ENSGT00910000144259_0 : Linker Region Query Results

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-----VSEDERLRAMLSD--KLTVMEPPA-------------------------------
-----------------------------------PAS----DVTLGELLGNPEGQSLAG
SPS-------QEEEFK--QVTVTHWKIQTGGPAS---ACG-------ESG-RGPLLNPDL
LLLPPEL----------------------VGGGAHPC-DVCGES---FTF----------
-GSDLVRHQTSHTGEKPHTCDQCGKGFGQRALLTEHQRIHGGKRPCVCHLCGDRFAHYAD
LTE--HQRAHA-GEKPFKCAQCGKAFGHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECSECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECSECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKVHTEEKLYECR-QFE------KDLNSP--------------------------P
GFQHS------PD-----------------------------------------------
AQQEGLPVSTAPLCLGERPVGQEDPPGDL-------------------------------
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----------------------------------------------------------MS
HLEQW------------E--QLQVPDPQG-------------------------------
---------------------------------------------------SNEQELPRG
AQ--------EGGGI------LKRGKEETSQCAAEAAGCEGNVACRPKRG-DGWVEGRQ-
--------------------------------DPTPLGSICR------------------
-ARD-MSGVSVGGTSNPIACPTCGKGFSRKSNLTKHQRIHTGERPFCCTQCGKRFTQSSN
LCR--HQSLHAVGEGPWCCPECGESFPGSLGLARHRRMHAAGQRSHYCH-----QCGKSF
ASRSL-----------------------------LTIHQRSHWGEGPVSFAPXXXXXXXX
XXXXXX------------------------------------------------------
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MLPPKYLSATKPKRSWAPNLCELDSDLSQEPDAAIGEAATDSEFFHQRF---RNFLYVEF
V--GPRKTLLKLRNLCLDWLQPETRTKEEIIELLVLEQYLTILPEKIKPWVRA-------
----KKPENCEKLV---TLLENYKE----MYEPEDDTSSDAHSEGSMSRKAAEAPPPHSA
CC-------------------------DR----------DWDRKGRGRDLESRARWP-YA
RSPRSRFHQRDLSLPLMEKVAFAKEREHKHRDSVMD-YETRSQDAVSYQDV-VALXXXXX
XXXXXXXXXXXXXXXXXX--XXXXXX--XXXXXXXXXXXXXXXXXXXXX------XXXXL
IVPETKKSAHRRGICEDESSHGVIMEKFIKDVSRNSKSGRAREPSDRL------------
------------QRFP--RRPDSDWKEVPFNKRES--VIQERGHEGNAFGGGGFNLNSNL
VSRKRVLERKRRYHFDTDGKGSMHGRRGGARKRPFERSEV----RKAASGSSL------S
APPVPQLQPF-DFGATPYVCDECGRSFSVISGFVEHQITHTRENLYEY---GESFLHSVA
VSE--VQKRQA-GGKRFECKECGEPFNKSAALAEHRKIHA-RDCLAGCK---DEEYEEPF
MPSPT-----------------------------FRELQKIYGKDKFYECRVCKETFLHS
SALIEHQKTHGR----DDKGSER--------------------------------GEAFK
PSPALNELQKMYGKEKMYECKVCGETFHHSASLKEHHKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYPTEKAYDFQDGGDAFRQNSDL-IEHQKIHSRKNLFEGRGYEKSVIHSVSF
PESQKSHTI-TRPPEDEE--DEKAFTVSSNPDDSR-----EAVYERNPYERSFIHSSAFP
GAHKS-HS-----KPRVI---AEATV-QSSGATEH-WKVHAGESTSERKGYERSVIHSLA
AFRPPRGRGGNELLGCD-EQQESSAYLSDPCGQPQKTLAL-ESPYAGGKNN----IFKGS
FVHGASHTVTQDSLAGEGPSGWKKDGEPSVPKSDVREHQKARAKKKNIER---RIYETSV
IHSL-RFGEPQTFHPREKFYECPECGESFVHSSDLTEHQKIHDRKKLSGSENYIRSVIR-
---SIASTDPQTSYAEEQY-----------------------------------------
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--------------------------------------------------------AEQP
VRNECKECGECFATVEDLGIHQKIYAREKFH-GGEL------QGVGLDGLD-----RKS-
------LQEGPDEPDEPEDTIYGCKDCGLGFVDRTDLQDHQKV HG--REYLTDSREYAHS
VTHTPSVSEYQKDYIGEQL YECPACGESFVHSSFLFEHQKI HEQDQFYG--HRRYDEPFM
QPLVIS--PQRPRAPQKSP--PAGTS LQCQVCGQDFIHGSVLNEHMRV HAGDSLLE--QG
QG---STDAVSPGSAPTDLQRDQ--AKDKH YECATCGESFPSQADLREHMRI HEK-DKPY
DYGATFVHTSFLTEPPKRDSPF YECKDCGKSFIHNTVLTKHQKL HLEEEEAA--------
-----AAAQEVEANVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAEPNVEAAEPNGEAE
GPEGEAAEPNGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGAGIEDPEEEGDDQEIQVEEPY YDCRECGETFTSNSAYGEHLKT HARVIIFEP
GSVYGESSHYTEHASTS------------SNDSGRA-DDKY FKCDVCGQVFTDRLSLARH
QNTHTG---------

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--------------MMSD--GVPVTETAR-------------------------------
----------------------------------ESEAGEA------------HEARLGS
PRP-------QGPGFE--QGTVTHWKIQTGETAQ---VGS-------KSG-RNSILNSNL
LILQRDF----------------------IEREAHSC-GICGKS---FLF----------
-NSDLVRHQVSHAGEKPYTRDQCGKGFGPLSHLTEHQRVCTGDRVYVCDACGKDFIHYPS
LIE--HQQSHA-GEKPFKCSQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKAFIRS
SSLIRHYQI HTEVRQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECRECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKACGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYACSHCGKGFIQRSN
FLQHQKMHTEERLHECA-EPP----------PA--------------------------P
-----------AF-----------------------------------------------
VQQEGLPLSEATLHLGERATEEVQVGD---------------------------------
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--------------------------------MNLFSFVSDS----------TIGTGKKK
--------DENSNRSMSD--KLTVMEPLT-------------------------------
-----------------------------------PKSGEVHDPRLGELLGNPEKQNLGN
SPS-------QEEG----QVTVTHWKIQTGETAQ---VCS-------KSG-RNPILNSNL
LILQREL----------------------IEGEAHPC-DICGKN---FTF----------
-NSDLVRHQIS HNGEKT YKCDQCGKVFGQSSHLTEHQRI HTGERL YVCNVCGKDFIHYAS
LIE--HQRV HT-GEKP FKCAQCGKAFGHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYE------KDFNST--------------------------Q
NFKNN------QS-----------------------------------------------
VHQEGLPLSKAPIHLGERSVGQGEHTDNL-------------------------------
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MLPPKFLSTNKPKKSWVPDLYELDSDLSKEPGIIIGEGTTDCEFCHQRF---GDFFYVEF
A--GPK-TLTKLQNLCLDWLQPEACS-EKTVELLVLEQYLTILLEKIKHWVQA-------
----KKPESCERLV---TLLENFK-----MHEPEDDSSSDVPGEDSMNRRDPESLPPRSM
YSLC-----------------------DR----------DWDRRGRSRNLEPRDHWH-HP
RLPRGRLPQQDLPLPMERALPH--------RELVEDKDEVTPQDAMSNQDD-VDLAEDRE
PQNPIQDNMENYRKLLSL---VQLAENDGHSYMTQGHSSRSKRSAYPST------SRGLK
TVSEAKKATHRRGICEDESSHGVIMEKFIKDVSRSSKAGRARDSNDRS------------
------------QRCP--RRPENVWKGLSLTKRGS--VIRERGYEANASGGVGFHLNSTL
VSKKRVTERKRRYQCDTEGQGSTHDQKGYARKRPFECGEM----RKAMSLGSL------S
SPSFTESQPV-DFTVMPYVCDECGRCFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKRQA-GGKCFECKECGETFSKSTTLAEHREIHA-REHLANCK---DEEYEEPF
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNFSCQRER----------------------------------REIFK
PSTSLHELQKMYGKEKLYECQVCAEAFHHSASLKEHQKIHIRGKSFENKGKVCEKTFIPG
QK--RHQKTFSRDKFYGFKDDGNAFMPSSNL-SEHLKILSRKNLYEGRSYEKSVIRNLPF
TESQKSHTI-TRPPEHEE--EEKAFTISSNPDESQKFPMKEKIYERKPYERSVIHSLAFA
EAQKS-HSAGSPSRPKAM---AESTI-QSADVAEH-QKVYAGENPSERKTSERSVIHSLG
IFKWPKNRNGNEFVEHH-EKGESSIYVSDFNDKQQKT-LR-ESPNEGSKSN----NYKGS
VIHSVSHVKSQKTLAGEGSSEFKTDGELPVSISNICEHQKARAKKKNIEC---KNYEISV
IQSL-CFGELGAIHPREKFYKCQVCGESFVHSTDLTEHQKIHDRRKPSGMKNYERSVIC-
---SLASTSLQTNYTETQAQC---------------------------------------
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--------------------------------------------------------AKVQ
ARSKCRECGECFATIRDLGAHQKIYAQEKVH-RKKLFGDAVNRGTCYDGRKSLSKNSTT-
-----GGVVEDEEEEAADDSVYSCKDCGLSFADQADLNDHQNVQ---RHYLINTCKYKQS
VIHTNSISEYQQDSI-EQLYECPXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX
XXXXXX--XXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX---RGKVFVQGLPFTCFQGSQ--T-ERQYEC-TCGELILSPFRPEGHLRVHER-DELY
DYGSPFVYTSFLTEPPKRVLPFYECKDCCKSFIHI-VLTKHQKLHKEQ------------
---------DVKTDMLLPRVDLQIRGS---------------VEIAEQEVKADKPNGEAE
GLDGEAAEPNREAEQPG---GKVEQPRGD----ANEPDGAGIEDPEKRAEE-------PE
EDVDEPDSAGIEDPEEEDEDEEIEIEEPSYDCRECGETFTDNSAHREHLTARARVIVCEA
GSTYGESSCYAASAVST--------------STGTG-DNKHFNCDVCGQLFGDHLSLARH
QNTHIG---------

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-------------------------------------ICS-------QSG-RRWSQSSEL
GVPEQLH----------------------DGEKPHKC-SECGKG---FTW----------
-RSELIMHQRT HTGERP YECGECGKRFSQSSNLIKHQRI HTGERL YECGECGKRFSQSSN
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----------------------------------LIKHQRIHTGERPYECSKCGKRFQTS
SHLLQHYWVHTEERPF----------------------------------CCADCGKGFR
DNSTLIQHRRI HTGERP YECGECGKSFSRSS-----------------------------
-SLIMHQRTHTAERPYECSECGKGFQTSSHL-LQHYPVHTEER-----------------
------------PFRCPD--CGKGFK----------------------------------
---------------------------HNSTLIRH-RHI HTGERP YECGECGKRFSQSSN
LTKHQRRH----------------------------------------------------
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--E-------CGKSFRWSSDLIRHQRT HTGERPY---ECG-------ECG-KSFSRSSDL
IVHQRT H----------------------TGERP YEC-GECGKS---FSR----------
-RSHLIMHQRI HTGEKP YECGECGKSFSRSSTLIKHQGIHTGERPYECSECGKRFQTSSC
LLL--HYPVHK-EERPFCCPDCGKGFRENSTLIRHRRI HT-GERP YECP-----RCGKRF
SHSSN-----------------------------LTKHQRRH------------------
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---------------MSD--TLTIMEHPT-------------------------------
-----------------------------------SESREVREARLGQLLGNPEGQNLGS
PSS-------QEDGFK--QVTVTHWKIQTAETAQ---I----------------------
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--------------------------------------------------SHTDFIHYTN
LAE--HQQVHM-GEKPFRCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLVEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSFCGKGFIQRSN
FLQHQKMHTEEKLYECS-QLG------EGCTPP--------------------------P
DF----------------------------------------------------------
IDQEALSLNETPTCLSE-LTGQEGHMGNL-------------------------------
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--------------MRGQEFNDFGKNFRMTSNSVRIQRDPSGGRLQQWVEMGQRFKQNSD
LNN--YQKDYA-KEKSCDNSVYWKQFGQSSNLIEHQKIHS-REETYECN-----EYGKHF
IRRSL-----------------------------LIQHQGIHTGAKTYKCSECGNTYSKK
SLLNDHQKIHNAGKHY----------------------------------QCNVCGKAYN
KKSTFVDHQKI HTGEKP YECSECHKCFIRKSLLIRHQRI HTGEKP YEC--TECGKACSQK
SALLDHQRLHTGEKPYECSECE--------------------------------------
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-----------------------------MHQPEDDNSDVT-SDDEMTRNRGESPPPRSA
YSFSGDR--------------------------------DWDRRGRSRDREPRGRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDTDSR--A-DESRSQDAESYQNM-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSNRS------------
------------QRFP--RVSDDNWKDLSLNKRES--VIQERVYEGNSFRG-GFRFNSTL
VSRKRILERKRRYHFDTDGKGSTHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPV-DFGAMPYVCDECGRSFSVISGFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQI-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---DQEYEEAF
MPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDGKDNDRER--E----------------------RERERGEAFM
PSSNLNEFQKMYGKEKIYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKMCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNIFEGRGYEKSVIHSMPF
TESQKSHTI-TRPPESDE--DEKPFTISSNPYENQKSPTKENGCEGQSYERSVIHSLASV
EAQKS-HSVAGPSKPNVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
VSKPPKSRNGNELVESN-ENGESSIYISDLTGKRPKIPAR-ENPCEGSSKN-YNYNYEDS
VIRSVSHAKPQKGVPGKGSGEFKKDGEFSVPSSNVREYQKARSKKKYIEHR---SNETSV
IHSL-PFGKQQTLRPRGMLYECQECGECFAHRSDLTEHQKIHDREKPSGSRNYEWSVIH-
---SLAPTDPQTSYAQEQY----AKEQARNKC-KFSQSFGTSKDLNTHQKIYDQE-----
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-------------------------------------KSHGKKSQGK-------------
KN---------------------------------HR-----------------------
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-------EETHG-----------------KKSH---------------------------
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-------------------------G----------------------------------
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--------------------EKS-------------------------------------
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---------------NGEKIQREETHGEETH-GQEIIEDPVIQGSDM-------------
---------EEPQKDDPNDTIYECEECGLGFVDLTDLTDHQKV HR--RKCLVDSREYTHS
VSHTHSISEYQRNYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--LKGCDDGFI
ALLPV--KPRRNRAAERNP-ALSGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERPFECAVCGESFVNAAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAMPFYECKDCGKSFIHSTVLTKHKEL HLEDDD-----DDDND
DEAAGAAAQEVEANVHVPQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGGAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPE-ESEDQEIEVEEP YYDCHECTETFTSSAAFGEHLKT HASMIIFEP
ANAFGECSGYIEPAST------------STGGADQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

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-----VSGRGNLQKAVSE--ALPVMELTA-------------------------------
-----------------------------------PTSGRGPDPRLGRLLGNLDAQSLRS
CTS-------QEGGFQ--QVTVTHWKIQTAEAAQ---AGS-------KSE-GSPLLSPDL
LLLQREL----------------------IEGEAPQH-EACG-S---FPF----------
-NPVLARHQASHAGEKAHRCDECGKGFSQSSHLVEHQHAHGGERLYVCNACGKDFVLYTD
LLE--HQKVHT-GERPFKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKAFIRS
SSLIRHFQV HTEVRQY----------------------------------ECQDCGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHSG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------KEFTPP--------------------------P
DFKSS------QE-----------------------------------------------
APQEGLPLSQTAVHFGETVMDGQGCHLSL-------------------------------
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MLPPKSLSATKPKKSWALNLYELDSDLS-EPDSVPGEGATDSEFFHQRF---RNFLYVDF
I--GPRKTLLKLRNLCLDWLQPETRTKEEIIEILVLEQYLAILPERIKPWVCA-------
----QKPETCEKLV---ALLEQYEE----MYEPEDDNSSDTHSEGGMSRRAAESPPPRPA
LPCCSRAR------------------------------ERERRRGRSRDMESRDRWP-SV
RSPRSRFHQRDLALPLAER---AKEREHRRRDSLLD-LDARSEEAVLYQDM-VALTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGNSHMTQGHSARSKRSAYPST------SRGLK
TAPETKKSAHRRGICEAESSHGVIMEKFIKDVARSSRSGRVREPSERP------------
------------HRLS--RRAGGDWKEASFSRREA--GASERGPEGGAFGGGGFSCSSDP
VSKKRALERKRRYHFDVEGQGPVHDPRGGARKRPFESGGEARRGAKAAGASSL------S
APPVALSQPL-DVAAMPYVCDECGRSFAVISEFVEHQIVHTRESLYEY---GESFIHGAA
VSE--AQGRPA-GARRPEGA-------QAAGNS-HRRGQA-REHVGGSG---DEEQDEPF
LPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALVEHQKVHNH----EDREKERS-------------------------------TGAVR
RTPMLGELQRACGKEKRYECKVCGEAFHHSAALREHQKIHGRGSSADGRARAFEEAFAPG
PSLKRRQKTYSREKLCDFREGGDAFGRSSDF-MEHQRIHSRKSYFDSRGYEKPLLHSMPM
PSSQKSHTI-TRPPEDED--EEKAFTASSNPEDGQEAR----------------------
--------------------------------------------AYERSTYERAIFHSLA
AFRPPRSL--------R-EDGEPSTYLSGLRDPPQKPPAW-ESPYAGGRHS----FFRSS
VFYRASRPAPLDHLAGEGPSGWKRDGEASSPSSDGHQHQKARAKKKNIER---KNYDASM
IPTL-RFGEPQTFRPRERFYECPECGEFFVRSSELAEHQKIHNRKKLSGSKSYLRSALR-
---SLSSTDPQTSYQGQSVQIGYAQEAAQTSYAELAAQTSY--AELAAQTSYAEEPAQTS
YTEAPAEGSY--------------------------------------------------
----TEEPAQTSCIEEPAQTSCIEEPAQTSYTDPAAETSYSEEPAQTNYTEAPAETSYTE
EPVQTSCIEEPAQTSNTDPAAETSYTEEPAQTNYTEGPAEASCTEEPSQTNYTEGPAETS
CTQEPAQTSCIQEPAQ--TNYTDPAADTSYTEEPAQTNYTEESAEASYTEEPAQTSCIEE
AAQTSYK--PAQTNYTKEPAEASYTEAPAQTSCIEEPAQTNYTEESAEASYTEEPK-PAQ
TSYTDPAAETNYTKEPAQTNYTEESAEASDTEEPAQTSCIEEPAQTSYTDPAAETSYTEE
PAETSYTEEPAETSYTEEPAQASYTEEPAQASYTEEPAQTSCSEEPAQTSCSEEPAQTSY
AEEPAQTGCSEEPAQTSYSEEPAQTSYAEEPAEASYAKKPAQTRYDEEPSQTSYSEEPAQ
TSYAEEPAQTSYAKEPAQTSYAEKPAQTRYDEEPSQTSYSEEPAQTSYAEEPAQTSYAEE
PAQIRYAEEPDQTSYAEEPDQTSYVEEPDQTSYVEEPDQTSYSEEPDQTSYTEEPDQTSY
SEEPAQTTYAEEPAQTSYSEEPAQTSYSEEPAQTTYAEEPAQTTYAEEPAQTRYAEEPAQ
TTYAEE-----------PAQTRY---------AEEPAQ---------TTY----------
-----------AEEP--AQTR-YAEEPPAETSYAELVAQISYAELAAPTSYAELAAETSY
FEPPTQTSYTEPAETNYAEPAAQVSFDEPPAEASYADLAAEISYAELAAETSYADLAAHI
SYDEPPAETSYAELAAQISYSEPAVQTSYAELAAETSYSEPLAQTSYAELTSETSYCEQP
VLNECKECGECFATVEDLGSHQKIYAREKFH-DGKLFGEPVMQDLGLDGSPEE-------
------ELEEQEEPEEPEDSIYGCKDCGLGFADRADLRDHQKVHG--RRCLVDCREYTHP
AVHMPPVSEYQKGCRGEQLYECPACGESFVHSSFLFEHQKVHEQD---------------
-----H--PRRPQAPPKSA--PAGVGPQCQVCGQEFIHASGLSEHARGHAGEGLPD--QG
QG---GTGAAGPGPAPTEPQQDP--GEEPRYECETCGESFPSQADLQEHMRV HEK-GEPY
DYGAAFVHTSFLTEPPKRDWPF YECKDCGKSFIHSTILTKHQKLHLQEGGAAA-------
------AAQEAEARVLVPREVLRIRGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPLGEAE
GPEWEAAEPSGEAEQPH---AEAEQPDMD----ADEPDGAGIEDPEERAEE-------PE
GDDDEPDGAGIEDPEEEGEEQEIQVEEPYYDCGECGETFPSGAAYAEHLTAHASLVILEP
AGLYGEGAG--------------------DPEGGQP-DAELFKCDVCGQLFSDLLSLARH
QNSHTG---------

TLPPKHLSATTPKKSWAPNLYELDSDLTKEPDVVIGEGPTDSQFFHQRF---RNIIYVEF
V--GPRKTLVKLRNLCLDWLQPETRTKET-IEPLVLEQCLTIIPEKLKPWVRA-------
----KKPENCEKLI---TLLEYYKE----MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
RSFS-DR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGECSIYISDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFGRISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDLNTYQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKESQGE-------------
KI---------------------------------RG-----------------------
------------------------------------------------------------
-------AA---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-AAAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEPYYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------VFN----------TRRTGEKK
VTEAWISEDENSHRTTSD--KLTVMELPS-------------------------------
-----------------------------------PESEEVHEPRLGELLGNPEGQSLGS
SPS-------RDRGCR--QVTVTHWKIQTGETAQ---VCT-------KSG-RNRILNSDL
LLLQREL----------------------IEGEANPC-DICDKT---FTF----------
-NSDLVRHRIS HAGEKP YTCDHCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIHYAG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYERS-QYG------RDFNST--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKAPIHLGERSVDKGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---------------

MLPPKYLSATKPKKSWAPDVHELDSDLTKEPDATIREGATDPEFFHQRF---RNFLYVEF
V--GPRKTLFKLRNLCLDWLQPETRTKEEIIELLVLEQYLTILPEKIKPWVRA-------
----KKPENCEKLV---TLLENYKE----MYEPGDDNNSDLRSEDSMSRKGAESPPPRSA
SSFCSDRDRDWDQEWDRERDRDWDLDWDR----------DRERRGRSRDLGSRDRWP-YP
RNPRGRLPQRDLSLPLMEKTTFATERERKRRDSVMD-YESRSQDAVSYQDV-VNLTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPST------SRGLK
SMPETKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESNDRS------------
------------QRFP--RRPDSDWKEVSFNKRES--VIQERGYEGNGFGG-GFNFNSSL
VSKKRVLERKRRYQFDTDGKGSAHEQKGYARKRPFECSEM----RKAMSMSSL------S
APSFTESQPL-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQA-GGKRFECKECGETFNKSAALAEHRKIHA-REHLAECN---DEEYEEPF
MPSPT-----------------------------FSELQKIYGKDKFYECKVCKETFLHS
SALIDHQKIHGR----DDKDNER--------------------------------GEGFK
PSPPPNDLPKTYGKEKMYECKVCGETFHHSSSLKEHQKIHTRGNLFESKGKVCEETFIPG
QSLKRRQKTYPKEKLYDFTDGGDAFRQSSDL-SEHQKIHSRKNLFEGRGYEKSVIHSVPF
TESQKSHTI-TRPPEDDE--DQKAFTVSSNPDDNQKVPPQENVYERKPYERSVIHSLAFA
KAEKS-HSAVGPSKPKVI---AESTI-QSSGVTEH-QKAHAGENTSEGKKYERSVIHSVA
AFKPPKSCNGNEVVECE-EKGESSTSVSDRHDKQQKTPAR-ENPNEGGKNN----NYKDS
VIQSVSHMESQKSPTSQGSSELKKDGESSTPTSNVREHQKARSKKKNIER---RNYETSV
IHSL-RFGDHQTFRPREKFYECPECGESFVRSYDLTEHLKIHDRKKPSGSKNYERSVIR-
---SLVSTDPQTSYAEQQPQTSYAGHSS--------------------------------
------------------------------------------------------------
---------------------------Q--------------------------------
----------------------MRYSDQA-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------AQTSYAKHPVQTSYS--------------------------------------
GMH---------------------------------------------------------
------MSYAVQPGHMSYTQQAAQTSYMVQPTQIS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------YDEEQAQTSYAEQQ
VRNRCRECGECFATIGDLGAHQKIYAREEFH-GRKLFGDTVIQGIGLEGPR-----PEEP
RQNEPDEQD---EQDEPEDAIYGCKDCGLGFADRADLKDHQKV HG--REYLIDSREYTHS
VIHTHSVSEYQKDYIGEQL YECPACGESFVHSSFLFEHQKIHEQDQFYG--QRRYDEPFV
QPLVIN--PRRPRAPQKNP--TAGTSLQCHVCGQDFIHGSVLGEHMRIHTREDLPE--QG
QR---SEDAVSPGLALTEFQRSQ--TEEKHYECKTCGETFLNQSDLREHMRI HEK-DEPY
DYGASFVHTSFLTEPPKRDSPF YECKDCGKSFIHNTVLTKHQKL HLEEEEE---------
-----EGAQEVEANVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAEPNVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGAGIEDPEEEGEDQEIQVEEP YYDCRECGETFASNSAYGEHLKT HARVIIFEP
GNVYGESSRYTEHASTS------------TSDNDRA-DDKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--ELTVLEPSA-------------------------------
-----------------------------------SESREFHEDRLAQLLGNPDKQSLES
PSS-------QDGGFT--QMTVTHWKIQTGDTAQ---TCS-------KSG-RNPILNSNL
LILQREL----------------------IDAEARSC-GGGGKG---FPF----------
-NSDVVPHQISHTGEKPYKCDHCGKGFSQTSLLTEHQRVHTGDGLYVCHVCGKDFVHYAS
LRE--HQHVHT-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECQECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHSGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKMHTEEKLYTYS-QLG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSVHLGERSTDRECCGNNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

MLPPKHLSATTPKKSWAPNLYELNSDLTKEPDVIIGEEVSEPN-------------LCGI
A--GPRKTLVKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRA-------
----KTPENCEKLV---TLLENCKE----MYQPEDDNSSDVASDDDMARNRGESSPPHSV
HSFS-DR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRLPPRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEVRK---AVSMSNLS---SLS
SPSFTESQPV-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKVH----FGDDKDNER----E----------------------RERERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESAI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGDFSIYVSDLSDKRQKIPAR-ENPCEGGSKN-H--NYEDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDPNTHQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGEESEGE-------------
KT---------------------------------RG-----------------------
------------------------------------------------------------
-------EETH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GEETYSEETH-GKETMEDPVIQGSDM-------------
---------EDPQKDDSDDTIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEER LFECAVCGESFVNPAELAD-HV TVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEDDDDDEA-AA-
---AAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EAEDQEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNSSDVTSDDDMARNRGESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRLPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEVRK---AVSMSNLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKVH----FGDDKDNER----E----------------------RERERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
RSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKCHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESAI-QSFDAINH-QRVRAGGNTSEGREYSRSVIYSLV
TSKPPRSHSGNELVESN-EKGEFSIYVLDLNDKRQKIPAR-ENPCEGGSKN-H--NYEDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLSPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDLNTHQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSRGEESQGE-------------
KT---------------------------------RG-----------------------
------------------------------------------------------------
-------EETH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GEETYSEETH-GKGTIEDPVIEGSDM-------------
---------EDPQKDDPDDTIYECEHCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERL FECAVCGESFVNPAELAD-HVSV HK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEDDDDDEA-AA-
---AAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

MLPPKYLSATKPKKSWAPHLYELDSDLTKEPDAIIREGTTDSEFFHQRF---RNFFYVEF
V--GPRKTLIKLRNLCLDWLQPETRTKEEIVEILVLEQYLTILPEKIKPWVRA-------
----KKPENCEKLV---TLLENYTE----MYEPEDDDNSDVHSEDSMTRKVAESPPPRSV
YSYGTERG--------------------------------RGLRARRRDLEPRDRWP-YT
RNPRGRLPQRDLSLPLMEKTTFITEREHKRRDSVME-YESRSQDAVSYQDV-VDLTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRNAYPST------SRGLK
TMPETKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESNDRS------------
------------QRFP--RRPDNGWKEVSFNKRES--VIQERGYEGNAFGG-GFNFNSHL
VSRKRVLERKRRYHFDTDGQGSIHDQKGYPRKRPFECNDM----RKAMSMSSL------S
SPSFTESQPL-DFGAMPYVCDECGRPFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQA-GGKRFECKECGETFNKSAALAEHRKIHA-REYFSECK---DEEYEEPF
MPSPT-----------------------------FSELQKIYGKDKFYECKVCKETFLHS
SALIDHQKIHGR----NDKDNDR--------------------------------GEAFK
LSPTLSELQKMYGKEKMYECKVCGETFRHSSSLKEHQKIHTRGNLFEKKGKVCEETFIPG
QSLKRRQKTYSKEKFYDFKDGGDAFRKSSDL-NVHQKIHSRKHLYEGRGYEKSVFHGLSF
TESQKSHTI-TRPPENEE--DEKAFTISSNPDDNQTFPIKDNVSEGKPYERSVIHSLASA
EAQKS-HSAAGPNKLKVI---AESVI-QSSNVTEH-QKVYAGENTSDRKKYERSVIHSLA
TFRPPKSCDGNELIECN-EKAESSIYVSDLHDKQQKTPAR-QNPYEGDKNN----SYKDS
VIHSMSHTKPQKSLTGEESSEFKKDGESSVVNSNVREHQKARAKKKNIER---RNYETSV
IHSL-SFGENQTFRPREKFYECPVCGESFVRNSDLTEHQKIHDRKKPSGSKNYERSVIR-
---SLASTDPQTSYAEQPA-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------QT
MRKKCKECGQSFATTEELRAHQKIYAREEFH-GGNLFGGSVIQGVGLDGPQ-----QGEP
QQDKPDEQDELDEQDESEDTIYGCKDCGLGFADRADLKDHQKVHG--REYLIDSCEYTHS
VIHTHSVSEYQKDSIGDQLFECPACGESFVHSSFLFEHQKIHEQDQFFG--HRRYDEPFM
QPLIIN--PHRPRASQKNP--PTGTSLQCCVCGRDFIHGSVLNEHMRIHTGEDLPE--QG
QR---SEEAVSPGLALTEFQRSQ--TEEKHYECKTCGESFLNQSDLRDHMRIHEK-DEPY
DYGVTFLHTSFIAEPPKRDSPFYECKDCGKSFIHSTVLTKHQKLHLEEEEAA--------
-----AAAQEVEANVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAEPNVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPNVD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGAGIEDPEEEGEDQEIQVEEPYYDCGECGETFASTSAYGEHLKTHARVIIFEP
GNVYGESSHYTEHASTS------------TSDNDRA-DDKYFKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MAKRRFGIER-DDRDSM--D-YESRSQDAESYQNV-VNLNQDRK
PQNPVQDNMENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSRRSVYPS--T----SRGLK
TMPEAKKPSHRRGICEDESCHGVIMEKFIKDVSRGPRSGRAREPEERP------------
------------QRLP--RMPDDNWKDAAFSRRES--VIQERGSEGSAFRG-GFRFNSSL
VSRKRVLERKRRYHFDT-----VHDHNGCVRKKPFDCGSEMRK---AMSMSSLSGLGSS-
--SYSESQ-SVDFGSMAYVCDECGRSFNVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKGQV-GGKRFECKECGETFNKSAALAEHRKIHA-RECRAERR---EQEHEETV
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIHNRGNFGEDKDNEREPERE------------------------REHREIFM
PNAALNEFQKMYNKEKIYECKVCGETFLHSSSLKEHQKVHTRGNPFENRSKVCEETFIPG
QSLKRRQKTYTKEKLFAFPDGRDAFMQSSDL-SERQKIHARKNFFESRAYEKSVIHSTPF
TESQKSHTI-TRPPEDEE--DEKAFTISSNPDEDQRVST-----TGRFYKRSVIHSFTPA
ETLRS-HSIAGPSQLKAV---AESTI-QSSAA---------ARSACEGKEHKRSVIHSLA
APRPLKRHSGNGQNECD-EKGESSIYISDLNNKRRKIAAR-ENPSEVGKNN----NYKDS
VMPSVSHAEPPRSLAGEGSSEFKQDAKFSLPSSNVREHQKARAKKKYIEHR---GNETSV
IHSL-HFGELQTVRPREKLYECQECGECFARSSDLTEHQKIHNREKPSGSRIYERSVIR-
---SLAPTDPQTSYAQERY----AEEQARYKRRESGQSSAFSSFFRARLNIYTQE-----
------------------------------------------------------------
-------------------------------------KSSGKATRGQ-------------
EP---------------------------------HS-----------------------
------RETRAREPQREETHAWEPRGKKT-------------------------------
-----LAQEPHG-----------------EETCAWK------------------------
-----PHGEEAHAQEPHREE----------------------------------------
----------------------TPAQEPY-----------------GKEICAQKPRG---
----------------------------E-----------------ET---------PAQ
KPH----REETPAQEPQ-------------------------------------------
------------------------------------------------------------
----------------------GEETRGQEPPG----EET-----------------HHQ
ETQSQETHGQKPHG----------------------------------------------
------------------------------------------------------------
-----------------KEPRGQEPRGQ--------------------------------
---------------------------------------EPCG----QEPHG------EE
------PRGQE---PHGEEPHGVEAHGEETH-DQEMVEDTVIQGSDL-------------
---------EERQKDDPDDTIYECQDCGLGFADLTDLTGHQDVHIR---KSVDSSKDTES
QVHVHSINEFSKEFTGEQLFECPKCGESFIHSSFLFEHQRIHEQDQLYS--MKGCDDGFI
SLLPV--KPRRNRAAERNP-ALAGSAIRCLQCGQGFIHSSALNEHMRHHREDE--LLEQS
EM---AEEVLIHGFALTEFQGSE--TEEKLFECTICGECFFTAKELGDHHTKVHK-DEPY
EYGPSYTHTSFLAEPFRKPMPFYECKDCGQAFIHDTVLTKHTVFHPEEEEEEEEEEEEEE
EEEEAAAAQEVEANVLVPQEILRIQGSNIEAAEPEVEVAEPEVEAAEPEVEAAEPNGEAE
GPGGEAAEPHGEAE----------QPIVD----ADEPDGVGIEDPEEGAQG-------PE
GDADGPEGLGVGDPEEEGEDEEIEVEEPYDGYKECTETFPCSAALGGPLKAQASMVMLEP
VGAPGECSGYIQRAST------------STGGTQPA-DEKHFRCDVCGQLFSDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDENSHRTMSD--KVTAMELPS-------------------------------
-----------------------------------PESGKVCEPRLEELLGNPEGQSLGS
SPS-------QDRGCK--QVTVTHWKIQTRETAQ---VCT-------KSG-RHPVLNSDL
LMLQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHRIL HAGEKP YTCDQCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIRYAG
LIE--HQHV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NQCGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKA--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNSA--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLPLSKAPIHLGERSADHGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

-----------------------------------GEGPTDSEFFHQRF---RNFLYVEF
V--GPRKTLNKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRA-------
----KKPENCEKLV---TLLENYKE----MYQPEDDTNSDVASDDDMSRNGGESPPPRSI
YSFS-D----------------------R----------DWDRRGRSRDAESRDCWK-YA
RSPRSRLLQRDLSFPVMAKPSFEMERDNDRDSM--D-YESRSQDTESYQNV-VDLTEDRR
PQNPIQDNMENYRKLLSL--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------
------------XXXX---XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXXXXXXX---XXXXXXX------X
XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
XXX--XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX---XX-XXXXX
XXXXX-----------------------------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX---XX--XXXXXXXXXXXXXXXXX----X------XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXX------XX
XXXXXXXXX-XXXXXXXX--XXXXXXXXXXSSSYRKLPTKENVYEGKPYEMSVIHSLASS
EAQKI-HDAVGPSKLKVV---AESTF-QSSDVINH-QKILAGGNTCEGKEYKRSVIHSLT
TLKPWKSHSENELVECN-EKGESSTYISYLNGKQ-QIPARE-SPYE----RGKKNNYKDS
VIQSVSHIESQKSLTGEGSSEFKQDGEFSVPSSNVRGPQKARAKKKYIEHR---DNETSV
IHSL-PFSKSPVVHPREKLYECQQCGQSFALSSNLTEHQKIHEREKPSGSRNYEQSVIR-
---SLAGTDPQTSYTQEQY----AEEQVRNKCKEMGQCFATSKDLCVHQKIYTQE-----
------------------------------------------------------------
-------------------------------------KAHDK------------------
------------------------------------------------------------
------------------------------------------------------------
--------EAYG-----------------EDSEGEE------------------------
-----V------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------HSEES-----H-GEVN-GQDKIEDSVIQGSDL-------------
---------DESQKDDPDDTIYECQDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSA IRCLVCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEIFIPGLALTEFQRSQ--TEESL FECTICGESFVNPSELGDH-ISV HK-NEPY
DYGASYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEFHPEEDDD-EE------
---EEATAQEVEVNVLVPREVLRIQGSNVEAAEQEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPKGD----ADEPDGA--------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

MLPPKYLSATKPRKSWAPDEYELDSDWSREPDAVLGEGATDSEFSHQRF---RNSLYVEF
V--GPRKTLAKLRNLCLDWLQPETRSKAEILELLVLEQFLTILPERIKPWVRA-------
----KRPGSCEKLV---TLLENYKR----MYEPDDD-NSDITGEDSMSRKA-DSPPPRPV
YSFXXXXXXXXXXXXXXXXXXXXXXXXXX-------------------------XXX-XX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXDADSVSYQDV-VDLAEDRK
PQNPIQDNMENYRKLLSL---VRLAENDGHSHMTQGHSSRSKRSAYPST------SRGLK
IMPETKRSTHRRGICEDESSHGVIMEKFIKDVSRNSKSARAREASDRP------------
------------QRFS--RRPDNDWRDISFNKRES--VIQERGYGGHAFGGGGIHFHSSL
ISRRRVLERKRRYHFDSEAKGSAHEQKSYARKRAFECGEM----RKALSMGNL------S
APSFTESHPV-DFASMPYVCDECGRCFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKRQS-GGKRFECKECGETFNKSAALAEHRKNHT-RQQQAEPK---DDEYEEPF
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGNFPEDKDRERG-------------------------------GESFK
PSPSLSNLQKMYGKDKLYECKICGETFHHSSSLKEHQKIHARGKPFENKPRVCEATYIPG
QKR-HQKTTYPKEKLCDFDDGPGAFMPLSD-----VKIHSRKNLYEARGYEKSVIHSMPY
TESQKSHTI-TRPPEDEEEEEEKAFTISSNPEEKQKLPIKGNAYHWKPYEMSVIHSLAFA
EAQKS-HSAARPIRPRVI---AESTIVQSSGSFEH-QRVRGGDNASEGRKYERSVIHSLA
TFKRPRSRSGYEFTNHS-ERGESSVYISDLTEKPPKILVR-EYPYEVGKSN----SYKGS
VIHSVSHTKPQKNLTGEGSSDFLKDGEATLPSSTVREHQKARAKKKNIEG---RNYETSV
IHSL-HFGEPRAVRPREKFYECQVCGESFIRNSDLTEHQKIHEQKKPSGSKNYERSVIR-
---SLASTDPQPSYTEPRAQTSYAEEPPH-------------------------------
------------------------------------------------------------
--------------------------SS--------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----YIDGTHQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-LH---------------------------------------------------------
------RTTSSD------------------PSADQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------YALEQGGESQTEN-
--------------TRRVAAHS-----EKPQAQKPFGGDSVIQSTGRDGPQE--------
---------DEDDDEDEEDSIYGCKDCGLGFADKADLKDHQKV HG--RDYLVDTREYKPS
VIHSPPVSEYQRDFNGEQL FECPACGESFVHSSFLFEHQKI HEQDQYYG--VRRYEEPFM
QPLIVA--PRRPRRPQKNS--PPGLF LQCQVCGEDFIHASVLNDHMRV HVGQNFAEPAEG
ET---SEQAMSSSLALTEYQRSQ--AEERQ YECRTCGAAFLSQSDLTEHMRI HEHDDQPY
DYGASFVHTSFLTELLKRDSPF YECKDCGKSFIHNTVLTKHQKLHVEEEEDAA-------
-----AAATQEVEAIVLVLEVLRIQG----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

MLPPKHLSATKPKKSRAPNLYELDNDLPKEPDVIVGEGPTDSEFFHQRF---RNLIYVEF
V--GPRKTLIKLRNLCLNWLQPETRTKEEIIELLVFEQFLTIIPEKLKPWVRA-------
----KKPENCEKLV---NLLENYKE----MYQPEDDTNSDVTSDEDTNPDGRESPQPHSV
HSFSD-----WD--------------RDR----------DWARRGRSRDVEPRGRWP-YS
RNPRSRLPRRDLSLPVMARTTFEMEREDNRDSV--D-CESRSQDAESYQNV-IDLTEDRK
PHNTIQDNMENYRKLLSL--EKGALL--------------------------------QV
PLSFSKKSTHRRGICEDESSHGVIMEKFVKDVSCSPKSGRAREPSDRL------------
------------QRFP--RMSDDNWKDISLNKRES--VIQERGDEGNAFRG-GFRFNSNL
VSKKRVTERKRRYHFDTDE-------KGCARKKPFGCSSEMRK---AMSMSSL------S
SPSFTNAQPVIDFASMPYVCDECGRSFGVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE-----GQA-GGKRFECKECGETFSTSAALAEHRQMHA-REYLAECEDQEDQEYEETF
MPSPT-----------------------------YTELQKIYGKDKFYACRVCKETFLHS
SALIEHQKIH----FGDDKDNERDRERE----------------------RDRER-EPFM
PSSTFNELQKMYGKEKLYECKVCGETFLHSSSLREHQKIHARGNPFENKGKVCEETFIPG
QPLKRRQKTYSKEKLCDLNDGRDAFMQSSDF-SERQKIHSRRNLFEGRGYEKSVIHSVPF
TESQKSHTI-TRPPENE----EKAFTISSNPSENQKFPTKEDVSEGKPYERSVIHSLASA
EAQKS-PSAVGPIKPKVI---AESTI-QSSDVINH-QKVHAGGNTCEGMEYKRSVIHSLA
APRPLNIHNGNELLECT-EKGECSIYISDLNDKQQKIPAR-EKPYEASKNN----NYKDS
VIQSVSHATPQKRLTGEGSGEVKKDGEFSVPSSNVRTYQKARAKKKYIEHR---SNETSV
IHSL-PFGKQETVRPREKLYECQECGESFACSYDLTEHQKIHDREKPSVSRNYELSVIR-
---SLAPADPQTSYAQEQY----AKEQAHIKCMEFRQCFATSKDLNTHHKTSTQE-----
------------------------------------------------------------
-------------------------------------KSHGEETRGE-------------
ET---------------------------------Q------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GEETCSEEIH-GQEMVEDSVIQVSEV-------------
---------AEPQMEDPDDTIYECQDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VTHTHSISEYHRDYTGEQL FECPKCGESFIHSSFLFEHQRI HEQDQLYS--LKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGLGFIHSSALNEHMRLHREDD--LLEQS
QMAEMAEEAVIPGLALTEFQRSE--TEERLFECAICGESFFDAAELAD-HVSVHK-NEPY
EYGSAYTHTSFLTEPLQGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEEEEEE----
-EGGGAAAQEVEVNVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAQPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPS---GEADQPSGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGAGIEDPEEEGEEQEIEVEEPCYDCHECTGAFTSCAAFGEHLKTHASLVIFEP
AGAFGGCSGYIEGAST------------STGGAGRA-DEKYFRCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LHDGKKPH---KC-----------------SECL
LLHYP--------------------------------------------K----------
-NSNLTRHRRIHTGERPYECSECGKSFSRSSHLIVHQRI HTGERP YECSKCGKRFQTSSD
LLK--HYRV HR-EERP FCCPDCGKGFRENSKLIRHRRI HT-GERP YECS-----ECGKSF
SQSSS-----------------------------LIMHQRTHTGERPYECSKCGKRFQTS
SCLLRHYWVHMEERPF----------------------------------CCPDCGKGFR
FNSTLIQHRRI HSGERP YECPRCGKRFSQSSHLTKHQRRH--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSE--KLPVMESSA-------------------------------
-----------------------------------PESGEDPEPRLGGLLRNSEGQSLRN
S-S-------QAAGFR--QVTVTHWKIQTGETAQ---MCN-------KSG-RSPILNSNL
LILQREL----------------------IEEEAHQC-DSCGKS---FTF----------
-HSDLIRHQLS HSGEKV YKCDHCGKGFSQSSHLTEHQRI HTGERL YVCNVCGKNFIHYSN
LIE--HQRI HT-GEKP FKCTQCGKAFCHSSDLIRHQRV HT-RERP YECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-ERP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSHCGKGFIQRSN
FIQHQKIHTEEKLYECS-QYE------KDFNPT--------------------------P
NFKNN------QC-----------------------------------------------
VHQEGLDLNKAPIHLGEKSIGRTCCGTSW-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------CS-RPLCAGSML
GRHQQLH----------------------DGKKPHKC-SECGKS---FRW----------
-SSDLIVHQRT HTGEKP YECGECGKGFSRSSDLIVHQRIHT-------------------
-----------------------------------------GERPYECG-----ECGKSF
SRSSS-----------------------------LIMHQRIHTGERPYECSKCGRRFQTG
SRLLRHYPVHTEERPF----------------------------------HCPDCGKGFR
DNSKLIQHRRI HTGERP YECPRCGKSFSQSS-----------------------------
-ILTRHQRRH--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

MLPPKHLSVTKPKKSWAPNLYELDSDLTKEPGVIIGEGP--------RF---WNLICVEF
V--GPQKTLIKLQNLCLDWLQPETCTKEEIIELLVLEQYLTIIPEKLKPWVPA-------
----KKPENCEKLV---TPLESYKE----MYQPEDDNSDVTTSDDEMTRNRGESPPPRSV
YSFS-DR--------------------------------DWDRRGRSRDREPRGRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNM-VNLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDLSLNKRES--VIQERVYEGNSFRG-GFRFNSTL
VSRKRILERKRRYHFDTDGKGSTHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPV-DFGAMPYVCDECGRSFSVISGFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQI-GGKRFECKDCGETFNKSAALAEHRKIHA-RDYLVECK---DQAYEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDGKDNDRERERE----------------------RERERGEAFM
PSSTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHARGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNIFEGRGYEKSVIHSMPF
TESQKSHTI-TRPPESDE--DEKPFTISSNPFENQ-IPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFEAINH-QRVRAGGNTSEGRGYSRSVIQRLV
ASKLPKSHNGNELVESN-ENGESSIYISDLNGKRLKIAAR-ENPCEGGSKS-H--NYEDS
VIQSVSHAKPQKSVSGKGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGKQQTHRPRGMLYECQECGECFAHRSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKYKEFRQSFATNKDLNTHQKNYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKKSQD--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------EEMHGEETH-GQEIIEDPVIQGSDM-------------
---------EEPQKDDPDDTIYECEDCGLGFVDLTDLTDHQKV HR--RKCLVDSREYTHS
VSHTHSISEYQRNYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--LKGCDDGFI
ALLPV--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALAEFQRSQ--TEERLFECAVCGESFVNAAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAMPFYECKDCGKSFIHSTVLTKHKEL HLEEEDD------DDD
DEAAGAAAQEVEANVHVPQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPE-EGEDQEIQVEEP YYDCHECTETFTSSAAFGEHLKT HASMIIFEP
ANAFGECSGHIERAST------------STGGADQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHQEDDTNSDMTSDDDMSRTGRETPPPRSS
HSFSSD----------------------R----------DQERRGRSREVEPRDRWP-YN
RNPRSRLPQRDLSLPVMSRSHFGLERD-DRRSL--D-YESRSQDAESYQNI-VDRNEDKS
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRSAYPRRITSGGLFPGLK
PMPEGKKPAHRRGICEEESSHGVIMEKFIKDVSRSSKSGRAREPNER-------------
----------PPPRFP---RPSDNWKDSSSTKRES--VIQERAPEAGTFRG-AFRVNTEL
LSRSRALERKRRYHFESDDK--GHESKSCVRKKPFECGSEMRQ---AMSMGNV------N
SAPSTDAQPIDPLGADPYVCDECGRSFGVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGKRFECKECGETFRRSAALAEHRQTHA-REYLAEGR---DQDDEDAV
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGNPG---DDERQRERERMRARAREQREQRERERERERERE-REREPFL
TCPNFNEFHNMYRKEKFYECKVCGESFLHLSSLREHQKIHTRGNPFENKNRACEETFVPS
QALKRRQKTY-REKLFEFNNARDALMDGAGP-GDHHKNRPRKSFFEGRAFEK------PF
TESHKSHTI-TRPPENKD--EDKPFTISANPNDKPKAPAAEGGSQGKPFQRSVI------
------RGALGFTKPKPV---AESST-QTSGVFTH-PRALSAASAYDGKDYKGSLIHSLP
VPRALKRHRASGQGECSSDDGEPSIYMPDLTSKRRKIPGAGEDAYTGSSSLGLGLGRRDP
ILPIVPRAE-PPTLSAE-SRDSSQDVTFSVPSSSVREHQKARAKKKYMEPR---SNETSV
IHSLGPFGDLQAIRRRPKIFECQECGEAFARRSELIEHQKIHDREGPSGSRLFERSVIRG
RSRSLVPGDPQTSYAQERF----VQEQVRK-FRAFAQRSATSN-SLGVQKIYNQE-----
------------------------------------------------------------
-------------------------------------KYYAEEPHGK-------------
DT---------------------------------LG-----------------------
------HKSHD-------------------------------------------------
-------TEPQG-----------------QKPHGDE------------------------
-----P-----QDQ-----E----------------------------------------
----------------------MRS-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---SEEARGDQPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPQDQ--------------------------------
---------------------------------------EPQD---------------QE
------MRSSS-----------DGPRGDEPH-GQQSPRQAPAS-GSN-------------
---------ERHRHDDVGDTIYECQDCGLGFADLSDLTSHQDV HS--RKSLVDSREYAHS
EVHAHSLGEFEKKFSGEKL YECPKCGESFTHSSLLFEHQRI HEQDQLHSSSAKTSDDGLV
ALMPA--RPRRNRGNEASTAAVSGSAI RCRQCGQGFIHSSALNEHMRQHRDEEAAAMEQG
EL---AEDMFIQGLALTEYQGSE--TEEKLFECTVCGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKRMPLYECKDCGQPFLDDTFIDERMVFHHR-DGSDIV------
---AAPAARDGEANALVPQEALRIQGSNAEMAEPEVEAAEPEVEAAEPEVEAAEPDGEAE
GPEGEAAEPDGEAEQPN---GEAEQPNGE----ADEPDGAGIEDPEERAVAA--------
AAAAAPDVADLEDPEEEGEDQEIEVEEPYYNCHECTETFATSAAFGEHLKSHASVIIFEP
ANAPGECSGYIEHASTS------------AGGAEQA-DDKYFKCDVCGQLFHDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------IILFSFVSDS----------KAG-----
--IDWISEDENLHSTTSD--KLTVMEPLI-------------------------------
-----------------------------------PESREVCEPRLGELLGNAEGQSLGS
SPS-------QEGGFK--QMTVTHWKIQTGETAQ---ACS-------KSG-RNPILNSNL
LILQSEL----------------------IAEETHPC-DICGKS---FTF----------
-NSDLVRHQIS HTGEKL YKCDQCGKGFGQSSHLTEHQRV HTGERL YVCNVCGKDFVHYAN
LLE--HQQV HT-GEKP FRCTQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYEYS-QYG------KDFNST--------------------------P
NFKNN------PG-----------------------------------------------
VHQEGSP-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AMSD--RLTVMEHPT-------------------------------
-----------------------------------SESREVHETRLGKLLGNREGQNLGS
PPS-------QEDGFK--QVTVTHWKIQTGETAQ---MCS-------KPG-RNPILNPNL
LILQREI----------------------IEGEAHPC-GICGQT---FPF----------
-NSDLIRHQISHTGEKPYKCEDCGKDFSQTSHLTEHQRAHTGNRLYVCNVCGKDFIHYTN
LAE--HQQVHT-GEKPFRCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLVEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSFCGKGFIQRSN
FLQHQKMHTEERLYECS-QLE------EGCTPP--------------------------S
DF----------------------------------------------------------
IHQEGLSLSETSTCLGERSTGQEGHMDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G-RRWSQSSEL
GVPEQLH----------------------DGEKPHKC-SECGKS---FRW----------
-RSHLIVHQRA HTGERP YECGECGKSFSRSSSLIKHQRIHTGEKPYECSECGKRFQRSSY
LLL--HYPVHR-EERPFCCPDCGKGFRQNSNLIRHRRI HT-GERP YECS-----ECGKSF
SRSSH-----------------------------LIVHQRI HTGERP YECSKCGKRFQTS
SDLLRHYRVHTEERPF----------------------------------CCPDCGKGFR
ENSKLIQHRRIHTGERPYECGECGKSFSQSP-----------------------------
-SLIKHQRT HTGERP YECGECGKSFTHSSSL-IKHQRIHTGERPY---------------
-----------EPFRCPD--CGKGFI----------------------------------
---------------------------HNSTLIQH-RRI HTGERP FECPRCGKRFSQSSN
LTRHQRRH----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

MLPPKSLSATKPKKSWALNLYELDSDLS-EPDSVPGEGATDSEFFHQRF---RNFLYVDF
I--GPRKTLLKLRNLCLDWLQPETRTKEEIIEILVLEQYLAILPERIKPWVCA-------
----QKPETCEKLV---TLLEQYEE----MYEPEDDNSSDTHSEGGMSRRAAESPPPRPA
LPCCRE---------------------------------GERRRGRSRDMESRDRWP-SV
RSPRSRFHQRDLALPLAER---AKEREHRRRDSLLD-LDARSEEAVLYQDM-VALTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGNSHMTQGHSARSKRSAYPST------SRGLK
-APETKKSAHRRGICEAESSHGVIMEKFIKDVARSSRSGRVREPSERP------------
------------HRLS--RRAGGDWKEASFSRREA--GASERGPEGGAFGGGGFSCSSDP
VSKKRALERKRRYHFDVEGQGPVHDPRGGARKRPFESGGEARRGAKAAGASSL------S
APPVALSQPL-DVAAMPHVAA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------ATSSSDF-MEHQKIHSRKSYFDSRGYEKPLLHSMPM
PSSQKSHTI-TRPPEDED--EEKAFTASSNPEDGQEAR----------------------
--------------------------------------------AYERSTYERAIFHSLA
AFRPPRSL--------R-EDGEPSTYFSGLRDPPQKPPAW-ESPYAGGRHS----FFRSS
VFYRASRPAPLDHL----------------------------------------------
---------------------------------------------------SYLRSALR-
---SLSSTDPQTSYQSQSVQIGYAQEAAQTSYAELAAQTSY--AELAAQTSYAEEPAQTS
YTEAPAEGSYTEEPAQTSYTEAPAEGSYTEEPAQTSYTEAPAEGSYTEEPAQTSYTEAPA
EGSYTEEPAQTSCIEEPAQTSCI-EPAQTSYTDPAAETSFSEEPAQTNYTEAPAETSYTE
EPVQTSCIEEPAQTSYTDPAAETSYTEEPAQTNYTEGPAEASCIEEPSQTNYTEGPAEAS
---------CIEEPSQ--TNYTEGPAEASCIEEPSQTNYTEGPAEASCIEEPAQTSCIQE
PAQTSCIQEPAQTSCIQEPAQTSCIQEPAQTSCTQEPAQTSCT---------Q---EPAQ
TNYTDPAADTSHTEEPAQTNYTEESAEASYTEEPAQTSCIEEAAQTRYSDPAADTSYTEE
PAQTSYTKEPAEASYTEAPAQTSCIEEPAQTNYTEESAEASYTEEPAQTGCIEKPAQTSY
TDPAAETSYTKEPAQTNYTEDSAEASDTEEPAQTSCLEEPAQTSYTDPAAETSYTEEPAE
TSYTEEPA---------ETSYTEEPAETSNTEEPAEASYTEEPAEASYTEEPAQASYSEE
PAQASYTEEPAQTSCSEEPAQTSYAEEPAQTSYAEEPAQTRYAEKPAQTRYDEEPSQTSY
SEEPAQTSYAEEPAQTSYAEEPAQTSYAEEPAQTSYAEEPAQTSYAEEPAQTSYANQLRS
DIWRNQLRPDMPKNQIRPVILRNQIRPVMPRNQLRPVILRNQLRSLMLRNQLRPVILRNQ
LRPLMPRNQLRPVILRNQLRPLYAEEPPAETSYAELVAQISYAELAAPTSYAELAAETGY
FEPPTQTSYTEPAETNYAEPAAQVSFDEPPAEASYADLAAEISYAELAAETSYADLTAHI
SYDEPPAETSYAELAAQISYSEPAVQTSYAELAAETSYSEPLAQTSYAELTSETSYCEQP
--------------------------------DGKLFGEPVMQDLGLDGSPEE-------
------ELEEQEEPEEPEDSIYGCKDCGLGFADRADLRDHQKVHG--RRCLVDSREYTHP
AVHMPP------------------------------------EQDQFYG--HRRY-EPLT
QPPIAS--PR--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------SQ----------
-SSELGVPEQLHDGEKPHKCLECGKSFSRSSSLIVHERI HTGERP YQCSKCGKRFQTSSD
LLR--HYRV HR-EERP FCCPDCGKGFRQNSNLIRHRRI HT-GERP YECP-----RCGKSF
RQSSS-----------------------------LIMHQRTHTGERPYKCSKCGKRFQTS
SCLLKHYQVHREERPL----------------------------------CCPDCGKGFR
DNSDLTRHRRI HTGEKP YECGECGKS------------------------------FRTR
SELILHQRT HTGEKP YECGECGKGFSRSSSL-IMHQRTHTEERPYECSKCGKRFQTTFHL
VKHYRIHT-EERPFCCPD--CGKGFR----------------------------------
---------------------------DNSDLTTH-RRI HTGERP YECGECGKRFSRNSH
LTEHQRRHRRAKLH----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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-------MLENYRNLICL--GLAMYKPDV-------------------------------
----------------------------------ICQLERREAP------GMSEGAVPQS
CCADAKITPEPKKSFSKF---VTSSEESSGQITEDH-CCFSKQKEASKLNVRLKRNCHDE
EIQSRIH----------------------PIEKPYKR-DKYGKA---LPR----------
-GSELAAHCRILTAVRTYRCNECGKAFSQRSHLVGHQRI HTGEKP YECKECGKAFRWTTG
LTQ--HQRIHT-GEKPYECNECGKAFTQSSQCTQHQRIHA-GEKCYKCK-----ECGKVF
SQRSQ-----------------------------FIVHQRS HTGEKT YECNDCWKVFKWY
SHLTQHQRI HTGEKPY----------------------------------ECDECGKAFS
FRAGLTVHQRVHTGEKPYKCDECGKAFRQISHFNLHQTIHTRKKSHEC--KECRETFRWK
LERELHQXXXXXXXXXXXXXXXXXXX----------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNNSDVTSDDDMTRNRRESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-HT
RNPRSRMPQRDLSLPVVAKTSFEMDRDDDRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDISLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNEREHER------------------------ERERGETFR
PSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKKRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPRSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-ENPCEGGSKN-R--NYEDS
VIQSVSRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKCKEFRQFFATSEDLNTNQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGEESQGE-------------
NT---------------------------------DG-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHSEETH-GQETIEDPVIQGSDM-------------
---------EDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEER LFECAVCGESFINPAELAD-HV TVHK-NEPY
VYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEEE-DEAA-A--
--AAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAGQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AMSD--RLTVMEHPT-------------------------------
-----------------------------------SESREVHETRLGKLLGNREGQNLGS
PPS-------QEDGFK--QVTVTHWKIQTGETAQ---MCS-------KPG-RNPILNPNL
LILQREI----------------------IEGEAHPC-GICGQT---FPF----------
-NSDLIRHQISHTGEKPYKCEDCGKDFSQTSHLTEHQRAHTGNRLYVCNVCGKDFIHYTN
LAE--HQQVHT-GEKPFRCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLVEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSFCGKGFIQRSN
FLQHQKMHTEERLYECS-QLE------EGCTPP--------------------------S
DF----------------------------------------------------------
IHQEGLSLSETSTCLGERSTGQEGHMDNL-------------------------------
------------------------------------------------------------
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---------------

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-------------------------------------------R---SSQ----------
-SSELGVPERLHDGEKPHKCSECGKSFSRSSHLIVHQRI HTGERP YECSKCGKRFQTSSD
LLK--HYRV HR-EERP FCCPDCGKGFRENSKLIRHRRI HT-GERP YECS-----ECGKSF
SQSSS-----------------------------LIMHQRTHTGERPYECSRCGKRFQTS
SCLLRHYRIHMEERPF----------------------------------CCPDCGKGFR
FNSTLIQHRRI HTGERP YECGECGKRFSRNSHLTEHQRRHRRAKLH--------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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-----------------------------MYQPEDDNNSDVTSDDDMTRNRGESSPPHSV
HPFGGER--------------------------------DWDRRGRSRDMEPRDRWP-YT
RNPRSRMPQRDLSLPVMAKTSFEMDRDDNRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDVSLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLMECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RERERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKPYDFTDSRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNRYENQKIPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPRSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-ENPCEGGSKN-H--NYEDS
VIQSVSRAKPQKSVLGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHTL-PFGE-QTFHPRGMLYECQKCGECFTHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKCKEFRQFFATSKDLNTNQKLYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKESQGE-------------
KT---------------------------------HG-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHGEETH-GQETIEDPVIQGSDM-------------
---------EDPQKDDPDDKIYECEDCGLGFVDLTHLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRATERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERL FECVVCGESFVNPAELAD-HVTV HK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEEE-DEAA-A--
--AAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEP YYDCRECTETFTSSTAFGEHLKT HASVIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----VSGRGNLQKAVSE--TLPVMELTA-------------------------------
-----------------------------------PTSGRGPDPRLGRLLGNLDAQSLRS
CTS-------QEGGFQ--QVTVTHWKIQTAEGAQ---VGS-------KSE-GSPLLSPDL
LLLQREL----------------------IEGEAPQH-EACG-S---FPF----------
-NPGLARHQASHAGEKAHRCDECGKGFSQSSHLVEHHHAHGEERLYVCNACGKDFVLYTD
LME--HQKVHT-GERPFKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKAFIRS
SSLIRHFQV HTEVRQY----------------------------------ECQDCGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHSG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------KEFTPP--------------------------P
DFNSS------QE-----------------------------------------------
APQEGLPLSQTAVHLGETVMDGRGCHLSL-------------------------------
------------------------------------------------------------
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---------------

MLPTKPLSASKHKKFWAPNLYELDSDLSNEPDAIVGEGPTDSEFFHQRF---RNFLYVEF
V--GPQKTLIKLRNLCLNWLQPETRTKEEIIELLVLEQYLTIIPERLKPWVRA-------
----KKPGSCEKLV---TLLERHNH----MYQAADDYSDVTASDADM-RRNRESPPPRPE
RSFS-D----------------------R----------DWNRRGRSRDLEPRDRWA-YP
RSARSRLPHRDRSLPILSKPSFEMDREDDRDPP--D-YEPQSQDDESYQNA-MDTDDDRK
PQNPIQDNMENYRKLLSL---VQLAEYDGHSHMKQGHSSRSKRSAYPSTSRXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX-------------
------------XXXX---XXXXXXXXXXXX--XX--XXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXX--X--XXXXXXXXXXXXXXXXXXXXX---XXXXXXX------X
XX-XX-XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
XXX--XXXXXX-XXXXXXX--XXXXXXXXXXXXXXXXXXX-XXXXXXXX------XXXXX
XXXXX-----------------------------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX---X---XXXXXXXXXXXXXXXXX----X------XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-XXXXXYLKEKLCGFMPSSDF-SAYPKLRSRKSLFEGQGYGKSIVHSMPF
TESQKSHTI-SKPPEEEE--DEKVPASSSSASASQGSPAGENTSERKLCESSVTHSLASA
ATPRS-RAAGGPSKPWVMADST-----EPSSSVGSSQKMCAGGTSYEGKESMRSVIHGLA
APRPLKRHLMNDLSGCD-ERGESSIYLPDLGHKRYKIIAR--EPYEGASKI-----REES
VIQGVALASQK-------------------------------------------------
------------------------------------------------------------
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---------------

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-----------------------------------------GRR---WNQ----------
-SSELGVPEQLHDGEKPHKCSECGKSFSRSSHLIVHQRI HTGERP YECSKCGKRFQTSSD
LLK--HYRV HT-EERP FCCPDCGKGFRENSKLIRHRRI HT-GERP YECS-----ECGKSF
SQSSS-----------------------------LIMHQRTHTGERPYECSKCGKRFQTS
SCLLRHYWVHREERPF----------------------------------CCPDCGKGFR
FNSTLIQHRRIHTGERPYECGECGKRFSRNSHLTEHQRRHRNKKPHKC--SECGKGFRRR
RELILHQRTHTGERPYKCGECGKSFSQSSSL-IKHQRIHTGERPYQCSKCGKRFQSSSCL
LRHYRVHR-EERPFCCPD--CGKGFR----------------------------------
---------------------------ENSKLIRH-RHIHTGERPYECSKCGKSFQTSSD
LLKHYRI HTEERP FRCP-DCG------MGFNRN--------------------------S
HLTRH------RR-----------------------------------------------
I HTGE------------RP YECGECGKRFLRNSHLTKHQRRH------------------
------------------------------------------------------------
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---------------

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------------------CPDCVKGFRDYSHLLRHQRI HS-GEKP YECS-----ECGKSF
SRSSS-----------------------------LIVHQRTHTGERPYECSKCGKGFQTS
SCLLRHYRVHMEERPF----------------------------------CCPDCGKGFR
DNSTLIQHRRI HTGERP YECPRCGKRFSQSSHLTRHQRRH--------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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-----------------------------MYHHEDDTNSDMNSDDDMSRSGRETPPPRPS
HAFGSE----------------------R----------DLERRGRSRDVEPRDRWP-HT
RNPRSRLPQRDLSLPVMSRPHFGLERDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRTAYPST------SRGLK
PTPDAKKPSHRRGICEDESSHGVIMEKFIKDVSRNPRSGRARELNGR-------------
----------PPPRFP---RPNDNWKDSSSSRRES--VIQERGYEGSAFRG-GFRFNADL
ASRSRALERKRRYHFDSDERGSGHEHKSCVRKKPFECGTEMRQ---AMSMGNL------S
SPSFSESQSID-FGANPYVCDECGRQFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGKRFECKECGETFSRSAALAEHRQIHA-REYLAECR---DQEDDETI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNSD-DRDNERERERDRLRARAREQRER-ERER----ERERELGEPFL
TCPNFTEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRVCEETFVPS
QSLRRRQKTY-REKLFDFNNARDALMGSSDP-SEHQKNRSRRNFFEGRGFEK------PF
TESQKSHTI-TRPPGNKD--DDKPFTISVNPNDKLKFPTMENGSQGKSYERSVIHSLGSA
DAQKS-HGGLGFSKPRPV---AESST-QSSSSINY-PRAHSGGNAYEGKEYKDSIIHSLP
APRPLKRHRANDHIQCD-EEGESSIYIPDIINKRRKIPA-REDAYEGSSSS----NY---
HTPNVSRAE-PPSLSGE-SHDSKQDVTFSVPSSSVREHQKARAKKKYIEPR---NNETSV
IHSL-PFGELLAGHRRAKFFECQECGEAFARRSDLIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FRAFGQCSTASS-NLSVQKIYAQE-----
------------------------------------------------------------
-------------------------------------KFNAEEPHDK-------------
ET---------------------------------HG-----------------------
------QNIHD-------------------------------------------------
-------KEPYG-----------------KEPSGKE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
----------------------MRSEEPH-----------------DDK-----------
-----------------------------------------------P---------HDD
KPH----GQEPHG-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------QEPHG----------------------------------------------
------------------------------------------------------------
-----------------DEPHGDEPHDK--------------------------------
---------------------------------------EPID---------------QE
------MRSEE---PHGE---------EESH-GQEKVEDATIQASVS-------------
---------EEHQKDDAGDAIYECQDCGLGFTDLNDLTSHQDTHN--RKALVDSREYAHS
EVHVHSVSEFEKKYSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQMYS--VKACDDGFI
ALLPV--RPRRNCTVERNP-AVSGSAIRCRQCGQGFIHSSALNEHMRQHRDNE--IMEQS
EL---ADEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEI------
---VAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECAETFASSAAFGEHLKSHASVIIFEP
ANAPGECSGYIERASTS------------AGGAEQAD-DKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MQLPS-------------------------------
-----------------------------------PEPEEVHEPRLGELLGNPEGQSLGS
SPC-------QDRGCK--QVTVTHWKIQTGETAQ---VCA-------KSG-RNPILNSDL
LLLQREL----------------------IEGDANPC-DICGKT---FTF----------
-NSDLVRHRISHAGEKPYRCDQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKDFIHYAG
LIE--HQRVHS-GDKPFKCAQCGKAFGHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHSG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYACSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNST--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKAPIHLGERSVDQGQHIDNL-------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
-------------NLCLNWLQPETRTKEEIIELLVLEQFLTIIPDKLKPWVRA-------
----KKPENCEKLV---TLLENYKE----MYRPEDDTNSDMTSDEDMSQDGGETPPPRAG
HSFSSDQDRD------------------Q----------NLDRRGRRRDMGPRDRWS-YS
RSPRSRLPQRDLSLPVMAKTTFEMERDDDRDSM--D-YESRSQDAESYQNV-TDPAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPDAKKSAHRRGICEDESSHGVIMDKFVTDVSRSSKSGRTREASDQP------------
------------QRFP--RTSDDNWKDVSLNKRDS--VIQERACERNAFRG-GSRFNSDL
ASRKRVLERKRRYHFDTDGNNSTHDQRGCARKKPFECSSEMRK---AMSMSSLS---SLS
APSFTDSQPVVNFGDMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIRSVA
VSE--VQKSQT-GGKHFECKECGETFNKSAALAEHRKIHA-REYLMECK---DEEYEETF
MPSPT-----------------------------FTELQKIYGKDKFYRCRVCKETFLHS
SALIEHQKIH----FGDDKDNERQRERE----------------------RQRERERPFM
PSSTFSEFQKMYGKEKVYECKVCGETFLHSSSLKEHQKIHARGNPFENKGKVCEETFIPG
QSLKRRQKTYPKEKLYNFDDGRDAFMQSSDI-NEHQKTHPRKNLFEGRGYEKSVIHSVPF
TESQKSHTI-TRPPENEE--EERAFTISSNPNKNQNFLIKENVYEGRPQERSVIHSLASA
EAQNS-HSAAGPFKLKVI---AESTI-QSSDVINY-QKVCAGGNTCEGMEYKKSVVHSLA
ASKPLKIHNGNELVECN-EKGESSTYISDLNK-QQKIPAR-EKPYEGGKNN----SHEDS
VIQSVSHAKPQKSLTGEGSGELKKDGEFSVPSSNVREYQKARAKKKYIERR---GKETSV
IHPL-PFGERYTVHHREKVYECQECGESFAYSYDLIEHQKIHDREKPSGSRNYEHSVIH-
---SLAPTDPQTSYAQEQY----IKEQARIRYNEFRQWFATSEDHNTHQKNYTQE-----
------------------------------------------------------------
-------------------------------------KSQGEDTHGE-------------
MT---------------------------------HG-----------------------
------------------------------------------------------------
-------EEMHG-----------------ETTNGKE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------T----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------H--EEETPDSVIQGSDM-------------
---------DESQKEDPDDTIYECQDCGLGFVDLTDLTDHQKVHS--RKCLVDSREYTHS
VIHTHSISDYQREYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYS--MKACDDGFI
ALLPT--KPRRNRAAERNP-ALAGSAIRCLLCGQGFIHSSALNEHMRLHREDE--LLEQS
QM---VEEAIIPGLALTEYQRSQ--TEERLFECAVCGESFVEAAELAD-HISVHK-NEPY
EYGPSYTHTSFLIEPLKGAIPFYECKDCGKSFIHTTVLTKHKELHLEEEEDEEE------
----VAAAQEVEANVLVPQ-VLRIQGSNAEAAEPEVEAAEPEMEAAEPEVEAAEPDGEAE
GPDGEAAEPSGEAEQ--P-NAEAEQPIGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPEEEDEEEEIEVEEPYYDCHECPETFSSSAAFGEHLKTHASMIIFEP
ANAFGECSGYIERAST------------STGGADQA-DEKYFKCDVCGQLFSDLLSLARH
QNTHTG---------

MLPPKPLSATKPKKFWAPNLYELDSDLTKEPDAIVGEGPTDSEFFHQRF---RNLLYVEF
V--GPRKTLIKLRNLCLDWLQPDTRTKEEIIELLVLEQYLTIIPEKLKPWVQA-------
----KKPENCEKLV---TLLENYKE----MYQPEDDNNSDIPSDDDMSRNGGETPPPRSE
HSFSSDRDQDHD--------------WDQ----------DWNRRGRSRNVEPRDCWS-YP
RNPRSRLLQRDLSLPVMAKTSFEMEREDDRDSM--D-YEPPSQDVESYQNV-MDLNEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TIPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRASKSGRARESTDRP------------
------------QRFP--RMSDESWKDVSFTKRES--VIQERGYEGNEFRG-GFRFNSNL
VSRRRVLERKRRYHFDTDGKGSTWDQR--ARKKPFECGSEMRK---ALSMSSLS---SIS
SSSFSGSQPA-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQA-GGKRFECKECGETFNKSATLAEHRKIHA-REYLAESN---DQEYEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGNFSDDKDNERE--RQ----------------------REHERGEAFM
PSSAFNEFQKMYGKEKIYECKVCGETFLHSSSLREHQKIHTRGNPFENKGKICEETFIPG
QSFKRRQKTYTKEKLYDFTDGRDAFLS-SDI-SEHQKIHSRKNLFESRGYEKPVIHNMPF
TESQKSHTI-TRPPENEE--EEKAFTISSNPSGNQKFPLRENVYERKPYERSVIHSLAST
AAQRS-YIAVGPSKLKVI---AESTF-QSSNVISY-QKIRTGGNTYEGKEYKRSVIHSLA
APRPLKRHIVSDLGGCD-ERGESSIYISDLSNKRQKIPAR-ENPYESDVNN----SHEDS
VLQSVSYVRPQKSLAGEGSSELKQDGEFSVPSSSVRQHQKARAKKKYIEHR---SNETSV
IHSL-PFGELQRIRPRERLYECQECGESFARISDLTEHQKIHDREKPSGSKNYEQSVIR-
---SLAPTDPQTSYAQEQY----AEEQARNEF-KFRQRFTNSNNLSTHQKIYAQE-----
------------------------------------------------------------
-------------------------------------KSHGEEPRGE-------------
EP---------------------------------RG-----------------------
------------------------------------------------------------
-------KEPHG-----------------EETHGEQ------------------------
-----TPEEMNPEEETHGQE----------------------------------------
----------------------TPEEE---------------------------TRG---
----------------------------Q-------------------------------
--------------ETP-------------------------------------------
------------------------------------------------------------
----------------------GKETRGQETPG----EET-----------------RGQ
ETPGEETRGQETAG----------------------------------------------
------------------------------------------------------------
-----------------QETRGQETPDE--------------------------------
---------------------------------------ETRGQETPDETHG------EE
------THGEK---TPGEETRGQETPGEETH-GEETVEDAVIQGSDL-------------
---------DEPQKDDPDNTIYECQDCGLGFVDLTDLTDHQNVHSTNTKCLVDSREYTHS
VIHTHSISEYQREYTGEQLYECPKCGESFIHSSFLFEHQRVHEQDQLYA--LKGCDDGFI
SLLPV--KPRRNRAAERNP-ALAGSAIRCLQCGQGFIHSSALNEHMRLHREDE--LLEQS
EM---AEEAIMSGLALTEFQGSE--SEEKLFECTICGECFFTASELGDHHIKVHK-DEPY
DYGPSFTHTSFLTEPLKGAIPFYECKDCGKSFVHSTVLTKHKELHPEEDDDDDDD-----
----DDSAQAVEANVIVPQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPNGEAGEAEQPEGD----ADEPDGVGIEDPEERVEE-------PE
GDADEPDGAGVEDPEEEGEDQEIEIEEPYYNCQECTETFTSSAAFGEHLKTHASVIVFEP
ADAFGECSGYIERASTSTSTSTSTSTSTSAGGADQA-DEKYFKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MILFSFISDS----------NAGIGEKK
GTL---------KTGFLR--MKILMEPLT-------------------------------
-----------------------------------PESREVCEPRLGELLGNAEGQSLGN
PPS-------QEGGFK--QVTVTHWKIQTGETAQ---SCS-------KSG-RNPVLNSNH
LILQSEL----------------------IEGETHPC-DICGKS---FTF----------
-NSDLVRHQIS HTGEKP YKCDQCGKGFGQSSHLTEHQRV HTGERF YVCNVCGKDFIHYAN
LLE--HQQV HT-GEKP FRCTQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------KDFNST--------------------------S
NFKNN------PG-----------------------------------------------
VHQEGSP-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNSSDVTSDDDMARNRGESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRLPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEVRK---AVSMSNLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKVH----FGDDKDNER----E----------------------RERERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESAI-QSFDAINH-QRVRAGGNTSEGREYSRSVIYSLV
TSKPPRSHSGNELVESN-EKGEFSIYVLDLNDKRQKIPAR-ENPCEGGSKN-H--NYEDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLSPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDLNTHQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSRGEESQGE-------------
KT---------------------------------RG-----------------------
------------------------------------------------------------
-------EETH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GEETYSEETH-GKGTIEDPVIEGSDM-------------
---------EDPQKDDPDDTIYECEHCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERL FECAVCGESFVNPAELAD-HVSV HK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEDDDDDEA-AA-
---AAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDICGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------EGKRPT---LGR-------GGG-RRWSQSSEL
GVPEQLH----------------------DEEKPHKC-SECGKS---FRW----------
-RSELIRHRRI HTGERP YECGECGKSFSRSSNLIKHQRI HTGERP YECSECGMRFQTSSH
LLQ--HYRI HT-EERP FCCPDCQKGFKRNSHLLRHQCI HT-GERPN ECG-----ECGKRF
SRNSHLTQHQRRH-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------YFHFGGEIDDDVQSDDDRSRVGAESPSPRSV
HSFCTSKG-------------------------------DWDWRGRSRETQFRDHWP-YT
RTSRKRLLQHDLSLPLMEKTNFEMEGEDDIDRDSMMDFESTSQDAESYQDV-VDLTEDRK
PQDPVQDNMENYRKLLSL--GVQLAEDDRHSHLTHGHSSRSKRSAYPST------SRGLK
TMPEAKKSTHRRGICEDRSSHGVIMEKFIKDVSRNSKVGKRG------------------
--------------SR--RMLDDDWKDVSFSKRES--VIQERGCEGSVLGG-GFNLSSNL
MSRKRVIERKRRYQLDTDGKGLVHNQKGYVRKKPFECSKM----RAAVSMSSL------S
SLSPTKSLPA-DFGDMPYVCDECGRPFSVISEFVEHQIMHTRENLSQY---GESFIHSMA
VSE--VQKRQL-HS----------------------------------------------
------------------------------------------------------------
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------ALKEHKIHSVPF
TESQKSHTI-TRPPDNEE--NERAFTISANPEEQQRFPTKESVCEGRRCERSVIHRLVFT
DPQKS-HSAAELSKPKVI---AESTI-SSADAIQC-QTAHAGESAYEGKVCGRSVIQSIV
TAEPPRHHTGNELAECS--NGESSIYISDFNR-QQKIDAR-ENPFEVAKYN----KY--T
VIHSVSSAEPQNSPTVEGPSELKKDGESSAPNSHVREYQKARAKKKYIECC--RDYKTSV
IHSL-PFGEPQN-------------------------------------------SVIR-
---SLALTDPQTSYAE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DC
MRMQCKECGKYFATSEALGRHQKVYGRERFH-GRTPFGSSVIRGVGFDESQ---------
-------------KDESDDTIYECKDCGLGFAHFNEFEDHQKV HG--REYLMDNRVCGPS
VIQTCSFGDSHKSGAGDQL YECPQCGESFISNDFLFEHQKM HEMEPFFV--GRQHNEAWM
RRLPLPTIRKRRRSSKKSP--PVSKT LRCQVCGQDFIHSSVLREHMKIHTGEDQLE--RG
KT---SEDTGA--------------------------------PGLRDHMRVHEK-DEPF
NYGATFVHTSFVSELPNTSSPFYECKDCGKSFIHSTILVKHQQL HLEE------------
------AAQEVEANFVVPQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPNLEAAEPNGEAE
GPDGGAAGPDGEAEQPS---GVAEPPRGD----ADEPDGAGIEDPEERAED-------PE
EDTDEPDGAGIEDPEEEGGDQEIQVEEPY YDCRECAKTFTSSSAYGEHLKT HARVIIYEA
GNVYGESSRYTEHASTS------------TSASDRA-DEKY FKCDVCGQLFRDRLSLARH
QNSHTG---------

MLSPKHLSATTPKKSWAPNLYELDSDLTKEPDVFFHQRFRNLI-------------YVEF
V--GPRKTLVKLRNLCLGWLQLETRTK-EIIELLVLEQYLTIIPEKLKPWVRA-------
----KKPENCEKLI---TLLENHKE----MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
HSFS-DR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFTESQPV-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGECSIYISDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFGRISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AREQAWNKFKEFRQFFATSKDLNTYQKIYEQE-----
------------------------------------------------------------
-------------------------------------KSHGKDEET--------------
------------------------------------------------------------
------------------------------------------------------------
----------H-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------DEETYGEETH-GQETIEGPVIQGSDM-------------
---------EDLQKDDPDNAIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSVSEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERLFECAICGEAFINPAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKEL HLEDDDDDDEAA-A--
---AAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAVEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

MLPPKSLSATKPK-KWAPNLYELDSDLS-EPDAVPGEGATDSEFFHQRF---RNFLYVEF
I--GPRKTLLKLRNLCLDWLQPEIRTKEEIIEVLVLEQYLSILPERIKPWVYA-------
----RKPETCEKLV---ALLEDYEA----MYEPEDDNSSDTHSEGGMSRRAAESPPPRPA
LPCCSD---------------------------------RERRRGRSRDMESRDRWP-SV
RSPRSRFHQRDLALPLAER---AKEREHRRRDSLLD-LDARSEEAVLYQDM-VALTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSARSKRSAYPST------SRGLK
TAPETKKSAHRRGICEAESSHGVIMEKFIKDVARSSRSGRARESSERP------------
------------HRLS--RRAGGDWKEASFSRREA--GASERGPEGGAFGGGGFSCGSDL
VSKKRALERKRRYHFDAEGQGPVHDPRGGARKRPFECGGEARRAAKAAGASSL------S
APPAAPSQPL-DFGAMPYVCDECGRSFAVISEFVEHQIVHTRESLYEY---GESFIHSAA
VSE--AQSRPE-GARRSEGA-------QAAGLAEHRGGQA-QEHLRGSG---DEEQDEPF
LPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHNH----EDREKERS-------------------------------TGAVR
RTPMLGELQRACGKEKRYECKVCGETFHHSAALREHQKTHGRGSPSEGRARAFEETFIPG
QSLKRRQKTYSKEKLYDFREGGDAFGRSSDF-MEHQKIHSRKSYFDSRGYEKPLLHSMSM
PGSQKSHTI-TRPPEDED--EEKAFTASSSPEDGQEAR----------------------
--------------------------------------------GYERSAYERAILHSLA
AFRPPRGL--------R-EDGEPSTYLSGLRDPPQKTPAW-ESPYAGGRHS----FFRSS
VFYRASRPAPLDHLAGEGPSGWQRDGEASGPSSDGRQHQKARAKKKNIER---KNYDASM
MHSL-HFGESQTFRPRERFYECLECGEFFVRSSELAEHQKIHNRKKLSGSKNYLRSVLR-
---SLSSTDPQTSYQGQSVQMSYPQEAAQTSYAELAAQTSY--AEEPAQTSYAVEPAQTS
YAEEPAQTSY--------------------------------------------------
----TEAPAEASYTEEPAQTSCIEEPAQTSYTNPAAETSYAEEPAQTSYTEAPAEASYTE
EPAQTSCIEEPAQTSYTNPAAETSYTEEPAQTSYTEAPAEASGIEEPAQTNYTEESAEVS
YTEEPSQTSCIEEPAQ--TSYTDPAAETSYTEEPAQTSYTQEPAQTSCTEEPAQTSCTEE
PAQTSYTQEPAQTSYTKEPAEASYTEEPAQTSCIEEPAQTNYTKESAKASYTEEPAQTTQ
TSYTDPAAETSYTEEPAQTNYTVESAEASYTEEPSQTSCIEEPAQTSYTDSAADTSCTEE
PAQTSCTEEPAQTSYTQEPAQTSCTEEPAQTSCTEEPAQTSYTQEPAQTSCTEEPAQTSY
TQEPAQTSCTEEPAQTSYTEEPAQTSYTEEPAQTSYTQEPAQTSYTQEPAQTSYTEEPAQ
TSYTEEPAQTSYAQEPAQTSYAEEPAQTSYAEEPAQTSYTQEPAQTNYTEEPAEASYTEE
PAQTSYAEEPAQTSYPEEPAQTSYAEEPAQTSYAEEPAQTSYPEEPAQTSYTEEPAQTSY
AKEPAQTSYPEEPAQTSYAEEPAQTSYAEEPAQTSYAEEPAQTSYSEEPAQTRYTNQLRS
DMRKNQLRPDMPRNQLRPVMPRNQLRPDMPRNQPRPVILRNQLRPDMPRNQPRPVILRNQ
LRPDMLGNQLRPDMPGNQLRP-DMLRPPAETSYAELVAQISYAELVTPTSYAELAAETGY
FEPPAQTSYTEPAETNYADPAAQVSFDEPPAEASYADLAAEISYAELAAETSYADLAAQI
SYDEPPAETSYAELAAQISYSEPADQTSYAELAAQTSYSEPLAQTSYAELTSETSYCEQP
VLNECKECGECFATVEDLGRHQKIYAREKFH-DGKLFGEPVMQDLGLDGSPEE-------
------ELEEQEEPEEPEDSIYGCKDCGLGFADRADLRDHQKVHG--REYLVDSREYTHP
AVHMPPVSEYQKDCLGEQLYECPACGESFVHSSFLFEHQKVHEQDQFYG--HRRY-EPFM
QPLIVS--PRRPQAPQKSA--PAGVGPQCQVCGQDFIHASVLSEHARGHAGEGLPD--QG
QG---GAGAAGPGPAPTEPQQDP--GEEQRYECETCGESFPSQADLQEHMRVHEK-GEPY
DYGAAFVHTSFLTEPPKRDWPFYECKDCGKSFIHSTILTKHQKLHLQEEGAAAA------
---AAATAQEAEANVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPLGEAE
GPEWEAAEPSGEAEQPH---AEAEQPDMD----ADEPDGAGIEDPEERAEE-------PE
GDDDEPDGAGIEDPEEEGEEQEIQVEEPYYDCGECGETFPSGAAYAEHLTAHASLVILEP
AGLYGEGAG--------------------GPEGGRP-DDELFKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHQEDDTNSDMTSDDDMSRSGRDTPPPQPS
HSFSSD----------------------R----------DQERRGRSRDVEPRDRWP-YT
RNPRSRLPQRDLSLPVMSRPHFGLERDDERRSM--D-YESRSQDAESYHNVVVELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRSAYPST------SRGLK
PMPEAKKPAHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARELNMR-------------
----------PPPRFP---RPSNNWKDTSSNKRES--VIQERAAEGSAFRG-GFRVNAEL
LSRSRALERKRRYHFDSEEKGSGHENKSCVRKKPFECGSEMRQ---ALSMGNL------S
CPPVPESPTIN-LAADPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VHE--VQKGQG-GGKRFECKECGETFSRSTALAQHRQVHA-REYLAECK---DQEDEDTI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGKSGANRENERERERERMRARAREQRER-ERERER-----EEHGEPFL
TCPNFGEFQDMHRKDRIYECKVCEESFFHLSSLKEHQKIHTRGNPFAKKSRMCEETFVPS
QSLRRRQKTY-REKLFDFNNARDALMESSDA-GDHQKIRSRKNFFESRAYEK------PF
TESQKSHTI-TRPPENKD--NDKPFTISSNPTDKLKFPTMANDCQGKAYERSAIHSFGPA
EAQKS-RGTLGFIKPRPVKSVTESST-QTTGDFSF-PQFFSRGSIFERKEYKGSVIHSLP
APRPLKRHRVNDQLECD-EGGESSIYISDLNNKRRKLPT-GEDTYEGSNSN----KHKEF
ILPRVPRTG-PPGLSGE-SRESNQDVIFSVPISSVREHQKARAKKKYLEPR---SNETSV
IHSL-PFGDLQAIRRRAKFFECQECGEAFARRSELIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FREFGQRSATSN-NLSVQKIYAQQ-----
------------------------------------------------------------
-------------------------------------KFYAEEPHAK-------------
ET---------------------------------HV-----------------------
------LKIHD-------------------------------------------------
-------KDPHG-----------------QEPHGQE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MRSEEPHGDKPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGQEPHDK--------------------------------
---------------------------------------EPLD---------------QE
------MSSEE---AQS----------SEPH-GQEKAEDTTIQASTS-------------
---------DEHQKDNANDMIYECQDCGLGFTDLTDLTSHQDVHS--RKALVDSREYAHS
EVHVHSVSEFEKKYSGEKLYECPKCGESFTHSSLLFEHQRVHEQDQLYS--VKAGDDGFV
AVLPV--RPRRNCASERNP-AVAGSAIRCRQCGQGFIHSSALNEHMRHHRDDE--MLEQN
EL---NDEVFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGEHHTKVHK-DEPY
EYGPSYTHASFLTEPRRKHIPLYECKDCGQPFLDNTVITEQLVFHPEREGGSDI------
---VAATAQEVEANTLIPQEVLRSQGSNAEAAEPEVEAAEPEVEAAEPEVEAAQPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERVNEPEEDVEEPE
GNADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECTETFASSAAFGEHLKSHASVIIFEP
ANALGECSGYIERASAST----------SSDGAEQA-DDKYFKCDVCGQLFDNRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHPEDD-NSDVTSDDDMTRNRRESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-HT
RNPRSRMPQRDLSLPVMAKTSFEMDRDDDRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDISLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPV-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RERERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGSTSGGREYSRSVIHSLV
ASKPPRSHSGNELVESN-EKGESSIYISDLNDKRQKLPAR-ENPCEGGSKN-H--NYEDS
VIQSVSRAKPQESVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFTHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKCKEFRQFFATRKDLNTNQKIYDQE-----
------------------------------------------------------------
-------------------------------------ESQGEKTHGE-------------
ET---------------------------------HS-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHGEETH-GQETIEDPVIQGSDM-------------
---------EDPQKNDPDNKIYECEDCGLGFVDLTDLTDHQKVHS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAIRCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAVIPGLALTEFQRSQ--TEERLFECVVCGESFVNPAELAD-HVTIHK-NEPY
EYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAA-AAA
AAAAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEPYYDCHECTETFTSSTAFGEHLKTHASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKYFKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G-QRWSQSSEL
GVPEQLH----------------------DGEKPHKC-SKCGKS---FTW----------
-RSDLILHQRT HTGERP YECGECGKSFSRSSNLIRHQRI HTGERP YKCSKCGKRFQTSSD
LLK--HYRV HR-EERP FCCPDCGKGFRQNSHLTTHRRIHT-GERPYECG-----ECGKS-
----------------------------FTYSYILIKHRRTHTGERPYECSKCGKGFQTS
SCLLKHYQIHREERPF----------------------------------RCPDCGKGFR
QNSTLIQHRRI HTGERP YECGECGKSFSQSS-----------------------------
-SLIKHQRT HTGERP YECSECGKRFKTSSHL-LKHYPVHTEER-----------------
------------PFCCSD--CGKGFR----------------------------------
---------------------------QNSHLLRH-QHIHTGERPYECPRCGKRFSQSSH
LTQHQRRHPKL-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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------------------------------------------------------------
---------------MSE--TLTVMEPPA-------------------------------
-----------------------------------SESGAFPAPRLEGLLGNPEG----S
CPP-------QEGGFR--GVTITHWKIQAGEAAR---VGS-------KSG-ESPVLSSNL
LLLQREL----------------------VEGEAHQC-EICGKS---FTF----------
-NSDLVRHQIS HAGEKP YRCEQCGKSFSQSSHLVEHQRVHTGERLYVCNMCGKDFIHYAD
LAE--HQRAHT-GGKPFRCMQCGRAFHHSSDLVRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLVRHYQT HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNQCGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGERL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKDCGKAFLQKAHL
TEHRKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKVHTEEKLYDCS-QFG------KDFSSA--------------------------P
NFKNN------QG-----------------------------------------------
VHQEGLPLSKTAMHVGEKSAGQGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDESSHRTTSD--KLTVMELPS-------------------------------
-----------------------------------PESEEVHEPRLGELLGNPEGQSLGS
SPP-------QDRGCK--QVTVTHWKIQTGKTAQ---VCT-------KSG-RNRILNSDL
LLLQREL----------------------IEREANPC-DICGKT---FTF----------
-NSDLVRHQIS HAGEKP YTCDQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKDFIHYAG
LIE--HQRVHS-GEKPFKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHSG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYERS-QYG------RDFNST--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKAPIHLGERSVDKGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHQEDDTNSDMTSDDDMSRSGRETPPPRPP
HSLSSD----------------------R----------DQERRGRSREVEPRDRWP-YT
RNARSRLPHRDLSLPVMSRPHFELDRDDDRRSM--D-YESRSQDAESYQNV-VDRKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRPKRSAYPST------SRGLK
PMPEAKKPAHRRGICEDESSHGVIMEKFIKDVSRSSKSARARELNER-------------
----------PPPRFP---RPSDNWKDSSSTKRES--VIQERVSEGSSFRG-GFRVNTEL
L-RNRAQERKRRYHFDSDEKGSGHEPRSCVRKKPFECGSEMRQ---AMSMGSP------N
CAPSTDAQPID-LGADPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQRGQG-GGKRFECKECGETFSRSAALAEHRQGHA-REYLAECK---DQEDEDAI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGNPG---DDERERERERMRARAREQRER-EREREREL--ERDPREPFL
TCPNFGEFRKMCRKEKIYECKVCGESFLHLSSLKEHQKIHTRANPFDNKNRVCEETFVPS
QALKRRQKTY-REKLFDFNNSREALMESAGP-GDHQKNRSRKNFFEGRAFEK------PF
TESQKSHTI-TRPPGNKD--EDKPFTISSNPNDKPKLPSMEHGGQGRPFQRSVIHSLGPA
EMRRI-RGVFT--KPRPL---VESST-QTPGTFSH-PRVLSGGNAYEGKEFKASVIHSMP
APRPLKRHRVNDQVECN-EGAESSIFISDLNNKRRKIPT-GDDTYKGSNGN-----SKDP
ILPSVPRAE-PPSLSGE-SRDSNQDVTFSVPSSSVREHQKARAKKKYIESR---SNATSV
IHSLGPFGDLQAIRRRPKIFECQECGEAFARRSELIEHQKIHDRERPSGSRLFERSVIR-
---SLAPADPQTSYAQERF----VQEQVRK-FRAFGQRSATSNNSLSVQKIYAQQ-----
------------------------------------------------------------
-------------------------------------KHYAEEPHAK-------------
ET----------------------------------------------------------
------QKIHD-------------------------------------------------
-------REPQG-----------------KQPHGQE------------------------
-----PHGDEPQDKEPLDQD----------------------------------------
----------------------MRSE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----ETQGDKPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPQDK--------------------------------
---------------------------------------EPVD---------------QE
------MRSEE---T----------QGDEPQ-GQAKVDDIPMQASSP-------------
---------EERQKDDASDTIYECQDCGLGFADLADLTSHQDVHS--RKSLVDSREYAHS
EVHVRSVSEFEKKYSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQLGS--AKAPDDGLV
AVMPA--RPRRNRAAEVNP-AVAGSAIRCRQCGQGFIHSSALNEHMRHHRDDE--AMEHG
EL---AEEIFMQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKRMPLYECKDCGHSFLDDTVVAERMVFHPERDGASDI------
---VAATAREVEANVLIPQEVLRVQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERVDEPEEEVEEPE
GDADEPDGADVGDPEEEGEDQEIEVEEPFYNCHECTETFATSAAFGEHLKSHASVIIFEP
ANAPGECSGYIERASTS------------AGGAEQA-DEKYFKCDVCGQVFHDRLSLARH
QNSHTG---------

MMPPKHLSATKSKKSWAPDLYELDSDLTKEPEAIIGEGATDPEFSHQRF---RNLVYVEF
V--GPRKTLIQLRNLCLDWLQPESRTKEEIIELLVLEQYLTILPERIKPWVQA-------
----KKPENCEKLV---TLLENYKE----MYEPEDDIR----GEDRRSRNRGETPPPRPV
YSFCG-----------------------G----------DRDRRGRSRDVESRDRWP-YA
RSSRSRMPPRDLSLPLMEKTTFEMEREDDDRDSVMD-YGSRSQDAESYQDV-VDLTEDRK
PQNPIQDNMENYRKLLSLGTGVQLAEDDGHSHMTQGHSSRSKRSATPAQ-------SSLK
SMPETKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRAREPNGRS------------
------------RRLP--RMSGGDWKEGSFNKRES--VIQERGYEGNAFGR-GFNFSSNL
VSKKRVLERKRRYQFDTDGKGSVLDQKGYARKKPFECNEM----RKAMSTSSL------G
APPSAEAQPA-DFAAVPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQA-GGKRFECKECGETFHKSAALSEHRKIHA-REYLSECK---DKECEEAF
MPSPT-----------------------------LSELQKMYGKEKFYECRVCKETFLHS
SALIDHHKIHGRGNFCDDKDNER--------------------------------GEAFK
PSPTLSEFQK------MYECKVCGETFLHSSSLKEHQKIHTRGNLFENKGKVCEETFV--
----------------EFKDGGDSFIQSSDL-GEHQKIHSRKNLYEGRGYEKSVIHSVPF
TESQKSHTI-TRPPENEE--SEKAFTISSNPEEHQKLPSVENIFEGKSSEQSAIHSSAFI
EPQKS-QSVVEADKPKVV---AESTI-QSSAMIGH-KKVHPRQNICDEKEYGISVIHSLA
APQSPKRHIANEVAECN-EKGESSIYISDLHY-QQKTPAR-DNSYDGGKKS----KFKDS
VKYSVSH-----------------------------------------------------
------------------------------------------------------------
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---------------

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--------------KPHKCSECGKGFRRRRELILHQRT HT-GERP YECG-----ECGKSF
SQSSS-----------------------------LIKHQRIHTGERPYQCSKCGKRFQSS
SCLLRHYRVHREERPF----------------------------------CCPDCGKGFR
ENSKLIRHRHIHTGERPYE-----------------------------------------
----------------------------------------------CSKCGKSFQTSSDL
LKHYRI HT-EERP FRCPD--CGKGFK----------------------------------
---------------------------RNSHLLSH-QRI HTGERP YECPQCGKRFRTSSN
LLRHERI HTEERP FRCP-DCG------MGFNRN--------------------------S
HLTRH------RR-----------------------------------------------
I HTGE------------RP YECGECGKRFLRNSHLTRHQQRH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MGTPA-------------------------------
-----------------------------------PESGGVSAPGLGGLLGNLEGQ---S
PPS-------REGGRK--PVTVTHWKIQTGEAVQ---VGR-------ACR-GGPVLSSDL
LLLQREL----------------------TEGEAHPC-GTCGQS---FPF----------
-TADLVRHQIS HTGEKP YRGDQCGKAFSQSSHLVEHQSV HTGERL YVCNACGKDFAHYAG
LIE--HQRA HA-GEKP FKCAQCGKGFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYDCS-QYG------KDFHSN--------------------------P
NFKNN------QG-----------------------------------------------
LTQEGLPLSKTPAHVGEKSVSQGGRTDD--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MLPPKYLSATKPKKSWAPDLYELDSDLTKEPDATVREGATDPEFFHQRF---RNFLYVEF
V--GPRKTLFKLRNLCLDWLQPETRTKEEIIELLVLEQYLTILPEKIKPWVRA-------
----KKPENCEKLV---TLLENYKG----MYEPGDD-NSDLRSEDSMSRKGAESPPPRSA
SSFC---------------------NWDR----------EREQRGRSRDLESRDRWP-YT
RNPRNRLPQRDLSLPLMEKTTFAMERERKRRDSVMD-YESRSQDAVSYQDV-VNLTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPST------SRGLK
TMPETKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARESNDRL------------
------------QRFP--RRPDNDWKEVSFNKRES--VIQERGYEGNAFGG-SYNFNSSL
VSKKRVLERKRRYQFDTDGKGSVHEQKGYSF-----------------------------
-------------------------------------------------------IHSVA
VS----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------EVQGRGYEKSVIHSVPF
TESQKSHTI-TRPPENEE--DEKAFTISCNPDDNQKIPTKENACERKPYERSVIHSLAFA
KAQKS-HSAVGPSKPQVI---AESTI-QSSGVTEH-QKVPAGENS-EGKKCERSVIHSLA
AFKPPKNCNGNEVIECD-EKGESSTYSSDLRDKQQKTPAR-ENPYEGAKSN----NYKDS
VIQSVSRIEPQKSLTSQGSS------ESSIPSSNVREHQKARAKKKNIER---RNYETSV
IHSM-RYS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EQP-------------------------------
------------------------------------------------------------
----------AQTSYA--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----KQPAQTSYAKQPAQTSYI------------------------------------AH
PVQ---------------------------------------------------------
------ISYSEHPMQLSYTKP-AQMSY-TKPAQMS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------YTEEQAQTSYAEQQ
VRNKCKECGECFATIEELGAHQKIYAREELH-GRKLFGNSVIQGVGLDGPRQVEPRQEEP
RQDEPDER---DEQDEPEDTIYGCKDCGLGFADRADLKDHQKVHG--REYLIDSREYTHS
VIHTHS----------------------------------IHEQDQFFG--HRRYDEPFM
QPLVIN--PRRPRAPQKNP--PAGTSLQCHVCGQDFIHGSVLSEHMRIHTGEDLPE--QG
QR---SEDAVSPGLALAEYYGA--------------------------------------
----------------------------------------------SFEEE---------
-----EGAQEVEANVLVPREVLRIQGSNVEAAEPEVEAAEPEVEVAEPNVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPEEEGEDQEIQVEEPYYDCRECGETFTSNSAYGEHLKT HARVIIFEP
GNVYGESSRYTEHASTS------------TSDNDRA-DDKY FKCDVCGQLFTDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MELTA-------------------------------
-----------------------------------PTSGRGPDPRLGRLLGNLDPQSLRS
CTS-------QEGGFQ--QVTVTHWKIQTAEGAQ---VGS-------KSE-GSPLLSPDL
LLLQREL----------------------IEGEAPQH-EACG-S---FPF----------
-NPGLARHQASHAGEKAHRCDECGKGFSQSSHLVEHHHAHGEERLYVCNACGKDFVLYTD
LME--HQKVHT-GERPFKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKAFIRS
SSLIRHFQV HTEVRQY----------------------------------ECQDCGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHSG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------KEFTPP--------------------------P
DFNSS------QE-----------------------------------------------
APQEGLPLSQTAVHLGETCGGLEGHT-DF-------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--KLTVLEPSV-------------------------------
-----------------------------------SEPGEFQEDRLVQLLGNPERKIIES
SPS-------QEGSLK--QMTVTRWKIQTGETAQ---MCS-------KSG-RNPTLNSNL
LILQREL----------------------IEGETHSC-GIGSKS---FSF----------
-NSNVVPHQISHTGEKPYQCDRCGKAFSQNSLLTEHQRV HTGDRL YVCNVCGKDFIHYTN
LVE--HQHV HT-DEKP FKCAQCGKAFCHSSDLLRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECHECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECDECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIV HTGEKP YVCSYCGKGFIQRSN
FLQHQKVHTEEKLYKYS-QHG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSIHLGERATDQECHADNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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---------------

MLPPKYLSATKPKKSWAPDLYELDSDLTKEPDATVREGATDPEFFHQRF---RNFLYVEF
V--GPRKTLFKLRNLCLDWLQPETRTKEEIIELLVLEQYLTILPEKIKPWVRA-------
----KNPENCEKLV---TLLENYKG----MYEPGDDNSSDLLSEDSISRKGAESPPPRSA
SSFCR-------------------LDWDR----------EREWRGRSRDLESRDRWP-YT
RNPRSRLPQRDLSLPLMEKTTFAMERERKRRDSVMD-YESGSQDAVSYQDV-VNLTEDRK
PQNPIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPST------SRGLK
TMPETKKSTHRRGICEDESSHGVIMEKFIKDVSRNSKSGRARDSNDRS------------
------------QRFP--RRPDNDWKEASFNKRES--VIQERGYEGNAFGG-SYNCNSSL
VSKKRVLERKRRYHFDTDGKGSIHEQKGCARKRPFECSEM----RKAMSMSSL------S
APSFTESHPL-DC---------------------------------------ESFIHSVA
VSE--VQK--------------------------------------------SQEYEEPF
MPSPT-----------------------------FSELQKIYGKDKFYECKVCKETFLHS
SALIEHQKTHGK----DDKDNER--------------------------------GEAFK
PSPPLNEVPKMYGKEKMYECKVCGETFHHSS-----------------------------
----------------------------------------------GRGYEKSVIHSVPF
TESQKSHTI-TRPPESEE--DEKAFTISSNPDDGQKIPAKENACERKPYERSVIHSVAFA
KAQKS-NSAVGPSKPQVI---AES-T-QSSGVTEH-QKVHAGENS-EGKKYERSVIHSLA
SFRPPKNCNGNEVVECD-EKGESSTHISDPRDKQQKTPAR-ENPYEGAKSN----NYKDS
VIQSVSRIEPPRSLTSQGSS------ESSVPSSSVREHQKARAKKKNIER---RNHETSV
IHSL-RFGQPHTFR-------------------------------------NYERSVIR-
---SLASTDPQTK-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------QAQTSYAEQQ
VRNKCKECGDCFATIEELGAHQKIYAREEFH-GRKLFGNSVIQGIGLDGPRQVESQPDDP
RQDDPDEQD---EQDETEDSIYGCKDCGLGFADRADLKDHQKVHG--REYLIDSREYTHS
VIHTHSVSEYQKDYIGEQLYECPACGESFVHSSFLFEHQKIHEQDQFFG--HRRYEEPFM
QPLVIN--PRRPRAPQKNP--PAGTSLQCHVCGQDFIHGSVLSEHMRIHTGEDLPE--QD
QR---SEDAVSPGLALTEFQRSQ--TEEKHYECKTCGESFLNQSDLTEHMRV HEK-DEPY
DYGTSFVHTSFLTEPPKRDSPF YECKDCGKSFIHNTVLTKHQKLHLEEEEE---------
-----EGAQEVEANVLVPQEVLRIQGSNVEAAEPEVEAVEPEVEAAEPNVEAAEPNGEAE
GPDGEAAEPNGEAEQPS---GEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPEEEGDDQEIQVEEPYYDCRECGETFTSNSAYGEHLKTHARVIIFEP
GSVYGESSRYTEHASTS------------TSDNDRA-DDKYFKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---EQLH----------------------DGEKPHKC-SECGKG---FRR----------
-RSELILHQRT HSGERP YECSKCGKSFSQSSHLIVHQRTHTGERPYECSKCGKRFQTSSC
LLR--HYRVHR-EERPFRCPDCGKGFRYNSTFITHRRI HT-GERP YECG-----ECGKRF
QTSSS-----------------------------LIVHQRIHTGERPYECSKCGKGFQTS
ACLLRHYRVHTKERPF----------------------------------CCPDCGKGFR
HNSTLIQHRRI HTGERP YECPRCGKRFSQSS-----------------------------
-HLTQHQRRHRRAKLH--------------------------------------------
------------------------------------------------------------
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---------------

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------------------------------------------------------------
-------QIHR-EERPFCCPDCGKGFRKNSHLTTHRRI HT-GERP YECS-----ECGKSF
SHSSH-----------------------------LIKHQRI HTGERP YECSECGKRFQTS
SNLLQHYRI HTEERPF----------------------------------RCPDCGKGFR
DNSTLIQHRRI HTGERP YECGECGKRFSQSS-----------------------------
-HLTKHQRRHR-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MPHPKHLCATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRF---RNLLYVEF
V--GPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVQA-------
----KKPENCEKLV---TLLENYTK----MYQPEDDTSSDINSDDDMNRNRGESPLPRTV
HSFS-NR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRNRLPQRDLSLPVIAKTSFEMERDDDRDLM--D-YESRSQDAESYQNV-VDLTEERK
PHNTIQDNMENYRKLLSL--GWSP------------------------------------
----SHTSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRL------------
------------QRFA--RMSDDNWKDISFNKRES--VIQERGYEGNAFRG-GFRFNSNP
VSRKRVLERKRRYHFDTDGKGSTHDQKGCPRKKPFECGSEMRK---AMSMSSLSSLGSLS
SPSFTESQPV-DLGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQT-GGKHFECKECGETFNKSAALAEHRKIHA-REYLAGCK---DQEYEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNE----------------------------RERERGEAFM
PSSTLNNFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKSKVCEETFIPS
QSLKRRQKSYTKEKLYDFKDGRDAFMQSSDI-SEHQKIHSRKNLFEGRGYEKSVIHSMPF
TESQKSHTI-TRPPENEE--DEKAFTISSNPDENQKFPTIENVCEGKPYERSVIHTLSSA
EAQKS-SSAGGSHKPKVI---AESTV-QSSDVINH-QKVRVGVSACEGREYKRSVIYSLA
SPKSLKSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-EKPYEGGKNN----SYEES
VIQSVSHAKPQKSLTGEGSGEIKKDGEFSVPSSNVREYQKARAKKKYIERR---SNETSV
IHSL-PFGEQQIVRSREKLYECEECGESFAYSSDLTEHRKIHDREKPSGSRNYERSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKCKEFRQCFDASRDLNTHQKINK-------
------------------------------------------------------------
--------------------------------------SHGKESNGE-------------
KI---------------------------------HG-----------------------
------------------------------------------------------------
-------EETHS-----------------KKTCGKE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------I----------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------RGE-------------------------------------
------------------------------------------------------------
---------------DGEESHDKKTHGEETH-GQEGIEDSVIQGSDV-------------
---------ED------------------------------------RKCLV--------
-------------------------DKSFIHSSFLFEHQRIHEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAIRCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERL FECAVCGESFVNASELAD-HISV HK-DEPY
EYGSSYTHTSFLVEPLKGAIPF YECKDCGKSFIHNTVLTKHKEL HLEEEDDDEEE-----
-EGAVAAAQEVEANFLVPQEVLRIQGSNMEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPQP-NGGAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPEEEGEDQEIEVEEPY YDCHECTETFTSSAAFSEHLKT HASMIVFEP
ANAFGECSGYIERAST------------STSGADHA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--RLTVMEHPT-------------------------------
-----------------------------------SESREVHEARLGQLLGNSEGQSLGS
PPS-------QEDGFK--QVTVTHWKIQTGETAQ---VCS-------KPG-RNPILNPNL
LILQREL----------------------VEGESHPC-GICGKS---FSF----------
-NSDLVKHQIS HTGQKP YKCEHCGKDFSQASHLVEHQRTHTEDRLYVCNVCGKDFIHYTN
LAE--HQQVHT-GEKPFRCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLVEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSFCGKGFIQRSN
FLQHQKMHTEEKLYECS-QLG------EDCTPP--------------------------P
DF----------------------------------------------------------
IHQEGLSLSETPTCLDERSTGQEGHMDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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--------------MMSD--RLSVMEHTT-------------------------------
-----------------------------------SESREVHETRLGQLLGNPEGQSLGS
PPS-------QDDGFK--QVTVTHWKIQTGETAQ---TCS-------KPG-RNPILNPNL
LILQREL----------------------IEGEAHPG-GICGKS---FPF----------
-SSDLVRHQISHTGEKPYKCEDCGKDFSQTSHLAEHQRAHTGNRLYVCNVCGKDFIHYTN
LAE--HQQVHT-GEKPFRCVQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKDCGKAFR
HRSDLVEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSFCGKGFIQRSN
FLQHQKMHTEERLYECS-QLE------EGCTPP--------------------------P
DF----------------------------------------------------------
IHQEGLSLSETPTCLGERSTGQEGHMDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDENSHRTTSD--RLTVMELPS-------------------------------
-----------------------------------PESEEVHEPRLGELLGNPEGQSLGS
SPS-------QDRGCK--QVTVTHWKIQTGETAQ---VCT-------KSG-RNRILNSDL
LLLQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHRIS HAGEKP YTCDQCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIHYSG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHSEEKLYECS-QYG------RDFNPT--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKAPIHLGERSVDKGEHTGNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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---EQ-------------------------------------------------------
------------------------------------------------------------
--------LHD-GEKPHKCSECGKSFRTRSELILHQRI HT-GERP YECG-----ECGKSF
SQSSS-----------------------------LIVHQRIHTGERPYECSKCGKRFQTS
SCLLRHYRVHMEERPF----------------------------------RCPDCGKGFR
DNSTLIQHRRI HTRERP YKCGECGKSFSRRS-----------------------------
-SLIQHQRTHTGERPYECSECGKGFQTSSHL-HQHYRVHTEER-----------------
------------PFRCPD--CGKGFR----------------------------------
---------------------------KNSHLLRH-QRI HTGERP YECPRCGKRFSRNSH
LTKHQRRHRGLIQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------MELTA-------------------------------
-----------------------------------PTSGRGPDPRLGRLLGNLDAQSLRS
CTS-------QEGGFQ--QVTVTHWKIQTAEGAQ---AGS-------KSE-GSPLLSPDL
LLLQREL----------------------IEGEAPQH-EACG-S---FPF----------
-NPGLARHQASHAGEKAHRCDECGKGFSQSSHLVEHHHA HGEERL YVCNVCGKDFVLYTD
LME--HQKV HT-GERP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKAFIRS
SSLIRHFQV HTEVRQY----------------------------------ECQDCGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------KEFTPP--------------------------P
DFNSS------QE-----------------------------------------------
ASQEGLPLSQTAVHLGETCGGLEGHT-DF-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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-------RIHREERPF----------------------------------CCPDCGKGFR
YNSTLIQHRRI HTGERP YECSECGKSFSQSS-----------------------------
-SLIMHQRIHTGERPYECSECGKRFQTTSHL-LKHYPVHTEER-----------------
------------PFCCPD--CGKGFR----------------------------------
---------------------------QNSHLLRH-QRI HTGERP YECPRCGKRFSQSSH
LTQHQRRH----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---EQLH----------------------DGEKPHKY-SECGKS---FSR----------
-SSSLIMHQRT HTGERP YECGECGKIFSQRSNLSRHQRI HTGERP YECSKCGKRFQTSSD
LLQ--HYRV HT-EERP FCCPDCGKGFRQNSTLIQHRRI HT-GERP YECG-----ECGKSF
SQSSH-----------------------------LIMHQRTHTGERPYECSKCGKRFQTS
ACLLRHYRIHTEERPF----------------------------------RCPDCGKGFR
QNSTLIQHRRI HTGERP YECPRCGKRFSQSS-----------------------------
-HLTQHQQRHRRAKLH--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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-----------------------------MYHHEDDTNSDMNSDDDMSRSGRETPPPRPS
HAFSSE----------------------R----------DLERRGRSRDVEPRDRWP-YT
RNPRSRMPQRDLSLPVMSRPHFGLERDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRTAYPST------SRGLK
PMPEAKKPSHRRGICEDESSHGVIMEKFIKDVSRNPRSGRARELNER-------------
----------PPPRFP---RPNDNWKDSSSNKRES--VIQERGYEGSSFRG-GFRFNADL
VSRSRALERKRRYHFDSEERGSGHEHKSCVRKKPFECGSEMRQ---AMSMGNL------R
NPSLSESQSVD-FGANQYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-RGKRFECKECGETFSRSAALAEHRQIHA-REYLAECR---DQEDEETV
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNSD-DRDNERERERDRLRARAREQRER-EREREREREREHEHGEPFL
TCPNFNEFRKMYRKEKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRVCEETFVPS
QSLKRRQKTY-REKLFDFNNARDALMGSSDP-SEHQKNRSRKNFFEGRGFEK------PF
VESQKSHTI-TRPPENRE--DDKPFTISVNPNDKLKFSAMESSSQGKSYERSVIHSLGSP
EAQKS-HGALGFSKPKSV---TESST-QTSSSINY-RRTHSGGITYEGKEYKGSIIHSLP
APRPLKRHRVSDQIQCD-EEGESSIYIPDIIK-RRKIPA-REDAYEGSSSS----SY---
HTASVPRAE-PPSVSGE-SRESKQDVTFSVPSSSVREHQKARAKKKYIEPR---SNETSV
IHSL-PFGEFLAGHRRAKFFECQECGEAFARRSDLIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FRAFGQRSTTSN-NLSVQKIYAQE-----
------------------------------------------------------------
-------------------------------------KFNAEEPHDK-------------
ET---------------------------------HG-----------------------
------QKIHD-------------------------------------------------
-------KEPYG-----------------KEPSGQD------------------------
-----PHGDEPQDKEPQDKE----------------------------------------
----------------------PQDKEPQ-----------------DKE-----------
-----------------------------------------------P---------QDK
EPQ----DKEPQDKEPQ-------------------------------------------
------------------------------------------------------------
----------------------DKQPQDKEPQD----KEP-----------------LDQ
EMRSEEPHGDQPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPHDK--------------------------------
---------------------------------------EPVD---------------QE
------MPSEE---PQG----------EESH-GQEKAEDITIETSVS-------------
---------EEPQKDDAGDAIYECQDCGLGFADLNDLTSHQDVHS--RKSLVDSREYTHS
EVHVHSVSEFEKKYSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQTYS--VKACDDGFI
ALLPA--RPRRNCTVERNP-AVSGSAIRCRQCGQGFIHSSALNEHMRQHRDNE--ILEQN
EL---ADEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVITERMVFHPEREGGSEI------
---VAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECAETFASSAAFGEHLKSHASVIIFEP
ANALGECSGYIERASTS------------AGGAEQAD-DKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--KFTVLEPSA-------------------------------
-----------------------------------SESREFHEDRLAQLLGNPEKQSLES
PSS-------QDGSFT--QMTVTHWKIQTGDTAQ---RCS-------KSG-RNPILNSNL
LILQREL----------------------IEGEAHSY-GVGGKN---FPL----------
-NSDVVPHQISHTGEKPYKCDHCGKGFSQASLLTEHQRVHTGDRLYVCNVCGKDFVHYAN
LRE--HQHVHT-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECQECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHSGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKMHTEEKLYKYS-QLG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSENSVHLGERSTDRECCGDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MFSTQASSGQSGG-SGG------RREFPSVGGAGVGEKGDPVSQLRGGVREGRSHLSVGG
IGNGRRREVLSL--------------------------------RDGGGWSQG-------
----RVEEAAISLY---LL-----------------STDDANSNGDMRWNRGGTPPARPS
DS---PGDRDRD--------------RDG----------DWDRRGRSRDVEPRDRWA-HS
RSPRGRLPHRDLSLPVMARASFQMEREEDGVSM--D-YESRSQDAESYRSV-MEASEDRK
SQNPIQDNMENYRKLLSL--GVQLAEDDRHSHMTQGHSSRAKRSAYPS--T----SRGLK
TMPEAKKPSHRRGICEDESSHGVIMEKFIKDAAHGSRSGRAREPNDRL------------
------------QRFP--RVPDDHWRDSSLNRREP--LAPQRGFEGSAFRG-GFRFNPNL
ISRRRALERKRRYHFDTEGKSGAHEHKGSARKKPFECGSEMRR---ATGTSSLAS-----
-ASSSESQPS-DLGATSYVCDECGRSFTVISEFVEHQIMHTRENLYEY---GESFVQSST
PNEGPSQSHQS-GGKRFECRECGEVFTKSAALAEHRRIHA-REYLAECK---DQESEEQA
LPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKVHEVGSCGGDEASERD--------------------------HEPGRGAAFM
PGAALREFQKMYGKNKIYECKG---------------------------------AFTPS
SSLKRRQKTYTKEKFFDVKDGRDPFMQNADL-SEQQKIHSRKNFFNGRGYEKSAVHSMPF
TESQKSHTI-TRPPEDEE--EEKAFTISSNPDEAQTPPTKENAYEGKFYEKSNTHCLGSA
EAQKS-V--SGFTKPAVP---AMPAT-HSSEVPNY-MKACFGENSSAGKEYLASITRSLA
IPRSLKRYYVNKEAGCD-EKGESSTYLSDLHNKRRKIPAR-ESPYDGDSN-----DYRDA
TMPSTSYAEPQRSLAGDRAREFKQDGVFSVPTTSVRSHQKARAKKKYIE--------PTV
YHSL-PFGELPIVRPREKLYECQECGESFYRSSDLIEHQKIHDREKPSGSGHYEQSINH-
---SMTTTSPQTSYTQEQY----AEEQVHDKSNKS----ATNNSLLVQWAICTQE-----
------------------------------------------------------------
-------------------------------------KTPGEGTYAE-------------
KT---------------------------------QG-----------------------
------QTQEQKIDSQE-TQ----------------------------------------
------EQKMDG-----------------QEAQEQK------------------------
-----MDSHEIQDQKMDSQE----------------------------------------
----------------------IQDEEID-----------------GQEIQDQKMDD---
----------------------------Q-----------------EI---------QDQ
EID----VQEIYVQESQ-------------------------------------------
------------------------------------------------------------
----------------------DQEIDVQEIQD----QEI-----------------DIQ
EIQDQKMDAQETQS----------------------------------------------
------------------------------------------------------------
-----------------QEM----------------------------------------
---------------------------------------------DAQETHG------ED
------TCDQG---INSEESQGQEMDDQESQ-DQETGEDTISQVS-S-------------
---------SDEQKDEPEDTIYECQECGLGFVYLTDLTSHQDVHS--RKCLVDSREYALS
DVHMHSLSEYQKECAGEQLFECPKCGESFIHSSFLFEHQRVHEQDQLYS--VKGCDDGFI
CLLPV--KSRRSRAAERNP-A----------CGQGFIHSSALNEHLRHHRDEE--FLEQT
EA---GEEIFIQTLALTEFQDEE--DD---------------------------------
--------------------------------------------------DEEE------
----------------------------EEEEAPEVEAAEPEVEAAEPDVEAAEPDGEAE
GPDGEAAEADGEAEQPN---GGAEYPIGD----ADEPDGVGIEDPEERVEE-------PE
GDADEPDAAGIEDPEEEGEEQ----ERPYYNCQECTETFASSAAFREHLRAHASLVLP--
SNAPGEGAG--------------------PSAAQWV-DHQYFRCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDENSHRTMSD--KVTAMELPS-------------------------------
-----------------------------------PESGEVCEPRLEELLGNPEGQSLES
FPS-------QDRGCK--QVTVTRWKIQTRETAQ---VCT-------KSS-RRPVLNSDL
LILQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHQIL HAGKKP YTCDQCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIRYAG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NQCGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNSA--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKASVHLGERSAEQGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--KTWIAGNAYLHRMTSE--KLLVMEPSG-------------------------------
-----------------------------------PESGEVHEPRLGGLLGNPEGQSLRH
SPS-------REGGFR--QVRVTHWKIQPGEPAP---MCN-------KSG-RNPVLSSSL
LLLQREL----------------------GEGDAHQC-DACGKS---FTF----------
-NSDLLRHQISHTGEKPYKSDQCGKGFTQSSHLSEHQRIHTGERLYVCNVCGKDFIHYSS
LID--HQRVHT-GDKPFKCSHCAKAFCHSSDLIRHQRVHT-RERPYECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHTG-ERPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSHCGKGFIQRSN
FIQHQKIHAEEKLYECS-QYG------KGFSST--------------------------P
NFKNN------PG-----------------------------------------------
VHQEGRGLNKAPRHLGENSTGQEERSDN--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MLPPKYLSATKPKKSWAPNLYELDSDLDKEPDVIIGEGPTDSEFFHQRF---RNLIYVEF
V--GPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQFLTIIPEKLKPWVRA-------
----KKPENCEKLV---NLLENYKE----MYQPEDDTNSDVTSDEDMNRDGRESPQPRAG
RSFSD-----RE--------------HNR----------DWARRGRSRDAEPRGRWS-FP
RNPRSRLPQRDLSLPVTAKTSFAAERDDSRDSM--D-YESRSQDAESYQNV-VDLAEDRK
PHNTVQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSACPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFVKDG---SKSGRAREPSDRS------------
------------QRFP--RASDDNWKDVSLNRRES--VIQERGYEGNAFRG-GFRFNSNL
VSRRRVIDRKRRYHFDTDEKGSSHDQKGCARKKPFECGSEMRK---AMSMSGL------S
APSLTESPPAIDFAAMAYVCDECGRSFGVISEFVEHQIMHTRENLYEY---GESFVHSVA
VSE--VQRSQA-GGKRFECKECGETFGKSAAVAEHRETHA-RERLADAE---DPECEETF
MPSPT-----------------------------YAELQKMYGKDKFYACRVCKETFLHS
SALIEHQKVH----FGDDKDHERDRERE----------------------CERER-ESFT
PSSAFEEFQKMCGKEKVYECKVCGETFLHSSSLREHQKIHARGNPFENN----------G
QPLKRRQKTYGKEKPYDFSDGRDAFMPSSDF-SERQKIHSRKNLFEGRGYEKSVIHSVPA
TESPKSHTI-TRPPENE---EEKAFTISSNPNENQKFPTQENACEGKPYERSVIHSLASA
EAQKS-HSAVGPVKPKVI---AESTV-RSSDVSNH-QKVRAGGNTCEGMAYKRSVIHSLA
APKPLKIHDGNEVLECN-EQGECSIYISDLNDKQQKILAR-EKPYEGGKNN----NSEDS
AVQSVSRATPQKSLTGEGSGEVKKDGEFSVPSSNVRTYQKARAKKKYIEHR---SNETSV
IHSL-PFGKQHMVRPREKLYECQECGESFAYSYDLTEHQKIHDREKPSGSRTYELSVIR-
---SLAPTDPQTSYAQEQY----AKEQARIKSMEFRQLFAASKELNTHHKTYAQE-----
------------------------------------------------------------
-------------------------------------KSHGEETQGK-------------
DT---------------------------------HG-----------------------
------------------------------------------------------------
-------KKTHG-----------------EETHGEK------------------------
-----THGEET-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------HG-
------------------------------------------------------------
------------------------------------------------------------
-----------------KDTHGEETRDE--------------------------------
---------------------------------------ETQGK----------------
---------------ETCEAHGEETHVEEIH-GQEVVEDSVIQGSDL-------------
---------AEPQQEDPDDTIYECQDCGLGFVDLSDLTDHQQVHK---------------
-----------------QLYECPK--------------------YQLYS--LKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAIRCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEVIIPGLALTEFQRSQ--TEERLFECAICGESFYDAAELAD-HVSVHK-NEPY
EYGSAYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKEL HLEEDEEEEAAA----
-AAAAAAAQEVEVNVLVPREVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPEEEGEDQEIEVEEP YYDCQECPETFTSGAAFGEHLRA HASMIIFEP
ASAFGECSGYIERAGT------------STGAADRA-DEKY FKCDVCGQLFSDLLSLARH
QNTHTG---------

MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEFFHQRF---RNLIYVEF
V--GPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKLKPWVRA-------
----KKPENCEKLV---TLLENYKE----MYQPEDDNNSDVTSDDDMTRNRRESSPPHSV
HSFS-DR--------------------------------DWDRRGRSRDMEPRDRWS-HT
RNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDISLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AMSVSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNEREHERE----------------------RERERGETFR
PSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLCDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPRSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-ENPCEGGSKN-R--NYEDS
VIQSVFRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKCKDFRQFFATSEDLNTNQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGEESQGE-------------
NT---------------------------------DG-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHSEETH-GQETIEDPVIQGSDM-------------
---------EDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEER LFECAVCGESFVNPAELAD-HV TVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEEE-DEAA-A--
--AAAAAAQEVEANVHVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAGQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEPY YDCHECTETFTSSTAFSEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHQEDDTNSDMTSDDDMSRCGRETPPPRSS
HSLSSD----------------------R----------DQERRGRSREVEPRDRWP-YI
RSPRSRLPHRDLSLPVMSRPHFGLERDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRSAYPST------SRGLK
PMPEAKKPAHRRGICEDESSHGVIMEKFIKDVSRKS--ARARELHERP--------P--P
PP--------PPPRFP---RPSDNWKDGASNRRES--VIQERGPEGRAYRG-GFRFNADL
LSRNRVLERKRRYHFDSDER--GHEHKSCVRKKPFECGSEMRQ---AMSMGNL------S
CPPVPESQPID-FPADPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGRRFECKECGETFSRSAALAEHRQIHA-REYLAECN---DQENEDTI
MPSPT-----------------------------FSELQKIYGKDKFYECKVCKETFLHS
SALIEHQKTHGRGNSD-DRENERERERQRMRARARELRER-----------ERERGEPFL
TCPNFNEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRMCEETFVPS
QSLRRRQKTY-REKLFDFNNARDALMESSDP-GDHQKNRSRKNFFEGRGYEK------PF
AESQKSHTI-TRPPTN-E--DDKPFTISVNPNDKPKSPTMENGSQGRPYERPVIHSLGPA
LPLKS-RGAFGFPKPRSV---TESST-QTTGGI-L-PRILSRGSIFEGKEFKRSIIHSLP
APRPLKRHRANDLLGCD-EEGESSIYIPELSNKRRKIPT-GEDTYEGSNSS----NHTDS
IPPGVPRAE-PPSLSGE-PRESNQDVTFSVPSSSVREHQKARAKKKYIETR---SSEASL
IHSL-PFGDLQAFRRRAKFFECQECGEAFAHGSDLIEHQKIHDRERPSGSRHFERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FREFGQRSATSN-NLSVQKTHTQE-----
------------------------------------------------------------
-------------------------------------KY-AEEPHDK-------------
QT---------------------------------HG-----------------------
------QKIHD-------------------------------------------------
-------KEPNG-----------------QEPHGQE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
----------------------MQP---H-----------------GD------------
------------------------------------------------------------
--------------KPN-------------------------------------------
------------------------------------------------------------
----------------------GQEPLDQEMRN----EEP-----------------LDQ
EMRNEEPHGDKPNG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPHDN--------------------------------
---------------------------------------GPLD---------------QE
------MGGEE-------------PHGEESH-GQNKAEDATIQASGS-------------
---------EDHKKDDAGDMIYECQDCGLGFTDLTDLTSHQDVHS--RKDLVDSREYAPS
EVHAHPVSEFENKCSGEKLYECPKCGESFTHSSLLLEHQRVHEQDQLYS--VKACDDGFI
ALLPVT-RPRRNRAAERNPAAVTGSAIRCRQCGQGFIHSSALNEHMRQHRDDE--MLEQN
EL---TEEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQPFLDDTVIAERMVFHPEREGGSDI------
---VAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPELEAAEPNGEAE
GPDGEAAEPDGEAEQPN---AEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPDGADIEDPEEEGEDEEIEVEEPYYNCHECTETFASSAAFGEHLKSHASVIIFEP
ANALGESPGYPERASTS------------AGGAEQADDDKYFKCDVCGQLFQDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHHEDDTNSDMNSDDDMSRSGRETPPPRPS
HAFGSE----------------------R----------DLERRGRSRDVEPRDRWP-YT
RNPRSRLPQRDLSLPVMSRPHFGLDRDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRTAYPST------SRGLK
PMPEAKKPSHRRGICEDESSHGVIMEKFIKDVSRNPRSGRARELNER-------------
----------PPPRFP---RPNDNWKDSSSSRRES--VIQERGYEGSAFRG-GFRFNADL
ASRSRALERKRRYHFDSDERGSGHEHKSCVRKKPFECGTEMRQ---AMSMGNL------S
SPSFSESQSID-FGANPYVCDECGRQFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGKRFECKECGETFSRSAALAEHRQIHA-REYLAECR---DQEDEETI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNSD-DRDNERERERDRLRARAREQRER-ERER----ERERELGEPFL
TCPNFNEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRMCEETFVPS
QSFRRRQKTY-REKLFDFNNARDALMGSSDP-SEHQKNRSRRNFFEGRGFEK------PF
VESQKSHTI-TRPPGNKD--DDKPFTISVNPNDKLKFPIMENGSQGKSYERSVIHSLGSA
EAQKS-HGGLGFSKPRPV---AESST-QSSSSINY-PRAYPGGSTFEGKEYKDSIIHSLP
APRPLKRHRANDHIQCD-EEGESSIYIPDIINKRRKIPA-REDAYEGSSSS----SY---
HTPNVSRAE-PPSLSGE-SRDSKQDVTFSVPSSSVREHQKARAKKKYIEPR---NNETSV
IHSL-PFGELLAGHRRAKFFECQECGEAFARRSELIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FRAFGQRSTTSN-NLSVQKTYAQE-----
------------------------------------------------------------
-------------------------------------TFNAEEPHDK-------------
ET---------------------------------HG-----------------------
------QKIHD-------------------------------------------------
-------KEPYG-----------------KEPSGKE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
----------------------MRSEEPH-----------------DDK-----------
-----------------------------------------------P---------HGQ
EPH----G----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------DEPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHSDEPHDK--------------------------------
---------------------------------------EPID---------------QE
------MCSEE---PHSEESHGDELHGEESH-GQEKVEDATIQASVS-------------
---------EEHQKDDAGDAIYECQDCGLGFTDLNDLTSHQDTHS--RKALVDSREYAHS
EVHVHSVSEFEKKYSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQLYS--VKACDDGFI
ALLPV--RPRRNCTVERNP-AVSGSAIRCRQCGQGFIHSSALNEHMRQHRDNE--IMEQS
EL---ADEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEI------
---VAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPNGAVIEDPEEEGEDQEIEVEEPYYNCHECAETFASSSAFGEHLKSHASVIIFEP
ANAPGECSGYIERASTS------------AGGAEQVD-DKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YKSRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSSHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESTI-QSFDAINY-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGECSIYILDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFHPRGMLYECQECGECFARISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDLNTYQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKESQGE-------------
KI---------------------------------RG-----------------------
------------------------------------------------------------
-------EETY-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------SEETHGEMYGEETH-GQETIEDPVIQGSDM-------------
---------EDLQNDDPDNAIYECEDCGLGFVDLTELTDHQKV HS--RKCLVDSREYTHS
VIHTHSVSEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERLFECAICGEAFINPAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKEL HLEDDDDDDEAA----
--AAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MF----------
-NSDLVRHQISHTGEKPYKCDQCGKGFGQSSHLTEHQRVHTRERLYVCNACGKDFTHYPR
LLE--HQQVHA-GEKPFRCSQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QHG------ENFNST--------------------------P
DSKNN------EG-----------------------------------------------
VHPEGLALNKAPIHLGERPVGQGEHTDKL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----ISEDGNLQETVSE--TLTVMEPPT-------------------------------
-----------------------------------PESGRCPELRLGGLLGNLEGQSLQR
TPS-------QERGFK--QVTVTHWKIQTGEAAQ---VGT-------KSG-GSPVLSSNL
LILEREL----------------------VEGEAHPC-ETCSKS---FPF----------
-NSDLVGHQLSHTGDKLYKCDQCGRGFSQSSHLAEHQRVHTGERLYVCNVCGKDFVHYAD
LTE--HESIHA-GEKPFKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-EYG------KDFNST--------------------------P
NFKNN------QG-----------------------------------------------
IHQEGLPLSKTPIYLGENSVGQGEHTNNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--KLTVLEPSV-------------------------------
-----------------------------------SEPGEFQEDRLVQLLGNPERKIIES
SPS-------QEGSLK--QMTVTRWKIQTGETAQ---MCS-------KSG-RNPTLNSNL
LILQREL----------------------IEGETHSC-GIGSKS---FSF----------
-NSNVVPHQISHTGEKPYQCDRCGKAFSQNSLLTEHQRVHTGDRLYVCNVCGKDFIHYTN
LVE--HQHVHT-DEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECHECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECDECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKVHTEEKLYKYS-QHG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSIHLGERATDQECHADNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDENSHRTMSD--KVTAVELPS-------------------------------
-----------------------------------PESGEVCEPRLEELLGNPEGESLGS
SPS-------QDRGCK--QVTVTHWKIQTRETAQ---VCT-------KSG-RHPVLNSDF
LILQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHRTL HAGEKP YTCDQCGKGFGQSSHLMEHQSI HTGERL YVCNVCGKDFIRYAG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NQCGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNSA--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKASIRLGERSVDQGEHTGNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MMEPPA-------------------------------
-----------------------------------SESGAFPEPRLGGLLGNPERQNLRS
CSP-------QEGSFR--GVTVTHWKIQAGDAAR---ASS-------KSG-EGPVLSSNL
LLLQRDL----------------------VEGEAHHC-ETCGKS---FTF----------
-NSDLVRHQIS HAGEKH YRCEQCGKSFSQSSHLAEHQRA HTGERL YVCNMCGKDFIHYAD
LAE--HQRA HA-GGKPFRCMQCGRAFHHSS DLVRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRIHTGERPYECNECGKS FIRS
SS LIRHYQIHTEVKQY----------------------------------ECKECGKAFR
HRSD LIEHQRIHTGERPFECNECGKA FIRSSKLI QHQRIHTGERPYVC--NECGKRF SQT
S NFTQHQRIHTGEKLYECNECGKA FFLSSYL -IRHQKIHTGERVYECKECGKAF LQKA HL
TEHQKIHTG-DRPFECKD--CGKA FI----------------------------------
---------------------------QSSK LLLH-QIIHTGEKPYVCSYCGKG FIQRS N
FLQHQKIHTEEKLYECS-QYG------KDFTST--------------------------P
NFKNN------QG-----------------------------------------------
VHQEGLPLSKTPIHLGEKSASQGEHTDNIK------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MTQGHSSRSKRSAYPST------SRGLK
PTPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRAREGNDRP------------
------------PRFP--RVPNDNWKDTSSNKRES--VVQERASEGSTPRG-TFRFNPEL
MSRNRGLDRKRRYHFDSDDKGSGQDHKNCVRKKPFECGSEMRQ---AMSMGNL------T
CPPVADPQTIE-FPADPYVCDECGRTFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--GQKGQG-GGKRFECKECGETFNKSAALAEHRRIHA-REHLAECK---DPEEEDAV
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLYS
SALIEHQKIHRREERE-------ERERERA--RARAQ-------RERERERERELGEPFM
TCSSFSEFRKMYGKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENK-RMCEETFIPS
QSLKRRQKSY-KEKPFEFNNGRDGLMESSDL-SEHQKIRSRKNFFEGRRYEK------PF
PESQKSHTI-TRPPGNTE--DEKAFTISSNPNDKQKFPTMEN-----AYERPAICSLRPV
EPPKS-QGAVGFSKPKVK---AESST-QSSSGISHPPEVHSGGNSNEGKEYKGSIIHSPA
TPRPLKRHRGNDQIECG-DEGESSVYISDLN-KRRKIPTRESAH-EES-----KNNYKDS
TTPSASHAE-PQSLPVEASGKSKEDVKFSVPSSSVREHQKARAKKKYIEPNETKSNETSV
IQSL-FFRELYAIRQRAKLFECQECGETFVHRSDLIEHQKIHDRERPSGSRHYERSVIC-
---SLAPTDPQTSYAQERY----AEEQARK-FQEFGQHSTS--NSPSVQKIYVQE-----
------------------------------------------------------------
-------------------------------------KVHSEEFHAM-------------
ET---------------------------------SV-----------------------
------QGSLG-------------------------------------------------
-------QESHA-----------------METSVQE------------------------
-----SHTEESHAMETSVQE----------------------------------------
----------------------SHTEESH-----------------AME-----------
-----------------------------------------------I---------SVQ
ESH----TEESHAMETN-------------------------------------------
------------------------------------------------------------
----------------------VQESHTEEFHA----MET-----------------NDQ
ETNSQETNGQ--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
------IHGEE---PHGDGPHGEEPHGEGLH-GQEKPEDATPQASGS-------------
---------NEHQKD---DTIYECQECGLGFADLTDLTSHQNVHS--RKSLVDSREYERS
EDHVHSVSEFEKKYSGEKLYECSKCGESFIHSSFLFEHQRVHEEEQLYS--VKGCDDGFI
VLLPV--RPSRNHAQDTDP-AVAGSAIRCRQCGQGFIHSSALNEHMRHHRDDE--LLEQS
EL---AEEIFIHSLALTEYQGSEAETEEKLFECTICGECFFTAKQLGDHHSRVHK-DEPY
EYGPAYTHASFLTEPLRKHIPLYECKDCGQPFVDDTVITEHVVFHTD-DGEEEI------
---VTATAQEVEANVLIPQEVLRVQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GAEGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGFEDPEERAEEPEDDVEEPE
GDADEPDGAGIDDPEEEGEDQEIEVEEPYYNCHECTGTFASSAAFGEHLKTHASVIIFEP
ANALGECSGYIERASTS------------AGGADQA-DDKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SQ-------------------------------
----------------------------------SSELGVR--E------QLHDGEKSHR
CSE-------CGKSFRWSSDLIRHQRT HTGERPY---ECG-------ECG-KSFSRSSDL
IVHQRT H----------------------TGERP YEC-GECGKS---FSR----------
-RSHLIMHQRI HTGEKP YECGECGKSFSRSSSLIKHQGIHTGERPYECSECGKRFQTSSC
LLL--HYPVHK-EERPFCCPDCGKGFRKNSNLTTHRRI HT-GERP YECG-----KCGKGF
SHSSS-----------------------------LIKHQRI HTGERP YECSKCGKRFQTI
SDLLKHYRVHTEERPF----------------------------------CCPVCGKGFR
ENSTLIRHRRIHTGERPYECPRCGKRFSHSSNLTKHQRR HQEK-P HKC--LECGKGFSRN
DHLIEHQRI HTGERP YECGECGKRFRTSSDL-LKHERSHTEER-----------------
------------PFRCPD--CGNGFK----------------------------------
---------------------------LNSHLTVH-RRIHTGERPYECSECGKSFAESSV
FTKHQR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MMPIKRFYCGRAKKCWVPDLYDLDNDLAQYPDDIVGGSPTDSEFSHQRF---RNFLYVEV
V--GPQTTLLRLRNLCLDWLQPEIHSKEEIIDLLVLEQYLNILPERVRLWVQA-------
----RRPQTCEKLV---DLLEMYHE----VYGPEGDRDRDWD------------------
--QDWDRDRTWDRAWDRAWDRAWDRAWDRGRAWERARMRERERRARSRDLSLRDRWP-YG
RIPRNRFPPRDLSLPASMERAFSVDRGRRRRSLLMQ-YELQSQDTMSYQDM-VKLTEDRK
AQNSIKDNMENYRKLLFL--GLQLAEDDGHSHMTQGHS-RSKRSAYPST------SRGLR
TMPEAKKSTQRRGICEEEASHGAIMEKF-KDVLRNPKSARARVPSDRF------------
------------PRVP--RRADPDWKEGSLD-RES--VIQERGCAENACQG-ACNCNSNL
VSQKKVLERKRRYQFDTDGKGSAHDQRGSPLKRPFEGSEM----RKAMSMSSL------N
PPS-AESQPL-DFAA--------------------------------------TFIRSVA
VTR--KS-----------------------------------------------------
------------------------------------------------------------
----AAKKMHGR----DDK----D-------------------------------DEVFK
PNPAFKGLQ-----------------------------------MLENKSKVCEETFILG
QPIKRRQRYYFQDKLAGFKDDGSPFGQSLLFPSGHPSGHFQKNPYEGRAYGKSVIHSRPF
TESRKSHTI-TRPPENE---DEKAFTISSNPDDNQKVSTEENVLEKKPNERSVIHSLSLA
EVQKY-HSAVGPTKPKVI---AESTI--TSPNITE-QQVHAGEKTSEEKKNERSVIHSLA
VFKLPKNPSGNEWNEKG--------GFPNLHAKQQKPPAR-PTPNEGDKSN----NYKDS
VIRRVSGTEPPKSLAAEGASEFKKDGQSTVSKSDVPDGQKARAKKKNIER---RNCETSV
IHSL-HFGEPETEPVGMI------C-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------IQQPAQAS----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------HPRQPVGMSYAGQPAQASHPRQPVGVS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------YAGQPAQASCAQRP
TPQECQDCGQCFATIEDLGAHQKIYTQEEFH------GGSVIRGAGRGGPEQEEPE----
--------PEEEEEEDPEDSIYGCKDCGLGFADRADLKDHQKV HG--REYLVDTREYTQS
VIHTHSISEYQRDNTGEQL FECPACGESFVHSSFLFEHQKV HEQDPYYG--QRRYDEPFM
NPFIIN--PQRFRAPQANP---TGMY LQCHVCGQDFIHGSVFNEHLAL HMGEGSLE--QA
QR---SNDTVNAGLALAELQRSQ--AEEKH YECGTCGEAFLSQADLREHKKI HEKDDEPY
DYGASFVHTSFLTEPPKGDSPF FECKDCGKSFIHNTVLTKHQKF HVEEEE----------
-----AAAQEVEANVLVPREVLRIQGSNMEAAEPEVEAAEPEVEAAEPNVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEEREEELEGKAEEPE
GDADEPDGAGIEDPEEEDEDEEIQVEEPY YDCRECGETFTTTSAYGEHRQT HARVIIFES
GNVHGEGSHYTGQASTS------------TQGSEGA-DDKY FKCDVCGQFFHDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--KLTVLEPSA-------------------------------
-----------------------------------SEPREFHEDRLAPLLGNPERQNLES
PPS-------QEGGFK--QMTVTHWKIQTGETAQ---LCS-------KSG-RNPVLNSNL
LILQREL----------------------IEGEARSC-GVGGRS---FPF----------
-NSNVVPHPISHTGEKPYQCDHCGKGFSQNSLLTEHQRVHAGDRLSVCNVCGKDLIHYAD
LVE--HQRGHS-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECHECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKTHTKEKLLQYG-QHG------TDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSLHLGEASTDQGCHAGHL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--ELTVLEPSA-------------------------------
-----------------------------------SESREFHEDRLAQLLGNPDKQSLES
PSS-------QDGGFT--QMTVTHWKIQTGDTAQ---TCS-------KSG-RNPILNSNL
LILQREL----------------------IDAEARSC-GGGGKG---FPF----------
-NSDVVPHQISHTGEKPYKCDHCGKGFSQTSLLTEHQRVHTGDRLCVCHVCGKDFVHYAS
LRE--HQHVHT-GEKPFKCAQCGKAFCHSSDLLRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECQECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HSGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HTG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIV HTGEKP YVCSYCGKGFIQRSN
FLQHQKMHTEEKRYTYS-QLG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSVHLGERSTDRECCGNNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MLPPKYLSASKPKRSWAPDLYELDSDLTKEPDAIIGGGAADSEFFHQRF---RNFLYVEF
V--GPRKTLIKLRNLCLDWLQPETHTKEEIVELLVLEQYLTILPERIKPWVRA-------
----KKPQSCEKLV---TLLESYKE----MYEPEDSS-GDGHSEDSMSREGAASPPPRSA
CF-------------------------DR----------DWDRRGRSRDLEFRDRWP-YT
RNPRSRLPQRDLSLPVMEK-TFAMERGHRRRDCMMD-YESRSQDAVSYQDV-VDLTEDRK
PQNPIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSVYPST------SRGLK
TMPETKKSAHRRGICEDESSHGVIMEKFIKDVSRNPRSGRARECNDRS------------
------------PRFP--RRPDHDWRDISFNKRES--VIQERGYEGSAFGG-GSKCNPNL
VSRKRVLERKRRYQFDIDGQGSIHDQKVCPRKRPFECSEM----RKATSTSSL------S
SPSFTVSQPL-DFGAMPYVCDECGKAFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKRQA-RGKCFECKECGETFNKSAALAEHRKIHV-RKYLTEYN---EDEYEEPF
MPSPT-----------------------------FSELQKIYGKDKFYQCKVCKETFLHS
SALIDHQKTHGR----DDKDTVR--------------------------------GEAFK
PSPPLSELQKMYAKEKMYECKVCRETFHHSSALKEHQKIHTRANLFESKGKVCEETFIPS
QSLKRRQKSYSKEKLYDFKDGGVTFRQSSEL-TEHQKIHSRKNLYESRGYEKSVIRSVPC
TDSQKSHTI-TRPPENG---SEKAFTISSNPDDNQKLPT-QNVCERKPYERSVIHSLAFA
KAQRS-HSTGGTNKPKVI---AESTI-QSSSVVEH-QKVHTRENASERKKYQRSVIHSLA
AFRAPKSRSGSE-FECS-ERGESSIYISDLRE-QQKAPAR-ENPYEGCENN----NCKDS
VIRSVARAEPQKGLNAEGDSEYKKDGQS-VSTVNVREHQKARAKKKNIER---RNCETSV
IHSL-RFGEPQTFLPREKFYECLECGESFVHSSDLTEHQKIHDRKKTSGSRNYERSVIR-
---SLASTDPQTSYAEQQY-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VQQP
AQKECHECGQCFATIEDLSAHQKIYAQEEFH-GGKQLGDSVIQGVGPDRPE---------
-------------QGDPEDTIYGCKDCGLGFADRADLKDHQKV HG--REYLIDTREYTHS
VIHTHSVSEYQRDYTGEQL YECPACGECFVHSSFLFEHQKV HEQDQFYG--HRRYDEPFV
QPLVIN--PQRPRAPQKNP--STGLF LQCHVCGQDFIHGSVLNDHMTV HTGGNSPE--QG
QG---SGNAVSPGLALTELQRSQ--AEEKH YECETCGESFLSQSDLKDHMRI HEK-DEPY
DYGAAFVHTSFLTEPPKRDSSF FECKDCGKSFIHNTVLTKHQKF HVEEEE----------
-----AAAQEVEASVLVPREVLRIQGSNVEAAEPEVEATEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERAEEPAGKAEEPE
GDTDEPDGAGIEDPEEEGDDQEIQVEEPY YDCRECGETFASNSAYGEHLKT HARVIIFEP
GSIYGESSHYTEHASTSTS----------ASDNDRA-DDKY FKCDVCGQLFGDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNNSDVTSDDDMTRNRRESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-HT
RNPRSRMPQRDLSLPVVAKTSFEMDRDDDRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDISLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNEREHER------------------------ERERGETFR
PSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPRSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-ENPCEGGSKN-R--NYEDS
VIQSVSRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKCKEFRQFFATSEDLNTNQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGEESQGK-------------
NT---------------------------------DG-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHSEETH-GQETIEDPVIQSSDM-------------
---------EDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---VEEAIIPGLALTEFQRSQ--TEER LFECAVCGESFVNPAELAD-HV TVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEEEEDEAA-A--
--AAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAGQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ADAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------EGERPT---LGR-------GGG-RRWSQSSEL
GVPEQLH----------------------DGEKPHKC-SECGKS---FRW----------
-SSDLIVHQRI HTEERP YECGECGKRFSHSSSLIRHQRI HTGERP YECSKCGKSFSQSSH
------------------------------------------------------------
----------------------------------LIMHQRIHTGERPYECSKCGKRFQTS
SCLLRHYRVHTEERPF----------------------------------CCPVCGKGFR
ENSKLIQHRCIHTRERPYECGECGKSFSWSS-----------------------------
-SLIKHQRTHTGERSYECSECGKRFQTSSRL-LQHYRIHTEER-----------------
------------PFCCPD--CGKGFI----------------------------------
---------------------------HNSAFVRH-RRIHTGERP---------------
------------------------------------------------------------
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---------------

MLPPKHLSATTPKKSWAPNLYELDSDLTKEPDVFLHQRFRNLI-------------YVEF
V--GPRKTLVKLRNLCLDWLQLETRTK-EIIELLVLEQYLTIIPEKLKPWVRA-------
----KKPENCEKLI---TLLENYKE----MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
HSFS-DR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGECSIYISDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFGRISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKFKEFRQFFATSKDLNTYQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKDEET--------------
------------------------------------------------------------
------------------------------------------------------------
----------H-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------GEETYGEETH-GQETIEDPVIQGSDM-------------
---------EDLQKDDPDNAIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSVSEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERLFECAICGEAFINPAELAD-HVTVHK-DEPY
EYGSSYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKEL HLEDDDDDDEAA-A--
---AAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSE--ALTVRELAA-------------------------------
-----------------------------------PAFAGGAEPRIRGLLGSLEGRGLRS
CRP-------QEGRGQ--QAAPPRGEMQAAPAAQ---VGR-------AAG-GDPGLSSDL
LLLESEL----------------------AEGEARR--RACGRS---FPF----------
-SPESG--------------------------WDQRGRAAGGEGLPACSGCGQDLLLH--
--P--EQRPQA-GERPLKCAQCGKAFCHSSDLARHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVRQY----------------------------------ECSECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIIHTGEKPYVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECG-HYG------KEFSST--------------------------P
SFQSL------QD-----------------------------------------------
DPPEGLPLKKTPVHLGETHVGQGEGADS--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
RSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQKV-VDLTEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFSESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKPPRSHSGNELVESN-EKGECSIYISDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFGRISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKQQAWNKFKEFRQFFATSKDLNTYQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKESQGE-------------
KI---------------------------------RG-----------------------
------------------------------------------------------------
-------EETY-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------SEETHG----EETH-GQETIEDPVIQGSDM-------------
---------EDLQKDDPDNAIYECEDCGLGFVDLTDLTDHQKVHS--RKCLVDSREYTHS
VIHTHSVSEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAIRCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERVFECAICGEAFINPAELAD-HVTVHK-NEPY
EYGSTYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEDDDDDDDEA-AA-
-AAAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEPYYDCHECTETFTSSTAFGEHLKTHASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKYFKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--ELTVLEPSA-------------------------------
-----------------------------------SESREFHEDRLAQLLGNPEKQSLES
PSS-------QDRGFT--QMTVTHWKIQTGDTAQ---TCS-------KSG-RNPILNSNL
LILQREL----------------------IDGEAHSC-GVGGKG---FPF----------
-NSDVVPHQISHTGEKPYKCDHCGKGFSQTSLLTEHQRVHTGDRLYVCNVCGKDFVHYAS
LRE--HQHVHT-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECQECGKAFIRSSKLIQHQRI HTGERP YVC--TECGKRFSQT
SNFTQHQRIHSGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKMHTEEKLYTYS-QLG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSVHLGERSTDRECCGNNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------GEPVS---ACS-------QVA-RGAPLSPDL
-ALPPDL----------------------IEGDAHPR-DVCGQS---FSF----------
-SSDLIRQQGGHAG----------------------------KRLCVGRLCG-------D
LAE--QQHTPA-GDKPFPCAQCGKAFGHSSDLARHQRG HS-RERP FECP-----ECGKGF
GQSSL-----------------------------LIRHQRI HTGERP FECTECGRAFLRS
SSLVRHYQI HTEVRQY----------------------------------ECRECGKAFR
HRSDLTEHQRI HSGERP FECRECGKAFIRSSKLVQHQRV HSGERP YVC--AECGKRFSQT
SNFTQHQRI HSGEKL YVCQECGKAFFLSSYL-IRHQKI HTGERV YECRECGKAFLQKAHL
TEHQKI HSG-DRP FECQA--CGKAFI----------------------------------
---------------------------QSSKLLLH-QVV HTGEKP YVCSRCGKGFLQRAS
FLQHQKAHSEEGLHEGS-SLG------K--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

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------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G-RRWSQSSEL
RVPEQLH----------------------DGEKPHKC-SECGKS---FRR----------
-RSELIRHQRL HTGERP YECGECGKSFSHSSSLIVHQRIHTGERPYECSECGKRFQTSSC
L-L--HYPVHT-EERPFCCPDCGKGFRQNSHLLRHQRI HT-GEKP YDCP-----RCGKRF
SQSSHLTQHQRR HQLGEKP HKCSECGKGFRWRSDLIVHQRIHTGERPYECSKCGKRFQTS
SCLLKHYRVHREERPF----------------------------------CCPDCGKGFR
LNSNLIQHRRI HTGERP YECGECGKSFNRSS-----------------------------
-SLITHQRIHTGERPYECSECGKRFQTSSCL-LKHYRVHTEER-----------------
------------PFCCPD--CGKGFR----------------------------------
---------------------------KNSHLTTH-RRI HTGERP YECGECGKRFSSNSH
LTRHQRRHR---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
--------------------------------MILLSFVSDS----------NVGTGEKK
VTEAWISEDENSHRTTSD--RLTVMELPS-------------------------------
-----------------------------------PESEEVHEPRLGELLGNPEGQSLGS
SPS-------QDRGCK--QVTVTHWKIQTGETAQ---VCT-------KSG-RNHILNSDL
LLLQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHRIS HAGEKP YTCDQCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIHYSG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNST--------------------------T
NVKNN------QR-----------------------------------------------
VHQEGLSLSKAPIHLGERSVDKGEHTGNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

MLPPKFLSTTNPQKSRALGLWALDGD--------AGDGTSGSELSRQRF---RNLLYVEF
V--GPRKTLSQLRNLCLDWLQPETRSHEEIVELLVLEQFLTIIPERVKPWVLA-------
----QKPENCDRLV---TLLENYEEEEDEMHQPED---DAAHSDDDLSRVGAESPPPRSV
HS--------------------------------------FDRRGRIRDMGSRDQWP-YA
QTYRNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X-----XXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXQLAEDDGHSHMTQGHSSRSRRSAYPST------SRGLK
IMPETRKPSYWRGICEDESSHGVIMEKFIKDVSRNTRAGRMRDHMDRP------------
------------QRFP--GVLGDDWMEGPFSRRES--VILERGREGSVLGG-GLSLNSHL
PPRTQVLERKRRYQVDVDGKGAAPDQRGGRAKKPFARSQA----REATCVSSL------I
STSPVEWPPS-GWEALPYTCDACGWSYSVISEFIEHQIKHTRESLHDY---GESFIHSVA
LSE--ARKKLA-KAQRSERSASGDALGS-------ARKPR-REDLTECQ---EQEDEDAI
LPSPT-----------------------------LNELQRMYGKEKFYQCSLCQETFLHS
SALAGHQKTHRSGDSDSDCDHECG-------------------------------GKAPE
PSPAPTEPRTACGKESAGERKARAETLPRSPAPKEHPEAHARS-LSENQGTVWEETFIPG
QALRRQQEAPATEKLRESKDGRDAFVQSSDL-SEHPTRHSQKNLREGRGYQKSVICSVPC
PGSQKSHTI-TRPPGLEPEQEERACTVSANPEEQQRPPAHERVCEGRRCERSVIHRLVFA
DPQKS-HSPVELRKPRSR---AECTIVQSTDAMEC-ERAGAAESAAYGGXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-XXX----XXXXXXX-XXXX-XX-XXXX-XXXXX----XX--X
XXXXXXXXX--XXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXX
XXXX-XXXXXXXXXXXXXXX----XX-XXXXX-XXX---------------XXXXXXXX-
---XXXXXXXXXXXXXXXX-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------XX--XX------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-X----------------------------------------------------------
--------XXXXXXXXXXXXXXXXXXXXXXXXXXX-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------XXXXXXEAFSAEQR
RRHQCREFGKCFITRETLNCHQKVYCRERST--GPRPSSSVIQGLGFSRRQG--------
-------------QSVAECTIYECKNCGTGFTDLDDLRDHEEV HS--RNRLAGPRACRH-
----PSFGDAQRSSDGDQL FECPQCGESFISNSFLCEHQKL HEREPFYA--CRQYSEGSL
RRFRMHT--QKRRRSAKPA--LGSRN LRCQVCGQDFIHISVLEEHMRI HTGEDQPE--QA
KS---GEDTVVQGLALTEFQRDQ--TEERP HECKTCGETFLSQSDLRDHMRV HEK-GEPF
DYGATFLHTSFFDLPP-GDGPF YECKECGKSFIHNTILVKHQQL HVEEAE----------
------AAQEVEANFVVPQEVLRIQGSNVEAAEP--------------DLEAAEPSGEAE
QPTGEAAEPSGEAEQPG---GEAEQPSGEAALAAEEPHGAGIEDPGERAEE------EPE
GEAEEPEGAGIEDPEE-DEDQEIQVEEPY YDCQECAETFPSNSAYREHLKT HARMILHEP
GRGYGESSRYTGQASTS------------AGANDWD-DEKY FRCDVCGQFFTDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TMSD--KLTVLEPSA-------------------------------
-----------------------------------SEPGEFHEDRLVQLLGNPERQGLES
PPS-------QEGGFK--QMTVTHWKIQTGETAQ---MCS-------KSG-RNPILNSNL
LILQREL----------------------IEGEGHSC-GIGGKS---FPF----------
-NSNVVPHQISHPGEKPYQCDHCGKGFSQNSLLSEHQRVHTGDRLYVCNVCGKDLIHYAN
LVE--HQHVHT-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECQECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKMHTEENLYKFS-QHG------KDLTPP--------------------------P
DL----------------------------------------------------------
VHQEDLSLSETSVHLGETSMDQECHADNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------KGRSRGSEGERPT---MGW-------GGC-WRWSQSSEL
GVPEQLH----------------------DGEKPQKC-SECGKS---FRW----------
-RSELIVHQRT HTGERP YECGECGKSFSHSSSLSKHQRI HTGEKP YECEECGKSFSRRSH
------------------------------------------------------------
----------------------------------LLRHQVIHTGERPYECSECGKRFQTS
SSLLLHYPVHTEERPF----------------------------------CCPDCGKGFR
QNSTLIKHRRI HTGERP YECGECGKSFTQSS-----------------------------
-SLIQHQRIHTGERPYECSKCGKRFQTSSCL-LKHYRVHREER-----------------
------------PFCCPD--CGKGFR----------------------------------
---------------------------HNSILIQH-RRIHTGERPYECPRCGKRFSQSSN
LTKHQRRH----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNNSDVTSDDDMTRNRRESSPPHSV
HSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-HT
RNPRSRMPQRDLSLPVVAKTSFEMDRDDDRDSR--A-YESRSQDAESYQNV-VDLAEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDRS------------
------------QRFP--RMSDDNWKDISLNKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-RGYLVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNEREHER------------------------ERERGETFR
PSPALNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKKRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPLESDE--DEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPRSHNGNELVESN-EKGESSIYISDLNDKRQKIPAR-ENPCEGGSKN-R--NYEDS
VIQSVSRAKPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQAWNKCKEFRQFFATSEDLNTNQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGEESQGE-------------
NT---------------------------------DG-----------------------
------------------------------------------------------------
-------E----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ETHSEETH-GQETIEDPVIQGSDM-------------
---------EDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSISEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRL HREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEER LFECAVCGESFINPAELAD-HV TVHK-NEPY
EYGSSYTHTSFLTEPLKGAIPF YECKDCGKSFIHSTVLTKHKEL HLEEEEE-DEAA-A--
--AAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPIGEAGQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGVGIEDPE-EGEDQEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGANQA-DEKY FKCDVCGQLFNDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MMSD--KLTVLEPSV-------------------------------
-----------------------------------SESREFHEDRLAQLLENPETQSLES
PSC-------QDGGFT--QMTVAHWKIQTGDTAP---VCS-------KSG-RNPILDSNL
LILQREL----------------------IEGETRSC-GVGGKN---FPF----------
-NSDVDPHQVSHSGEKSYKCDHCGKGFSQTSLLTEHQRVHTRDRLCVCNVCGKDFIHYAN
LME--HQLVHT-GEKPFKCAQCGKAFCHSSDLLRHQRVHT-RERPFECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECRDCGKAFR
HRSDLIEHQRI HTGERP FECHECGKAFIRSSKLIQHQRI HTGERP YVC--NECGKRFSQT
SNFTQHQRIHTGEKLYECNECGKAFFLSSYL-IRHQKIHTGERVYECKECGKAFLQKAHL
TEHQKIHTG-DRPFECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QIVHTGEKPYVCSYCGKGFIQRSN
FLQHQKMHTEEKLYKYS-EHG------KDLAPP--------------------------P
DL----------------------------------------------------------
VPQEDLSLSETSVHLGETATDQERCGENF-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHHEDDTNSDMNSDDDMSRSGRETPPPRPS
HAFGSE----------------------R----------DLERRGRSRDVEPRDRWP-YT
RNPRSRLPQRDLSLPVMSRPHFGLDRDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRTAYPST------SRGLK
PMPDAKKPSHRRGICEDESSHGVIMEKFIKDVARNPKSGRARELNER-------------
----------PPPRFP---RPNDNWKDSSSSRRES--VIQERGYEGSAFRG-GFRFNADL
ASRSRALERKRRYHFDSDERGSGHEHKSCVRKKPFECGTEMRQ---AMSMGNL------N
SPSFSESQSID-FGANPYVCDECGRQFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGKRFECKECGETFSRSAALAEHRQIHA-REYLAECR---DQEDEETI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNSD-DRDNERERERDRLRARAREQRER-ERER----ERERELGEPFL
TCPNFNEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRMCEETFVPR
QSLRRRQKTY-REKLFDFNNARDALMGNSDP-SEHQKNRSRRNFFEGRGFEK------PF
VESQKSHTI-TRPPENKD--DDKPFTISVNPNDKLKFPIMENGSQGKSYERSVIHSLGSA
EAQKS-HGGLGFSKPRPV---AESST-QSSSSIYY-PRAHSGGNTYEGKEYKDSIIHSLP
APRPLKRNRANDHIQCD-EGGESSIYIPDIINKRRKIPA-REDAYEGSSSS----NY---
HTPNVSRAE-PPSLSGE-SHDSKQDVTFSVPSSSVREHQKARAKKKYIEPR---NNETSV
IHSL-PFGELLAGHRRAKFFECQECGEAFARRSELIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FRAFGQRSTTSN-NLSVQKIYAQE-----
------------------------------------------------------------
-------------------------------------TFNAEEPHDK-------------
ET---------------------------------HG-----------------------
------QKIHD-------------------------------------------------
-------KEPYG-----------------KEPSGKE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
----------------------MRSEEPH-----------------DDK-----------
-----------------------------------------------P---------HGQ
EPH----DDKPHGQEPH-------------------------------------------
------------------------------------------------------------
----------------------DDKPHGQEPH--------------------------GD
EPHGQEPHSDEPHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPHDK--------------------------------
---------------------------------------EPID---------------QE
------MHSEE---PHSEESHGDEPHGEESH-GQEKVEDATIQASVS-------------
---------EEHQKDDAGDAIYECQDCGLGFTDLNDLTSHQDTHS--RKALVDSREYAHS
EVHVHSVSEFEKKCSGEKLYECPKCGESFIHSSLLFEHQRVHEQDQLYS--VKACDDGFI
ALLPV--RPRRNCTVERNP-AVSGSAIRCRQCGQGFIHSSALNEHMRQHRDNE--IMEQG
EL---TDEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEI------
---VAATAQEVEANVLVPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECAETFASSSAFGEHLKSHASVIIFEP
ANAPGECSGYIERASTS------------AGGAEQAD-DKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
CSE-------CGKSFSRSSDLIVHQRIHTGERPY---KCS-------EYG-KRFQTSSCL
LLHYPVH----------------------TEERRFCC-PVCGKG---FRK----------
-NSNLTTHRRI HTRERP YECSECGKSFSRSSSLIMHQRT HTGERP YECSECGKRFQTSSD
LLK--HYRV HR-EERP FCCPDCGKGFRENSKLIRHRRI HT-GERP YECS-----ECGKSF
SQSSS-----------------------------LIMHQRTHTGERPYECSKCGKRFQTS
SCLLRHYWVHMEERPF----------------------------------CCPDCGKGFI
HNSTLIQHRRIHTGERPYECGECGKRFSRNSHLTEHQRR HRER-S YEC--LECGKSFKRI
SSLVHHQRI HTGERP YECGECGKSFRFKSNL-IAHLRF HTRERP YECPSCGKSFSQSSHL
TQHQRR HRGLHRP YECLE--CGKSFK----------------------------------
---------------------------RISSLVHH-QRI HTGERP YECGECGKSFRFKSN
LIAHLRFHTRERPYECP-KCQ------KRFHTN--------------------------S
CLLHH------YR-----------------------------------------------
VHTEE------------RPFCCPDCGKGFKHNSSLTVHRRIHTGE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MGRDS----------NVGTGEKK
VTESWISEDENSHRTMSD--KVTAMELPS-------------------------------
-----------------------------------PESGEVCEPRLEELLGNPEVQSLGS
SPS-------QDRGCK--QVTVTHWKIQTRETAQ---VCT-------KSG-RHPVLNSDL
LILQREL----------------------IEGEANPC-DICGKT---FTF----------
-NSDLVRHRIL HAGEKP YTCDQCGKGFGQSSHLMEHQRI HTGERL YVCNVCGKDFIRYAG
LIE--HQRV HS-GEKP FKCAQCGKAFCHSSDLIRHQRV HT-RERP FECK-----ECGKGF
SQSSL-----------------------------LIRHQRI HTGERP YECNECGKSFIRS
SSLIRHYQI HTEVKQY----------------------------------ECKECGKAFR
HRSDLIEHQRI HTGERP FECNECGKAFIRSSKLIQHQRI HTGERP YVC--NQCGKRFSQT
SNFTQHQRI HTGEKL YECNECGKAFFLSSYL-IRHQKI HTGERV YECKECGKAFLQKAHL
TEHQKI HSG-DRP FECKD--CGKAFI----------------------------------
---------------------------QSSKLLLH-QII HTGEKP YVCSYCGKGFIQRSN
FLQHQKIHTEEKLYECS-QYG------RDFNSA--------------------------T
NFKNN------QS-----------------------------------------------
VHQEGLSLSKTPIHLSERSVDQGEHTDNL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------G-RRWNQSSEL
GIPEQLH----------------------DGEKPHKC-SECGKS---FRW----------
-RSKLILHQRT HTGEKP YECSECGKGFSRSSHLIKHQRIHTGERPYECSKCGKRFQTSSC
LLQ--HYRVHM-EERPFCCPDCGKGFRQNSNLTTHRRI HT-GERP YECG-----ECGKSF
SRSSS-----------------------------LIQHQRIHTGERPYECSECGKRFQTS
SCLLWHYPVHTEERPF----------------------------------YCPDCGKGFK
DNSTLIQHRRI HTGERP YECPRCGKRFSQSS-----------------------------
-HLTEHQRRHRGERPTLGRGGGWRWSQSSEL-GVPEQLHDGEK-----------------
------------PHKCSE--CGKSFS----------------------------------
---------------------------HSSSLIMH-QRTHTGERPYEC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYQPEDDNSSDMTSDDDMARDRGESSPPHSV
RSFSGDR--------------------------------DWDRRGRSRDMEPRDRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNV-VDLTEDRK
PHNTIQDNMENYRKLLSL--GVQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSDQS------------
------------QRFP--RMSDANWKDVSLHKRES--VIQQRVYEGNAFRG-GFRFNSTL
VSRKRVLERKRRYHFDTDGKGSIHDQKGCPRKKPFECGSEMRK---AVSMSNLS---SLS
SPSFSESQPI-DFGAMPYVCDECGRSFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQV-GGKRFECKDCGETFNKSAALAEHRKIHA-REYPVECK---NQECEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNER----E----------------------RDRERGETFR
PSPTLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDSRDAFMQSSEL-SEHQKIHSRKNLFEGRGYEKSVIHSGPF
TESQKSHTI-TRPPESDE--DEKAFTISSNPYENQKIPTKENVYERKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVT---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
TSKSPRSHSGNELVESN-EKGECSIYISDLNDKRQKIPAR-ENPCEGGSKD-H--NYGDS
VIQSVSHARPQKSVPGEGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGE-QTFRPRGMLYECQECGECFGRISDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKQQAWNKFKEFRQFFATSKDLNTYQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKESQGE-------------
KI---------------------------------RG-----------------------
------------------------------------------------------------
-------EETY-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------SEETHG----EETH-GQETIEDPVIQGSDM-------------
---------EDLQKDDPDNAIYECEDCGLGFVDLTDLTDHQKV HS--RKCLVDSREYTHS
VIHTHSVSEYQRDYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--MKGCDDGFI
ALLPM--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERVFECAICGEAFINPAELAD-HVTVHK-NEPY
EYGSTYTHTSFLTEPLKGAIPFYECKDCGKSFIHSTVLTKHKEL HLEDDDDDDDEA-AA-
-AAAAAAAQEVEANVHVPQVVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEE-------PE
GDADEPDGVGIEDPE-EAEDEEIQVEEP YYDCHECTETFTSSTAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGANQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---EQLH----------------------DGEKPHKC-SECGKG---FTW----------
-RSELILHQRT HSGERP YECGECGKGFSRSSSLIKHQRIHTGERPYECSKCGKRFQTSSC
LLR--HYPVHT-EERPFCCPDCGKGFKDNSTLIQHRRI HT-GERP YECG-----ECGKSF
SRSSS-----------------------------LIMHQRIHTGERPYECSECGKGFQTS
SCLLQHYRIHTEERPF----------------------------------RCPDCGKGFR
DNSTLIQHCRI HTGERP YDCGECGKGFRHRS-----------------------------
-GLIKHQRTHTGERPYECSECGKGFQTSSHL-LQHYWVHTEER-----------------
------------PFRCPD--CGKGFR----------------------------------
---------------------------QNSHLLRH-QRI HTGERP YECPRCGKRFSRNSH
LTKHQGRHRRAKLH----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

-MPPKHLSVTKPKKSGAPNLYELDSDLTKVSHHRRRPNPDQTPKP----------LDLHQ
G--GDHRALV-----------------------------PDHHPCKAQALGAA-------
----KKPENCEKLI---TLLENYKE----MYQPEDDNSDVT-SDDEMTRNRGESPPPRSV
YSFS-DR--------------------------------DWDRRGRSRDMEPRGRWS-YT
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESRSQDAESYQNM-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAYPS--T----SRGLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSRRARESSNQS------------
------------QRFP--RMSDDKWKDLSLNKRES--VIQERVYEGNSFRG-GFRFNSTL
VSRKRILERKRRYHFDTDGKGSTHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISGFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQI-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---DQEYEEAF
MPSPT-----------------------------FSELQKIYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNDHER--E----------------------RERERGEAFM
PSSTLNEFQKMCGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNIFEGRGYEKSVIHNMPF
TESQKSHTI-TRPPESDE--DEKPFTISSNPYENQKIPTKENVYEGKSYERSVIHSLDSV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPKSHNGNELVESN-ENGESSIYISDLNGKRPKIPAR-ENPCEGGSKN-H--NYEDS
VIQSVSHAKPQKSVPGKGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGKQQTLRPRGMLYECQECGECFAHRSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKRKEFSQSFATRKDLNTHQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKKSQG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------EETHGEETH-GQEIIEDPVIQGSDM-------------
---------EEPQKDDPDDTIYECEDCGLGFVDLTDLTDHQKV HR--RKCLVDSREYTHS
VSHTHSISEYQRNYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--LKGCDDGFI
ALLPV--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERLFECAVCGESFVNAAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAMPFYECKDCGKSFIHSTVLTKHKEL HLEEEEDDDDDDDDDD
DEAVGAAAQEVEANVHVPQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NGEAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPE-EGEDQEIQVEEP YYDCHECTETFTSSAAFGEHLKT HASMIIFEP
ANAFGECSGYIEHAST------------STGGADQA-DEKY FKCDICGQLFSDRLSLARH
QNTHTG---------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------MYHHEDDTNSDMNSDDDMSRSGRETPPPRPS
HAFGSE----------------------R----------DLERRGRSRDVEPRDRWP-YT
RNPRSRLPQRDLSLPVMSRPHFGLDRDDDRRSM--D-YESRSQDAESYQNV-VELKEDKK
PQNPIQDNLENYRKLLSL--GVQLAEDDRHSHMTQGHSSRSKRTAYPST------SRGLK
PMPEAKKPSHRRGICEDESSHGVIMEKFIKDVARNPKSGRARELNER-------------
----------PPPRFP---RPNDNWKDSSSSRRES--VIQERGYEGSAFRG-GFRFNADL
ASRSRALERKRRYHFDSDERGSGHEHKSCVRKKPFECGAEMRQ---AMSMGNL------N
SPSFSESQSID-FGANPYVCDECGRQFSVISEFVEHQIMHTRENLYEY---GESFIHSVA
VNE--VQKGQG-GGKRFECKECGETFSRSAALAEHRQIHA-REYLAECR---DQEDEETI
MPSPT-----------------------------FSELQKMYGKDKFYECKVCKETFLHS
SALIEHQKIHGRGNSD-DRDNERERERDRLRARAREQRER-ERER----ERERELGEPFL
TCPNFNEFRKMYRKDKIYECKVCGESFLHLSSLREHQKIHTRGNPFENKSRMCEETFVPS
QSLRRRQKTY-REKLFDFNNARDALMGNSDS-SEHQKNRSRRNFFEGRGFEK------PF
VESQKSHTI-TRPPENKD--DDKPFTISVNPNDKLKFPIMENGSQGKSYERSVIHSLGSA
EAQKS-HGGLGFSKPRPV---AESST-QSSSSIYY-PRAHSGGNTYEGKEYKDSIIHSLP
APRPLKRHRANDHIQCD-EGGESSIYIPDIINKGRKIPA-REDAYEGSSSS----NY---
HTPNVSRAE-PPSLSGE-SHDSKQDVTFSVPSSSVREHQKARAKKKYIEPR---NNETSV
IHSL-PFGELLAGHRRAKFFECQECGEAFARRSELIEHQKIHDRERPSGSRHYERSVIR-
---SLAPSDPQTSYAQERF----IQEQVRK-FRAFGQRSTTSN-NLSVQKIYAQE-----
------------------------------------------------------------
-------------------------------------TFNAEEPHDK-------------
ET---------------------------------HG-----------------------
------QKIHD-------------------------------------------------
-------KEPYG-----------------KEPSGKE------------------------
-----PHGDEPQDKEPLDQE----------------------------------------
----------------------MRSEEPH-----------------DDK-----------
-----------------------------------------------P---------HGQ
EPH----DDKPHGQEPH-------------------------------------------
------------------------------------------------------------
----------------------DDKPHGQEPH--------------------------GD
E----------PHG----------------------------------------------
------------------------------------------------------------
-----------------QEPHGDEPHDK--------------------------------
---------------------------------------EPID---------------QE
------MRSEE---PHSEESHGDEPHGEESH-GQEKVEDATIQASVS-------------
---------EEHQKDDAGDAIYECQDCGLGFTDLNDLTSHQDT HS--RKALVDSREYAHS
EVHAHSVSEFEKKCSGEKL YECPKCGESFIHSSLLFEHQRV HEQDQLYS--VKACDDAFI
ALLPV--RPRRNCTVERNP-AVSGSAI RCRQCGQGFIHSSALNEHMRQHRDNE--IMEQS
EL---SDEIFIQGLALTEYQGSE--TEEKLFECTICGECFFTAKQLGDHHTKVHK-DEPY
EYGPSYTHASFLTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEI------
---VAATAQEVEANVLIPQEVLRIQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPDGEAEQPN---GEAEQPNGD----ADEPDGAGIEDPEERADEPEEDVEEPE
GDADEPDGADIEDPEEEGEDQEIEVEEPYYNCHECAETFASSSAFGEHLKSHASVIIFEP
ANAPGECSGYIERASTS------------AGGAEQAD-DKYFKCDVCGQLFNDRLSLARH
QNSHTG---------

-LPPKH--------LSAPNLHELDSDLTKEPGVIIGEDPTDSEFFHQRF---WNLIFVEF
L--GLQKTLIKLQNLCLDWLQPEICTKE-IIKFLVLEQYLTIIPEKLKPWVPA-------
----KKPENCEKLI---TLLENYKE----MYQPEDDNSDVT-SDDEMTRNRGESPPPRSV
YSFS-DR--------------------------------DWDRRGRSRDMEPRGRWS-YP
RNPRSRMPQRDLSLPVMAKTSFEMERDDDRDSR--A-YESQSQDAESYQNM-VDLTEDRK
PHNTIQDNMENYRKLLSL---VQLAEDDGHSHMTQGHSSRSKRSAHLTEEP----HNSLK
TMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARESSSRS------------
------------QRFP--RMADDNWKDLSLNKRES--VIQERVYEGNSFRG-GFRFNSTL
VSRKRILERKRRYHFDTDGKGSTHDQKACPRKKPFECGSEMRK---AMSMSSLS---SLS
SPSFTESQPI-DFGAMPYVCDECGRSFSVISGFVEHQIMHTRENLYEY---GESFIHSVA
VSE--VQKSQI-GGKRFECKDCGETFNKSAALAEHRKIHA-REYLVECK---DQEYEEAF
MPSPT-----------------------------FSELQKMYGKDKFYECRVCKETFLHS
SALIEHQKIH----FGDDKDNDRER--E----------------------RERERGEAFM
PSSSLNEFQKMYGKEKMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPG
QSLKRRQKTYNKEKLYDFTDGRDAFMQSSEL-SEHQKIHSRKNIFEGRGYEKSVIHSMPF
TESQKSHTI-TRPPESDE--DEKPFTISSNPYENQKIPTKENVYEGKSYERSVIHSLASV
EAQKS-HSVAGPSKPKVM---AESTI-QSFDAINH-QRVRAGGNTSEGREYSRSVIHSLV
ASKPPKSHNGNELVESN-ENGESSIYISDLNGKRLKIPAR-ENPCEGSSKN-H--NYEDS
VIQSVSHAKPQKSVPGKGSGEFKKDGEFSVPSSNVREYQKARAKKKYIEHR---SNETSV
IHSL-PFGKQQTLRPRGMLYECQECGECFAHRSDLTEHQKIHDREKPSGSRNYEWSVIR-
---SLAPTDPQTSYAQEQY----AKEQARNKCKEFSQSFATSKDLNTHQKIYDQE-----
------------------------------------------------------------
-------------------------------------KSHGKKSQG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------EETHGEETH-SQEIIEDPVIQGSDM-------------
---------EEPQKDDPDDTIYECEDCGLGFVDLTDLTDHQKV HR--RKCLVDSREYTHS
VSHTHSISEYQRNYTGEQL YECPKCGESFIHSSFLFEHQRI HEQDQLYS--LKGCDDGFI
ALLPV--KPRRNRAAERNP-ALAGSAI RCLLCGQGFIHSSALNEHMRLHREDD--LLEQS
QM---AEEAIIPGLALTEFQRSQ--TEERLFECAVCGESFVNAAELAD-HVTVHK-NEPY
EYGSSYTHTSFLTEPLKGAMPFYECKDCGKSFIHSTVLTKHKEL HLEDDD-------DDD
DEAAGAAAQEVEANVHVLQEVLRIQGSNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAE
GPDGEAAEPNGEAEQ--P-NIGAEQPNGD----ADEPDGAGIEDPEERAEEPEGKAEEPE
GDADEPDGAGIEDPE-ESEDQEIQVEEP YYDCHECTETFTSSAAFGEHLKT HASMIIFEP
ANAFGECSGYIERAST------------STGGADQA-DEKY FKCDVCGQLFSDRLSLARH
QNTHTG---------

Query Results

"ENSGT00910000144259_0"

ENSGT00910000144259_0