ENSGT00910000144214_0 : Linker Region Query Results

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-----------------------------LVH-SDLDLLKKGLEEVWEVVKKLLLEGLLY
DPDSAA-GFRRKLFERVKCI-----SCDRPVEMMTG------------------------
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-----------------------------------------------------PQLITIR
K----------------------------AR-----------LL--------------SK
L--------------------RPASANSYEY---------LQRQM--MREQQ--RL----
-------------Q---------------LQEDGLHTLGAQQDWGDS-------LQND--
TTLKFKPGELSTLYPYGDPQVLNY-----DTAEVDILGVDGILYKGRMNTQFGAQPLTTA
EKELAA------------------VKVPC-------PP----------------------
-------------------------------------------------ARNL----Y--
-----------------A------------------------------------------
------------------------------------------------------------
-----------P----------VRSSDLFGTICPP-LGPRP-GA--CS----------AT
---PG--S-PS-----------------V--TLAQ----PPSL--PPLPLLP-----PLF
PPLRN--P---------------------------QQAPEPTR-----------------
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-------------------------------HLRS-------------------------
-----------LRPE---------------------------------------------
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---

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------------MENSVSEAS--LYLQEQLDKLRTIMENMMASSSTLLSMSMT-TPHKTL
TTVAPGQIHPEATCPACSLDVSHQVSMLVQRYEHLQDMVNNLAASRPSRK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTGNLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEKEKANRENLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLAEMDN-KLDRLELDPLKQTLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPLTGQIMPLTPVGPGLP
GHR--SMRPYTVFELEQVRQQSR-NLKLGS-SFPRGDLTQMERSVGRL--------RTMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSSPCYKRVSD-TADYTYSTVP
RRCGGSHTLTYPYRR-SRLQHLSQGLCPTDEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILTKDT----------------------------------AGMSKPKSKQSRSHR
---QQSLIDSS--------QLPSRPQSAQMLAANNPGISTRHRKDRPVSSE-AHLSQ-TL
VHPPSPMVMV--ELRGS-----PQGLQMH------MDVPPG--EGMEEPTRGPRSTTAHR
SDL

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------------MENSVSEAS--LYLQDQLDKLRTIIESMLASSSTLLSISMT--PHKPL
TYFTPGRIDPNATCPACSLDLGHQVSTLVQRYEQLQDIVSNLAASRPSKK--A---KLQS
QDEELLGQVQSAILQVLGDCEKLNITTSNLIEDHQQKQKDIDM-----------------
-----------------LYQSLEKLEKEKANREHLEMEIHVKADKSALAAKVSRVQFDAT
TEQLTHMMQELVAKMTGQEQDWQKMLDKLLVQMDS-KLDRLELDPVKQLLEDRWRSLRKQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETAVTGQMIPLIPMSPGLP
AHR--SIRPYTIFELEQVRQQSR-NLKLGS-TFCRGDLSPMERSAGRL--------RTMH
SKMLMD----IEKVQI-HFGGSVKASSQMIHELLQAQGLTSPCYKRVPDAMVGYTYSTVP
RRCGGSHTLTYPYRR-SRQQHLSQGPYAPEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILNKDT----------------------------------SGVSKHKTKQPRPHL
L-RHQALGNIG--------QLPSRPQSTHLLAGNNSV-----------SSR-QHLSQSDM
AHPPSPTEME--HLQDN-----GSGPEMH------MDIPPE--EELEEPTRGPRSTTAP-
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKTRADLLTS---------PSTSLR-----KEV-
-----TCKN-MLTRMDIFAEDFKIQNRKMISLQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFASEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEDSSSAQAVSLSSAQEPVQPP
ALT--PESAPGRAT---AFAP--GPAPGTEPVPGPELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPMVGPAP-------------------APGA-Q-
-----------------PPPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPILR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRGGKDGAPKDRGGKDGAPKDRAHKDEVPKDRGGKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASISPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLANMGGS--ASLGTTVDMLQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------QAM-KDCYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDKWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQH--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSV-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
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-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
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-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
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---

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------------MEHSVSEAS--IYLQDQLDKLRTIIENMLASSSTLLSMSLNMAPHKPL
TTLAPSQIDPAATCPACSLDLSHQVSMLVQRYEQLQNMVSNLAASRPSKK--A---KLQS
QDEELLGHIQSAILQVQGDCEKLSITTSNLIEDRQQKQKDIDV-----------------
-----------------LYQGLEKLEREKANRGHLEMEIGVKADKSALAAKVSRVQFDAT
TEQLNRMMQELVAKMTGQEQDWQKMLDKLLVEMDS-KLDRLELDPVKQSLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETAVTGQVIPMTPVGPCLP
GHR--SVRPYTVFELEQVRQQSR-NLKLGSSGFLRGDLGQVERSVGRL--------RTMH
SKMLLD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSSPCYRRLPD-MADYSYSSAP
RPCGGSHTLTYPYRR-IRLQHLSQGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPDLLNKDSECPDGPEALGLLAW--------VPQGL------SDAGMKHKAKQSRAHG
P-RQQSLSNSG--------QLPSRPQSAQTLAAKDSA-PSHHQKDRPVSTE-GRLSQLNP
AHLPGET------------ANLPAGLDVH------RDAPPG--EGLEEPTRGPRSTSAH-
---

---------------MSFSVTFSELANIAI--PQCGVVNFKALHLLIQGILDHIQISGLK
KVLSGDEDFLQT-SQVVI--------------MPREGEA----Q-----------TIINP
MKRLSNIFDTVVERINKIENQI----SSMQTMPT--------TTSLLEA---------SQ
GTSRPAEEMWNTIKLLKRIEAIEEVTAKFMKTLQDLLNDLYILKRTVETLQ-----KDVD
LMKFIFGKV-NPEKMELICEDLKVQNRKLGALQREVVTLQDKVGAIPEPKDMVLWSG---
LHEAMFSPV------------------------IN------WSSSLQR-------SKEE-
----------LGQFED--EDHIAHPTKTFMPVGTTGPLERQE-FAQADEFRGPLGLQQTR
--VSMT-----------ETVP------G------------------------P-------
--------SFGPRGR---------------------------------------------
-----------------PGF--IPSSWPRP--------ELAVPGAW-PLPPRGLPGA-LP
GALPGAWP---GAPGAWP---GAPGAWPGAWP--GAWPGAL-------------------
----------------------------------PGA-LPGALPGPGLRPFGPQG----Q
MYRAPF----PAMEAGPQHQVPKTG--------TP---LSD-----LEERDEYEY-----
G---YM---EQVPRDGAPQDGVPKEEAPQDGVTKEEAPQVGVPKERAPQDGVPKEGAPQD
RAPKDRVHH-----HRAHRRRVPKDG-----APQDSASKDTVHKDKEQKDKTP-EAQSKH
SLSALKKLKSVASVAAATAAAYAA-AANTAAQRATAALKAIKD-PESKLASSASTMAAGG
PLEAFADFLGSGTSPG-----ATDIIPY-----------------SDDEL----------
QEL----VETL-TPAT-RPTTPRSALSQAMVTASQAVS---------------PEEK---
--------------------------------------------KAAVQYS-----MSHL
A--------------------------------------QMPVRHDSLKEELVHLST---
-------------------------------------KLN--------------------
---QRLDYLAKMGSS--GKLGNAVNVLEEK-I-----------CNLQKARLEEEELERIW
GHQI------------------------------ETM-KSHYIVLDRT----------VE
KLQIRMDDFK-TLKAEIQRLDLIKADKTMMEQE---LREKANRDALASKASRTDLEV---
------------------------------------------------VATELNEIVQSM
LLKITTQEDDWKKSLKQ----LRKDLNTKIVH-SDLNSLKKDIEEVWKTLRKLLIEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRKIEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIH
N----------------------------TH---------------------------WK
V--------------------RPASANSYEY---------LQRQL--MREQQ--QQ----
-------------LHYQNF---------GVHEEGL---GSQKDWGDG-------PRND--
TTFKHKSHDLSTIYPYGDPELMDY-----DTAEVDILGVDGVLYKGRMNSQFGTRT---G
EKDLAA------------------MKVSS-------PS----------------------
-------------------------------------------------VQNM----N--
-----------------D------------------------------------------
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-----------R----------VRSGSILTSSYPP-LGTRTSSA--TT------------
--------YLH-----------------S--PSGQ----PPSL--SPVQQLP-----PLM
PHSRD--P---------------------------QEAPASTR-----------------
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-------------------------------HLKS-------------------------
-----------LRL----------------------------------------------
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---

---------------MSFSITFTELVNVAI--PQCGVVNFKALHLLLQGILEHIQIAELK
KVLSGEEDFLQS-SPAVF--------------MPREGDA----Q-----------PIINP
MKRLSNIFDQVVDRIEKIECKL----AEMQDIPT--------TSQLVED---------SH
GDKRPAEEMWNNIKIQKRIEGNEKATEKFTRTLQDLLSDLHVLKSSVATIQ-----KDVD
TIKFIFEKV-NPQKLELLGDDLKTQSRKLGALQREVVTLQNKVRAVPQPEEMVLWSG---
LHEAMFSPEQ---------------------QKLEMEQSGVWQSMVSL-------PESPL
EQP-----EDAGYIHI--PIHSATPVPTMVQFGTTGALREEE-LTRAEELADSQRLERAQ
ASVSLTQ----SLR---QAAP------A------------------------A-------
--------APAP------------------------------------------------
-----------------------------------------------TAAP----AP-TP
VPVPVFVP---GPDFMPVYGPRPGMATPSAWALPRGWARGNV------------------
----------------------------------QPM-WNMGPYQPGQGPLQPMG----P
TPRVPF----PAMGSGILWSQSLPQE-----P-QW---YPETEEKGTEYEEQYLE-----
G---YQ---EEMPMDEAPQEEMAVYGALEEEVPTEGVPQDGIPKGRAR-ERIPKGKVPKY
KIPKERVSY-----HKAPKDVTPEDSDTKDEVPEVKVLKKVAYKDRPQKDKAL-EPRHKG
PSSAIRKLKSAIATAAAAAAAYAA-HANSAAQLAKDAVKAIQDVPASQLATKAALIASSG
PLGAFADFLGAGFGHG-----ATSSIPF-----------------GEGEL----------
EGF----PEEF-AAPF-NPFTSKPVLSQAMINAMQATS---------------PEEK---
--------------------------------------------KKAVQYS-----MSHI
A--------------------------------------QMPSRHNSLKEEFTNLST---
-------------------------------------TLN--------------------
---QRLNYLANMGSS--GVLGSTVNVLEEK-I-----------INLQKARLQEEELERVW
GHQI------------------------------DTM-KSHYTVLDRA----------VE
RLQIRMDDLK-VLKAEIERLDLVKADKRVMDLE---LNEKANRDALASKANRVDLET---
------------------------------------------------AAMELNEMIHSV
LLKITNYESDWKKALKH----IRKDMNTKLVQ-SDLNSLKKDIEEVWKVVRKLLLEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TP-----------GL--------------SR
I--------------------RPASANSYEY---------LQRQL--MREQQ--QQ----
-------------LHFQNF---------GVHEEGQ---GFQKDWGDG-------PRNE--
NILKHKSHDLSTLYPYGDPELMDY-----DTAEVDILGVDGVLYKGRMSSQFGTRA---G
EKDIAA------------------VKVSY-------YT----------------------
-------------------------------------------------IPNL----T--
-----------------D------------------------------------------
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-----------R----------VRPGSLLAPGYPP-LVSRTSIT--SA----------TT
---LH--SATN-----------------I--TTAR----PPSL--PPVPQLP-----PLI
PVSRD--T---------------------------QEAPGSAK-----------------
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-------------------------------RLKS-------------------------
-----------PRL----------------------------------------------
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---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFSALHTLIVAMLKNLDLQNTR
IDFQPSSPEPSRSLQSVRS-----SFSISHLPAPKEVPKGAPREKRRGVGQAPSSALESQ
VKDLGGQVEDLSKQLKRVDGQVQGIATHVQHFSQASG-LDLAALEWPEEQEVGARALDRL
RTGS-----I-MKD---------------------------------AAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLT
GFS-----KRGGF--TSL--TSPEG-TLSGAST------KQPSIEQALDSA--SGLGPDR
TA-SGSGGTAHPSDGVSSREQSKVP-----SGTGKQQQPRA---RD-EAGIPR-------
--------LHQSSTSQFKSDSDRHRSREKLTS----------------------------
------TQPRRDAQ--------DARPGPVQQDLPSARD-----------QPSRVPAS-QS
QVHL--RPDRRG-----LEP---TGMNQPGLVPASTYPHGVVPLSMGQ------------
----------------------------------------LGVPPPEMHDRELIPFVMDE
-QCMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEP----------L
GM--DR---RGFVISGMGQQGLVPPGMDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHALV--QRGAYQPGL------VQPGADQRGLVRPRMD---
------------------QSGLAQ-------------------PGRDQHSLVQPGT----
------GQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQHALVQPGAYQPGLVQPGAD-QI
DVVQSGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQ---------------------
--------------------------------------RGLAQPRE-DQ-----------
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--------------------RMVQ-----PQADPHGLVQPGAYPLGL----------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------RGLVQPGM--
-----------------D-QYGLR------------------------------------
-----------------------QPGAY--------------------------------
-------------------QPGLIAPGTKLRGSSTFQADSTGFI--SVRP---YQHGMVP
---PGREQYGQ-----------------VSPLLASQGLASPGI--DRRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPGPGE--HDQVYPDAAQHGHA-
------FSLFDSRDSMYP-GYRGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DRRGI
PAQKAP-GQDVTLFRSPDSV---DRVSSEGSEVSSEVLSERRDSLCRMSSSFPTAVETFR
LMGELSNLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQIVKRTIPPELQEQ-LKTVKTLA
KEVWQEKAKVERLQRILEGEGNQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAISRPSKK--A---KLQR
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTEHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMK----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILRKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLSSNG--------QLPSRPQSAQISAGNTSER----------------------
------------------------------------------------------------
---

---------MPP-ATATATVSLRELADLAIGTPEVGAVNFTALHTLIVAMLRSLNLQEVR
INFQSPSPESSRSSELPR-----TVLSAPQLAVPKEKPRSS-SARPPA-LESQ-------
-------VKDLSKQLKTVTSQVQGIMSHVQHLTYPVGRLPVDSQDWLEEEMAVLLP-DRA
RGGS-----M-KIGKDGEQDGERASVTKAAVLLHDVAEDVKALKEAKEKAQEH-SEKAFQ
RMDE-------LEKIIRERD-----------KFLDLVGRKLSLMPVGEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETTG
LLK-----RKKHT--SLT--S------DDGAST------KHSSADPTVDSA--NGHGSDR
TL-SGIGATGYPSEGVGRERK-KSTPTT--ASPGREQHPRA-------RDEAGV------
-AKSHHP-----SVSQFRLESDRHRT--------------------------------RE
LQPHTSAYLRKDERE--------AHPGLVQQDLPSATAIRDRHPRVYPDQHGGVHVS-DG
QIYP--RPDQHG-----IAP---LGMDQLASLDHSTYPHSVVPLSMGQ------------
----------------------------------------LGMMPPGMDEQGSVLPGMDP
-RGMMPPLVPGRDQQGLQLPSTDQPGMVPFSTYQHGMIFPGTDQQ----PDVAQRGLVPL
HM--DQ---HGFLISGMDQQGLALPGMDQHGL----------VPHLIAQHGLGPTGT---
----DQNA-----------------------------------------LVQPGLVQPGM
DQRGLVQP--------VVDERGLV--QPGAYLPDW------VQPGAYATGWVQPGAYPLE
LVYPDVYPSGLVQLGA-DQPGLMQPGLG---------QQDSVQPGMDQYDLGQPGMDQRG
LVQLGMDQRGLVQPGTVQPGLVQPGAAQPGLVQPGAGQPGLVQPGAGQPGLVQPGAA-QP
GLVQPGAAQPGLVQPGAGQP----------------------------------------
------------------------------------------------------------
GLVQPGMDLGGLVQPGTGQRGLAQPGPAQPGLVQPGAAQPGLV---------------QP
GAGQPGLVQPGVAQPGLVQPGAGQRGLVR-------------------PVAGQRGLVRPG
AAQVGLVQPGAAQPGLVQPGAAQRGLVQPGAAQPGLVQPG---------------AAQPG
LVQPGAGQPG-LVQP--------GAAQ----PGLVQPGAAQPGLVQPGAGQPGLVQPGEG
-QPSLVQPGMDLGGLVQPGMDQHVLVQPGAAQPGLV----------PPGAGQPGVVQPGM
DQRGLAQP----------------------------------------------------
-----------------------------------GSAQ----------PGLVQPAMSQY
GLAQPGARQPGLVQSGVSQPG--------------------LVQPQMGQPALVQPGAG--
---QPGAGQPGLVQPGMDQ-----------------------------------------
------------------------------------------------------------
------------------------------------------RGLVYPGA----------
DQGGLAQPGAGQL-------------------------DLVQPGAGQ--PGLVQRGVGQR
GLVEPGTGPRGVFQPGAYPPGLLQ-----PGAYLPGSVEPGAYPQGLVPP----------
GAYPRGLVQSGALP----------------------------------------------
--------------------------------------------------RGFMQPLT--
-----------------D-QRGLR------------------------------------
-----------------------QPGRD--------------------------------
-------------------QQGSIPSSTELRGFPTFHPESLRFI--SPHP---YQHGVMP
---PSRGQHGQ-----------------VSPLLSGQGLAPPGT--DQEGLS-------ET
YQPGVIHPGT--DQGG-------------------------------QIKPGADQHDQS-
------HSIPESRDLTYP-GPRGPGFPGADQ-LQV-------------------------
-------------------------------------SVDPQQTYTS--------DRAGI
SVQTTP-SQEATFAKST---VFLNDL-YRASSERVDIQSERHDSLDKLSPSFPIAVETFR
LMGELIGLYVEFKENMKELDEEKAGQTDLEKLQYLLSLMVKKTIPPDLQEQL-KTLKALT
KEVRQERAKLDKIQRLLEGEREQEIGKEM--KD--GQLST-QLGIL-RVTVADIEKELAE
LRESQERG-KVSMEHSVSEAS--LYLQDQLDKLRTIIESMLASSSTLLSMSMT--PRQIP
TASAPSQIDPETTCPACSLDLGHQVSMLVQRYEQLQDMVTNLAATRPSKK--A---KLQS
QDEELLGHIQSAILQVQGDCEKLNITTGSLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEKEKATREHLEMEIDVKADKSALEAKVSRVQFDAT
TEQLNHMMQELMSKMSGQERDWQKMLDKLLVEMDS-KLDRLELDPVKQLLEDRWKALRQQ
LK-ERPPLYQADEAAAMRKQLL-------AHFHCLSCDRPLETPVTGQIIPVIPMGPGLP
GHR--SIRPYTVFELEQVRQQSR-NLKLGCAPFPRGDLAHTERSVGRL--------RTMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSSPCHRRVPD-MADYTYSSAP
RRCGGSHTLTYPYRR-NRLQHLSQGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRID
TRLPGIPSKDTPVSA------------------------------SGMTKHKAKQPRPHT
H-WQQSLSVSS--------QLPSRPQSAQMLAGNNSA-PSHQRKDRPVSSE-GLLSQPNV
AHPPSPSEMG--N---R-----PADVDAH------LDVPPG--EGLEEPTRGPRSTTAH-
---

---------MPP-ATPATKVSLRELADLAIGTPEVGAVNFTALHTLIVAMLKNLNLQETV
IDFHTLSPKGGRSVEALQAPSRSTLSSAPQLHHSKDQHKTASRSSSHA-LGSQVEELGSQ
VKELGSQVEGLTKQLKTVDSQMQVIAAQVQQITSTSTELGFEAPTVLEVK-NMSMP-DTE
EA---------QI----RSTEVQEDVRKPMNLLHDVVEDVKILKEAYQKAQELKPQEVFQ
RIEK-------LEKLIKERD-----------DFLEYMGQKLTLVPSGEEVTMVTWEE---
LEEAIA---------------------------------NGWKASQV-------GSETAL
GLS-----KRKVQ--SSL--TSSDL-IQSGVST------KYTSTDHIPDSA--GGPRQPL
---PGSSATGHLYEAVTI--K-QRGKGS--FAPGREQHTRA---HA-EANAS--------
-------RFYQPSIPQFRTESDHHRSREQFTS----------------------------
------GYPRRD-----------IHTGPAQQDLPLAR---------------DQPIG-QG
QVYV--RPDHHE-----LGL---PGIDQLGLPYASTTLPGVVPISVSQ------------
----------------------------------------LGMLPPQMDCQGLEPLGMDQ
-RGVVPPLVPGRDQQRSGLPGTDQLGVVPLSPYQYGMIIPGTDQCSMKQPGMPESGMRPL
GI--DQ---HGFVTLGVNQGGLVPPGGVQQGLEPSGIDQHGLSPVPIDRHGLVSPGLIQV
NA--DQQGF------------------------------------VQPSLETSGFIQPGT
EQHDLIWP--------DRNQSTLG--QPGTYRPGL------AQPGAEQHGLVQPGEH---
-----------------------------------------------PPDLVQPGKDQDS
LIQPGLDQRRLIQPGTVQHGLTQPGVAQLDVAQHGADQHGLVHPEMGRHDLMQPGTF-PS
GWVQPGAYPP--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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----------------------------------AWAQAG---------------ADSHR
PVQPGIGQHG-FVQP--------RMDQ----SDVVQLGADQQ------------------
-----------------------GSVQPGADQQGSVQPGADQQGSVQPGADQQGS-----
------------------------------------------------------------
-------------------------------------------------VLLVPPGMDQ-
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RGLVQPGM--
-----------------D-QHGWR------------------------------------
-----------------------QPSAD--------------------------------
-------------------HQSLIVPGTELCRFPPFQADLRSLRSPHPYP---YPRGMVP
---PGQEQHGR-----------------LSPFLASQASSSPRT--DKESI----------
-----------------------------RPDQQYLVSPGPDQ--QAQIYPGAVQPGQE-
------HPVWDQQGPGYS-GYGGPGSLGVDPRGRV-------------------------
-------------------------------------ALDPNRIPDF--------PAQTE
S------DQDATSDRSQDSLSFLHQVSSERSEPRSGTQSEQRNSLEKLAPNFPMALETFR
LMGELIGLYVELKENLKDLDEEKAGQTDREKIQYLFTLMVKKILLPDLQEQM-KTLKALP
KEVHQEKAKVEKVQRLLEGDGEQVAGEEL--KA--GQLAL-QLGLL-RITVTDIEKELAD
LRDSQEQG-KAAMENSVAEAS--LYLQDQLDKLRTIMESMLASSSTLLSLSIT--PHKPL
TILAPSQIHPEATCPACSLDLSHQVSTLVQRYEQLQEMVSNLAASRPSRK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHWQKQKDIDV-----------------
-----------------LYQRLEKLEKEKANRKHLQMEIEVKADKSALASKVSRVQLDAT
TEQLNHMMQELMAKMSGQEQDWQKLLDKLLAEMDM-KLDRLELDPVKQALEDRWKSLREQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGRIIPVTPVGHALP
GHR--SIRPYTVFELEQVRQQSR-NLKLGSTFLPRGDQSAMEQSVGRL--------RTMH
SKMLWD----IEKVQI-HFGGSVKTSSQMIRQLLQAHCLSSPCYKRGPN-SADHTCSTMA
RRCGGSHTVTYPYRR-NRLQHPSQALYAPEEIRI----AMKHAEVDLLGLDGHIYKGRMD
TRLPGILTKDSEYSHSPEALQSPLVGSQG-HLL--------------------L------
HRSCPSL-------------FP-APKCSHVSRGPQVS----VFRDR-----MAVQPQLIT
WHVAAPSFLA--SLHPQATAATFPGLHSQ--HHPRQPLPPL--LQS----------SAKR
RT-

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------------MENSVSEAS--LYLQDQLDKLRTIIENMLSSSSTLLSMSMT--PHKFT
GTTVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSSLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLEKEKADREHLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPVKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETSVTGQVLSMTPMVPSMP
GHR--SIRPYTVFELEQVRQQSRSNLKLGG-SLSRGDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHAQCLSHPCYKRGLE-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDKVDILGLDGHIYKGRMD
TRLPGILAKDASGMPKSKSRQLQQLQQLQ-------QL------QQLQQLQQGQHGRPHN
H-RQPSL---G--------LPPFRPLSAQMLTDSNAV-SSGQKKDRPVSSE-GRLSQSIM
AHSLGPTEMA--GLQGS-----PSGLKVH------MEVSPR--EEMEEPTRGPRSTAAH-
---

---------------MSFSLTFTELVNVAI--PQCGMVNFKALHLLLHGILEHIHMADLK
KVLSGDEDFLQT-SQVVV--------------MPREGDA----Q-----------PILSP
MKRLSNVFDHVVNRIDKIENQL----AMLQDLPS--------TTQLLEG---------SQ
GTAQPMQDLWHLIKLRKMVEGNEEATAKSIQTLQDLLTDLYALKVTVEDLR-----KDVD
MLKEMFEKV-HPERLDLFSEDLKTQNRQMIILKREM--------------DVVLWSG---
LHEAMFNSMSGGRGAGSSTWGAGQALLPQVAGSLELELSNTLQAVAPP-------LPAAI
AQT--QNLEEVSHTHVTEPLQGPRLLQASWHSDVQLPLPDQE-SVQALPSSSAKGTGQPQ
VLTPGPGPGPGPA-------------AGSSAG----PAA--------RSSAGP-------
--------ATGSSAG---------------------------------------------
-----------------PA--AGPAAGPAAGPAT-------------------ALGP-EF
QS--MATL---A----PPVIPGLIPPPLV-----NFGLGTGL------------------
----------------------------------LPF-WAEGLVPPSTSPSGPQQSSQLP
PSRAPP----PAREFGSAWPSSLQPFHLLRGEAYQ---LPMVEEKGEKYYTHYVR-----
P---TQ---EGAPKDGAPKEK---------------------------------DGVP--
------------------------------------------------RDKAP-EVRSKG
PKSALHRLRNTVAAATAAAAAYAA-AATSAARTARAAAKVIDDAPATKMATEATTMAASG
PLGVFADILGAGSSRG-----ALDFATF-----------------GERHED---------
---LLADYEIVSPPHTLGLA-----LSQAMLAASQAMS---------------SEDK---
--------------------------------------------KKAVKYS-----MSHI
A--------------------------------------QMPVRHDTLKEEFAQLSS---
-------------------------------------NVQ--------------------
---QRFDYL----GP--SRLGMAVDLLEEK-I-----------SNLEKSRVKEEELERIW
GAQV------------------------------DAM-KDHYIVLDRA----------VE
KIQTRLGDLK-LLQAQVRSLEQNKVNKSTMEQE---LKEKADRSALASKANRADLET---
------------------------------------------------VVTELNSMIQGM
LLKVSTHEDDWKKSVKQ----LRKDMGAKLVP-SDLDALKKEVADIWQAVRKLMIEGFRL
DPDRAA-GFKRQLFERVKCI-----SCDRQVEIMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
R----------------------------AH-----------LL--------------SR
L--------------------RPASANTYEY---------LQRQH--LREHH--QL----
-------------Q-FQDL---------SIPEEHFKPQGSYQDWGDG-------PRND--
PNVKLKSYNLSTLYPYGDPQVIDY-----DTAEVDILGVDGILYKGRMTSQTGTRLLATK
EKEPAA------------------VKTPC-------PP----------------------
-------------------------------------------------GQSL----C--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRSSALVGAVYPP-LGPRA-ST--SS----------TA
---TG--T-PT-----------------A--ALAR----PPSL--QPLTLLP-----PLI
PPSRD--P---------------------------QQTPEFTR-----------------
------------------------------------------------------------
-------------------------------HVRS-------------------------
-----------PHL----------------------------------------------
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---

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------------MENSVVEAS--LYLQDQLDKLRTIIENMLTSSSTLLALSMT--PQKSL
SMLAPGQIHPEATCPACSLDLSHQVSTLVQRYEQLQEMVNNLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNVTTSNLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEKEKANREHLQMEIDVKADKSSLASKVSRVQFDAT
TEQLNHMMQELMAKMSGQEQDWQKLLDKLLAAMDM-KLDRMELDPVKQALEDRWKSLREQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRALEIPVTGQIIPVTPVGQALP
GHR--SIRPYTVFELEQVRQQSR-NLKVGG-TFPRGDQSVMERSVGRL--------RSMH
SKMLLD----IEKVQI-HFGGSVKASSQMIHELLHAHCLGSPCYRRVPD-SVGYTYSTMA
RHCGGSHTLTYPYRR-NRPQHLPQGLCAPEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILVKDTLG----------------------------------ITKYKPKQSQPHR
H-RQQSLKDAS--------QLPSRPQSARTSAGNNSV-SSREHKDRPVSSE-GRLAQSDM
VHPPCPEDDV---QGGS-----PLGLEMK------LAKSPE--EGLEEPTRGPRSGPA--
---

---------------MSFSLTFTELANIAV--PQRGVLNFKALHLLLHGILEHIHMAELK
K------DFLQT-SQAVI--------------MPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKLENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHAFQVTITALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNWKMVALQQEVASLQNKFKTIPKTEDMVLWSG---
LHDTMFASEI-----G----------------SSPLD---LWQSVEQL-------PEAAL
AQT-TEYLEATHAIQVSEPVQNPQLLQTVWHYEVPELLPEGS-SAQAISLSRAQEPAQLP
ALT--PESALGRTT---EFAP--GPAPGTEPVPGLELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPVLGPVP-------------------APGA-Q-
-----------------PPPPGDWPALPRHWPLPQDWPRVGS------------------
----------------------------------WPL-WDLGVLLPTQ----------PQ
PSRAPP----PATEFGSLWPRPLPPYQSRQGEALQ---FSAVQVKGEENDVPSLR-----
G---LR---ERARKDGAPKDR-------------------------TRKDGVPKDTGGKD
VDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRDGKDGDPKDRVGKDGAPKEAQPKA
PQSALHRLKTTAAIAAAAAAAYAT-ATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAR
PLGVFADVLGAGPSRG-----ATESQIL-----------------GDDSEI---------
-------YEILSPSYSAASIGPDPALSQAMVAAKQAMS---------------PEDK---
--------------------------------------------KRAVKYS-----MSHI
A--------------------------------------QIPVKHDSLKEEFAQLSC---
-------------------------------------NLN--------------------
---QRLSYLANMGGP--SSLGTTVDILQKK-I-----------GSLQKSRLKVS------
--VS------------------------------EMM-KDCYITLEKA----------VE
NLQIRMDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRVDLET---
------------------------------------------------VALELNEMIQGV
LFKVTIHEDSWKKAMEE----LSKDVNTKLVH-SDLDPLKKEMEEVWGIVRKLLIEGLRL
DPDSAA-GFRRKMFKRVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SQ
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-LQDL---------GIQE------DCQQDWGDG-------PQNA--
TSLKCKSCNLLTLYPYGDPHVIDY-----DSAEVDILGMDGILYKGRMNSQRGAQPLA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGAICPP-LCPRS-SA--CS----------AA
---SG--P-HP-----------------T--MPTR----PPSL--PPLPLLP-----PLI
PSLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVG-----------------------------------------
----------------RKPPEEPANP----------------------------------
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---

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---------------------------------NNLIKKKKEVAEIWQAVRKVMMEGFRL
DPDHAV-GFKRRLFERVKCI-----SCDRRMEIMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
R----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQQ-Q--MREHQ--QL----
-------------Q-FQDL---------SIPEERFKPLGSHQDWSDG-------PRND--
ASLKLKSCNLSTLYPYGDPQVIDY-----DTAEVDILGVDGILYKGRMNNQTGTQPLATG
KKEPAA------------------VKIPC-------PP----------------------
-------------------------------------------------GQNL----C--
-----------------D------------------------------------------
------------------------------------------------------------
-----------H----------VHSSALVGAIYPP-LGSCT-SI--TS----------TA
---SG--T-PT-----------------I--PLAR----LPSL--LPLTLLP-----ALI
PSPRD--P---------------------------QQASEFTR-----------------
------------------------------------------------------------
-------------------------------HLRS-------------------------
-----------PHLE---------------------------------------------
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---

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------------EDHCELNASLGLQSEFQLDKLRTIIENMLTSSSTLLSMSMT---HKPI
ANLPPGQIDPDATCPACSLDVSHQVSMLVQRYEQLQDMVSNLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEM-----------------
-----------------LYQGLEKLEKEKADREHLVMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLAEMDS-KLDRLELDPVKQLLEDRWKSLRLQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETSVTGQVIPVTPMGPGMP
GHR--SSRPYTVFELEQVRQQSR-NLKMGG-NFPRNDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSHPCYKRGAD-TADYTYSTVP
RRCGGSHTLTYPYRR-NRLQHLT----PLEEMQI----AMKYDEVDILGLDGHIYKGRMD
MRLSGILNKDAPGTMKPKP--------------------------------KTQQPRTH-
----RQHSISS--------QPPSRPQSAHTLANNSA---SSRQKNRPVSSE-GRFTQSSL
MHASLPREIV--NLQGS-----HQGLDMH------MNMPPG--EGPEEPTRGPRSTAAH-
---

---------------MSFSITFTELVNVAI--PQCGVVNFKALHLLLQGILEHIQIAELK
KVLSGEEDFLQS-SPAVF--------------IPREGDA----Q-----------PVINP
MKRLSNIFDQVVDRIEKIESKL----AEMQDIPT--------TSQLVED---------SY
GDKRPAEEMWNNIKIQKRIEGNEKATEKFTRTLQDLLTDLHVLKDSVETVQ-----KDVD
TIKFIFEKV-NPQKLELLGDDLKTQSRKLGALQREVVTLQNKVRAVPQPEEMVLWSG---
LHEAMFSPEQ---------------------QKLEVEPSGVWQSMVSL-------PGSLL
EQP-----EDAGYIHI--PIHSATPVPTMVQLGTTGALREDD-LTRAVELADSQRPEWAQ
ASVSQTQ----SLR---QTAP------F------------------------P-------
--------GPGPVLG---------------------------------------------
-----------------PVP--GPVLGPGPVPVPGPGPGPGPGPGP-GPGL----VP-VP
GPVPGFVP---GPDFMPVYGPRLGMATPSAWALPRGLARGNF------------------
----------------------------------WPI-WGIGPYQPGQGPLRPMG----P
MPRVPF----PAMGSDISWTQPLPQG-----T-QW---YPDIEERGPEYEEQYPE-----
G---YQ---EEMPMDEAPQEEMAVYGALEEEIPTEGAPQDGIPKGRAR-ERISKEKVPKY
RTPKERVSY-----HKASKDVNAEDSDTKDEAPEVKVLKKVVYKDRPQKDKAQ-EPRRKG
PSSAIKKLRSAVATAAAAAAAYAA-HANSAAQLAKDAVKAIQDVPANQMATKAALIASSG
PLGAFADFLGAGFDHG-----ATSNIPF-----------------VEGEV----------
EEF----PEEF-AAPF-NPFTSKPVLSQAMINAMQATS---------------PEEK---
--------------------------------------------KKAVQYS-----MSHI
A--------------------------------------QMPSRHNSLKEEFTNLST---
-------------------------------------TLN--------------------
---QRLNYLANMGSS--GVLGNTVNVLEEK-I-----------INLQKARLQEEELERVW
GHQI------------------------------DTM-KSHYMVLDRA----------VE
RLQIRMDDLK-ILKAEIERLDLVKADKNVMDLE---LNEKANRDALASKANRVDLET---
------------------------------------------------VAMELNEMIHSM
LLKITNYESDWKKALKH----LRKDLNTKLVQ-SDLNSLKKDVEEVWKVVRKLLLEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TH-----------GL--------------PR
I--------------------RPASANSYEY---------LQRQL--IREQQ--QQ----
-------------LHFQNF---------GVHEEGQ---GFQKDWGDG-------PRNE--
NILKHKSHDLSTLYPYGDPELMNY-----DTAEVDILGVDGVLYKGRMSSQFGTRT---G
EKDIAA------------------LG----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------PRT------------------S
---IT--SATN-----------------T--TTAR----PPSL--PPVPQLP-----PLI
PVSRD--T---------------------------QEAPGSAK-----------------
------------------------------------------------------------
-------------------------------RLKS-------------------------
-----------PRL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---

---------------MSFSVTYTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTIKALR-----KEVD
MLKNMFDKV-HPERMDIFAEDFKIQNRKMIALQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFTSEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEDSSSAQAVSLSSAQEPAQPP
ALT--PESAPGRAT---AFAP--GPAPGTEPVPGPELGLEL---ES-VPALGP-------
--------VPGPTVT---------------------------------------------
-----------------PGS--LPAPWPMLGPAP-------------------APGA-Q-
-----------------PLPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRSGKDGAPKDRGGKDGAPKDRAHKDEVPKDRGSKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATTATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASISPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLANVGGS--ASLGTTVDMLQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------QAM-KDRYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PPPR---
-------------------------------------------C--------------PG
W--------------------RPASANSYEY---------LQR------EQQ--RL----
-------------Q-CQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTVKALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNRKMISLQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFASEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLLEDSSSAQAVSLSSAQEPAQPP
ALT--PESAPGRAT---AFAP--GPAPVTEPVPGPELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPMLGPAP-------------------APGA-Q-
-----------------PPPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRGGKDGAPKDRGGKDGAPKDRAHKDEVPKDRGGKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASISPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLANMGGS--GSLGTTVDMLQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------QAM-KDRYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDKWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQH--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSV-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KDLSGDEDFLQT-SQVAI--------------VPREGDA----Q-----------PILNP
MNRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-HPEKMDIFAEDFKIQNRKMVALQREVASLQNKFKTIPKTEDMVLWSG---
LHDAMFTSEI-----G----------------SSQLD---LWQSVQQL-------PEAAL
VQT-TEYLEATRAIQVSEPVQNPQLLQTMWHYEVPELLLEGS-SAQAVSLSRAQEPAQPP
ALT--PESAPGRAT---EFAP--GPAPGTEPVPGLELGLEL---EP-VPTLGP-------
--------VPGRSVT---------------------------------------------
-----------------PGS--LPAPWPVLGPVP-------------------APGA-Q-
-----------------RPPPGGWPALPRRWPLPQGWPRVGS------------------
----------------------------------WPF-WDLGVLRPTQ----------PQ
PSRAPP----PATEFGLVWPRPLQPYRSHQGEALQ---LAAVQVQGEENDVPSLR-----
G---LR---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPQD----------RGGKDGAPKDRAHKDEVPKDRGGKDGAPKDRVGKDGDPKEAQPKA
PQSALHRLKTTAAIAA---AAYAA-AASSAAQAAKVAAQSVKDAPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQVL-----------------GDDSEI---------
-------YEILSPSCSAASIGPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRCS-----MSHI
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------DLN--------------------
---QRLSYLANMGGP--SSLGRTVDILQKK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------EIM-KDRYITLDKA----------VE
KLQVRMDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRVDLET---
------------------------------------------------VALELNEMIQGM
LFKVTIHEDSWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEIWKIIRKLLIEGLRL
DPDSAA-GFRRKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-LQDL---------GIQE------DCQQDWGDG-------PQNA--
TSLKCKSCNLSTLYPYGDPHVINY-----DSAEVDILGVDGILYKGRMNSQSGAQPSA-V
AKELAA------------------AKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGTICPP-LCPRS-SA--RS----------AA
---SG--P-HA-----------------T--MPAQ----PPSL--PPLPLLP-----LLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------LHIASPVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------RKDGEPVPKKLLQ
RVDE-------LEKLIRERD-----------KFLEIVSWKLRAIPDAEEATMVTWEE---
LEQAVT---------------------------------GGRMASQM-------VSESST
RLP-----RRKGQ--GSM--TSNDK-IPSGAST------KHPSIDEAIASA--SGFGADE
T--SGTSGIGYSSEGVTGREQSKGASAT--GFPGREEHSRA---RE-EAGLTK-------
------------HRPQLREESDRRRAGE--------------------------------
--QHGLAHLRRDER--------DAHLGPVYQDVSSATD-----------QHGGVHVS-QG
QIYA--RPDQHG-----LGP---LGMSQPASLQPSTYAHGAVPLAVGQ------------
----------------------------------------LGVTPPGMDEQELVLAGMAQ
-SDAVPPLVSGRDQQGLGLPGTDQPGMVPLGTYQHGVILPGIDQRGIKQAGMDESGVGPL
GT--DQ---HGLVPLGVDQHGFVIFGMDQQGL--------------------LSPGLMQV
AA--DQQGF------------------------------------VQPSLGTSGFIQPGT
EQHETIQP--------SAGQPALV--QPSIGQPGL------VQPGAGQPGLVQPGAGQPG
LVQPGAGQPGLVQPGAAGQPGLVQPGAG---------QPGLVQPGAGQPGLVQPGA GQPA
SVQPGAGQPGLV QPGG-------------------AGQPGLVQPGAGQPGLVQPGAA---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------GQPGL VQPGAGQPASVQPGAGHPGLVQPG---------------MYQQG
LVQPSAGQPG-LVQP--------GAAG---QPGLV QPGAA---------GQPGLVQPGAG
-QPGLVQPGAA-------------------GQPGLVQPGAG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QPGLVQPGAGQ--PGLVQPGTGQP
GLVQPGAGQPGLVQPDTGSHGFFQ-----PGVSMPGLVPPGTYPPGLVQPGGYPHGLVQS
GAYPRGFMQPHR------------------------------------------------
-------------------------------------------------SRGLVQPVI--
-----------------D-QHWLR------------------------------------
-----------------------QSGTD--------------------------------
--------------------QGLIPPGTELHGFPTYHADPRSFI--SPRP---YQHGVAP
---PGRDQYGR-----------------VSPLVASQGLASPGI--DREGLVP-----RET
YQQGLMRPGP--DQRG--PKPLRTGVGSARQDQQHLEAPEPEQ--HDRAFC---------
------------------PDSHGPGYQGVDQYVEV-------------------------
-------------------------------------GLDPNEIRGS--------VRPGV
SVQTSP-SQDAPFLRSTRSLDYLYRG----LSERSDVQGEKRDSLDKLAPSFPMAVETFR
LMGELIGLYLELKENVKDLDDEQAGQTDLEKIQYLLTLMVKKSIPADLQEQL-KTLKALT
KEVRQEKAKLEKVNRILEGEEEQETGKEV--NA--GQLSL-QLGVL--VTVADIEKELAE
LRESQERG-KVSMEHSVSEAS--LYLQDQLDKLRTIIENMMASSSTLLSMSMSAAPHKLP
TTLAPSQIDPAATCPACSLDLSHRVSTLVQRYEQLQDMVSSLAASRPSKK--A---KQQS
QDEELLGRVQSAILQVQGDCEKLSIITGNLIEDHRQRQKDIEV-----------------
-----------------LYQGLEKLQKEKANREHLELEINVKADKSALAAKVSRVQFDAT
TEQLNHMMQELVAKMSGREGDWQKMLDRLLVQMDN-KLDRLELDPVKQSLEDGWKSLRLQ
LK-ERSPLYQVDEAAAMRRQLL-------AXXXXXXXXXXXXXXXXXXVIPLTPVGPGLP
GHR--SIRPYTVFELEQVRQQSR-NLQLGSAAFPWGNLGQTERSVGRL--------RSLH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLRSQCLGCPCYRRXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXX----XXX--XX----XXXXXXXXXX---XXXXXXXXX
XX---XX-----------------XXXXX-XXXXXXXX------XXSGIKHKAKQSRPHV
H-RQQSLSDSG--------QLPSRSQSAQMLAGNDSERQ---------------------
------------------------------------------------------------
---

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------------MENSVSEAS--LYLQDQLDKLRTIIESMLGSSSTLLSMSIT--PHKST
ACLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQVISVTPIISSMP
GHR--SVRPYTVFELEQIRQQSR-NLKLGS-SFPRVDMSQMERSVGRL--------HSMH
SRMLMD----MEKVQV-HFGGSVKASSQMIRELLHTQCLSHPCYKRGAD-TADYSYSTVS
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKDAPGVTKHNKAKLQQLQQLQ----QLQQL------QQLQQLQQAQHARPHA
H-RQPSLGNMI--------SPPSRPQSAQMIADSKAV-PSGQKKDRPVSSE-GRLLQSNV
SHSSIPTDIA--SLQGS-----QQGLNMH------IDVPPG--EGLEEPTRGPRSTAAH-
---

------------------------------------------------------------
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------------MENSVSEAS--LYLQDQLDKLRTIIESMLSSSSALLSLSIT--PHKSL
GTLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVTGLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLEKEKANRDHLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQTLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQVLSMTPIIPSMP
GHR--SVRPYTVFELEQIRQQSR-NLKLGS-SFPRGDLSQMEKSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHSQCLSHPCYKRGAD-TTDYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKDAPGMAKHNKAKLQQLQQLQ----QMHQM---------QQLQQLQHARPHV
H-RQPNMGNLG--------MPPSRPQSAQMLADSNAV-PSGQKKDRPVSSE-GRLLQAN-
----IPTDMG--SLPGS-----QPGMNLQ------MDMPPG--EGMEEPTRGPRSTTAH-
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-DPERMDIFAEDFKIQNRKMIALQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFTSEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQISEPVQNPQLLQTVWHYEVPELLPEDSSSAQAVSLSSAQEPAQPA
ALM--PETAPGWAT---AFAP--GPAPGTEPVPGLELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAHWPLLGPAP-------------------APGA-Q-
-----------------PPPPGGWPALPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLSVLQPTQ----------PQ
PSRAPP----PATEFASVWPQPLHPYQSRQGEDLQ---LTAVQEKGEENDVPSLR-----
G---LQ---ERAHKDGAPKDR-------------------------TRKDGVPKDRGSKD
VDPK--------------------DRGGKDGAPKDRGGKDGAPKDRAGKDGDPKEAQLKA
PRSALHRLKTTAAIAAAAAAAYAA-AASSAAQTAKAAATLVKDAPATRMATIATNTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASIGPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLNYLANMGGS--ASLGTTVDILQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------EAM-KDRYVTLDKA----------VE
KLQIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLET---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNMKLVH-SDLDPLKKEMEEVWKIVRKLLMEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMLTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLVTIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSA-V
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPA-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEERANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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------------MENSVVEAS--LYLQDQLDKLRTIIENMLTSSSTLLALSMT--PQKSL
SMLAPGQIHPEATCPACSLDLSHQVSTLVQRYEQLQEMVNNLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNVTTSNLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEKEKANREHLQMEIDVKADKSALASKVSRVQFDAT
TEQLNHMMQELMAKMSGQEQDWQKLLDKLLAAMDM-KLDRMELDPVKQALEDRWKSLREQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRALEIPVTGQIIPVTPVGQALP
GHR--SIRPYTVFELEQVRQQSR-NLKVGG-TFPRGDQSVMERSVGRL--------RSMH
SKMLLD----IEKVQI-HFGGSVKASSQMIHELLHAHCLGSPCYRRVPD-SVGYTYSTMA
RHCGGSHTLTYPYRR-NRPQHLPQGLCAPEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILVKDTLG----------------------------------ITKYKPKQSQPHR
H-RQRSLKDAS--------QLPSRPQSARTSAGNNSV-SSREHKDRPVSSE-GRLAQSDM
VHPPCPEDDV---QGGS-----PLGLEME------SAKSPE--EGLEEPTRGPRSGPA--
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-DPERMDIFAEDFKIQNRKMIALQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFTSEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQISEPVQNPQLLQTVWHYEVPELLPEDSSSAQAVSLSSAQEPAQPA
ALM--PETAPGWAT---AFAP--GPAPGTEPVPGLELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPLLGPAP-------------------APGA-Q-
-----------------PPPPGGWPALPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLSVLQPTQ----------PQ
PSRAPP----PATEFASVWPQPLHPYQSRQGEDLQ---LTAVQEKGEENDVPSLR-----
G---LQ---ERAHKDGAPKDR-------------------------TRKDGVPKDRGSKD
VDPKDR----------GGKDGAPKDRGGKDGAPKDRGGKDGAPKDRAGKDGDPKEAQLKA
PRSALHRLKTTAAIAAAAAAAYAA-AASSAAQTAKAAATLVKDAPATRMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASIGPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLNYLANMGGS--ASLGTTVDILQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------EAM-KDRYVTLDKA----------VE
KLQIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLET---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNTKLVH-SDLNPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMLTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLVTIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSA-V
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEERANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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-----------------------------------------------------MAVETLR
LIGELISLYLELKEQLKDLDEELAGQTDFEKIQYLITMIVKKTIPQDLAEQL-KSLKTLN
KEVRQDKAKLEKIQKFVDSAADTTGGKEV--KP--NHLSL-QLGIL-RVTVSDIEKELNE
LRESQDRG-KATMENSVSEAS--LYLQDQLDKLRTIIESMLSSSSTLLSMSIT--PHKST
ACLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEM-----------------
-----------------LYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQVISVTPIISSMP
GHR--SVRPYTVFELEQIRQQSR-NLKLGS-SFPRGDMSQMERSVGRL--------HSMH
SRMLMD----MEKVQV-HFGGSVKASSQMIRELLHTQCLSHPCYKRGAD-TADYTYSTVS
RHCGGSHTLTYPYRR-NRPQHQS----PLEEIQI----AMKH-EVDILGLDGHIYKGRMY
TRLPGILGKDAPRVTKHNKAKLQQLQQL-------------------QQLQQVQHARPHT
H-RQPSLGNMI--------SPPSRPQSAQMIADSKAV-PSGQKKDRPVSSE-GRLLQSNV
SHSSIPADIA--SLQGS-----QQGLNMH------IDVPPG--EGLEEPTRGPRSTTAH-
---

---------------MSFSVTFTELVNIAV--PQCGVVNFKALHLLLHGILEHIHMAELT
KVLSGDEDFLQA-SQVVL--------------VPREGDA----P-----------PILNP
MRRLNNVFEHVVNRIDKVESQL----ALMQDLPS--------TAQLLEG---------SK
GASRPAQDLWHLIKLRKMVEGNEEATAKSMKTLQDLLTDLYALRVTTETLR-----KDVD
MLKDMFEKVMHKEKMKIFSDDLRAHNQKMIALQRDVSSLQDKLHAIPKSEDMVLWTG---
LHEAMFTPEGGE---------------------QAA---DWGGTTEPL-------PVAAM
AQT-SKLLEAAPSIHVTEPFQSPKPLQTIYSYEGLGHLQEES--TSSVSLSGTQEQGQPL
VLK--PG---------------HVPEPGSAPE----PGLEP---EP-TTALGP-------
--------MPGPSVT---------------------------------------------
-----------------PEF--RPAPWPAFGPGP-------------------APGI-Q-
------------------------PPSRRGWPVP-------T------------------
----------------------------------WSF-WDLDFLPPTQ------------
RSRAPP----PATELGSAWPPPLQLHPA-----RQ---LSAVEEKEEEYYASYLK-----
F---FQ---DRATKDAARKEG-------------------------T-----PKGRA---
------------------------------------------RKEGAPKDGAPGEAHHKG
ASSAIQQMKTTATAAAAAAAAYAA-AARSAARAARVAAKAVRNAPATKMATLATVVASSG
PLGAFADVLGAGSSRG-----ATDPLLE-------------------DSE----------
------GYEDFSLSYSVVNLTPTTALSQAMLAAKQAET---------------PEDK---
--------------------------------------------KEAVRYS-----MSHI
A--------------------------------------QMPVKHDTLKEEFAQLSS---
-------------------------------------ELN--------------------
---QRLTYLANMRGS--SSLGTTVDTLQEE-I-----------GSLQKSRLKEEELERIW
GSQM------------------------------EMM-KGHYLMLDKT----------VE
KLQFRMDEFK-TLQAQIRTLEMNKVNKSMMEEE---LREKADRSALAGKANRADLEM---
------------------------------------------------AATELHEMIQGM
LFNVTTLQDDWKKAMEQ----LQKDVSTKLVH-SDLDSLKREMEEVWKVVRKLLIEGFRF
DPDSAA-GFRKKLFERMKCI-----SCNRPVEMMTS------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SH
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-LQDL---------GAQEGSM---DSQQDWGDG-------PQND--
ANLKHNLCNLSTLYPYGDPHVIDY-----DTAEVDILGVDGILYKGRMNSQSRAQPLTTM
EKELTA------------------VKAPR-------PP----------------------
-------------------------------------------------SRRL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------C----------TRSSALFGAICPP-PGPRT-SA--RS----------AV
---SG--P-HL-----------------M--MPAR----PPSL--LPLPLLP-----SLV
SPPGD--P---------------------------QQAPGPTR-----------------
------------------------------------------------------------
-------------------------------SSRS-------------------------
-----------LRLEFQAS-----------------------------------------
----------------MQPPKEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSVTFTELANIAI--PQCGVLNFKALHLLLQGILEHIHMAELQ
KVLSGDEDFLQP-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKIENQL----ALLKDLPS--------TAQLLEG---------SQ
GTGRPAQDLWHLIKLRKTVEAHDEALAKSMQTLQDLLTDLHALQVTVKALR-----KDVD
MLKNMLDKI-HPERMDMFAEDFRIQNRKMVALQQEVASLQNKVQTIPKTEDMVLWSG---
LHDAMFTSEV-----G----------------SSHLDFPPLWQSVEQL-------PEAAL
AQT-TEYLEATRAIHVSEPIQNPQLLQTVWHYEVPELLPEEP-SAQATSLSSAQESAQPL
ALT--PESSPGRTI---EFAP--GPEPA--------PGLEP---EP-VPRLET-------
--------VPGPSVT---------------------------------------------
-----------------PGF--LPAPWPV----P-------------------APGA-Y-
-----------------PSPPGDWPALPRRWPLPQGLPGLGS------------------
----------------------------------WPF-WDLGILRPPQ----------PQ
PSGAPP----PTTEFGFMWPQPLQPYQSHEGEALQ---VAAVQEKGEENDVPSMR-----
D---SR---ERAHKDGPPKDR-------------------------ARKVGIPKDGGGKD
VAPKDRGG----------------------------------------KDGAPKEAQPKT
PQSALHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKVVKDAPATKMATFATDMASAG
PLGVFAHVLGAGPARG-----ATESQDV-----------------DDDSE----------
---------ILSPSYSAASIGPDTALFHGMLAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHI
A--------------------------------------QMPVRHDSLKEEFAQLYF---
-------------------------------------NLN--------------------
---QHLTRLASMGGP--SSLGATVDILQEK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------ETV-KDHYIILDKA----------VE
KLQIRMDEFK-NLQAQVKRLEMNKVNKSTMEEE---LREKADRSALAGKANRADLET---
------------------------------------------------VALELNEMIQDM
LFKVTIHEDNWKKTVEQ----LSKDMNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--QL----
-------------Q-FQDL---------GIQE------DVQQDWGDG-------PQND--
TSFKCKSCNLSTLYPYGDPHVIDY-----DSVEVDILGVDGILYKGRMNSQRGAQASA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGTVCPP-LHPHT-SA--RS----------SA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLT
PPLRD--P---------------------------QQAPGPTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANL----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSVTFTELANIAI--PQCGVLNFKALNLLLQGILEHIHMAELK
KVLSGDEDFLQP-SQVVI--------------APREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKIENQL----ALLKDLPS--------TAQLLEG---------SQ
GTGQPAQDLWHMIKLRKTVEAHDEALAKSMQTLQDLLTDLHALQVTVKALR-----KDVD
MLKNMLDKVIHPERMDMFTEDFRIQNRKMVALQRELASLQNKVQTIPKTEDMVLWSG---
LHDAMFTSET-----G----------------SSHLDFPPLWQSVEQL-------PEAAL
AQT-AEYLEAARAIHVSEPIQNPQLLQTIWHYKVPELLPEEP-SAQAASLSSAQESAQPL
ALT--PETSPGHAI---EFAP--GPEP----V----PGLDL---EA-VPKLGP-------
--------VPGPSVT---------------------------------------------
-----------------PGF--LPAPWPVPGPVP-------------------APGA-Y-
-----------------SSPPGDWPALPRLWPLPQGLPGLGS------------------
----------------------------------WSL-WDSGILRPPQ----------PQ
PSRAPP----PATEFGFMWPQPLQPYQSHQGEALQ---VAAVQEKGEENDVPSMR-----
G---PQ---ERAHKDGPPKDR-------------------------AHKVGIPKDGSGKD
VAPKDRGG----------------------------------------EDGAPKEAQPKT
PQSALHWLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKVVKDAPATKMATTATDMASAG
PLGVFAHVLGAGPARG-----ATESQDV-----------------DDDSE----------
---------ILSPSYSAATIGPDKTLSQGMLAAKQATS---------------PDDK---
--------------------------------------------KRAVRYS-----MSHI
A--------------------------------------QMPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QHLTRLGRPGLA--LG---------------------------RAQGSGEEELERIW
GNQI------------------------------ETV-KDHYIILDKA----------VE
KLQIRMDEFK-TLQDQIKRLEMNKVNKSTMEEE---LREVTLWEAEAGRSQGQEIET---
------------------------------------------------ILANMGVNSLTI
L--SFLPL-----------------GCWQLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRKKLFKRVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASTNSYEY---------LQRQQ--MREQQ--RL----
-------------Q-FQDL---------GIQE------DFQQDWGDG-------PQND--
TSFKYKSCNLSTLYPYGDPHVIDY-----DSVEVDILGVDGILYKGRMNSQRRAQASA-I
TKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSSLFGAIS---LHPHT-SA--RS----------SA
---SG--P-HP-----------------T--MPAQ----PPSL--PPLPLLP-----PLI
PPLRE--P---------------------------QQAPGPTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------LHFESRVS-----------------------------------------
----------------RKPPEEPANL----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPESSHSLLSARS-----SLNTPYLPAPKEAPKGAPREKRRGVGRVPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLLKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQVLDSA--RGLGPDQ
TA-SGSGGATHPSEAVISREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSGEKLTS----------------------------
------TLSRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGQ--GGLVQPGV-DQLGMVQ-------------------PGADLHGLVQPGMDQ--
------DQHGLVQSGTGQGGLVQPGVDQPGMIQPGADQHGLVQIGAYPPGLVQPGMD-QH
GLIQSGAFPSDWI-----------------------------------------------
-----------------------------------------------------QPD----
----PGTYPHGLVQAGADPRSLVQPGIDQRGLVQLGADQYGFV---------------QP
GIDQLGLVQRGADQQGLVQSGAVQYGVV-------------------QPGMDQHGLAQPG
T--------------------LQSSLGQPGAVQHGFVQPG---------------VDQRG
LRSL--------------------------------------------------------
-----------------------------------VQPGAVQRGLVQPGVDQRGLVPPGA
VQRGLVPSGAVQRGLVQP------------------------------------------
------------------------------------------------------------
-----GVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGAGQP
GLVQPGAGQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRDSSTFQADSTGFV--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASPGI--DQRSLVP-----PET
YQQGFMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERHDSLYRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMGGCCLPREERPLSLFSAGFIL
FFPWSQLLAVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVISRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMKQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGSRR-----RCRKE-K-------AG
CGKEDPE-----------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQPSSPEPSRSLQSVRS-----SFSISHLPAPKEVPKGAPREKRRGVGQAPSSALESQ
VKDLGGQVEDLSKQLKRVDGQVQGIATHVQHFSQASG-LDLAALEWPEEQEVGARALDRL
RTGS-----I-MKD---------------------------------AAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLT
GFS-----KRGGF--TSL--TSPEG-TLSGAST------KQPSIEQALDSA--SGLGPDR
TA-SGSGGTAHPSDGVSSREQSKVP-----SGTGKQQQPRA---RD-EAGIPR-------
--------LHQSSTSQFKSDSDRHRSREKLTS----------------------------
------TQPRRDAQ--------DARPGPVQQDLPSARD-----------QPSRVPAS-QS
QVHL--RPDRRG-----LEP---TGMNQPGLVPASTYPHGVVPLSMGQ------------
----------------------------------------LGVPPPEMDDRELIPFVMDE
-QCMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEP----------L
GM--DR---RGFVISGMGQQGLVPPGMDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHALV--QRGAYQPGL------VQPGADQRGLVRPGMD---
------------------QSGLAQ-------------------PGRDQHSLVQPGT----
------GQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQHALVQPGAYQPGLVQPGAD-QI
DVVQSGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQ---------------------
--------------------------------------RGLAQPHE-DQRGLVPPGADQR
GLVQPGADQHGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLV---------------QP
GVDQRGLVQPGAVQRGLVQPGVDQRGLV-------------------QPGAVQHGFV---
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------QPGADQRGLVQPAV
DQRGLVQPGVDQ------------------------------------------------
-----------------------------------------------------------H
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGMDQ--RGLIQPGADQP
GLVQPGAGQLGMVQPGIGQQGMVQ-----PQADPHGLVQPGAYPLGL----------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------RGLVQPGM--
-----------------D-QYGLK------------------------------------
-----------------------QPGAY--------------------------------
-------------------QPGLIAPGTKLRGSSTFQADSTGFI--SVRP---YQHGMVP
---PGREQYGQ-----------------VSPLLASQGLASPGI--DRRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPGPGE--HDQVYPDAAQHGHA-
------FSLFDSRDSMYP-GYRGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DRRGI
PAQKAP-GQDVTLFRSPDSV---DRVSSEGSEVSSEVLSERRDSLCRMSSSFPTAVETFR
LMGELSNLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQIVKRTIPPELQEQ-LKTVKMLA
KEVWQEKAKVERLQRILEGEGNQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAISRPSKK--A---KLQR
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTEHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILRKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLSSNG--------QLPSRPQSAQISAGNTSER----------------------
------------------------------------------------------------
---

---------------MSFSLTFTELADIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVM--------------MPREGDA----Q-----------PILIP
MKRLSNVFDHVVSRLDKLENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKTQNWKMVALQREVASLQNKFKTIPKTEDMVLWSG---
LPDAMFTSS-----------------------------------IEQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVSELLPEGS-SAQAVSLSRAQEPAQPP
ALT--PESALGCTT---EFAP--GPAPGTEPVPGLEVGLEL---EP-VPALGA-------
--------------T---------------------------------------------
-----------------PGS--LPAPWPVLGPVP-------------------APGA-Q-
-----------------PPPPGDWPALPRRWPLPQGWPRVGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFGSVWPRPLQPYQSRQGEALQ---LAAVQVKGEENDVPSLR-----
G---LR---ERARKDG---------------------------------A----------
--PKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKA
PQSALHRLKTTAAIAAAAATAYAA-ATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAG
PLGVFADVLGAGPSRE-----ATESQIL-----------------GDDSEI---------
-------YKILSPSYSAASIGPDPALSQAMVAAKQAMS---------------PEDK---
--------------------------------------------KRAVKYS-----MSHI
A--------------------------------------QIPVKHDSLKEEFAQLSC---
-------------------------------------NLN--------------------
---QHLSYLANMGGP--SSLGTTVDIVQKK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------EMM-KDRYITLDKA----------VE
NLQIRMDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRVDLET---
------------------------------------------------VALELNEMIQGM
LFKVTIHEDSWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFKRVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-LQDL---------GIQE------DCQQDWGDG-------PQNA--
TSLKCKSCNLLTLYPYGDPHVIHY-----DSAEVDILGVDGILYKGRVNSQRGAQPLA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGAICRP-LCPCS-SA--CS----------AV
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PSLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVG-----------------------------------------
----------------WKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSVTFTELANIAI--PQCGVVNFKALHLLLQGILEHIEMAELK
KVLSGDEDFLQT-SHVIF--------------MPREGDA----Q-----------PILNP
MKRLSNIFDHVVDHINKIESQM----SMLQSMPS--------TTQLLES---------SK
GASRPAEDLWNMIKLQKRVEGNEEATAKSMKILQDLLTDLHALKITIETLQ-----KDVD
VIKYIFEKV-NPERVDLVCEDLKTQNRKMGALQREVVTLQNKIHAVPKPEDIVLWSS---
LHEAMFTSVP---------------------ARLDLDMSNMLQAMAPP-------PEATF
AQF-----EDAGHAHVSQSIHSTIPLQTMVHFEAPGVLSEDE-SVQAIEFIGSQGLEQAQ
ASMSELG----FGS---AFGP------G------------------------H-------
--------VPGPDVR---------------------------------------------
-----------------PCF--MPAPWPTLGP----------------------------
--APGVRP---P--------------PPRGCPGPGGWPGA-T------------------
----------------------------------WPT-WDLGAFQAVVGPLGPEG----Q
MYRALP----PAMEFGSSWPHPLQHHPPKPGS-QL---LSVLEETGDEYYTDS-------
------------------------------------------------QEG---------
--------------------------TSKDGAPHDEAPKDMTHRDKAYKDKAL-EAHSKG
SRPALKKLKDTVTIAAAAAAAYAA-AANSAAQA---ALKAVKDAPASKMAAMATTTAASG
PLGAFSDVLGAASSRG-----ATNFMPF-----------------SDDGED--------V
EDLPID-SEEFSPPVF-PPITPKTALSQAMLAAMQAVS---------------TEDK---
--------------------------------------------KKAVQYS-----MSHI
A--------------------------------------QIPVRHNSLKEELTHLST---
-------------------------------------NLQ--------------------
---QRLTYLANKGSA--VKLGNTMNVLEEK-I-----------GNLQKARLQEEELERVW
GHQI------------------------------ELM-KNHYMVLDRT----------VE
KLQIQMDNFK-TLQAEIKRLEINKVDKTKIDQE---LREKADKGAVASKANRTDLEA---
------------------------------------------------VATELNEMVQSM
FLKITTHENDWKKSLKH----IRKDLNTKLVH-SDLLGLKKDVEEVWKAVRKLQLKGLRF
DPDSAA-GFRKKLFERVKCI-----SCERPVEMMSS------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------MQ-----------VL--------------SQ
M--------------------WPASANSFEY---------LQRQL--MREQQ--QR----
-------------LHFQNL---------GVQEGGL---GFQKDWGDG-------PQND--
TTFKHKSYDLLTFYPYGDPTLMDY-----DTAKVDILGVDGILYKGRMSRQFGAQT---G
EKDQAA------------------VKVSC-------PS----------------------
-------------------------------------------------TQNP----S--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VCQGSLFSAGYPS-LGPCTSIS--SA----------TS
---Q----HFA-----------------T--TLVR----PPSL--PQVPQLP-----PLI
PLPRD--S---------------------------QEAPGPTR-----------------
------------------------------------------------------------
-------------------------------HSRS-------------------------
-----------LQL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MAEGDRAWGGTGDR----VGGRVIMSWFGAAP
PDQPHIPQGA---------------------APQLLGNSDLWQISELA-------SETAV
AQT-AKDRGGGGLSHFSEAIRHPRFLETIWQYQAPGQLLEEE-SAQAALLLGAKGPDQPQ
VLEPGPGPGLALGP---RPVPGPGPSS--E----AAPKFRP---EP-APGPGP-------
--------SSGPGPVFGPGPSSGSGPVFGPGPAPGPGPAFGPGPVPGPGPAPGPGPSSGP
GPGSAPGPGPSSGPGPVPGPGPSSRSGPAFGPGP-------------------APGP-GP
VFGPGPAPELEPAPGLQPTPSGSWTVPPQGWPPPRGFPGTSP------------------
----------------------------------GPF-WGF---QPGLGPMGFPP-ARFR
GFRAPP----PAMELGSAWPRSQRSMYY-PGDMSK---LSAVSEKEEDYSSVERG-----
G---P-------------------------------------------------------
-------------------------------------------LDRAPRAEVPPGGLPKG
FWSVVQQMKPSAALTAAAAASYTSDVATSAARAAKAAAKLIRDAPATKLATVATAAATAG
PLGVLAEFLGAGPSRG-----AFPEGE-----------------------V--------E
DLLEVEDEDLLCPAYSPVFVPPDTALSKAMLAAKHATT---------------PEEK---
--------------------------------------------KKAVRYS-----MSHL
A--------------------------------------QMPVRHDTLKEELAQLSS---
-------------------------------------NLQ--------------------
---QRMTYLANMGAS--SKLGSTLDILQEK-I-----------GNLQKSRIKEEELERVW
GHQI------------------------------EMI-KDHHIVLDRA----------VN
RLQIRLDELK-VVYAQLRNLEMYKADRHEMERE---LKE-ADKSSLAGKASRADLDT---
------------------------------------------------VAMQLNEMIQGM
LFRVVANEDDWKKAVEQ----LDKDVRTKLVP-SDLDDLKKDMDEVWKVVRKLLIEGLHF
DPDNAA-GFRRKLFERVKCI-----SCDRPVEMMTS------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TR-----------VL--------------PW
L--------------------RPASANSYEY---------LQRQQ--MREQQ--QL----
-------------QKLQNL---------GAPEMGLDSLGPPQDWGDG-------PRNN--
ANLEFKPYGLSTLYPYGDPELLDY-----DSAEVDLLGVDGVLYKGRMMSKDKVRPLTSA
EKELAA------------------VKVPH-----P-PA----------------------
-------------------------------------------------RSPH----E--
-----------------G------------------------------------------
------------------------------------------------------------
----------------------ARPSALFGAISSGE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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---

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------------MENSVAEAS--LYLQDQLDKLRMIIESMLASSSTLLSLSMT--PHKPL
TVLAPGQIHPEATCPACSLDLSHQVSTLVQRYEQLQEMVSNLAASRPSRK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLLEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEK-NANREHLQMEIDVKADKSALASKVSRVEFDAA
TEQLNHMMQGLMAKLSGQERDWQKLLDKLLAEMDM-KLDRLELDPVKQALEDRWKSLREQ
LK-EHSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGQIIPVTPVGHPLP
GHR--STRPYTVFELEQVRQQSR-NLKLGS-CFPRGDQSPMEQSVGHL--------RTMH
SKMLLD----IEKVQI-HFGGSVKASSQMIRELRQAHCLSSPCFKRVPD-SADYTYSTMS
RRCGGSHTLTYPYRR-NRLQHPSQGAYAPEN-QI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILTKDPSG----------------------------------MMKYKAKQCRPRG
N-RQQPLSDNS--------QLPSRPQSAQMLAGNNSV-SSRQQQDRPVSSAVDPLAQSDM
APPPSPNLQ-----GSL-----PGELERN--T---DMLPPG--EGLEEPTRGPRSTTGQ-
---

---------------MSFSVTYTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTIKALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNRKMIALQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFASEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEDSSSAQAFSLSSAQEPAQPP
ALT--PESAPGRTT---AFAP--GPAPGTEPVPGPELGLEL---EP-VPALGP-------
--------VPGPTVT---------------------------------------------
-----------------PGS--LPAPWPMLGPAP-------------------APGA-Q-
-----------------PPPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRGGKDGAPKDRGGKDGAPKDRAHKDEVPKDRSGKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAASISPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLGRPGLA--LGR------------------------AQGSGALPEEELEIIW
GNQI------------------------------QAM-KDRYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQH--MREQQ--RL----
-------------Q-CQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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------------MENSVSEAS--LYLQDQLDKLRTIIESMLSSSSTLLSLSIT--PHKFT
NTLVPGQIDPEATCPACSLDVGHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGLERLEKEKADRDHLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETSVTGQVLSMTPVVPSMP
GHR--SIRPYTVFELEQVRQQSR-NLKLGG-SFSRGDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELMHAQCLSHPCYKRGVD-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKD--GMTKHKSKQLQQLQQLQ-QLHQLQQM------QQLQQAQQAQHARPHV
H-RQPSLGNGG--------LPPSRPQSAQMLADSNSV-PSGQKKDRPVSSE-GRLSQLNV
AHASIPTEMA--GLQGG-----PSGLNVH------MDVPPR--EGMEEPTRGPRSTTAH-
---

------------------------------------------------------------
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-----------------------------------------------------MAVETFR
LIGELISLYLGLKEQLKDLDEDLAGQTEFEKIQYLISMIVKKTISQDLAEQL-KSLKMLN
KEVRQDKAKLEKIQKFLDSAADTTGGKEV--KP--NHLSL-QLGIL-RVTVSDIEKELNE
LRESQDRG-KATMENSVSEAS--LYLQDQLDKLRTIIESMLSSSSTLLSMSIT--PHKST
AGLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQVISMTPIISSMP
GHR--SVRPYTVFELEQIRQQSR-SLKLGS-SFPRGDVSQMERSVGRL--------HSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHTQCLSHPCYKRGAD-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKDAPGVAKHNKAKLQQLQQLQ----QLQEL------QQLQQAQQAQHARPHV
H-RQPSMGNMS--------SPPSRPQSAQMLADSNAV-PSGQKKDRPVSSE-GRLLQSNL
SHSSIPTDMA--SLQGS-----QSGLNMH------IDVPPG--EGLEEPTRGPRSTTAH-
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MKD---------------------------------AAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KHGGF--TSL--TSPEG-TLSGDST------KQPSIEQALDSA--SGLGPDR
TA-SGSGGTAHPSDGVSSREQSKVP-----SGTGRQQQPRA---RD-EAGVPR-------
--------LHQSSTFQFKSDSDRHRSREKLTS----------------------------
------TQPRRN-----------ARPGPVQQDLPLARD-----------QPSSVPAS-QS
QVHL--RPDRRG-----LEP---TGMNQPGLVPASTYPHGVVPLSMGQ------------
----------------------------------------LGVPPPEMDDRELIPFVVDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEP----------L
GM--DQ---RGCVISGMGQQGLVPPGIDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQRALV--QRGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGADQRGLVWPGM-DQSGLAQ-------------------PGRDQHGLIQPGT----
------GQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQRALVQPGAYQPGLVQPGAD-QI
DVVQPGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQ---------------------
--------------------------------------RGLAQPRADHQRGLVPPGADQR
GLVQPGADQHGLVQPGVDQHGLAQPGEVQRSLVQPGIVQRGLV---------------QP
GAVQRGLVQPGAVQRGLVQPGVDQRGLV-------------------QPGAVQRGLV---
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------QPGAVQHGLVQPGA
DQRGLVQPGVDQ------------------------------------------------
-----------------------------------------------------------R
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGMDQ--RGLIQPGADQP
GLVQPGAGQLGMVQPGIGQQGMVQ-----PQADPHGLVQPGAYPLGL----------VQP
GAYLHDLSQSGTYP----------------------------------------------
--------------------------------------------------RGLVQPGM--
-----------------D-QYGLR------------------------------------
-----------------------QPGAY--------------------------------
-------------------QPGLIAPGTKLRGSSTFQADSTGFI--SVRP---YQHGMVP
---PGREQYGQ-----------------VSPLLASQGLASPGI--DRRSLVP-----PET
YQQGLMHPGT--DQHS--PIPLSTGLGSTHPDQQHVASPGPGE--HDQVYPDAAQHGHA-
------FSLFDSHDSMYP-GYRGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DRHGI
PAQKAP-GQDVTLFRSPDSV---DRVLSEGSEVSSEVLSERRNSLRRMSSSFPTAVETFH
LMGELSSLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQMVKRTIPPELQEQ-LKTVKTLA
KEVWQEKAKVERLQRILEGEGNQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDRLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILRKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLSSNG--------QLPSRPQSAQISAGNTSER----------------------
------------------------------------------------------------
---

---------------MSFSLTFTELVNVAV--PQCGMVNFKALHLLLQGILEHIHMTDVK
KVLSGDEDFLQT-SQVVV--------------MPREGDA----Q-----------PIISP
MKRLSNVFDQVVSRIDKIENQL----AILQDLPS--------TTQLLEA---------SQ
GTARPIEYLWHLMKLRKMVEGNEEAMEKSIQTLQDLLTDLYALKVTVEDLR-----KDVD
MLKDRFEQV-HPERLDLFSEDLKTQNRQMIVLKREMMSLQKKVHAIPSTEDVVLWSG---
LHEAMFTPG---------------------AAPLELELSNAWQTTEPL-------PQAAI
AQT--QNLEEVGHTHVVEPVQGPRLLQAAWHSDVQVPLPDQE-SGQALPFGSANGPGQPQ
TLIAGPGPAAGPG-------------PASGPE----P-----------------------
------------AAG---------------------------------------------
-----------------PE--PAAGPGPAAGPAT-------------------APGP-ES
QS--MATL---G----PPVMPGFTPAPLV-----TFGPGTGA------------------
----------------------------------LPF-WPKGLLQPSTSPSGALQSFQPQ
PSRAPP----SAQEFGSAWPSSLQPFQFFKGEAHQ---LPMIEEKGEKYYAQYVK-----
H---IQ---EGSPKDGAPKER-------------------------ASPDGIPKDWIP--
------------------------------------------------RDRAL-EVRPKG
PKSALNRLKNAVATATAAAAAYAA-AATSAARTARAAAKALEDTPATKMATEATTTAASG
PLGVFADVLGAGSSRG-----ALDFTTS-----------------GEKQED---------
---LVTEYETFSPPHTLDLGIRESALSQGMLAATQAVS---------------PEDK---
--------------------------------------------KKAVKCS-----MSHI
A--------------------------------------QMPMRHDNLKEEFAQLSS---
-------------------------------------DLM--------------------
---QRFNYLVDMAGA--SRLGMAVDQLEGK-M-----------NNLEKSRLKEEELERVW
GTQL------------------------------EAM-KNRYIVLDRA----------VE
KIQTRMDDLK-ILQAQIKSLEQSKVNKITMEQE---LKEKADKSALASKASRADLET---
------------------------------------------------VVTELNGMIQGM
LLKVSTHEDDWKKSVKQ----LRKDMSAKLAP-TDLDALKKEVADIWQAVKKLMIEGFRL
DPDRAA-GFRRQLFQRVKCI-----SCDRRVELMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
R----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREHH--QL----
-------------R-FQDL---------SIPEESFNPLASHQDWGDG-------PRND--
PSLKLKSYNLSTLYPYGDPQVIDY-----DTAEVDILGVDGILYKGRMN-QTGTRLLATG
EKEPAA------------------VKTPC-------PP----------------------
-------------------------------------------------GQS--------
-----------------D------------------------------------------
------------------------------------------------------------
-----------H----------VRSSALAGAVYPP-VGPRT-ST--NS----------TA
---LG--T-PT-----------------T--TLAQ----PPSL--LPLTPLP-----PLV
PPPRD--P---------------------------QQTPEFTR-----------------
------------------------------------------------------------
-------------------------------HLRS-------------------------
-----------PHLESRAS-----------------------------------------
----------------MRPVEEPTNL-TLFK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSITFTELVNVAI--PQCGVVNFKALHLLLQGILEHIQITELK
KVLSGEEDFLQS-SPAVF--------------IPREGDA----Q-----------PVINP
MKRLSNIFDQVVDRIEKIESKL----AEMQDIPT--------TSQLVEE---------SY
GDKRPAEEMWNNIKIQKRIEGNEKATEKFTRTLQDLLNDLHVLKGSVETVQ-----KDVD
TIKFIFEKV-NPQKLELLGDDLKTQSRKLGALQREVVTLQNKVRAVPQPEEMVLWSG---
LHEAMFSPEQ---------------------QKLEVEPSGVWQSMVSL-------PGSPL
EQP-----EDAGYIHI--PIHSATPVPTMVQLGTTGALREEE-LTRAVELADSQRPELAQ
AFVSQTQ----RLE---RAQA------S------------------------V-------
--------SQTQRLE---------------------------------------------
-----------------RAQ--ASVSQTQRLER---AQASVSQTQN-LRQT----AP-FP
FPVPGFVP---GPDFMPVYGPRPGMATPSAWALPRGLARGNY------------------
----------------------------------WPI-WGIGPYQPGQGPLQPMG----P
MPRVPF----PAMGSDIPWTQPLPQG-----T-QW---YPNIEERGPEYEEQYPE-----
G---YQ---EEMPMDEAPQEEMAVYGALEEEIPTEGAPQDGIPKGRAR-ERISKEKVPKY
RTPKERVSY-----HKASKDVSPEDTGTKDEAPEVKVLKKVVYKDRPQKDKAP-EPRRKG
PSSAIKKLRSAIASAAAAAAAYAA-HANSAAQLAKDAVKAIQDVPANQLAAKAALIASSG
PLGAFADFLGAGFGHG-----ATSNTPF-----------------DEGEL----------
EEF----PEEF-AAPF-NPFTSKPVLSQAMISATQATS---------------PEEK---
--------------------------------------------KKAVQYS-----MGHI
A--------------------------------------QMPSRHNSLKEEFTNLST---
-------------------------------------TLN--------------------
---QRLNYLANMGSS--GVLGSTVNVLEEK-I-----------INLQKARLQEEELERVW
GHQI------------------------------DTM-KSHYMVLDRA----------VE
RLQIRMDDLK-ILKAEIERLDLVKADKNVMDLE---LNEKANRDALASKANRVDLET---
------------------------------------------------VAMELNEMIHSM
LLKITNYESDWKKALKH----LRKDLNTKLVQ-SDLNSLKKDIEEVWKVVRKLLLEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TH-----------GL--------------SR
I--------------------RPASANSYEY---------LQRQL--IREQQ--QH----
-------------LHFQNF---------GVHEEGQ---GFQKDWGDG-------PRNE--
NTLKHKSHDLSTLYPYGDPELMNY-----DTAEVDILGVDGVLYKGRMSSQFGTRT---G
EKDIAA------------------VKVSY-------YT----------------------
-------------------------------------------------IPNL----T--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRPGSLLAPGYPP-LSPRTSIT--SA----------TT
---LH--SATN-----------------T--TTAR----PPSL--PPVPQLP-----PLI
PVSRD--T---------------------------QEAPGSAK-----------------
------------------------------------------------------------
-------------------------------RLKS-------------------------
-----------PRL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSVTFTELANIAI--PQCGVLNFKALHLLLQGILEHIHMAELK
KVLSGDEDFLQP-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKLENQL----ALLKDLPS--------TAQLLEG---------SQ
GTGRPAQDLWHLIKLRKTVEAHDEALAKSMQTLQDLLTDLHALQVTAKALR-----KDVD
MLKNMLEKI-HPERMDMFAEDFRIQNRRMVALQREVASLQNKVQTIPKTEDMVLWSG---
LHDAMFTSEI-----S----------------SSPLDFPRLWQSVEQL-------PEAAL
AQN-AEYLEATRAIHVAEPIQNTQLLQTVWHYEVPELLPEEP-SAQAASLSSDQESAQPP
ALT--PESSPGRAI---EFAP--GPEPV--------LGLEP---EA-VPRLEP-------
--------VPGPSVT---------------------------------------------
-----------------PGF--LPAPWPVPGPVP-------------------APGA-Y-
-----------------PSPPGDWPALPGRWPLPQGLPELGS------------------
----------------------------------WPF-WDLGLLRPPQ----------PQ
PSGAPQ----PATEFGFMWPQPLQPYQSHQGEALQ---VAAVQEKGEENDVPSMR-----
S---PR---ERARKDGHPKDR-------------------------ARKVGVPKDGGGKD
VAPKDSGG----------------------------------------KDGAPKEAQPKT
PQSALHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKVVKDAPATKMASIAADMASAG
PLGVFAHVLGAGPARG-----ATESQDA-----------------DDDSE----------
---------ILSPSYSAASIRPDLALSQGMLAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHI
A--------------------------------------QMPVRHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QHLTRLASMGGP--SRLGATVDILQEK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------ETV-KDHYIILDKA----------VE
KLQIRMDEFK-TLQAQVKRLEMNKVNKSTMEEE---LREKADRSALAGKANRADLET---
------------------------------------------------VALELNEMIQNM
LFKVTIHEDDWKKAVEQ----LSKDMNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--QL----
-------------Q-FQDL---------GIQE------DVQQDWGDG-------PQND--
TSFKCKSCNLSTLYPYGDPHVIDY-----DSVEVDILGVDGILYKGRMNSQRGTQASA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSSLFGAVCPP-LRPHT-SA--RS----------SA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLTD--P---------------------------QQAPGPTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPHEEPANL----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LVQ-SDLNSLKKDIEEVWNIVRKLLLEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------IH----------GGL--------------SR
I--------------------RPASANSYEY---------LQRQL--MREQQ--QQ----
-------------LHFQTF---------GVHEEGL---GLQKDWGDG-------PRNE--
TILKHKSHDLTTFYPYGDPELMDY-----DTAEVDILGVNGILYKGRMCSQIGTRM---G
EKDLAA------------------VKVSC-------HT----------------------
-------------------------------------------------VQNL----I--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRPGSLLASGYPP-LGPRTSIN--SA----------TS
---LH--SATT--------------------MMAR----SPSL--PPGPQLP-----PLI
PVSRD--P---------------------------QEAPGSAK-----------------
------------------------------------------------------------
-------------------------------RLKS-------------------------
-----------PRL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

----------------------------------------XXXXTLVVAMLKKLDLQETR
IDFQAPSPEPRRSEESARA-----ARSTPHLPAPKERRRSV--------GRAPSQALESQ
VKDLGGQVQGLSKQVKTIGSQVQGIASHVQNMSLASG-LDVAAAEWTEEQEQELGAPEAE
RARL-----W-PTP------------------------PVKG-----AEEVGVAKVELLQ
RIDE-------LEKEIKERN-----------DFMELVSQKLSLGPGGEDVTMVTWED---
LEKAIA---------------------------------DGWRTSQP-------DSEKLT
EFP-----KHRRY--TSS--TVTDV-VPSATST------RHLSTDQVLDSA--GGFGADQ
TL-RASSGTAYPSDGVPSRERIRGP-----SGTGREQHPRA---QT-ETGTLR-------
--------LHQPSLSKFTLDSDHHGSKEQFTL----------------------------
------AYPTRGEQ--------DAH----------------------PDPQSKIPVS-QG
QVSL--RPDHHG-----LGR---TGMDQPGLLHPSTHPHAVVPHSMGQ------------
----------------------------------------LGVLPPEMDDQGLVPLGMGQ
-PGLVPPLALARDQQGPELPRTDQHGMVPLSTDQHGMILPGTKQ-----PGMDKSGMKPL
GM--DQ---HGPRPPGMDQQG----------LVLPGLDQQGLVPPLTEQHGLGSSGLMPV
ST--AQRGF------------------------------------VQPSLEASGSIQPGM
DQRGLVQP--------GAGQPGIV--QPGAEQTDA------VQPGTDQHSLIQPGMDWHG
L--P--------------------------------------------------------
----GAYPPGLVQPGAYPPGLVQPGAYPPGLVQPVIDQHGLVQLGADQHSFVQPGAD-QH
GLVQPGTYLPN-------------------------------------------------
-------------------------------------------QHGAYHV----------
GLVQPGMAQLGLVQPGVDLRGLGQPGVDQHGLAQPDAGQHDFR-----------------
------------------------------------------------------------
IDQQGLGQPGVDRRGLGQPGADQPGLGQPGVNQHGLVQPG---------------VDQQG
LGQSRVGQHG-LTQP--------STVQ----RGLAQPGAVHRGLVPPRMDQRGFVPPGVD
-QLGLVPPGVNQLGLAPRGMDQHGVAQPGVDQRGFVPPGIDQRGLVPPGVDQRGFVPPGV
DQLGLVPPGVDQRGLVQPREDQLGLVQS--------GMDQGSLVQA--------------
------------------------------------------------------------
-------------------------------------------------------RT---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------DPHGLVQPGAYI--PGLVQPG----
-------------------------------------------------PDVYPD-----
-----GLVQPGAYP----------------------------------------------
--------------------------------------------------RGLVQPRM--
-----------------D-QRGLR------------------------------------
-----------------------QPDTD--------------------------------
-------------------QRGLMAPGREFHGPPTLQAYSPNFI--SPRK---YQHDVVP
---PGRQQHSQ-----------------VSPLLTSKGWALPDI--DQRGLVP-----PET
SQQGLIHPGT--DQHG--PTPVSTGSGSAYPDQQHLVSPGPGE--HGQVYPDANQHSHA-
------YSLSDDHGLMYP-GYVGPGYPSVDQYGQG-------------------------
-------------------------------------YLDPNRTFVS--------HQPGI
PAQSAS-GQDVTFFRGPDFR-------HRLSSERSEVQTERRDSLYKRAPSFPMAVETFR
LIGELIGLYVELKDRIKELDELQAGQTDLEKIQYLLAMMVQKTIPPDLEEQL-KNLQTMT
KEIRQEKAKLDRLQKFLDGEGDKE-SEEL--KT--SQLGL-QLGIL-RVTVADIEKELAE
LRDSQGQG-KAAMENSVSEAS--FYLQNQLDKLRTIIESMLTSSSTLLSMSMA--PHKAL
AHVAPGQIDPEATCPACSLDLSHQVSMLVARYERLQDMVSNLAASRPSKK--A---KLQS
QDEELLGQVQSAILQVQGDCEKLNITTSNLIEDHQQKQKDITV-----------------
-----------------LYQGLEKLEKEKATREHLELEIDMKADKSALATKVSRVQFDAT
TEQLNHMMRELVAKMTGQEQDWQKMIEKFLGEMDN-KLDRLELDPVKQLLEERWKSLRQQ
LK-ERSPHYQADEAAAMRRLMEYGELGGFGRWDFSHSNPPFFSLNLARIIPVTPVGPGLP
GHR--SIRPYMVFELEQVRQQSR-NLRLGG-AFPRGDLGQMERSVGRL--------HSMH
SKMLMD----IEKVQM-HFGGSVKASSQMIRELLQAQCLSSPCYKRVSD-MADYTYSTVP
RRCGGSHTLTYPYRR-NRLQHLPQGLCPSEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGIRAKDSES--------------------------------TGISKHKPKQPRLHL
H-RQQSLGDSS--------QLPTRPQSAQISAGNNSERKGLGAEGQDG--------KGKT
ANP---------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------MPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKLENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMVLWSG---
LHDAMFTSEI-----G----------------SSPLD---LWQSVEQL-------PEAAL
AQT-TKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGS-SAQAVSLSRAQEPAQPP
ALT--PESAPGCTT---EFAP--GPAPGTEPVPGLELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPVLGPVP-------------------APGA-Q-
-----------------PPPLGDWPALPRRWPLPQGWPRVGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFGSLWPRPLQPYQSRQGEALQ---LAAVQVKGEENDVPSLR-----
G---LR---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKA
PQSALHRLKTTAAIAAAAAAAYAA-ATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQIL-----------------GDDSEI---------
-------YEILSPSYSAASIGPDPALSQAMVATKQAMS---------------PEDK---
--------------------------------------------KRAVKYS-----MSHI
A--------------------------------------QIPVKHDSLKEEFAQLSC---
-------------------------------------NLN--------------------
---QRLSYLANMGGP--SSLGTTVDILQKK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------EMM-KDRYITLDKA----------VE
NLQIRMDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRVDLET---
------------------------------------------------VALELNEMIQGI
LFKVTIHEDSWKKAMEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFKRVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSCEY---------LQRQQ--MREQQ--WL----
-------------Q-LQDL---------GIQE------DCQQDWGDG-------PQNA--
TSLKCKSCNLLTLYPYGDPHVIDY-----DSAEVDILGVDGILYKGRVNSQRGAQPLA-V
AKELAA------------------VKAPS-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGAICPP-LCPRS-SA--CS----------AA
---SG--P-HL-----------------T--MPAR----PPSL--PPLLLLP-----PLI
PSLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVG-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSRSLLSTRS-----SLSTPHLPAPKEAPKGAPREKRRGVGRAPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-MKD---------------------------------PAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQWGPGPWSWGSETLM
GFS-----KRRGF--TSL--TSPDG-TPSGAST------RQPSIDRALDSA--GGLGPDQ
TA-SGSGGAAHPSDGVTSREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVFQFKSDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPTS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSIGQ------------
----------------------------------------LRVPPPEMDGQEWGRLVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGTDQRSMEP----------L
GM--DQ---RGFVISGMGQQGLVAAGVDQQGLILPVIDQHGLILPFTDQHGLVSPGLMPI
SA--DRQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIRS--------GRFQHALV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LVQSGAVQYGVVQPEM-DQHGLAQPGRG---------FV---QPGVDQRGLVQPDSLQHA
LVQPGAVQPGLVQPGAVQPGLVQPGAVQPGLVQPGADQRGLVQPGVDQRGLVQPDSL---
--------QHTLV-----------------------------------------------
-----------------------------------------------------QPGAVQP
GLVQPGAVQPGLVQPGVDQRGLVQPGADQSGLAQVGAVQHSLV---------------QP
GA----------DQRGLVQPGEVQRGLV-------------------QPGADQRGLVQPG
V--------------------DQRGLVQPGKVQRGLVQPG---------------AVQ--
------------------------------------------------------------
------------------------------------------YSLMQPGAVQRGLVQPGA
VQHGLVQPGVDQRGLVPPRVDQ--------------------------------------
-----------------------------------------------------------R
GSVPPRVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGSVPPRVDQ--RGLVQPGMDQR
GLVQPGAGQLGMVQPGIDQQGLVQ-----PQADPRGLVQSGAYPLGL----------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGAY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQQGQ-----------------MSPLLASQGLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPDPGK--HEQVHPDAA------
-----------HPDTMCP-GYGGPGYLIADQHGQE-------------------------
-------------------------------------GSDPSRTRAS--------DQPGI
PVQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERRDSLYKMSSSFPTAVETFR
LLGELSGLYVGLKESMKDLDEEQAGQTDVEKIQFLLAQMVKRTIPSELQEQLK-TVKTLA
KEVRQEKAKVERLQRILEGEGNQEAGKEL--KA--GELGL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQNMVNSLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVIPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHPPRGLYLTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGSRR-----RCRKE-K-------VV
CGKEKP------------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSRSLLSARS-----SLSTPHLPAPKEAPKGAPREKRRGVGRAPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-MKD---------------------------------AAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQWGPGPWSWGSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSDGVTSREQSRGP-----SGTGRQQQPRA---HD-EAGMPR-------
--------LHQSSVFQFKSDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVIDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGTDQRSVEP----------L
GM--DQ---RGFVISGMGQQGLVAAGVDQQGLILPVIDQHRLILPFTDQHGLVSPGLMPI
SA--DRQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHALV--QPGAYQPGL------VQPGADQHGLVPPGIDQSG
LAQPGRDQHGLIQPGT-GQHDLVQSGTG---------QGGLVQPGVDQPGMVQPGRFQHA
LVQPGAYQPDLVQPDADPYGLVQPGMDQSGLAQPGRDQYGLVQSGTGQGGLVQPGVD-QP
DM----------V-----------------------------------------------
-----------------------------------------------------QPGI---
-----GA----------YPPGLVPPGMDQSGLAQVGAVQHSLV---------------QP
GADQRGLGQPGADQRGLVQPGEVQRGLV-------------------QPGADQRGLIQPG
V--------------------DQRGLVQPGEVQRSLVQPG--------------------
------------------------------------------------------------
---------------------------------------AVQYSLMQPGAVQRSLVPPGA
VQRGLVQPGVDQHGLVQPGVDQRG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------LVQPGMDQ--RGLVQPGAGQP
GLVQPGTGQLRMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGL----------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGAY--------------------------------
-------------------QPGLTAPGTKLCGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQHGQ-----------------MSPLLASQRLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPDPGK--HEQVHPDAAQHGCA-
------SSLSLSPDSMCP-GYGDPGYLSADQHGQE-------------------------
-------------------------------------GLDPSRTRAS--------DQPGI
PAQKAP-GQDVTLFRSADSL---HRVSSERSEVSSEVLSERRDSLYKMSSSFPTAVETFR
LLGELSGLYVGLKESMKDLDEEQAGQTDAEKIQFLLAQMGGCCLPREEKPLSLFSAGFIL
FFPWSQLLAATRLPESLKTACHSEHSKKM--GGQRRELRVERVLVA-LVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQNMVNSLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHPPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSEWSPEAP----------------------------------RRPTRVQQ
G-VHPLWGLAL--------LWASGPWVSSFSPPL-TPNVQVSGEATR-------------
------------------------------------------------------------
---

---------MPP-ATAATTVSLRELADLSIGTPEVGAVNFNALHTLIVAMLKNLDLQNTQ
IDFQAPSPEPSRSLQSSRG-----SLSTPSLPAPKEAPKEAPREKRRSVSRTPSSALESQ
VKDLGGQVEDLSKQLKRMDGQVQGIATHVQHFSQATG-LHLAVPEWLQDQEVGARGPDSV
RTGS-----I-MK--------------------------------DTTAEELSIARVLLQ
RVDE-------LEKQIKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDA-TVSGAST------KQPSIDQALDSA--RGLGPDQ
TA-SGSSGTAHPSDGVTGREQSRAP-----PGAGRQQQPRA---RN-EADMPQ-------
--------LQPSSVFRLKLDSDRQRSKEKLTS----------------------------
------THPRRDEQ--------DARPGPAQQDLTSASG-----------QPSRVTTS-QS
QVRA--RSDRHE-----LEP---TGMDQPGFMHASTYPHGVVPLNMGQ------------
----------------------------------------LGVLPPEMDDQELVPLVMDQ
-KGTVPPSVPGRDQQGMEIPSTDRHAVVPLSPYQPGMTLPGTDQRNMEP----------L
VT--DQ---HGFAISITGQEGQVPPDMDQQGLVWPGIDQHGLVPPFTDQHGVVPPSLIPI
SA--DQQGF------------------------------------VHPSLEATGFIQPGT
EQHDLIQS--------GRFQHGLV--QPGAYPPGL------VQPGADQHGLVWPGMD---
-------QSGLVQPGT-GQRGLVQSGAG---------QGGLVQPGVDQPGMVQPGTDRTD
VLQ---IGHGLVQPLAVQPGLVQPGVDQRGLAQTGAVQLG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------LAQPG
VDQHGLIQPGAVQPGLAQSGVDQRGLARRGSVQRGLAQSG---------------SVQRG
FVQPLAVQPG-LVQP--------GVDQL--QRGLAQTGAVQPGLAQPGVDKRGLAQPGTV
-QRGLAQPGVVQRGLAQPGVDQHVQHGVVQTGAVQPD-----------------------
------------------------------------------LAQPGVDQRGLAQPG---
--A-------------------------------VQPDE----------RGLAQPGAIQH
S----------------------------------------LAQLGADQPGLAQSGAVQH
GLIQPGVVQH--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GLVQPGMDQ--SGLVQPGADQP
GLVQPGARQRGMVQPGIDQQGLVQ-----PQADPHGLVQPGAYPPGLVQP-------VQA
GVYLHDLFQPGTYP----------------------------------------------
--------------------------------------------------HGLMQPGM--
-----------------D-QYGLR------------------------------------
-----------------------QPGAY--------------------------------
-------------------HRGSIAPGTELRRSSAFQADSTGFI--SARP---YPHGVVP
---SSREQHSQ-----------------VSPLLTTQGLASPGV--GRRSLVP-----PET
YQQGLMHPGTLIHQRG--PTTVSTGLESTRPDQQHLTPPGPGE--HDQVRPDAAQRSRA-
------FSLADSRDSTHP-GYGGPRYLSADQHSQE-------------------------
-------------------------------------GLDPIRTQAS--------DQPGT
AAQMAP-DQDITLFRSPDSF----RVSSERSEVLSEVPSEHRDSLNRMSSSFPAAVETFR
LMGELSGLYLELKESMKDLDEEEIGQTEMEKIQFLLAKMVKKVIPPDLQEQV-KTVKTLA
KEVRQEKAKVERLQRILEGE----PGQEL--KA--GDLSL-QLASL-PCRH---------
-----------------------RLSCTQLDKLRTIIESMLASSSTLLSMSMA--PHQ-A
CTLDPGRIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNRLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIAM-----------------
-----------------LYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELLAKMSGQEQDWQKILDKLLTEMDT-KLDRLELDPLKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQAIPVTPAGPGLP
GHC--SICPYTVFELEQVRQHSR-NLKLGT-AFPRGDLAQMEQSVRRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQVIRELLQAQCLSSPCYKRVTD-TANHTYSTVP
RRCGGSHTLTYPYHR-SRLQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILSKDSSQ----------------------------------TSKRKSRQPRPNV
H-RQPSLSTGG--------QLPSRPQSAQMSAGNTPER----------------------
------------------------------------------------------------
---

---------MPP-TTAVTTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTQ
IDFQTPSAQPSQSPQPSRG-----SLSTPNLPAPKEAPKEAPREKRRSVTRAPPSALESQ
VKDLGGQVEDLSKQLKRMDGQVQGIATQVQHFSQATG-LHLAVPKWLEDQEVDARGLDSM
QTGS-----I-KK--------------------------------DTTAEELSIARVLLQ
RVDE-------LEKQLKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQS-------GSETLM
EFS-----KRRGF--TSL--TSSDA-TLSRAPT------KQPSIDQALDSA--RGLGPDQ
TA-SGSSGTAHPSDGVTGREQSRPP-----TGAGRQQQPRA---RD-EADMPQ-------
--------LHPSSVFRFKLDSDRQRSKEKLTS----------------------------
------THPRRDEQ--------EARPGPAQQDLTLASG-----------QPSRVPTS-QS
QVRA--RPDRHG-----LEP---TGVDQPGFMHASTYPHGAVPLNMGQ------------
----------------------------------------LGVLPPEMDDQELVPLVMDQ
-KGMVPLSVPGRDQQGLELPSTDRHAVVPLSPYQPGVTLPGTDQRSMEP----------L
AT--DQ---HGFVISVMGQQGLIPPDMDQQGLVWPGIDQHGLVPPFTDQHGVVPPGLIPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHGLV--QPGAYLPGL------VWPGMDQSGLVQPGTV---
------DQRDLAQTGA-VQPGLAQPEVD---------QRGLAQTGAVQPGLAQPGVDQRS
LAQRGSVQRGLAQPGSVQRGLVQPGVDPRGLAQTGAVQPGLAQPGVDQHV----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QRGLAQPGVDQRGLAQPG
VDQRGLAQTGAVQPGLAQPGVDQRSLVQHGSVQRGLAQPG---------------SVQRG
LVQPLAVQPG-LVQP--------GVDQ----HGLAQTGVVQRGLAQPGVDQRGLAQPGAV
-QRGLAQPGSVRRGLAQPGVDQH-------------------------------------
---------------------------------------------------GLA------
-----------------------------------QPGA----------RGSAQPGAIQH
S----------------------------------------LAQLGADQPGLAQSGAVQR
GLIQPGVVQH--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GLVQPGMDQ--SGLVQPGADQP
GLVQPGTGQLGTVQPGIDQQGLVQ-----PQADPRGLVQPGAYPPGLVQP-------VQP
GAHVHDLFQPGTYP----------------------------------------------
--------------------------------------------------RGLVQPGV--
-----------------D-QYGLR------------------------------------
-----------------------QPGAY--------------------------------
-------------------HRGSMAPATELRRSSTFQADPTGFI--SARP---YPHGVVP
---PSREQHGQ-----------------VSPLLATQGLASPGI--DRRSLVP-----PET
YQQGLMQPGTLIHQRG--PTPVSTDLESTRPDQQHLTSRGPGE--HDQVHPDAAQRSRA-
------FSLADSRDLTHP-SYGGPRYLSADQHSQE-------------------------
-------------------------------------GLLPIRTQSS--------DQPGI
AAQVAP-GQDTSLFRSPDSL---SRVSSQRSEVLSEVPSVHRDSLGRMSSSFPTAMETFR
LMGELSGLYLELKESMKDLDEEETGQTEMEKIQFLLAKMGGCLLPTEEKPPS-LGSGVQK
---NGWAKERSKLQRILEGE----SGKEL--KA--GDLSL-QLGVL-RVTVADIEKELAE
LRESQETG-KAAMENSVSEAS--LYLQDQLDKLRTIIESMLASSSTLLSMSMA--PHK-A
YTLDPGQIDPQATCPACSLDVSHQVSTLVQRYEQLQDMVNRLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNVTTSNLIEDHRQKQKDIAM-----------------
-----------------LYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKILDKLLTEMDT-KLDRLELDPLKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQAIPVTPAGPGLP
GHC--SIRPYTVFELEQVRQHSR-NLKLGT-AFPRGDLAQMEQSVRRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQVIRELLQAQCLTSPCYKRVTD-MSNHTYSTVP
RRCGGSHTLTYPYHR-SRLQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILSKDSSG----------------------------------TSKRKSRQPRPNG
H-RQPSLSTSG--------QLPSRPQSAQMSAGNTPER----------------------
------------------------------------------------------------
---

---------MPP-ATLAPSVSLRELADLAIGTPEVGAVNFTALHTLIVAMLKNLNLQEAR
INYQAQLPEQSRSFETPRA-----SSSTPQLPVSKERRRSSVSGAPP-------QALESK
VKDLSGQVQDLSRQLKTVESQVQAIVAHMQHVTVQT--SGLQAREWLEAKEMDLLA-QEK
--------------------------------------ALRESMRVWKDLSELFFQNLLQ
RIDE-------LERLTKERD-----------KFLELVSRKLSMMPSMEEATMVTWEE---
LEQAIT---------------------------------DGWRASQV-------VSESST
GLP-----KRRGQ--SSV--TSNDIIIPSGAST------KRPSLDQAMESA--TGLITDK
TF-LGTSGIGYPSEGVTGRDRSRGTPAP--GFPGREQHSRA---WD-EAGPAK-------
--------PYHPTVSQFRIESDRHRSSR--------------------------------
-EQHGLAHLRREEQ--------DAHLGPVYQGLSPATLARDWHRGAY--------IS-QG
PIFA--RPDQYG-----LGL---LATDQLASLTPSTYAQGVVPLYVGQ------------
----------------------------------------LGAVPPGMDEQELVLPDMVQ
-RDVVPPLAPSRDEQGLELSRSDQSGVVPLRTPQHGVIIPGTDQRGIRQPGVDKSGIGPL
GR--DE---RGLVPLGIDEYGFAVF--------------------PMDQQRLLSAGLIHV
AA--GPQGF------------------------------------VQPGFGTSGFIQPGT
EQPGLVQP--------GASQPGLV--QPGVGHPDL------VQPGAAQPGLVQPGAAQPG
LVQPGAAQPGLVLPGA-TQPNLVQLGVG---------QQGLVQPGAPQPDLVQPGAAQPV
LVQPGAAQPGLVQPGAAQPGLVQPGAAQPGLVQPGAAQPGLVQPGAAQPGLVLPGAA-QP
GLVQPGAAQPGL------------------------------------------------
------------------------------------------------------------
-------------------PGLVLPGAAQPGLVQPGAAQPGLV---------------QP
DAAQPGLVLPGAAQP---------------------------------------------
--------------GLVQPGAAQPGLVQPGAAQPGLVQPG---------------AGQPD
LVQPGAAQPG-LVQP--------GIYQ----PGMVQPGAAQPGMAQPGAAQPGMAQPGAA
-QPGLVQPGIYHLGSVQPGTAQPGVVQPSATQPGIMQPGAAQPGVVQPGAAQPGL-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------VQPA--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------PHGFFQPGAS--------------
------------------------------------------------MPGLFPPGLVQP
GAHPRGFMRPG-------------------------------------------------
-----------------------------------------------TDQRGLVQPAI--
-----------------D-HRWLR------------------------------------
-----------------------QSAT---------------------------------
-------------------DRGLIPLGTELPGFPTIHADPPSFL--SPSP---HQHGVVY
---PGRDQHGW-----------------GSPFLASQGLALRGT--DQEGLEP-----REA
YQQGLMPPGG--AQHG--PTPLRTRVGSASQDPQPLETPEPDE--RGDVAPAAEPPDQA-
------RSSPGSQDLGHP-GPRGPGYPGVDLFFQV-------------------------
-------------------------------------GLDPHETYDA--------SHPRM
SIQTTP-SHEAAFLGDTP----LPDSSHRASSDRSNIQTERHDSLDKLAPSFPMAVETFR
LMGELVGLYVELKENMKELDEEQAGQTDLEKLQFLLALMGVKSIPADLQEQV-KTLKALT
KEVCQEKAKLDRVNKILEGEQEQETGKDV--KA--GPLSL-QLGIL-RVTVADIEKELAE
LRESQERG-KISLEHSVSEAS--LYLQDQLDKLRTIIENMLASSSKLLSMSISVAPQKTL
TALTPGELDPEATCPACSLDLSHQVSMLVQRYEQLQDMVSNLAASRPSKK--A---KLQS
QDEELLGHIQGAILQVQGDCEKLNVTTSSLIEDHRQKQKDIDL-----------------
-----------------LYQGLEKLEKEKANREHLEMEIDVKADKSALAGKVSRVQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLVQMDN-KLDRLELDPVRQSLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGQVIPVTPVSPGLP
GHR--SIRPYMVFELEQVRQQSR-SLKLGSAAFPRGDLAKTERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSSPCYKRWTA---DYTYSTVP
RRCGGSHTLTYPYRR-SRLQHPSQGLCPTEEIQI----AMKHNEVDILGLDGHIYKGRMD
TRLPGILSRDNLGIL----------------------------------KPKPKQLRPHA
H-QPPSLSDSG--------QRLSRPQSARMLAGHNSERDTGLEP----------------
------------------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQASSPEPSRSLLSARS-----SLSTPHLPAPKEAPKGAPRERRRGVGRVPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWED---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSEGVISREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVTDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGMMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGRDQHGLVQSGT-DQLGMVQ-------------------PGADLHGLVQPGMDQ--
------DQHGLVQSGTGQGGLVQPGVDQPGMVQPGADQHGLVQIGAYQPGLVQPGMD-QH
GLIQS-------------------------------------------------------
-------------------------------------------------------G----
----PGTYPHGLVQPGADPRSLVQPGIDQHQQGLVQSGAHGLA---------------QP
GALQI--------QHGFVQPG---RSLV-------------------QPGAVQHGLVQPG
V--------------------DQRDLVPPGAVQHGLVQPG---------------VDQRG
---L--------------------------------------------------------
-----------------------------------VPPGAVQRGLVQPGVDQRGLVPPGA
VQRGLVQPG---RGLVQPGVDQRGLVQP--------G-----------------------
--------------------------------------------------------VDQR
GLVQPRVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGAGQP
GLVQPGADQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERRDSLCRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMGGCCLPREEKPLSLFSAGFIL
FFPWSQLLAVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIEGMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVISRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGS-----------------------
------------------------------------------------------------
---

---------MPP-ATPATKVSLRELADLAIGTPEVGAVNFTALHTLIVAMLKNLNLQETV
IDFHTLSPKGGRSVEALQAPSRSTLSSAPQLHHSKDQHKTASRSSSHA-LGSQVEELGSQ
VKELGSQVEGLTKQLKTVDSQMQVIAAQVQQITSTSTELGFEAPTVLEVK-NMSMP-DTE
EA---------QI----RSTEVQEDVRKPMNLLHDVVEDVKILKEAYQKAQELKPQEVFQ
RIEK-------LEKLIKERD-----------DFLEYMGQKLTLVPSGEEVTMVTWEE---
LEEAIA---------------------------------NGWKASQV-------GSETAL
GLS-----KRKVQ--SSL--TSSDL-IQSGVST------KYTSTDHIPDSA--GGPRQPL
---PGSSATGHLYEAVTI--K-QRGKGS--FAPGREQHTRA---HA-EANAS--------
-------RFYQPSIPQFRTESDHHRSREQFTS----------------------------
------GYPRRD-----------IHTGPAQQDLPLAR---------------DQPIG-QG
QVYV--RPDHHE-----LGL---PGIDQLGLPYASTTLPGVVPISVSQ------------
----------------------------------------LGMLPPQMDCQGLEPLGMDQ
-RGVVPPLVPGRDQQRSGLPGTDQLGVVPLSPYQYGMIIPGTDQCSMKQPGMPESGMRPL
GI--DQ---HGFVTLGVNQGGLVPPGGVQQGLEPSGIDQHGLSPVPIDRHGLVSPGLIQV
NA--DQQGF------------------------------------VQPSLETSGFIQPGT
EQHDLIWP--------DRNQSTLG--QPGTYRPGL------AQPGAEQHGLVQPGEH---
-----------------------------------------------PPDLVQPGKDQDS
LIQPGLDQRRLIQPGTVQHGLTQPGVAQLDVAQHGADQHGLVHPEMGRHDLMQPGTF-PS
GWVQPGAYPP--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------AWAQAG---------------ADSHR
PVQPGIGQHG-FVQP--------RMDQ----SDVVQLGADQQ------------------
-----------------------GSVQPGADQQGSVQPGADQQGSVQPGADQQGS-----
------------------------------------------------------------
-------------------------------------------------VLLVPPGMDQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RGLVQPGM--
-----------------D-QHGWR------------------------------------
-----------------------QPSAD--------------------------------
-------------------HQSLIVPGTELCRFPPFQADLRSLRSPHPYP---YPRGMVP
---PGQEQHGR-----------------LSPFLASQASSSPRT--DKESI----------
-----------------------------RPDQQYLVSPGPDQ--QAQIYPGAVQPGQE-
------HPVWDQQGPGYS-GYGGPGSLGVDPRGRV-------------------------
-------------------------------------ALDPNRIPDF--------PAQTE
S------DQDATSDRSQDSLSFLHQVSSERSEPRSGTQSEQRNSLEKLAPNFPMALETFR
LMGELIGLYVELKENLKDLDEEKAGQTDREKIQYLFTLMVKKILLPDLQEQM-KTLKALP
KEVHQEKAKVEKVQRLLEGDGEQVAGEEL--KA--GQLAL-QLGLL-RITVTDIEKELAD
LRDSQEQG-KAAMENSVAEAS--LYLQDQLDKLRTIMESMLASSSTLLSLSIT--PHKPL
TILAPSQIHPEATCPACSLDLSHQVSTLVQRYEQLQEMVSNLAASRPSRK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHWQKQKDIDV-----------------
-----------------LYQRLEKLEKEKANRKHLQMEIEVKADKSALASKVSRVQLDAT
TEQLNHMMQELMAKMSGQEQDWQKLLDKLLAEMDM-KLDRLELDPVKQALEDRWKSLREQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGRIIPVTPVGHALP
GHR--SIRPYTVFELEQVRQQSR-NLKLGSTFLPRGDQSAMEQSVGRL--------RTMH
SKMLWD----IEKVQI-HFGGSVKTSSQMIRQLLQAHCLSSPCYKRGPN-SADHTCSTMA
RRCGGSHTVTYPYRR-NRLQHPSQALYAPEEIRI----AMKHAEVDLLGLDGHIYKGRMD
TRLPGILTKDISSQYRQGR----PVSSVG-RLA--------------------Q--SDMA
HPPSPNLQGSLPGLEVNMDMPP-GEGLKEPTRGPRST----TAQGT-----EV-------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTIKALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNRKMIALQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFASEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEDSSSAQAVSLSSAQEPAQPP
ALT--PESTPGRAT---AFAP--GPAPGTEPVPGPELGLEL---EP-VPALGP-------
--------VPGPTVT---------------------------------------------
-----------------PGS--LPAPWPMLGPAP-------------------APGA-Q-
-----------------PPPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRGGKDGAPKDRGGKDGAPKDRAHKDEVPKDRGGKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GNDSEI---------
------YYEILSPSYSAASISPDTALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLANMGGS--ASLGTTVDMLQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------QAM-KDRYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LKEKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQH--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSV-I
AKELHWAPR------------APLPGAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPA--------------------------
---RD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPQEEPTNP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSITFTELVNVAI--PQCGVVNFKALHLLLQGILEHIQIAELK
KVLSGEEDFLQS-SPAVF--------------IPREGDA----Q-----------PVINP
MKRLSNIFDQVVDRIEKIESKL----AEMQDIPT--------TSQLVEE---------SY
GDKRPAEEMWNNIKIQKRIEGNEKATEKFTRTLQDLLNDLHVLKGSVETVQ-----KDVD
TIKFIFEKV-NPQKLELLGDDLKTQSRKLGALQREVVTLQNKVRAVPQPEEMVLWSG---
LHEAMFSPEQ---------------------QKLEVEPSGVWQSMVSL-------PESPL
EQP-----EDAGYIHI--PIHSATPVPTMVQLGTTGALREEE-LTRAVELADSQRPELAP
AFVSQTQ----RLE---RAQA------S------------------------V-------
--------SQ--------------------------------------------------
---------------------------TQRLER---AQASVSQTQN-LRQT----AP-FP
FPVPGFVP---GPDFMPVYGPRPGMATPSAWALPRGLARGNF------------------
----------------------------------WPI-WGIGPYQPGQGPFQPMG----P
MPRVPF----PAMGSDIPWTQPLPQG-----T-QW---YPNIEERGPEYEEQYPE-----
G---YQ---EEMPMDEAPQEEMAVYGALEEEIPTEGAPQDGIPKGRAR-ERISKEKVPKY
RTPKERVSY-----HKVSKDVSPEDTGTKDEAPEVKVLKKVVYKDRPQKDKAP-EPHRKG
PSSAIKKLRSAIATAAAAAAAYAA-QANSAAQLAKDAVKAIQDVPANQLASKAALIASSG
PLGAFADFLGAGFGHG-----ATSNIPF-----------------DEGEL----------
EEF----PEEF-AAPF-NPFTTKPVLSQAMISAMQATS---------------PEEK---
--------------------------------------------KKAVQYS-----MSHI
A--------------------------------------QMPSRHNSLKEEFTNLST---
-------------------------------------TLN--------------------
---QRLNYLANMGSS--GVLGSTVNVLEEK-I-----------INLQKARLQEEELERVW
GHQI------------------------------DTM-KSHYMVLDRA----------VE
RLQIRMDDLK-ILKAEIERLDLVKADKNVMDLE---LNEKANRDALASKANRVDLET---
------------------------------------------------VAMELNEMTHSM
LLKITNSESDWKKALKH----LRKDLNTKLVQ-SDLNSLKKDIEEVWKVVRKLLLEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TH-----------GL--------------SR
I--------------------RPASANSYEY---------LQRQL--IREQQ--QH----
-------------LHFQNF---------GVHEEGQ---GFQKDWGDG-------PRNE--
NTLKHKSHDLSTLYPYGDPELMNY-----DTAEVDILGVDGVLYKGRMSSQFGTRT---G
EKDIAA------------------VKVSY-------YT----------------------
-------------------------------------------------IPNL----T--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRPGSLLAPGYPP-LGPRSSVT--SA----------TT
---LH--SATN-----------------T--TTAR----PPSL--PPVPQLP-----PLI
PVSRD--T---------------------------QEAPGSAK-----------------
------------------------------------------------------------
-------------------------------RLKS-------------------------
-----------PRL----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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------------MENSVSEAS--LYLQEQLDKLRTIIENMMASSSTLLSMSM--APHKAL
TTLAPGQIDPEATCPACSLDVSHQVSMLVQRYEHLQDMVNNLAASRPSKK--A---KLQS
QDEELLGHVQSAILHVQGDCEKLNITTSNLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLKKEKANREHLEMEIDMKADKSALAAKVSRVQFDAT
TEQLNHMLQELVAKMSGQEQDWQKMLDKLLVEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPLTGQIMPLTPVGPGLP
GHR--SMRPYTVFELEQVRQQSR-NLRLGS-AFPRGDLAQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLQAQCLSSPCYKRVPD---DYTYSTVP
RRCGGSHTLTYPYRR-SRLQHLSQGLCPAEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILTKDT----------------------------------AGISKHKSKQSRPHR
---QRSLSDSS--------QLPSRPQSAQMLAA-----STRHRKDRPISSE-GRLSQPNI
AHPPSPMEMA--DLQGS-----PLGLEMH------MDVPPG--EGIEEPTRGPRSATVHR
PER

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQPSSPEPSRSLQSVRS-----SFSIPHLPAPKEVPKGAPREKRRGVGQAPSSALESQ
VKDLGGQVEDLSKQLKRVDGQVQGIATYVQHFSQASG-LDLAALEWPEEQEVGVRALDRV
RTGS-----I-MKD---------------------------------AAEEPSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVRRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQWGPGPWSWGSETLM
GFS-----KHGGF--TSL--TSPEG-TLSGAST------KQPSIEQALDSA--SGLGLDR
TA-SGSGGAAHPSDGVSSREQSKVP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSTFQFKSDSDRHRSREKLAS----------------------------
------TQPRRDVR--------DARPGPVQQDLPSARD-----------QPSRVPAS-QS
QVHL--RPDRRG-----LEP---TGMNQPGLVPASTYPYGVVPLSMGQ------------
----------------------------------------LGVPPPEMDDRELIPFVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQCSMEP----------L
GM--DQ---RGFVVSGMGQQGLVPPGMDQQGLTLPVVDQHGLVLPFTDQHGLVSP-----
----DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQRALV--QRGAYQPAL------VQPGADQRGLVRPGMDQSG
LAQPGRDQHGLIQPGT-GQGVLVQ-------------------PGVDQPGMVQPGR----
------FQRALV------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------QPGAYQP
GLVQPGADQRGLIRPGMDQSGLAQPGRDQHSLVQP-------------------------
GTGQHDLVQSGTGQGGLVQPGVDQPGMV-------------------QPGADQIDVV---
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------QPGAVQRGLVQPGA
DQRGLVQPGVDQ------------------------------------------------
-----------------------------------------------------------H
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGADQP
GLVQPGAGQLGMVQPGIGQQGMVQ-----PQADPHGL--------------------VQP
GAYPLGLVQPGAVQ----------------------------------------------
--------------------------------------------------RGLVQPGA--
-----------------V-QRGLV------------------------------------
-----------------------QPGVD--------------------------------
-------------------QPGLIAPGTKLRGSSTFQADSTGFI--SVRP---YQHGMVP
---PGREQYGQ-----------------VSPLLASQGLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPGPGE--HDQVYPDAAQHGHT-
------FSLFDSRDSVYP-GYRGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DRRGI
PAQKAS-GQDVTLFRSPDSV---DRVSSEGSKVSSEVLSERRDSLCRMSSSFPTAVETFG
LMGELSSLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQMGGCRLPIEEKPLSLFSVGFIL
FFPWPQLLA-----------HVPQPSESK--KM--GGQRR-ELRVE-RVLVALSEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HSLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLAEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-EHPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HLGGSTKASSQIIRELLHAQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILRKDSEWSPEAP----------------------------------RHLTWVPQ
G-VHPLWGLAL--------LWATRPWVSSFSIPLTPNVQVSRKATR--------------
------------------------------------------------------------
---

---------MPP-ATAVTTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKTLDLQNTQ
IDFQAPSPEPSRSLQSSRG-----SLSTPNLPEPKEAPKEALREKLRSVSRAPPLALESQ
VKDLGGQVEDLSKQLKRIDGQVQGIATHVQHFSQATG-LHLAVPEWLEEQEVGVRGPDSV
RT----------------------------------------------AEELSIARVLLQ
RVDE-------LEKQLKDRE-----------QFLELVSRKLSLDPGVEEVTMVTWEE---
LEQAIT---------------------------------DGRRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDA-SLSGVST------EQPSTDQALDSA--RGLGPDQ
TA-SRSSGTAHPSDGVTGREQSRAP-----AGAGRLQQPRA---RD-EADMPQ-------
--------LHPSSTFQFKLDSDRQRSREKLTS----------------------------
------THPRRDEQ--------DARPGPAQQDLTLASG-----------QPSRVPTS-QS
QVRA--RPDRHG-----LEP---TGTDQPGFMHAGTYPHL--LLNMGQ------------
----------------------------------------LGVPPPEMDDQELIPLVMDQ
-KGMVPPSVPGRDQQGLELPSTDRHAMVPLSPYQPGMTLPGTDQRSMEP----------L
VM--DQ---HGFIISVTGQQGLVPPGMDQQGLVWPGIDQHGLVPPFTDQHG---------
------------------------------------------------------------
----------------------LV--QPGAYPPGL------VQPGAGQRGLVWPGMD---
-------QSGLVQPGT-GQHGLVQSGAG---------QGGLVQPGVDQPGMVQPGTDRID
VVQFGAYPPDLVHPG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MDQHGLVQPGTFPSGR--------------------------------------------
------------IQP---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------DDGVDEH
G----------------------------------------LAQLGADQPGL--------
--GQPGVDEC--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GLAQPGADQ--PGLVQPGADQP
GLVQPGAGQLGMVQPGIDQQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GLMHPGTLINQRG--PTPVTTGLESTLPNQQHLTSPGPGE--HDQVHPVAAQRSRA-
------FSLADSRDSTHP-GSGGPRFLSADQHSQE-------------------------
-------------------------------------GLDPSRTQAS--------DEPGI
PAQMAP-GQDITLFRSPDSL---GRVSSERSEVLSEVPSEHRDSLRRMSSSFPTAVETFR
LMGELSGLYLELKESMKDLDEEETGQTEMEKIQILLAKTVKKIIPPDLQEQL-NTVKTLA
KEVWQEKAEVERLQRILEGE----PGKEL--KA--GDLSL-QLGDL-RVTVADIEKELAE
LRESQETG-KATMENSVSEAS--LYLQDQLDKLRTIIESMLASSSTLLSMSMA--PHQ-A
YTLAPGQIDPEATCPACSLDVSHQVSTLVQRYEQLQDMVNRLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNVTTSNLIEDHRQKQKDIAM-----------------
-----------------LYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSAQEQDWQKILEKLLTEMDT-KLDRLELDPLKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQAIPVTPAGPGLP
GHC--SIRPYTVFELEQVRQHSR-NLKLGT-AFPRGDLAQMEQSVRRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQVIRELLQAQCLSSPCYKRVTD-TANYSYSTVP
RSCGGSHTLTYPYHH-SRLQHLPRGLYPTEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILSKDSSG----------------------------------TSKRKSRQPRPNV
H-RQPSLSASG--------QLPSRPQSAQMSAGNTPERQ---------------------
------------------------------------------------------------
---

------------------------------------------------------------
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------------MENSVSEAS--LYLQDQLDKLRTIIENMLSSSSTLLSMSMT--PHKFT
GTTVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSSLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLEKEKADREHLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPVKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETSVTGQVLSMTPMVPSMP
GHR--SIRPYTVFELEQVRQQSRSNLKLGG-SLSRGDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHAQCLSHPCYKRGLE-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILAKDASGMPKSKSRQLQQLQQLQ-------QL------QQLQQLQQGQHGRPHN
H-RQPSL---G--------LPPFRPLSAQMLTDSNAV-SSGQKKDRPVSSE-GRLSQSIM
AHSLGPTEMA--GLQGS-----PSGLKVH------MEVSPR--EEMEEPTRGPRSTAAH-
---

---------------MSFSLTFTELADIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVM--------------MPREGEA----Q-----------PILNP
MKRLSNVFDHVVSRLDKLENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPVQDLWHLIKLRKMVEGHDEVMAKSMQTLQDLLTDLHALQVTITALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNWKMVALQREVASLQNKFKTIPKTEDMVLWSG---
LPDAMFTSS-----------------------------------IEQL-------PEAAL
AQT-TEYLEATPAIQVSEPVQNPQLLQTVWHYEVPELLPEGS-SAQAVSLSRAQEPAQPP
ALT--PESAPGCTT---EFAP--GPAPGTEPVPGLEVGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPVLGPVP-------------------APGA-Q-
-----------------PPPPGDWPALPRRWPLPQGWPRVGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFGSVWPRPLQPYQSRQGEALQ---LAAVQVKGEENDVPSLR-----
G---LR---ERARKDG---------------------------------DGVPKDRGGKD
VDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEAQPKA
PQSALHRLKTTAAIAAAAAAAYAA-ATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAG
PLGVFADVLGAGPSRE-----ATESQIL-----------------GDDSEI---------
-------YKILSPSYSAASIGPDPALSQAMVAAKQAMS---------------PEDK---
--------------------------------------------KRAVKYS-----MSHI
A--------------------------------------QIPVKHDSLKEEFAQLSC---
-------------------------------------NLN--------------------
---QHLSYLANMGGP--SSLGTTVDIVQKK-I-----------GSLQKSRLKEEELERIW
GNQI------------------------------EMM-KDRYITLDKA----------VE
NLQIRMDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRVDLET---
------------------------------------------------VALELNEMIQGM
LFKVTIHEDSWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFKRVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-LQDL---------GIQE------DCQQDWGDG-------PQNA--
TSLKCKSCNLLTLYPYGDPHVIHY-----DSAEVDILGVDGILYKGRVNSQRGAQPLA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALFGTICRP-LCPCS-SA--CS----------AV
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PSLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVG-----------------------------------------
----------------WKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

------------------------------------------------------------
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------------MENSVSEAS--LYLQEQLDKLRTIIESMLASSSTLLSMSIT--PEKPH
IPMMPGHMNLEATCPACSLDVSHQVSLLVQRYEQLQDMVNSLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKEIDE-----------------
-----------------LYQGIQKLEREKANRESLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGKEQDWQRMLDKLLAEMDN-KLDRLELDPVKQSLEDRWKSLRQQ
LR-ERPPLYQSDEAAIMRRQLL-------AHFHCLSCDRPLETPVTGQTIPVTPVGPSLP
RHR--SLRPYTVYELEQIRQQSR-NLKLGA-PFARGD--QMDRSVGRL--------RTMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELMQARCLNRPCYKRVPD--ADYTYSTIP
RRCGGSHTITSPYRR-SRLQHL-QGLIPHEDIQI----AMKHDEVDILGLDGHIYKGRMD
MKLPDILTKDNIS---------------------------------GMTKHRSRLSRAHI
S-RQPSLGSNG--------QLFSRPHSAQMSPDNSGRKQ------SPLSPS--CLAESSL
KQQEEASEGR--SSQG--------GFRETESLPASLGKPPGDEEEDEEPTRGPRSSARTL
---

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LVH-SDLNSLKRDIEEVWKVVRKLLIEGLRF
DPDSAA-GFKKKLFERVKCI-----SCERPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
N----------------------------TR-----------GL--------------SH
M--------------------RPASANSFEY---------LQRQL--MREQQ-QQQ----
-------------LHFRNF---------GVQEEGL---GSQKDWGDG-------PRNE--
TTFKHKSHDLSTLYPYGDPVLMDY-----DTAEVDILGVDGVLYKGRMNSQTGTRI---G
EKDLAA------------------VKVSY-------AP----------------------
-------------------------------------------------VQNM----G--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRTGSLLAPGYPP-LGPRSNII--SS----------AT
---SP---HSA-----------------A--TVAQ----PPSL--PPVPQLP-----PLM
PLSKD--P---------------------------QEAPGSAR-----------------
------------------------------------------------------------
-------------------------------HLKL-------------------------
------------RLE---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHSILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGEA----Q-----------PILNP
MKRPSSVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLQKTVEGHDEVMAKSMQTLQDLLTDLHALQVTITAIR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNRKMIALQREVASLQSKFQTIPKTEDMVLWSG---
LHEAMFTSEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQISEPVQNPQLLHTVWHYEVPELLPEDSSSAQAVSLSSAQEPAQPP
ALM--AESAPGHAT---AFAP--GPAPGTEPVPGLELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PES--LPAPWPVLGPAP-------------------VPGA-Q-
-----------------PPPPGGWPALPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASVWPQPLQPYQSRQGEDLQ---LTAVQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TGKDGVPKDRGGKD
VDPKDR----------GGKDGAPKDRGGKDGAPKDRGGKDGAPKDRAGKDGDPKEAQLKA
PRSALHRLKTSAAIAAAAAAAYAA-AASSAAQTAKVAATLVKDAPATRMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GDDSEI---------
------YYEILSPSYSAANIGPDAALSQAMVAAKQATS---------------PEDK---
--------------------------------------------KRAVSCS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLNYLANMGGS--ASLGTTVDILQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------EAM-KDRYVTLDKA----------VE
KLQIRVDEFK-TLQAQIKRLEMNKVNKSTLEEE---LREKADRSALAGKASRADLET---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDNWKKAVEE----LSKDVNMKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AQ-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQQ--MREQQ--RL----
-------------Q-RQDL---------SIQK------DYQQDWGDG-------PQNA--
ASLKCKSCKLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSA-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPTQ----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------LVH-SDLNSLKKDIEEVWKIVRKLLIEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TN-----------GL--------------SR
L--------------------RPASANSFEY---------LQRQL--MREQQ--HR----
-------------VHFQNF---------GAHEEGL---GSQKDWGDG-------PRND--
TTFKHKSHDLSTIYPYGDPEIMDY-----DTAEVDILGVNGILYKGRMNNQFGTRT---G
EKDLAA------------------VKVSC-------PS----------------------
-------------------------------------------------VQNP----N--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRPGSLLTPGCPP-LGPRTSF---SS----------A-
----------------------------T--TAAR----PPSL--PPVPQLP-----PLM
PPSRD--L---------------------------QEAPGSTR-----------------
------------------------------------------------------------
-------------------------------HTKS-------------------------
-----------LRLE---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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------------MENSVSEAS--LYLQEQLDKLRTIIESMLSSSSTLLSMSIT--PHKSA
SAMVPGQMDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIDV-----------------
-----------------LYQGIERLEKEKADRDRLELEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPVKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETSVTGQVLSMTPIVPSMP
GHR--SIRPYTVFELEQVRQQSR-NLKLGG-SFSRGDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHAQCLSHPCYKRGLE-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----TMKHDEVDILGLDGHIYKGRMD
TRLPGILGKDAPGMAKPKSKQLQQLQQLQ----QLQQL------QQLQQMQQAQHARPHT
H-RQPSLGNNS--------LPPSRPQSAQMMADSTSV-SSGQKKDRPISSE-GRLSQLNV
APPSGSAEMA--GLPGG-----PSGLNVH------MDVSPR--EGMEEPTRGPRSTTAH-
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQASSPKPSRSLQSVRS-----SLGTPHLPAPKEVPKGAPREKRRGVGREPSSALESQ
VKDLGGQVEDLSKQLKRMDGQVQGIATHVQHFSQASG-LDLAVREWPEEQEVGVRALDRV
RTGS-----I-TKD---------------------------------ATEELSFARVLLQ
RVDE-------LEKLFKDRE-----------KFVQLVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRGSQA-------GSETLM
GFS-----KHRGF--TSL--TSPEG-TLSGAST------KQPSIDQALDSA--SGLGPDQ
TA-SGSGGAAHPSDGVTSREQSKVP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSIFQFKSDSDRHRSREKLTS----------------------------
------TYPRRDER--------DACPGPVQQDLTLARD-----------QPSRVPAS-QS
QVHL--RPDRRG-----LEP---TGMNQPGLVPASTFPHGVVPLSMGQ------------
----------------------------------------LGVPPPEMDDRELVPFAMDE
-QRMLPPSVPGRDQQGLELPGMDQHGLVSVSAYQHGMTLPGTDQRSMEP----------L
GM--DQ---RGFVISGMGRQGLVPPSMDQQGLTLPVIDQHGLVLPFTDQHGLVSPGLMPI
SA--DQKGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHALV--QPGADQPGL------VQPGADQRGLVQPGADQRG
LVQPGADQRGLVQPGA-DQRGLVQ-------------------RGEDQHGLVQPGT----
------VQRG--------------------------------------------------
-------------------------------LV---------------------------
-----------------------------------------------------QRGADQR
GLVQRGADQRGLVQPGADQRGLVQPGADQR------------------------------
-----GLVQRGADQRGLVQRGADQRGLV-------------------QPGADQRGLV---
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------QPGADQRGLVQPGE
VQRGLVQRGEDQ------------------------------------------------
-----------------------------------------------------------H
GLVQPGAV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQRGTDQ--RGLVQPGADQP
GLVQPGAGQLGMVQPGIDQQGLVQ-----PQADPRGL--------------------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------RGSVQPGM--
-----------------D-RYGLR------------------------------------
-----------------------QPGAY--------------------------------
-------------------QPGLIAPGTKLRGSSTFQADSTGFI--PVRP---YQHGMVP
---PGREQHGQ-----------------VSPLLASQGLASPGI--DQRSLIP-----PET
YQQGLMHPGT--DQHG--PIPPSTGLGSTHPDQQRLASPGPGE--HDQVYPDAAQRGCA-
------FSLSDSRDSMYP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPHRTQAL--------DRRGI
PAQKAS-GQDVTLFRSPDSV---DRVPSEGSEVS----SQRRDSLYKMSTSFPTAVETFR
LMGELSSLYVGLKESMKDLDEEEAGQTDLEKIQFLLAQMVKRTIPPELQEQ-LKTVKTLA
KEVWQEKAKVERLQRILEWEGNQEAGKEL--KA--GELRL-QLAVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PRK-A
HTLAPGQIDPEATCPACSLDVSHQVSMLVQRYEQLQDMVNSLAISRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHQQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SLRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSAKASSQIIRELLHTQCLGSPCYKRVTD-MADYTYSTVP
RHCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKCGEVDILGLDGHIYKGRMD
TRLPGILRKDSSGTSTCK----------------------------------SQQPRPHE
H-RLPSLGGNG--------QLPSRPQITQMSAGNTSERQ---------------------
------------------------------------------------------------
---

---------------MSFSLTFKELVNIAI--PQCGVVNFKALHLLLQGMLEHIHMDGLK
KVLSGDEDFLQT-SPAMT--------------VPREGDA----Q-----------PILTP
MKRLSNVFDHVVSRVDRIENQL----AMLQELPT--------TSQLLEA---------SQ
GTGRPAQDLWNLIKVRKMVEGVEEATAKSMQTLQDLLTDLHILQVGAETLR-----KDVD
RLKDLYEKI-HPERIDIFTDDLRAQNRKVNLLQRDMISLQNKFRTIPKIEEMVLWSG---
LHEAMFSSL---------------------------EPSSLWKTTQQL-------PDAAL
AQS-TEYGEAGRPTQVSEPVQPPQLLQTAWQYEAQQLPPEEE-STLEVSVGDAQKPGQRP
ALR--PSAPGPTPE---SSAPGHTPESAPGPTPGLAPGLPS---EP-MAWLGP-------
--------VVGPGGM---------------------------------------------
-----------------PGF--MTAPWAAQGAQ---------------------------
-----------------LLPAGVWPMPPGVWPVPEGGPRPGT------------------
----------------------------------EAS-LGLPFQHPAQTQ-------GPT
ASRAPP----PATELGSAWPPPLQPFQPYGADAQQ---LPAVEERREETDASFRR-----
M---SQ--------DGI-----------------------------------PKEEAPKH
RKA------------------------------KDRAHKDAARKDRAPKDGAPREAQPQD
ALPSIQRMKTTSAFAAAAAAAYAA-SARSAAQAATAAAKVVKDAPATKMASVATSMATSG
PFGLSSDVLGAGPSRG-----LEEVQAD--------------------------------
-------YDNFSPPYY-PVITPEATVSQAMVT--EAAS---------------PEEK---
--------------------------------------------KKAVKYS-----MNYI
A--------------------------------------QIPIQHDSLKEEIAQLSS---
-------------------------------------SLN--------------------
---QRLTFLGRGPAG----LRSSLWPSRST-S-----------CPPFGSPKQNLHSTIIW
GHQI------------------------------EMI-KDHYLVLDRA----------VE
RLESRLDEFK-LLQGQIRALEMNMATKSMIEQE---LKEKADRGAVASKANRADLET---
------------------------------------------------VATELNEMVQGM
LLKVSAHEHNWKKTMER----LKKDVSTKLVH-SDLDSLKKDLEEVWKILQKLLVEVFRF
DPDGAA-GFRKKLFERVKCI-----SCDRSVEMMTS------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
Q----------------------------AH-----------LL--------------SR
L--------------------RPVSANSYEY---------LQRQE--MREQQ--RL----
-------------Q-FRDL---------RIQEG---LDSRQQNWGDG-------PRDD--
ANPKHKSHNLSTLYPYGDPDMMDY-----DSAEVDILGVDGILYKGRMSQV-AAQSSGGV
DTELAA------------------VKVPC-------PP----------------------
-------------------------------------------------SRSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VSSGALFGSIYSP-MCTRT-ST--YS----------DA
---LG--S-HM-----------------T--MPAR----PPSL--PPLPLLP-----PLV
PHPRD--P---------------------------QQPPGPAR-----------------
------------------------------------------------------------
-------------------------------PLRP-------------------------
-----------LRLESRAS-----------------------------------------
----------------KHLPEEPVNP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

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------------MENSVVEAS--LFLQDQLDKLRTIIENMLASSSTLLSLSMT--PHKSL
AGMAPSEIHPEATCPACSLDLSHQVSTLVQRYEHLQEMVNNLAASRPSKK--T---KLQS
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIDV-----------------
-----------------LYQGLEKLEKEKANREHLQMEINVKADKSTLASKVSRVQFDAT
TEQLNHMMQELMAKMRGQEQDWQKLLDKLLAEMDM-KLDRLELDPVKQELEDRWKSLREQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGQIIPVTPVGQALP
GHR--SIRPYTVFELGQVRQQSR-NLKLGG-TFPRGDQSSVERSVGRL--------RTMH
SKMLLD----IEKVQI-HFGGSVKASSQMIRELLQAHCLSSPCYKRVPD-SSDYTYSTMS
RRCGGSHTLTYPYRR-NRLQHLPQGLYAPEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILTKDPSG----------------------------------TTKHKPKQSRPHG
H-RQQPLSNTS--------QLPSRPQSAQASAANSSV-SSKQRKDRPVSSE-GRLAQSDM
THPPSPDL------QGG-----PTELGMN------TAMPPE--EGLEEPTRGPRPSTAQ-
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWED---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSEGVISREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVTDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGMMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGRDQHGLVQSGT-GQGGLVQPGVD---------QLGMVQPGADLHGLVQPGMDQSG
LAQPGRDQHGLVQSGTGQGGLVQPGVDQPGMVQPGADQHGLVQIGP--------GMD-QH
GLIQ-SVDQR--------------------------------------------------
------------------------------------------------------------
GLVQPGEVQRGLVQPGVDQHGLVQPGEVQRGLVQPGAVQYTLM---------------QP
GAV--------------------QCSLV-------------------QPGAVQHGLVQPG
V--------------------DQRDLVPPGAVQRGLVQPG---------------VDQRG
L-----------------------------------------------------------
-----------------------------------VPPGAVQRGLVQPGVDQRGLVPPGA
VQRGLVQPG---RGLVQPGVDQRGLVQP--------G-----------------------
--------------------------------------------------------VDQR
GLVQPRVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGAGQP
GLVQPGADQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASLGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERRDSLCRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMVKRTVPSELQEQLK-TIKTLA
KEVRQEKVKVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPVGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSAGNISGRFPLGGASCQAS-L-------LA
LPAPFPAM----------------------------------------------------
---

------------------------------------------------------------
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------------MENSVSEAS--LYLQDQLDKLRTIIESMLSSSSTLLSMSIT--PHKST
STLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNVTTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLDKEKADREHLEMEIDVKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLVDKLLAEMDS-KLDRLELDPVKQMLEDRWKSLRQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETAVTGQVISMTPIVPSMP
GHR--SVRPYTVFELEQVRQQSR-NLKLGG-SFARGDLSQMERSVGRL--------RSMH
SKMLMD----IEKVQI-HFGGSVKASSQMIRELLHAQCLSHPCYKRGVD-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKD--GVAKHKSKQLQQLQQLQ-QF---QQL------QQLQQLQQAQHARPHM
HSRQPSLGHSG--------LPPSRPQSAQTA----DS-NSGRKKDRPLSSE-GRLTQPNV
AHTSTPTEMA--SLRGS-----PDGLNMH------MGGHPG--QGMEEPTRGPRSTTAH-
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSRLLLSARS-----SLSTPHLPAPKEAPKGAPREKRRGVGRVPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETVM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSEGVISREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGMMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGRDQHGLIS--------VVW-------------------PGMDQSGLAQPGR----
------DQHGLVQSGTGQGGLVQPGVDQPGMVQPGADQHGLVQIGAYQPGLVQPGMD-QH
GLIQSGAFPSGWI-----------------------------------------------
-----------------------------------------------------QPDVYLP
GLVQPGTYPHGLVQPGADPRSLVQPGIDQRGLVQLGADQYGFV---------------QP
GIDQLGLVQRGADQQGLVQSGAVQYGVV-------------------QPGMDQHGLAQPG
A--------------------LQSSLGQPGAVQHGFVQPG---------------VDQRG
LVQPDS------------------------------------------------------
-------------------------------LQRXXXXXXXXXGLVQPGVDQRGLVQPGA
DQSGLAQVGAVQHSLVQPGADQRGLGQP--------G-----------------------
--------------------------------------------------------TDER
GLGQPGTD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------ERGLVQP-----------------
-------DQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHDQE-------------------------
-------------------------------------GLDPNRTRAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSEKSEVSSEVLSERRDSLCRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMGGCCLPREEKPLSLFSAGFIL
FFPWSQLLAVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVISRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVIPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGG-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGS-----------------------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQCGVLNFKALHLLLHGILEHIHMAELK
KVLSGDEDFLQT-SQVVI--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRLDKMENQL----ALLQDLPS--------TAQLLEA---------SQ
GTARPIQDLWHLIKLRKTVEGHDEVMAKSMQTLQDLLTDLHALQVTVKALR-----KEVD
MLKNMLDKV-HPERMDIFAEDFKIQNRKMISLQREVASLQNKFQTIPKTEDMVLWSG---
LHEAMFASEI-----G----------------SSQLD---LWQSMDQL-------PEAAL
AQT-TEYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLLEDSSSAQAVSLSSAQEPAQPP
ALT--PESAPGRAT---AFAP--GPAPGTEPVPGPELGLEL---EP-VPALGP-------
--------VPGPSVT---------------------------------------------
-----------------PGS--LPAPWPRLGPAP-------------------APGA-Q-
-----------------PPPPGGWPAFPRRWPLPQGWPRMGS------------------
----------------------------------WPL-WDLGVLRPTQ----------PQ
PSRAPP----PATEFASAWPQPLQPYQSRQGEDLQ---LTAIQEKGEENDVPSLR-----
G---LQ---ERARKDGAPKDR-------------------------TRKDGVPKDRGGKD
VDPKDRGGKDGAPKDRGGKDGAPKDRAHKDEVPKDRGGKDGAPKDRVGKEGDPKEAQLKA
PRSAFHRLKTTAAIAAAAAAAYAA-AASSAAQTAKVAAKLVKDSPATKMATIATDTAAAG
PLGVFADVLGAGPSRG-----ATESQAL-----------------GNDSEI---------
------YYEILSPSYSAASISPDTALSQALVAAKQATS---------------PEDK---
--------------------------------------------KRAVRYS-----MSHM
A--------------------------------------QIPVKHDSLKEEFAQLSF---
-------------------------------------NLN--------------------
---QRLSYLANMGGS--GSLGTTVDMLQEK-I-----------SSLQKSKLKEEELEIIW
GNQI------------------------------QAM-KDRYVTLDKA----------VE
KLEIRVDEFK-TLQAQIKRLEMNKVNKSTMEEE---LREKADRSALAGKASRADLES---
------------------------------------------------VALGMNEMIQGM
LFKVTIHEDKWKKAVEE----LSKDVNTKLVH-SDLDPLKKEMEEVWKIVRKLLIEGLRL
DPDSAA-GFRRKLFEHVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANSYEY---------LQRQH--MREQQ--RL----
-------------Q-RQDL---------SIQE------DYQQDWGDG-------PQNA--
ASLKCKSCNLSTLYPYGDPHMIDY-----DSAEVDILGVDGILYKGRMNSQRGAQPSV-I
AKELAA------------------VKAPC-------PP----------------------
-------------------------------------------------SQSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VHSSALLGAICPP-LCPSN-SA--HS----------AA
---SG--P-HP-----------------T--MPAR----PPSL--PPLPLLP-----PLI
PPLRD--P---------------------------QQAPGSTR-----------------
------------------------------------------------------------
-------------------------------LSRA-------------------------
-----------PHIESRVS-----------------------------------------
----------------RKPPEEPANP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSRSLLSARS-----SLSTPHLPAPKEAPKGAPREKRRGVGRVPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIVTHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGTEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSEGVISREQSRGP-----SGTGRQQQPRT---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSREKLTS----------------------------
------TLPKRDEQ--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQERGRLVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGQ--GGLVQPGV-DQLGMVQ-------------------PGADLHGLVQPGMDQ--
------DQYGLVQSGTGQGGLVQPGVDQPGMVQPGADQHGLVQIGAYPPGLVQPGMD-QH
GLIQS-------------------------------------------------------
-------------------------------------------------------G----
----PGTYPHGLVQPGADPRSLVQPGIDQHGLVQLGADQYGFV---------------QP
GIDQLGLVQRGADQQGLVQSGAVQYGVV-------------------QPGMDQHGLAQPV
----------------------QYTLMQPGAVQRGLVQPG---------------VDQRG
L-----------------------------------------------------------
-----------------------------------VPPGAVQRGLVQPGVDQRGLVPPGA
VQRGLVQPGVVQRGLVQPGVDQRGLVQP--------G-----------------------
--------------------------------------------------------VDQR
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGAGQP
GLVQPGAGQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTQAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERRDSLYRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMGGCCLPREEKPLSLFSAGFIL
FFPWSQLLAVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAR
VFLGEPRQGRAGLS-----ET--SVSRVQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQYLPRGLYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGSRR-----RCRKE-K-------TG
CGKEDPE-----------------------------------------------------
---

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------------MENSVCEAS--LYLQDQLDKLRTIIESMLSSSSTLLSLSMT--PHKST
TALVPGQIDPEATCPACSLDLGHQVSLLVQRYEQLQDMVNTLAASRPSKK--A---KLQS
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYHGLEKLEKEKADREHLFVEMDVKANKSDLESKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLVDRLLAEMDS-KLDRLELDPVKQLLEDRWKSLKQQ
LK-ERSPLYQADEAAAMRRQLL-------AHFHCLSCDRPLEMPVTGQVIPVTPVGPGLP
GHR--SIRPYTVFELEQVRQQSR-NLKLGG-SFPRGDLSQMERGVGRL--------RTMH
SKVLMD----IEKVQI-HLGVSMKASSQMIRELLQARCLDHPCYKRGAD-SADYTYSTVP
RRCGGSHTLTYPYRR-NRMQHLS----PLEEIQI----TMKHDEVDILGLDGHIYKGRMD
TRLPGILTKDSPGMTKHKSKQLQQLQ-------------------------QPQQPRPHV
H-RQQSLSNSS--------LPPSRPQSAQMLTNNP-G-SSRQKKVRPISSE-GRLSQLNI
ASPSSPTDLA--SLEGS-----QQGLDMT------MDVPPG--EGLEEPTQGSRSTTTH-
---

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-----------------------------LVH-SDLNSLKKDIEEVWKIVRKLLIEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRPVEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
N----------------------------TR-----------GL--------------SQ
V--------------------RPASANSFEY---------LQRQL--IREQQ--HQ----
-------------LHFHNF---------GVHEEGL---GPQKDWGDG-------PRNG--
TTFKHKPNDLSTVYPYGDPEIMDY-----DTAEVDILGVDGVLYKGRMNTQFGTRT---G
EKDLAA------------------VKVSY-------PS----------------------
-------------------------------------------------IQNL----S--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRPGSLLAPGYPP-LGPRTSI---SS----------GT
---TQ---HSA-----------------T--TVAR----PPSL--PPVPQLP-----PLI
P--RD--P---------------------------QEAPGPTR-----------------
------------------------------------------------------------
-------------------------------HLKS-------------------------
-----------LRLE---------------------------------------------
------------------------------------------------------------
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---

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-----------------------------------------------------MAVETLR
LIGELISLYLELKEQLKDLDEELAGQTDFEKIQYLITMIVKKTIPQDLAEQL-KSLKMLN
KEVRQDKAKLEKIQKFVDSAADTTGGKEV--KP--NHLSL-QLGIL-RVTVSDIEKELNE
LRESQDRG-KATMENSVSEAS--LYLQDQLDKLRTIIESMLSSSSTLLSMSIT--PHKST
ACLVPGQIDPEATCPACSLDVSHQVSLLVQRYEQLQDMVSGLAASRPSKK--A---KLQG
QDEELLGHVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIEV-----------------
-----------------LYQGIERLDKEKANREHLEMEIDEKADKSALASKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKLLDKLLAEMDS-KLDRLELDPLKQMLEDRWKSLRQQ
LK-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETTVTGQIISVTPMISSMP
GHR--SVRPYTVFELEQIRQQSR-NLKLGS-SFPRGDMSQMERSVGRL--------HSMH
SRMLMD----MEKVQV-HFGGSVKASSQMIRELLHTQCLSHPCYKRGAD-TADYTYSTVP
RRCGGSHTLTYPYRR-NRPQHLS----PLEEIQI----AMKHDEVDILGLDGHIYKGRMD
TRLPGILGKDTPGVTKHSKAKLQQLQQLQ----QLQQL------QQLQQLQQAQHARPHI
H-RQPSLGNIS--------SPPSRPQSAQMIADSKAV-PSGQKKDRPVSSE-GRLLQSNV
SHSSITTDMA--SLQGS-----QPGLSMH------IDVPPG--EGLEEPTRGPRSTTAH-
---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSRSLLSARS-----SLSTPHLPAPKEAPKGAPREKRRGVGRAPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-MKD---------------------------------AAEELSFARVLLQ
RVDE-------LEKLFKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQALDSA--GGLGPDQ
TA-SGSGGAAHPSDGVTSREQSSGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVFQFKSDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVIDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGTDQRSVEP----------L
GM--DQ---RGFVISGMGQQGLVAAGVDQQGLILPVIDQHRLILPFTDQHGLVSPGLMPI
SA--DRQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHALV--QPGAYQPGL------VQPGADQHGLVPPGIDQSG
LAQPGRDQHGLIQPGT-GQHDLVQSGTG---------QGGLVQPGVDQPGMVQPGRFQHA
LVQPGAYQPDLVQPDADPYGLVQPGMDQSGLAQPGRDQHGLVQSGTGQGGLVQPGVD-QP
DMVQPGADQHDLVQIGAYPPGLVPPGMGQHGLIQS-------------------------
---------------------------------------------GAFPSGWIQPDVYLP
GLVQPGTYPHSLVQPGADPRNLVQPGIDQRGLVQLGADQYGFV---------------QP
GIDQLGLVQRGADQQGLVQSGAVQYGVV-------------------QPGMDQHGLAQPG
ALQSSLGQPGAVQHGFVQPGVDQRGLVQPGAVQPGLVQPG---------------VDQRG
LVQPGAVQPG-LVQP--------GVDQ----RGLVQPGAVQPGLVQPGVDQRGLVQPGAD
-QRGLVQPGVDQRGLVQPGADQSGLAQVGAVQHSLVQPGADQRGLGQPGADQRGLVQPGE
VQRGLVQPGADQRGLIQPGVDQRGLVQP--------GEVQRSLVQPGAVQYSLMQPGA--
-------------------------------------VQ----------RSLVPPGAVQR
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QHGLVQPGMDQ--RGLVQPGAGQP
GLVQPGTGQLRMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGL----------VQP
GAYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGAY--------------------------------
-------------------QPGLTAPGTKLCGSSTFQADSTGFI--SARP---YQHGMVP
---PGREQHGQ-----------------MSPLLASQRLASPGI--DQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASPD--------------------
-----------------------PGYLSADQHGQE-------------------------
-------------------------------------GLDPSRTRAS--------DQPGI
PAQKAP-GQDVTLFRSADSL---HRVSSERSEVSSEVLSERRDSLYKMSSSFPTAVETFR
LLGELSGLYVGLKESMKDLDEEQAGQTDAEKIQFLLAQMVKRTVPSELQEQLK-TVKTLA
KEVRQEKAKVERLQRILEGEENQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQNMVNSLVVSRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIAVSGRRVAGMGPGLSVVPQ
PRSCWLFFPLFTWPPQMLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMEQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHAQCLGSPCYKRYRR-GRRGHGEQAP
S----DQAWLLPTHG-CADKCLS----P----LL----GKKR---------ECVYVKDMA
AITPTQLCPGAAGAATPSPTPTT---------------------------AAARSTHPGA
C-IPPRRS-----------RLP--------------------------------------
------------------------------------------------------------
---

---------------MSFSLTFTELANIAI--PQYGVVNFKALHLLLQGMLEHIHMGELK
KVLSGDEDFLQT-SQVLT--------------VPREGDA----Q-----------PILNP
MKRLSNVFDHVVSRVDRMETQL----AALQDLPT--------TSQLLEA---------SQ
GTSRPAQELWHLIKLRKMVEGNEEATAKSMQTLQDLLTDLHVLKVTTETLR-----QDVD
RLKDMCEKM-HPERIDIFSDDLKAQNRKMNALQRDVVRTTAPSSCL--------------
------VPDLQCPGSD----------------PLLLEPSGLWQT-EQL-------PDAAL
AQT-SEYLKAAHPSWVSEAIRSPQLLQTAWHYEVPGLLPEEE-SPQKVSVSSAQESGQSQ
ALT--PGLVSQLWP---APEPALGPSPGPAPE----PALGP---AP-GPAPGP-------
--------VVGHSVT---------------------------------------------
-----------------SGF--VTAPWPAPGAQ---------------------------
------------------------LPPSGVWPVPGGGPRPGT------------------
----------------------------------QPF-WGLRFLHPTQ----------PQ
PSRAPL----PATELDTAWPLPLQPFQPHGEGARQ---LPAVAESGEETEASLRR-----
M---SQ---DGVPKDGAQKDR---------------------------------------
-------------------------------KAKDRARKDAAPKDRAPKDGAPGEAQRKG
PQAAIQRIRTATAIAAAAAAAYAA-AANSAARAAKVAAKAVKDAPATKLATIATTMATSG
PLGVSADILGAGPSRG-----LEDVPID--------------------------------
-------DDILSPPYYA-VTTPEVTLSQAML---QATS---------------PEDK---
--------------------------------------------KKAVRYS-----MSCM
A--------------------------------------QIPIQHDSLKEEFAQLSS---
-------------------------------------SLN--------------------
---QRLTYLANMGSS--SGLGPTVDILQEK-I-----------GNLQKSRLQGEELERVW
GHQI------------------------------EMV-KDHYTVLDKA----------VE
RLEARLDEFK-MLQAQIKGLETSMVNKSVMEQE---LKEKADRSTLASKANRADLET---
------------------------------------------------MATELNEMIQGM
LFKVSAHEHDWKKTMER----LRKDVSTRLVH-SDLDSLKKEMQEIWKVLQRLLVEGFRF
DPDSAA-GFRKKLFERVKCI-----SCDRPVEMMTS------------------------
------------------------------------------------------------
-----------------------------------------------------PQLITIR
K----------------------------AH-----------LL--------------SR
L--------------------RPASANGYEY---------LQRQQ--MREQQ--RL----
-------------Q-LRDL---------RIRES---LDSCQQDWGDG-------PRND--
ANLKHKSYNLSTLYPYGDPELIDY-----DTAEVDILGVDGILYKGRMNNQNVAQPSATM
DKELAA------------------VKVPC-------PP----------------------
-------------------------------------------------SRSL----Y--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------AGSSASLGAIYPP-LCPRT-ST--YS----------DV
---LG--S-HP-----------------M--MPAR----PPSL--PPLPLLP-----PLV
PHPRD--P---------------------------QQAPGPAR-----------------
------------------------------------------------------------
-------------------------------PLRP-------------------------
-----------LRLESRAS-----------------------------------------
----------------KQPPEEPTNP----------------------------------
------------------------------------------------------------
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---

---------------MSFSVTFSELANIAI--PQCGVVNFKALHLLIQGILDHIQISGLK
KVLSGDEDFLQT-SQVVI--------------MPREGEA----Q-----------TIINP
MKRLSNIFDTVVERINKIENQI----SSMQTMPT--------TTSLLEA---------SQ
GTSRPAEEMWNTIKLLKRIEAIEEVTAKFMKTLQDLLNDLYILKRTVETLQ-----KDVD
LMKFIFGKV-NPEKMELICEDLKVQNRKLGALQREVVTLQDKVGAIPEPKDMVLWSG---
LHEAMFSPVN---------------------QTVN------WSSSLQR-------SKEE-
----------LGQFED--EDHIAHPTKTFMPVGTTGPLERQE-FAQADEFRGPLGLQQTR
--VSMT-----------ETVP------G------------------------P-------
--------SFGPEL----------------------------------------------
-------------------------------------------------AVPGLPGA-LP
GALPGAWP---GAP----------GAWPGAWP--GAWP----------------------
--------------------------------------------GPGLRPFGPQG----Q
MYRAPF----PAMEAGPQHQVPKTG--------TP---LSD-----LEERDEYEY-----
G---YM---EQVPRDGAPQDGVPKEEAPQDGVTKEEAPQVGVPKERAPQDGVPKEGAPQD
RAPKDRVHH-----HRAHRRRVPKDG-----APQDSASKDTVHKDKEQKDKTP-EAQSKH
SLSALKKLKSVASVAAATAAAYAA-AANTAAQRATAALKAIKD-PESKLASSASTMAAGG
PLEAFADFLGSGTSPG-----ATDIIPY-----------------SDDEL----------
QEL----VETL-TPAT-RPTTPRSALSQAMVTASQAVS---------------PEEK---
--------------------------------------------KAAVQYS-----MSHL
A--------------------------------------QMPVRHDSLKEELVHLST---
-------------------------------------KLN--------------------
---QRLDYLAKMGSS--GKLGNAVNVLEEK-I-----------CNLQKARLEEEELERIW
GHQI------------------------------ETM-KSHYIVLDRT----------VE
KLQIRMDDFK-TLKAEIQRLDLIKADKTMMEQE---LREKANRDALASKASRTDLEV---
------------------------------------------------VATELNEIVQSM
LLKITTQEDDWKKSLKQ----LRKDLNTKIVH-SDLNSLKKDIEEVWKTLRKLLIEGLRF
DPDSAA-GFKKKLFERVKCI-----SCDRKIEMMTG------------------------
------------------------------------------------------------
-----------------------------------------------------PHLITIH
N----------------------------TH---------------------------WK
V--------------------RPASANSYEY---------LQRQL--MREQQ--QQ----
-------------LHYQNF---------GVHEEGL---GSQKDWGDG-------PRND--
TTFKHKSHDLSTIYPYGDPELMDY-----DTAEVDILGVDGVLYKGRMNSQFGTRT---G
EKDLAA------------------MKVSS-------PS----------------------
-------------------------------------------------VQNM----N--
-----------------D------------------------------------------
------------------------------------------------------------
-----------R----------VRSGSILTSSYPP-LGTRTSSA--TT------------
--------YLH-----------------S--PSGQ----PPSL--SPVQQLP-----PLM
PHSRD--P---------------------------QEAPASTR-----------------
------------------------------------------------------------
-------------------------------HLKS-------------------------
-----------LRL----------------------------------------------
------------------------------------------------------------
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---

---------MPP----ATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQNTR
IDFQAPSPEPSHSLLSARS-----SLNTPHLPAPKEAPKGAPREKRRGVGRVPPSALESQ
VKDLGGQVEDLSKQLKRVDSQMQGIATHVQRFSQASG-LDLASQEWPEEQEVAMQVLDRV
RTGS-----I-LKD---------------------------------AAEELSFARVILQ
RVDE-------LEKLLKDRE-----------QFLELVSRKLSLVPGAEEVTMVTWEE---
LEQAIT---------------------------------DGWRASQA-------GSETLM
GFS-----KRRGF--TSL--TSPDG-TLSGAST------KQPSIDQVLDSA--GGLGPDQ
TA-SGSGGATHPSEGVISREQSRGP-----SGTGRQQQPRA---RD-EAGMPR-------
--------LHQSSVLQFKPDSDRRRSREKLTS----------------------------
------TLPRRDER--------DARPGPVQQDLTSARE-----------QPSRVPAS-QS
QVHL--RSDRRG-----LEP---TGMDQPGLVHAGTYLHGVVPLSMGQ------------
----------------------------------------LRVPPPEMDDQEWGRLVMDE
-QRMLPPSVPGRDQQGLELPSTDQHGLVSVGAYQHGMVLPGIDQRSMEP----------L
GM--DQ---RGFIISGMGQQGLVAPGVDQQGLILPVIDQHGLILPFTDQHGLVSPGLMPI
SA--DQQGF------------------------------------VQPSLEATGFIQPGT
EQHDLIQS--------GRFQHAVV--QPGAYQPGL------VQPGADQRGLVRPGMDQSG
LAQPGRDQHRLIQPGT-GQHDLVQSGTG---------QGG--LPGMDQSGLAQPGR----
------DQHGLVQSGTGQGGLVQPGVDQPGMIQPGADQHGLVQIGR---G----------
------------------------------------------------------------
------------------------------------------------------------
-LVQPGEVQHGLVQPGADQRGLVQPGADQRGL----------V---------------QP
GVD----------QRGLVQPSEVQRGLV-------------------QPGAVQYTLMQPG
A--------------------VQRSLVQPGAVQRGLVQPG---------------VDQR-
------------------------------------------------------------
-------------------------------------------GLVQPGVDQRGLVPPGA
VQRGLVQPGVDQRGLVPPGAVQRGLVQP--------G-----------------------
--------------------------------------------------------VDQR
GLVQPGVD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------QRGLVQPGVDQ--RGLVQPGAGQP
GLVQPGAGQLGMVQPGIDQQGLVQ-----PQADPRGLVQPGAYPLGF----------VQP
GVYLHDLSQPGTYP----------------------------------------------
--------------------------------------------------HGLVQPGM--
-----------------E-RYGLR------------------------------------
-----------------------QSGTY--------------------------------
-------------------QPGLTAPGTKLRGSSTFQADSTGFV--SARP---YQHGMVP
---PGREQYGQ-----------------MSPLLASQGLASPGI--NQRSLVP-----PET
YQQGLMHPGT--DQHG--PIPLSTGLGSTHPDQQHLASLDPGK--HEQVHPDAAQHGCA-
------FSLSLSPDSMCP-GYGGPGYLSADQHGQE-------------------------
-------------------------------------GLDPNRTRAS--------DQPGI
PAQKAP-GQDVTLFRSPDSL---HRVSSERSEVSSEVLSERHDSLYRMSSSFPTAVETFR
LLGELSGLYMGLKESMKDLDEEQAGQTDMEKIQFLLAQMVKRTVPSELQEQLK-TVKTLA
KEVRQEKVKVERLQRILEGEGTQEAGKEL--KA--GELRL-QLGVL-RVTVADIEKELAE
LRESQDRG-KAAMENSVSEAS--LYLQDQLDKLRMIIESMLTSSSTLLSMSMA--PHK-A
HTLAPGQIDPEATCPACSLDVGHQVSMLVQRYEQLQDMVNSLVISRPSKK--A---KLQR
QDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIA------------------
----------------MLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRIQFDAT
TEQLNHMMQELVAKMSGQEQDWQKMLDKLLTEMDN-KLDRLELDPVKQLLEDRWKSLRQQ
LR-ERPPLYQADEAAAMRRQLL-------AHFHCLSCDRPLETPVTGHAIPVTPAGPGLP
GHH--SIRPYTVFELEQVRQHSR-NLKLGS-AFPRGDLAQMKQSVGRL--------RSMH
SKMLMN----IEKVQI-HFGGSTKASSQIIRELLHSQCLGSPCYKRVTD-MADYTYSTVP
RRCGGSHTLTYPYHR-SRPQHLPRGVYPTEEIQI----AMKRDEVDILGLDGHIYKGRMD
TRLPGILSKDSSGTSKRK----------------------------------SQQPRPHV
H-RPPSLGGNG--------HLPSRPQSAQMSRGGPGSGR-----RCRKE-K-------AG
CGKEDPE-----------------------------------------------------
---

Query Results

"ENSGT00910000144214_0"

ENSGT00910000144214_0