Query Results 

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
EQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTITSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSNLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILRQACKRMAEEAKQKEDQNT----GSTLDQEAR--
----LSKVTPSTAPVPGL------KATPQESSLLAGLLASEMKNNWEDWGAGEAPPTPR-
ENHITLECEQAFPELRPET-------M--GRRSTDAVDPE--NE-EPDSDDEWQRLLETM
EPVPVQLKSPLTLLCNPDFCQHIQSQLRGTGEQILKGVLDGASHLLPALRILSSLLS-SC
SD---------------SVLLYSFCQEVGLPELPLSLLRYSQESSSIQQQPWYGAFLREL
VAVVQAYFSCTFNLERSQTGD--SLQVFEEAASLFLDLLGKLLAQPDDSEPTFRRDSLMC
FAVLCEAVDGNSRAISK-------AFYASLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLISGLRHHILCLHLLKVLYSCCYISERLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHIVSL--VN-A
AACLLGQLGQQGVTFDLQPREWIAAAA--HALSAPAEVRLTPPCSCGFYDG-LLVLLLQL
LTQGKP---GL---IRDVAGSEVWTILWHRFSMALRLSEEVSAQEDDLSL-SSPP---SL
EPDWTLISPQGMAALLSLAMAIFTQEP--QLCLSHLSQHGSVLMLTLKHLLSPSFLHRLS
QAPQ-----GSEFLPVVVLSVCKL----LCFPFALDVDADLLGGILADLRASEVAVYLLQ
VCCHHLPLFQAELPIGLLTRLALMDPTSLKQFVNTVATSSRAIISFLSVVLLCDQPLMVS
DLLSLLTHTTRILSPSHLSFIQELLSGSDESYRPLRSLLGHSENAVRVRTYRLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQDAIRRNAASALGNLGPE--GLG-KELLKCQVPQRLLEMACGDPQPTVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLTLLSLGHQLLP-------SSNSRPTSARHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFELVSLILKDPVRW
PSTLSPCFKNFLQGLLTKDPRQRLSWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GHVTIITEPAALDLGTPFTSR
LPPELQVLKDEQAHRLAPKGSESRILRQARKRMAEEAKQKKHQNT----ESALEQEDR--
----TSKVAPGTAPLPRL------RATPQEPGLLAGILASEMKSSWAEWGAGEAPSTPR-
EHQITVDCEQAFPELKSEV-------V--GQRSIDAVDLENE---EPDSDEEWQHLLETI
KPVPIQLKSPLTLLCNPDFCQRIQSQLQETGGQILKGILEDVSHMLPALRVLSSLLSG-C
SD---------------SVALYSFCREAGLPGLLLSLLKHSQESTNIQQQSWYGTFLRDL
IAVIQAYFACTFNLERSQTSD--SLQVFQEAVSLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVVCEAMDGNSRAISQ-------AFYSSLLTTQRAVLDGLLQGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAISCALAAICTAPVGLPGCWEAKEQVSRYLANQLTEDSSQL
RPSLVSGLQHPILCLHLLKVLYSCCHVSERLCHLLGQEPLA-LESMLMLVQGKVKV----
MDW--EESTEVALYLLSLLVLRLQDLPSGMEKLGS-----ETATLFTHSHVVSL--VS-A
AASLLEQLCQQGVTLDLQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQV-RGKTSL---IRDMASSEMWTILWHRFSMALRLPEEVSTQEEELSL-SSPQ---SP
EPDWTLISPQGMAALLSLAVATFTQEP--QLCLSHLSQRGSILMSTLKHLLSSSFLHQLG
QAPH-----GSEFLPAVVLSVCQL----LCFPFALDVDADLLIGILADLRDSEVAAHLLQ
VCCHHLVLPQVELPMSLLTRLALTDPTSLSQFVNTVAASPSSIISFFSVALLGDQPLLTS
DLLSLLAHTARVLPPSHLSFIQELLAGSD

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPDNSVRARTYGLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1268)

SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDLAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPG
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-EEMLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLSLG-----NQLLPHSGSSPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF07714 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELKNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPASLDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILLQACKRMAEEAKQK-QQDT----GSALEQEDR--
----TNKVASDTTP-SRL------RATPQESSLLAGILASEMKSSWAEWGAGEAPLTSR-
ENWITPDSEQAFPELRPAV-------M--CQRSIDAVDLENEXX-XXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXILKGILEGASCILPALRVLSSLLSS-C
SD---------------SVLLYSFCREAGLPGLLFSLLRHGLENNSIQQXXXXXXXXXXX
XXXXXXX--XXXXXXXXXXXXXXXLQVFQEAANLFLDLLGKLLAQPDDFEQTLRRDSLMC
FIVLCEAMDGNSRTISK-------AFYSSLLTTQWVVLDGLLRGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAISAALAAICTAPVGLPSCWEAKEQVSRHLASQLTEDSSQL
RPSVISGLQHPILCLHLLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----
XXX--XXXCGVTLYLLSLLALRLQDLPSGMEKLGD-----EIATLFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWIAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTQ--QGKASL---IRDVTNSEMWTILWHRFSMALRLPKEVPSQEDELLL-SSLP---SP
GPDWTLISPQGMAALLSLAVTTFTQEP--QLCLSHLSQRGSVLMSTLKHLLSPSFLHQLG
QAPH-----GSEFLPVVVLYVCQL----LCFPFALDVDADCLADILADLRDSEVTAHLLQ
VCCHHLPLPQIELPVSLLTRLALTDLASLNQFVSTVAASPRTIISFLSVALLSDQPLLTA
DL-SLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARTHGLLGHLLQH
SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPS
MTQLLVDPQASIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLP-------NSSPRPTSAKHCRKLI
HLLRPTHST-

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 270)

VLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTILTEPAGPDFGTPFTSR
LPPELQVLKDQQAHRLAPKGNRSHILRQACKRMAEEAKQKKHQNI----GPPLEQEDR--
----TSKVAPGTAPLPKL------KDTPQEPGLLTGVVASEMKSSWAEWGAGEAPPVPR-
ENWITQDCERAFPELRLEV-------M--GQQSLDAVDLENE---EQDSDDEWQYLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGEQILKGVLEGAPRILPALRVLSGLLSS-C
SD---------------SIPLYSFCREARLPGLLLHLLRHSQENNSIQQQCWYGAFVRDL
VAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDESEQALRRDSLMC
FTVLCEAMDGNSWTISK-------AFYSSLLTTHRAVLDGLLHGLTVPQLPF--HSPP--
-GAPQVSQPLREQSEDLPGAISSALAAMCTTPVGLPGCWEAKEQISQHLADQLTKDSNHL
RSSLISALQHPILCLPLLKVLYSCCHVSERLCRLLGQEPLA-LDSLLKLAQGKVKV----
VDR--EESIEVTLYLLSLLVLRLQDLPSGMEKLGS-----EIATVFTHSHIVSL--VS-A
AACLLGQLGQQGVTLDLQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQ--QEKGNP---IRDVASSEMWTVLWHRFFMALRLPEEASTQE-EVSL-SSPQ---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLRHLSQRGSILMSTLKHLLSPSFLNHLG
QASQ-----GSEFLPIVVLSVCQL----LCFPFALDVDADLLEGVLADLTDSEVTAHLLQ
VCCHHLPLTQVELPISLLTRLALSGPAFLNQFVNTVAASPRTTISFLSTALLGDQPLLTS
DLLSLLAHTARLLSPSHLSFIHELLAGSDESYRPLRSLLSHPETSVRARTSGLLGHLLQH
SMALRGALQSQAGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLEDPQAGIRRNAVSALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLG-----NQLLPHS--SPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSNLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILRQACKRMAEEAKQKEDQNA----GSTLEQEDR--
----LSKVTPSIAPMPGL------KATPQESSLLAGILASEMKNNWEDWGAGEAPPTSR-
ENHITLECEQAFLELRPEA-------M--GRRSTDVVDPENE---EPDSDDEWQRLLETT
EPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPALRILSSLLSS-C
SD---------------SVLLYSFCQEAGLPELPLRLLRYSQESSSIQQQPWYGAFLRDL
VAVVQAYFSCTFNLERSQTGN--SLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMC
FSALCEAVDGNSRAISK-------AFYSSLLSTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVAALFTHSHVVSL--VN-A
AACLLGQLGQQGVTFDLQPREWIAAAA--HALSAPAEVRLTPPCSCGFYDG-LLILLLQL
LTQV-QGKPGL---VRDVAGSEVWTILWHRFSMALRLPEEVSAQEDDLSL-SSPS---SL
EPDWTLISPQGMAALLSLAMTIFTQES--QLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPVVVLSVCKL----LCFPFALDVDADLLVGVLADLRASEVAVCLLQ
VCCHHLSLLQAELPLGLLTRLALTDPTSLKQFVNTVATSSRAIFSFLSVVLLSDQPLMIS
DLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQDGTRRNAASALGNLGPE--GLG-KELLKCQVPQRLLEMACGDPQPTVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLSLGNQLLPN------SS-NRPASIRHCRKLI
HLLRPTHST-

------------------------------------------------------------

PF00069 // ENSGT00910000144066_2_Domain_0 (61, 277)

RAEQELRSLRREMEVMRGLRHPNIVRMLDSFETEQEVVVVTEYAEGELFQILEDDGSLPE
EQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLGKDGVIKLCDFGFARAMSIHTMVLTS
IKGTPLYMSPELVEEKPYDHTADLWSVGCILYELFVGTPPFYTSSIFQLVSLIVKDPVKW
PEAISPVFKSFLQGLLMKDPRQRLSWPELLSHP--FIA-GRVTVIDDTEEHGISNPFTTK
LPPELQALKEQQAHSLAPRSGQSRILRKARQKMAEEAQKKDSGKG---------------
NAGHKPRAAPGKAALGDGEQTAASKE------KNSAVL--QGKSSVAQRQLEEPPPSPW-
EHSITHDYEQEFGRAGVPPHAAAGRAQPHGRRSIEAVDLESE---ELESDEEWQHLIEAT
EPSATQLSTPLSLLRDTAFRHRLRARFAASAQQVLEGMLEGASHLRPVLRVVGNLLAA-C
CDAVLRVVGNLLATRCHAELLEQLCLELNVPLALLQLTKQILQSGRTKQQPWCIAVLTDI
VRVTAVYFSSACSLEESGQKD--SLQAFQESASHFLALLLDLLAEPADSEMRLCQQSLLC
FTLLCESLDATCPSVSA-------PFYTSLREEHQPLLDRLLQGSLSEHHAL-----P--
-GAAMEAKPAHDQSQRVADLYTAALAAACSIPLARNSSRDAKKQVARRVAAKLTDGENRQ
LGRLLGRLEHPGCSLNVLKILYAACHASPSLCQHLGRSQQA-WGCLLQLSQGKVPM----
AEAAQGVSCEASLYLLALLTLQPQACPPSPGGVSF-----PCSLFFRLEEVLSLAVDVGA
AAFLLAQLSQRGVDVVLREEEVLPAVT--NALTARRLLQLPPPLGAGLYDG-LIFLLLKL
LAQ---EDRAV---EQGFAASELWSVLWHGVAAVLRVGAEP---EGEAPG-AHRP---TA
QPDWNLLSPQGTLLFLSLALFIFTRES--HRCLPQLTQSHSVLMVTLRSLLSPAFLACLA
QTQAGE-DGDTELVPAVVIQACQL----LCFPFALDVDGDTLASVVAAVRDSQLPAQLLQ
ACCHHLPLPAAELPVSLLCHLVVSDERVVAQVVQQAAAS-EPILAFL--VLFSDSLPLLT
DLLSLLTHVARV-SSEHLPFLQSILGGSDASHQPLTRLLGHREPPIRAKTCSL-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PSTISPCFKNFLQGLLTKDPQKRLSWPDLLHHP--FIA-GRVTIITEPVGLDLAAPFTSC
LPAELQVLKDEQAHWLAPKGNQSRILHQAYKHMAEEAKPKKQQNR----GPALEQEDK--
----TNKMTPSTAPILEP------RATLEKSSMLAGILASEMKSSCVEWQAGEAPSALR-
ENRITPDCEQAFPELGPEV-------MS--QKS-----TDGEDE-EPDSDSEWQRLLETT
EPVPVQLKAPLTLLCNPDFCQCIQSQLHEAAGQILKGVLEGTTHILPAFRVLSSLLSS-C
RD---------------SVPLYSFCREAGLPGLPLSLLRHSQESNTIQQQPWYGAFLRDL
VAVIQAYFACTFNLERNQTGD--SLQVFQESANLFLDLLGKLLAQPDNSEHTLQRDSLMC
FVVLCEAMDGNSRAISK-------AFYTSLLTTQHAVLDGLLHGLTVPQIPF--HPPP--
-GTPRMSQALQDQNEDLPGAISCALAAICTAPVGLPSCWDAKEQVSCHLANQLTEDSSQL
RPSLISGLQHPFLCLHLLKVLYSCCHVSERLCHLLGQESLA-LESLLILVQGKVKV----
VDW--EESTEVALYLLSLLVFRLQDLPSRMEKLGS-----EVASLFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPREWIAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTEV-QGKATL---IRDVASSEMWTILWRRFSMALKLPDKVSTQEEDLSL-SSPP---SP
EPDWTLISPQGMAALLSLAIATFTQEP--PLCLSHLSERGSILMSTLKYLLSPSFLYHLS
QAPH-----GPEFLPVVALSVCQL----FCFPFSLDVDAEHLVGILADLRDAEVAALLLQ
VCCHHLPLSQVQLPISLLTHLALMDPTSLNQFVNTVAASPRTIISFLSVALLSDQPLLTS
DLLSLLAHTVRVLSPSHLFFIQELLAGSDESYRPLRILLGHSENSVRTRTYGLLGHLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPTVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQAGIRCNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDSQPNVKEAA
LIALRTLQQEPCIHQVLVSLGASEKLALLALGNQLQP-------ESSSRPASVRHCRKLI
RLLKPAHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 166)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
EQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKDGGIKLCDFG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELKNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKEEQAHRLAPKGNQSCILRRACKRMAEEAKQKKHQNT----GSALEQEDG--
----TSKVAPGIGPLPRL------RATPQESSLLAGILASEMKSSWAEWGTGEAPPAPW-
ENRITSDCEQAFPELRPEM-------V--SQRNIDTVDLEHE---EPDSDDEWQHLLETT
EPVSIQLKAPLTLLCNPDFCQRIQSQLHESGGQILKGILEGASHILPALRVLSSLLCS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSIQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDYEQTLRRDSLMC
FTVLCEAMDGNSLAISK-------AFYSSLLTTQRVVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSHPLREQSEDLPGAISSALAAICTAPVGLPGCWEAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCHVSERLCCLLGQESLA-LESLLMLVQGKVKV----
VDW--EESAEVTLYLLSLLIFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLGQQGVTFELQPMEWIAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTQ--QGKSNL---IRDVANSEMWTILWHRFSMALRLPKEVSAQEEELLL-SSTP---SS
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSYLSQRGSILMSILKHLLCPSFLHQLD
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLAGILADLRDSEVTAHLLQ
VCCYHLPLPQVELPISLLAHLALMDPTSLKQFVNTVVASPRSIISFLSVALLSDQPMLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARIYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPVVRRSASFAVGNAAYQAGP---LGPALTAAVPS
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLSVGNQLLP-------HSSPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GHVTIITESAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAESGTGEVPSAPR-
ENRTTPDCERAFPEERPEV-------L--GQRSTDVVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTND--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLA-LESLFMLIQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDMCSSEMWTVLWHRFSMVLRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCEVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSL-----PH--SSPRPASAKHCRKLI
HLLRPAHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GHVTIITEPAGLDLGTPFTSR
LPLELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAESGTGEAPSAPR-
ENQTTPDCEPAFPEERPEV-------L--GQRSTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLL-----------QLHEAGGQILKGILEGASHILPAFRVLNSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTSP--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQICWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCHLLGQEPLA-LESLFMLVQGEVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGVWG------------------MVPY--SS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QEKASL---IRDVASSEMWTVLWHRFSVVLRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTREP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALMDPTSLNEFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSRLSFIQELLAGSDESYRPLRSLLDHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRSSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLEDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSL-----PH--SSPGPASAKHCRKLI
HLLRPAHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAKV-VALKFIPKLG
RSEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTSDLWSMGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PSTISPCFKNFLQGLLTKEPQKRLSWPDLLHHP--FIA-GRVTIITEPADSDLGTPFTSR
LPPELQVLKDEQAHQLPPKGSQSRILHQAYKCMAEEAKQKKQQNI----GLALEQEDK--
----TNKMTPSTVPTPEL------RGTLEKSSLLAGILASEMKSSCAEWQAGEAPSAPR-
ENCITPDCEQAFLELGPEV-------M--SQQSTDAGDLEDK---EPNHNSEWQRLLETT
EPIPVQLKTPLALLCNPDFCQYIQSQLREAGGQILKGILEGATHILPALRVLSSLLSS-C
RD---------------SVPLYSFCREAGLPALPLSLLRHSQESNTIQQQPWYGTFLRDL
VAVIQAYFACTFNLERNQTGD--SLQVFQEAVNLFLDLLGKLLAQPDDSEHTLQRDSLVC
FVVLCEAMDGNSRAISK-------AFYSSLLTTQRAVLDGLLHGLTVSQIPF--HTPP--
-ETPSMSQALREQNEDLPGAISCALAAMCTAPVGLSSCWDAKEQVSWHLANQLTEDSSQL
RSSLISGLQHPILCLHLLKVLYSCCHVNECLCRLLGEESLA-LESMLMLVQGKVKV----
VDW--EESTEVALYLLSLLVFRLQDLPSRMEKLGS-----EVATLFTHSHIVSL--VS-A
AACLLGQLGQRGVTFDLQPREWIAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKANL---IREVATSEMWTILWHRFSMVLKLPDKVFTQEEDLSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSHLSQRGSILMSTLKYLLSPSFLYHLS
QAPS-----GPEFLPVVALSVCQL----FCFPFSLDVDADHLVGIVADLKNAEVAALLLQ
VCCHHLPLSQVQLPISLLTHLALMDSTSLNQFVDTVAASPRTIISFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLFFIQELLAGSDESYQPLRILLGHSENSVRARTYGLLGHLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPTVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDSQPNVKEAA
LIALRTLQQEPCIHQVLVSLGASEKLALLALGNQLLP-------ESNSRPASARHCRKLI
HLLKPAHST-

--------------------MEQYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 269)

VLEMIGEGSFGRVYKGRRKYTTKI-VALKFIPKVG
RSQKELKNLQREIEIMRGLHHPNIVQMLDSFETDKEVVVVTDYAEGELFQILEDDGNLPE
EQVQIIASQLVSALYYLHSHRILHRDMKPQNILLGKGGVIKLCDFGFARAMSIHTMVLTS
IKGTPLYMSPELVEEKPYDHTADLWSVGCILYELYVGTPPFYTNSIFQLVSLIIKDPVKW
PKNMSLHFKSFLQGLLMKNPHERLSWPELLYHP--FIA-GKVTVIDDTVDQGIVNPFTSK
LPPDLQALKEQQAHSLTPPSGQSKILRKARQKMAQEARRKEMGKP----KASLKGEVSKE
SET-----YSRKACLAQT---DSSRQHQKLPGMEEHL---ALGEKETEWEQKEPSSKL-Q
ENWITQDYEREFQEMKPESC----RIKTRGRRSIDTVDLETE---EMDSDEEWQHFIDAT
NSTHVHLSAPLSLLGDPAFVQRIRVRLKDSGQQVLEGMLEGASHLRPALHVISNLLGT-C
CD---------------SDLLCSFCNDIGLPQFLMQLVESILKSFNIKQQPWHITLLTDL
MAVMTVFFASDFNREKDGKKQ--SLQAFQSSANHFLTLLPALLAQPTDQEGRLREQSLVC
FTHLCQSMDNACPSISI-------PFYTSLLENHCPLLDTLCHGVSCEQIIQ--EVPP--
----KEARSKQHWNELMGAAFAKALAASCVIPGRHTVCQKAKKKISQYIAEKLTEKENRL
LASLILAVNHPASSLHGLKVLYACGHVSQTLCHHLATPEM--LNSLICHLQGKVLL----
DEAAQVQTAEASLRLFSLLMLQLQFLPSQSDIVLN-----ETMKLFNSGATASV--LS-A
AALLLTYFIQHGAAVKLRWEEALTAIA--TAFTESAEPCLPPPMGVGFYDG-LLILLLHV
LSE---GDVAM---VREFAASELWGIVWHLFAMVLHMTTQEPMLEGETSG-AGQH---AP
EPDWDLISPQGTPFFLSLTLFVFTCEP--HQCLLQMAQPNGLIMAVLNKLLDPDFLECLA
QMQLHE-DGDLELVTTTVLQVCQV----FCFAFAMDMDPEILEQILTNMKGSEIPAQLLQ
VCIHHLPCTKTELPLSLLCRLVLSDEEIIEQVVGAATS--QDAIDFLSSIFLSDQVHLLA
DLLTLLTHIARA-SPSHLPFLEKLLSGSTS--QALSHLLGHSECLVRARTCSLVGNLLRH
GQEFPHILQGQVGLLKSLLERLSDEDRHVRRSASFAVGNAAYQAGP---FMQDLRKA

PF02985 // ENSGT00910000144066_2_Domain_3 (1318, 1343)

VPC
VVRLLGDPQAKTRCNAASALGNLGWQSVELG-DSLIQNKAPNILLDVACHDSQPAVQKAA
LIALRSMSHQPRIRQVLVSLRACEKLEALTLDQF------QNSAYSHPWPSSTQHCKKLI
QLLQPSQSA-

--------------------MEK

PF07714 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLAWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GRVTII-EPAGPDLGTPFTSR
LPPELQVIKDQQAHQLAPKGNRSRILRQACKRMAEEAKKKKHQNT----GPALEQEDR--
----TSKVASGTAPLPRL------WNTPQEPGLLAGIMASETKSSWAEWGAGEAPPIPR-
ENRVTQDCERAFPELRPEA-------A--GQRSIDAVDLENE---EPDSDDEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGAQILKGMLEGASHILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSIQQQCWYGTFLRNL
MAVIQAYFACTFNLERNQTGD--SLQVFQEAANLFLDLLGKFLAQPDDSEQTLRRDSLLX
XXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX--
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXISRHLANQLTEDNNQL
RPSLISGLQHPTLCLHLLKVLYSCCHVSERLCRLLGREPQA-LESLLMLVQGKVKV----
VDS--EESTEVTLYLLSLLVLQLQDLPSGMEKLGN-----EIATVFTRSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLVLLLQL
LTQ--QVKGSL---IRDLASSEMWTALWHRFSMALRLPEEVPTQEEELLL-SSPQ---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSHLSQRGSILMSTLKHLLSPSFLHQLG
QAPH-----GSEFLPVVVLSVCQI----LCFPFALDVDADLLVGVLADLTDSEVAAHLLQ
VCCHHLPLPQAELPISLLTRLALTNPISLNQFVNTVAASPRTIISFLSVALLGDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSD

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPENSVRARTYGLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1268)

SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPG
MTQLLGDPQAGIRCNAVSALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLSLG-----NQLLPHS--SPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPARPDLGNPFTSH
LPPELQVLKDEQAHRLAPKGNQSRILTQAYTCMAEEARQKKHQNT----GPALKQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSSAESGTGEAPHVPG-
ENRTTPDCEQAFPEERPEV-------L--GQRGIDAVDPKNE---EPDSDNEWQHLLETT
EPVSIQLKAPLTLLRNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSRLLSS-C
CD---------------SVALYSFCREAGMPGLLLNLLRHSQESNSLQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAASLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSRPLREQSEDLPGAIASALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPFLISGLQHPILCLHLLKVLYSCCLVSERLCHLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVALYFLSLLVFRLQNLPCGMEKLGN-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPTEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QEKASL---IRDVASSEMWTILWHRFSMALRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMVAFTQEP--QLYLSYLSQHGSILLSILKHLLRPSFLNQLH
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVNADLLMGVSADLRDSEVPAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASSRTIVSFLSVALLSDQPLLIS
DLLSLLAHTIRVLSPSHLSFIQELLAGSDESYRPLRSLLVHPENSVRAHTYRLLGHLLQD
SMALRGALQSQTGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LRSALAAAVPS
MTQLLGDPQAGIRRNVASAFGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLAMLSLGNQSLP-------HSSPGPASAKHCRKLI
HLLRPAYSM-

--------------------MDK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RTEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
EQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLIRKDPVRW
PPSISPCFKNFLQGLLTKDPQQRLSWPDLLHHP--FIA-GRVTIITEPAGSDLATPFTSR
LPPELQVLKDEQAHQLAPKGSQSCILHQACKRMAEEAKQKKQQNT----GPALEQEDK--
----SNSMIPSTAPKVEV------RATPEKSSVLAGVLTSEMKSSCAECQAGETPTAPR-
ENCITRDSEQALPQLEPEV-------A--SQQSTDAGDVEDE---EPDSDSKWQHLLETT
KPIPVQLKAPLILLCNPDFYQCIQSQLHETGGQILKGVLEGATRILPALRVLSSLLSS-C
SD---------------SVLLYSFCREAGLPGLLLSLLRHSQESITIQQQPWCGTFSRDL
VAVIQAYFACTFNLERNQTGD--SLQVFQEAASLFLDLLGKLLVQPDDSEH-LQRDSLMC
FVVLCEAMDGNSQATSK-------AFYSSLLTTQRAVLDGLLRGLTAPQFPF--HTPP--
-GALHVNQPLREQSEDLPRAISCALAAMCTAPVGLPSCWDAKEQVSWHLANQLAEDSSQL
WPSLISGLRHPVLCLHLLKVLYSCCHVNEHLCSLLGQESLA-LQSLLMLVQGKVKV----
VDW--EESTEVALYLLSLLAFRLQDLPSRMEKLGS-----EVAMLFTHSHIVSL--VI-A
AACLLGQLGQQGVTFDLQPKEWIAAAT--HALSAPTEVRLTLPGGCGFYDG-LLILLLQL
LTK--QGKAGL---IHDVASSEILTVLWHRFSMVLKLPDKVSTQEEDLSL-SGPP---SP
EPDWTLISPQGMAVLLSLAMATFTQEP--QLCLSHLSKRRSDLMSTLKYLLSPSFLHHLS
QAPH-----GPEFLPVVALSVCQL----FCFPFSLDVDADHLVGILADLRDAEVAALVLQ
VCCHHLPPSQVELPISLLTRLALMDSTCLNQFVSTVAASPEN-ISFLSVALLSDQPLLTS
DLLSLLAHAARVLSPSHLFFIQELLAGSDESYRPLRILLGHPENSVRARAFGLLGYLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

KLLLLGLGDQDPAVRRNASFAVGNAAYQAGP---LGPALAAAVPN
MAQLLEDAQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQQPCIHEVLVSLGASEKLALLALGNQLLV-------QNSSGLASARHCKKLI
RLLKPPDST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-IALKFIPKLG
RSEKELRNLQREIEIMRGLQHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPARPYLGNPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEARQKKHQNT----GPALEQEDK--
----TSTVAPGTAPLPRL------GTTPQESSLLAGILTSEMKSSWAESGTGAVPHAPG-
ENLTTPDCEQAFPEKRPEV-------L--GQRGIDAVDLENE---EPDSGNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCQEAGMPGLLLSLLRLSQESNSLQQQCWYGTFLQDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLQEQSEDLPGAIASALAAICTAPVGQPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFMLVQGKVKV----
VDW--EESTEVALYFLSLLVFRLQNLPCGMEKLGN-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPTEWMVAAT--HALSAPAEVRLTPPGSCGFYDS-LLILLLQL
LTE--QGKASL---IRDVASSEMWTILWHRFSMALRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLATVAFTQEP--QLCLSYLAQHGSILMSILKHLLRPSFLNQLH
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVNANLLMGVLADLRDSEVPAHLLQ
VCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVAASSRTIIPFLSVALLSDQTLLIS
DLLSLLAHTVRVLSPSHLSFIQELLAGSDESYWPLRSLLGHPENSVRAHTYRLLGHLLQD
SMALRGALQSQTGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQQQSTFNVQKRHGCRA------------------------------
----------

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 235)

VLEMIGEGSFGRVYKGRRKYSAQVRVALKFIPKVG
RSEKELKNLQREIEIMRGLHHPNIVQMLDSFETDKEVVVVTDYAEGELFQILEDDGNLPE
DQVQDIASQLVSALYYLHSHRILHRDMKPQNILLGKGGLIKLCDFGFARAMSINTMVLTS
IKGTPLYMAPELVQEKPYDHTADLWSVGCILYELFVGTPPFYTNSIFQLVSLIIKDPIKW
PKTMSPLFKSFLQGLYTPGPASRVPRGGLCLETPPGLTSPIPAVMDDAEQHGVANAFTSK
LPPELQELKEKQALSLAPRSSQSQLLLRRPEQLKADAPSKKEAAR----GGQ----GR--
----THTAAAGKAALREGEQTARALGSPRGDK-IQAVLG--EEPNETEWEKTEPPPTPRQ
PS---------------------------GRGSRQPVLWDLPEE-EVDSDEEWQHLIEAT
DPSTMQLSTPLSLLGDLAFVQRIRARLQDSSQQVLEGMLEGASHLRPALRVVGNLLATRC
-D---------------SELLCRFCQATDLPAFLLRLAGQILESTSSMQQPWCTTLLADL
VGVTTAYFTSDSHRGRSWRSW----AVLSPP-GLT-CLLAGFLPP---CCPSMRTRAFLS
PAFPCCGPRGRCRAIGQTLSFVRNLWLCSFVHAW------AQRGSTAPPSAILGSSPPAG
ESAPLLAPPLQHSTPYHCGRVGG---------SAIVTLLADFPQVAQQVAEELTVENSQL
LARLLAGLERPACSLHALKVLYSCGHSSKSLCHLLAKGQQV-PSSLARLVKGEVPM----
AERLRVQACEASLHLLALLALQLQSVPPWLDLVVS-----DATEIFTQSPVVSL--VISM
GKVLLAQLGQHGAAIEVGCEEAMSAMA--NALTAPAELHLPPPMGAGLYDG-LLLLLLQL
LTQ---GDAVL---VRGFAGSELWNIAWHRVAMVLRLAADKPGMEGETPR-SGQP---AP
EPDWTLISPRGTALFLSLALAVFTREP--HQCLPQLAHPHSVVMATFNQLLSLDFLAQLA
HTQVGE-DGDPELVPAVVLQTCQL----LCFPFSLDVDTETQMWVMKALRDAETPAHLLQ
VCCHHLPFSETALPMSLLCHLVLSDEQVVDQLVGAAAASDRA-ISFLSAVLLSDSPALTM
DLLSLLTHVAPA-CPAHLPFLHMVLAGSDSAYQLLSHLLCHQEHSIRAKACSLVGNLLRQ
GQDFPRALQSQAGLLERLLERLSDQDEHVRKSASFAVGNAAYQAGS---LPHALGKAVPR
LGRLLSDPQAKTRCHAASALGNLGRQAADLG-DVLIQNRAPHLLLATACHDPQPAVREGA
PIGPAMH----PRPQVLVSLKASEKLLALSRNDA------QSRSCGSPRPSSAHHCKKLI
HLLRPTHSA-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELKNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPQQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKEEQVHRLAPKGSQSCILRRACKRMAQEAKQKKHQNT----GLALEQEDG--
----TSKVAPGTGPLPRL------RATPQEPSLLAGILASEMKSSWAEWGTGEAPAAPW-
ENRITSDCEQAFPELRPEV-------V--GQRSIDAVDLEHE---EPDSDDEWQHLLETT
EPVSIQLKAPLTLLCNPDFCQRIQSQLHQYGGQILKGILEGASHILPALRVLSSLLCS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSIQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDYEQTLRRDSLMC
FTVLCEAMDGNSQAIAK-------AFYSSLLTTQRVVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSENLPGAISSALAAICTAPVGLPGCWEAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCHVSERLCCLLGQESLA-LESLLMLVQGKVKV----
VDW--EESAEVTLYLLSLLIFRLQDLPSRMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLGQQGVTFELQPMEWIAAAT--HALSAPAEIRLTPPGSCGFYDG-LLILLLQL
LTQ--QGKANL---IRDVANSEMWTILWHRFSMALRLPKEVSAQEEELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSYLSQRGSILMSILKHLLCPSFLHQLD
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLVGILADLRDSEVTAHLLQ
VCCYHLPLPQVELPISLLARLALMDPTSLKQFVNTVVASPRTIISFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARIYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPVVRRSASFAVGNAAYQAGP---LGPALTAAVPS
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLSLGNQLLP-------HSSPRPASAKHCRKLI
HLLRPTHSV-

--------------------MEK

PF07714 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLDLIGEGSFGRVYKGRRKHSGEV-VALKFIPKVG
RSEKELKGLKREIQIMRDLRHPNIVRMLDSCETEREVVVVTEYAEGELFKILEDDGHFPE
ELVRDISAQLVSALYYLHSHRILHRDMKPQNILLSKDGTVKLCDFGFARELSLDTLMVRS
IKGTPLYMSPELILERPYDHRSDLWALGCIVYELLVGTPPFYAHSIFQLVSIITQQAVRW
PRGVSPELTNFLQGLLTKDPAVRLSWPELLRHP--FIK-DQVVVVEEN---ANNSPFTSP
LTEEQQQLRNQLCENAGQSSVHSRILSKARQRVAKRKEKPVVCNLHVQIPPPLCEAHRKQ
PEN------GQQAPAPRI------SEQPRQ-KKLTKILSSSLHAHFAH--------AHFR
EHRISEDYDREFSLEKS------------VRGSIQKVRLENEVSFPQDSDDEWAVMLEAT
DPSVAQISTPFLLLQDSSFRQRVKSRLQDCCPLV---SLEAASRLRPALRVTCNLLTSGC
-D---------------PALLSDLCTELQLPQFLLKVINQSLHT-DLKQHPWAVSFLTDL
FALLNSYYHFKRHPES--------SSSLQACEGLFLGVLDFLLSGPQEGDTTLQELGLQC
LVSLCESADCSPVPECE-------KVYNMLQSEHKGLLDKIIARSQ----------PPIA
KISAGVTEPDYSAGERLAGFYTEALASLCDIPPSG-EHRRLKENVSLYVSEKLLSDMGCL
FDSFVTSLQHSHCTLSRLKVLYCCCHVSLDLCKRLVSNSCA-LQCIISLLEGEVSA----
WDASMIHTAGQALFLMSLLVLRLQSLPPQLPPLLFFFNSKQITIIFSHSRMSRM--TLLL
LRLLTCDLPSVVVSFPRGPFTILAPQAPTVTIFAPGQVSSTA-LTCAIQDCGVPIAL---
-S---QDNLEE---ALSLAVSEEGAFLWHRLSVLLQVSHQRPRLEGDTPRE----N-ECS
KPDWNLLSVRGIVSFLELSLLTSVRDP--DRFLSLLAHPDSIAMAAVNRLLTPSFLAHVS
EACNSCGWDESDTISEIVILVCQL----LCIPFSVETPTEALREILQSLREHQTVTLLLK
TCC-HLPQSLAELPVSLVCRLVLMEPDFLAEFSQAVTSS-DDLAIWLGNALHSGQDSLTC
DLLSVFSHLIRV-SSSHLPLLQRIVGDWEE---LLSWLLQASESGLRAAACTLAGNLARL
G

PF02985 // ENSGT00910000144066_2_Domain_2 (1262, 1304)

ETLPQ------SFVKRLLDCLSDRDARVRRSAAFAMGNTAFH

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

GAKGNIY

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1347)

NPWVSTAASK
FLTLLRDPQSKTRAHAASALGNLGSVLGEGGQTSPLMLKVPQLLLQSACTDQEQTVRLAS
VIALRSLSETPNVRQHLKSLNAGEKLSSSLSSESE------HRSPRSGTVPWAHHCEKLL
HLLRAPEFS-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPASPGLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILHQAYKHMAEEAKQKKHQNT----GSALEQENG--
----TSKVVPGTGPLPRL------RATPQEPSLLSGILASEMKNSWAEWGTGEAPSAPW-
ENRIASDCERTFPELRPEV-------V--SQQSIDIADLENE---EPDSDDEWQHLLETT
EPLPIQLKAPLTLLCNPDFCQRIQSQLHESGGQILKGILESASHILPAFRVLSSLLCS-C
SD---------------SVPLYSFCREAGLPGLLLNLLGHSQENSSLQQQSWYGTYLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDFLGKLLAQPDDYEQTLRKDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQQIVLDGLLHGLTVPQLPF--HTPP--
-GASQVNQPLREQSEDLPGAISSALAAICTAPVGLPGCWEAKEQVCWHLANQLTEDSSHL
RPSLISGLRHPILCLHLLKVLYSCCHVSERLCCLLGQQPLA-LESLLMLIQGKVNV----
VDW--EECTEVTLYLLSLLVFRLQDLPSGVEKLGS-----EVATLFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWIAAVT--HALSAPAEVRLTPPSSCGFYDG-LLILLLQL
LTQ--QENPNL---IRHLANSEMWTILWHRFFMTLRLPKEVSAQEEELSL-SSPP---SP
EPDWTLISPQGVAALLSLAMATFTQEP--QLCLSYLSQHGSILLSILKHLLCPSFLHQLD
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADFLVRIVADLRDSEVTVHLLQ
VCCYHLPLSQVELPISLLARLALMDPTSLKQFVNTVVASPRAIISFLSVALLSDQPLLIS
DLLSLLAHIARVLSPSYVSFIRELLTGSDESYRPLRSLLGHPENSVRARTYRLLGHLLQH
SMALRRALQSQSG

PF02985 // ENSGT00910000144066_2_Domain_2 (1274, 1299)

LFNLLLQGLGDKDPAVRRSASFAVG

ENSGT00910000144066_2_Linker_2_3 (1299, 1318)

NAAYQAGP---LGPALIAA

PF02985 // ENSGT00910000144066_2_Domain_3 (1318, 1344)

VPR
ITQLLEDPHAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEIACGDPQPNVKEAA
LIALRSLQREPCIHQVLVSLGASEKLALLSLENQLLP-------HSSHRPASVKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILTQAYKRMAEEAIQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPW-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSN-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAIDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPECWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCRHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AAHLLGQLGQQGVTFNLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEVWTVLWHRFSMVLRLTKEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLRPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRNSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIISFLSVALLSDQPLLTS
DLLSLLAHTARVLSSSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SVALRGALQNQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPSIHQVLVSLGASEKLALLSLGNQSL-----PH--SSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 268)

VLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPQQRLSWPDLLYHP--FIA-GRVTIITEPAAPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILRQACKRMAEEAKQKNQQNA----EPALDQEDG--
----TSKVAPGTTSPPRL------RATLQEPGLLAGILASEMKNNWAEWEA---PPAPR-
EHQIIQDCERTFPELRPEM-------V--GQGSIDTVDLENEPQ-DPDSDDEWQNLLDTV
EPVPIQLKTPLTLLCNPDFCQRIQSQLQEAGGQILKGILEGASLILPALRVLSSLLSS-C
SD---------------YVPLYSFCREAGLPGLLLSLLKHSQESNSIQQQSWYGAFLRDL
MAVIQAYFACTFNLERSQTND--SLQVFQEAANLFLDLLGKLLAQADDSEQTLRRDSLMC
FTVLCEAMDGNSQANSK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQNEDLPGAISSALAAMCTAPVGLPGCWEAKEQVSRHLAYQLTEDSNQL
RPSIISGLQHPILCLHLLKVLYSCCYVSESLCRLLGQEPLA-LESLLMLVQGKVKV----
VDW--EESTEVTLYLLSLLVLRLQELPSGMEKLGS-----EIAALFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDFQPTEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLHL
LTQ--QGKASL---IRDVASSEMWTILWHRFSMALRLPEEVSTQEEELSS-SSPQ---SS
EPDWTLISPQGMAALLSLAVVTFTQEP--QLCLSHLSQHGSILMSTLKHLLSPRFLHLLG
QAPH-----GSEFLPAVVLSVCQL----LCFPFALDVDADLLVGILADLRDSEVAAHLLQ
VCCHHLLLPQVELPISLLTHLGLTDPTSLSQFVSTVAASPSTSISFLSVALLGDQPLLTS
DLLTLLAHTARVLSPSHLSFIQELLAGSDESYRPLRCLLGHPENCVRARTYGLLGHLLQH
SMALRGALQSQPGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLEDPQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLALG-----NQLLPHSGSGPRPASAKHCRKLI
YLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSTQV-VALKFIPKLG
RSEKELKNLQREIEIMRGLRHPNIVHLLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGVKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCLKNFLQGLLTKDPRQRLSWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GRVTIVTEPASIDLGTPFTSR
LPPELQVLKEEQAHRLAPKGGQSRILRQAYKRMAEEAKQKKHQNT----GPAPVPEDR--
----ISQGAPDPAPLPKL------RGPPQEVSLLAGILASE-KNSWAEWGPGEAPTVQC-
ENQSSSVGEPGLAELKPAV-------S---QHNIDATNSGNE---EPDSDEEWQHLLETL
EPVPIQLKAPLTLLCNPDFCQHIQSQLHEAGGQILKGSPEGASHILPALRVLSCLLSS-C
RE---------------SAPLYSFCREAGLPGLLLSLLKHSQETNSIQKQPWYGAFLRDL
MAVIQAYFACTFNLDRSQTGD--SLQVFQEAANVFLDLLGKLLAQPDDSEQSLRRDSLMC
FTTLCETMDGNSQAISK-------AFYSSLLSTQRVVLDGLLHGFTVPQLPF--HSPP--
--APQVSQPLRDQSEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVSWHVATQLIEDSSKL
RPSLISGLQHPVLCLSLLKVLYACCHVSERLCHLLGQEPLA-LESLLLLVQGKVNA----
VDQ--EESTEVALYLLALLVFQLQDLPCGMEKLGS-----EVTPVFTRSHVVSL--VS-A
AACLLGQLGQHGMAFELQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LIILLLQL
LTQS--GKASX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXPH-----GPEFLPVVVLSVCQL----FCFPFALDVDASLLVGILADLRDSEVAAHLLQ
VCCQHLPLSQAELPISLLTRLALTDLTSLNQFVNAVAACPRTVPSFLSAALLSDQALLSS
DLLSLLAHTARVQSPSHPSFIQELLAGSE

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPENLVRARTYRLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1268)

SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

VQSQAGLLNLLLLGLGDQDPAVRRDASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPS
LTQLLGDPQASIRRNAASALGNLGPE--GLG-EELLQYQAPQRLLETACGDPQASVKEAA
LIALRSLRQEPSIHQVLVSLGASEKLALLSLGNQLLP-------HGSPRPTSARHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHNADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PTTISPCFKSFLQGLLTKDPTQRLSWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GRVTIITEPGGPDLGTPFTSR
LPPELQVLKDQQVHRLAPKGNRSRILRQACKRMAEEAKQKKHQNT----GPALEQEDR--
----TSKMASGTTPLPRL------RATPQEPGLLAGILASEMKSSWAEWGAGEAPPAPR-
ENLVTQDCERVIPELRPEV-------V--GQRSIDAVDLENE---EPDSDDEWQHLLETA
EPAPIQLKAPLTLLCNPDFCQRIQGQLHEAGGQILKGMLEGGSHILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSIQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQMFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSWTVSK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAMSSALAAICTAPVGLPSCWEAKEQISQHLANQLTEDNNQL
RPSLISGLQHPVLCLHLLKVLYSCCHVSEHLCHLLGQEPLA-LESLLMLVQGKVKV----
VDW--EESTEVALYVLSLLVLRLQDLPSGMDKLGN-----EIATLFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIAAAS--HALSAPAEVRLTPPGGCGFYDG-LLILLLHL
VTQ--PGKGSL---IRDVASSEMWTVLWHRFSMALRLPKEVSAQEEEPSL-SRPQ---SP
EPDWTLISPQGVAALLSLAVATFTQEP--QLCLSHLSQHGSILMSTLKHLLSPSFLHQLG
RAPH-----GSEFLPLVVLSVCQL----FCFPFALDVDDDLLGGVLADLGDSEVAAHLLQ
VCCHHLPLPQVELPVSLLTRLALTDPTSLNQFVNAVAASPRTVISFLSVALLGDQPLLTS
DLLSLLAHTARVLSPNHLSFIQELLAGSD

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPENSVRARTYGLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1268)

SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLSLLLLGLGDKEPAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPG
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-AELLQCQVPQRLLDMACGDPQLNVKEAA
LIALRSLRQEPCIHQVLVSLGASERLAMLSLG-----NQLLEPS--SPRPASARHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GHVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMKKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASGMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
ESVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLNLL---VILLTPGITVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSMVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
HAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLSLLLLGLGDKDPIVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAG

PF13513 // ENSGT00910000144066_2_Domain_4 (1332, 1387)

IRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAT
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

------------------------------------------------------------
------------------------------------

PF00069 // ENSGT00910000144066_2_Domain_0 (97, 277)

VVVVTDYAEGELFQILEDDGKLPE
NQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFELVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPQQRLSWPDLLHHS--FIA-GHVTIITEPAALGLGTPFTSR
LPPELQVLKDQQAHRLAPRGNGLRVLRQARKRMAEEAKQKNHQKT----APALEQEDK--
---------TSKVALPRL------RTTPQEPSLLAGILASEMQSNWAEWGPGDAPSTPW-
EPQITADQEQAFPEPRPEVV---------DQKTMDAVDLENE---EPDSDKEWQHLLEST
KPLPTQLKAPLSLLCNPDFCQRVQKQLQEAGGQVLKGIPEGAAHLLPVLQVLINLLTS-C
SD---------------SQVLYSFCREAGLPELLLNLFKHSQENPGIPQQSWYGAFLREL
LTAIQAYFACTFNLERGQTSDXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXC
LTVLCETMDGNSQAITN-------AFYSSLLTTQRAVLDGLLHGLTLPQLPF--HTPP--
-GAPQVSQSLREQSEDLPGAISSALAAICTAPVGLPGCWEAKEQISRYLASQLTENGSQL
RPSLISGLQHPILCLHLLKXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXVKV----
ADW--EESVEVTLYLLSLLVLRLQALPSGLERLGS-----ETAALFTHSHVVSL--GN-A
AACLMEQLCHQGVTLDLQPVEWMAAAT--HALSAPAEVRLAPPGGSGFYDG-LLILLLQL
LTQ--QGKTSL---IRDLVHSEMWTVLWHRFSMALRLPKEVSMQEDELLL-PHPQ---SP
VPDWTLISPQGMAALLSLAVATFTQEP--QLCLSHLSQHGSILMSTLTHLLSDSFLQQLA
RAXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
VCCHHLLLPQVELPMSLLTRLALTEPTSLSQFVNAVASSPSTFTSFFSDALLGDQPLLTS
DLLSLLAHAARVLTPSHVSFVQELLAGSDESYRPLRSLLGHPRNSVRTRIYGLLGHLLQH
SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDPAVRRNASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GSALAAAVPS
LTQLLGDPQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLSLGNQFVS-----PNSSSPRPASAKHCRKLI
HLLRPSHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 166)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 268)

VLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GHVTIITETAGPDLGTPFTSR
LPPELQVLKDKQAHRLSPKGNQSRILTQAYERMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAESGTGEAPSAPR-
ENRTTPDCERAFPEERPEV-------L--GQRSTDAVDLEDE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTKQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDGKEQVCWHLANQLTEDSSQL
RPSLVSGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFMLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDMSSSEMWTVLWHRFSMVLRLPKEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFAQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIISFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYQSLRSLLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIRQVLVSLGASEKLALLSLGNQLL-----PH--SSPRPASAKHCRKLI
HLLRPAHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSESGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILRQACKRMAEEAKQKKHHNT----ESALEQEDR--
----NNKVTPSTVPLPGL------RATPKESNLLAGILASEMKNSWAEWGAGEAPPTPR-
ENHITPGCEQAFPELRSEV-------V--GQRSIDAVDLENE---EPESDDEWQQLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLREIGGQILKGTLENASHILPALRVLSSLLSS-C
SD---------------SDPLYSFCQEAGLPELLLSLLRHSQESNIIQQQPWYGAFLRDL
MAVIQAYFACAFNLERSQTGD--SLQVFQEAANIFLDLLGKLLSQSDYSEQTLRRDSLMC
FTVLCETMDGNSRAISK-------VFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAIASALAAICTAPVGLPGCWEAKEQVSWHLANQLTEDSSQL
RPSLISGLRHPILCLHLLKVLYSCCHISERLCHILGKEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVSFDLQPREWITAAA--HALSAPAEVRLTPPDSCGFYDG-LLILLLQL
LTQVQQGKTSL---IRDVASSEMWTILWHRFSMALRLPEEVGTQEEELSL-SNPS---IP
EPDWTLISPQGIAALLSLAMATFTQEP--QLCLNHLSQRGSLLMSTLKHLLSPSFLHHLS
QAPH-----GAEFLPVVAVSVCQL----LCFPFALDVDADLLVGILADLRDSEVAANLLQ
VCCHYLPLSQVELPISLLTRLALTDPTALNQFVNTVAASPRAIIPFLSVVLLSDLPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARTYGLLGHLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1384)

NLLLLGLGDEDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNAVSALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQLNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLP-------HSSPRPASARHCRKLI
HLLRPTHNT-

-------------------------------------------------V

PF00069 // ENSGT00910000144066_2_Domain_0 (51, 277)

VALKFIPKLG
RTEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDY-----------------
--VQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLIRKDPVRW
PPSISPCFKNFLQGLLTKDPQQRLSWPDLLHHP--FIA-GRVTIITEPAGSDSATPFTSR
LPPELQVLKDEQAHQLAPKGSQSCILHQACKRMAEEAKQKVLNPK---------------
---------PHKS---RI-----------------RLMA-----------------SSGR
ENCITRDSEQALPQLEPEVA---------SQQSTDAGDVEDE---EPDSDSKWQHLLETT
EPIPVQLKAPLILLCNPDFYQCIQ------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------TMDGNSQATSK-------AFYSSLLTTQRAVLDGLLRGLTAPQFPF--HTPP--
-GALHVNQPLREQSEDLPRAISCALAAMCTAPVGLPSCWDAKEQ----------------
-------------------VLYSCCHVNEHLCSLLGQESLA-LQSLLMLVQGKVKV----
VDW--EESTEVALYLLSLLXFRLQDLPSRMEKLGS-----EVAMLFTHSHIVSLVVSF--
---------QSSLSFLLPPVI--HAFRGHTLKTKMSKVRLTLPGGCGFYDG-LLILLLQL
LTKVQW-KAGL---I---------------------------------------------
------HDVASMAVLLSLAMATFTQEP--QLCLSHLSKRRSDLMSTLKYLLSPSFLHHLS
QAPH-----GPEFLPVVALSVCHGELSLFLNPFYLH-----------------PCSPCSQ
VCCHHLPPSQVELPISLLTRLALMDSTCLNQFVSTVAASPEN-ISFLSIALLSDQPLLTS
DLLSLLAHAARVLSPSHLFFIQELLAGSDESYRPLRILLGHPENSVRARAFGLLGYLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

KLLLLGLGDQDPAVRRNASFAVGNAAYQAGP---LGPALAAAVPN
MAQLLEDAQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQQPCIHEVLVSLGASEKLALLALGNQLLV-------QNSSGLASARHCKKLI
RLLKPPDST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGVKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTMSPCFKSFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTILTEPAGPDPATPFTSR
LPPDLQILKEQQARQLAPAGTRSRILRQARKHMAEELEPREERRA----DPSPGHEDK--
----AGQGPPDTAPPARP------QLPAQEPGLVPVALPSEARSSWAEWGAGEAPPAPR-
XXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX-X
XX---------------XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXX-XXXX--XXXX--
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXISQYVAEQLTEDGSLL
RASLISGLQHPVLCLPLLKXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX----
XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXX--XX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXVQLTPPGGCGFYDG-LLVLLLQL
LSQXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXX-XXXXX-XXX
XXXXXXXXXXXMATLLSMAMSAFSQKP--QLCMNHLSKRESLLMTTQEHLLSPGFLQQLV
QAHR-----GAEFLPILVLSTCQL----LCFPFALDVDAELLEGILTDLTAAHVATHLLQ
ACCHHLPLAQVELPISLLSRLALMDLASLHQFVEAVTASPQASLAFLSTALLSDQPLLAA
DLLSLLAHTARVLPPAHLSFVQELLAGPEESYGPLRSLLGHAETPVRARTYGLLGHLLQH
SRALRGALQSQAGLLSLLLLGLRDKDPAVRRVAGFAVGNATYXXXX---XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX--XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXVLVSLGASEKLSLLALGPHFLP-------PSEPRPASAKHCRKLI
HLLRPAHRT-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKPQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSYGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSMVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPGFLNQLR
HAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQXXXXXXXXXXXXXYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLISLILKDPVRW
PPTISPCFKNFLQGLLTKDPQQRLSWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GRVTILTEPGGPDLGTPFTSR
LPPELQVLKDQQAHRLAPKGNRSRILRQACKRMAEEAKQKKQQNT----GPPLEQEDG--
----TNKVASGTSPLPRP------KTTPQKPGLLAGILTSEMKSSWAEWGAGEAPPAPR-
ENWIIQDCEQALPELRPEV-------V--GRRSLDAVDLENE---EPDSDDEWQHLLEAT
EPAPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGVLEGASRILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSLQQQYWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDMLGKLLTQPDDSEQTLRRDSLVC
FTVLCEAMDGNSQAISK-------AFYSSLLMTXXXXXXGLFGTLEDPT-----ATPP--
-GAPQVSQPLREQSEDLPGAISLALAAICTAPVGLPGCWEAKEQISRHLANQLTEDSSPL
RSSLVSGLKHPILCLPLLKVLYSCCHVSECLCRLLGQEPLA-LESLLKLVQGKTKV----
VDW--EESTEVTLYLLSLLVLRLQDLPSGMEKLGS-----EVATVFTHSPVVSL--VS-A
AACLLGQLGQQGVTVDLQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQ--QGKDNP---VRDVAGSEMWTVLWHRFSMALRLPEEASTQEEELSL-SSPQ---SL
EPDWTLISPQGTAALLSLAVATFTQEP--QLCLSHLSQRGSILMSTLKHLLSPSFLHQLG
QAPQ-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLEGILADLTDSEVTAHLLQ
VCCHHLSLTQVELPVSLLTHLALTDPTSLKQFVNTVAASPRTTISFLSVALLGDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSD

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPENSVRARTYGLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1268)

SLALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPR
MTQLLGD-QAGIRRNAASALGNLGRE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALFSLGNQLLP-------HNSPRPASTKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPARPDLGNPFTSR
LPPELQVLKDKQAHRLAPKGNQSRILTQAYKRMAEEARQKKHQNT----GPALEQEDK--
----TSKVASGTAPLPRL------GATPQESSLLAGILASEIKSSWAESGTGEAPHAPG-
ENRTTPDWEQAFPEEKPEV-------L--GQRGIDAVDLENE---EPDSDNEWQHLLETT
EPVSIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYPFCREAGMPGLLLSLLRHSHESNSLQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTFLCEAMDGNSQAVSK-------AFYSSLLTTQQAVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGATASALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPVLCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFMLVQGKVKV----
VDW--EESTEVALYFLSLLVFRLQNLPCGMEKLGN-----DIATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPTEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDVASSEMWTILWHRFFMALRLPEEASAQEGELSL-SSPP---SS
EPDWTLISPQGMAALLSLAMVAFTQEP--QLCLSYLSQHGSILMSILKHLLHPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLMGVLADLRDSEVPAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASSRTIVSFLSVALLSDQPLLIS
DLLSLLAHTVRVLSPSRLSFIQELLAGSDESFRPLHSLLGHPENSVRAHTYRLLGHLLQD
SMALRGALQSQTGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYRAGP---LGPALAAAVPS
MTQLLGDPQAGIRCNVASALGNLGPE--GLG-EELLQCQAPQRLLEVACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSMGASEKLALLSLGNQSLP-------HSGPRPASAKHCRKLI
HLLRPAYSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRHRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSR
LPPELQVLKDEQVHRLAPKGNQSRILRQACKHMAEKAKQKKKQNA----GPALEPEER--
----LSKVTLGSAPVPEL------KASPQESSLLASILDSEMKSNWEDWVAGEAPPTPR-
EDHITLECEQVFPELRPET-------M--GQQNTDAMDLENE---EPDSDDEWQRFLETT
EPVPVHLKAPLTLLCNPDFCQRIQSQLRGTAEQILKGILEDASHLLPALRVLSSLLSS-C
SD---------------SVLLYSFCQEAGLPRLPLSLLRHSQESSSIQKQPWYRAFLRDL
VAVVQAYFSCTFNLERSQTGD--SLQVFQEASNLFLELLGKLLTQSDDSEQTFRRDSLMC
FAVLCEAVDGNSQAISN-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQCEDIPGAISSALAALCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLVSGLRHHILCLHLLKVLYSCCYISEHLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLSQQGVIFDLQPQEWISAAA--HALSAPAEVRLTPPCSCGFYDG-LLILLLQL
LTQV-QGKPGL---IRDVAASEVWTILWHRFSMALRLPEEVTVQEDDLSL-SSPP---SL
EPDWTLISPQGMSALLSLAMAIFTQEP--QLCLTHLSQHGSILMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPVVVLSVCQL----LCFPFALDVDADLLVGILADLRDSEVAVYLLQ
VCCHHLPLLQAELPIGLLTRLALMDSTSLKQFVDTVATSSRTIISFLSIALLSDQPRMIS
DLLSLLTHTARVLSPSHLSFIQELLSGSDESYRPLRNLLGHSENTVRVRTYRLLGHLLQH
SMALRGALQSQAGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQDGIRRNAASALGNLGPE--GLG-KELLQCQVPQRLLDMACGDPQPAVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLPN------SG-TRPASARHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TRKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHFLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSTVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
HAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

MQQSLISSSSSRLRDPGALMMEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 269)

VLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSDKELRNLHREIEIMRGLRHPNIIQMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISQCFKSFLQGLLTKDPRQRLSWPELLYHP--FIA-GRVTMTSETVTSDLGTPFTSR
LPLELQALKEEQTNWLTPKGGQSRILRQARKRMAEDTRQKTHLNP----GTSLEQVEK--
----ASKAVPVAALLPRL------GATSQDLDFLSRTPSPEDKKDWAEWEASEPPQPTR-
EPQVTQEYDQEFPELKQEA-------EESSV-------GTLEPE-EPDSDSEWQHLLEPT
APSDIQLKAPLTLLCNPDFCQRVQNQLHGAGGQVLEGILDGASRLLPTLRVVKSLLTT-C
SD---------------SALLYAFCREAGLPGLLLNLLRHSQSSVNIQQQPWCGTFLRDL
VATIQAYFAGNFNLEKSQTSD--SLHVFQEAANLFLNLLGKLLAQPDDAEQTLRRDSLMC
FTDLCKTMDGSNLAISK-------SFYCSFLTTHKPVLDGLLHGMALPQLPL--HTPP--
-GAPQVSQPLREQDEDLPRAFATALAAICTLPVGLPGCWEAKEQVSKHLADQLTDDSSQL
RPYLFSSLQHPSLSLHLLKVLYACCHVNENLCRRLDQEPLA-LESLLLLVQGKVDV----
IDP--EETAEATLHLLSLLVLRLQVLPPGVKKIGN-----ELAVLFVHSPVVSL--VS-A
AAGLLSQLSQQGVAFNLQPKEWIAAAA--HALSAPAELRRTPPGGSGFYDG-LLFLLLHL
ITQ---GGAEI---VQDVANSELWTILWHRFFMTLRLSEEVPTSEDKMSL-PSQ---SVP
EPEWTLISPQGITALLNVALAVFTQEP--HLCLPYLIQHNSILMSTLKHLLSPIFLQQLG
QTQH-----GSELLPAVVLPVCQL----LCFPFAMDVDVDVLLNILADLRDSEVPAHLLQ
VCCRYLLLPQAELPVSLLARLALTDSTTLNQFVASVAASPNT-ITFLSAALLGDQPLLTS
DILSLLAHAARAWPPTHLPFLQDLLAGPDESYWPLRCLLGHPENPVRARAYGLLGHLLHQ
STALRGALQSQAG

PF02985 // ENSGT00910000144066_2_Domain_2 (1274, 1299)

LLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGP---LAPALVPAVPR
VTQLLGDPQTGTRRNAASALGNLGPE--GLG-EELLRCQVPHRLLETACGDPQPTVREAA
LIALRSLRQEPSIHQVLVSLDASEKLASLSSASPLPPH----SSSGSPRPSSARHCKKLI
HLLRPAHST-

--------------------MER

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEVIGEGSFGRVYKGRRRCSAQV-VALKFIPKVG
RSEKELKNLQREIEIMRGLHHPNIIQMLDSFETDKEVVMVTDYAEGELFQILEDDGSLPE
DQVQTIAAQLVSALYYLHSHRILHRDMKPQNILLGKDGVIKLCDFGFARAMSIHTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELFMGTPPFYTSSIFQLVSLIVKDPVKW
PKAISPAFKSFLQGLLMKDPHQRLSWPELLSHP--FVA-GRVTVIDDTEEHGISNPFTTK
LSPELQALKEQQAHSLAPRSGQSRILRKARQKMAEEAQKKGQLKA----NITSVKDSGKG
HTRHKPRAAFGKAALE-----EEVELPPSFKEKKSGVLQ--GKNSMAEWQLKEPPPSPR-
EHSITQDYEREFPQPEAPLQLAVGKAELRGRQSIKAVDLESE---EQESDEEWQHLIEAT
EPLAMQLSTPLSLLRDPAFRHRVQARLAESAQQVLEGMLEGASHLRPVLRVVGNLLATRC
-D---------------SELLNLFCQELSLPLSLLHLAKQMLESGSTRQQPWCITVLTDL
IMVTTVYFSSECNLEKSGQ---DSLQTIQESANHFLALLPDLLAEPADSEMRLCQQSLLC
FTLLCESLDAMCPSISA-------PFYASLREENEPLLDRLLQGLISEQPALQ-------
-GATMEAKSAHDQRQCVADLCTAALAAACSIPLAQSSCRETKQQVAQEIAGKLMDGECQQ
LGKLLGRLEHPNCSLNVLKILYTCCYASPSLCQHLGRSQQV-WDFLMQLSKGKVPM----
AEVTRKVACEASLYLLALLTLQPQASPSRLEEVVT-----LALDVLTQSPVISV--VG-A
AAFLLTQLDQRGVPVALQGKEILPAVT--NALMEPAELHFSLPMGAGLYDG-IIFLLLKL
LAQ---EDVAV---EQSFAASELWNVVWHCVPAVLCMGSSGAALEGDSPG-AGPP---VA
EPDWSLLSPQGTLLFLSLALLIFTRET--HRCLPQLTQSRGVFMVMLKTLLSPRFLACLA
QTQAGE-NGEAELIPAVVIQACQL----LCFPFALDVDEDTIALVIEAVRDSQIPPQLLQ
VCCHHLPFSDTELPMSLLCRLVVSDEQVTDQIAREAATS-EHIIAYLSTVLFSGSLTLTT
DLLSLLTHVART-CPEHLPFLQRILGGSDMSYQALTHLLSHQEHPIRAKTCNLLGNLLRH
SHGFPQVLQNQPGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

ESLLVCLADEDEAVRKAASFAVGNAAYHESS---PAGTLGRAVPR
LTQLLSDRQAKTRCNAASALGNLGRRSAELG-ELLIESGAPRILLEMACRDPQASVREGA
LMALRAVSQHPGIQQVLLSLRATDQLAALAGGDSWTT------AGGSPRPSSARHCQKLI
RLLTPLQST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GHVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNA----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQQGTDAVDLENE---EPDSDNEWQHLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSTVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
HAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVQCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTILTEPAGPDFGTPFTSR
LPPELQVLKDQQAHRLAPKGNRSHILRQACKRMAEEAKQKKHQNT----EPPLEQEDR--
----TSKVAPGTAPLPKL------KDTPQEPGLLTGVVASEMKSSWAEWGAGEAPPAPR-
ENWITQDCEQVFPELRPEV-------K--GQQSLDAVDLENE---EQDSDDEWQYLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGEQILKGALEGAPCILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLKHSQESNSIQQQCWYGAFVQDL
VAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDSEQALRRDILMC
FTVLCEAMDGNSWTVSK-------AFYSSLLTTHRAVLDGLLYGLTAPQLPF--HSPP--
-GAPQVSQPLREQSEDLPGAISSVLAAMCTAPVGLPGCWEAKEQIAQHLADQLTKDSNHL
RSSLISALQHPILCLPLLKVLYSCCHVSERLCHLLGQEPLA-LESLLNLAQGKVKV----
VDR--EESTEVTLYLLSLLVLRLQDLPCGMEKLGS-----EIATVFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPGEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQVQQGKGNP---IRDMASSEMWTVLWHRFFMALRLPEEASTQEEEVSL-SSPQ---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSHLSQRGSILMSTLKHLLSPSFLHHLG
QAPQ-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLEGVLADLTDSEVTAHLLQ
VCCHHLPLTQVELPISLLTRLALSDPAFLNQFVNTVVASPRTTVSFLSTALLGDQPLLTS
DLLSLLAHTARLLSPSHLSFIHELLAGSDESYRPLRSLLSHPETSVRARTYGLLGHLLQH
SMALRGALQSQAGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLEDPQAGIRRNAVSALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLG-----NQLLPHS--SPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GHVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAKSGTGEVPSAPR-
ENRTTPDCERAFPEERPEV-------L--GQRSTDVVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPQ--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLA-LESLFMLIQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCEVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSL-----PH--SSPRPASAKHCRKLI
HLLRPAHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSH
LPPELQVLKDEQAHRLAPKGNQSRILRQAYKRMAEEAKQKKHQNT----GPTLEQEDR--
----TSLVAPVTAPLPKL------RATPQEASLLTGILASEMRSSWTEWGFGEDPPPSR-
ENQIT-HCKQALPELRPEV-------L--DQPSIDAVDRENE---EPDSDEEWQHLLEIA
APVPIQLKAPLTLLCNPGFCQRIQNQLHETGEQILKGILEGASNILPALRVLSSLLSS-C
SD---------------SAPLYSFCQEAGLPGLLLNLLRHSQENNSIQQKSWYGTFLRDL
VAVIRAYFACTFNLERNQTGD--SLQVFQEAANLFLDLLGKLLVQPDGSDQTLQRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTRCVVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQNEDLPEAISSALAAICTAPVGLPGCWEAKEQVSWHLANLLTEDSNQL
RPFLISGLQHPILCLHLLKVLYSCCHVNERLCHLLGQEPLA-LESLLMLVQGKVKV----
VDW--EECTEVTLYLFSLLVFRLQDLPCGMEKLGN-----EVAALFTHSHIVSL--VS-A
AACLLAQLSQQGVTFDLQSMEWMAAAT--HALSAPAEVRLIPPGNYGFYDG-LLILLLQL
LTQ--QGKTDL---IRNVASSEMWTILWHRFSMALRLPEEVSAQEEEQSL-SSTP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSYLSQRGSILMSILKHLLCPSFLHQLD
QAPH-----GSEFLPVMVLSVCQL----LCFPFAMDVDVDLLIGITTNLSDSEVAAHLLQ
VCCHHLQLLQVELPISLLTRLALTDSTSLNQFVNTVAASPRAVISFLSIALLSDQPLLSS
DLLSLLAHTARTLSPSHFSFVQDLLAGSDESYRPLRSLLGHPENSVRARTYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPVVRRSASFAVGNAAYQAGP---LGPALAAVVPS
MTQLLGDPQPGIRRNAASALGNLGPE--GLG-EELVQCQVPQRLLDTACGDPHPNVKEAA
IIALRSLQQEPCIHQVLVSLGASEKLALLSLGNQLML-------HSSPRPASAKHCRKLI
HLLRPTHST-

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 270)

VLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELKNLQREMEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIVTEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILRQAYKRMAEAAKQKKHQST----GRAPEQEDR--
----TSQAAADTAPLPRP------RGTPQEASLLAGILASEMKSSWAEWGPGEAPPAPR-
ENRSTADGGQGFAEPRPEA-------V--SPRSISAVKPENE---EPDSDEEWQHLLETL
EPVPIQLKAPLTLLCNPDFCQHIQTQLHASGAQILKGSLEGASHILPALRVLSSLLSS-C
SD---------------SAPLYSFCREAGLPGLLLSLLRHSQESSSIQTQPWYGAFVRDL
MAAMQAYFACTFNLDRSQTGD--SLQVFQEAASLFLDLLGKLLAQPDDSEQSLRRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQRVVLDGLLHGLTMPQLPF--HTPP--
-GAPQASQPLRDLSEDLPGAVSSALAAVCTAPVGLPSCWEAKEQVSWHLATQLIEDSSQL
RPSLVSGLQHPILCLSLLKVLYSCCHVSERLCRLLGQEPLA-LESLSLVVQGKVKA----
ADQ--EESTEVALYLLALLVFRLQDLPCGMEKLGG-----EVATLFTHSHVVSV--VS-A
AACLLGQLGQQGVAFELQPAEWMAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILVLQL
LTQ--QGKARL---IRDVAGSELWTILWHRFSMALRLPEEVPTLEEELLL-SVPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSHLSQRGNILMSTLKHLLSPNFLHHLG
QAPH-----GPEFLPVVVLSVCQL----LCFPFSLDVDADLLVGILADLRDSEVAAHLLQ
VCCHRLPLSQAELPISLLTRLALTDLTSLNQFVNAVSASPRTVTSFLSASLLGDQPLLTS
DLLSLLAHAARALAPSHLSFIQELLAGSDESYRPLCSLLGHPENLVRARTYGLLGHLFRH
SMALRGALQSQAG

PF02985 // ENSGT00910000144066_2_Domain_2 (1274, 1299)

LFNLLLQGLGDKDPAVRRSASFAVG

ENSGT00910000144066_2_Linker_2_3 (1299, 1318)

NAAYQAGP---LGPALAAA

PF02985 // ENSGT00910000144066_2_Domain_3 (1318, 1344)

VPS
LTQLLGDPQTGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEVACGDPQPSVKEAA
LIALRSLRQEPCIHQVLVSLRASDKLALLSLGNQLP--------HSSARPASARHCRKLI
QLLRPTHDT-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLDKGGGI------FARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTMSPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPARPNLGNPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAAEARQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWAESGTGEAPHAPG-
ENRTTPDWEQAFPEERPEV-------L--GQRGIDAVDLENE---EPDSDNEWQHLLETT
EPVSIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SAALYSFCREAGMPGLLLSLLRYSQESNSLQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQQVVLDGLLHGLTVLQLPV--HTPP--
-GAPQVSRPLREQSEDLPGATASALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPTLCLHLLKVLYSCCLVSDRLCRLLGQEPLA-LESLFMLVQGKVKV----
VDW--EESTEVALYFLSLLVFRLQNLPCGMEKLGN-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDVASSEMWTILWRRFSMALRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMVTFTQEP--QLCLSYLSQHGSILMSILKHLLHPSFLNQLR
QAPH-----GSEFLPVVVLAVCQL----LCFPFALDVDADLLMGVLADLRDSEVPAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASSRTIVSFLSVALLSDQPLLIS
DLLSLLAHTVRVLSPSHLSFIQELLAGSDESYRPLRSLLGHSENSVRAHTYRLLGHLLQD
SMALRGALQSQTGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPSLAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
DLLRPAYSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSR
LPPELQVLKDEQAHRLAPKGSQSRILRQACKLMAEEAKQKEDQNA----GSALEQEDR--
----LSKVTPSTAPVPGL------KATPQESSLLAGILASEVKNNWEDWGAGEAPRASR-
ENHINLECEQGFPEPRPEV-------M--GRQSTDVVDPENE---EPDSDDEWQRLLETS
EPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGILDGVSHLLPVLRILSSLLSS-C
SD---------------SVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDL
VAVVQAYFSCTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMC
FSVLCEAVDGNSWAISK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLGQQGVTFDLQPREWIAAAA--HALSAPAEVRLTPPCSCGFYDG-LLILLLQL
LMQV-QGKPGL---IRDVAGSEVWTILWHRFSMALRLPEEVSAQEDDLLL-SSPS---SL
EPDWTLISPQGMAALLSLAMAIFTQES--QLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPVVVLSVCKL----LCFPFALDVDADLLVGVLADLRASEVAVCLLQ
VCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMIS
DLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQDGIRRNAASALGNLGPE--GLG-KELLKCQVPQRLLEMACGDPQPTVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLSLGNQLLPN------SSSHRPGSVRHCRKLI
HLLRPSHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVQMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISQCFKSFLQGLLTKDPHQRLAWPELLYHP--FIA-GRVTVISEPVAADLGTPFTRR
LPPELQVLKEEQAHCLAPKSGQSRILRQARKHMAEEARQKKHLNP----GVSLEQVDK--
----ASKVDPATALLPSL------RATSQDLELCSGILP-EDKNEWADWGASEPPL----
------------------------------------------PT-EPDSDSEWQRLLEPT
APSDFQLKAPLTLLCNPDFCQRIQNQLHGAGGQVLEGILDGASRLLPALRVVKSLLTT-C
SD---------------SVLLYAFCREAGLPGLLLNLLRHSQNNINIQQQPWCGAFLRDL
VATIQAYFASSFNLERSQTGD--SLQVFQEAANLFLNLLGKLLAQPDDAEQTLRRDSLMC
FTDLCKTMDGSSLTISR-------SFYSSLLTTHRTVLDGLLHGMALPQL-L--HTPP--
-GAPQVSQPLREQDEDLPRAFATALAAICTLPVGLPDCWEAKEQVSKYLADQLTEDSSQL
RPYLFSSLQHPTLSLHLLKVLYACCHVSENLCRRLDQDPLA-LESLLLLVQGKVDV----
MDP--EEAAEATLHLLFLLVLRLQVLPPGXXXXXX-----XXXXXXXXXXXXXX--XS-A
AAGLLSQLSQQGVAFNLQPKEWTAAAA--HALSAPAELRRTPPGGSGFYDG-LLFLLLQL
ITQ--QGGAQI---VQDVANSELWTILWHRFFMTLRLSEKVPTSEIEISL-SSQL---IP
EPEWTLISPQGIIALLNLALAVFTREP--HLCLPHLIQHGSILMSTLKHLLSPSFLQQLG
QTQH-----GSELLPAVVLPVCQL----LCFPFAMDVDVDILLSILADLRDSEVPAHLLQ
VCCRHLLLPQAELPVSLLTRLALTDSTTLNQFVAAVTASPNT-ITFLSAALLGDQPLLTS
DILSLLAHAARVWPPTHLLFLQDLLAGPDESYWPLRCLLGHPENPVRARAYGLLGHLLHH
STALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLSLLLAGLKDKDPAVRRNASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

APALVPAVPR
VTQLLGDPQTGTRRNAASALGNLGPE--GLG-EELLRCQVPHRLLETAXXXXXXXXXXXX
XXXXXXXXXXXXXXXVLVSLHASEKLASLSSSGP-----LPPHSSSSPRPSSARHCKKLI
HLLRPAHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PTTISPCFKSFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPGGSDLGTPFTSH
LPPELQVLKEQQVHRLAPKGNRSRILRLACKRMAEEAKRKKHQNT----GPALEQEDR--
----TSKMASGTAPLPRL------RATPQEPGLIAGILASEMKSSWAEWGAGETPPAPR-
ENQITQDCEQADPELRPEV-------V--GQQSIDAVDLENE---EPDSDDEWQHLLKTG
EPVPIQLKAPLTLLCNPDFCQRIQGQLHEAGGQILKDVPEDASHILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQESNSIQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDQLGKLLAQPDDSKQTLRRDSLMC
FTVLCEAMDGNSWTISK-------AFYSSLLTTQRAVLDGLLHGLTVPQLSF--HTPP--
-GAPQVSQPLREQSEDLPGAMSSALAAICTAPVGLPSCWEAKEQISRHLANQLSEDSNQL
RPSLISGLQHPILCLHLLKVLYSCCHISERLCHLLGQEPLA-LESLLMLVQGKVKV----
VDW--EESTEVALYLLSLLVLQLQDLPPGMEKLGN-----EIATLFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIAAAS--HALSAPAEVRLIPPGCCGFYDG-LLILLLQL
LTQ--PGKGSL---LRDVADSEIWTVLWHRFSMALRLPEEVSPQEEEPSL-SRPQ---SP
EPDWTLISPQGMAALLSLAVATFTQEP--QLCLSHLSQRGSILMSTLKHLLSPSFLRQLG
RAPQ-----GAEFLPVVVLSVCQL----LCFPFALDVDADLFRGVLADFVDSEVAAHLLQ
VCCHHLPLPQVELPVSLLTRLALTDLTSLNQFVNTVAASPRTVISFLSVALLGDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPEHSVRARTYGLLGHLLQH
SMALRGALQSQAGLLNL

PF13646 // ENSGT00910000144066_2_Domain_3 (1278, 1385)

LLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLEDPQAGIRRNAVSALGNLGPE--GLG-AELLQYQVPQRLLEMACGDPQLNVKEAA
LIALRSLRQEPCIHQADGFQGCSCYSWRCGAPSPIWATRPCGHDGGPSWPQREQST-T--
-ILASAGETA

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 271)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKDGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQQLHHPF--IAG--FIA-GRVTIITEPAGPDLGTPLTSR
LPPELQVLKDQQAHQLAPKGNRSRILRQARKLMAEEAKQKKHQNT----GPTLEQEDR--
----TIKVVTGTTPVP----------PPQEPGLLAGIMASEMKSSWAEWGAGEAPPAPR-
ENWITEDSERAFPELRPEQ-------SQAGQQSTGAVDLENE---EPDSDDEWQHLLETM
EPVPIQLKTPLTLLCNPDFCQRIQSQLHEAGGQILKDMLEGASCILPALRVLSNLLTS-C
SD---------------SVPLYVFCREAGLPGLLLRLLRHSQESHSIQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAADLFLDLLGKLLAQPDDSKQTLQRDSLMC
FTVLCEAMDGNSCAISK-------AFYSSLLTTQRAVLDGLLRGLTVPQLPF--HTPP--
-GAPQVSQPLKEQSEDLPGAISSALAAICIVPLGLPGCWEAKEQISRHLANQLTEDNNQL
RPSLICGLQHPILCLHLLKVLYSCCHVSERLCRRLGQEPLA-LKSLLMLVQGKIKV----
VDW--EESTEVTLYLLSLLVLRLQDLPSGMEKLGS-----ETATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIPAAT--HALCAPAEVRLTPPDGCGFYDG-LLTLLLQL
LTQ--EGKANL---IRDMVSSEMWTVLWHRFSMALRLSKEVSTQEEELTL-SSPHS-SSS
EPDWTLISPQGVAAMLSLAVATFTQEP--QLCLSHLSQHGSILMSTLKHLLSPSFLQQLG
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLGGILANLTDSAVTAHLLQ
VCCHHLLLPQVELPISLLTHLALRDPTSLNQFVNTVAASPGTIISFLSVALLGDQPLLTS
DLLSLLAHTARVLPPSHLSFIQELLAGSDESYRPLRSLLGHPENCVRARIYGLLGHLLQH
SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLSLLLLGLGDKDPAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPC
MTQLLGDPQAGIRRHAVSALGNLGSE--GLG-EELLQCQVPQRLLEMACGDPQPHVKEAA
LIALRSLSQEPCIHQVLVSLGASEKLALLSLGNQLLP-------HSSPRPASAKLCMKLI
HLLRPAHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVC-FDNYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAIQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAESGTGEVPSAPRR
ENRTTPDCERAFPEERPEV-------L--GQQSTDVVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSEHLCRLLGQEPLA-LESLFMLIQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGVSPQKS--------------SIWGM--VP-Y
TACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLC
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRCNVASALGNLGPE--GLG-EELLQCEVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPAHSM-

----------------------------------------------AQV

PF07714 // ENSGT00910000144066_2_Domain_0 (50, 166)

-VALKFIPKLG
RSPKDLRNLQREIEIMQGLRHPNIIHLLDSFETDREVRIVHSVREGLLIVVL-----IPT
LQVRVIAAQLVSALFYLHSHRILHRDVKPQNILLAKDGGVKLCDFG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVNLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GCVTIITEPAGSDLGTPFTNR
LPPELQVLKDEQAHRLAPKGNQSRLLHQAYKRMAEEAKQKKQQNT----GPALEQEDK--
----TNKMAPSTAPKLEL------RTTPEKSSLLAGIVASEMKSSCAERRSVEAPPAPR-
ENCITPDCEQAFPELGPEV-------VS--PQSTDTGDLE--DE-EPDSDSEWQHLLETT
EPVPIHLKAPLTLLCNPDFCQCIQSQLRETGGQLLKGILEGATHILPALRVLSSLLSS-C
SD---------------SVPLYSFCQEAGLPGLLLSLLRHSQESNTFQQQPWCGTFLRDL
VAVIQAYFACTFNLEKNQTGD--SLHVFQEAANLFLDLLGKLLAQPDDSEHTLQRDSLMC
FTVLCEAMDGNSQAISK-------AFYSSLLTTQHAVLDGLLRGLTASRFPF--HPPA--
-GAPHMNEPLWEQSEELPGAISCALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RSSLILGLRHPVLCLHLLKVLYSCCRVSEHLCCLLGQEPLA-LESLLILVQGKVKV----
VDW--EESTEVALYLLSLLVFRLQDLPSRMEKLGG-----EVATLFTHSHIVSL--VS-A
AACLLGQLGQQGVTYDLQHSEWIAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTQV-QGKASL---IRDVASSEMWTILWHRFSMTLKLPDKVSTQEENLSL-SSPP---SS
EPEWTLISPQGMAALLSVAMATFTQEP--QLCLSHLSQRGSILMSTLKYLLSPSFLYHLS
QAPH-----GPEFLPVMVLSVCQL----FCFPFSLDVDADHLVGILAHLRDAEVAALLLQ
VCCHHLPLSQVELPISLLTRLALMDITSVNQFVSTVAASSKAI-IFLSAALLSDQPLLTS
DLLSLLAHTARVLSPSHLFFIQELLAGSDESYQPLRILLGHPENSVRARTYGLLGHLLQH
SMALRGALQSQTGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

KLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPN
MTQLLGDAQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLALGNQLLP-------QNSSRPASARLCRKLI
RLLKPAQST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTVPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEETPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRVQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAIDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPECWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQDPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFNLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSMVLRLTKEASTQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLRPSFLNQLC
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDANLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SVALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSL-----PH--SSPRPASAKHCRKLI
HLLRPTHSM-

-------------------------------------------------V

PF00069 // ENSGT00910000144066_2_Domain_0 (51, 277)

VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PATISPCFKNFLQGLLTKDPQQRLSWPDLLHHP--FIA-GRVTIITEPAVPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQFRILRQACKRMAEEAKQKKQQNT----EPALDQEDG--
----ISKVASGTALLPNL------RATLQEPDLLAGIVASEMKNSWAELGTGEASPTLW-
EHRVTLDCEPAFPEQRPEVV---------GQRSIDGVDLENEXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXILKGILGGVSLILPVLRVLGSLLSS-C
SD---------------YVPLYSFCREVGLPGLLLSLLRHSQESKSLQQQSWYAAFLRD-
MAVIQAYFACTFNLERSQTND--SLQVFQEAANLFLDLLGKLLAQTDDSEQTLRRDSLMX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XX--
--X-XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXVLYSCCCVSERLCRLLGQEPLA-LESLLKLVQGKVKV----
ADW--EESTEVTLYLLSLLVLRLQDLPSGMXXXXXXXXXXXXXXXXXXXXXXXX--XX--
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVRPTPPGGCGFYDS-LLILLLQL
FTQ--QGKASL---IRDVASSEMWAILWHRFSMALRLPEEVSTQEEQLSP-SSLQ---SP
EPDWTLISPQGMAALLSLAVATFTEEP--QLCLSHFSQHGSILMSTLKHLLSPGFLHQLG
QAPH-----GSEFLPAVVLSVCQL----FCFPFALDLDADLLVGFLADLRNSEVATYLLQ
VCCHHLLLPQVELPISLLTHLALTDPTSLSQFVSTVTASPSTVISFLSVALLGDQPLLTS
DLLTLLAHTARVLSPSHSSFIQELLAGADESYRPLRCLLGHPENCVRARTYGLLGHLLQH
SLALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPS
MTQLLEDPQAGIRRNAASALGNLGPE--GIG-EELLECQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIH-VLVSLGASEKLALLSLGNQLLS------SGSGPRPASAKHCRKLI
YLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHP--FIA-GHVTIITESAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASELKSSWAESGTGEVPSAPR-
ENRTTPDCERAFPEERPEV-------L--GQRSTDVVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTND--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSEGLCCLLGQEPLA-LESLFMLIQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDMCSSEMWTVLWHRFSMVLRLPEEASAQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIGVLADLRDSEVAAHLLQ
VCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCEVPQRLLEIACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSL-----PH--SSPRPASAKHCRKLI
HLLRPAHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 166)

YHVLEMIGEGSFGRVYKGRKKYSAKV-VALKFIPKLG
RSEKELRNLQREIEIMQGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

------------------------------------------------K

PF00069 // ENSGT00910000144066_2_Domain_0 (50, 277)

VVALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVQMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISQCFKSFLQGLLTKDPRQRLAWPELLYHP--FIA-GRVTVTSESVTSDLGTPFTSR
LPPELQVLKEEQAHWLAPKSGQSRILRQARKRMTEEARQKKHLNP----GLPFEQVDK--
----AGKAVPMTALLSRL------RTTSHDLNLSSGASSPEDKNEWADWVASEPPLPTR-
EPQVTQEYDQQFPELKREA-------E----ENMNAVNL--ETE-EPDSDNEWQHLLEPT
APSNFQLKAPLTLLCNPDFCQRVQNQLHGAGGQVLEGILDGASRLLPALRVVKSLLIS-C
SD---------------SSLLYAFCREAGLPGLLLNLLRHSQSSISIQQQPWCGTFLRDL
VATIQAYFASNFNLEKSQTGD--SLQVFQEAANLFLNLLGKLLAQPDDAEQTLRRDGLMC
FTDLCKTMDGSSLSISK-------SFYSSLLTTHRPVLDGLLHGMALPQLPL--HTPP--
-GAPQVSQPLREQDEDLPRAFATALAAICTLPVGLPGCWDSKEQVSRYLADQLTEEGSQL
RPYLFSSLQHPSLSLHLLKVLYACCHVSENLCRRLDQEPVA-LESLLLLVQGKVDV----
MDP--EEAAEATLHLLSLLVLRLQVLPPGVKKIGN-----ELAVLFVHSPVVSL--VS-A
AAGLLSQLSQQGVAFNLQPKEWTAAAA--HALSAPAELRRTPPGGSGFYDG-LLFLLLQL
ITQ---GGAEI---VQDVANSELWTILWHRFFMTLRLSEEVPSSEDKRNL-PSQT---IP
EPEWTLISPRGITALLNLALAVFTQEP--HLCLPHLIQHGSILMSTLKHLLSPSFLQQLG
QAPH-----GSELLPAVVLPVCQL----LCFPFAMDVDVDILLSILTDLRDSEVPANLLQ
VCCRYLLLPQAELPVSLLTRLALTDSTTLNQFVAAVAASPNT-ITFLSAALLGDQPLLTS
DILSLLAHAARVWPPTHLFFLQDLLAGPDESYWPLRCLLGHPENPVRARAYGLLGHLLHH
STALRGALQSQAG

PF02985 // ENSGT00910000144066_2_Domain_2 (1274, 1299)

LLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGP---LAAALAPAVPR
VTQLLGDPQTGTRRNAASALGNLGPE--GLG-EELLRCQVPHRLLETACGDPQPTVREAA
LIALRSLRQEPCIHQVLVSLDASEKLASLSSSGPLPP--------GSPRPSSARHCKKLI
HLLRPAHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQVIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTILTEPAGPDLGTPFTSR
LPPELQVLKDQQAHRLAPKGKRSRILRQACKRMAEEAKQKKHHNT----GPALEQEDR--
----TSKVASGTAPRPRL------KATPQEPGLLTGILASEVKSSWAEWGAGEAPPAPR-
ESWIAQDCERAFPELKPEV-------E--GQRSLDAVDLENE---EPDSDNEWQHLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGVLEGASRILPALRVLSSLLSS-C
SD---------------SLPLYSFCREAGLPGLLLSLLRRSQESTSIQQQCWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANIFLDLLGKILAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRTISK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAISLALAAICTPPVGLPDCWEAKEQVSRHLANQLTEDSNPL
RSSLISGLEHPILCLHLLKVLYSCCHVSE--------QPLA-LGSLLKLVQSKVKV----
VDW--EESTEVTLYLLSLLVLRLQDLPSGMEKLGT-----EVAPVFTHSHVVSL--VS-A
AACLLGQLGQQGVTLDLQPTEWMAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQ--PGKGDL---IRDVAGSEMWTVLWHRFAMALRLPGEASAPEEEPSL-SSPQ---SP
EPDWTLISPQGMAALLSLAVATFAQEP--QLCLSHLSERGSILMSTLKHLLSPSFLHQLG
QAPQ-----GCEFLPVVVLSVCQL----FCFPFALDVDADLLDGVLADLTASEVTAHLLQ
VCCHRLPLTQVELPISLLTRLALTDPTSLNQFVNTVAAFPRTTIPFLSVALLGDQPLLTS
DLLSLLAHTIRVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARTYGLLGHLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1384)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLGDPQAGIRRNAVSALGNLGPE--GLG-EELLHCQVPQRLLEMACGDPQPNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLP-------HSSPRPASAKHCRKLI
HLLRPSHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
EQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPGGPDSGTPFTSR
LPQELQVLKDQQAHQLAPKGSRAHILQKACKRMAEEARQKRQN-T----GITPEQEDR--
----SSKVASSTAPPPRL------RATPQEPDLLSSTLVSEAKGSWVESGAREAPPAPG-
LNHTPQDGEGAFPELRPEGV---------GQKSIEAVDLENE---EPDSDDEWQNLLETS
DPTLVQLKAPLTLLCNPDFCQRIQSQLQETGTQILKGVLEGASRILPALRVLSSLLSA-C
GD---------------SVLLYPFCREAGLPGLPLSLLKHSQEHSAIQQQCWYGTFLRDL
ISVIQAYFACTFNLERNHTGD--SLQVFQEASNLFLDLLGKLLAQPDDSEQILRRDSLMC
FTVLCETVDGNSRAISR-------AFYSSLLTTQCAVLDGLLHGLTLPQLPF--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAHVGLPACLEAKEQXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXVLYSCCHISDHLCHLLGQEPTA-MESLLMFIQGKIKV----
VDW--EESTEVTLHLLSLLVLRLQDLPSGXXXXXXXXXXXXXXXXXXXXXXXXX--XX--
-XXX--XXXXXXXXXXXXXXXXXXXXX---XXXXXXX---XXXXXXXXXXXXXXXXXXXX
XXXXXQGQGSL---IRDVVSSEMWTILWHRFSLALRLHEEVSTQAEGPSN---P---HSP
EPDWMLISPQGMAALLSLAVVTFTQEP--QLCLNHLCQRGSLLMANLKRLLAPGFLQQLG
RAPH-----GLEVFPVVVLSVCQL----LCFPFALDVDAEVLIRVLAELTDSEVSGHLLQ
ACCHHLPLPQAELPISLLTRLALSDSTSLTQFVNTVAASPKNIISFLSVALLSDQPLLTS
DVLSLLAHVARVLSPSHLTFIQELLAGTDESYRPLRSLLGHPDNCVRARMYGLLGHLLQH
SVALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQASLLSLLLLGLGDKDPAVRRSASFAVGNATYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPS
MTQLLGDPQAGTRRNAVTALGNLGPE--GLG-EQLIQCQVPQRLLEMACGDPQLNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLSLLSLGNQLPP-------HSSPRPASAKHCRKLI
RLLRPPPST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILRQACKLMAEEAKQKEDQNA----GSALEQEDR--
----LCKVTPSTAPVPGL------KATPQESSLLAGILASEMKNNWEDWGAGEAPRTSR-
ENHINLECEQGFPEPRPEA-------M--GRQSTDVVDPENE---EPDSDDEWQRLLETS
EPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSS-C
SD---------------SVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDL
VAVVQAYFSCTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMC
FSVLCEAVDGNSWAISK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLGQQGVTFDLQPREWIAAAA--HALSAPAEVRLTPPCSCGFYDG-LLILLLQL
LMQV-QGKPGL---IRDVAGSEVWTILWHRFSMALRLPEEVSAQEDDLLL-SSPS---SL
EPDWTLISPQGMAALLSLAMAIFTQES--QLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPIVVLSVCKL----LCFPFALDVDADLLVGVLADLRASEVVVCLLQ
VCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMIS
DLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQDGIRRNAAAALGNLGPE--GLG-KELLKCQVPQRLLEMACGDPQPTVKEAA
LIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPN------SS-NRPASVRHCRKLI
QLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILRQACKLMAEEAKQKEDQNA----GSALEQEDG--
----LCKVTPSTAPVPGL------KATPQESSLLAGILASEMKNNWEDWGAGEAPRTSR-
ENHINLECEQGFPEPRPEA-------M--GRQSTDVVDPENE---EPDSDDEWQRLLETS
EPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSS-C
ND---------------SVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDL
VAVVQAYFSCTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMC
FAVLCEAVDGNSWAVSK-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLGQQGVTFDLQPREWIAAAA--HALSAPAEVRLTPPYSCGFYDG-LLILLLQL
LMQV-QGKPGL---IRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLL-SSPS---SL
EPDWTLISPQGMAALLSLAMAIFTQES--QLCLSHLSQHGSVLMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPVVVLSVCKL----LCFPFALDVDADLLVGVLADLRASEVVVCLLQ
VCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMIS
DLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQH
SMALRGALQSQSGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1385)

NLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDAQDGIRRNAASALGNLGPE--GLG-KELLKCQVPQRLLEMACGDPQPTVKEAA
LIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPN------SS-NRPASVRHCRKLI
QLLRPTHST-

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 270)

VLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GHVTIITEPAGSDLGTPFTSR
LPPELQVLKDQQAHRLVPKGNQFRILRQACKRMAEELKQKRHQNT----GPALEQEDR--
----TSKVASGTASPPRL------RATPQESGLLAGILASEMKSSWAECGAGEDPPAPR-
ENWTTQDCERAFPELRPEV-------M--GQQSIDAVDLENE---EPDSDDEWKHLLETS
KPMPIQLKAPLTLLCNPDFCQRIQAQLHEAAGQILKGMLEGASQILPALRVLSSLLSS-C
SD---------------SVPLYSFCREAGLPGLLLSLLRHSQENNSIQQQCWCGTFLQDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANHFLDLLGKLLAQPDDSEQNLWRDSLMC
FIVLCEAMDGNSWTVAK-------AFYCSLLTTQRAVLDGLLHGLTVLQLPV--HSPP--
-GAPQVSQPLREQSADLPGALSSALAAICTTPVGLPGCWKAKEQITRHLANQLIEDSTQL
RPSIISGLKHPILCLHLLKILYSCCHISEHLCHLLVQEPLA-LESLLMLVRGKVKV----
VDW--EESAEVTLYLLSLLVLRLQDLPSGMEKLGG-----EIATVFTRSHVVSL--VS-A
AACLLGQLGQQGVPFDLQPVEWIAAAT--HALSAPAEVRLTPPDGCGFYDG-LFILLLQL
LSQ--EGKGSL---IREVASSEMWTVLWQRFSMALRLPEEVSAQEEELSL-CSPQ---SP
GPDWTLISPQGMAALLSLAVASFTQEP--QLCLSHLSQRGSILMSTLKHLLSPSFLHQLG
QAPH-----GSEFLPVMVLSVCQL----LCFPFALDVDADLLVGVLADLTNSEVTAHLLQ
VCCHHLPLPQVELPISLLTHLALMDSTSLNQFVNTVAASPRSMISFLSIALLGDQPLLTS
DLLSLLAHTVRVLSPSHLSFIQELLAGSDESYRPLRSW-AHPENSVRARTYGLLGHLLQH
SMALRGALQ-QTGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLSLGNPSL-----PH--SSPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GHVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHQLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERLEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQHIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSPAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLCQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSMVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
HALH-----GSEFLPVVVLSVCQL----LCFPFALDMDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYWPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEN

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKHSAQV-VALKFIPKVG
RSEKELKNLQREIEIVRDLHHPNIIQMLDSFETAKEVVVVTDYAEGELFQILEDDGSLPE
DQVQTIAAQLISALYYLHSHRILHRDMKPQNILLGKDGVVKLCDFGFARAMSIHTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELFVGTPPFYTNSIFQLVSLIIKDPVKW
PVNMSPVFKSFLQGLLMKDPHQRLSWPELLSHP--FIA-GRVIVIDDTEEHGISNPFTAK
LTPELQALKEQQVHSMTPRSSQSRILRKAQQKMVEETQKKKDSVN----GHPT-------
---HRPRAASRKAASEEREPL--AASNEKNPCLL------QGESSTAEWEFEESPPNPG-
QHSLSRDYEWESPGAGSPPQAGAGRAEPWSRHSIEAVGLESE---ELESDEEWQHLIEDT
EPSAMQLSVSLSLLRDPAFQHRVRDHLADSAQQVLEGMLEGASHLRSVLHVMGNLLSTQC
-D---------------AELLDHFCQELNVPLSLLCLAKQILKNDITKQQPWCIAVLTDI
LMVTKVYFSSECILEENGQKD-----SLQESADCFLALLPELLAVPVDSEMRLCQQSLLC
FTQICESLDTADPSVSA-------HFYTRLQEEHQPLLNRLLQGSISEQPTLRGSSGAAG
EG-----KSAHDQSPCVADLFLAALAAACSIPLERNSCREAKQQVAYTVAEKLMEGESQQ
LARLLGRLEHPGCFLNALKILYAGCHACLNLCQHLGRSQPL-WGSLMQLLKAEVPV----
VEVTQKAACDVSLYLLTLLTLQLQASSPRYEEVVT-----LAVDLISQSPVVSL--VG-A
AAFLLAQLSQHRVALELKRENILPVVT--NALTAPAELQLPLPMGSGLYDG-LFFLLLKL
LEQ---EDVVL---EEGFASSELWSLAWHCVAVVLHVGTNVAALEGHPPPGAGHP---MA
EPDWNLLSPQGTLLFLSLALSVFTRES--HQCLFQLTQSQGVLMVTLKRLLSPSFLERLE
QMQAGK-DGSPEVVPDVVIQVCQL----LSFPFALDVDKDTLALIIQAMRDTQIPAQLLQ
VCACHLPFSFTELPMGLLCQLVVSDTQIIDQVVKEAATS-EHIVAFLKSVLFSDNVILTS
DLLSLLTHVARV-CSEHLPFLQTILKDSDTVDEPVTYLLSHKQHLIRARTCNLLGNLLQH
S--FSPVLQSQPGWLERLLECLSDPESCVRRAATFAVGNAACHASC---PAGTLGSA

PF02985 // ENSGT00910000144066_2_Domain_3 (1318, 1345)

VPA
LARLLSDTQAKTRCNAALALSNLAQRGAELR-DMLIQSRAPDLLLQVTCQDPRKTVREGA
LEALHALSQHPEIQQVLLSLKATEKLAALAG--------------VSPQSPSARHCELLL
RRLSALPSQ-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGSIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTVPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEETPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPIQLKAPLTLLCNPDFCQRVQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESKSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAIDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPECWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCHLLGQDPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFNLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSMVLRLTKEASTQEGELSL-SSPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLRPSFLNQLC
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDANLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPGNSVRAHTYRLLGHLLQH
SVALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTILTEPAGPDSGTPFTSR
LPPELQALKDQQAHRLAPKGNRSHIFVLW----QPDSSDSKHQNT----GLPLEQEDR--
----TSKVAPGTAPVPKL------KDTPQEPGLLTGVVASEMKSSWAEWGAGEAPPVPR-
ENWITQDCERAFPELRLEV-------M--GQQSLDAVDLENE---EQDSDDEWQYLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGEQILKGVLEGAPRILPALRVLSGLLSS-C
SD---------------SIPLYSFCREAGLPGLLLHLLRHSQESNSIQQQCWYGAFVRDL
VAVIQAYFACTFNLERSQTGD--SLQVFQEAASLFLDLLGKLLAQPDESEQALRRDSLMC
FTVLCEAMDGNSWSISK-------AFYSSLLTTHRAVLDGLLHGLTVPQLPF--HSPP--
-GAPQVSQLLREQSEDLPGAISSALAAMCTTPVGLPGCWEAKEQISQHLADQLTKDSNHL
RSSLISALQHPILCLPLLKVLYSCCHVSERLCHLLGQEPLA-LDSLLKLAQGKVKV----
VDR--EESIEVTLYLLSLLVLRLQDLPSGMEKLGS-----EIATVFTHSHIVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIAAAT--HALSAPAEVRLTPPGGCGFYDG-LLILLLQL
LTQ--QEKGNP---IRDVASSEMWTVLWHRFFMALRLPEEASTQE-EASL-SSPQ---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLRHLSQRGSILMSTLKHLLSPSFLNHLG
QASQ-----GSEFLPIVVLSVCQL----LCFPFALDVDADLLEGVLADLTDSEVTAHLLQ
VCCHHLPLTQVELPISLLTRLALSGPAFLNQFVNTVAASPRTTISFLSTALLGDQPLLTS
DLLSLLAHTARLLSPSHLSFIHELLAGSDESYRPLRSLLSHPETSVRARTSGLLGHLLQH
SMALRGALQSQAGLL

PF13646 // ENSGT00910000144066_2_Domain_3 (1276, 1384)

NLLLLGLGDKDPAVRRGASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLEDPQAGIRRNAVSALGNLGPE--GLG-EELLQCQVPQRLLEMACGDPQPNVKEAA
LVALRSLRQEPCIHQVLVSLGASEKLALLSLG-----NQLLPHS--SPRPASAKHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSDKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
EQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNKMELTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PPTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--F

ENSGT00910000144066_2_Linker_0_1 (277, 1230)

IA-GRVTILTESAGPDLGTPFTSR
LPPELQVLKDQQAHRLAPKGNRSRILRQAYRHMAEEAKQKKHQNP----GPALEQEDR--
----TSKVASGTASLTRL------KATPQEPSLLTGVLGSEMKSSWAEWRAGEAPPAPW-
ENWITQDCEQAFPELRPEV-------V--GQQSLDAVDLENEEP--GNDDAEWRHLLETT
EPVPVQLKAPLALLCNPDFCQRIQSQLHEAGGQILKGVLEGASHILPVLRVLSSLLSSRG
GD---------------SVSLYSFCRGAGLPWLLLSLLRHSQESSSIQQQRWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLELLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSWTISR-------AFYSSLMTTQRAVLDGLLHGLTVPQLPF--HSPP--
-GAPEVSQLLREQSEDLPGALSSALAALCTAPVGLPGCWEAKAQISRHLANQLTEDSNQL
RSSLISGLQHPILCLHLLKVLYSCCHVSEPLCCLLGREPLA-LESLWKLVQGKVKV----
VDW--EESAEVALYLLSLLVLHLQDMPSGMEKLGS-----EVATVFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPVEWIAAAT--YALSAPAEVRLTPPGGCGFYDG-LLMLLLQL
LTQXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X--X---XX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXILMSTLKHLLSPSFLHHLT
QAPQ-----GPEFLPVVVLSVCQL----LCFPFALDVDADLLEGVLADLTDSEVTAHLLQ
VCCHHLPLTQAELPISLLTRLALSEPPSLNQFVSTVAACPTTTISFLSAALLGDQPLLTS
DLLSLLAHTARVLSPSHLSFIQELLAGPD

PF02985 // ENSGT00910000144066_2_Domain_1 (1230, 1261)

ESYRPLRSLLGHPENSVRARTYGLLGHLLQH

ENSGT00910000144066_2_Linker_1_2 (1261, 1269)

SGALRGAL

PF02985 // ENSGT00910000144066_2_Domain_2 (1269, 1304)

QSQLGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAVPG
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-DELVRCQVPQRLLEVACGDPQPNVKEAA
LVALRSLQQEPCIHQVLVSLGASEKLALLSLGNQLLP-------RSSPRPASTKHCRKLI
HLLRPTHNT-

--------------------MER

PF07714 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEVIGEGSFGRVYKGRRRCSAQV-VALKFIPKVG
RSEKELKNLQREIEIMRGLHHPNIIQMLDSFETDKEVVVVTDYAEGELFQILEDDGSLPE
DQVQTIAAQLVSALYYLHSHRILHRDMKPQNILLGKDGVIKLCDFGFARAMSIHTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELFMGTPPFYTSSIFQLVSLIVKDPVKW
PKAISPAFKSFLQGLLMKDPRQRLSWPELLSHP--FVA-GRVTVIDDTEEHGISNPFTTK
LSPELQALKEQQAHSLAPRSGQSRILRKARQKMAEEAQKKVEKSV----GFSGLHPMV--
----MSKAALAEEELPAS-----------FKEKNSGVLQGKKRGQWGSSLTGLFPWP--G
EHSITQDYEREFPQPEAPLQLGVGRAELQGRQSIEAVDLEGE---ELESDEEWQHLIEAT
EPLAMQLSTPLSLLRDPGFRHRVQARLAESAQQVLEGMLEGASHLRPILRVVGNLLATHC
-D---------------SELLNLFCRELNVPLSLLHLAKQMLESGSTKQQPWYITVLTDL
IMVTTIYFSSECSLEESGQ---DSLQTFQESANHFLALLPDLLAETADSEMKLCQQSLLC
FTLLCESLDVMCPSISS-------PFYASLREENEPLLDRLLHGLISEQPAVQVLSFP--
-GAAMEANSTHDQRQCMVDLFTAALAAACSIPLARNSCREAKQQVAQEIAGKLMDGECQQ
LGKLLRKLEHSNCSLNVLKILYAGCYASPSLCQHLGRSQQV-WDFLMQLSKGKVELHCGP
CDW--RVACEASLYLLTLLTLQSQASPSRLEEVVT-----LALDLLTQSPVISV--VG-A
AAFLLTQLDQRGVPVALGGKEILTAVT--SALMEPAEAKMDLPMGAGLYDG-IIFLLLKL
LAQ---EDVAV---EQSFAASELWSMVWHCVPAVLCMGGSGAALEGSSPE-AGPP---VA
EPDWSLLSPQGTLLFLSLALFIFTHET--HRCLPQLTQSHGVLMMMLKTLLSPRFLACLA
QMQARE-NGEAELIPAVVIQACQL----LCFPFALDVDEDTIALVIEAVRDSQIPPQLLQ
VCCHHLPFSDTELPMSLLCRLVVSDEQVTDQIAREAAAS-EHIIAYLSTVLFSGSLTLTT
DLISLLTHVART-CPEHLPFLQRILGGSDMTYQALTHLLSHQEHSIRAKTCILLGNLLRH
SHGFPQV

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQNQTGLLESLLVCLADEDEAVRKAASFAVGNAAYH

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

ESS---P

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1347)

AGTLGKAVPR
LTQLLSDQQAKTRCNAASALGNLGRR

ENSGT00910000144066_2_Linker_3_5 (1347, 1360)

SAELG-ELLIESR

PF02985 // ENSGT00910000144066_2_Domain_5 (1360, 1391)

TPHILLEVACQDPQASVREGA
LIALCAVSRHPGIQQVLLSLRASEQLAALAGSDSW------PTAGGSPRPSSARHCQKLI
RLLTPLQST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAKQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGEAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETT
EPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKAGL---IRDVASSEMWTVLWHRFSTVLRLPKEASAQEGELLL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
HAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSNQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SMALRGALQSQSGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------HSSPRPASAKHCRKLI
HLLRPTHSM-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRHRLSWPDLLHHP--FIA-GRVTIITEPAGSDLGTPFTSR
LPPELQVLKDEQVHRLAPKGNQSRILRQACKHMAEKAKQKKKQNA----GPALEPEER--
----LSKVTLGSAPVPEL------KASPQESSLLASILDSEMKSNWEDWVAGEAPPTPR-
EDHITLECEQVFPELRPET-------M--GQQNTDAMDLENE---EPDSDDEWQRFLETT
EPVPVHLKAPLTLLCNPDFCQRIQSQLRGTAEQILKGILEDASHLLPALRVLSSLLSS-C
SD---------------SVLLYSFCQEAGLPRLPLSLLRHSQESSSIQKQPWYRAFLRDL
VAVVQAYFSCTFNLERSQTGD--SLQVFQEASNLFLELLGKLLTQSDDSEQTFRRDSLMC
FAVLCEAVDGNSQAISN-------AFYSSLLTTQRAVLDGLLHGLTVPQLPF--HTPP--
-GAPQVSQPLREQCEDIPGAISSALAALCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQL
RPSLVSGLRHHILCLHLLKVLYSCCYISEHLCHILGQEPLA-LESLLMLVQGKVKV----
ADW--EESTEVALYLLSLLVFRLQDLPSGMEKLGS-----EVATLFTHSHVVSL--VN-A
AACLLGQLSQQGVIFDLQPQEWISAAA--HALSAPAEVRLTPPCSCGFYDG-LLILLLQL
LT---QGKPGL---IRDVAASEVWTILWHRFSMALRLPEEVTVQEDDLSL-SSPP---SL
EPDWTLISPQGMSALLSLAMAIFTQEP--QLCLTHLSQHGSILMLTLKHLLSPSFLHHLS
QAPQ-----GPEFLPVVVLSVCQL----LCFPFALDVDADLLVGILADLRDSEVAVYLLQ
VCCHHLPLLQAELPIGLLTRLALMDSTSLKQFVDTVATSSRTIISFLSIALLSDQPRMIS
DLLSLLTHTARVLSPSHLSFIQELLSGSDESYRPLRNLLGHSENTVRVRTYRLLGHLLQH
SMALRGALQSQAGLLS

PF13646 // ENSGT00910000144066_2_Domain_3 (1277, 1385)

LLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPS
MTQLLGDPQDGIRRNAASALGNLGPE--GLG-KELLQCQVPQRLLDMACGDPQPAVKEAA
LIALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLPN------SG-TRPASARHCRKLI
HLLRPTHST-

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 166)

YHVLEMIGEGSFGRVYKGRKKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQTIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------

--------------------MEK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYNHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRW
PSTISPCFKNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPAGPDLGTPFTSR
LPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNT----GPALEQEDK--
----TSKVAPGTAPLPRL------GATPQESSLLAGILASEMKSSWVESETGKAPPAPR-
ENWTTPDCGQAFPEERPEV-------L--GQRGTDAVDLENE---EPDSDNEWQHLLETI
EPVHIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSS-C
SD---------------SVALYSFCREAGLPGLPLSLLRHSQESNSLQQQSWYGTFLRDL
MAVIQAYFACTFNLERSQTGDSPSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSRAISK-------AFYSSLLTTQQVVLDGLLHGLTVPQLPV--HTPP--
-GAPQVSQPLREQSEDLPGAISSALAAVCTAPVGLPDCWDAKEQVCWHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCLVSERLCCVLGQEPLA-LESLFVLVQGKVKV----
VDW--EESTEVTLYFLSLLVFRLQNLPCGMEKLGS-----DVATLFTHSHVVSL--VS-A
AACLLGQLGQQGVTFDLQPMEWMAAAT--HALSAPAEVRLTPPGSCGFYDG-LLILLLQL
LTE--QGKASL---IRDVASSEMWTVLWHRFSMVLRLPKEASAQEGGLSL-SNPP---SP
EPDWTLISPQGMAALLSLAMATFTQEP--QLCLSCLSQHGSILMSILKHLLCPSFLNQLR
QAPH-----GSEFLPVVVLSVCQL----LCFPFALDVDADLLIDILADLRDSEVAAHLLQ
VCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTS
DLLSLLAHTARVLSPSYLSFIQELLAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQH
SVALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNATYQAGP---LGPALAVAVPS
MTQLLGDPQAGIRRNVASALGNLGPE--GLE-EELLQCQVPQRLLEMACGDPQPNVKEAA
LIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLP-------RSSPRPASAKHCRKLI
HLLRPTHST-

--------------------MEKYH

PF07714 // ENSGT00910000144066_2_Domain_0 (26, 269)

VLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRW
PTAISPCFKSFLQGLLTKDPRQRLSWPDLLHHP--FIA-GRVTIITEPGSPDLGTPFTSR
LPPELQVLKDQQVHRLAPKGNRSRILQQACKHMAEEAKQKKHQNT----GPALAQEDR--
----TSKMACGTAPLPRL------RATPQEPGLLAGILASEMKSSWAEWGAGEAPPAPR-
ENRIAQDCERILPELRPEV-------V--GQRSIDAVDLENE---EPDSDDEWQHLLETV
EPVPVQLKAPLTLLCNPDFCQRIQGQLHEAGGQILKDVLEGASQILPALRVLSSLLSS-C
CD---------------SVPLYSFCREAGLPGLLFSLLRHSQESSSIQQQCWYGTFLRDL
MAVIQAYFGCTFNLERSQTGD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMC
FTVLCEAMDGNSWTVSK-------AFYSSLLTTQRAVLNGLLHGLTVPQLPF--HSPP--
-GAPQVSQPLREQSEDLPGAMSSALAAICTAPVGLPSCWEAKEQISRHLANQLTEDSSQL
RPSLISGLQHPILCLHLLKVLYSCCHVSEHLCHLLGQEPLA-LESLLLLVQGKVKV----
VDW--EEATEVALYLLSLLVLRLQDLPSGMEKLGN-----EIATLFTHSHIVSL--VT-A
AACLLGQLGQQGVTFDLQPVEWIAAAS--HALSAPAEVRLTPPAGCGFYDG-LLILLLHL
LTQ--PGKGSL---IRDVASSEMWTVLWHRFSMALRLPEEVSAQEEEPSL-SRPQ---SP
EPDWTLISPQGVAALLSLAVAIFTQEP--QLCLSHLSQRGSTLMSTLKHLLSPSFLHPLG
RAPH-----GSEFLPFVVLSVCQL----LCFPFALDVDDDLLGGVLADFVDSEIAAHLLQ
VCCHHLPLPQAELPVSLLTRLALTDPTSLNQFVNAVAASPRTVISFLSVALLGDQPVLTS
DLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRARTYGLLGHLLQH
SMALRGALQSQAGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGP---LGPALAAAVPG
MTQLLGDPQAGIRRNAASALGNLGPE--GLG-AELIQCQVPQRLLEMACGDPQLNVKEAA
LIALRSLRQEPCIHQGNNERDSR-------------------------------------
----------

--------------------MGK

PF00069 // ENSGT00910000144066_2_Domain_0 (24, 277)

YHVLEMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLG
RSEKELRNLQREIEIMRGLRHPNIVHLLDSFETDKEVVVVTDYAEGELFQILEDDGKLPE
DQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGI------FARAMSTNTMVLTS
IKGTPLYMSPELVEERPYDHTADLWS-GCILYELDVGTSPFYTTSIFELVSLILXXXXXX
XXXXXXXXXNFLQGLLTKDPRQRLSWPDLLHHP--FIA-GCVTIITEPAALDLDTPFTSR
LPPELQVLKDEQAHRLAPKGNESHILRQARKRMAEEAKQKKHQNA----EPALEQEDQ--
----TSKVAPGTASLPKL------RTTLQEPGLLAGILASEMKSNWDEWGAGEAPLTPR-
EHPITVDCEQAFPELTPET-------I--GQRSIDAVDLENEXX-XXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXILKGVLEDAFRILPALRVLSSLLSS-C
RD---------------SVALYSFCREAELPGLLLSLLKHSQDSTSLQQQSWYGAFLRDL
MAVIQAYFACTFNLERSQTSD--SLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMX
XXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX--
-XAPQVSQPLREQSEDLPGAVSCALAAVCTAPVGLPGCWDAKEQVSQYLANQLTDDSSQL
RPALISGLQHPVLCLHLLKVLYSCCRVSEHLCHLG-QEL--LLESMLMLVQGKLKV----
VNW--EESTEVTLYLLSLLVLRLQDLPSRMEKLGS-----ETATLFTHSHIVSL--VS-A
AACLLEQLCQQGVTLDLQPVEWIAAAT--HALSAPAEVRVTPPHGCGFYDG-LLILLLQL
FTQ--QGKTSL---IRDLANSEMWTVLWHRFSMALRLPEEVSAHEEELSL-FSPQ---SP
EPDWTLISPQGMAALLSLAVSTFIQEP--QLCLGHLSQRGSILMSTLKHLLCPSFLHWLG
QAPH-----GSELLPAVVLSACQL----LCFPFALDVDADLLVGILADLRDSEVATRLLQ
VCCHHLLLPQVELPMSLLTRLALTDSTSLSQFVNAVAASPSPIIEFFSAALLGDQPLVTS
DLLSLLAHAARVLSPHYLSFIQELLAGSDESYRPLRSLLGHAENSVRARTYGLLGHLLQH
SMALRGA

PF02985 // ENSGT00910000144066_2_Domain_2 (1268, 1304)

LQSQPGLLNLLLLGLRDKDPVVRRSASFAVGNAAYQ

ENSGT00910000144066_2_Linker_2_3 (1304, 1311)

AGP---L

PF02985 // ENSGT00910000144066_2_Domain_3 (1311, 1349)

GPALAAAMPS
MTQLLGDPQAVIRRNAASALGNLGPE--GLG-EELLRCQVPQRLLEVACGDPQSNVKEAA
LIALRSLQQEPCIHQVLVSLGASEKLALLTLGNQLLP-----HNGSSPRPASAKHCRKLI
HLLRPTHNA-