ENSGT00910000144083_0 : Linker Region Query Results

------------------------------------------------------------
------------------------------AAKVEGQDRILL----SIVQSLEKICF--N
FG---NGLHLEVLNT-GNDNALLPK-HT-----HSVRQKRAWITAPVALREGEDLSKRNP
IAKIHSDIAEEKGLKITYKYTGKGITEPPFGVFVFNKNTGELNVTRI-LDREETPSFLLV
GYALDE--RGNNLEKPLELRIKV LDINDNEPVFTQDV FAGSVEELSASDTLVMKISATDA
DEPNTLNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSFTLDRE----EHSSYTLTVEAR
DGNGQVTDKPVKQAQVQIRI L-DVNDNIPIVTNEM TE--GV-VEENQANVEVMRI---KV
FDADEIGSDNWLANFTIVSGNEMGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEIK
NLDFSITVTNKAAFHKSV-KNKYKATSIPFKVKV KNVKEGIHFKSST ISVHVSE--SMDK
SSQSQIIGKFQAFDEDTGQLA-HV-----KYAKLEDVDNWISVDSVTSEIKLVKIPDFES
RYVRNGTYTAKILA--ISE--SYP-RKTITGTIVITVGDINDNCP-TLIDPVQTLCD---
D-MPYVNVTAEDLDGSPNSGPFSFSIIDKPAGTA-EKWQIVHQES--TSVL---LQQKEQ
KLGRSEIQFLISDNQGFSCPEKQVLKLT--VCKCLNGGGCVEA-----------------
------------------------------------------------------------
---------------------------------------LHDSYVGLGPAAIALIIFALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPLPVTA-----DHGECVAVDTR
VG-----GVTTKETM---K---------ESRSAFIRGQHEVAEVD--GRWEEHRSLISGG
VTE--VTGTTGAN-IGAGTTRTTKV----T-----GSSRD---------LA---------
-G----AR-------------------AAAVAVN-EEFLRNYFT----------E---KA
ASYTDEDDIHIGKDCL---LVYSQED-T--------ASLHGSIGCCSFIE-GELDDRFLD
D-----LGFKFRTLAEICSGQKI-DMDGEIEQR--QKPVGE----------SST-KAASH
SFSEQTRINS-------------------EHAYF--SDSSFQ-----------------V
PKP--LHE---ANAEKVTQEIVTESSV-SSRQSQKVATLL-PDPLASGNV-VVTETSYAT
-GPTVP----PSTVILGPGQSQALIVTERVYAPAPPLA-------------DQH-YANDS
SVLVT--------------------------ERIIQPNGGLPGPLEGSQHLPDARYVMVR
ERERFLAPSSGLQPP-LAAPAA-AVGQNVIVTERVR------------------------
-------TP----ASSYQF---PAETSMMARK-----T-----EVSGA--TVHGPLPNF-
--------------------SLEESGRSNS-------------------AQTISSTRISK
HGIVQHSYS----------------

------------------------------------------------------------
--------------------------------WLLNFVLCLYML---IILSFLQVFL--D
FS--TG-FHVEV-KE-WSENGTAR-WKT------FRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEENN--PITYSISGVGIDRAPYGIFVINPRTGDINITAI-VDREVTPVFVIR
CFAKHS-VTGIDLEPPLELRVRV LDINDNPPIFAQSV FTGAVEECSMDNTLVMKIIASDA
DEPNNLNSKIAFKIESQEPSGPPMFVMKKATGELH-LANYLDRE----QHSSYTLVVKAS
DRDGAGDGI-SSLCSCHVKV I-DVNDNFPTLAQSS FS--AA-ISENSLSSELLRI---QA
LDADEEFTDNWLAEFFFISGNEDNCFEIVTDPATNQGILR-VI-----------------
---------------------------------------------------KELNYEQIR
THSLSIGVRNKAEFHHSV-MSQYQVIGTPLIVEV KNVIEPPRFNPSS IIFFVSQK-----
MRANYVLGTYTAFDEDTGTTATNV-----VYSIGRDPGAWFRINQNTGEITLNKVIDWES
SYVSHGQYRAEVLA-ITRG---VP-QYTATGTIVLTMQGVNDNCP-TINTALRKVCM---
H-SPSVVITAKSVNGDLYGLPFTFSIHG-EPQ---TTWIIRSINAKATSAE--LV-SQNM
DFYLYKIYIRVRDSQGRSCLQPYIIPLQ--ACRCDSRNYCSSGATKIIIIGGGDGGGGPD
-----------------------------------------------DDRIGWT------
-------------------------------------------GSTLSGAAIGLMFLGGL
----IFV--LIP-----IL----------MSMSDCC--GCGP-GAAAG--VGTGFEPVPE
CT-------EGAIHP---W-GIEGAQPEDRD------VSHILAPTTAA------------
-------------------------------GGDFGEPSVFSDIY--------TNTYGGG
G-G--VC-----H--GVE----E------TTGVGYATGTGYGTAG-------------GV
S--GTGEVKGST-GGTIKEYREG-G-------VN-MAFLDNYFS----------E---KA
FVYADEDEGRPANDCL---LIYDHEG-I--------GTPVGSVGCCSFIG-EDTDETYLD
T-----LGPKFKTLAEICLGKEI-EPFPDVNP---PWPGS--------------------
---------------------------------------------------------APM
APP----------VGT--TTVVTENTY-TSASTIQPPRPM-PDPLLH-GNVTVTETYTSG
--S--------P--CVDPLRASNVVVTE--------------------------------
---------------------------------------------SI-PDLVDGSNVVVT
--ERVFRPASGMPGSLINIPSELSNTHNVVVTERVVSG-SGMTGLAGG------------
--------------GLG-------------------------------------------
---------------GANLGGLSSTGQM-LNTDCHLGQA-----MGTASPGT-SRRRVTK
YSTVQYSSQ----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMERSS YD--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTGREES----------T-------------SSTDYETSTIYTL
SQ------------------P-----VTSTAYQN----GVVADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGTGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSTSPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--IA------AVLFIFLVVI--E
VN--SE-FRVQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPADAPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECSIKI L-DVNDNIPYLVLPEIS--IK-IEENTLYTNLMEI---RV
IDLDEEFSANWMGVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVN
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVAVLNQREGPVFRPGSKTYIVTGN-----
MGANSKVGDFIATDQDTNGPSTT---AR--YVMGNNPADLLAVDSRTGIITLKNKVTRDQ
YNMLGGKYQGTILS--IDD---DL-QRTCTGTININMEGFDFSHS---------------
-----------------------------------------DTTT--N------------
-----------------------------------------------------AGGNTDD
N--------------TNTNTGSN----------T-------------NASRDDTSTQQGS
NT------------------------NTLEG---PNGIAVISDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCDGAA--TR--SVGGFEPVPE
CS-------DGAMHV---W-SEEGPQLDPTN-----TV----CVPPI----SG-------
------------A-------------------TNLIEFVDNSGVY--------TNEYDGR
KMH-DLGGGERV-----ELREEVNMSGMP------------------------ETCQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDLDP---SWPPQSTEPVCPPQET--------E
PM------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-PDPLGY-GNVTVTESYTTS
-D--TLK---PSVHIHDNRQASNVVVTERVVGPISGVD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTF-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELGNAHNVIVTERVVSG-TGVTGISGTSGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGSGMGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTMQYSK-----------------

------------------------------------------------------------
------------------------------MAWRLF---RTT-----GALAILMVVL--L
VH--GE-LRIETKGQ-HGEYETEVQ-QA------KRRYKREWVKFARPCREGEDNSKRNP
IAKITSDFQATQ--KITYRISGIGIDQPPYGIFVVDKNTGEINITAI-VDREETPSFQIT
CRALNA--LGQDVEKPLILTVKI LDINDNPPVFSQSVFM GEIEENSASNSLVMMLNATDA
DEPNHLNSKIAFKILSQEPAGTPMFLLSRHTGEVRTLTSSLDRE----QISSYRLVVSGA
DKDGEG--L-ASQCECSIK VK-DVNDNFPRLRESQYI--AR-IEENTLSSDLLRL---QV
IDLDEEFTDNWLAVYFFTSGNEGKWFEIETDSRTNEGILK-VV-----------------
---------------------------------------------------KSLDYEQLQ
SVQLGIAVKNKAEFHKSV-ISQYRVQSTPLTIQ VINVREGIAFRPASKTFVVQQGI-SSR
K LINYVLGTYQAIDEDTNKAASSV-----RYILGRNDGGLLIIDSKTAQIKFAKNIDRDA
TFIVNRTITAEVLA--IDE---NT-GKTSTGTVYVKVPDFNENCP-TIALEKETICS---
S-SPSVVVSARAVDKDKFTVPYTFSLEDQPLKLP-VVWSIASLDD--TSAL--LRAPQQI
SPGVYRISLVVTDSQGRRCETPESLTLE--VCQCDSRDTCGTPVPTKTP-----------
------------------------------------------------------------
-----------------------------ST------ENGKTSSWRLGPAAIGLLLLGLL
----MLL--LAPLLLL--------------------TCDCGR-GPIGG--VTGGFIPVPD
GS-------EGTIHP---W-GIEGAHPEDKE------ITNIRVP-PIS------------
-------------------------------SNGVDF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTKLGAAGGSGAAAGF------------GAAAGLSIYSAGQ
S--GTMRTRHS-TGGTNKDYGEG-A-------VN-MNFLDSYFS----------Q---KA
FACAEEDDGHEANDCL---LIYDNE--G----TGVPGSPVGSLGCCSFIA-DEWDDGFLD
S-----LGPKFKKLAEISLGMDD-EAKKSQPP---AKDSGSGVESCGQ----SVQVQQS-
------------------------------------------------------------
---------ESVCYQTLSGSQGASALS-ASSSVLQPAISI-PDPLQQ-GSYLVTETYSA-
SGS-LMQ---PSTAVFDPLLTQNVIVTERVICPISSVP---GNLHAPT------ELPGSC
NQICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLYLQISST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRLLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARSPGSRCAL------LLLQLLLICS--D
FG---NGLHLEVLNT-RSENKLLPK-RT-----HLVRQKRAWITAPVTLREGEDLSRKNP
IAKIHSDIAEERGLKITYKYTGKGITEPPFGIFVFDKNTGDLNITSI-LDREQTPFFLLT
AYALDS--RGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSVEELSAAYTLVMKITATDA
DEPNTLNSKIAYRIVSQEPTNPAVFHLNRETGEIYTTSVTLDRE----EHSSYSLIVEAR
DDDGKITDKPVQQAQVQIQI L-DVNDNIPVVESEM YE--GM-VEENQVNVEVMRI---KV
TDADEIGSDNWLANFTFASGNEEGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KELDYEKMK
TLDLSVIVTNKAAFHKSV-RDKYKPTPI PISIKVKNVPEGIHFKSSTISVWASE--GMDK
SS QSRTIGKFQVFDEDTGQAA-NV-----KYAKVEDIDNWVSVDSVTSEIKLVKIPDFES
RYVQNGTYTVKVVA--ISD--DHP-RKTITGTVLITVEDINDNCP-RLVEPVQNICN---
D-APYVNVTAEDLDGPKNSGPFSFSIIDKPPGTA-EKWKITHQES--ASVL---LQPSEQ
KLGRSEIPLLILDSQGLSCPERQVLQLT--VCECLRGGGCAEA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAVALMILAFL
----LLL--LVPLLLL--------------------ICHCGEGAK--GF------TAIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVV-----DHE-NSGVRNG
VG-----GAMLKEST-MKG---------SSSASVTKGQHEFSEVDGHGRWEERRSLLTSG
TTH--VIGAAGAN-TGSEALRITRT----T-----GASRD---------MS---------
-G----ARK------------------G-AVAVN-EAFLRNYFT----------E---KI
ASYAEEDDLHMAKDCL---LVYSQEE-T--------ESQRGSIGCCSFIE-GELDDRFLD
D-----LGLKFRTLAEVCLGQKI-DLDMDVEQR--QQPVRD----------AGV-NPEAH
SHYTQTTVHS-------------------EKAYS--SDGSFP-----------------V
PKP--RRQ---AHADRVTQEILTESSV-SSRQTQKVVPPL-PDPVAASNI-IVTETSYAT
-GSTVP----PSTVILDPGQPQSLIVTERVYAPASTLV-------------DQH-YTNEG
NVLVT--------------------------ERVIQPNVGVPNPLEVTQHLKDAQYVMVR
ERESVLAPSSGVQPT-LVP-SSVATGQNVTVTERVL------------------------
-------APASTLQSGYQM---PSEASVKARK-----T-----VVSRT--GFPDPLPNL-
--------------------DSEESGHPNS-------------------AVTTSSTRVTR
HSTVQHSYS----------------

------------------------------------------------------------
----------------------------------------NL-----TLFKYLQVFV--L
VH--GE-LRIE---P-HGKEETAVQ-QG------KRRYKREWVKFATPCREREDNSKRNP
IAKITSDFQTNQ--KITYRISGVGIDQPPFGIFIVDPNTGEINITAI-VDREETPSFLIT
CRALNV--LGQDVEKPLLLTVKI LDVNDNAPVFSQRIF KGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTPMFLISRNTGEVRTLTNALDRE----QFSSYRLVVSGA
DQDGVG--L-STQCECDVK VK-DVNDNFPVLKYSQ YS--AR-IKENALSSDLLRF---QV
TDWDEEYTDNWRAVYFFTSGNEGKWFEIETDPRSNEGILK-LV-----------------
---------------------------------------------------KPLDYEQMQ
SMRFSIAVKNKAAFHQSI-VSQYRVQSTPVTIEIIDVREGISFRPASKTFTVQKGI-SSS
KLINYVLGTYEAIDEDTGRAATSV-----RYIMGRNDGGLLIIDPKTAQIKFVKNIARDS
TFIVNKTITAEVLA--IDE---NT-GKTSTGTVHVEVPEFKESCP-PVVLEKEEICS---
S-SPSVVVSARTLDRDRYAGPYTFSVEEQPLKLP-VIWRITGLNA--TSAL--LEAQPQI
SPGVYRVPLVVTGTQDRQCESSEMLTLT--VCQCDARGSCRASGTDPHI-----------
------------------------------------------------------------
-----------------------------E---------LRKQQSRMGPNAIGLLLLGLL
----LLL--LVPLLLL--------------------TCDCQ-RGPAGG--VAGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIA------------
-------------------------------TNGVD-IVESSEVC--------TNTYTGG
T-V--VEGA---S--GMELATKVRATTESGAVTGF------------GAATGLGPCPPGH
LGLGTLRSRHS-TGGTLKDYAEG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEEGVQEENDCL---LIYDNEG-P----DDVP---DSPLGCCSFII-DDFDDSFLD
S-----LGPKFKKLAEISLGIDG-GAKQAQLP---PQYSGTGVDVCVQ----SGEAQQ--
-----------------------------------------------A-GR---ERYQTL
VQPGEAQQAGRERYYTLQGGQEAPALS-TYGS-LQTAIPI-PDPLQH-SNYLLTETYSA-
SSS-FAQ---PTTVAFDPLLTQNVTVTERVICPLSSVP---GST----------DLRGSY
SMLCT--------------------------ED-----------PC--------------
--SRQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILFMVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILK-LV-----------------
---------------------------------------------------KMLDYEQEP
NIYLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVINVREGPTFRPSSMTFSLRGGM-RGD
SLMNYVLGTYTAIDMDTGSPATNV-----RYVIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGMYAAEILA--IDD---GS-GRTATGTICIEVPDANDYCP-VIYAESRSVCT---
H-ASSVRIYV---NDHSFGAPFTFCVVDESPDTA-DIWDIRSING--TSAI--LMTEQTL
SPGPYQIPILVKDSHNRACELPQTVLLD--ACLCDDYHVCLHSSTTGIYTGDT------I
------------------------------------------------------------
---------------WVTDDM-GT----------VTDDGLRQSNVGLGPAGIGMIILGLL
----LLF--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TAAGIAAGG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-T--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAAASEPMIH-GDIIVTETYTAT
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGVPDMGNGNIGDT-------
--------CIGPVMSGG---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PDIHISQT-----TRSTSPMT-SQHRVTR
YSNIHYSRQ----------------

------------------------------------------------------------
------------------------------------------------------VVV--E
VN--SE-FIVEVKEL-DMENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPIFLIY
CRAL--NSRGEDLESPLELRVKV MDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDDHLNSKIAYKIISQEPAGAPMFVLNRHTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPSLEKTS YS--AS-IEENCLNSELIRL---QA
IDLDEEGTDNWLAEYLILSGNYGNWFDIQTDPQTNEGILK-VVKVHISQAERAEEKIQAS
SCNT----EGFYGENIK------QHGNIKRIWKEYTKSVYQKELVEVQPFQEALDYEQMP
SIHLSIGVKNRAEFHHSV-ASQFQMHATPVRIQV VNVREGPVFHPNS MTFSVRDGT-RGD
SLLNYMLGTYTAIDLDTGNPATNV-----RYITGRDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-GKTATGTICIEVPDINEYCP-VIFTEGGTICI---
A-SPSVLIFARGIDNHSYGSPFTFCVADWPPGTA-DLWDIRSINA--TSAI--LTAVQPL
FPRLYYIPIIVKDIYNRACESAHTVQLD--ACECDSNHMCLYPSTTSIYTGDI------G
------------------------------------------------------------
---------------TITSDVYWS----------VTDDRIGESNVGLGPTGIGMIILGLL
----LLL--LAPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLVGGG------------------------A
A--EATRKRSS-TIGTLREYAES-G-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESSMA
T-----LDPKFRTLAEICLDTEI-EPFPS-YQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAV-PEPSIP-GDIIVTETYNTA
--DQSVQ---PPTIVFDPQLAPNVVVTETVMAPAYDVQ---GN-----------------
------------------------------------------------------------
----------------ICIPAELANTHNVIYAERVLSS-PGMPGMSSSSVADG-------
--------FMGPMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRHRVTQ
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MTCLFP---RAL-----GPLALLMVVL--L
VH--GE-LQAEPGGQ-PSEDRTAVQQ-A------KRRHKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLILTVKI LDVNDNAPIFSQTIF NGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMPMFLISRNTGEVRTLTSSLDRE----QISSYRLVVSGA
DNDGAG--L-SSQCECSIK VK-DVNDNFPVLRDSQ YS--AR-IEENTLNSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
SMQFSIAVRNKAEFHQSV-ISQYQVRPTPVIIQV TNVREGISFRPPSKTFTVPRGV-ST N
KLAGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAEIKFVKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVLVEVPSFSENCP-SVVLEKEEICS---
S-SPSVLVSVRTLERGRYTGPYTVSLEEQPLKLP-VMWNIRTVNA--TSAR--LQAQQQV
SPGVYSVPVIVKDNEGGQCDTPEILTLT--VCQCDDRNLCRSPNPSREP-----------
------------------------------------------------------------
-----------------------------IL--------YRESSWGLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGA-GPIGGGAATGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PTT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V--AEGA---S--GMEMTTKLGAATGSGA------------------AAALGPCSLGH
S--GTMRTRHS-TGGTLKDFVAA-P-------VN-MTFLGSYFS----------Q---KS
FAYAEEEDEREVNDCL---LIYDDEG-E----DAAPCS----LSSCSFIA-DDLDDSFLD
S-----LGPKFKKLAEICLGIDD-EAKQARPG---PKDRASGADVCAR----STEVPQSG
SSRYQTVPGSVEVPQSGSQRYQT-------------------------------------
----------------LPGSQVSSVLS-PSGS-VLPAIAI-PDPLQL-GNYLLTETHAT-
SGS-FVQ---PTAATFDPHLTQNVTVTERVICPLPSVS---GSLVAPT------ELRGSY
SMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MNWPFFR--TA------AVLFIFLVVL--E
VN--SE-FQIQVRDY-NSKNGTIK-WRS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRAVDS--LGQDLERVLELRVRV LDINDNPPVFSMST FLGQIEENSNANTLVMMLNATDA
DEPNNLNSKIAFKIVRQEPSDSPMFIINRYTAEIRTMNTFLDRE----QYGQYSLVVRGS
DRDGGADGM-AAECECSIKI L-DVNDNFPYMEQSS YS--IS-IEENVLNSNLLQI---RI
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLK-VI-----------------
---------------------------------------------------KALDYEATK
NLQLSLGVRNKVEFHQSI-KSQYKLTATAVSVTVLNVVEGSVFRPGSKTFVVTRE-----
MGQNYQLGDFIATDLDTGLPSTTVXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXX-
XXXXXXXXXXXXXX--XXX---XALQKTSTGTIIIKLESDSGKDG---------------
-----------------------------------------APSN--D------------
-----------------------------------------------------NNTSTSR
NG------------LTSS---------------DVTIDTNKNVGTV--------------
-------------------ST-----NTFGVGGTTAFRSIKEDNVYFGPAGIGLLIMGFL
----ILGXXXXXXXXX--------------------XXXXXXXX--XX--XXXXX-----
-X-------XXX------X-XXXXXXXXXXXXXXXXDLTNIGAPQIP----PN-------
------------N-------------------ADTIECIDNSGVY--------TNEYHGR
KMQ-DLGGGERTT--ALELVDGVKTSGQP------------------------KICQ-EY
S--GTLR-------SSVRDCREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEARPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKGV-EPYLDPDP---SWPPDSTEPICPLQGT--------E
PI------------------------------------------------GSG---HPHT
SPH----------FG--TTTTISDSNY-PSGPGVQHP--I-PDPLGY-GNVTLTESYTTL
-G--TLK---PSVHVHDNRHASNVVVTEKVVGPISGAN-LHGML------EMPDFRDGS-
NVIVT--------------------------ERVITPGSSLPSTLTI-PDPRESSNVVVT
--ERVIQPTSGLVGN-LSVHPNLSNTHNVXXXXXXXXX-XXXXXXXXXXXXXX-------
--------XXXXXXXXXX-----XXX-------------------XXX--XX--XXXXXX
X-------XX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXT-ARSRITT
YSTGQYTK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--TA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKIGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIVNQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTFL GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEVRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGL-SAECECSIKI L-DVNDNIPYMEMSS YA--IT-IDENALYSDLMQI---RV
IDLDEEFTANWMAVIFFMSGNEGNWFDIEMNERTNVGTLK-VI-----------------
---------------------------------------------------KPLDYEAMN
SLQLSIGVRNKAEFHQSI-M SQYKLTVTAISVTVSNVIEGPVFRPGSK TFVVNSN-----
MGSNYKVGDFVATDLDTGLASTT---V--RYVMGNNPADLLTIDSKTGVIMLKNKVTREQ
YNMLNGRYQGTILS--IDD---NL-QRTCTGTINIDLQGSNWPAR---------------
-----------------------------------------DSTS--T------------
-----------------------------------------------------N------
-------TSTDTGTNTGTSV----------------------------------------
-----------------------------GGGAGVGQGGILSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----LA-TICVPQIP----SD-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGER-T--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADITLGKEI-ASYPDPDP---SWPPQSTEPICLPQEP--------E
PF------------------------------------------------VSG---HPPI
SPH----------FG--TTTIMSENTY-PSGPGVQHPMSI-PDPLGY-GNVTVTESYTTS
-G--NLK---PSVHIHDNRHASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-PHPREPSNVVVT
--ERVIQPTSAMMGS-LSMHPELANAHNVIVTERVVSG-TGVTGISGTAGIS--------
--------GGGGLGSSGL-----VGTS-----------------MVGA--GVSGGGIGLS
SLGGGGGLSS-------SMGGAATMAHMRGSADHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------------------------------ICL--D
LG---NGLHLEVLNA-RGEDK-LPK-HT-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERGLKITYRYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDV--RGNNLEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKITATDA
DEPNTMNSKISYRIVSQEPTNPSVFYLNKDTGEIYTTSVSLDRE----EHSSYSLTVEAR
DGNGQITDKPVHQAQVQIRIL-DVNDNVPVVEHEMYE--GV-IEENQVNVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KVSRGCSQL
GWESGCGGL---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
---------------------------------TIQL---K------INYCDYLVMA--E
VN--SE-FRIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPYFIIV
CRALNS--QGQDLERPLELRVRV LDINDNPPVFSMATFI GQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECDCNIKI L-DVNDNIPYLEKSS YS--IE-IEENALHSDLDQI---RV
IDLDEEYTDNWVAVIFFISGNEGNWFEIEMNEKTNVGILK-VV-----------------
---------------------------------------------------KPLDYETMN
NLQLSIGVRNKAEFHHSI-MAQYKLTATVISVSVKNVVEGSVFRPGSKTYVVTSN-----
MGANSKVGDFIATDLDTGLASTT-----VRYVMGNNPADLLAVDSKTGILTLRNRVTMEQ
YQMLNKRYQGTILS--IDD---SL-HRTCTGTIIIDLEGSGWVTE---------------
-----------------------------------------DSSS--T------------
-----------------------------------------------------QGGSSNT
------------GTTSENTTEDSSGGGTSTN-----------TGG--QSSSDD-------
--------T------DVNNE----------ENGDKNGGAYNGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPH------DLATICVPQIP----PG-------
------------G-------------------ATMMECIDNSGVY--------TNDYCAR
EMQ-DLGGGERMT--GFELIEGVKTPAAP------------------------EICQ-EY
S--GTLRR------NSMRECRE--G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSKDCL---LIYDNEG-V--------DSPAGSVGCCSFIG-EDLDESFLE
T-----LGPKFKKLADITLGKET-VCYPDPDP---SWPPQNTEPIYPQQTT--------G
LV------------------------------------------------ASG---HQQV
SQH----------VG--ATTVISENTY-PSGPAVHHPMPI-PDPLGY-GNVTVTESYTTS
-G--ALK---PSVHLHDNLHAPNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PTPIEPSNVVVT
--ERVIQPTSGMMGN-LSMHPDLSNAHNVIVTERVVSG-AGISGISGAAGLSG-------
-----------GVGSSGL-----VSTNMGVSG----------SGLS--------------
-----GGLSG-------TMGGTATISHMRNSSDHHFTQP-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWHFFR--TA------AVLFIFLVVV--E
VN--SE-FQIQVRDY-NVKNGTIK-WHS------IRRQKREWIKFAAAIREGEDNSKRNP
IAKIHSDCAANQ--QVTYRITGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPIFSMST FVGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGIDGV-SAECECSIKI L-DVNDNIPYMQQSS YS--IS-IQENALYSDLLQI---TV
IDLDEEYSDNWIAVIFFVSGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NVQLSIAVRNKAEFHHSV-MSQYKVTATAVSVTV ENVIEGPVFRPGSKT YVVNSK-----
MGANYRVGDFVATDLDTGLPSTT---V--RYVMGTNPGNLLAVNSRTGAITLVNQVTREQ
YDMLGGKYQGTILS--IDD---AS-QRTCTGTIIIVLEGSDWGGS---------------
-----------------------------------------GGTS--T------------
-----------------------------------------------------TTST---
--------GSSTGGGTDSGTGV----------RY-------------TPTNYDTTS----
-------PSD-----R-----------ENGHTPSINPLRNPIDNVHFGPAGIGLLILGFL
----LLG--LVPFLLT--------------------YCDCGGA---AG--DRAGFEPVPE
CS-------DGAIHS---W-GVEGPQPELRD-----LTTAVCVPQPL----PD-------
------------N-------------------ANIMECVDNTGVY--------TNEYCAR
EMQ-DLGGGERAS--GFEVTSGVKTSGGP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKGA-DSYPDLDP---SWPPEHTEPVCPQQGT--------E
PT------------------------------------------------TGR---YPPI
SPH----------FG--TTTVISESTY-PSGPGAQHPIPI-PDPLGY-GNVTMTESYATS
-G--TLK---PSVHLHDNRQASNVVVTERVLGPISGAD-LHGML------DVPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLII-PDPREASNVVVT
--ERVIRPTSGVTGT-LGMHPELSNAHNVIVTERVVSG-SGIAGISGTAGIS--------
--------GSSAG------------------G----------GGLSAA--GVSGGGIGLS
SLGGGGGLSG-------SMGGTATIGHVRNSSDHHFSQT-----LGSASPGT-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRDSQ YS--AS-IEENILSSELLRF---QV
TDLDEEYTDNWRAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGI-SSK
KLVDYILGTYQAIDEDTNKAASNV-----KYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPDFNDNCP-TAVLEKDAVCS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGICGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGH----PIEAQQT-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHFVR--TA------AVLFILLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTFL GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YS--AS-IEENALHSNLAQI---RV
IDLDEEYSANWIAVIFFISGNEGGWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEDMK
NLQLSIGVRNKAEFHHSV-MSQYKLTATAISVTVLNVIEGAVFRPGSKTYVVTSN-----
MGQNYKVGDFIATDLDTGVASTT---V--RYVMGNNPANLLDIDSRTGIITLRNAVTMEQ
YKMLGGKYQGTILS--IDD---TL-QRTCTGTININLDGSGWKED---------------
-----------------------------------------KSNQ--G------------
-----------------------------------------------------TTTEDSG
NDGGGSATGGATGGDTGGDTGGD-------------TS--TNTADK-TSTDYGGG-----
----------------TNTDS------NTYDQTGGGYQRNPLDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PR--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPPPIS-----GP-TVCVPPVL----PS-------
------------N-------------------GNLIECIDTSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTEGVKTPGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDVDDSFLD
T-----LGPKFKKLADISLGKEA-ETYPDPDP---SWPPESTEPICPQQGT--------E
PV------------------------------------------------IGG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PSVHVHDNRHAANVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTM-PDPRESSNVVVT
--ERVIRPVSGMMGN-LSIHPELSNAQNVIVTERVVSG-SGISGISGPAGIS--------
--------GGSGLVG------------------------------SAA--GVSGSGIGQS
SLGGGGGLGS-------SMGGTATIGHMRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWFLYRTAAV------LLILGVVVVV--E
IN--SE-FRVQVRDY-NSKNGTVK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAKDQ--EITYRISGVGIDQPPYGVFIVNPKTGEINITSI-VDREITPYFIIY
CRALNK--QGQDMERILELRVRV LDINDNPPVFSMTEF VGSIEENSFANTLVMVINATDA
DEPNNLNSKIAFKIVSQEPADSPMFLMNRYTGEIRTMNAFLDRE----KYATYNLVIRGS
DRDGAADGL-SAQSDCK IAIL-DVNDNIPTLELPT YS--IS-IQENMISQEVTRI---RV
IDYDEEGTDNWRAVFFFVSGNEGGWFNIITDETSNEGIFQ-IV-----------------
---------------------------------------------------KPLDYEMIQ
NLQLSIAVKNVAEFHHSI-ISQYKMQATIISVTIENMVEGSVFAPASKTFIITKN-----
MGKNDVIGSMIATDLDTQGPSKT-----VRYIMGMNPGDFLAINERSGQLIMKSEMTRDL
YIRLGGQYQGTILS--IDD---NL-QRTCTGTIILDLSSFEYLVH---------------
-----------------------------------------ETST--G------------
-----------------------------------------------------PN-----
T--GGTGGSSTSGGDEKEGTGPG---------------------TD-G-DEYETTSSGVY
-----------------SDPS-----TVGREVPGLGLDNFPGDNVHLGPAGIGLLVMGAL
----VLL--LVPLLLT--------------------VCGCGGP---SG--VGGGFEPVPE
CS-------EGAIQT---W-ALEEPQPITNI----------CIPVMPVTVPPDG------
-----------RG------------------HTDSADCINTARVY--------TNEYEER
EMTDLGEIGMGTS--GFEVSNGTKTCAVP------------------------EVCN-GY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
FAYADEDESRPSNDCL---LIYDIEG-V--------GSSAGSIGCCSFIG-EDLDDSFLD
N-----LGPKFKKLADISLGKEI-DSYPEVDH---TWPPESTEPSCPPQGI--------D
VS------------------------------------------------VVG---HPPM
SPH----------FG--TT-IVSESTY-PSGPSVQQSVPI-PDPLGY-GNVTVTESYTTT
-G--SLQ---PPVHIHDPRHGSNVVVTERVVGPISGSD-LQGML------DLTDFREGS-
NVVVT--------------------------ERVIAPNSRLPTSLSI-PDPRDSSNVVVT
--ERVIRPSSGLMGN-LSIHPDLSNAHNVVVTERVVSG-TGVTGISGGGGGGG-------
--------IVGTNVSRGAISMSGAGVSMSGGG----------MALSGS--GLSGGSIEMS
SLGAGGGGLGSIGLSSGGISGSSTLGHVRNS--ELFNQT-----IGSASPST-TRSRITK
YSTIQYSK-----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFL------
-----------VRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMERSS YD--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTGREES----------T-------------SSTDYETSTIYTQ
SA------------------G-----S--TSYENGGHAPLFADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--VV------AMLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYALAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--IE-IQENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSIGVRNKAEFHHSI-MSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGSNDKVGDFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTKEQ
YNMLGGKYQGTILS--IDD---NL-QRTCTGTININIQSFGNDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TEPNTKI
T--------------TNTGRQES----------T-------------SSTNYDTSTTSTD
SS------------------Q-----VYSSEPGNGAKDL-LSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----IT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PV------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVLHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHVHDNRPASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGS----------GALSGA--GISGGGIGLS
S-----------------LGGTASIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MAQSPGGL---------CVLLLLLICF--N
VG---SGLHLQVLNT-RNGNNLLPK-HP-----HLARQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEEGGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALNE--RGVDIEKPLDLRIKVLDINDNEPVFTQDVFFGSVEELSVANTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKMLE--GI-VEENQVNVEVIRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIIVTNKAAFHKSI-RSKYKPTSIPIK VKVKNVKEGIHFKSNVITIYASE--SMER
SSKGQVIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKIPDFES
RYVQNGTYTIKILA--ISE--DDL-RKTITGTIRIAVEDTNDNCP-TLTEPTQTVCN---
G-AQYVNVTAEDLDGYPNSGPFRFSVIDKPPGMA-EKWKIVRQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------HRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQRDGLAGRNG
VG-----GMA-KEAA-VKE---------SSSGSFAKEQREMSELD--GRWEEHRSLLSVR
ATQ--ATGTTGAI-ISKETMKNTRA----T-----GASRD---------VA---------
-G----AQ-------------------TAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHIAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDHFLD
D-----LGLKFKTLAEVCLGQKI---DMEIEQR--QKPATE----------AGM-NTASR
SLYEQTMVNS-------------------ENT-S--SGSSFP-----------------V
PKS--LQE---TNAEKVTQGIVTERSV-SSRQAQKVATPL-PDPVASGNM-MATEASYAT
-GSTMP----PSTVNLGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGLNPLEGTQHLQDAHYVMVR
ERESFLAPSSGVQPT-LAMPNL-AVGQNVTVTERVL------------------------
-------APASTLQSSYLI---PTENSMRVRN-----T-----MVSGA--GVPGPLPDF-
--------------------GLKESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGI-KGS
SLLN YVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDMKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTARQVL
SPGFYEIPVLVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRF------LQSR----RCG--GGTAEGGGSV
LGR----YALQAT------------------RALLHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------VAGAAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWLVFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESSQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGI-KGS
SLM NYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTARQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAP-------MT-------
-------------------------------ASNTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAGLMAAG----AA-----------------GA
A--G-VAGRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMTGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWSFFR--TA------AVLFLFLVVV--E
VN--CE-FRVQVRDY-NTKNGTIK-WNS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--EVTYRISGVGIDQPPYGIFIVNQKTGEINITSI-VDREATPVFIIY
CRALNS--LGQDLEDLLELRVRV LDINDNPPVFAMST FQAQVEENSNANTLVTRINATDA
DEPNNLNSLIAFKITSQQPSDSPMFIINRKTGEIRTMNNFLDRE----QYSHYSLVVRGS
DRDGGADGI-SAECECNIR IL-DVNDNIPYLELSKDT--IS-IDENALYSNLLQI---RV
IDLDEEFSANWMGVIFFISGNEGNWFEIEMNERTNMAILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSIGVRNKAEFHQSI-MSQYKLTATAVSVTVKNVREGPVFRPGSKTYVVTGR-----
MGINDRVGEFSAIDLDTNQISTT---ARYRYVMGSNPGDLLAVDSRTGVLTLKNRLTWEQ
VKMLGGKYQGIILS--IDD---DL-QRTCTGTINIDLQNWD--DR---------------
-----------------------------------------DING--G------------
-----------------------------------------------------STDSSTG
GGTGG-STGGSTGGSTGGGTGTS-------------------------------------
-----------------------------STNDNGNGGDRLDDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---PG--VGAGFEPVPE
CS-------DGAMHP---W-AVEGPQPQPTN-----LS---IIPQFP----ST-------
------------N-------------------NRLLTGLTLSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFEVTDGVKMPGMP------------------------EICQ-DY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-EAYPDPDP---SWPPQNIEPVCLPQDT--------E
PI------------------------------------------------ASG---HPPF
SPH----------VS--T-KVISESVY-PSGPGVQHPKPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PAVHVHDNRHASNVVVTERVLGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNPTESSNVVVT
--ERVIQPASGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGTAG---IS--------
--------GGGGIGS---------------------------------------------
FGAGAGGLSS-------SMGGTATIGHMRSSSDHHFTQT-----LGAASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----RLWIIFLVVL--E
VN--SE-FIVEVKEL-DVEKGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--KITYRISGVGIDRPPYGVFAINPQTGEINITSV-VDREITPLFLIY
CRAL--NARGEDLERPLELRVKV MDINDNPPVFTQNV YTGSIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----EHSMYNLLVRGS
DRDGAADGL-SSECACRIQV L-DVNDNFPTLERTS YS--AS-IEENCLSSELMRL---KA
TDLDEEGTDNWLAKYLILSGNDGNWFEIQTDPRTNEGILR-VVKC-PMCRYKLETKLQTN
KIQMNIDAIKHIAGRTVCLDNV CVIPLGFGVWNDVTNDLYSSHP----QNAQM LDYEQMP
NIHLSIGVKNQAEFHHSV-ASRFRMHSTPVRIQV INVREGPTFDPNS MTFSVQEGV-RGD
SLTNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--VDD---GS-GKTATGTICIEVPDVNDYCP-VIVAESNAICT---
A-SPSILISARDINHHSYGSPFTFCVVDQPPGTA-NLWDIKSVNA--TSAL--LTAGQPL
SAGAYQIPILVKDSFNRACELPQTVKIE--ACDCDISQTCLHSSTPGIYTGDG------S
------------------------------------------------------------
---------------SVTSDIYGP----------VPGDRIEGSNVGLGPAGIGMIALGLL
----LLL--LSPLLLL--------------------FC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVIQS---W-RIEGAHPEDRD------VSNICVPI--T-----A------
--------------------------------SNTQDRMDSSDIY--------TNTYAAG
GTV--EGGV---S--GMELNTGLG--TTG-L-AAG------------------------A
G--GTLRRRGS-MLGPPREQADM-G-------LN-LAFLDSYFS----------E---KA
YVYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDEDYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAM-PEPMIH-GDIVVTETYTTT
--DQCMQ---PTTIVFDPQLAPNVVVTETVMTPVYDVQ---GN-----------------
------------------------------------------------------------
----------------LCVPAELANAQNVIYTERVVSS-PGVPDMRSGSMTDG-------
--------CMGPVMSGS---------------------------------ILVGPEIQVT
Q---------MV-----------------NPPDIHISRT-----IGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MARLFP---RAL-----APLALLMVVL--L
VH--GE-LHVKPGGQ-HREDGTALQ-VA------KRRYKREWVKFAKPCREREDNSRRNP
IAKITSDFQKTQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLILTVKI LDVNDNPPVFSQTVF RGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDRE----QISSYHLVVSGA
DNDGTG--L-STQCECSIK IK-DVNDNFPLLRDSQ YS--AR-IEENTLNAELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQVQ
NMQFSIAVRNKAEFHQSV-ISQYRVQPTPVTIQ VIDVREGISFRPPSRTFTVQRGV-ST N
KLVGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAQIKFVKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVYVEVPSFNENCP-SVVLEKRDICT---
S-SPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLP-VMWTIKTLNA--TSAL--LQAQQQV
SPGVYNVPVIVKDNQDGQCDTPESLTLT--VCQCDDRNMCRAPVPSREP-----------
------------------------------------------------------------
-----------------------------IT--------YEESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGS-GPIGG-AATGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PVT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V--VEGA---S--GMEMTTKLGGATGAA--------------------GALGPCSLGH
S--GTMRTRHS-TGGTLKDYA-A-P-------IN-MTFLGSYFS----------Q---KS
LAYAEEEDEREVNDCL---LIYDDEG-G----DAAPHSP--SLSSCSFFA-DDLDDNFLD
S-----LGPKFKKLAEICLGIDD-EAKQAKPG---PKDSGSGADTCAR----SMEVPQAG
-----------------------------------------------------SNRYQTL
PGSLEVTQTGSKICHTLSGNQETSVLS-TSGS-VHPAVAI-PDPLQL-GNYLLTETYST-
SGS-FVQ---PTTVTFDPHVTQNVTVTERVICPLPSAS---SSIVAPT------ELRGSY
SMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGGRCALLL----VVQLLAVVCL--D
FG---NGLHLEVFST-RSEGKPFSK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEQGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSI-LDREETPYFLLT
GYALDS--RGKNLEKPLDLRIKVLDINDNEPVFTQEVFVGSIEELSAANRLVMKITATDA
DDPETLNSKVSYRIVSQEPTNSPVFYLNKDTGEIYTTSLTLDRE----EYSSYSLTVEAR
DGNGQITDKPVQQAQVQIR IL-DVNDNIPVVENKM YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYEEMK
KLDLSILVTNKAAFHKSI-LSKYKATPIPITV KVKNVVEGIHFKSSVVSFRASE--AMDR
S SLSRSIGKFQVFDEDTGQAA-KV-----TYAKVQDSDNWVSVDSVTSEIKLVKIPDFES
RYVQNGTYTVKVVA--ISK--DHP-QKTITGTIVITVEDVNDNCP-VLVDSVRSVCE---
D-EPYVNVTAEDLDGPQNSGPFSFSIIDQPPGTA-QKWKITHQES--TSVL---LQQRER
KLGRSEIPFLISDSQGFSCPERQVLQLT--VCECLKGGGCVAA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGGDAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVT-----DHAESPAVRGS
VG-----GAMLKEGM-GKSGSSAMKG--GSSASVTKGQRELSEVD--GGWEEHRNLLTSG
ATH--HVRTAGTIAANETI--RTRP----T-----GASRD---------MS---------
-G----ARG--------------------AVAMN-EEFLRSYFT----------E---KA
ASYTGEDDLHMAKDCL---LVYSQED-T--------DSLRGSVGCCSFIE-GELDDLLLD
D-----LGLKFKTLAEVCLGRKI-DMDVDIEQR--QKPVRE----------ASL-SAAPG
SHYEQVVTKS-------------------ESTYS--SNTGFP-----------------A
PKP--PHK---AHTEKVTQEIVTESSV-SSRQSQKVVPP--PDPVASGNI-IVTETSYAK
-GSAVP----PSTVLLAPRQPQSLIVTERVYAPTSTLV-------------DQH-YANEE
NVLVT--------------------------ERVIQPNGGIPKPLEVTQHLKDAQYVMVR
ERESILAPSPGMQPT-LAVPSVAAGGQNVTVTERILTP-GVAAHTFNPSTREAEKQRKKQ
RKKQRILTPASTLQSSYQI---PSGTSIQARK-----T-----VLSSV--GSMGPLPNL-
--------------------DLEESGHRNS-------------------IITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARSPSGRCTLLL----LLQLLAVVCL--D
FG---DGLHLEVFST-RGEDRLFTK-RT-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGIKITYKYTGKGITEPPFGIFVFDRNTGDLNITSI-LDREETPFFLLT
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDA
DDPQTLNSKISYRIVSQEPANTPVFYLNKDTGEIYTTSFALDRE----EHSSYSLTVEAR
DGNGQITDKPVQQAQVQIR IL-DVNDNIPVVEYGT YE--GV-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KELDYEEMK
KLDLSILVTNKAAFHKSV-VSKYKATPIPITVK VKNVVEGIHFKSSTVTFRASE--AMDR
S SLSRSIGKFQVFDEDTGKAA-DV-----TYVKVQDTDNWVSVDSETSEIKLVKIPDFES
RHVQNGTYTVKVVA--ISK--GHP-QKTVTGTILINVEDVNDNCP-VLVDSVRSVCA---
D-APYVNVTAEDLDGPRNSGPFTFSIIDQPPGTA-QKWKITHQES--TSVL---LQPSER
KLGRSEIPFLISDSQGFSCLERQVLQLT--VCECLEGGGCVAA-----------------
------------------------------------------------------------
---------------------------------------LYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVT-----DHVENSGVRGG
GG-----GGG------GGVGGVKLKEGVSSSASITKGQHELIEVD--GRWEEHRSLLTSG
LTH--HVATAGSIAANDTTIRTTRA----T-----GASRD---------MS---------
-G----ARG--------------------AVAMN-EELLRSYFT----------E---KA
ASYAGEDDFHLAKDCL---LVYSQED-T--------DSLRGSVGCCSFIE-GELDDLFLD
D-----LGPKFKTLAEVCLGRKI-DMDVDIEQR--QKPVRE----------TSV-NAAPG
SHYTQVTASS-------------------ESTYS--SNSGFQ-----------------A
PKP--LHG---AHTEKVTQEVVTESSV-SSRQSQKVVPP--PNPVASGNI-IVTETSYAA
-GSAVP----PSTVILAPRQPQSLIVTERVYAPASTLV-------------DQH-YANEE
NVLVT--------------------------ERVIQPNGGIPKPLEVTQHLNDAQYVMVR
ERESILAPSSGVQPT-LAMPSVAAGGQNVTVTERVL------------------------
-------TPASTLQSSYQI---PSEASIKARK-----T-----VLSSV--GGMGPLPNL-
--------------------DLEESGPPNS-------------------TVTTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILTVVL--E
VN--SE-FVVEVKEL-DAENGTAK-WQT------VRRQKREWVKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIVSQEPAGSPMFIMNRYTGEVRTTSNLLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRF---QT
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQVVNVREGPAFHPNSMTFSVREGL-KGN
SLLNFVLGTYTAIDLDTGNPATNV-----RYIIGHDAGNWLKIDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---VS-VKTATGTICIEVPDVNDYCP-VIVAERETICI---
A-SPSILISAAGVNSHSYGSPFTFCVVNEPPGTA-DIWDIRSVNA--TSAI--LKAEQTL
YSGYYEIPVLVKDSFNRACELPQIIELR--ACDCDINHMCLSSGTTGVSTGDGSSVTS--
------------------------------------------------------------
----------------------VS----------VTDDQTEASNVGMGSTGIGMITMGVL
----LLL--LAPLLLL--------------------LCCCCKRKQPEG--LGTSFAPVPE
GG-------EGVVQS---W-RIEGAHPEDRD------VSNICVPM--T--A---------
--------------------------------SNTQDRMDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELSTGLG--AATGLAAGG------------------------A
A--GTAGRRSS-AVGIQRDYGDT-G-------LN-LAFLDSYFS----------E---KA
YAYAGEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFKTLAEICLDTEI-DPFPS-QQ---SCIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFKEEVAI-PEPVMH-RDIVVTETYTTA
--DPCVQ---PTTIVFDPPLAPNVVVTETVMAPVYEVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVVSS-PGRPDVSSSSVSDG-------
--------CRGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIRISQT------SSTSPVT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
--------------------------------------------------LSLQICL--T
CG---NGLHWKIYNRSA-RNGTLTH-PN-----SLVRQKREWTVPPAFIREEEDNSYRNP
IARIHSDF-EDTGVVVTYTISGQGVTEPPYGLFVINGKTGDLNITGK-VDREKTPVLFLR
GHALDK--TGAKLEEPIDLPVRV LDINDNPPVFSHEV FVGSIEELSETGTIVMRLNATDA
DEPNNLNSKIAFKIISQSPS--SAFNMNKDTGEVRVAAINLDRE----TQSSYSLVVEGK
DRGGAADGN-SATCSLEIKI L-DVNDNLPVLESSA FE--GS-VEENRANVEIMRI---KV
FDKDEEFSDNWLANFSFVSGNEGGYFRIVTDTRTNEGILT-LV-----------------
---------------------------------------------------KELNYEEMK
SLNLGIVVTNKAEFHKSI-KSSYKAQTIPIKINV IDVREGLVFPSGT KIIEASES-----
VRVGQVIGQYQAVDEDTGKAAVRV-----KYIKGRDPANWITINSNTGEIQLAKNLDYES
HYVVNGTYTFTMLG--VTTVLDLP-TKTATGTVVIQVQDENDNCP-VIENPIQTVCS---
D-ANFVDVTAKDIDSYPNSAPYSFSVIDEPEGTA-RKWIVASKNA--TSVR---LVPQNL
KEGSAKVSLLIQDFQGFSCAQPQSLQLF--VCTCTADGACKDR-I---------------
------------------------------------------------------------
---------------------------------------TGTGSVGLGPGAIALIILAFL
----LLL--LIPLLLL--------------------LCPCGSGAK-------KGFAAIPD
CS-------EEMLRK---W-NSEGAAPEEKL------TPSGSVKDAWK---GNSNSSS--
----------RNTNH--------SV-KIPNSASYIRGQN-NMITR--E----EQRHLSHA
DYH--TRTMA---TGGSEGMV---------------------------------------
-A----GEGN--MVVTGG--G---VAMGSAGAMN-EEFLRDYFT----------D---KA
VSFAEEDEAQAARDCL---LVYSQGE-S--------GSPHGSIGCCSFIE-GDLDDHFLD
D-----LGEKFKTLAEICIGRHI-DMKD---------------TSCKNESSFDVN-----
---EQKAFSS-------------------KQVSA--SGGYFS-----------------P
TPS--AQAGGAVVLE--------------------------------------E-TSYSA
-EGHTH----SAASFLDPQFKENIVVTERVLAPASSLR---GMV------EIPS-LPSGN
NMVVT--------------------------ERMVTSEGFEVGTMA-VQDPSDSKYVVVR
ERERVLVPSTE-QSS-LSIPTL-SEGQSMVVNENDLTA-SAGPG----------------
----------------------------RAEQ-----VLITDSLLS----SLEGAPP---
----------------------------------------------AS-STLSKSSRVTK
YSTVQYSRS----------------

------------------------------------------------------------
------------------------------MVNIIF---KPT-----FYYEYLQVVV--E
VN--CT-FWVEVKEQ-NEESGTALQ-KP------LRRYKREWVKFAKPCREREDNSKRNP
IAVITSDFQKTQ--RITYQISGVGIDQPPYGIFIVNPTTGEINITAI-VDREETPKFLIT
CRAVDE--RGRDVEKPLILTVKI LDVNDNPPVFSQSIFY GEIEENSAANTLVMVLNATDA
DEPNHINSKIAYKIISQEPAGQPMFLLNRHTGEVHSMTNTLDRE----KYSKYSLLVSGA
DLDGAG--Q-ATECGCQIT IK-DVNDNFPYFKESQ YS--IK-IEENMLSSEVIRF---QV
IDLDEEFTDNWFAEYFFTSGNEGNWFVIETDTKTNEGILK-VV-----------------
---------------------------------------------------KALDFEQFQ
NMQLVLAVKNKAPFHHSV-ISLDQIQSIPIKVTVINVKEGIAFHPTSKTFIVKKGI-SYK
KLISYVLGTYPAIDEDTGKPASFI-R--NRYAMGRNDGGFLVIDSKTAQIKFVKNIDRDS
TFIVNKTLTAEILA--IDD---ST-GKTSTGTVIVKVPDFDENCP-KISADKETVCR---
T-SASVIVTAKPLQNQPYTQPFKFSLVEQPVGTP-AIWSITAIND--TSAI--LRAQKTL
STGTYPLSLTVTDRQGMSCEITETLELR--ACDCDENQKCVEKVPFPKP-----------
------------------------------------------------------------
-----------------------------GD----TNRQRGKPSVSLGPAGIGLLLLGLL
----MLL--LAPLLLL--------------------FCDCGA-GGLGG--VGSGFVPVPD
GF-------EGTIHQ---W-GIEGAQPQDKE------ITNICVP-PIT------------
-------------------------------ANGTEF-MENSEVC--------TNAYATE
T-I--TEGT---C--GIELMTRLRAASGSGGTAGL--------------------GGTGY
S--GTMRTRHS-TGGTIRECAEG-P-------IS-MTFLDTYFS----------Q---KA
VACAEEDDDQLVSDCL---LVYDDE--G----VEPPSSP---VGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISMGIDN-ETKPSEAP---GKTTT--TETLGSVS-------ACA
TSTNVTCQPT------------------------------------TNITC---------
----------QPATGTTFYSNGTSTLS-ASGSVLVPAIPI-SDPLLQ-GNFLMGESYTA-
SSS-FLQ---PSNVVFDSQLTENMIVTERVICPISSVSGIQGNLHGPM------QLAGSC
NMTCT--------------------------RD-----------SC--------------
--S---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
--------------------------------------VYNMRGGRLLISEIFKICF--D
F--G-NGLHFEVLHS-RNESKLLPK-HI-----HPVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKNLKITYKYTGKGITEPPFGVFVFNKDTGELNVTTI-LDREETPFFLLT
GYALDE--RGKNLEKPIELRIKVLDINDNEPVFTQDVFVGSVEELSAANTLVMKITATDA
DEPNTLNSKISYRIVSQEPASSPVFYLNKDTGEIYTTSITLDRE----EYSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVDRNV YE--GS-VEENQANVEVLRI---KV
SDADEVGSDNWLANFTFASGNEGGYFRIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYETMK
NLDLSIIVTNKAAFHKSI-KDKYKPTSIPIK VKVKNVKEGIYFKSSTIQFHTSE--SMEK
LSQGQILGKFQAFDEDTGKVT-NV-----KYAKFEDIDNWISVNSATSEIKLVKIPDYES
RYVQNGTYTAKILA--ITE--EYP-RKTITGTVVINVEDINDNCP-TLVDPVQTVCD---
Y-VPFVNVTAQDLDGPQNSWPFGFSVIDKPAGMA-ERWKIVRRED--TSVL---LQQTKR
QHGTSEIRFRIADSQGFSCPEEQILKLT--VCNCVEGSGCVNM-----------------
------------------------------------------------------------
---------------------------------------WADSSVGLGPAAIALIILALL
----LLL--LIPLLLL--------------------VCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VVPLLGA-----DLRDGAAVGAA
VGAGVGGGVTAKEAI-VKG---------SSSASFTKGQQEMSEAE--GRWEEYRSLVSGG
ATQ--ATGTTGAM-VTSDTFRATRA----T-----GAARE---------VA---------
-G----AR-------------------AGAVAVN-EEFLRSYFT----------E---KA
ASYTEEDDIHTAKDCL---LVYSQEE-T--------ESLRGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGRKI-EMDAETQKR--AKPARE----------ADG-KAVSR
SLYEQTRLNS-------------------ENAYA--SGGSFQ-----------------G
PKP--LHE---ADTEKVTQEIVNEKSVISTRQAQKVTAPL-PDTLASGSV-VVTETSYAT
-GATGP----PSTVVLGPQQSQGLIVTERVYAPASTLG-------------NQQ-YASEG
HVVVT--------------------------ERVIQPHGGMSIPLEDTPPLPDAHYVMVQ
ERERFLTPSSSLQPL-LAAPSV-ALGQNVTVTETVL------------------------
-------TPASALQSNYQI---PAETSVMARK-----T-----VASAA--GVPGSLPDS-
--------------------GLEESSHSNY-------------------TVTTSSTRVSK
QSTVQQSF-----------------

------------------------------------------------------------
------------------------------MNWHFFR--TA------AVLFICLVVL--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLERPLELRVRV LDINDNPPVFSMST FIGEVEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEVRTMNNFIDRE----KYSQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEQSS YS--VN-IEENTLSSNLLQI---RV
IDLDEEFSANWMAVIFFITGNEGNWFDIEMNERTNVGTLK-VI-----------------
---------------------------------------------------KPLDYEEVK
NLQLNLGVRNKAEFHQSI-KSQYKLIGSAISVTV LNVIEGSVFRPGSKT YVVTSN-----
MGQNYKVGDFVATDLDTGLPSTT---V--RYVMGNNPTDLLAVDSRTGVITLRNKVTKEQ
YQTLNGKYQGTILS--IDD---SL-QRTCTGTININLDGSGWEDR---------------
-----------------------------------------EQST--T------------
-----------------------------------------------------SGEIING
GSTST---------STSDVTSSD-G-----------SNINTNAGNA--------------
--------------------------GSSATSTFDGDGTDLADNVHFGPAGIGLLILGFL
----ILG--LVPFLLL--------------------CCDYGGA---AG--AGAGFEPVPE
CS-------DGAIHP---W-AVEEP--PPTG-----LT-PVCVPA-G----PA-------
------------N-------------------ANIIECVDNTGVY--------TNEYSGR
--Q-DLGGGERTT--GFEMTEEVTTSRAP------------------------EICQ-DY
S--GTMRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEA-EPYPEPDP---SWPAESTEPICPPQGT--------E
PI------------------------------------------------GSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPVPI-PDPLGY-GNVTVTESYTTS
-G--TLR---PSVHVHDNRQASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTTLTI-PDPRESSNVVVT
--ERVIRPTSGVMGS-LSMHPELSNTHNVIVTERVVSG-SGITGISGSGDSS--------
--------GT---GSSGL-----IG--------------------SAA--GVSGGGIGLS
-----------------SMGGTATIGHLRGSSDHHFSST-----LGSASPTT-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------ALLLTSL------
-----------VRDH-NAKNGTIR-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDRE------IY
CRALNA--QGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGL-YAESECSITIL-DVNDNIPYLEQSSNK--CR-NS----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
----GGQ--VVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHN-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
XAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPDP---SWPPQSTEPMCPQS-T--------E
PL------------------------------------------------GSG---HPPI
SPH----------FG--RTTVISENVY-PSGPGVQHPMPI-PDPLGY-GNVTVRESYATS
-G--TLK---PSVHFHDNQQTSNVVVTERVVGPVPDAD-LHGML------EIPDLRGGA-
NVIVT--------------------------ERVIAPGSSLPTSLAI-PNPRETSNVVVT
--ERVIRPTSGMIGN-LSMPPELSSAHNVTVTERVVSG-AGMSGIAGTAALG--------
--------GVGGVGSSGI-----VSTTMGAGG----------MGLSGA--GACATTPG--
---------L--------------------------------------------------
-------------------------

------------------------------------------------------------
--------------------------------RKPPRECGLLLL---MSVISLQICF--N
FG---DGLHLEIFNT-RNENKLLPK-HT-----YLVRQKRAWITAPVALREGEDLSKKNP
IAQIHSDTAEERGIKVTYRYTGKGITEPPFGVFVFNKDTGDLNVTSI-LDREETPFFLLV
GYALDV--NGNNVEKPLELRIKV LDINDNEPVFTQDV FVGSVEELCARGTLVMKINATDA
DEPNTLNSKISYRIVSQEPASLPVFYLNKDTGEIYT-SITLDRE----EHSSYSLTVEAR
DGNGQITSRPAKQAQVQIQI L-DVNDNIPRVENEV YE--GS-VQENQANVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAVTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
TLDFSVIVTNKAAFHKSV-MNKYKPTPVPVKVTV KNVQEGIYFKSST ISVQVSE--GMDQ
SSKGRIIGKFQAFDEDTGQLA-HV-----KYIKYEDIDDWISIDSVTSEIKLVKIPDFES
RYVQNGTYTAKILA--ITE--DYP-RKTITGTIRVMVEDINDNCP-RLVNPVQSVCD---
E-TPYVNVTAEDLDGHQNSEPFSFSVIDEPPGMA-EKWKIVQRKG--TSVL---LQQREQ
KLGQSEIKFLIKDTKGFSCPEKQTLQLT--VCKCLDGSGCVGG-----------------
------------------------------------------------------------
---------------------------------------LHDSYIGLGPAAVAIMILALL
----LLL--LVPLLLL--------------------VCHCGEGTK--GF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKI------VPSLVVA-----DHGACPGVGSG
TG-----ATLTKDIT-VKG---------SSSASISRGLHEMSEVD--ARWEEHRSLLSGG
ATQ--VTRLPGAI-LGTETIRTTRA----T-----EVTRD---------TA---------
-G----AQ-------------------AAATAVT-EEFLRNYFT----------E---KA
ASFTEDSDSHTAKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GEPDDRFLD
D-----LGFKFKTLAEVCTGQKI-DMGMEIEER--QKPVTE----------TSK-STASR
SHHEQTMVNA-------------------ENTYS--SGSSFQ-----------------V
SEP--LHE---AKAEKVTQELVAERSI-SSRQGQTVPTPL-PDPLVPSNI-VVTETSYAT
-GSTIQ----PSTAILGSRQPQGLIVTERVYAPASTLV-------------DQH-FGNES
DVLVT--------------------------ERVIQPNEGVLNPLEVPQHLPNAHYVMVR
ERERVLAPSSSVQPP-LAMPDI-AVGQNVTVTERVL------------------------
-------TPASTLQSSNQV---PAETSSMARK-----T-----MVSGA--SVTGPVPNF-
--------------------GLEAPAHSNS-------------------TITTSSTRVTK
QSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCELNQ--KITYRISGVGIDRPPYGIFTINPRTGEINITSV-VDREITPLFLIY
CQAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLSATDA
DEENHLNSKIAYKIVSQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSTYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
TIQLGIGVKNQADFHYSV-ASQFRMHSTPVRIQVINVREGPTFHPSSMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPAKNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKRS
KYIINGIYTAEILA--IDD---DS-GKTATGTICIEVPDVNDYCP-DIIPERRAICI---
D-SPSVLISV---NEHSYGAPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQFL
SPEFYQIPILVKDSYNRACESAQIVQLY--ACDCDDNHMCLDSSAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTHGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-GIEGAHPEDRD------VSNICAPMTAS------------
---------------------------------NTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGLG--TAAGLVAG------------------------GA
A--GATRKRSF-AVGTLRDHADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGVT-PSEAEFQEEMAA-SEPVIQ-GDIIVAETYGAA
--DQCVQ---PTTIIFDPQLAPNVVVTETLMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CMGPVMTGS---------------------------------VLVGPEIQVM
Q---------MM-----------------S-PDIPISQT-----IGSTSPMT-PRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MWRSLQRP-------YGHNLIIVLICF--H
LG---NGLHLEVLYT-SNENDQISQ-QGYLFQQKLFRQKREWITAPVALREGEDLSKKNP
IARIHSDLAEERHIKVTYRFSGQGITEPPFGIFVFDKNTGELNVTKI-LDREEVPMFVLT
AYALDE--RGNNLERPLELRLKV LDINDNEPVFTQDVF VGSVEELSPANTLVMKISATDA
DEEGHINSKISYKIVSQEPPQPFVFFLDKDKGEILTTAFVLDRE----KHSHYSLIVAAT
DGNGEKTDKPVNQAKVQIN IL-DVNDNIPVPEFEM YE--GS-IEENQANVEVMRI---KV
TDLDEIGSDNWLANFTFLSGNEGGYFHVETDVQTNEGIVT-LI-----------------
---------------------------------------------------KEVNYEVLK
TLDLKILVTNK APFHKSI-RNKIEAKSIPIKIKVKNVIEGVHFRQQKIVIQTSE--HMER
SEIGKIIGKYQAYDEDTGQIA-QV-----TYAKGEDIDNWITIDSVTSEIRLAKIPDYES
KYVINGTYFATILA--ITK--DFP-RQTATGTIEIVVKDFNDNCP-ELINPVQTICD---
D-THYVNVTAKDLDGYPYSSPFSFAVIDQPPGMA-ENWYFGHQEA--TSAW---LIPKEL
KVGRSEIHLSVSDNQGLNCPEKQILTLT--VCSCVSGSGCILP-----------------
------------------------------------------------------------
---------------------------------------LEDSYVGLGSGAIGLMIFALL
----LLL--LIPLLLL--------------------LCHCGGAGG-----GAKGFTAIPG
-T-------VEMLHP---W-NNEGAPPEDKV------VTSLITT-----DLAGNSGASAG
GGSR-TGVLISSETT---------------RRESSSGHRTMTMVD--GGWEEHRSLLTGG
IKR--IGGVTGARR-D--------------------------------------VTT--V
GAAAAMSGAT--MMGASGAMGTI-GSRTNTAALN-EEFMRSYFI----------E---KA
ASYADNDEIQTGKDCL---LVYSQEE-T--------QSPRDSIGCCSFIE-AEWDDHYLD
D-----LGIKFKTLAEICTGQKI-ETETESGLK--YELPTE----------ASM-NAVSH
SVYEQNTLQA-------------------EKSHSS-SSISFS-----------------A
PKP--INE---SISETLTQELVSERTL-SSRQGLKVARTL-PDPLPVGNI-VITERSYGT
-GSTLP----PSTLILSSKQPQSLMVTERVYAPASSLV---DTQF------VQH-HAGEG
SVVVQ--------------------------EHMIQPNGGLSNSLGSTQDLSDSHYVVVR
ERERFLAPSASLQPI-QTIPSL-AVGQNVTVTERVL------------------------
-------TPASNLQAS---------------K-----T-----VVSGS--GTLAPLQNL-
--------------------DFQESVPSNS-------------------SVTISSSRVTK
HSTVQQSYS----------------

------------------------------------------------------------
------------------------------MARSPGGRCALLL----VVQLLAMVCL--D
FG---NGLHLEVFSA-RREGKPFPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGLKIIYKYTGKGITEPPFGIFVFDRNTGELNITSI-LDREETPFFLLT
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDA
DDPETLNAKVSYRIVPQEPANSHVFYLNKDTGEIYTTSFTLDRE----EHSSYSFTVEAR
DGNGQITDKPVQQAQVQIR IL-DVNDNIPVVENEM YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KELDYEEMK
KLDLSILVTNKAAFHKSI-LSKYKPTPIPI TVKVKNVVEGIHFKSSVVSVRASE--AMDR
S SLSKSIGKFQVFDEDTGQAA-KV-----TYVKVQDTDNWVSVDSVTSEIKLVKIPDFES
RYVQNGTYTAKVVA--ISK--DHP-QKTITGTIVITVEDINDNCP-VLVDSVRSVCE---
D-EPYVNVTAEDLDGPQNSGPFSFSIIDQPPGTA-QKWKITHQES--TSVL---LQQSER
KRGRSEIPFLISDSQGFSCPERQVLQLT--VCECLKGGGCVAA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGGGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVA-----DHAESSAGRGG
VG-----GAMLKEGM--------MKG--SSSASVTKGQHELSEVD--GRWEEHRSLLTAG
ATH--HVRTAGTIAVNEAV--RTRA----T-----GSSRD---------MS---------
-G----ARG--------------------AVAMN-EEFLRSYFT----------E---KA
ASYNGEDDLHMAKDCL---LVYSQED-T--------ASLRGSVGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGRKI-DMDVDIEQR--QKPVRE----------ASM-SAAPG
SHYEQVVTNS-------------------ESAYS--STTGFP-----------------A
PKP--LHE---VHTEKVTQEIVTESSV-SSRQSQKVVPP--PDPVASGNI-IVTETSYAK
-GSAVP----PSTVLLAPRQPQSLIVTERVYAPASTLV-------------DQH-YANEE
NVLVT--------------------------ERVIQPNGGIPKPLEVTQHLKDAQYVMVR
ERESILAPSSGVQPT-LAMPSVAAGGQNVTVTERIL------------------------
-------TPASTLQSSYQI---PSETSIKARK-----T-----VLSSV--GSMGPLPNL-
--------------------DLEESDHPNS-------------------TITTSSTRVTK
HSTMQHSYS----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILFMVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILK-LV-----------------
---------------------------------------------------KMLDYEQEP
NIYLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVVNVQEGPTFSPSSMTFTLRGGM-RGD
SLMNYVLGTYTAIDMDTGNPATNV-----RYVIGHDAGSWLKVDSRTGEIQFSREFDMKS
KYITDGMYAAQILA--IDD---GS-GRTATGTICIEIPDANDYCP-VIYAESRSVCT---
H-ASSVRIYV---NDHSFGSPFTFCVVDESPDIA-NIWDIRSING--TSAI--LMTEQTL
SPGPYQIPILVKDSHNRACELPQTVLLD--ACFCDDHHVCLHSSTTGIYTGDT------T
------------------------------------------------------------
---------------WVTDDMYGT----------VTDDGVRQSNVGLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TATGMVAAG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-T--------GSPVGSIGCCSWIV-DDLDESYIE
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAAASEPMIH-GDIIVTETYTTS
--DPCVQ---PTTIVFDSQIPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGIPDMGNSNMSDA-------
--------CIGPVMSGG---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PDIHISQT-----TGSTSPMT-SQHRVTR
YSNIHYSRQ----------------

------------------------------------------------------------
------------------------------------------------------------
-----------VRDH-NAKNGTIR-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDRE------IY
CRALNA--QGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGEDGL-YAESECSIX IL-DVNDNIPYLEQSS YD--IS-IEENTLHSQLVQI---RV
IDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAMK
NLQLSIGVRNVAEFHQSI-ISQYRLTATMVTVTVLNVVKGCVFQPGSKTFVVDSR-----
MEANHTVGEFLATDCETGLATNKFKNVRYRYVMGNNPENLLAIDS--GIITLRNRVTMEQ
YQRLNKRYEGTVLS--IHD---SL-QRTCTGTIIMVLCGF-WTTT---------------
-----------------------------------------EHPT--T------------
------------------------------------------------------------
------------------------------------------------------------
----STETP---------------------------SITPKVNNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-TVEGPQPEPHN-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDSVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRNG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGHPSKDYL---LIYDIED-L--------ECSCDRKSD----------P----
----------------TNLGHD---RQPEHAP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-----------------------------------------------------------M
KC--EH-LLLKVKEL-DMENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEVSQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAV--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YAASIEENSEANTLVVKLSATDA
DEENHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSTYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPILEKTF YS--AS-IEENCLSSELIRF---QA
IDLDEEGTDNWLAKYVILSGNDGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KVLDYEQVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVKIQ VVNVREGPAFHPNSMTFSVREGM-RGN
SL LNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGNWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GT-GKTATGTICIEVPDVNDYCP-VIVAERETICI---
T-SPSILISATGVTDHSYGAPFTFCVVDQPPGTA-DSWDIRSINA--TSAI--LTAEQVL
YPLDYEIPILVKDSFNRACELPQIVALK--ACDCDSNHVCLYLGTTGIHTGDGSSVTSV-
------------------------------------------------------------
-----------------------S----------VTDDQTGTSNVGLGPTGMGMIALGLL
----LLL--LSPLLLL--------------------MC-CCKRKQPEG--LGTRFAPVPE
GG-------EGVIQS---W-RIEGAHPEDRV------SGPSLTA----------------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLVAGG------------------------A
V--STARKRSS-TLGTQRDYADN-S-------LN-LAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLNTEI-EPFPS-QL---ACIPINT------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMN-LSEAEFQAEMAA-PEPTIH-GDVAVTETYTTA
--DPCVQ---PTAIVFDPQLAPNIVVTETVLAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVLSS-PGMTDISNSSMTDG-------
--------CVGPTMSGG---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDIHLNQT-----IGSTSPMT-SRHRVTQ
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------CNYLFEECTCNL-----TLFKCLQVFV--L
VH--GE-LRIETKDP-HGEEETAVQ-QG------KRRYKREWVKFATPCREREDNSKRNP
IARITSDFQTTQ--KITYRISGVGIDQPPFGIFIVDPNTGEINITAI-VDREETPSFLIT
CRALNV--LGQDVEKPLILTVKI LDVNDNAPVFSQRIF KGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPTGTPMFLISRNTGEVRTLTNALDRE----QFSSYRLVVSGA
DQDGVG--L-SAQCECEIK VK-DVNDNFPVLKYSQ YS--TR-IDENTLSSDLLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGKWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KPLDFEQVQ
SVRFSVAVKNKAAFHQSI-VSQYRVQSTPVTIEITDVREGISFRPTAKTFSVKKGI-SSR
KLINYVVGTYEAIDEDTGKAASSV-----RYVMGRNDGGLLIIDPKTAQIKFVKNIPRDS
TFIVNKTLTAEVLA--IDE---NT-GKTATGTIRVEVPEINENCP-PVILEKDEICT---
S-SPSVVVSARTLERDRYAGPYTFSVEEQPVKLP-VVWRITSLNA--TSAL--VRAQQQI
SPGVYQVPLVVTGNQDRQCESSEMLTLT--VCQCNDRGSCRTSENDPHI-----------
------------------------------------------------------------
-----------------------------E---------PRKQLSRMGPNAIGLLLLGLL
----LLL--LVPLLLL--------------------TCDCQ-RGPAGG--VAGGFIPVPD
GS-------EGTIHQ---W-GIEGAPPEDKE------ITNICVP-PIT------------
-------------------------------TNGAD-IVESSEVC--------THTYTGG
T-V--MEGV---S--GMELAT-----------KGF------------GAATGLGPCPPEH
LGLGTMRTRHS-TGGTLKDYADG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEEGVQEANDCL---LIYDNEG-T----DDAP---GSSLGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGIDE-EAKQAQPP---PQYSGTGADLSGR----PV------
------------------------------------------------------------
----EAQQSGLERYQTVWGSQEAHALS-TYGS-LQPAIPI-PDPLQH-GNYLVTETYSA-
SSS-FVP---PTTAVFDPLLTQNVTVTERVICPHSSIP---GST----------DPRGSC
SMLCS--------------------------ED-----------PC--------------
--SRQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWFLFR---RI-----GILVILMXX-XX-
XX--XX-XXXXVKEL-DSENGTAR-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEAHQ--KITYRISGVGIDRPPFGVFTINPRTGEINITSV-VDREITPMFLIY
CRAL--NSRGEDLERPLELRVKV MDVNDNPPVFTQNV YSASIEEHCATNTLVIKLSATDA
DEENHLNSKIAYKIISQEPAGSPLFILNRYTGEIRTMTNYLDRE----EHSTYNLIVRGS
DRDGAADGL-SSECECRIKII-DVNDNFPILEETSXX--XX-XXXXXXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-XXX
XXXXXXXXXXXXXXXXX-XXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--X-----XX-XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX---
X-XXXXXXSVMITTDNSFGSPFTYCVMDQPPGTA-DLWDIRSINA--TSAI--LTAMQQL
SPGLYQVPILVKDTYDRTCELPQIITLE--ACECDDKHMCSYYSTTGIYPGGS----SIT
------------------------------------------------------------
---------------IVTGNNYGT----------VAGDRIGDGNVGLGPAGMGLIILGVL
----LLL--XXXXXXX--------------------XX-XXXXXXXXX--XXXXXXXXXX
XX----------------------XXXXXXX------XXXXXXXXX--------------
--------XALQQ------------------SPAIHENVFFPEIY--------TNTYAGG
GTV--EGAASGVS--GVELNTGVG--AALSLGAGG------------------------L
A--GAVRRRGS-TMGTLREYTET-G-------VN-MAFLDSYFS----------E---KA
YAYADEDECRPANDCL---LIYDHEG-M--------GSPVGSIGCCSWIV-DDLDDSYLE
T-----LDPKFRTLAEICLDTEI-EPFPSPHQ---AWIPITT------------DLPLLG
PNY---------------------------------------------------------
-----------------I-VNEPSATS-LTEAGFQAEMAM-PDPMIH-GDIIVTESYSTS
--DQCVQ---PTTIIFEPQLVPNVLVTETVMAPAYAVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYTERVVPS-PSMTAMSNSSMTSG-------
--------CMGTGMSGS---------------------------------GMVGPDIQVT
Q--------------------------M-VSPDVHVCQT-----M--GSPMT-SRRRVTQ
HSTVQYFQQ----------------

------------------------------------------------------------
-------------------------------------------------SIQYQVVA--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLERPLELRVR VMDVNDNAPVFSMDTF VGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIISQEPSDAPMFIINRYTGEIRTMNNFIDRE----QYAQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMERPS YA--IS-IEENALHSELLQI---RV
IDLDEEYTANWIAVIFFISGNEGGWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSIGVRNKAEFHHSI-MSQYKLTATAVSVTVTNVIEGSVFRPGSKTYVVTSN-----
MGDNYKVGDFVATDLDTGRPSTT---V--RYVMGNNPAGLLAVDSRTGVITLRNRVTMEQ
YERLQGRYEGTILS--IDD---SL-QRTCTGTVVIDLNGSGWASG---------------
-----------------------------------------QSNS--Q------------
-----------------------------------------------------TNTNTPK
TGGGET-----TGGG--GNRG------------DVTTNEN--------------------
-----DVTPS-----DDSYND------YETNTGSYQGEGGLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGVGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPH------DIATICVPPML----PG-------
------------N-------------------GNIVECIDNSGVY--------TNEYCGR
EMQ-DMGGEERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEARPCNDCL---LIYDTEG-A--------GSPAGSVGCCSFIG-EDLDENFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---SWPPLNTEPIIPQQ-T--------E
PI------------------------------------------------ATG---HPPI
SPH----------YG--TTTVISESTY-PRGPGVQHPTPI-SDPLSY-GNVTVTESYTTS
-G--TLK---PSVHLHDNRHASNVVVTERVVGPISGTD-LHGIL------DMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSFTI-PNSRESSNVVVT
--ERVIQPTSGMMGS-LSMHPELSNAHNVIVTERVVSG-AGISGISGAAGMS--------
--------GGGNLCTSGL-----MSTSLGASG----------GGLSGT--GVSGGGIALS
NLGG----------------GTATIGNM-SSSDHHFSQT-----MGSASPSM-ARSRITK
YSTVQYSKQ----------------

------------------------------------------------------------
-----------------------------MAVLPAEGA-------WRLGALLLLICF--H
FG---NGLHLKVLHT-DNENGLISP-QGN-----LIRQKREWITAPVSLREGEDLSKKNP
IARIHSDLAHEQNIKVTYRYTGQGITEPPFGVFVFDKITGELNVTKI-LDREEVPMYILT
GYALDE--RGNNLERPLELRIKV LDVNDNEPVFTQDVF VGSVEELSPANTLVMKISATDA
DEKNHINSQVSYKIVSQEPAQPFVFFLDKDKGEILTTAFLLDRE----KHSHYSLIVEAS
DRSGQKTDKPVSRAKVQIN IL-DVNDNIPVAEFEMYE--NT-IEENQANVEVIRI---KV
TDLDEVGSDNWLANFTFISGNEEGYFHVETDSQTNEGIVT-LV-----------------
---------------------------------------------------KELDYEVLK
SLDLKIIVTN KAPFHKSI-RNKFKAKSIPIKIKVKNVVEGVYFQSQSIKVQTSE--QMER
SEIGKTIGKFQAYDQDTGKIA-HV-----TYAKGEDVDNWITVDPITSEIKLVKIPDYES
KYVINGTYIAKIVA--ITK--DIP-SKTVTGTIEIMVKDINDNCP-ELVNPVQTICD---
D-STYVNVTAKDLDGYPYSSPFSFAVIDKPAGMA-ENWYFGHQES--TSAW---LIPKEL
KIGRSEVHLSVSDNQGLSCPEKQILTLT--VCNCVSGSGCTEP-----------------
------------------------------------------------------------
---------------------------------------LFDPYVGLGSGAIGLMIFALL
----LLL--LLPLLLL--------------------LCHCGGGGG-----GAHGFTAIPG
-T-------VEMLHP---W-NNEGAPPEDKV------VTPLLAT-----DAGVNFGATPG
GLTR-VGI-ISSEST---------------KRGSSSGHHTMTVVD--GGWEEHRNLLTSG
ITR--TVGSAGAMS-GATTMGAAGAMSGATTMGAAGAMSGATTMGAAGAMSG--ATT--M
GAAGAMSGAT--MLGAAGAMGAV-GARTTTMALN-EEYLKNYFS----------D---KA
ASYVDNDEIQAAKDCL---LVYSQED-S--------QSLHGSIGCCSFIE-GDWDDSYLD
D-----LGIKFKMLAEICTGQKL-ETANEPSPG--HKLPTK----------AST-RTASH
SLYEQSTLQT-------------------EKSHSSSSGISLQ-----------------A
SKP--LSE---SPSETTKQELFAERSF-SSRQGLKVGRPG-PD-LPPGNI-VITETSYAS
-GSTLP----PSTLILNSRPPQSLVVTERVYAPTSALV---DQPL------VRQ-REDQS
NMVVTERVYAPASALVDQPLRQREDQSNMVITEVARPKGAMSGSLGNIMDVPDSSYVVVR
ERESFLAPSSGLQSV-MV-------------TEGGV------------------------
-------ASTSNLQAS---------------K-------------------TASLQKNL-
--------------------DLQESGPSHS-------------------MVTASSTRITK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVSST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMV-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEENENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSLKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------------------------------VVL--L
VH--GE-LRIETNGE-N---GTAVQ-QA------KRRYKREWVKFAKPCREGEDNSKRNP
IAKITSDFQATQ--KITYHISGIGIDQPPFGIFAVDRNTGEINITAI-VDREETPSFQIT
CRALNA--QGRDVEKPLILTVKI LDINDNPPVFSQSI FMGEIEENSPSNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMPMFLLSRHTGEVRTLTSSLDRE----QVSNYRLIVSGA
DRDGEG--L-SAQCESSIKV DYDVNDNFPMFKESQ YS--TR-IEENTLSSELLRF---QV
IDLDEEFTDNWLAVYFFTSGNEGNWFEIQTDSRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVQFSIAVKNKAEFHQSV-ISQYRVHSTPVTIQV INVQEGIAFRPAS KTFTVEKGI-SSK
KLVNYILGTYQAIDEDTGKAASNV-----RYVMGRNDGGLLIIDSKTAQIRFVKNMDRDS
TIIVNKTITAEVLA--IDE---NT-GKTSTGTVYVKVPGFNENCP-TTVLEKEVICS---
S-LPSVVVSARVQDNDKYTGPYTFSLEEQPQKLP-AVWSITTLNA--TSAL--LTAQQQV
SPGEYKVSLILKDSEERLCETPESLTLK--VCQCDYRDTYTNPT----------------
------------------------------------------------------------
--------------------------------------FHRQSSVRLGPAAIGLILLGLL
----LLL--LAPLLLL--------------------TCDCGT-GPAGG--VAGGFIPVSD
GS-------EGTMHQ---W-GIEGAQPEDKE------ITNICAP-LIT------------
-------------------------------SSGADF-VENSDVC--------TNTCARG
M-A--VEGA---S--GIELTTKLGAAAASGGAAASGAA------AGFGATTGLGFCSTVQ
S--GTMRTRHS-TGGTHKDYSEG-A-------IN-MNFLDTYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----LGAPGSPVGSLGCCSFIA-DELDESFLD
S-----LGPKFKKLAEISLECDD-KAKQSQTL---TKNGGSGAEFCSH----SIEIQQS-
------------------------------------------------------------
---------ESARCQTLPGSQGATALS-ASGSVLQPAIPI-PDPLQQ-GSYLVTETYSA-
SGS-LLQ---PSTAAFDPLLTQNVIVTERTFCPISNGS---GNLHGPT------ELRGSH
KMICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCELNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANTLVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFQMHPTPVRIKVVNVREGPAFHPSTMAFSVREGI-KGS
SLLNYVLGTYTALDLDTGNPATDV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDEPPGTA-DMWDVRSTNA--TSAI--LMAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAVGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAYALPGGGG--TADG-GG-SV
LGR----CALQAT------------------PALLNQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAVGLMATG----AA-----------------GA
S--GAARKRSS-TMGTLRDYADA-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DQCVQ---PTTIIFDPQLAPNVVVAEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
-----------------------------------------MARRVESALLLLLVCF--N
FG---NALHLEVLNA-RNENKLLPK-HT-----HLVRQKRAWITAPAALREGEDLSKKNP
IAKIHSDIAEERGIKITYKYAGKGITEPPFGVFVFNKDTGELNVTSI-LDREETPFFLLI
GYALDE--QGNNLEKPLELRIKV LDINDNEPVFTQDV FVGSVEELSAAHTLVMKITATDA
DEPNTLNSKISYRIVSQEPPYPPVFYLNKDTGELYTTSITLDRE----EHSSYALTVEAR
DGNGQITDKPVKQAQVQIRI L-DVNDNIPVVENEM YE--GT-VEENQANVEVMRI---KV
FDADEIGSDNWLANFTFVSGNERGYFRIETDTQTNEGIMT-LL-----------------
---------------------------------------------------KELDYEEMK
HLDLSIIVTNKVPFHKSI-KSKYKPTFIPIKV KVKNVKEGIYFKSSTISVRISE--SMDI
SSQSQIIGKFQAFDEDTGQLA-HV-----KYSKLEDIDGWVSVNSATSEIKLVKIPDFES
RYVQNGTYTVKILA--ISE--DTP-RKTITGTVVITVEDINDNCP-TLVNPVQNICD---
D-QQYVNVTAEDLDGYPNSDPFTFVIVDKPTGMA-KKWKVVHKES--TSVL---LQQNEQ
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCKCLDGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------LYDSYVGLGPAAIALIIFAFL
----LLL--LVPLLLL--------------------MCHCGESAK--SF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKL------VPSLLAT-----DHRESEAVSSG
VG-----GMTVKETT-MKG---------NSSASFTKVLHEMSETD--RRWEEHRSLLSGG
ATQ--VAGTTGAI-TGSETMRTTRA----I-----GASRD---------MA---------
-G----ARA------------------A-AVAVN-EEFLRSYFT----------E---KA
ASYTEEDDNHIAKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GELDDCFLD
D-----LEFKFKTLAEVCLGQKI-DMDMEIEQR--SKPLRE----------TSL-EAASH
SLFEQSRLNL-------------------ENAYS--SG-SFQ-----------------V
PKP--SRE---ANAEKITQETVTESSV-SSKHGQKVVTPL-PDPLASGNV-IVTETSFAT
-SSTMP---PPSTVILGPRQPQGLIVTERIYAPASTLV-------------DQH-YANEG
NVMVT--------------------------ERVLQPNGGISGPLEGIQHLPDEHYVMVR
ERESFLAPSSGIQPA-LAMPSV-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PAETSMASRK-----T-----MVSGT--GVSGPLPNF-
--------------------GLEESGLSSS-------------------TITTSSTRVSK
HSTVQHSYS----------------

------------------------------------------------------------
---------------------------MVRSLWSPGRRCEQPPPLPLLLLLLLLICF--T
FG---NGLHLETLNT-RSDSRLLPK-HT-----HLVRQKRAWITAPVSLREGEDLSRKNP
IAKIHSDIAEERGVKITYKYTGVGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLM
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFTEEVFVGSVEELSAAHTLVMKIIATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSIALDRE----EHSSYSLTVEAK
DDNGQITDKPVHQAQVQIR IL-DVNDNIPVVEREM YE--GM-IEENQVNVEVMRI---KV
TDADELGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMK
NLDFSIIVTNKAAFHKSI-RNKYKPTAIPIK VKVNNVKEGIHFKSSTISVRTSE--GMDK
S SQSQSIGKFEVFDEDTGQSP-HV-----KYVKLEDGDNWVSVDSVTSEIRLVKIPDFES
RYVHNGTYTVKVLA--VSQ--DHP-RKTITGTVLITVEDINDNCP-TLVNPVQSICE---
D-QPYVNVTAEDLDGHPNSWPFSFSIIDTPPGMT-EKWKIIRQES--TSVL---LQQGER
QLGRSEIPLLISDNQGFSCPEQQVLQLM--VCECLQGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------QRGSYVGLGPAAVALMILALL
----LLL--IVPLLLL--------------------LCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLAV-----DHGENLAARNG
VG-----GAITKEAT-RKG---------SSSASFSRVQHDLTEAN--GRWEEHRSLLSGA
AAQ--ATGTAGAQ-LGAETMRTVRA----V-----GASRD---------AT---------
-G----ARA------------------ASAGAVS-EEFLRDYFS----------D---KA
ASYSEEDDIHVAKDCL---LVYSQEE-T--------ESLHGSVGCCSFIE-GELDDSFLD
D-----LGLKFKTLAEVCLGQKI-DVDMEIEQR--PKPVKE----------TNL-TRAAH
SLYEQTTFNS-------------------DNTHS--SGSSFQ-----------------V
PKP--LHE---TKAEKLTQEIVTERSV-SSRQGQKVAPPL-PDPLASGNI-IMTETSYTT
-GSAMP----PSTVVLGPGQPQSLVVTERVYAPASTLV-------------GQQ-YAGES
NVVVT--------------------------ERVIQPNGGVPHPLGGTQHLQDAQYVMVR
ERESVLAP------T-LATPSAAAVGQNVTVTERVL------------------------
-------TPASTLESSYQI---ATEASGKAGR-----A-----MVSGA--GVPGPLPHS-
--------------------GLEGSGHSDS-------------------TITTSSTRVTK
HSTVQHSYA----------------

------------------------------------------------------------
------------------------------MDWFLFR---NI-----CLLILLMVVL--G
VN--SE-FIVEVKEL-DVENGNTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYSILSGNDGNWFEIHTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQIP
NIHLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFRPNSMTFSLREGV-RGD
SLMNYVLGTYTAIDTDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGIYAAEILA--IDD---GS-GRTATGTICIEVPDANDYCP-VIYAERRSVCV---
D-ASSVRIYV---SDHSFGSPFTFCVVDETSDTA-SIWNIRSINE--TSAI--LMTEQTL
SPGTHQIPILVTDSHNRACELPQTVLLD--ACFCDERHVCVHSSTTGIYNGDP------T
------------------------------------------------------------
---------------WVTEDTYGT----------GTDDGVGQSNVRLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------IC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGAG--TTAGLVAGG----A--------------------
A--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMEAASEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDSQLPSNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGMPDMGTSNMADA-------
--------CMGPMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSNSPMT-SQRRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------------------------ANEAYPEVP--N
VS---SKLHYKALNA-RSESKLLPR-RS-----HLVRQKRAWITAPVSLREGEDLSRKNP
IAKIHSDIAEERGIKVTYRYTGKGITEPPFGIFVFNKDNGELNVTSI-LDREEIPFYVLT
AYAMDS--RGNNLEKPLELRIRV LDVNDNEPVFTQEVF VGSVEELSAAHTLVMKITAEDA
DEPNTMNSKISYRIVSQEPAYSPVFYLNKDTGEIYTTSIALDRE----VN----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------ICF--N
FG---NGLHFETLNT-RNENKLLPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDVAEEKGLKITYRYTGKGITEPPFGLFVYNKDTGELNITGI-LDREETPFFLLM
GYALDA--NGNNVEKPLELRIKV LDINDNEPVFTQNV FAGSVEELSARDTLVMKISATDA
DEPNTLNSKIFFKIVSQEPA--SVFYIKPDTGEIYT-SMNLDRE----EHSSYTCIVEAT
DSYGQITSRPATQAQVQIQI L-DVNDNIPTVEKEV YE--GS-VQENQANVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAVTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSV-MNKYKPTPIPIKVKVKNVQEGIHFKSSTIYINVSE--SMDQ
SSKGKTIGKFEAFDEDTGQVAR-V-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--XXX--XHP-GKTITGTIAVTVKDINDNCP-RLVNPVQSVCE---
E-TPYVEVTAEDLDGYENSEPFSFSVVDEPPGTA-EKWKMVQQKS--TSVL---LQQREQ
KLGKSEIQFLIKDAKGFSCPEKQILQLT--VCKCLDSSGCVAF-----------------
------------------------------------------------------------
---------------------------------------YQDSYIGLGPAAVMLIILALL
----LLL--LLPLLLL--------------------MCHCGEGAR--GF------TAIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLAA-----DLGVSPAVGNE
AG-----ALLTKETA-MKE---------SSDASFSRVRQEMSEMD--ARWEGHRSLISNG
ATQ--VTRTPGAV-TGTETRRATRT----T-----GVTRD---------AA---------
-G----AR-------------------SAAVAVN-EDFLRNYFT----------E---KV
ASYTEDSDVHTAKDCL---LVYSQEE-T--------ESLHGSLGCCSFIE-GELDDRFLD
D-----LGFKFKTLAEVCTGQKI-DTDMEIEQR--QTTVTE----------ASK-HTASR
PHYEQTMVNS-------------------ENTYS--SGNTFQ-----------------V
SKP--VQE---AKAETVTQELVTERSL-SSRQGQKVVTPI-PDPLVPSNV-VVTETSYAT
-SSTVQ--------------PQGLIVTERVYAPASALI-------------DQP-YANES
DVLVT--------------------------ERVIQPNEGVLNPFEVPQYRPDAHYVMVQ
ERERVLAPDLSAQPS-LAVPGI-AARQNVTVTERVL------------------------
-------TPASTLQPSHQA---PANTSTMARK-----T-----MISGA--SVAGPRPKF-
--------------------GLEESAS-SS-------------------TMTTSSTRVTT
QSTVQQSYS----------------

------------------------------------------------------------
------------------------------MDWSFFRT--A------AVLFIFL------
-----------VRDY-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPYFIIY
CQALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTFI GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGL-SAECECNIKI L-DVNDNIPYLEQTT YS--VN-IEENALSSNALQL---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGTLK-II-----------------
---------------------------------------------------KPLDYEAMK
SLQLSIGVRNKAEFHQSI-MSQYKLTATAISVIVSNVIEGSVFRPGSKTFAITPN-----
MGVNQRVGEFIATDLDTGRASTT---VR--YVMGYNPADLLSINSKTGIITLRNKITKEQ
YDMLRGKYQGTILS--IDD---TL-QRTCTGTVNIDLQGWEERTN---------------
-----------------------------------------ENTG--T------------
-----------------------------------------------------TDTTTSG
N--------------NLNGGGTS----------S-------------GVNTWSDG--VTT
NP------------------E-----DIITTPGRAVSDYTLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---PG--VGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRG-----LT-TIPVTQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYSGR
EMQ-DLGGGERTT--GFELTDGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDI-EPYPDPDP---SWPPQSTESVCLHQET--------E
AI------------------------------------------------ARG---HPPI
SPH----------FG--TTTVISESAH-PSGPGVQHPMPI-SDPLGY-GNVTMTESYTTS
-G--TLK---PSVHVHDSRHASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTTLTI-PNPRESSNVVVT
--ERVIQPASGMIGN-LTMHPELANAHNVIVTERVVSG-AGVTGAAGISGG---------
--------G--GI------------GSMGTGA----------GGLSGA--GVSGGGIGLS
SLGGGGGLS--------SMGGAATIGHMRSSSDHHFSQT-----LGAASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---QVVDSDRPE--GSKFRLTGKGVDQEPKGIFRINENTGSVSVTRT-LDRETMATYQLF
VETTDV--NGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPT------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRS---------YALLLLLICF--N
VG---SGLYLQVSST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARGPAAG-----G--LEALLLLTICL--N
FG---NGIHLEVFNQGG-KMDHLSN-QN-----SKIRQKREWIVPPATVSEEDDSLKINP
IARISSDHASDPGVTITYLISGQGVTEPPYKLFIINGKTGELNITRK-VDREQHSMFYLK
AYALDQ--NGKNMEKPLDLRIK VNDINDNYPIFSEEVFF GSVEELSETATFVMRINATDA
DEPNNLNSKIAFKILSEKPYEPSAFHIKKNTGEIITATFNLDRE----EQSNYILTVEAR
DRNGDRNGL-AKTCTVKIKI L-DVNDNLPILERET YE--GS-VEENRANVEIIRM---KA
FDKDEIFSDNWLANFSIVSGNEGGYFHIETDTQTNEGVLT-LV-----------------
---------------------------------------------------KELNYEEIQ
SMSLGIVVTNKAAFHKSI-QNSYKAKSIPVTV KVKNVLEGPVFKPHTMVIK TSEI-----
IKINQIIGTFQAYDEDSSKVAENV-----KYLKGYDKDNWIMIDSSSAEIKFVKVPDYES
IYVNNGTYTVTILA--ITQ--DYS-KKTATGTIVIKVEDINDNCP-IILTPAQTVCS---
D-AKFFSFTAEDRDAYPNSAPFTFTVIDEPEGTA-KKWLIEGVNE--TSIH--LLLPEDI
KPSTNQVQMLVKDMQGLSCAEKQILTLS--VCTCVDGGSCQDR-L---------------
------------------------------------------------------------
---------------------------------------IN-SSVGLGAGAIAVIILAIL
----LLL--LVPLLLL--------------------LCRHGSGAK--GF------TAIPD
NS-------EEILRK---W-NNEGAVPENKA------PLSFIAPPPLSISEAKG------
-----RSGGAAVEAV--------GS-GGSSSVSHIKEHHANSIIN--RRWEEQR-FLSGA
DYG--AGGATRMGAGGATTMGAGRA----TMMGPGGVTPM---------GAGG-TMA--M
GP----GGVT--TMGAGG--T---TAMGIEGAIN-EEFLRDYFN----------D---KA
DTFAGEDEAQLAKDCL---LLYCQEE-G--------DSPPGSIGCCSFIE-DDLDDRFLD
D-----LGDKFKTLADICLGKRA-EVEVSQHSS--HVLKDRNARPAVNESGLHLNNALPQ
FLDQQSAFNS-------------------EHTYS--FDPSFQ-----------------P
PEP--VHRVNGVGSETVTRKAFTETPYAXXXXXXXXXXXX-XXX-XXXXXXX--------
-----X----XXXXXL--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVTTRTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYTDG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-ESKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQV
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRSPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYAEG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ISGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNVAGPA------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVML--E
VN--SE-FIVEVKEL-DIKNGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCELNQ--KITYRISGIGIDRPPYGVFTINPRTGEINITSV-VDREVTPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFTQSV YTASIEENSEANSLVVKLSATDA
DEENHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSYLDRE----QHSMYNLIVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNEGNWFDIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NVHLSIGVKNEADFHHSV-ASQFQMHSTPVRIQVVNVKEGPTFHPSSLTFSVPEGI-KGD
SLLNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGKIQFSREFDQKS
KYISNGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-DIVPDRRTICT---
D-SPSVLISV---NEHSYGSPFTFCVVDQPPGTA-DMWDIRSVNA--TSAI--LMTEQPL
SLQLYEIPIVVKDSYNRVCDSSQIVQLY--ACDCDTNHMCLDSSITGIHTGDI-------
------------------------------------------------------------
-----------------TSDTYGP----------VTEDQTEVSNVGLGPAGIGMMSMGGL
----LLL--MSPLLLL--------------------MC-CCKGKQPQG--LGTSFAPVPE
GG-------EGVMQT---W-RIEGAHPEDRD------VSNI-------------------
-------CAPMT-------------------ASNTQDRMDTSEIY--------NNTYAGG
GTV--EGGV---S--GVELNTALG--TATGLVAGG------------------------A
T--GAVRKRSS-TMGTLREYADT-G-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-PSEAEFQAEMAT-PEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDPQLPPNIIVTETVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERILAS-PGVPDMSNSSMTEG-------
--------CIGPVMSGG---------------------------------ILVGPEIQVA
R---------VA-----------------S-PDIPTGQT-----MGSASPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVKC--E
L------PLLKVKEL-DMENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNAPVFTQNI YTASIEENCNANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVHTMSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IKENCLSSELIRL---QA
IDLDEEGTNNWLAKYVILSGNEGNWFDIQTDPETNEGILK-VI-----------------
---------------------------------------------------KTLDYETMP
NVHLGIGVKNQAEFHHSV-ASQFRMHSIPVRIQIINVKEGHTFHPSSKTFSVREGI-TGH
SLLTRVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IED---GS-RKTATGTICIEVPDANDYCP-VVYSETNIICT---
N-SPSVLIYV---RDSSYGAPFTFCVVDQPPHTA-QMWDIRPIND--TAAI--LMTEQIL
SEQLYQVPILVKDSYNRQCELAQIVQLN--ACDCDSNHVCWQWSTTGIYNGDV------S
------------------------------------------------------------
---------------SVTADMNGF----------ATDHGVEDSNVGLGPGGISMIVLGLL
----LVL--LSPLLLL--------------------MC-CCKRRQPEG--LGTGFAPVPE
GG-------EGVIQP---W-RIEGAHPEDRD------VSHICGPM---------------
------------T------------------ASNTQDHIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVDLNTAVG--TAG----GP----A--------------------
A--GASGKRSS-TMGTLREYADA-G-------LN-AAFLDGYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDEGYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAT-AEPVIH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPSVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHDVYHAERVLAS-PGMPDMNSAGMADA-------
--------CVGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGCTSPMT-PRHRVTR
YSNIRYSPQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLMILMVVL--E
VN--SE-FIVEVKEL-DMENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEVNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPIFLIY
CRAL--NSRGEDLERPLELRVKV MDINDNPPVFTQNV YTASIEENCDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----EHSMYTLFVSGS
DRDGAPDGL-SANCDCRIKV L-DVNDNFPTLEKTA YS--AS-IEENCLNSELMRL---KA
IDLDEEGTANWLAEYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NIQLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQV VNVREGPTFHPSS MTFSVREGL-RGD
SLLNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSRELDKKS
KYVTNGIYTAEILA--IDD---GS-GKTATGTICIEIPDVSDYCP-VVFTEGRTICI---
A-SPSILISARGINDNAYGAPFTFCVVDEPPGTA-DLWDARTING--TSAI--LTAKQPL
FPGSYQIPILVTDSFNRACELPQIVHLD--ACDCDSDHTCLYYSTTSIYTGDVVSAT---
------------------------------------------------------------
-----------------SDGGDGF----------VTGDRLGESNVRLGPGGIAMIVLSLL
----MLL--LAPLLLL--------------------IC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVIQS---W-RIEGAHPEDRL------SGTSVLCHGDA------------
VDV------CRAL------------------RSSVRENPVFSEIY--------TNTYAGG
AIA--EGGA---S--GVELNSALG--TAAGLVAPG------------------------A
A--GATRRRSS-TIGTLREYAES-G-------VS-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSC---SGV-----DDDECM
T-----LDP-F-RTAEICLDTEI-EPFP--HL---ACIPINT------------DLPLIG
PNY---------------------------------------------------------
-----------------F-VNESSGKT-LSEAEFQAEMAM-PDPIAH-GDIIVTETYTTA
--DQCVP---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICIPAELTNTHNVIYTERVLSS-PGVPAMSTGSMADG-------
--------CLGPLMSGS---------------------------------ILLGPEIQVV
------------------------------TPDVRITQT-----TGSTSPVT-SQRRVTQ
YSNIHYTPQ----------------

------------------------------------------------------------
-------------------------------------------------MTLFPVLT--A
SPLAYYLNPQTALHS-RNESKLLPK-HI-----HPVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKKLKITYKYTGKGITEPPFGVFVFNKDTGELNVTTI-LDREETPFFLVT
GYALDE--RGKNLEKPIELRIKVLDINDNEPVFTQDVFVGSVEELSAANTLVMKINATDA
DEPNTLNSKISYRIVSQEPANSPVFYLNKDTGEIYTTSITLDRE----EYSSYTLIVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVDRNV YE--GS-IEENKANVEVLRI---KV
SDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYETMK
NLDLSIIVTNKAAFHKSI-KDKYKPTSIPIK VKVKNVKEGIYFKSSTIQFHTSE--SMEK
LSQGQILGKFQVFDEDTGKVP-NV-----KYAKFEDIDNWISVNSATSEIKLVKIPDYES
RYVQNGTYTAKIVA--ITE--EYP-RKTITGTIVINVEDVNDNCP-TLVEPVQTVCD---
Y-VPFVNVTAQDLDGPQNSWPFSFSIIDKPAGMA-ERWKIVRRED--NNVL---LQQTKR
QHGTSEIHFQIADSQGFSCPEEQILRLT--VCNCVEGSGCVNM-----------------
------------------------------------------------------------
---------------------------------------WADSYVGLGPAAIALIILALL
----LLL--LIPLLLL--------------------VCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VLPLLGA-----DVRDGAAV---
-GAGAGGGVTAKEAI-VKG---------SSSASFSKGQQEMSEAE--GRWEEYRSLVSGG
ATQ--VTGTTGAM-VTSDTFRTTRA----T-----GAARE---------VA---------
-G----AR-------------------AGAVAVN-EEFLRSYFT----------E---KA
ASYIGEDDMHTAKDCL---LVYSQED-T--------ESLRGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGRKI-EMDAEIQQR--AKPARE----------ADR-KVVSQ
SLYEQTRLNS-------------------ENAYA--SGSSFQ-----------------G
PKP--LHE---ADTEKVTQEIVTEKSVISSKQAQKVAAPL-PDTLASGSV-IVTETSYAT
-GATGP----PSTVVLGPQQSQGLIVTERVYAPASTLG-------------NQQ-YASEG
HVVVT--------------------------ERVIQPHGGTSGLLEDAPPLPDAHYVMVQ
ERERFLTPSSSLQPP-LAAPSV-ALGQNVTVTERVL------------------------
-------TPASALQSSYQI---PAETSVMSRK-----T-----VASAA--GVPGSLPDS-
--------------------GLEESSHSNY-------------------TITTSSTRVSK
QSTVQQSFS----------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAIFVVVI--L
VH--GE-LRIETKGQ-YDEEEMTMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRDSQ YS--AR-IEENILSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGI-SSK
KLVDYILGTYQAIDEDTNKAASNV-----KYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPDFNDNCP-TAVLEKDAVCS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
PPGVYHISLVLTDSQNNRCEMPRSLTLE--VCQCDNRGICGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKEVQPP---SKDSGYGIESCGH----PIEVQQT-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-TSGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWRFFR--VA------VVLFI--------
---------FLVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--IA-IEENTLNSNLLQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVKNKAEFHHSI-MSQYKLTATAVTVT VLNVIEGPVFRPGSKTYVVTGN-----
MGS NDKVGEFVAIDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTININIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTGREES----------T-------------SSTDYETSTSSGV
SQ------------------Q-----PNSNGNQNGGRVPLFADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGAQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSG-LGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGT--GISGGGVGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
---------------------------------LIQ---KCL-----GTIKCLQVVL--L
VH--GE-MRIEVKYE-KFFDER-AA-WR------KWRHKREWVKFARPCREEEDNSKRNP
IAQISSDFHAKQ--KITYRITGIGIDQPPLGIFVVDRNTGDINITAI-VDREQTPNFHIT
CHALNA--LGQEVEKPLILTVKI LDINDNPPVFSQSV FMGEIEENSPANSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGIPMFLMSRHSGEVRTLTNSLDRE----QVSSYRLIVSGA
DQDGEG--L-SSQCESSIKV K-DVNDNFPMFKESQ YS--VS-IEENTLSSELLRF---QV
IDLDEEFTDNWLAEYFFTSGNEGNWFEIQTDARTNEGILK-VV-----------------
---------------------------------------------------KPLDYEQLQ
NAQFSIAVKNKAEFHQSV-ISQYRVQSTQVKVQV INVREGIAFRPAS KTFTVQKGI-SRK
KLINYILGTYAAIDEDTGKPASNV-----RYALGRNDGGFLIIDSKTAQIKFARNMVRDS
TFIFNRTIIAEVLA--IDE---NT-GKTSTGTVYVEVPGFNENCP-TTVLEKERICS---
S-SPSVVVSARAQDGDRYTGPYTFSLEDESVKLP-IVWRITTVNA--TSAL--LTTQQQL
PPGRYPISLVIADRQDRQCDTPEGLAVE--VCQCDNRDTCTEPQP---------------
------------------------------------------------------------
-----------------------------GP------RYGDQPSGRLGPNAIGLILLGLL
----LLL--LAPLLLL--------------------TCDCGK-GPIGG--ATTGFIPVPE
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-LIT------------
-------------------------------SNGADF-MENSDVC--------MNACARG
M-T--AEGA---S--GMELTTNLGAAAGSGAATGSGAA------AGFGATTGLGFCSAGQ
S--GTMRTRHS-TGGTHRECGEG-V-------IS-MNFLESYFS----------Q---KA
FACAEQDDGQEANDCL---LIYDNE--G----LGAPSSPVGSLGCCSFIA-DDLDESFLD
S-----LGPKFKQLAEISLGLDG-KGQQSQLP---THGSGSGTGACGH----SVEIQHS-
------------------------------------------------------------
---------ELSGGQTTSGGQGACAWS-ASGSVLQPAICI-PDPLQQ-GGYLVTETYSA-
SGS-LAQ---PPTAALDPLLMQNVVMTERVICPIASGH---GHLHGAA------ELRGSC
NMIYT--------------------------ED-----------PC--------------
--SRL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NV-----CLLIILMK-----
-H--EP-FWLQVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCESNQ--KITYRISGIGIDRPPYGVFTINPRTGEINITSV-VDREVTPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFTQSV YTASIEENSEANSLVVKLSASDA
DEENHLNSKIAYKIISQEPAGVPMFILNRYTEKFAQMSSYLDRGGKPSQHGMYNLIVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLNSELIRL---QA
IDLDEEGTDNWLAKYLILSGNEGNWFDIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NVHLSIGVKNEADFHHSV-ASQFQMRSTPVRIQVVNVKEGPTFHPSSLTFSVPEGI-KGD
SLLNYVLGTYTAIDLDTGNPAKNV-----RYIIGHDAGSWLKVDSRTAKIQFSREFDQKS
KYISNGIYTAEILA--IDD---GS-GKTATGTICIEVPDPNDYCP-DIVPDRRTICT---
D-FPSVLISV---NEHAYGSPFTFCVVDQPPGTA-DMWDIRSVNA--TSAI--LMTEQAL
SQQLYQIPIVVKDSYNRVCDSSQIVQLY--ACDCDTDHVCLDSSLTGIHTGDI-------
------------------------------------------------------------
-----------------T----------------VTEDQTEVSNVGLGPAAIGMMSMGGL
----MLL--MSPLLLL--------------------MC-CCKRKQPQG--LGTSFAPVPE
GG-------EGVMQT---W-RIEGAHPEDRV------SGPSLSGKEW------ADSTGNV
LDA----CGVQTI------------------PAPVREHPLFSEIY--------NNTYAGG
GTV--EGGV---S--GVELNTALG--TATGLVAGG------------------------A
T--GAVRKRSS-TMGTLREYADT-G-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VSESSGMT-PSEAEFQAEMAT-PEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDPQLPPNIIVTETVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERILAS-PGVPDMSNSSMTEG-------
--------CIGPVMSGG---------------------------------ILVGPEIQVS
R---------VA-----------------S-PDVPTGQT-----MGSVSPMT-SRHRITR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------------------------------------
-N--SE-FRIQVRDY-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--KVTYRISGVGIDQPPYGVFVINQKTGEINITAI-VDREVTPFFIIY
CRALNS--QGQDLERPLELRVRV LDINDNPPVFSMSTFI GQIEENSNANTLVMTLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEQST YS--VS-IEENALHSELLQL---RV
IDLDEEYTANWMGVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSIGVRNKAEFHQSI-ISQYTITATAVSVTVVNVVEGSVFRPGTKTYVVTSN-----
MGANYKVGDFVATDLDTGLASTN---V--RYVMGNNPAGLLAVDSRTGKITLRNRVTMDQ
YQMLGGRYQGTILS--IDD---AL-QRTCTGTVIIDLDGSGWGPG---------------
-----------------------------------------SETN--T------------
-----------------------------------------------------TSGDSSG
SGTSGS--------SSGNG---------------------------------GSGT----
-----------------------------YDNTDGTDRQVLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GLATICVPQIQ----PG-------
------------T-------------------ANLIECIDNTGVY--------TNEYCGR
EMQ-DMGGGDRTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------SSMREC---------------MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDTEG-A--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-EAYPDPDP---SWPPQTTEIICPQQ-T--------E
PH------------------------------------------------ATG---HPPM
SPR----------FG--TTAVISENTY-PSGPGVQHPLPI-SDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNRHASNVVVTERVVGPISGAD-LQGML------EMPDLRDGP-
NVIVT--------------------------ERVIAPGSGLPTSLTI-PNARESSNVVVT
--ERVIQPTSGMMGG-LSMHPELPNAHNVIVTERVVSG-AGMSGIGGTTGIG--------
--------AVGGIGSSGL-----VSASVGSGG----------GGLSGA--GVSSGGGGGL
S----------------HVGGTATIGHVRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVKC--E
L------PLLKVKEL-DMENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNAPVFTQNI YTASIEENCNANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVHTMSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IKENCLSSELIRL---QA
IDLDEEGTNNWLAKYVILSGNEGNWFDIQTDPETNEGILK-VI-----------------
---------------------------------------------------KTLDYETMP
NVHLGIGVKNQAEFHHSV-ASQFRMHSIPVRIQIINVKEGHTFHPSSKTFSVREGI-TGH
SLLTRVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IED---GS-RKTATGTICIEVPDANDYCP-VVYSETNIICT---
N-SPSVLIYV---RDSSYGAPFTFCVVDQPPHTA-QMWDIRPIND--TAAI--LMTEQIL
SEQLYQVPILVKDSYNRQCELAQIVQLN--ACDCDSNHVCWQWSTTGIYNGDV------S
------------------------------------------------------------
---------------SVTADMNGF----------ATDHGVEDSNVGLGPGGISMIVLGLL
----LVL--LSPLLLL--------------------MC-CCKRRQPEG--LGTGFAPVPE
GG-------EGVIQP---W-RIEGAHPEDRD------VSHICGPM---------------
------------T------------------ASNTQDHIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVDLNTAVG--TAGGLASGP----A--------------------
A--GASGKRSS-TMGTLREYADA-G-------LN-AAFLDGYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDEGYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAT-AEPVIH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPSVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHDVYHAERVLAS-PGMPDMNSAGMADA-------
--------CVGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGCTSPMT-PRHRVTR
YSNIRYSPQ----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MKINATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYSLIVEAR
DGNGQITDKPVKQAQVQIRV L-DVNDNIPRVEDEM YE--GM-VEENQVNVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQPNEGIVT-LI-----------------
---------------------------------------------------KXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX--XXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----XYAKLEDIDNWVTVDSVTSEIRLAKTPDFES
RYVQNGTYTVKILA--ISE---YP-RKTXXXXXXXXXXXXXXXXX-XXXXXXXXXXX---
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX--TSVL---LQQRER
KPGRSEIQFLISDSQGYSCPEKQILKLT--VCKCLDGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------LRDSYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------FCQCGESAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPPLLAA-----DHGESLVVRNG
IG--GVGGAMTKETT-MRG---------SSSASFTKVQHDMSEMD--GRWEEHRSLLSGG
ATQ--VTATAGAI-TGTEAIRTTKA----T-----GASRD---------MA---------
------------------------GAQVAGVAVN-EDFLRNHLT----------D---XX
XXXXXXXXXXXXXXXX---XXXXXXXXX--------XXXXXXXXXXXXXX-XXXXXXXXX
X-----XXXXXXXXXXXXX-XXX-XXXXXXXX---XXXXXX----------XXX---XXX
X-XXXXXXXX-------------------XXXXX---XXXXX-----------------X
XXX--XXX---X-XXXXXXXXXXXX-X-----XXXXXXX--XXXXX-XXX-X-XXXXXXX
-X-XXX----XX--XX--XXXXX-XXXXXXXXXXXX-X-----X-------XXX-XXXXX
XX-XX--------------------------XXXXXXXXX-XXXXXXXXXX-XXXXXXXX
-XXXXXXX-XX-XXX-XXXXXX---XX-------------------------------XX
XXXXXXXXXXXXXXXXLTV---PVAVQNVVTERVLAAALADTSKARNT--RVLGPLTNF-
--------------------GLEESSLANS-------------------SITTSSTRVTK
HSTIQHSYS----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------RQKRKWIEFTADCREGEDNSKRNP
IAKIRSDCEENQ--PIVYSISGIGIDRPPYGIFAINKNTGEINITSI-VDREVTQRLLIT
CYAKHA-ITNREVEPPLVLRI RVLDINDNAPVFSQAVHMG SIEESRMETTLVMKLITMDA
DEPNNLNSKIAYKIMGQEPAGASMFILSRDSGEVH-IANFLDRE----QYDRYSLVVRAS
DRDGAADGI-SSQCTCSIEVI-DVNDNFPTLLQNSVSFFSP-IKSN--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
--------------------------------------------------KLIIVVA--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------PRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPYFIIV
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDAPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEPSLQR--VI -IEENTVNSNLLQL---RV
IDLDEEFTANWIGVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSFGVRNRAEFHQSI-ISQYKITATVVSVTVKNVIEGSVFRPGSKTYVVTSN-----
TQANQKVGEFIATDLDTGLASTTFS-FKYRYVMGDNPTDLLAVDSRTGVLTLRNRVTMEQ
YQMLKGRYQGTILS--IDD---SL-HRTCTGTIIIDIEGFGGPGT---------------
-----------------------------------------QSST--D------------
------------------------------------------------------------
----------------------------------------------------G-------
--------S------TN--T---------N-----------TDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCSGA---PG--GGAGFEPVPE
CS-------DGAIHP---W-AVEGPQPDPGDPRFGHDVNSVCIPSIP----GG-------
------------G------------------A-----MIDSSGVY--------TNDYCAG
EMQ-DLGGGERTT--GFELMEGVKTSAAP------------------------EMCQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
FAYADEEEGRPSNDCL---LVYDIEG-A--------GSPAGSVGCCSFIG-EDLDDGFLD
T-----LGPKFKKLADISLGKEP-ESYPDPDP---SWPPQTTEPTYPPQ-----------
-----------------------------------------------------------V
SQQ----------VG--TTMVVSESTY-PSGPSVHHPLPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNLHAPNVVVTERVVGPISGAD-LHGML------DMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-PTPIESSNVVVT
--ERVIQPTSGMIGS-LNMHP---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------XXXXPGRA---------YALLLLLICF--N
IG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVANKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISIYVSE--S MDR
SSKGQIIGNFQAFDEDTGLPA-HA-----RYVKLEDRDNWISVDSVTSEIKLAELPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLINVEDINDNCP-TLIEPVQTICH---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGDSLVGRNG
VG-----GMA-KEAT-MKG---------SSSASIVKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--FTGATGAI-MTTETTKTARA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SLYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNV-IATETSYVT
-GSTMP----PTTVILGPSQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQP--LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMKARN-----T-----TVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------------------------NNFILQICF--H
VG---SGLYLQVSST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGYPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLALT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEENENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSLKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVEHSYS----------------

------------------------------------------------------------
------------------------------MDWLPFR---NI-----CLLIILMXXXXXX
XX--XX-XXXXXXXX-XXXXXXXX-XXX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXX-XXXXXXXXXXXXXXXXXXXX-XXXX-XXXXXXXXXXXX
XXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-XXXXXXXXXXL-DVNDNFPTLEKTSYS--AS-IEENCLSSELIRL---Q-
IDLDEE-TDNW-ANYFILFWNDGNWXXXXXXXXXXXXXX---------------------
------------------------------------------------XXXXTLDYEQMP
NIL--GGVKTQAEFHPPV-ASQFRMQSTPVIIQVINVREGPTFQPDSMTFSVREGL-RGD
SLLNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIRFSREFDQKS
KYITNGIYTAEILA--IDD---RS-GKTATGTICIEVPDANDYCP-VIFSESENICI---
G-SPAVVIYV---SGHSYGSPFTFCVADQPPGTA-DLWDIRSINA--TSAI--LMSEQLL
ISGIYQVPIVVKDSFNRACELPQVIQLQ--ACDCDDNHVCLYSSTTGIYGSAT-------
------------------------------------------------------------
------------------NDI--Y----------ITEDQVGGSNVGLSRTGIGMIALGAL
----LLL--LSPLLLL--------------------IC-CCKRRKPVG--LGTRFAPVPE
GG-------EGVIQS---W-GIEGAEPEDRT------CRYYPSLLGDGTS----------
-DT----C----A------------------TSARLYKSLLSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGG-IGAAAGLAAGG------------------------A
S--GALRRRSS-TQGTQWEYTDN-G-------LN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAM-AEPLIH-GDIVVTETYTTA
--DQCMQ---PTTIVFDPQLASDVVVTETVMAPVYDV----GN-----------------
------------------------------------------------------------
----------------ICIPAELAXXXXXXXXXXXXXX-PCMPDMNNSSMTDG-------
--------C-----------------------------------------ILVAPEIQVT
Q---------MM-----------------S-PDIHISQT-----IDSTSPMT-SRHRVTR
YSNIHYSPQ----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------AVLLIFLVVL--E
VN--SE-FHIQVRDH-NAKNGTIS-WHT------IRRQKREWIKFAAACL----------
-GKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTF TGQIEENSNANTLVMKLDATDA
DEPNNLNSKIAFKIIKQEPSESPMFIINRGTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAECECNIRI L-DVNDNIPYLEQSS YA--IS-IEENALHSQLVQM---RV
IDLDHVLSDNWKAVLFFISGNDGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNVAEFHQSI-ISQYRITATMITVNVLNVIEGSVFRPGSKTFVVNSQ-----
MGANYKVGDFTATDLDTGLIS-----TNVRYVMGNNPADLLDVDSRTGIITLRNRVTMEQ
YQMLNKRYEGTILS--IDD---NL-QRTCTGTVIIDLDGSGWVTS---------------
-----------------------------------------TDTN--T------------
-----------------------------------------------------SGGGGST
GGGGSAGSGT-SENTSTEETQVTTGS-----------W--ENGNN------GYDGNDG--
---------------------------------DGSDRQRGGDNVHLGPAGIGLLVMGFL
----ILG--LVPFLLL--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQMP----PG-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKASAGP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPEP---SWPPQMT------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------ERVIAPGSSLPTTLTI-PNPREPSNVVVT
--ERVIQPTSSMMGN-LSMPPELSNAHNVIVTERVVSG-ALASGISGATGIG--------
--------GVGGVGGSSL-----VSTTMGARG----------GG-------------L--
---------R-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXVQYTK-----------------

------------------------------------------------------------
------------------------------TMRLLP---RTS-----GALAILMVVI--L
VH--GE-LHIETKGQ-HEEDRTAVQ-QT------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDQNTGDINITAI-VDREETPSFLIT
CRAVNA--LGQDVEKPLILTVKI LDVNDNAPVFSQSIFM GEIEENSASNTLVMILNATDA
DEPNHLNSKIAFKIVSQEPASTPMFLLSRNTGEIRTLTNSLDRE----QVSSYRLVVSGA
DKDGEG--L-ATQCECSIK VK-DVNDNFPVLRDSQ YS--AH-IEENTLSSDLLRF---QV
TDWDEEYTDNWLAEYFFTSGNEGNWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
TLQFGIAVKNKAAFHQSV-ISKYRVQSTPVTIQ IINVKEGITFRPASKTFTVQKGI-SSK
KLVNYIVGSYQAIDEETGKAASYV-----RYIMGRNDGGFLMIDPKTAQIKFVKNLDRDS
TFIVNKTITAEVLA--IDE---TT-GKTSTGTIHVEVPNFNENCP-TVVLEKQVVCS---
S-SPSVVVSANALNNVKYTGPYTISLEEQPIKIP-AVWSITTLNA--TSAL--LKAQQQI
SPGVYKISLVITDSQNNQCETPESLTLE--VCQCDNRDTCGTYVPNRDP-----------
------------------------------------------------------------
-----------------------------GV------KYGKPASGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGT-GPAGG--VTSGFIPVPD
GS-------EGTIHQ---W-GIEGAHPKDKE------ITNICVP-PIT------------
-------------------------------ANGVDF-MESSDIC--------THTYAGG
T-V--VEGA---S--GMELTTKVGAATGSGGATGFTAGTVCGAAGGFGAASGLGICPAGQ
S--GTMTTRRS-TGGAHRDYADG-L-------IN-MNFLDSYFS----------Q---KA
SAWAEEDNGPESNDCL---LIYDNE--G----PDAAGSPVGSLDCCGFIT-DDLDDSFLE
S-----LGPKFKKLAEIILDGDR-EATQAPLP---TKESGYGVDSCGR----TREVPQS-
------------------------------------------------------------
---------GPRRYQTLSGSEGASAVS-ASCS-LQPAIPI-PDPLQH-GNYLVTETYSA-
SGS-LVPPVPPSAAVFDPLLTQNVIMTERVICPISSVP---GNLAGPT------QLRGSR
TMLCT--------------------------ED-----------PC--------------
--SRVI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEENQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVKV MDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECNCRIKV L-DVNDNFPTLEKSS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKFLILSGNDGNWFDIQTDPQTNEGILK-VVKVHPLCQSETCSSATRS
LLPRAVASRVFMEGNKDDKITTNSINR-TYRWLFSGKVLEFFYF----LSFQMLDYEQMP
NIHLGIGVKNQAEFHHSV-ASRFQMHSIPVRIQV VNVKEGPTFHPNS MTFSIREGI-RGN
SLLNYALGTYTATDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-VVFAESDYICI---
A-SPSILISARDIGDHSYGSPYTFCVVDQPPGTA-DLWDIRSINA--TSAI--LTAEQLL
NPIVYQIPIIVKDSYNRACELPQIVALE--ACECDNNHMCLYSSTTGINVEDG------S
------------------------------------------------------------
---------------SATSDIYGT----------VTDEQAGGSNVGLGPTGIGMIAMGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------DGVMQS---W-RIEGAHPEDRD------VSNICVPM--T-----A------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GMV--EGGV---S--GVELNTGLG--TAAGLAAGD------------------------S
A--GARRRRSS-TIGTQWEYADM-G-------LN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VSDSSGMT-LSEAEFQAEMAI-PEPMTH-GDIVVTETYTTA
--DQCMQ---PTTIVFDPQLAPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVLSS-PGMPDVSSDSMTDG-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PNVHISQT-----TSSTSPVT-SRHRVTQ
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILTVVL--E
VN--SE-FVVEVKEL-DAENGTAK-WQT------VRRQKREWVKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEETSDANTLVVKLSATDA
DEENHLNSKIAYKIVSQEPAGSPMFIMNRYTGEVRTTSNLLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRF---QT
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQVVNVREGPAFHPNSMTFSVREGL-KGN
SLLNFVLGTYTAIDLDTGNPATNV-----RYIIGHDAGNLLKIDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-VKTATGTICIEVPDVNDYCP-VIAAERETICI---
A-SPSILISAAGVNSHSYGSPFTFCVVNEPPGTA-DIWDIRSVNA--TSAI--LKAEQTL
YSGYYEIPVLVRDSFNRACELPQIIELR--ACDCDINHMCLSSGTTGVSTGDGSSVTS--
------------------------------------------------------------
----------------------VS----------VTDNQTEASNVGMGSTGIGMITMGVL
----LLL--LAPLLLL--------------------LCCCCKRKQPEG--LGTSFAPVPE
GG-------EGVVQS---W-RIEGAHPEDRD------VSNICVPM--T--A---------
--------------------------------SNTQDRMDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELSTGLG--AAAGLAAGG------------------------A
A--GTAGRRSS-AVGIQRDYGDT-G-------LN-LAFLDSYFS----------E---KA
YAYAGEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFKTLAEICLDTEI-DPFPS-QQ---SCIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFKEEMAI-PEPVMH-GDIVVTETYT-S
--DPCVQ---PTTIVFDPPLAPNVVVTETVMAPVYEVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVVSS-PGRADVSSSSVSDG-------
--------CRGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIRISQT-----IGSTSPVT-SRHKVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----GLLIILMVVL--E
LN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVKV MDINDNPPVFTQNV YMASIEENSDANSLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGASDGL-SSECDCRIKV L-DVNDNFPILEKTS YS--AS-IEENCLTSELMRL---QA
IDLDEEGSDNWLAKYLILSGNDGEWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NVHLSIGVKNQADFHHSV-ASQFRMQSTPVRIQVVNVREGPTFHPSSMTFSVREGK-TGD
SLLNYVLGTYTATDLDTGNPATNV-X--XXXXXXXXXXXXXXXXXXXX--XXXXXXXXXX
XXXXXXXXXXXXXX--XXX---GS-GKTATGTIYIEIPDANDYCP-VILAERRTLCT---
S-SASVLIYV---NDRSYGSPFTFCVVDEPPGTA-DLWDIRSINS--TSAI--LMTEQLL
SPGPFQIPILVKDNYNRACELPQYIQFI--ACDCDD-NLCVLSSTTGIYGEDIS------
------------------------------------------------------------
---------------LVTNNMDIY----------DDEDRLGASNVGMGXXXXXXXXXXXX
----XXX--XSPLLLL--------------------MCCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRG------SALER------------------
------------Q------------------AIQALLKPLFSEIY--------NNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLVAGG----AVG-----------------A
V--GTMRKRSS-TMGTLREYADT-G-------MN-MAFLDSYFT----------E-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-----------------------------------------------------VVVV--E
VN--SN-FQIQVRDY-NSKNGTIK-WHS------IRRHKREWIKFAAACREGEDNSKRNP
IAKINSDCSANE--QITYRISGVGIDQPPYGVFIVNPKTGDINITSI-VDRELTPFFTIY
CRALNS--RGEDVERPLELRVRV LDINDNPPVFSQTEFVG GIEENSYPNTLVMTLNATDA
DEPNNLNSKIAFKIISQEPAGAPMFILNRHTGEIRTMSNSLDRE----QQSSYSLVVQGA
DRDGASDGQ-SSQCDCRIK II-DVNDNFPYLEQSS YS--VS-IEENILNSELIRF---RA
IDLDEEFSDNWLAQFFFISGNSGNWFEIVTDSRTNEGILR-VI-----------------
---------------------------------------------------KPLNYEDAQ
SMVLSVGVRNVAEFHHSV-RSQYRVQGSSITVKVINVVEGSVFTPASKTFILQRG-----
MGANSLIGSYQAIDLDTGRPSTT-----VRYIIGSNPGDLLAVNSRTAEITFKRQVTREI
YSQVNGRYVGTILS--IDD---AA-QRTCTGTIVLDLNDVFDIND---------------
-----------------------------------------SNNS--G------------
-----------------------------------------------------GQAGGQ-
---GSSTGGGGPGGPGGPEGTATVGPSGFT-----------------DSSFQGSSTSGGS
DKDT-------------------------NTESPGYDGGRGNGKAYFGPAGIGLLILGFL
----MLL--LVPFLLM--------------------TCDCGGA---SA--VGGGFQPVPE
CT------PEGAIHS---W-AVEGPQPEDRD------ITNICVPMTT----TN-------
------------E--------------------GMDTCEENFSLQ--------EKAFSSR
ERKGPVSAASQTS--GLEMTTGVKTSVVP------------------------EVCP-GH
S--GTLLR------NSMMDYREG-G-------VN-SNFVKNYFC----------Q---KA
FAYADEDEGRPSNDCL---LIYDIEG-V--------GSSAGSIGCCSFIG-EDLDDSFLD
T-----LGPKFKRLADISMGKDV-ESFTETEH---QWTTESAEPSYPSQGP--------D
TL------------------------------------------------VNG---CPPV
PPP----------FG--TTTVVSETTY-PSGPGVQPATPI-PDPLGY-GNVTVTESYTTS
-G-MTLQ---PSAHVHDPRHGSNVVVTERVLGPMSGSD-FHGML------DVPNLRDSS-
NVIVT--------------------------ERIIAPNSRLPNTLTL-PDPRDSSNVVVT
--ERVIRPSSGLMGN-INIHPELSGAHNVIVTERVVSG-AGTTS----------------
----------GGLGGGSL-----IDTSMGGGG------------MSSG--S------MVG
TNQGGAGSGA-------GMSGSATIGHMRTS--DHFNQT-----IGSASPSA-SRSRITK
YSTLQYSK-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLAVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIISQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGV-KGN
SLLNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KHIINGIYTAEILA--IDD---GS-GKTATGTVCIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGSYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMILGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAGWWWHRR--------WRRQR
FRQ----IALQAT------------------RALFHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------VAGATGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQE-VAT-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDG-------
--------CMGPVMSDN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VGSTSPMT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MTWLLF---RTT-----GALAILMVVL--L
VH--GE-LRIETHGE-YETAXXXXX-XX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXITSDFQATQ--KITYRISGIGIDQPPFGIFVVDRNTGEINITAI-VDREETPSFQIT
CHALNA--AGQDVERPLILTVKI LDINDNAPVFSQSV FMGEIEENSAANSLVMILNATDA
DEPNHLNSKIAFKIVSQEPASTPMFLLSRHTGEVRTLTSSLDRE----QVSSYRLVVSGA
DKDGEG--L-STQCECSIKV K-DVNDNFPRFRESQ YS--AR-IEENTLSSDLLRF---QV
IDLDEEFTDNWLAVYFFTSGNEGGWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVQPGIAVRNKADFHKSV-ISQYRVQSTPLTIQV VNVREGITFRPASKTFTVQ KGI-SIR
KLVNYILGTYQAIDEDTNKAATSV-----RYALGRNDGGLLIIDSKTAQIKFAKNIDRDA
TFIVNKTITAEVLA--IDE---ST-GKTSTGTVYVRVPDFNEDCP-NIVLEKEAICS---
A-SPSVVVSARVLERDKYSGPYTFSLEEQPLKLP-VVWGITTLNX--XXXX--XXXXXXX
XXXXXXXXXXXXEGQGRQCETPDSLTEV----GQDNRDTGRNCGSTNAP-----------
------------------------------------------------------------
------------------------------R------IRGDQSSWRLGPAAIGLLLLGLL
----MLL--LAPLLLL--------------------TCDCGM-GPISG--VTGGFIPVPD
GS-------EGTIHR---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------ANGVDV-TENSXXX--------XXXXXXX
X-X--XXXX---X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X--XXXXXXXX-XXXXXXXXXXX-X-------XX-XXXXXXXXX----------X---KA
FACAEDDDGQEANDCL---LIYDNE--G----AGAPGSPIGSLGCCSFIA-DELDDSFLD
S-----LGPKFKKLAEISLGVDD-EAKISHPA---TKDSSAGIGSCGQ----SAEVQQS-
------------------------------------------------------------
---------ESVRYQAVSGSQGASALS-ASGSSLQPAISI-PDPLQQGGSYLVTETYSA-
SGS-LMQ---PSTAVFDPLLTQNVIVTERVICPISSVP---GNLHGPT------ELQASC
NKICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MAQSPGGR---------CVLLLLLICF--N
VG---SGLHLQVLNT-RNGNNLLPK-HP-----HLVRQKRAWITAPVALREGDDLSKKNP
IAKIHSDLEEEKGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALNE--RGVNIEKPLELRIKVLDINDNEPVFTQDVFFGSVEELSVANTLVMKINATDA
DEPNTLNSKISYRIVFLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKMLE--GM-VEENQVNVEVIRI---KV
FDADEVGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIIVTNKAAFHKSI-RSKYKPTSIPIK VKVKNVKEGIHFKSNVITVYV SE--SMER
SSKGQIIGKFQAFDEDTGLLA-HA-----RYVKLEDRDNWISLDSVTSEIKLAKIPDFES
RYVQNGTYTVKILA--ISE--DDL-RKTITGTIRIAVEDTNDNCP-TLTEPMQTVCN---
D-AQYVNVTAEDLDGYPNSGPFRFSVVDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGKSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------HRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQRDSLAGRNG
VG-----GMA-KEAT-VKE---------SSSGSFAKGQREMSELD--GRWEEHRSLLSVR
ATQ--VTGATGAI-ISKETTKNTRA----T-----GASRD---------VA---------
-G----AQ-------------------TAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHIAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DIDMEIEQR--QKPATE----------TSM-NTASR
SLYEQTMVNS-------------------ENT-S--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQPQKVATPL-PNPVASGNM-MATEASYAT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAHYVMVR
ERESFLAPSSGVQPT-LAMPNL-AVGQNVTMTERVL------------------------
-------APASTLQSSYLI---PTENSVKARN-----T-----MVSGA--AVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MAWLLF---RTT-----GALAILMVVL--L
VH--GE-LRIETKGQ-HGEYETAV--QG------KRRYKREWVKFARPCREEEDNSKRNP
IATITSDFKATQ--NITYHISGIGVDQPPLGIFIIDKYTGEINITAI-VDREVTPSFQIT
CRALSV--LGQEVEKPLILTVKI LDINDNAPVFSQSV LTGEIEENSASNSLVMILNATDA
DEPNHLNSIIAFKIISQEPAGTPMFLISRHTGEVHTLTSSLDRE----QVSEYHLVVSGT
DKDGEG--L-AAQCECSIKV K-DVNDNIPSFTELQ YS--AS-IKENTLSSDLLRF---QV
IDLDEEFTDNWLAEYFFTSGNDGNWFEIQTDLTTNEGILK-VV-----------------
---------------------------------------------------KSLDYEELQ
TLQLGIAVKNKAEFHKSI-ISQYTVQSTSLIIKVINMREGIVFRPASKTFTVQKGI-SGK
NLISYIVGSYQAIDEDTGKPALFV-----KYTLRRNDGGLLTIDSNTAEIKFVKNTVRDV
AVIVNKTITAEVLA--TDE---KT-GETATGTIFVRLPDFNDKCP-TIVLEKKTTCS---
S-SPSVVVTARSLE-DDYTGPYTFSQDNQIINVP--VWTITKLND--TSAT--LTTLQPV
YPGVYRISLVVTDDKGTWCKTLEDLTLE--VCLCDNNNICKTLPTTTTP-----------
------------------------------------------------------------
-----------------------------QP------V---ETPGRLGPAAIGLLFLGLL
----LLL--LAPLLLL--------------------TCYFGT-GPIGG--VSGGFMPVPD
GS-------EGAIRP---W-GIEGAQPEDKE------IANIYVP-PIT------------
-------------------------------ANRVDY-MENSEVF--------TNTCTGG
T-V--MEGA---S--GMEVTTRIGAAAGSGAAAAF------------GAAAGLSNCSAGR
S--GTMRTRHS-MEGTNMDYGEG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----KGAPGSPVGSLGCCSFIA-DEFDDSCLD
S-----LSSKFKKLAEISLGMDD-EAKNSQPP---TKESGSGIESRGQ----SVQVQQS-
------------------------------------------------------------
---------ESVRYQILPGSQGASAVS-ASGSVLQPAISI-LDPLQH-GSYLVMETSSA-
AGS-YVQ---PSTAVFDPLLT-NVIVTERVICPISSVP---GHLHGLA------ELQGSG
RKICT--------------------------ED-----------PC--------------
--SLLM------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRPC---------VLLLLLICF--N
FG---NGLHFEALNT-RNENQLLPK-HA-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERGLKITYKYTGKGITEPPFGIFVFNPSTGELNVTSI-LDREETPYFLLM
GYALDE--KGNNLEKPLELRIKVLDINDNEPVFTQEVFTGSVEELSAAHTLVMKITAIDA
DEPNTMNSKVSYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYSLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVTENEM YE--GT-IEENQVNVEVMRI---KV
TDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEQMK
NLDFSIIVTNKAAFHKSI-RNKYKPTSIPIK VKVKNVKEGIHFRSSTISFRASE--GMDK
S SQGLLIGKFQVFDEDTGQPA-QV-----KYAKLEDKDNWVSVDPVTSEIKLVKIPDFES
RYVQNGTYTVKIMA--ISD--EYP-RRTITGTVLITVEDINDNCP-TLVDPVQNICE---
N-VPFVNVTAEDLDGYLHSEPFSFSIIDEPPGMA-EKWKIIRQES--TSVL---LQQSEQ
KLGRSEIQFLISDSQGLSCPEKQILKLT--VCECLHGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAVALMILALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPTLLAV-----DHAENSAVRNG
IG-----GTMAKEAT-MKG---------SSSASFTKAQHNLSAMD--GRWEEHRSLLSSG
ATQ--IMGTTGGMVGGAETMRTTRA----T-----GASGN---------MA---------
-G----ARA------------------G-AVAVN-EEYLRNYFT----------E---KV
ASYTEEDDVHMAKDCL---LVYSQEE-T--------ASPHGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DMDMEIEQR--QKPVKD----------TNM-NTAPQ
SLYDQTVVNS-------------------ETSYS--SGNSFQ-----------------V
PKS--LHE---ANAEKVTQEVVTERSV-SSRQGQKVAPPL-AEPLPSGNI-IMTETSYAT
-GSSIP----PSTVILGPRQPQNLIVTERVYAPASTLV-------------DQH-YANEG
SVMVT--------------------------ERVIQPNGGVPNPLEGTQHLQDAQYVMVR
ERERVLAPSSGVQST-LVVPNV-AVGQNVTVTERVL------------------------
-------TPASTLQSSHQI---PIETSMKARN-----V-----VVSGA--GVSDPLSNF-
--------------------GLEETGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
-----------------------------------MSR-----GSAAARLLALLICL--S
CG---NGLHWKIHNRSG-RSGTLFH-PN-----SLVRQKREWTVPPAFIREEEDNSYRNP
IARIHSDF-EDTGIVVTYTISGQGVTEPPYGLFVINGKTGYLNVTGR-VDREKTPVLFLR
GHALDR--TGAKLEEPIDLPVRVLDINDNPPVFSHEVFVGSVEELSETGTIVMRLNATDA
DEPNNLNSKIAFKIISQSPS--SAFSMNKDTGEVQVATINLDRE----TQSSYSLVVEGK
DRGGAADGN-GATCSVEI KIL-DVNDNLPVLESSAFE--GS-VEENRANVEILRI---KV
FDKDEEFSDNWLANFSFVSGNEGGYFRIVTDTRTNEGILT-LV-----------------
---------------------------------------------------KALNYEEMQ
SLNLGIVVTNKAEFHKSI-KSSYKAQTIPIRIH VIDVREGPVFPGGTKI IEASES-----
VRVNQVIGQYQAIDEDTGKAAVHI-----KYIKGRDPANWIIINSNTAEIQLAKNLDYES
SYVVNGTYTFTMLG--VTT--DLP-TKTVTGTVVIHIQDENDNCP-IIENPVQTVCS---
D-ARFVDVTAKDIDSYPYSAPYSFSVIDEPKGTA-EKWIIASRNA--TSVR---LVPQNL
KAGSATVPLLIKDFQGFSCAQPQSLQLF--VCTCTADGGCKDR-I---------------
------------------------------------------------------------
---------------------------------------IGTGSVVLGPAAIALIILALL
----FLL--LIPLLLL--------------------LCPCGSGAK-------KGFATIPD
CS-------EETLRK---W-NSEGAVPEEKS------MQSVMLPTALGNLKGAAAITAA-
----AAAAGMSAEEA--------AA-GGSSSASNIRGQS-NTITS--EVWEEQRHLLPTA
DYH--TRSIA---TGRAEGMI---------------------------------------
-S----GEGN--V-VTGG--G---VAMESTGAMN-EEFLRDYFT----------D---KA
VSFAEEDEAQAARDCL---LVYSQGE-S--------GSPHSSIGCCSFIE-GDLDDHFLD
D-----LGDKFKTLAEICIGRRI-DMKD---------------ASSKNESSFGVN-----
---EQKAFSS-------------------KQTSA--SGGYLS-----------------H
TPS--VQAGGAVGSEAVSQEVIMETTS-SLQSGQHDARTL-TTP-FTETNVTMT-ETYSG
-GGPTC----SAASFLDPQFKENIVVTERVLAPASGLR---EMV------EIPS-LPSGK
NMVVT--------------------------ERMLTSEGPGVGTMA-VQDLPNSKYVVVR
ERERVLVPSTE-QGS-LSFPTL-SEGQSMVVNENDLTA-SAGPG----------------
----------------------------RAEQ-----VLITDSLLSQSGSAMEGAPP---
----------------------------------------------AS-STLSKSSRVTK
YSTVQYSRS----------------

------------------------------------------------------------
------------------------------TMGLLP---RTS-----GALAILMVVI--L
VH--GE-LHIETKGQ-HDEDRTAVQ-QT------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDQNTGDINITAI-VDREETPSFLIT
CRALNA--LGQDVEKPLILTVKI LDVNDNPPVFSQSIFM GEIEENSASNTLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEIRTLTNSLDRE----QVSSYRLVVSGA
DKDGEG--L-ATQCECSIK VK-DVNDNFPVLTDSQ YS--AH-IEENTLSSDLLRF---QV
TDWDEEYTDNWLAEYFFTSGNEGNWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
TLQFGIAVKNKAEFHQSV-ISKYRVQSTPVTIQ IINVKEGITFRPASKTFTVQKGI-SSK
KLVNYVVGTYQAIDEDTNKAASHV-----RYIMGRNDGGFLMIDPKTAQIKFVKNLDRDS
TFIVNKTITAEVLA--IDE---TT-GKTSTGTIHVEVPNFNENCP-TIVLEKQEICS---
S-LPFVVVSARALNNVKYTGPYTISLEEQPQKLP-AVWSITTLNG--TSAL--LKAQQQV
SPGVYRISLVITDSQNNQCETPESLTLE--VCQCDNRDTCGTYDPNRDP-----------
------------------------------------------------------------
-----------------------------GA------KYGQPASGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGTTGPTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------ANGVDF-MESSDIC--------THTYAGG
T-V--VEGA---S--GMELTTKVGATTGSGGAAGFAAGTVCGAAGGFGAANGLGICPVGQ
S--GTMRTRHS-TGGTNRDYADG-P-------IN-MNFLDSYFS----------Q---KA
SAWAEEDNGPESNDCL---LIYDNE--G----TDASGSPVGSLDCCSFIT-DDLDDSFLE
S-----LGPKFKTLAEIILSVDH-EAKQAQQS---AKESGYGVESCGR----TTEVPQP-
------------------------------------------------------------
---------GHGRHQTLSGSEGAPALS-ASWS-IQPAISI-PDPLQH-GNYMVTETYSA-
SGS-LVP---PSAVVFDPLLTQNVTVTERVICPISSVP---GNLAGPT------QLRGSR
TVLCT--------------------------ED-----------LC--------------
--SRVI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
---------------------------MASSKLCRFM---LM-----WYLLLKQVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESSQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGI-KGS
SLM NYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGSYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---SAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAP-------MT-------
-------------------------------ASNTQDRMDSSEIY--------TNTYVAG
GTV--EGGV---S--GVELNTGMG--TAAGAA--G----VA-----------------GA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANTLVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSAMAFSVREGI-KGS
SLLN YVLGTYTAIDLDTGNPATDV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDEPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAYALPGGGG--TADG-GG-SV
LGR----CALQAT------------------PALLNQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAVGLMAAG----AA-----------------GA
S--GAARKRSS-TMGTLRDYADA-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DQCMQ---PTTIIFDPQLAPNVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWRF--FRGA------AVLFIFL------
-----------VRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMERSS YD--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVLQGKR------------
----------TILS--IDD---D---------------------R---------------
-----------------------------------------T-----N------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TSDIT
----ILPPPVVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWHSFR--RA------ALLLAFLVVL--E
VN--SE-FQIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTFL GQIEENSNANTLVMKLNATDA
DEPNNLNSLIAFKIVRQEPSEAPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAECECSISI L-DVNDNIPYLDQSS YD--IK-IEENALHSNLQQF---RV
IDLDEEYSDNWKAVIFFVTGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAMQ
KLQLSIGVRNVAEFHQSI-LSQYTLTVTMITVKVLNVVEGSVFRPGSKTFVVHSR-----
MDANYRVGEFTATDLDTGMTS-----TNVRYVMGNNPEGLLVVDSKTGIITLRNRVTMEQ
YQRLNGRYEGTMLS--IDD---SL-QRTCTGTIIIELDGTGWETG---------------
-----------------------------------------GGGG--G------------
-----------------------------------------------------GGGGGGD
GGGGGDGGGGGGSGSGGD------------------------GG---GGDGGGQ-VTNGY
KDT-STEEP---------QRT-----TLTRDIDNTDTYQADEDNVHLGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GITTICVPQMP----PG-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELVDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPTGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPDP---SWPPQSTEPICPQR-T--------E
PL------------------------------------------------ASG---HPPI
SPH----------FG--TTTVISENTY-PSGPGIQHPMQI-PDPLGY-GNVTVRESYTTS
-G--TLK---PSVHFHDNRQASNVVVTERVVGPISGAD-LHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNPLETSNVVVT
--ERVIQPTSGMIGN-LSMPPELSSAHNVIVTERVVSG-AGVSGVTGTAGIG--------
--------GVGGIGT-----------------------------MSAG--GVGDGGTG--
---------M-------SMGGTATIGHMRSSSDHHFSQA-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------------------------LLATSTVFL--D
IS--AG-FHVEV-KE-WNENNVTR-WKT------FKRQKREWIEFAAACREGEDNSKRNP
IAKIRSDCEENQ--PIVYSISGIGIDQPPYGIFVINKNTGEINITSI-VDREVTPMFVIR
CYARHA-IT NREVEPPLDLRIRVLDINDNAPVFSQATY MGSIEESSMETTLVMKLIATDA
DEPNNLNSKIAYKIVSQEPAGASMFILNRDSGEVH-IANYLDRE----QYDRYSLVVRAS
DRDGAADGI-SSQCTCSIE VI-DVNDNFPTLLQNS YS--AS-IEENTLSSQLLMI---QA
IDRDQMFSDNWLAEFYFI-GNEDNCFEFVTDSTNNVGILK-VI-----------------
---------------------------------------------------KPLNYEQMQ
SLQLSFAVRNKAAFHHSI-ASQYQVIGTPLTIQVINVKEPPSFQPSTRIFYIPRDL-SKE
AMSNYIVGMCAATDEETGLIASNV-----RYLMGYDPSSMFKINAKTGELRLNK-FDWSM
LNVGKGFYKAEILA-ITEG---IP-ANTATGTIVLTIQDDNDNCP-VLSTDIRKICM---
S-APSTVLSAQAD---------------QPPK---GSWTLRPIDGKTAVST--GV-----
--Y----------------------------------------------VGDGTPDV---
--------------------------------------------------GRWPG-----
-----------------------------------R-----GGTTTLGGGAIALMFLGAL
----IFL--LVPILMAM--------------SACCDRCGYKA-RPVGG--VGAGFEPVPE
CD-------GGAIHS---W-GIEGAHPQDQD------VTSISVTKHAG------------
-------------------------------SAGEIVESSVSGIY--------TNTRGGT
A-I--NTGM---K--ETS---GL------ETAVDYGRFPIYGTTS-------------G-
------YRKESV-GGTLQEYREG-G-------VN-MAFLDSYFA----------E---KA
FAYADEDEGRPANDCL---LIYDHEG-I--------GSPVGSIGCCSFIG-EDMDDTYLD
T-----LGPKFKTLAEICLGKVV-EPIPGVSA----------------------TFPNID
SDLKLPPPGT-------------------------------------TIIVNES---SSM
PPQ----------VGS--TTFVTENTY-ASGATLQPARPI-PDPLLH-GNVMVTETYTSG
--S-TFQ---PPALTIDPLRASNVVVTERVLAPN--SD-LRGVL------NIPDLTDGA-
NVVVT--------------------------ERVIAPGSRLPPSLSI-PDLADGSNVVVT
--ERVIRPASGLQGS-LNIPSELSNAHNVVVTERVLSG-PGVSGMGGM------------
------------------------------------------------------------
---------------------SSMTGQM-LSADSHFNQT-----FGSASPGT-SRRRVTK
YSTIQYAN-----------------

------------------------------------------------------------
------------------------------MAGSLF---RTT-----GALTILLXXX--X
XX--XX-XXXXXXXX-XXXXXXXXX-XX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXISSDIQATQ--KVFYRISGMGADQPPLGIFIVDKNTGEINITSI-VDREETPS FQXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXTLVMILNATDA
DEPNHLNSKIAFKIISQEPSATPMFLISRHTGEVHTLTSSLDRE----QISSYHLVVSGA
DRDGEG--L-SSQCECSIKV K-DVNDNFPVFKESQ YF--AR-IEENTLNSELLRF---QV
TDWDEEFTDNWLAEYFFTSGNEGNWFEIQTDSRTNEGILR-VV-----------------
---------------------------------------------------KALDYEQLQ
KLQLGIAVKNKAEFHHSV-ISQYRVHSTPVTIQV INVKEGIKFNPPYKT FTVQKGI-SSK
KLMNYILGMYQAFDEDTGKASSSV-----RYVMGRNDGGLLTIDPKTAQIKFIKNIDRDS
TFIVNKTITAEVLA--IDE---NT-GRTSTGTIYVKVPGFSENCP-TIFFEKEVICS---
S-SPSVIVSTKVQDRDKYTGPYTFSLEEQPVKLP-VVWSITTLNA--TSAL--IRAQQQI
SPGSYKIPLVVTDSQGQLCDMPETLSLE--VCQCDDRDICGTTYPKER------------
------------------------------------------------------------
-----------------------------EP------LYEKKSWVGLGPAAIGLIFLGLL
----MLL--LVPLLLL--------------------TCDCGT-KPIGG--GIGGFVPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PVM------------
-------------------------------TNGADF-MDSSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTKLGAANGSAATGAF----------------GTAICSAGL
S--GTMRTRHS-TGGSNRDYAEG-A-------IS-MNFLNSYFS----------Q---KA
LACAEEDDGQEANDCL---LIYDDE--G----MGVPSSPVGSLGCCSFIA-DDMDDSFLD
S-----LGPKFKKLAEISLGVGANEVKLSQQP---TTGSGSGIEVCSH----SVGTQQL-
------------------------------------------------------------
---------GSARYQTQSGSQGATTLS-TCGPNLQPAISI-PDPLQS-GSFLVTDTCMA-
SGS-LMQ---PATAVFDPLITQNVIVRERVICPVANVP---SNVVGST------EIQGSC
NIICP--------------------------PD-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRPCA---------LLLLLICF--N
FG---NGLHFEALNT-RNENKLLAK-HT-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERGIKVTYRYTGKGITEPPFGVFVFNKDTGELNVTSI-LDREETPFFLLV
GYALDE--KGKNLEKPIELRVRVLDINDNEPMFTQDVFVGSIEELSAAHTLVMKINATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIFTTSITLDRE----EHSSYSLTVEAR
DGDGKVTDKPAKQAQVQIR IL-DVNDNIPVVESEMLE--GL-VEENQVNVEVMRI---KV
FDADEVGSDNWLANFTFASGNEGGYFHIETDAQTNEGILT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIIVTNKAAFHKSI-RNKYKPTSIPIK VKVQNVKEGIHFKSSTISVHASE--STDI
S RRGQVLGKFQAFDEDTGQPA-RV-----KYAKLEDMDNWVSVDSVTSEIKLAKIPDFES
RYVQNGTYTVKIIA--ISE--DYP-RKTVTGTVRIMVEDINDNCP-TLVDPVQTICD---
D-VPYVNVTAEDLDGYPNSGPFSFSVIDQPPGMA-EKWKIVRQES--TSVL---LQQSEQ
KLGRSEIQFLISDNQGLSCPEKQTLTLT--VCECLDGSGCAKA-----------------
------------------------------------------------------------
---------------------------------------LRSSYVGLGPAAIALMILALL
----LLL--LVPFLLL--------------------MCHCGEEAK--GF------AAIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VLPLLAV-----DQRDGLAVRNG
VV-----GIT-REAT-VKG---------SSSASFTKVQQEMSEME--GRWEEQRSLLTSG
AAQ--VTGTAGAI-TSAASIRTTQA----T-----GASRD---------MA---------
-G----ASRD--MAGASRDMV---GARVAAGALN-EEFLRSYFT----------D---KA
ASYAENDEIHTAKDCL---LVYSQEE-T--------ESLHGSLGCCSFIE-GEQDDRFLD
D-----LGLKFKTLAEVCIGQKI-DTDMQIEQR--QKPVAG----------TGT-KAASR
TLYEQTKVDS-------------------ENTYA--SGSSFQ-----------------V
PKS--LQE---TNAEKVTQEIVTERSV-SSRQAQKVATPL-PDPLASSNI-IVTETSYAT
-GSTMP----PSTVILGPTQPQSLIVTERVYAPASTLV-------------DQH-YANEG
KVMVT--------------------------ERIIQPNGGVSNPLEGTPPLQDTQYIMVR
ERESFLAPSSSVQPT-LAMPNV-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PAEDSVTARK-----T-----LVPG-------ALPTF-
--------------------GLAESGHSNS-------------------TMTTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------------------------------------
-----------ALNT-RSENKQPPK-HT-----HLVRQKRAWITAPVTLREGEDLSRKNP
IAKLHSDIAEERGIKITYKYTGSGITEPPFGVFVFNKDTGELNVTAI-LDREETPIFLLI
GYAIDE--KGNNVEKPLELRIKV LDINDNEPVFTQDV FVGSVEELSAAYTLVMKINATDA
DEPNTPNSKISYRLVSQEPAYPAVFYLNKDTGEIYT-SFPLDRE----XXXXXXXXXXXX
XXXGQITDKPVKQAQVQIRI L-DVNDNIPVVENEM YE--GM-IQENQANVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAKTNEGIVT-LI-----------------
---------------------------------------------------KELYYEEKK
NLDFSIVVTNKAAFHKSV-KNKYKPKSIPIKVKV QNVKEGIYFKSST ISVHVSE--SLDI
SSQSRIIGKFQAFDEDTGRLA-HV-----KYAKVEDIDNWISVDSVTSEIKLVKIPDSES
RYVRNGTYTSKIVA--ISE--DYP-RKTVTGTIVIKVEDINDNCP-TLVNPVQTVCH---
D-APYVNVTAEDLDGFPNSEPFTFSVIDIPPGMA-EKWKILHKES--KSVL---LQRKER
MLERSDIHFLITDSQ-LSCREQQVLRLT--VCECLAGGGCVQA-----------------
------------------------------------------------------------
---------------------------------------LHNSYVGLGPAAIALIIFALL
----LLL--XXXXXXX--------------------XXXXXEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLGG-----TYRENPAVGNG
VG-----GTITKETT-VKG---------DSSAFLTKGQHEMSEVD--GRWEEHRSLLTHG
VAQ--VTGTSGVV-MGAENRRTIGA----T-----GAARE---------VA---------
-G----AQ-------------------AAAAAVN-EEFLRSYFT----------D---KV
ATYTEDVDVHTAKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GELDDHFLD
D-----LGFKFKTLAEVCLSQKI-DMGIEIEQW--QKPVTE----------TSR-ITDSR
SFREQTMDNT-------------------ENTYL--SGSSFE-----------------V
LKP--LHE---VNTEKVTQEIVTEQSV-SSRQGQKVAKPL-PDPLAPGHF-IVTETSYAT
-GPTRP----PSTLVLGSREPQGLIVTERVYAPASALV-------------DEP-DANES
HVVIT--------------------------GREMQPPGGTAHLLGGPQHLADAHYVMVR
ERECILAPSSAVQPT-AVMSSV-AVRQNVTVTERVL------------------------
-------TPASTLHSSYQI---PVETSMIAGK-----T-----IGSGA--GVPGP-PDF-
--------------------GVEASGGSNS-------------------AITTSATRITK
HSTV---------------------

------------------------------------------------------------
------------------------------MAASPGFS--------VFFPVLLMICF--N
FG---NGLHFEALNI-RNENKLLSK-HT-----HLGRQKRSWITASVTLREGEDLSRKNP
IAKIHSDVAEERGLKITYRYAGQGITEPPFGIFTFNKDTGELNVTSI-LDREETPIFMLI
GYALDE--KGNNVEKPLDLRIKVLDINDNEPVFTQDVFVGSIEELSAVDTLVMKISATDA
DEPNTPNSKISYKIVSQEPSYPPVFHVKKDTGEIYA-SITLDRE----EHSSYTLTVEAT
DGNGQITNKPVKQAQVQIHV L-DVNDNIPEVENEM YE--GM-IQENQANVEVMRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAKTNEGIVT-LI-----------------
---------------------------------------------------KEVNYEEMK
NLDFSIVVTNKAAFHKSV-KNKYKPVSIPIK VKVQNVKEGIHFKSSTVSVHVHESLSLDK
S SQGQIIGKFQAFDEDTGQLA-RV-----KYTKLEDIDNWISVDSFTSEIKLIKIPDFES
RYVRNGTYTSKIMA--VSE--DHP-RKTITGTIVITVEDINDNCP-TLVNPVQVVCH---
D-APYVNVTAKDLDGPQNGEPFMFSVIDKPPGMV-NNWKILHQES--TSVL---LQQNER
KLGRSEIHFLITDNHGFSCPENQILRLT--VCECLDGSGCVAA-----------------
------------------------------------------------------------
---------------------------------------LHDASVGLGPAAIALIIFALL
----LLL--LLPLLLL--------------------TCHSGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVG-----VQGKNSAVGNG
TG-----GPMTRKAT-EKE---------GSSDSFTREQHKLSEVD--GRWEEHRRLLLHE
ANQ--RTGTTGAI-TG-TETRTTRD----T-----GTTRD---------LT---------
-R----AR-------------------AAAAAED-EEILGSYFT----------K---KA
AAFTEDDDFHTAKDCL---LIYAQEE-T--------PSPHGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DTDRKIEQW--QKPVTD----------RSV-NTAPR
SLHEQTMFNS-------------------ENTYS--SGSSFQ-----------------V
SKP--LHD---VNAEKVTQEIVTEQSA-SSRHSQKVATPL-PDPLPASNRVTVSETHYAP
-SPARP----PSAVVLGSRQPQGLIVTERVFAPASALG-------------DQH-YGNEC
NVVVT--------------------------ERVMQTPGGTANPLEGPHHLPDEHYVMVR
EREHVLVPSSGVQPT-LVVPSI-AASQNVTVTERVL------------------------
-------APASSLQSSYQI---PAETSMTARQ-----T-----VLSGA--GVPSPSPDF-
--------------------SLETSGGSSS-------------------AVTTSSTRITK
HSTVQRSFS----------------

------------------------------------------------------------
------------------------------MAWLPF---RTT-----GALAILMVVL--L
VH--GE-LRIQTKGQ-YEEYETAI--QG------KRRYKREWVKFARPCREGEDNSNRNP
IAKITSDFEATQ--KITYHISGIGIDQPPFGIFVVDRNTGEINITAI-VDREVTPSFQIT
CRALNA--LGQDVEKPLILTVKI LDINDNAPVFSQSIF QGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTSMFLLSRHTGEVRTLTNSLDRE----QVSSYRLVVSGA
DRDGEG--L-SSQCECSIK VK-DVNDNFPTFRESQ YL--AR-IEENTLSSELLRI---QV
IDLDEEFTDNWLADFFFTSGNEGHWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KSLDYEQVQ
SMQLGIAVKNKAEFHQSV-ISQYQVQSTPLIVQVINVREGIAFRPSSKTFTVRKGI-SSR
QLINYVLGTYQAIDEDTGEVASFV-----RYVLGRNDGGLLMIDSETAGIKFVKNIDRDV
TFIVNKTITAEVLA--IDG---NT-GKTSTGTIFVLVPDFNEKCP-TIALEKEAVCS---
S-SPSVVVRASPLERDKYAGPYEFSVEHQSLKLP-VVWSISGRDA--TSAL--LTAPQPV
SPGVYRISVMVTDSEGRRCEEPESLTLE--VCQCDYRDICPNVYPTSIP-----------
------------------------------------------------------------
-----------------------------NP------IIGE-RSGRMGAAAIGLLFLGLL
----LLL--LALLLLL--------------------TCDCGA-GPIGG--VTGGFVPVPD
GS-------EGTIHP---W-GIEGAQPEDKE------ITNIGVP-PIT------------
-------------------------------ANGVDF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTNLGAAAGSGGAAGFGA------------TAGLSNFSVGQ
S--GTMRTRHS-TGGTNKDFGEG-A-------IN-MKFLDSYFS----------Q---KA
FACADEDDSQEANDCL---LVYDNE--G----IEAPSSPVGSLGCCSFIA-DDFDESFLD
S-----LGPKFKKLAEISLGMDD-ETKSSQPP---TKDSSSRVDACGQ----HVQVQQS-
------------------------------------------------------------
---------ESVRYQTLSGSQGASALS-ASSSVLQPAVSI-TDPLQH-GSYLVTETYSAS
SGS-LVQ---PPAAVFDPLLTQNVIVTERVICPTPSIT---GNLHGPT------ELRGSD
SKIFT--------------------------ED-----------PS--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLLLLMVVL--G
VN--SE-FIVEVKEL-DVENGTTS-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYSILSGNDGNWFEIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KTLDYEELP
NIYLSIGVRNKAEFHHSV-ASQFQMHSTPVRIQ VVNVREGPIFRPSSMTFSLREGV-RGD
SLM NYVLGTYTAIDTDTGNPATNV-----RYTIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGIYAAEILA--IDD---GS-GRTATGTICIEVPDANDYCP-VIYAERRSVCV---
D-ASSVRIYV---SDHSFGSPFTFCVVDESSDAA-NIWNIRSINE--TSAI--LMTEQTL
SPGLHQIPILVTDSHNRACELPQTVLLD--ACFCDEGQVCLHSSTTGIYSGDP------T
------------------------------------------------------------
---------------WVTDDTYG------------TDDGVGQSNVRLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------IC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGM---S--GGELNTAIG--TTAGLVAGG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGVT-LSEAEFQAEMEAASEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVYYAERVVAS-PGVPDMGNSNMTDA-------
--------CMGPMVSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGANSPMTTSQHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLNSELIRL---QA
IDLDEEGTDNWLAKFLILSGNDGNWFDIQTDPQTNEGILK-VVK----------------
----------------------------------------------------MLDYEQTP
NIHLGIGVKNQAEFHHSV-ASRFQMHSTPVRIQ VVNVREGPTFHPNSRTFSIREGI-RGN
SLLNYVLGTYTATDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-RRTATGTICIEVPDVTDYCP-VVLAESHYICI---
A-SPSTLISARDVGDHSYGSPYTFCVVDQPPGTA-DMWDMEPVNA--TSAI--LTAVQPL
DQIVYQIPIIVKDSYHRTCELPQIVALE--ACDCDNNHVCLYPSTTGFDVGDG------S
------------------------------------------------------------
---------------SATSDIDGT----------ITDEQAGGSNVGLGPTGMGMIAMGLL
----LLL--LSPLLLL--------------------MCCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICVPM--T-----A------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAVGLAAGE------------------------A
A--GARRRRSS-TIGTQWEYADA-G-------LN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNDSSGMT-LSEAEFQAEMAI-PEPMIH-GDIVVTETYTTA
--DQCMQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYTERVLSS-PGMPDMSSGSMTDG-------
--------CMGPVMSSG---------------------------------ILVAPEIQVT
Q---------MM-----------------S-PNIHISQT-----TGSTSPMT-SRHRV-R
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWHSVR--TA------AVLLIFLVVV--E
VN--SE-FRVQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQAPFGIFIINPKTGEINITSI-VDREVTPFFIIY
CRALNP--QGQDLERPLELRVK VMDINDNPPVFSMSTFL GEIEENCNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNSFLDRE----LYSQYALAVRGS
DRDGGADGM-SAECECSIKV L-DVNDNIPYLQESS YS--VE-IQENTLYSDILQI---TV
IDLDEEFSDNWMGVIFFVSGNEGGWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEEMK
NLQLSMGVRNKAEFHSSI-RSQYKLTATAISVKINNMIEGSVFRPGSKTFVVTSN-----
MGQNYRLGDFVATDLDTMLPSTT---VRHRYVMETNPADLLAIDSRTGVITLRNKVTRQQ
YAMLNGQYKGTVLS--IDD---AL-QKTCTGTIIIDLEGNGWNGE---------------
-----------------------------------------GTTN--G------------
-----------------------------------------------------GTSTGST
NGNGGTGTGTGTGTGTGTGFNG------NRD--ST-------------TSNYDVT---G-
-----------------STAG-----PFQAVSTMDTPLGMPVDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--VGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPELRD-----MT-TIGVPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEFCGG
EMH-ELAGGGVTS--GYELTTGVKGPGVP------------------------EICQ-EY
S--G----------NSMKEGREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDTFLD
T-----LGPKFKKLADITLGKEV-ESYPNFDP---SWPSETIEPVCPQQGT--------E
----------------------------------------------------------PI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-PDPLGF-GDVTVKESYTTS
-G--TLM---PSVHVHDNRHASNVVVTERVVGPISGTD-LHGIL------DMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-PNSRESSNVVVT
--ERVIRPTPGMTGT-LSMHPDLSSAHNVIVTERVVSG-SGITGISGTAGMS--------
--------GGSGLGTGGL-----VSTGIGAGG----------GGLSGA--GVSGGGVGLS
SLSAGGGLSG-------GIGGTATIGHVRNSSDHHFSQP-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MTCLFP---RAL-----GPLVLLMV-L--L
VH--GE-LRTESGGQ-HREDGTAVQPVV------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLILTVKI LDVNDNAPIFSQTIF KGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMPMFLISRNTGEVRTLTSSLDRE----QISSYHLVVSGT
DNDGTG--L-STQCECSIK VK-DVNDNFPVLRDSQ YS--AR-IEENTLNAELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
SLQFSIAVRNKAEFHQSV-ISQYRVQPTPVIIQV TNVQEGISFRPPSKTFTVPGSI-ST S
KLAGYILGTYEATDEDTGRAASTV-----RYVLGRNDGGLLVIDPKTAQIKFIKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVHVEVPSFSENCP-SVVLEKNEICS---
SASPSVLVSVRTLERGRYTGPYTMSLEEQPLKLP-VMWNIRMMND--TSAL--LRAQQQV
PPGVYSVPVVVKDNEGGQCDTPEILTLT--VCQCDDRNMCRAPNPSREP-----------
------------------------------------------------------------
-----------------------------MR--------HRESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------ACDCGS-GPIGGGAATGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V--VEGA---S--GMEMTTKVGAATGAGA------------------AGTLGPCSLGH
S--GTMRTRHS-TGGTLKDYVVA-P-------VN-MTFLGSYFN----------Q---KS
FAYAEEEDEREVNDCL---LIYDDED-E----DGAPCSP--ALSSCSFIP-DDLDDSFLE
S-----LGPKFKKLAEICLGIDD-EAKQAKPG---PKDSGSGAGICAR----SAEVPQSG
ANRYQTLPGSLEIPQSRSQRHQT-------------------------------------
----------------LPGSQDASVLF-TSGS-VHPAIAI-PDPLQL-GNYLLTETHTT-
SGS-LVQ---PTTATSDSHLTQNVTVTERVICPLPSIS---SSIVAPT------ELRGSY
SMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MNWPFFG--AA------VVLLIFLVVL--E
VN--SD-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLEKPLELRVRV LDINDNPPVFSMSTF VGEIEENSNANTLVMVLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYIELPTQS--IS-IEENTLNSNLLQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDFEAMN
NLQLSLGVRNKAEFHQSI-MSQYKLTATAVSVTVLNVIEGSVFRPGSRTFVINSN-----
MGQNYKVGDYVALDLDTGRPSTT---VRNRYVMGRNPTDLLAIDSKTAAITLRNKVTMEQ
YKILGGKYEGTILS--IDD---AL-QRTCTGTIVINLENGGWETD---------------
-----------------------------------------RTNL--N------------
-----------------------------------------------------GSTTTEY
GLTSR---HVATNGYTT-GVG-----------------------ID-KNTYAGD------
-------T-------------------NGNVGEQPGVYQPLGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDYGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGAQADPGA-----LT-NIGVPCIP----GT-------
------------N-------------------ANVIEYVDNSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTDGVKMSGGP------------------------EICQ-EY
P--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDV-EPFPDSDP---SWPPDSTEPVCPPQGT--------E
PT------------------------------------------------GGG---HPPI
SPR----------FG--TTTVISENTY-PSGPGVQHPTPI-PDPLGY-GNVTVTESYTSS
-G--TLK---PAVHIHDNRHASNVVVTERVVGPISGAD-LQGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTTLTI-PDPRQSSNVVVT
--ERVIQPTSGIVGN-LSMHPELSNTHNVIVTERVVSG-SGITGSSSLLG----------
---------------------------------------------SAS--GGSGGGIGLG
SLGGGAGLSS-------SLGGTATIGHLRGSSEHHFSNT-----LGSASPTT-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLPHRTAAF--------LFLLLVLL--D
FS--TG-FHVEV-KE-WDENGMAR-WKT------FRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEEDN--PITYSISGVGIDRAPYGIFVVNPRTGEINITSI-VDREVTPVFVIR
CFAKHS-VTGIDLEPPLELRVRVLDINDNPPVFAQTVFTGSVEESSMDNTLVMKIIATDA
DEPNHLNSKIAFKIESQEPSGPPMFIMNKYTGELH-LANYLDRE----QHSSYTLVVKAS
DRDGAADGI-SSLCSCNVK VI-DVNDNFPTLAQSS FS--AS-ISENSLSSELLRI---QA
LDADEEFTDNWLAEFFFISGNEDNCFEIVTDRATNQGILR-VI-----------------
---------------------------------------------------KELDFEHIR
THSLMIGVR NVAAFHHSV-AHEYQIFGTPLTVEVKNLIEPPRFHPSSVV FTLAEG-----
ARVNYVVGTYTAMDEDTRTIATNV-----VYSIGRDPAAWFRINQNTGEITLNKVINRDS
VYVVNGQYQAEVLA-ITRG---VP-RYTATGTIVLSIDGINANCP-SINTEMRKVCM---
H-SPSVIISAKPRDGVLYATPFTFSIHG-EPQ---TTWIIRRIND--SSAE--LV-GQNI
DFYLYRIYVVVRDSQGRRCARPHIIPVQ--ACQCDSRNYCTSGATRIIIIGGGGSGGGTA
GGGGGSTGGGGR------EEGGQQGG-----GDYD---ETRPGGGDFEDHTDWQGYTDGY
------------DGGEE---GYTASTDEGYGNENYG--RQYESNTTLSGAAIGLMFLGGL
----IFV--LIP-----IL----------MSMSDCC--GCGP-GAAGG--VGTGFEPVPE
CT-------EGAIHP---W-GIEGAQPEDRD------VSHILAPTTAA------------
-------------------------------GGDFGEPS---DIY--------NNTYGGG
G-V--VA-----S--GVE----E------TTGVGYGTGTGYGTAG-------------GI
S--GTGEAKGSI-GGTIKEYREG-G-------VN-MAFLDNYFS----------E---KA
FVYADEDEGRPANDCL---LIYDHEG-V--------GTPVGSVGCCSFIG-EDTDETYLD
T-----LGPKFKTLAEICLGKEI-EPFPDANP---PWPGIVN-----------IPFPSPE
SDLNLPPPGT-------------------------------------TIVVNGS---APM
PPP----------AGTT-TTVVTENTY-TSGATIQPPRPM-PDPLLH-GNMTVTETYTSG
--S--------PSLCVDPLRASNVVVTERVVGPASASE-LRGML------DIPDLTEGS-
NVIVT--------------------------ERVIAPNSRLPASLSI-PDLVDGSNVVVT
--ERVFRPASGMPGSLINIPAELSNAHNVVVTERVVSG-SGMSSLGGT------------
--------------SLG-------------------------------------------
---------------GANLGGLSSTGQM-LSADCHLGQG-----MGTASPGT-SRRRVTK
YSTVQYSSQ----------------

------------------------------------------------------------
----------------------------MAW-----LP-----GLGTPGVLLLLSCI--I
FG---NGLHLEIL--GG-KNDELFN-KN-----SLIRQKREWVVPPAVIWEERDNSKKNP
IAKIRSDRSVEPGVIITYTISGQGVTEPPYGLFVINGKTGDLNITGI-VDREQTPMLHLK
GYALDQ--NGVNLEKPLDLRIKV LDINDNSPVFSQEV FSGSIEELSAIGTLVMKITATDA
DEPNTPNSLIHYRIISQEPNQPQAFVIKPETGEVRTALIQLDRE----MQSSYTLIVEAK
DGNGSLAGN-AQQTSLQIK IL-DVNDNIPVLEKDN YV--GS-VKENTANMEIMRL---KV
FDRDEEFSDNWLAQFTILSGNEGGYFQIETDSQTNEGVLK-LV-----------------
---------------------------------------------------KEISYEDLK
SADLNIVVSNKA AYHQSIIKQGFQAKPIPIKINVENVVEGPVFKPQTMVIKG NEK-----
MTIGQIIGRFQAHDEDTGTIAKNV-----RYAKDRDAANWFVIDSKTAEIKLIRVPGYES
QFVNNGTYTATILA--ISD--GIP-SQTATGTIVIEVPNFNDYCP-TLVTREASLCT---
G-AKFINVTVEDRDAHPYGGPFTFTVVDGAERMS-ERWTIGRMDG--TRAQ---LVPQNV
DVGTYEVPLLIKDNQGLSCPEPQILKVH--VCDCVDRTDCRITEP---------------
------------------------------------------------------------
---------------------------------------IVGSSVVLGPAAIALIILALL
----LLL--LVPLLLL--------------------ACGFGSR-L--GLGTGKGFVAIPD
TS-------EEMLRN---W-NSEKAAPDNKA------IPSLISSTAVDSSASHGGLIATG
VGTAAAGIGAAGAGA--------AAGGGGGSSSVFREK------Y--FGREEQTALLSGT
DYR--GMRFG---GG--SGTAA--------------AGSL---------A----------
-A----GGTM--TLGAGR--T---FAMESGSMVN-EDFLRSYFT----------V---KA
EAFADEDETQLAKDCL---LVYSQDEEK--------DSIRGSVGCCSFIE-DDFDDHFLD
D-----LGDKFKTLAEICMGKHV-GMGARQVTT--QVPKA-------ASPILAVNESDVQ
YMHQQNALSS-------------------EQTYT--SGPSFQ-----------------L
PRS--ADH---FGSAARSEETITETKFTS---GLQQTRPI-LDPLVNSSNVVVTETSYGA
-----R----PPMVILDPQFTENVVVTERVLAPASNLQ---TVL------DTPA------
--------------------------------------------GA-FPDLPDSKYVVVR
ERERVLVPSAD-LK--TPLSNL-SEGQNVVVTESVMTP-GTL-RRST-------------
-----------------AD---PYADTERQEH-----VFISDPFQTN----AQELLS---
----------------------------------------------SG-STLSKSSTVTK
YSSVQYSRS----------------

------------------------------------------------------------
------------------------------MDWHIVR--IA------AALLLFLVVL--E
VN--SE-FRVQVRDY-NTKNGTVK-WYS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPFGIFVINQKTGEINITSI-VDREVTPYFIXX
XXXXXX--XXXXLERPLELRVRV LDINGNPPVFSMAT FFGQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIMRQEPSDTPMFIINRYTGEVRTMNNFLDRE----AYAQYGLAVRGS
DRDGGADGL-SAECECSIKIL-DVNDNIPYMELPSXX--XX-XXXXXXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XPLDFEAMK
TMQLGLGVRNKAEFHSSI-RSQYKATATALTVTVLNVVEGPVFRPGSKTYVVNGN-----
MGQNSKVGEFVATDLDTGLTSTT-----ARYVMGTNPTDLLAIDSRTGVITLRNTVTKER
YDMLNGQYRGTILS--IDD---AL-QKTCTGTIIIDLDGWEVEVV---------------
-----------------------------------------TSTG--G------------
-----------------------------------------------------VTGTDRE
GVSGTTSGGH---------RGD-------------------------TATSFD-------
--------------------------ICCDQHPVVGPYDGPSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCSSA---PG--VGAGFEPVPE
CS-------DGAIQS---W-AVEGPQPEIRD------INTICVPSVP----TN-------
------------N-------------------ANIIECIDTSGVY--------TNEYGVR
EMQ-DLGGGERTS--RFELTNGVKMSGAP------------------------EICQ-EY
P--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
S-----LGPKFKKLADISLGKEV-EPYPDFDL---SWPPETTEPVCPPQGT--------G
SV------------------------------------------------ASG---HPPI
SPH----------FG--TTTVISESTY-PSGPGIQHPMPI-PDPLGY-GEATVMESYTTS
-G--TLK---PAVHVRDNRHASNVVVTERVVGPISGAD-LHGIL------DMPDLREGS-
NVVVT--------------------------ERVIAPSSSLPTSLTI-PDPRES-NVVVT
--ERVIRPTPGTMGT-LSMHPDLSSAHNVIVTERVVSG-SGITGISGTAGMS--------
--------GGSGIGSGGL-----VSTSISGAG----------GGLSGA--GVSGGGIGLS
SLSG-------------GMGGTATIGHVRSSADHHFSQT-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
-----------------------------------------IKN---NCLLWHLVIA--G
NA--SL-FLFKV-KE-WDKNGVER-LKT------YRRQKREWIKFAAACREEEDNSKRNP
IARIRSDCEETQ--PIIYRISGVGIDQHPFGVFVINQKTGEINITKI-VDRETNPIFTIN
CHAINP-ITEQSVETPLELRVRV LDINDNAPVFTLATF SGSIVESSMENTLVMKITATDA
DEPNNLNSKIAYKILSQTPGGPSKFILNAANGELH-IANILDRE----EAGQYSLVVQAT
DRDGGPDGI-SSECLCQVS VD-DVNDNFPVLSQSS YS--VS-IIENSLSQDLLRI---QV
EDADLAMTDNWFAEFFFISGNENNNFEIVLDQATNEGILR-VV-----------------
---------------------------------------------------KEIDYEQFS
SIPLSIGVRN IAPFHYSV-ASQYQAHGTPIIVQVNNVIEGPSFNPTTITVSASEGL-T SE
NILTYTVGKFEAIDQDTGRIATNV-----RYEMGHDPAAWFNINPTTAEITFSKVIDRES
IYVINGAYRAEVLA-ICKD---AP-YKTATGTIVLTIQDVNDNCP-VVTDEIRKVCM---
D-NPSVAITAKDLDDHPYGPPFRFTIVAQSPG---SSWTIRIINE--TSAA--LF-SNDV
GFFIHEVQVKVYDNSGRSCERPLVVPLQ--ACHCDRNAMCINGGGGDIDSGRITDGGG--
-------------------------------YDSG--DTYV-------------------
---------------------------PGVGVEREGG------GFALSPAAIFLMFLGGL
----IFV--LVPILM--------------SQSNCCR--YCKS-RPVGG--VGAGFEPVPE
CT-------EGAIHS---W-GIEGAQPEDRD------VSNICVTGT-T------------
-------------------------------KGDFGDS---SDIY--------TTKYDGG
M-V--SR-----E--ETT---GL------GTVKGYGPTVGYETTT-------------GY
G--TTGRTKETF-GGTIKEYRES-G-------VN-MAFLDSYFS----------E---KA
FAYADEDEGRPANDCL---LIYDHEG-I--------GTPVGSIGCCSFIG-DDLDDTYLD
T-----LGPKFKTLAEICLGIEI-EPFPDPNA---PWPSL----------------PNPE
IELNLPPPGT-------------------------------------TIVVNTS---PPV
PPP----------TNIGSTTVVTENTY-T-TSSVQPPRPM-PDPMLH-GNVVVTETYTSV
--P-KLK---PPTLNIDSLHGSNV------------------------------------
--------------------------------------------------------VVTE
--KRVIRPAASMQGN-LGIPPELAGAHNVVVTERVVSG-AGMSGGVGNM-----------
----------GMMSMMS-------------------------------------------
---------------GAGMSGVGGLGPM-LGPDNLLSQT-----MGSASPAT-SRRRVTK
YSTIQYSNQ----------------

------------------------------------------------------------
------------------------------MDWILFR---NI-----CLLIILMV-----
---------SRVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNAPVFTQNI YTASIEENSDANALVVKLSATDA
DEVNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKI L-DVNDNFPVLEKTS YS--AS-IKENCLSSELIRL---QA
IDLDEEGTDNWLAKYVILSGNEGNWFNIQTDPQTNEGILE-VV-----------------
---------------------------------------------------KMLDYEDMP
NVLLNIGVKNQAEFHHSV-ASQFRMHSTPIRIQIINVREGPMFHPSSKTFSIREGI-AGH
SLLTHVLGTYTAIDLDTGNPATDV-----RYIIGRDAGSWLKVDSRTGEIQFSREFDKKS
KYIINGMYTAEILA--IDD---GS-RKTATGTICIEVPDVNDYCP-VIYSERNIICT---
N-SPSVLIYV---SDSSYGLPFTFCVLDQPPETA-HMWDIRSING--KLLK--FIIGYQG
S-NLQTV----------TCLHG-KTHGL--VCPRGGDRVMWGEETTH-------------
------------------------------------------------------------
------------------------------------------AN-----------SSLPL
----SWA--VSPLLLL--------------------LC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMHP---W-RIEGAHPEDRD------VSHICGPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTAVG--AAEGLATAG----A-------------------A
A--GGSRKRSS-TMGTLREYADT-G-------LN-VAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGAT-LSEAEFQAEMAT-AEPVIH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVLAS-PGTPDMSSVAMADA-------
--------CMGPMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MARSPGDRCALLL----LVQLLAVVCL--D
FG---NGLHLEVFSP-RNEGKPFPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSI-LDREETPYFLLT
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDA
DDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDRE----EHSSYSLTVEAR
DGNGQITDKPVQQAQVQIR IL-DVNDNIPVVENKM YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYEEMK
KLDLSIIVTNKAAFHKSI-LSKYKATPIPITV KVKNVVEGIHFKSSVVSFRASE--AMDR
S SLSRSIGNFQVFDEDTGQAA-KV-----TYVKVQDTDNWVSVDSVTSEIKLVKIPDFES
RYVQNGTYTAKVVA--ISK--EHP-QKTITGTIVITVEDVNDNCP-VLVDSVRSVCE---
D-EPYVNVTAEDLDGAQNSAPFSFSIIDQPPGTA-QKWKITHQES--TSVL---LQQSER
KRGRSEIPFLISDSQGFSCPERQVLQLT--VCECLKGGGCVAA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGGGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVA-----DHAESSAVRGG
VG-----GAMLKEGM--------MKG--SSSASVTKGQHELSEVD--GRWEEHRSLLTAG
ATH--HVRTAGTIAANEAV--RTRA----T-----GSSRD---------MS---------
-G----ARG--------------------AVAVN-EEFLRSYFT----------E---KA
ASYNGEDDLHMAKDCL---LVYSQED-T--------ASLRGSVGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGRKI-DLDVDIEQR--QKPVRE----------ASV-SAASG
SHYEQAVTSS-------------------ESAYS--SNTGFP-----------------A
PKP--LHE---VHTEKVTQEIVTESSV-SSRQSQKVVPP--PDPVASGNI-IVTETSYAK
-GSAVP----PSTVLLAPRQPQSLIVTERVYAPTSTLV-------------DQH-YANEE
KVLVT--------------------------ERVIQPNGGIPKPLEVTQHLKDAQYVMVR
ERESILAPSSGVQPT-LAMPSVAAGGQNVTVTERIL------------------------
-------TPASTLQSSYQI---PSETSITARN-----T-----VLSSV--GSIGPLPNL-
--------------------DLEESDRPNS-------------------TITTSSTRVTK
HSTMQHSYS----------------

------------------------------------------------------------
--------------------------------WLLYRVCAALYI---YIL---GKYI--Q
S----R-NKIQVNEG-KSENGTIL-WNT----VQTRRQKREWLAPVVHLREEEDNRHRNP
IAKVHSDKAIKK--QIMYTVSGPGVDMEPYNIFLIDSKTGYLNVTGLKVDREVTPVFFLT
VRAM---SGGADVEKPLSLRIRV IDINDNVPVFSQSV FIGAIAELSSANSLVMQIVATDA
DEVNTLHSKIAYKIISQSPSEPLMFIMNQHTGEVFTVSSNLDRE----ERSSYSLVVSGA
DMDGAAGAL-SGQCGASINI L-DVNDNFPMLEYES YS--VS-VEENAYTXGLLFI---QV
FDHDEMFSDNWLAEFEIVSGNEGGWFVIETDAANNRGILH-VV-----------------
---------------------------------------------------RELNYEALQ
IMNLGIVVRNRAPFHPSI-LSEYQPKVTNIAVQVQNVHEGYAVIPRPLVVSIPAGL-TKE
QMLNYILVKLQMENVDTGEIVSNA-----VYTTDENGSKWLFIDDQG-NVRLIGDLPRDT
TGTGTGTGTGTGSDKCISD---EP---TRTVTTTLTVNVTTPTCP-VISTQQRTICS---
N-NPQVLLQADDGAG-LSTAPFTFSIVSVSDV---SAFTLTNVNGKNV------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------KAKSVALGPAAIGLLIMGFL
----ALL--LAPLLML--------------------LCSCGP-AAK------GTFVPVAD
GY-------DGAYRP---W-GTEGAKPEDVD------VTNLLNMESCC------------
-------------------------------INCINN----ANMS--------TNNYITG
GGL--ESTT---A--PTT-----------AEAGGFGTTRVHSRSF-------------GT
G--LESNAAGSLTGAMSSQYRDG-G------TIN-TAFVENYFT----------E---KA
EAYANEDESRPANDCL---LIYDNEG-M--------GSPPGSIGCCSFID-EDLDDSYLD
N-----LGPKFKTLAEICSGKTP-EPMLRVKE---PIVVT--------------SIPTVE
PNISFSLNDA----------------------------------------VSTV---RQM
PP-----------APVTSSTYVSE-SL-VSSSNLQPAKPI-PEP----GNVLVTETYTTS
--G-------PSVFNFDSLVQPNILVTERVVGPTPG---MRG--------AFPEISDGSN
NVVVT--------------------------ERVIHPASNVPANVNIHSDLMDGQNVLVT
--ERLIQPVANVSSS-RSIHPELVGAQNVIVTEKTVRSAPGIQSHMLSP-----------
----------EPLRSVG----------------------------------STSPSVTRS
R---------VTKY-STVQSGPAVQSHV-LSAEPLLTQA-----VGSTSPSV-TRSRVTK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------------RGLQPV-----AQGSIFIVVL--E
VN--SE-LHVKNKKK-VNEEKDLAPWPS------IRRHKREWVKFARPIRERDDNSKRNP
IATIHSDFQEKQ--HIKYRISGVGIDRPPYGVFIIDENTGAINITAI-VDREEIDTYLIN
CRAVND--WGQDVENLLVLRVKV LDINDNPPIFSQSV FSGQVEENSPTNTLIMAVNATDA
DEPNTLNSKIAFKIISQEPAGAPMFILNRHTGEVRTMTNTLDRE----QFSSYRLLVRGS
DLDGAEHAL-SSDSEIKIE IK-DVNDNFPFFQHSE YF--AQ-IEENSLSSELIRL---KV
TDWDETFSDNWLAEFFFTSGNEGKWFEIHTDKITNEGILS-VV-----------------
---------------------------------------------------KTLDYEQMQ
NVQLGIAVKNVAEFHYSV-IHQYKIQSTPVKIKIINVKEGIVFKPPVKKFTVQRGI-SGQ
AFINYILGTYVAIDEDTGRAATSISK--TRYIMGRNEGGLLAVDSRTAEIRFVKVVERDS
IFIINKTFTAEILA--IDE---KS-GKTATGTVLVEIPDFSESCP-IIGIDRKTVCS---
K-LPSIIVTARAPGSNQNQGPFTFSVSNQPPRQL--LWTIQALNA--TAAE--VRAQQPL
SLGTHSVSLFVKGGQDQNCEASETLTLL--VCDCDSNQRCIDQGTTVPTTSL--------
-----------------------------------------P------------------
----------------------------GGK----TSDRKGWKRARLGPAGIGLIILGLL
----LLL--LVPLLLL--------------------FCDCGA-GTFPG--VGAGFIPVPE
DP-------DGGLHK---W-GIEGAQPKDKE------MGQVCGSTTIV------------
-------------------------------ANGTECVENSGEVC--------TNAYAGG
A-V--VEGA---S--GMEMTTCSRHVTASGFE-----------------------VTNGL
AGFCGTRSRHS-TGGTLRECAEE-S-------VN-MAFLDSYFS----------Q---KA
LACSDEDDVHRVNDCL---LIYDDE--G----IEAPKSPTGSVGCCSFIA-DDLDDSFLD
D-----LGPKFKKLAAISLGLDD-ENQATQSS---MLTPGSQCQALSP------------
---H--------------------------------------------LPCAG-------
-------------------SPSP-TPC-VSVCDPLPMAPV-SDPLHQ-GNFLVTETYTS-
SGS-FCQ---VP---AGTIDSRNMVVTERVFCPVPSSR---GNLGTSP------ELSRSR
NVIYS--------------------------EE-----------PC--------------
--SVLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
--------------------------------------------------KLIIVVA--E
VN--SE-FRIQVRDY-NAKNGTIK-WHS------PRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPYFIIV
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDAPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEPSQQR--VF-IEENTLNSNLLQL---RV
IDLDEEFTANWIGEIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSFGVRNRAEFHQSI-ISQYKITATVVSVTVRNVIEGSVFRPGSKTYVVTSN-----
MQANQKVGEFIATDLDTGLASTT-----VRYVMGDNPTDLLAVDSRTGVLTLRNRVTMEQ
YQMLKGRYQGTILS--IDD---SL-HRTCTGTIIIDIEGFGGPGT---------------
-----------------------------------------QSST--D------------
------------------------------------------------------------
----------------------------------------------------S-------
--------S------TN--T---------NTGTHSDGRTTGGDNVHFGPAGIGLLIMGFL
----VLG--LFEPC------------------------FCHPL---NN--S---ICIPQN
CY-------DGNKSTTHEA-VEAGPRGR--IQWILHAVS------RI----GL-------
------------D------------------N-----AEVEMSVY--------TNDYCAG
EMQ-DLGGGERTT--GFELMEGVKTSAAP------------------------EMCQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
FAYADEEEGRPSNDCL---LVYDIEG-A--------GSPAGSVGCCSFIG-EDLDDGFLD
T-----LGPKFKKLADISLGKEP-ESYPDPDP---SWPPQTTEPTYPPQ-----------
-----------------------------------------------------------V
SQQ----------VG--TTMIVSESTY-PSGPSVHHPLPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNLHAPNVVVTERVVGPISGAD-LHGML------DMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-PTPIESSNVVVT
--ERVIQPTSGMMGS-LNMHPDLSNAHNVIVTERVVSG-AGISGISGAAGISG-------
-----------GMGS----------------------------GLGGA--GISGGG----
-------IGS-------NMGGTATISHTRNSSDHHFTQT-----LGSASPGT-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------LKWMFFP---TV-----GCLGLMWQM-VQA
VK--SE-FFVEVREE-DNENGTAK-WHT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGVGIDRPPFGVFTVDSRTGEINITSV-VDREITPMFLIY
CRAL--NSRGEDLESPLELRVK VMDKNDNPPVFTQNV YTAGIEENSPANTLVVKLSATDA
DEENNLNSKIAFKIISQEPAGAPMFILNRYTGEIRTMTNFLDRE----QHSSYNLLVRGS
DRDGAPDGM-STQCDCRIK VI-DINDNFPTLEETS YS--AS-IEENCLNSELLRF---RA
IDLDEEYTDNWLADFFFVSGNEGNWFEIDTDPRTNEGILR-VV-----------------
---------------------------------------------------KMLDYEQMP
NMYVSIGVKNKAEFHPSV-ASQYRIQSTPVRIRVINVREGAIFNPNSMSFSIRDGI-RGD
ALLNYVLGTYTATDLDTGIAAKNV-----RYVMGHDAGSWLKVDSRTGEIRFSKEFDRKS
KYIHNGIYTAELLA--IED---GS-GRTATGTICVEVPDISDYCP-VIFSDSRSVCG---
A-SPSAIISIRDVNDYSFGSPFTYCVADQPQGTA-TLWEIRSINA--TAAI--LSTGQLL
SSGSYQIPILVKDSLDRTCEMPQILQLD--VCECDVNQMCLFYSTTGIYAGGT----GIT
------------------------------------------------------------
---------------MITDDGYGT----------ITDDRVGESNSGLGPAGIGLIALGLL
----LLL--LSPLLLL--------------------IC-CCKRRTPAD--MGTRFAPVPE
GG-------EGVIQS---W-GIEGAQPEDQD------VSNICVPMTA-------------
--------S------------------------NTQERMDSSEIY--------TNTYAGG
GIV--EGGI---S--GIELNTGAG--EAMGLGAAG------------------------Y
S--GTTRRRSS-TMGTFREFAET-G-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCI---LIYDHEG-V--------GSPVGSIGCCSWIA-DDLDDDYLE
T-----LGPKFRTLAEITLDTEI-EPFPSPHQ---AWMPIST------------DLPLLG
SHY---------------------------------------------------------
-----------------VNVSESSAMS-LTEAGLRAEMAM-PESMFH-GDIIVTESYTTS
--DQCLQ---PTTIVFDPHLASNVVVTETMLAPAYGVQ---GN-----------------
------------------------------------------------------------
----------------LCVPVEANNTHNVIYTERVDHV-AGMSS---SSMTGG-------
------------GTGDC---------------------------------EVIGPEIHVN
Q---------MVDPDLHVVVPDIHISHM-VSPDIHVSQT-----IGPGSPLA-THRRITQ
YSTIQYAQ-----------------

------------------------------------------------------------
---------------------------------------------IVLNNFIFQICF--H
FG---NALHFETLHT-RNANEPPPK-HA-----HSVRQKRAWITAPVSLREGEDLSRKNP
IAKIHSDIAEERRIKITYKYTGKGITEPPYGVFVFDKDTGELNVTSI-LDREETPYFLLT
GYALDE--RGNNLEKPLELRIKV LDINDNEPVFTQDV FVGSVEELSAAHTLVMKINATDA
DEPNSMNSKISYKIVSQEPANPPMFYLNKDTGEIYTVSNTLDRE----ERSSYTLTVEAR
DGKGEVTDKPVKQAQVQIRI L-DVNDNIPMVESQR YE--GT-VEENRVHVEVTRI---KV
LDADERGSDNWLANFTFASGNERGYFRIETDNQTNEGIVI-LI-----------------
---------------------------------------------------KELDYEEIK
HLDFSVIVTNKAPFHKSV-KSQYKPTPIPIKVKV KNVKEGIHFRSSTISI RTSE--SMEK
TSLSQVIGKFEAFDEDTGKVA-RV-----KYTKLEDIDSWVSVDSVTSEIKLVKFPDFES
RYVQNGTYTVKILA--ISE--DSP-RKTITGTVVITVEDINDNCP-TLVDPVLNVCD---
D-VQYVNVTARDLDGYPNSDPFTFVIIDKPAGMA-EEWKIVHKES--TSVL---LQQRER
KPGRSDIQLLISDSQGFSCSEKQILKLT--VCKCLDGSSCVEV-----------------
------------------------------------------------------------
---------------------------------------LHGGYVGLGPAAIALIILALL
----LLL--LVPLLLL--------------------MWHCGEGAK--GF------APIPG
-T-------VEMLHA---W-NNEGAPPEDKV------VPSLLTA-----DQRESVAVGSG
VG-----GVAAKETT-VKG---------GSSASFTRVQHDMSEVD--GRWEEHRSHLSGG
TTQ--VTGTAGAL-QGGETIRTTRA----T-----GIYRD---------MA---------
-G----ARA------------------AAAAAMS-EEFLGSYFT----------E---KA
ACYTEEDDCLVGKDCL---LLYSQED-T--------ESLHGSIGCCSFIE-GELDDHFLD
D-----LGLKFRTLAEVCLGRKI-EMGLEVEQR--PAPVRE----------S-----ASH
SLSEQTRVHS-------------------ESSFS--SAGSVQ-----------------V
PTS--VLE---ASAEEITRETVTERVV-SSKQGQQVAAQL-PDPLAAGNV-IVTETSFAT
-GLTGP----PPAVVLGPRQPQGLIVTERVYAPASAAG---DQRCAHQHYAHQH-YANEG
NITVT--------------------------ERLIQPSGGLSGALEGTAHLPDGHYVMVR
ERESFLAPSSGVQSA-RAQASA-AGGRSVTVTERVL------------------------
-------TPASTLQSSAPV---APQTAMTART-----------VVTGA--VIPGPPPSF-
--------------------SSEESGHSGC-------------------TVTTASTRVSK
HSTVQHSYA----------------

------------------------------------------------------------
------------------------------MHAQFCSYEEM------PFKQTNKVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YR--VD-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTGREES----------T-------------SSTNYETSTIYSE
T-------------------------ASSTLDQNGRQPLLFADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
---------------------------------TIQL---K------INYCDYLVMA--E
VN--SE-FRIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPYFIIV
CRALNS--QGQDLERPLELRVRV LDINDNPPVFSMATFI GQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECDCNIKI L-DVNDNIPYLEKSS YS--IE-IEENALHSDLDQI---RV
IDLDEEYTDNWVAVIFFISGNEGNWFEIEMNEKTNVGILK-VV-----------------
---------------------------------------------------KPLDYETMN
NLQLSIGVRNKAEFHHSI-MAQYKLTATVISVSVKNVVEGSVFRPGSKTYVVTSN-----
MGANSKVGDFIATDLDTGLASTT-----VRYVMGNNPADLLAVDSKTGILTLRNRVTMEQ
YQMLNKRYQGTILS--IDD---SL-HRTCTGTIIIDLEGSGWVTE---------------
-----------------------------------------DSSS--T------------
-----------------------------------------------------QGGSSNT
------------GTTSENTTEDSSGGGTSTN-----------TGG--QSSSDD-------
--------T------DVNNE----------ENGDKNGGAYNGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPH------DLATICVPQIP----PG-------
------------G-------------------ATMMECIDNSGVY--------TNDYCAR
EMQ-DLGGGERMT--GFELIEGVKTPAAP------------------------EICQ-EY
S--GTLRR------NSMRECRE--G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSKDCL---LIYDNEG-V--------DSPAGSVGCCSFIG-EDLDESFLE
T-----LGPKFKKLADITLGKET-VCYPDPDP---SWPPQNTEPIYPQQTT--------G
LV------------------------------------------------ASG---HQQV
SQH----------VG--ATTVISENTY-PSGPAVHHPMPI-PDPLGY-GNVTVTESYTTS
-G--ALK---PSVHLHDNLHAPNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PTPIEPSNVVVT
--ERVIQPTSGMMGN-LSMHPDLSNAHNVIVTERVVSG-AGISGISGAAGLSG-------
-----------GVGSSGL-----VSTNMGVSG----------SGLS--------------
-----GGLSG-------TMGGTATISHMRNSSDHHFTQP-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------------------YEYDLAKHICNVILF--G
VG---HSLHLEVIERSRKGDDKKAV-ST-----KVIRYKREWIIPPVTITEEQDNSWRNP
IAKIQSDYQIDR--RITYRIEGMGVTKPPLGIFIINERTGELNVTGI-VDREETPMFYLK
GYALDQ--NGNNAEPPIDLRVKV VDINDNDPVFTNEV FFGVIEELSPAHTLVLQLNATDA
DDPNTINAKLAYKVISQEPGDIQIFEINKDTGEVYSKVSNIDRE----KQSSYYVVVEVR
DNDGKAGSL-SGTAALKIKVK-DVNDNIPYLEKDQKY--ASHVKAYCLPS-TYVF---II
IKQDPLLSAYWGAVYILVQIEFSEYFFVLTTKCVGQGLLYLLH-----------------
---------------------------------------------------REVDYEMMQ
NVELSVVVSNKAVYHSSI-KSQGGAKTVSIKVKVKNVPEGPVFKPNRKTLLISE----GK
TKVQTVIGSYRAYDGDTGKVAENV-----KYAKEYDPDNWFTIDPITADIKLIKLPDRES
IYVVNGIYVAKILA--ISE--DLP-GKTATGTIAIEVGDENDNCP-TIINPIQTVCN---
T-ADFINVTAVDRDDFPFGAPFNFSIIDEPPGYA-KFWTIGPSNG--SSWFSVQLKPQNI
WDGPQKVHILVKDNQGLSCPEKQILSLF--ICTCVNGDACNER-----------------
------------------------------------------------------------
---------------------------------------MVDKSVKLGAAAIGLMILTCL
----LLL--LVPLLLL--------------------LCYCGSAGK--GF------MAIPD
GT-------DATFVK---W-NNEGAAPENMS------MDGMY------------------
--------------------------------------HSSSIMD--RRWEEQRRLISEA
EFA--QAGAAGTT------LRSMAM----L-----GSGSG---------SG---------
-G----AV-----MGGAYSSA---IIAGGGAALD-EGFIREYFS----------D---KA
FGYSDEDQAQPAKDCI---LTYTQED-A--------GSLSGSVGCCSFIE-SEFDYDCLD
D-----LGMKFKALADICQGMQT-NTVISPSLQ---------------------------
-----NMI----------------------------------------------------
--D--LKD---G------------------------------------------------
-----------------------------------------------------------Q
NVMVT--------------------------KRVITSDKARPGLVA-ASDSVDSQYVVVT
--ERVLAPSSGLQTS-LSIPDL-AVGKNVVVTERHYTP-IQGNV----------------
-----------------IL---PTEIS---------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-------------------------------------RTCNS-----TLFKFLQMFV--L
VH--GE-LWIE---P-HGEDDTAVQ-QG------KRRYKREWVKFATPCREREDNSKKNP
IAKITSDFQTTQ--KITYKISGVGIDQPPFGIFIVDPNTGDINITAI-VDREETPSFLIT
CRALNV--LGQDVEKPLILTVKI LDVNDNAPVFSQTIF KGEIEENSNSNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTPMFLISRNTGEVRTLTNALDRE----QVSSYRLVVSGT
DQDGVG--L-STQCECEIK VK-DVNDNFPVLKYAQ YS--AR-IEENTINSDLLRF---QV
TDWDEEYTDNWLAVYYIISGNQGKWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KPLDYEQIQ
SMQFSITVKNKAEFHQS V-ASQFQVQSIPVIIEIINVREGISFRPISKTFTVQKGI-STK
KLI NYVLGTYEAIDEDTGKTSSAV-----RYVMGRNDGGLLTIDPKTGQIKFVKNIARDS
TFIVNKTLTAEVLA--IDE---ST-GKTATGTVYVKIPEFNENCP-PIVLEKNEICS---
S-SPSVVVSARTLERDRYAGPYTFSVEEQPLKLP-VIWRITSLNA--TSAM--VRAQQQI
SPGVYRVPIVVTGDQDRRCESSETLTLT--VCQCDERGSCRASWEEPQI-----------
------------------------------------------------------------
-----------------------------E---------PRKQIYRMGPSAIGLLLLGLL
----LLL--CEYASLS--------------------PRVCS-MTF---------------
--------------------TLK---------------SSYCT-----------------
-------------------------------HEGEEFSPLFLEVC--------TNTYTGG
T-V--VEGV---S--GMELATKVGAT---------------------AAGAGLGPCPPGH
LGLGTTRTRHS-TGGTLKDYTDG-T-------IN-MNFLDSYFS----------Q---KA
FACAEEEGVQEANDCL---LIYDNEG-T----DDGRSSPVGSLGCCSFIA-DDLDDSFLD
S-----LGPKFRKLAEISLGIDE-EAKQAQPH---AQSSGTGVDLCGP----SVE-----
------------------------------------------------------------
-----VQQSGPDRYQTFWGSQEAHSLP-TYGS-LQQAIPI-PDPLQH-GNYLVTENYSA-
SSS-FVQ---PTTAIF--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVVT--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NARGEDLESPLELRVK VMDVNDNPPVFTQNV YTANIEENSEANALVVKLSATDA
DEDNHLNSKIAYKIIAQEPTGAPMFMVNRYTGEVRTLSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SAECDCRIKV L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEEVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQ IVNVREGPTFRPNSMTFSVREGV-RGD
AS LNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGMYAAEILA--IDD---GS-GKTATGTICIEVPDASDYCP-VIYSG-RTICV---
D-SPSIFIYV---SDHSFGAPFTFCVVDQPSEVA-NMWDIQTING--TSAI--LTAQQPL
SPGTYQIPILVKDSYNRACELPQIVQLI--ACVCDN-NVCLHSSTTGIYTGDV------S
------------------------------------------------------------
---------------GA-TDIYGS----------TTDDGVGESNVRLGPSGIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------ALNVCPPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTAVG--AAAGLVAGG----A-------------------A
S--GTLRKRSS-TIGTLREYQDTAG-------LN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEIAT-CEPVIH-GDIIVTETYTTT
--EPCVQ---PTTIVFDPQLPTNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVMSS-PGLPDMSNTSMADG-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
Q---------V------------------C-PDIHISQT-----IGSTSPIT-SRHRVTR
YSNIHYSPQ----------------

------------------------------------------------------------
------------------------------MTWFPF---RTT-----GALTILMVIL--L
VH--GE-LRIETKRQ-HGEDETAVQ-QA------KRRYKREWVKFARPCREGEDNSKRNP
IATITSDFQATQ--KITYQISGMGIDQPPFGIFVVDRNTGEINITAI-VDREETPSFQIT
CHALNV--LGQDVEKPLILTVKI LDINDNAPVFSQSVFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGIPMFLLSRHTGEVRTLTSSLDRE----QVSTYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPIFRESQ YS--AR-IEENTLSSELIRF---QV
VDRDEEFTDNWLAVYFFTSGNEGQWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KPLDYEQLQ
NVQFSIAVKNKAEFHQSI-ISQYRVQSTPVIIQ VVNVKEGISFRPPSKTFTVQKGI-SSK
T LVNYILGTYQAIDEDTNKAASNV-----RYVMGRNDGGLLIVDSTTAQIKFVRNIDRDS
TFIVNKTITAEVLA--IDG---DT-GKTSTGTIYVKVPDFNENCP-TIVLEKKTICS---
S-SPSVIVSARALDNDKYTGPYTFSLEEQPVKLP-VVWSITTLNA--TSAV--LRAHQQL
SLGTHRVSLIVT-GQDRLCETPESLTLE--VCQCTNRGICGTDG-TTDP-----------
------------------------------------------------------------
-----------------------------GN------VRDTKSSMRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGT-GPIGG--MTGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-LIT------------
-------------------------------ANGADF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTKLGAATGSGAAAGF----------------GLGVCSTGQ
S--GMMRTRHS-TGGTNKDYSEG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----VGAPGSPVGSLSCCSFIA-DELDDSFLD
S-----LGPKFKKLAEISLGVDD-EAKQSYTP---TKDGGSGIESSGY----SVEVQQS-
------------------------------------------------------------
---------ESARYQTLSGSQGASALS-ASGSVLQPAISI-PEPLQH-SSFVVTETYSA-
SGS-LAQ---PSTAVFDPLLTQNVTVTERVICPVSNVP---GNLHGPM------EIRGSR
TMICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHSFR--TA------AALLTFLVIN--R
HY--VLLSLFKVRDY-NAKNGTIK-WHS------NRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELKVRI LDINDNAPVFSMTTFI GQIEENSNANTLVMVLNATDA
DEPNNLNSIIAFKIVSQEPSDSPMFIINRKNGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEQSS YD--IS-IQENELHSQLMEI---RV
IDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMK
NLQLSIGVRNVAEFHQSI-ISQYRLTATMITVTVLNVIEGSVFRPGSKTFVVNSK-----
MGANYKVGDFVATDLDTGLQS-----TNVRYVMGNNPADLLAVDSRTGIITLRNRVTMEQ
YQMLNRRYEGTILS--IDD---SL-QRTCTGTVIIELSGSGWVTS---------------
-----------------------------------------TDQN--T------------
-----------------------------------------------------EDGGSTS
GSGDNTGGGTSG-NT---STEQTTGS-----------W--DDGGGN-GGTGGNGGTDGDT
----------------------------YDNGDGGERQRRPGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQML----PG-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKDI-DSYQGPEP---SWPPQSTEPVCPQQ-T--------E
PL------------------------------------------------PSG---HPPI
SPH----------FG--TTTVISENTY-PSGPGVQHPMQI-PDPLGY-GNVTMMESYATS
-G--TLK---PSVHFHDNRQASNVVVTERVVGPISGAD-FHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNPRESSNVVVT
--ERVIQPTSTMMGN-LSMSPELSNAHNVIVTERVVSG-GGVSGISGTAGLGG-------
--------GIGGIGSGGL-----VSTTMGAGG----------GGLSGG---------L--
---------S-------GMGGTATIGHMRSSSDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--VV------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYALAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--IE-IQENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRN KAEFHHSI-MSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGS NDKVGDFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTREQ
YNMLGGKYQGTILS--IDD---NL-QRTCTGTININIQSSDKDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TESNTEI
T--------------TNTGRQES----------T-------------SSTNYDTSTISTV
SS------------------Q-----VFTPAPGNGVRE--LSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----IT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHIHDNRPASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------SALSGA--GISGGGIGLS
S-----------------LGETASIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWLPFR---NI-----CLLIILMXXXXXX
XX--XX-XXXXXXXX-XXXXXXXX-XXX------XXXXXXXXXXXXXXXXXXXXXXXXX-
-XXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXIY
CRAL--NSRGEDLERPLELRVKVMDINDNPPVFTQNVYTANIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIVSQEPSGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAMDGL-SSECDCRIKV L-DVNDNFPTLEKTT YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLANYVILSGNDGNWFDIQTDPRTNEGILK-VVKXXXXXXXXXXXXXXXX
XXXXXXX--------------------------------------------XXXXXXX--
-XXX---XXXXXXXXXXX---XXXXXX---X-XX--XXX--XXX----------XX-XXX
XXXXXXXXXXXXXXXXXXXXXXXX-X--XXYIIGQDAGNWLKVDSRTGEIQFSREFDKTS
KYITNGIYTAEILA--IDD---GS-GKTATGTICIEVPDTNDYCP-IIFAESQSICI---
N-SPSTIISV---NQHSYGSPFTFCVVDQPPGTA-DLWNIKSINA--TSAV--LTAVQPL
LPEFYQIPILVKDSYNRECESPQTVQLL--GCDCDYNQMCLYPSTTDIYSSV--------
------------------------------------------------------------
-----------------TNDIY------------ITDDHVGGSNVGLGRTGIGMIALGAL
----LLL--LSPLLLL--------------------IC-CCKRRKPEG--LGTRFAPVPE
GG-------EGVMQS---W-GIEGAHPEDRC------GGPADSD----------------
-------CYTSHT------------------PAYLQELSLLSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLAAGG------------------------A
S--GAIRRRSS-TLGTQWEFADT-G-------LN-MAFLDSYFS----------D---KA
YAYADEDKGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNDSSGMN-LSEAEFQAEMAI-PEPRLH-GDIIVTETYTTS
--DQRMQ---PTTIVFDSQLAPNVVVTETVMTPVYDAQ---GN-----------------
------------------------------------------------------------
----------------ICIPAELADTHNVIYTERVLSS-S---DMNNSITADG-------
--------CMGPLMSGS---------------------------------ILVGPEIQVT
Q---------MV-----------------N-PDIHISQT-----IGSTSPMT-SRHRVAH
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
IG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVANKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISIYVSE--RM DR
SSKGQIIGNFQAFDEDTGLPA-HA-----RYVKLEDRDNWISVDSVTSEIKLAELPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLINVEDINDNCP-TLIEPVQTICH---
D-AQYVNVTAEDLDGHPYSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGDSLVGRNG
VG-----GMA-KEAT-MKG---------SSSASIVKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--FTGATGAI-MTTETTKTARA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SLYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNV-IATETSYVT
-GSTMP----PTTVILGPSQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMKARN-----T-----TVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YR--VD-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVT VLNVIEGAVFRPGSKTYVVTGN-----
MGS NYKVGDFVATDLDTGGPSTT---VRYRYVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQANTTD
---------------TNTGREES----------T-------------SSTNYETSTIYTL
SQ------------------Q-----VDSTPYQNGEQVPLFADNVHFGPAGIGLLIMGFL
----VLGSPVVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPQPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------LYRS---E-----AFF-LVALLLLICL--N
YG---HGLYVKVYNRND-RSGMLSH-PN-----SLVRQKREWTVPPAFIREEEDNSYKNP
IARIHSDL-EDTGIVVTYTISGQGVTEPPYGLFVIDGKTGNLNITGR-VDREKTPFLLVR
GHALDK--NGAKLEEPIDLPIKVVDINDNFPVFSHEVFVGSIEELSETGTIVMRINATDA
DEPNNLNSKIAFRIVSQSPS--AAFSMDKNTGEVRVAKINLDRE----TQSSYSLVVEAK
DRGGQAGGN-AATCSLEIK IL-DVNDNLPVVESHAFE--GS-IEENRANVEIMRI---KV
FDKDEEFSDNWLAKFTFVSGNEDGFFQIVTDPQTNEGILT-VV-----------------
---------------------------------------------------KALDYEKMQ
SLNLGIVVTNKAEFHK SI-KPSYKAETIPIKIKVINVREGPVFPGGTK VIEASEK-----
LQIKQVIGQYQAYDEDTGKIAEHI-----TYMKGKDAANWVTVDPVTGEIRLAKNLDYES
PHVVNGTYTITMLG--VTT--DSP-RKTVTGTVVIQVQDENDNCP-VIVNPVQTVCS---
D-AKLVDVTAHDLDSYPNSYPFSFTVIDEPEGTA-ENWIIASGND--TSIQ---LVPQNL
KPGRTEVPMLIKDFQGVSCALPQSLQLT--VCKCADDGVCQEK-F---------------
------------------------------------------------------------
---------------------------------------VGAKSVGLGPAAVALIILAFL
----LLL--LVPLLLL--------------------LCPGGLGAK--GFGGAKTFADIPD
HS-------EAMLRQ---W-NSEGAAPEEKP------VLSFIPPTALGNL----------
--------GMSGQEV--------LI-GAGSSASHVGEHH-STTTR--ERWEEQRRLLSAA
DYG--ATM-A---AGAAEGMA---------------------------------------
-G----VDGK--TVMSGG--G---VAVGAAGAMN-EEFLRDYFN----------D---KA
VSFADEDEEQAAKDCL---LVYSQGE-S--------GSPHGSVGCCSFIE-GDLDDHFLD
D-----LGEKFKTLAEICIGRQI-NMKE---------------GGYKNESGFGLSESKSQ
FLDQQNASTS-------------------EQTFA--SGSAFQ-----------------S
VPP--MHTGSGAGESTLSKEVVTETTFSSSHSGQHSARHL-PAG-QAESNVSMTETSYSV
-GAPAR----SAPVFLDPQFKENVVVTERVLAPASSIQ---GMV------KIPE-LPHGS
NVVVT--------------------------ERVVKSAGAGPGALA-VQDLPDSQYVVVR
ERERVLVPAAE-QGS-LSFPTS-TEERSTVLSERVLAA-SGLQGRAE-------------
-----------------QA---AGASSGRQEH-----ALITDSPLNLMGSDVQGPSP---
----------------------------------------------AG-ATLSKSSRVTK
YSTVQYTRS----------------

------------------------------------------------------------
------------------------------MDWHLLR--AA------AGLFLLLVVV--E
VN--SE-FRVQVRDY-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--KVTYRISGVGIDQPPYGIFIVNERTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPIFSMST FVGQIEENSNANTLVMIINATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTXXXXXXXXXXXXX----TYSQYALAVRGS
DRDGGIDGI-SAEVECSIKI L-DVNDNIPYLEQST YT--IN-IEENALYSELLLM---RV
IDMDEEYSANWIGDIFFISGNEGGWFAIEMNERTNTGILK-VI-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSLGVRNKAEFHQSI-MSQYKLTATAVTVTVVNVIEGAVFRPGTKTYVVTGN-----
MGKNYQVGDFIATDLDTNQPSSTVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---
XXXXXXXXXXXXXX--XXX---XX-XXXXX-XXXXXXX-X-XXXX---------------
-----------------------------------------XXXX--X------------
-----------------------------------------------------XXX-XX-
-------------XXXXXXXXXX----------X----------X--XXXXXXXXX--X-
--------X-----------X------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----XXX--XXXXXXX--------------------XXXXXXX---XX--XXX-XXXXXX
XX-------XXXXXX---X-XXXXXXXXXXX-----XXXXXXXXXXX----XX-------
------------X------------------XXXXXXXXXXXXVY--------TNEYCGR
EMQ-DLGGGERTT--GFEVTSGVKTSGMP------------------------EICQ-DY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPAGSVGCCSFIG-EDLDDNFLD
T-----LGPKFKKLADISLGKEV-EPCPDFDP---SWPPERMEPVCPPQGT--------E
LI------------------------------------------------PSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVHHPMPI-PDPLSY-GNVTVKESYTTS
-G--TLK---PSVHIHDNRQASNVVVTERVVGPISGAD-FHGML------DMPDLRDGS-
NVIVT--------------------------ERVIAPSSGLPTTLTI-PDPREASNVVVT
--ERVIRPTSGVMGT-LGMHPELSNAHNVIVTERVVSG-AGIAGISGTAGIS--------
--------GGGGLGSSGL-----VGPSLTAGG----------GGLSGA--GMSGGGIGLS
-----------------SMGGTATIGHVRSSSDHHFSQT-----LDSTSPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--TA------AVLFIFLVVV--E
VN--TE-FRIQVRDY-NAKNGTVK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--KVTYRISGVGIDQPPYGIFVVNSKTGEINITSV-VDREVTPYFIIY
CQALNS--LGQDLERPLELRVRV LDINDNPPVFSMSEFI GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGL-SAECECNIKI L-DVNDNIPRLD----S--VL-IDENTLNSNMLEF---TV
IDLDEEFSANWIGVPFFISGNEGNWFEIEMNERTNMGILK-LV-----------------
---------------------------------------------------KPLDYEAMK
SLQLSIGVRNKAEFHQSI-MSQYKLTATAISVIVNNVIEGSVFRPGSKTYVINPG-----
MGVNHKVGDFIATDLDTGAASTT---VR--YVMGNNPFDMLSIDSKTGIITLRNKITMEQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDLDGWDRGNN---------------
-----------------------------------------DNTG--T------------
-----------------------------------------------------SSTGTTD
T--------------SSTGNDLN----------G-------------GSTSVSTGE-YGT
GS------------------E-----DV----TTSEFDITPTHNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---PG--VGAGFEPVPD
CS-------DGAIHS---W-AVEGPQPEPTG-----LI---PVTQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELTDGVKMPGMP------------------------EICQ-DY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDT-EPYPDPDP---SWPPQSTEPVCLHQET--------E
AI------------------------------------------------ARG---HPPI
SPH----------FG--TTTVISESAH-PSGPGVQHPMPI-PDPLGY-GNVTMTESYTTS
-G--TLK---PSVHIHDNRQASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-PSPRESSNVVVT
--ERVIQPASGMIGN-LSMHPELANAHNVIVTERVVSG-AGVTGTVGVSGG---------
--------G--GIGS--------------LGA----------GGLSGA--GVSGGGIGLS
S-----------------MAGAATIGHMRSSSDHHFSQT-----LGAASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLI---------
-------------EL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARVSDEASR-------------GSLSFAQDLFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVKVMDVNDFPP----NVYTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYSILSGNDGNWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEEVP
NIYLSIGVRNKAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFRPSSMTFSLREGV-RGD
SLMNYVLGTYTAIDTDTGNPATNV-----RYTIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGIYAAEILA--IDD---GS-RRTATGTICIEVPDANDYCP-IIYSERRSVCV---
D-ASSVRIYV---SDHSFGSPFTFCVVDESSDTA-SIWNIRSINE--TSAI--LMTEQTL
SPGLHQIPILVTDSHNRACELPQTVLLD--ACFCDDHQVCLHSSTTGIYSGDT------I
------------------------------------------------------------
---------------WVTDDTYG------------TDDGVGQSNVRLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTAVG--TTAGLVAGG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMEAASEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVYYAERVVAS-PGVPDMGNSNMTDA-------
--------CMGPMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSNSPMT-SQHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLMLLMVVL--G
VN--SE-FIVEVKEL-DVENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTATIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAEYSILSGNDGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEEVP
NIYLSIGVRNKAEFHHSV-VSQFQMHSTPVRIQV LNVREGPTFRPSSMTFSLREGT-RGD
SLM NYVLGTYTAIDTDTGNTATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDAKS
KYITDGIYAAEILA--IDD---GS-GRTATGTICIEVPDANDYCP-VIHTERRSVCV---
D-ASSVRIYV---SDHSFGSPFTFCVVNEPSDTA-SIWHIRSINE--TSAI--LMTEQTL
SPGTHQVPILVTDSHNRACELPQIVLLD--ACFCDDLHVCLHSSTTGIYNGDG------T
------------------------------------------------------------
---------------WVTDDTYGT----------VTDDGVGQSNVRLGPAGIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGIG--TAAGLVAGA----A--------------------
A--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMEAASEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------LCVPAELANTHNVYYAERVVAS-PGMPDMGNSNMTEA-------
--------CMGQMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSSSPVT-SQHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWSFFR--VV------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYALAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--IE-IQENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRN KAEFHHSI-MSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGS NDKVGDFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTREQ
YNMLGGKYQGTILS--IDD---NL-QRTCTGTININIQSSDKDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TESNTEI
T--------------TNTGRQES----------T-------------SSTNYDTSTISTV
SS------------------Q-----VFTPAPGNGVRE--LSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--STAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----IT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHIHDNRPASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------SALSGA--GISGGGIGLS
S-----------------LGGTASIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------TKVNATDA
DEPNTVNSELSFRILSQQPV--PAFYIDQYTGEIYTISSNLDRE----EHSSYSLIVDVR
NKNVQITDRPAKQAQIQIHI S-DVNDNVPVVENKV YK--GS-VEENQANVEVIRI---KV
SDADEVGSDNWLANFTFVSGNEEGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KDVDYEQIK
HINCTVIVTNKAAFHKSV---KFKPVHIPFTV DIQNVKEGIHFKSSKISF QVSE--SMNQ
SSISRVIGKFQAFDEDTGKLA-HA-----KYSKLEDIDNWITIDSVTSEIRLAKIPDFES
RYVKNGTYTVKIVA--VSE--DDS-RKSVTGTILLNVVDINDNCP-TLVNPVQNICN---
D-EQYVNATAEDLDGPENSGPFNFLIVDKPPGMA-EKWKIVRQEG--TSVL---LQQHEQ
KPGRSEIQFLISDVKGNTCPEKQILQLT--VCECLHGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------LHSSYIGLGPAAIAIIILAIL
----LLL--LVPLLLL--------------------MATCGEDAK--GF------TPIPG
-T-------VEMLHP---W-NNEGAPPEDKV------MPSLLTT-----DRRESVAVGHA
VG-----GSTANRVMVGKG---------SSSTSFVKRQHEETEVD--GRYEEHQSLLTGG
ATR--PAGTIGAAI-SA--ERNRRV----Q-----AASTD---------MA---------
-G----AR-------------------AAAVAAN-EEFLKNYFF----------E---KA
ASYTEENDFHTARDCL---LVYSQDD-T--------QSLHGSIGCCSFID-GELDDICLD
D-----LGLKFKKLAEVCLGRKI-DIDLETEQK--AKHGTE----------GSSVNEQSQ
GLSEXXXXXX-------------------XXXXX--XXXXXX-----------------X
X------------XXXXXXX--XXXXXXXXXXXXXXXXXX-XXXXXXXXXXIVTETSYTT
-DSALP----PSTVILRPSQPQGLVVTERVYAPATTV--------------DQR-YPNDG
NVVVT--------------------------ERVVQPNGGLVGLQEGATHLSDANYVMVR
EKESFLASQASMLHT-LARPSV-AIGPNVTVTERVL------------------------
-------TPASSVQSSYQV---PAESSVTVRK-----T-----SVSRIG---PAPQPNS-
--------------------ASECPHAPTT----------------------AAPSRASE
-QSRIHSYSR---------------

------------------------------------------------------------
-------------------------EKPEGMDWLLFR---NI-----CPLIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEVNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPIFLIY
CQAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YIASIEENSDANTLIVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILDRYTGELRTMSSFLDRE----QHSTYNLLVRGS
DRDGATDGL-SSECDCKIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELMRL---QA
IDLDEEGTDNWLAKYLILSGNEGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NMHLSIGVKNQAEFHHSV-ASQFQMHSTPVRIQ VVDVREGPTFHPNSMTFSVREGL-RGD
SL LNHVLGTYTAIDLDTGNTATNV-----RYIIGHDAGSWLKVDSRTGEIQFSRELDKKS
KYITNGIYTAEILA--IDD---GS-EKTATGTICIEVPDVNDYCP-VIFAESKTICI---
D-SPSVLISARDVSDHSYGSPFTFCVVDQPRGTA-DLWDIRSINA--TSAI--LTAVQPL
FPGPYQIPILVKDNYGRECELPQIVQLD--ACDCDSNHMCLYATTTGTYTADTADTADVS
------------------------------------------------------------
---------------LVTSDVYGS----------VTDNRIRDSNVGLGPAGIGMMVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVIQS---W-GIEGAHPEDRE------VLNICVPT--T-----D------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GTV--EGGA---S--GVELNTGLG--TAAGLVAVG------------------------A
A--GTMR-RSS-TMGTLREYSES-G-------VN-MAFLDSYFS----------E---KA
HAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSTGCCSWIM-DDLDESYLE
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
SNY---------------------------------------------------------
-----------------F-VNESSEMT-LSEAEFQAEMVM-PEPMIH-RDVIVTETYTTA
--DQCVQ---PTTVVFDPHLAPSVVVTETVMAPVYDVQ---GH-----------------
------------------------------------------------------------
----------------VCVPTELANTHNVIYTERVLSS-PAMPGTSSSSMNDG-------
--------CMGPVMSGS---------------------------------ILVGPEIQVS
Q---------VV-----------------N-PDIHISQT-----TGSTSPMT-TQHRVTQ
YSSIHYSQQ----------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------F
CLQIRSDCEANQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFTQNV YMASIEENSEANSLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGASDGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IEENCLTSELIRL---QA
IDLDEEGTDNWLAKYSILSGNDGEWFDIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NVHLSIGVKNQADFHHSV-ASQFRMQSTPVRIQVVNVREGPIFHPSSMTFSVREAK-TGD
SLSNYVLGTYTAIDLDTGNPATNK------FDKWHDAGNWLKIDSRTGEIQFSREFDKKS
KYITNGIYTAEVLA--IDD---GS-GKTATGTICIEIPDVNDYCP-VIFPESRYVCT---
T-SASVIIYV---RDHSYGSPFTFCVVDEPPGTA-DLWDIRSING--TSAI--LTTEQFL
SPGPFQIPILVKDSFNRACIYTEDI----------------------------------S
------------------------------------------------------------
---------------LVTNDMDGS----------DSDDRIGASNVGMGPAGIGMMAVGAL
----LLL--WVVRQLN--------------------MGNACTSKDPQM--TVIPFRLPSQ
YLHMEIKERPGIGKS---N-LNAGSTT--IS------QNALCYGEGVVGCCWRG------
--R----FTTTPM------------------QVEEQLKGEYQESW--------DSCWPGG
WRG--SGHH---K--EKELH----------------------------------------
--------HGN-SAGICRHWREH-G-------------FSGQLL----------H---RA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYIE
T-----LDPKFRTLAEICLDT---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MTCPFP---RVL-----GPLALLMVM----
----RS-LSTQPGGQ-HREDGTAVQQ-V------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDPNSGDINITAI-VDREETPSFLIT
CRALNA--RGQDVERPLILTVKI LDVNDNAPIFSQTIF KGEIEENSASSXXXXILNATDA
DEPNHLNSKIAFKIISQEPAGMPMFLISRNTGEVRTLTSSLDRE----QVSSYHLVVSGA
DNDGRG--L-STQCECSIK VK-DVNDNFPLLTDSQ YS--AR-IEENTLNSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
STQFSIAVRNKAEFHQSV-ISQYRVQSTPVIIQ VINVREGISFRPPSKTFIVPKGV-STN
KL AGYILRKHQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAQIKFVKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVHVEVPSFSENCP-SVVLEKEEICI---
S-LLI----------------------------------CTFFVA--TSAL--LRAQQQM
SPGVYSVPVTVKDNEGRQCDTPEILTLT--VCQCDDRSMCRAPTPSRGP-----------
------------------------------------------------------------
-----------------------------II--------YRESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGA-GPIGGGAETGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V-------------------LGAATGSAA------------------TGALGPCSLAH
S--GTMRTRHS-TGGTLKDYVAA-P-------VN-MTFLGSYFS----------Q---KS
FAYAEEEGEREVNDCL---LIYDDEG-E----DAAPCSP--ALSSCSFIA-DDLDDSFLD
S-----LGPKFKKLGEICLGIDD-EAKQAKPG---PKGSGSGADICAR----PTEVPQSG
SQRYQTLPGSLEVPQSGSQRHQT-------------------------------------
----------------LSGGQDASVVF-TSGS-VHPAIAI-PDPLQL-GNYLLTETHST-
SGS-FVQ---PTTATFEPHLTQNVTVTERVICPLPSVS---GSIVAPT------ELRGSY
NMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------ICF--T
FG---NGLHFEALNT-RNENKSPPQ-RA-----HLVRQKRAWITVPVALREGEDLSKKNP
IAKIHSDLAEERGVKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPYFLLV
GYALDE--RGNNLEKPIELRIRVLDINDNEPVFTQDVFVGSVAELSSAHTLVMKINATDA
DEPNTMNSKISYRIVSQEPAYPSAFYLNKDTGEIYTTSVTLDRE----QHSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVENEM YE--GA-VEENQANVEVMRI---KV
FDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIIVTNKAAFHKSI-KNKYKPTSIPIK VKVKDVKEGVRFKSSTVSVHASE--TM DR
SSRGQVIGKFEPFDEDTGKPV-RV-----KYAILEDIDNWVYVDSVTSEIKLAKIPDFES
RYVKNGTYSVKILA--ISE--DYP-RRTITGTVRISVEDTNDNCP-TLVDPVQTVCN---
D-VQYVNVTAEDLDRFPNSEPFRFSVVDKPPGMA-EKWKIIRQES--TSVL---LQQSQR
KLGKSEIQFLISDNQGFSCPEKQVLTLT--VCECLDGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------LHNSYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TAIPG
-T-------VEMLHP---W-NNEGAPPEDKV------VLPLLGV-----DQVDGLAVRNG
VG-----GII-KEAT-VKG---------SSSASFTKGHHEMYEAG--RKWKEHRSLLSGG
ATQ--VTEAAGAG-LGAETMRTTRV----S-----GASRG---------MT---------
-V----T-----------------GAQAAAVAVN-EEFLRSYFT----------D---KA
ASYTGDDETHMAKDCL---LVYSQEE-T--------DSLRGSIGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGQKI-DTDMEIEQK--QKPVAE----------TGV-NTASR
SLYEQTVADS-------------------GNAYS--PGSSFQ-----------------V
PKS--LHE---ANGEKITQEIVTEKSV-SSKQVQKVATPL-PDPLVSNDI-IVTETSYAT
-GSTVP----PSTVILDPRQPRSLIVTERVYAPASGLV-------------D---YANEG
KVVVT--------------------------ERVIQPNGGIPNPLEGTQHLQDAQYVMVR
ERERVLAPSSGVQPT-LAVPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PVEDSVKVQE-----T-----LVSGA--VAPGPLPNF-
--------------------GLEESGHSNS-------------------TMTTSSTRVTR
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLYLQVSST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-TVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
---------------------------------------------------ILQICC--N
FG---NGLHLEVFNT-RNENELLSK-HT-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEEKGLKITYKYTGKGITEPPFGVFVFNKNTGDLNITRI-LDREETPYFLLM
GYALDV--RGNNLEKPLELRIKVLDINDNEPVFTQAVFAGSIEELSAAHTLVMTVIATDA
DEPNTMNSKISYRIVSQEPASSPVFYLNKDTGEIYTTSVALDRE----EHSSYTLTVEAR
DGNGQITDKPVTQAQVQIR IL-DVNDNIPVAEKET YE--GT-VEENKANVEVIRI---KV
FDADEIGSDNWLANFTFASGNEKGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEIK
NLNFSIIVTNKAAFHKSV-KNKYKPISIPIT VKVKNVKEGIHFKSSTISIRTSE--SMDK
ASLSRIIGKFEAFDEDTGKLA-QV-----RYAKLEDIDNWISVNSVTSEIRLVKIPDFES
RYVHNGTYTAKIVA--ISE--DYP-RKTITGTIVITVEDINDNCP-TLINPVQTVCD---
D-VQHVNVTAQDLDGYPYSWPFSFSIIDTPAGMA-ERWKIVHQES--TSVL---LQQSER
KLGRSEIPFLISDRQGFSCPEKQTLDLT--VCNCLDGGGCVEA-----------------
------------------------------------------------------------
---------------------------------------LRDSYVGLGPAAIALIIFALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VSSFVAA-----DHG--VHVSSG
VG-----GVTSKTIT-K-G---------SSSSCYTKGH----EV--DGRWRERRRLISVD
PPQ--VTELTRV--IDSETITTTRT----T-----GASRD---------MT---------
-G----AE-------------------AAAVALS-DEFLRNYFT----------E---KA
ASYTEEDDVHLGKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GELDDGFLD
D-----LGIKFKTLAEVCVGRKI-NIDMQIEQK--PKPVRE----------TGV-KTASH
SLYEQTKVNS-------------------ENASS--SGSSFQ-----------------V
PEH--LHE---ANAEKVTQEVVTERSV-SSWQGQKVPRPL-PDPLPPGNV-ILKETSYAT
-GSTMP----PSTMILGPSQPQGLIVTERVYAPASTLV-------------DQH-YASEG
NVTVT--------------------------ERIIQPNGGVSGPLEGTQQLPDAHYVMVR
ERESFLAPSPAVQPT-LTMPSV-AVGQNVTVTERVL------------------------
-------TPASALQSGFQI---PAETSVTARK-----T-----VVSGA--GVTGPAPNF-
--------------------SLEESGHSHS-------------------TVTASSTRVSK
HSTVQHS------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLVVLMVVL--E
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEASQ--KITYRISGPGIDRPPYGVFTINSRTGEINITSV-VDRETTPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNPPVFTQSV YTAAIEENSEANALVVKLSATDA
DEDNHLNSKIAYKILSQEPAGVPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IKENCLSSELLRL---QA
IDLDEEGTDNWLAKYTILSGNDGNWFDIETDSQTNEGILK-VI-----------------
---------------------------------------------------KMLDYEKMP
NVLLSIGVKNQAEFHHSV-ASQFRMHPTPVRIQ VINVREGPMFHPSSKTFSVREGL-TGQ
SS SSRVLGTYTAIDLDTGSPATNV-----RYIIGHDAGNWLKVDSRTGEIQFSREFDKKS
KYFTNGIYKAQILA--IDD---GS-EKTATGTICIEVVDAKDYCP-VIYSERNIVCT---
N-SPSVLIYV---SDSSYGSPFTFCVLDQSPETT-PVWDIRSING--TAAI--LMTEQTL
SEQLYQVPILVKDSYNRQCELPQIVQLN--ACDCDSNHMCWQWSTTGVYNGGV------S
------------------------------------------------------------
---------------SVTDDMNGF----------VTDPGVTDSNSGLGSTGIGMIVMGLL
----LLL--LSPLLLL--------------------LC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGARPEDRD------VSHICGPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTATAMVTAEGLATGG----A-------------------A
A--GASRKRSS-TMGTLREFADP-G-------LN-VAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LVYDHEG-V--------GSPVGSIGCCSWIV-DDLDESHME
P-----LDPKFRTLAEICLDTEI-EPFPS-HQ---SCIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGTT-LSEAEFQAEMAK-TEPVVH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVLAS-PGMPDMNSVGMADA-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
R---------MV-----------------S-PDIHISQT-----IGSTSPMT-PRHRVTR
YSNIHYSPQ----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--H
VG---SGLHLQVSST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDK
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGYPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----AQGESLGGRNG
VG-----GVA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEYRSLLSGR
ATQ--VTGATGAV-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEENENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQVQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSLKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVEHSYS----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MKISATDA
DEPNTLNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSFTLDRE----EHSSYTLTVEAR
DGNGQITDKPVNQAQVQIR IL-DVNDNIPIVQNEMAE--K VEIEENQANVVVMRI---KV
FDADEIGSDNWLANYTFVSGNEMGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEIK
NLDFSITVTNKAAFH KSV-KNKYKPTSFPFKVNVKNVKEGIHFRSSTISVHVSE--SM DK
SSQGQIIGKFQAFDEDTGQVA-HV-----RYVKLEDRDNWISVNSATSEIKLVKIPDFES
RYVQNGTYTAKILA--ISE--SYP-RKTITGTIAITVEDINDHCP-TLVDPVQTVCD---
N-VPYVNVTAEDLDGSQNSGPFSFSIIDKLAGMA-EEWQIVHQES--TSVL---LQHKEL
KPGRREIQFLISDSQGLSCPEKQVLKLT--ICKCLEGGGCVEP-----------------
------------------------------------------------------------
---------------------------------------LQDSYVGLGPAAIALIILALL
----LLL--LVPLLLL--------------------MCQSGEGAK--GF------TPIPA
-T-------IEMLHP---W-NNEGAPPEDKV------VPLHVAA-----DHGVGVGTDMT
VG-----GAMTKETP---K---------ESGSAFLKGHHEVTEVD--GRWEEPRSLISGQ
VTE--GIGTTGAN-IGADGTRVMKA----T-----GSSRD---------LV---------
-G----AR-------------------AAAVPVN-EEFLRSYFT----------E---KA
ASYTDEDDIHAGKDCL---LVYSQED-T--------ESLHGSIGCCSFIE-GELDDRFLD
D-----LGFKFRTLAEICLGQKI-DMDGEIEPR--QKPVGA----------SSM-TATSH
SFSEQTRINS-------------------ENAYF--TGSSFQ-----------------V
PKP--LPE---ANTEKVTQEIVTKSSQ-SSRQSQKVATRL-PDPLASGNV-VVTETSYAA
-GSTMP----PSTAILGPGQAQALIVTERVYAPAPPSV-------------ERQ-YGNDG
SVVVT--------------------------ERIIQPNGGLPGSLEGSQPLPDAHYVMVR
ERERFLAPSLGLPSP-LAVSAA-AAGGNVTVTERVQ------------------------
-------TS----ASGYRF---PTETSQMARK-----T-----EVSGA--AVRGPLPNF-
--------------------SLEESGHLTS-------------------TRTTPSTRVSK
HSIVQHSYS----------------

------------------------------------------------------------
------------------------------MNWLPF---RAT-----GTLAILMVIV--L
VH--GE-LRIQTKGQ-HGQERTEVQ-QA------KRRYKREWVKFAKPCREREDNSKRNP
IATITSDFQATQ--KITYRISGMGIDQPPFGIFVVDQNTGEINITAI-VDREETPSFLIT
CHALNA--LGQDVEKPLILTVKI LDVNDNPPKFSQSI FMGEIEENSASNSLIMILNATDA
DEPNHVNSKIAFKIISQEPAGTPMFLLSRHTGEVRTLTNSLDRE----QVSSYHLVVSAA
DLDGEG--L-STQCECRINV K-DVNDNFPMLRESQ YS--AH-IEENTLSPELLRF---QV
IDWDEEFTDNWLAVFSFTSGNEGHWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXQVINVKEGITFRPASKTFTV QKGI -SSK
KLVNYILGTYQAIDEETGKAASYV-----RYTMGRNNGGLLIIDSKTAQIKFNKNIDRDF
TFIVNKTITAEVLA--IDE---NT-GETSTGTIYVEV PDFNENCP-TIVLE KEIICS---
S-SPSVVVSARALDSDKYTGPYTFLLEEQPFKLP-VLWTITELNA--TSAL--LRAQQPI
SPGVYRISLLVTDRQSRQCETPDSLTVE--VCQCDDRDICTSDSSDRQP-----------
------------------------------------------------------------
-----------------------------TX------XXXXXXXXXX----XXXXXXXXX
----XXXXXXAPLLLL--------------------TCDGGA-GPLGG--ATGGFIPVPD
GS-------EGTLHQ---W-GIEGAQPEDKE------ITNISAP-LIT------------
-------------------------------ANGAEL-MENSXXX--------XXTYAGG
T-V--AEGA---S--GIEMTTRLGAATGSGTSAGF------------GAATGLGTCSAGQ
S--GTIRTRHS-TGGTNRDCAEG-A-------IN-VTFLDSYFS----------Q---XX
XXXXXXXXXXXXXXXX---XXXXXXX-X----XXXXXXXXXXXXX------XXXX-XXXX
------XXXXXXXXXXXXXXXXX--XXXXXXX---XXXXXXXXXXXXX----XXXXXXX-
-XX--XXX-------------------------------------XXX------------
-----XXX-XXXXXXXXXXXXXXXXXX-XXXX-XXXXXXX-XXXXXX-XXXXXXXXXXX-
XXX-XXX-----------XXXXXXXXXXXXXXXXXXXX---XXXXXXX--XXXXXXXXSR
TVICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIISQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQEP
NIQLSIGVKNQAGFHYSV-ASQFRMHPTPVRIQVVNVREGPAFHPSTMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTG-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRV------T-------LGG--GGTADGGGSV
LGR----YALQAT------------------RALLHQHSPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------AAGVAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETFGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMVLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YA--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-IV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGSNDKVGDFVATDLDTGKPSTT---VR--YVMGNNPADLLAVDSRTGKITLKNKVTKEQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTININIQNVNGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQANTEV
---------------TNTGREES----------T-------------SSTDYETSTIYAS
SQ------------------G-----G-ASTNHNGESIPLFSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYATS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSG-LGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
-------------------------------------------------------II--N
-------FGNILLFT-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTIASGNEGNYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISVYVSE--S MDR
SSKGQIIGKFQAFDEDTGLPA-HA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLINVEDINDNCP-TLMEPVQTICH---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGDSLVGRNG
VG-----GMA-KEAT-MKG---------SSSASIAKGQHEMSEMD--ARWEEHRSLLSGR
ATQ--VTGATGAI-MTTETMKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SLYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNV-IATETSYVT
-GSTVP----PTTVILGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYIMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMKARN-----T-----MVSRA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
---------------------------------------IN------YCDCFLQVVL--E
VN--SE-FQIQARDY-NVKNGT-K-WYS------IKRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFVIY
CRALNA--QGQDLENPLALRVK VMDINDNPPVFSMTTF TGQIEENSNANTLVMKLDATDA
DEPNNLNSQIAFKIIRQEPSESPMFIINRKTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECVIKI L-DVNDNIPYLEQSS YD--IK-IEENSLHSQLVQI---RV
IDLDEEFSDNWKAVIFFISGNEGNWFEIEMNERTNVGVLK-VV-----------------
---------------------------------------------------KPLDYEATQ
NLQLSIGVRNVAEFHQSI-ISQYRITATMITVTVMNVVEGSVFRPGSKTFVINSQ-----
MGANYKVGEFVATDLDTNQIS-----TNVRYVMGNNPADLLAIGSRSGIITLRNRVTKKQ
YEMLNGRYEGTILS--IDD---NL-QRTCTGTIIIELSDTQNNSS---------------
-----------------------------------------ESG----------------
---------------------------------------------------------STS
GSGSSSEGGT-SGNTSTEETQVTTGS-----------M--NNNNN---------GDSDSY
----------------------------NNGDGDIIDRQPIGDNVHLGPAGIGLLVMGFL
----ILG--LVPFLLL--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQMP----PG-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFEMMDGVKTSAAP------------------------EICQ-DY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPEP---SWPPQSTEPMCPQQ-T--------E
PH------------------------------------------------TSG---HPPI
SPH----------YG--TTTVISENTY-PSGPGVQHPMQI-PDPLGY-GNVTVMESYTTS
-G--TLK---PSVHFHDNRQASNVVVTERVVGPISGAD-LHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTL-PAPRESSNVVVT
--ERVIQPTSSMVGN-LSMSPELSNAHNVIVTERVVSG-AGVSGISGTTGIG--------
--------GIGGISSSGL-----VSSTMGAGG----------GGLSGG---------M--
---------S-------SMGGTATIGHMRSSSDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MTCLFP---RAL-----GSLALLMVVL--L
VQ--GE-LHVKPGGQ-HREDGTALQ-LA------KRRYKREWVKFAKPCREREDNSRRNP
IAKITSDFQKNQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLILTVKI LDVNDNPPIFSQTIF KGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDRE----QISSYHLVVSGA
DNDGTG--L-STQCECSIK IK-DVNDNFPVLRESQ YS--AR-IEENTLNAELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQVQ
SMQFSIAVRNKAEFHQSV-ISQYRVQSTPVTIQ VIDVREGISFRPPSKTFTVQRGV-ST N
KLVGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAQIKFVKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTIYVEVPSFNENCP-SVVLEKKDICT---
S-SPSVTLSVRTLDRGKYTGPYTVSLEEQPLKLP-VMWTITTLNA--TSAL--LQAQQQV
SPGVYNVPVIVKDNQDGLCDTPESLTLT--VCQCDDRSMCRAPIPSREP-----------
------------------------------------------------------------
-----------------------------NT--------YGESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGS-GPIGG-AATGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PVT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-M--VEGA---S--GMEMITKLGGATGAT--------------------AALGPCSLGY
S--GTMRTRHS-TGGTLKDYA-A-P-------VN-MTFLGSYFS----------Q---KS
LAYAEEEDEREVNDCL---LIYDDEG-E----DAAPHSP--TLSSCSIFA-DDLDDNFLD
S-----LGPKFKKLAEICLGIDD-EAKQAKPG---PKDSGSGADTCAR----SMEVPQSG
-----------------------------------------------------SNRYQTL
PGSLEVTQTGSKICHTLSGNQETSVMS-TSGS-VHPAVAI-PDPLQL-GNYLLTETYST-
SGS-FAQ---PTTVTFDPHVTQNVTVTERVICPLPSAS---SSIVAPT------ELRGSY
NMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-----------------------------------------------VLFKCLQMVL--L
VY--GE-LQIEGQ---HRG--EAAGQQV------RRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDFQATQ--KVTYRISGVGIDQPPFGIFVVDQNTGDINITAI-VDREKTPSFLIT
CRAVNA--LGQDVERPLILTVKI LDINDNPPVFSQKIF EGEIEENSASNSLVMILNATDA
DEPNHLNSKIAYKIVSQEPAGMPIFLISRNTGEVRTLTNTLDRE----QISSYHLVVSGA
DKDGEG--L-SAQCSCSIK VK-DVNDNFPVLRDSQ YS--AR-IEENSLNSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
TMKFSIAVRNKAKFHHSV-ISQYQVQSTPVTIQ VINVHEGISFHPASKTFTVQKGT-SIN
KLIGYILGTYQATNDDTGKAASSV-----RYVLGRNDGGLLAIDSKTAQIKFVKNIDRDS
TFIVNKTITAEVLA--IDE---NT-GKTSTGTVHVEVPSFNENCP-LVVLEKEEICS---
S-SPSVVVSVRTLERGRYTGPYTVSLEEQPLKLP-AMWNVRTLND--TSAV--LRAQQQV
SPGVYSVSLVVKDNQGVQCDTPETLTLT--VCQCDERSRCRAPNPSRGP-----------
------------------------------------------------------------
-----------------------------YI------T-HRESSWRLGPAAIGLILLGLL
----LLL--LAPLLLL--------------------TCDCGT-GPIGG--VTSGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V--VEGA---S--GMEMTTKLGAAAGSGA------------------AAALGICSLGH
S--GTMRTRHS-TGGTLKNYVTG-P-------VN-MGFLDSYFS----------Q---KA
FACAEEEEEQDTTDCL---LIYDDEG-R----DEASCSMD-DISSCSFID-DDLDDNFLD
S-----LGPKFKKLAEICLRIND-ETQPAQAA---SRDSGPGAEACSM------EVPLSG
PNRSQTLPG---------------------------------------------------
-------------------SQGVSGPV-QSGS-VHPTIVI-PDPLQH-DNYTLTETYAA-
SGT-FVQ---PTTAAFDPRLTQNVTVTERVICPLPSVP---GSTALPT------ELRGSY
SMLYT--------------------------KE-----------LC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YEEEEMAMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRDSQ YS--AR-IEENILSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKIFTVQKGI-SS K
KLVGYILGTYQAIDEDTNKAASNV-----KYVMGRNDGGYLMIDSKTAEIKFAKNMDRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPSFNDNCP-TAVLEKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEIPGSLTLE--VCQCDNRDVCGTSYPTTGP-----------
------------------------------------------------------------
-----------------------------GT------RDGRLPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYTDG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----LTEVQQP-
------------------------------------------------------------
---------GFVKCQTLSGSQGASAFS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-ILQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVANKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISIYVSE--S MDR
SSKGQIIGNFQAFDEDTGLPA-HA-----RYVKLEDRDNWISVDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLINVEDINDNCP-TLIEPVQTICH---
D-AEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQVLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGGSLVGRNG
VG-----GMA-KEAT-MKG---------SSSASIVKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--FTGATGAI-MTTETTKTARA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINKEIEQR--QKPATE----------TSM-NTASH
SLCEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNV-IATETSYVT
-GSTMP----PTTVILGPSQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDVPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMTARN-----T-----TVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
--------------------------------WLHLH---NL-----CLLFCLLVVL--E
VN--SE-FIVEVKEL-DIENGMTK-WQT------VRRQRREWIKFAAACREGEDNSKRNP
IARIRSDCESNH--KVTYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NARGEDLEGPLELRVK VMDINDNAPVFSQNV YIASIEENSEANSLVVKVSATDA
DEENHLNSKVAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLIVRGS
DRDGAADGL-SSECDCRIK VV-DVNDNIPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTANWLAKYLILSGNEGNWFEIQTDPKTNEGILS-VV-----------------
---------------------------------------------------KMLDYEQAP
NIHLGIGVKNEADFHHSI-ASQFQMHSTPVRIQVVNVKEGPTFHPSSLTFSVPEGI-KGD
SLLNYVLGTYTAIDLDTGHPATNV-----RYIIGHDAGSWLKVHSRTGKIQFSREFDKNS
KYITNGIYTAEILA--IDD---GL-GKTATGTICIEVPDIDDYCP-DVFPHRGTICT---
D-FPSAIISV---SEDSYGSPFSFCVVDEPPGTV-DMWDIIPRNA--TSAI--LRTEQPL
LLDLYQIPIVVKDRYNRVCDSPQMVQLY--ACDCDNNHMCLDSSITGIHAGDI-------
------------------------------------------------------------
-----------------TGDIYGP----------ITEDQAEATNVGLGPAGIGMIALGAL
----MLL--LMPLLLL--------------------MC-CCKRRQPAG--LGTSFAPVPE
GG-------EGVMQT---W-RIEGAHPEDRD------VSNI-------------------
-------CVPMT-------------------ASNTQDRMDSSEIY--------NNTYAGG
GTV--EGGV---S--GVELNTGLG--TATGLLAGG------------------------A
T--GAVRRRSS-TLGTLREFADT-G-------VN-TAFLDSYFS----------E---KA
YIYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PHY---------------------------------------------------------
-----------------F-VNESSGMT-PSEAEFQAEMAA-PEPVVH-GDIILTEAYTNA
--DQCMQ---PTTIVFDPQLPPNIIVTETIMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICIPAELANTPNVIYAERILAS-PGVPDMSNSSLPED-------
--------CIGPVMSGS---------------------------------ILVGPEIQVA
Q---------VA-----------------S-PDIPTSQT-----VGSASPMT-SQHRVTR
YSTIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMERSS YD--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGNDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTGREES----------T-------------SSTDYETSTIDTL
SH------------------P-----VTSTAYQN----GVL-DNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------S--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIVLMVVL--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPFGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFSQNV YTASIEENSDANTLVVKLSATDA
DEENHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QYSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIDLSIGVKNQADFHHSV-ASQFRMHATPVRIQ VINVREGPTFHPNSMTFSVREGI-KGN
SLLNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGRWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--VDD---GS-GRTATGTICIEVPDINDYCP-DIFPDTSSICI---
A-SPSVLISV---SDHSYGSPFTFCVVDQPPGTA-DMWDIRSQNA--TSAI--LMAEQTL
SPGPYQIPILVKDSYHRVCEFAQIVQLD--ACYCDSNHMCWDSSATGIHSGDI-------
------------------------------------------------------------
-----------------TSDPYGT----------VTEDQTGVSNVGLGPAGIGMIVLGLL
----LLL---SAPLLL--------------------LMCCCKRRQPAG--LGTRFAPVPE
GG-------EGVIQS---W-RIEGAHPEDRD------VSNICVPVTA-------------
--------------------------------SNTQDRMDSSEIY--------TNTYAAG
GTV--EGGI---S--GVELNTGLG--TAAGLVAT--------------------------
---GASRKRSS-TMGTLREYADT-G-------VN-MAFLDNYFL----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-PTEAEFQEEMAL-SEPMMP-GDIIVTETYTTS
--DQCVQ---PTTIIFDPQLAPNVVVTETVMTPVYDIQ---GN-----------------
------------------------------------------------------------
----------------LCVPAELANTHNVIYAERVLAS-PGVPDMSSSSMADG-------
--------CMGPVMSGS---------------------------------ILVGPEIQVM
Q---------MM-----------------T-PDIPISQT-----GDCTSPVT-SRHRVTR
YSNIHYSQH----------------

------------------------------------------------------------
------------------------------------------------------------
----NSEFRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLERALELRVRV LDINDNPPVFSMTTFI GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEKSS YL--VS-IEENALHSELLQI---RI
IDLDEEFSDNWKAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NIQLSIGVRNKAEFHQSI-VSQYKLTATAVTVSVTNVIEGSVFRPGSKTYVVNSN-----
MGANYKVGEFVATDLDTGLQA-----TNVRYVMGNNPGDLLAIDSRSGIITLRNRVTMDQ
YRLIGRRYEGTILS--IDD---SL-QRTCTGTVIVDLDGSGWVTE---------------
-----------------------------------------TNTD--G------------
-----------------------------------------------------GTSGGTS
GG--TSGGTSSSTDTSTNSQDTGGDT-----------S--TNTEEN-TSTGGMDVNTEDM
-----------------------------NNEDRQPNTLTTADNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---PG--GGARFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQMP----PG-------
------------N-------------------VNIIEGIDNSGVY--------TNEYCGR
EMQ-DLGGGERAT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRDCRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPAGSVGCCSFIG-EDLDESFLD
A-----LGPKFKKLADISLGKEI-ESYPDPDP---SWPPQCTEPMYPQQ-T--------E
PL------------------------------------------------ASG---LPPI
SPH----------FG--TTTVISENTY-PSGPGIQHPMPI-PDPLSY-GNVTVTESYTTS
-G--TLK---PPVHLHDNLQASNVVVTERVVGPISGAD-LHGML------EMPDLREGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNSRESSNVVVT
--ERVIQPTSGMMGS-LSVHPELSNAHNVIVTERVVSG-AGVSGISGTAGIGG-------
------------VGGSSG-----LVSTVGAGG----------GG----------------
-----------------SMGGTATIGHVRSSSDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANTLVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQVVNVREGPAFHPSAMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPAIDV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSILISV---NEHSYGSPFTFCVVDEPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAYALPGGGG--TADG-GG-SV
LGR----CALQAT------------------PALLNQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAVGLMAAG----AA-----------------GA
S--GAARKRSS-TMGTLRDYADA-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DQCVQ---PTTIIFDPQLAPNVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNS--QGQDLERPLELRVRV LDINDNPPVFSMST FLGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIISQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGSDGM-SAECECSIKI L-DVNDNIPYMDLSL KS--LD-IDENALYSDLLQI---RV
IDLDEEYSANWMAVIFFISGNEGNWFNIQMNERTNVGILQ-VI-----------------
---------------------------------------------------KPLDYEAVK
NLQLSLGVRNKAEFHHSI-MSQYKLTATVITVNVQNIIEGPVFRPGSKTFVVNSN-----
MGQNYKVGDFIATDLDTGLASTN-----VRYEMGSNPAGLLAIDSKTGIITLRNRVTMEQ
YNMLNGKYQGTILS--IDX---XXXXXXXXXXXXXXXXXXXXXXX---------------
-----------------------------------------XXXX--X------------
-----------------------------------------------------XXXXXX-
--------------XXXXXXXXX---------------------X--XXXXXXXX---X-
--------X-----------X------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----XXXXXXVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CN-------DGVIHS---Y-AMEGPQPPPGN--------LTSIPQIS-------------
------------N------------------NVNVIEGIDTSGVY--------TNEFCGR
EMQ-DLGGGDRMT--GFELADGVKTTGAP------------------------EICQ-EX
X--XXXXX------XXXXXXXXX-X-------X----XXXXXXX----------XXXXKA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-ELYPDLDP---SWPPDTTEPMCPQQGT--------E
PI------------------------------------------------ASG---RPPI
SPH----------YG--TTTVISENTY-PSGPGVQHPMPI-SDPLGY-GNVTVTESYTTS
-G--TLK---PSVHIHDNRHASNVVVTERVVGPISGAD-LHGML------EMPEMRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-PDPRESSNVVVT
--ERVIRPTSGMMGS-LSMHPELSNAHNVIVTERVVSG-SGVTGISGPAGIIG-------
---------GSGTVSSGL-----VGS--------------------AA--GVNAGGIGMS
-----------------SLGGTASTGHMRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWHSLR--TA------AVLLIFLVVV--E
VN--CE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNS--QGQDLERPLELRVRV LDINDNPPVFSMTTFL GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIISQQPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGL-SAECECNIKI L-DVNDNIPLLELSS YS--VS-IEENALNSELLQI---RV
IDLDEEYSANWVAVPFFISGNEGNWFDIVMNERTNVGFLR-VI-----------------
---------------------------------------------------KPLDYEDMK
NLQLSIGVRNKAEFHHS I-MSQYKLTATAISVTVLNVVEGSVFRPGSK TFVVTSN-----
MKANSKVGEFVATDLDTNLPSTS---V--RYVMGNNPADLLSIDSRTGVITLRNRVTMEQ
HEMLRGRYQGTILS--IDD---SL-QRTCTGTVIINLDGSGWVSG---------------
-----------------------------------------TETN--T------------
-----------------------------------------------------GSNTGSE
TGGGGE-----TGTNAGTNTG------------GTSTNTDTNTNTN-TNENNGGGTIGGT
DENSSTNENT-----NTNTNA------GDGETSGYDGRQRLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLL--------------------CCDCGGA---SG--GGAGFEPVPE
CS-------DGAIHP---W-AVEGPQPEPT------GLATICVPQMP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNDYCGR
EMQ-DLGGGERTT--GFELMDGVKASGAP------------------------EICP-EY
P--GTLRR------SSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDT-ESYPDPDP---AWPPQSTEPMFPQQGP--------E
PV------------------------------------------------SNG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-SDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNRHASNVVVTERVVGPISGTD-LHGIL------EIPDLREGS-
NVIVT--------------------------ERVIAPGSSLPTSLTV-SNPRESSNVVVT
--ERVIQPTSGMMGS-LSMHPELSNAHNVIVTERVVSG-AGVSGISGTAGIS--------
--------GGGGLSSSGL-----VGTSMGAGG----------GGLSGA--GISSGGIGLS
SLGG-------------GVGGTATIGHMRSSSDHHFSQT-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVTTRTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYTDG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-ESKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DMENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGVGIDRPPYGVFAINPQTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVKV MDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECACRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLNSELIRL---KA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIHLSIGVKNQAEFHHSV-ASRFRMHSTPVRIQV INVREGPIFDPNS MTFSMREGV-RGD
SLLNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGNWLKVDSRTGEIQFSREFDKKS
KYITNGMYTAEILA--VDD---GS-GKTATGTICIEVPDVNDYCP-VIFAESETICI---
A-SPSILISARDVNHHSYGSPFTFCVVDQPPGTA-DLWDIKSINA--TSAI--LTAEQPL
LARTYQVPVLVKDSYNRACELPQMVQLE--ACDCDTNHMCLYSSTTGIYTGAS------S
------------------------------------------------------------
---------------SVTNDIYGP----------VPNDRIERSNVGLGPAGIGMIILGLL
----LLL--LAPLLLL--------------------ICCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-GIEGAHPEDQV------SSPYLLFC--G--GGMAERSN-S
GLH----GTTQTT------------------QALLCEHPLLTEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLAAGG------------------------A
V--GTLRRRSS-TLGTQREYADT-G-------TN-MAFLDSYFS----------E---KA
YVYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-EDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAI-PEPMIH-GDIVVTETYTTA
--DQ--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------LIHLLSRQEII------LIYLLIKVLV--E
VN--SE-FRIQVRDY-NAKNGTIK-WHS------IRRHKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPFGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNL--QGQDLERPLELRVRV LDINDNPPVFSMSS FLGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIISQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SADCECSIKI L-DVNDNIPYLEGSS YQ--IE-IEENSLNSNLLQL---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIAMNERTNVGTLR-II-----------------
---------------------------------------------------KPLDYEAMK
NLQLSIGVRNKAEFHQSI-MSQYKLTATAISVTV LNVIEGSVFRPGS KTFVVTSN-----
MGQNYRVGDFIATDLDAGGPSTK---VRYRYVMGNNPADLLSVDSKTGIITLRNQVTMEQ
YNMLNGKYQGTILS--IDD---GL-QRTCTGTINIDLQGSGWKTS---------------
-----------------------------------------ETTP--K------------
-----------------------------------------------------YNTDSEG
G----TGTGGGTGELTTGEVTVN-----------------T-------ESNNGN------
----------------GNVDG-----GVTDDYKEPLGVPMFPDNVHFGPAGIGLLVMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------EGVIHP---W-AMEGPGPEPGI-----IT-TIPVPQIP----PG-------
--------------------------------GNIIQCVDTSGVY--------TNEYGGR
EMQ-EIEGEERMT--GFELEDGVKSSGAP------------------------EICQ-EY
S--GTLRR------NSMRECRE--G-------LN-MDFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDFDDSFLD
T-----LGPKFKKLADISLGKNV-ESYPDFDL---PWP-ESTEPIFPQQGT--------E
PV------------------------------------------------ASG---RPPT
SPC----------YG--TTTVISESAY-PSGPAVQHPMSI-PDPMSY-GNVTVTESYATS
-G--TLK---PSVHIHDNRHASNVVVTERVVGPISGAD-LHGML------EMPDLREGS-
NVIVT--------------------------ERIIAPGSSLPATLTI-PDPRESSNVVVT
--ERVIRPTSGMMGG-LSVHPDLSNAHNVIVTERVVSG-SGVTGFSGPAGS---------
--------------------------------------------LVEA--GIGGGGIGLS
SLGGGGGLSS-------SMGGTATIGHMRSSSDHHFSQT-----LGSTSPST-ARSRITK
YSSVQYTK-----------------

------------------------------------------------------------
------------------------------MDWSLYRTTAV------LFILGVV--V--E
IN--SE-FRIQVRDY-NTQNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAKDQ--QVTYRISGVGIDQPPYGVFIINPKTGEINITSI-VDREVNPYFKIY
CRALNA--HGQDLENVLELRVKV LDINDNPPIFSMTE FAGSVEENSYANTLVMVINATDA
DEPNNLNSKIAFKIVSQDPPDSPMFILNRYSGELRTMNPFLDRE----KYSMYSLVIRGS
DRDGGADGL-SAQSDCKITI L-DVNDNFPXXXXXX YT--IN-IQENMVSQEVTRF---KV
IDLDQEGTANWLALFFFISGNEGGWFEIVTDEMTNEGIFR-VI-----------------
---------------------------------------------------KPLNYEEMQ
NMQLSIGVRNQAEFHHSV-ISQYKIEATVITVNV ENVIEGSVFAPASKT YIITKT-----
MGKNSVVGSMVATDLDTGGPSKT-----VRYIMGTNPGGVLAVNERTGQLTLNNVITREL
YQRLHGQYEGTLLS--IDD---NL-QRTCTGTIILDLSGLDYGNG---------------
-----------------------------------------GGTG--G------------
-----------------------------------------------------ETKMEMA
A--GGQGGGTS---TTREDTTTN---------------------SN-G-DTY--------
-----------------TD---------SWHIYAGGGEESVGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------ACDCGGA---SG--VGGGFEPVPE
CS-------EGAIHT---W-AVEGPQPDXXX----------XXXXXXXX-----------
------------X------------------XXXXXXXXXXXXVY--------TNEYGER
EMRDLGEGGMGTS--RFELSNGVKTSAVP------------------------EVCT-GH
F--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
FAYADEDESRPSNDCL---LIYDIEG-V--------GSSAGSIGCCSFIG-EDEDDSYLD
A-----LGPKFKKLADISLGKEI-DPYPDFDH---AWPPETTEPSCPPQGN--------D
IS-------------------------------------------------IG---HPPK
SPH----------FG--TTTVVSESTY-PSGPGIQHPMAI-PDPLSY-GNVTVTESYTTS
-G--SLQ---PPAHIHDPRHGSNVVVTERVVGPISGSD-LQGML------DLTDFREGS-
NVVVT--------------------------ERVIAPNSRLPTSLSI-PDPRDTSNVVVT
--ERVIRPTSGLMGN-LSIHPELSNAHNVVVTERVVSG-SGVTGISGGG-VSG-------
--------VVGSNVSRGAVTMSGGGVNMSG-----------------A--GISGSGIEMS
SLG-----------------GVASIGHVRNS--DHFNQT-----VGSASPST-TRSRITK
YSTIQYSKQ----------------

------------------------------------------------------------
------------------------------MNWFFF---RTT-----GALAILMVIV--L
VH--GE-LRLETKSQ-HGEDEMAVQ-PA------RRRYKREWVKFAKPCREREDNSKRNP
IAKISSDFQANQ--KIFTTISGMGIDEPPRGIFVIDENTGEINITSI-VDREQTPSFQIT
CRAINI--HGREMERPLVLVVKI LDVNDNPPVFSQSV FMGEIEENSASNSLVMILNATDA
DEPNNLNSKIAFKIISQEPAGMPMFLLSRHTGEVHTMTNTLDRE----QVSSYRLVVSGA
DRDGEG--L-SSHCECSIKVK-DVNDNFPIFKESQXX--XX-XXXXXXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XALDYEQLQ
KVQLSVAVRNKAEFHHSV-ISQYKVQSTPVTIQV INIKEGIAFHPASKT FTVQKGI-SSK
KLVNYILGTYQAIDEDTRKVSSSV-----RYIMGRNNGGLLTVDSKTGQIKFIKNIDRDF
SFIHDKTSTAEILD--IE----TT-GQTSTGTIYVKVPDFNENCP-TIVFSEDVICS---
S-SSSVVVSARALDRDRYTGPYTFSLEEQPQKLP-VLWSITALNX--XXXX--XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX-----------
------------------------------------------------------------
-----------------------------XX------XXXXXXXXXXXXXXXXXXXXXXX
----XXX--XAPLLLL--------------------MCDCGS-GGVGG--VTGGFIPVPD
GS-------EGTIHK---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------SDGVDF-MENSEVC--------TNTYAGG
T-M--GEGA---S--GMELTPRPGPAVGAGAAGGFG----------------ATICSGGQ
S--GTVRTRHS-TGGSNRDGGDG-A-------VN-MHFLDSYFS----------Q---KV
LVCAEEDDGQEANDCL---LIYDNE--G----MGGSGSPVGSLGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGLGA-EDQQFQLP---TNGRDSGIESCGY----AVGIQKQ-
------------------------------------------------------------
---------GSDRCQTLSGSQGSTLVH-TCSSTFQPAISI-PDPLQG-GSYLVTETYKT-
TGP-LLQ---PSPAVCDPLITQNITVTERVICPITNVP---GNVQGAT------EVRGSC
NMVCA--------------------------ED-----------HC--------------
--SLLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHSIR--AA-------VLLIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECNIRI L-DVNDNIPYMEQPS YS--TS-IEENALHSNLLQI---RV
IDLDEEYSANWVAVIFFISGNEGGWFDIEMNERTNVGILK-VI-----------------
---------------------------------------------------KPLDYEAMQ
TMQLSLGVRNKAEFHSSI-MSQYKLTATAVTVAVSNVIEGSVFRPGSKTYVVTSN-----
MGQNYKVGDFIATDLDTGSASTT---V--RYVMGNNPANLLDVDSKTGIIILRNRVTWEQ
YKMLGGKYQGTILS--IDD---NL-QRTCTGTINIDLQGSGWAEK---------------
-----------------------------------------DINS--G------------
-----------------------------------------------------TNSGTSG
GSEGTSGGSEGTSGGSEGTSGGSEGTSGGSGSTGGSSTENMEGGGE-TSTEYGTE-----
----------------T-----------QTMEGGEGVGANLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLM--------------------CCECGGA---PG--GGAGFEPVPE
CS-------EGALHT---W-AVEGPQLPP--------D-TVCVPPIS----PP-------
------------G-------------------ANLIECIDTSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTEGVKTSGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEV-EPYPDPDP---SWPPEGTEPICPQQGT--------D
PI------------------------------------------------TGG---HPPI
SPH----------FG--ATTVISESTY-PSGPGVQHPMPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PSVHIHDNRHASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NIIVT--------------------------ERVIAPSSSLPTSLTM-PDPRESSNVVVT
--ERVIRPASGMMGN-LSIHPELSNTQNVIVTERVVSG-SAISGISGPAGMT--------
--------GGSGLVG------------------------------SVA--GGSGGGIGLS
SLGGGGGLSS-------SMGGTATIGHMRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MVGIFP---RIT-----EALVILMVVM--L
VH--GE-LRIETKGQ-HKEDETAVQ-QA------KRRYKREWVKFARPCREREDNSKRNP
IAKITSDYQANQ--KITYKISGVGIDQPPFGIFVVDPNSGDINITAI-VDREETPSFLIT
CRALNA--LGQDIEKPLILTVKI LDVNDNAPVFSQSIF TGEIEENSAANSLVMILNATDA
DEPNHQNSKIAFKIVSQEPAGIPMFLLSRNTGEVHTLTNSLDRE----QVSSYHLVVSGA
DRDGEG--L-SSQCECSIK VK-DVNDNFPMLKDSQ YS--AR-IEENTLSSELLRF---QV
IDWDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KPLDYEQLQ
NIQLGIAVKNKAEFHQSI-ISQYRVQSTPVTIQ VINVKEGIAFRPASKTFTVQKGI-SSK
KLVDYVVGTYQAIDEETGKAASYV-----KYIMGRNNGGFLTIDSKTAEIKFVKNMDRDS
TFIVNKTITAEILA--IDG---NT-GRTSTGTIYVEVPSFNENCP-TIVLEKEIICS---
S-SPSVVVSVRTLDRGKYTGPYTFSLEKQPLKLP-VVWSITTLNA--TSAL--LRAQQEI
SPGVYRVSLVVTDNQNNICEMPESLTLE--VCQCDNRGICRSYKPNRDP-----------
------------------------------------------------------------
-----------------------------EI------KYGKPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGT---TGV--VPGHFIPVPD
GS-------EGTIHQ---W-GIEGAHPQDKE------ITNICVP-PIT------------
-------------------------------TNGGDF-MESSEVC--------TNMYAGG
T-V--VEGA---S--GMEMTTKLGAASGSGGAAGFAAGTVSSAAAGFGAATGLGICPAGQ
S--GTMRTRHS-TGGTNKDYGNG-A-------IS-MSFLESYFS----------Q---KA
FACAEEDDNQEANDCL---LIYDNE--G----VDDSDSPLGSLGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDD-EATHAQPR---PKDSGYGTE-----------APQS-
------------------------------------------------------------
---------GSVRCQTLSGSQGTLAQQ-GSGS-FQPAVPI-PDPLQP-GSYLVTGTYSA-
SGT-LVQ---PSTAVFDPLLTQNVTVTERMICPISSVS---GNLAGQT------QLRGSR
SMLYP--------------------------ED-----------PC--------------
--PRPI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLAL---RTV-----GVLVILMVVV--E
VN--CT-FWVEVKGQ-NEEDGTALQ-KP------LRRYKREWVKFAKPCREGEDNSKKNP
IATISSDYQKHQ--KITYRITGKGIDQPPYNVFVVNPRTGEINITQI-VDREATPMFLIT
CQALDE--WGRDVENHLVLTVKI LDINDNLPVFSQSTFL GEIEENSAANTLVMVINATDA
DEPNHLNSKIAFKIISQEPVGQPMFLLNRLTGEVRSMTSTLDRE----KNSKYSLVVSAA
DLDGAG--Q-AIECACQII IK-DVNDNFPIFRESQ YS--IQ-IKENTLSSEVIRF---QV
TDLDEEFTDNWLADYFFTSGNEGKWFVIETDPKTNEGILK-MV-----------------
---------------------------------------------------KTLDFEQFQ
TMELGIAVRNKAPFHQSI-ISQYRIHSTPVRVQIINVKEGIAFHPTSKTFEVQKGI-SYK
KLINYVVGTYQAIDEDTGKPASFV-----RYELGRNDGGFLAIDSKTAQIKFIKNLSRDS
TFIVNKTITAEILA--IDD---NT-GKTSTGTIIVRVPDFNENCP-KVTTDRVTVCR---
T-SGSVIVTAKPLQNQPDTGPFTFSVVQQPMRTP-VTWSVTTINT--TSAK--LETQQTL
SSGTQSLSLLVTDRQGMSCEILETLELQ--TCDCDENQRCVSVVPFPD------------
------------------------------------------------------------
-----------------------------------GNRQKGGPSVSLGPAAIGLIFLGLL
----TLL--LVPLLLL--------------------FCNYGA-GGIGG--VGSGFIPVPD
GS-------EGTIHQ---W-GIEGAQPQDKE------ITNICVP-PIT------------
-------------------------------ANGTEF-MESSEVC--------TNAYATG
T-V--VEGT---S--GIELTTRLRAASGSAGTTGL--------------------VGAGH
S--GTMRTRHS-TGGTIREYAEG-T-------VN-MNFLDTYFS----------Q---KA
FACADEDDGQGVSDCL---LIYDDE--G----IEAPSSPVGSVGCCSFIA-DDFDDSFLD
S-----LGPKFKKLADISMGIDD-EPKPSQAP---EKTNIAVPGTSGSQS-------ASA
PSTHGTCPPT------------------------------------INVTC---------
----------PPA---TFYSNEPSTLP-ASGSVFQPAIPI-PDPLLQ-GNFLVTESYTT-
SGS-FTQ---PSTIVFDPRLTENVTVTERVICPISGVSGIQGNLNGPT------QLGGSC
NVTCT--------------------------QD-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NM-----SFLIILMVLL--E
VN--SE-FIVEVKEF-DVENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLEKPLELRVKV MDINDNRPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRNTGEVCTMSSFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECECRIKV L-DVNDNFPVLEKTF YT--AS-IEENCLSSELIRF---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIETDPRTNEGILK-VV-----------------
---------------------------------------------------QMLDYEQMP
NIYLSIGVKNQADFHHSV-ASQFQMHSTPVRIQV VNVREGPAFHPDS MTFSVREGL-RGN
SLSNYVLGTYTAIDLDTGSPATNV-----RYIIGHDAGNWLKVDSRTGEIQFSREFDRKS
KYITNRIYTAEILA--IDD---GS-GKTATGTVCIEVPDVNDYCP-VIVAERETICI---
A-SPSILISATGMDDHPYGSPFTFCVVDQPPGTA-DSWDIRSINA--TSAI--LTAEQTL
YPSYYEIPILVKDNFNRACELPQILQLL--ACDCDSNHMCLYAGTTGISTGDGSSVTGV-
------------------------------------------------------------
-----------------------S----------VTDDHVEGSNVGLGPTGIGMIILGVL
----LLL--LTPLLLL--------------------MC-CCKSKQPEG--LGTRFAPVPE
GG-------DGVMQA---W-RIEGAHPEDRR------PSTASRLCGCG--GGGAADSA-G
SLR----GTMQ-A------------------TPALYEHPLLSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGPG--AAAGLVAGG------------------------A
V--GTARRRSS-TPGAQRDYADP-G-------LH-LAFLDSYFS----------E---KA
YDYAYEDEGQPANDCL---LIYDHEG-L--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDKEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSQAEFQAEMAT-PEPMIH-GDIVVTETYTTA
--DPCVQ---PTTIVFDPQLAPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELASTHNVIHAERVLSS-PGLPDTSSSSMTDG-------
--------CVGPVMSGS---------------------------------ILVGPEIQMM
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRHRVTR
YSNVHYSQQ----------------

------------------------------------------------------------
---------------------------------MSGAWWWPPV-IQLLRKLRQEKCL--N
PG---GRD----TIL-LNGNNLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEEGGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALNE--RGVNIEKPLELRIKVLDVNDNEPVFTQDVFFGSVEELSVANTLVMKINATDA
DEPNTLNSKISYRIVSVEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGQVTDKPVKQAQVQIR IL-DVNDNIPVVENKMLE--GM-VEENQVNVEVIRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEIK
NLDFSIIVTNKAAFHKSI-RSKYKPTSIPIK VKVKNVKEGIHFKSDVITIYV SE--SMER
SSKGQIIGKFQAFDEDTGLLA-SA-----RYVKLEDRDNWISLDSVTSEIKLAKIPDFES
RYVQNGTYTIKILA--ISE--DDL-RKTVTGTIRIAVEDTNDNCP-TLTEPVQTVCN---
D-AQYVNVTAEDLDGYPNSGPFRFSVIDKPPGMA-EKWKIVRQER--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------HRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQRDSLAGRNG
VG-----GMA-KEAT-MKE---------SSSGSFAKGQREMSELD--GRWDEHRSLLSAR
ATQ--VTGATGAI-ISKETMKNTRA----T-----GASRD---------VA---------
-G----AQ-------------------TAAVALN-EEFLGNYFT----------D---KA
ASYTEEDENHIAKDCL---LVYSQEE-T--------ESLNASVGCCSFIE-GEQDDRFLD
D-----LGLKFKTLAEVCLGQKI-DIDMEIEQR--QKRATE----------TSM-NTASR
SLYEQTMVNS-------------------ENT-S--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASGNM-MATEASYAT
-GSTKP----PSTVILGPRQPQSLIVTERVYAPASTWV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGPNPLEGTQHLQDAHYVMVR
ERESFLAPSSGVQPT-LAMPNL-AVGQNVTVTERVL------------------------
-------APASTLQSSYLI---PTENSLKVRN-----T-----MVSGA--AVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWSFFR--VV------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WYS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYALAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--IE-IQENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSIGVRNKAEFHHSI-MSQYKLTASAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGSNDKVGDFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTKEQ
YNMLGGKYQGTILS--IDD---NL-QRTCTGTININIQSFGNDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TEPNTKI
T--------------TNTGRQES----------T-------------SSTNYDTSTISTD
SS------------------Q-----VLSSKPGHGANDLFLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----IT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLRGGERMT--GFELTEGVKTSGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHAKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHIHDNRPASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTASIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCELNQ--KITYRISGVGIDRPPYGIFTINPRTGEINITSV-VDREITPLFLIY
CQAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLSATDA
DEENHLNSKIAYKIVSQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFNIQTDPETNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
TIQLGIGVKNQADFHYSV-ASQFRMHSTPVRIQVINVREGPTFHPSSMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPANNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-DITPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LMAKQFL
SPEFYQIPILVKDSYNRACESAQIVQLR--ACDCDDNHMCLDSSTVGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------ITEDQAGVSNVGLGPAGMGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-GIEGAHPEDRD------VSNICAPMTAS------------
---------------------------------NTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGLG--TAAGLVAG------------------------GT
A--GATRKRSF-TVGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VSESSGLT-PSEAEFQEEMAA-SEPVIH-GDIIVTETYGAA
--DQCVQ---PTTIIFDPQLAPNVVVTETLMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNIVYAERVLAS-PGVPDMSNISTTDG-------
--------CMGPMMSGG---------------------------------VLVGPEIQVM
Q---------MM-----------------S-PDIPISQT-----VGSTSPMT-PRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MMGLLP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKDQ-YDEEEMTTQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SMKFSIAVKNKAEFHQSV-ISRYRVQSTPVTIE VINVREGIAFRPESKTFAVQKGI-SSN
KLVDYILGTYQAIDEDTRKAASNV-----KYVMGRNNGGYLMIDSKTAEIKFVKNVDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPSFSDNCP-TAVLDKDEICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-VIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSSPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYSRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-V--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MACLFP---RAL-----RLLSLLMVVL--M
VY--GE-LHIESGGQ-HREDRMALQ-LT------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQKNQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLILTVKI LDVNDNAPIFSQTIF KGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGMSMFLISRNTGEVRTLTSSLDRE----QVGSYHLIVSGA
DNDGTG--L-STQCECSIK IK-DVNDNFPVLTDSQ YS--AR-IEENTLNSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-LV-----------------
---------------------------------------------------KVLDYEQMQ
SMQFSIAVRNKAEFHQSV-ISQYQVQSTPVTIQ VINVQEGISFRPPSRTFTVQRGV-SIN
K LAGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGFLVIDSKTAEIKFVKNINRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVYVEVPSFNENCP-SVVLEKREICT---
S-SPSVTLSVRTLDRAKYTGPYTVSLEEQPLKLP-VVWTITTLNA--TSAL--LQAQQHI
SPGVYNVPVIVKDNQDGQCDTLESLTLT--VCQCDDRSMCRAPGPSREP-----------
------------------------------------------------------------
-----------------------------FI--------REESTWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGS-GPIGG-AGTGGFVPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PVT------------
-------------------------------SNGADF-MESSEVC--------TNTYAGG
T-L--VEGA---S--GMEMTTKLGGATGSG--------------------AA-VALGLGH
S--GTMRTRHS-TGGTLKDYA-A-P-------VN-MTFLGSYFS----------Q---KS
SAYAEEEDDREVNDCL---LIYDDEG-E----DAAPRSP--ALSSCSFMA-DDLDDSFLD
S-----LGPKFKKLAEICLGVDD-EAKQVKPG---PKDSSSGADACAR----PTEALQAG
SNRYQTLPGSLEVTQSGSSRYQTLPGG-L-EVTQSGSNRYQTLPGGLEVTQSGSNRYQTL
PGGLEVTQSGSKVCHVLPGNQDTSVLS-SSGS-VHPAIAI-PDPLQL-GNYLLTETYTT-
SGS-FVQ---PTTATFDPHVTQNVTVTERVICPLPSAS---GSIVAPT------ELRGSY
SMLYT--------------------------KE-----------AC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWNSFR--TA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WNS------IRRQKREWIKFAAACREGEDNSKRNP
IARISSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPYFIIY
CRALNS--MGQDLERPLELRVKV LDINDNPPVFSMSTF VGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIISQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEMSS YS--VN-IEENALHSDLLQI---RV
IDLDEEYTANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEEIK
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVVVLNVVEGSVFRPGSKTFAVTSN-----
MGANHKVGEFIATDLDTGSASTT---V--RYVMGNNPADLLVVDSKTGIITLRNKVTKDQ
YDRLGGKYQGTILS--IDD---SL-QRTCTGTVIIDLQGSGWETS---------------
-----------------------------------------NEGG--G------------
-----------------------------------------------------TSGGSSS
GGDGGTSTSGDTGSNTETSTGTD----NNQGREDTST----NTNEN-GSTDSGTPN----
-------TQG-----NDNGEP-----TEYVPNENSGGRGIPSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCECGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----MT-TVCVPTIP----PT-------
------------N-------------------VNMIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGREI-DSYPDPEP---SWQPQSTEPPCPQQTT--------E
PM------------------------------------------------VGG---HPPV
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-PDPLGY-GNVTMTESYTTS
-G--TLK---PSVHLHDNRHASNVVVTERVVGPISGAD-LHGML------DIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-SNPRESSNVVVT
--ERVIQPTSGMMGS-LSMHPDLSNAHNVIVTERVVSG-AGISGISGTGGIS--------
--------GGGGIGSSGL-----VSTSMGAGS----------MGMSGA--GVSGGGIGLS
NLGGGGGLSS-------SMGGTATIGHVRSSSDHHFSQT-----LGSASPST-SRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MARSPGRPCAL---------LLLLVCF--N
FG---NGLHFEALNT-RNENKPLAK-HA-----H-ARYKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERQLKITYKYTGKGITEPPYGIFVYNKDTGELNITTI-LDREETPFFVLT
GYALDS--RGNNLEKPLDLRIKVLDINDNEPVFTQDIFVGSIEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSQEPANPPVFYLNKDTGEIFTTSIALDRE----EHSSYTLTVEAR
DGNGQITDKPVKQAQVQIRV L-DVNDNIPVLEKEM YE--GT-VEENQANVEVIRI---KV
FDEDEIGSDNWLANFTFVSGNEKGYLHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KELDYEEMK
ALNFSIIVTNKAAFHKSI-RNKFKPVAIPIK VKVINVKEGIYFKSDTIHVRAGE--GMDI
TSQ SQTLGTFQAFDEDTGQPA-RA-----KYIKFEDADNWVSVDSATSEIKLVKVPDFES
RYVQNGAYTVKVVA--VSE--DLP-RKTITGTVSIMVEDINDNCP-TLVEPVQTVCD---
D-VPYVNVTAVDLDGYPNSDPFTFVVIDKPPGMA-ERWKITKQES--TSAL---LQQSER
QLGRSEIQLLISDSQGLSCPEKQVLQLT--VCQCQNGLGCAAM-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAVALIILALL
----LLL--LVPLLLL--------------------ICHCGNGAK--GF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLAV-----DHGENLAARNG
VG-----SMSTKEAT-MKG---------SSSASFTKGQHEMSEVD--TRWDEHRSLLSAG
ATQ--VMGPAGAG-LGTETMKTVRA----T-----GASRD---------AV---------
-G----AR-------------------AAAAGLN-EEFLRSYFT----------D---KV
ASYAEEDDIHTAKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-GTDLEIEQR--QKPVPA----------PRV-NTASH
SLYEQAVVNS-------------------ENAYS--SGSSFQ-----------------V
PKP--LHE---ASAETVTQEVVTERSV-SSRQGQKAAAPL-ADPLASGNI-IVTETSYAT
-GSAVP----PSTVILAPRQPQSLVVTERVYAPASSLV-------------DQH-FANEG
NVTVT--------------------------ERVIQPNGGIPHPLDGTQHLQDAHYVMVR
ERESILAPSSGVQPT-LAMPSV-AAGQNVTVTERVL------------------------
-------A-PTALQSSYQM---PSEASVMTRK-----T-----MVSGAGAGASGPLPTF-
--------------------GLEESGQSNS-------------------TVTTSSTRVTK
HSTIQHSYS----------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------LVRQKREWTVPPAFIREEEDNSYKNP
IARIHSDL-EDTGIVVTYTISGQGVTQPPYGLFVINGKTGDLNITGR-VDREKTPMLLVR
GHALDK--NGAKLEEPIDLPIKVVDINDNFPVFSQEVFVGSVEELSETGTIVMRINATDA
DEPNNLNSKIAFRIVSQSPS--TPFIIDKNTGEVRVAIINLDRE----TQSSYSLVVEAK
DRGGEKDGN-AATCSLEIK IL-DVNDNLPVVESRTFE--AS-IEENRANVEIMRI---KV
FDKDEEFSDNWLANFTFVSGNEGGFFKIVTDTQTNEGILT-VV-----------------
---------------------------------------------------KELDYEKMQ
SLNLGIVVTNKAEFHK SI-KASYKAETIPIKIKVINVKEGPVFPGGTKI IEASEK-----
TQIKQVIGQYQAYDEDTGKIAEHI-----TYMKGKDAANWITVDSVTGEILLAKNLDYES
LHVVNGTYTITMLG--VTT--DSP-RKTITGTVVIQVKDENDNCP-VIVNPVRTVCS---
D-AQVVDVTANDLDGYPNSYPFSFTVIDEPEGTA-AKWIIASRND--TSIQ---LVPQNL
KPGRTEVPILIKDFQGVSCALPQSLQLT--VCGCADRGVCQEK-F---------------
------------------------------------------------------------
---------------------------------------VGSNSVGLAPAAVALIILAFL
----LLL--LVPLLLL--------------------LCPGGLGAK--GFT----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQEP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQVVNVREGPAFHPSTMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIGSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRV------TLSVSFLALGG--GGTADGGGSV
LGR----YALQAT------------------RALLHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------AAGVAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDETCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETFGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVLAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---QVVDSDRPE--GSKFRLTGKGVDQEPKGIFRINENTGSVSVTRT-LDREMIATYQVS
T-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-----------------------------CRDRPAPRFWMI------LLASVGVVCL--D
FG---NGLHFEVFST-SKEDKLVPK-HS-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDKNTGNLNVTSI-LDREETPYFLLT
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFQQDVFVGSIEELSAAHTLVMKVIATDA
DDPTTRNAEIAYRIVSQEPANTPVFYLKKDTGEIYTTSFTLDRE----EHSSYSLIVEAR
DADGQITDKPVQQAQVQIQI L-DVNDNIPVVENKL YE--GV-VEENQVNVEVMRI---KV
TDADEIGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMK
DLNFSIVVTNKAAFHKSV-RNKFKPTPIPIT VKVKNVVEGIHFKSNVVSVRASE--AMDR
SSLSQSIGKFQVFDEDTGQAA-KV-----KFAKVEDIDNWVSVDSATSEIKLVKIPDFES
RYVQNGTYTVKVVA--ISS--DHP-QKTITGTVVITVEDSNDNCP-TLVEPVQSICK---
D-APYVNVTAKDLDGPQNSGPFTFSILDQPSGTA-EQWKIVHQEG--TSVL---LRQSEW
KLGRSEVPVLISDSQGFSCPEMQVLQLT--VCECLKGGGCAAA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------LCHCGEGAK--GF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVA-----DHAENSAVRNG
LG--GAGGAMIKESL-VKG---------SSSASFTKGQHEMSDMD--GRWEEHRSLLTAG
ATH--QVGTAGVI-AANETLRITRA----T-----GASGG---------MS---------
-G----AR-------------------GAAVAMN-EEFLRSYFT----------E---KA
ASYAEDDDLHMAKDCL---LVYSQEE-T--------DSLRGSIGCCSFIE-GERDDLFLD
D-----LGLKFKTLAEVCLGRKI-NLDVDIEHR--QKPVQE----------ASV-KPASG
SHYEQMTVSS-------------------ESTYS--SDRGFQ-----------------V
SKP--LPE---AHTEKVMQEIVTESSV-SSRQSQKVVPPA-PDPVASGNI-IVTETSYAT
-GTTGP----PSTVILGPRQPQSLIVTERVYAPAATLV-------------DQH-YANGE
NVVVT--------------------------ERLIQPNGSVPKPVEVTQHLKDARYVMVS
ERESILAPSPAVQPT-LVMPSV-AAGQNVTVTERVV------------------------
-------TPASTLQSGYQI---PSETSLKARK-----T-----VVSSV--GGLGPLH---
--------------------SSEESGHHNS-------------------TVTTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIKVKVKNVKEGIHFKSSVISTYVSE--SMDR
SSKDQIIGKFQTFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDEPPGMA-EKWKIAHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAITLMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFTKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--VTGATGAI-MTTETAKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAADALN-EEFLRNYFS----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATV----------TSM-NTASH
SPYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVLGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MNWPFFR--AA------VVLFIFLVVL--E
VN--SD-FRIQVRDY-NTKNGTIK-WHS------LRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLEKPLELRVRV LDINDNPPVFSMSTF VGEIEENSNANTLVMVLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMELPTQS--IS-IEENSLNSNLLQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDFEAMN
NLQLSLGVRNKAEFHQSI-MSQYKLTATAISVTVLNVVEGSVFRPGSKTFVVNSN-----
MGQNYKIGEYVAWDLDANRPSTT---V--RYVMGRNPTDLLAIDSKTAIITLRNKVTMEQ
YKILGGKYQGTILS--IDD---AL-QRTCTGTIVINLENGGWKTE---------------
-----------------------------------------RPNV--N------------
-----------------------------------------------------GSTTSAY
SLTSG---GVTTNGYIT-GVG-----------------------GG-ANTLAVG------
-------T-------------------SV-YVREPDTYQTIGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLM--------------------CCDCGGA---PG--GGAAFEPVPE
CS-------DGAIHS---W-AVEGAQADPGV-----LA-SSAVPCIP----AT-------
------------N-------------------ANVIEYVDNSGVY--------TNEYGAR
EMQ-DLGGGERTT--GFELTDGVKMSGGP------------------------EICQ-EY
P--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDV-EPFPDSDP---SWPPESTEPVCPPQGT--------E
PT------------------------------------------------GGG---HPPI
SPR----------FG--TTTVISENTY-PSGPGVQHPTPI-PDPLGY-GNVTVTESYTSS
-G--TLK---PSVHIHDNRHASNVVVTERVVGPISGAD-LQGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTTLTI-PDPRQSSNVVVT
--ERVIQPTSGIVGN-LSMHPELSNTHNVIVTERVVSG-SGITGSSSLLG----------
---------------------------------------------SAG--GGSGGGIGLG
SLGGGGGLSS-------SLGGAATIGHLRGSAEHHFSNT-----LGSASPTT-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MTCPFP---RVL-----GPLALLMVM----
----RS-LSTQPGGQ-HREDGTAVQQ-V------RRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDPNNGDINITAI-VDREETPSFLIT
CRALNV--LGQDVEKPLILTVKI LDVNDNAPIFSQTIF QGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKLVSQEPAGMPMFLISRNTGEVRTLTSSLDRE----SIGSYRLVVSGT
DNDGAG--L-STQCECSIK VK-DVNDNFPVLRDSQ YS--AR-IEENTLNSELLRF---QV
TDWDEEFTDNWWAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
SLQFSIAVRNKAEFHQSV-ISQYRVQSTPVIIQV TNVQEGISFRPPSKTFTVPRDV-S TN
KLAGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAQIKFVKNINRDS
TFIVNKTISAEVLA--IDE---NT-KKTSTGTVFVEVPSFSENCP-SVALEKEEICS---
S-SPSVVVSVRTLERGGYTGPYTMSLEEQPLKLP-VVWNIGMMNA--TSAL--LRAQQQM
SPGVYSVPVIVKDNEGRQCDTPEILTLT--VCQCDDRSMCRAPFPSRGP-----------
------------------------------------------------------------
-----------------------------MI--------YRESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGA-GPIGGGAATGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PVT------------
-------------------------------ANGAGF-MESSEVC--------TNTYTGG
T-V--VEGA---S--GIEMTTKLGAATGSGA------------------AGTLGPCSLGH
S--GTMRTRHS-TGGTLKDYVVA-P-------VN-MTFLGSYFS----------Q---KS
FAYAEEEDEQEVNDCL---LIYDDEG-E----DAGPCSP--ALSSCSFCA-DDLDDSFLD
S-----LGPKFKKLGDICLGIDD-EAKQAKPG---PKDSGSGADICAR----STEVPLAG
PSRYQTLPGSLDIPQSGSQRHQT-------------------------------------
----------------LSGSQDASVVF-TSGS-VHPAIAI-PDPLQL-GDYLLTEAHSA-
SGS-FLQ---PTTATFEPRLTQSVTVTERVMCPLPSVS---GSIVAPT------ELRGSY
SMLYT--------------------------KE-----------AC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLSIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNNLNSKIAYKIISQEPAGTPMFILNRHTGEVCTMSSFLDRE----QHSMYTLVVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIQLSIGVQNVAEFHHSV-ASQFRMHSTPVRIQVVNVREGPTFHPNSMTFSVRQGI-RGD
SLMNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDTNS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-VISAESDTICI---
A-SPSILISV---DEHSYGSPFIFCVDDQPPGTA-NLWDIRSISA--TSAI--LTAAQNL
SHKIYEIPILVKDSYNRECELAQIVTLQ--ACDCDNNHICLYATTTGIYTGHD------S
------------------------------------------------------------
---------------SVTGDIDGL----------VTDDRTGGSNVGLGQTGIGMMVLGLL
----LLL--LSPLLLL--------------------IC-CCKRRQPEG--LGTRFAPVPE
GG-------EGAMRS---W-RVEGARPEDRD------VSNVCVPM--T-----A------
--------------------------------SNTQDRMDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TATGLVAGG------------------------A
A--GAARKRSS-TPGTQREYADT-G-------LN-VAFLDSYFS----------E---KA
YVYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESDME
T-----LDPKFRTLAEICLNTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAV-PEPVVH-GDIVVTETYTTA
--DQCVQ---PTTIVFDPQLAPNVVVTETVMAPIYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVQSS-PGRRDVSNSSMTDG-------
--------CVGPMMSGS---------------------------------ILLGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------TDGMPGNRCHLHC----SGQMHPMICF--T
FG---NGLHLEVLNT-RSESKLLPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEERGVKITYKYTGTGITEPPFGVFVFNKDTGDLNVTSI-LDREETPFFLLT
GYAMDS--RGNNLEKPLELRIKV LDINDNEPVFTEEVF VGSIEELSAAHTLVMKITATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYSLTVEAR
DGDGQITDKPVHQAQVQIR IL-DVNDNIPVVANDA YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KVSHNSSR-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-----------------------------------------------------MICF--N
FG---NGLHLEALNT-RNENNLLPK-HT-----HLMRQKRAWITAPVALREGEDLSKRNP
IAKIHSDIAEERGLKITYKYTGKGITEPPFGVFVFNKDTGELNITSI-LDREETPSFLLV
GYALDE--KGNNLEKPLELRIKVLDVNDNEPVFTQDVFVGSVEELSAADTFVMKISATDA
DEPNTLNSKISYRIVSQEPAYPPVFYLNKDTGEIFTTSFTLDRE----EHSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVKNAMNE--G VEVKENEANVEVTRI---KV
SDADEIGSDNWLANFTFISGNEMGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KELDYEETK
SLDFSIIVTNKAAFHKSV-KNQYKPTSIPIK VKVKNVKEGIHFKSNTISIHVSE--SMDK
S SLSQIIGKFQAFDEDTGQVA-HV-----RYAKLEDIDNWISVDSVTSEIKLVKIPDFES
RYVQNGTYTAKILA--ISE--SYP-RKTITGTIVITVRDINDNCP-TLVDPVQSICE---
D-VQYVNVTAEDLDGHQNSEPFSFSIIDNPAGMA-EKWQIVHQES--TSVL---LQQKEQ
KIGRSEIQFLISDSQGFSCPEKQVLKLT--VCKCLDGSSCVEA-----------------
------------------------------------------------------------
---------------------------------------LRDSYVGLGPAAIALIIFALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPLLLTA-----DHGESVAAGSG
VG-----GGMTTKETIVKG---------SSSASFVKGQHEMCEVD--GRWEEHRNFISAA
VA----QGTTGAN-IGAETLRSTRV----M-----GSSRD---------MA---------
-G----AR-------------------TAAVAVS-EEFLGSYFA----------E---KA
ASYTEEDDIHIAKDCL---LVYSQED-T--------ASLHGSIGCCSFIE-GELDDHFLD
D-----LGLKFRTLAEVCLGQKI-DMDVKIEQR--QKPVGE----------SSM-KAASH
SFDEKTRIHA-------------------ENAYS--SGSSFR-----------------V
PKP--PHE---ANAEKVTQEIVTERSV-SSRQSEKVATLL-PDPLASGNV-VVTETSYAT
-GSTMP----PSTVILGPGQPQALIVTERVYAPAPPLV-------------DQH-CANDG
SVVVT--------------------------ERIIQPNGGIPGPLEGTQPLPDAHYVMVR
ERESFLAPSPGVQPT-LAVPGV-AAGQNVTVTERVR------------------------
-------TAVPTLQSSYQI---PAETSVMARK-----T-----EVSGA--RGPGPLPNF-
--------------------SLEESGHSNS-------------------TVTTSSTRVSK
HSVVQHSYSSTPVDRSLTQSLASSD

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILFMVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYSILSGNDGHWFEIQTDPKTNEGILK-LV-----------------
---------------------------------------------------KMLDYEQEP
NIYLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFSPSSMTFSLRGGM-RGD
SLMNYVLGTYTAIDMDTGNPATNV-----RYVIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGIYAAQILA--IDD---GS-GRTATGTICIEIPDANDYCP-VIYAESRSVCT---
H-ASSVRIYV---SDHSFGSPFTFCVVDESPDTA-NIWDIRSING--TSAI--LMTEQTL
SPGPYQIPIIVKDSHNRACELPQTVLLD--ACFCDDHHVCLHSSTTGIYSGDT------T
------------------------------------------------------------
---------------WVTDDMYGT----------VTDDGVGQSNVRLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TATGMVAGG----T--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAAASEPMIH-GDIIVTETYTTS
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGIPDMGNSNMSDA-------
--------CIGPVMSGG---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PDIHISQT-----TGSTSPMT-SQHRVTR
YSNIHYSRQ----------------

------------------------------------------------------------
-----------------------------------------MARGAEGALLLFLICF--D
F--G-NGLHFEALHS-RNESKLLPK-HI-----HPVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKNLKITYKYTGKGITEPPFGVFVFNKDNGELNVTTI-LDREETPFFLLT
GYALDE--RGKNLEKPIELRIKVLDINDNEPVFTQDVFVGSVEELSAANTLVMKITATDA
DEPNTLNSKISYRIVSQEPASSPVFYLNKDTGEIYTTSITLDRE----EYSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVDRNV YE--GS-VEENQANVEVLRI---KV
SDADEVGSDNWLANFTFASGNEGGYFRIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYETMK
NLDLSIIVTNKAAFHKSI-KDKYKPTSIPIK VKVKNVKEGIYFKSSTIRFHTSE--SMEK
LSQGQILGKFQAFDEDTGKVT-NV-----KYAKFEDIDNWISVNSATSEIKLVKIPDYES
RYVQNGTYTAKILA--ITE--EYP-RKTITGTIVINVEDINDNCP-TLVDPVQTVCD---
Y-VPFVNVTAQDLDGPQNSWPFSFSVIDKPAGMA-ERWKIVRRED--TSVL---LQQTKR
QHGTSEIHFRIADSQGFSCPEEQILKLT--VCNCVEGSGCVNM-----------------
------------------------------------------------------------
---------------------------------------WADSYVGLGPAAIALIILALL
----LLL--LIPLLLL--------------------VCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VVPLLGA-----DVRDGAAVGAA
VGAGVGGGVTAKEAI-VKG---------SSSASFTKGQQEMSEAE--GRWEEYRSLVSGG
ATH--VTGTTGAM-VTSDTFRATRA----T-----GAARE---------VA---------
-G----AR-------------------AGAVAVN-EEFLRSYLT----------E---KA
ASYTEEDDIHTAKDCL---LVYSQEE-T--------ESLRGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGRKI-EMDAETQKR--AKPARE----------ADG-KAVSR
SLYEQTRLNS-------------------ENAYA--SGGSFQ-----------------G
PKP--LHE---ADTEKVTQEIVNERSVISARQAQKVTAPL-PDTLASGSM-IVTETSYAT
----GP----PSTVVLGPQQSQGLIVTERVYAPASTLG-------------NQQ-YASEG
HVVVT--------------------------ERVIQPHGGMSVPLEDTPPLPDAHYVMVQ
ERERFLTPSSSLQPL-LAAPSV-ALGQNVTVTETVL------------------------
-------TPASALQSNYQI---PAETSVMARR-----T-----VASAA--GVPGSLPDS-
--------------------GLEESSHSSY-------------------SVTTSSTRVSK
QSTVQQSS-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFAINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGV-KGS
SLL NYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KHIINGVYTAEILA--IDD---GS-GKTATGTVCIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGSYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMILGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRF------LQSRRWPCFGG-----LPDGSSP
QQQ----IALQAT------------------RALFHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------VAGVAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSDAEFQE-VAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDTSNSSMTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SQHTVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MYQLT
CVAVDE--NDHVLEKPLELRIKVLDKNDNRPNFTESVFVGQVEESSPPGTSVMQISATDA
DEPNTLNSRITYMISRVS-DLQKPFKINNETGEIRTLGSHLDRE----TQSSYTLTVEVT
DLPGNIGSHPPITAQALIKIL-DVNDNFPKAEEEMVT--MITVN----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------FFKEFT---FNL-----TLFKYLQVVV--L
VH--GE-LRIQIKGQ-DGQERTAVQ-QA------KRRYKREWVKFAKPCREREDNSKRNP
IATITSDFQANQ--KITYQISGMGIDQRASFLLVIPLGKS---------FSLHERSFLIT
CRALNA--LGQDVEKPLILTVKILDVNDNPPIFSQSVFMGEIEENSASNSLIMILNATDA
DEPNHLNSKIAFKIVSQEPAGIPMFLLSRHTGEVRTLTNTLDRE----QVGSYHLVVSGA
DQDGVG--L-STQCECRIK VK-DVNDNFPMLRESQ YS--AH-IEENTLSSELLRF---QV
IDWDEEFTDNWLAVYSITSGNEGSWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
TMQLGIAVKNKAEFHQSI-ISQYQIQSTPVTIQVINVKEGITFRPASKTFSVQKGI-SSK
KLVNYILGTYQAIDEDTGKAASYV-----RYAMGRNDGGLLIIDSKTAQIKFNKNIDRDF
TFIVNKTITAEVLA--IDE---NT-GATSTGTIYVEVPDFNENCP-TVDLEKENICS---
S-SPSVVVSAKTLNNDKYTGPYTFSLE-EPFKLP-VVWHITTLNA--TSAL--LRAQQQI
SPGVYRISLLVTDRQDRQCEIPDSLTLE--VCQCDDRDICMPSDPSKDP-----------
------------------------------------------------------------
-----------------------------GP------VYREPSSVELGPAAIGLIILGLL
----MLL--LAPLLLL--------------------ACDCGA-SPLGG--ITSGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------VTNISVP-LIA------------
-------------------------------ANGAEF-LENSEVC--------TNICAGG
T-V--AEGV---S--GMELTTRLGAATGSGNAVGF------------GGATGLGTSSAGQ
S--GTIRTRHS-TVATNKECAEG-A-------IN-MNFLDSYFS----------Q---KA
FACADEENDQEAKDCL---LIYDNE--G----LDAPGSPVGSLSCCSFIA-DELDDTFLD
S-----LGPKFKKLAEITLGVDD-EAKQSQLP---TKESGSGTESSGY----CVEVQQA-
------------------------------------------------------------
---------GSVRSQTLQDSQGASALS-ASGSVLQPAISI-PGPQQH-DNYLVTETYST-
SGT-FVQ---SSTAGFDPLLSQNVIVTEKVVCP--------GNLQGSV------ELRGSR
TVICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RKENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--STD K
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLSV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEENENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASR
SAYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASALV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSLKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MMGLLP---RTP-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
KLV DYILGTYQATDEDTNKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNVDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDGQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------DT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGP
S--GTIRTRHS-TGGTNKDYAEG-A-------IS-MNFLDSYFS----------Q---KA
FACAEENDGQEANDCL---LIYDNE--G----ADATDSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------LLRESH
TMLCS--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLLP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SMKFSIAVKNKAEFHQSV-ISRYRVQSTPVTIE VINVREGIAFRPESKTFAVQKGI-SSN
KLVDYILGTYQAIDEDTRKAASNV-----KYVMGRNNGGYLMIDSKTAEIKFVKNVDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPSFSDNCP-TAVLDKDEICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-VIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSSPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-V--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IHSDVAEERNIKVTYRYAGQGITEPPLGTFVFDKNTGTLNVTKI-LDREEVPVYVLT
AYALDE--KGYNVEKPLELRIRVLDINDNEPVFTQDVFVGSVEELSAAXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXYE--GI-VEENQANVEVMRI---KV
TDLDEVGSDNWLANFTFLSGNEGGYFHAETDSQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEVMK
TLDLKIIVTNKAPFHKSI-RNNFKAKPIPIKVNV KNVMEGIYFKSKKIVI QTSE--QMEK
SELGKIIGSFQAYNEDTGQVA-QV-----TYAKEGDLDHWLTVDSVTSEIRLAKIPDYES
KYVINGTYFAKILA--ITN--DFP-RKTASATIEIVVKDFNDNCP-ELVNPVQTIXX---
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX--TSAW---LIAREL
KVGRSEIHLSVSDNQGLSCPEKQILKLT--VCTCVSGSGCVQP-----------------
------------------------------------------------------------
---------------------------------------LADPYVGLGSGAIGLMIFAFL
----LLL--XXXXXXX--------------------XXXXXXXXX-----XXXXX---XX
-X-------XXXXXX---X-XXXXXXXXXXV------MIPLLTT-----DHGGNFG----
GGNR-TGGQRSSEAT---------------TRESNS-SIILQLVN--REWEELRGLITGG
SKG--TGAAVGAIN-G--------------------------------------ATV--M
TVSGTMSGAT--TVGAAGAMATA-GSRTTTVALS-EEFLRSYFS----------E---KA
ASYAESDEIQTGKDCL---LVYSQEE-T--------QSLQGSIGCCSFIE-ADWDDRYLD
D-----LGIKFKTLAEICIGKKI-EIDSETDPR--HKLPTP----------ASM-NTVSH
SVYEQAEKS----------------------SSSSSSHTSFQ-----------------A
SKP--VSQ---STSETLTQELVSERSL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NM-----CLLIILMVVL--A
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNAPVFTQNV YTASIEENCDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVCTMSSFLDRE----QHSTYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPVLEKTL YS--AS-IKENCLSSELIRL---QA
IDLDEEGTDNWLAKYVILSGNEGNWFDIQTDPQTNEGILK-VI-----------------
---------------------------------------------------KTLDYEKMP
NVQLGIGVKNQAEFHHSV-ASQFRMQSTPVRIQIINVKEGPTFHPSTKTFSVREGI-TGH
SLLTRVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-RKTATGTICIEVPDANDYCP-VVYSETNIICT---
N-SPSVLIYV---RDSSYGAPFTFCVVDEPPHTA-HMWDIRPIND--TSAI--LMTEQIL
LEQLYQVPILVKDSYNRQCELAQIVQLN--ACDCDSNHMCWQWSTTGIYNGGV------S
------------------------------------------------------------
---------------SATDDMNGF----------VTDHGVEDSNVGLGPAGIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPDS--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VAHVHGPM---------------
------------T------------------ASNTHDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TAEVLASGA----A-------------------A
A--GASRKRSS-TMGTLREYADA-G-------LN-AAFLDTYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAT-AEPVVH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVLAS-PGMPDTNSAGMADA-------
--------CVGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-PRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILLMVML--E
VN--GE-FIVEVKEL-DIENGTTT-WQM------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFEIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIYLSIGVKNQAEFHPSV-ASQFQMHSTPVRIQVVNVREGPTFQPSSKTFSLREGI-RGD
SLMNYVLGTYTAIDTDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGMYAAELLA--IDD---GS-GKTATGTICIEVPEANDYCP-VIHAENSIICI---
G-TTSTLIYV---NDRSFGSPFTFCVVDQTLDTA-SKWVISPLNE--TSAL--LMTEDTL
SPGSYQIPVLVKDSHNRACELPQIVLLE--ACYCDTYHICSHSSTTGVYSGDP------S
------------------------------------------------------------
---------------WVITDNYGT----------VTDDGVRQSNVRLGPAGIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGARPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGIG--TAAGLVTGA----A--------------------
A--GALRKRGS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPAHDCL---LIYDHEG-V--------GSSVGSIGCCSWIV-DDVDESHME
T-----FDPKFRTLAEVCLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VSDSSGMT-LSEAEFQAEMAAASEPIIH-GDIIVTETYTTG
--DPCVQ---PTTIVFDPQLAPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVMAS-PGMPDMNNSNMTDA-------
--------CMAPVMSGG---------------------------------ILVGPEIQVT
Q---------VV-----------------S-PDIHISQT-----MGSTSPVA-SRQRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIVLVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFAINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGV-KGS
SLL NYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KHIINGVYTAEILA--IDD---GS-GKTATGTVCIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGSYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVL-----------------
-----RW---MAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRF------LQSRRWPCFGG-----LPDGSSP
QQQ----IALQAT------------------RALFHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAG-----------------------VAGVAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSDAEFQEEVAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDTSNSSMTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SQHTVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------ALLLTSLVVL--E
VN--SE-FQIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTFL GQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAESECSITI L-DVNDNIPYLEQSS YD--IE-IEENALHSQLVQI---RV
IDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAMK
NLQLSIGVRNVAEFHQSI-ISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSR-----
MEANHRVGEFVATDLDTGRAST-----NVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQ
YQRLNGEYKGTVLS--IDD---SL-QRTCTGTIVIELSGTGWVPG---------------
-----------------------------------------SDGG--G------------
-----------------------------------------------------SSSGSGG
NRDPVTNGYQGTSTV-GPQRVTGSGG-----------V--TSSG---GGSGVNN-TPGRQ
NPL-DEPEP------------------------E--PFDITEDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AIEGPQPEPHD-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPDS---SWPPQSTEPMCPQS-T--------E
PL------------------------------------------------GSG---YPPI
SPH----------FG--TTTVISENAY-PSGPGVQHPLPI-PDPLGY-GNVTVRESYATS
-G--TLK---PSVHFHDNQQASNVVVTERVVGPVPGAD-LHGML------EIPDLRDGT-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNPRETSNVVVT
--ERVIQPTSGMIGN-LSMTPELSSAQNVIVTERVVSG-AGMSGIAGTAGLG--------
--------GVGGIGSSGL-----VSTTMGAAG------------------------TG--
---------L-------NMGGTATIGHMRSSSDHHFSQT-----IGSASPNM-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLVVLMVVL--E
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEASQ--KITYRISGPGIDRPPYGVFTINSRTGEINITSV-VDRETTPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNPPVFTQSV YTAAIEENSEANALVVKLSATDA
DEDNHLNSKIAYKILSQEPAGVPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IKENCLSSELLRL---QA
IDLDEEGTDNWLAKYTILSGNDGNWFDIETDSQTNEGILK-VI-----------------
---------------------------------------------------KMLDYEKMP
NVLLSIGVKNQAEFHHSV-ASQFRMHPTPVRIQ VINVREGPMFHPSSKTFSVREGL-TGQ
SS SSRVLGTYTAIDLDTGSPATNV-----RYIIGHDAGNWLKVDSRTGEIQFSREFDKKS
KYFTNGIYKAQILA--IDD---GS-EKTATGTICIEVVDAKDYCP-VIYSERNIVCT---
N-SPSVLIYV---SDSSYGSPFTFCVVDQSPETT-PVWDIRSING--TAAI--LMTEQTL
SEQLYQVPVVVKDSYNRQCELPQIVQLN--ACDCDSNHMCWQWSTTGVYNGGV------S
------------------------------------------------------------
---------------SVTDDMNGF----------VTDPGVTDSNSGLGSTGIGMIVMGLL
----LLL--LSPLLLL--------------------LC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGARPEDRD------VSHICGPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTATAMVTAEGLATGG----A-------------------A
A--GASRKRSS-TMGTLREFADP-G-------LN-VAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LVYDHEG-V--------GSPVGSIGCCSWIV-DDLDESHME
P-----LDPKFRTLAEICLDTEI-EPFPS-HQ---SCIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGTT-LSEAEFQAEMAK-TEPVVH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVLAS-PGMPDMNSVGMADA-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
R---------MV-----------------S-PDIHISQT-----IGSTSPMT-PRHRVTR
YSNIHYSPQ----------------

------------------------------------------------------------
----------------------------------------PT-----GALVIFMV-----
---------SPTKGQ-YDEEGMVVQ-QA------KTRHKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDLKHNKL-IDQR----NQIT
CRALNA--QGLDVERPLILTVKILDINDNPPVFSQSIFVGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QTSSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPILKESQ YS--AR-IEENTLSSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISQYRVQSTPVTIQVINVREGVAFRPASKTFTVQKGI-SSK
KLVDYILGTYQAIDEDTGKAASNV-----KYVMGRNDGGYLMIDSKTAQIKFVRNMDRDS
TFIVNKTITAEVLA--IDE---YT-GTTSTGTVYVTVPGFSDNCP-TAVLEKDELCS---
S-SPSVVVSARIPN-NRYTGPYTFSLEDQPVKLP-AVWSITTLNG--TSAL--LKAQEQI
APGVYHISLVLTDSQNNRCDMPDSLTLE--VCQCDNRGTCGTFNPTVDP-----------
------------------------------------------------------------
-----------------------------GT------RGRRSFPGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-V--AEGA---S--GMEMTTKLGAANGSGSAAGFAAGTVSGAAAGFGAATGLVICSSGQ
S--GTMRTRHS-TGGTNKEYAEG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGIDN-EGKQVQPP---SKDRGYGTESCGH----SKEVQQL-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQP-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRGSR
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MTCPFP---RVL-----GPLALLMVM----
----RS-LSTQPGGQ-HREDGTAVQQ-V------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDPNSGDINITAI-VDREETPSFLIT
CRALNA--RGQDVERPLILTVKI LDVNDNAPIFSQTIF KGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGMPMFLISRNTGEVRTLTSSLDRE----QVSSYHLVVSGA
DNDGRG--L-STQCECSIK VK-DVNDNFPLLTDSQ YS--AR-IEENTLNSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
STQFSIAVRNKAEFHQSV-ISQYRVQSTPVIIQ VINVREGISFRPPSKTFIVPKGV-ST N
KLAGYILGTYQATDEDTGKAASSV-----RYVLGRNDGGLLVIDSKTAQIKFVKNIDRDS
TFIVNKTISAEVLA--IDE---NT-GKTSTGTVHVEVPSFSENCP-SVVLEKEEICS---
S-SPSVVVSVRTLERDKYTGPYTVSLEEQPLKLP-VMWNIGMMNA--TSAL--LRAQQQM
SPGVYSVPVTVKDNEGRQCDTPEILTLT--VCQCDDRSMCRAPTPSRGP-----------
------------------------------------------------------------
-----------------------------II--------YRESSWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGA-GPIGGGAETGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TNGADF-MESSEVC--------TNTYAGG
T-V--VEGA---S--GMEMTTKLGAATGSAA------------------TGALGPCSLAH
S--GTMRTRHS-TGGTLKDYVAA-P-------VN-MTFLGSYFS----------Q---KS
FAYAEEEGEREVNDCL---LIYDDEG-E----DAAPCSP--ALSSCSFIA-DDLDDSFLD
S-----LGPKFKKLGEICLGIDD-EAKQAKPG---PKGSGSGADICAR----PTEVPQSG
SQRYQTLSGGLEVPQSGSQRHQT-------------------------------------
----------------LSGGQDASVVF-TSGS-VHPAIAI-PDPLQL-GNYLLTETHST-
SGS-FVQ---PTTATFEPHLTQNVTVTERVICPLPSVS---GSIVAPT------ELRGSY
NMLYT--------------------------KE-----------TC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHIFR--TA------AVLFIFLVVV--E
VN--CE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYEISGVGIDRPPLGIFVVNRKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMST FVGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGIDGM-SAECECNIRI L-DVNDNIPYFDQSS YS--IS-IDENALYSGLTEI---RV
IDLDEEYSANWIAVIFFLSGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEEMK
SLQLSIGVRNKAEFHQSI-ISQYKITATIISVTV LNVIEGPVFRPGS KTFVVNSN-----
MGQNYEVGKFVATDLDTKQVSTT---V--RYVMGNNPADLLVVDSRTGILTLKNKVTRRQ
YDMLNGKYQGTILS--IDD---NL-QRTCTGTIVIDLDGSGWEEE---------------
-----------------------------------------RDTN--T------------
-----------------------------------------------------NTNGGN-
---------------VDNGSD---G-----------------------STT---------
-----------------------------SGGSEIDTNTNNGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLM--------------------CCECGGA---PG--GGAGFEPVPE
CS-------EGAIQP---W-ALEGPQPEMTD-----LT-TICVPQMP----PD-------
------------N-------------------ANLIECIDNSGVY--------TNEYCGR
EMQ-DLGGGDRTT--GFELSEGVKTSAAP------------------------DICQ-DY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDFDDSFLD
T-----LGPKFKKLADISLGKEV-EDYPYPDS---TWPPDNTEPMCPQQGL--------E
PM------------------------------------------------YNG---HPPM
SPH----------IG--TTTVISE-SY-PSGPGVQHPMQI-PDPLSY-GNVTVTESYTTS
-G--TMK---PSVHIHDNRHGSNVVVTERVVGPISGAD-FHGML------DMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PDPRDSSNVVVT
--ERVIRPTSGMMGN-LSMHPDLSNAHNVIVTERVVSG-AAMTGISGQGGIS--------
--------GGSGTVSSGM-----MSTNMGVS-----------SGLSGV--GMSSGGIGLS
-----------------SMGGTATIGHMRSSSDHHFSQT-----VGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIKVKVKNVKEGIHFKSSVISTYVSE--SMDR
SSKDQIIGKFQTFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDEPPGMA-AKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAITLMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--VTGATGAI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAADALN-EEFLRNYFS----------D---KA
ASYTEEDENYTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATV----------TSM-NTASH
SPYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTMP----PSTVILGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGLNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVLGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------VSFDLFE---NT-----LLNISKMLV-INL
LN--WI-FFLKVKEL-DSENGTAK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEANQ--KITYRISGIGIDRPPFGVFTINPRTGEINITSV-VDREITPMFLIY
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTASIEEHCATNTLVIKLSATDA
DEENHLNSKIAYKIISQEPAGSPLFILNRYNGEIRTMTNYLDRE----EHSTYNLVVRGS
DRDGAADGL-SSECDCRIK II-DVNDNFPTLEQTS YS--AS-IEENCLSSELIRF---QA
IDHDEENTDNWLADFFFVSGNDGNWFEVHTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NMQLSIGVKNKAEFHHSV-ASHYRIQATPIRIQVINVREGPIFNPNSMTFRVQEGL-RGD
ALLNYVLGRYTATDLDTGIAATNV-----RYIMGHDAASWLKVDSRTGEIQFSREFDPKS
KHVINGIYTAEILA--VED---GI-GKTATGTICVEVPDDNDFCP-RIFSDSRHICV---
A-SPSVIISTK---DDSFGSPFTYCVMDQPPGTA-DLWDIRSINA--TSAI--LTAVQEL
SLGLYQIPILVKDTFDRTCELPQNIKLE--ACECDDNHMCSYYSTTGIYPGSP----SIT
------------------------------------------------------------
---------------IITDDNYGT----------MAGDR--DGNVGLGPAGIGLIVLGLL
----LLL--LMPLLLL--------------------IC-CCKRKAPAG--LGTRFAPVPE
GG-------EGVMQS---W-GIEGAHPEDRD------VSNICVPITA-------------
--------S------------------------NTQDRLESSEIY--------TNTYAGG
GTV--EGGASGVS--GVELNTGVG--AALSLGAGG------------------------L
S--GAVRRRGS-AIGTLREYAET-G-------VN-MAFLDSYFS----------E---KA
YAYADEDECRPANDCL---LIYDHEG-M--------GSPVGSIGCCSWIV-DDLDDSYLE
T-----LGPKFRTLAEICLDTEI-EPFPSPHQ---AWIPITT------------DLPLLG
TNY---------------------------------------------------------
-----------------I-VNESSAMS-LTEAGFQAEMAM-PDPMIH-GDIIMTESYSTS
--DQCVQ---PTTIIFEPQLVPNVLVTETVMAPAYAMQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYTERIVPS-PGMTAMSNSSMTSG-------
--------CLGTGMSGS---------------------------------GMVGPDIQVT
Q--------------------------I-VNPDVHVCQT-----M--GSPMT-SRRRVTQ
HSTVQYFQP----------------

------------------------------------------------------------
------------------------------MARSPGRLCA---------LLLLLICF--N
FG---NGLHFEALNT-RNENKLLTK-HT-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERGIKVTYRYTGKGITEPPFGVFVFNKDTGELNVTSI-LDREETPFFLLV
GYALDE--KGKNLEKPIELRIRVLDINDNEPVFTQDVFAGSVEELSAAHTLVMKINATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYSLTVEAR
DGNGQVTDKPAKQAQVQIRIL-DVNDNIPVVESKMLE--GL-VEENQVNVEVMRI---KV
FDADEVGSDNWLANFTFASGNEGGYFHIETDAQTNEGILT-LI-----------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------KYAKLEDMDNWVSVDSATSEIKLAKIPDFES
RYVQNGTYTVKIMA--ISE--DYP-RKTITGTVRIMVEDVNDNCP-TLVDPVQTICH---
D-VPHVNVTAEDLDGYPNSGPFSFSVIDQPPGMA-EKWKIVRQES--TSVL---LQQSEQ
KLGRHEIQFLIADNQGFSCPEKQILTLT--VCDCLDGSGCAEA-----------------
------------------------------------------------------------
---------------------------------------FHSSSVGLGPAAIALMILALL
----LLL--LIPFLLL--------------------TCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VLPLLAV-----DQGDSLAVRNG
VG-----GIT-REAI-VKG---------SSSASFTKGQQEMSEME--GRWEEQRSLLTSG
AAQ--VTGAAGAV-TGAESVRTTRA----A------------------------------
--------------GASRDMV---GARVAAGAVN-EEFLRSYFT----------D---KA
ASYTENDEIHTAKDCL---LVYSQEE-T--------ESLHGSLGCCSFIE-GEQDDRFLD
D-----LGLKFKTLAEVCIGQKI-DTDMQIEQR--QKPVTE----------TST-KAASH
TLYEQTKVDS-------------------ENTYA--SGSSFQ-----------------V
PKS--LQE---ANAEKVTQEIVTERSM-SSRQAQKVAAPL-PDPLASSNI-IVTETSYAR
-GSTMP----PSTVILGPTQPQSLIVTERVYAPAATLV-------------DQH-YANEG
KVMVT--------------------------ERIIQPNGGVSDPLEGTPPLQDAQYIMVK
ERESFLAPSSGVQPT-LAMPNV-AVGQNVTVTERVI------------------------
-------APASTLQSSYQI---PAEDSVKARK-----T-----LVPGA--GVLGALPTF-
--------------------GLEESGHSNS-------------------TMTTSSTRVTK
HSMVQHSYS----------------

------------------------------------------------------------
------------------------------MHWLSS---RTT-----GALAVLMVVV--L
VH--GE-LRIQXXXX-XXXXXXXXX-XX------XXXXKREWV-FARPCREREDNQKRNP
-AEITSDFQKTQ--KVTYQISGVGIDQPPFGIFVVDKYTGKINITAI-VDREETPSFLIT
CRALDY--LGQDIEKPLILTVKILDVNDNAPVFSQSIFMGEIEENSASSSFC--------
------------------------------------------PT----QMSSYYLLVSGA
DQDGEG--L-STQCECKVKVK-DVNDNFPVLKESQXX--XX-XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXRYFFFTSKNGGNWFAIQTDPRTNDGILQ-VV-----------------
---------------------------------------------------KALDYEQMQ
KVQLGIAVKNKAEFHQSI-ISQYRALSTPVTIQV VNVREGLIF-PSSKT FPVQKGI-SSK
KLINYVLGTYQAIDEDTGKAATSV-----KYLMGRNNGGWLTIDSKTAEIKFIKNIDRDS
TFIVNKTITAEILA--VDE---NT-GKTSTGTVF-GVPDLNENCP-TVVSXXXXXXX---
XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX--TSAM--LSAQQQI
SPGVYRVFLAVKDGQNRLCEIPESVTVE--VCQCDHRDVCGTYDPGKDS-----------
------------------------------------------------------------
-----------------------------GI------TGREWSSVKLGPAAIGLIFFGLV
----LLL--LAPLLLL--------------------TCNGGM-GPIGG--VAGGFVSVPD
GS-------EGTIQQ---W-KIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------VNGFEF-MENSEDR--------TXXXXXX
X-X--XXXX---X--XXXXXXXXXAATGSG-AAGFVTGTVCGA--------AVGTCSAGH
S--GTIRTRHS-TGATTREHAEG-A-------IS-MSFLDSYFS----------Q---KA
FACAEVDDDQEANDCL---LIYDSE--G----MDPPGSPVGSVGRCSIIT-ADLADSFLD
I-----GLPKFKK-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MAWLPF---RTT-----GALAILTVVL--L
VH--GE-LRIQTKGQ-YEEYETAIQ-QG------KRRYKREWVKFARPCREGEDNSNRNP
IAKITSDFEATQ--KITYHISGIGIDQPPFGIFVIDKNTGEINITAI-VDREVTPSFQIT
CRALNT--LGQEVEKPLILTVKI LDINDNAPVFSQSIF QGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTPMFLLSRHTGEVRTLTSSLDRE----QVSSYRLVVSGA
DRDGEG--L-STQCECSIK VK-DVNDNFPTLRESQ YL--AR-IKENTLSSELLRF---QV
IDLDEEFTDNWLAEFFFTSGNEGNWFEIQTDPQTNEGILQ-VV-----------------
---------------------------------------------------KSLDYEQVQ
SMQLGIAVKNKAEFHQSV-ISQYQVQSTPLIVE VINVREGITFRPSSKTFIVRKGV-SS R
QLINYVLGTYQAIDEDTGEVASFV-----RYVLGRNDGGLLTIDSKTAEIKFVKNIDRDV
TFIVNKTITAEVLA--IDE---NT-GKTSTGTIIVYVPDFNENCP-TIALEKEVVCS---
S-SPSVVVRASPLQRDKYAGPYEFSVEGQSVKLP-VAWSISGTDA--TSAL--LTAPQPV
SPGVYRISVVVTDSEGRRCETPESLTLE--VCQCDYRDICRNAPPTSSP-----------
------------------------------------------------------------
-----------------------------HT------I--R-EGSRMGAAAIGLLFLGLL
----LLL--LALLLLL--------------------TCDCGA-GPIGG--VTGGFVPVPD
GS-------EGTIHP---W-GIEGAQPEDKE------ITNISVP-PIT------------
-------------------------------ANGVDF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTRLGAAAGSGGAAGFGA------------TAGLSNFSMGQ
S--GTMRTRHS-TGGTNKDFGEG-A-------IN-MKFLDSYFS----------Q---KA
FACADEDDGQEANDCL---LIYDNE--G----IEAPSSPVGSLGCCSFIA-DDFDESFLD
S-----LGPKFKKLAEISLGMDE-ETKNSQSP---TKDSSSRVDAYDQ----HVQVQQS-
------------------------------------------------------------
---------ESVRHQTLSGSQGASALS-ASSSVLQPAISI-ADPLQH-GSYLVTETYSAS
SGS-LVQ---PPAAVFDPLLTQNVIVTERVICPIPSIT---SNLHGPT------ELRGSG
SKIFT--------------------------ED-----------PS--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------V-KE-WDENGMAR-WKT------FRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEEDN--PITYSISGVGIDRAPYGIFVVNPRTGEINITSV-VDREITPVFVIR
CFAKHS-VTGIDLEPPLELRVRVLDINDNPPVFAQTVFTGSVEESSMDNTLVMKIIATDA
DEPNHLNSKIAFKIESQEPSGPPMFIMNKYTGELH-LANYLDRE----QHSSYTLVVKAS
DRDGAADGI-SSLCSCNVK VI-DVNDNFPTLAQSSFS--TS-ISENSLSSELLRI---QA
LDADEEFTDNWLAEFFFISGNEDNCFEIVTDRATNQGILR-VI-----------------
---------------------------------------------------KELDFEHMR
THSLMIGVR NVAAFHHSV-AHEYQIFGTPLTVEVKNLIEPPRFHPSSI VFSLAEG-----
ARVNYVLGTYTAMDEDTRTIASNV-----VYSIGRDPAAWFRINQNTGEITLNKVINRDS
VYIVNGQYQAEVLA-ITRG---TP-RYTATGTVVLSIDGINANCP-TINTEMRKVCM---
N-SPSVIISAKHRNGDLYATPFTFSIHG-EPQ---TTWIIRRIND--SSAE--LV-GQNI
DFYLYRIYVVVRDSQGRRCAQPHIIPVQ--ACQCDSRNYCTSGATRIIIIGGGGGSGGGT
GGGTGGGTGGGT------IGGGG-GG-----TD---------------------------
-------------------------------------------------------RLIGY
----LVR--NIL-----KA----------YFQDDCC--GCGP-GAAGG--VGTGFEPVPE
CT-------EGAIHP---W-GIEGAQPEDRD------VSHILAPTTAA------------
-------------------------------GGDFGEPS---DIY--------NNTYGGG
G-V--VA-----S--GVE----E------TTGVGYGTGTGYGTAG-------------GI
S--GTGEAKGSI-GGTIKEYREG-G-------VN-MAFLDNYFS----------E---KA
FVYADEDEGRPANDCL---LIYDHEG-V--------GTPVGSVGCCSFIG-EDTDETYLD
T-----LGPKFKTLAEICLGKEI-EPFP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWCF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YR--VD-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAITVTVLNVIEGAVFRPGSKTYVVTGN-----
MGSNYKVGDFVATDLDTGGPSTT---VR--YVMGNNPADLLAVDSRTGIITLKNKVTREQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTINIDIQNVDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQASTEV
---------------TNTVREES----------T-------------SSTNYETSTTYAI
SQ------------------P-----VTSTV-HNNEETPLFADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-IIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELTNAHNVFVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
-----------------------------------------MARGAGGALLLLLICF--N
FG---NGLHLEALHS-RSENEQLPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGLKITYKYTGKGITEPPFGVFVYNKDTGELNITSI-LDREEIPFFLLI
GYALDE--KGSNLEKPIELRVKV LDINDNEPVFTQDV FVGSVEELSAANTLVMKINATDA
DEPNTLNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYTLTVEAR
DGNGQITDKPVKQAQVQIRI L-DVNDNIPVVENKV YE--GT-VEENQANVEVIRI---KV
SDADEVGSDNWLANFTFASGNEGGYFRIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
SLNFSIIVTNKAAFHKSV-KNKYKPTAIPIRVKV TNVKEGVYFKSSTIRF HTSE--SKEI
SSQNPIMGKFQAFDEDTGQLA-RV-----KYAKFEDIDNWISVDSATSEIRLVKIPDYES
RYVQNGTYTVKIVA--ITE--EYP-RKTITGTIAIMVEDINDNCP-TLIDPVRSVCD---
D-AQYVNVTAEDLDGPQNSWPFSFSVIDKPAGMA-EKWRIVRQES--TSAL---LQQNEQ
KLGXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX--XXXX---------------
------------------------------------------------------------
---------------------------------------XXXXXXXXXXXXXXXXXXXXX
----XXX--XVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPPLLTA-----DXXXXXXXXXX
XX-----XXXXXXXX-XXXXXXXXX-------XXXXXXXX--XXX--XXXXXXXXXXX-X
X-X--XXXXXXXX-X--XX--XXXX----X-----XX-X----------XX---------
-X----X---------XXXXX---XXXXXXXXXX-XXXXXXXXX----------X---KA
ASYTGEDDIQTAKDCL---LVYSQEE-T--------ESLQGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-EMEPEIELR--PKPRRE----------TNA-KAASS
AFYEQTRVHS-------------------EKALS--SSGSFQ-----------------V
PTP--LHE---ASTEKVTQEVVTEKSV-SSRQGPKVATP--PEALASGSM-IVTETSYAT
-GSTVP----PSTVVLGPGQSQGLIVTERVYAPASALV-------------EQQ-YASEG
NVLVT--------------------------ETVLQPHGGVSGPLEGTQHLPDAHYVMVR
ERERVLAPSPSVQPA-LAVPSA-AAGPSVPVTERVL------------------------
-------TPASALQSSYHI---PAETSVTATK-----T-----LVSGA--GVPGP-PDL-
--------------------GLEESGHSNR-------------------AITTSSTHISR
QSTVQLSYS----------------

------------------------------------------------------------
------------------------------MAWLFP---RTT-----GALAILMVVV--L
VH--GE-LRIEIKGQ-HEEDGAATQ-QA------RRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDQNTGDINITAI-VDREETPSFLIT
CRALNV--LGQDVEKPLMLTVKI LDVNDNSPVFSQRTF EGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGAPMFLISRNTGEVRTLTNSLDRE----QISSYRLVVTGA
DKDGDG--L-STQCECTIK VK-DVNDNFPTLRDSQ YS--AS-IQENTLSSELIRF---HV
TDWDEEFTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQIQ
NMQFSIGVRNKAEFHQSV-ISQYRVQQVPVTVHVINVKEGIAFRPTSKTFTVQKGI-SNK
KLVNYVLGTYEAIDEDTCKAATSV-----RYAMGRNDGGLLVVDSKTAQIRFVKNIDRDS
TFIVNKTITAEVLA--IDE---NT-GKTCTGTIFVEVPGFNENCP-AVVLEKERVCS---
S-SPSVIVSAGTLDRDKYAGPYTFSLEDQPVKLP-VMWRITTLNA--TSAQ--LRAQQQV
SPGVYRLPLVLTDREDRQCETPESLTLE--VCQCDDRGICGTSGPVRDP-----------
------------------------------------------------------------
-----------------------------TI-------YRNPASWRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGT-SPIGG--GTGGFIPVPD
GS-------EGTIHP---W-GIEGAHPEDKE------ITNIRVP-PIA------------
-------------------------------GNGAEF-MESSEVC--------TNMYAGG
T-V--VEGA---S--GMELTTRLGAAAGSGATAGFGAA------AGLG--------STGQ
S--GTMRTRHS-TGGTSKDYADG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEEDVHDGNDCL---LIYDNEE-D----MAVPSSPVGSLGCCSFIA-DDLDDSFLD
S-----LGPKFKRLAEISLGMDE-EAQRARLS---SQDSGARSESRGP----APDTQQA-
------------------------------------------------------------
---------GTMRGQTLSGSQGVFTLS-ASGS-MQPAISI-PDPLQH-ANYLVTETYSA-
SSS-LVQ---PSSVVSDPLLTQSVTVTERVVCPRAAVS---GSLIVPT------ELRGSR
SILCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCELNQ--KITYRISGVGIDRPPYGIFTINPRTGEINITSV-VDREITPLFLIY
CQAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENCDANALVVKLSATDA
DEENHLNSKIAYKIVSQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSTYHLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTL YS--AS-IEENCLSPELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPETNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
TIQLGIGVKNQADFHYSV-ASQFRMHSTPVRIQVINVREGPTFHPSSMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPAKNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-DIIPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQFL
SPGSYQIPILVKDSYNRACESAQIVQLH--ACDCDDNHMCLDSGTAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGVL
----LLL---LAPLLL--------------------LLCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAPMTAS------------
---------------------------------NTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGLG--TAAGLVAG------------------------GA
T--GATRKRSF-TVGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VSESSGLT-PSEAEFQEEMAA-SEPVIH-GDIIVTETYGAA
--DQCVQ---PTTIIFDPQLVPNVVVTETLMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CMGPVMSGS---------------------------------VLVGPEIQVM
Q---------MM-----------------S-PDIPISQT-----VGSASPMT-PRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
--------------------------------------MALGAGGSLL---LLLICF--N
FG---DGLHLEALHS-RNENKLLPK-HT-----HSVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDVAEEKDLKITYKYTGKGITEPPFGVFVFNKDTGLLNVTTI-LDREETPFFLLM
GYALDE--KGNNLEKPIELRIKV LDINDNEPVFTQDV FVGSVEELSAANTLVIKITATDA
DEPNTLNSKISYRIVSQEPASSPLFYLNKDTGEVYTTTIALDRE----EHSSYTLTVEAR
DGNGQVTDKPVKQAQVQIHI L-DVNDNIPVVENKV YE--GI-VEENKANVEVLRI---KV
FDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDVNIIVTNKAAFHKSV-KNKYKPTPIPIKVKV KNVKEGIYFKSSIIQFH TSE--SVEK
SSQSQIMGKFQAFDGDTGQVA-RV-----KYAKFEDIDNWISVDSATSEIRLVKIPDYES
RYVQNGTYTAKILA--VTE--EHP-RKTITGTISITVEDINDNCP-TLVDPVQTVCD---
D-VQYVNVTAEDLDGPQNSWPFSFSVIDKPAGMA-ERWKIVSRES--TSML---LQQKER
TLGRSDIHLLIADSKGFSCPEKQVLKLT--VCKCVEGGGCVEM-----------------
------------------------------------------------------------
---------------------------------------WIDSYVGLGPAAIALIMFALL
----LLL--LVPLLLL--------------------KCRCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKA------VLPLLEA-----DHRDCAAVGGG
-----AGAVTTKGAT-VKG---------SSSASFIKGQHEMSEVD--GRWEEYRSFVSGG
ATQ--VTGTAGAL-MTTETLRTTRA----T-----VASRE---------VA---------
-G----AR-------------------AAAVAVN-EEFLRSYFT----------E---KA
ASYAEEDDIHTAKDCL---LVYSQEE-T--------DSLQGSIGCCSFIE-GELDDGFLD
D-----LGWKFKTLAEVCWGQKI-EMDMEIEQR--PKPMRE----------TDV-KAASH
SFYEQTRVNS-------------------EYTYP--SGSSFQ-----------------V
PKP--LHE---ANTEKVTQEIVSEKSV-SSRQAQKVAAPL-SDPLASGNV-IVTETSYTT
-GSTVP----LSTVVLDPRQSEGLMVTERVYAPASLLG-------------EQQ-YASEG
GIMVT--------------------------ERVIQPHGGSPGPLEGTLHLPDAHYVMVR
ERERFLTPSSRVQPP-LAAHSV-AVGQNVTVMERVL------------------------
-------TPASTLQSNYQI---PSETSVMAKK-----T-----VVSGA--GVPGPPPDS-
--------------------GFKESSHSNY-------------------TITTSSTRVSK
PSTVQQFS-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANTLVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFQMHPTPVRIQ VVDVREGPAFHPSTMAFSVREGI-KGS
SLLN YVLGTYTAIDLDTGNPATDV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDEPPGIA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLI---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAYALPGGGG--TADG-GG-SV
LGR----CALQAT------------------PALLNQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAVGLMAAG----AA-----------------GA
S--GAARKRSS-TMGTLRDYADA-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DPCVQ---PTTIIFDPQLAPNVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTEG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPIGQT-----VGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
---------------------------------HSVK--IN------YCYCFLQVVL--E
VN--SE-FHIQVRDH-NAKNGTIS-WHT------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLESPLELRVR VMDINDNPPVFSMTTF TGQIEENSNANTLVMKLDATDA
DEPNNLNSKIAFKIIRQEPSESPMFIINRGTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAECECNIRI L-DVNDNIPYLEQSS YA--VS-IEENAMHSQLAQI---RV
IDLDEEFSDNWKALLFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMK
NMQLSIGVRNVAEFHQSI-ISQYRITATMITVTVLNVIEGSVFRPGSKTFVVNSQ-----
MGANYKVGDFTATDLDTGLVS-----TNVRYVMGNNPADLLAVDSRTGIITLRNRVTMEQ
YETLNKRYEGTILS--IDD---NL-QRTCTGTVIIDLDGSGWVTG---------------
-----------------------------------------DGGS--T------------
-----------------------------------------------------EGGGGST
GGGDSTGGGDTSENTSTEEMQVTTGS-----------W--ENGDN------GDNNGRGPY
----------------------------DNGDGTGIDRQPGGDNVHLGPAGIGLLVMGFL
----ILG--LVPFLLL--------------------CCDCGGA---SG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQML----PG-------
------------N-------------------GNIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
T--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPEP---SWPPQSTEPVCLQQ-T--------E
A----------------------------------------------------------I
SPH----------FG--TTTVISENTY-PSGPSVQHPMQI-PDPLGY-GNVTVMESYTSS
-G--TLK---PSVHFHDNRQASNVVVTERVVGPISGAD-LHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-ANPRESSNVVVT
--ERVIQPTSSMMGN-LSVPPELSNAHNVIVTERVVSG-AGVSGMSGTTGIG--------
--------GVGGVGGGSL-----VSTTMGA-G----------GT-------------L--
---------S-------SMGGTATIGHMKSSSDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MARSPGDRCALLL----LVQLLAVVCL--D
FG---NGLHLEVFSP-RNEGKPFPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSI-LDREETPYFLLT
GYALDS--RGHNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDA
DDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDRE----EHSSYSLTVEAR
DGNGQITDKPVQQAQVQIR IL-DVNDNIPVVENKM YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYEEMK
KLDLSILVTNKAAFHKSI-LSKYKATPIPITV KVKNVVEGIHFKSSVVSFRASE--AMDR
S SLSRSIGNFQVFDEDTGQAA-KV-----TYVKVQDTDNWVSVDSVTSEIKLVKIPDFES
RYVQNGTYTAKVVA--ISK--DHP-QKTITGTIVITVEDVNDNCP-VLVDSVRSVCE---
D-EPYVNVTAEDLDGAQNSGPFSFSIIDQPPGTA-QKWKITHQES--TSVL---LQQSER
KRGRSEIPFLISDSQGFSCPERQVLQLT--VCECLKGGGCVAA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGGGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVA-----DHAESSAVRGG
VG-----GAMLKEGM--------MKG--SSSASVTKGQHELSEVD--GRWEEHRSLLTAG
ATH--HVRTAGTIAANEAV--RTRA----T-----GSSRD---------MS---------
-G----ARG--------------------AVAVN-EDFLRSYFT----------E---KA
ASYNGEDDLHMAKDCL---LVYSQED-T--------ASLRGSVGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGRKI-DVDVDIEQR--QKPVRE----------ASV-SAASG
SHYEQAVTSS-------------------ESAYS--SNTGFP-----------------A
PKP--LHE---MHTEKVTQEIVTESSV-SSRQSQKVVPP--PDPVASGNI-IVTETSYAK
-GSAVP----PSTVLLAPRQPQSLIVTERVYAPTSTLV-------------DQH-YANEE
KVLVT--------------------------ERVIQPNGGIPKPLEVTQHLKDAQYVMVR
ERESILAPSSGVQPT-LAMPSVAAGGQNVTVTERIL------------------------
-------TPASTLQSSYQI---PSETSITARN-----T-----VLSSV--GSIGPLPNL-
--------------------DLEESDRPNS-------------------TITTSSTRVTK
HSTMQHSYS----------------

------------------------------------------------------------
------------------------------MDWLFLR---NI-----CLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGSPMFIMNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGI-KGS
SLL NYVLGTYTAIDLDTGNPATDV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDEPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAPMTAS--N---------
----------------------------------TQDRMDSSEIY--------TNTYAAG
GTA--EGGV---S--GVELNTAMG--TAVGLMAAG----AT-----------------GA
A--GAARKRSS-TMGTLRDYADS-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DQCVQ---PTTIIFDPQLAPNVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSTTDG-------
--------CKGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----IGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILLVVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYSILSGNDGNWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEEVP
NIYLSIGVRNKAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFRPSSMTFSLREGV-RGD
SLMNYVLGTYTAIDTDTGNPATNV-----RYTIGHDAGSWLKVDSRTGEIQFSREFDTKS
KYITDGIYAAEILA--IDD---GS-RRTATGTICIEVPDANDYCP-IIYSERRSVCV---
D-ASSVRIYV---SDHSFGSPFTFCVVDESSDTA-SIWNIRSINE--TSAI--LMTEQTL
SPGLHQIPILVTDSHNRACELPQTVLLD--ACFCDDHQVCLHSSTTGIYSGDT------I
------------------------------------------------------------
---------------WVTDDTYG------------TDDGVGQSNVRLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTAVG--TTAGLVAGG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMEAASEPMIH-GDIIVTETYTTA
--DPCVQ---PTTIVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVYYAERVVAS-PGVPDMGNSNMTDA-------
--------CMGPMMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSNSPMT-SQHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NV-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLESPLELRVK VMDINDNPPVFTQNV YTASIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSSFLDRE----QHSMYSLLVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPVLEKTS YS--AS-IKENCLSSELIRL---QA
IDLDEEGTDNWLAKYIILSGNEGNWFDIQTDPQTNEGILQ-VM-----------------
---------------------------------------------------KTLDYEKMP
NVLLSIGVKNQAEFHHSV-ASQFRMQSTPVRIQIVNVREGPMFHPTSKTFSVREGI-AGH
SLLTHVLGTYTAIDLDTGSPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDVNDYCP-VVYSERNIICT---
N-SPSVLIYV---SDSSYGSPFTFCVVDQPPETT-PTWDIRSING--TAAV--LMTEQML
SEQLYQVPILVKDSYNRQCELPQIVQLN--ACDCDSNHMCWQWSTTGIYNGDV------G
------------------------------------------------------------
---------------SVTDDMNGF----------VTGSGVGDSNGGLGSAGIAMIVLGLL
----LLL--LSPLLLL--------------------LC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSHICGPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTAVG--AAECLATGA----A-------------------A
V--GASRKRSS-TMGTLREYADA-G-------PN-VAFLDSYFS----------E---KA
YAFADEDEGRPANDCL---LLYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAA-TEPVIH-GDIIVTETYTTA
--EPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVLAS-PGMPDANSVGMADA-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------N-PDIHISQT-----IGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------VMGLFP---RPS-----GALVILVVVM--L
VH--GE-LRIETKGQ-YDEEGMVLQ-QV------KTRHKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVERPLILTVK ILDINDNPPVFSQSIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QTSSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPILKESQ YS--AS-IEENSLSSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGI-SSK
RLVDYILGTYQAIDEDTGKAASNV-----KYVMGRNDGGYLMIDSKTAQIKFVRNMDRDS
TFIVNKTITAEILA--IDE---YT-GKTSTGTVYVKVPGFSDNCP-TAVLEKDELCS---
S-SPSVVVSARIPN-NRYTGPYTFSLEDQPVKLP-AIWSITTLNG--TSAL--LKAQEQI
APGVYHISLVLTDSQNNRCDMPDSLTLE--VCQCDNRGTCGTFSPTTDP-----------
------------------------------------------------------------
-----------------------------GI------RGRRSFPGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-SVT------------
-------------------------------ANGVDF-IESSEVC--------TNTYARG
T-V--AEGA---S--GMEMTTKLGAANGSGSAAGFAAGTVSGAAAGFGPATGLGICSSGQ
S--GTMRTRHS-TGGTNKEYADG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEDNGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDD-EGKQVQPP---SKDRGYGTESCGH----SKEVPQP-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVTI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTSGFDPLLTQNVIVTERVICPVSSVP---GNLAGPT--PLPTQLRGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------ALLLTSL------
-----------VRDH-NAKNGTIR-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDRE------IY
CRALNA--QGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGL-YAESECSITIL-DVNDNIPYLEQSSNK--CR-NS----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
----GGQ--VVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHN-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
XAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPDP---SWPPQSTEPMCPQS-T--------E
PL------------------------------------------------GSG---HPPI
SPH----------FG--RTTVISENVY-PSGPGVQHPMPI-PDPLGY-GNVTVRESYATS
-G--TLK---PSVHFHDNQQTSNVVVTERVVGPVPDAD-LHGML------EIPDLRGGA-
NVIVT--------------------------ERVIAPGSSLPTSLAI-PNPRETSNVVVT
--ERVIRPTSGMIGN-LSMPPELSSAHNVTVTERVVSG-AGMSGIAGTAALG--------
--------GVGGVGSSGI-----VSTTMGAGG----------MGLSGA--GVGDGGTG--
---------L-------SMGGTATIGHMRSASDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MTWFLF---RTP-----GALAILMVLI--L
VH--GE-LRIETKDQ-HGEDDTAV--QG------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGMGIDQPPFGIFVVDKNTGEINITAI-VDREETPSFLIT
CHALNA--LGQDVEKPLILTVKI LDVNDNPPVFSQSIF VGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGIPMFLLSRHTGEVRTLTNSLDRE----QVSSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRESQ YS--AV-IKENTLSSELLRF---QV
IDWDEEFTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQIQ
NVKLGIAVKNKAEFHQSI-ISQYRVQSTPVTIQ IANVKEGITFRPASKTFTVQKGI-SSK
KL VNYVLGMYQAIDEDTNKPASYV-----KYIMGRNDGGLLFIDSKTAQIKFVKNIDRDS
TFIVNRTITAEVLA--IDE---NT-GKTSTGTIYVEVPGFNENCP-TIVLEKKTICS---
S-QPSVVVSARA-LDNKYSGPYTFSLEEQPLKLP-VVWSITTLNA--TSAL--LNAQQPL
SPGSHSISLTVTDSQDRQCETPESLTLE--VCQCDNRDTCRSSEKDKDP-----------
------------------------------------------------------------
-----------------------------GY------KAGNRTSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGM-GPIRG--VTGGFIPVPD
GS-------EGTIHP---W-GIEGAHPEDKE------ISNIRVP-PIT------------
-------------------------------ANGADF-MENSEVC--------TNTYAGG
T-V--VEGT---S--GMELTTKLGAATGSGAAGG------------FGGVTGLGIGSAGQ
S--GTMRTRHS-TGGTNKDYGEG-A-------VS-MNFLDSYFS----------Q---KA
FACAEEDDAQEANDCL---LIYDNE--G----MGAPGSPVGSLGCCSFIA-DELDDSFLD
S-----LGPKFKKLAEISLGIDE-EAQQFQPP---SKDSHLGMESCGY----SLGVQQP-
------------------------------------------------------------
---------ESVRGQTLSGSQGTSALS-ASSSVLQPAVSI-PDPLQH-GSYLVTETYSA-
SGS-LVQ---PSTTVSEPLLTQNVIVTERVIGPISNVP---GNLQTPM------EIRGSR
NMICI--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDKEEMAMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRNSQ YS--AR-IEENILSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGI-SSK
KLVDYILGTYQAIDEDTNKAASNV-----KYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS
AFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPDFNDNCP-TVVLEKEAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGICGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVL-PVT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGH----PIEVQQT-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLTISVXXX--X
XX--XX-XXXXVKEL-DMENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGVGVDRPPYGVFIINARTGEINITSV-VDREITPIFLIY
CRAL--NSRGEDLERPLELRVKV MDINDNPPVFTQSV YTASIEENSNANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPSGAPMFILNRYTGEICTISSFLDRE----QHSMYNLLVRGS
DRDGAIDGL-SSECECRIKIL-DVNDNFPTLEKTSXX--XX-XXXXXXXXXXXXX---XX
XXXXXXXXXXXX-----------XXXXX---------XXX-XX-----------------
-------------------------------XXXXXXXXXXXXXXXXXXXXXMLDYEQMP
NIHLTIGVKNQAEFHHSV-ASQFQMHATPVRVQVVNVREGPTFHPNSMTFSVQEGL-RGD
SLLNYVLGTYTAIDLDTGNPATNV-----RYTIGHDAGSWLKVDSRTGEIQFSREFEKNS
KYIINGIYTAEILA--IDD---GS-GKTATGTIRIEVPDVHDQCP-FISTESETICT---
S-FPSVFISA---EDHSYGSPFTFCVANQPPGTA-DLWDIRSINA--TSAI--LMAVQPL
LPIVYSIPIIVKDRYNRACEVPQIVQLQ--ACECDVNHVCFYSSTTSIYTGDV------S
------------------------------------------------------------
---------------SATGDIYGS----------VTDDQVGESNVGLGPTGIAMIILGIL
----LLL--LVPFMLL--------------------MCCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------SSPYTVLCYCS--TADGID----
--N----ASNTME------------------ATEAQTKPLISEIY--------TNTYAGG
GTV--EGGV---S--GIELDTGAG--TAAGLMAGG------------------------A
A--GATRKKSS-TIGTLREYAES-G-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESSME
T-----LDPKFKTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-LSEAGFQAEMAV-PEPVIP-GDIIVTGTYSTA
--DQCVP---PTTIVFDPQLAPNVVVTETVMAPVIDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAQLANTHNVIYAERVLPS-PGMTGTSSSSMPDG-------
--------CMGPMMSGS---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDICMSQT-----IGSTSPMT-SRHRVTQ
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILFMVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQEP
NIYLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFSPSSMTFSLRGGM-RGA
SLMNYVLGTYTAIDMDTGNPATNV-----RYVIGHDAGSWLKVDSRTGEIQFSREFDMKS
KYITDGIYAAQILA--IDD---GS-GRTATGTICIEIPDANDYCP-VIYAESRSVCT---
H-ASSVRIYV---NDHSFGSPFTFCVVDESPDIA-NIWDIRSING--TSAI--LMTEQTL
SPGPYQIPILVKDSHNRACELPQTVLLD--ACFCDDHHVCLHSSTTGIYTGDI------T
------------------------------------------------------------
---------------WVTDDMYGT----------VTDDGVRQSNVGLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TATGMVAAG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESYIE
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAAASEPMIH-GDIIVTETYTTS
--DPCVQ---PTTIVFDSQIPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGIPDMGNSNISDA-------
--------CIGPVMSGG---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PDIHISQT-----TGSTSPMT-SQHRVTR
YSNMHYSRQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DVENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLNSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQ VVNVREGPTFHPNSMTFSIREGI-KGN
SLLNYVLGTYTAIDMDTGNPATNV-----RYIIGHDAGSWLKVDSRTGELQLSREFDKKS
QYITNGIYTAEILA--VDD---GS-GKTATGTICIEVPDVHDYCP-VIFAESKYICI---
A-SPSILISV---YDHSYGAPFTFCVADQPPGTA-DLWDIRSINA--TSAI--LTAEQLL
YATVYQIPIIVKDSFNRACELPQIVELE--ACDCDYNHICLYSSTTGINAGDG------S
------------------------------------------------------------
---------------SVTSDIDGT----------ITEDQIEGSNVGLGPTGIGMIALGLL
----LLL--LAPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------DGVMQA---W-GIEGARPEDRD------VSNICVPM--T-----A------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLV--TAAGVAAGG------------------------S
A--GARRRRSS-TIGTQWEYADT-G-------LN-MAFLDSYFS----------E---KA
YAYADEDECRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAM-PEPMIH-GDIVVTETYTTA
--DPCVQ---PTTIVFDPQLAPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICIPAELANTHNVIYAERVLSS-PGMPDTSNGSMTDG-------
--------CMGPVMSGS---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PNIHVSQT-----TGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLILFMVVL--G
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVSQ--RITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIH
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTANIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILK-LV-----------------
---------------------------------------------------KMLDYEQEP
NIYLSIGVRNQAEFHHSV-ASQFQMHSTPVRIQVVNVREGPTFSPSSMTFSLRGGM-RGA
SLMNYVLGTYTAIDMDTGNPATNV-----RYVIGHDAGSWLKVDSRTGEIQFSREFDMKS
KYITDGIYAAQILA--IDD---GS-GRTATGTICIEIPDANDYCP-VIYAESRSVCT---
H-ASSVRIYV---NDHSFGSPFTFCVVDESPDIA-NIWDIRSING--TSAI--LMTEQTL
SPGPYQIPILVKDSHNRACELPQTVLLD--ACFCDDHHVCLHSSTTGIYTGDI------T
------------------------------------------------------------
---------------WVTDDMYGT----------VTDDGVRQSNVGLGPAGIGMIILGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMQP---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--TATGMVAAG----A--------------------
T--GTLRKRSS-TIGTLREYQDT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-A--------GSPVGSIGCCSWIV-DDLDESYIE
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAAASEPMIH-GDIIVTETYTTS
--DPCVQ---PTTIVFDSQIPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIANTHNVYYAERVVAS-PGIPDMGNSNISDA-------
--------CIGPVMSGG---------------------------------ILVGPEIQVT
Q---------MM-----------------S-PDIHISQT-----TGSTSPMT-SQHRVTR
YSNIHYSRQ----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------ALLLTSLVVL--E
VN--SE-FQIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTFL GQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAESECSITI L-DVNDNIPYLEQSS YD--IT-IEENTLHSQLLQI---RV
IDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLCIGVRNVAEFHQSI-ISQYRLTVTLITVTVLNVVKGCVFQPGSKTFIVDSR-----
MEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDS--GIITLRNRVTMEQ
YERLNKRYEGTVLS--IHD---SL-QRTCTGTIIMVLCGF-WTTT---------------
-----------------------------------------EHPT--T------------
------------------------------------------------------------
------------------------------------------------------------
----STEKP------------------------VTLSITPNVDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------SCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQP---G-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFI--EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPDP---SWPPQSTEPICPQH-M--------E
QL------------------------------------------------ASG---HPSI
SPH----------FG--KTTVISENAY-PSGPGVQHPMLI-PDPLGY-GNITVRESYTTS
-G--TLK---PSVHFHDNQQASNVVVTERVVGPISGAD-LHGML------EIPALRDGT-
NVIVT--------------------------ERVIAPGSSLPNSLTI-PNPRETSNVVVT
--ERVIQPTSGMIGN-LSIPP---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWSFFR--IA------AVLFIFL------
-----------VRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDAPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMDLPQNS--IE-IEENTLYTNLMQL---TV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSIGVRNKAEFHHSI-MSQYKLTATA VSVTVRNQREGSVFRPGSKTYIVTGN-----
MGA NSNVGDFIATDQDTGERSTT---AR--YVMGNNPADLLAVDSRTGIITLKNKITKEQ
YNMLGGKYQGTILA--IDD---DL-QRTCTGTININMQDFDFNGG---------------
-----------------------------------------DTTT--D------------
-----------------------------------------------------TESNTND
N--------------TDTNTGSS----------T-------------NNSREETSTQQGT
ST------------------------NVEGNSNSESSSSVFADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCDGAA--AR--SVGGFEPVPE
CS-------DGAMHV---W-SEEGPQFDPSN-----TV----CVPTI----SG-------
------------G-------------------ANLIEFVDNSGVY--------TNEYGGR
EMH-DMGGGGRV-----EQREEVNTSGMP------------------------ETCQ-EY
C--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---SWPPQSTEPVCPLQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--ATTVISESTY-PSGPGVQHPKPI-PDPLGY-GNVTVTESYATS
-D--TLK---PSVHVHDNRQASNVVVTERVVGPISGVD-LHGML------EMPDLRDAS-
NVIVT--------------------------ERVIAPSSSLPTSLTL-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-TGVTGISGTSGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGSGMGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MAQSPGGR---------CVLLLFLICF--N
VG---SGLHLQVLNT-RNGSNLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKRNP
VAKIHSDFEEEKGLKITYKYTGKGITEPPFGIFVFNKNTGELNVTSI-LDREETPFFLLT
GYALNE--RGVSIEKPLELRIKVLDINDNEPVFTQDVFFGSVEELSVANTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENEMLE--GM-VEENQANVEVIRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIIVTNKAAFHKSI-RSKYKPTSIPIK VKVKNVKEGIHFKSNVITVYV SE--SMER
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKIPDFES
RYVQNGTYTIKILA--ISE--DDL-RKTITGTIRIAVEDTNDNCP-TLTEPMQTVCH---
D-AQYVNVTAEDLDGYPNSGPFRFSVIDKPPGMA-EKWNIVRQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------RRDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------ICHCGKGVK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQKDSLAGRNG
VG-----GMA-KEAT-MKE---------SSSGSFAKGQREMSELD--GRWEEHRSLLSVR
ATQ--VTGATGAI-ISKETMKNTRA----T-----GASRD---------VA---------
-G----AQ-------------------TAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHIAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLDQKI-DIDMEIEQR--QKPATE----------TSM-NTASR
SLYEQTMVNS-------------------ENA-S--SGSSFP-----------------V
PKS--LQE---ANAEKVSQEIVTERSV-SSRQAQTVSTPL-PDPVTSGNM-MATEASYAT
-GSTMP----PSTVILGSRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAHYVMVR
ERESFLAPSSGVQPT-LAVPNL-AVGQNVTVTERVL------------------------
-------APASTLQSSYLI---PTENSVKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MDWSFFR--IA------VVLFIFL------
-----------VRDY-NTKNGTIK-WYS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDALMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEHSK YD--IE-IEENTLYTNLMQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVTVQNQREGPVFRPGSKTYVVTGN-----
MGANSKVGDFIATDQDTGGPSTT---AR--YVMGNNPADLLAVDSRTGIITLKNKITKEQ
YNILGGKYQGTILS--IDD---DL-QRTCTGTINIDIQDFDFNGG---------------
-----------------------------------------ETTT--D------------
-----------------------------------------------------SD-----
---------------TNTNTGSS----------T-------------NNSREDNFTPQET
ST------------------------TWDEVPTSQLDVPLFSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGAA--AR--SVGGFEPVPE
CS-------DGAMHV---W-SEEGPQLDVIY-----DR----LKKI--------------
---------------------------------N-VIRSTLLGVY--------TNEYGGR
EMH-DLGGGERV-----EIREEVNTSGMP------------------------DTCQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---SWPPQSTEPVCPPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-PDPLGY-GNVTVTESYTTS
-D--TRK---PSVHIHDNRQASNVVVTERVVGPISGVD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTL-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-TGVTGISGTSGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGSGMGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
----------------------------ICLLQGEKCK-----TFICAKFYNCSICL--N
YG---SGLHWKVYDRSG-RSGMLSH-PN-----SLVRQKREWTVPPAFIREEEDNSYRNP
IARIHSDR-EDAGIVVIYTISGQGVTEPPYGLFVIDGKTGNLNITGK-VDREKTPMLFLR
GHALDK--NGAKLEDPIDLPIKI LDINDNPPVFSHEV FVGSIEELSETGTIVMKINATDA
DEPNNLNSKIAFRIISQNPS--SAFSMNKDTGEVRVATINLDRE----TQSSYSLVVEAK
DLGGASGGN-KATCSLEIKI L-DVNDNLPVVQGHA FE--GS-IEENRANVEIMRI---KV
FDKDEEFSDNWLANFSFVSGNEGGFFRIVTDTKTNEGILT-LV-----------------
---------------------------------------------------KELNYEEMQ
SLNLGVVVTNKAEFHKSI-KNSYKAQTIPIKIKV INVREGPVFPGGT KIITASES-----
LRVTQIIGQYQALDEDTGKVATNI-----KYIKGRDVANWININTVTGEIQLAKSLDYES
QHVVNGTYTFTMLG--VTT--DLP-AKTVTGTVVIQVKDENDNCP-IIENPVQTVCS---
D-AKLIDVTASDLDNYPNSAPFTFTIIDEPEGTA-KNWIIAYRND--TSVQ---LVPQNL
KVGRSEVPLLIRDFQGLSCAQRQSLQLT--VCTCAADGGCKDK-L---------------
------------------------------------------------------------
---------------------------------------ISNASVGLGPGAVALIILAFL
----LLL--LLPLLLL--------------------LCPCGSGAK--GF------AAIPD
CS-------EEMLRK---W-NSEGAAPEEKP------LQSIIPPTALGNSKGVT------
-----AGGGMSAEEA--------AA-CGGSSASNVRGHC-SIVTR--EGWEEQRHLLSGA
DYH--ARAAA---AGAVEGMA---------------------------------------
-A----GEGN--VVAAGR--G---MAMGTAGAMN-EEFLRDYFN----------D---KA
VSFAEEDEAQAARDCL---LVYSQGE-S--------GSPHGSIGCCSFIE-GDFDDHFLD
D-----LGDKFKTLAEICIGRHI-DMKD---------------GSSRNESAFGVHDASSQ
LLNQQKAFSS-------------------KQAFS--SGSHFS-----------------S
VPP--AQAGGGVGQEAVSQEVITETTFSS-RSGQHDVCPH-PTS-YAETNVTMTETSYSA
-GGPAH----PAAVFIDPQFSENVVVTERVLAPASSLQ---GMV------EIPD-LPSGS
NVVVT--------------------------ERMVKSEGPRAGTMT-VQDLTDSKYVVVR
ERERVLVPAGE-QGS-LSFPAL-SEGQSVVVNEKVLTT-SGGAGRAE-------------
-----------------RA---DGASAGRQEH-----VLITDSLLNQVGSAVEGAPP---
----------------------------------------------AS-STLSKSSRVTK
YSTVQYTRS----------------

------------------------------------------------------------
------------------------------MDWLFFR---NF-----CLLIILVVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANVLVVKLCATDA
DEENHLNSKIAYKIISQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQVVNVREGPAFHPSTMAFSVREGI-KGS
SLLNYVLGTYTAIDLDTGNPATNV-R--NRYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---NEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGSYEIPILVKDNYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------ATEDQAGVSNVGLGPAGIGMMVLGIL
----LLL--SVAPLLL--------------------LLCCCKRRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAP-------MT-------
-------------------------------ASNTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TATGLMAAG----AAGAAG--------VAGVAGA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAV-SEPVVH-GDIIVTETYGTA
--DQCAQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADCNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VGSTSPMI-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
-------------------------------------CTCNF-----ILFNCLQVFV--L
VH--GE-LRLE---P-HGEDETAVH-PG------KRRYKREWIKFATPCREREDNSKRNP
IAKITSDFQKTQ--KITYRISGVGIDQPPFGIFIVDPNTGEINITAI-VDREETPSFLIT
CRALNA--LGHEVEKPLILTVKI LDVNDNAPVFSQSIVK GEIEENSASNSLVMILNATDA
DEPNHLNSKIAYKIVSQEPSGTPMFLISRNTGEVHTLSNALDRE----QFSSYRLVVSGA
DQDGAG--L-STQCECDIK VK-DVNDNFPVLKHPQ YS--AR-IEENTVNSDLLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGKWFEIETDPRTNEGILK-VI-----------------
---------------------------------------------------KPLDYEQIQ
NMQFSIAVKNKAEFHRSV-VSQYQVQPTPVIIQ VINVKEGISFRPASKTFTVKKGI-SSK
KLINYIVGTYQAIDEDTNTASSSV-----RYVMGRNDGNLLTIDSKTAQIKFVKNIARDS
TFIVNKTITAEVLA--IDE---IT-GKTATGTVHVEVPGFNDNCP-PVLLEKDEICS---
S-SPSVTVSARTLERDRYMGPYRFSVEEQPLKLP-VVWRITSLNA--TSAL--VKAQQQL
SPGVYRVPLTVTGNEEQKCESSETLTLT--VCQCDDRGSCRASNTDPHI-----------
------------------------------------------------------------
-----------------------------Q---------PQRQLSRLGPNAIGLILLGLL
----LLLAWCHPQWLL--------------------HCPCSSVGPTGG--VAGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TNGVD-IVESSEVC--------TNTYTGG
T-V--VDGV---S--GMELTKVGAA------ASGF------------G-------SAAGH
LGLETMRTRHS-TGGTLKDYAEG-A-------IN-INFLDSYFS----------Q---KA
FACAEEEGVQETNDCL---LIYDDEG-I----DDAPDSPVGSLGCCSFIV-DDPDDSFLD
S-----LGPKFKKLAEISLGIDK-EAKQVQPP---PSYSGAGIDHKSQ----SYGRPQ--
-----------------------------------------------G-SCGQPLGVDPC
SRPIEVQQSELERYQTFLGSQGVHASS-TYGS-LQPAIPI-PDPLQQ-GNYLVTETYAA-
TSS-FMQ---PTTAVFDPLLTQNVTMTERVICPLSNIP---GST----------DPRGSC
NMLCT--------------------------ED-----------PC--------------
--SRQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHSFR--AA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMST FVGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMELPS QS--IS-IDENALYSDLLQI---RI
IDLDEEYSANWMGVIFFISGNEGGWFDIEMNERTNVGILK-VI-----------------
---------------------------------------------------KPLDYEDVK
SLQLSLGVRNKAEFHHSI-MSQYKLTATAITVTV LNVIEGPVFRPGSKT YVVTSN-----
MGQNYKVGDFIATDQDTGRASTT---V--RYVMGNNPANLLDVDSKTGIITLRNRVTREQ
YNMLGGKYQGTILS--IDD---TL-RRTCTGTINIDLQGSGWVEN---------------
-----------------------------------------GKVT--D------------
-----------------------------------------------------STST--G
SSEGSSTAGGE-VTGTGSVNGAD-------------TS--SNTGDK-TYSDVTGT-----
----------------MPLD-------------NGFEESKFSDNVHFGPAGIGLLIMGFL
----VLGSTVVPFLLM--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPPPVD-----VT-TVCVPPIP----PD-------
------------N-------------------ANLIECIDTSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTEGVKTSGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------QQIQKA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDVDDSFLD
T-----LGPKFKKLADISLGKEV-EPYPDPDP---SWPPESTEPICPQQGT--------E
PI------------------------------------------------SGG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PSVHVHDNRHASNVVVTERVLGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTM-PDPRESSNVVVT
--ERVIRPASGMMGN-LSIHPELSNTQNVIVTERVVSG-SGISGISGPAGMS--------
--------GGSGLVG------------------------------SAG--GVSGGGMGLS
SLGGGGGLSS-------GMGGTATIGHMRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPIFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIH VINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVTVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDTQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYAEG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLFP---RPT-----GALAIFMVVM--L
VH--GE-LRIETKGQ-YDEEGMVVQ-QA------KTRHKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVERPLILTVK ILDINDNPPVFSQSIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QTSSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPILKESQ YS--AR-IEENTLSSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
RL VDYILGTYQAIDEDTGKAASNV-----KYVMGRNDGGYLMIDSKTAQIKFVRNMDRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVKVPSFSDNCP-TAILEKDELCS---
S-SPSVVVSARIPD-NRYTGPYTFSLEDQPVKLP-AVWSITTLNG--TSAL--LKAQEQI
APGVYHISLVLTDSQNNHCDMPDSLTLE--VCQCDNRGTCGTFSPTIDP-----------
------------------------------------------------------------
-----------------------------GT------RVGRSFPGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDYGG-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------GNGADF-MESSEVC--------TNTYARG
T-V--AEGA---S--GMEMTTKLGAANGSGSATGFAAGTVSAAAAGFGAATGLGICSSGQ
S--GTMRTRHS-TGGTYKEYAEG-A-------IN-MNFLDSYFS----------Q---KV
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGIDD-EGKQVQPP---SKDRCYGTESCGH----SKEVQQL-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VLPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT--QLPTQLRGSR
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------SHCLYP---S--------------------
-----------MKEQ-HQEDPAAV--QH------IRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQASQ--RITYRISGVGIDQPPFGIFVVDPNTGDINITAI-VDREETPSFLIT
CRALNA--LGQDVERPLMLTVKI LDVNDNSPVFSQSIF QGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGMPMFLIGRNTGEVRTLTNSLDRE----W IKDT-------
------------------------DAHKLCLSPFQ YS--AR-IEENTLNSEVLRF---QV
TDWDEEHTDNWLAVYYFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KPLDYEQVQ
TMQFSIAVRNKAEFHQSV-ISQYRVQSTPVTIQI TNVREGISFHPTSKTFTVKKDL-STK
KL IGYILGTYQAIDEDTRKAASSV-----RYVMGRNDGGFLTVDPKTAQIKFVKNIDRDS
TFIVNKTITAEVLA--IDE---NT-GKTSTGTVYVEVPSFNENCP-SVVLEKNEICS---
S-SPSVVVSVRTLDKAKYAGPYTLSLEEQPLKLP-AVWTITTLNA--TSAL--LRAQQQT
SPGEYDISVIVKDHLGGQCETPESLALT--LCQCDDRSVCRTSNPSRDP-----------
------------------------------------------------------------
-----------------------------LI------T-RGESSGRLGPAAIGLILLGLL
----LLL--LAPLLLL--------------------TCDCGT-GPIGG--VTGGFIPVPD
GS-------EGTIHP---W-GIEGAQPEDKE------MTNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------AHTYTGG
T-M--AEGT---S--GMEMTTKLEAAAGSGAA-----------------ASGLGFSSLGQ
T--GTMRTRHS-TGGTLKDYAVG-T-------VN-MNFLDSYFS----------Q---KA
FACAEEEDEREVSDCL---LIYDNEG-L----DDAPGSPVGSLSSCSFMA-EDLDDSFLD
S-----LGPKFKKLAEISLGIDE-ETRQAQRA---PKDSGSGADARGR----TLEAQQLA
RTV---------------------------------------------------------
----------------SAGQGAAALST-AAGS-VHPAVAI-PDPLQH-GNYVVTETYSA-
SGS-FVQ---PVSGALDPHLAQNVVVTERVVCPRASLA---ANLAVPA------ELREPC
GGLYP--------------------------AG-----------PC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
---------------------------------------AFFML---IFLSFLQVLL--D
FS--TG-FHVEV-KE-WNGNGTAR-WKT------FRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEENN--PVTYSISGVGIDRAPYGIFVVNPRTGEINITSI-VDREVTPVFVIR
CFAKHS-VTGMDLEPPLELRVRV LDINDNPPIFAQSV FTGSVEECSMDNTLVMKIIASDA
DEPNHLNSKIAFKIESQEPSGQPMFIMNKYTGELH-LANYLDRE----QHSSYTLVVKAS
DRDGAADGI-SSHCSCHVKV I-DVNDNFPTLAQSS FS--AS-ISENSLSSEILRI---QA
LDADEEFSDNWLAEFFFISGNEDNYFEIVTDPATNQGILR-VI-----------------
---------------------------------------------------KELNYEHIP
THSLSIGVRNRAEFHHSV-MSQYQVIGTPLIVEV KNVIEPPIFNPSA MILSVPQR-----
TRVNYVVGTYTAFDEDTGTTANNV-----IYSIGRDPGAWFRINQNTGEITLSKVIDWES
SYVRNGQYTAEVLA-ITRG---VP-RYTATGTIVLTMQDTRDNCP-AINTELRNHGN---
K-NEENH---------QYDNN-----------------------------E--SV-----
---ILNITVNT------------AIP-----------------------NSGNKSGTGSN
-----PVPTPA----------------------------AAPGPQP--------------
-------------------------------------------QQSLIDIKIGITQKGSL
----FCN--INHMGTTNKR----------TITNDCG----GP-GMKSG----LGFKATTT
ST-------TSSYHH---P-APPPAPPPPPM------ITTFVAPLLHT------------
-------------------------------GGI--TYFLFADIY--------TNTYGGG
G-V--VA-----S--GVE----E------TTGVGYGTGTGYGTAG-------------GI
S--GTGEAKGSV-GGTIKEYREG-G-------VN-MAFLDNYFS----------E---KA
FVYADEDEGRPANDCL---LIYDHEG-I--------GTPVGSVGCCSFIG-EDTDETYLE
T-----LGPKFKTLAEICLGKEI-EPFPDANP---PWPGI-N-----------VTFPNSE
CDLNLPPPGT-------------------------------------TILVNGS---APM
APP----------AGT--TTVVTENTY-TSASTVQPPRPM-PDPLLH-GNVTVTETYASG
--S--------PSLCVDPLRASNVVVTERVVGPASASD-LRGML------DIPDLADGS-
NVIVT--------------------------ERVIAPNSRLPASLSI-PDLVDGSNVVVT
--ERVFRPASGMPGSLINIPSELSNAHNVVVTERVVSG-SGMSNLAGG------------
--------------GLG-------------------------------------------
---------------GASLGGLSSTGQM-LNADCHLGQA-----MGTASPGT-SRRRVTK
YSTVQYSS-----------------

------------------------------------------------------------
---------------------------MASSKLCRFM---LM-----WYLLLKQVVM--E
VN--SE-FIVEVKEF-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESSQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELLRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGPAFHPSTMAFSVREGI-KGS
SLM NYVLGTYTAIDLDTGNPATNV-----RYIIGHDAGSWLKIDSRTGEIQFSREFDTKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDINDYCP-NIFPERRTICI---
D-SPSVLISV---HEHSYGSPFTFCVVDQPPGTA-DMWDVRSTNA--TSAI--LTARQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGATGIYTEDV-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LAPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRD------VSNICAP-------MT-------
-------------------------------ASNTQDRMDSSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAAGAA--G----VA-----------------GA
A--GAARKRSS-TMGTLRDYADS-D-------VN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----VDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEAEFQEEVAA-SEPVVH-GDIIVTETYGTA
--DQCVQ---PTTIIFDPQLAPSVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDV-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MV-----------------S-PDLPISQT-----VDSTSPVT-SRHTVTR
YGNIHYTQQ----------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILTVVL--E
VN--SE-FIVEVKEL-DIEKGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEANQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAIDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEESTDNWLAKYLILSGNDGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NIHLGIGVKNQAEFHHSV-ASRFQMHSTPVRIQ VVNVKEGPAFHPNSMIFSIREGI-RGN
S LLNYVLGTYTAIDLDTGNPATNV-----RYVIGHDAGSWLKVDSRTGEIKFSREFDKKS
KYITNGIYTAEILA--VDD---GS-GKTATGTICIEVPDVNDYCP-VVFAESEYICI---
D-SPSILISARDISDHSYGSPYTFCVVDQPPGTA-DLWDIKPKNA--TFAI--LTAKRRL
SPMLYQIPIIVKDSYNRACELPQIVVLE--ACDCDNDHICLYFSTTGINTGDG------S
------------------------------------------------------------
---------------SVTSDIYGS----------VTDDQLGSSNVGLGPTGIGMMALGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------DGVMQS---W-RIEGAHPEDRD------VSNICVPM--T-----A------
--------------------------------SNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TAAGLAIED------------------------A
A--GAR-RRSS-TIGTQWEYADM-G-------LN-MAFLDSYFS----------E---KA
YVYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-QQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNDSSGMT-LSEAEFQAEMAI-PEPIIH-GDIVVTETYSTA
--DQCMQ---PTTIVIDPQLAPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANAHNVIYTERVLSS-PGMPDVNSSTMTDG-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PNVHISQT-----TGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MMGLFP---RPT-----GALAILMVVM--L
VH--GE-LRIETKGQ-YDEDAMVLQ-HA------KTRHKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNV--QGLDVERPLILTVK ILDINDNPPVFSQSIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QTSSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPILKESQ YS--AR-IEENTLSSELLRF---QV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ IINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----KYIMGRNDGGYLMIDSKTAQIKFVRNMDRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVKVPSFSDNCP-TAVLEKNELCS---
S-SPSVVVSARIPN-NKYTGPYTFSLEDQPVKLP-AVWSITTLNG--TSAL--LKAQEQI
TPGVYHISLVLTDSQNNRCDMPDSLTLE--VCQCDNRGTCGTFNPTINP-----------
------------------------------------------------------------
-----------------------------GT------MRSRSFPGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-V--TEGA---S--GMEMTTKLGAANGSGSAAGFAAGTVSGAAAGFGPATGLGICSTGQ
S--GTMRTRHS-TGGTNKEYAEG-A-------IN-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDD-EGKQVQPP---SKDTGYGTESCGH----SKEVPQP-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---SNLAGPT--PLPTQLRGSR
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MKINATDA
DEPNTINSKISYKIVSQEPNYPPVFHLNKDTGEISTTSFKLDRE----EQSSYTLIVEAR
DGNGQITNKPVKQAQVQIRV L-DVNDNIPVVENEA YE--GS-VQENQANVEVMRI---RV
FDLDEVGSDNWLANFTFASGHAASYFHIETDTLTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSIVVTNKAAFHKSV-KNTFKPTPIPIRVKV QNVQEGIRFKSST ITVHASE--HTDR
SSQGRIIGKFQVFDEDTGKTT-RV-----KYTKWEDVDNWISVDTRTSEIKLVKIPDFES
KYVINGTYTTKIIA--VSE--DYP-RKTITGTIVIMVEDINDNCP-TLVDPVRSVCY---
D-APYVNVTAQDRDGHPNSGPFTFSVIDKPPGMA-EKWKIVQQES--TSVL---LQASER
KLGR-EIHFLIKDAQGFNCPEDQVLQLR--VCNCLDGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------LHDSYVGLGPAAIALIIFALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------AAVPG
-T-------MEMLHP---W-NNEGAPPEDKA------MPLLPPPPLPAGDPRGNLSSESG
VG-----CSFTKGAA-GKG---------SFSASVSKGFHETSEMD--GRWEEHRSLLSGG
AAQ--VTGAAGHV-LSKETIRTTRA----T-----GMTRE---------FA---------
-G----AQ-------------------TAAAVLS-EEFLGSYFA----------E---KA
ASYVDEDDLHTAKDCL---MVYSQEA-P--------DSPHGSLGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCMGQKI-DMNVDMEQR--QKSVAE----------ASV-STASR
SHAEQTVVHT-------------------GNA-S--SGSSFH-----------------V
AKP--VHA---ANTEKVFQEVVTERSV-SSQQGHQVATPL-PDPLVPSSL-LVTETSYAT
-GSTIP----ASAALLGARQPQGLIVTERVYAPSSTVM-------------DQH-SASAS
NVLLT--------------------------ERVIQPNEGVLSPLQVPQCLPDAHYVMVR
ERERVLAPGSGVQPP-LAMPRV-AMGQNVTVTERVL------------------------
-------TPASTLQASYQA---PVEASVVTRK-----V-----KVSGT--SVTGPVPKF-
--------------------GLEESLSSSALPA-----------PPTGSA----------
HSTGQHRPTHS--------------

------------------------------------------------------------
------------------------------MNWPFFG--AA------VVLLIFLVVL--E
VN--SD-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--LGQDLEKPLELRVRV LDINDNPPVFSMSTF VGEIEENSNANTLVMVLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYIELPTQS--IS-IEENTLNSNLLQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDFEAMN
NLQLSLGVRNKAEFHQSI-MSQYKLTATAVSVTVLNVIEGSVFRPGSRTFAINSN-----
MGQNYKVGDYVALDLDTGRPSTT---V--RYVMGRNPTDLLAIDSKTAAITLRNKVTMEQ
YKILGGKYEGTILS--IDD---AL-QRTCTGTIIIDLENGGWETD---------------
-----------------------------------------RTNL--S------------
-----------------------------------------------------GSTTTEY
GLTSR---HVATNGYTT-GVG-----------------------ID-KNTYAGD------
-------T-------------------NGYAGGQPGVYQPLGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDYGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGAQADPGA-----LT-NIGVPCIP----GT-------
------------N-------------------ANVIEYVDNSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTDGVKMSGGP------------------------EICQ-EY
P--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-A--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKDV-EPFPDSDP---SWPPDSTEPVCPPQGT--------E
PT------------------------------------------------GGG---HPPI
SPR----------FG--TTTVISENTY-PSGPGVQHPTPI-PDPLGY-GNVTVTESYTSS
-G--TLK---PAVHIHDNRHASNVVVTERVVGPISGAD-LQGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTTLTI-PDPRQSSNVVVT
--ERVIQPTSGIVGN-LSMHPELSNTHNVIVTERVVSG-SGITGSSSLLG----------
---------------------------------------------SAG--GGSGGGIGLG
SLGGGAGLSS-------SLGGTATIGHLRGSSEHHFSNT-----LGSASPTT-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MNWPFFR--TA------AVLFIFLVVL--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLERPLELRVRV LDINDNPPVFSMSTFL GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECSIKI L-DVNDNIPYMELPSNS--LQ-IEENSLNSNLLQI---RV
IDLDEEFSANWLAVIFFISGNEGGWFDIEMNERTNVGTLK-IV-----------------
---------------------------------------------------KPLDYEEVK
NLQLSLGVRNKAEFHQSI-MSQYKLTATAISVTVLNVIEGSVFRPGSKTYVVTSS-----
MGQNYKLGEFIATDLDTGLPSTT---V--RYVMGNNPTDLLAIDSKTGIITLRNKVTREQ
YNLLGKKYQGTILS--IDD---AL-QRTCTGTINIDLEGSGWEDR---------------
-----------------------------------------QTDG--A------------
-----------------------------------------------------VTGG---
----------GTITSTND--------------------------FT-PSYEYTTT-----
----------------NTEDV-----YSVTPTGNGVRVRDPLDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLM--------------------YCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGAQPERAD-----LT-TICVPQVP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-ELGGGERTT--GFELIDGGKISGAP------------------------EICQ-EH
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-E--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKET-EPYPDPDP---SWPPQSTDPICPPQGT--------E
PI------------------------------------------------GSG---HPPI
SPH----------IG--TTTVISESTY-PSGPGVHHPMPI-PDPLSY-GNVTMTESYTTS
-G--ILK---PSVHVHDNRQASNVVVTERVVGPISGAN-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPNSSLPTTLTI-PDPRESSNVVVT
--ERVIRPTSGIVGN-LSMHPDISNTHNVIVTERVVSG-SGITGISGGSGM---------
--------GSSGLVG------------------------------STA--GVGGDGLGLS
SLGG-GGLSS-------GIGGTATIGHLRGSSEHHFSNT-----LGSASPTT-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPTSKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYAEG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTSSGGQGASALS-SSGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
-------------------------------SVNPGE---------CRFLSLALICF--Y
FG---NGLHLEVLNA-RNGNTLLPK-HR-----HLVRQKRAWITAPVALREGEDLSKRNP
IAKIHSDVAEERGLKITYKYTGKGITEPPFGVFVFNKDTGELNVTKI-LDREETPSFLLI
GYALDE--KGNNLEKPLELRIKVLDINDNEPVFTQDVFAGSIEELSAADTLVMKISATDA
DEPNTLNSKISYRIVSQEPTYPPVFYLNKDTGEIYTTSFTLDRE----EHSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVVKNEMNE--GV -VEENQANVEVMRI---KV
FDADEIGSDNWLANFTFVSGNEMGYFHIETDTQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEVK
NLDFSIVVTNKAAFHKSV-KN KYKPTSIPFKIKVKNVKEGIHFKSSTVSVHVSE--SMDK
SSQSQIIGKFQVFDEDTGQQA-RV-----KYAKLEDIDNWISVDSVTSEIRLVKIPDFES
RYVQNGTYTAKILA--ISE--SYP-RKTITGTVVITVEDINDNCP-TLVDPVQNICD---
D-EQYVNVTAEDLDGPQNSGPFSFSIIDKPAGMA-EKWQIVHQES--TSVL---LQQKEQ
KLGRSEIQFLISDSQGFSCSEKQVLQLT--VCKCLDGSGCVEP-----------------
------------------------------------------------------------
---------------------------------------LRGTYVGLGPAAIALIIFALL
----LLL--LVPLLLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPLHLTA-----DHGESVAADIR
LG-----VVTTKETT---K---------ESSSALIKDHHEMSEID--GRWEEHRSLISGG
VTQ--VTGTTGAN-IGAEALRITKA----T-----GSSRD---------LA---------
-G----AQ-------------------AAAAAVN-EEFLKSYFT----------E---KA
ASYTDEDDIHTGKDCL---LVYSQED-T--------ASLHGSIGCCSFIE-GELDDGFLD
D-----LGFKFRTLAEICLGQKI-DMDVEMEQR--QKHAGE----------SSM-KAASH
SFSEQTNINS-------------------ENAYF--SGSSFQ-----------------V
PKP--LDE---ANAEKVTQEIVTESSV-SSRQGHKVATLL-PDPLASGNV-VVTETSYGT
-GSTMP----PSTVVLGPGQSQALIVTERVYAPAPPLV-------------EQR-YANDT
NVMVT--------------------------ETIIQPNGGFPGPLEGTQHLPDGRYVVVR
ERESFLAPRSGAQPT-LAMPGV-AVGQNMTVTERVQ------------------------
-------TP----ASSYWI---PAQTSVMARK-----T-----EVSGA--GVRGPLPNC-
--------------------SLEESGHSNSMLT-----------GHSNSTLTASSTRVSK
HSIVQHSYS----------------

------------------------------------------------------------
------------------------------MDWHPFR--TA------VVLLIFLVVV--E
IN--SE-FRIQXXXX-XXXXXXXX-XXX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-VDREVTPFS-IV
CRALNS--MGQDLERPLELRVRVLDINDNPPVFLMSTFIGQIEENSNAXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKIL-DVNDNIPYMEQSSYV---N-IEENAXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVAVSNVIEGSVFRPGSKTFVVTSN-----
MGQGYKLGGFPAIDLDTGLASTT-----VRYVMGNNPASLLDVDSKSGMIILRNRVTWEQ
YKMLNGKYQGTILS--IDD---NL-QRTCTGTVIIDLDGSGWEEV---------------
-----------------------------------------VTNT--E------------
-----------------------------------------------------PNTNTN-
------------------------------------------------------------
------------------------------TNTGQTGGGTSTDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGG---AG--GGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD------IATICVPQMQ----PD-------
------------N-------------------ANIIEYTDTPGVY--------TNDYCGR
EMQ-DLGGGERTT--GFEIADGVKT--GQ------------------------EICQ-DY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEEEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISMGKEI-EPYPDPDPTCPAWPPQSTEPVCPPQGT--------E
PI-------------------------------------------------SG---HPPI
SPH----------FG--KTTVISESTY-PSGPGVQHPMPI-PDPLGY-GNVTLTESYATS
-G--TLK---PSVHIHDNRHASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-PNPRESSNVVVT
--ERIIQLTSG---R-LGMHPELSNAHNVIVTERVVSG-TGVTGISGTAGISG-------
--------G------TGL-----GGTSRGTSG----------GGLSGA--GVSGGGIGLS
-----------------SMGGTATIGHV-SSSDHHFNQT-----LGSASPRT-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------ALLLTSLVVL--E
VN--SE-FQIQVRDH-NAKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--PVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTFL GQIEENSNANTLVMKLNATDA
DEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAESECSITI L-DVNDNIPYLEQSS YD--IT-IEENALHSQLVQI---RV
IDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLK-VV-----------------
---------------------------------------------------KPLDYEAMK
NLQLSIGVRNVAEFHQSI-ISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSR-----
MEANHRVGEFVATDLDTGRAST-----NVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQ
YQRLNGEYKGTVLS--IDD---SL-QRTCTGTIVIELSGTGWVTG---------------
-----------------------------------------SESG--G------------
-----------------------------------------------------SSSGSGD
DRDRVTNGYQGTSSTENPQRVTGSW----------------------GGSGIDG-TRPNT
NPF-QGDPD------------------------ETLETPLYGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHE-----GITTICVPQMP----PG-------
------------N-------------------ANVIEYIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDSDP---SWPPQSTEPMCPQH-T--------E
PL------------------------------------------------GSG---HPPI
SPH----------FG--TTTVISENAY-HSGPGVQHPVPI-PDPLGY-GNVTVRESYTTS
-G--TLK---PSVHFHDNQQASNVVVTERVVGPISGAD-LHGML------EIPDLRGGA-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PNPQETSNVVVT
--ERVIQPTSGMIGN-LSMTPELSSAHNVIVTERVVSG-AGMSEIAGTAGLG--------
--------GVGGIGSSGL-----VSTTMGASG------------------------TG--
---------L-------NMGGTATIGHMRSSSDHHFSQT-----VGSASPSM-ARSRITK
YNTVQYSK-----------------

------------------------------------------------------------
------------------------------MARSPGRP---------SALLLVLICF--H
FG---NGLHLEALNT-RHENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDIAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--KGNSVEKPLELRIKVLDINDNEPVFTQDIFVGSVEELSAAHTLVMKISAVDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EHSSYTLTVEAR
DGNGQVTGKPVKQAQVQIR IL-DVNDNIPVVENEV YE--GT-VEENQVNVEVMRI---KV
FDADEIGSDNWLANFTFASGGGEGYFHIETDTQTNEGILT-LI-----------------
---------------------------------------------------KEVDYEVMK
NLDVGIIVTNKAAFHKSI-RNKYKPTSIPIK VKVKNVKEGFYLKSSTISVHASE--SMER
SSRGQVIGKFQALDEDTGRQA-RV-----KYEKLEDIDNWVFVDSVTSEIKLAKIPDFES
RYVHNGTYTVKILV--ISE--DHP-RKTITGTVVITVEDINDNCP-MLVEPVQNICN---
D-VQYVNVTAEDPDGYPNSGPFRFSIIDKPQGMA-EKWKIVHQES--TNVL---LQQSEQ
KLGRSEIQFLISDNQGFSCPEKQILTLT--VCECLDGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------FRDSYVGLGPAAVALMILALL
----LLL--LVPLLLL--------------------VCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLPV-----DQGDILAVRSG
AG-----GLT-KELT-MKG---------SNSASVAKGQHEMSEVD--GRWEEHRSLLSGE
TTQ--VTGTTGII-MGPETIRTTRA----M-----GASRD---------MA---------
-G----AR-------------------AATVVLN-EEFLRSYFT----------D---KA
TSYTEDDENHTAKDCL---LVYSQEE-T--------ESLHGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DTDMEIEQR--QKSVTE----------TSM-NTASR
SLYEQTRVNA-------------------ENAHF--SGSSFP-----------------V
AKP--LHE---AKAETVTQEIVTERSV-SSRQAQKAAPPL-PDPLASGNV-IVTETSYAT
-GSTVP----PSTVILGPRQPQSLIVTERVYAPGPTLV-------------DQH-YANEG
KVIVT--------------------------ERVIQPNGGLLNPLEDTQHLQDAGYVMVR
ERESFLAPSTGVQPP-LAMPSV-SVGQNVIVTERVL------------------------
-------TPASTLQSSYQI---PTENSMKARK-----T-----LVSEA--GVTDPPPNF-
--------------------GVEKSGHSNS-------------------TITTSSTRVTK
HSTLQHSYS----------------

------------------------------------------------------------
--------------------------------YH--FIHYI------IFYYTLSVVV--E
IN--SE-FRVQVRDY-NSKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAKNQ--QVTYRISGVGIDQPPYGVFIVNPKTGEINITAI-VDREVTPFFIIY
CRALNV--NGQDLERPLELRVRV LDINDNPPVFSMTEF VGSIEENSYANTLVMVLNATDA
DEPNNLNSKIAFKIISQEPSDAPMFILNRYSGELRTMNPFLDRE----KYATYSLVVRGS
DRDGAVDGL-SAQSDCRIT IL-DVNDNFPRLERPT YT--IN-IQENMISQEVMRF---RV
IDLDQEGTDNWLALFFFISGNEGNWFEIVTDEMTNEGIFK-VI-----------------
---------------------------------------------------KPLDYEEIQ
NLQLSIGVRNKAEFHHSV-ISQYKIEATLISVSVENVIEGSVFAPASNTYIITKN-----
MRKNDVIGSMVAIDLDTRGPSKT-----VRYIMGTNPGGLLAVNERTGQLILQNTITRDV
YQRIGGRYEGTILS--IDD---TL-QRTCTGTILLDLSQLDGGIN---------------
-----------------------------------------GGSG--G------------
-----------------------------------------------------SGT----
G--GSSGGDGSDGGGSREDTHTD---------------------GP-G-TSN------VT
-----------------TNPT--------GPLNPGLDRQTLGDNVHLGPAGIGLLVMGFL
----ILG--CKYFIYL--------------------SSVYRGT---SS--H----ISLPS
IN-------IGSICH---ANMEEGPIPFNSN---------IIIQLYQMEK----------
------------Y------------------NALGIHCSLESNKL---------------
------NKGMGKV--KKKDLEGGKKIFSF------------------------IICF-KK
S--VK----------TKQKQKKG-Q-------FNMFNSIHNLFI----------F---KA
FAYADEDEGRPSNDCL---LIYDIEG-V--------GSSAGSIGCCSFIG-EDEDDSFLD
T-----LGPKFKKLADISLGKEI-DSYPDVDH---TWPPENTEPSCPPQGN--------D
IP-------------------------------------------------VG---HPPM
SPH----------FG--TTTVVSESTY-PSGPGVQHPVPI-PDPLGY-GNVTVTESYTTT
-G--SLQ---PQVPIHD-RNSSNVVVTERVVGPISGPD-FQDML------NLTDFREGS-
NVVVT--------------------------ERVIAPNSRLPTSLNI-YDPRDTSNVVVT
--ERVIRPTSGLMGN-LSIHPDLSSAHNVVVTERVVSG-AGVT----GGGVSG-------
--------MVGSNVSRGAITMSGAGVSMSGGG----------IGLSGS--GINGGGIEMS
SLG-----------------GSSTLGHVRNS--DHFNQT-----IGSSSPST-TRSRITK
YSTIQYSK-----------------

------------------------------------------------------------
------------------------------MSWLFP---RAT-----GALAIFMXXX--X
XX--XX-XXXXTRGQ-HEEDVTAVQ-HT------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDRNTGDINITAI-VDREETPSFLIX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX----XXXXXXXXXXXX
XXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXYS--AQ-IKENTLNSELLRF---QV
IDWDEEYTDNWLAVYYFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALYGLQV-
---FSIAVK---QFHQS--ISRYRVQPXXXXXXX XXXXXXXXXXXXXXXXXXXXXX-X--
XXXXXXXXXXXXXXXXXXXXXXXX-X--XX YFMGRNDGGLLTIDSKTAQIKFIRNIDRDS
TFIVNKTITAEVLA--IDE---TT-GKTSTGTIYVKVPNFNENCP-AVFLEKKTACS---
P-SPSVVVSIRTLDGDKYSGPYTFSLEQQPLKLP-VMWSVTSLNA--TSAL--LRAQQQL
SPGVYRISLMYTDSQGRQCETPESLILD--VCQCDDRDACRATSDTNR------------
------------------------------------------------------------
-----------------------------DP----TKNYGKRPSGRLGPNAIGLLILGLL
----LLLXXXXXXXXX--------------------XXXXXXXXXX-----XXXXXXXXX
XX-------XXXXXX---X-XXXXXXXXXXE------ITNICVP-PIT------------
-------------------------------ANGTDF-MESSEVC--------TNTYAGG
T-V--MEGA---S--GMELTTKVGASTGSGAAAGFAAGTASGAAGGFGGNACVTCSAAGQ
S--CTMRTRHS-TG-TNKDHVEG-S-------IS-MTFLDTYFA----------Q---KA
SACAEEEEVRDTNDCL---LIYDDE--G----ADIPRPPIDSLSCCSLLPEDDIDDHFLD
S-----LGPKFKKLAEITLGLDD-ESKQAQSS---AKDSGSGVDSCGL----AVKVP---
------------------------------------------------------------
-------LSGSAQCQTLSGRQGASAVH-ASVC-VQPAIPI-PDPLQH-GSYLLTETYST-
SGS-LRQ---PSTMVFDPLLTQNVTVTERVICPVTNVS---SNLTCPV------EIRGSR
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHFFR--TA------AVLFICLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-AAECECSIKI L-DVNDNIPYMEQST YA--IE-IKENTLNSDLLQI---RV
IDLDEEYSANWMAVIFFISGNEGGWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEDVK
NLQLSIGVRNKAEFHHSV-MSQYKLTATAISVTVLNVVEGSVFRPGSKTYVVTSD-----
MGQNYKVGDFIATDLDTGLASTT---V--RYVMGTNPADLLAVNSETGIITLKNKVTREQ
YDMLNGKYQGTILS--IDD---AL-QRTCTGTIIIDLQGNGWEGG---------------
-----------------------------------------GRDT--G------------
-----------------------------------------------------TSTKETP
GPDIVI--------NTET------------------------PGNG-PNTLVGGP-----
----------------D----------------SFPDRGLLSDNVHFGPAGIGLLIMGFL
----ILG--LVPFLLL--------------------CCDYGGA---SG--GGAGFEPVPE
CT-------DGAIHS---W-AVEGPQPKPGD-----FA-TVCVPQIP----PD-------
------------N-------------------ANLIEYIDTSGVY--------TNEYGGR
EMQ-DLGGGERTT--GLEVTDGVKTPGVP------------------------ETCQ-EY
S--GTLRR------NSMREGREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEV-ESYPDPDP---SWPPERTEPVCPQPGT--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPVPI-PDPLGY-GNVTVTESYTTS
-G--TLR---PSVHVHDNRHASNVVVTERVVGPISGAD-FHGML------DMPDLTDGS-
NIIVT--------------------------ERVIAPSSSLPTTLTI-PDPRESSNVVVT
--ERVIRPTSGMMGS-LSMHPELSNAQNVIVTERVVSG-SGITGIS--------------
----------SGLVG------------------------------SGA--GISGGGMGLS
SLGGGGGLSS-------SIGGTATIGHMRSSSDHHFSQT-----LGSTSPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLLFR---NF-----CLLIILMVVL--E
VN--SE-FVVEVKEL-DAENGTAK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIVSQEPAGSPMFIMNRYTGEVCTTSNLLDRE----QHSMYNLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRF---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VI-----------------
---------------------------------------------------KTLDYEQVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQ VVNVREGPAFQPNSMTFSVREGL-KGN
SLLNF VLGTYTAIDLDTGNPATNV-----RYIIGHDAGNWLKIDSRTGEIQFSREFDKKS
KYITNGIYTAEILA--IDD---GS-LKTATGTICIEVPDVNDYCP-VIVAERETICI---
A-SPSILISAAGVNSHPYGSPFTFCVVNEPPGTA-DIWDITSVNA--TSAI--LKAEQTL
YSAYYEIPILVKDSFNRACELPQIIELR--ACDCDINHVCLYSGITDVSTGDGSSVTS--
------------------------------------------------------------
----------------------VS----------VTDDQTEASNVGMGSTGIGMITMGVL
----LLL--LAPLLLL--------------------LCCCCKRKQPEG--LGTSFAPVPE
GG-------EGVVQS---W-RIEGAHPEDRD------VSNICVPM--T--A---------
--------------------------------SNTQDRMDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--AAAGLAAGG------------------------A
A--GTAGRRSS-AVGIQRDYGDT-S-------LN-LAFLDSYFS----------E---KA
YAYAGEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESHME
T-----LDPKFKTLAEICLNTEI-DPFPS-QQ---SCIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFKEEMAI-PEPMMH-GDIVVTETYTTA
--DPCMQ---PTTIVFDPQLAPNVVVTETVMAPVYEVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVIYAERVVSS-PGRPDVSSSSMSDG-------
--------CRGPVMSGG---------------------------------ILVGPEIQLT
Q---------MM-----------------S-PDIRISQT-----IGSTSPVT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
--------------------------------------------------------VVLE
VN--SE-FIVEVKEL-DIENGTTK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCEANQ--RITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPFLXXX
XQIMSALNRGEDLERP-ELRVKV MDINDNPPVFTQHV YTASVEENSDANVMVVKVSATDA
DEDNHLNSKIAYKIVSQEPAGAPMFILNRYSGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKI L-DVNDNFPILEKTS YS--AS-IEENCLSSELMRL----A
IDLDEEGXXXXXXXXXXXXGNDEKWFDIQTDPQTNEGIVK-VV-----------------
---------------------------------------------------KMLDYEQVP
NIHLSIGVKNQAEFHHSV-ASQFRMHSTPVRIQV INVREGPTFDPSI MTFSVREGI-KGD
SLLNYVLGTYTATDLDTGNPATNV-----RYILGHDASKV----NKTGEIQFR-EFD-KS
KYITDGIYTAEILA--VDD---GS-GRTATGTICIEVPDINDYCP-VIFSEK-NTCI---
A-SPSIFIFV---EDHSYGAPFTFCVVDQPPGTE-YIWDIRSINA--TSAY--LMTDQTL
SPGPYQVPVLVKDSYNRACELPQMVQFY--ACDCENNQVCSSSGTTGIYTEDF------T
------------------------------------------------------------
---------------SVTTDIYGP----------ATDDQVGVSNVGLGPAGIGMIVMGIL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVMRS---W-GIEGAHPEDRL------CRTAPGRGGAG--SWRA------
--V----DGQPKQ------------------IAPALEHPLFSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGLG--TATGLVAGG------------------------A
V--GAARKRSS-TMGTLREYADT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAA-SEPVLH-GDIIVTETYTTD
--DQCIQ---PTTIVFDPQLPPNVVVTETVMAPVYDLQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNIIYTERVLPS-PGMPDMNNSCMTDS-------
--------CMGPMMSGS---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDVHISQA-----IGSTSPMA-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------------------------------ICF--T
FG---SGLHLEFFNT-RRESKLLPG-HT-----HLVRQKRSWITAPGNLWEGEDLTKKNP
IAKIHSDIAE-SGVKVTYKYTGTGITEPPFGIFVFNKDTGELNITRI-LDREETPFFLLT
GYAMDS--KGSNLEKPLELRIKVLDINDNKPVFTQEVFTD---------TLVMKITATDA
DEPNTINSKISYRIVSQEPPYPVVFHLNTDTGEIFTTS-ALDRE----EHSSYSLTVEAK
DGYGQVTDHPVHQAQVQIR IL-DVNDNIPVVANGLLE--GT-IKENQVNVEVTRI---KV
IDADEVGSDNWLANFTFVSGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMK
NLDFNVIVTNKAAFHKSI-INKYKPTP IPIKVKVTNVKEGISFKSSTISVHARE--GMDI
SSQ SQSIGKFQVFDEDTGQSA-NV-----KYVKVEDRDNWVSVDSVTSEIRLVKIPDFES
RYVQNGTYTVKIIA--VSQ--G---KKTITGTVLIRVEDINDNCP-TLVNPVQSVCK---
D-APYVNVTAQDLDGYPNSWPFSFSVIDTPPGTA-AKWKIIHQES--TSVL---LQQDEH
KLGRSKIPFLITDNQGLSCLEKQVLELT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------QRTSYVGLGPAAIALIILALL
----LLL--LVPFLLL--------------------LCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPAILAV-----DHAENATVRNE
VG-----SAMANEGT-MKG---------SSSTSFFKVQQDQTNMD--GRWEEHRSLLGNG
ATQ--VTGTTGAR-LGAKTSWIRGT----L-----GASRE---------MA---------
-G----AHT------------------AAAGVVS-EEFLRNYFT----------D---KV
ASYTEEDDIHMAKDCL---LVYSQEE-T--------ASLHGSIGCCSFIE-GELDDRYLD
D-----LGLKFKTLAEVCLGRKI-DVDMEVEQR--QKLVKE----------TNL-STAAH
SLYEQTTVNS-------------------KNTYS--G-GSLP-----------------V
PKP--LQE---ASAEMVTQEVVTERSV-SSRQGHKVTPPP-PDPLASDNI-IVTETSYTT
-GSTVS----PSTVILAPRQPQNLIVTERVYAPASTLV-------------DQH-YAGEG
NVVVT--------------------------ERVIQPKGTIPHPLQGSQHLHDAQYVMVT
EKESVLAPGYGGQPT-LAMPNV---GQNVTVTERVL------------------------
-------TPASALDSRYQI---ASEASGKAGT-----A-----VISGA--GVPGPLPHS-
--------------------GLEGSGHSNS-------------------TITTSSTRVTK
HSTVQHSYT----------------

------------------------------------------------------------
------------------------------------------------------ICL--D
FG---HGLHLEILNT-RSGNKLSPK-HT------LVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEERGLKITYRYTGKGITEPPFGIFVFNKDTGDLNVTRI-LDREETPFFLLT
GYALDV--KGNNLEKPLDLRIKVLDINDNEPVFTQEVFVGSVEELSVAHTLVMKITATDA
DEPNTMNSKISYRIVSQEPAYPPVFHLNKDTGEIYTTSITLDRE----EHSSYSLTVEAK
DGNREITDKPVAQAQVQIRIL-DVNDNIPVVENGMVT--HF-FIITVP------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWHFFR--TA------AVLFIFLXXX--X
XX--XXXXXXXXXXX-XXXXXX-X-XXX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXIHSDCAANQ--QVTYRISGVGIDQPPFGIFIINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLERPLELRVRV LDINDNPPVFSMST FIGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQDPSDSPMFIINRYTGEIRTMNNFIDRE----SCGQYSLAVRGS
DRDGGADGM-SAECECNIKV L-DVNDNIPYLEQPS YT--IS-FQENSLYSNLMEM---RV
IDLDEEFSDNWIAVIFFISGNEGNWFEIEMNERTNVGIFK-VV-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSIGVRNKAEFHQSI-LSQYKLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----
XXXXXXXXXXXXXXXDTGRASTS-----VKYVMGNNPADLLAIDSKTGIITLRNQVTYEQ
VQMLGGRYQGTILA--IDX---XXXXXXXXXXXXXXXXXXXXXXX---------------
-----------------------------------------XXXX--X------------
-----------------------------------------------------XXXXXX-
--------------XXXXXXXXX---------------------X--XXXXXXXX---X-
--------X-----------X------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
----XXXXXXVPFLLI--------------------CCDCGGA---SG--GGAGFEPVPE
CS-------DGAIQS---W-AVEGPQPELRD------LTTICVPQIP----SD-------
------------N-------------------ANMIECIDTSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELEEGVKT--AP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEV-EPCPFPDP---SWPPESNEPICPQA-T--------D
PL------------------------------------------------SSG---HPPI
SPQ----------FG--TTTVISESTY-PSGPTIHHPMPI-PDPLSY-GNVTVTESYTTS
-G--TLK---PTVHIHDNRQASNVLVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSGLPTSFTI-QDPRDSSNVVVT
--ERIIRPTSGMMGN-LSMNPDLSNAQNVIVTERVLSG-SGIAGISGPVGLST-------
---------GSGTVSSGL-----IGTSGGLSG----------AG---I--GTTGGGMGLS
-----------------SMGGTATIGHMRSSSDHHFSQA-----LGSASPST-ARSRVTK
YSTVQYTKQ----------------

------------------------------------------------------------
------------------------------MDWRF--FRVA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF VGQIEENSNANTLVMVLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YA--IS-IEENTLNSNMLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-IV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNKAEFHHSI-MSQYKLTATAISVTVLNVIEGPVFRPGSKTYVVTGN-----
MGSNDKVGDFVATDLDTGKPSTT---VR--YVMGNNPADLLAVDSRTGKITLKNKVTKEQ
YNMLGGKYQGTILS--IDD---AL-QRTCTGTININIQNVNGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQANTEV
---------------TNTGREES----------T-------------SSTDYETSTTYAS
SQ------------------G-----G-ASTNHNGESIPLFSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPGV-----MT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDPDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---FWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHFHDNRQASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPASLTI-HHPRESSNVVVT
--ERVIQPTSG-LGS-LSMHPELTNAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MSWLSL---RII-----GTLVILMVVI--L
VH--GE-LRIQTNGQ-YGEDEKVVQ-QA------KRRYKREWVKFAKPCRETEDNSKRNP
IAKITSDFQATQ--KITYRISGVGIDKPPLGIFVVDQNTGDINITAI-VDREETPSFLIT
CRALNY--LGQDVEKPLMLTVKI LDVNDNAPVFSQSI FSGEIEENSPSNSLVMVLNATDA
DEPNSLNSKIAFKIVSQEPXXXXXXXXXXXXXXXXXXXXXXDRE----QVSSYHLIVSGA
DRDGDG--L-AAQCECNIKV K-DVNDNFPVLKESQ YS--AH-IEENTLSSELLRF---QV
TDWDEEFTDNWRAVYFFTLGNEGKWFEIETDSRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVQFSIAVKNKAEFHKSI-ISQYRVQSTPVTIQV VNVREGLIFRPAS KNFTVHEGT-SSK
KLVNYVLGTYQAIDEDTGKAASQV-----RYVMGRNNGGFLTVDSKTAEIRFIKNIDRDS
TFIVNKTITAEILA--IDE---NT-GKTSTGTVYVEVPGFNENCP-TITLEKRTICI---
S-SPTVVVSATALANNKYNGPYTFSLEEQPSKLP-AMWSITTLNA--TSAL--LRAQQQV
PPGVYRISLTVTDRENKKCDTPESFTLE--VCQCENRDVCARFDPNRGS-----------
------------------------------------------------------------
-----------------------------TP------SYGQPSSVWLGPAAIGLIILSLL
----LLL--LIPLLLL--------------------TCDCGM-GRAGG--VPGGFIPVPD
GS-------EGTIHH---W-QIEGAKPQDKE------ITNICVP-PVT------------
-------------------------------GNGVEF-MENSEVC--------TNTYAAG
T-V--ADGA---S--GTELTTKLGASAGSGAAGGFATGTV----CEAAGASGFGTCSGGH
S--GTMRTRHS-TGGTNRDHAEG-S-------VN-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----MEAPDSPVGSVGCCSFIA-EELDDSFLD
S-----LGPKFKKLAEISLGVDE-EAKQSQLL---IKEGSFGIDSCGR----S-EGQQP-
------------------------------------------------------------
---------EPIRCQTLQGSQGASALS-ASASVLQSAISI-PGPLQH-SNYLVTETYSA-
SGS-FMQ---PSTAVFDPLLTQNVTVTERVICPIASVP---GNLQGPS------EL-GSR
NTICT--------------------------ED-----------PC--------------
--SRLL------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------EWGSKGNRC-----------KLFPVCL--D
FG---NGLHLEVFST-RRGDKLLPK-HS-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDKNTGNLNITSI-LDREETPFFLLT
GYAMDS--RGNQLEKPLELRIKVLDINDNEPVFKQEVFVGSVEELSAAHTLVMKVIATDA
DEPNTLNSKISYRIVSQEPANSPMFYLNKDTGEIYTASFTLDRE----EYSSYSLTVEAR
DGNGQITDKPVQQAQVQIQI L-DVNDNIPVVENKV YE--GV-VEENRVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMR
NLNFSVFVTNKAPFHKSV-QNKFKPTPIPITVKVKNMVEGIHFKNSVVSVRASE--AMDR
SSLTRSIGKFQVFDEDTGQAATKV-----KYAKVEDIDNWISVDSVTSEIKLVKIPDFES
GYVQNGTYTVKVVA--ISS--DHP-QKTITGTVLISVEDINDNCP-TLVEPIQRICE---
D-APYVNVTAKDLDGPQNSGPFSFSIVDQTPGTA-ENWKIIRQES--TSVL---LQQRER
KLGRSEVPFLISDTQGFSCPEKQVLQLT--VCECLGGGGCAEA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLGPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVT-----DHAGNSAARNG
VG-----GAVLKESM-AKG---------SSSASFTKGQHELSDVD--GRWEEHRSLLTTE
TTH--LVGTAGAI-AANETLRRARA----T-----GASRD---------AG---------
-G----AR-------------------GAAVAMN-EEFLRSYFM----------E---KA
ASYAEEDDIHTAKDCL---LVYSQED-T--------DSLRGSIGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGRKI-SLDVDVEQK--QKPVRE----------ASV-NLASG
SHYGQTMVNS-------------------ESTYA--SDSGFQ-----------------L
P------K---AHSEKVTQEIVTESSV-SSRQSQKVVPPH-PAPVASGNI-IVTETSYSA
-GSAVP----PSTVTLGPRQPQSLIVTERVYAPASTLV-------------DQH-YGNEE
NVIVT--------------------------ERVVQPNGGIPKPLEVSQHLKDSQYVMVR
ERESILAPSSGAQPT-LVMPSV-AAGQSVTVTERVL------------------------
-------APASSLPSGHHP---PSETSMKARK-----T-----TVSSV--GGLGPLPNL-
--------------------ELEESGHPSS-------------------TVTTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------------------------------VLI--L
VH--GE-LRIETKGQ-HGEDDIAV--QG------KRRYKREWVKFAKPCREREDNSKKNP
IAKITSDFQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CHALNA--LGQDVEKPLILTVKI LDVNDNPPVFSQSI FMGEIEENSASNSLVMILNATDA
DEPNHMNSKIAFKIVSQEPAGTPMFLLSRHTGEVRTLTSSLDRE----QVSSYHLIVSGA
DKDGEG--L-STQCECSIKV K-DVNDNFPMFRESQ YS--AR-IEENTLNSELLRF---QV
IDWDEEFTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
NVQLGIAVKNKAEFHQSV-ISQYRVQSTPVMIQV VNVKEGIAFRPASKR FTVQKGI-SSK
KLVNYVLGTYQAIDEDTAKAASYV-----KYMMGRNDGGLLFIDSKTAQIKFVKNIDRDS
TFIVNKTITAEVLA--IDE---NT-GKTAKGTIYVEVPSFNENCP-TIVLEKKTICS---
S-QPSVVVSARA-LDNKFTGPYTFSLEEQPLKLP-VVWGITTLNA--TSAL--LNAQQPL
SPGTHSISLTVTDSQDRQCETPESLTLE--VCQCDNRDTCRTPNGNKDP-----------
------------------------------------------------------------
-----------------------------ER------IGGKTSSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GPIGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNIRVP-PIT------------
-------------------------------ANGADF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTKLGTATGSGDAAG------------FGAATGLGIGSARQ
S--GTMRTRHS-TGGTNKDYGEG-A-------AN-MNFLDSYFS----------Q---KA
FACAEEDDAQEANDCL---LIYDNE--G----MGAPSSPVGSLGCCSFIA-DELDDSFLD
S-----LGPKFKKLAEISLGIDD-ETKQSQPP---SKDSHFGIESCGY----SLGVQQS-
------------------------------------------------------------
---------ESVRGQTLSGHQGASALS-ASGSALQPAISI-PDPLQH-GSYMVTETYSA-
SGS-LVQ---PSTTVSEPLLTQNVIVTERVICPISNVP---GNLQTPM------ELRGSR
NMICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWQPFT---A------AALLLCLVMV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPYFIIV
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTFI GQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDAPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECECSIKI L-DVNDNIPYLEQSS YE--LK-IEENALYSDLLQL---RV
IDLDEEYTANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------QPLDYEAVK
NVQLSIGVRNKAEFHHSI-MSQYKVVGTAISVVVSNVIEGAVFRPGSKTYVVTSN-----
MGANHKVGDFVATDLDTGSASTT-----VRYVMGNNPADLLAVDSKTGTLTLRKQVTMEQ
YKMLRGRYEGTLLS--IDD---SL-HRTCTGTIVIDLEGSGWSTA---------------
-----------------------------------------EGGG--T------------
-----------------------------------------------------ETENQGG
TSTSTD---TSTGTIPRTDESDA-GDTTSTTGEGVSTNENDNSGGT-DYGEGG-------
--------N------TQNTQQ-----GGGGAGGGGVEKESSADNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDYGGP---AG--GSAGFEPVPE
CS-------DGAIHP---W-AVEGPQPEPH------DMATICVPQIP----PG-------
------------G-------------------ATMMECIDNSGVY--------TNDYCAR
EMQ-DLGGGERTT--GFELMEGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMENYFC----------Q---KA
YAYADEEEGRPSNDCL---LVYDIEG-A--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKET-ECYPDPDP---SWPPRNTEPIYPPQTT--------G
PI------------------------------------------------PSG---LASV
SQQ----------VG--TTTVISESTY-PSGPGVHHPMPI-PDPLGY-GNVTVTESYTTS
-G--SLK---PAVHLHDNLHAPNVVVTERVVGPISGAD-FHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-PTPIESSNVVVT
--ERVIQPTSGMIGS-LGRHPDLSNAHNVIVTERVVSG-AGMGGISGAAGISG-------
-----------GVGSSGL-----VGTNMGVSG----------SGLSGP--GISGGGIGMG
GLGGGGGLSG-------NVGGTATISHMRNSSDHHFTQT-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--VA------AVLFIFLWNL--N
YK--FK--LIYVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--VE-IQENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
SLQLSIGVRNKAEFHHSI-MSQYKLTASAISVTVSNVIEGPVFRPGSKTYVVTGN-----
MGANDKVGEFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTREQ
YNMLGGKYQGTILS--IDD---TL-QRTCTGTINIDIQGFDGDDR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TEPSTEI
T--------------TNTGRQES----------S-------------SSTDYETSTTSAV
SQ------------------Y-----IVSYGPA---NESPLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---SR--GAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----MT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGMP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HLPI
SPH----------FG--TTTVISESTY-PSGPGIQHPKPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHVHDNRPASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIS--------
--------G--GIGSSGL-----VGTSMGAGG----------GALSGA--GVSGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPSA-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MNWRSLL--TA------AVLFIFLXXX--X
XX--XXXXXXXXXXX-XXXXXX-X-XXX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXIHSDCAANQ--QVTYRISGVGIDQPPYGIFIXXXXXXXXXXXXX-XXXXXXXXXXIY
CRALNS--QGQDLERPLELRVRVLDINDNPPVFSMTTFIGQVEENSNAXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YA--IK-IEENALYPDLLQI---RV
IDLDEEYTANWVAVIFFISGNEGNWFDIEMNERTNVGTLK-VI-----------------
---------------------------------------------------KXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXX-----
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYVMGNNPADLLSVDSRTGVITLRNRVTMEQ
YQMLRGKYQGTILS--IDD---SL-QRTCTGTVIINLEGSGWETR---------------
-----------------------------------------ETNT--E------------
-----------------------------------------------------RRIRTNA
G-----------------------------------------------------------
----------------------------TETSGVETNTNDLSDNVHFGPAGIGLLVMGFL
----ILG--LVPFLLL--------------------CCDCGGT---SG--GGAGFEPVPE
CS-------DGAIHA---W-AVEGPQPQPTD------LGTISVPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNDIGGR
EMH-DLGGGERTT--GWELMDGVRSSGAA------------------------DISQ-EY
P--GTLR-------SPMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKET-ESYPDPDP---SWPPQSTEPMFPQQGT--------E
PV------------------------------------------------VNG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-SDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNRHASNVVVTERVVGPISGAD-LHGML------EMPDLREGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-SNPRESSNVVVT
--ERVIQPTSGMMGS-LSMHPELANAHNVIVTERVVSG-AGLSGISGTTGMS--------
--------GGGSVGSSGF-----VASTMAAGG----------GTMGGT--GINGSGIGLS
-----------------SMGGSATIGHMRS-SDHHFSQT-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWLFFR---NI-----YLLIILMVVM--E
VN--SE-FIVEVKEF-DIENGTAK-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IAKIRSDCESNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNAPVFSQSV YTASIEENSDANALVVKLCATDA
DEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVRTMSSFLDRE----QHSMYNLVVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPTLEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQAP
NIQLSIGVKNQADFHYSV-ASQFRMHPTPVRIQ VVNVREGLAFHPSTMAFSVREGI-KGS
SLLN YVLGTYTAIDLDTGNPATDV-----RYIIGHDAGSWLKIDSRTGEIQLSREFDKKS
KYIINGIYTAEILA--IDD---GS-GKTATGTICIEVPDIHDYCP-NIFPERRTICI---
D-SPSILISV---NEHSYGSPFTFCVVDEPPGTA-DMWDVRSTNA--TSAI--LTAKQVL
SPGFYEIPILVKDSYNRACELAQMVQLY--ACDCDDNHMCLDSGAAGIYTEDI-------
------------------------------------------------------------
-----------------TGDTYGP----------VTEDQAGVSNVGLGPAGIGMMVLGIL
----LLL---LSPLLL--------------------LLCCCKQRQPEG--LGTRFAPVPE
GG-------EGVMQS---W-RIEGAHPEDRL------FSAYALPGGGG--TADG-GGDSV
LGR----CALQAT------------------RALLHQHPPFSEIY--------TNTYAAG
GTV--EGGV---S--GVELNTGMG--TAVGLVAAG----AAGAA--------------GA
A--GAARKRSS-TMGTLRDYADS-D-------IN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESCME
T-----LDPKFRTLAEICLNTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGLT-PSEVEFQEEMAA-SEPVVH-GDIIVTETYGNA
--DQGVQ---PTTIIFDPQLAPNVVVTEAVMAPVYDIQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELADYNNVIYAERVLAS-PGVPDMSNSSMTDG-------
--------CMGPVMSGN---------------------------------ILVGPEIQVM
Q---------MM-----------------S-PDLPISQT-----VGSTSPMT-SRHRVTR
YSNIHYTQQ----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--QITSDFQATQ--RITYRISGVGIDQPPFGIFVVDPNTGDINITAI-VDREVTPSFLIT
CRALNA--LGQDVEKPLILTVRILDVNDNPPVFSQTIFMGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPGGMPMFLISRNTGEVRTLTSSLDRE----QVSSYHLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMLTDSQ YS--AN-IQENTLNAELLRF---KV
TDWDEEYTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQAQ
RMQFSIAVRNKAEFHQSI-ISKYQVQSTPVTIQ VINVKEGISFRPTSKTFTVQKGI-SGK
KL IGYTLGAYQAIDEETGKAATSV-----RYVMGRNNGGLLIIDPKTAEIKFVKNIDRDS
TFIVNRTITAEVLA--IDE---NT-GKTSTGTVYVEVPSYNENCP-SVVLEKQEICS---
S-LPSVTVSARTLDRSKYSGPYTFSLEEQPVKLP-AIWSITTLND--TSAL--LRAQQQI
SPGVYTVPLVITDNQNRQCEMPESLTLT--VCQCDERGACGKADPSREL-----------
------------------------------------------------------------
---------------------------------------RNPSTWRLGPAAIGLILLGLL
----MLL--LAPLLLL--------------------TCDCGT-GPIGG--ATGGFVPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------MTNICVP-PIT------------
-------------------------------TNGADF-IESSDIC--------TNTYAGG
T-V--MEGA---S--GMELTTKLGAATGSGTTGGF------------GEASGLGPCPLGM
S--GTMRTRRS-TGGTMKDYADG-S-------IN-MNFLDSYFS----------R---KA
FACAEEEDIQEASDCL---LIYDNEG-L----DDAPGSPVGSLGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGIDD-EAKQAPLP---SKDSGSGVDRCGR----PLDVQQSG
ADRCQTLPGDV-------------------------------------------------
------QQSGADRCQTLPGSQRASALS-VSGS-VQPVIAI-PDPLLH-GNYMVSETYSV-
SGS-YVQ---PTTAVFDPLSTQNVRVTERVVCPISSV---------PT------ELRGSH
TMLYS--------------------------EE-----------PC--------------
--SHL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MAWLLP---RNT-----GALAILMAFV--L
VH--GE-LRLEXXXX-XXXXXXXXX-XX------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXITSDFQATQ--KITYRISGVGIDQPPFGIFAVDPNTGDINITAI-VDREETPSFLIM
CRALNA--LGQDVEKPLILTVKI LDVNDNYPVFSQNI FTGEIEENSASNSLVMKLNATDA
DEPGHLNSKIAYKIVSQEPAGIPMFLISRNTGEVRTLTNSLDRE----QVSSYRLVVSGA
DKDGDG--L-STECECSIKV K-DVNDNFPTLRASQ YS--AS-IKENTLSSELLRF---EV
TDLDEKFTDNWLAVYFFTSGNEGNWFEIETDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQMQ
NMQFSIGVRNKAEFHQSV-ISQYRVQPIPVTIRI IDVKEGIAFRPASKTFT VQKSI-SST
KLINYVLGRYEAIDEDTGKAASSV-----RYIMGRNDGGLLAIDLKTAQIKFVKNINRDS
TFIVNKTITAEVLA--IDE---NT-GRTCTGTVFVEV PSFNENCP-TIVL ENTTICS---
S-SPVVVVSARTLERDKYAGPYRFSLEDHSLKLPPGTWSITTLNA--TSAQ--LRARQPV
TPGEYRVPLVLTDREGRQCEMPESLTLE--VCQCDDRGFCGKTGPIREP-----------
------------------------------------------------------------
-----------------------------TR---------RQPSWSLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGT-SALGG--GTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGAEF-MESSEVC--------TNTYAGG
T-V--VEGA---S--GMELATKFGTAAASGAAAGFGA------------AGGL--GSTGQ
S--GTMRTRHS-TGGTSRDYADG-T-------IS-MNFLDSYFS----------Q---XX
XXXXXXXXXXXXXXXX---XXXXXX--X----XXXXXXXXXXXXXXXXXX-XXXXDSFLD
S-----LGPKFKKLVEISLGMDE-EVQQAQWP---STDSSAGIGSWGQPKIYSHQAQRA-
------------------------------------------------------------
---------DFVRCQTLSGGPGGLVLS-ASGS-FQPAIPI-PDPLQQ-ANYLVRETYSAS
ASSTLMQ---PSSAVFDPLLTPNVIVTERIISPMASTA---GNLLIPT------ELRGTC
SGPCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LT
GYALDS--KGNNVEKPLNLNLKVLDINDNEPVFTXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX--XX-XXXXXXXXXXXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XGVDYEKVK
NLDFVIAVTNKAAFHKSI-RSTFRPTAIPIKVKVKNVKEGIYFKSDTIHVQVSE--GMDT
TSQSRTLGKFPVFDEDTGQQA-RV-----TYVKFEDMDNWVSVDSASSEIKLVKSPDFES
RYVQNGVYVVKVLA--VSE--DFP-RKTITGTVSIMVEDTNDNCP-TLVEPVQTVCD---
Y-VEFVNVTAVDLDGHLNSDPFTFSIVDTPPGMA-ERWRIAQQAS--TSVL---LQQTEK
QVGRSEIQFLISDSKGLSCSEKQVLQLT--VCQCQHGLGCAEK-----------------
------------------------------------------------------------
---------------------------------------RSDAYVGLGPAAVALLILALL
----LLL--LVPLMLL--------------------MCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLAV-----DHGENLAVRNG
VG-----GMVTKEAT-MKG---------SSSASFTKGQHDMSEVD--TRWEEHRSLLSAA
PAQ--VTGAAGAS-LGTETVRTLRA----T-----GSSRD---------LA---------
-G----AR-------------------AAAVALN-EDFLKSYFT----------E---KA
ASYTDEDDVRLAKDCL---LVYSQEE-T--------SSLHGSIGCCSFIE-GEFDDRFLD
D-----LGLKFKTLAEVCLGQKI-GIETETEQR--QKPVAD----------TRV-NTASY
PLYEQAAVSS-------------------ETAHS--SGSSSA------------------
-----VRE---AHAETVTQEIVTERSV-SSRQGQRAVPPR-TDPLASSNI-IVTETSYAT
-GATVP----PSTVILAPRQPQSLVVTERVYAPAASLV-------------DQH-FANDG
SVTVT--------------------------ERVIQPGGGIPKPLDGPQHLQD--YVMVQ
ERESILAPKSGVQPT-LAVP----VGQNVTVTERVL------------------------
-------AP-ASLPSSYPV---PSAASVMTQR-----T-----TGSAA--RGPGPLPNA-
--------------------GLEESGHSSS-------------------TMTTSSTRVTK
RSTVRQSYS----------------

------------------------------------------------------------
-------------------------MKLVKKYKTYLKFCTI------FELQNVRGDV--V
IE---GNLVKQVFSA-RRGDKLPPK-HT-----HLVRQKRAWITAPVALREGEDLSRKNP
IAKIHSDLAEEQGIKITYKYTGKGITQPPFGIFVFDKNTGDLNITSI-LDREETPYFLLT
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFAQDVFAGSVEELSAAHTLVMKIVATDA
DEPNTLNSKISYRIVSQEPANSPMFYLNKDTGEIYTSSFTLDRE----EYSSYSLTVEAR
DADGQITDKPVQQAQVQIR IL-DVNDNIPVVENKM YE--GV-VEENQANVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYEKMK
SLNLSILVTNKAAFHKSV-RNKFKATPIPIT VKVKNVVEGIHFKSSVVSVRASE--AMDR
S SLSRSIGKFQVFDEDTGQAA-KV-----KYAKVEDIDNWVSVDSTTSEIKLVKIPDFES
RYVQNGTYTVKVVA--ISS--DHP-QKTITGTVIITVEDVNDNCP-TLVEPVQRICD---
D-APYVNVTAEDLDGPQNSGPFRFSIIDQPSGTA-EKWKIIHQES--TSVL---LQQSEQ
KPGRSEIPFLISDSQGFSCPERQVLQLT--VCACLRGGGCAEA-----------------
------------------------------------------------------------
---------------------------------------QYDNYVGLAPAAIALMILALL
----LLL--LVPLLLL--------------------ICHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLVA-----DHAENSAVRNG
AG--GAGGSMLKESL-VKG---------SSSASFTKGQHELSEVD--ARWEEHRSLLTGG
ATH--LVGTAGAI-AANETLRMTRA----T-----GASRD---------MS---------
-G----AR-------------------GAAVAMN-EEFLRSYYI----------E---KA
ASYAEEDDLHMAKDCL---LVYSQEE-T--------DSLRGSVGCCSFIE-GELDDLFLD
D-----LGLKFKTLAEVCLGRKI-NLDVEGEQR--QKPVGE----------ASV-NPAAG
SLYEQTMVNS-------------------ESSFS--SGCGFQ-----------------V
PKP--LHE---AHAEKVTQEIVTESSV-SSRQSQKVVPPP-PDPVASGNI-IVTETSYAT
-GSTVP----PSTVILGPRQPQSLIVTERVYAPASTLV-------------DQH-YANEE
NVLVT--------------------------ERVIQPNGGVPKPLEVTQHLKDSQYVMVR
ERESILAPSSGVQPT-LVMPSV-AAGQNVTVTERVL------------------------
-------APASSLQSGYQI---PSETSLKARK-----T-----VLSSV--GGLGPGPSL-
--------------------GLEESGHPNS-------------------TVTTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
-----------------------------------------MARGAEGALLLLLICF--N
FG---NGLHLEALHS-RNENKLLPK-HT-----HLVRQKRAWITAPVSLREGEDLSRKNP
IAKIHSDLAEEKGIKITYKYTGKGITEPPFGLFVFNKDTGELNITSI-LDREETPFFLLI
GYAVDE--KGNNLEKPIELRIKVLDINDNEPVFTQDVFVGSIEELSAANTLVMKITATDA
DEPNTLNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSITLDRE----EYSSYTLTVEAR
DGNGQITDKPVKQAQVQIR IL-DVNDNIPVIENKV YE--GT-VEENQANVEVLRI---KV
FDADEVGSDNWLANFTFASGNERGYFHIETDTQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYEEMK
SLNFSVIVTNKAAFHKSV-KNKYKPTSIPIR VKVKNVKEGIYFKSSTVRFHASE--S MEK
SSQSQILGKFQAFDEDTGQVA-RV-----KYAKLEDIDNWIYVDSATSEIKLVKIPDYES
RYVQNGTYTVKIVA--VTE--EYP-RKTITGTIVIMVEDVNDNCP-TLVEPVQMICD---
D-AKYVNVTAVDLDGPQNSAPFSFSIIDKPAGMA-ERWKIVHQES--TSVL---LQQNEQ
KAGRNQIRFSISDSQGFSCPEKQILDLT--VCKCVEGRSCAERRS---------------
------------------------------------------------------------
---------------------------------------WSDSYVGLGPAAIALIILALL
----LLL--LVPLLLL--------------------TCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VVPLLGA-----DHRDGVAAGGG
VA-----GMMSKEAT-VKG---------SSSASFTKGQHELSEMD--SRWEEHRSLLSGG
ATQ--VTGTTGAV-VSTETMRTTRA----T-----GASRE---------MA---------
-G----AQ-------------------AAAVAVN-EEFLRTYFT----------E---KV
ASYTEEDDIHIAKDCL---LVYSQEE-T--------ESLQGSIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-EMDAEMEQR--PKAVRE----------TSG-QAPSG
SLYEQTRVNS-------------------ENAYS--SGSSFQ-----------------V
PKP--LPE---VNTEKLTQEIITEKSV-SSRQGQTIAAPL-SDPLASGNM-IVTETSYAT
-GSTLP----PSTVILGPNQSQGLIVTERVYAPASSLL-------------DQQ-YASEG
HVVVT--------------------------ERVIQPDGGTSGPLEGPGHLPDAHYVMVR
ERERFLTPSSSLQPP-MAVPSV-AIGQNMTVTERVL------------------------
-------SPASTLQSSYQI---PTETSVTTKK-----T-----VVSGT--RVPGPLPNL-
--------------------GFEEPGHSNH-------------------TITASSTKVTK
HSTIQHAYS----------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTMQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGINQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRDSQ YS--AS-IEENILSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGI-SSK
KLVDYILGTYQAIDEDTNKAASNV-----KYVMGRNDGGYLMIDSKTAEIKFVKNMNRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPDFNDNCP-TAVLEKDAVCS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGICGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PVT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGH----PIEAQQT-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MMGLFP---RTT-----GALAILMVVV--L
VH--GE-LHIETKRQ-QEEDRTAVQ-HS------KRRYKREWVKFAKPCREREDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGEINITAI-VDREETPSFLIT
CRALNA--LGQDVEKPLILTVKI LDVNDNPPVFSQSVFM GEIEENSAVNTLVMIINATDA
DEPNHINSKIAFRILSQEPAGTPMFLLSRNTGEIRTLTSSLDRE----QVGSYHLVVSGA
DKDGEG--L-ATRCECSIK VK-DVNDNFPILRDSQ YS--AR-IEENTLSSDLLRF---HV
TDWDEEYTDNWLAEFFFTSGNEGNWFEIQTDPRTNEGILT-VV-----------------
---------------------------------------------------KALDYEQLQ
TLQLGIAVRNKAAFHHSI-ISKYRVQSTPVTIQ VINVREGITFRPASKTFTVQKVT-SSK
KLV DYILGTYQAIDEDTNKAASNV-----KYIMGRNDGGFLTIDSKTAQIKFVKNLDRDS
SFIVNKTIIAEVLA--IDE---TT-GKTSTGTVRVEIPHFSENCP-TAVLEKEAVCS---
S-SPV-VVSVRTLGNVKYTGPYTITLEETPVKLP-AVWSITTLNA--TSAL--LKAQQQV
SPGVYRIPLVITDNEDNRCETPESLTLE--VCQCDYRDTCGKYGPMTDP-----------
------------------------------------------------------------
-----------------------------YT------KDKHATSGRLGPAAIGLLLLGLL
----MLL--LAPLLLL--------------------TCDCGT-GPSGG--VASGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICLP-PIT------------
-------------------------------ANGADF-MESSEIC--------TNTYAGG
T-V--VEGT---S--GMEQTTKLGAANGSAGAAGFAAGAASGASAGFAGATGFGICPTGQ
S--GTMRTRHS-TEGTTRDYADG-V-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----TEPSSSPADALDCCSFIV-DDLDDSFLD
S-----LGPKFKQLAEIVLGLDD-KAKQGQPS---AKESGYVVDSCGR----SPEVPQE-
------------------------------------------------------------
---------GYVGCQTLPGREGASALS-ASMS-VQPAISI-PDPLQY-GKYWVTESYSA-
SGS-CVQ---SSAAGFDPLLTQNVKVTERGTCPMPCIP---GNLTGPT------QLRGSR
TVLCT--------------------------ED-----------PC--------------
--SQVI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWILLR---NA-----CLLIILMVSRIER
TR--GE-GSLEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGPGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDVNDNPPVFTQNV YTASIEENSDANALVVKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDRE----QHSMYSLLVRGS
DRDGATDGL-SSECDCRIKV L-DVNDNFPILEKTS YS--AS-IEENCLSSELIRL---QA
IDLDEEGTDNWLAKYLILSGNDGNWFDIQTDPQTNEGILK-VI-----------------
---------------------------------------------------KMLDYEQKP
NIHLSIGVKNQADFHHSV-ASQFQMHSTPVRIQVVNVREGPTFHPSSRTFNIGEGS-RGS
SLMNYVLGTYTAVDMDTGNTATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITNGIYIAEILA--IDD---GS-GKTATGTICIEVPDANDYCP-VVYADRRSLCT---
D-APSVLIYV---SDHSFGAPFTFCVVDQPPGTA-DIWSIRSINQ--TAAL--LMTEQVL
SPGLQQIPIIVKDSHNRACELPQIVLLD--ACLCDDNRMCLHSTTTGIYTGDI------S
------------------------------------------------------------
---------------SVTHDVYGT----------VTDDPVRQSNVRLGPAAIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVIQS---W-RIEGAHPEDRD------VSNICVPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGAG--TAAGLAAAG----A--------------------
A--GTLRKRSS-TMGTLREYPDS-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIRT------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNDSSGMT-LSEAEFQAEMAA-PEPVIH-GDIIVTETYSTT
--EPCVQ---PTTLVFDSQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAEIASTHNVYYAERVVSS-PGMPDVNTSNMTDA-------
--------CMGPVMAGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRQRITR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------------------------------------
----------GNILL-LSESKLLPK-HA-----HLVRQKRAWITFPVSLREGEDLSKKNP
VAKIHSDIEEKMGVKITYKYTGVGITEPPLGIFKFDENTGELNITSI-LDREQTPFFLLT
GYALNS--RGANLEKPLELRIKVLDINDNEPVFTERVFVGSVEELSEADTLVMKITATDA
DEPNTLNSKISYRILPPEPAH-PVFHLNKDTGEIFTTVFALDRE----EHSSYSLTVEAR
DGNGEVTDKPVHQAQVEI RIL-DVNDNIPIVEHEM YE--GT-VEENQVNVEVMRI---KV
TDADEVGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KVSGPGCR-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWSFFR--IA------AVLFIFL------
-----------VRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPADAPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEP---S--II-IEENTLYTDLMQI---RV
IDLDEEFSANWMAVIFFISGNEGNWFDIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAVN
NLQLSIGVRNKAEFHHSI-MSQYKLTAAAISVEVKNQREGPVFRPGSKTYVVTGN-----
MGANSKVGDFIATDQDTGRDSTT---AR--YVMGNNPADLLAVDSRTGIITLKNKVTKEQ
YNMLGGKYQGTVLS--IDD---DL-QRTCTGTINIDMQDFDFNGG---------------
-----------------------------------------DTTT--N------------
-----------------------------------------------------TGGTTND
N--------------TNTNTGST------------------------NNSRGDTSTQQGT
SA------------------------DEGN----HVGDQHLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCDGAA--AR--SVGGFEPVPE
CS-------DGAMHV---W-SEEGPQLDPTN-----TV----CVPPI----SG-------
------------A-------------------TNLIEFVDNTGVY--------TNEYDGR
KMH-DMGGGERV-----ELREEVNMSGMP------------------------ETCQ-EY
P--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEI-ESYPDPDP---SWPPQNTEPVCPPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--ATTVISESTY-PSGPGVQHPKPI-PDPLGY-GNVTVTESYTTS
-D--TLK---PSVHIHDNRQASNVVVTERVVGPISGVD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTL-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-TGVTGISGTSGIS--------
--------G--GIGSSGL-----VGTSMGSGG----------GALSGA--GISGSGMGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

MEARQKQLHGGRVEETAEMRAWSVGSCCRCLKVYEFRGLRKEEQQGDRKSHQSPLRREDS
TKIPAEWEKEKEQRTNEAPLVLDVRDAAAAMDWPPFT---A------AALLLCLVVA--E
VN--SE-FQIQVRDY-NAKNGTIK-WHS------SRRQKREWIKYAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPYFIIV
CRALNL--QGQDLERPLELRVRV LDINDNPPVFSMTTFI GQIEENSNANTLVMKLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRYTGEIRTMNNFLDRE----QYGQYSLAVKGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEHSS YN--IE-IAENALHSDLAQI---RV
IDLDEEYTDNWVAVIFFISGNEGNWFEIEMNEKTNVGILK-VV-----------------
---------------------------------------------------KPLDYEETK
NLQLSIGVRNKAEFHHSI-MSQYKLTATVVSVTVTNVVEGSVFRPGTKTYVVTSN-----
MEANSKVGEFVAIDMDTGLPSTT-----VRYVMGSNPADLLVVDSKTGILTLRNQVTMEQ
YQMLNKRYQGTILS--IDD---SL-HRTCTGTIIIDLDGSGWKTE---------------
-----------------------------------------GTST--V------------
-----------------------------------------------------SVQTTK-
---------------------ENGEETTFTE-----------PGG--ETSSRG-------
--------P------YVITDE-----NGGGTNGEREPYQRPGDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLI--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGVIHP---W-AAEGPQPAPG------DLTTICVPQIP----PG-------
------------G------------------GVTMMECIDNSGVY--------TNDYYGR
EMQ-DLGGGERTT--GFELMEGVKAPAAP------------------------DICQ-EY
S--GTLRR------NSMRECRE--G-------LN-MNFMENYFC----------Q---KA
YAYDEEDEGQPSNDCL---LIYDNES-I--------ASPAGSVGCCSFIG-EDLDESFLE
T-----LGPKFKKLADISLGIDT-EYYPDPDP---SWPPRNTEPVCPQQTT--------G
LV------------------------------------------------ASG---HPTV
SHH----------VG--ATTVISENTY-PSGPSVHHPMPI-SDPLGY-GNVTVTESYTTS
-G--TLK---PSVHLHDNLHGPNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PTPIESSNVVVT
--ERVIQPTSGMMGS-LSMHPDLSNAHNVVVTERVVSG-AGISGISGAAGISG-------
-----------AVGSSGL-----VSTNMGVSG----------SGLSGP--GVGGGGIGLG
SLGGGGGLSG-------SMAGTATISHVRNSSDHHFTQT-----LGSASPST-TRSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MAWLPF---RTT-----GALAILTVVL--L
VH--GE-LRIQTKGQ-YEEYETVIQ-QG------KRRYKREWVKFARPCREGEDNSNRNP
IAKITSDFEATQ--KITYHISGIGIDQPPFGIFVIDKNTGEINITAI-VDREVTPSFQIT
CRALNT--LGQEVEKPLILTVKI LDINDNAPVFSQSIF QGEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIISQEPAGTPMFLLSRHTGEVRTLTSSLDRE----QVSSYRLVVSGA
DRDGEG--L-STQCECSIK VK-DVNDNFPTFRESQ YL--AR-IKENTLSSELLRF---QV
IDLDEEFTDNWLAEFFFTSGNEGNWFEIQTDPQTNEGILQ-VV-----------------
---------------------------------------------------KSLDYEQVQ
SMQLGIAVKNKAEFHQSV-ISQYQVQSTPLIVE VINVREGITFRPSSKTFIVQKGV-SS R
QLINYVLGTYQAIDEDTGEVASFV-----RYVLGRNDGGLLTIDSNTAEIKFVKNIDRDV
TFIVNKTITAEVLA--IDE---NT-GKTSTGTIIVYVPDFNENCP-TIALEKEVVCS---
S-SPSVVVRASPLQRDKYAGPYEFSVEGQSVKLP-VAWSISGTDA--TSAL--LTAPQPV
SPGVYRISVVVTDGEGRRCETPESLTLE--VCQCDYRDTCRSAPPTSSP-----------
------------------------------------------------------------
-----------------------------HT------I--R-EGSRMGAAAIGLLFLGLL
----LLL--LALLLLL--------------------TCDCGA-GPIGG--VTGGFVPVPD
GS-------EGTIHP---W-GIEGAQPEDKE------ITNISVP-PIT------------
-------------------------------ANGVDF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTRLGAAAGSGGAAGFGA------------TAGLSNFSMGQ
S--GTMRTRHS-TGGTNKDFGEG-A-------IN-MKFLDSYFS----------Q---KA
FACADEDDGQEANDCL---LIYDNE--G----IEAPSSPVGSLGCCSFIA-DDFDESFLD
S-----LGPKFKKLAEISLGMDE-ETKNSQSP---TKDSSSRVDACDQ----HVQVQQS-
------------------------------------------------------------
---------ESVRHQTLSGSQGASALS-ASSSVLQPAISI-ADPLQH-GSYLVTETYSAS
SGS-LVQ---PPAAVFDPLLTQNVIVTERVICPIPSIT---SNLHGPT------ELRGSG
SKIFT--------------------------ED-----------PS--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MDS--KGNNLEKPLELRIKVLDINDNKPVFTQEVFTGSVEELSAPYTLVMKITATDA
DEPNTINSKISYRIVSQEPPYPVVFHLNTDTGEIFTTS-ALDRE----EHSSYSLTVEAK
DGYGQVTDHPVHQAQVQIR IL-DVNDNIPVVANGLLE--GT-IKENQVNVEVTRI---KV
IDADEVGSDNWLANFTFVSGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMK
NLDFNVIVTNKAAFHKSI-MNKYKPTPIPIK VKVTNVKEGISFKSSTISVHARE--GMDI
SSQ SQSIGKFQVFDEDTGQSA-NV-----KYVKVEDRDNWVSVDSVTSEIRLVKIPDFES
RYVQNGTYTVKIIA--VSQ--DDL-RKTITGTVLISVEDINDNCP-TLVNPVQSVCK---
D-APYVNVTAQDLDGYPNSWPFSFSVIDTPPGTA-AKWKIIHQES--TSVL---LQQDEH
KLGRSKIPFLITDNQGLSCLEKQVLELT--VCECLHGSGCVGA-----------------
------------------------------------------------------------
---------------------------------------QRTSYVGLGPAAIALIILALL
----LLL--LVPFLLL--------------------LCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPAILAV-----DHAENATVRNE
VG-----SAMANEGT-MKG---------SSSTSFFKVQQDQTNMD--GRWEEHRSLLGNG
ATQ--VTGTTGAR-LGAKTSWIRGT----L-----GASRE---------VA---------
-G----AHT------------------AAAGVVS-EEFLRNYFT----------D---KV
ASYTEEDDIHMAKDCL---LVYSQEE-T--------ASLHGSIGCCSFIE-GELDDRYLD
D-----LGLKFKTLAEVCLGRKI-DVDMEIEQR--QKLVKE----------TNL-STAAH
SLYEQTTVNS-------------------KNTYS--G-GSLP-----------------V
PKP--LQE---ASAEMVTQEVVTEKSV-SSRQGHKVTPPP-PDPLASDNI-IVTETSYTT
-GSTVS----PSTVILAPRQPQNLIVTERVYAPASTLV-------------DQH-YAGEG
NVVVT--------------------------ERVIQPSGTIPHPLQGSQHLHDAQYVMVT
EKESILAPGYGGQPT-LAMPNV---GQNVTVTERVL------------------------
-------TPASALDSRYQI---ASEASGKAGT-----A-----VISGA--GVPGPLPHS-
--------------------GLEGSGHSNS-------------------TITTSSTRVTK
HSTVQHSYT----------------

------------------------------------------------------------
------------------------------MDWLPHQTAAF--------LFLLLVLV--D
FS--TG-FHVEV-KE-WNGNGTAR-WKT------FRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEENN--PVTYSISGVGIDRAPYGIFVVNPRTGEINITSI-VDREVTPVFVIR
CFAKHS-VTGMDLEPPLELRVRVLDINDNPPIFAQSVFTGAVEECSMDNTLVMKIIASDA
DEPNHLNSKIAFKIESQEPSGQPMFIMNKYTGELH-LANYLDRE----QHSSYTLVVKAS
DRDGAADGI-SSLCNCHVK VI-DVNDNFPTLAQSS FS--AS-ISENSLSSEILRI---QA
LDADEEFSDNWLAEFFFISGNEDNYFEIVTDPATNQGILR-VI-----------------
---------------------------------------------------KELNYEHIP
THSLSIGVRNKAEFHHS V-ISQYQVFGTPLTIEVKNVIEPPRFNPSAIIL SVPQR-----
TRVNYVVGTYTAFDEDTGTTANNV-----IYTIGRDPGAWFKINKNTGEITLSKVIDWES
SYVMNGQYTAEVLA-VTKG---TP-RYTATGTIVLTMQDTRDNCP-AINTELRKVCM---
H-SPSVIITAKSIN-DQYALPFTFSIHG-EPQ---TTWIIRSINA--SSAE--LV-NQNM
DFYLYKISIRVRDSQGRTCLQPYVIPLQ--ACRCDSRNYCSSGATKIVIIGGGGAGGGGA
GGGGAGGGAGGAGGAGGGGTGGAGGGGAGGGGAGG--DGSQTGGGT-GQDYGGTGYEGGG
GSDSSTDSGTDTGGGSTNYDSYTGT--SDYGRNEYPGGYALPASTTLSGSAIGLMFLGGL
----IFV--CKYKIKKMVISTFLKVHVFIFQMTFLV--SCLL-LNSHG------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
-N--SE-FRIQVRDY-NAKNGTIK-WHS------MRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREVTPYFIIV
CRALNS--LGQDLENPLELRVRV LDINDNPPVFSMSTFI GQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDAPMFIINRYTGEVRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYLEQSA YD--IK-IEENALYSDLLPL---RV
IDLDEEFTMNWIAVIFFISGNEGNWFEIEMNERTNVGMLK-VV-----------------
---------------------------------------------------KPLDYEAVK
NLQLSIGVRNKAEFHHSI-MSQYKVVSTAISVIVTNVIEGAVFRPGSKTFAVTSN-----
MGANHKVGDFIAIDQDTNLPSTT-----VRYVMGNNPGDLLAVDSKTGILTLRKKVTFEQ
YQMLNGRYKGTILS--IDG---TD-SG---------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------TVPSTGGQDT-GGATGTSEEGITPNEDDTGKGT-QTNDNG-------
--------N------KDTNQN-----SG-G---------PGSDNVHFGPAGIGLLVMGFL
----ILG--LVPFLMI--------------------CCDYGGP---SG--GSAGFEPVPE
CS-------DGAIHP---W-AVEGPQPEPH------DMGTICVPAIP----AA-------
------------G-------------------ATMMECIDNSGVY--------TNDYCAR
EMQ-DLGGGERTT--GFELMEGVKTSAAP------------------------EICQ-EY
S--GTLRR------NSMRECREE-G-------LN-MNFMENYFC----------Q---KA
YAYADEEEGRPSNDCL---LVYDIEG-A--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKRLADISLGKEP-ECYPDPDP---SWPQ-NVEPVYPVKTT--------R
PV------------------------------------------------PSG---VPPV
SQQ----------VG--TTTVFSESTY-PSGPSIHHPMPI-SDPLGY-GNVTVTESYTTS
-G--SLK---PSVHLHDNLHAPNVVVTERVVGPISGAD-LHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTSLTI-PAPLESSNVVVT
--ERVIQPTSGMIGS-LGMHPDLSNAHNVIVTERVVSG-AGISGISGAAGISG-------
-----------GVGSSGL-----VSTNMGVSG----------SGLSGA--GISGGGI---
--------GG-------SMGGTATISHMRNSSDHHFTQT-----LGSASPST-TRSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------MDWHFLR--TA------TVLLIFLVVV--E
IN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFIINQKTGEINITSI-VDREITPFFIIY
CRALNS--LGQDLERPLELRVRV LDINDNPPVFSMSTF VGQIEENSNANTLVMRLNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYSQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEPSSHM--VR-IEENALSQNLVEI---RV
IDLDEEFSANWMAVIFFISGNEGGWFDIEMNERTNVGILK-VI-----------------
---------------------------------------------------KPLDYEAVQ
NLQLSLGVRNKADFHHSI-MSQYKVTATAISVTVLNVIEGSVFRPGSKTYVVRSD-----
MGQNYKVGDFVATDLDTGLASTT---V--RYVMGNNPANLLNVDSKTGVITLRNKVTMEQ
YEMLNGKYQGTILS--IDD---AL-QRTCTGTINIDLQGSGWEKD---------------
-----------------------------------------SEKV--T------------
-----------------------------------------------------SSQ-NSG
SSTGD-SSGGTGGGGRENPSEGD-------------TT--TNTGGK-TSTDYEDG-----
----------------ETQTQ------SN-NNHQELGSNNLSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLLM--------------------CCDCGGA---PG--AGAGFEPVPE
CS-------DGAIHS---W-AVEGPQPLPTD-----AT-TVCVPPIP----SD-------
------------N-------------------ANLIECIDTSGVY--------TNEYGGR
EMQ-DLGGGERTT--GFELTEGVKTSGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGKEV-E----PDP---SWPPESTEPICPQQGT--------E
PI------------------------------------------------IGG---HPPI
SPH----------FG--TTTVISENTY-PSGPGVQHPMPI-PDPLGY-GNVTVTESYTTS
-G--TLK---PTVHVHDNRHASNVVVTERVVGPISGTD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTM-PDPRESSNVVVT
--ERVIRPASGMMGN-LSIHPELSNAQNVIVTERVVSG-SGISGISGPAGIS--------
--------GGSGLVG------------------------------SAM--GVSGGGIGLN
SLGGGGGLSS-------SMGGTATIGHVRSSSDHHFSQT-----LGSASPST-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
------------------------------MDWSFFR--VA------AVLFIFLVVV--E
VN--SE-FRIQVRDY-NTKNGTIK-WHS------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNS--MGQDLERPLELRVRV LDINDNPPVFSMATF AGQIEENSNANTLVMILNATDA
DEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDRE----QYGQYSLAVRGS
DRDGGADGM-SAECECNIKI L-DVNDNIPYMEQSS YT--VN-IEENTLNSNLLEI---RV
IDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRN KAEFHHSI-MSQYKLTASAISVVVLNVIEGPVFRPGSKTYVVTGN-----
MGS NDKVGEFVATDLDTGRPSTT---VR--YVMGNNPADLLAVDSRTGKLTLKNKVTREQ
YDMLGGKYQGTILS--IDD---RYSQRTCTGTININIRSFDEGGR---------------
-----------------------------------------T-----N------------
-----------------------------------------------------TQPNTEI
T--------------TNTGRQES----------T-------------SSISYDTSTISTA
SS------------------Q-----EHSSGSTNILDVPVFSDNVHFGPAGIGLLIMGFL
----VLG--LVPFLMI--------------------CCDCGGA---PR--SAAGFEPVPE
CS-------DGAIHS---W-AVEGPQPEPRD-----IT-T-VIPQIP----PD-------
------------N-------------------ANIIECIDNSGVY--------TNEYGGR
EMQ-DLGGGERMT--GFELTEGVKTSGVP------------------------EICQ-EY
S--GTLRR------NSMRECREG-G-------LN-MNFMESYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDDSFLD
T-----LGPKFKKLADISLGK---ESYPDLDP---SWPPQSTEPVCLPQET--------E
PI------------------------------------------------VSG---HPPI
SPH----------FG--TTTVISESTY-PSGPGVQHPMPI-LDPLGY-GNVTVTESYTTS
-D--TLK---PSVHVHDNRPASNVVVTERVVGPISGAD-LHGML------EMPDLRDGS-
NVIVT--------------------------ERVIAPSSSLPTSLTI-HHPRESSNVVVT
--ERVIQPTSGMIGS-LSMHPELANAHNVIVTERVVSG-AGVTGISGTTGIG--------
--------G--GIGSSGL-----VGTSMGTGG----------GALSGA--GISGGGIGLS
S-----------------LGGTATIGHMRSSSDHHFNQT-----IGSASPST-ARSRITK
YSTVQYSK-----------------

------------------------------------------------------------
------------------------------XXXSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLTEERGLKVTYKYTGKGITEPPFGIFVFNKDTGELNITSI-LDREETPFFLLT
GYALDE--RGNNVEKPLELRIKVLDVNDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVTNKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISTYVSE--S MDR
SSKGQIIGKFQAFDEDTGLLA-RA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTITGTVLIYVEDINDNCP-TLIEPVQTICN---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDEPPGMA-EKWKIVHQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPEKQMLTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGGK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGESLGGRNG
VG-----GMA-KEAT-MKG---------SSSASFAKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--VTGATGAI-MTTETTKTARA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFS----------D---KA
ASYTEEDGNHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SPYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
SKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNI-IATETSYVT
-GSTVP----PSTVILGPRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERIIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSAGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSVKARN-----T-----MVSGA--GVLGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHSYS----------------

------------------------------------------------------------
------------------------------MMGLFP---RAT-----GTLAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECNIK VK-DVNDNFPMFRDSQ YS--AR-IEENIVSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKSFTVQKGI-SST
K LVDYILGTYEAIDEDTKKAASNV-----KYVMGRNDGGYLTIDSKTAEIKFVKNMDRDS
TFIVNKTITAEVLA--IDE---YT-GKTSTGTVYVRVPGFNDNCP-TAVLEKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALENQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------KYGRPHS-RLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKDSGYGIESCGH----PIEVQQT-
------------------------------------------------------------
---------GFVKCQTLSGSQGASALS-ASGS-VQPAVSI-PDPLQH-GNYVVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLQGSH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------ICF--N
VG---SGLHLQVLST-RNENKLLPK-YP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSA-------------
------------------APYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GT-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEIK
NLDFSVIVANKAAFHKSI-RSKYKPTPIPIK VKVKNVKEGIHFKSSVISIYVSE--SMDR
SSKGQIIGKFQAFDEDTGLPA-HA-----RYVKLEDRDNWISLDSVTSEIKLAKLPDFES
RYVQNGTYTVKIVA--ISE--DYP-RKTVTGTVLINVEDINDNCP-TLIEPVQTICH---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQSEK
KLGRSEIQFLISDNQGFSCPQKQILTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGTK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFRPV-----DQGDNLVGRNG
VG-----GMA-KEAT-MKG---------SSSASIAKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--VTGATGVI-MTTETTKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KA
ASYTEEDENHTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SLYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPVASRNV-IATETSYVT
-GSTVP----PTTVILGSRQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
RSTVQHSYS----------------

------------------------------------------------------------
------------------------------MGWFAL---RTA-----GALVILMVAV--E
VN--SE-FWVEXXXX-XXXXXXXXXXXX------X-XXXXXXXXXXXXXXXXXXXXXXXX
XXXITSDFQKTQ--KITYRISGVGIDKPPYGIFVVNPRTGEINITAI-VDREETPMFLXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTLMMVLNATDA
DEPNHLNSKIAFKIVSXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX
XXXXXX--X-XXXXXXXXXXX-X-XXXXXXXXXXXXX--XX-XXXXXXXXXXXXX--XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-----------------
---------------------------------------------------XALDYEQFQ
TMQIGIAVKNKAPFHQSI-ISQYRIQSIPVKVEVINVKEGIAFKPTSKTFTVQKGI-SYK
QLTNYILGPFPAIDEDTGKPATLV-----RYAMGRNDGGFLAIDSKTAQIKFVKNLHRDS
TFIVNKTLTAEILA--IDD---NT-GKTSTGTVIVRV PDFNENCP-MVFT DKRSVCR---
T-SASVVVTAKPLPNQPNNGPFTFSLVEQPLGTQ-AMWSITTIND--TSAN--LRAQRAL
SSETYALSLIVTDRQGNSCEIPETLELQ--TCDCDERNMCRVPFPTIKP-----------
------------------------------------------------------------
-----------------------------ET------RQRGTPLASLGPAGIGLLILGLL
----MLL--LAPLLLL--------------------FCDCGAGPGLGG--VGFGFLPVPD
GS-------EGTIHQ---W-GIEGAQPQDKE------ITNICVP-PIT------------
-------------------------------VNGTEL-MESSEVC--------TNAYATE
T-V--VEGT---S--GIELTTRVRAASGSGGTPGL--------------------GGTGY
S--GTMRTRHS-TGGTIRECAEG-S-------VS-MTFLDSYFS----------Q---KA
FACSEEDDSQGVNDCL---LIYDDEG-G-----EPPSSP---VGCCSFIV-DDFDDSFLD
S-----LGPKFKKLADISMGIDH-ETKFSQA-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MARSPGRA---------YALLLLLICF--N
VG---SGLHLQVLST-RNENKLLPK-HP-----HLVRQKRAWITAPVALREGEDLSKKNP
IAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLT
GYALDA--RGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDA
DEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDRE----EHSSYTLTVEAR
DGNGEVTDKPVKQAQVQIR IL-DVNDNIPVVENKVLE--GM-VEENQVNVEVTRI---KV
FDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LI-----------------
---------------------------------------------------KEVDYEEMK
NLDFSVIVANKAAFHKSI-TSKYKPTPIPIK VKVKNVKEGIHFKSSVISIYVSE--S MDR
SSKGQIIGKFQAFDEDTGLPA-HA-----RYVKLEDRDNWISVDSVTSEIKLAKLPDFES
RYVQNGTYTVQIVA--ISE--DYP-RKTITGTVLINVEDINDNCP-TLIEPVQTVCH---
D-AQYVNVTAEDLDGHPNSGPFSFSVIDKPPGMA-EKWKIARQES--TSVL---LQQNEK
ELGRSEIQFLISDNQGFSCPEKQILTLT--VCECLHGSGCREA-----------------
------------------------------------------------------------
---------------------------------------QHDSYVGLGPAAIALMILAFL
----LLL--LVPLLLL--------------------MCHCGKGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSFLPV-----DQGDSLVGRNG
VG-----GMA-KETT-IKG---------SSSASIAKGQHEMSEMD--GRWEEHRSLLSGR
ATQ--FTGATGAI-MTTEATKTTRA----T-----GASRD---------MA---------
-G----AQ-------------------AAAVALN-EEFLRNYFT----------D---KV
ASYTEEDENYTAKDCL---LVYSQEE-T--------ESLNASIGCCSFIE-GELDDRFLD
D-----LGLKFKTLAEVCLGQKI-DINMEIEQR--QKPATE----------TSM-NTASH
SLYEQTMVNS-------------------ENTYS--SGSSFP-----------------V
PKS--LQE---ANAEKVTQEIVTERSV-SSRQAQKVATPL-PDPMASRNV-IATETSYVT
-GSTMP----PTTVILGPSQPQSLIVTERVYAPASTLV-------------DQP-YANEG
TVVVT--------------------------ERVIQPHGGGSNPLEGTQHLQDAPYVMVR
ERESFLAPSSGVQPT-LAMPNI-AVGQNVTVTERVL------------------------
-------APASTLQSSYQI---PTENSMKARN-----T-----MVSGA--GVPGPLPDF-
--------------------GLEESGHSNS-------------------TITTSSTRVTK
HSTVQHTYS----------------

------------------------------------------------------------
------------------------------MDWHSFR--IA------AVLLIFLVVL--E
VN--SE-FHIQVRDH-NAKNGTIS-WHT------IRRQKREWIKFAAACREGEDNSKRNP
IAKIHSDCAANQ--QVTYRISGVGIDQPPYGIFVINQKTGEINITSI-VDREVTPFFIIY
CRALNA--QGQDLENPLELRVR VMDINDNPPVFSMTTF TGQIEENSNANTLVMKLDATDA
DEPNNLNSKIAFKIIKQEPSESPMFIINRGTGEIRTMNNFLDRE----QYSQYSLVVRGS
DRDGGADGM-SAECECNIRI L-DVNDNIPYLEQSS YA--IS-IEENALHSQLVQM---RV
IDLDEEFSDNWKAVLFFISGNDGNWFEIEMNERTNVGILK-VV-----------------
---------------------------------------------------KPLDYEAMQ
NLQLSIGVRNVAEFHQSI-ISQYRITATMITVNVLNVIEGSVFRPGSKTFVVNSQ-----
MGANYKVGDFTATDLDTGLIS-----TNVRYVMGNNPADLLDVDSRTGIITLRNRVTMEQ
YQMLNKRYEGTILS--IDD---NL-QRTCTGTVIIDLDGSGWVTS---------------
-----------------------------------------TDTN--T------------
-----------------------------------------------------SGGGGST
GGGGSAGSG-TSENTSTEETQVTTGS-----------W--ENG-----------------
-----------------------------------------GDNVHLGPAGIGLLVMGFL
----ILG--LVPFLLL--------------------CCDCGGA---PG--GGAGFEPVPE
CS-------DGAIHT---W-AVEGPQPEPHD-----GIATICVPQMP----PG-------
------------N-------------------ANIIECIDNSGVY--------TNEYCGR
EMQ-DLGGGERTT--GFELMDGVKASAGP------------------------EICQ-EY
S--GTLRR------NSMRECRDG-G-------LN-MNFMENYFC----------Q---KA
YAYADEDEGRPSNDCL---LIYDIEG-V--------GSPAGSVGCCSFIG-EDLDESFLD
T-----LGPKFKKLADISLGKEI-DSYPDPEP---SWPPQSTEPICLQQ-T--------E
PL------------------------------------------------NSG---HPPI
SPH----------FG--TTTVISENTY-PSGPAVQHPMQI-PDPLGY-GNVTVMESYTTS
-G--TLK---PSVHFHDNRQASNVVVTERVVGPISGAD-LHGML------EIPDLRDGS-
NVIVT--------------------------ERVIAPGSSLPTTLTI-PNPREPSNVVVT
--ERVIQPTSSMMGN-LSMPPELSNAHNVIVTERVVSG-AGVSGISGATGIG--------
--------GVGGVGGSSL-----VSTTMGASG----------GA-------------L--
---------S-------SMGGTATIGHMKSSSDHHFSQT-----VGSASPSM-ARSRITK
YSTVQYTK-----------------

------------------------------------------------------------
--------------------------------MSLGVACPGYS--SWRGFDPDKICF--T
FG---NGLHLETLNT-RSDSRLLPK-HT-----HLVRQKRAWITAPVSLREGEDLSRKNP
IAKIHSDIAEERGVKITYKYTGVGITEPPFGIFVFNKDTGELNVTSI-LDREETPFFLLM
GYALDS--RGNNLEKPLELRIKVLDINDNEPVFTEEVFVGSVEELSAAHTLVMKIIATDA
DEPNTMNSKISYRIVSQEPAYPPVFYLNKDTGEIYTTSIALDRE----EHSSYSLTVEAK
DDNGQITDKPVHQAQVQIR IL-DVNDNIPVVEREM YE--GM-IEENQVNVEVMRI---KV
TDADELGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVT-LV-----------------
---------------------------------------------------KEVDYETMK
NLDFSIIVTNKAAFHKSI-RNKYKPTAIPIK VKVNNVKEGIHFKSSTISVRTSE--GMDK
S SQSQSIGKFEVFDEDTGQSP-HV-----KYVKLEDGDNWVSVDSVTSEIRLVKIPDFES
RYVHNGTYTVKVLA--VSQ--DHP-RKTITGTVLITVEDINDNCP-TLVNPVQSICE---
D-QPYVNVTAEDLDGHPNSWPFSFSIIDTPPGMT-EKWKIIRQES--TSVL---LQQGER
QLGRSEIPLLISDNQGFSCPEQQVLQLM--VCECLQGSGCVEA-----------------
------------------------------------------------------------
---------------------------------------QRGSYVGLGPAAVALMILALL
----LLL--IVPLLLL--------------------LCHCGEGAK--GF------TPIPG
-T-------IEMLHP---W-NNEGAPPEDKV------VPSLLAV-----DHGENLAARNG
VG-----GAITKEAT-RKG---------SSSASFSRVQHDLTEAN--GRWEEHRSLLSGA
AAQ--ATGTAGAQ-LGAETMRTVRA----V-----GASRD---------AT---------
-G----ARA------------------ASAGAVS-EEFLRDYFS----------D---KA
ASYSEEDDIHVAKDCL---LVYSQEE-T--------ESLHGSVGCCSFIE-GELDDSFLD
D-----LGLKFKTLAEVCLGQKI-DVDMEIEQR--PKPVKE----------TNL-TRAAH
SLYEQTTFNS-------------------ENTHS--SGSSFQ-----------------V
PKP--LHE---TKAEKLTQEIVTERSV-SSRQGQKVAPPL-PDPLASGNI-IMTETSYTT
-GSAMP----PSTVVLGPGQPQSLVVTERVYAPASTLV-------------GQQ-YAGES
NVVVT--------------------------ERVIQPNGGVPHPLGGTQHLQDAQYVMVR
EXXSVLAP------T-LATPSAAAVGQNVTVTERVL------------------------
-------TPASTLESSYQI---ATEASGKAGR-----A-----MVSGA--GVPGPLPHS-
--------------------GLEGSGHSDS-------------------TITTSSSRVTK
HSTVQHSYA----------------

------------------------------------------------------------
------------------------------MDWLLLR---NI-----CLLIILMVVL--E
VN--SE-FIVEVKEL-DIENGTTT-WQT------VRRQKREWIKFAAACREGEDNSKRNP
IARIRSDCEVNQ--KITYRISGAGIDRPPYGVFTINPRTGEINITSV-VDREITPLFLIY
CRAL--NSRGEDLERPLELRVK VMDINDNPPVFTQNV YTASIEENSDANALVIKLSATDA
DEDNHLNSKIAYKIISQEPAGAPMFIVNRYTGEVRTMSSFLDRE----QHSMYNLLVRGS
DRDGAEDGL-SSECDCRIKV L-DVNDNFPILEKTS YS--AS-IEENCLSSELMRL---QA
IDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KTLDYEQVP
NVNLGIGVKNQADFHHSV-ASQFRMHSTPVRIQ IVNVREGPTFHPSSMTFRVREGI-RGD
SL LNHVLGTYTAIDMDTGNPATNV-----RYVIGHDAGKWLKVDSRTGEIQFSREFDKKS
KYITNGMYTAQILA--IDD---GS-GKTATGTICIEVPDVNDYCP-VICLESSTTCM---
V-SPSVPIYV---SDHSYGAPFTFCVVDEPPGTA-DIWNIEPING--TFAI--LTTDEVI
SPGLHQIPILVKDSYNRACELPQIVQFD--ACSCDSNGICLHSSTPGIHIEDI------S
------------------------------------------------------------
---------------SSPDDMYGT----------ITDDQAGDSNVGLGPAAIGMMAMGGL
----LLL------------------------------CKYCIKST---------FSA---
------------------------VLQNRAD------VSNICAPM---------------
------------T------------------ASNTQDRIDSSEIY--------TNTYAGG
GTV--EGGV---S--GVELNTGVG--MAEGMVAGG------------------------T
M--GTLRKRSS-TIGTLREYADT-G-------MN-MAFLDSYFS----------E---KA
YAYADEDEGRPANDCL---LIYDHEG-V--------GSPVGSIGCCSWIV-DDLDESYME
T-----LDPKFRTLAEICLDTEI-EPFPS-HQ---ACIPIST------------DLPLLG
PNY---------------------------------------------------------
-----------------F-VNESSGMT-LSEAEFQAEMAA-SEPMIH-GDIIVTETYTTT
--DPCVQ---PTTIVFDPQLPPNVVVTETVMAPVYDVQ---GN-----------------
------------------------------------------------------------
----------------ICVPAELANTHNVYYAERVLSS-PGMPDVNNGSMTDG-------
--------CMGPVMSGG---------------------------------ILVGPEIQVT
Q---------MV-----------------S-PDIHISQT-----IGSTSPMT-SRHRVTR
YSNIHYSQQ----------------

------------------------------------------------------------
------------------------------MMGLLP---RTT-----GALAIFMVVI--L
VH--GE-LRIEMKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AH-IEENTLSSELLRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVQLGIAVKNKAEFHQSV-ISRYRVQSTPVTIEV TNVREGIAFRPASKTFVVQKGI-SSK
KL VDYILGTYQAIDEDTRKAASNV-----KYVMGRNNGGYLMIDSKTAEIKFVKNVDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVSARTLN-NRYTGPYTFALEDQPVKLP-AVWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTSP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPHSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TNTYARG
T-V--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSGAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYADG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-EGKQVQPP---SKGSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MDWLLFR---NI-----CLLIILMXX--XX
XX--XX-XXXXVKEL-DVENG-TK-WQT------VRRQKREWI-FAAACREGEDS--KNP
IAKIRSDCEVNQ--KITYRISGVGIDRPPYGVFTINPRTGEINITSV-VDREITPIFLIY
CRAL--NSRGEDLEMPLELRVKV MDINDNPPVFTQNV YVASIEENSDANTLVVKLSATDA
DEDNHLNSKIAYKIISQEPTGAPMFSLNRYTGELCTMSTFLDRE----QHSMYNLLVRGS
DRDGAADGL-SSECDCRIKV L-DVNDNFPKLEKAS YS--AS-IEENCLSSELMRL---QA
LDLDEEGTDNWLADYLILSGNDGDWFDIQTDPQTNEGILK-VV-----------------
---------------------------------------------------KMLDYEQMP
NIQLSIGVKNQAEFHHSV-ASQFQMHSTPVRIQV INVREGPTFHPNS MTFSIREGI-KGN
SLLNYVLGTYTAVDLDTGNPATNV-----RYIIGHDAGSWLKVDSRTGEIQFSREFDKKS
KYITDGIYTAEILA--IDD---GA-GKTATGTVCIEVPDINDYCP-VISAESKTICI---
D-SPSVLISARDISGHSHGSPFTFCVVDQAPGTA-DLWDIRSINA--TSAI--LMAVQPL
FPGLYQIPILITDSYGRACEIPQILQLD--ACDCDSNHMCLYSSTTSIST--E----VIS
------------------------------------------------------------
---------------VATGDVYGS----------VTDDRTGDSNVGLGPAGIGMIVLGLL
----LLL--LSPLLLL--------------------MC-CCKRRQPEG--LGTRFAPVPE
GG-------EGVIQS---W-GIEGGHPEDRV------SSSYFVLCCAGLA----------
-------GSISSA------------------RTMQATHPSLSEIY--------NNTYAGG
GTA--EGGA---S--GVELNTGLG--ITTGLVAVG------------------------G
G--GAMRRRSS-TIGTLREYAET-G-------MN-MAFLDSYFS----------E---XX
XXXXXXXXXXXXXXXX---XXXXXXX-X--------XXXXXXXXXXXXXX-XXXXXXXXX
X-----XXXXXXXXXXXXXXXX--XXXXXXXX---XXXXXXX------------XXXXXX
XXX---------------------------------------------------------
-----------------X-XXXXXXXX-XXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXX
--XXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX-----------------
------------------------------------------------------------
----------------XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-------
--------XMGPVMSGN---------------------------------IMVGPEIQVM
Q--------------------------M-ANPDLHMSQT-----VGATSPMT-SRHRVTQ
YSNIHHSQQ----------------

------------------------------------------------------------
------------------------------MMGLLP---TTT-----GALAIFMVVI--L
VH--GE-LRIETKGQ-YDEEEMTVQ-QA------KRRQKREWVKFAKPCREGEDNSKRNP
IAKITSDYQATQ--KITYRISGVGIDQPPFGIFVVDKNTGDINITAI-VDREETPSFLIT
CRALNA--QGLDVEKPLILTVK ILDINDNPPVFSQQIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDRE----QASSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFRDSQ YS--AR-IEENTLSSELIRF---QV
TDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVKLSIAVKNKAEFHQSV-ISRYRVQSTPVTIQ VINVREGIAFRPASKTFTVQKGI-SSK
KL VDYILGTYQAIDEDTGKAASNV-----RYVMGRNNGGYLMIDSKTAEIKFVKNMDRDS
TFIVNQTITAEVLA--IDE---YT-GRTSTGTVYVRVPGFSDNCP-TAVLDKDAICS---
S-SPSVVVTTRTLN-NRYTGPYTFALEDQPVKLP-AIWSITTLNA--TSAL--LRAQEQI
APGVYHISLVLTDSQNNRCEMPGSLTLE--VCQCDNRGVCGTSYPTTWP-----------
------------------------------------------------------------
-----------------------------GT------RYGRPPSGRLGPAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDCGA-GSTGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAHPEDKE------ITNICVP-PIT------------
-------------------------------ANGADF-MESSEVC--------TSTYARG
T-A--VEGT---S--GMEMTTKLGAATESGGAAGFATGTVSAAASGFGAVTGVGICSSGQ
S--GTMRTRHS-TGGTNKDYTDG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDGQEANDCL---LIYDNE--G----ADATGSPVGSVGCCSFIA-DDLDDSFLD
S-----LGPKFKKLAEISLGVDG-ESKQVQPP---SKDSGYGIESCGR----STEVQQS-
------------------------------------------------------------
---------GFIKCQTLSGGQGASALS-ASGS-VQPAVSI-PDPLQH-GNYLVTETYSA-
SGS-LVQ---PSTAGFDPLLTQNVIVTERVICPISSVP---GNLAGPT------QLRESH
TMLCT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------MTWLLF---RTS-----GALAILMVLI--L
VH--GE-LRIETKGQ-HGEDETAI--QG------RRRYKREWVKFAKPCREREDNSRRNP
IAKITSDFQATQ--KITYRISGMGIDQPPFGIFVVDKNTGEINITAI-VDREETPSFQIT
CHALNV--LGQDVEKPLILTVKI LDVNDNAPVFSQSIFM GEIEENSASNSLVMILNATDA
DEPNHLNSKIAFKIVSQEPAGTPMFLLSRHTGEVRTLTNSLDRE----QVSSYRLVVSGA
DKDGEG--L-STQCECSIK VK-DVNDNFPMFKESQ YS--AH-IKENTLTSELLRF---QV
IDWDEEFTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILK-VV-----------------
---------------------------------------------------KALDYEQLQ
SVQFSIAVKNKAEFHQSV-ISQYQVKSTPVTIQ VVNVKEGIAFHPASKTFTVRKGI-SSK
KLVNYVLGTYQAIDEDTNKAASYV-----KYVMGRNDGGLLFIDPKTAQIKFVRNIDRDS
TFIVNKTITAEVLA--IDE---NT-GKTATGTIYVEVPGFNENCP-TVVLEKKAICS---
S-LRSVVVSARV-PDNKYTGPYTFSLEEQSLKLP-VVWSITTLNA--TSAL--LNAQQQL
SPGEYTISLTVTDSQDRQCETPESLTLE--VCQCDNRDICRSSNGNKDY-----------
------------------------------------------------------------
-----------------------------ER------LDGKRPSGRLGSAAIGLLLLGLL
----LLL--LAPLLLL--------------------TCDYGV-GPIGG--VTGGFIPVPD
GS-------EGTIHQ---W-GIEGAQPEDKE------ITNICVP-PIT------------
-------------------------------TSGADF-MENSEVC--------TNTYAGG
T-V--VEGA---S--GMELTTKLGAATGSGAAAGFGAT------AGFGAATGLGIGSAGQ
S--GTMRTRHS-TGGTNKDYGEG-A-------IS-MNFLDSYFS----------Q---KA
FACAEEDDVQEANDCL---LIYDNE--G----MGAPSSPVGSLGCCSFIA-DELDDSFLD
S-----LGPKFKKLAEISLGIDD-EAKQSQPL---SKASLSGMESCGY----SLEVQQP-
------------------------------------------------------------
---------ESVRGQTLLGSQGASALS-ASSSVLQSATSI-PNPVQH-GSYMVTETYSA-
SGS-LVQ---PTTTVLEPLLTQNVTVTERVICPISNVS---GNLQTPM------ELRGSR
NMICT--------------------------ED-----------PC--------------
--SRLI------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------EYSSYTLTVDVR
NENVQITDRPAKQAQVQIRIL-DVNDNIPVVQNEVLE--GL-VEENQVNVEVMRI---KV
FDKDEVGSDNWLANFTFASGNG---YHIELDARTNEXXXX-XX-----------------
---------------------------------------------------XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX--XXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----XYSKLEDTGNWISIDSATSEIRLVKIPDFES
TYVQNGTYTVKILA--ISE--DYP-RKTITGTIAINVEDINDNCP-TLVNPVHNICD---
D-VQFVNVTAEDLDGPKYSGPFSFSIIDKPPGTG-EKWKIVRHES--TSLL---LQQKEL
KIGRSEIPFLISDSQGFSCPEKQILTLT--VCKCLDSSGCVGA-----------------
------------------------------------------------------------
---------------------------------------LRDSYVGLGPAAIAIMIFAFL
----LLL--LIPLLLL--------------------MCPCGKGTK--GF------APIPG
-T-------IEMLHP---W-NNEGAPPEDKA------VPSMLVA-----DHRESLAIGNG
IG-----GMLSKDTT-MKG---------SSSASYTKGQHEMSEMD--GRWEEHRNLLTGG
AAH--FAGTAGAI-SATENTRSARV----P-----GSSRD---------II---------
------------------------GSGAAAAAVS-EEYLRSYVT----------E---XX
XXXXXXXXXXXXXXXX---XXXXXXXXX--------XXXXXXXXXXXXXX-XXXXXXXXX
X-----XXXXXXXXXXXXXXXXX-XXXXXXXXX--XXXXXX----------XXX---XXX
XXXXXXXXXX-------------------XXXXX--XXXXXX-----------------X
XXX--XXX---XXXXXXXXXXXXXXXX-----XXXXXXX--XXXXXXXXX-X-XXXXXXX
-XXXXX----XX--XX--XXXXXXXXXXXXXXXXXXXX-----X-------XXX-XXXXX
XXXXX--------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX-XXX-XXXXXX---XXX---XXXXX-------------------XXXXX
XXXXXXTERPPFTASSYQI---PAESS----------VRIRKTMVSGT--GVPDTLPSL-
--------------------DLEDSGHSHA-------------------TVTTSSTRVSK
HSTVQRAFS----------------

Query Results

"ENSGT00910000144083_0"

ENSGT00910000144083_0