXXX--
---XXVQERSNS---MPYSQDC------AHHAK----FPL--------------------
--SVP-QRS-PLE-------------QAQKP-IDI-------RQR-SSQNPQSCPAAQXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXX---XXXXXXXXXX
XX-X---XXXXXXXXX----XXXXX--------------------XXXXXXXXXXXXXXX
XXXXX---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----
--------XXXXXX----------X-XXXXXXXXXXXX-XXXXXXXXXXX---XXXXXXX
-XXX-XXXXXXXXXXXXXXXXXX---------XXXXXXXXX---------X-XXXXXX--
-X---------------XXX-X------------XXXXXXXXXXXXXXXXXXVPNGGSEA
SNASASSTAPP---------APDDEND-SKDVSES-STKSDFSASHSF------------
----------------PSKDSGRAGNADFANA--ISYAGLVEVPEKLPKQPSDVNVNPPY
VSPACKKPLIHMYDKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLW---GVKLLVGTRANLFLMDRSEKD--TKLIKRR
LF-QIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMPTIEKACKA
IDKLTGCEHFSVX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXPLEIIIPQNI-IILPNCLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAYACTQRTTGWGQKAIEVRSLQTSILESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEEFQSNCCV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMEFCAAGSVTDVVRMTRNQRLKEDWIAYICREILQGLAHLHAYR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILQESAPTVKSSGWSRKFHNFMEK
CMVKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKEIPLIFEKEE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARLFMPLQALDSAPSPLMGQAQAPLRLQGA-ARVFRPLQAQMKSKASRPLQMQIR
APPRLQRAARVLMPLQVQGRTPRLLQVQ--AQVPKKQ-QTQT---QASEPQDL---DQVP
EEFQGHDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
EAEAEEP-ESLRV------HAQLFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLETPQAIDSV--------
QALIEGL-----------SRDLLRAPNSNSS--KPLGPLQTLMENLSLN----------R
FYSQPEQARK-KKSKVSSLRQALAKKLSPKRFRAKSSRKPEELELSDLEARRQR-RQHRW
EDVFNQHEE-----ELRQVDK-DNEDESSDNDEVFHSIQAE--VQIEPLQPCISNPKI--
---IEVQERSPS---VPNNQDH------ANHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNHQNWPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPISQ----PHEED--------------------GDYVELYDVSADTDG
DEEH----------------ESNDVYDDTYDHANGNDDSDNQIDQANDVYEDHDDDNNK-
-----------------SVDD---VNDNYHEASRCLRASYGRDGSC---KPDDYDGSN--
--------GKEEAY----------RGYGSHRVNSSHEGSAASEDNAATGDQEEHAANISS
ERRDCGGDGSKRVIRTSEESGAL---------GLNGKENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPDGGIEA
SNAIDSGAAPS---------APDDEND-NKDISES-STQSDFSASHSS------------
----------------PSKGSARSTDADFASA--ILYAGFVEVPEELPKQPPEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEALNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTGEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCTDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KVFFSSADGYHIIDAESEVLSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSSQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYSV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLQHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QSQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQSRE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQR-HQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKPYISNPKK--
---IEVRERSPS---VPNNQDH------AHHVK----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELHDASA---D
TDGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------F-VDDVN--NNYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYRSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERRGSEGDGGKGVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNEA
SNAIDSGAAPS---------APDHESD-NKDISES-STQSDFSANHSS------------
----------------PSKGSGMSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMEFCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAYR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMVKNFLFRPTSANMLQHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKKERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQIQALQ
QLQGAARVFMPLQALDSAPRPLMGQAQAPLRLQGA-ARVFMPPRARVKSKASRPLQMQIK
APPRLQRAARVLMPLQAQGRTPRLLQV--QAQVP-KKQATQTQ---ASEPQDL---DQVP
EEFQGHDQVPEQ-QRQGQAPEQQQRHNQVPEQELDQ---NQAPEQPEVQEQAAEPAQA--
EAEAEEP-ESLRV------HAQLFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEE--QTEGSPQAQAWTLETPQAIDSI--------
QALIEGL-----------SRDLLRAPNSDNS--KPLGPLQILMENLSLN----------R
FYSQPEQARK-KKSKVSSLRQALAKKLSPKRFRAKSSRRPEELELSDLEARRQR-RQHRW
EDVFNQHEE-----ELRQADK-DNEDESSDNDEAFHSIQAE--VQIEPLQPCVSNPKV--
---IEVQESSSS---APNNQDH------ANHVT----FSS--------------------
--SVP-QPS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPISQ----PHEED--------------------GDYVELYDVGADTDG
DEED----------------ESNDAYEDTYDLANGIDELDNQVDQANDVYEDHDDDNNK-
-----------------AVDD---VNDNYQAASRCPRASYGRDGSY---KPGGYDGRH--
------------------------------SVNSSHEGSAASEDNAAAGDQEEHAANISS
ERRDSAGDGVKGVIRTSEESGAL---------GLNGKEKCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNEA
SNAL------S---------APDDEND-NKDISGS-STQSDFSASHSS------------
----------------PSKGSGRSTDADFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACTKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCTDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSNYSV

---------------------LQDPAGI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 321)

FELVQVVGNGTYGQVYKGRHVKTGQLAAIKVM
NV----------------------------TENEEEEIKLEINMLKKYSHHRNIATYYGA
FVKKSPAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKHYLHRPSTETLLKHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

IRDMQNERQVRIMLKDHLDRTRKKKGEKEETD-YDYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PH----RQQQQLKDQEKYKKQLLAERQKRI---EQQK
EQ---RRRLEDHQRREQELRRQQECEQRWPEVQVSQRKEERGKEDKRAVED--EYFIVDG
QRKLE--------------KKQ----------------------KMEDVQH-NRKMHRTL
PKDQTQLL----SLQHDHKQKK---------------------ELSKSPNAG--------
-------------------------V-----------------HPPSSS----TSKE--A
E------DRAKK--SDSI------------------------------------------
---------------------------------------------QPS-LWPVALGHEAT
PPARMGSGSSSSP-CTPAPQRALLLQCENFRASKDVYHS----SS-LS--DM--------
-----------------------V------T---------APLS---PGQDDVFWS--M-
SDSKEQPPKVPERTTSKFYSRDQ-PG---------------------------HQRCL--
---------------------S-----------------------SASHQ----------
------SSPGGHALKLN---SSS--------SIPGTKQWEVGSHQSSWSTSG-NPGLTKA
ENVLSQNHVQLHQK---PEKVS--------------------------------------
--------------HPGQIASPGSFAKVKDSANSLLKAIEYSSSSDEGS-----------
------SS----SSSDEDDTNHTRQLLSGRIADFSRTRI-----PDGIELK---------
-------PQSTVAEQKDQILGKQIPNTQEGLWSVNNQNYL-----LPDLLQQSQ-ITDSS
VNPPQVPLTCQEPQNKPLTKSPCAESPPAKSST---SSTTSFTSFIDP------------
--RLLPI-------TPPTSPVGP-SCSS------PSSAKPEPVRRENARKGSVVNVNPTN
IRPQSDSPEIRKYKKKFNSEVL

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CAALW---GVNLLVGTENGLWLLDRSGQGRVYTLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHHKPLSVDLTVENGQRL
KVIYGSVVGFHAIDVDSGSVYDLYLPTHIQGTIRPHAI-IILPNTSGMELLLTYEDEGIY
IDIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGEKAIELRSVETGNLEGVFMHKKAQK
LKFLCERNDK-VFFASVQSGGSSQIYFMTLGQNVLFNW----

----MAGPGGWRDREVTDLGHLPDPTGIF

PF07714 // ENSGT00920000148966_3_Domain_1 (30, 316)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANM

ENSGT00920000148966_3_Linker_1_2 (316, 1582)

LHHPFVRDIKNERHVVESLTRHLTGIIKKRQK-KKGIPLIFEREE
AIKEQYTI---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLHTQVRAPRLLQV--QAHVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEAPQAIGSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRRR-RQRRW
EDIFNQPEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKPCISNPKK--
---IEVQERSPS---VPNNQDH------VHHVK----FSS--------------------
--NVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDAVG---D
TDGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNNYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRAYRSHGGSAASEDNAAIGDQEEHAANIGS
ERRGNGGDGGKGVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNEA
SNAIDSGAAPS---------AADDESD-NKDISGS-STQSDFSANHSS------------
----------------PSKGSGTSADANFASA--ILYAGFVEVPEESPKQPFEVNVNPLY
VSPARKKPLIHMYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

CCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRQ-ILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHLIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLPNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDKEVTDLGHLPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX--XXXXXXXXXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX

PF00069 // ENSGT00920000148966_3_Domain_1 (144, 321)

XXXXXXXXXXXXXXXXXXXXXXXXXXXXGLAHLHAHR
VIHRDIKGQNVLLTHTAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRXXXXXXXXXXXXXXXXXXXLCNLQPLEALFVILRENAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLQHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1581)

VQNIKNERHVVESLTKHLTGIIKKRQK-KEGIPLVFERQE
PIKEQHHT--MKRFRGSSCTHELLRLPTSSRCRPLRILRGEPSQPRWLPDD-EPQMQALQ
QLQGEARGDLPPQAEDNIPRPLQKPAKAPKRLHVA-AQVFMPLHAQGKLKAARPLQLHIM
APPRLQRAARVLMPLPPHAKMPRRLPVQA--PLPKKEQQVPEQAQLSKEPKDL---DQVP
EEFQGQEQVPEQQQGQGQAAEQQQMQNQ-PDEQLQQ---NQAPEQAEIQEEAAEPVQA--
EPEAEEA-ELIRV------NAQVVLP--------------------------------LL
SQNHHVLLPL----HLDTQ--LLIPVQKQ--EXXXXXXXXXXXXXXX-XXXX--------
-----XX-----------------------X----------------------------X
----XXXXXX---------------XXX---X-----------------------XXXXX
XXXXXX----------XXXXX----------------------XXX-----XXXXX----
-------XXXXX----XXXX---------XXX-------X--------------------
--------X-XXX-------------------XXX-----------XXXXXXXXXXXXXX
SSSEEESPVTGRRSQSSPPYSTIDQKLLIDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLIPAPAIQ----PPEED--------------------GDYVELYDAAAGADG
---------------------DYDAYEDSYGHASGRDSDQDND-----------------
-------------------------------AHIWPXXXXXXXXXXXXXXXXXXXXXXXX
----XXXXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXX------XXXXX--
-XX---XXXXXXXXXXXXXXXXX---------XXXX-XXXX------------XXXXX--
-----------------XXX-X------------XX---XXXXXXXXXXXXXGFDGENEA
ACAIASGAALS---------ELDDEDE-NKDISES-STLSGFSASPSS------------
----------------ASRGSEGSVDTDFASS--IXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX---XXXXXXXXXXXXX

PF00780 // ENSGT00920000148966_3_Domain_2 (1581, 1930)

XXXXXXXXXXXVNLLLGTRSSLYLMDRSGKAEIMKLIKRR
PFRQIQV-VEPLNLLITISXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTSGLKPVTVDLAVGSEKKL
KIFFSSANGYHIIDAESEVMSDVNLPNNPLKIILSQNI-IILPNCLGIGVMLTFNAETLS
MEANEQLF-KKILEVWKDIPSSVAYECTQRTTGWGQRAIEARSLQPKILENELKRRSIKK
LRFLCTRGDK--------------------------------

---------------------------------------------

PF00069 // ENSGT00920000148966_3_Domain_1 (46, 321)

GRHVKTGQLAAIKVM
NV----------------------------TEEEEEEIKLEINMLKKYSHHRNIATYYGA
FVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKCINFVDS
CLVKNYSHRPSTDTLLKHAF

ENSGT00920000148966_3_Linker_1_2 (321, 1580)

VRDLQNERHIRIMLKDHLDRARKKKGEKDENG-YEYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PPRPQQLQQQQLKDQEKYKMQLQAERQKRI---EQQK
EQ---RKKLEDYQRRERDLQKCQEYQPKWPEMKEDAKSEGKRREGRKCAEQHE-------
NLKHKRP-EESQT------QKKFHRT--------------------------------L-
PKDQTQLLFL----QHDHKEKNLEPQRN--ISNHIPV--GISLEVMK-VDSKKRKRPVLI
RATLNGS--SSSPCTPALPRAALPEQSLCTTIPYVTGPFSEITPLLLTNEPYWGGHISLM
YYANAL-------------PPTL-LRCCPDPRCTKDQNKK---NYTRFRRFKQLDAAICW
LKVMLQSQK-----EQPEKSH-------SSRGSAG-----S--SSQSNRIPSVPSPKN--
---ELFVQNKISPTTTVLKQDK------HS------------------------------
--GTK-QRD-VIQ-----TAYHEI--IAEPP-FSIFQKNTKSKQKNKVPNPKKCKMQNN-
---------------HIMLYTVLDSSLLM---------------------SPGWVLQRES
TA-----TEPPHPTVH----KDSIS--------------------NCNVMLKES----RG
KESPH---------------LKASYYSSS-SDEMGSSD------------DDIQKKNKNP
GLG--GKSSPSTKETGKLLNISYMCNHFNEHVISGNQHNYGRDSLVQQNAPHGEN-----
---------------------------------------------------------V--
-------------QQKNSSSSTA---------SFSP-FIDPRLLPASPPTSPSGCCEYNI
VFIT------------KLLLGTN-----------VQTNVMFILLDF--HLKQ--------
--------------------------G-NKSFI----------SLVCP------------
----------------GLNGKYMHSNIRFCSC--LPFEPITFI--AIPKSPSDFQQ----
-------------FNDFHV

PF00780 // ENSGT00920000148966_3_Domain_2 (1580, 1936)

TPSDPSL-CFIGVNLLVGTEHGLWLLDRSGQGRVYPLISRR
RFYQMDV-LEGLNILITISGKKNKLRVYYLSWLRNKILRNDPDVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--SSLHHKPLFVDLTVENGQRL
KVIYGSAVGFHAIDVDSGTAYDLYLPTHVSSLASVYAFQIYQYKCCAISVLICHSDKHCY
LADYGKIINLKLIETMKGPTDAASYLQSNQIMGWGEKAIELRSGETGSLEGVFMHKKAQK
LKFLCERNDK-VFFSSVQSGGCSQIYFMTLGQNVLFNW----

----MAGPGGWRDKEITDLGHLPDPTGI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 321)

FSLDKTIGFGTYGRIYLGLHEKTGVLTAVKVM
----NARKXXXXXXXXXXXXXXXXXXXXXXXXDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKMSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRXXXXXXXXXXXXXXXXXXXLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1555)

VQKIKNEKHVVESLKKHLTGIIKKRQ---NKGPLVFEREE
AIQERYTT---RRFRRAICTHELLRLPTSSRCRPLRVVYGEPSQPRWLPDQEEPQVQALH
HLQGAAKVFTPLKSQASTPKPLQGQIQAPRRLHGA-AQVFMPLHVQAKSRAFSPIPMQLR
APPRLRRTARMFMPLQVQIKAPRPPRVKV---EELKEQQVQIQNQGSKEPQDL---DQVP
EEFQRQEQVPEQQQRQGQAPEQHQRQNQVPEQQMAQ---NQAPEEPEVQEQAAEPAQADA
EVEAEQP-ESLQV------HAQLFLP--------------------------------LM
SQNHHVLLPL----HLDTQ--LLIPVEG--HSEASPQPQNWALEPPQAVGAI--------
QALIEGL-----------SRDLLRAPNSHDS--KPLGPLQTLMESLSSN----------M
FYSQPEQVQK-KKSKVFSLREALAKRLSPKRFRAKLTRKSEEFELSDLEARRQR-RQRRW
EDIFNQHEE------LKQVAN-EKEDESSDNDEVFHSIQAE--VQIEPLQPYVPNPKA--
---SDXXXXXXX---XXXXXXX------XXXXX--------------------------X
XXXXX-XXX-XXG-------------QAQKP-SDI-------RQR-SLHNPQNCPETSES
S-SEEASPVVGRRSQSSPPYSTIDQKLLVDVHXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX------XXXX--------------------XXXXXXXXXXXXXXX
XXXX----------------XXXXXXXXX-XX-XX-XXXXXXXXXXXXXXXXXXXXXXX-
-----------------XXXXXXXXXXXXXXXXXXXXRRYGRGGRKQ----EGRDEN---
-------DRGDGNF----------RGYEYRRAYGKNGASAAGEGSEAFGD---HGANIGN
GRKSKEGKGGKVVSGANEEIDTL---------ELNGEENYS-------------DTDD--
-----------------PVL-A------------QA---ASQ--DF--GDQQEPGGRSEA
SNAVTLGAALS---------ASDDEND-IIDISEA-STESGFSASYSF------------
----------------PSYGSE-TANADFASS--ILCAGLVEVPEKSPELPSDV

PF00780 // ENSGT00920000148966_3_Domain_2 (1555, 1936)

NVNPLC
ASSACEKPLIHMYEKEFTSEICCGSLWXXXXXXXXX---XXXXXXXXXXXXXXXXXIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLSWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAGAPKSFDENTAIKVICIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKARNL--KNRVQVTVDLAVGSEKKL
KIFCSSADGYHVIDAESEVMSDVTLPNNXXXXXXXXXX-XXXXXXXXXXMMLTFA--ALS
VEANEQL--KKILEVWKDIPSSVAYECTQRTTGWGQKAIEVRSSQSRVLENELKRRAIKK
LRFLCTRGDK-LFFTSTLNNRHSRVYFMTIGKLEELQSNNEV

----MAGPGGWRDKEITDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGALTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHEHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRC
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSGGWSRKFHNFMEK
CMIKNFLFRPTSANMLVHPFVQDIKNEQHVVESLTKHLTGIIKKRQKKDHAQGPE-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------XRP---QQVQTQVSKKQQAQGQPQASGEPQDL---DQVP
EEFQRQDQVPEQQQRHGRVPEQQQRQNHIPEQPLQQ---NGAPEQPEVQEQAAEPTQA--
EMEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLVPVEG--QTEGSPQAQAWALDPTQAVGSV--------
QALIEGL-----------SRDLLRAPNAHNS--KPLGPLQILMENLASD----------V
FYSQPEQARK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEAFELSDLEAHRQ-RRQCRW
EDIFNQQEE-----ELRQVANDKEDESSDNDEAFHSIQA-E--VQIEPLQPYIPEPKE--
---NEVQERSAS---MPHNKDR------VHRVK----FSS--------------------
--SVP-QRS-VLE-------------QAQKP-IDI-------RQRS-SQNPQNCPAASES
S-SEEASPVIRRRSQSSPPYSTIDQSLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTP----------A-----------------------PVVQPPEEDGDY-VE
--LYD-AGADTDGDD----DSNDAYEDSYDHD-N--GSDELNDQLDQANDVGEDHYDDD-
-----------------NDEVIDDKGNNPDDASSWPRPSCGRGRSYKQDGKDGSD-----
--------RGEGSF----------SSYGSQRVNRSHGGSAASGDSAAIGDHEEHTANVGS
GRRGKESNGNEGVSGTNEESEAQ---------ELNGGENCSET----------DDP----
------------------IL-E------------RP---VFQ--EF-EHQLEESGGRSEA
SNAIAPGAAPA---------VPDAEND-TVDISE-VSTESGFSANHSS------------
----------------PSNDSERTANADFASA--ILYAGLVEVPEKSSKRPSDVNVNPLY
VSYECKKPLIHMYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_3 (1582, 1691)

CCGSLWG-VNLLLGTRSNLYLMDRSG--KADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKS
IDKLTGCEHFSV------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPKPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPPLRRAARVLMPLQAQVRAPRLLQI--QSQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDLEARRQR-RQHKW
EDIFYQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQIEPLKPYISNPKK--
---IEVQEISPS---VPNNQDH------AHHVK----FSS--------------------
--SIP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEDSPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDASA---D
TDGDD-DD------------ESNDTFEDTYDHANGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNNYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERRGSEGDGGKGVVRTSEESGAL---------GLNGEENCS-------------ETDG--
-----------------PGL-K------------RP---ASQ--DF-EYLQEEPGGGNET
SNAIDSGAAPS---------APDHESD-NKDISES-STQSDFSANHSS------------
----------------PSKGSGMSADANFASA--ILYAGFVEVPEESPKQSSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYDV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTALPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMSRNQSLKEDWIAYICREILQGLVHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIYCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTKHLTGIIKKRQK--KGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVRALQ
QLQGAARVFMPLQALDITPRPLQQQAQAPQRLQGA-ARVFMPLQAQVKAKASRPLQMQIK
APPRLRKAARVLMPLQAQGRAPRPLQVRKVQAQVPKKQQAQVQVQASEQPQDL---DQVP
EEFQGQDQVPEHQQRQGQVPEQQQRQNQVPEQQLEQ---NRAPENPEVQEQAAEPPQA--
ETEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDSQ--VLIPVEG--QTEGLPQGQAWALEPPQVVGSV--------
QALIEGL-----------SRDLLRAPNSHNS--KPLGPLQTLMENLSSN----------M
FYSQPEQARK-KKSKVFSLRQALAKRLSPKRFRTKSSRRPEELDLSDLEACRQR-RQRRW
EDIFNQHEE-----ELRQVEN-DKENESSDNDEVFHSIQAE--VQIEPWQPYVPSPKR--
---NEVQERTVS---MPYKQNH------AHHVK----FSL--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNSQNCPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDASADID-
--GND--------------DDSNDAYEDTYDHDNGNNDLSNQVDQVNDGYKNHDDDGND-
-----------------DESVDD--TDNCDNAPSWPRASYGRDGRYKQ---DGG------
--------DGKVVY----------RGYGSLRASRRHGGRAASGGSAAIGDQEGHKANIGS
GRRGSRGNGGKGVSGTNEESGAL---------EFNGEENFS-------------EMYG--
-----------------PRF-K------------RL---ASQ--DF-EHQQEEPGGRRKT
SNAIDSGAATP---------VLDDEND-CKDTSES-STQLGFSANHSS------------
----------------PSKGSGRVADADFASA--VLYAGFVEVPEEIPKLPSEVNVNPLY
ISRACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKT
INKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKTFDESTAIKVICTDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KVFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
IEANEQLF-KKILEVWKDIPSSVAFECTQRTTGWDQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGI

----MAGPGGWRDKEIADLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFIILRESAPTVKSGGWSRKFHNFMEK
CMIKNFLFRPTSANMLVHPFVQDIKNEQHVVESLTKHLTGIIKKRQKKGRT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLLDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGSFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVAFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRS
SYDYRSDVWSVGITAIEMAEGAPPLWNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSENMLHHPFVENIKNEQHVVESLTKHLTGIIKKRQNKGRDGKSHLT---
-----------FRFFNVVCHQFI-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHSHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRINGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHDFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1591)

VRNIKNEGHVVESLKKHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQNGTPRPLQGQAQAPQQVQGA-ARMFMPLQAQVKAKASMPLQMQMK
APPRPQRAACMFMPLQAQVKAPRPQQV--QAQVS-KKQQAQGQPQASGEPQDL---DQVP
EEFQRQDRVPEQQQRHGRVPEQHQRQNHIPEQPLQP---NGAPEQPEVQEQAAEPIQA--
EVEAEEP-ESLQV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLVPVEG--QLEWSPRAQAWALDPTQAVGSV--------
QALIEGL-----------SRDLLRAPNAHNS--KPLGPLQILMENLASD----------M
FYSQPEQPRK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEVFELSDLEAHRQR-RQCRW
EDIFNQHEE-----ELRQVAN-DKEDESSDNDEAFHSIQAE--VQIEPLQPYIPDPKE--
---NEVQERSAS---MPCNQDR------VHRVT----FSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNPQNCPAASES
S-SEETSPVIRRRSQSSPPYSTIDQSLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGADTD-
--------------------DSNDAYEDSYDHDNGSDELNDQVDQADVVGEDHDDDDND-
-----------------EVIDDKG--NNPDDASSWPRPSCGRGRSY---KQDGKDGSD--
--------RGEGSF----------SGYGSQRVNRSHGGSAALGAGAAIGDHEEHRANVGS
GRRGKESNGNEGVSGTNEESEAQ---------ELNGGENCS-------------ETDD--
-----------------PIL-E------------RP---AFQ--EF-EHQLEEAGGRSEA
SNAIAPGAAPA---------VPDAQND-TVDISEV-STESGFSASHSS------------
----------------PSNDSERTANADFASA--ILYAGLVEVPEKSSKRPSDVNVNPLY
VSHECRKPLIHMYEKEFTSEICCGSLWG-T

PF00780 // ENSGT00920000148966_3_Domain_2 (1591, 1927)

GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIVPQNI-IILPDSLGIGMMLTFNAESLS
VEANEQLF-KNILDVWKDIPSSVAFECSQRTTGWGQKAIEVRSSQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKAIGLGTYGRIYLGLHEKTGSLTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGYRHQLWIVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFIILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSGNMLRHPFVENIKNERHIVESLTKHLTGIIKKRQKKGRDSKVLYHSDK
RFNSLFLV---SYLFKNLI------------------------DGGWRDGSAGKR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

---------------------------------------------GRHVKTG

PF07714 // ENSGT00920000148966_3_Domain_1 (53, 317)

QLAAIKVM
NV----------------------------TEDEEDEIKLEINMLKKYSHHRNIATYYGA
FVKKSPVGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHSHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKNYMHRPSTETLL

ENSGT00920000148966_3_Linker_1_2 (317, 1583)

KHSFIRDLQNERQVRIMLKDHLDRTRKKKGEKEETE-YEYSGSE
EDED-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKSRSE--------
-----------------------PHRQQHLQQQQLKDQEKYKKQLLAERQKRI---EQQK
EQ---RKRLEDHQKREQELRKLQEGEHHWPEIKDILRKEEKGREDNRIEDERCKVADG--
---QKKS-ERKQV------QFQHEFA--------------------------------LW
L---GP--LL----HLQS-------------SEKWICLEGWSLNLIM-VGPK--------
ETKYPGSDMKGSVMHPNWPRVCMIKQQKPSL--GRVGPLDFWKPPVSPT----------D
LNPAPPQIMS---------------VCSPEKV------------------------LYKF
QDYLHA------------FLV----------------------PSKSPLREYAIKI----
-------KRHIP---LPLYPNI------HHFLS----KHL--------------------
--SYP-DHV-ILQ-----TSSHSSKTSSDRPFLDT-----------SSRNPWETP-----
--TEECWPKPNQRSQPAAPSPCFLQTCSLGPA-----LPGTHSPPLSAHTSS--------
---VRARSSVPAAVMS----PLRLF-------------------TSHFGFLFQKKIE---
---------------------------DAQHNKKVHRTLPKDQTQLLSLQHDHKQKNKEP
PKSVAVAPHPSPKSIRKEIGGEQLEAARPTSSLAWPKPDPGSTLAGG--ASRGH---EIA
----AH--TTSGTC-----------------AQRVPGT----------------------
-----SFSGGKQTSTH-SLSGEMHKHL-----YLSAERLGV-DLPAILLLS-QKKKKQ--
-----------------QEIGN------------HPTTKISIVFYFPQHLIQHSKHGKSS
INTIDLWFLNI---------GILKKSN-NSELIAITATLNTFNPKQD-------------
-------------------------------S--IQWGTIRQVQNQIKKTRQS-------
---LETNLALRFKSKSFEIKQI

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CLILI---GVNLLVGTENGLWLLDRSGQGRVYSLISIR
RFPTNGCSGKDSNVLITISGKKNKLRVYYLSWLRNKILHNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------AF--ISLHQKPLSVDLTVENGQRL
KVIYGSVVGFHAIDVDSGTVYDLYLPTHIQGNIRPHAI-IILPNTSGMELLLTYEDEGVY
INIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGDKAIELRSVETGNLEGVFMHKKAQK
LKFLCERNDKKVFFASVQSGGSSQIYFMTLGQNVLFNW----

---------------------------------------YYP

PF00069 // ENSGT00920000148966_3_Domain_1 (43, 321)

VFQGLHEKTGAFTAVKVM
----NARKTPLPEIGKRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1582)

VQNIKNEGHVVESLKKHLTGIIKKRQKKEKGIPLVFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQDNAPRPLQGQAQAPQRLQGA-ARVFMPLQAQVKAKASRPLQMQIK
APPRLRRAAWMLMPLQAQVKAPRPLQV--QSQVP-KEQQAQAQPQTSEEPQDL---DQVP
EEFQRQDQVPEQQQRQGQAPEQHQRQNQVPEQQLEL---NQVPEQPEVQEQAAEPTQA--
ETEAEQP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVKG--QTEGSAQAQAWALEPPQAVGSV--------
QELIEGL-----------SRNLLRAPNSHNS--KPLGPLQTLMENLSSN----------M
FYSQPEQARK-KKSKVSSLRQALAKRLSPKRFRAKVSRRPEDLELSDVEACRRR-RQRRW
EDIFNQHEE-----ELRQVAN-DKEDESSDNDEVFHSIQAE--VQIEPLQPYIPNPKE--
---VRVQERS------TYNQDC------AQRVK----FSS--------------------
--NVP-QQS-VLE-------------QALKP-TDI-------RQR-SSQNPQNCPAASES
S-SEEESPVTWRRSQSSPPYSTIDQKLLVDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDTGA---D
TDGDD-DD-------------SNDAYEDTYDHDNSNDDLDNKVDQANDVGEDHGDNDNG-
-----------------EAIDDKENNHDD--APCWPRPSYGRDGSC---KQDGSD-----
--------GGEETC----------SSYGSQRVHRSHEGNVASGGSAAIVDVEELGANIGN
GRRVKEVNEGKGVSEANEESGAL---------ELSGGENHS-------------ETDG--
-----------------QGL-E------------RP---ISQ--DF-EHQQKEPGGRNEA
SNAIASGAAAA---------APDDEND-SMDISEA-STQSGFSASYSS------------
----------------PSNGFWRAANADFASA--ILYAGLVEAPEKSPKRPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

CCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTVGHKPVTVDLAIGSEKRL
KIFFSSTDGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDSLGIGMMLTFNAEALS
LEANEQLF-KKILEVWKDIPSSVAYECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGNLEELQNNYGV

---------------------------------------YYPM

PF00069 // ENSGT00920000148966_3_Domain_1 (44, 321)

FQGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRDSAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VRNIKNEGHVVESLKKHLTGIIKKRQKKEKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQDNAPRPLQGQAQAPQRLQGA-ARVFMPLQAQ------------IK
APPRLRRAAWMLMPLQAQVKAPRPLQV--QAQVP-KEQQAQAQPQTAEEPQDL---DQVP
EEFQGQDQVPEQQQRQGQAPEQQQGQNQVPEQQLEQ---NQLPEQPEVQEQAAEPTQA--
ETESEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTEGSPQAQAWALEPPQAVGSV--------
QELMEGL-----------SRDLLRAPNSHNS--KPLGPLQTLMENLSSN----------M
FYSQPEQAQK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEEFELSDLEACRRRRRQRRW
EDIFNQHEE-----DLRQVAN-DKGDESSDNDEVFHSIQAE--VQIEPLQPYVPNPKG--
---NEVQERSTS---VPYNQNC------AHRVK----FSS--------------KSLGKL
EISVP-QQS-VLE-------------QAQKP-IDI-------RQR-SSQNPQNCPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLVDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----RNPY------------------------IVLLIFKCYWVD
IHGRT-DYKLFNIFSFLPNKKINQEFHHQLCQKYGLNHFCGCE-----------------
-------------------VANACSLLFK--QPAQNKPSCGRDGSC---KQDGRDVSD--
--------GGEETC----------SSCGSQRVSRGHGESVASGGSAAIGDHEELGANVSN
GTRVKEINGGKGISGTNEESGAL---------EPSQ-------------------IVS--
-----------------PML-----------------------------DHSEPSSRSEA
SNAIASVAAPT---------APDDEND-SIDISEA-STQSGFSATHSS------------
----------------PSNGSGRAANADFASS----------------------------
--ISCKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDENTAI--------------
-----------------------------------KVF--PTVGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGSFTAIKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREVLQGLAHLHAHQ
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIGCDEDPSR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSGNMLHHPFVENIRNEQHIVESLTKHLTGIIKKRQKKGRDNKVLYNSEK
RGPYIYLLFLVSYLFKILV------------------------GGGWRGGSAGERF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-----------------ISLHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGSFTAIKVM
----N---TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREVLQGLAHLHAHQ
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIGCDEDPSR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSGNMLHHPFVENIRNEQHIVESLTKHLTGIIKKRQKKGRDNKVLYNSEK
RGPYIYLLFLVSYLFKILV------------------------GGGWRGGSAGERF----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

------------------------------------------VFQGLHEKTGAFTAVKVM
----NARKTPLPEIG

PF07714 // ENSGT00920000148966_3_Domain_1 (76, 316)

RRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEQ
CMIKNFLIRPTSANM

ENSGT00920000148966_3_Linker_1_2 (316, 1591)

LHHPFVQNIKHERHVVESLTKHLTGIIKKRQK-KKGIPLVFEREE
AIKEQYTM---RRFRGPSCTHELLKLPTSSRCRPLRVLHGEPSQPRWLPDR-EPQVQALQ
QLQGAARVLMPLQAVDNTPRLLQGQAQAPQRLQGA-ARVFMPLQAQVKAKTSRPLQMHLK
APPRLRKVAGVFMPLQAQGKIPRPLRAQAQAQVP-KEQQAQAQDQPSEQPQDL---DQVP
EEFQGQGQVPEQRQGQGQAPGQQQRQNQVPEQNL-------EPEQPEVQEEASET-EP--
EAEEEEP-ESLQV------QALVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEE--QTEGLSLAQAWVLEPSQAVSSV--------
QALIEGL-----------SRDLLRAPNSDEL--RPLGPLQTLLENLSSN----------V
FYSQPEQARK-KKSRVSSLRQALAKRLSPKRFRAKSSRRPEELELSDFEAHRQR-RQRRW
EEIFNQHEE-----DVRPVENDKEDESSDNDDEVFHSIQAE--VQIEPSQPCIPNPNG--
---DEVQEGSIA---MPCNQDR------AHHVT----FSS--------------SI----
--SVP-QRS-RLG-------------QAPKP-IDI-------RQRRCLQNPRNGPAATES
S-SEEESPVPRRRSQSSPPYSTIDQNLLIDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----LTVRN--------------------GVAKEVYNLTKKSHG
TVE-P-IVKLPWHTYVD----QKNSFK------------KNILIHIAKACLDIVDVYK--
-------------------AHANSVTFTNFQLVLLIRASYRRDGSY---KQDGSDGREVY
----RSYK---RSY----------K-----SYSRHYGGSAASGASMATGDQEGYEANIGS
GRNSR-DNAGQGVSGTNENDGAL---------ELSGRENRS-------------GRRG--
-----------------PRL-E------------RL---VSL--DF-EHQQEEPGHGSEI
SNVIASGAASP---------APDDESD-NRYIGESSSTPSDFSAACSS------------
----------------PSTGFRRSADDDVDSA--ILYAGFVEVPEESPDQPFEVNVNPLC
ASSAYKKPLIHMYEKEFTSEICCGSLWG-T

PF00780 // ENSGT00920000148966_3_Domain_2 (1591, 1927)

GVNLLLGTRSNLYLMDRSGKAEITKLIKRR
PFRQIQV-VESLNLLITISGRKNRLRVYHLTWLRNKILNNDPGSKRRQEEMLKTEDACKA
IDKLTGCEHFSVL-QHEETTYIAVALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSSTGYHSIDAESEVMSDVTLPNNPLEIIVSQNI-IILPDGLGIGMMLTFNAEALS
AEENEQLF-KKILDVWKDIPSSIALECSQRTTGWGQMAIEARSLQPRVLESELKRRSIKK
LRFLCSRGDK-VFFTSILRNRHSRVYFMTLGELEELQSNPGD

----MAGPGGWRDKEVTDLGHLPXXXXXXXXXXXXXXXXXXXXX

PF00069 // ENSGT00920000148966_3_Domain_1 (45, 321)

XGLHEKTGAFTAVKVM
----NARK-PLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMSRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1617)

VRDIKNERHVIESLTKHLTGVIKKRQKKXXXXXXXXX---
XXXKQYT---MRRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPRVQALQ
QLQGAARVFMPLQAQDNAPRSLQGQAQASQRLQGA-ARVFMPLQAQVKVKASRPLQMQIK
APPRLRRAARVLMPLQAQGKAPRPLQV---QAQVPKEQQVQVQTQASKEPQDL---DQVP
EEFQGQDQVPDQQPRQGQVPEQQPRQNEVPEHQLEQ---NQAHEQPEVQEQAAEPTQA--
ETEADGP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTDGSFQAQAWALEPSQTVGSV--------
QALIEGL-----------SRDLLRAPNSHNS--KPLGPLQTLMENLSSN----------M
FYFQPEHVRK-KKSKVSSLKQALAKRLSPKRFRAKSSQRPEELELSDLEAHRR-RRQRRW
EDIFNQHEE-----ELREVENXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXX--
---XXVQEIPTS---LPYDQDR------VHHVK----FSL--------------------
--SVS-RQS-LLE-------------QAQKP-IDI-------RQRS-SQNPQNYPAASES
--SEEEIPVTRRRSQSSPPYSTIDQKLLVDVHXXXXXXXXXXXXXXX--XXXXXXXXXXX
XXXXXXXXXXXXXXXX----X------------------------XXXXXXXXXXXXXXX
X-XXX-XXXXXXX------XXXXXXXXXXXXXXXXX-XXX------XXXXXXXXXXXXX-
-----------------XXXXXXXXXXXXXXXXXXXXASCNRDGSCKEDGSDGS------
-------DGKEGVC----------RGNGSHRTSRRSGGSAASAANTATEEQEGYGANIGS
ATRDNRYMGSKAVSGTNEESGGL---------ELNGRENCSET-------------DG--
-----------------PGX-X------------XX---XXX--XX-XXXXXGPGGGSET
LGTIASGVA-P---------LAPDEND-NKDLSES-LTQSGFPANYSF------------
----------------PSKGSGRSADAEFASA--ILYTGFVEVPEKSLKRPSEVNVNPLY
VSPACKKPLIHMYEXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX--XXXXXXX

PF00780 // ENSGT00920000148966_3_Domain_2 (1617, 1936)

XXXX
XXXXXXX-XXXXXXXXXXXXRKNRLRVYHLTWLRNKILNNDPGSKRRQEEMLKTEEAYKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVICIDQSADSEGD
YMSYEAYVRILAKIQAADPANRFKRPDELLHLLKLKARNLKTANRVQVLIDLAIGSEKRL
KIFFSSANGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDVPSSAAFECTQRTTGWGQKAIEVRSLQSRILESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGHRHQLWMVMELCAAGSVTDVVRMTKNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPFVRNIKNERHVVESLTKHLTGIIKKRQKKGIIYEVSFH---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGFGTFGKIYLGLHEKTGTFTAVKVM
----NARKTPLPEIGRRVRVNKYQRSVGWRYSDEEEDLRTELNFLRKYSFHKNIVSFYGA
FFKLSPPGYRHQLWMVMELCAAGSVTDVVRMTRNQSLKENWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTRNAEVKLVDFGVSAQVSKATGRRNSFIGTPYWMAPEVINCDEDPRN
SYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALFVILRESAPTVKSSGWSRKFHDFMEK
CMIKNFLFRPTSANLLQHPFVKDIKNERHVVESLTKHLKGIIKKRQKKGRI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

----MAGPGSWRDKEVTDLGQLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKAIGLGTYGRIFLGIHEKTGSLVAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVTFYGA
FFKLNPPGHQHQLWMVMELCAAGSVTDIVRMTRNQSLKEDWIAYICREILQGLAHLHAHQ
VIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIHCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPKVKSSGWSRKFQNFMEN
CMIKNFLFRPTSGNMLRHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VHDIKNERRVVESLTKHLTGIIQKRE--KKGIPVAFEGEE
AVKEQYIT---RRFRWPSCTPELLRVPTSSRCRPLRILHGEPSQPRWLPDQEDPQDQELQ
QLQKAAGVFMPLHSQDNTPKLFPKQVEVAQYLRGA-AQVVMPVLV------------QVE
AASQVSKAAQMLMSLPTQDNKATSPEVQA---PIAEGQQAQHEALETEQPKDL---DQVP
EEFQGQDRAPEQ-PRQDQAAEQQQRQNPVPEQPPEE---NREPEQAEVQEEAVEPPQA--
EVQAKEP-EVIQV------HAQVLLP--------------------------------LL
SQNHHVLLPL----HLDRQ--LLIPVGE--QNQEAPRAQAWDLEASRAVGAV--------
QALIEGL-----------SRDLLRAPNAFIT--KPLGPLQIFLENLCTD----------G
FYSEPEPTQK-KKSKVASLRKAIAKRLRPKRFRAKALWRLEDFEFSDVETSRRR-RHRRW
EDIFNQHEE-----QLRRVEN-DREDDSSDNDEVFHSIQAE--VQIEP---HAANPAG--
---NEVQERSAP---MPGNRNR------THRVK----FSP--------------SVGEEE
P-SLE-EAQ-LP--------------QQQQP-MDI-------RPRN-CLNPHNFQAESDS
S-SEEDSPVTRRKSQSSPPYSTIDQKLLIDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFWDDWIMPTRPAR----PPEED--------------------GDYVELYDADANADG
DEE-----------------VANDAYEDPRDGANGHDDMNNQLDQANGYEGHGAAAYNG-
-----------------G-----DIDGNHGAAFNGPRANYPRAGILKNGNNDGRGL----
---------NRGAF----------GAYGDNAARGYHG--AAGEAGAALGNHEVHGANGGN
RRG----NRNREANGRNEENGAF-------------------------------------
------------------GV-D------------QH---VFP--DF-EHEESDRGT--ET
SDSIALEITS-----------LDGEQ--S-NGRPVSSTTMGFPLRRSS------------
----------------PRG-------SDFGS-----------------------------
-DISYNSPILHVYEKEFSSEVY

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTQSHLYLMDRSGKADIVKLIKRR
PFRQIQV-VEQLNLLITISGNKNRLRVYHLSWLRNKILNNDPKSKKRQKAMRKKEEACKA
IDKLIGCEHFSVL-QHEETTYIAVAVKSSIHLFAWAPKSFDENTAIK-------------
------------------------------------VF--STRDLKPVTVDLAVGSEKTL
KIFFSSANGYHIIDAESEVMSDVTLPNN--------NV-VILPDCLGLGVMLSLNAETAS
EEANEQLL-KKILDVWKDIPSSVAFECTKRITGWDQKAIEVRSLQSTILENELKRRSIKK
LRFLCARGDK-MFFASTLSNQHSRVYLMSLGKLEELHRSYAV

-----------------------DPTGI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 321)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VRNIKNEGHVVESFKKHLTGIIKKRQK-KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQDSTPRPLQGQAQAPQRLQGA-ARVFMPLQAQVKAKASRPLQMQMK
APPRLRRAGWMLMPLQAQVKVPRPLQS--------KEQQAQAQPQASKEPQDL---DQVP
EEFQGQDHVPNQQQMQGQVPEQQQMQTQVPEQQLEQ---IRGPEQPVQ-EHAAEPMQ---
-ETAYEP-ESLRV------HAQVL-P--------------------------------LL
S-QHHVLLPL----IWNTX--XXXXXXX--XXXXXXXXXXXXXXXXXXXXXX--------
XXXXXXX-----------XXXXXX--XXXXX--XXXXXXXXXXXXXXXX----------X
XXXXXXXXXX-XXKKSKSSRQALAKRLSPKRFRAKLSRRPEE-ELSDLEACRRR-HQRRW
EDIFNQHEE-----E-RQVAN-DKEDESSDNDEVFHSIQAE--VQIEPLQPYIPNPKE--
---NEVQEKSAS---VPYNQDR------VHHVK----FSL--------------XXXXXX
XXXXX-XXX-XX----------------------X-------XXX-XXXXXXXXXXXXES
S-SEEESPVTRRRSQSSPPYSTIDQKLLVDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDAG---AD
TDGDD-DD-------------SNDAYEDTYDHDNGSDDL---------------------
------------------------DIQID--Q--ANDIGEDHDGXX---XXXXXXXXXXX
----XXXXXXXXXX----------XXXXXXXXXXXXXGGNAASGDSAIGDHEGHRANTGS
GRRGKESNEGERVSGTNEESEAL---------ELSGGENCS-------------EMDD--
-----------------PVL-E------------RP---ASQ--DF-EHQLEEPCGRSEA
SNAIASDAALV---------APDDEND-SMDISEV-STESGFSASHSS------------
----------------PSNGSERAANTDFASA--ILYAGLVEVSEKSSKRPSEVNVNPLY
VSPACKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIK-VCIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAYECSQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGKRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHTAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMGK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1582)

VHNIKNERHVVESLTKHLTAIIKKRQ--KKGIPLIFEREE
AIKEHYTI---KRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDQEDSQVQALQ
QLQGAAKMHMPLQAQENAPRPLQRQAQAPQRLQGA-AQVFMPLQAQGKVKAPRPLQMHIR
APPRLRRAARVLMPLQAQGKVPRPLLIQA--RVPKREQQIQGQAQISEQPQDL---DQVP
EEFQGQEQVPEPQQRQGQAPEQQQIQNQVPEEQLEQ---NEAPEEAEVQEQAVEPTQA--
EPDAEEP-ETIRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVQK--QTEGVPQAQAWALEPPQAVGSI--------
QALIEGL-----------SRDLLRAPHSYNS--KPLGPLQTLMENLSAN----------I
FYSQPEQARK-KKSKVSSLRQALAKRLSPKRFRAKSSRKAEELELSDGETRRRR-RQRRW
EEIFNQHEE-----ELRQVEN-DKEDESSDNDEVFHSIQAE--VQIEPLQPDDADPKG--
---NEVQEASVS---VPCNQDR------AHRVK----FSS--------------------
--SVL-QLS-LLE-------------EAEKP-IEN-------RER-SSQNPENCPAASES
S-SEEESPVTGRRSQSSPPYSTIDQKLLIDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLIPAPVVQ----PPEED--------------------GDYVELYDAGAGTEG
DDG-----------------DSNDAYEDTYDHANGRDGLDNQFDQANFVCKGHGGQDNT-
-----------------DEFGD--VANNRNDAPIWPRASYGRNGSS---EQDGYDGKE--
-----------GAG----------SGRGIYRSSRRHGAS---------------------
------------------------------------------------------------
------------------------------------------------AFCEELGAGDEA
SYAMASGAAPS---------ELDDGDD-NKDISES-STLSGFSASHSS------------
----------------ASRGSEGSVDTDFASA--ILYAGFVEVPEELPKRPSDVNVNPLY
VSSASKKPLIHVYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

CCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLGHKPVTVDLAVGSEKRL
KVFFSSANGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGVMLTFNAEALS
VEANEQLF-KKILEVWKDIPSSVAFECTQRTTGWGQKAIEARSLQAKVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYDV

---------------------------------------------

PF00069 // ENSGT00920000148966_3_Domain_1 (46, 321)

GRHVKTGQLAAIKVM
NV----------------------------TENEEEEIKLEINMLKKYSHHRNIATYYGA
FVKKSPAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKNYLHRPPTETLLKHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

IRDMQNERQVRIMLKDHLDRTRKKKGEREETD-YDYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PH----RQQQQLKDQEKYKKQLLTERQKRI---EQQK
EQ---RRRLEDHQRREQELRRQQECEQRWPEAKDVQRKEERCKEDKRAVED-DERFIVDG
QRKSE--------------KKQHELNIVQRTISFSQIKMKWRKKKVEDVQH-NKRVHRTL
PKDQTQLL----SLQHDHKQKK----------K----------EPSKSSKYH--------
--------------K-----G-NSAS-----------------LSLSSS----YGRQ--A
E------DRRKR--SDGT------------------------------------------
---------------------------------------------QPSLQWPVVLGHDIT
PQARVGSGSSSSP-CTPALQRAVVVQVLHQNLLKKLLVS----TTDVR--SMYLRQYTKE
HSGFT-QTERIRGTNLEYFRYNIIIIPKHTP---------TPKATRLQAFINATWVRNE-
IQNEEQPPKVPERTTSKFYGRDQ-PG---------------------------HQRCH--
---------------------SREELGLQSFKRSDTGLKRPIFLFSNSHQ----------
------LSPGGHALKLN---SS---------STPGSKQWEMGSHQSGRPTSG-DSQVKDS
SVTMSR--VPIMRK---PEHSL---------NCLGFVSFCS-------------------
------YERA-INTLKLILLSPVSFAKGKDSTGSFWKAADYSSSSDEVG-----------
------S-------SDEDDMNHMRTLHSSVILLHVLPFLPTSTSSDQREIYPGWQRSHTL
PVSHHSIRFPNSVSVQDQILGKQISSTQEGLWSINNQNYL-----LPDLLQQSQ-ISDSS
VNTPKVPLTSQEPQNKSVNKTPSTESTPSKSST---SSTTSFTSFIDP------------
--RLLPI-------TPPTSPVGP-PCSSFCVSFSASSAKPEPVRRENARKGSVVNVNPTN
IRPQSDSPEIRKYKKKF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

NSEVLCAALWVSTGVNLLVGTENGLWLLDRSGQGRVYSLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKNSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHHKPLSVDLTVENGQRL
KVIYGSLVGFHAIDVDSGSVYDLYLPTHIQGTIRPHAI-IILPNTSGMELLLAYEDEGIY
IDIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGEKAIELRSVETGNLEGVFMHKKAQK
LKFLCERNDK-VFFASVQSGGSSQIYFMTLGQNVLFNW----

-ECDCTPASVWRK---MRLSSLMQP

PF00069 // ENSGT00920000148966_3_Domain_1 (26, 321)

RNVETLLQRCGNSNWKEKYRGRHVKTGQLAAIKVM
NV----------------------------TENEEEEIKLEINMLKKYSHHRNIATYYGA
FVKKSPAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKNYLHRPSTETLLKHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

IRDMQNERQVRIMLKDHLDRTRKKKGEKEETD-YDYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PQ----RQQQQLKDQEKYKKQLLTERQKRI---EQQK
EQ---RRRLEDHQRREQELRRQQECEQRWAEAKDVQRREERCKEDKRAVED-DERFIADG
QRKSE--------------KKQENFQ-----------------KKVEEVQH-NRKGHRTL
PKDQTQLL----SLQHDHKQKK----------K----------EPSKSSNSA--------
--------------V-----H-LPSSNTTKEVPEY--------AYSPAS----RAAK--A
E------DRRKR--SDGT------------------------------------------
---------------------------------------------QPALQWPAALGHDAM
PQARVGSGSSSSP-CTPALQRAVLVQVCHYCVISLPAGNCPVTHTQVSDPAEFLSHLNCE
SAKLI-P--------SPLTSRNSFLVRCRTP---------KLEFRKKSQKDDVFWS--G-
SQSGEQPPKVPERTTSKFYSRDQ-PG---------------------------QQRCH--
---------------------SRRKNQTLT------AENLVPWPRSNSHQ----------
------LSPGGHALKVN---SSS--------STAGNKPWEMASHQNSRPTSG-DSQVNGS
SLKTCK--IPSHKK---ESGT----------EKKGTRTLQNA------------------
-----QMHEA-AVIKLAKLPNTNLNLRELEFYPPSLKAADYSSSSDEAS-----------
-------------SSDEDDTNHARNGVSRLIPARFT-FYAKSHPRTSVKLK---------
--------------------------HSLAYWTGV-----------PDGI----------
ELKP--------QSTVAEQKTPSTESTPSKSST---SSTTSFTSFIDP------------
--RLLPI-------TPPTSPVGP-PCSS------SSSAKPEPVRRENARKGSVVNVNPTN
IRPQSDSPEIRKYKKKF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

NSEVLCAALWA-TGVNLLVGTENGLWLLDRSGQGRVYSLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHHKPLSVDLTVENGQRL
KVIYGSLVGFHAIDVDSGSVYDLYLPTHIQGTIRPHAI-IILPNTSGMELLLAYEDEGIY
IDIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGEKAIELRSVETGNLEGVFMHKKAQK
LKFLCERNDK-VFFASVQSGGSSQIYFMTLGQNVLFNW----

MARECA-ARSLDG---IDLAALRDPAGI

PF00069 // ENSGT00920000148966_3_Domain_1 (29, 321)

FELVQVVGNGTYGQVYKGRHVKTGQLAAIKVM
NV----------------------------TENEEEEIKLEINMLKKYSHHRNIATYYGA
FVKKSPAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYICREVLRGLAHLHAHH
VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEENPDS
TYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKFLNFVES
CLVKNYLHRPSTETLLKHSF

ENSGT00920000148966_3_Linker_1_2 (321, 1582)

IRDMQNERQVRIMLKDHLDRTRKKKGEKEETD-YDYSGSE
EEDD-----------------------------ELNEDEGEPSSIVNLPGESTL------
-----RREFLRL-------------------------------QQENKNRSD--------
-----------------------PQ----RQQQQLKDQEKYKKQLLTERQKRI---EQQK
EQ---RRRLEDHQRREQELRRQQECDQRWTEANDVQRREERCKEDKRAVED-DERFIADG
QRKSE--------------KKQ---------------------KKVEDVQH-NKKGHRTL
PKDQTQLL----SLQHDHKQKK----------K----------EPSKSSSSA--------
-------------------------A-----------------HLPSSN----TTKE--A
E------GQRKR--SDGI------------------------------------------
---------------------------------------------QPALQWPAALGHDVM
PQAKVGSGSSSSP-CTPALQRAVLVQCDNFQASKDVYHS----SS-LS--DM--------
-----------------------V------T---------TLVS---LGQDDVFWS--G-
NQSEEQPPKVPERTTSKFYSRDQ-PG---------------------------QQRCH--
---------------------S-----------------------SNSHQ----------
------LSPGGHALKLN---SSS-------SSTAGNKPWEMASHQNSRSTSG-NPGPAKG
ENALSQNHIQLHKK---PEKVS--------------------------------------
--------------HLGQMASPCSFAKGKDSANLFLKAADYSSSSDEVS-----------
-------------SSDEDDTNHTRQLLSSRVADFSRTRV-----PDGIELK---------
-------PQSTIAEQKDQVLGKQISSTQEGLWNINNQNYL-----LPDLLQQSQ-ISNAA
VNPPKVPLTNQEPQNKSLSKTPSTESTPSKSST---SSTTSFTSFIDP------------
--RLLPI-------TPPTSPVGP-PCSS------PSSAKPEPVRRENARKGSVVNVNPTN
IRPQSDSPEIRKYKKKFNSEV

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

ICAALW---GVNLLVGTENGLWLLDRSGQGRVYSLITRR
RFQQMDV-LEGLNVLITISGKKNKLRVYYLSWLRNKILRNDPEVEKRQG--------WVS
VGDLEGCVHYKVV-KYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK-------------
------------------------------------SF--TSLHHKPLSVDLTVENGQRL
KVIYGSLVGFHAIDVDSGSVYDLYLPTHIQGAIRPHAI-IILPNTSGMELLLAYEDEGIY
IDIYGHFT-KETVLQWGEMPASVAYLQSNQVMGWGEKAIEIRSVETGHLDGVFMHKKAQK
LKFLCERNDK-VFFASVQSGGSSQIYFMTLGQNVLFNW----

------------------------------------------------------------
---------------------L

PF00069 // ENSGT00920000148966_3_Domain_1 (83, 321)

RALMSILIPQDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYVCREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVINCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHAF

ENSGT00920000148966_3_Linker_1_2 (321, 1578)

VEDIKNERHIVESFKKHLTGIIKKRQKKECYLQE------
----K------SRLYG--------------RCKY--------------------------
--------SC-------------------------------P-----KHFDIGNPKMQVK
APPRLRRAAQVLTPLQAQVKAPRPIQVQA---QVLKEQQDQVQAPVSEQPQDL---DQVP
EEFQGQDQVPEQQQRQGQARELQQGQQQVPEQQLEQ---N---EQQEVQEQAVEPVQE--
ETEAQEP-ESLQI------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTGESAQAQAWALEPPQ-------------
------------------------------------------------------------
----PEQARK-KKSKVSSLRQALAKRLSPKRFRGKSSQRPEENPLISFPEVDRTLIELQ-
VNVYKS-NI-----LLRTPTC-SPPNESALPVSPFVTV--L--PASNSLYPPIPPPDR--
---AVIDC--GR---APTSS---------SGLR----MIN--------------EVTTEG
HPSGN-PRS-VRP-------------DTNSP-VNV-------KQR-SSPNAQNFPAASGD
SN-HKVSTVKHRANVYSPRAVMSSTEREMGITSS-NTIPGDLGENAFLQKKSKWQKYSSA
KPDRHSHWILATGYEK----NTGGL--------------------NC-TVKYNDDDNSD-
---------------------EAVAEEDSYHDDGP--SWPSSIYILVEYTLE--------
-------------------KLPKDKPTKKSIRNSFVNSSYGKGGSCKQDGRDGSD-----
--------RRGGTY----------RGNGSHKTSRSQGESAAIGDRGR-------------
-RGGKEGSGGKGVSGANEDFEHQQELL-----TLDGNYYVSIVIKARPYHPPTWPYEN--
-----------------PHFGH------------CR---FGPDLQQ-LHVLQVPSGGSEA
SNIIASVAAPP---------APDNDMP---------------------------------
---------------------------SVCLI--WSYGGLVEVPEEPPKQPSDINVNPLY
ASSACKKPLIHMYEKEF

PF00780 // ENSGT00920000148966_3_Domain_2 (1578, 1936)

TSEICCGSLWVQTGVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNDDPESKKRQEEMLKTEEACKA
INKLTGCEHFSVL-QHEETTYIAIALKSSIHLYVWAPKSFDESTAIK-------------
------------------------------------VF--PTVGRKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
IEANEQLF-KKILEVWKDIPSSVAYECTQRTTGWGQKAIEVRSLQSRVLENELKRRSIKK
LRFLCTRGDK-LFFTSTLRNHHSRVYFMTLGKLEELQSNY--

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1582)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVQEQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------GQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDRSR--
--------GKEEAY----------RGYGRDRANRSHGGSAANEDNAAIGDQEEHAANIGS
ERKGSGGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDISES-STQSDFSANHSS------------
----------------PSKGFGRSAAANFASP--ILYAGFVEVPEESPKQTSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEI

PF00780 // ENSGT00920000148966_3_Domain_2 (1582, 1927)

CCGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VQEIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQVQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQV--QAQVS-KKQQAQTQ---ISEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNHQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAVSEDNAATGDQEEHAANIGS
ERKGSEGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-SIQSDFSANHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVELPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEDLQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRIELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRANGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRNIKNEGHVVESLKKHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVKALQ
HLQGAARVFMPLQAQDSAPRPLQGQAQAHQRLQGA-ARVFMPLQAQVKAKASRPLQMQMK
APPRPRRTAWMLMPLQAQVKAPRPLQV--LAQIP-REQQAQTQPQASEGPQDL---DQVP
EEFRGHDQVPEQQQRQGRVPEQQQRQNQVPEQQLEQ---NGIPEQPEVQEQAAEPTQA--
ETEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTEGSLQAQAWALEPTQAVGSV--------
QALIEGL-----------SRDLLQAPNSHNS--KPLGPLQTLMENLSSD----------M
FYSQPEQARK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEEFELSDLEAHRQR-RQRRW
EDIFSPHEE-----DLRQVAN-DKEDESSDNDEVFHSIQAE--VQIEPLQPYIPNPKE--
---NEVQEISAS---VPYNQDR------VHHVK----FSS--------------------
--IVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNPQNCPAASES
S-SEEQSPVTRRRSQSSPPYSTIDQKLLIDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPEPVIQ----PPEED--------------------GDYVELYDAGADTDD
DDD-----------------DSNDAYEDTYDRDNGSDDLDNQVDQAHSVGEDHDVENND-
-----------------DVIDDKG--NNPDDAPSWPRPGYGRGGSC---KQDGKYGSY--
--------RREGTF----------NNYGSQGASRIHRESAASGDSADIGDYEGHRASIGS
GRRGKEGNGNDGISGTNEESKAL---------ELNGQENSS-------------ETDD--
-----------------PVL-E------------RP---ASQ--EF-EHQPEGSGLRREA
SNAVASGAAPI---------APDDENN-SVDISEV-SAESGFSATHSS------------
----------------PSNGSERAANADFAGA--ILYAGFVEVPEKSPKRPSEVNVNPLY
VSPECKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIKRR
PFRQIQV-VEPLNLLITISGRKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAYECSQRTTGWGQKAVEVRSLQSRALESELKRRSIKK
LRFLCTRGDK-LFFTSILRNHHSRVYFMTLGKLEELQSTYSV

----MAGPGGWRDKEVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLYLGEKSGHWTRILSN
NISFLVLQTPLPEIGRRVRVNKYQKSVGWRYS

PF00069 // ENSGT00920000148966_3_Domain_0 (93, 171)

DEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREIL

ENSGT00920000148966_3_Linker_0_1 (171, 202)

EVSLHIVILP
----------------NLERT

PF00069 // ENSGT00920000148966_3_Domain_1 (202, 321)

LDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLVRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VRDIKNERHVVESLTKHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDNAPRPLQGQAQAPQRLQGA-ARVFMPLQAQVKAKASRPLQMQIK
APPRLRRAARVLMPLQGG-RTPRTLQA--QAQVP-KQQQAQAQAQASEQPEDL---DQVP
EEFQGQDQVPEQYQRQGQVPEQ-QRQNQVPEQQLEQ---NAAPEQPEVQEEAAEQEQA--
ETEAEEP-ESLRV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVER--QTEGSPRAQAWALEHPQAVSSV--------
QALIEGL-----------SRDLLRAPNSHNS--KPLGPLQILMENLASD----------V
FYSQPEQARK-KKSRVSSLRQALAKRLSPKRFRAKSSRRPEELELSDLEAGRQR-RQRRW
EDTFNQHEE-----ELRQVEN-DKEDESSDNDEVFHSVQAE--VQIEPLQPYVPNPKG--
---DEVQDR-PS---MPYNQDH------AHGVK----LSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SSRNPENCPAASES
S-SEEESPVTRRRFQSSPPYSTIDQKLLIDIHVPNGCKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIR----PPEED--------------------GDYVELYDAGADTDG
DNND----------------DTHDAYEDNYDLANGSDDLDNQVYQANAVCKDYDDDDNN-
-----------------DD-SADDTDNNRDDVPSWPRASYGRDGRWKQDSSDGSNGKEVY
----RVY--------------------KNHKANRSYGGSAATGGSATIGDQEGHEAGIGS
GRRSSRGNGGKGVTGTNEESGAL---------ELNRRENCS-------------ETAR--
-----------------PGL-E------------RL---ASW--DF-EHQQEESGGRSEA
SS--------A---------ALDDGND-NKDILEL-STQSDFSAFHSS------------
----------------PSKGSGRVTDADFASA--ILCSGFEELPEESPKQPSEVNVNPIY
VSTECKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKANITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLSWLKNKILNNDPESKRRQEEMLKTEEAYKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVICIDQSADSEGD
YMSYEAYVRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLSIGSEKRL
KVFFSSADGYHIIDAESEVISDVTLPNNPLEIIIPQNI-IILPDCLGIGMMLTFNAEALS
VEENEQLF-KKILEVWRDIPSSVALECTQRTTGWGQKAIEVRSPQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEEFQSNDGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF07714 // ENSGT00920000148966_3_Domain_1 (30, 316)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTALPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLKKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPKVKSSGWSRKFHNFMEK
CMIKNFLFRPTSANM

ENSGT00920000148966_3_Linker_1_2 (316, 1583)

LHHPFVRNIKNEGHVVESLKKHLIGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
HLQGAARVFMPLQAQDNAPRPLQGQAQAPQRLQGA-ARVFMPLQAQVKAKTSRPLQMQIK
APPRLRRAAWMLMPLQAQVKASRSLQV--QVQVP-KEQQAQAQSQTSEEPQDL---DQVP
EEFQGQDQIPEQQQRQGQAPEQQQRQNQVPEQQLEQ---NQLPEQPEVQQQAPEPTQA--
ETESEEP-ESLQV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QNEGSPQAQAWALESPQAVGSV--------
QELIEGL-----------SRGLLRAPNSHNS--KPLGPLQTLMENLSSN----------T
FYSQPEQARK-KKSKVSSLRQALAKRLSPKRFRAKLSRRPEEFELSDLEACRRR-HQNRW
EDIFNQHEE-----ELRQAAN-DKEDESSDNDEVFHSIQAE--VQIEPLQPYVPNPKG--
---NEVQERSTS---KTYNQDC------EHRVK----ISS--------------------
--NVP-QQS-VLE-------------QSQKP-IDI-------RQR-SSQNLQNCPAASDS
--SEEESPVTWRRSQSSPPYSTIDQKLLVDVHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDTGA---D
TDGDD-AD-------------SNDVYEDTYDHDNGNADLDSKVDPANDVGEDYEDNDND-
-----------------GTIDDKANNHDD--APCWPRTSYDRDGSC---KQDGRDGSD--
--------GGEETC----------CSYGSQRVSTGHGENVASGGSVAIRDHEELGANIGN
GRRVKEVNGGKGISGTKEESGAL---------EFSGGENLS-------------ETDS--
-----------------QGL-E------------RP---TSH--DF-EHQQEEPGGRSEA
SNAIASGAALA---------APDDENN-SMDISEA-STQSGFSVSHSS------------
-----------------SNGSGKAANADFASA--ILYAGLVEAPEKPPKRPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIY

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1926)

CGSLW---GVNLLLGTRSNLYLMDRSGKADIIKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLTWLRNKILNDDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTAGHKPVTVDLAIGTEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDSLGIGMMLTFNAEALS
MEANEQLF-KKILEVWKDIPSSVAVECTQRTTGWGQRAIEVRSLQSRVLESELKRRSIKK
LRFLCIRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAAPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMEFCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAYR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFQNFMEK
CMVKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VQDIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFERKE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLMGQAQASLRLQRA-ARVFMPLQVQVKSKVSRPLQMQIK
APPRLQRAARVLMPLQAQGRTPRLLQV--QAQVP-KKQQTQTK---ASEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQAPEQQQRHNQVPEQELEQ---NQAPEQPEVQEQAADPAQA--
EAEAEEP-ESLRV------HAQLFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPVEG--QTEGLPQAQAWTLETPQATDSV--------
QALIEGL-----------SRDLLRAPNSNNS--KPLGPLQTLMENLSLN----------R
FYSQPEQAWK-KKSKVSSLRQALAKKLSPKRFRAKSSRRPEELELSDLEARRQR-RQHRW
EDVFNQHEE-----ELRQVDK-DNEDESSDNDEVFHSIQAE--VQIEPLQPCISNPKI--
---IEVQERSPS---VPNNQDH------ANHVK----FSS--------------------
--GVP-QPC-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWPAASES
S-SDEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPISQ----PHEED--------------------GDYVELYDVGADTDG
DDED----------------ESNDAYEDTYDHANGNDGSDNQVDQANNVYEDHDDDNNK-
-----------------SVDD---VNDNYHEAPRCPRASYGRDGSC---KPDGYDESN--
--------GKEEAY----------GGYGSHRVNSNHEGSAASEDNAATADQEEHAANISS
ERRDSGGDGGKGVIRTSEESGAL---------GLNGKENCS-------------ETDG--
-----------------PVL-K------------RP---ASQ--NF-EYLQEEPGGGNEA
SNAIDSGAAPS---------APEDEND-NKDISES-STQSDFSASHSS------------
----------------PSKGSGRSTDADFASA--ILYAGFVEVPEESPKQPSEVNVNPLY
VSPACKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLCLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLGHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEIWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSKVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYSV

----MAGPGGWRDREVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGVFTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CTIKNFLFRPTSANMLHHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTRHLTGIIKKRQ--KKGIPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPGPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLLQI--QAQVS-KKQQAQTQ---TSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQIFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTPEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSDNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQRRW
EDIFNQHEE-----ELRQVDK-DKEDESSDNDEVFHSIQAE--VQMEPLQPHISNPKK--
---IEVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAASES
S-SEEERPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVIQ----PPEED--------------------GDYVELYDAGA---D
TDGDD-DD------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVYKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSYPRASYGRDGSC---KQDGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAATGDQEEHAANIGS
ERKGSRGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-N------------RA---VSQ--DF-EYLQEEPGGGNEA
SNAIDLGAALS---------APDDESD-NKDIPES-SIQSDFSANHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGRKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAI--------------
-----------------------------------KVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNN--------NI-IILPDCLGIGMMLTFNAEALS
VEANEQLF-KKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------IPLIFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQ
QLQGAARVFMPLQALDSAPRPLKGQAQAPQRLQGA-ARVFMPLQAQVKAKASKPLQMQIK
APPRLRRAARVLMPLQAQVRAPRLWQVQAQ--VS-KKLQTQT---QTSEPQDL---DQVP
EEFQGQDQVPEQ-QRQGQTPEQQQRHDQVPEQELEQ---NQEPEQPEVREQAAEPAQA--
ETEAEEP-ESLRV------NAQVFLP--------------------------------LL
SQDHHVLLPL----HLDTQ--VLIPVEG--QTERSPQAQAWTLEPPQAIGSV--------
QALIEGL-----------SKDLLRAPNSNNS--KPLGPLQTLMENLSSN----------R
FYSQPEQARE-KKSKVSTLRQALAKRLSPKRFRAKSSRRPEELELSDLEARRRR-RQHRW
EDIFNQHEE-----ELRQVDKNST--------EVLHCV----------------------
---FKVQERSPS---VPNNQDH------AHHVE----FSS--------------------
--SVL-QRS-LLE-------------QAQKP-IDI-------RQR-SSQNRQNWLAVSGD
SKHKISRPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVY--LTNEWVGYNAL
SEIFRNDWLTPAPVVQ----PPEED--------------------GDYVELYDAGADTDG
DDDD----------------ESNDTYEDTYDHTNGNDDLDNQVDQANDVCKDHDDDNNK-
-----------------SVDD---VNNSYYEAPSCPRASYGRDGSCKQ---DGYDGSR--
--------GKEEAY----------RGYGSHRANRSHGGSAASEDNAAIGDQEEHAANIGS
ERKGSGGDGDKGVIRTSEESGAL---------GPNGEENCS-------------ETDG--
-----------------PGL-K------------RP---VSQ--DF-EYLQEEPGGGNEA
SNAIDSGAALS---------APDDESD-NKDISES-STQSDFSVNHSS------------
----------------PSKGFGRSADANFASA--ILYAGFVEVPEESPKQPSEVNVNPRY
VSPSCKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1873)

CGSLW---GVNLLLGTRSNLYLMDRSGKADITKLIRRR
PFRQIQV-LEPLNLLITISGHKNRLRVYHLTWLRNKILNNDPGSKRRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVMCIDQSADSEGD
YMSYQAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLDHKPVTVDLAIGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNI-----PRNY-CIPPFE-----FFQLSKER--
-------F-C-VFLIFFFFICIVAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSTLRNRHSRVYFMTLGKLEELQSNYGV

----MAGPGGWRDKEVTDLGHLPDPTGIF

PF00069 // ENSGT00920000148966_3_Domain_1 (30, 321)

SLDKTIGLGTYGRIYLGLHEKTGALTAVKVM
----NARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGA
FFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICREILQGLAHLHAHR
VIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRR
SYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEK
CMIKNFLVRPTSANMLYHPF

ENSGT00920000148966_3_Linker_1_2 (321, 1583)

VREIKNERHVVESLTKHLTGIIKKRQ--KKGIPLVFEREE
AIKEQYTM---RRFRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQIQALQ
KLQGAARVFVPLQAADKAPRPLQGQTQAPQRLHAA-ARVFMPLQAQFKAKASRPLQMQIK
APPRLRRAAQVFMPLQAQGRTPRPLQA--QTQLP-KEQQAQAQAPASEQPQDL---DQVP
EEFQGQDQVPEHHQGQGQVPQ-QQRQNQVPEQQLGQ---NPAPEQPEVQEEAAEPEQE--
ETEGEEP-ESLLV------HAQVFLP--------------------------------LL
SQNHHVLLPL----HLDTQ--VLIPIERECQIEGSPRAQIWALEQPQAIGSV--------
QALIEGL-----------SRDLLQAPNSRNS--KPLGPLQTLMENLASD----------T
FYSKPEQARK-KKSKVFSLRQALAKRLSPKRFRAKSSRRHEELELSDLEAGRQR-RQRRW
EDVFNQNEE-----VSRQVEN-DKEDESSDNDEVFHSVQAE--VQIEPLQPYVPNPRE--
---NEVQD-GPS---MPYNQDH------ANGVK----VSS--------------------
--SVP-QRS-LLE-------------QAQKP-IDI-------RQR-SFQNPQNFPAASES
S-SEEESPVTRRRSQSSPPYSTIDQKLLIDIHVPNGCKVGKISPPVY--LTNEWVGYNAL
SEIFRSDWLTPASVIQ----SPEED--------------------GDYVELYDAGADT--
-DNDD---------------DTRDAYEDTYDLANGSDDVDNQVYQANDVCKAYDDDDNN-
-----------------DDSVD-DTDNNRGDVPSWPRASYGRDGHW---KQGV-------
--------------------------YKSHKANRSHGESAATGGSAAIGDQEGHEAGIGI
GRSSSNGNGGKGVSGTNEESGAL---------ELNRRENYS-------------ETDR--
-----------------PRL-E------------RL---ASW--DF-EHQQEEPGDRSEA
SNA-----------------APADGNA-NEDILEL-SIQSDFSAFNSS------------
----------------PSKDSGRVTDTDFASA--TLCSGFEEMPEESSNQPSEVNVNPVY
VSTEYKKPLIHMYEKEFTSEIC

PF00780 // ENSGT00920000148966_3_Domain_2 (1583, 1927)

CGSLW---GVNLLLGTRSNLYLMDRSGKANITKLIKRR
PFRQIQV-VEPLNLLITISGHKNRLRVYHLSWLKNKILNNDPESKKRQEEMLKTEEACKA
IDKLTGCEHFSVL-QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVICIDQSADSEGD
YMSYEAYIRILAKIQAADPANRFKRPDELLHLLKLKVF--PTLGHKPVTVDLSVGSEKRL
KIFFSSADGYHIIDAESEVMSDVTLPNNPLEIIIPQNI-IILPDCLGIGVMLSFNAEALS
VEENEQLF-KKILEVWRDIPSSLALECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKK
LRFLCTRGDK-LFFTSILRNRHSRVYFMTLGKLEELQSSDGV