ENSGT00910000144006_1 : Linker Region Query Results

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-------MSRHFSSRSGYRCGGG--------------------------G-GGFSSGS--
AGVVSY------QRRSTSSSV----RRSGG-GGG--------------------------
---------RFSG---------------G----VCGGGAGGGFGSRSLINLG-GS----K
SISISVAGGGGR-GGFGGGYGG-G--YG-------------GGGFGGG------------
-GFGGGGFGGG------------------------GFGGGGI-GGGFGG----GGFG-GG
--------GFGGGGF------------PVC-P--GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KIK-SQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINT---ST--RTYSLEPFFEAYISNLRRN----VDQLKSDR
-----------SRLDS-----ELKNMQDLVEDYRS--KYEDEINKRTNAE--NEF-VGIK
KDVDA----AYI-TKVDLQAKFDNLL---QEIDFFKTLFQAELS-QM-QTHISDTNVIL-
-SMD-------------------NNRNLDL--------NSIIDEV-KNQYEEIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGQHGD-SLKNTKM--------------EI
SELNRVIQRLRSE--I---------DSVKKQ-----------------ISSLQQ----AI
SDAEQRGENAIKDAQNKLNEL---------------EDALQKAKEDMARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRTL
LEGEES R------------MSGECV--PNVS---------VSVSTSHT------------
---------------------------------------SISGGGGRG--G---------
-------------------------GGF--------SSG-GGGYSSGGGG----------
GYGSGGGGGYG--SGGGSS-----------YG----------------------------
-SR--GGGSYGSGG-GSS-------G-------------S--------RRGGSGGGGG--
------GSGGSFSSSGGRAS--------------------------------------ST
K----TSGGSSSV-------KFVST-SYSR------------------------------
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--------------------GTR-------------------------------------
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-------MSCQISCKSQRRGGGG-GGGG---------------------GFRGFSSGS--
AVVTGG------SRRSTTSFSC--LSRHGGGK----------------------------
--------------------------------------GGGGFGSRSLVGLG-GY----K
SISTSVAGYGGGVGFGGGGFGGGR-GFGG------------GSSFGGGRGFGGGSGFGGG
SGFGGG---------------SGFGGG-------SGFGGGSFGGGGSFGALGGPGGSRPG
--GFPG-GS-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KD-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EI-LQQLDV---ST--RTTRLDPIFQAYIGMLKKR----VDSLCAER
-----------TSQDS-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NDF-VTLK
KDVDG----CYM-DKVELQAKADILN---QETEFLRTLYDAEVS-QL-QQTVTDTNVIL-
-SMD-------------------NNRTLDL--------GSIIADV-QAQYEEITQKSKSE
AEELYHS---------K----YEEL-QI-TAGKHGE-SLKELKM--------------EI
SELNRTIQRLQAE--I---------SHVKKQ-----------------CKNVQD----SI
ADAEQRGEHAIKDAKTKLVDL---------------EDALQQARENLTRL-------LR-
------DYQELMNVK-------------------------------L-ALDLEIATYRKL
LEGEEWE------------KGTLV---HFLL---------RTVT----------------
-------SST----------------------------ISSNVASRAGFSSGGQG--SGG
RGS---SYGGS---------------------GGGYSSG-SSSYGSGGRGSG------SR
S-GGGGGG---------GS--RGG--S---------------------------------
---------------------GSGGFSSGGGSRGGS--GSGGFSSGGGSRGGSG--SGGF
SSGGGSRGGSGGFSSGG--------G-------------SGGGSRG--------------
---------------------------------GGSGGFSSGGGSRGGSG----------
-----SGGGGSEEG---------C---------------------------------GSG
---------VTLSFR---------------------------------------------
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-------MNRQFTCKSGAA------------------------------TKGGSSSCL--
AVLP-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSWSLYSLG-GG----R
NISISVAGG--SGL-TG------------------------GY-----------------
------------------------------------------------------GFGRGR
VSGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LD-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYVGNLRKK----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSYISDTSVIL-
-SMD-------------------NNRKLDL--------DSIIAEVR-TQYEEIALRSKAE
AESLYQMK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRLE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSPA---G-------
---------------------------------------------TAGTGAS--------
-----------------------------------FGFSGAGTYG-YRP-----------
-----------------SS-------ASGGYSI---------------------------
----LSGGCIT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSTS-----EFK-------D------------------------
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-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---KN--CRNNLEPIFEGYISSLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEAEINLRTAAE--SEF-VTLK
KDADA----AYK-VKVELEAKVDSLD---KDIKFLKCLYEAETA-QI-QTHASETSVIL-
-SMD-------------------NNRSLDL--------DSIIAEVR-THYEDIALKSKAE
AEALYQTKSILITTILPLELQIQEL-QL-AAGRHGD-YLQHTR--------------SEI
SEVTRLIQRLHCE--I---------ASVKK-----------------QCGNLET----AV
ADAEQRGDSALKDARAKLDEL---------------ESALHQAKEELARM-------MR-
------DYQELMSMK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSPVS-----------ISVISSSN------------
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-----------------------------------------YSYG-YHP-----------
-----------------SS-------LGAELGT---------------------------
----GSVA-------------------------------------------GSSGSTQ--
--------SRQAKATGARMR-----DAK-------DFQ---GKN------AL--GSTPSG
RKATR-------------------------------------------------------
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-------MSHRFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQVVGSVCQSRGRCSGGGY-----------GGGFSSRSLYNLG-GS----K
SIFGSLVGRSASG--FCPGGGA--------------------GGFG------------AG
RS---------------FGG-GGFGGG--------GYG-----GGRFG-----GGFGGAG
--FG-AGFGGFGGFG------------PSF-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-NQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---TT--RTSSLEPIFESYISQLQRQ----VDFLNSER
-----------SHQNL-----EIRSMQDVVEDYKS--KYEDEINKRTNAE--NDF-VVMK
KDVDA----AFM-GKSDLQSKVDTLY---GEVNFLKYLFDTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNIQRLQAE--I---------NSVKKQ-----------------VGRMHG----SI
SDAEERGERALQDAKQKLQDM---------------DEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTVGGGSYGGGSG---------
--------------------------------------------YGGG------YGSSSR
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---------------GGSGGYGGGAGSR--G-----------------------------
-------GGGS-YGSS-SKS--------------SSKY----------------S-----
G----RSGGSSRT-------HIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
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-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
ASLLQG------CRPNFSSFS---VSKNRKSI----------------------------
-----------------------------------GGGFGGSFGTRSLHGFG-GS----K
RISISGV------------YRSSRGS---------------FGG------------ASCG
LGIGST-----G----YRAG---------------------GAFGGYG------------
-------YGG--G--------------MVH-GP-GG-I-QE-VT----------VN-H-S
L--LTP-LH-LE-ID-PS-LQ-HVR-KE-E------------------------------
------K-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQDH-----KT--TRANLEPMFEAYINNLRRQ----LDCLGGER
-----------GRLEM-----ELKNMQDVVEDFKI--KYEEEINRRTAAE--NEF-VVLK
KDVDA----AYM-SKVELEAKVDALM---DEINFLRAFYEAELA-QL-QAQLSETSVVL-
-SMD-------------------NNRKLDL--------DSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QR-SAGQHGD-DLRTTRM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CVTLQA----AI
TDAEQRGELALKDAKNKLAEL---------------EEALQKAKQEMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEEHR------------LTGEGV--GPVN---------ISVV----------------
-------SSS----------------------------GGTGYSRGSGLCVGGGG-----
-----------------------------------YSGG------L--------------
--------------SS--G--------------------------------------LCY
S------------------GS------------G-----GSSF---------SSTSGR--
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-----SLSGTSSS--M----RIISK-TSSTK-----------------------------
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---------------KSYRS----------------------------------------
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-------MSHQFSSQSAFSSRS----------------------------RRVYSAGS--
---------------------------SAGS-GGG-------------------------
---------SRAVRSVCQARGRCGSG-G-----GGYGSHARGFTSRSLYNLG-GS----K
SISISLVGRSASG--FCQGGGA-------------------GGGFG------------G-
--------------------------------------GRSFGGGGYG----GGGLGGAG
--FR-GGNLGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-MQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--QTNNLEPIFESYISKLQRQ----VDCLRAEQ
-----------MRQSS-----EIRSMQDVVDDYKS--KYEEEINRRTSSE--NDF-VVLK
KDVDS----AYL-SKAELQSKADTLL---EEVDFMKYLFQSELS-QM-QTNITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RIQYEEIAQRSKDE
AEALYQT---------K----FQEL-QI-TAGRHGD-ELKTSRM--------------EI
SELNLTIQRLQAE--I---------GNVKKQ-----------------IEHMHT----II
SDAEERGQQALQDAQQKLQDL---------------EAALQQSKEELARL-------LR-
------DYQALVGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------ISVQ----------------
-------SSQ----------------------------LTIGGGARGSGGY-----SG--
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-------------------GSRGGSGGYGGGSG-GASGG-------------------GY
G-----SGGGS-YGGSSKSS----------------------------------SKYG--
G----GSGDASRM-------QIIQT-STS-------------------------------
---------------------------------------------------------TSH
RRKLE-------------------------------------------------------
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-------MNRQFTCKPGAA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-GA----R
SISFNVAGG--SGR-TA------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGALG-PS---NP----SLGL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLDL---NN--CKKNLEPVYEAHISSLQKQ----LDALSGDR
-----------VRLDS-----ELRGMRDAVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------EYQELMSMK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTP---G-------
---------------------------------------------AVGAGAS--------
-----------------------------------FGFGSTSTYG-YRT-----------
-----------------SS-------VGGGYNI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-ETKARLGSAS-----EFK-------DVS---GKT-------S--ALGSPT
KKTMR-------------------------------------------------------
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-------MSRQLN-VKSGG------------------------------DKGGFSGHS--
AVVL-RK-------VGGSVASY----RAPS------------------------------
-----------------------------------KGA-GAAFGSRSLYSLCRGD----L
CIPLKVAGS--SVR-TG------------------------GYNFRLS------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSAVLG-SV---CPSMCPSMCP-P-GG-I-HQ-VI----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQLDL---NN--CRKNLEPILEGYVGNLQKQ----LETLSGDR
-----------LRLDS-----ELRGMRDLVEDYKK--RYEVEINQRTAAE--NDF-VVLK
KDVDA----AYT-VKVELQAKVDSLD---KDIQFLKCLYDAEVA-QI-QTHTSETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQSK-------------IQEL-QL-AAGRHGD-DLKRTK--------------NEM
SELNRLIQRIRCE--I---------ANVKKQVGSK------P-AESTECANLET----AI
ADAEQRGDSALKDARAKLDEL---------------EAAMHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYCKL
LEGEECR------------MSGENPSSVS-----------IFGDSDWT------------
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-----------------------------------------GNSG-SHP---------G-
-----------------SL-------AGTDLGA---------------------------
----STTAST-----------------------------------VT----SSSRSTR--
--------SGQTRAKGAQGG-----DPK-------DSQ---DKS------TP--GSGRAR
-KAAR-------------------------------------------------------
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-------MSRQ-FTCKSGS------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SITLNMAGG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFSRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINHRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYP------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGETRSR-GSAS-----DYK-------DTL---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
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-MSCVP----SSTRG---GFSARSA-----------------------------------
----------------CSARVGN----WG-RGGIWGSRMAGGFSSKSFCSMG-EA----R
GISGRRG-----------------------------------------------------
-----RSWGLGG--R-FG-G---------------------------------K-F-G--
-------Q-V----G-VG-A-G-----L-CP-P-GG-I-QE-V---------T-IN-Q-D
L-L-SP-LK-IE-ID-PQ-FQ-TAR-AQ-E------------------------------
------TQ-QI-RA-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-QL-LQDQR----GMGGHLQTMEPVFEDYIACLRRQ----LEQLQGEQ
-----------GALAL-----ELKACQEQEEDYKT--KYEQEAHKRPTAE--NDF-VVLK
KDVDG----VYM-SKVELEVKVDTLQ---EMIKFLKHVFEEEIS-QF-QTHVNNTSVVV-
-SMD-------------------NNRYLDL--------GSIVSEI-RAQYEIIARKSKAE
AEAMYQT---------K----XXXX-XX-XXXXXXX-XXXXXXX-------------X-X
XXXXXXXXXXXXX--X---------XXXXXX-----------------NATIQW----AI
TDAEQRGEKALKDAKAKVVDL---------------EGALKKAKQDMASL-------LR-
------DYQELISTK-------------------------------L-ALDVEIATYRRL
LEGEECR------------ISGEHIDNVSIR---------CTFFFVAV--VGGGTSS---
---SGGCGNSGF------------------------------------------------
-GCS----------SVVV--------------GGTRLV-------KG-SGSGS-----VS
ASGSAFS----------GSS--SGSVTGTILKK---------------------------
---------TTMS---TLKTITY-------------------------------------
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-MSLSP----GRAQR---GFSARSA-----------------------------------
----------------CSGPSG------------PS---RSSFSSRSLSPFR-GC----R
R-AS-SG-----------------------------------------------------
-----TAWGSGG--R-LG-K---------------------------------W-F-G--
-------G-GR-G-G-SG-L-S-----Q-CP-P-GG-I-QE-V---------T-IN-Q-Q
L-L-SP-LK-VE-ID-SQ-FQ-TVR-TQ-E------------------------------
------TQ-EI-RA-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQQQQ---GVSGRQQSLDSVFEAYFSQLRHR----VEELQRDR
-----------RALDA-----ELTTFRNQEEEYKA--KYEQEAYTRATVE--NDF-VVLK
KDVDE----AFL-GKMELEGKLEVLR---EYVCFLRRLYEEELS-QL-QTQVGDTSVVL-
-SMD-------------------NNRCLDF--------SDIITKV-QAQYEEVARTSKAE
AEALYQT---------K----YCEL-EA-SVQSHGD-SIRESRA-------------Q-I
SQLHQAIQRLQSQ--M---------QTLRKQ-----------------NDHLQS----AI
ADAEQRGELALQDAQAKLVDL---------------EDALRKAKQDLARL-------LC-
------DYQELLSTK-------------------------------L-ALDVEIATYRRL
LEGEECR------------MSGECTSQVTIS----------------A--VGG-------
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-------------------------GSTVSGGAGGD--VGTCGFGGWKGSFGA-SCSSQV
IGGSSVVLDSG---------------------KGAVFGSCSVSGSGSSS----GSSCSTI
LKKTVESTLKTSITY---------------------------------------------
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-------MSRQFSCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSMG-GP----R
SISFNVTSG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVGLG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPIFEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESIN---QEIKFFRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISIV---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSW-GSTS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
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-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-RGGFSSRSLYSLG-GP----R
SISFNVASGSGSGW-TG------------------------SY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGNVALG-SM---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIA-KSKAE
AETLYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------AAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
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-------MSRQLHHY-HGR------------------------------ERPGFSGCS--
AIIS-GL-------VSGNSASF----RA-G------------------------------
----------------------------------VK--STTAFGSRSLFSLG-GG----R
RLALSAG----AGR----------------------------------------------
--------------------------------------------------------GGGR
VAGFVGTVFGSAGLG-ST---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-ME-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LKQLEL---NN--SRKTLEPIYEGFISALRKQ----LETHSGDR
-----------VRLDS-----ELRNMQDMVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFYKRLYEGEIT-QL-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DGIITEVR-AQYEDIALKSKAE
AESLYQTK-------------IQEL-QL-MAGRHGD-DLKCTK--------------AEI
SEINRLIQRIHSE--I---------GNVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKDELARM-------LR-
------EHQQLLTVK-------------------------------Q-ALDIEIATYRKL
LEGEXYK------------MSGEFPNSVS-----------ISVISNTGT---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGATTASSYS-YKPA--------A-
-----------------AE-------VKTKG-----------------------------
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--------------SCG-S------EFK-------DPI---AKT-------S--GSSCAT
KKGPR-------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRRGGGG--GGGG---------------------GFRGFSSGS--
AVVSGG------SRRSNTSFSC--ISRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISSSVAGNSGG--YG------GS-SFGG------------SSGFGGGRGFGGGSSFGGS
IGFGGG----SG----FGGG-QGFGGGSRFGG-GSGFGGGGFGGGGFGG----GRFGGGP
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NLK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GS--RTTNLDPIFQAYIGILKKQ----MDRLTAER
-----------TSQES-----ELNNMQDLVEDFKK--KYEEEINKRTSAE--NDF-VTIK
KDVDS----CYM-DKTELQARLDILA---QEVNFLRTLYDAELS-QL-QQDVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QSQYEMIAHKSKAE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHAIKDARGKLTDL---------------EEALQQCREELTRL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDFS--DNVS---------VSIT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GGR---------------------GGG-GGG-GSTYGSGGRSSG------SR
G-----SG-GGGYSSGGGS--RGG--SGGGYGSGG-------------------------
---------GSSS--------GGGGYGSGGGSRGG--SGG-GYGSGGGS---SSGG-GGY
GSGGGSRGGSGG-------------G-------------YGSGGGSR-----GGSGGGGV
S----SGGGSRGG-------------------------SSSGGGSRGGSS------SGGA
GSGSEKGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGAA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-SP----R
SISFNVASS--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGALG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--CRRNLEPVYEAHISSLQKQ----LDSLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIT-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------ERALHQAKEELARM-------LR-
------EHQELMSMK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSAP---G-------
---------------------------------------------TVGAGTS--------
-----------------------------------FGFSSTGTYG-YRQ-----------
-----------------SS-------VAGGYGI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-DTKSRLGSAS-----EFK-------EVS---GKT-------L--ALGSPS
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRR--GG--SGGG---------------------GYRGFSSGS--
AVVSGA------SRRSTSGFSC--LSRHGGGG----------------------------
-----------------------------------GGYGGGGFGSRSLVGLG-GT----K
SISISVAGGGGSFGSGGGFGGRGV-GFGG------------GSGFGGGS------GFGGG
SGFGG-----GG----FGGG-SGFGGG-------SGFGGGGFGGGRFGGP---GGFG---
--GFGG-PGGPGGSG------------PGGFPG-GG-I-HE-VS----------IN-E-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---SS--RTTHLDPIFQAYISVLKKQ----VDGLNAER
-----------TSQNS-----ELNNMQDLVEDFKK--KYEDEINKRTALE--NDF-VTLK
KDVDS----GYT-NKVDLQINVDLLT---QEIEFLRTLYEAEVS-QL-HQTITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-QAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGE-SLKEFKM--------------EI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKSVQD----AI
ADAEQRGENALKDAQNKLTEL---------------EEALQQAREDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEEYS------------TFCGNI---LSP---------AAVT----------------
-------SSS----------------------------ISSSVASRSGFGGQ--------
------G--SG---------------------GRGFSSG-SSSYGSGGRGSG------SR
S----G-G-GGGFSSGGGS--RGG--SS--------------------------------
---------------------SGGGFSSGGGSRGGSSSGGGFRGSRGGSG-----SGGGF
SSGGGS---------RG--------G---------------------------SGSGGGY
S----SGGGSRGG--SSSGGGFSSR-GG----SSSGGGFSSGGGSRGGSG------SGGG
VSGSEKGGSGSGEG---------C---------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSCKSGAA------------------------------SKGGFSGYS--
AVLS-GG-------GS---TSY----RAGG------------------------------
-----------------------------------K----GGFSSRSLFSLG-GA----R
NISFNVASG--NGK-NG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RFEDEINKRTAAE--NEF-VLLK
KDVDA----AYS-NKVELQAKVDSME---NEIKFLRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELLSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFLSP----------------VSISII---S-------
---------------------------------------------N--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-GSAS-----DYK-------DTL---GKG-------S--SLSAAS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

-------------------------------------------------MGEDKSLVPGP
RGRNSHTLASLCSSSV-----------------------------------AVPPSVS--
AMSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARGRG-----------RG---RCSFSSRSLSSFR-GC----R
G-GS-RG-----------------------------------------------------
-----RAWGLGG--R-LG-V---------------------------------R-F-G--
-------E-GN-G-G-PG-L-S-----L-CP-P-GG-I-QQ-V---------T-IN-Q-N
L-L-TP-LK-IE-MD-PQ-FQ-VVR-TQ-E------------------------------
------TQ-QI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-HL-LQQ--Q---GVRDSPQGLESFFEVYVAHLRKQ----LEQLQRER
-----------GALDA-----ELKSCQDQEEEYKA--KYEREALRHATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLKALK---EYICFLRRLYEEELG-QL-QTQAGDLSVVL-
-SMD-------------------NNRRLDF--------RDIIAEV-RARYEEITRTSKAE
AEMLYQT---------K----YQEL-QV-SAQLHGD-CMKETKV-------------Q-I
TQLQQAIQKLLSQ--I---------ENLKKQ-----------------NANLQA----AV
ADAEHRGELALKDAQAKLVEL---------------EAALRTAKQDLARL-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRRL
LEGEESR------------MSGECASQVTIS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NAIVSGGADGGL-VGTCGLGGEKGSVGS-RCSSIV
TGGSSVVTGGSSISTRGSSMVTKGSNVIVVSGQSPALGSSSVPGSGSSSSSTSSFTSRTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARSRG----RS-RGGFSS---RGGFSSRSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-WS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYEEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYLYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
PQLHQEIQRLQSQ--I---------ESLKKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------FSSSHASV----RA-G------------------------------
----------------------------------IK--GT-AFGSRSLFCMG-GG----R
RLSLSS-----AGR-SG------------------------GFALGHG------------
------------------------------------------------------GASGGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--SKRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---NDLKFFKVLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILTEVR-AQYEEIAVKSKTE
TENMYQCK-------------IQEL-QA-TVGQHGD-DLKLTK--------------AEI
TDINRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MGGEYPNLVN-----------ISVVSSTSA---G-------
-------------------------------------------PGGAGFSVD--------
-----------------------------------LGSL--SSYS-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-SS-----ELK-------DPP---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRRGGGG--GGGG---------------------GFRGFSSGS--
AVISGG------SRKTTSSFSC--LSRHGGGG----------------------------
-----------------------------------GG--GGCSSSQSLVGLG-GS----K
RISMSVAGGGGSFGSGGGFGGRGG-GFGG------------GGGFGGSS------GFGGG
SGFGG-----G--------G-SGFGGG-------SFGGGGGFGGGGFGG----GRFGG--
----GG-FGGPGGFG------------PGGLPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---GS--RSTNLEPIFQAYIGMLKKR----VDELSAES
-----------NSQDL-----ELNNMQDLVEDYKK--RYEDEINKRTTAE--NEF-VTLK
KDVDS----CFT-GKTELQTKADILQ---QEIQFLRALYDAEIA-QL-QQNVTETNVIL-
-SMD-------------------NNRDLDL--------DSIISEV-QSQYEEIAQKSKVE
AEALYHS---------K----YEEL-QI-TAVKHGD-SLKDIKM--------------QI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKNVQD----SI
ADAEQRGEHAIKDAKNKLLDL---------------EEALQQARENLACL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEIS--NDVT---------VSVT----------------
-------SST----------------------------ISSSVASRAGFG-D-SS--SGG
KGP---S--GG---------------------RGGVSSG-SSSYGSGGRGPG------SW
G-SGSG-S-GGGYGSGGGS--RGG--SG--------------------------------
---------------------SGGGYSSGGGSRGGSGSGGGSI---GGSG-----SGGGY
GSGGGSRGGSGS---GG--------G---------------------------SGSGGGY
G----SGGGSRGG--SG-----------------SGGGYGSGGGSRGGSG------SRGG
VSTSGKSGAGSEEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
---------------------------------------------------------M--
SLSPGR----A--RR---GFR---------------------------------------
------------ALSACSVR-------------PGARGSQGSFSSRSLSASG-GR-----
----------------------------------------------RG--------ASQ-
----GRAW--------------G----A-------------------------------V
---RPRPWGG-----------RP----VRCP-P-GG-I-QE-VS----------FN-Q-N
L--LIP-LK-IE-ID-PQ-FQ-EVR-TQ-E------------------------------
------T-QAI-RS-LN-NQ-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XXXXXXXXXXXXXXXXXXX--X----XXXXXXXXX
-----------XXXXX-----XXXXXXXXXXXXXX--XFEQEAQRRATVE--NDF-AVLK
KEVDG----VFL-SKMELDDRHESLR---VYVDFLRHLYEEEQA-QL-QTQASDMSVVL-
-SMD-------------------NNRCLDF--------KDVIAEV-RTRYEEIARASKAE
AEAAYQS---------K---VYQEL-QR-SVQQRGD-SVQVTRG--------------QI
SQLQQAIKKLQSQ--I---------ETLKTQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQYSSRSLCRSG----------------------------G-KGFSSGS--
AGLVSF------QRRSTS-SV----RRSGG-GGG--------------------------
---------RFSG-------GFCGSG-------GG----GGGFGSRSLINLG-GS----K
SISINVAGGG-SRSGFG---------------------------YGGG------------
-VFGGGVFGGGV----FGG-------G-GLGGGN--FGS-------------GGGFG-GG
--GY-G-----GGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KIK-SQ-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RSFSLEPYFEAYISDLRKQ----VDRLRSDQ
-----------SRMDS-----ELKTMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQAKVDNLR---QEIDFLTALYEAELS-QM-QTHISETSVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQRSKAE
AEALYQT---------K----YEEL-QV-TAGKHGD-SVKTSKM--------------EI
SELNRVIQRLRSE--I---------DSVKKQ-----------------ISQLHQ----SI
ADAEQRGENALKDAQNKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRTL
LEGEESR------------VGLKMT--ESLF---------AAVSTSHT------------
---------------------------------------SISGGSIRG--G---------
-------------------------GGY--------SSG-GGSYGSGGGGGG-----GGG
SYSS---GG--------AS-----------YG----------------------------
-SGGGGG-SYG------------S-GGSSGGHRGGSGGGG--------GS---SGSRG--
------NSGGGFVSSGGRGSG-----------------------------------SGGH
K----TPSGSSSI-------KFVST-TYSR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-DL-LQQ--L---GESDGPRDLGPIFEAYLAQLRRQ----LEQVQRER
-----------GALDA-----ELKNCQDQEEEYKA--KYQEEARLHATAE--NDF-VLLK
KDVDG----VFL-SKMELDGQVEALR---VHVSFLKRLYEQELG-QL-QTRAIDMSVVL-
-SMD-------------------NSRSLDL--------SGVIAEV-RACYEDIAQTSKAE
AQALYQS---------K---VYQEL-QT-SVQLRGD-DMKAVKA-------------Q-I
SQLHRAIQGLQSQ--I---------ENLKKQ-----------------NNNLQT----AI
ADAEQRGELALKDAQAKLDGL---------------EGALRSTKQELARL-------LR-
------DYQELMSVK-------------------------------L-ALDVEIATYRRL
LEGEESR------------LSGECTSQVTVS----------------V--VEGSAVM---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VVPGGV-GGGLGSMCGFGGRQGSSGA-GCSSVV
TGGSSVTLGSG---------------------QSPAVGSCSVSGSS------SGSGSHTI
VKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISFNVASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFSRNR
PSGFAGSIFGSVALG-PM---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFYKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-IQYEEIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRLIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------WVGLDTDPSF--------------SLIAII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-SSAS-----DYK-------DTL---GKG-------S--SLSTTS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSF----WAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
S--LNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYS-FRP-----------
-----------------ST-------VSSGYVA---------------------------
----NSSNCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAN-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSQLLN-IKSGG------------------------------NKGDFSGYS--
AVVP-RK-------AVGSVASY----RAAG------------------------------
-----------------------------------KGT-GATFGSRSLYSLG-GN----Q
RIPFSVAGG--SVR-IG------------------------GYGFGHR------------
-----------------------------------------------------SVHGGGW
ASGFSGSLFGSESLG-PV---CP----SMCP-P-GG-I-HH-VT----------V-NK-S
L--LAP-LN-ME-LD-PE-IQ-KIR-AQ-E------------------------------
------R-EKI-QE-LN-NK-FA-SFI-DK---F-LE---------------------Q-
QN-QV-LET-KW-EL-QE--LD---NN--CKKSLEPIFESYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRVVVEDYKK--RYEMEVNKHTMAE--NEF-VVLK
KDVDA----AYA-AKVEIQAKVDALD---KDIKFLKCLYDAETA-QI-QTHASETSVIL-
-SMD-------------------NNRDLNL--------DSIIVEVR-THYEEIALKSKAE
AEALYQSK--LITTFLSLGNQIQEL-QL-AAGRHGD-DLKLTK--------------NEM
SELNRLIQRIRCE--I---------GNLKK-----------------QCSNLET----TI
ADAEQRGDSALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSG------------
------------------------------------------------------------
-----------------------------------------SSYG-YYP-----------
-----------------SS-------ARADLGA---------------------------
----SSVA-------------------------------------------GSSGSAR--
--------GGDSRAKGTRVG-----DPK-------DSQ---AKN------TP--ITTPAW
-RSTQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLSLY-SGG------------------------------ERPGFSGCS--
AVVS-GR-------LSSSSASF----RPGV------------------------------
----------------------------------KG--TSAAFGSRSLFCLG-GG----R
RLALSA-----AAG----------------------------------------------
-----------------------------------------------------AGRSGGR
LGGFVGTVFGSAGLG-PS---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NL--SRRNLEPIYENRISHMQKQ----LETLSGDR
-----------VRLDS-----ELRNMREVVEDYKK--RYEVEINKRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDAMT---DELKYLKRLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIDDIR-VQYEDIAQRSKAE
SEALYQTK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SELGRLIQRIRSE--I---------GNVKKQ-----------------CGNLET----AM
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYSNAVS-----------ISVVSSSSV---A-------
-------------------------------------------A-GAGFSMG--------
-----------------------------------FGGP--GTYS-YKPV--------A-
-----------------AD-------IKTKG-----------------------------
------------------------------------------------------------
--------------SSG-SS-----ELK-------DSL---GRT-------S--GSGSAA
KKGPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
----------KSSQFSFS-SGYR--------------------------NKRGSSSSS--
AGVLSI------QSRTTSS-S---VRRSGGG---G-------------------------
---------GGFC---------------------SSGSGSGGFGSRSLVSLG-DS----K
SISMNVVRGGGRFGGS---------GFGG------G---G----FGGSF-----------
-----------------GSG-GGFGGG----------------G--FGS---GGGFGGGG
----FGGGGYGGGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RSQNLEPLFEAYISSLRNR----VDQLKSDQ
-----------SRMDS-----EMKNMQDLVEDYRN--KYEDEINKRTSAE--NEF-VTLK
KDVDA----AYL-AKVDLQAKVDNLQ---QEIEFLTTLYQMELS-QM-QTHISETNVVL-
-SMD-------------------NNRSLDL--------GSIIAEV-KAQYEDIAQRSKTE
AEALYQT---------K----YEEL-QV-TAGRHGD-SVKNSKM--------------EI
AELNRMIQRLRSE--I---------DSVKKQ-----------------IASLQQ----SI
ADAEQRGENALKDAQKKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQDLMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECA--PNVS---------VXXX----------------
-------XXX----------------------------XXXXXXXXXXXXXXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXSG------SS
G-GRGGSG-GGGGSSG--------------------------------------------
----------------------------------GRVS-------GGGSSGGSFGSSGGR
G--S---------SSGGTK----TSGVSSS----VKFVSA--------------------
--------------------SYSGT-PG--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSRVP----FGAHG---GFSAHSA-----------------------------------
----------------CSAQLGN----WR-RAGSREAKTNGGFSSRSFCSMG-EA----R
GLSSRGD-----------------------------------------------------
-----RSWAPRG--R-FG-G---------------------------------K-F-G--
-------Q-G----G-VG-A-G-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-SP-LK-IE-ID-PQ-FQ-TVR-AQ-E------------------------------
------TQ-QI-RA-LN-DQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-QL-LQDQE----GMGGHLQTMEPFFEAYMARLRRR----LEQLQGER
-----------GSLAL-----ELKSCQEQEEDYKT--KYEQEAFKRPIAE--NDL-VVLK
KDTDG----VYM-SKVELQGKVDTLR---ETICFLKRIFNQELS-QI-KTHANDASVIV-
-SMD-------------------NNRYLDL--------GSIISEI-RAQYELIAQRSKAE
AEAMYQT---------K----YQEL-QM-SAEKHGD-SIRDTKI-------------Q-I
TELTQAIQRLQNQ--I---------ENIKKQ-----------------NATIQS----TI
TDAEQRGEQAIKDAQVKVVDL---------------ENALKKSKQDMARL-------LR-
------DYQELISTK-------------------------------L-ALDVEIATYRRL
LEGEECR------------MSGEYIDNVSI----------------SM--VGGGTTS---
---SGGCENSGF------------------------------------------------
-SCS----------SVVV--------------GGSHLV-------KD-PGSGS-----MS
ASGSGFS----------KSS--SSSVTGTILKK---------------------------
---------TTMS---TLKTVIY-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKQGAV------------------------------TRAGFSGCS--
AVLS-GG-------SSS---SY----RAGA------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GT----R
SVPFNVACG--PGR----------------------------------------------
-----------A-------G--------------------------------GYGFGRGW
ASGFAGSMLGNVNLG-PS---SP----SMYP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELTSVK-------------------------------L-ALDVEIATYRKL
LEGEECV------------V------------------------SSSMA---G-------
---------------------------------------------TAGAGAS--------
-----------------------------------FGFGGTGTYG-YRP-----------
-----------------SS-------VTGAYGI---------------------------
----LAGGCVT-----------------------------------G----SGNCTP---
--------RGEAKTRLGSAS-----EFK-------DVP---GKT-------S--ALSLPT
KKTVR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
ASLLPG------C-PNFSSVS---VSQSRKSI----------------------------
-----------------------------------GGGFGGGFRTRSLHGFG-GS----K
RISISGG------------YRSSQGS---------------FGG------------ASCG
LGIGGM-----G----YRVG---------------------GDFGGYG------------
-------FGG--G--------------MVS-GA-GG-I-HE-VI----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------K-EQI-KT-LN-NK-FA-SFI-NK-VRF-LE---------------------Q-
QN-KV-LET-KR-SL-LQDQ-----KS--TRTNLEPMSEAYINNLRRQ----LDRLGGER
-----------GRLEM-----EPKDTQDVVEDFKN--KYEEEINRRTAAE--NEF-VVLK
KDVDT----AYM-NKVELEAKVDSLM---DEINFLRAFYEAELA-QL-QAQFSETSVVL-
-SMD-------------------NNRKLDL--------DSIIAEV-KAQYEDIANCSRAE
AESWYQT---------K----YEEL-QW-SAGQHGD-DLRTTRM--------------EI
SELNRAMQRLRLE--I---------DNLKKQ-----------------CATLQA----AI
ADAEQHGELALKDAKSKLAEL---------------EDALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEEHR------------LTGEGV--GSVN---------ISVV----------------
-------SSS----------------------------GGTGYSGGSRLCVGGGV-----
-----------------------------------YSGG------F--------------
--------------SG--G--------------------------------------LCY
S------------------GS------------G----GGSSF---------SSTSGH--
------------------------------------------------------------
-----SLSGTSSS--M----RIISK-TSSTK-----------------------------
------------------------------------------------------------
---------------KSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGI-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNR-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YAGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFSSQSAFSSRS----------------------------RRAYAYRS--
---------------------------SSGF-GDG-------------------------
---------SRAVGSVSQGWGRPGS--------GGYGGHGRGFSSRSLFNLG-GS----K
SISLGLVGRSASG--FHQGRGA-------------------AGGFG------------AG
RRFGGYGFGSSS------------------------FGGGRFGGSHHG----GGGLGAAG
--FG-AINLGSSGFG------------PSY-AP-GG-I-HE-VT----------IN-E-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TR-E------------------------------
------R-EQL-MV-LN-NK-FA-AFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---SV--RTNNLETFFESYISELQRK----VDVLNAER
-----------MRKAS-----EIKSMEDVVEDYKN--KYEEEINKRTNTE--NEF-VVLK
KDVDA----AYM-NKTDLESKADTLF---EEVNFLKYLFEMELS-QM-QTHISDTNVIL-
-SMD-------------------NNRTLDL--------DSIIQAV-QAEYELIIQRSKNE
AETLYQT---------K----YQEL-QI-SAGRHGD-DLKNTKM--------------EI
SELNRNIQRMQAE--I---------ASVKKQ-----------------IEQAHS----AI
SDAEERGDRALQDAKQKLQDM---------------DEALQHSKENLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LECEELR------------MSGELQNQV--S---------ISVQ----------------
-------SSQ----------------------------VTMSGSGGGGGGS-----G--G
-------------------------------------------YGGGSYSSGGGSSGGQG
S-------------H---------------------------------------------
----------------------------------RGSGG-------------------GY
AS---GSGGGS-YGASSR-S--------------SSK-----------------YRGGRS
S----GGGGSSRV-------QIIQT-STN-------------------------------
---------------------------------------------------------SSR
RRFVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGGGGG----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GFGG----FGSG-GGG--FGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GSSYGSGGGSYGSG------
---GGGGGG------GRGS-----------YG----------------------------
-SG---GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCKSRRGGGG--GGGG---------------------GFRGFSSGS--
AVVSGG------SRRSTSGFSC--LSRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISSSVAGYGGG--FGGRSY-G---GFGG------------GSGFGGSGGFGGGSGFGGG
RGFGGG----SG----FGGG-SGFGGGSGFGG-GSG-----FGGGGFGG----GRFGGGP
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DT-VRF-LE---------------------Q-
QN-QV-LHT-KW-EL-LQQLDV---GT--RTTNLDPVFQAYIGILKKQ----VDRLTAER
-----------NSQDS-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NDF-VTIK
KDVDS----CYM-DKTELQAKMEMLT---QEVDFLRTLYDTELS-QL-QQNVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QSQYEIIAHKSKAE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHAIKDARGKLTDL---------------EEALQQGRENLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDFS--DNVS---------VSVT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GG------------------------R-GGG--STYGSGGRSSG------VR
G-SGSGSG-GGGYSSGGGS--RGG------------------------------------
-------------------------------------SGGGGYSTGGGSRGGSSSGGGGY
SSGGGSRGDSSSGGGS-----------------------R-----GG-----SGG----G
S----RGGSG-------------------------GGGYSSGGGSRGGSS------SGGA
VSGSERGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MELEGKLESLR---ELFCFLTHLYEEERS-QL-QTQAGDTSVVV-
-SMD-------------------NNRCLDF--------SDIIAEV-RSRYEEIACTSKAE
AEALYQT---------K----YQEL-QS-SAQLHED-SMKETKI-------------Q-V
SQLQYEIQKLQSQ--I---------DSLKRQ-----------------NADMQS----AI
NDAQQHGELALKDAKSKLDEL---------------EGTLRMAKQDMARL-------LR-
------DYQELTSTK-------------------------------L-SLDVEIAMYRRL
LEGEENR------------MSGECPSQVIIS----------------I--VGD-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NAIVPGGVGGSQQRGTCGFRGGKDTFGY-GCSSVV
TGGFSDTLGSG---------------------QGPTSGSCSVSGSGFSSGSSSSSSHHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGGGLR----------------------------ISHGYTSSA--
VALPGR------SKGSFSSIS---LSQSGRGN----------------------------
----------------------------------LGVGLGDGFGSRSLYSLG-GN----K
RTSLYVGGSGGGFLVG--GFGTGGGG---------------GGGYGGGG------GYGGG
GGYGGGGFGSGG----FGVG-G-YGAG-------------GYGPGGYGL-------ALGG
--GGLGGGGG--RMA------------PIV-PP-GG-I-QP-VS----------VN-P-S
L--LAP-LN-LE-FD-PE-IQ-KVR-VK-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KL-NL-LQQQGS---TA--TTIHIDPMFEAYINNLRNQ----LDGLVGDR
-----------GRLDG-----ELRNTQDLVEDYRK--RYEDEINKRTTAE--NEF-VDIK
KNVDG----GFM-HKIELGAKADGLT---DEINFLRALHEAELS-QI-QGRISDTNIVL-
-QMD-------------------NNRDIDL--------NSIISEV-KAQYEDIANRSRAE
AEALYQS---------K----FQEL-QS-TAVNHGD-DLKNTKN--------------EI
AELSRIIQRMKAE--I---------DNVKKQ-----------------IAGLQT----AI
ADAEQRGELALKDARVKLTDL---------------QHALQSAKDELARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRTL
LEGEECR------------MSGELT--TPVS---------MSVI----------------
-------SSS----------------------------SSIGGSSYGIGGLGGGG--GGG
RVSS-----------------------------GGFGLG------TGG------------
----GGGG-GSGGGGGGLG--------------------------------------LGI
G------------------GGGGGGYGVSSGIAT----GGRSY---------SSGSARGF
GGGL-----------------------TA---------------------------GGGG
A----GGGGSSSS--T----KYVST-TSSSS-----------------------------
------------------------------------------------------------
---------------KKIVR----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MASC----QATG------------------------------
-----------------------------------YRV-GAGFSSRSLYSLG-GN----R
HISFDVAGG--SAR-AT------------------------ELRFGHG------------
-----------------------------------------------------SGYGGTR
TSGFASSMFGSVDTG-PT---CP----FMCL-P-GG-I-HH-VI----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LNT-KW-EL-LQQLNL---NS--CKGSLEPVYEAHISSLRKK----LEMLSGDR
-----------VRLDS-----ELRNMRDMVEDYKK--RYEVEITQRTAAE--NEF-VLLK
KDADA----AYM-VKVELQAKVDSLE---KDIKFLKCLYDAEID-QL-QTHVSDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEDIALKSKAE
AEALYQTK-------------IQEL-QL-AAGCQGD-NLKHTR--------------NEM
LELNRLIQRIRRD--I---------ANVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------EYQELMGLK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSY------------
------------------------------------------------------------
-----------------------------------------GSYG-YHP-----------
-----------------SS-------MSSDFGA---------------------------
----GNAT-------------------------------------------GSPSTTR--
--------NSQTKTRGARAT-----ELR-------NSQ---NKS------TA--VGSPAK
-KTT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFSSRSAFSSRS----------------------------RRVYSTSS--
---------------------------SSGY-GGG-------------------------
---------SRAVGSVCHAWGRCGG--------GGYRGHGMGFGSRSLYNLG-GS----K
SISISLVGRSPSG--FRQGGGA-------------------GGGFG------------GA
RGF---------------------GGG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--WSNNLEPVLENYIRDLQRQ----VDFLHAEQ
-----------MRQNT-----EARSMQDAVEDYKN--KYEEEINKRTNSE--NDF-VVLK
KDVDA----AYM-NKVDLQSKVDTLL---GELDFLKYFFMTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RMQYELIAQKSKDE
AEALYQT---------K----YEEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------GNMRKQ-----------------VDHMQS----AI
SDAEERGERALQDAGQKLQDM---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEEIR------------MSGELQNQV--S---------ISVQ----------------
-------NSQ----------------------------VTTGGSS---GGY-----SSGG
-------------------------------------------YGSGG-YSTGGYSGGGS
R-------------R---------------------------------------------
---------------GGG------GSYGAGGSR-GGSGG-------------------GY
GSG---SS-GA-YGGGSGK-----------------------------------FGSGSG
R----SGRS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
KRVLE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISNTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRQSYSIRAGSGGGS--------------------------AGKGFSTAS--
AIIPSA------NRSGFSSLS---LARAGGGGLGG-------------------------
---------GGGL-------GRITI--------GSGGGGGGGFGSRSLYGLG-GA----K
RISVSRS--SNLRSGFGAGGGGGF-GFGS----------GSGSAFGF----------G-A
I----AG-GS-------GF---GFGGGGGGG-------GG----------------GGYG
---FGFGGGV----I--------------P-GG-GT-I-QE-VT----------IN-Q-S
L--LAP-LN-LE-ID-PA-IQ-EVR-KE-E------------------------------
------K-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-TL-LQDQGF---KTGANKGNLDPLFEAYINNLRKQ----LNGLINEK
-----------GRLDG-----ELRNMQDIVEDFKT--KYEEEINRRTSAE--NEF-VMLK
KDVDA----AYM-NKVELEAKVDSLT---DELNFLRALYEAELA-QL-QAQMSDTAVIL-
-SMD-------------------NNRDLDL--------NGIVSEV-KAQYEDIANRSRAE
AEAWYQT---------K----FEEL-QA-TAGRHGD-DLRNTKG--------------EI
SELNRLIQRIRAE--I---------ENARNQ-----------------CANMQT----AI
ADAEDRGELALKDARAKLIEL---------------EEALQKAKEEMTRL-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEESR------------LFGEGV--NPVS---------ISVV----------------
-------STS----------------------------A----GGGGG------------
--G-----------------------------------------------G---------
-----GGL-GGG------------------------LGGGL------------GGLGLGL
GGGGFGLGSGLSFGGGGGSLGSG-------------L--------SFGYGG-GSGGGLGF
G--G----GS--FS----------SGSGKG----IGA-----------------------
--------GSSSG--VK----IISK-TSTSQKSIKS------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--G-GGG-----------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MPLSP----CRPQR---GFSTRSA-----------------------------------
----------------CCTRSRG----CS-SV---------GFSSRSLNSFG-EC----L
G-GS-HR-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-QS-G-G-PG-L-S-----L-CP-P-GG-I-QK-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGRPQGLEPVFEACLAQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYQEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYICFLKRLYEEELA-QL-QTQDSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGN-SIQETKV-------------Q-I
SQLRQEIQRLQSQ--I---------ENLKKQ-----------------NASLQG----AV
ADAEQRGELALKDAQAKVDEL---------------EAALRMAKKNLAQL-------LR-
------EYQELMSMK-------------------------------L-SLDVEIATYRRL
LESEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVVSGGVGGGL-GGTCGLGGGKGSSGS-RCTSVV
TGGSSILLGSG---------------------KDPVLGSRSVSGSSSGS------SCHTI
LKKTVESSLKTSTTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CFAGSRG----RS-KG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPIFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEEPG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RAQYEEIARTSKAE
AEALYQT---------K----YQEL-QM-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVDEL---------------ESALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGSL-GSTCGLGGGKGSSGS-CCTSIV
TGGSNIILSSE---------------------KDPVLGSCSVSGSSSAS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--MSTKTTIKSQT--S----------------------------------HRGYSASS--
ARVPGL----N--RS---GFSSVSVCRSRGSGGXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXLFELICVSLCQSRGI---------SGSGPMYRVASFGSRSLYSEG-SS----K
REASIGGSSCGNREFYG-------------RHYGGDLG------IGRG--------A---
------------CGC-FGFGA-G----A-------------------------------G
---FGGGYGGA----------GF----PGYP-S-GG-I-QE-VT----------IS-Q-S
L--LIP-LN-LQ-ID-ST-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-AL-LQEQGT---KS--VKPEVETLFEDYINILSRR----LGFTVAEK
-----------CHLDA-----ELRRSQGVLEDYKY--KYEDEISKRTAAE--NEF-LTLK
------------------------------------------------------------
----------------------------------------------KTQYENIAKKSQAE
AESWYQT-------------KYEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDARGKLEGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGE------------------------G--VGPVNIS---
------------------------------------------------------------
----------------------------------VVQSTV-S--SGYGSAGGA-----SS
---------------------------------SLGVG----------------------
---GSSS--YSYGSSHGLGG--------------------GFSAGSG-------------
-----------------RAT--G-GGL--------SSS----------------------
-----------------------------------------------V-GS---------
---------------------------------------------------------SST
IKYTT----SASSSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------SNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GG----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CKNNLEPILEGHISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDTMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYS------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGENRSR-GSAS-----DYK-------DTL---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--MSTQTMIKSQT--S----------------------------------HRGSSASS--
ARVPGL----N--RS---GFS---------------------------------------
------------CVSLCQSRGI---------SGSGPMYRVASFGSRSLYSEG-SS----K
REASIGGSSCGNREFYG-------------RHYGGDLG------IGRG--------A---
------------CGC-FGFGA-G----A-------------------------------G
---FGGGYGGA----------GF----PGYP-S-GG-I-QE-VT----------IS-Q-S
L--LIP-LN-LQ-ID-ST-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-AL-LQEQGT---KS--VKPEVETLFEDYINILSRR----LGFTVAEK
-----------CHLDA-----ELRRSQGVLEDYKY--KYEDEISKRTAAE--NEF-LTLK
KE----------------------------------------MS-QI-QTPLSDTSVII-
-SMD-------------------NNHSLDM--------DSIIAEV-KTQYENIAKKSQAE
AESWYQT-------------KYEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDARGKLEGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGE------------------------G--VGPVNIS---
------------------------------------------------------------
----------------------------------VVQSTV-S--SGYGSAGGA-----SS
---------------------------------SLGVG----------------------
---GSSS--YSYGSSHGLGG--------------------GFSAGSG-------------
-----------------RAT--G-GGL--------SSS----------------------
-----------------------------------------------V-GS---------
---------------------------------------------------------SST
IKYTT----SASSSRKSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------LSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RLALSS-----AGR-SG------------------------GFTLGHG------------
------------------------------------------------------GASGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--SKRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKVLFEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILAEVR-AQYEEIAVKSKAE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKHTK--------------SEI
TEINRLIQRIHSE--I---------GNMKKQ-----------------CSNLET----TI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MAGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGAS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPP---AKT-------S--GSSGTT
KKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCKSR-R-GG--GGGG---------------------GFRSFSSGS--
AVVSGG------SRRSTRSFSC--LSRHGGGG----------------------------
-----------------------------------GGAGGGGFGSRSLVGLG-GT----K
SISISVAGGGGSFGSGGGFGGRGG-GFGG------------GSGFGGGS------GFG--
-GGGF-----G--------G-GGFGGG-------SGFGGGGFGGGGFGG----GRFGGGG
--GLGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-E-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---ST--RTTNLEPIFQAYIAKLKKY----VDTLSAER
-----------TSQGS-----ELNNMQDLVEDFKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----TYM-TKVELQAKTDVLT---QELEFIKFLFDAELS-QM-QTQISETNVTL-
-SMD-------------------NNRSLDL--------DSIISEV-KAQYEEIAQKSKAE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEVKM--------------EI
SELNRMIQRLQGE--I---------AHVKKQ-----------------CKSVQE----AI
AEAEQKGEHAVKDAQGKLSDL---------------EEALQQAREDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SSS----------------------------MSSSMTSRGGF-GG-YG--SGG
RGS---S--SG---------------------GGGFSSG-SGSYSSGGRGSS------SR
G-G--G-G--GGYGSGGGS--GGK------------------------------------
-------------------------YSSGGGS----------------------------
---------------RG--------G---------------------------SGSGGGY
G----SS---------------------------SGGGYGSGGGSRGGFS------SQK-
----------GGSG---------S---------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
QDVDA----AYM-NKVELQAKADSLT---DEVNFLRTLYDMELS-QM-QSHVSDTSVVL-
-SMD-------------------NNRCLDL--------DSIIAEVR-AQYEDIAQRSKAE
AEALYQTK-------------LGEL-QT-TAGRHGD-DLRSTK--------------SEI
MELNRMIQRLRAE--I---------ESVKKQ-----------------NSNLQT----AI
AEAEQRGEMALKDANAKLQEL---------------QAALQKAKDDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVCRISS--
---------------------------SAGS-GGG-------------------------
---------SRGVGSVCQARGKCGG--------GGYGIHERGFGSRSLYNLG-GS----K
SISISLVGRGASG--FRQSRGI-------------------GGSFG------------GG
RGF---------------------GGV--------SFRSG-----GFG----GGGFGGAG
--FG-ASNFGLGGFG------------PPC-PL-GG-I-QK-VT----------IN-Q-S
L--LEP-LN-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--QSSNLEPLLQNYISQLQRQ----VDFLNKEQ
-----------MRQNT-----EVRSMQDLVEDYKN--RYEDEINKRTNGE--NDF-VVLK
KDVDA----AYM-NKVDLQSKVDVLA---GEVDFLKYFFETELS-QI-QTHISDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RIQYELIAQKSKDE
AEALYQT---------K----YQEL-QV-MAGRHGD-DLKNSKM--------------EI
TELNHTIQRLQAE--I---------SNMKKQ-----------------NDQMYS----AI
SDAEERGEQALQDARQKLQDM---------------DEALQQAKEELARL-------LR-
------DYQAILGAK-------------------------------L-SLDVEIAMYRQL
LEGEESR------------MSGELQNHV--S---------ISVQ----------------
-------NSQ----------------------------VTVSGAGGGGGSY-----GSGG
-------------------------------------------RGSGS-GGG--Y-----
G-------------S---------------------------------------------
---------------GGG------GYGSGGGSR-GGSGS-------------------GG
GHG---SGGGS------GGK----------------------------------YGSGGG
S----KGGS---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGS------------------------------DKGNFSVHS--
AVLP-RT-------AMGSLASY----RVAG------------------------------
-----------------------------------TGA-GAGFSSRSLYNFG-GN----R
RLSLNLAGG--GVR-AG------------------------SYSFRHG------------
-----------------------------------------------------SGYGGGR
PSGFAGSMFGSVALG-PA---CP----SLCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LKQLDL---NN--CKKNLEPILEGYISGLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEISRRTAAE--NEF-VVLK
KDADA----AYA-AKVELQAKVDSLD---KDIKFLKYLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRSLDL--------DSIISEVR-VHYEDIALKSKAE
AEALYQTK-------------IQEL-QL-TASRHGD-DLKHTK--------------NEM
SELNRLIQRLRCE--I---------GNVKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ICEYSHLEG---GK------
-------------------------------------------AGDLGTKLG--------
-----------------------------------VGFSHSGSYG-YHP-----------
-----------------SS-------TGADLGA---------------------------
----SGVV-------------------------------------------GSASSIR--
--------SGQTKTKGAQGG-----DFK-------DSQ---SKS------IP--ASTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSVRSGG----R------RS---RGSFSSRSLSSSR-GC----P
G-GS-RG-----------------------------------------------------
-----RTWGSGG--R-LG-V---------------------------------R-F-G--
-------E-GS-G-R-PG-F-S-----L-CP-P-GG-I-QE-V---------T-ID-P-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TK-E------------------------------
------TR-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGSPQDLQPAFEAYLAQLRKQ----LEQLQRER
-----------GALDA-----ELKACRDQEEEYKA--KYEEEARKHATAE--NDF-VVLK
KDADG----VFL-SKMELDGKLAALR---EHICFLKRLYEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NDRCLDF--------SDIIAEV-RAQYEQITQTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-SMKETKV-------------R-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NADLQA----AI
AGAEQRGEAALKDAQAKLDEL---------------EAALRAAKQDLARL-------LL-
------DYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGEYTSQVTVS----------------V--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGSL-GGSGGLGGGKGSFGS-YCSSIV
TGGSSATLGSE---------------------EGPVWGSCSVSGSRSGS------SSRTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGF---------GG-------G-GF----GGFGSGGGGGGGFGG----GGFG-GG
--------GYGGGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-LE-VD-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFEAFINNLRRT----VDQLKNDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-AKVDLQAKLNNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IGNLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGGYSSGGGSY-GS----G-
---GGGGGGGGSYGSGGSS-----------YG----------------------------
-SG---GGSYGSGG-GGGGHSSYGSGSSSGGHRGGSGG---------------GGRGS--
------GGGSSGGSSGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAGGSVCYTRGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FRHGGGV-------------------G-GFG------------GV
RSFGV-----------SS-----IGAG--------GFGGG-----GFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYISDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNCTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGSGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-RGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSGR
S----SGGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQM---GFSARSA-----------------------------------
----------------CSAFSGA-----------RG---RTGFSSRSLSSSG-RC----R
G-SS-CG-----------------------------------------------------
-----RAWGAET--R--------------------------------------R-F-G--
-------Q-GK-G-G-PG-F-A-----Q-CP-P-GG-I-QA-V---------T-VD-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TR-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQR--L---QGNHSPQGLECIFEACLARLRQQ----LEELQRER
-----------RALDS-----ELKTYQDQEDEYKS--KYDQEANKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGNLESLR---EHVCFLTRLYEEELG-QL-KTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITRMSKAE
AEEVFQT---------K----YQEL-QE-SAQLQGN-SMKEAQV-------------Q-I
SQLRQAIHRLQSQ--I---------GSLRKQ-----------------NDSLQS----AI
ADAEQQGEMAVRDAQAKLDEL---------------EAALRTAKQDMAQM-------LR-
------DYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISKEHTSQVTVS----------------I--TESGIVP---
---GRTCGGQ-----------------VTVP-------------------G---------
RE----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-YGGQVTVPGREYGGQVTMPRGECGGQVTVPGGEYGGQVTVPRGXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
------------XXXXXXXXXX---------------------X---------X------
-----------------------------------------------------------X
XXXXXXXXXXXXXXXXXXXXXXXX------------------------------------
--------XXXXXXXXXXXXXXXXXXXLEA-RGECGGQVSTCGHRGWQGSFGSGGCSSIV
TGGFEIPQGSG---------------------YSPTMGSCSVSGSGFSSGS--GSSCRTI
LKKTVESSRKMSVIY---------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRTQR---GFSARSA-----------------------------------
----------------CSAFSGA-----------RG---RAGFSSRSLSSSR-RC----R
G-SS-CE-----------------------------------------------------
-----RVWGAEA--R-QG-L---------------------------------R-F-G--
-------R-GS-G-G-PG-L-S-----Q-CP-P-GG-I-QA-V---------T-VN-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLEPIFEACLARLRQQ----LEELQRER
-----------GALDS-----ELKTYQDQEDEYKS--KYDQEAHKHALVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGKLESLR---EYVCFLTRLYEEELG-QL-QTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITQTSKAE
AEAVFQT---------K----YQEL-QA-SAQLQGD-SMKEVRM-------------Q-I
SQLRQTIQKLQSQ--I---------SSLKMQ-----------------NGTLQS----AI
ADAEQHGEMALRDAQAKLDEL---------------ETALRTAKQDMAQM-------LR-
------EYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISKEYTSQVTVC----------------E--YEGPLRV---
---GLPCGAEGL--------------VVTLV-------------------L---------
-SWQ----------PRVVVP--------GGVGGGQVVI-------PGRIGGGQ-----MI
VPGRIGG----------GQVVIPGRINGGQ------------------------------
------------------------------------------MVIPGRVDGG--------
----------Q-KVIPGRVD--G-GQVVKPGEDCRGQMVKPGGVDGGQMVIPGRVDGGQM
VIPGRVDGGQMVIPGRVDGGQK-----------VIPGIVDGGQM----------------
-----------------VMPGGIDEGQVIVPGEDCRGQMAMPRGDCRGQN----------
----------------------------------------------------------VI
PGRVDGGQMV-----------MPGGDCRGQIVMSGGDCGGQMVMPGGVDGGQMVMPGGDC
RGQMVIPGGDCRGQMVMPGRDCGGQNFIP-----------GRVDGGQMVIPGGDCRGQMV
MSGGDCGG----------------------QMVMSGGDCGGQMVMSGGDCGGQMVTP---
-------------------GGDCRGQMVVP-G---GVGDGTCGLRGWKGSFGSRGCSSIV
TGGFDVPQGSG---------------------CSPSMSSCSVSGSGFSSGS--GSCCRTI
LKKTVESSRKTSVIY---------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSLQCSSRSLCRSGGG--------------------------G-RNFSSGS--
AGLVSF------QRRSTSCSM----RRSGGGGGG--------------------------
---------RFSGG------GFCGSS-------------GGGFGSKSLMNLG-GG----R
SISKSVAGGGG---SFCGGGFGG----G---------------SYGGG------------
-GFGGGSYGGGG----FGG-------S-GFGSFG----G-----GGFGS---GGGFG-GG
--GYGG-GRF-GSMG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PQ-IQ-KVK-SQ-E------------------------------
------R-EQI-KS-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTQNLDPYFESYISNLRRQ----VDSLKSDQ
-----------SRMDS-----ELKNMQDMVEEYRT--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVELQAKVDALQ---QDIDFLSALYQMEMS-QM-QTQVSETNVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYDSICQRSKAE
AETFYQS---------K----YEEL-QV-TAGKHGD-SVRNTKM--------------EI
SELNRVIQRLRSE--I---------DGCKKQ-----------------ISHMQQ----NI
SDAEQRGEKALKDAQNKLNEI---------------EDAMSQCKEDLARL-------LR-
------DFQELMNTK-------------------------------L-ALDMEIATYKKL
LEGEEI R------------MSGECT--PNVS---------VSVSTSHT------------
---------------------------------------SMSGSSSRG--G---------
-------------------------GGR--------YGG-GGSGGSYGG-GS-----GGG
SYGGGSGG---------GS-----------YG----------------------------
-GG-SGGGSY--GG-GSGGGSYG--GGSSGSHRGGSGGGGG-------SSGGSYGGSS--
------GGGRGG------SSS------------------------------------GGG
V----KSSGSSTV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GTK-------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQALVSVSQ--SRRYGGDY-----------GGGFSSRSLYSLG-GS----K
SIFGYLVGRSASG--FCQGRGP-------------------GGGFG------------GG
IGGGI------------GGG-RSFGGG--------GFGGGYGGGGRFG-----GGFG---
-----GAGFGLGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFEEFISQLQRQ----VDVLTTEQ
-----------LRQNT-----EIRNMQDVVEDYKN--KYEDEINKRTNAE--NDF-VVLK
KDVDA----AFM-GKSDLQSRVDTLY---GEINFLKYLFDTELS-QI-QTNVSDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RAQYEIIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-EVKNSKM--------------EI
SELNRNIQRLRAE--I---------ASIKKQ-----------------IEQMHG----SI
SDAEERGERALQDAKQKLQDL---------------EEALQQSKEDLAKL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGALQSQV--S---------VSVQ----------------
-------SSQ----------------------------VTIGGGGGGLGGY-----SGSS
-------------------------------------------RGGGG------------
------------------------------------------------------------
-----------------------SGGGT--GSRGG-------------------------
--------GGS-YVSS-SRS--------------SSKYRS--------------------
------GGGSSRT-------QILQT-STH-------------------------------
---------------------------------------------------------SSR
RHVVE-------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MNRQFTCKPGAA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-SP----R
SISFNVASS--GGR-TG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGAVG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--CRRNLEPVYEAHISSLQKQ----LDSLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIT-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------ERALHQAKEELARM-------LR-
------EHQELMSMK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTP---G-------
---------------------------------------------TVGAGTS--------
-----------------------------------FGFSSTGTYG-YRQ-----------
-----------------SS-------VAGGYGI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-DTKNRLGSAS-----EFK-------EVS---GKT-------L--ALGSPS
KKTMR-------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQLN-FRPGG------------------------------DKGSFSVLS--
AVVP-RK-------ALGSMASY----RASG------------------------------
-----------------------------------QGV-GASFGSRSLYSLV-GN----R
HISFNTAGS--GIR-AG------------------------APSFGHG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PK-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKSLEPIYEGHISSLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--KYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKVELQAKVDSLE---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIITEVR-AHYEDIALKSKAE
AEALYQTK-------------IQEL-QL-AAGRHGD-DLKHTR--------------SEM
SELNRLIQRIRCD--I---------TNVKK-----------------QCSNLEM----VI
ADAEQRGDSALKDARDKLDEL---------------EGALHQAKGELARL-------MR-
------EYQELMSLK-------------------------------L-SLDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSNS------------
------------------------------------------------------------
----------------------------------------YGSYG-YNP-----------
-----------------SS-------ASADLGA---------------------------
----GSVA-------------------------------------------GSPSSPR--
--------SGQIKSRGGRGG-----DHQ-------ESQ---EKS------VP--ASMPAR
-KTTR-------------------------------------------------------
------------------------------------------------------------
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MASTSTTIRSHSS--S----------------------------------RSGLQCGS--
ARLPGQ----G--SC---GL----------------------------------------
----------------------------------MAHVEEAGFGSRSPVWAW-G-----L
QEDPIGGGSCAISGGYG-------------NRTGGSMA------LVAG------------
----WLGFVVEPGIG-FGLGG-G----A-------------------------------G
---LAGGLLGA----------LA----SCVA-----------------------------
--------------------------PW-S------------------------------
------A-SRS-RT-LN-NK-FA-SFI-DK-VSQ-GH---------------------Q-
QN-KV-LEP-SG-PC-CRSRAT---KD--READLEPCIEQYINNSEAAGQHRRG------
------------NRDQ-----T---CRTWVEDLKN--N----------------------
-------------------ARQTLFT---DEINFLE---IRRLH-HS-FLHISDTSVVL-
-SMD-------------------NNRQPGP--------GQHYRRG-QGQYEKICQRSRAE
AE--FLT-------------RYEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGE------------------------G--VGQVNIS---
------------------------------------------------------------
----------------------------------VVQSTV-S--SGYGGASGV-----GS
---------------------------------GLGLG----------------------
---GGSS--YSYGSGLGVGG--------------------GFSSSSG-------------
-----------------RAI--G-GGL--------SSV----------------------
-----------------------------------------------G-GG---------
---------------------------------------------------------SST
IKYTT----TSSSSRKSYKH----------------------------------------
------------------------------------------------------------
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-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYLSNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--KYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGEAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQ--------------------------------------------SVC--
RSFAVG----G--RK---GFSSCSAVGGGFGGGGGRSK----------------------
----------ISYSSYS-----------S-SRGGGGGGHCGGFSSRSVHGVG-GS----R
GVAVGGC--------YGGGYGGRMGGFGGGMGCGGM---------AGG------------
-GMGMGGFGG----------G-M---GGGGG------------M---------GGFGGGM
GSGGMGGM---GGF--------G----GPGF-P-GG-I-QP-VQ----------VD-P-S
L--LRP-VH-VE-ID-PQ-IQ-QVK-NQ-E------------------------------
------K-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LST-KW-EL-LQQQG----PSG-PRKNLDVIFENYIQNLRRQ----LESILAQR
-----------GQLES-----ELQNMRQYVEEFKT--KYEEEINRRTAAE--NEF-VVLK
KDVDC----AYM-TKVELEARVGALT---DEINFLRCIYEEV-G-AL-PSPG--------
------------------------------------------------------------
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-MSLSP----CRAQR---GFRARSA-----------------------------------
----------------CSSPSGG-----------RS---RGGFSSRSLSPFG-RC----P
G-GS-RG-----------------------------------------------------
-----RAWGSGR--R-LG-A---------------------------------Q-L-G--
-------E-GS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-S
L-L-TP-LK-IE-MD-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-QL-LQQ--L---GMSGGPWGLEPVFEGCLAQLRRQ----LEQLQGER
-----------GPLDA-----ELKACRDQEEEYKD--KYKQEAHRRATLE--NDF-VVLK
KDADG----VFL-SRMELQAKLETLR---EYICFLKRLYEEELH-QL-QTQVSDTSVVL-
-SMD-------------------NNRCLDL--------DGIIAEV-RARYEEIARTSKAE
AEALFQT---------K----YQEL-QV-SARFHGE-SMKETKA-------------Q-I
SKLRHDIERLQGQ--I---------ESLKGQ-----------------NANLQS----AI
ADAEQRGGLALKDAKNKLDEL---------------EAALRAAKQDMARQ-------LR-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LEVEECR------------MSGECTSQVTIS----------------T--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------SAVVSGGVDGGL-AGTCGLRGRKGGFGS-CCSSIV
TGGSNVTLGSG---------------------KGPELGSCSVSGSGSSS------SCHTI
LKKTVESSLRTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRAR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------ESALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQLNLY-PGG------------------------------ERLAFSGCS--
AIIS-SR-------VSSSTASV----RASG------------------------------
----------------------------------VK-----------LLNGG-GG----R
RLALSST----AGR-GG------------------------SVLGPCV------------
------------------------------------------------------ATGGGR
RGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VT----------I-NK-S
L--LSP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQLDL---NN--CKNNLEPILEGYTSNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFLKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAQVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SDLNRMIQRIRSE--I---------GNVKKQ-----------------CSNLEM----AI
ADAEQQGDCALKDARAKLDEL---------------EAALLQAKEELARM-------MR-
------EYQELMSTK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTSA---G-------
-------------------------------------------AGGTGFSMG--------
-----------------------------------FGAS--SSYS-YKSS--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-GS-----ELK-------DAP---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
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-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--SRKSLESIYEARISTLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---EEIKFFKDLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRQLDL--------DSIIDEVR-AQYEETTQKSKAE
AEALYQGK-------------IQEL-QV-AAGQHGD-DLKLTK--------------TEI
LELNRLVQRIHSE--I---------GNVKKQ-----------------CSSLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------DHQELLSVK-------------------------------L-ALDVEIATYRKL
LEGEESR------------MSGEFPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFNVG--------
-----------------------------------FGTS--SSYS-YKPV--------A-
-----------------ME-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-G------ELK-------DPL---AKT-------S--SSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--SVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYAGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKMDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---CP----SLCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLHS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------MAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFR-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRMCFSAGSLG------------------------------GRRCFSSAS--
AICS------------------------LGGGRA--------------------------
-----------SVGAGPW--------------PA-GRRENGGFSSTSVFELG-RS----Q
RISCGGGYGIGPCGPYGAGGYGYGAGHGS-------------------------------
----GGGFAYGSCVG-SGR--GGYRGPCGFGG---------YSP---------YHFGSSV
H--YG---VGHAGA--------G----GAHR-A-DG-I-QG-VC----------IH-P-E
L--LKP-LS-VG-VD-PE-EH-KVR-TH-E------------------------------
------K-EQI-KC-LN-DQ-FA-CFI-DK-VRC-LE---------------------Q-
QN-KV-LAT-KW-EL-LQRHAV---PP---RRDLVPIFENYICQLKKH----LEGLVHER
-----------ARLEE-----EEKTVQDAVHEYKC--KYEEEINKRTHAE--NEF-VVLK
KDVDC----VFM-TKEDLEAKLLQLR---QHLEFLKCIFLEERA-QM-DGQLCDTAIVL-
-EMD-------------------NNRNLDL--------SGIIHSV-KCCYEEIAQRSKGE
AEAFYQT-------------RLEEL-ST-NRGRFCD-DLKTIQG--------------EI
TELKHVIHKLQGD--T---------DKVKKE-----------------IACLQT----AI
ADAEQRGDLALKDAREKHIDL---------------QNALQQGKDKLACM-------LR-
------DYHEMLNVK-------------------------------M-ALDIEIATYRTL
LEGEETR------------ICTGNP---------------ANVAVVSG--GHPVGDCRPP
FGA--PCG-HL------QR---GFSH---GPGVF---------AATDGFSA---------
QSAE----------GIARMG--------GSYGARTVVCSSGRGFNVGGA-----------
-----------------GS-------CGVGYGMGGFS-----------------------
---SGSGGCSY--RRVLSSEVSGAGGEAGS---------HS---VGGP---GSVG-----
-------------VVCGSGE--A-AA-------C--------G-----------EGAG--
-----NVGG-------AHS---AMEHFGTGGVGSLSGGIHS-----SGGAY---------
---------------------------------------------------------SSG
MRMVSVSC-GRKILR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSASP----LRAQR---GFSALSA-----------------------------------
----------------CSTHPRN----S-----------WGGFSSRSFTSSG--C----R
A-AT-RE-----------------------------------------------------
-----GPWG-GG--R-QG-L---------------------------------Q-S-G--
-------G-PM-G-G-LG-S-S-----L-CP-L-EG-I-QE-V---------T-IN-Q-S
L-Q-TP-LK-IE-ID-PQ-FR-AVG-TQ-E------------------------------
------TR-EI-RT-LN--Q-FA-SXX-XX-VRF-LE---------------------Q-
QN-KF-LET-KW-AL-IQQ--Q---GQSHGPRNLESYFESYLAQLRRR----LEELQRDR
-----------GALDA-----ELKSCQDQEEEYKA--KFEQEAQRRTTVE--NDF-VVLK
KDTDE----VFL-RKMELEDQLESLR---VHTCFLRRLYEEXXX-XX-XXXXXXXXXXX-
-XXX-------------------XXXXXXX--------XXXXXXXXXXXXXXXXXXXXXX
XXXXXXX---------X---XXXXXXXXXXXXXXXXXXXXXXXX-------------XXX
XXXXXXXXXXXXX--X---------XXXXXX-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXX-------XX-
------XXXXXXXXX-------------------------------X-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXX--XXXXXXX---
---XXXXXXXXX---------------XXXXX----------------------------
-------------------------------XXXXXXX-------XXXLGSG--------
--------------------SSSSSVCHTILKKTV-------------------------
---ESS----------LKTSVTY-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---TSY----RAGG------------------------------
-----------------------------------KGL-GGAFGSRSLYNLG-GT----R
TISLN-------G-RS--------------------------------------------
-------------------G--------------------------------GYGFGRGR
ASGFAGSMFGSVALG-PT---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LEP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGFISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDNKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVXXXX---XXXXXXXXXXXXEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLNL--------DSIIAEVR-SQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKK-----------------QASNLET----AI
ADAEQRGDNALXXXXXXXXXX---------------XXXXXXXXXXXXXX-------XX-
------XXXXXXXXX-------------------------------X-XXXXXXXXXXXX
XXXXXXX------------MSREFPSPVS-----------ISIISST-------------
------------------------------------------------------------
--------------------------------------SG----G-FRP-----------
-----------------NS-------VSGGYVA---------------------------
----NSTSCIS-----------G------------------------------VCSVR--
--------GGESRGR---TG-----DYK-------DAL---GKG------S---SLSVPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQALVSVSQ--SRRCGGDY-----------GGGFSSRSLYSLG-GS----K
SIFGNLVGRSASG--FCQSRGP-------------------GGGFG------------GG
IGGGI------------GGG-RGFGGG--------GFGGGYGGGGRFG-----GGFG---
-----GAGFGPGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KI-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFEEFISQLQRQ----VDALTTEQ
-----------SRQNT-----EIRNMQDVVEDYKN--KYEDEINKRTNAE--NDF-VVLK
KDVDA----AFM-GKSDLQSKVDTLY---GEINFLKYLFDTELS-QI-QTSVSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RAQYEIIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNIQRLRAE--I---------ANAKKQ-----------------VEGMHG----LI
SDAEERGERALQNAKQKLQEL---------------EEALQQTKEDLAKL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGALQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTIGGGGGGSGGY-----SGSS
-------------------------------------------RGGGG------------
------------------------------------------------------------
-----------------------GGGGT--GSRSG-------------------------
-------GGSS-YVSS-SRS--------------ATKYGS--------------------
------GGGSSRT-------QILQT-STH-------------------------------
---------------------------------------------------------SSR
RHVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AXXXXXX-------XSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCMG-GG----R
RLALSS-----AGR-SG------------------------GFALGHG------------
------------------------------------------------------GASSGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-CFI-DK-VGL-EA---------------------E-
TC-G------------GTVGHV---NN--CKRSLEPIHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVDLQAKVDSLT---NDIKFFKVLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRQLDL--------DSILTEVR-AQYEEIAVKSKTE
TENMYQCK-------------IQEL-QA-TVGQHGD-DLKLTK--------------TEI
TEINRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MNGDYSHAVS-----------ISVISNTNA---G-------
-------------------------------------------PGGSGFNVD--------
-----------------------------------FGSS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DSP---AKT-------S--GSSCST
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISSSLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGV-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSSR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------SKGGFSGCS--
AVLS-GV-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-GGGFSSRSLYSLG-GG----R
SMSFNVSSG--SGR-TG------------------------GY-----------------
------------------------------------------------------GFCRGR
ATGFASSMFGSVALG-PS---YP----ATYV-P-GG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-VD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPIYEGHISSLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRVIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------DHQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEESR------------MSGEYTNSVS-----------ISVISSSNS---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGLSGPGTYG-YRT-----------
-----------------SS-------VSGGYSV---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EVKTKLGSGN-----DFK-------DAP---GKT-------S--VLSSPT
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGAA-------------------------------NRGFSGCS--
AVLS-S--------S---SSSY----RAGG------------------------------
-----------------------------------KGL-GAGFSSRSLYSLR-GA----R
SISFNVAGS--SGR-TG------------------------GY-----------------
------------------------------------------------------GYGRNR
ASGFAGSMFGSGALG-PS---NP----PLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-CFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPVYEAHINSLQKQ----LDTLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EHQELMSDK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTP---G-------
---------------------------------------------AVGAGAN--------
-----------------------------------FGFSSTGTYG-YRP-----------
-----------------SS-------VGGGYSL---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-ETKGRLGSAS-----ELK-------DAS---GKT-------L--ALGSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTYKSGVA------------------------------TKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGF-SGGFGSRSLYSLG-GT----R
SISLNMASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKR--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-VAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------LEGDVEGNSG-----------EKGLWVAP------------
----------------------------------------------CWAGDI--------
-----------------------------------W------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MNHRFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQAVGSVCLARGRCGGGGY-----------GGGFSSRSLYNLG-GS----K
SIFGSLVGRSASG--FCPGGGA--------------------GGFG------------GG
RS---------------FGG-GGFG-------------GGGYGGGRYG-----GGFGGSG
--FG-ASNFGFGGFG------------PAY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPLFESYISQLQRQ----VDFLNSER
-----------SRQNL-----EIRSMQDVVEDYKS--KYEDEINKRTNAE--NDF-VVMK
KDVDA----AFM-GKSDLQSKVDTLY---GEVNFLKYLFDTELS-QM-QTNISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYELITQKSKDE
AEALYQS---------K----YQEL-QV-TAGKHGD-DLKNSRM--------------EI
AELNRSIQRLQAE--I---------AAVKKQ-----------------IEQMHG----SI
ADAEERGERALQDAKQKLQDM---------------DDALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEET------------------------------------VH----------------
-------SSQ----------------------------VTVGGGGYGGGG----------
------------------------------------------------------YGGSRG
------------------------------------------------------------
---------------GGSGSYGGGAGSR--GSGGGGGG----------------------
------GS----YGSS-SRS--------------SSKYSS-------------GSGGGGG
G----RSGGSSRT-------QIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------LSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RLALSS-----AGR-SG------------------------GFTLGHG------------
------------------------------------------------------GASGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--SKRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKVLFEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILAEVR-AQYEEIAVKSKAE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKHTK--------------SEI
TEINRLIQRIHSE--I---------GNMKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MAGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGAS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPP---AKT-------S--GSSGAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
---------------------------------------------------GGFSSSS--
ASGGGR----SQAHT---SFSSVTVSQSSGSS----------------------------
-------------------------------EGARCGPRIGGFGSRSLHNLG-GS----K
SI---SGS------------------------VAGGAS------SGR-------------
-----------GPGG-FGLGG-G----A-------------------------------Y
---MGLGAGRQ------T---FR----PACP-P-GG-I-QQ-VI----------VN-Q-S
L--LTP-LN-VE-ID-PE-IQ-RVR-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-AL-LQEQGQ---NSGVTRKNLEPLFENYIRNLQR----NLDSLLSER
-----------ERLDS-----ELRNVRDVVEDFKN--XXXXXXXXXXXXX--XXX-XXXX
XXXXXXXXXXXX-XXXXX-X-----X---XXXXXXXXXXXXXMX-XX-XXXXXXXXXXXX
XXXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXXXXXXX
XXXXXXX-------------XYEEL-QV-TAGKHGD-NLRDTKN--------------EI
SELTRTVQRLQGE--M---------DAAKKQ-----------------CQQLQT----AI
VEAERCGDLALKDAQKKLGDL---------------DTALHHAKEDLARL-------LR-
------DYQALMNIK-------------------------------L-ALDVEIATYHKL
LESEES------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQSSCRSRGRG--GG-----------------------GGGYRGFSSGS--
AVVLSG------SRRSGTSFSC--LSRHGGGG----------------------------
---------------------------------------GGGFGSRSLVGLG-GG----R
SISMSVAGGGGGF--------GSGSGFGG-----------G-SGFSGGRGFGGGSGFGGG
SGFGGGSFGGGG----LGG--GRFGGGGGF-----------------------------G
------GLGGPGGFG------------PSGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMDV---ST--STANLDPLFQAYIGQLKKH----VDSLSAKR
-----------TSQES-----ELNNMQNLVEEFKK--KYEDEINKRTCSE--NDF-VTLK
KDVDN----AYM-TKVELQAKVDCAN---QELEFLKVLFSAELS-QI-QQTITDTSVIL-
-SMD-------------------NNRNLDL--------NSIISDI-QSQYESIAERSKTE
AENLYHS---------K----YEEL-QV-TAMKHGD-SLKDIKM--------------EI
SDLNRMIQRLQGE--I---------AHVKKQ-----------------CKSVQD----SI
TDAEQKGEHAIKDARNKLTEL---------------EEALQQSREDLACL-------LR-
------DYQELMNVK-------------------------------L-ALDMEIATYRTL
LEGEECR------------MSGDLS--SNVT---------MSVT----------------
-------SST----------------------------MSSSIASKAGFGSQ--GSGGRG
SSSG-GG--GG----------------------GGYSFG-SSSYGSGGRGS-------S-
--------------------SRGG--GG-RGG----------------------------
---SGSGGGYG----SG--GGSGGRQGS----RG--------------------------
------------------GSVSG-GGYGSG-G---GGYSSGGGSRG------GS--GGGY
G----SGGGSGGG--GCS---------SEK------GGSGEG------------------
--------------C------------------------------------------GSS
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQITCKSRGRG-G-------------------------GGGFRGFSSGS--
AVVSG-------SRRSTSGFSC--LSRHGGGGGS--------------------------
------------------------G--------GFGGGGSGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GSYGGFGG-----------RGG---------------GG
SSFGGGGFGGGN----FGG--GRFGGGGGFGGF-GG------------P----GGFGGPG
------GFGGPGGFG------------PGGYPG-RG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---ST--HTPNLDPIFQAYIDSLKKH----LDGLSAQR
-----------TSQDS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----TYM-TKVELQARVDALN---QELEFLKVLFNTELS-QI-QQSVTDTNVIL-
-SMD-------------------NNRSLDL--------DGIINEV-RTQYEEIAERSKEE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLREIKT--------------EI
SELNRMIQRLQGE--I---------AHVKKQ-----------------CKSVQD----AI
ADAEQRGEHALKDARNKLTDM---------------EEALQQAREDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEEYR------------MSEDLS--SNVT---------VCKLEGELWGRVALSSG---
--VACRGSST----------------------------ISSNVASKAGFGGS----GGRG
SGS---------------------------------------------------------
------------------------------------------------------------
------RGGYG----SG--GGSGGKYGSGGGSRG--------------------------
------------------GS----------------------------------------
G----SGGGYG------SGGGSRGG-SGSG------GGYSSGGGSG------------AG
GGSSSAKGSGSGE----------------------------------------------G
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQVNHY-------------------------------PGGGCLGFSGCS--
AVFSRA---------SSSSASF--------------------------------------
---------------------------------RAGIKGSVIVDSRSLFSLG-TS----R
RISTGNLNGRGGG-------------------------------HAPG----------HR
TGVG------------------------------------------------GGRVGSF-
----VGTVFGSAG----------------LGPP-GG-I-PQ-VT----------VN-K-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-MA-LN-KT-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-QW-NL-LQQQEL---NT--HRKNLEPIFEDYIGNLRKE----LGTRSGDR
-----------VRLDS-----EWRTVWDLVEDYRK--RYEVELNRCTAAE--NEF-VLLK
KDIDV----ACM-HKVELQAKVDSLT---DEIRFFKSLHKGPSS-RR--WPSSSPTLVL-
-SMD-------------------NSRDLDL--------DGIIAKV-KAHYEDMALRSKAE
AETTYQG---------K----IQEL-QV-TVSRHGD-DLKLTKA--------------EI
VELNRLVQRIRSE--I---------GSVKKQ-----------------CCNLET----AI
ADAEEQGNDALKDARAKQDGL---------------EAALQQ--DELARL-------LP-
------EYQELMSLK-------------------------------L-ALDVEMAAYRKL
LEGEESK------------MSGDYP--NSVS---------ISFVSSAGA-----------
------------------------------------------GAGRAGFGVGF---GASN
SLSS------------KAVPMDVKIKG---SCGSELKDPLAKISGS--------------
-----------------SCAAQRASR----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVDSLASH----CAAG------------------------------
-----------------------------------RGA-GAGFCSRSLYSLG-GN----R
HISFNVAGG--GVR-DG------------------------GYGFRPG------------
-----------------------------------------------------SGYGAGR
ASGFAGSMFGSVGLG-PA---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-GL-LQQLDL---SN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSTRDLVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QAHTSETSVIL-
-SMD-------------------NSRDLDL--------DSILTEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKRQTFSASN---EPAPCPLRCTSLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISIISS--------------
------------------------------------------------------------
----------------------------------------SSSSSYHHP-----------
-----------------GS-------AGADLRA---------------------------
----SAVA-------------------------------------------GSSGSTR--
--------SGQTKTKGARGG-----DLK-------DSQ---GKS------TP--ASTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSTRS--
---------------------------SSGF-GGG-------------------------
---------SRAVASLGQARGRCGGGGY-----GGY---GSGFGSRSLYNLG-GS----K
SISMNLLGRSSSG--FCQGRGV-------------------GGGFG------------GG
RGFGGGGFGGGG----FGSG-GLGGAG--------GFGGGGFGSGRFGG---GGGFGGAG
--FG-ASNMGFGGFG------------PAY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LQ-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KI-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---SM--RTSSLEPLLESYISELRRQ----VDTLNAEQ
-----------MRQNS-----EIRSMQDVVEDYKN--KYEEEINKRTNSE--NDF-VVLK
KDVDA----AYM-GKADLQSKVDTLY---GEINFLKFFYETELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVEYEMIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNTKM--------------EI
SELNRTIQRLQAE--I---------GNVKKQ-----------------IEQMHS----AI
GEAEDRGERALQDAKQKLQGM---------------DEALQQSKEDLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LECEESR------------MSGQLQDHV--S---------ISVH----------------
-------STQ----------------------------TTYSGSSS----S-----GGGG
----------------------------------------------------GSYGGGAS
R-------------G---------------------------------------------
--------------GGGG------GG----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFSSRS----------------------------RRAYSTRS--
---------------------------SSGF-GGG-------------------------
---------SRVVRSVGQAQGRHVSG-G-----GGY---GGGFGSRSLYNLG-GS----K
SIFGSLVSRSASG--FCQGRGG-------------------GGGFG------------GG
RGFGGGGLGGGR----FGGG-G--------------------------G---LGSFGGAG
--FG-ASNFGLGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LV-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KI-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPILEAYISELRRQ----VDLLNTEQ
-----------MHQNT-----EIRNMQDVVEDYKR--KYEEEINKRTNSE--NDF-VVMK
KDVDA----AFM-DKTDLQSKVDTLF---GEINFLKYLFDTELS-QM-QTHISDTNVVL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYEMIAQKSKDE
AEALYQT---------K----YQEL-QV-TAGRHGD-DLKNTKM--------------EI
SELNRTIQRLQAE--I---------GNVKKQ-----------------IEQMHS----SI
SDAEERGERALQDAKQKLQDM---------------DDALQQSKEDLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSHV--S---------ISVH----------------
-------SSQ----------------------------VTVGGGGGGSGGY-----GGGS
----------------------------------------------------GGYGGGSG
G-------------H---------------------------------------------
--------------GGGG------GGYSSSSSRGGGGYG-------------------GG
GSR---GGGGS-YGGSSSKS-----------------------------------GGRHG
V----RGGGSSRA-------QIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSWQVN-INSHG------------------------------NKGNFSVHS--
AVVP-RK-------AVGSVASY----HTAG------------------------------
-----------------------------------QGA-RVGFSSQSLYSLG-GN----R
LISSNVADS--GVW-AR------------------------GRSFEHG------------
-----------------------------------------------------SGYGGSQ
ARGFAGSMFGGMTLG-PA---CL----SVCP-P-RG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKNLEPIYEGHISGLRKQ----LEMLSGDR
-----------VKLDS-----ELRSMRDVVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADV----AYT-AKVELQAKVDSLD---KDIKFLKCLYDVEIT-QL-QTHASDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEDIARKSKTE
AEALYQTK-------------IQEL-QL-AAGRHGD-DLKHTR--------------NEM
SELNRFIQRIRCD--I---------ISVRK-----------------QCSNLET----AI
SDAEERGDSALKDAQAKLDEL---------------EGALHQAKEELARM-------MQ-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGSERA------------L--------------------CSIISSS-------------
------------------------------------------------------------
------------------------------------------GYG-YHP-----------
-----------------SS-------VSPDLGV---------------------------
----SSAA-------------------------------------------INLGSSR--
--------SGQTKTQGAQAG-----DLR-------DSQ---DKS------AP--GSAPAR
KTTC--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSMS----------------------------RRVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SPAVGSVCYARGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISINLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RGFGV-----------GS-----TGAG--------GFGGG--------------GFGGAG
--FG-TSNFGLGGFG------------PYC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRRQ----VDLLSAEQ
-----------MRQNA-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QV-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDAWQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSVNGGAGGGGSY-----GSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GRSGG-------------------GY
GSG---CG------GGGGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

----------MPSTYKEGCPASPHCKL-------------------QSPCGTWPSPLLHL
TSISTSSMNRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GI----R
NISLNMASG--SGK-S-------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKEELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------ESALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSTS-----DYK-------DTL---GKG-------S--SQSASS
KKASSSCLG---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
NISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVGLG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSW-GSTS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGFRSG------------------------------GGFSSGS--
AGVVSF------RRRMTSSSV----RHGG-GGGG--------------------------
---------RFSG-------GRCGGG-------GG-GAGGGGFGSRSLVNLG-GS----K
SISISVAGGG--RGGFGGGGFGGG--FG------------SGGGFGGG------------
-GFGGSGFGGGG----FGG-------G-GFG-------GGGFGGGGFGG----SGFG-GG
--GFGG-----GSFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHSLEPYFESYISSLRNR----VDQLKNDQ
-----------SRMDS-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYT-VKVELQAKVDSLD---KDIKFLKCLYDAEMA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAKV-RAQYEEIALKSKAE
AEALYQS---------K----IQEL-QL-AAGRHGD-DLKHTKN--------------EM
SELNRLIQRIRCE--I---------ANVKKQ-----------------CANLET----AI
ADAEQRGDSALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENP--LSVS---------ISVISSGGNSYYHP------
---------------------------------------STSGSADTG--P---------
-------------------------SGL--------V-------------GS-----SSS
TWAGQSRAK-------GAR-----------V-----------------------------
-------------------GDLKDARGKSAPSRKATR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHRFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQAVGSV--SRGRCGGGGY-----------GGGFSSRSLYSLG-GS----K
SIFGSLVGRSASG--FCLGGGA--------------------GGFG------------GG
RS---------------FGG-GGFGGG--------GFGS----GGRFG-----GGFGGAG
--FG-ASNFGLGGFG------------PSY-PS-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFESYISQLQRQ----VDILTSER
-----------SRQNL-----EIRSMQDVVEDYKS--KYEDEINKRTNAE--NDF-VVMK
KDVDA----AFM-GKSDLQSKVDTLY---GEVNFLKYLFDTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
AELNRNIQRLQAE--I---------ASVKKQ-----------------IEQMHG----SI
SDAEERGERALQDAKQKLQDM---------------DEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------IWTE----------------
-------AGW----------------------------AG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------R-----------------------------
-------GGLC-FLLS-YK------------------------------------E---H
-----QSEQGLLF-------LIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSAGS--
---------------------------SAGS-GGG-------------------------
---------SQAVGSVCLVGGRCGGGG--------YGSPARGFGSRSLFNLG-GS----R
SICFSLVGRNASG--FRQGGGA-------------------GGGFG------------GG
RCFGGGSF-----------------------------GGGGFGGAGYG----GGGLGGAV
--FG-GSNFRLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXX----XXXXXXXX
-----------XXXXX-----XXXXXXXXXXXXXX--XYEEEVNRRNNSE--NDF-VVLK
KDVDA----AYL-NKEDLQSKLNVLL---QEVDFQNCVIQMEPS-HM-YTNVTNTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RTEYELITQKSKAE
AEALYQT---------K----YQEL-QI-SAGRHGD-ELKTSKM--------------EI
SELNLTIQRLQSE--I---------SNIKKQ-----------------IDQMHM----AI
SDAEERGDRALQDAQQKLQDI---------------EAALQQSKEEMTRL-------LR-
------DYQALLGVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGELQSHV--S---------VSVH----------------
-------SSQ----------------------------VSVSGGGRGSGGY-----SGIY
-------------------------------------------------------SGGSS
------------------------------------------------------------
------------------GGYSGGGGSRGGAAR-GGSGG-------------------GY
GS----GSGGS-YGGSSRG---------------------------------------SG
R----SGGGSSHV-------QIIQT-STN-------------------------------
---------------------------------------------------------TTH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKRGFSGCS--
AVLS-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-GGGFGSRSLYSLG-GN----R
TISLNMASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GLGRGR
VSGFAGSMFGSVALG-PI---GP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPILEGYITNLQKQ----LEALSGDR
-----------VRLDS-----ELRNVRDLVEDHKK--KYEDEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFRCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-NQYEEIALKSKTE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDAGAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGESRSR-GGAS-----DYK-------DAL---GKG-------S--NPVTPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTYKSGTT------------------------------AKGGFSGCS--
AVLT-GA-------SSS---SY----RAGA------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GS----R
GISFNVASS--SGR----------------------------------------------
-----------A-------G--------------------------------GFGFGRSR
ASGFAGSMFGSVNLG-PS---CP----TVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CKNNLEPILEGFISSLRKQ----LEGLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEEEINKRTTAE--NDF-VVLK
KDVDA----AYM-SKVELQAKVDALD---REIKFFKCLYEGXXX-XX-XXXXXXXXXXX-
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------XXXXXXXX-XXFQ---------
-----------------------EL-QL-AAGRHGD-DLKHTK--------------NEI
SDLTRLIQRLRSE--I---------ESVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EEALQ-AKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSAA---G-------
---------------------------------------------TTGAGAG--------
-----------------------------------FGFSGASTYG-YRS-----------
-----------------SS-------VGGGYSM---------------------------
----LSGGCVT-----------------------------------G----SGNCSP---
--------RGEAKTRLGSAS-----EFK-------DAQ---GKA-------P--ALSSPA
KKNTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHRFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQAVGSV--SRGRCGGGGY-----------GGGFSSRSLYSLG-GS----K
SIFGSLVGRSASG--FCLGGGA--------------------GGFG------------GG
RS---------------FGG-GGFGGG--------GFGS----GGRFG-----GGFGGAG
--FG-ASNFGLGGFG------------PSY-PS-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFESYISQLQRQ----VDILTSER
-----------SRQNL-----EIRSMQDVVEDYKS--KYEDEINKRTNAE--NDF-VVMK
KDVDA----AFM-GKSDLQSKVDTLY---GEVNFLKYLFDTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
AELNRNIQRLQAE--I---------ASVKKQ-----------------IEQMHG----SI
SDAEERGERALQDAKQKLQDM---------------DEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------ISVH----------------
-------SSQ----------------------------VTVGSGSYGGGSG-----GGSG
-------------------------------------------GYSGG------YGTSSR
------------------------------------------------------------
---------------GSG---------G--G-----------------------------
-------GGGS-YGSS-SKS--------------SSKY----------------GG---S
G----RNSGSSRT-------QIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSNRS--
---------------------------SSGF-GGR-------------------------
---------NRAVGSVSQAWGRYGA--------GGCGGHGRGFGSRSLFNLG-GS----K
SISMALGGRRASG--FQQGRGA-------------------GGGFG------------GG
RSFGGGGL-----------------------------GGGAFAGAGFR----GGGLGGAG
--FG-ASNFGPGGFG------------PSY-PP-GG-I-RE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-IQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--QNSNLESFFESYISGLQKK----VDFLNNEQ
-----------MRKNS-----EIRSMQDTVEDYKS--KYEEEINKRTSAE--NDF-VVLK
KDVDA----AYV-SKTDLESKVDTLL---GEVNFLKYLFQMELS-QM-QTHISDTNVIL-
-SMD-------------------NNRTLDL--------DSIIEAV-QAEYELIVQRSKDE
AEMLYQT---------K----YQEL-QI-SAGRQGD-DLKNTKM--------------EI
AELNRNIQRLQAE--I---------GSVKKQ-----------------IEQMHS----AI
SDAEERGQQALEDAKQKLQDM---------------DEALQQSKESLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LECEESR------------MSGEMQNQV--S---------ISVE----------------
-------SNQ----------------------------VTLSGGAAG--GS-----G--G
-------------------------------------------YGGGGGYSGGG---GNF
------------------------------------------------------------
-------------------------------------GG-------------------GG
SR---GGSGGG-YRRRVV-E----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFS--S----------------------------------RSAFSSRS--
RRIY---------SL---GSSARCGGGS--------------------------------
-------------PAVCQARGRCGG-----G---GYGSHVREFGSRSLFNLG-GS----K
SISVSLVERSSS--GFRQGGGA-----------------------GGG--------FGG-
----GRAFGV---GN-FG--------GSGYG------------G---------GSFGGIG
---FGGSNFGLGGFG--S----------SCP-L-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-AQI-MV-LN-NK-FA-SFI-DK-VRL-LE---------------------Q-
QN-QV-LQM-KW-EL-LQQINT---ST--RTNNLEPVLENYIGELRRQ----LEFLDAEQ
-----------MRQNM-----EILSAQDAVEDYKN--KYEEEINQRTNNE--NDF-VILK
KDVDA----AYI-SKVDLQSKADVLS---GEVNFLKYLFEMELS-QM-QTHISDTNVIV-
-SMD-------------------NNRSLDL--------DSIIDAV-QAQYEMIARKSKEE
AEALYQS-------------KYQEL-QM-MAGRHGD-NLKNNKM--------------EI
AELNRTIQRLQAE--I---------SNTKKQ-----------------LDQMHT----AI
SDAEEXXXXXXXXXXXXXXXX---------------XXXXXXXXXX-----XX-XX-XX-
X---XX-XX-XX-XX--------------XX-XX-----------XX-X---XXXXXXXX
XXXXXXX------------XXXX------------------------X--XXXXXXXX--
------------------------------------------------------------
-----------------------------------XXXXM-TISGAQGSGGGG-----SG
GYGGS-G-----------G------S-SWGYGGGSSFG----------------------
---GGGG--Y-------GGGSRGG----------------SGG-GYGS------------
--------------H------------------NSGNY---GG-----------SS----
-------------------------------------K---------GSSG---------
---------------------------------------------------------SSR
LQIIQTST-NTSH-RRIVE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSNRS--
---------------------------FSGS-GGR-------------------------
---------SRAAGSVSQAQGRCDS--------GEYGGHGRGFGSRSLFNLG-GS----K
SISMGLVGRSASG--FHQGRGA-------------------GGGFG------------GG
RSFGGGGF-----------------------------PGGRFGGAGLG----GGGLGGAG
--FG-ASNFGPGGFG------------PSF-S--GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-SQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LQT-KW-EL-LQQVDI---ST--RTSNLETLFESYISGLWKN----VDFLNNEQ
-----------MRKSS-----EIRSMQDVVEDYKN--KYEEEINKRTSSE--NEF-VVLK
KDVDA----AYV-SKTDLESKVDTLL---GEVNFLKYLFQMELS-QM-QTHISDTNVIL-
-SMD-------------------NNRTLDL--------DSIIEAV-QAEYELIVQRSKDE
AELLYQT---------K----YQEL-QI-SAGRHGN-DLKNTKM--------------EI
AELNRNIQRMQAE--I---------GNVKKQ-----------------IEQMHS----AI
SDAEERGQRALEYAKQKLQDM---------------DEALQQSKENLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LECEESR------------MSGEMQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTLSGGAGG--GS-----G--R
-------------------------------------------HGGG-GYSGGGYGGGGY
G-------------G---------------------------------------------
----------------------------------GGGGG-------------------GG
SA---SGSGGS-YRASSR-S--------------SSK-----------------YG----
-----GGGGSSRT-------QIIQT-STS-------------------------------
---------------------------------------------------------SSR
RRVVEQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFR------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
STSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGGSKD--------------------------
------------------GS--G-FG---G-----G-YSSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRQSVCRSFGG---G--------------------------SRRGYSSCS--
AIGGGFGGGGGRSRSSYSSFS---MSR---------------------------------
------------------------G--------YGGGGRCGGFGSRSLHNIG-SS----G
RIAMGGCYSGGGYGGRMGGFGGGY-G--------------GLGSYGGGMGGGG--M--GG
F----GG-GMGG----GGGM-GGFGGGMGGY-------GGGMG---GGG---MGGYGGPG
---FGFGGP---GRG------------GP------G-I-QP-VQ----------VD-P-T
L--LQP-VH-VE-ID-PQ-IQ-QVK-NQ-E------------------------------
------K-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LST-KW-EL-LQQQGP---SG--PRKNLDVIFENYIQNLRRQ----LDSILAQR
-----------GQLES-----ELQNMQQYVEDYKN--KYEEEINRRTTAE--NEF-VVLK
KDVDT----AYM-TKVELEAKVGALT---DQINFLRAIYEEELS-QM-QTISRDLSVVV-
-SMD-------------------NNRHLDM--------DSIIEEV-RRQYEQIAQSSRAE
AEAWYQS---------Q----YEQL-QS-TAGMHGD-SLRNTKI--------------EI
QELTRNIQRLRAE--I---------ENVKKQ-----------------NQQLQA----AI
AEAEERGEMALKDARVKLEEL---------------EAALSKDKEELARL-------LK-
------EYQELLNIK-------------------------------I-ALDVEIAMYRKL
LEGEENR------------LCNDGM--SNVN---------VSVV----------------
-------GRT----------------------------TISGGRGGMG-GGFGGSGMGGG
F-------------------------------------------------GG------S-
--GMGGGF-GG-------------------------------------------------
----------SGMGGGFGGSGMGG----------GMGS-------GGGFGGGSSGGSCGM
GGGM--------Y----------SGGFSSG----SGRM--------------CGSGGGNF
S----SGGGSSSI--RR----CVTT-TSVKSSGVRF------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------MASTSTTIRSH--SS----------------------------SRRGFSANS--
ARLPGV------SRSGFSSVS---VSRSRGSG-G--------------------------
------------------------L--------GGACG-GAGFGSRSLYGLG-GS----K
RISI--GGGS-CAISG--GYGSRAG-----------------GSYGFGG-------AGS-
-----------G----FGFG-G-------------------GAGIGFGL-------GGGA
--GLAGGFGG--PGF------------PVC-PP-GG-I-QE-VT----------VN-Q-S
L--LTP-LN-LQ-ID-PA-IQ-RVR-AE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-D-------------------------------
------------------------------------------------------------
------------------------------------------------------------
KDVDA----AYM-NKVELQAKADTLT---DEINFLRALYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CASLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------VSVV----------------
-------QST----------------------------VSSGYGGAS--GV---------
---G-----------------------------S--------------------------
------------------G--------------------------------------LGL
G------------------GGSSYSYGSG--LGV----GG-GF---------SSSSGR--
---------------------------AT---------------------------GGGL
S----SVGGGSST--I----KYTTT-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKN----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCKSRRGGG----GGA---------------------GFRGFSSGS--
AVVSGG------SRRSTSGFSC--LSRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISTSVAGCGGG--FGGRSSFGGS------------------GGFGGGSGFGGGRGFGGS
VGFGGG----SG----FGGG-SGFGGGSGFGG-GSGFGGGGFGGGGFGG----GRFGGG-
----SG-FG-----G------------PGGFPG-GG-I-HE-VS----------AN-Q-S
L--LQP-LD-IK-LD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LHT-KW-EL-LQQLDV---GT--QTTNLDPIFQAYISMLKKQ----VDRLIAER
-----------TSQDS-----ELSNMQDLVEEFKK--KYEDEINKRTSAE--NEF-VTIK
KDVDS----SYM-DKTELQAKTDILM---QEADFLRTLYDAELS-QL-QQNVTDTNVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-QSQYEIIAHKSKTE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------AHVKKQ-----------------CKGVQD----SI
ADAEQRGEHALKDARTKLTDL---------------EEAMQQARENLTRL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------GGQNSWIDIISP---------TAVT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---------------------------------------TYGSGGRNSG------SR
----GGSG-GGGFSSGGGS--RGG--SGGG------------------------------
------------------------------GFRGGFSSGGGGFSSGGGSRGGSGG--GGF
SSGGGSRGGSGG---G-----------------------AGGGSRGG-----SGSGG---
------------------------------------GGYSSGGGSRGGSS------SGGA
VSSSERGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCYTSSSLL------------------------------GRRGFSSAS--
AVCG------------------------LGRAGS--------------------------
-----------SSASVCQ--------------PAARRCGLGGFSSRSVCDLG-RG----Q
RISFGGSCRSAAY---GAGSVGRCGTAYG-------------------------------
----GGRFGVGTVVG-FGNCG-GYGG---LGG---------YRG---------LGDGISI
G--L-----------------------GGGR-S-EG-I-RG-VS----------IH-P-E
L--LKP-LC-VG-VD-PE-EC-QVR-TH-E------------------------------
------K-EQI-KN-LN-NQ-FA-CFI-DK-VRL-LE---------------------Q-
QN-KV-LTT-KW-EL-LQQYVL---PA--SRRNLEPVFENFICNLRKQ----LECVLGER
-----------ERLEN-----EERCLRDLVQEYKC--KYEDEINKRTAAE--NEF-VVLK
KDVDC----LYL-TKEELEVRVGLLR---QQLEFLKCIYAEERA-QM-DCQLCDTSVIV-
-QMD-------------------NSRDLDM--------EGIIKSV-ECCYEEIAQKSKAE
VEAFYQT-------------RLEEL-HS-SRGKFCD-DLRNNQS--------------EI
AELNRMIQKLQCE--S---------DNVKKQ-----------------IAALQT----AI
CDAEQRGDCALKDARQKLVDL---------------QTALQQAKDKMACL-------LR-
------DYQELLNVK-------------------------------L-ALDIEIATYRTL
LEGEESR------------ICTGNP---------------VSVAVVSG--GGTVGECRSL
SGIGGKCS-VK------TG---ASSG---LGGVVS----SFG-VSGAGFSA---------
RSVD----------CVPRVG--------GGFGARSAASCVGREVLSGAD-----------
-----------------GL------QCAAG--VGNLVC----------------------
---AGVEQCSP-------------------------------------------------
------------------------------------------------------------
-----------------------------GTVIIPGPGVCG-----GGNRY---------
---------------------------------------------------------STA
VRVVRTSR----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGV-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKMDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSGK
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGSFGSRSLYSLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------F-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--KEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSCCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GTAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADE----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SGIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLEKQ-----------------NASLQA----AI
ADAEQHGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGGL-GSVCGLGGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--GVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSIFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------NSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKKQ-----------------CASLET----AI
ADAEQRGDSALKDARAKLEEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISN--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DFQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQAPTVRSVL------------------------------GRRGFSSAS--
EICG------------------------RSYA----------------------------
--------------AACQ--------------P--ARCAAGAYSSRSVCNLG-GS----R
RISYVNG---------------VCGNGC--------------------------------
----FGDFGFGGVVG-YGNAG-GRVS---LCG-----------P---------RGYSIVR
G--Y-----------------------PDRK-G-EG-I-QG-IC----------ID-E-R
L--LKP-LC-VG-VD-PL-EH-EIR-CQ-E------------------------------
------K-EQI-KT-LN-TQ-FA-CFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-GL-LQQYVL---PK--KGKNLELYFENYICDLRKR----LDCLLCEK
-----------QKLGN-----EECATSQLVEEFKC--KYEEEINRRTTVE--NEF-VALK
KDADC----IFL-NKEELEVKVDLLR---RQLELLKCVFEEERA-QV-DRQLCDTSVIV-
-KMD-------------------NNRDLDM--------ESIIKNV-ECWYQEIAQKSKEE
VDAFYQT-------------R--EL-QD-KRGKYCD-DLQSNKC--------------EI
SELTRMIQKLQCE--L---------ENV---------------------SCLQT----SI
CDVEQRGDCALKDAREKHVEL---------------QNALQKAKDELACM-------LR-
------DYQELLNVK-------------------------------L-ALDIEIATYKTL
LEGEESR-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSMHS--
AVAP-RK-------AVGSLASH----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
RISFGVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGAGR
ASGFAGSMFGSVGLG-PA---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPIFEGYVSNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NSRDLDL--------DSILAEAR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKRQTFSVSN---KTAPCPLRCASLET----TI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISIISS--------------
------------------------------------------------------------
----------------------------------------S-SYSYHHP-----------
-----------------SS-------AGADLRT---------------------------
----SAVA-------------------------------------------GSSGSTR--
--------SGQTKTKGVRGG-----DLK-------DSQ---GKS------TP--ASTPAR
-KTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSLRS----------------------------RRVCSSAC--
---------------------------PAGA-GGG-------------------------
---------SRAVGSVRQARGRYGGGGG-----GGYGGYGRGFGSRSLYNLG-GS----K
SISFNLVERSASG--FRQGGGA-------------------GGGFG------------GG
RGFGGGGFGGGS-----------FGGS--------GFGG--------------GSFGGAR
--FG-VSNFGLGSFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LN-LE-VD-PE-IQ-RVK-SQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQVNT---ST--QTSNLEPILENFINLLQKQ----VDFLNGER
-----------MRQDT-----EARNMQDVVEDYKT--RYEEEINRRTSSE--NDF-VVLK
KDVDA----AYM-NKTELQARVDTLY---GELDFLKYLFDKELS-QM-XXXXXXXXXXX-
-XXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXXXXXXX
XXXXXXX---------X----YQEL-QI-TAGRHGE-DLRNSKM--------------EI
TELNRIIQRLQAE--I---------DNLKKQ-----------------RDQMDS----AI
SDAEERGERALQDAQQKLQGM---------------EEALQQSKEELARL-------LR-
------DYQALLVAK-------------------------------L-ALDVEIATYRTL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VTVSGGGGSGS-L-----GSGG
-------------------------------------------YYGGGGSSRGGS-----
------------------------------------------------------------
---------------GGGGSSRGGSGGGGGSSR-RGGGG-------------------G-
------------YGGSSGS-----------------------------------YGG--G
G----RSGGGSSV-------QIFQT-STT-------------------------------
---------------------------------------------------------FHK
RI-WGQ------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GI----R
NISFNVASS--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDGVEDYKR--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALLQAKEELARL-------LR-
------EYQELLSLK-------------------------------P-ALDMEIATYRKL
LEGEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGG-----------------
---------------------------GRGYTA---------------------------
----GSSSCVS-----------------------------------------GVCSVR--
--------GGDGRGR-DSSS-----DYR-------DTL---GKG-------S--SQSAPS
KKAGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------MSR---QFSSQSA-----------------------------------
----------------SARRKRL----XX-XXXXXXXXXXXXXXXXXXXXXX-XX----X
XXXXXXX-----------------------------------------------------
-----XXXXXXXXXXXXXXX-----------------------X---------XXXXX--
-------XXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXX--------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------------------
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXX
-----------XXXXX-----XXXXXXXXXXXXXX--XYEEEINRRNGAE--NDF-VVLK
KXXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXELS-QM-QTHTSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKI-------------E-I
TELNHSIQRLQAE--I---------ANIKNQ-----------------VNHIHS----AI
SDAEERGREALQDAQQKLQDL---------------EDALQQSKEEMARM-------LR-
------DFQELLGVK-------------------------------L-ALDIEIATYRKL
LEGEESR------------MSGDLQSQVSIS---------VHTSQVTH--SGSGGDR---
--------------------------------------------------G---------
GRAS----------GGPGGS--------GGAYGGGGSR-------GGSSGGGG-----EG
SYGKGSG----------S-------SEGSYVGS-S-------------------------
---R-SGGSS------SRLHIIQTSTNTSHKLIVE-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MA-P--YG-N-RS-ME----------MK-I-T
I--IVP-K----------------------------------------------------
------------------------------------------------------------
---QP-PKN-KW-AI-EVGGRG---KD--MRNWGNT-HTHTHTHTQKV----CGGVSGRK
TQFGPICFVESGDPRLILLYYLHLWLNYVLPCSNS--RYEDEINKRTAAE--NEF-VTLK
KDVDA----AYM-NKVELQAKVDALT---DEINFTRALYDAELS-QM-QTHVSDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQS---------K----YEEL-QL-TAGRHGD-DLRNTKQ--------------EI
SEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQS----AI
ADAEQRGEMALKDAKNKLAGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYR--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGVA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-SP----R
SISFNVASS--SGR-TV------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGALG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--CRRNLEPVYEAHISSLQKQ----LDSLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIT-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------ERALHQAKEELARM-------LR-
------EHQELMSMK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSAP---G-------
---------------------------------------------TVGAGTS--------
-----------------------------------FGSSSTGAYG-YRQ-----------
-----------------SS-------VAGGYGI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-DTKSRLGSAS-----EFK-------EVS---GKT-------S--ALGSPS
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MGFG-------------------------------
----GV--------G-YGSVGGGRVG---LCG-----------P---------RGYNIVR
G--Y-----------------------PERK-A-DG-I-QG-IC----------ID-E-R
L--LKP-LC-VG-VD-PL-EH-EIR-CQ-E------------------------------
------K-EQI-KT-LN-TQ-FA-CFI-DK-VRL-LE---------------------Q-
QN-KV-LTT-KW-EL-LQQYVL---PA--SRRNLEPVFENFICNLRKQ----LECVMGER
-----------ERLEN-----EERCLRDLVQEFKC--KYEDEINKRTAAE--NEF-VVLK
KDVDC----LYL-TKEELEVRVGLLR---QQLEFLKCIYAEERA-QL-DCQLCDTSVIV-
-QMD-------------------NSRDLDM--------EGIIKSV-ECCYEEIAQKSKAE
VEAFYQT-------------RLEEL-HS-SRGKFCD-DLRNNQS--------------EI
AELNRMIQKLQCE--S---------DNVKKQ-----------------ISALQT----AI
CDAEQRGDCALKDARQKLVDL---------------QTALQQAKDKMACL-------LR-
------DYQELLNVK-------------------------------L-ALDIEIATYRTL
LEGEESR------------ICTGNP---------------VSVAVVSG--GGTVGECRSL
SGLGGKCS-VK------SG---GAGA---GLGMVS----SFG-SAA--FSA---------
RSPP----------PPPPPP--------PPPPPPP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------PPPPPPPP-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDS---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------SNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GG----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGWNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDTMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYS------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGENRSR-GSAS-----DYK-------DTL---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQALVSVSQ--SRRYGGDY-----------GGGFSSRSLYSLG-GS----K
SIFGNLVGRSASG--FCQSRGP-------------------GGGFG------------GG
IGGGI------------GGG-RGFGGG--------GFGGGYGGGGRFG-----GGFG---
-----GAGFGFGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFEEFISQLQRQ----VDVLTTEQ
-----------LRQNT-----EIRNMQDVVEDYKN--KYEDEINKRTNAE--NDF-VVLK
KDVDA----AFM-GKSDLQSKVDTLY---GEINFLKYLFDTELS-QI-QTNVSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RAQYEIIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNIQRLRAE--I---------ANIKKQ-----------------VEGMHG----LI
SDAEERGERALQNAKQKLQEM---------------EEALQQSKEDLAKL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGALQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTIGGGGGGSGSY-----SGSS
-------------------------------------------RGGGG------------
------------------------------------------------------------
-----------------------GG-GT--GSRG--GG----------------------
------GGGSS-YVSS-SRS--------------ATKYGS--------------------
------GGGSSRT-------QILQT-STH-------------------------------
---------------------------------------------------------SSR
RHVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCK-SGA------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-TGSFGSRSLYSLG-GA----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
TELTRLIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LETECA-------------W---GR--SL-----------S-SITVTII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-G--S-----DYK-------DTL---TKG-------S--SLSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGSGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGG------GFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------ANRGFSGCS--
AVLS-GG-------S---SASY----RAGG------------------------------
-----------------------------------KGF-GGGFSSRSLYSLG-GA----R
NTSFNGPSS--SGR-AG------------------------GY-----------------
------------------------------------------------------GFCRNR
ASGFAGSMFGSVAMG-SS---SP----SMCL-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKSLEPIYEGHISSLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NDF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-TQYEDIALKSKAE
AETLYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELSRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------ENRLQQSKEELARM-------LR-
------EHQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGAGTS--------
-----------------------------------FGFNGTGTYG-YRS-----------
-----------------SS-------VGGGYSM---------------------------
----LSGGCVT-----------------------------------G----TGNCSSR--
--------G-EPKTRLGSAS-----EFK-------DAP---GKN-------L--VLGSPT
KKATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKQGAV------------------------------TRAGFSGCS--
AVLS-GG-------S---SSSY----RAGA------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GT----R
SVPFNVACG--PGR-AG------------------------GY-----------------
------------------------------------------------------GFGRGW
ASGFAGSMLGNVNLG-PS---SP----SMYP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKNLESIYEGHISSLRKQ----LETLSGDR
-----------VRMES-----ELRTMRDIVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQTKVDALE---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------NEI
SELTRFVQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELTSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVVSSSMA---G-------
---------------------------------------------TAGAGAS--------
-----------------------------------FGFGGTSTYG-YRP-----------
-----------------SS-------VTGAYGI---------------------------
----LAGGCVT-----------------------------------G----SGNCTPR--
--------G-EAKTRLGSAS-----EFK-------DVP---GKT-------S--ALSLST
KKTVR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADE----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQITIS----------------S--VGD-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGGL-GSICGLGGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRA-----------------------------GGGFRGFSSGS--
AIVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
------------------------G--------GGGGYGAGGFGSRSVIGLG-GS----K
SISSSVAGG-GGFGSGGGFGGRG--GGF--------------GGFGGGS------SFRGG
SGFGG-----------------------------GGFGGGGFGGGSFG----GGRFGGGG
--GPGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VN-VD-PE-IQ-KRK-SQ-E------------------------------
------R-EEI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---GS--RTTNLEPIFHAYINQLQKQ----VDALTSEK
-----------NAQDS-----ELNNVQDLMEDYKK--KYEDEINKRTSAE--NDF-VTLK
KDVDS----GYM-NKVELQTNVDTLT---QEVDFLRRLYEAEMS-QV-HETITETNVIL-
-SMD-------------------NNRNLDL--------QGIIADV-KSQYEDIAQKSKAE
AETLYHS---------K----YEEL-QI-TAGKHGD-SVRELKM--------------EI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKSVQE----AI
ADAEERGERAIKDAQNKLTDL---------------EEALQQARENLARL-------LR-
------DYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGELSD-NV-T---------VSVT----------------
-------SST----------------------------ISSNT---TSFGGQG----SGG
RGS---SHGGG----------------------GGYSSG-SSSYGSGGRRSG------SR
S-GGGGSS-FGS--SRGGS----S--SGGGYGS---------------------------
-----------GS-------GSGGGR-------GGSGS----------------------
--------------------------------------------------------GGGY
G----SGGGSK---------------GG----SSSGGGFSSRGGSRGGSS------SGGG
VSSLEKVGSASVEG---------F---------------------------------SSG
---------ATFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------MASC----QATG------------------------------
-----------------------------------YRV-GAGFSSRSLYSLG-GN----R
HISFDVAGG--SAR-AT------------------------ELRFGHG------------
-----------------------------------------------------SGYGGTR
TSGFASSMFGIVDTG-PT---CP----FMCL-P-GG-I-HH-VI----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LNT-KW-EL-LQQLNL---NS--CKGSLEPVYEAHISSLRKK----LEMLSGDR
-----------VRLDS-----ELRNMRDMVEDYKK--RYEVEITRRTAAE--NEF-VLLK
KDADA----AYM-VKVELQAKVDSLE---KDIKFLKCLYDAEID-QL-QTHVSDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEDIALKSKAE
AEALYQTK-------------IQEL-QL-AAGCQGD-NLKHTR--------------NEM
LELNRLIQRIRRD--I---------ANVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------EYQELMGLK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSY------------
------------------------------------------------------------
-----------------------------------------GSYG-YHP-----------
-----------------SS-------MSSDFGA---------------------------
----GNAT-------------------------------------------GSPSTTR--
--------NSQTKTRGARAT-----ELR-------NSQ---NKS------TA--VGSPAK
-KTT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSVCRSG----------------------------G-RGFSSGS--
AGLVNF------HHRSSSSSV----RRSGG-GGG--------------------------
---------RFSG-------GFCGSG-------GA----GGGFGSRSLVNLG-GS----K
SISISVARGG-GRSGFGGGF-------G---------------SGYGG------------
-SFGSGGYGGGG----FGG-------G-GFGSGG--FG----SGGGFG----GGGFG-GG
--GY-G-----GGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-D-------------------------------
------------------------------------------------------------
-------------------------------------KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQAKTDNLK---QEIEFLTALYEAELS-QM-QSHISETNVIL-
-SMD-------------------NNRTLNL--------DGIIAEV-KAQYEDIAQKSKAE
AEALYQS---------K----YEEL-QI-TAGKHGD-SVKNSKM--------------EI
SELNRVVQRLRSE--T---------DSVKKQ-----------------ISSLQQ----SI
SDAEQRGENALKDAQNKLNEL---------------EDAL--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSRG------------------------------DKGNFSVHS--
AVLP-RK-------AVGSLASY----HAAG------------------------------
-----------------------------------KGA-GAGFSSRSLYNFG-GN----R
RISLNVAGS--SSQ-AG------------------------GYSFGHG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-LA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CKKNLEPILEGYISNLRKQ----LETLSADR
-----------LRLDS-----ELRSMRDQVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-AKVELQAKVDSLD---KDIKFLKCLHDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-VHYEEIALKSKAE
AEGLYQTK-------------MQEL-QL-AASRHGD-DLKHTK--------------NEM
SELNRLIQRLRCE--I---------GNVKKQPFPVSK---KPVPCVLQCTNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMGLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISV-----------------
------------------------------------------------------------
--------------------------------------ISSSSYG-YYP-----------
-----------------SF-------AGADLVA---------------------------
----SGVA-------------------------------------------GSSSSTR--
--------SGQIKTKGARGG-----DLK-------DSQ---DKS------TL--ASAPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG--GG-----------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGGG--------------------------
-------------------------------------FGGGGFGSRSLVGLG-GT----K
SISISVARGGGSF--------GSSGGFGG-----------R-----GGSGFGGGSGFGGG
SGFGGGGFGGSG----FGG--GRFGGGGGF-----------------------------G
------GFGGPGGSR------------PGGYPG-GG-I-HE-VS----------VN-E-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GT--RTTNLDPIFQAYIEDLKRY----VDRLSAER
-----------TSQDS-----ELNNMQDLVEDFRK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYI-TKVELQAKVDVQN---QDLEFLKILFDAELS-QR-QQTITDTNVIL-
-SMD-------------------NNRNLDL--------NGIIDEV-RAQYEDIAQKSKTE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLREIKT--------------EI
SELNRVIQRLKGE--I---------AHVKKQ-----------------CKSVQD----AI
ADAEQRGEHAIKDAKNKLTEL---------------EEALQQSREDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------FSSNVASKAGFGGP--GYGGRG
SSSG-----GG----------------------GGYSSG-SGGYGSGGRGS-------S-
--------------------SRGG--GGG--G----------------------------
---SGSGGGYG----SG--SGSGGKYGSGGGSRG--------------------------
------------------GSSSG-GGYGSG-SGSGGGYGSG-------------------
-------------------RGSRGG-SSSG------GGYGSGGGSKGGSG------AVGG
DSGSVKGGSGSGEGF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFSSRSGYRRG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RSSG---------------G----FCSGGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGSG------------
-GGG---FG-------SGG-------G-GFGSGGGGFGS---GGGGFGG----GGFG-GG
--GFG---GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PQ-IQ-KIK-SQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---SS--RTHNLEPYFEAYINNLRNK----VDRLKNDQ
-----------SRMDS-----ELKQMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-GKVDLQAKVDNLQ---SDIDFFTTIYREELA-QM-QTQISETNVIL-
-SMD-------------------NNRSLNL--------DGIIAEV-KAQYEDIAQKSKAE
AESAYQT---------K----YEEL-QV-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----TI
SEAEQRGENALKDAQSKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEEI R------------MSGECP--PNVS---------VSVSTSHT------------
---------------------------------------SISGGGGGG--G---------
---------------R--------------------GGG-GGSYGSGGGSGGGSYGSGGG
SYGSGGGSGGGSYGSGGGS-----------YG----------------------------
-SGG-GGGGGSGGR-G------------SGGYGSSSGGGS--------SGGHRGG-SG--
------GGGSSGGSTGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFIST-SYSR------------------------------
------------------------------------------------------------
--------------------GSR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SPSY----RAGV------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GS----R
SISYNVTSG--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PA---CP----SVCP-P-GG-I-SQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPVYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIINEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QM-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARVKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TPGTGAG--------
-----------------------------------FGFSGAGTYG-YRP-----------
-----------------SS-------V--GYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DPS---GKT-------S--ALSSPT
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-SLHVNM-SRHFSSRSGYRC---------------------------GGGGGGFSSGS--
AGVVSY------QRRSTSS--S--VRRSGGGGGR--------------------------
------------------------F--------SGGVCGG--------------------
-------GAGGGFG--------VAGG-------------GGRGGFGGGYGGGY-----GG
GGFGGGGFGGGG----FGG--GGFGGGGI---------GGGFGGGGFGG----GGFGGGG
------VWGGGG-----------------------G-I----------------------
-----------------------QE-SQ-E------------------------------
------R-EQI-KS-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINT---ST--RTYSLEPFFEAYISNLRRN----VDQLKSDR
-----------SRLDS-----ELKNMQDLVEDYRS--KYEDEINKRTNAE--NEF-VGIK
KDVDA----AYI-TKVDLQAKFDNLL---QEIDFFKTLFQAELS-QM-QTHISDTNVIL-
-SMD-------------------NNRNLDL--------NSIIDEV-KNQYEEIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGQHGD-SLKNTKM--------------EI
SELNRVIQRLRSE--I---------DSVKKQ-----------------ISSLQQ----AI
SDAEQRGENAIKDAQNKLNEL---------------EDALQKAKEDMARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRTL
LEGEESR------------MSGECV--PNVS---------VSVSTSH-------------
----------------------------------------TSISGGGGRGGGGFSSGGGG
YSSGGGG--GG---------------GYGSGGGGGYGSGGGSSYGSRGGRAD------PP
RWGRAGLY-GRT---SSSCLSRHG--GGSGVFGGGGFGGGGFSSRSLINLGGSRSTSISV
SGGGGSFGSYGGFGGRG--SGFGGGLGVGGGSFGGGRFGG-----GGGFG--GFGGPGGF
GG----PAGFGGYGSGGRGSSSG-GGFSSG-SS---SYSSGGRRSGS-----RSGGGGSY
G----SG------------GGSRGG-SSFGGGYSSGGKHSSGGGARGGSS------SGGG
TYGSERGASGSSEGG--------S---------------------------------SSE
KSVVEGICTLESSFLK-----ESPCH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSASS--
---------------------------SAAS-GGG-------------------------
---------SRAVGSVCHAQGRCGG--------GGYGSHGRAFGSRSLYNLG-GS----K
SISINLVGRSASG--FRQGWGA-------------------G-GFG------------GG
RGFGV-----------GS-----IGAC--------G---------GFG----GGGFGRAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TR-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTNNLEPLLESYIGGLQRQ----VDFLNAEQ
-----------MRQNM-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLQSRVDTLT---GEVNFLKHLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SSIKKQ-----------------IEQMYS----LI
SDAEERGERALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSH---------------------------------
--------------------------------------V-------SICNY-----GPGG
-------------------------------------------YGGG--SG-GGYGGGSS
R-------------G---------------------------------------------
---------------GGG------RSYGGGGSR-GGSGG-------------------GY
GSG-------------GGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RHILG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
------M-SCQITCKSRRSG--G------------------------GGGFRGFSSGS--
AVVSGG------SRRSGTSFSC--LSRHGGGGG---------------------------
---------------------------------GL---GGGGFGSRSLVGLG-GT----K
SISISVARGGGSF--------GSGGGFGG-----------RGGGFGGGFGGGFGGGFGGG
SGFGSGGFGGGG----FGG--GRMGG---GGGF-G-------------------GFGGPG
------GFGG-----------------PGGYP--GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINV---ST--RSTNLDPIFQAYIGQLKKY----VDSLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--RYEDEINKRTAAE--NDF-VTLK
KDVDN----TYM-AKVELQSKVEVLS---QEIEFMKALFDAELS-QT-HQTITDTNVVL-
-SMD-------------------NNRNLDL--------QSIIAEV-QSQYEEIAFKSKAE
AEALYQS---------K----YEEL-QI-TAGKHGD-SMKEIKM--------------EI
NELNRMIQRLKGE--I---------EHVKKQ-----------------CKNVQD----AI
ADAEQRGEHATKDAKNKLLDL---------------EEALQQAREELTRL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------VSSNVAAKAGYGG--AGSGGRG
YGSG--G--GG----------------------GGYSSG-SG------------------
----------------------RG--GGGGGYGSGSGG----------------------
--GYGSGGGYGSGGGSR--GGSGGGYGSGGGSRG--------------------------
------------------GS--G-GGYSSG-----GGYSSGGGSRG------GS--GGGY
G----SGGGYG------SGGGSRG---GSG------GGYGSGGGSK------------KG
GGSSQKAG--SGEGY------------------------------------------GSN
---------VSFSFT---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGLG
------GFG------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
STSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRGG--G-GGG-----------------------------
---SVSGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGD-SSSG------GRYSSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSN
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG--GT-----------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGGG--------------------------
-------------------------------------YGGGGFGSRSLVGLG-GT----K
SISISVARGGGS-------------GF-------------G-----GGGGFGGGSGFGGG
SGFGGGGFGGGR----FGGV-GGFGGGGGF-----------------------------G
------GFGGPGGSG------------PGGYPG-GG-I-HE-VS----------VN-E-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GT--RTTNLDPIFQAYIEELKRY----VDRLRAER
-----------TSQDS-----ELSNMQDLVEDFRK--KYEDEINKRTAAE--NDF-VTLK
KDVDS----AYI-TKVELQAKVDVQN---QDLEFLKVLFDAELS-QR-QQTITDTNVIL-
-SMD-------------------NNRNLDL--------NGIIDEV-RAQYEDIAHKSKTE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLREIKT--------------EI
SELNRVIQRLKGE--I---------GHVKKQ-----------------CKGVQD----AI
ADAEQRGEHAIRDAQNKLTEL---------------EEALQQAREDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--NSVT---------MSVT----------------
-------SST----------------------------VSSNVASKAGFGGP--GYGGRG
SGSG-----GG----------------------GGYSSG-SGSYGSGGRGS-------S-
--------------------SRGG--GGGGGG----------------------------
---SGSGGGYG----SG--GGSGGKYGSGGGSRG--------------------------
------------------GASSG-GGYGSG-GGSGGKYGSGGGSRG------GASSGGGY
G----SGGGSGGK--HGSGGGSRGG-SSSG------GGYGSGGGSKGGSG------SGGG
GSGSVKGGSGSVEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MNRQFTCKPGA-------------------------------ANRGFSGCS--
AVLS-S-----------SSSSY----RAGG------------------------------
-----------------------------------KGL-GAGFSSRSLYSLR-GA----R
SISFNVAGS--SGR----------------------------------------------
-----------T-------G--------------------------------GYGYGRNR
ASGFAGSMFGSGALG-PS---NP----PLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-CFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPVYEAHINSLQKQ----LDTLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYE---------
-----------------------DI-AL-KSKAEAE-MVYQTKVGVLA-------EREAH
TPSEAWETIGKRG--M---------PPPAP-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EHQELMSDK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTP---G-------
---------------------------------------------AVGAGAN--------
-----------------------------------FGFSSTGTYG-YRP-----------
-----------------SS-------VGGGYSL---------------------------
----LSGGCVT-----------------------------------G----SGNCSP---
--------RGETKGRLGSAS-----ELK-------DAS---GKT-------L--ALGSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------IK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NR-S
L--LEP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPTYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKIELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIHSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTCK-SGA------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYSLG-GA----R
SITLNMATS--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRSR
ASGFAGSIFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDK
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEESS------------DATRGVRANS-----------L-SLSAAII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-SSGS-----DYK-------DTP---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSCRSRGGGGGG-GGGG---------------------GSWGFSSGSSS
TAVVSG------SRRSASSSSC--LMRHGGG-----------------------------
---------------------------------------GGGATSRSLIGLG-GS----R
SISISVARKGSG------SYGRGG-AFGG------------GSGFGGGGGFG--------
----G-----G-----------GFGG------------GGGFGGGGFGG---GGRFGPGG
--GFGG-PGGPGGFG------------PGGYPG-GG-I-HE-VT----------VN-Q-S
L--LEP-LN-VK-ID-PE-FQ-NVK-SE-E------------------------------
------R-EQI-KK-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LTT-KW-EM-LQQIDV---ST--RSPNLEPLFEMYISSLKQN----VDTLVTEK
-----------TKQDS-----ELNNMQDLVEDFRK--KYEDEINKRTSCE--NDF-VTIK
KDVDN----AYL-KKVDLETQVNMLR---EEADFLRVLHETELS-QM-QQNITDTNVIL-
-SMD-------------------NNRSLDL--------ESIIKDV-QSQYEEIAKRSKIE
AENLYHS---------K----YEEL-QI-TAGKHGE-SLKEIKM--------------EI
SELNRMIQRLQGE--I---------AHVKKQ-----------------CRAVQD----SI
ADAEQRGEHALKDARHKLEEL---------------EEALQQAKEELVRL-------LR-
------DYQELMNTK-------------------------------I-SLDLEIATYRKL
LEGEEDR------------ISGEVP--SNVS---------ISIS----------------
-------SST----------------------------ISSSVASKAGFRGSGG------
---------G----------------------------G-GGGYGSGGRGSG------SG
G-G---GG-GGGYGSGGRG--SSS--GGGGYGSGG-------------------------
---------RGSS-------SGGGGYGSGGRGSGS-GGG-----------------GGGY
GSGGSS-SGSREFSSGG--------G-------------SGGRSS---------------
-----SSGGRVSG--S------------------GGG----------------------G
SSSAGGGPGXXXEA---------C---------------------------------DTS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
RISFNVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKKQ-----------------RASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------TGADLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------SGQTKTTEERGG-----DLK-------DSQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------TTSSS---TRRSG-------------------------------
---------GGGG-------RFSSC--------GGGGGGGGGFGSRSLINFG-GGGGGGR
SFSQSVIRGGGCGGGFGGGG-GGF-G---------------GGSFGGGYG----------
------------------SG-GGFGGGGSFG-------GRGG----FGR---GGGFGGGG
----FGGGGMGGGFG------------GAC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PQ-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--KTHSLEPLFEQYISRLSQT----VNKLKSDQ
-----------SRMDS-----ELKNMQDLVEDFRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYL-NKADLQGKAGLLQ---QEIDFFTTLYQL---------------VIL-
-SID-------------------NHRSLDV--------YSLITEI-QAQYVDIAQKSQAE
AESVYQS---------K----YEEL-QI-TAGKHGD-SVKSSKM--------------EI
SELNRLIQRLRSE--I---------DSVKKL-----------------ISQLQQ----SI
SDAEQRGENALKDAKDKLNEL---------------EDALQKAKEDLARL-------LR-
------DYQELXXXX-------------------------------X-XXXXXXXXXXXX
XXXXXXX------------MSGECS--PNVS---------VSVS----------------
-------TSH----------------------------TTISGGGSRGGGG-----G---
----------------------------------------GGSYGSGGGGGG------SY
G-SGGGGG-GNYGSGGGGG----------------------------------GSYGSGG
GGGGGSYG----SGGGGGSYGSGG--GGHKGGSGGRGS-------GGGSSGGSYGSSGGR
G-----------SSSGGTKTSS--------------------------------------
--------GSSSV--K-----FIST-TYSR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFSSRSRFRSG------------------------------GGFSSGS--
AGVVSF------QRRSTSSSV----RHSGG-GGG--------------------------
---------RFSG-------GRCGGG-------GG----GGGFGSRSLVNLG-GS----K
SISISVARGG-GRGGFGSGY---G--GG---------------GFGGG------------
-GFGGGGFGG-G----YGG-------G-GFGGGG--FGGGGFGGSGFGG----GGFG-GG
--GFGG-----GSFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-TQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESYINNLRRR----VDQLKSDQ
-----------SRMDS-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-TKVDLQAKVDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-NLKSTKM--------------EI
SELNRVAQRLRSE--I---------DSVKKQ-----------------ISALQQ----SI
SDAEQRGENALKDAQGKLAEL---------------EDALQKAKEDMARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECT--PNVS---------VSVNTSHT------------
---------------------------------------TISGGSSRG--G---------
-------------------------GGF--------GSG-GGGS--GGGYGS-----GGG
SYGS---GG--------SS-----------YG----------------------------
-SGGGGGGSYGSGG-GGGGGGYGS-GSSSGGHRGGSWGS---------------------
----------GGGSSGGRGSS-----------------------------------SGGT
K----TSSGSSSV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------AVR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSQSLYSLG-GN----R
HISFNVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGRGR
ASGFAGSMFGSVALG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQ-----------------------------------------
--------------------------------------YEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQIFSVSN---EPAPCPLWRASLET----AI
ADAEERGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------VGTDLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------NGQTKTTEMRGG-----DLK-------DSQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------ARGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---CP----SLCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-ME-LD-RE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYTSNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDALD---EEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIAWKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRFIQRLRSE--T---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYINSVS-----------ISVINSSVA---G-------
---------------------------------------------TAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTVR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
RISFNVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVDLG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKKQTFSVSN---EPAPCPLWRASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGVDLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------SGQTKTTEVRGG-----DLK-------DSQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PRG------------------------------ERLGFSGCS--
AVLS-GG-------IGSSSASF----RA-R------------------------------
----------------------------------VK--GSASFGSKSLSCLG-GS----R
SLALSAA----ARR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTAFGSAGLG-PK---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-MD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLQKQ----LEMLSGDG
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIT-QI-QSHISDTSIVL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CADLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELVSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSVPS----ARAPR---GFSARSA-----------------------------------
----------------CCARSRS----WG-RG--------GRFSSRSCTSFG-GS----R
G-GS-RG-----------------------------------------------------
-----RAWGSGG--R-PG-V---------------------------------Q-S-G--
-------G-AR-G-G-PG-L-P-----L-CP-P-GG-I-QE-V---------T-ID-T-A
L-L-SP-LN-IG-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RS-LN-DQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KI-LET-KW-QL-LQQ--Q---GVRDSPPDLETFFEGYVAQLRRQ----LEQLQSER
-----------KAVDA-----ELKSCQDQEEEYKA--KYDEEAHKHATAE--NDF-VVLK
KDVDG----VFL-SKMELEGRLQSLR---EYVCFLRRLYEEELG-RL-QTQAGDTSVVL-
-SMD-------------------NNRGLDL--------GDIIAEV-GARYEEIARSSKAE
AETLYRT---------Q----YQEL-QA-SARLHGD-SMKGTRV-------------R-I
SQLQEASQRLQGQ--I---------ENLRTQ-----------------NANLQA----TI
TDAEQRGELALKDAQTKLAEL---------------EAALRATKQELARL-------LH-
------EYQELMSTK-------------------------------L-ALDVEIATYRRL
LEGEESR------------MSGRCTSQVVVS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVLSGGAGSGL-GGSCGLGGEKGSFGS-SCSSVV
TGGSTITVGSG---------------------QGPVLASCSVSGSGS----GSGSSCRTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYARGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISISLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RSFGV-----------GS-----IGAG--------GFGGG--------------GFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRRQ----VDLLNAEQ
-----------MRQNT-----ELRSMQEVVEDYKS--KYEDEINKRTGSE--NDF-VILK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTIQRLQAE--I---------SNVKKQ-----------------VGWMQS----LI
SD------QALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VNISGGAGGGGSY-----GSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSS---GG-------GGES-----------------------------------YGGSGR
R----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
ASLLSG------CRPGFSSVS---VSQSGKSF----------------------------
-----------------------------------GGGFGGGFGTRSLHSFG-GN----K
RISIGGG------------YRSSRAS---------------FGG------------AACG
LGVSGI-----G----YRVG---------------------GAYGGYG------------
-------FGG--G--------------MAP-GA-GG-I-HE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------K-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQDH-----KT--TRTNLEPMFEAYITNLRRQ----LECLGGER
-----------GRLET-----ELKSMQDVVEDFKN--KYEEEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVDALM---DEISFLRAFYEAELA-QL-QAQISETSVVL-
-SMD-------------------NNRSLDL--------NSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QR-SAGQHGD-DLRTTKM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CATLQA----SI
ADAEQRGELALKDAKHKLAEL---------------EEALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LTGEGV--GAVN---------ISVV----------------
-------SSS----------------------------GGSGYSGGGGLCMSGGS-----
-----------------------------------YSGG------GG-------------
-----------GYSGS--G--------------------------------------LCY
G------------------GG------------G-----SGGF---------SSTSGR--
------------------------------------------------------------
-----SVSGSSSS--M----RIVSK-TSSSK-----------------------------
------------------------------------------------------------
---------------KSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GGG--FG------------GGSGFGGGSSFGGGSGFGGV
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG--G-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AESLYHS---------K----YEEL-QV-TAGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVTSKAGFG----GSGGRE
SSSG--G---------------------------GYSSG-SSSYGFGGRRS-------G-
--------------------SRGG--GGGGG-----------------------------
---SISGGGYG----SG--SGSGGRYGSGGGSKG--------------------------
------------------GS--S-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------D------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIGSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTST---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GTSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS--------------------------------------
RRV---------------YST----RSSAGSGGG--------------------------
---------SRTVGSVCQARGRCGGSSGGGGFGSGYWSHGGGFGSRSLYNLG-GS----K
SISVSLTGRGG--SGFRQGWGGGR--FG------------RGLSFATG------------
-RFGGGGYGGGG----FGA-------S---------------------------NF----
---------ALGGFG------------PSC-PP-GG-I-QE-VT----------IN-S-S
L--LEP-LH-LE-VD-PE-IH-KVK-TK-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RSHNLEPLFEAYISNLRNR----IDQLKSDQ
-----------SRMDS-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-NKVDLQAKVDTLQ---QEIEFYTTLFQMELS-QV-QTDISQTNVVL-
-SMD-------------------NNRSLDL--------GSIIAEV-KAQYEDIAQRSKAE
AESLYQT---------K----YEEL-QI-TAGRQGD-SVKNSKM--------------EI
SELNRMIQRLRAE--I---------ESVKKQ-----------------IASLQQ----SI
SDAEQRGENALKDAQNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDIEIATYRKL
LEGEESR------------MSGECT--PNVS---------VSVSTSHT------------
---------------------------------------SISGGSSRG--G---------
-------------------------GGY--------GSG-GGG-----GYGS-----GGG
SYGS--------------------------------------------------------
-GGGGGGGGYGSRG-GGGGGSYGS-GGSSGGRRGGSGGGGG-------SSGGRVSGGG--
------SSGGSFSSSGGRGSS-----------------------------------SGGT
K----SSGGSSSV-------KFVSA-TYS-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQLAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGARAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSTKTTIKS---QT----------------------------SHRGYSASS--
ARVPGL------NRSGFSSVS---VCRSRGSG-G--------------------------
------------------------S--------GAMCG-GTGFGSRSLYGVG-SS----K
RISI--GGGS-CGIGG--GYGSRFG-----------------GGFGTGG------GAGS-
-----------G----FGFG-------------------------------------GGA
--GFGGGYGG--AGF------------PVC-PP-GG-I-QE-VT----------IN-Q-N
L--LTP-LN-LQ-ID-PT-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-D-------------------------------
------------------------------------------------------------
------------------------------------------------------------
KDVDA----AYM-TKVELQAKADSLV---EEINFLRVIYEAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRSLNL--------DSIIAEV-KAQXEDIAQRSRAE
AESWYQT---------KVSIGYEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDARGKLEGL---------------EDALQKAKQXMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GPVN---------ISVV----------------
-------QST----------------------------VSSGYGSAG--GA---------
---S-----------------------------S--------------------------
------------------S--------------------------------------LGL
G------------------GGSSYSYGSS--RGL----GG-GF---------SAGSGR--
---------------------------GI---------------------------GGGL
S----SSVGSSST--I----KYTTS-ASSSR-----------------------------
------------------------------------------------------------
---------------KSYRH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------SSRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GG----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDTMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYS------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGENRSR-GSSS-----DYK-------DTL---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
RISFNVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVDLG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKKQTFSVSN---EPAPCPLWRASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGVDLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------SGQTKTTEVRGG-----DLK-------DSQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------RYEDEINKRTAAE--NEF-VVLK
KDVDA----AYM-GRVDLQAKVGTLT---EEINFLRCLYEAVRS-PA-TGQSWDRSDLLL
-CND-------------------WTRALRP--------LGRIVFP-ISQMEKLTPRSRTE
ARVLYQS-------------QYEEL-QV-TAGKHGD-HLRDTKN--------------EI
SELTRTIQRLQSE--I---------DTAKKQ-----------------CQQLQT----AI
ADAEQRGDMAIKDAQAKWADL---------------EAALHNSKEELARL-------LK-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LECEESR------------APAR------------------------F--LPGLLST---
--------------------------------------------AVSG------------
-----------------------------------SSSTV----SGGGCRVGF-----GG
---------------------------------SVSS-----------------------
------------GVKGGYGS--------------------GYSSGYGS------------
--------------VGGGGG--G-YGV------AKGGS----------------------
-----------------------------------------------GPGS---------
---------------------------------------------------------TSV
IKKSMTTT-VKSSSRR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLHSF-PGS------------------------------ERLGFSGCS--
AVIS-GR-------MSSSSASF----RA-G------------------------------
----------------------------------VK--GTTAFGSRSLFSLG-GG----R
RLALSAS----AGR-SG------------------------AFALSHC------------
------------------------------------------------------SGTGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PK-IQ-KVR-VQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-SL-LQQLDV---NS--CRKNLEPVYEGYISSLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKN--RYEVEINRRTTAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLNLTK--------------AEI
SELNRLIQRIRSE--I---------ASVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALNQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTGA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKPG--------A-
------------------E-------LKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPL---TKA-------S--SSSCAT
KKKASR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQSKVESMD---QEIKFFKCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALXXXXX
XXXXXXXX-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKK-----------------QISGLET----SI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSPVS-----------IXXXXXX-------------
------------------------------------------------------------
--------------------------------------XXXXXXX-XXX-----------
-----------------XX-------XXXXYVA---------------------------
----NSTSCIS-----------G------------------------------VCSIR--
--------GGEGRSRSS-AS-----DYK-------DTV---GKG------S---SLTAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--MSQQLSIKSRG--D----------------------------------KGGFSGRS--
AVVLR---------------------K---------------------------------
------------AVG---SAPS---------YRAAGKGAGAGFGSRSLYGLR-NQ----C
SSLSAGGGV---------------------------------------------------
----WTSY------S-FGLGS-G----X-------------------------------X
---XXXXXXXX------X---XX----XXXX-X-XX-X-XX-XXXXXXXXXXXXXX-X-X
X--XXX-XX-XX-XX-XX-XX-XXX-XX-X------------------------------
------X-XXX-XX-XX-XX-XX-XXX-XX-XRF-LE---------------------Q-
QN-QV-LET-KW-AL-LQQLDL---SN--CKNHLEPILERYIGNLRK----QLEALSGDR
-----------VRLDS-----ELGNVRDVVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-AKMELQAKVDSLD---KDIKFLKCLYDAEMG-QI-QTHTSETSVIL-
-SMD-------------------NNRDLDL--------DSIITEV-RAQYEEIALKSKAE
AEALYQT---------K---XXXXX-XX-XXXXXXX-XXXXXXX--------------XX
XXXXXXXXXXXXX--X---------XXXXXX-----------------XXX-------XX
XXX-----XXXXXX-XXXX-X---------------XXXXXX---XXXXX-------XX-
------XXXXXXXXX-------------------------------X-XXXXXXXXXXXX
X---XXX------------XXXX------------------------X--XXXXXXXX--
----------------------------XXXXXXXXXXXXXX-XXMSGEN----------
---------------PSSVS--------I-----SVSSSS-T--SGFGYHPGS-----SA
---------------------------------SANLG----------------------
-------------ASATVGS--------------------SGSTRGGQ------------
--------------TRAKGA--R-AGD------PEDSQ----------------------
-----------------------------------------------G--E---------
---------------------------------------------------------SAP
V---------TGPARKAARK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GP----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDTMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYS------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGENRSR-GSAS-----DYK-------DSL---TKG-------S--SLSTPS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------RKGGFSGCS--
AVLL-GG-------T---ASSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSQSLYSLG-GA----R
TISFNVASG--SGR-PG------------------------GY-----------------
------------------------------------------------------GLGRGR
ASGFAGSMFGSVALG-PA---CP----MVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAS-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKDNLEPILEGFIANLRKQ----LEILSGDR
-----------VRLDS-----ELRSMREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---REIKFFKCLYEGEIS-QL-QSHISDTSVIL-
-SMD-------------------NNRKLDL--------DSIISEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-EL-VAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLEM----AI
ADAEQRGDCTLKDARAKLDEL---------------DGSLHQAKDELARM-------LR-
------ELQQLLNSK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNAVS-----------ISVISSSTA---G-------
---------------------------------------------PSGTGTG--------
-----------------------------------FGFGSAGTYG-YRP-----------
-----------------SS-------VCGGYGM---------------------------
----MSGGCVT-----------------------------------G----SGNFSPR--
--------GGEAKTKLGSAS-----EFK-------EPP---GKT-------S--ALSSPT
KKSTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQALVSVSQ--SRRYGGDY-----------GGGFSSRSLYSLG-GS----K
SIFGNLVGRSASG--FCQSRGP-------------------GGGFG------------GG
IGGGI------------GGG-RGFGGG--------GFGGGYGGGGRFG-----GGFG---
-----GAGFGFGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPVFEEFISQLQRQ----VDVLTTEQ
-----------LRQNT-----EIRNMQDVVEDYKN--KYEDEINKRTNAE--NDF-VVLK
KDVDA----AFM-GKSDLQSKVDTLY---GEINFLKYLFDTELS-QI-QTHVSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RAQYEIIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNIQRLRAE--I---------ANIKKQ-----------------VEGMHG----LI
SDAEERGERALQNAKQKLQDM---------------EEALQQAKEDLAKL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGALQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTIGGGGGGSGSY-----SGSS
-------------------------------------------RGGGG------------
------------------------------------------------------------
-----------------------GGGGT--GSRGGGGG----------------------
------GGGSS-YVSS-SRS--------------ATKYGS--------------------
------GGGSSRT-------QILQT-STH-------------------------------
---------------------------------------------------------SSR
RHVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------HRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYG-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSNRSSCRIGG---------------------------G-RGFSSGS--
AGLVSF------HRKSTSSSV----RRSGGGGGG--------------------------
---------RFSG-------GFCGSS-------GGS---GSGFGSKSLVNLG-GG----R
SISMSVAGGGH-CGGMGGGS------------------------FGGG------------
-SFGGGGFGGGG----FGG-------G-GFGGGFGSG-GGGFGGGGFGS---GGGFG-GG
--GYGG-GRFGGGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-ME-VD-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTHNLDPYFETYIANLRKQ----VDQLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVELQAKLDNLQ---QEIDFLTALYREELS-QM-QTHISETNVIL-
-SMD-------------------NNRTLDL--------DSIISEV-KAQYDDICQRSKAE
AETFYQS---------K----YEEL-QI-TAGKHGD-SVKTSKM--------------EI
SELNRVIQRIRSE--I---------DSVKKQ-----------------IAHMQQ----NI
SEAEQRGENALKDAQKKLNEL---------------EEAMTQAKEELARL-------LR-
------DYQELMNTK-------------------------------L-ALDME IYKGAL-
L--------------------GGKG--V DLS---------AAVSTSHT------------
---------------------------------------SMSGSSSRG--G---------
-------------------------GGY--------GSG-GGSYGSGGG-GG-----GYG
GSS----GG--------GS-----------YG----------------------------
-------GGSGSGG-GGGGGSYGGSGGSSGGHRGGSGGGGG-------SSGGSYGSS---
--------G-----GGRGGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG-------GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGSG----IGG-------G-GF----GGFGS---GGGGFGG----G------
----------------------------------------E-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDG----AYM-TKVDLQ-ELDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVRNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------ISNLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEEID------------FSGACA--GFVG---------LEMDTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GSSYGSGGGSYG-S----G-
---GGGGGGRGSYGSGGSS-----------YG----------------------------
-S---GGGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PRR------------------------------ERLGFSGCS--
TVLS-GG-------IGSSSASF----LA-G------------------------------
----------------------------------VK--GSASFGSKSLSCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---NN--CRKNLEPIYEGYISNLQKQ----LEMLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIT-QI-QSHISDTSIVL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEVTLKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELVSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKAFR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------SKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GI----R
SISFNMANS--TGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISTLRKQ----LEALSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------T--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGETRSR-SSTT-----DYK-------DAL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYLSNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--KYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLL-AGG------------------------------ERLGFSGCS--
AVLS-GR-------FGSSRSSF----RA-G------------------------------
----------------------------------AK--GATPFGSRSLFSLG-GS----R
RQARS-A-G--LER-GG------------------------GFALGHG------------
------------------------------------------------------GAASGR
PGGFVGTIFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-VE-LD-RE-IQ-KVR-VQ-EREQIKVLNNKFA------------------
------------------------SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKKLEPIYEVHISSLRKQ----LEALSGDR
-----------VRLES-----ELRNMQDIVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKIDLQAKVDSLT---EDIKFFKYLYEEEIV-QM-QSHVSDTSVIL-
-SMD-------------------NNRDLDL--------GSIIDEVR-VQYEEITQKSKAE
AECLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SEVNRLIQRLRSE--I---------GNVKKQ-----------------CSNLET----SI
TDTEQQGDCALKDAQAKLHEL---------------EGALQQGKEELVRL-------LL-
------EYQDLLNVK-------------------------------M-ELDIEITTYRML
LEGEESR------------MSGDHPNSMS-----------VSVISSTTA---G-------
-------------------------------------------TGGAGFSVG--------
-----------------------------------FGAS--SNYS-YKPA--------A-
-----------------VD-------VKTKS-----------------------------
------------------------------------------------------------
--------------NHVSVS-----ELK-------DPL---SKT-------S--GSSCGP
RKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQLAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGARAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPH--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSASS--
---------------------------SAAS-GGG-------------------------
---------SRAVGSVCHAQGRCGG--------GGYGSHGRGFGSRSLYNLG-GS----K
SISINLVGRRASG--FRQGWGS-------------------G-GFG------------GG
RGFGV-----------GS-----IGAC--------G---------GFG----GGGSGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TR-E------------------------------
------R-EQL-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTNNLEPLLESYIGDLQRQ----VDFLNAER
-----------MRQNT-----EVGSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLQSRVDTLT---GEVNFLKHLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RIQYELTAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SSIKKQ-----------------IEQMHS----LI
SDAEERGERALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------WVQQLCSWGQGL---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----GPGG
-------------------------------------------YGGG--SG-GGYGGGSS
R-------------G---------------------------------------------
---------------GGG------RSYGGGGSR-GGSGG-------------------GY
GSG-------------GGA-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PGG------------------------------ERLGFSGCS--
AVLS-GR-------MGSSSASF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCPG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SMCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIAQRSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALYQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------TGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GGSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAAGGFGG------------GSGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG--G-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RPINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QEIEFLKVLYDAEIS-QI-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AEALYHS---------K----YEEL-QV-TVGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEEFI------------ISV-VT--PPLS---------AAVT----------------
-------SST----------------------------ISSNVTSKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRQS-------G-
--------------------SRGG--GGGGGS----------------------------
----ISGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--I-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGVS------------S-
---SVK--GSSSEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCRISSRSRGR-GG--GGGG---------------------GFRGFSSSS--
AVGSGG------SRRSTSSFSC--LSRHGGGG----------------------------
-----------------------------------RGVGGGGFGSRSLVGLG-GT----R
SISISVAGGGGSFGSGGGFGGRGG-GFGG------------GIGFGGGS-----------
----------------------GFGGG-------SGFGGGGFGGGGFGG----GRFGGGS
--GFGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VG-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVHV---GT--RTSNLEPIFQAFIAQLKRQ----VDTLCAER
-----------TSQDS-----ELNSMQDLVEDFKK--KYEDEINRRTAAE--NDF-VTLK
KDVDN----AYK-IKVDLQAKVDVLT---QELEFLRILYDAELS-QM-QQSISDTSVVL-
-SMD-------------------NSRHLDL--------NSIIAEV-RAQYEEIAQKSKAE
AEALYQS---------K----YEEL-QI-TAGSHGD-SLKSTKM--------------EI
SELNRVIQRLRSE--I---------DSVKKQ-----------------IAALQQ----SI
SEAEQRGENALKDAQNKLNEL---------------EAALQRAKEDLARL-------LR-
------DYQELMSTK-------------------------------L-ALDVEIATYRTL
LEGEEGR------------MSGECA--PNVS---------VSVS----------------
-------TSH----------------------------TSISGGGVRGG-GG-F------
--S---S--GG---------------------GGSYMSG-GGSYSS--------------
G-G--G-G--GGFGSGGSS--RGH------------------------------------
-------------------------RGGSGGGSG------------------------S-
-------YGVRI---SG--------G---------------------------GGSGGSF
S----SS---------------------------GGRGVSSGGS----------------
----------KSSG---------G---------------------------------SSS
---------VKFVSS-SYSQGSR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSWQRN-INSRG------------------------------NKGNFSVHS--
AVMP-KK-------AMGSVAFY----HATA------------------------------
-----------------------------------QGA-GAGFSSQSLYNLG-GN----R
RIFSNVADR--GVW-AG------------------------GHSFEHG------------
-----------------------------------------------------SGYGSSQ
SRGFPGSMFGSVALG-PG---CL----SVCP-P-RG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKNLEPTYEGHISGLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDVAEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADV----AYT-AKVELQAKVDSLD---KDIKFLKCLYDAEIT-QL-QTHASDTSVIL-
-SMD-------------------NNRDLDL--------ESIITEVH-THYEDIAWKSKTE
AEALYQTK-------------FQEL-QL-VAGQHGD-DLKHTR--------------NEM
SELNRFIQRIRCD--I---------ISVRK-----------------QCSNLET----AI
TDAEQRGDSALKDAQAKLDEL---------------EGALHQAKDELARM-------MH-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGGNPSSVS-----------IAISSSS-------------
------------------------------------------------------------
------------------------------------------GSG-YHP-----------
-----------------SS-------VSTDLGV---------------------------
----SSAA-------------------------------------------INLGSPR--
--------SGQTKTQGAQAG-----DLR-------DSQ---DKS------AS--GSAPAR
KTTR--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFNCKS---------------------------------SKGSFSGRS--
AILP-GG-------RGASSGSY----RAGS------------------------------
------------------------------KATAAAGV-VGGFGSRSLYSLG-GT----R
SISLNVR---------S------------------------GYGFGAG------------
-----------A-------G--------------------------------GCGPGRVR
ASGFAGSMFGSVALG-PA---CP----SSCP-P-GG-I-HQ-VT----------V-NQ-S
L--LQP-LD-VK-VD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-DL-LQQLDL---SN--CKNNLEPIFEGYISNLRRQ----VEGLNGDR
-----------VRLDS-----ELRSVRDLVEDFKKRRRYEEEINRRTAAE--NEF-VVLK
KDVDA----AYT-NKVELQAKVDSLD---GEIKFLKCLHEAEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIDEVR-VQYEDIALKSKAE
AEALYQTK-------------FLEL-QL-VAGRHGD-DLKHTK--------------NEI
SELSRLIQRIRSE--I---------ENAKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKLDDL---------------EGALHSAKEELARL-------LR-
------DYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDFPSSVS-----------ISVISSTSG---P-------
------------------------------------------------------------
--------------------------------------SGSTGYG-YRP-----------
-----------------SA-------VSGGYAV---------------------------
----SSGYAVS-----------G------G------------YAVSG----GGSSSSG--
--------ARAGEARRGSAS-----DFK-------DAL---AKG-------S--SLVSPT
RKSPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

-------------------------------------------LDRARMAGSGDSPFPNL
SRVPSSMTSRQQSVR-------S--------------------------SSRGFSCGS--
AAVTCG------RRSGFS------AAS---------------------------------
----------------------SGA--------GCRGSGAGAFGSRSLFNLG-GN----K
SISISVAGARQNAGGFGAGGFGAG-G------------------FGGGIG---------G
F-----------------GV-GGFGSG---------------------------AFGG--
-----QIGGKGSGGF------------PVC-PA-GG-I-QA-VT----------IN-Q-S
L--LAP-LN-LE-ID-PE-IQ-KVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-NL-LQQQGT---TT--TSKHLEPFFEAYISTLRKQ----LDNLLSDK
-----------GRLQS-----ELKTMQDTVEDFKS--KYEEEINKRTTAE--NDF-VVLK
KHP------GFL-LGIQLYHKINNTI---WTLTHLFAHLAKKRA-QI-QTTVSDRWVIV-
-SMD-------------------NNRCLDL--------DSIIAEV-KAQYEEIAQRSKAE
AEALYQT---------K----FQEL-QS-SAGKHGD-DLKSTKM--------------EI
SELNRLIQRLRAE--I---------ENVKKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------LSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RLALSS-----AGR-SG------------------------GFTLGHG------------
------------------------------------------------------GASGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDQ---NN--SKRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKVLFEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILAEVR-AQYEEIALKSKAE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKHTK--------------SEI
TEINRLIQRIHSE--I---------GNMKKQ-----------------CSNLET----TI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MAGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGAS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPP---AKT-------S--GSSCAT
KKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------MTQRSSSVTIK--SG----------------------------GTRNFSASS--
ASLLPG------CRPGFSSVS---VSQSGKSF----------------------------
-----------------------------------GGGIGGGFGTRSLHSFG-GN----K
RISIGGG------------YRSSRAS---------------FGG------------TACG
LGVGGI-----G----YRVG---------------------GAYGGYG------------
-------FGG--G--------------MAP-GA-GG-I-HE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------K-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQEH-----KT--TRTNLEPMFEAYITNLRRQ----LECLGGER
-----------GRLET-----ELKSMQDVVEDFKN--KYEEEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVEALM---DEINFLRAFFEAELA-QL-QAQISATSVVL-
-SMD-------------------NNRSLNL--------DSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QR-SAGQRGD-DLRTTKM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CATLQA----SI
ADAEQRGELALKDAKNKLAEL---------------EDALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LTGEGV--GAVN---------ISVV----------------
-------SSS----------------------------GGTGYSGGGGLCVSGGG-----
-----------------------------------YSG--------G-------------
-----------GYSGS--G--------------------------------------LCY
G------------------GG------------G----SSGGF---------SSTSGR--
------------------------------------------------------------
-----SVSGSSSS--M----RIVSK-TSSTK-----------------------------
------------------------------------------------------------
---------------KSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSAHSA-----------------------------------
----------------CSAFSGA-----------RG---RTGFSSRSLSSSR-RC----R
G-SS-CG-----------------------------------------------------
-----RAWGAET--R-QG-I---------------------------------R-F-G--
-------Q-GK-G-G-PG-F-S-----Q-CP-P-GG-I-QA-V---------T-VD-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TR-EI-RS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLECIFETCLARLRQQ----LEELQRER
-----------RALDS-----ELKTYQDQEDEYKS--KYDQEAYKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGNLESLK---EHVCFLTRLYEEELR-QL-KTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITRTSKAE
AEAVFQT---------K----YQEL-QE-SAQLQGN-SMKEAQV-------------Q-I
SQLRQAIHRLQSQ--I---------GSLRKQ-----------------NDSLQS----AI
ADAEQQGEMAVRDAQAKLDEL---------------EAALRTAKQDMAQM-------LR-
------DYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISKEHTSQVTVS----------------I--TEGSIVP---
---GRTCGGQ-----------------VTVP-------------------G---------
REY---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------GGQVTVPGRESGGQVTVPGRESGGQV
TMPGR-------------------------------------------------------
-------------------------------------------------------EYGGQ
VTMPGRES-GGQVTVPGREYG---------------------------------------
----------------------------GQVTVPGRES----------------------
--------------------------------------------GGQVTMPR--------
------------------------------------------------------------
------------------------GEWSMP-RGECGGQVGTCGHRGWQGSFGSGGCSSIV
TGGFEIPQGSG---------------------YSPTMGSCSVSGSGFSSGS--GSSCRTI
LKKTVESSRKMSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
SVSSTDL-------------QYEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CTNLQT----AI
ADAEQSGELALKDARNKLEGL---------------EDALQKAKQDMVRL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIAIYRKL
LEGEECR------------LNSE------------------------G--VEPVSICK--
----------------------------YLASLPALPQILLV-TWFIGQNA---------
HHAL----------CPCSLP--------KA----MVQSTI-F--SGHGKANGM-----DG
---------------------------------GIGLS----------------------
---RGSS--YCFRSGHSLGS--------------------SFSSGSG-------------
-----------------RGV--Y-IGV------CPSST----------------------
-----------------------------------------------G-DS---------
---------------------------------------------------------SST
IKYTS----SSSR-RKNNKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRRGGGGGGGGGG---------------------GFRGFSSGS--
AVVSGG------SRRSNTSFSC--ISRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISSSVAGNSGG--YG------GS-SFGG------------SSGFGGVRGFGSSHGFGGS
GGFGGG----SG----FGGG-RGFGSSHGFGG-GSGFGGGGFGGGSFGG----GRFGGGP
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GS--RTTNLDPIFQAYIGMLKKQ----VDRLSAER
-----------TSQES-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NDF-VTIK
KDVDS----CYM-DKTELQARLDILA---QEVNFLKTLYDAELS-QL-QQDVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QSQYEMIAHKSKAE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHAIKDARGKLTDL---------------EEALQQCREDLARL-------LR-
------DYQELMNTK-------------------------------L-SLDVEIATYRTL
LEGEECR------------MSGDFS--DNVS---------VSIT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GGR---------------------GGG-GGG-GSTYGSGGRSSG------SR
G-SGS-GS-GGGYSSGGGS--RGG--SGGGYGSGG-------------------------
---------GSSS--------GGGGYGSGGGSRGG--SGGGGVSSGGGSRGGSS------
------------------------------------------------------------
-----SGGGSRGG--S----------------SSGGGGYSSGGGSRGGSS------SGGA
GSSSEKGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSLQCSSRSLCRSGGG--------------------------G-RNFSSGS--
AGLVSF------QRRSTSSSM----RRSGGGGGG--------------------------
---------RFSGG------GFCGSS-------------GSGFGSKSLMNLG-GG----R
SISKSVAGGGG---SFCG-GFGG----G---------------SYGGG------------
-GFGGGSFGGGG----FGG-------G-SFGGGG--FGGSGFG-GGLGG---GGGFGSGG
--GFGG-GRF-GSMG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PQ-IQ-KVK-SQ-E------------------------------
------R-EQI-KS-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTQNLDPFFENYISILRRK----VDSLKSDQ
-----------SRMDS-----ELKNMQDLVEEYRT--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVELQAKADALQ---QDIDFFSALYQMEMS-QM-QTQISETNVVL-
-SMD-------------------NNRSLDL--------DGIISEV-KAQYDSICQRSKAE
AETFYQS---------K----YEEL-QI-TAGKHGD-SVRNTKM--------------EI
SELNRMIQRLRSE--I---------DGCKKQ-----------------ISQIQQ----NI
NDAEQRGEKALKDAQNKLNEI---------------EDAMSQCKEDLARL-------LR-
------DFQELMNTK-------------------------------L-ALDMEIATYKKL
LEGEEI R------------MSGECT--PNVS---------VSVSTSHT------------
---------------------------------------SMSGSSSRG--G---------
-------------------------GSG--------GGR-YGGGGSYGG-GS-----GGG
SYGGSSGGG-----GSGGS-----------YG----------------------------
-GG-SGGGSY--GG-GSG-------GGSSGSHRGGSGGGGG-------SSGGSYGGSS--
------GGGRGG------SSS-----------------------------------GGGG
V----KSSGSSTV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GTK-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQSTITFH--SG----------------------------SRRGFSTAS--
ATTPTA------GRSRFSSVS---VARSSGNSGG--------------------------
------------------------L--------GRISGIGSGFGSRSLYNLG-GT----R
RVST--GGCAGSGFRG--GFGGRAS-----------------GGFGG----------SS-
-----------G----FA---------------------------------------YGG
--GIGGGFGG--PGF------------SVC-PS-GG-I-QE-VT----------VN-Q-S
L--LTP-LN-LQ-ID-PT-IQ-RVR-KE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-NL-LQEQGS---RT--VRQNLEPFFDAYVNDLRRQ----LDGVTAER
-----------GRLDA-----ELRNMQEVVEDFKV--RYEDEINKRAAAE--NEF-VGLK
KDVDS----AYM-NKVELEAKVDSLT---DQINFYRMIYEAELS-QM-QNQVSDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
SEMNRMIQRLRSE--I---------DAVKKQ-----------------CSSLQT----AI
SDAEQRGELALKDARAKLMEL---------------EDALQKAKQDMARL-------LR-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LSGEGV--SPVN---------ISVV----------------
-------TST----------------------------VSSGYGGGANIG----------
---G-----------------------------G--------------------------
------------------S--------------------------------------LGL
G------------------GNSGYTFTTNGGHSL----GT-GL---------GGS-----
--GF-----------------------TT---------------------------SSSR
G----PVG-SGSS--I----KFVS--STSSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MPLSP----CRAQR---GFSTRSA-----------------------------------
----------------CSTRSRG----CS-SV---------GFSSRSLNSFG-GC----L
R-GS-CW-----------------------------------------------------
-----STWGSGG-----------------------------------------R-F-G--
-------E-QS-G-G-PG-L-S-----L-CP-P-GG-I-QK-V---------T-IN-Q-N
L-L-TP-LK-ME-ID-PQ-FR-VAR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VQF-LE---------------------Q-
QN-KV-LET-KW-CL-LQQ--Q---GVRGRPQGLEPVFEACLAQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYQEEAHRRTTLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYICFLKRLYEEELA-QL-QNQDSDASVVL-
-SMD-------------------NNRHLDF--------SSIITEV-RARYEEIAWTSKTE
AEALFQT---------K----YREL-QV-SAQIHGN-SIQETKV-------------E-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQG----AI
ADAEQHGELALKDAQAKVDEL---------------EAALRMAKKNLAQL-------LR-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LESEEYR------------MSGECPNQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVVSGGVGGGL-GGTCGLGGGKGSSGS-RCTSIM
IGGSSILLGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSVCRSG----------------------------G-RGYSSGS--
AGLVSF------QRS-SSSSV----RRSGG-GGG--------------------------
---------RYSG-------GFCRSG-------GG----GAGFGSRSLVNLG-GS----K
SISISVARGG-GRSGFGGGG------------------------FGGG------------
-GFGGGGFGG-G----FGS-------G-GFGGGG--FGGSGFGGGGFGG---AGGFG-GG
--GY-G-----GGFG------------PAF-PP-GG-I-HE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KA-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LKT-KW-EL-LQQVDT---ST--RTQNLEPYFENYISDLRRI----LDQLKSDQ
-----------SRMDS-----EMKNMQDLLEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVELQSKVDLLR---QEIDFYTALYEAELS-QM-QTHISETNVIL-
-SMD-------------------NNRNLNL--------DGIIAEV-KAQYEDIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-SVKNSKM--------------EI
SELNRLIQRLRSE--I---------DSVKKQ-----------------ISNLQQ----SI
SDAEERGEKALKDAQNKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEEI R------------MSGECS--PNVS---------VSVSTSHT------------
---------------------------------------SISGGSVRG--G---------
-------------------------GGY--------SSG-GGSYSSGGGG-------GGG
SYGG---G----------------------SG----------------------------
-SGGGGG-SYS------------G-G-SSGGHRGGSGGGGG-------SS---GGGRG--
------SSGGGFSSSGGRGSS-----------------------------------SGGH
K----SSSGSSSI-------KFVSS-TYSR------------------------------
------------------------------------------------------------
--------------------KY--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-DVDA----AM---NKIEQAKVDAAS---DEIKFLKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------GSIIDEVR-SQYEDIAMKSKTE
AENLYQSK-------------FQEL-QL-AASRHGD-DLKLTK--------------NEI
SELSRLIQRLRSE--I---------ENVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHSAKEELARL-------LR-
------DYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSTMA---G-------
---------------------------------------------NASTGTG--------
-----------------------------------FGLSSASSYG-FRP-----------
-----------------SS-------VSGGYGT---------------------------
----LGGGCV-----------------------------------IG----SGCSP----
--------RGESKTQLSSAN-----EYK-------DAL---GKV------SL--ALSSPT
KKMTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCKSRRGGG---GGGG---------------------GFRGFSSGS--
AVVSGG------SRRSTSGFSC--LSRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISTSVAGCGGG--FGGR---GGS-GFGG------------GSSFGGGGGFGGGSGFGGG
RGFGGS----GG----FGGG-SGFGGGSGFGG-GSGFGGGGFGGGGFGG----GRFGGGS
--GFGG-FG-----G------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---GT--RTTNLDPVFQAYISILKKQ----VDRLTAER
-----------TSQDS-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NEF-VTIK
KDVDS----CYM-DKTELQAKADILM---QEVDFLRTLYDMELS-QL-QQTVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QSQYEIIAHKSKTE
SEELYHS---------K----YEEL-QI-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHALKDARTKLTDL---------------EEAMQQARENLTRL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MTGEFS--DNVS---------VSVT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GG----------------------------G-GSTYGSGGRNSG------SR
G-G---SG-GGGFSSGGGS--RGG--SG--------------------------------
------------S--------GGGGYSSGGGSRGG--SGGGGYSSGGGSRGGSGTG-GGY
SSGGGSRGGSGG-------------G-------------AGGGSRGG-----SGSGGGGY
S----SGGGSRGG--S----------------GSGGGGYSSGGGSRGGSS------SGGA
VSGSERGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--------SCL-KFRTHK--GS--GVGG---------------------GF-HFSRRS--
AVMS-----------SGRSFSCFSLSRRSGCA----------------------------
-----------------------------------RGWGGGGFSSQSRVWAG-QT----E
SISHGVADGG-GLGSDGGFAGRGG-CFGG------------GSGFGGGS------GF---
---GG-----GG----FGG---------------GGFGGGGFGGSRFGGG---GGFGGGG
--GFGG-FGGPGGSG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMDV---ST--RSTNLDPIFQAYIAQLKKY----LDSLSAER
-----------TSQES-----ELSNMQDLVEDFKK--KDEDDIDSRTTAE--NHF-VTLG
KDVDS----AYM-TKVELQSRVDVLS---QEIEFLKVLYDTELS-QM-HQNVTDTNVIL-
-SMD-------------------NNRSLDL--------DSIISEV-QSQYEEIAQRSKME
AEALYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRMIQRLQGE--I---------AHVKKQ-----------------CKSVQD----SI
ADAEQRGENAIKDARNKLTEL---------------EEALQQAREDLARL-------LR-
------DYQELMSTK-------------------------------L-SLDMEIATYRKL
LEGEEC------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSTSS--
---------------------------SAVS-GGG-------------------------
---------SRAVGSVCHAQGRCGG--------GGYGSYGRGFGSRSLYNLG-GS----K
SISINLLGRSASG--FRQGWGV-------------------G-GFG------------GG
RGFRV-----------GS-----IGAG--------GFG--------------GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TR-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTNNLEPLFESYIHALKRR----VDFLNAEQ
-----------MHQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDS----AYV-SKVDLQSRVDTLT---GEVNFLKHLFLTELS-QM-QTHISDTNVVL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELTAQRSKEE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SSIKKQ-----------------IEQMHS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----GPGG
-------------------------------------------YGGG----------GSS
R-------------G---------------------------------------------
---------------GGG------RSYGGGGSL-GGSGG-------------------GY
GSG---GG--------GGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSLQCSSRSLCRGGGG--------------------------S-RNFSSGS--
AGLVSF------QRRSTSSSM----RRSGGGGGG--------------------------
---------RFSGG------GFCGSS-------------GSGFGSKSLMNLG-GG----R
SISKSVAGGGG---SFCG-GFGG----G---------------SYGGG------------
-GFGGGSYGGGG----FGG-------G-SFGGGG--FGGSGFG-GGLGG---GGGFGSGG
--GFGG-GRF-GSMG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PQ-IQ-KVK-SQ-E------------------------------
------R-EQI-KS-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTQNLDPFFENYISILRRK----VDSLKSDQ
-----------SRMDS-----ELKNMQDLVEEYRT--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVELQAKADALQ---QDIDFFSALYQMEMS-QM-QTQISETNVVL-
-SMD-------------------NNRSLDL--------DGIISEV-KAQYDSICQRSKAE
AETFYQS---------K----YEEL-QI-TAGKHGD-SVRNTKM--------------EI
SELNRMIQRLRSE--I---------DGCKKQ-----------------ISQIQQ----NI
NDAEQRGEKALKDAQNKLNEI---------------EDALSQCKEDLARL-------LR-
------DFQELMNTK-------------------------------L-ALDMEIATYKKL
LEGEEI R------------MSGECT--PNVS---------VSVSTSHT------------
---------------------------------------SMSGSSSRG--G---------
-------------------------GSG--------GGR-YGGGGSYGG-GS-----GGG
SYGGSSGGG-----GSGGS-----------YG----------------------------
-GG-SGGGSY--GG-GSG-------GGSSGSHRGGSGGGGG-------SSGGSYGGSS--
------GGGRGG------SSS-----------------------------------GGGG
V----KSSGSSTV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GTK-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSAQSVG-----------RG---RAGFSSRSLSSFG-GC----Q
G-SS-RG-----------------------------------------------------
-----RTWGSWG--R-LG-V---------------------------------R-L-G--
-------E-GS-G-G-PG-L-S-----L-CP-P-GG-I-RQ-V---------T-IN-Q-S
L-L-TP-PK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-QI-RV-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-RL-LQQ--Q---GLSDGPQGLESFFEAYLVRLRTQ----LEQLQRER
-----------GSLDA-----ELKSCQGQEEEYKA--KYECEAYRRATLE--NDF-VVLK
KDADG----VFL-SKMEMESKVKDLK---EYICFLKHLYEEELA-QL-QTQATDMSVVL-
-SMD-------------------NNRCLDF--------RDLIAEV-RARYEEITRTSKAE
AELLYQT---------K----YREL-QA-CAQLHGN-SMKETKV-------------Q-I
TQLQQTIKKLQSQ--I---------ETVKNQ-----------------NASLQV----AI
ADAEQRGELTLKDAQTKLAEL---------------EAALRTAKQDIARL-------LH-
------DYQELMSVK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECASQVTIS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGADGGL-VGSCGLGGVKGSFGS-SCSSIV
KGGSSVVKGGS-------SVVKGGSSIILGSGQGPVVGSSSVSGSSFSS------TSHTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------LSGSHASF----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RPALSS-----AGR-SG------------------------GFALGHG------------
------------------------------------------------------GAGGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NQ-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-NFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDQ---SN--SKRSLEPIHESYVSSLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKVLYEGEIS-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILNEVR-AQYEDIAVRSKAE
TENVYQCK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
TEINRLIQRIHSE--I---------GNVKKQ-----------------CSSLET----AI
ADAEQQGDCALKDARTKLDQL---------------EGALQQAKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDVEIATYRKL
LESEESR------------MSGECPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGAGFNVG--------
-----------------------------------FGAL--SGYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------ACG-S------ELK-------DPL---AKV-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGAFSGCS--
VVLS-GS-------S---SPSY----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-CA----R
SISFNMASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFSRGR
ASSFGGSMFGSVVLG-PM---C--------P-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LS-VE-LD-PK-IQ-KVC-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQQDL---NN--CKNNLEPIFEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---REIKFFTCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------NSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-VAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
TDAEQRGHCALKDAQAKLDEL---------------EAALLQAKEELARM-------MC-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGTGAG--------
-----------------------------------FGYSGSGTYG-YRP-----------
-----------------SS-------IGGGYGF---------------------------
----LLGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKSRLGSTS-----EI---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRSFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GASGGFGG-----------RGGGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--G-GGG-----------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLSVY-SSG------------------------------ERLGFSGCS--
AVIS-GR-------FSSSRSSF----RA-G------------------------------
----------------------------------VK--GAATFGSRSLFNMG-GG----R
RLALSAA------R-AG------------------------GFAPGQG------------
------------------------------------------------------GTSGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VF----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLESIHEGYISSLRKQ----LEVLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVESLT---DDIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSIINDVR-AQYEDMAVKSKAE
TENLYQDK-------------IQEL-QL-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIHLE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGGLQQSKEDLARM-------LC-
------EHQELLNVK-------------------------------L-ALDMEIATYRKL
LEGEESR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PAGAGFSVG--------
-----------------------------------FGAS--NSYS-YRPM--------G-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EHK-------DSL---TKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRPQR---GFSARSA-----------------------------------
----------------SSALSGG-----------HG---RGSFRSRSLISFE-RC----Q
E-GS-RG-----------------------------------------------------
-----RAWGSRG--R-LA-I---------------------------------R-S-G--
-------K-GS-G-G-PG-L-S-----T-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVK-TR-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QI-LET-KW-HL-LQQ--L---EVSDSPQSLESVFEALLAQLRKQ----LEQLQRER
-----------GTLDA-----ELTTFQKQEEEYKA--KYELEAHRHATVE--NDF-GILK
KEADE----TFL-SKMELEGKLEALR---EFFCFLTRLYEEERS-QL-QTQASDTSVVL-
-SMD-------------------NNCCLDF--------SDIIAEV-RARYEEIASTSKAE
AEALYQN---------K----YQEL-QS-SAQLHGD-NMKETKI-------------Q-I
SQLQHAIQTLQSQ--I---------DSLKGQ-----------------NANLQS----AI
GDTEQRGELALKDAKSKLDEL---------------EGALRMARKDMARL-------LR-
------DYQELMSTK-------------------------------L-SLDVEIAMYRRL
LEGEECRWDGLD----RSGISGECTSQVTIS----------------T--TGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SDIVPGGAGGSQ-GGTCRFRGGKGRFGS-GCSSVV
TGGFGNTLGSG---------------------QGPALGSCSVSGSGFSSSS--SCSHHTI
LKETVESSLKTSTTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSLQLN-IKSGG------------------------------NKGGFSGHS--
AVAL-RK-------AVGSVASH----RVDG------------------------------
-----------------------------------KGA-GASFSSQSLYSLR-GG----Q
CIPLNVAGG--SVR-TG------------------------GYSFWPA------------
-----------------------------------------------------TGYGGGR
ATGFAGRMFGSVALG-PV---CP----SMCP-P-GG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LN-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK--RF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NS--CKKNLEPIFEGYISTLRKK----LEMLSGDR
-----------VRLDS-----ELRSMGDLVEDYKK--RYEVEINRRTTAE--NEF-VVLK
KDADA----AYA-VXXXXXXXXXXXX---XXXXXXXXXXXXEMA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIITEVR-AQYEKIALKSKAE
AEALYQSK-CLITNFLSLGNQIQEL-QL-AAGRHGD-DLRQTK--------------NEM
SELNRLIQRIRCE--T---------GNVRK-----------------QCANLET----AI
SDAEHRGDNTLKDAQAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECW------------MSGENPSSVS-----------ISVISSSS------------
------------------------------------------------------------
-------------------------------------------ASSYHP---------G-
-----------------SS-------ASTALGA---------------------------
----SGIA-------------------------------------------GSSGSTR--
--------SEQTRSKGVQVG-----DPK-------DSQ---GKS------TS--VSALAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGGFSGHS--
AVVL-RK-------VGGSVASY----HAPS------------------------------
-----------------------------------RGA-GAAFGSRSLYSLCRGD----L
CIPLKVAGS--SVR-TG------------------------GYNFRLS------------
-----------------------------------------------------SGYGGGR
PSGFAGSMFGSVVLG-SV---CPSMCPSMCP-P-GG-I-HQ-VV----------V-HK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-MA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQLDL---NN--CRKNLEPILEGYIGNLRKQ----LETLSGDR
-----------LRLDL-----ELRGMRDLVEDYKK--RYEVEINQRTAAE--NDF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDIQFLKCLYDAEVA-QI-QTHTSETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQSK-------------IQEL-QL-AAGRHGD-DLKHTK--------------NEM
SELNRLIQRIRCE--I---------ANVKK-----------------QCANLET----AL
ADAEQRGDSALKDARAKLDEL---------------EAAMHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVSSSSA------------
------------------------------------------------------------
-----------------------------------------SSSG-SHP---------G-
-----------------SP-------ACTDLGA---------------------------
----STTAST-----------------------------------VT----SSSRSTR--
--------SGQTRAKGAQGG-----DPK-------DSQ---DKS------TP--GSGRAR
-KAAR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------PKGGFSGCS--
AVIA-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PI---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISTLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTTAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLRT-K--------------NEI
SELT-LIQRIR----S---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQGKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TGGSSGYG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSSS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYS-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--MSSTTMRSQCS--S----------------------------------RRGFSASS--
ARVPGV----C--RS---GFSSVSVSRSRGSGGL--------------------------
----------------------------------GGVCGGAGFGSRSLYGLG-GS----K
R-ISIGGGSCAXXXXXX-------------XXXXXXXX------XXXX--------XXX-
----XXXXXXXXXXX-XXXXX-X----X-------------------------------X
---XXX-XXXX----------XX----XXXX-X-XX-X-XX-XX----------XX-X-X
X--XXX-XX-XX-XX-XX-XX-XXX-XX-X------------------------------
------X-XXX-XX-XX-XX-XX-XXX-XX-VRF-LE---------------------Q-
QN-KV-LDT-KW-TL-LQEQGT---KT--VRQNLEPLFEQYISNLRR----QLDSILGER
-----------GRLDS-----ELRGMQDMVEDFKN--KYEDEINKRTTAE--NEF-VTLK
KDVDA----AYM-NKVELQAKVDALM---DEINFTRAFYEAELA-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT-------------KYEEL-QL-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------VGSVASH----RGAG------------------------------
-----------------------------------KGA-GAGFGSRSLYSLR-GD----R
CSSLHVAGG--DVR-TG------------------------GYSFCPG------------
-----------------------------------------------------SGYGGGW
APGFAGSMFGSVALG-PV---CP----SMCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PK-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CQKNLEPILEGYISTLRKQ----LETLLGDR
-----------VRLDS-----ELKSMRVLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYM-VKVELQAKVDSLE---KDIKFLKCLYDAEIA-QI-QTHASETSIIL-
-SMD-------------------NNRDLNL--------DSIIAEVR-AQYEKIALKSKAE
AEALYQSK-------------IQEL-QL-AAGRHGD-DLKKTK--------------NEM
SELNRLVQRIRCE--T---------VNVRK-----------------QCANLET----AI
ANAEQKGESALKDARAKLDEL---------------EAALHQGKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISNAG------------
------------------------------------------------------------
--------------------------------------------SYHLG-----------
-----------------SS-------ASTTLGA---------------------------
----SSAA-------------------------------------------GSSGSTW--
--------SEQTRTRGAPGA-----DPK-------DSQ---GKS------IP--VSAPAK
-KDTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYY-PGG------------------------------ERLGFSGCS--
AVIS-GR-------VSSSAASF----RA-G------------------------------
----------------------------------VK--GTAAFGSKSLFSLV-GS----R
RMSISAPAR---------------------------------------------------
-------------------------------------------------------QGTGS
CASRVGTVFGSKGLG-SA---CQ----FMCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-MQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKTLEPIYETYIVNLQKQ----LETQLGDR
-----------VRLDS-----ELRTMQDVVEDYKQ--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYT-NKVELQAKVDSLT---NEIKFFKCLYEGEIA-QM-QSHISDTSIVL-
-SMD-------------------NNRDLDL--------GSTIAEVK-AQYEDIALRSKAE
AEALYQSK-------------XXXX-XX-XXXXXXX-XXXXXX--------------XXX
X-------------------------XXXXXXXXXX---XXXXXXXXXCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHHAKEELARL-------LR-
------EHQELTSVK-------------------------------L-ALDMEIATYRKL
LEGEESR------------MSGEYPNAVS-----------ISVIS---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
TSLLPG------CRPSFSSVS---VSQGGKSF----------------------------
-----------------------------------GGSCVGGFGTRSLHSFG-GS----K
RISISGG------------YRCSRAS---------------GGG------------ASYG
LGLGGM-----G----YRAG---------------------GAFGGYG------------
-------FGG--G--------------MMS-GS-GG-I-QE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQEH-----KT--TRANIEPMFEAYISNLRRQ----LDCLGGER
-----------TRLET-----ELKNMQDVVEDFKN--KYEEEINRRTVAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVDALM---DEINFLRAFYDAELA-QL-QAQISETSVVL-
-SMD-------------------NNRKLDL--------DSIISEV-KAQYEDIANRSRAE
AESWYQT---------K----VRCQ-GQ-VHETVLE-NWD--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKHGAV------------------------------TKGSFSGCS--
AVLS-GG-------S---SSSY----RAGA------------------------------
-----------------------------------KGF-SGGFSSRSFYSPG-GA----R
SIPFNVASG--SGR-VG------------------------GY-----------------
------------------------------------------------------GFGRGW
ASGFAGSMLGNVALG-PS---SP----SLYL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NS--CKKNLEATYEGHISSLQKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDTVEDYKK--RYEEEINKRTTAE--NDF-VVLK
KDVDA----AYM-SKVELQAKVDVLE---REIKFFKYLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------NEI
SELTRLVQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TTGAGAG--------
-----------------------------------FGFGSTGSYG-YRP-----------
-----------------SS-------VSGAYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPL--
--------G-EAKTKLGSAS-----EFK-------DVP---GKT-------L--ALSVPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGAG-------------------------------NRGFSGCS--
AVLS-S--------S---SSSY----RAGG------------------------------
-----------------------------------KGL-GGGFSSRSLYSLR-GA----R
SISFNVAGV--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGALG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPVYEAHISSLQKQ----LDTLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ENVKKQ-----------------CSSLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTP---G-------
---------------------------------------------AVGSGAS--------
-----------------------------------FGFSSTGNYG-FRT-----------
-----------------SS-------VGGGYSI---------------------------
----LSGGCVT-----------------------------------G----GGNCSSR--
--------G-ETKARLGSTS-----EFK-------DVS---GKN-------L--ALGSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSTFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGV-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEINFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------VAAC----QAAG------------------------------
-----------------------------------HRA-GSGFSSRSLYSLG-RN----R
QATFNVAGG--SAR-AA------------------------GHSFGHS------------
-----------------------------------------------------SGYAGTR
ASGFASSMFGSMALG-PT---CP----STGL-P-GG-I-HR-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-VQ-E------------------------------
------R-EQI-RA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CKNSLEPIYEAHIGSLRKH----LDALSGDG
-----------LRLDS-----ELRNMRDVVEDYKK--RYEVEIARRTAAE--NEF-VLLK
KDADA----AYT-AKVELQAKVDSLD---KDIKFLKCLYDAEIA-QL-QTHASDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEDIALKSKAE
AETLYQTE-------------IQEL-QL-AAGCHGD-NLKHTR--------------NEM
SELNRLIQRIRCD--I---------ASVKK-----------------QCSNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALQQAKEELARM-------MR-
------EYQELMSMK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSY------------
------------------------------------------------------------
-----------------------------------------GSYG-YHP-----------
-----------------SS-------MSSDFGA---------------------------
----DNAA-------------------------------------------GSPGTPR--
--------NNQAKKT-RGAR-----DIR-------DSQ---DKS------TA--VGTLAK
-KTT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQF--KSGAA------------------------------TKGGFSGYS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------K----GGFSSRSLFSLG-GT----K
NISFNVASG--SGK-NG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVAVG-PV---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RFEDEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---NEIKFLRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSVIDEVR-AHYEDIALKSKAE
AEALYHTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGDSRSR-GSAS-----DYK-------DTV---GKG-------S--SLSTPS
KKANR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFASKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-GGGFGSRSLYGLG-CA----R
SISLNVAGG--SG-KS--------------------------------------------
-------------------G--------------------------------GYGFGRGR
ASGFAGSIFGSVALG-SA---CP----PVCP-P-GG-I-HQ-VT----------I-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIFEGYIGTLQKQ----LEMQSGDK
-----------VRLDS-----ELRTVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFLRCLFEAEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-THYEDIALKSKAE
TEALYQTK-------------DGES-RL-SFGRWGD-KMSISQ--------------EQK
GNLRLVIC----V--L---------SPVSL-----------------SASNLET----AI
ADAEQRGDSALKDARAKLDGL---------------EAALHQAKDELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------IG-SLGFLVG-----------LAVISST-------------
------------------------------------------------------------
--------------------------------------SGSSGYG-FRP-----------
-----------------GS-------VSGGYVA---------------------------
----NSSSCIS-----------G------------------------------VCSVR--
--------GGEARARGS-TS-----DYK-------DAL---GRG------S---SLGAPS
KKAIR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------M-NKVELQSRADSLM---DEINFLRTLFEAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRSLDL--------NGIIAEV-KAQYEDIAQRSRAE
AESWYQT---------K----YEEL-QI-TAGRHGD-DLRNTKH--------------EI
SEMNRMIQRLRAE--I---------DNVKKQ-----------------CANLQN----AI
AEAEQKGEMALKDARMKLDEL---------------ENALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEGV--GPVN---------ISVV----------------
-------SST----------------------------VSSGYGSGSGSGI---------
---G-----------------------------G--------------------------
------------------G--------------------------------------FGM
G------------------GGSGYSYGSSSSHSL----GG-GL---------SVGGGF--
---------------------------TA---------------------------GSGR
G----SMGGSSSS--I----KYTTT-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFSSRS----------------------------RRVCSTSS--
---------------------------SAGS-GGG-------------------------
---------SRVVGSVCQARGRCGG--------GGYGSHGRGFGSRSLYNLG-GS----K
SISISLVGRSASG--FQQGRGA-------------------GGGFG------------GG
RGFGG-----------GG-----FGGG--------GFGSG-----VYG----GGSFGGAG
--FG-ASNFGLGGFG------------PSC-PM-GG-I-QE-VT----------IN-E-S
L--LEP-LH-LE-VD-PE-IQ-RIK-AQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RSNNLEPVLENYISELQRQ----VDFLNAER
-----------MRQNT-----EVRSMQDVVDDYKN--KYEDEINKRTSSE--NDF-VVLK
KDVDA----AYM-SKVDLQSRTDTLA---REIDFLKYLYTTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RNQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTIQRLQTE--I---------GNVKKQ-----------------NDQIRS----AI
SDAEERGERALQDAQQKLQDM---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEECR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VTVSGAGGGG-GR-----GSGG
-------------------------------------------YSGSS-G--GGGGG-GY
G-------------G---------------------------------------------
---------------GYG------GSSRGGGAR-GGSGG-------------------GY
GGG---SG-GS-YGASRGK-----------------------------------YGG-GG
R----SGGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
KLIRE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------LSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RLALSS-----AGR-SG------------------------GFTLGHG------------
------------------------------------------------------GASGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--SKRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKVLFEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILAEVR-AQYEEIAVKSKAE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKHTK--------------SEI
TEINRLIQRIHSE--I---------GNMKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MAGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGAS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPP---AKT-------S--GSSGTT
KKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSAHSA-----------------------------------
----------------CSAFSGA-----------RG---RTGFSSRSLSSSR-RC----R
G-SS-CG-----------------------------------------------------
-----RAWGAET--R-QG-I---------------------------------R-F-G--
-------Q-GK-G-G-PG-F-S-----Q-CP-P-GG-I-QA-V---------T-VD-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TR-EI-RS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLECIFETCLARLRQQ----LEELQRER
-----------RALDS-----ELKTYQDQEDEYKS--KYDQEAYKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGNLESLK---EHVCFLTRLYEEELG-QL-KTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITRTSKAE
AEAVFQT---------K----YQEL-QE-SAQLQGN-SMKEAQV-------------Q-I
SQLRQAIHRLQSQ--I---------GSLRKQ-----------------NDSLQS----AI
ADAEQQGEMAVRDAQAKLDEL---------------EAALRTAKQDMAQM-------LR-
------DYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISTEHTSQVTVS----------------I--TEGSIVP---
---GRTCGGQ-----------------VVVP-------------------G---------
RIGT----------GQVVMP--------GRECGGHVVM-------PGRGSGGQ-----VT
IPGRGSG----------GQVTVPRGECGGQVTMPG-------------------------
---RGSGGQVTMPGRGSGGQVTIPGRGSGGQVTVPGRGSGGQVTIPGRGSGGQVTIPGRG
SGG-------Q-VTVPGRGS--G-GQVTIPGRGSGGQVTIPGRESGGQVTIPGRESGGQV
TMPGREYGGQVTIPGRESGGQVTMPGRGSGGQVTMPGRGSGGQVTVPGREYGGQVTVPGR
GSGGQVTVPGREYGGQVTVPRGECGGQVTVPGREYGGQVTMPRGECGGQVTMPGREYGGQ
VTMPGRES-GGQVTVPGREYGG-QVTMPRGECGGQVTVPGREYGGQVTMPRGECGGQVTM
PGREYGGQVTVPRRECGGQVTVPGREYGGQVTMPGRESGGQVTVPGREYGGQVTVPRGEC
GGQVTVPGREYGGQVTVPRGECGGQVTVP-----------GREYGGQVTMPRGECGGQVT
VPRGECGGQVTMPGREYGGQVTVPGREYGGQMTMPGRECGGQEVIPRGECGGQVVMPGQE
CGGQAVIPRGDCGSQVVIPREECGGQVSMP-RGECGGQVGTCGHRGWQGSFGSGGCSSIV
TGGFEIPQGSG---------------------YSPTMGSCSVSGSGFSSGS--GSSCRTI
LKKTVESSRKMSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FRHGGGV-------------------G-GFG------------GV
RSFGV-----------GN-----IGAG--------GFGGG-----GFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYISDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEISKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDAQQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSIRGGAEGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------FSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCMG-GG----R
RLALSS-----AGR-SG------------------------GFALGHG------------
------------------------------------------------------GASSGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-CFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKRSLEPIHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVDLQAKVDSLT---NDIKFFKVLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRQLDL--------DSILTEVR-AQYEEIAVKSKTE
TENMYQCK-------------IQEL-QA-TVGQHGD-DLKLTK--------------TEI
TEINRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MNGDYSHAVS-----------ISVISNTNA---G-------
-------------------------------------------PGGSGFNVD--------
-----------------------------------FGSS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DSP---AKT-------S--GSSCST
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAV------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYNLG-GA----R
SISFNVASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRSR
PSGFAGSIFGSVALG-PV---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFYKCLFEAELA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-NQYEDIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELNRLIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------ESALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPS--P--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-GSAS-----DYK-------DTL---GKS-------S--SLSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MTQRSSVTIKSG------------------------------GTQNFSTSS--
ASLLPG----C-------------------------------------------------
-------------------------------------GLRGGFGTRSLQGFG-GS----K
RISINGGYHSSRR-----NFGG----ASCGLGIGGIGY------RA--------------
--------------------------GEAFG------------G---------YGFG---
---GG--MV-P-GA--EG---------IH-E-V--T---VN--Q-----------S-L--
L---TP--L--H-L--T--L--NN--K--F------------------------------
------A-S-F-I--D--KV--C--FL--E--Q--QN-K-VL-E-TK-WS-L--------
----------------LQDQKT-------ARANLEPIFEVYINNLRRQ----LDCLGGDK
--------------------------------RVG--AQPEEINRHTAAE--NEF-VVLK
KDMDA----GYM-NKVELEAKVDALM---DEINFLRAFYKAELA-QL-QAQISKTSVVL-
-SMD-------------------NNHRLDL--------DSVIAEV-KAQYEEIANGSWAE
AESWYQT-------------KYEEL-QW-SAGQHGD-DLRTTRM--------------EI
SELNRAMQRLSSE--I---------DNLKKQ-----------------CTTLQA----TI
ADAEEHGELALKDARNKLAGL---------------EDALQKAKQDMARL-------LR-
------EYQELMNVK-------------------------------L-ALDIKIATYCKL
LEGVGSV---------------------------------------------------NI
------------------------------------------------------------
-----------------------------S----VVSSSGGTGYSG-GSG--F-----CV
GG---------------GG------Y-SGGLCY---------------------------
------------S-------------ATGD---------SSFSSTSGH------------
------------------------------------------------------------
-----SL-S----------------------------------------ST---------
---------------------------------------------------------SSS
MHIISKTS-STKKS---CRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQLN--I----------------------------------KSGG-NKG--
D------------FS---GYSAM-------------------------------------
----------------VP--RK-AVGTAA-SCSAAGKGAGASFGSQSLYSLR-GN----P
HISLNVAGAGVQTGGYSFGL---GSGHAGGRASGFAGS------------------MFG-
----S----------------------VALG-----------------------------
--------------P--V---CR----SMCP-P-RG-I-HQ-VT----------VN-K-S
L--LAP-LN-VE-LD-RE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-NL-LQQLDL---NN--CKNNLEPILEGYISNLQKQ----LEMLTGDS
-----------VRLHS-----ELRITHDLVEDYKK--XXXXXXXXXXXXX--XXX-XXXX
XEADA----AYA-AKVELQAKVDSLD---RDIKFLKCLYDAEIT-QI-QTHVSETSVIL-
-SMD-------------------NNRDLNL--------DSIVTEV-KAQYEDIAQRSKAE
AEALYQS-------------KXXXX-XX-XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX--X---------XXXXXX-----------------CSSLET----AS
VEAEQQGDNALKDARAKLDGL---------------EGTLHQAKEKLAGM-------LR-
------DHQDLIFLK-------------------------------L-SLDMEISIYL--
-------------------MSGE------------------------T--PSSVSISV--
------------------------------------------------------------
-----------------------------------ISSSG-----G-TSYSYQ-----PS
TI-------------------------RADPMVGRA------------------------
---------------SSTSARRGE----------------SIGARAGP------------
--------------HD---------SP------VSTPV----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------GGGR
VRGFVGTVFGSAGLG-PA---CP----PVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQQEL---NS--CRKNLDPIYKGYISKLRKH----LESQSGDR
-----------VRLES-----DLRTMKDLVEEYKK--RYEMEINRRTAAE--NEF-VVLK
KDVDA----HT--HKVEKQAKRDS-T---EEIDLDKSIHEEEIA-QL-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------GSIIDEVH-AHYEEIALKSKTE
AEMLYQSK-------------IQEL-QV-TASRHGD-DLRLTK--------------AEI
MELNKLVQRIRSE--I---------GTVKKQ-----------------CSNLEM----AI
ADAEQRGDTALKDARAKLDRL---------------ECALHQAKEELARM-------LC-
------EYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSCQISCSSQRGGGGKGG----------------------GGGFRGFSSGS--
AIVSGG------SRRSTSSFSC--LSRHGGGR----------------------------
-----------------------------------GGCGARGFGSQSVISLG-GS----K
SISSSVARGGGSFGSSGGFGGRGG-GFGG------------GSSFGGGSGFG--------
-------------------------------------------G---------GRFGGG-
----GG-PGGPGGFG------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-AK-VD-PE-IQ-TIK-SQ-E------------------------------
------R-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---GS--RTINLEPIFQAYINQ----------------
-----------TAQDS-----ELNNMQDLVEDYKK--KFEDEINKRTAAE--NDF-VTLK
KDVDN----GYI-NKVDLQANVEGLA---QETDFLRRVYEVELS-QV-QQTITETSVVL-
-SMD-------------------NNRNLDL--------QGIIAEV-QSQYEDIAKRSKAE
AEGLYHS---------K----YEEL-QI-TAGKHGD-SLRELKT--------------EI
SE-------LQGE--I---------SHVKKQ-----------------CKRVQD----AI
AEAEQRGEHAIKDAQQKLTDL---------------EEALQQARENLARL-------LR-
------DYQELMSTK-------------------------------L-SLDIEIATYRKL
LEGEECR------------SILSF------------------------------------
----------------------------------------------VLK----------Q
GGC---SY------------------------RGGYSSG-NSSYGSGGRRSG------SR
S-GGGSSG-FGGFRGHS------G--SGGGYGSGSG------------------------
--------SGGKP-------SSGGGSGSGGGSRGGSSSGGGFSS-GG-----GSGSGGGF
SSGGGSRGGSSS----------------------------GGGCSSG-----GGSSSGVF
S----SGGGSR---------------GG----FSSGGGFSSGGGSRGGSG------SGGG
VSSSERGGSASGEG---------C---------------------------------GSG
---------VMFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAL------------------------------SKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYNLG-GA----R
SISLNTASG--SGK-TG------------------------GF-----------------
------------------------------------------------------GFGRSR
PSGFAGSIFGSVALG-PV---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------MRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFYKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-IQYEEIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELNRLIQRLRSE--I---------ENAKKQ-----------------ASSLET----AI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPS--P--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRNW-VSAS-----DYK-------DTL---GKG-------S--SLSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKAGAT------------------------------AKGGFSGCS--
AVLS-GG-------ST---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GV----R
SISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PI---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQSKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGESRSR-STTT-----DYK-------DAL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSTITIKSG------------------------------GMRNFSASS--
ASLLPG----C--RP---NFSSFSVSQNR-------------------------------
--------------------------------KSIGGGFRGGFGTRSLHGFV-GS----K
RISISGGYHSSQG-----SFR---------------GY------RA--------------
--------------------------GGAFG------------G---------YGFG---
---GG--MV-H-GA--GG---------IQ-E-V--T---VN--Q-----------S-L--
L---TP--L--H-L--E--I--DP--S--L------------------------------
------Q-H-V-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SLRSAQSQELA-QL-QAQISETSVVL-
-SMD-------------------NNRKLDL--------DSIITEV-KAQYEDIANRSRAE
AESWYQT-------------KYEEL-QR-SAGQHGD-DLRTTRM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CATLQA----AI
ADAEQRGELALKDAKNKLAER---------------EEALQKAKQDMARQ-------LC-
------EYQELMNVK-------------------------------L-ALNIEIATYRKL
LEGEEHR------------KTQ-----------------------------NPANILLFT
------------------------------------------------------------
-----------------------------A----VVSSSGGTGYSA-GSS--L-----CA
GG---------------GG------Y-GGGLCY---------------------------
------------S-------------SAGS---------SGFSSTSGH------------
------------------------------------------------------------
-----SL-S----------------------------------------GT---------
---------------------------------------------------------SSS
MGIISRTS-TTKKS---YRN----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------TMSRQFTCKPGAV------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-NGGFGSRSLYSLG-GA----R
SISLNVASG--SGK-SG------------------------GF-----------------
------------------------------------------------------GFGRNR
PSGFAGSIFGSVALG-PV---CQ----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLDL---NN--CKNNLEPIHEGYISNLRKQ----LETLSGDK
-----------VRLDS-----ELRNVRDVVEDYKK--A----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------SNLET----AI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGS--SG-LRP-----------
-----------------NT-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-SSAS-----DYK-------DTL---GKG-------S--SPSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAL------------------------------SKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYNLG-G------
---------------TG------------------------GF-----------------
------------------------------------------------------GFGRSR
PSGFAGSIFGSVALG-PV---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------MRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFYKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-IQYEEIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELNRLIQRLRSE--I---------ENAKKQ-----------------ASSLET----AI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------LLALDMEIATYRKL
LEGEECR------------MSGEYPS--P--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRNW-VSAS-----DYK-------DTL---GKG-------S--SLSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---CP----SLCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYT-SKVELQAKVDALD---GEIKFFKCLYEGETA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------MAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFR-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYTTCKSGA------------------------------ASRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SITLNMASG--SGK-NG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELSRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEERGDSALKDARAKLDEL---------------ESALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYP------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-GSAS-----DYK-------DTL---AKG-------S--SLSTSS
KKGGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSHPS----CQAQR---GFSVRSA-----------------------------------
----------------CSPRSGG----CG-R---------GSFSSRSFGSFG-GR----R
G-GF-RG-----------------------------------------------------
-----RAWASGG--R-LG-V---------------------------------W-L-G--
-------E-GR-C-G-PG-L-S-----L-CP-P-GG-I-RE-V---------T-ID-H-S
L-L-TP-LK-IE-ID-SQ-FQ-AVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSDSPQGLESFFEAYVAQLKRW----LEQLQREQ
-----------GALDA-----ELKFCQDQEEEYKA--KYEQEAYRHATLE--NDF-VVLK
KDADG----VFL-SKMELEGTLESLQ---GYFCFLKHLYEEELN-QL-QTQASDTSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEIARNSKAE
AKMLYQT---------K----YQEL-QA-SAQLHGD-SMKETKV-------------Q-I
SQLQQASQRLQSQ--I---------ENLKKQ-----------------NADLQA----TI
ADAEQRGDLALKDAQAKLEEL---------------EAALRAAKQDLARM-------LR-
------EYQELMGMK-------------------------------L-ALDVEIATYRRL
LEAEECR------------MSGECTSQVTVS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STIVSGGAGGDL-GGACGLRGGKGSFGS-GCSSIV
TGGSSVNLGSG---------------------QGPVWGPCSVSGSGFSS--GSSSGGHTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFSCRSGYRSG------------------------------GGFSSGS--
AGMVSC------QRRTTSSSM----RRSGG-GGG--------------------------
---------RFSA---------CGGGGGG----GG----SGGFGSRSLVNLG-GS----K
SISISVARGSGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----FGG-------G-GFGG----GGFG-GGGSFGGR----GGYG-GG
--------GYGGGQG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQVDT---ST--RTHNLDPYFENFIALLRRQ----TEQLKNDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVNLQAQVDNLR---QEIDFLTALYQAEVS-QM-QTQISETSVIL-
-SMD-------------------NNRTLDL--------DSIIAEV-KAQYEEIAKKSKDE
AETLYQS---------K----YEEL-QM-TAGKHGD-SVKNSKI--------------EI
SDLNRAIQRLRSE--I---------DNVKKQ-----------------ISNLQQ----SI
SDAEQRGENALKDAKGKLNDM---------------EDALQQAKEDLARL-------LR-
------DYQELLNIK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECP--PSVS---------VSVNTSHT------------
---------------------------------------SISGSGSG-------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------GG---------GGSTSGGRGS--
------GGGSSGGSSGGRGSS-----------------------------------SGAV
K----SSGSSSGV-------KFNSS-TYSR------------------------------
------------------------------------------------------------
--------------------EVR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------TKRGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GP----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
AS---GSMFGNVALG-SV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPILEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIT-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVC-TQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------GANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARL-------LR-
------EYQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVFNSSMA---G-------
---------------------------------------------AAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGSSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAN-----EFK-------DSQ---GKT-------L--ALSSPT
KKAMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------MASTSTTIRSH--SS----------------------------SRRGFNANS--
ARLPGV------SRSGFSSVS---VSRSRGSG-G--------------------------
------------------------L--------GGACG-GAGFGSRSLYGLG-GS----K
RISI--GGGS-CAISG--GYGSRAG-----------------GSYGFGG-------AGS-
-----------G----FGFG-G-------------------GAGIGFGL-------GGGA
--GLAGGFGG--PGF------------PVC-PP-GG-I-QE-VT----------VN-Q-S
L-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------YEDEINKRTAAE--NEF-VTLK
KDVDA----AYM-NKVELQAKADTLT---DEINFLRALYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CASLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------VSVV----------------
-------QST----------------------------VSSGYGGAS--GV---------
---G-----------------------------S--------------------------
------------------G--------------------------------------LGL
G------------------GGSSYSYGSG--LGV----GG-GF---------SSSSGR--
---------------------------AI---------------------------GGGL
S----SVGGGSST--I----KYTTT-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKN----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRTQR---GFSARSA-----------------------------------
----------------CSAFSGA-----------RG---RAGFSSRSLSSSR-RC----R
G-SS-CE-----------------------------------------------------
-----RVWGAEA--R-QG-L---------------------------------R-F-G--
-------R-GS-G-G-PG-L-S-----Q-CP-P-GG-I-QA-V---------T-VN-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLEPIFEACLARLRQQ----LEELQRER
-----------GALDS-----ELKTYQDQEDEYKS--KYDQEAHKHALVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGKLESLR---EYVCFLTRLYEEELG-QL-QTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITQTSKAE
AEAVFQT---------K----YQEL-QA-SAQLQGD-SMKEVRM-------------Q-I
SQLRQTIQKLQSQ--I---------SSLKMQ-----------------NGTLQS----AI
ADAEQHGEMALRDAQAKLDEL---------------ETALRTAKQDMAQM-------LR-
------EYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISKEYTSQVTVS----------------T--AE--------
------------------------------------------------------------
--------------GRVVVP--------GGVGGGQVVI-------PGRIGGGQ-----MI
VPGRIGG----------GQVVIPGRINGGQMVK---------------------------
----------------------------------PGGDCGGQMVIPGRVDGG--------
----------Q-KVIPGRVD--G-GQVVKPGEDCRGQMVKPGGVDGGQMVIPGRVDG---
--------GQMVIPGRVDGGQK-----------VIPGIVDGGQM----------------
-----------------VMPGGIDEGQVIVPGEDCRGQMAMPRGDCRGQN----------
----------------------------------------------------------VI
PGRVDGGQMV-----------MPGGDCRGQIVMSGGDCGGQMVMPGGVDGGQMVMPGGDC
RGQMVIPGGDCRGQMVMPGRDCGGQNFIP-----------GRVDGGQMVIPGGDCRGQMV
MSGGDCGG----------------------Q-----------MVMSGGDCGGQMVTP---
-------------------GGDCRGQMVVP-G---GVGDGTCGLRGWKGSFGSRGCSSIV
TGGFDVPQGSG---------------------CSPSMSSCSVSGSGFSSGS--GSCCRTI
LKKTVESSRKTSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGGGG--------
-------GG-------RGS-----------YG----------------------------
-S---GGGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLF-AGG------------------------------ERLGFSGCS--
AVLS-GR-------FGSSRASF----KA-G------------------------------
----------------------------------VK--GAAPFGSRSLFSLG-GS----R
RQARC-A-G--SER-GG------------------------GFALGHG------------
------------------------------------------------------CVGGGR
PGGFVGTIFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LSP-LN-VE-LD-HE-IQ-KVR-VQ-EREQIKALNNKFASFIDKVIPLKVELDHEIQ
KVRVQER-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CGEKLEPIYEGHISGLRKQ----LETLSGDR
-----------VRLES-----ELRNMRDVVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKIELQAKVDSLT---EAIKFFKYLYEEEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRELDL--------DSIIDEVR-VQYEEITQKSKAE
AECLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SEVNRLIQRLHSE--I---------GNVKKQ-----------------CSNLET----SI
ADTEQRGDCALKDAQVKLHEL---------------EDALQQGKEELARL-------LL-
------EYQDLLNIK-------------------------------L-ELDIEIATYRKL
LESEESR------------MSGEYPNSVS-----------ISVISSINA---G-------
-------------------------------------------TGGAGFNVG--------
-----------------------------------FGAS--SSCS-YKSA--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------NC--VR-----ELK-------DPL---GKT-------P--GSSCVT
KKVSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAAGGFGG-----------RGGGFGGGSSF------GGG
SGFSGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GLGGPG
------GFG------------------PGGYPG--G-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RPINLEPIFQGYIDSLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QEIEFLKVLYDAEIS-QI-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AEALYHS---------K----YEEL-QV-TVGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAAFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRQS-------G-
--------------------SRGG--SGGGGS----------------------------
----ISGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--I-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PGG------------------------------ERLGFSGCS--
AVLS-GR-------IGSSSASF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCPG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLR-PA---CP----AVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-DL-LQQLDL---NN--CRNNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSFT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
VDAEQRGDCALKDARAKLDEL---------------ESALYQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GGSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSRSS----CQARR---GFSARSA-----------------------------------
----------------CSARPGG----RS-GG--------GSFSNKSFSSFG-GC----R
A-GF-RG-----------------------------------------------------
-----RAWGSGG--G-PG-V---------------------------------R-F-G--
-------V-GR-G-G-PG-L-S-----L-CP-P-GG-I-RE-V---------T-IN-H-S
L-L-TP-LK-IE-IE-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-DQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-GL-LQQ--L---GESDSAPALESFFEGYLAQLTWR----LEQLRSER
-----------KAVDA-----ELKSCQDQEEEYKA--KYEEEAHRRATAE--NDF-VVLK
KDVDG----VFL-SKMELEGKLASLR---EYICFLRQLYAEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRGLDF--------SDIIAEV-RARYEEIARSSKAE
AETLYQT---------K----YQEL-QA-SARLHGD-SMKQTKV-------------Q-I
SQLQQTSQRLQSQ--I---------ENLKKQ-----------------NASLQA----TI
TDAEQRGELALKDAQAKLAEL---------------EAALRAAKQDLARL-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRRL
LEGEESR------------MSGGCSSQVSIS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVASGRTGGGL-AGTCGLGGGKGSFGP-SCSSIV
TGGSSVILGSG---------------------QGPAFGSCSVSGSGS----GSSSSCHTI
LKKTVESSLKTSGGG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQITCKSRGRG-G-------------------------GGGFRGFSSGS--
AVVSGG------SRRSGASFSC--ISRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGSF--------GSGGGFGG-----------RGGGFGGGSGFGGG------
SGFGGGGFGGGG----FGG--GRLGG---GGGF-G-------------------GFGGPG
------GFG------------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-ID-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQIDV---RT--RTTNLDPIFQAYIGQLKKY----VDSLSAER
-----------TTQDL-----ELNNMQDLVEEFKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----TYM-TKVELQSKVDVLN---QEVEFMKVLFDAEVS-QM-QSHVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QNQYEEIAQRSKTE
AEALYQS---------K----YEEL-QV-TAGKHGD-SVKEIKM--------------EI
NELNRVIQRLKGE--I---------DHVKKQ-----------------CKNVQD----NI
ADAEQRGEHAIKDAQNKLTDL---------------EEALQQAREDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEEYR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------VSSNVASKAGFGVG-QGSGGRG
SGSG--G---------------------------GFSSG-SSSYGSGGRGS-------G-
--------------------SRSG--GGGGGYGSG-------------------------
--------GSR----GG--SGSGGGYGSGGGSRG--------------------------
------------------GS--G-G-----------GYGSGGGSRG------SS--G---
-------------------GGSKGG-SGSG------GGYGSGGGFK------------SG
GSISDKGGSGSGEGY--------G---------------------------------GSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFACKSGVA------------------------------TNRGFSGCS--
AVLS-GD-------S---SSSY----QAGG------------------------------
-----------------------------------KSL-SRSFGSRSLYSLG-GA----R
SVSFNVASG--SGR-AG------------------------SY-----------------
------------------------------------------------------GFGRSR
ASGFAGSMFGNVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NS--CKNNLEPILEGYISTLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKT--RYEEEVNKRTTAE--NEF-VVLK
KDVDS----AYM-NKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRSLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELLRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGTGLG--------
-----------------------------------FGFSGTGTYG-CRP-----------
-----------------SS-------V--GYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSTS-----EFK-------DLP---GKT-------S--ALSSPV
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLHPY-PGG-------------------------------RLGFSGCS--
TIIS-GR-------VSSSSASF----RA-G------------------------------
----------------------------------VK--ST-AAGSRSLFNLG-GG----R
RLALSRP-----------------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTIFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-VD-PK-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDV---NN--CRKNLEPVYEGYISTLRKQ----LETLSGDR
-----------VRLDS-----ELRTMQDLVEDYKK--RYEVEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIINEVR-AQYEEIALKSKAE
AEALYQSK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELGRM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTG------------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKPG--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPF---TKT-------S--GSSCAT
KKKASR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTYKSGAP------------------------------TKGGFSGCS--
AVLS-GG-------PSS-SSSY----RAGG------------------------------
-----------------------------------KGL-QGGFGSRSLYSLR-GT----R
SISLNVAGG--SGR-SG------------------------GY-----------------
------------------------------------------------------GFARGR
ASGFAGSIFGSVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---SN--CKKNLEPIYEGYINNLQRQ----LEALSGDR
-----------VRLDS-----ELRNMRELVEDFKKSQRYEEEINKRTTAE--NEF-VVLK
KDVDA----AYT-NKVELQAKVESLD---GEIKFLKCLFEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------GSIIDEVR-NQYEETAMKSKTE
AENLYQSK-------------FQEL-QL-AASRHGD-DLKHTK--------------NEI
SELSRLIQRLRSE--I---------ENVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHSAKEELARL-------LR-
------DYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSTMA---G-------
---------------------------------------------NANTGTG--------
-----------------------------------FGLSGASSYG-FRP-----------
-----------------SS-------VSGGYGT---------------------------
----LGGGCVI-----------------------------------G----SGACSPR--
--------G-ESKTQLSSTN-----EYK-------DTL---GKI------PL--ALSSPT
KKMTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGF-SGGFGSRSLYSLG-GT----R
SISLNMASG--SGR-AG------------------------SY-----------------
------------------------------------------------------GFSRGR
ASGFAGSLFGSVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSVRDGVEDYKR--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-VAGQHGD-DLKHIK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALLQAKEELARL-------LR-
------EYQELLSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEY------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------I-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-L-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADE----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QF-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGGL-GSVCGLGGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQMSCRSR-R-GG--GGGR---------------------GFRGFSSGS--
AVVSGG------SRRSTSGFSC--VSRHGGGG----------------------------
-----------------------------------GGYGGGGFGSRSLVGLG-GS----R
SISISVAGAGGSFSSAGGFGGRGG-GFGG------------GLGGGGG-------GFGGG
LGGGF-----G--------G-GRFGGG-------GGFGGGS----GF------GGPGGFG
--GPGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VQ-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---ST--RTTNLDPLFQAYISDLKKT----VDRLSAER
-----------TSQDS-----ELGNMHDLVEDFKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-SKVELQAKVDVLR---EELEFFQVLFAAEIA-QM-QSHITETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-RSQYEDIAQRSKEE
AEALYHS---------K----YEEL-QV-TAGKHGE-SLKDLKM--------------EI
SELNRMIQRLQGD--I---------SHVKKQ-----------------CKSVQD----SI
ADAEQRGENAIKDAKSKLTDL---------------EDALQQAREDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSSDFS--NNVT---------VSVT----------------
-------SST----------------------------FSSNVASRAGIGGG-YG--SGG
RGS---S--SG----------------------GGFSSG-SSSYGSGSRGSS------SR
G-G--G-G-GGGYGSGGGG--SGS------------------------------------
--------------------------GSGGGSRGGSGSG------------------SG-
-------GGFSS---GG--------G---------------------------SGSGGGF
S----SGGGSRGG--SG---------------SGSGGGFSSGGGSRGGSS------SE--
----------KGAG---------K---------------------------------SSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFNCKPGVY------------------------------GKGGFSGCS--
AVLS-GG-------SS---SSY----QARS------------------------------
-----------------------------------KGL-GGNFGSRSLYSLR-GT----R
NISFNVAGG--NG-LN--------------------------------------------
-------------------G--------------------------------TYGLGRGR
PSGFAGSMFGSVALG-PV---CP----SVCP-P-GG-I-HQ-VT----------V-NE-N
L--LAP-LN-VE-LD-PE-IQ-RVR-TQ-E------------------------------
------R-EQM-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---SN--CKNNLEPIYEGHISNLRRQ----LEALSGDR
-----------VRLDS-----ELRNLRDVVEDFKK--RYEEEINRRTATE--NEF-VLLK
KDVDA----AYT-NKVELQAKVEALD---QETKYLKCLFEAEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-SKYEEIAMKSKTD
AENLYQTK-------------FQEL-QL-AAGRHGD-DLKQTK--------------NEI
SELSRLIQRLNSE--I---------ENVKK-----------------QRSNLEI----AI
ADAEQRGDSALKDARAKLEEL---------------ESAMHTSKEELARL-------MR-
------EYQELLGVK-------------------------------L-SLDIEIATYKKL
LESEECR------------MSGEFPSSVS-----------ISVISST-------------
------------------------------------------------------------
--------------------------------------SGSNGYG-YRP-----------
-----------------SS-------VSGGYLA---------------------------
----SSGSCIS-----------G------------------------------VCSTR--
--------ARDGKNQSSVVG-----DYK-------DAL---SKS------S---TLGSSI
RKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---GP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSWQLG-IRSGS------------------------------DKGNFSMLS--
AVVP-RK-------AVGSVVSS----R-AG------------------------------
-----------------------------------QGA-GPGLGSRSLHSLG-GN----R
RISFTVARS--GARGAE------------------------GYSSGTG------------
-----------------------------------------------------SGYGGGR
ASSFPGSKFGSVALG-PT---CS----SVCL-P-GG-I-HH-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VCF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPIYESHISSLRKQ----LEALSGDR
-----------EFLDS-----LTQSL-----------VREVEITRRTAAE--NEF-VLLK
KDADA----AYT-VKVELAAKVDSLD---KDIKFLKCLYDAEIA-QL-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AAGRHGD-DLQHTK--------------SEM
SELNRLIQRIRCD--I---------TNVKK-----------------QCSNLET----AI
ADAEQRGDSALKDAQAKLDEL---------------EGALHQAKEELARM-------MR-
------EYQELMGLK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGENPSAVS-----------IAVISSSSS-----------
------------------------------------------------------------
---------------------------------------SCGTYS-YHP-----------
-----------------SS-------VSAGLGA---------------------------
----GKAAP------------------------------------------------R--
--------SH---PAKTPGG-----DLR-------VSQ---EKS------VT--VSTLAR
-KTPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCSSQRGGGGKGG----------------------GGGFRGFSSGS--
AIVSGG------SRRSTSSFSC--LSRHGGGR----------------------------
-----------------------------------GGCGARGFGSQSVISLG-GS----K
SISSSVARGGGSFGSSGGFGGRGG-GFGG------------GSSFGGGSGFG--------
-------------------------------------------G---------GRFGGG-
----GG-PGGPGGFG------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-AK-VD-PE-IQ-TIK-SQ-E------------------------------
------R-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---GS--RTINLEPIFQAYINQ----------------
-----------TAQDS-----ELNNMQDLVEDYKK--KFEDEINKRTAAE--NDF-VTLK
KDVDN----GYI-NKVDLQANVEGLA---QETDFLRRVYEVELS-QV-QQTITETSVVL-
-SMD-------------------NNRNLDL--------QGIIAEV-QSQYEDIAKRSKAE
AEGLYHS---------K----YEEL-QI-TAGKHGD-SLRELKT--------------EI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKRVQD----AI
AEAEQRGEHAIKDAQQKLTDL---------------EEALQQARENLARL-------LR-
------DYQELMSTK-------------------------------L-SLDIEIATYRKL
LEGEECR------------SILSF------------------------------------
----------------------------------------------TGFGGQG----SGG
RGC---SY------------------------RGGYSSG-NSSYGSGGRRSG------SR
S-GGGSSG-FGGFRGHS------G--SGGGYGSGSG------------------------
--------SGGKP-------SSGGGSGSGGGSRGGSSSGGGFSS-GG-----GSGSGGGF
SSGGGSRGGSSS----------------------------GGGCSSG-----GGSSSGVF
S----SGGGSR---------------GG----FSSGGGFSSGGGSRGGSG------SGGG
VSSSERGGSASGEG---------C---------------------------------GSG
---------VMFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFS--S----------------------------------RSAFSSRS--
RQGH---------RS---GCSAGSGGGAQ-------------------------------
-----------TTGSVCRIRGKCGG-----D---GYGGHARDFSSRSLYDLG-GS----R
SISFNLMGRNAS--GFCQGGT-----------------------------------SGG-
----GRSFGS---GS-YGDGS-S--G-----------------G---------HSFRGAG
---FRGSSFALGGFG--L----------SCP-P-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LK-VD-PE-IH-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RSNNLEPILEKYINELQKQ----VNFLNGEQ
-----------MRQNS-----EVKNIQDVVEDYKS--KYEEEINHRTNTE--NDF-VVLK
KDVDA----AYM-AKVDLQSKVDTLL---GEISFMKYLFEEXXX-XX-XXXXXXXXXXX-
-XXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXXXXXXX
XXXXYQS-------------KXXXX-XX-XXXXXXX-XXXXXXX--------------XX
XXXXXXXXXXXXX--X---------XXXXXX-----------------IDHMHE----AI
SDAEERGEQALQDAKHKLQDM---------------EEALQQSKEQ-----LV-EL-LR-
-----D-YQ-AL-LG--------------VK-LS-----------LD-V---EIATYCQL
LEGEESR------------MFGE------------------------L--QSHVSV----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFALGSR----------------------------HVYNVSSS-
GAF------G--GRSQGSGSVCRIGGRCAGGASGG-------------------------
---------GGFG-------GYS--------------RLRGSYTSQSLYNLS-GH----R
SLSSSLVGDGTSG-FWQSRG---------------------GRGFGGGA-----------
----------------------------GG----RGFGSRS--------------L----
----GGSGFGLGGFG------------PSC-PP-GG-I-RE-VT----------IN-Q-S
L--LQP-LG-VE-VD-PE-FQ-KVK-SE-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-YL-LQQVRT---SA--RRNNLEPILESYIAELRRQ----LDGLNGDR
-----------MRQDL-----EIRNMQDLVEDYKN--KYEEEIHKRTDAE--NDF-VILK
KDVDA----AYM-SRVDLQSRVDTMI---KETDFLKFLYEAELS-QM-QTTTSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIREV-QEQYELIFQKSKSE
TEARYQD---------K----YQEL-QI-TAGRHDD-DLKNTKI--------------EI
SELNRTIQRLQSE--I---------GNVKKQ-----------------IGQVNS----LI
LDAEERGEQALQDAQQKLQDM---------------EEALQQSKENMTRL-------LR-
------DYQELLSTK-------------------------------L-SLDVEIATYKKL
LEGEEYR------------MSGEFQ--NPVS---------ICLSLSLS-------LS---
--LSL--SLS----------------------------LSLSLSFSGSYGGGRRGGGGAG
SRGGGGVYG----------------------------ESSSGGYGESSRSRK--------
--------------------------------------SGVNSRVQIIRTSTNTSRRHVI
E-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------MASTSTTIRSH--SS----------------------------SRRGFSASS--
ARLPGV------SRSGFSSVS---VSRSRGSG-G--------------------------
------------------------L--------GGACG-GAGFGSRSLYGLG-GS----K
RISI--GGGS-CAISG--GYGSRAG-----------------GSYGFGG-------AGS-
-----------G----FDFG-G-------------------GSGIGFGL-------GGGA
--GLAG-----------------------------G-I-QE-VT----------VN-Q-S
L--LTP-LN-LQ-ID-PA-IQ-RVR-AE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VSQ-CH---------------------A-
LH-RA-LQG---------------------------------------------------
---------------------------------PQ--TRRDEINKRTAAE--NEF-VTLK
KDVDA----AYM-NKVELQAKADTLT---DEINFLRALYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------ISVV----------------
-------QST----------------------------VSSGYGGAS--GV---------
---S-----------------------------S--------------------------
------------------G--------------------------------------LGL
G------------------GGSSYSYGSG--LGV----GG-GF---------SSSSGR--
---------------------------AI---------------------------GGGL
S----SVGGGSST--I----KYTTS-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGLG
------GFG------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
STSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRGG--G-GGG-----------------------------
---SVSGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGD-SSSG------GRYSSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSN
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISYQSRGRG--GG-----------------------GGGFRGFSSGS--
AVVPGR------SRLSGTSFSC--LSRHGGGGGG--------------------------
------------------------F--------GGGGFGGGGFSSRSLVNLG-GS----R
STSISVAGGGGSF--------GSYGGFGG-----------RGGGFGGGLGV---------
--------GGGS----FGG--GRFGGGGGFGGL-G----------------------GPG
------GFGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINV---GT--RTTNLEPLFQGYISQLQSH----LDKLYSER
-----------MLQES-----ELNNMQDLVEDFKK--KYEDEVNKRTAAE--NEF-VTLK
KDVDH----AYT-NKVELQAKVDLLR---QDVEFTKMLFDAVSR-LLLNGPLLPTLPLK-
-SMD-------------------NNRSLDL--------DSIITEV-RAQYEEIAQRSKAE
AEAVYHS---------K----YEEL-RI-TAGKHGD-SLKEVKM--------------EI
SELNRMIQRLQGE--I---------AQVKKQ-----------------CKNVQD----SI
ADAEQRGENALKDAQSKLNDL---------------EEALQKAREDLARL-------LR-
------DYQDLMNTK-------------------------------L-SLDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SSS----------------------------ISSGVASRAGFGGY--GSGGRG
SSY-------G----------------------GGFSSG-SRSYSSGGRRS-------G-
--------------------SRSG--GGG-------------------------------
------------------------SYGSGGGSRG--------------------------
------------------GSSSG-GGYSSG-----GKHSSG-------------------
-------------------GGARGG-SSSG-----GGGYG--------------------
---SERGGSGSCEG---------G---------------------------------SSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MGRQLN-INSRG------------------------------DKGNFSVHS--
AVVP-RK-------GTGGVTSY----HATG------------------------------
-----------------------------------QRA-GAGFSSRSLYSLG-GN----W
HIPSNVADS--AIW-AG------------------------GHSFEHG------------
-----------------------------------------------------TEYGGSK
ARGFAGSMFGSVAVG-CG---CL----SVCP-P-KG-I-HQ-VT----------V-NK-N
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KT-LN-DK-FA-SFI-DK-VCF-LE---------------------Q-
QN-QV-LHT-KW-EL-LQQLDL---NN--CRKNLKPFYEGHISSLRKQ----LETLSGDR
-----------MRLES-----ELRRMNNVVEDYKK--KYEVEINRRTEAE--NEF-VVLK
KDTDA----AYT-VKVELQAKVDSLD---KDIKFLKYLYDAEIT-QL-QTHASEASVIL-
-SMD-------------------NNRDLDL--------NSIITEVR-NHYEDIARKSKTE
AETLCQIK-------------IQEL-QL-AAGQHGD-DLKHTR--------------NKM
SELNRLIQKIRCD--I---------ISVKR-----------------QCSNLET----AI
ADAEQQGDSALKDARAKLGEL---------------EGALYQGKDKLAQM-------IR-
------EYQELRSLK-------------------------------M-ALDIEISTYRVM
LEEEEFR------------MSGENPSSFCHLWLIPTSLSFSSIISSN-------------
------------------------------------------------------------
------------------------------------------GYG-YHP-----------
-----------------SS-------VSTDLRV---------------------------
----SSAT-------------------------------------------INAGHLR--
--------TGQTETQGAKQE-----TSG-------TLQ---TRM------AQ--SAPQPR
RLPNKATSPLTSA-----------------------------------------------
------------PGSRD----------------------------------------VLA
------------T---S---Q---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--KYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DDIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKGE
AETLYQIK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKMDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLSLY-SGG------------------------------ERPGFSGSS--
AVVS-GR-------LSSSSTSF----RAGV------------------------------
----------------------------------KG--A-AAFGSRSLFCVG-GG----R
RLALSAA----AAG----------------------------------------------
-----------------------------------------------------AGRSGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NI--SRRNLEPIYEGRISTMQKQ----LEMLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEVEINKRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDAMT---DELKYLKRLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRDLDL--------DSIIDDIR-VQYEDIAQRSKAE
AEALYQTK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SELSRLIQRIRSE--I---------GNVKKQ-----------------CGNLET----SM
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EHQELMSVK-------------------------------L-ALDMEIATYRKL
LEGEESR------------MSGEYPNSVS-----------ISVVSSTSA---G-------
-------------------------------------------A-GAGFGVG--------
-----------------------------------FGTS--STYS-YKPV--------A-
-----------------TD-------IKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DSL---AKT-------S--GGPGVT
KKAPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGI-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNR-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRSVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSS---G----------GS-----------------------------------YAGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------FSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCVG-GG----R
RLALSS-----GGR-SG------------------------GFTLGHG------------
------------------------------------------------------GASGGR
PGGFVGTVFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VV----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDQ---NN--SRRSLEPVHESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSMT---DDIKFFKVLFEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILAEVR-AQYEEIAVKSKAE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKLTK--------------SEI
TEINRLIQRIHSE--I---------GNMKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGVLQQSKEELARM-------LR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MAGEYPSSVS-----------ISVVSSTNA---G-------
-------------------------------------------PGGAGFSVG--------
-----------------------------------FGAS--SNYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPP---AKT-------S--ASSCVS
KKASRQTGEVSRA-----------------------------------------------
------------DGCAT----------------------------------------HSP
------------VLFPPVPSQVRKCFLHH-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAV------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSQSLYSLG-GA----W
SMPFNVASG--PGR-AV------------------------GY-----------------
------------------------------------------------------GFSRGR
ASGFAGSMFGNVTLG-PS---SP----SMYL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-IE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLDL---NN--CRKNLESIYEGHISGLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDMVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKTE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------SEI
SELTRLVQRLRSE--I---------ESVKKQ-----------------CSSLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGGVAG--------
-----------------------------------FGFGGTNTYG-YRP-----------
-----------------SS-------VSGAYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPC--
--------G-EAKTRLGSAS-----EFK-------DIQ---GKT-------S--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSFSP----CWTQR---GFSARS------------------------------------
----------------CSARSGS----RG-M----------GGSSRSLSSFQ-GR----R
G-AS-SG-----------------------------------------------------
-----RTWGSEK--G-LG-M---------------------------------R-F-A--
-------E-GR-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-S
L-L-TP-LK-IE-ID-PQ-FQ-IER-TQ-E------------------------------
------TR-EI-RI-LN-DQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQR--Q---GVSSRPQGLESFFEDYVACLRKQ----LELLQRER
-----------GALDA-----ELKTCQDQEEEYKA--KYEKEAHTRATVE--NDF-VIIK
KXXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXELS-QL-QTQVSDASVVL-
-SMD-------------------NNRCLDL--------SDIVAEV-HARYEEIAQTSKAE
AEALYQT---------K----YQEL-QA-SAQLHGH-STGETKA-------------Q-I
SQLHQAIQRLQSQ--I---------GNLKKH-----------------DVQLLQ----EV
ADQAQV-----------KDEA---------------EAALKLVGENRSQA-------LS-
------EYQXXXXXX-------------------------------X-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXSSIV----------------T--GGSSVIL---
---GSKQ----------------------DPG------------------W---------
GTCS----------ASSSGS--------GSSCHTIVKK---------TVES---------
------------------T-------LKTSITY---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSITIK--SG----------------------------GSRNFSASS--
ANLLSG------CRPSFSSIS---MVQSGKSF----------------------------
-----------------------------------GGGFGGGFGTRSLHSLG-GN----K
RISISSG------------YRSNRTS---------------FGG------------AGYG
LGLGGI-----G----CRVG---------------------GVGSGYG------------
-------FGG--G--------------MMS-GA-GG-I-HE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQEH-----KA--TRANLEPMFEGYINNLRRQ----LDSLGGER
-----------SRLEV-----ELKSMQEVVEDFKN--KYEEEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVEALM---DEINFLRSFYEAELA-QL-HAQISETSVVL-
-SMD-------------------NNRKLDL--------DSIISEV-KAQYEDIANRSRAE
AESWYQI---------K----YEEL-QR-SAGRHGE-DLRSTRM--------------EI
SELNRVIQRLRSE--I---------ENVKKQ-----------------CATLQA----AI
ADAEQRGELALKDAKHKLAEL---------------EEALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LTGEGV--GPVN---------ISVV----------------
-------SSS----------------------------GGSGYSGGGGLCMTGGG-----
-----------------------------------YGFG------SS-------------
-----------GFSSS--------------------------------------------
---------------------------------------GGSF---------SSTSGR--
------------------------------------------------------------
-----GMSGTSSS--V----RIISK-TSSSK-----------------------------
------------------------------------------------------------
----------------SYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CTAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--SIR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEMEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEMA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASQHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSK---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------VGADLGA---------------------------
----STMA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MELEGKLEALK---EFFCFLTQLYEEERN-QL-QTQGSDRSVVL-
-SMD-------------------NSRCLDF--------SDIIAEV-RARYEEIAWTSKAE
AEALFQN---------K----YKEL-QS-SAQLHGH-SMKETKI-------------Q-I
SQLQHVIQELQSQ--I---------SSLKGQ-----------------NANLQS----AI
SDAEQRGELTLKDAKSKLDEV---------------EDALRTAKQDMARL-------LR-
------DYQELMSTK-------------------------------L-SLDVEIAMYRRL
LEGEECR------------ISGECTSQVTIS----------------T--MGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STIVPGGAGGNQ-GGTCEFRGGKGSFGS-SCSSVV
TGGFGNTLGSG---------------------QGPTLGSCSVSGSGFSSGS--SSSHHTI
LKETVESSLKTSIKY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRQSVCRSFGG---G--------------------------SRRGFSSCS--
AIGGGFGG-GSRSRSSYSSYS---VSR---------------------------------
------------------------G--------FGGGGRCGGFGSRSLHSMG-GS----A
RMSMGGCY-----GGRMGGFGGSY-G--------------GLGSFGGGMGGGG--GGMCG
FGGMGGG-GMGG----GGGM-GGFGGGMGGF-------GGGMG---GGG---MGGFGGPG
---FGMGGP---GRG------------GP------G-I-QP-VQ----------ID-T-T
L--LRP-VH-VE-ID-PQ-IQ-QVK-NQ-E------------------------------
------K-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LST-KW-EL-LQQQGP---SG--PRKNLDVIFENYIQNLRRQ----LESILAQR
-----------GQLES-----ELQNMQQYVEDYKS--KYEEEINRRTTAE--NEF-VVLK
KDVDS----AYM-TKVELEARVGALT---DEINFLRCIYEEELS-QM-QTISRDLSVVV-
-SMD-------------------NNRHLDL--------DSIIEEV-RRQYEQIAQSSRAE
AEAWYQS---------Q----YEQL-QS-TAGRHGD-NLRNTKI--------------EI
QELTRNIQRLRAE--I---------ENVKKQ-----------------NQQLQA----AI
AEAEERGEMALKDARLKLEEL---------------ESALQKDKEELARL-------LK-
------EYQELLNVK-------------------------------I-ALDVEIAMYRKL
LEGEENR------------LCNDSM--SNVN---------VSVV----------------
-------GRT----------------------------TVSGGRGGMG-GGFGGSGMGGG
F-------------------------------------------------GG------GS
C-GMGGGF-GG-------------------------------------------------
---------GSGMGGGMGGGGI-------------CGG-------GSSFGGGSMGGSCGM
GGAM--------Y----------GGGFSSG----SGRM--------------CGSGG---
--------GSSSV--RR----CVTT-TSVKSSGVRF------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRPLHLR-PAG------------------------------ERPAFSGCS--
AVLA-GR-------GSASSVSL----WA-G------------------------------
----------------------------------AK--GTAAFGSRSLLSPG-GG----R
RLALAPV----AGR-RG------------------------ASTLGHC------------
-----------------------------------------------------SGSGGGR
LGGFVGTVFGSAGLG-PV---CP----SVCP-P-GG-I-PQ-VT----------V-NR-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETQTGDR
-----------VRLDS-----ELRSMQDLVEDYKKRHRYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QM-QSHISDMSVIL-
-SMD-------------------NYRDLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGRHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARL-------LR-
------EYQELLSTK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEHPSSVS-----------ISVISNTGA---G-------
-------------------------------------------AGGAGFSVG--------
-----------------------------------FGAS--SSFS-FKPA--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------GCG-S------EFK-------DPG---PKG-------S--GGSCAA
RKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GTGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALNSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------SKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GT----R
SISLNVASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRGR
ASGFAGSIFGSVALG-PM---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGHISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSME---QDIKFSKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELNRFIQRLRSE--I---------DNAKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYP---------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-SSAN-----DYK-------DTL---GKG-------S--NLSSPS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSMS----------------------------RRVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYARGRRGS--------GGYGIHGRGFGSRSLYNLG-GS----R
SISINLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RGFGV-----------GS-----TGAG--------GFGGG-----GFG----GGGFGGAG
--FG-TSNFGLGGFG------------PYC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRRQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDAWQKLQEL---------------EEALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSVSGGAGGGGSY-----GSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---GG-G----GGGGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLNHY-PSG------------------------------ERLGFSGCS--
AILS-GR-------LSASSTSF----RA-T------------------------------
----------------------------------AK--GSAAFGSRSLFCLG-GG----R
RLALSAS----AGR----------------------------------------------
--------------------------------------------------------S-GR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---DS--CGKNLEPILEGHITNLRKQ----LEALSGDR
-----------VRLDS-----ELRNVRDVVEDHKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DGIKFYKCLYEGEIT-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AENLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------TEI
SELSRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQQGDCALKDARAKLDEL---------------EGALYQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AAGAGFSVG--------
-----------------------------------FGTS--SAYS-YKPA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SSG-S------EFK-------DPL---AKT-------S--GSSSAT
KKAFR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSCKSGTV------------------------------AKGGFSGCS--
AVLS-GG-------KSS----Y----WIGG------------------------------
----------------------------------KGLS-GGGFGSRSLYNLG-TT----R
NISFNMASG--SG-RLC------------------------GYGFG--------------
---------------------------------------------------------QGR
ASGFAGSMFGSVALG-PV---CP----TVGS-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PX-XX-XXX-XX-X------------------------------
------X-XXX-XX-XX-XX-XX-XXX-XX-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL----N--CRNYLEPILEGFVGNLRKQ----LEALSGDR
-----------VRLDS-----ELRSMRDVVEDNKKXXXXXXXX--XXXXX--XXX-XXXX
XDVDA----AYM-NKVELQAKVDTLD---GEIKFFKCLYEAEIA-QL-QSHISDTSVIL-
-SMD-------------------NNRSLNL--------DSIIAEVR-SQYEDIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
AELTRVIQRLRSE--I---------ESVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLEEL---------------EAALQQAKEELARM-------LR-
------EYQELTSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNAVS-----------ISVISSSTA---G-------
---------------------------------------------TTGAGAN--------
-----------------------------------FGFSSTGTYG-YRH-----------
-----------------SS-------VGGGYSM---------------------------
----LSGGCVT-----------------------------------G----SGNCSP---
--------HGESRMRLGSAS-----EFK-------DAL---GKT------SA--LS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSIH---------------------------------------------TG--
FQSSKG----S--RR---GYSSCSAIGGGGGGG--RHT----------------------
----------YSC---------------R-GFGGGGGGMRGQYGSRSLHNYG-GG----T
RISYGRGYGGGMYGGYGGGYGGGAGGMGGGFGSGMSGG------YGGGG-------MGGY
GGSGMGGYGGGGMGG-FGGGG-M---GGGFG------------P---------GGIGGGF
GPGGMGGGFGGGGFG-PG----G----LAGG-P-GG-I-GS-VQ----------ID-P-S
L--LRP-VN-VE-ID-PQ-IQ-QVK-NQ-E------------------------------
------K-EQI-KL-LN-NQ-FA-NFI-DK-VRF-LE---------------------Q-
QN-KV-LQT-KW-QI-LQQQTQ---GRG-PMQNLDGEYQLFLNGLRNQ----IDQIRSQK
-----------QQLMS-----ELQNMQQVVEDSKN--KYEQEINQRTTSE--NEF-VVLK
KDVDS----AYM-TKVDLDAKVGGIV---EQINFFRRIFDIELS-QI-PIGGKDTSVVV-
-NMD-------------------DSRDLNL--------EGMIDEV-RAQYEEVARSSRAE
AETWYRS-------------QYEAL-QN-AAGRHGE-NLQNTRQ--------------EI
QELTRNIQRLRTE--I---------EHAKKQ-----------------AAQMQS----AI
AEAEERGEMALRDAKQKLDEL---------------EGSLTKDKEVLARL-------LK-
------EYQDLLNVK-------------------------------L-ALDMEIAMYRKL
LEGEESR------------ISGL------------------------G--SQV-------
------------------------------------------------------------
-----------------------------------HVSVRGSSYGG-GIGGGG-----LG
GLGGGLG----------GG------MGGGGLGMGGGLG----------------------
---GGSFGGSGMGGSI-GGGGMGGGMSGGY---------GSVSGGYGG---GSIG-----
-------------YGGGSGG--Y-GGI------ISS-----GG-----------SGGS--
-----SYGG---------------------------GGYSR------GSG----------
---------------------------------------------------------SGS
STIIRRTT-TSSSS---VKGGG-Y------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSRSAFSSRS----------------------------KRVYSGGS--
---------------------------SAGS-GGG-------------------------
---------SRAVRSVCQARGRCSSGGG-----GGYGSHARGFTSRSLYNLG-GS----K
SISISLVGRSASG--FCQGGGA-------------------GGGFG------------G-
RSF---------------------GGG--------GFGGRGFGGGGYG----GGGLGGAG
--FR-GGNLGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-MQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--QTNNLEPIFESYIIKLQRQ----VDFLRAEQ
-----------MRQSS-----EIRSMQDVVDDYKN--KYEEEINRRTSSE--NDF-VVLK
KDVDS----AYL-SKVDLQSKADTLL---EEVDFLKYLFQSELS-QM-QTNITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RIQYEEIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-ELQTSRM--------------EI
SELNLTIQRLQAE--I---------GNVKKQ-----------------IEQMHT----II
SDAEERGQQALQDAQQKLQDL---------------EAALQQSKEELARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------ISVQ----------------
-------SSQ----------------------------LTIGGGARGSGGY-----SGGG
-------------------------------------------GYAG---G-GGYAGGSS
S-------------G---------------------------------------------
--------------GYGGGGPRGGP-----------------------------------
------------------------------------------------------------
--------VASRM-------QIIQT-STS-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--SVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDLKFLKCLYDAEIS-QI-QTHASETSVIL-
-SMD-------------------NTRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPTPCPLRCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKQVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFS--S----------------------------------RSAFSSSS--
RRVC---------SA---GSSAGSGAGGR-------------------------------
-----------ALGSVCFARRCCGS-----G---GHEGYGRGVSSRSLYNLG-GS----K
SIFLNLVVGSAS--GFHQAGGI-----------------------GGG--------CGG-
----GRSFGG---GG-FGGGG-S--GGSGYG------------G---------GVFGSAG
---FGGSGFGLGGFG--P----------SCP-P-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-TK-E------------------------------
------W-EQV-MA-LN-NK-FA-SFI-DK-VRL-LE---------------------Q-
QN-QV-LKM-KW-EL-LQQVNV---SSG-KHSNLEPIFESYISNLSRE----VDRLKAEQ
-----------MRQHS-----EVRSMQDSVEDYKN--KYEEEINRRTNAE--NDF-VVLK
KGMDS----AYS-GQVDLQPKVDILF---GEIKFLKYLYKTELS-QV-QTHISDTNIIL-
-SMD-------------------NNRFLDL--------DSIIDAV-QTQYELISQRSKDE
AEMLYQT-------------KYQEL-EI-TAGRHGD-DLSIKT---------------DM
SELQHV-ISLRAE--I---------DSVKKQ-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXX-------X-XX-XX-
X---XX-XX-XX-XX--------------XX-XX-----------XX-X---XXXXXXXX
XXXXXXX------------MSGD------------------------L--QSQVSISV--
------------------------------------------------------------
-----------------------------------QRSQV-SAAGGGGGGGSG-----PG
GYGGG-G-----------G------S-GSGSGGGGSQG----------------------
---GSRG--T-------SSGTSY------------------SY-GASS------------
--------------E------------------SSHQY---GR-----------WS----
-------------------------------------G---------SGGG---------
---------------------------------------------------------SSR
VQIIQTST-NSTH-RHVVE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSACSA-----------------------------------
----------------CSARSGG-----------RG---RVNFSSRSLSSFG-GC----Q
G-GS-RG-----------------------------------------------------
-----RAWGSRG--R-LG-V---------------------------------R-Y-G--
-------E-GI-G-G-PG-L-S-----P-CP-P-GG-I-QE-V---------A-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVQ-TQ-Q------------------------------
------TQ-QI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-DL-LQQ--Q---ELSDSPQALRSFFEACLFQLRKQ----LEQLQGER
-----------VSLDA-----ELKSCQYQQEEYKA--KYEREAHRCATLE--KDF-VVLK
KDVDG----VLS-SKMELEGKVEALK---EYICFLRRLYEEELG-QL-QTQASDMSVVL-
-SME-------------------NNRHLDF--------RDLITEV-CARYEEIAGTSKAE
AEMLYQT---------K---VYREL-QV-SAQLHGD-RMKGTKV-------------Q-I
TQLQQAIQKLQSQ--T---------ENLKKQ-----------------NAKLQA----AI
AHAEQRGELALKDAQTKLAEL---------------EAALRTAKQDVARL-------LS-
------EYQELMSSK-------------------------------L-SLDVEIATYRRL
LEGEESR------------TSGEYTGQVTIS----------------V--GQG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STIVSGGADGGL-VGTCGLGGGNGSFGS-SRSSIV
---------------------TGDSNVILGSGQGPVLGSCSVSGSGSSS------TCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSTRS--
---------------------------SSGF-GGG-------------------------
---------RQILVSVGQ--SRRCGGDY-----------GGGFSSRSLYSLG-GS----K
SIFGGLVGRSASG--FCQSRGA-------------------GGGFG------------GG
----F------------GGG-RSFGGG--------GFGGGYGGGGRFG-----GGFGG-G
--FG-TSNFGLGGFG------------PSY-PP-GG-I-HE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-KIK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPIFEEFINQLQRQ----VDVLTNEQ
-----------LRQNS-----EIRSMQDIVEDYKN--KYEDEINKRTNSE--NDF-VVLK
KDVDA----AFM-AKSDLQSRVDTLY---GEINFLKYLFDTELS-QI-QTHVSDTNVIL-
-SMD-------------------NNRSLDL--------DSIINAV-RTQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNAQRLQAE--I---------ANIKKQ-----------------IEQMHG----SI
SDAEERGERALQDAKQKLQET---------------EEALQQMKEDLARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYREL
LEGEESR------------MSGALQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTIGGGGGSGGYG-----GGSS
-------------------------------------------RGGGG------------
------------------------------------------------------------
----------------GGGSSRGGGGGT--GSRGGGGS----------------------
------GGGGS-YGSS-SRS--------------SSKYSG--------------------
------GGSSSRT-------QILQT-STH-------------------------------
---------------------------------------------------------TSR
RHVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
---------------------------------------------------SGAAAKG--
G------------FS---GCSAG-------------------------------------
----------------L------SGGSSS-SYRAMHKGLGGGFGSRSLYSLG-GA----R
ITSFNMASGSGREGVYGFS---------RGRASGFAGS------------------MFG-
--------------------------SAALG-----------------------------
-------------P---V---CP----TVCP-P-GG-I-HQ-VT----------IN-K-S
L--LAP-LN-VE-LD-PK-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-----------XXXXX-----XXXXXXXXXXXYEE--EI----NKRTAAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---REIKFFKCLYXXXXX-XX-XXXXXXXXXXX-
-XXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXXXXXXX
XXXXXXX-------------XFQEL-QL-AAGRHGD-DLKYTKN--------------EI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQGKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MCGX------------------------X--XXXXXXXV--
------------------------------------------------------------
-----------------------------------ISSST-----A-GTAGA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MPLSP----CRAQR---GFSTRSA-----------------------------------
----------------CSAHSRG----CS-SV---------GFSSRSLNSFG-GC----L
G-GS-RR-----------------------------------------------------
-----STWGSGA--R-LG-V---------------------------------R-F-G--
-------E-QS-G-G-PG-L-S-----L-YP-P-GG-I-QK-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGRPQGLEPVFEACLAQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYQEEAHRRATLE--NDF-VVLK
KDVDG----VFL-STMELEGKLETLR---EYICFLKRLYEEELA-QL-QTQDSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-TAQLHGN-SIQETKV-------------Q-V
SQLHQEIQRLQNQ--I---------ENLKKQ-----------------NASLQG----AI
ADAEQRGELALKDAQAKVDEL---------------EASLRMAKKNLAQL-------LR-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LESEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVVSGGVGGGL-GGTCGLGGSKGSSGS-RCTSIV
TGGSSVLLGSG---------------------TDPVLGSCSAAGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFT--C----------------------------------KSGAAAKG--
G------------FS---GCSAV-------------------------------------
----------------L------SGGSSS-SYRVGGKGLSGGFGSRSLYNLG-GV----R
SITLNLASGSGKSGGYGFG---------RGRASGFAGS------------------MFG-
--------------------------SVALG-----------------------------
-------------P---V---CP----TVCP-P-GG-I-HQ-VT----------VN-E-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-D K-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-----------XXXXX-----XXXXXXXXXXX YEE--EI----NRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEA-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FRHGGGV-------------------G-GFG------------GV
RSFGV-----------GN-----IGAG--------GFGGG-----GFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYISDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEISKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDAQQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSIRGGAEGGGSY-----VSGG
-------------------------------------------YGGG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YGGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLHLY-QGG------------------------------ERLAFSGCS--
AVIS-GR-------VSSSSASF----RP-G------------------------------
----------------------------------VK--GTATFGSRSLFSPG-SC----R
RLALSTA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGLVGTVFGSTGLG-PA---CP----SVCL-P-SS-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-I--KVR-SL-E------------------------------
------R-EHI-NV-LN-NN-FA-SII-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNHLEHVFEGYTSNLRKQ----LEALSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKAELQAKVDALT---EEIKFFKRLYEGEIA-QI-QSHISDTSVVL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SDLNRLIQRLRSE--I---------GNVKKQ-----------------CSNLEM----AI
ADAEQRGNCALKDARAKLDEL---------------EAALHQSKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTSP---G-------
-------------------------------------------AGGPGFSVG--------
-----------------------------------FGTS--TGYS-YKAS--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------ALP---AKT-------S--GGSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSRS----------------------------RRAYSNRS--
---------------------------ASGF-GGG-------------------------
---------SRTVGSVCHARGRYGGGGY-----------GAAFGSRSLYNLG-GS----K
SIFGSLVGRSASG--FCQSRGA-------------------GGGFG------------AG
RS---------------FVG-GGFG-------------GGGLGGGRFG-----SGYGGRG
--FG-PSNFGLGGFG------------PSY-PP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KF-LN-NK-FA-AFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPLFEAYISDLRRE----VDLLNTEQ
-----------MRQNS-----EIRSIQDVVEDYKS--KYEDEINKRTNAE--NDF-VVTK
KDVDA----AFM-GKSDLQSKVDTLQ---GDINFLKYLFDKELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------ESIIDAV-RFQYDLIAQKSKEE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNTKM--------------EI
SELNRNTQRLQAE--I---------ASVKKQ-----------------VGWMHG----SI
SDAEERGERALQDAKQKLQDL---------------DEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYCKL
LEGEESR------------MSGELQNHV--S---------ISVQ----------------
-------SSQ----------------------------VTVGGGGGGSGG--------YS
-------------------------------------------GGGGG------YGGGSG
------------------------------------------------------------
---------------GGSGGYSG-----------GGGG----------------------
------GGGGS-YGGSSSKS--------------SSKYGG--------------------
R----SGGGSSRT-------HFVRT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VRF-LE---------------------Q-
QN-KV-LET-KW-NL-LQQLDL---NN--CKNNLEPILEGYISNLQKQ----LETLSGDK
-----------VRLDS-----DLRNVRDAVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYF-NKVELQAKVDSMN---QEIQFLRSLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEIR-AHYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----SI
ADAEQRGDNALKDARAKLVEL---------------EGALYQAKEELAGM-------LR-
------EYQELMNLK-------------------------------L-ALDMEIAMYRKM
LEGEECR------------MSGEYSSP----------------VSI--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYG-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFS--S----------------------------------RSGYRSGG--
G--F---------SS---GSA-GIVSFQR-------------------------------
-----------RTTSSCSRRSGGGGGRYS-GGGYSGRGAGGGFGSQSLVNLG-GC----K
SISMSVARGGTSGGGYRSGGYGGG-SFGGGFGSGGGFG------SGGG--------FGS-
----GGGFGG---GG-FGSGG-GFGSGGGFG------------G---------GGFGGGG
---FGGGGYG-GGMG--P----------VCP-P-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DR-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXX-X---XXX-XXXXXXXXFEAYISL--RR----VDQQKNEQ
-----------SRMDT-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-SKMDLEGKVANIQ---RDIEFFTTIFQVELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYETIAQKSKEE
AEALYQH-------------KYEEL-QV-TAGKHGD-SVKNSKM--------------EI
SDLNRVIQRLRSE--I---------ESVKKM-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXX--X-----------XXXXX----------XXX-XXXXXXXXXXXX
XXXXXXX------------XXXX------------------------X--XXXXXXXX--
------------------------------------------------------------
-----------------------------------XXXXX-XSYGSGGSYGSG-----GG
SYGSG-G----------GS------Y-GSGSGGGRSGG----------------------
---GGGG--SSYGSGSSSGGHRGG----------------SGG-GGGS------------
--------------SGGRGS--G-GGS------SGGSF---GS-----------SGGR--
-----GS-S---------------------------SGGTK------TTGG---------
---------------------------------------------------------VST
VKFTSTSY-SIVT-R---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFS--S----------------------------------QSAFSSRS--
RRGY---------RS---GFSAGSGGGSR-------------------------------
-----------AVGSVCVARGPCGG-----GGGVGYGGYARSFGSQSLYNLG-GS----K
SISISLVGRSAS--GFRQGGG-----------------------------------FGG-
----GRSFGG---GG-FGGGG-F--GGGGYG------------G---------GGFRGAG
---FGGSSFGFGGFG--P----------SCP-P-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-SQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XXX-XXXXXXXXXXXXXXXXXXX----XXXXXXXX
-----------XXXX------XXXXXXXXXXXXXX--XXXXXXXXXXXXX--XXX-XXXX
XXXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXELS-QM-QTHISDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RTQYEIIAQRSKDE
AEALYQT-------------KXXXX-XX-XXXXXXX-XXXXXXX--------------XX
XXXXXXXXXXXXX--X---------XXXXXX-----------------IEQMHS----AI
ADAEERGERALQDAKQKLLDL---------------EDALQQSKEE-----LA-RL-LR-
-----D-YQ-AL-LG--------------VK-LS-----------LD-V---EIATYRKL
LEGEESR------------MSGE------------------------L--QNHVSI----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVF-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYG-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRARR---GFSARSA-----------------------------------
----------------CSAQSVG-----------RG---RTGFSSRSLSSFG-GC----R
G-GS-RG-----------------------------------------------------
-----RTWGSWG--R-LG-V---------------------------------R-L-G--
-------E-GS-G-G-PG-L-S-----L-CP-P-GG-I-QQ-V---------T-IN-Q-S
L-L-IP-PK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-QI-RV-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSDRPQGLESFFEAYLVRLRTQ----LEELQKKR
-----------GSLDA-----ELKSCQGQEEEYKA--KYEHEANRRATLE--NDF-VVLK
KDADG----VLL-SKMEMESKVEDLK---EYICFLKHLYEEELG-QL-QTQASDMSVVL-
-SMD-------------------NNRCLDF--------RDLIAEV-RARYEEIARTSKAE
AEMLYQT---------K----YREL-QA-CAQLHGN-SMKETKV-------------Q-I
TQLQQTIKKLQSQ--I---------ETVKSQ-----------------NASLQV----AI
ADAEQRGELALKDAQTKLAEL---------------EAALRTAKQDIARL-------LH-
------DYQELMSVK-------------------------------L-SLDIEIATYRRL
LEGEECR------------MSGECASQVTIS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGADGGL-AGTCGLGGVKGSFGS-RCSSVV
KGGSSIVKGGS-------SVVIGGSSIILGSEQGPAVGSGSVSGSSSSS------TSHTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSQQFSSRSAFGLGSR----------------------------HVYSARSS-
GAI------S--GRSQTGGTVCRIGGTCGGG---G-------------------------
---------SGFG-------GYS--------------RFRGSYSSQSLYNLG-GS----R
SIS-SVVGDGASS-FWQSRG---------------------GRGFGGGG-----------
----------------------------GG----HGFGSRS--------------F----
----GGGGFGLRGFG------------PAC-PP-GG-I-RE-VT----------IN-Q-S
L--LQP-LG-VE-VD-PE-FQ-KVK-SQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQVKT---ST--QSNNLEPILESYIAELRRE----LDGLSAER
-----------MRQDS-----EIRTMQDLVEDYKT--KYEEEISKRTNAE--NDF-VILK
KDVDA----AYM-NRVDLQSNVDRLI---KETDFVKFLYEAELS-QM-QTTTSDTNVIL-
-SMD-------------------NNRSLDL--------DSIIQEV-QEQYELIFRRSKAE
TEARYQD---------K----XXXX-XX-XXXXXXX-XXXXXXX--------------XX
XXXXXXXXXXXXX--X---------XXXXXX-----------------IGQVQS----LI
SDAEEKGDEALQDAQQKLQEV---------------EEALHQSKEEMARL-------LR-
------DYQELLSTK-------------------------------L-SLDVEIATYRKL
LEGEEIR------------MSGEFQ--NPVS---------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LDPYFEVYISGLRKQ----LDGLSSEK
-----------IQLES-----ELKSFQDMVEDFKT--KYEEEINKRTAAE--NDF-VLLK
KDVDG----VYM-NKVELQAKLDSLA---DELNFLRNLYEAELC-QM-QKTVSDTSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIANRSRLE
AETWYQS---------K----YEEL-QA-TAGKHGD-SLRDTKA--------------EI
SELNRVIQRLRAE--I---------ENVKKQ-----------------CETIQS----SI
ADAEQRGELALKDARDKLTEL---------------ETALKKAKADLAQQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECS------------SAGGNP--TPFL---------VPAA----------------
-------VVG----------------------------GSSSIGGGYG------------
--GGL------------------------------------------CLGGG------GL
------GF-GAG------------------------SGRG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSRG------SRKSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GS----K
SISISVAGGGGGF--------GVGGGFGG-----------RGGGFGGGSGFGGGSG----
--FGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-ID-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---ST--RSSNLEPIFQAYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDIEFLKVLYDAEMS-QM-HQTITDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AETLYHS---------K----YEEL-QV-TAGKHGD-SLKEIKM--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----SI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSTDLS--SSVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGIG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYS----SG--GGSGGRYGSGGGSGG--------------------------
------------------GY--G-SG---G-----GKHGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEGF------------------------------------------GSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLR-VKAAG------------------------------DTGGFSGRS--
AAVL-GQ-------AAGPAASY----RAAG------------------------------
-----------------------------------KGP-GAGFGSQSLYSLG-GN----R
RSSLGGAAG--GVR-TA------------------------GSSFGPG------------
-----------------------------------------------------PGYGRGR
ATGFAGSMFGSMALG-PV---CP----SACP-P-GG-I-HQ-VT----------V-NR-S
L--LAP-LN-VE-LD-PE-IQ-RVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPILEGYIGNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDLKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIITKIR-AQYEEIALKSKAE
AEALYQSK----------GNQIQEL-QL-AAGRHGD-DLKHTK--------------NEM
SELNRLIQRIRCE--I---------ANVKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELLSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSGG------------
------------------------------------------------------------
-------------------------------------------SSYYRP---------D-
-----------------PS-------TGADAGA---------------------------
----GSVA-------------------------------------------GGSGSAW--
--------ARQTRAKGARVG-----DLK-------DPQDLKGKS------AP--ASAPAR
-KAAR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRRGG---------------------------GGGGRGFSSGS--
AMVSGG------SRRSTSGFSC--LSRCG-------------------------------
---------------------------------------GGGFGSQSLVGLG-GH----K
RISISVAGYGGGSGGRGGSGFGGGSGFGGGSGFGGGSGFGGGSGFGGGRGFGGGSGFGGG
SGFGGGGFGGGG----FGGG-RGFGGGSGFGGG-SGFGGGGFGGGGFGG----GRFGGGG
------GFGGFG--G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-RT-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---SS--HTTNLDPIFQAYISMLKKQ----VDGLTAER
-----------ASQDS-----ELTNMQDLVEEFKK--KYEDEINKRTAVE--NEF-VTIK
KDVDS----SYM-DKTELQTKVDMLT---QENDFLRTLYDAEVS-QL-QQTATDTNVIL-
-SMD-------------------NNRNLDL--------DSIISDV-QSQYEVIAQKSKAE
TEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKTLQD----SI
ADAEQRGEHAINDARGKLTNL---------------EEALQQARENLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEFN--DNVS---------MSVT----------------
-------SSS----------------------------ISSTVTSKAGFGSGGQGSGGRG
FGSGGGG--GG----------------------GGYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--GGGGSGS-RGGS----------------------
--GSGGGGGYSSGSGS---------YGSGGRGSG--------------------------
-------------------SRSG-GG---------G----GSGSRGG-----SGSGGGGF
S----SGGGSRGG--FSSGGGSRGG-SGSG-----GGGFSSGGGSRGGSS------SGGG
VSSSERGASGSGETC------------------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQMSCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSRG------SRKSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GS----K
SISISVAGGGGGF--------GVGGGFGG-----------RGGGFGAGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGSPG
------GFG------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RSVNLEPIFQAYIDNLKRH----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QEIEFLKVLYDAEMS-QM-HQTITDTNVIL-
-SMD-------------------NSRSLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKM--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----SI
ADAEQRGEHALKDARNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSTDLS--SSVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGSSGG--------------------------
------------------GY--G-SG---G-----GKHGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEGF------------------------------------------SSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSAHSRG----HS-RGGFSS---RGGFSSKSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-L---------------------------------R-F-G--
-------E-WS-G-G-PG-L-S-----L-CS-P-GG-I-QE-V---------T-IN-Q-N
L-L-TA-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RI-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LEQLQGER
-----------GSLDA-----ELKACRDQEEEYKS--KYEEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYLYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNCYLDF--------SSIITEV-RARYEEIAQTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RIQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
TDAEQRGELALKDAQVKVDEL---------------EAALRMAKQNLARL-------LC-
------EYQELMSTK-------------------------------L-SLDVEIATYHRL
LXXXXXX------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVMSGGVGGGL-GSTCGLGSGKGSPGS-CCISIV
TGGSNTILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGG----GSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYS----SG--SGSGGRYGSGGGSKG--------------------------
------------------GS--S-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-FKSGG------------------------------DKGTFSVHS--
AVMP-RK-------AVGSLTSY----RAAG------------------------------
-----------------------------------KGA-GTGFGSRSLYSLG-GN----R
NVSFSVAGG--GVR-AG------------------------GYSFGLS------------
-----------------------------------------------------SAYGGGR
ASGFAGSMFGSVALG-PT---YP----SICP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPIFENYISTLRRQ----LETLSGDR
-----------VRLDS-----ELQSMRDLVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADA----AYT-AKVELQAKVDSLD---KDIKFLKCLYDAEVA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIITEVR-AHYEEIALKSKAE
AEALYQTKPYLITYFLSLG-NIQEL-QL-AAGRHGD-DLKHTK--------------NEM
SELNRLIQRIRCE--I---------TNVKK-----------------QCSNLET----AI
ADAEQRGDNALKDARAKLNEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
----------------------------------------SSGYVYH-P-----------
-----------------SS-------VTTDLGP---------------------------
----SSVA-------------------------------------------DSSSSTQ--
--------SGQTKAKGAPVG-----DLK-------DSQ---NKS------TS--VSSPAR
-KTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--GIQ-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYV-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAD
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TT--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRGFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGI-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSSSGGAGGGGSY-----VSGG
-------------------------------------------YGGG--SGWGGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---G----------GS-----------------------------------YAGSGR
S----SRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGAFSGCS--
VVLS-GS-------S---SPSY----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-CA----Q
SSSFNMASG--RGR-AG------------------------GY-----------------
------------------------------------------------------GFSRGR
ASSFGGSMFGSVVLG-PM---CP----SLCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PK-IQ-KVC-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQQDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---REIKFFTCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------NSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
TDAEQRGHCALKDAQAKLDEL---------------EAALLQAKEELARM-------MC-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---A-------
---------------------------------------------TAGTGAG--------
-----------------------------------FGYSSSGTYG-YRP-----------
-----------------SS-------VGGGYGF---------------------------
----LLGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKSRLGSTS-----EIK-------DLS---GKT-------P--ALSSPT
KKTPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLNLY-PGG------------------------------ERLAFSGCS--
AIIS-SR-------VSSSTASF----RASG------------------------------
----------------------------------IK--GTATFGSRSLFNCG-GG----R
RPALSSA----AGR-GG------------------------SALGSCA------------
------------------------------------------------------ATGGGR
RGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LSP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQLDL---NN--CKNNLEPILEGYTSNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDVVEEYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFLKCLYEGEIA-QL-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAQVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SDLNRMIQRIRSE--I---------GNVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARAKLDEL---------------DAALLQAKEELARM-------MR-
------EYQELMSTK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTST---G-------
-------------------------------------------AGGTGFSMG--------
-----------------------------------FGAL--SSYS-YKSS--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-GS-----ELK-------DAP---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGAFSGCS--
VVLS-GS-------S---SPSY----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-CA----R
SVSFNMASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFSRGR
ASGFAGSMFGSVALG-PM---CP----SLCP-P-GG-I-HQ-VI----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVC-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQQDL---DN--CKNNLEPILEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---REIKFFTCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------NSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
AELTRLIQRLRSE--T---------ESVKKQ-----------------CSNLET----AI
TDAEQRGHCALKDAQAKLDEL---------------EAALLQAKEELARM-------MC-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSMA---G-------
---------------------------------------------TAGTGAG--------
-----------------------------------FGYSGSGTYG-YRP-----------
-----------------SS-------VGGGYGF---------------------------
----LLGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSTS-----EIK-------DLL---GKT-------P--ALSSPT
KKTPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------SPACSGG-----------RS---RGSFSSRSLGSLG-GC----P
R-GS-RG-----------------------------------------------------
-----RAWGSGK--R-LG-V---------------------------------W-F-G--
-------E-GS-D-R-PG-F-S-----L-CP-P-GG-I-QE-V---------T-IN-P-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RV-LN-NQ-FA-SFI-DK-VQF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGSPQNLQPVFEAYLAQLRKQ----LEQLQGER
-----------RALDA-----ELKTFQDQEDEYKA--KYEEEARKHATVE--NDF-VVLK
KDVDG----VFL-SKMELEGKLAALG---EYTCFLKRLYEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRCLDF--------SDIIAQV-RARYEQIAQTSKAE
AEALYQT---------K----YQEL-QV-SAELHGD-NMKETKI-------------Q-I
SQLHQEIQRLQSQ--I---------GSLKKE-----------------NANLQA----AI
TDAEQRGDLALQDAQAKLDRL---------------DAALRTAKQDLAQL-------LR-
------DYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECTSQVTIS----------------V--AGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STNVSGGAGGSL-GVPSGLLGEKGSFGS-CCSSMV
TGGSSVILGSK---------------------EGPDWGSCSVSGSGAGF----SSSCHTI
LKKTVESSLKTSVMY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYSLG-GA----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYP------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSCG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASH----CAAG------------------------------
-----------------------------------RGA-GAGFSSRSLYSLG-GN----R
RISFSVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGAGR
ASGFAGSMFGSVGLG-PA---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CKKNLEPIFEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NSRDLDL--------DSILAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEI
AELNRLIQRIRCE--I---------GNVKRQTFSVSN---EPAPCPLWCTSLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALYQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISIISS--------------
------------------------------------------------------------
----------------------------------------S-SSSYHHP-----------
-----------------SS-------AGADLRA---------------------------
----SAVP-------------------------------------------GSSGGTR--
--------SGQTKTKGARGG-----DLK-------DSQ---GKS------TP--AGTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MELEGKLASLR---EYLCFLRQLNEEELG-QL-QTQASDMSVVL-
-SMD-------------------NNRGLDF--------SDIIAEV-RARYEEIAQSSKAE
VEMLYQT---------K----YQEL-QA-SARLHGD-SMKETKV-------------Q-I
SQLQQASQRLQSQ--I---------ENLKKQ-----------------NADLQA----TI
ADAEQRGELALKDAQSKLDEL---------------EAALRAAKQDLARM-------LR-
------DYQELMSTK-------------------------------L-ALDVEIATYRRL
LEVEESR------------WGPGNMGEMGAE----------------D--GPP-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------L--------------KC----------S-PC----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLRYC-AGA------------------------------ERRGFSGCS--
AVIA-GR-------VSGSAASF----RA-G------------------------------
----------------------------------VQ--GTAAFGSRSLFSPG-GG----R
RLALSVA----AGR-PG------------------------AYALGQF------------
------------------------------------------------------RG----
-------HRRRAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-VE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VGGR
EDVDA----AYM-NKAELQAKVDSLT---DEIKFFRCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIDEVR-AQYEEIAQKSKAE
AEALYHSK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLTQRIRSE--I---------GSVKKQ-----------------CSNLEM----AI
ADAEQRGDNALKDAQAKLEEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPNSMS-----------ISVVSSTSA---G-------
-------------------------------------------AGGAGFSVG--------
-----------------------------------FGAS--SSYS-YKPA--------A-
-----------------PD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPL---VKA-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------ST---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GV----R
SISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PM---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQSKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGESRSR-SSTT-----DYK-------DAL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GFGG----FGSG-GGG--FGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEETD------------FLGACA--SFVG---------LERDTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYGSG------
---GGGGGGRGSYGSGGGS-----------YG----------------------------
-SG---GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRTQR---GFSAHSA-----------------------------------
----------------CSARSRG-----------RG---RGSFSSRSLSSFR-GR----R
G-AS-SG-----------------------------------------------------
-----RIWGSGE--R-LG-M---------------------------------Q-F-G--
-------E-RK-G-R-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-ME-ID-PQ-FQ-MVR-TQ-E------------------------------
------TQ-EI-RA-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGSPQSLEPFFEDYLTHLRKK----LELLQRER
-----------GALDA-----ELKTCQDQEEEYKA--KYKQEAHTRATVE--NDF-VILK
KDVDV----VFL-SKMELKGKLEALR---EYICFLRRLYEEELS-QL-QTQVNDTSVVL-
-SMD-------------------NNCCLDF--------SDVIAEV-RARYEEITRTSKAE
AEALYQT---------K----YHEL-QA-SVQLQGD-SMGETKA-------------Q-I
SQLYQAIQRLQSQ--I---------ENLKKQ-----------------NGSLQS----AI
TDSEQRGELALKDAQAKLEEL---------------EAALRRAKQDLARL-------LR-
------DYQELMSTK-------------------------------L-ALDVEIATYRRL
LEGEECR------------MSGECTSQVTI------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------VASY----HAPG------------------------------
-----------------------------------QRG-GAGFSSRSLYSLG-GN----Q
HVSFHVANS--GIW-AG------------------------GYSSEHG------------
-----------------------------------------------------TGYGGSQ
PRGFAGSMFGSLALA-PG---CL----SVCP-P-RG-I-HR-VT----------V-NK-N
L--LAP-LN-ME-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KL-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRQNLEPIYEGHISSLRKQ----LQMLSGDR
-----------VRLDS-----ELRSMRDMVEDYKK--RYEVEINQRTEAE--NEF-VVLK
KDTDA----AYI-ARVELQAKVDSLD---KDMKFLKCLHDAEID-QL-QTHTSETSVIL-
-SMD-------------------NNRDLDL--------DSIITEVR-THYEDITQKSKTE
AEALYQTK-------------IQEL-QL-AAGRHGD-DLKHTR--------------NKM
SELSQPIQKIRCD--I---------ISVKR-----------------QCSNLET----AI
ADAEQRGDSALKDAWTKVDEL---------------EGALRQAKDELSRL-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSGENPSSVR-----------ISVISSS-------------
------------------------------------------------------------
------------------------------------------GYG-HHP-----------
-----------------SS-------RRTDLEV---------------------------
----SSAA-------------------------------------------IKHGSPR--
--------SGQTKTQGAQAK-----DPK-------DSQ---DRS------VP--AGALAR
K-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFNCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------S---STSY----RAGG------------------------------
-----------------------------------KGL-GGGFSSRSLFSLG-GA----R
SISFNVASG--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRVR
ASGFAGSMFGSAALG-PA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSADR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---REIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKYTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMSVK-------------------------------L-ALDIEIVTYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSAP---G-------
---------------------------------------------TMGAGAG--------
-----------------------------------FGFGGAGTYS-YWP-----------
-----------------SS-------V-GGYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DSQ---AKT-------G--ALSSST
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSVCRSG----------------------------G-RGFSSGS--
AGLVSF------QRRSTSSSV----RRSGG-GGG--------------------------
---------RFSG-------GFCGSG-------GG----GGGFGSRSLVNLG-GC----K
SISFSVARGG-GRSGFGGGS------------------------FGGG------------
-SFGGGGYGGGS----FGG-------G-GYGGGS--FGGS-FGGGGYG----GGSFG-GV
--GY-G-----GGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHSLEPFFEAYISDLRGK----VDHLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEEEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQVKVDNSR---HEIEFLTALYEAELS-QM-QTHISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-SVKNSKM--------------EI
AELNRMIQRLRSE--I---------DSVKKQ-----------------ISQVQQ----SI
SDAEQRGENALKDAQNKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECS--PNVS---------VSVSTSHT------------
---------------------------------------SISGGSVRG--G---------
-------------------------GGY--------SSG-GGSYSSGGGG-------GSG
GYSS---GG--------VS-----------YG----------------------------
-SGGGGG-SYS------------T-GGSSGGRRGGSGGG-G-------GS---SGGRG--
------SSGGSFGSSGGRGSS-----------------------------------SGGQ
K----TSSGSSSI-------KFVST-TYSR------------------------------
------------------------------------------------------------
--------------------K---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYCLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALE-SV---GP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVTGG--SVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASQHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AV
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STMA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQMSCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSRG------SRKSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GS----K
SISISVAGGGGGF--------GVGGGFGG-----------RGGGFGGGSGFGGGSGF---
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-ID-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RSVNLEPIFQAYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QEIEFLKVLYDAEMS-QM-HQTITDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKM--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----SI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSTDLS--SSVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYG----SG--GGSGGRYGSGGGSGG--------------------------
------------------GY--G-SG---G-----GKHGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEGF------------------------------------------SSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFSSRSGYRCGGG--------------------------GRGGFSSGS--
AGLVSY------QRRSTSSSV----RRSGG-GGG--------------------------
---------RFTS---------------G----VCGGGAGGGFGSRSLVNLG-GS----K
SISISVAGGGGR-GGFGSGYGS-I--FG-------------GGGFGGG------------
-GFGGGGFGGGL---------------------GGGFGSGGFGGGGFGR----GGFG-GG
--------SFGGNFG------------PGY-P--GG-I-HE-VI----------VN-Q-S
L--LQP-LN-VE-VD-PE-IQ-KIK-SQ-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINT---TT--RTQNLEPYFEAYISSLRAR----VDQLKSEQ
-----------SQMDS-----ELKNVQDLVEDYRK--KYEDEINKRTNAE--NEF-VNIK
KDVDA----AYI-TKVNLQATVDNLR---QEVEFLTALYQAELA-QM-QTHISETNVIL-
-SMD-------------------NNRHLDL--------NSIIDEV-KAQYEEIAQRSKAE
AETLYQS---------K----YEEL-QI-TAGQHGD-NLKNSKI--------------EI
SELNRVIQRLRSD--I---------DNVKKQ-----------------ISAVQQ----SI
SDAEQRGENALKDAQNKLNEL---------------EEALQKAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------SISGGSIRG--G---------
-------------------------GG----------SG-GGSYISGGGS----------
SYSSGGGGGSG--S----------------YS----------------------------
-SRG-GGGSYSSGG-GGGGGGSSGGY-------------G--------SRGSSGGHRG--
------GSGSSFTSSGGRGSS-----------------------------------SGGT
K----TSGGSSSI-------KFVST-SYSQ------------------------------
------------------------------------------------------------
--------------------GGTR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CWAQR---GFSARS------------------------------------
----------------CSAHSGG----W-------G---KASFSSRSLSSFG-GC----R
R-GF-CG-----------------------------------------------------
-----RTWGSGG--R-LG-V---------------------------------R-F-G--
-------E-GS-G-G-PE-L-S-----L-CP-P-GG-I-QE-V---------T-IN-P-N
L-L-TP-LK-IE-ID-PQ-FQ-AVR-TQ-E------------------------------
------TR-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSVSPPGPEPFFEAHLAQLRKQ----LEQLQRER
-----------GTLDA-----ELKSCRDQEEEYKA--KYEQEAHMRATAE--KDF-VVLK
KEVDG----IFL-SKMELDGKLEELG---EYICFLRHLYEEELC-QL-QTQVSDTSVVL-
-SMD-------------------NSRCLDV--------NDIIAEV-RARYEEIARTSKAE
AEAVFQN---------K---VXXXX-XX-XXXXXXX-XXXXXXX-------------X-X
XXXXXXXXXXXXX--X---------XXXXXX-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXX-------XX-
------XXXELMSTK-------------------------------L-GLDVEIATYRRL
LEGEECR------------MSGECTGWVTIS----------------A--VGGSTAM---
---SGGVGGD--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------PVGTCGLGGGKGSFGS-CGSSVV
TGGYDVSLGSGQCSA------------------LGSLGSCSVTGSGSS------SSCCTI
LKRTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLHLY-SGG------------------------------ERLAFSGCS--
AVIS-GR-------VSSCCTSF----RA-G------------------------------
----------------------------------VK--GKATFGSRSLFNPG-AS----R
RLALSTA----SRR-GG------------------------SALRPCA------------
------------------------------------------------------ATGGGR
LGGFVGTVFGSAGLG-LA---CP----SVCP-P-SG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-FQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NT--YKNNLEPILEGYISTLQKQ----METLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEVEINRRTAAE--NEF-VELK
KDVDT----AYM-NKVELQAKVDSLT---DEIKFFKYLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDISLKSKAE
AEALYQSK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SDLNRLIQRICAE--I---------GSVKKQ-----------------CSNLET----AI
TDAEQRGDCTLKDAQAKLDEL---------------EGALYQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MYGDYPNSMS-----------ISVISNTIA---R-------
-------------------------------------------AGGAGFSVG--------
-----------------------------------FGAS--STYS-YKPS--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DLP---AKT-------S--GSRRAT
KKALR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------SNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELSRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------V---MSPSLS-----------L-SLSPAII---S-------
---------------------------------------------S--------------
----------------------------------------TSGSS-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-STAG-----DYK-------DAL---AKG-------S--SLSAPS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVTS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVCEVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSICRIGG---------------------------G-RGFSSGS--
AGLVSF------HRKSTSSSV----RRSGGGSGG--------------------------
---------RFSG-------GFCGSS-------GGS---G-GFGSKSLVNLG-GG----R
SISMSVAGGGH-CGGMGGGS------------------------FGGG------------
-GF-----GGGG----FGG-------G-GFGGGFGSGGGGGFGGGGFGS---GGGFG-GG
--GYGG-GRFGGGFG------------PVC-PP-GG-I-QE-VT----------VN-Q-S
L--LQP-LN-ME-VD-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTHNLDPYFESYIANLRKQ----VDQLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRS--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQAKVDNLQ---QEIDFLTALYREELS-QM-QTHISETNVIL-
-SMD-------------------NNRTLDL--------DSIISEV-KAQYDDICQRSKAE
AETFYQS---------K----YEEL-QV-TAGKHGD-SVKTSKM--------------EI
SELNRIIQRLRSE--I---------DSVKKQ-----------------IQHMQQ----SI
SEAEQRGENALKDAQNKLNEL---------------EDAMTQAKEELTRL-------LR-
------DYQDLMNTK-------------------------------L-ALDMEIYKGAL-
L--------------------GGKR--VDLS---------AAVSTSHT------------
---------------------------------------SMSGSSSRG--G---------
-------------------------GGY--------GSG-GGSYGSGGGSGG-----GYG
GGS----SG--------GS-----------YG----------------------------
-------GGSGSG---GGGGSYGGSGGSSGGHRGGSGGGGG-------SSGGSYGSS---
--------G-----GGRGGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQMHHY-PGG------------------------------ERLGFSGCT--
VEGG--R--------KDRRTEF----ND-G------------------------------
----------------------------------VKXXXXXXXXXXXXXX----------
-------------X-XX------------------------XXXXXXX------------
-----------------------------------------------------XXXXXXX
XXXXXGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-ME-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---NN--CKKNLEPFFEGYISTLRKQ----LEALSGDR
-----------VRLDS-----ELRNMQDLVEESKKXXXXXXX--XXXXXX--XXX-XXXX
XDVDA----AYM-NKVELQAKVDSLA---DEIKFSKYLYDEEIA-QL-QSHISDTSVVL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------IQEL-QL-TAGRHGD-DLKLTR--------------AEI
SEINRLIQRIRSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPNSVS-----------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQMSCKSRRGG------GG---------------------GFRGFSSGS--
AVVSGG------SRRSNTSFSC--ISRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISSSVAGNSGG--YGGSSFGGSG-GFGG------------GSGFGGGRGFGGGSSFGGS
GGFGGG----SG----FGGS-RGFGGGSRFGGGGSGFGGGGFGGGGFGG----GRFGGGP
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GT--RTANLDPIFQAYIGSLKKY----VDSLSAER
-----------TSQES-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NDF-VTIK
KDVDS----CYM-DKTELQSRLDILA---QEVNFLRTLYDAELS-QL-QQDVTDTNVIL-
-SMD-------------------NNRDLDL--------DSIIAEV-QSQYEMIAHKSKAE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHAIKDARGKITDL---------------EEALQQARENLARL-------LR-
------DFQELMNTK-------------------------------L-TLDVEIATYRKL
LEGEECR------------MSGDFS--DNVS---------VSIT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GGR---------------------GG----G-GSTYGSGGRSSG------SR
G-SGSGSG-GGGYSSGGGS--RGG--SGG-------------------------------
-----------------------GGYSSGGGSRGGSS-SGGGYGSGGGSRGGSGG---GV
SSGGGSRGGSSSGGAGY--------G-------------SGGGSRGG-----SSSG----
-----------------------------------GGGYSSGGGSRGGSS------SGGA
VSGSEKGGSGSGEG---------C---------------------------------GSG
---------VTFAFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPLFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQITIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGDL-GSICGLSGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---SP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHIK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQLAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGARAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRRQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
XXXXX----XXX-XXXXXXXX-XXXX---XXXXXXXXXXXXEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-TQYEEIALKSKAE
TEALYQTK-------------FQEL-QL-AAGQHGD-DLKYTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEEYR------------MSGEYTNSVS-----------ISVISSSTW---T-------
-------------------------------------------TGXX-TSLG--------
-----------------------------------KASA-LSSLN---------------
--------------------------KKTR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFNCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------S---STSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLFSLG-GA----R
NISFNVASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGRVR
ASGFAGSMFGSAALG-PV---CP----SVCP-P-GG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSADR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKYTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMSVK-------------------------------L-ALDIEIVTYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINGSAP---G-------
---------------------------------------------TVGAGAG--------
-----------------------------------FAFGGASTYG-YWP-----------
-----------------SS-------V-GGYGM---------------------------
----LSGGCVT-----------------------------------G----SGNYSPR--
--------G-EAKTRLGSAS-----EFK-------DSQ---AKT-------G--ALSSST
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------SKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KPF-SGDFGSRSLYNLG-GT----R
SISFNMASS--SGR-AG------------------------NY-----------------
------------------------------------------------------GLSRGR
TSGFAGSMFGSMALG-PV---CP----PVSP-T-GG-I-HQ-VT----------I-NK-S
L--LVP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------W-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISTLQKQ----LEVLSGDR
-----------VRLDS-----ELRSTRDMVEDYKK--RYEEQINKRTSAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKLFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRSLDL--------DSIIAEVQ-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLHSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEFTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGSGAS--------
-----------------------------------FGFSGTGTYG-YRP-----------
-----------------SS-------VGRGYSI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-ESKTRLGSAS-----EFN-------FPP---GKT-------P--AVSLPT
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
SSLQGSM-SRHFSSRSG----LR--------------------------SGGGFSSGS--
AGVVSF------QRRTTSS-S---VRHGG-------------------------------
-------------------------------------G----------------------
-------GGGRFSGGRCGGGGGGF-SVAR------G---GGRGGFGGGYG-------GGG
F----GG-GG-------YGG-GGFGGG-GFG-------GIGSLG--FGS---GGGFGG--
---GGFG---GGGFG------------PVC-PP-GG-I-QE-------------------
--------------------------TR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---TT--RTHNLEPYFESYINNLRRR----VDQLKSDQ
-----------SRMDS-----ELRNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-TKVDLQAKVDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQKSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-NLKSTKM--------------EI
SELNRVAQRLRSE--I---------DSVKKQ-----------------ISALQQ----SI
SDAEQRGENALKDAQGKLAEL---------------EDALQKAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVN----------------
-------TSH----------------------------TTISGGGGRGGGGFG-SGGGGG
YGSGAGSYG----------------------------SG-GSSYGSGGGGGG------SY
G-SRGGGW-GSGGSSGGRGSSSGG-RHGG---GGGGYGGGSFGSRSLVGLGGTKSISISV
AGGGGSFGAGAGFGGRGGGFGGGS--GFGG----GGFG-------GGGFGGGRFGGGGGF
G--GFGGGGFGGYGSGGKGAGSGGGGYSSR----SGSYSSGGRGSSS-----RGGGGGGY
G----SGGGSRGG--SVSGGGYSSG-GGSRGDSVSGGGYGSGGGSRGGSGS-----GGGS
GGAYGSGGGSRGSSS--------S---------------------------------EKN
---------VEACLCTSNEQQVKPCH----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRLSIRRS---------------------------------QSGSYSSGS--
AILPGR------GRRVAGSSS---VVRF--------------------------------
------------------------G--------SCSRGRGAGSSSQSLINLG-GH----K
SILSSVAGAGLGQGSLGYG---GY------------------------------------
------------------AV-GGFGSG-RFG-------G-----------------GGFG
--AGGFGGLGGGPFG------------PNA-CP-GG-I-HE-VV----------TN-Q-S
L--LEP-LN-VK-ID-PE-VQ-QVK-TQ-E------------------------------
------R-EQL-KV-LN-NQ-FA-TFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLNV---ST--RTTNLDPVFETYISLLRGQ----VDSLKSQK
-----------NQQEL-----ELKTTQDSVEDFKK--KYETEINARTNAE--NDF-VVLK
KDVDS----AYV-GKVDLSTRTNSVQ---QEIDFLTVLYETELA-QV-QKTVSDTNVIL-
-SMD-------------------NNRTLNL--------DGILEEI-RSQYDDIVQNAKSE
ADSLYQA---------K----YQEL-QV-TAGKHDD-DVKVLKA--------------EI
SELNRVIQRLRAE--I---------DRVKKQ-----------------SAAVQE----SI
LEAEQKGEKTVKDAQDKLVHL---------------EDALHQAREDLTRL-------LR-
------DYQELLTVK-------------------------------L-ALDVEIATYRKL
LEGEESR------------ISGEVS--SSVS---------YSVV----------------
-------TSS----------------------------ISSSGASSTSLG-LGGKSSGDG
--SSRSSS--------------------------------GVDYSSGTRSG---------
--STRATF-GSAGTSSGYGAQESGSRKTQGYSSGQGSQEGSYTRVKF-------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFSSQSAFSSRC----------------------------RRFYSTGS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCQVRGRCGGGGG-----GGYGSHARGFGSRSLYNLG-GS----K
SISISLVGRSASG--FCQGGGA-------------------GGRFG------------GG
GRSFGG----------GG-----FGGG--------GFGGG-----GFG----GGGYGGGG
--FG-GSNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTNNLEPILENYISELRRQ----VDFLNTEQ
-----------MRQNS-----EVRNMQDVVEDYKN--KYEEEINRRANTE--NDF-VVLK
KDVDA----AYM-SKVDLESKVNVLF---GEISFLKYLFDMELS-QM-QTHISDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RTQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-SAGRQGD-ELKNSKM--------------EI
AELNRTIQRLQAE--I---------GNVKKQ-----------------CANLQN----AI
ADAEQRGELALKDAKNKLAEL---------------EDALQKAKQDMARL-------LR-
------EYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LSGEGVGPVNIS---------VITN----------------
-------SVS----------------------------SAYGGGSGFGGGL-----G-GG
-------------------------------------------L------------GGGL
G-------------G---------------------------------------------
---------------GGS------GSYYSSSSGGVGMGG-------------------GL
SVG---SSG---FSAGSGRS----------------------------------LGMGFG
S----GGGSSSSV-------KFVST-T-S-------------------------------
---------------------------------------------------------SSR
KSFKS-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
RISFNVAGG--GVR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTTAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KEIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
VELNRLIQRIRCE--I---------GNVKKQ-----------------RASLET----AI
ADAEQRGDNALKDAQAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGVDLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------SGQTKTTEARGG-----DLK-------DTQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTYKSGVP------------------------------GKGGFSGCS--
AVLP-GG-------RGASSGSY----RAGP------------------------------
------------------------------KAAGAAGV-VGGFGSRSLYSLG-GT----R
SISLNVAGG--GGARNS------------------------GYGFGAG------------
-----------A-------G--------------------------------GYGPGRVR
ASGFAGSMFGSVALG-PA---CP----SSCP-P-GG-I-HQ-VT----------V-NQ-S
L--LQP-LD-VK-VD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-DL-LQQLDL---SN--CKNNLEPIFEGYISNLRRQ----VEGLNGDR
-----------VRLDS-----ELRSMRDLVEDFKK--RYEEEINKRTAAE--NEF-VVLK
KDVDA----AYT-NKVELQAKVDSLD---GEIKFLKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIDEVR-VQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELSRLIQRIRSE--I---------ENAKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKMDEL---------------EGALHSAKEELARL-------LR-
------DYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYSNSVS-----------ISVISSSTA---T-------
------------------------------------------------SAGG--------
-----------------------------------FGLSSASAYG-YRP-----------
-----------------GS-------AGGGFGG---------------------------
-------------------------------------------CVTG----GGSCTP---
--------RGDVRTSKGSAG-----EFK-------DTL---TKA-------P--ALSSPT
KKTTR-------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-----------------------------Q-VRF-LE---------------------Q-
QN-QV-LET-KW-DL-LQQLDL---SN--CKNNLEPIFEGYISNLRRQ----VECLNGDR
-----------VRLDS-----ELRSMRDLVEDFKK--RYENEINRRTAAE--NEF-VVLK
KDVDA----AYT-NKVELQAKVDSLD---GEIKFLKCLYEGREVDKG-ETHIGNSSPFG-
-WIE-------------------NQESREL--------RGLMEALRRAEYNNIDRH-DPL
FTRSLQTR-------------IQEL-QV-AAGRHGD-DLKHTK--------------GEI
LELNRLIQRIRSE--I---------GNVKKQ-----------------CANLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALNSAKEELARL-------LR-
------DYQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------M-SRQLSC---SSRGGG--------------------------GGRGFSSGS--
VLVSGG------SRRVASTSC---MMRK--------------------------------
---------------------SISM--------SVAGSGGGGFGRHSIAVVS-SS----V
SMTSGVG-SGSGGGGFGSG--GGF-SSGG------G------SVSGGGYGSGGGSRSGGG
YGS--GG-GS-------GSG-GGYSSGGGSR-------SGGGFG--SGG---GGRAGGL-
----LGAGRGPGGFG------------PAC-PP-GG-I-QA-VT----------VN-Q-S
L--LQP-LD-LK-VD-PE-IG-NVK-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQVNT---TT--QTSDLSALFEAYISSLKQQ----VDVLNAQR
-----------TQQDS-----ELRTIQDRVEEYKK--KFEDEINSRTNAE--NDF-VLLK
KDVDA----AFM-VKVDLNTKVEGLQ---REIEFLKVFYEAELS-EV-QRNVSDTSVVL-
-SMD-------------------NNRSLDL--------DSILQEV-KAQYEEIAQRSKAE
AEALYQY---------K----YQEL-QV-SVGKHGD-DLKVVKT--------------EI
SELNRTIQRLRAE--I---------EHVKKQ-----------------CASVQE----AI
LEAEQRGERTVKDAQAKLVEL---------------EEALQMAREDLARM-------LR-
------DYQELLSVK-------------------------------L-SLDVEIATYRTL
LEGEECR------------LSGDFS--SNVS---------YSVV----------------
-------KSV----------------------------SSTQGLSQS---SLG-SGGR--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------FSGSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSRSLFCMG-GS----R
RLALSS-----SGR-ST------------------------GFALGHG------------
------------------------------------------------------GASGGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-AL-LQQLDL---NN--SKRSLEPVHESYISNLQKQ----LETLSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQVKVDTLT---NDIKFFKVLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRQLDL--------DSILTEVR-AQYEEIAVKSKTE
TENMYQCK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
TEINRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LEGEESR------------MAGEYPNFVS-----------LSVISSSNA---G-------
-------------------------------------------PGGAGFSVD--------
-----------------------------------FGSS--SSYN-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCS-S------ELK-------DPS---AKA-------A--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQLSCRPNA-------------------------------ERGDLSSLS--
AVLA-RK-------GGSSSGSY----RAGP------------------------------
------------------------------KVAGAAGV-VGGFGSRSLYSLG-GT----R
SISLNVAGG---CARSS------------------------GYGFGAG------------
-----------A-------G--------------------------------GYGPGRVR
ASGFAGSMFGSVALG-PA---CP----SSCP-P-GG-I-HQ-VT----------V-NQ-S
L--LQP-LD-VK-VD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPIFEGYIGNLRRQ----LEGLSGDR
-----------VRLDS-----ELRSVRDLVEDFKK--RYELEINRRTEAE--NQF-VLLK
KDADA----AYT-VKVELQAKVDSLD---KEIKFLKCLYDAEIA-QI-QTHVSETSVIL-
-SMD-------------------NNRDLDL--------DSIIEEVR-SQYEDIALKSKSE
AEALYQSK-------------IQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELNRLIQRIRCE--V---------TNVKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKLDDL---------------EGALHSAKEELARL-------LR-
------DYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------IWSVNEQVP---CVEHC---
-------------------------------------------TNHLGEHNT--------
-----------------------------------VISSGGGGYG-YRP-----------
-----------------SA-------VSGGYSA---------------------------
----SLAGDAK---------------------------------VKV-------------
----------------PNTS-----EPK-------DVL---VKT------AS--GGGSPA
KKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MNRQFTCKPGA-------------------------------ANRGFSGCS--
AVLS-S-----------SSSSY----RAGG------------------------------
-----------------------------------KGL-GGGFSSRSLYSLR-GA----R
SISFNMSGS--SGR----------------------------------------------
-----------T-------A--------------------------------GYGYGRNR
ASGFAGSMFGSGALG-PS---NP----PLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQTHF---ME--AESSEVCLGEGEFEQSASQ----LCHYGE--
-----------SQVSS-----VISGIRQ--------------------------------
------------------------------------------------------PPLFH-
-SSP-------------------PPRM--------------------RRFQ---------
-----------------------EL-QL-AAGRHGD-DLKHTR--------------NEI
TELTRLIQRLRSE--I---------ESVKK-----------------QCSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------MR-
------EHQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSTS---G-------
---------------------------------------------AVGAGTN--------
-----------------------------------FGFSSTGTYG-YRP-----------
-----------------SS-------VGGGYSL---------------------------
----LSGGCVT-----------------------------------G----SGNCSP---
--------RGETKARLGSAS-----ELK-------DVS---GKT-------L--ALGSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-MSIRSTMRTQSS--S----------------------------------QRGFSASS--
ARAPGG----S--RS---GFSCVSVSRSRGTGGA--------------------------
----------------------------------GGVYGGAGFGSRSLYSLG-GT----K
R-ISIGGGSCGLNSGYG-------------SRVGGGYG------FGGG--------AGS-
----GFGFGAGAGSG-FGFGG-G----A-------------------------------G
-------FGGS----------GF----PVCP-P-GG-I-QE-VT----------VN-Q-N
L--LTP-LN-LQ-ID-PT-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LDT-KW-AL-LQEQGT---RT--VTQSLEPLFEQYINNLRR----QLDSILGDR
-----------GRLDS-----ELRSMQSTVED------YKNXXXXXXXXX--XXX-XXXX
XXXXXXXXXXXX-XXXXXXXXXXXXX---XXXXXXXXXXXXXXX-XX-XXXXXXTSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT-------------KYEEL-QV-SAGRHGD-DLRNTKQ--------------EI
SELNRMIQRLRSE--I---------DHVKKQ-----------------CASLQS----AI
ADAEQRGELAIKDAKNKLADL---------------EDALQKAKQDMARL-------LR-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGE------------------------G--VGQVNIS---
------------------------------------------------------------
----------------------------------VVQSTV-S--GGYGGASAI-----GG
---------------------------------SSGLG----------------------
---GGSG--YSYGSGHSLGG--------------------GFSSGSG-------------
-----------------RGL--G-GGF--------S------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQLSSKFSGRAGGGG-----------------------GGRSRGFSSGS--
ATLSSG------SRKSGSNFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVSLG-GT----K
SISISVAGGGGSF--------GSSGGFGG-----------RGGGFGGGSGFG------GG
RGFGGGGFGGGG----FGG--GRFGGG--------------------------------G
------GFGGPGGFG------------PGGLPG-GG-I-RE-VS----------IN-D-S
L--LQP-LN-VQ-VD-PN-IQ-HVK-SW-E------------------------------
------R-DQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVYF---GS--HRINLDPIFQTYIADLKNI----VDRLSAER
-----------TSQDS-----ELSNMQDHVEDFKK--KYEDEVNKHTAAE--NEF-VTLK
KDVDN----AYL-VNGELQAKRDVLR---QEAEFLKTLFDTEVS-QT-QQIITETSVIL-
-SMD-------------------NNRNLDL--------DSIITEV-QNQYEAIAQKSKTE
AETLYES---------K----YEEL-QV-TAGKHGD-SLKEMKS--------------EI
NEMNRVIQRLQGE--I---------AHVKKQ-----------------GNNVQD----AI
AEAEQKGENALEDAKQKLSEL---------------EDALQQAKEDLARL-------LR-
------DYQDLTATK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSEDLS--NSVT---------VSMT----------------
--------SN----------------------------ISSNMSSNTGFGGL----GGRG
SS----S--GG----------------------GRYSSG-SSSYSSGGRGS-------S-
--------------------SRGG--SGGGGSSSGG------------------------
--------GYG----SG--GGSGGGYGSGGGSRG--------------------------
------------------GS--G-S----G-----GGYSSG-------------------
------GGGYS------SGGGSRGG-SGSG------GGYGSGGGG---------------
-SGSEKGASGSGKGC------------------------------------------EST
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAAGGFGG-----------RGGGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG--G-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RPINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QEIEFLKVLYDAEIS-QI-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AEALYHS---------K----YEEL-QV-TVGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVTSKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRQS-------G-
--------------------SRGG--GGGGGS----------------------------
----ISGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--I-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSSEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSY----RAGS------------------------------
-----------------------------------KGL-SGAFGSRSLYGLG-GT----R
NISFNVVSG--NGK-NG------------------------GY-----------------
------------------------------------------------------GFGRGR
SSGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------I-NE-S
L--LAP-LN-VE-LD-LE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDV---NN--CRNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDLVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QETKFLRCLFEAEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRSLDL--------DSIIDEVR-VQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNMET----AI
ADAEQRGDKALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------SM-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGDSRSR-GSVS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARSRG----RS-RGGFSS---RGGFSSRSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-WS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYEEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYLYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
PQLHQEIQRLQSQ--I---------ENLKKQ-----------------NATLQA----AI
TDAEQRGELALKDAQAKVDEL---------------EAALRTAKQNLARL-------LC-
------EYQELMSTK-------------------------------L-SLDVEIATYCRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVMSGGVGGGL-GSICGLGSGKGSPGS-CCTSIV
TGGSNIILGSG---------------------KDPVLDSCSVSGSSAGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSVCRSG------------------------------RGFSSGS--
AGLVSF------QRRSTSGSV----RRSGGGGGG--------------------------
---------RFSG-------GFCRSG-------GA----GGGFGSQSLVNLG-GG----R
SISMSVARGGR--SSFGGGSFGGG--SG---------------GFGGG------------
-SFGGGGG---G----F-G-------G-GFGSGG--LGGGGFGGGGFGS---GGGFG-GG
--GY-G-----GGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SH-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTYSLEPLFESYISSLRSH----VDQLKSDQ
-----------TRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQAKVDNLQ---KDIDFFTALYQAELS-QM-QTHISETNVIL-
-SMD-------------------NNRSLDL--------DGIIAEV-KAQYDSIAQRSKDE
AETFYQS---------K----YEEL-QI-TAGRHGD-SVKSSKM--------------EI
SELNRMIQRLRSE--I---------DSVKKQ-----------------IAQLQQ----NI
SDAEQRGENALKDAQNKLNEL---------------EDAMTQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECT--ANVS---------VSVSTSHT------------
---------------------------------------SMSGGSSRS--G---------
-------------------------GGY--------GSG-GGGYGSGGGGSY-----SG-
--------G--------G------------------------------------------
--------SYGSGG-GGGGGGYGKAGGSSGGHRGGSGVGGG-------SSGGRGSGGG--
------SSGGSYSSSGAQGSS-----------------------------------SGGV
K----SSGGSSSV-------KFIST-SYSR------------------------------
------------------------------------------------------------
--------------------GTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGG------------------------------DKGGFSGHS--
AAVL-RK-------ALGSAASY----RAAG------------------------------
-----------------------------------KGA-GAGFGSRSLHTLGR-N----Q
CVCFNAASS--GVW-TG------------------------GHSFGLG------------
-----------------------------------------------------SGYAGGR
ASGFAGSMFGSMALG-PM---YP----SMCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-QL-LQQLDL---DN--CKKNLEPILEGYISTLQKQ----LEALSGDR
-----------MRLDS-----ELKIMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QV-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQSK-------------IQEL-QL-AAGQHGD-DLKHTR--------------NEI
SELNRLIQRIRCE--I---------ANVKK-----------------QCSNLET----AI
ADAEQRGENALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSA------------
------------------------------------------------------------
-----------------------------------------SGYG-YHP---------G-
-----------------SL-------ASSDPGA---------------------------
----STVA-------------------------------------------SSSGSTR--
--------SGQTRAKVTQAG-----DPK-------DPQ---SKS------AP--VSGPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSRS----------------------------RRVYSGGS--
---------------------------SVGS-GGG-------------------------
---------SRAVRSVCQARGRCSSG-G-----GGYGSHARGFTSRSLYNLG-GS----K
SISISLVGRSASG--FCQGGGA-------------------GGGFG------------G-
RSF---------------------GGG--------GFGGRGFGGGGYG----GGGLGGAG
--FR-GGNLGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-MR-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--QTNNLEPVFESYIIKLQRQ----VDFLRAEQ
-----------MRQSS-----EIRSMQDVVDDYKN--KYEEEINRRTSSE--NDF-VVLK
KDVDS----AYL-SKVDLQSKADTLL---EEVDFLKYLFQSELS-QM-QTNITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RIQYEEIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-ELQTSRM--------------EI
SELNLTIQRLQAE--I---------GNVKKQ-----------------IEQMHT----II
SDAEERGQQALQDAQQKLQDL---------------EAALQQSKEELARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------ISVQ----------------
-------SSQ----------------------------LTIGGGARGSGGY-----SGGG
-------------------------------------------GYAG---GGGGYAGGGS
S-------------G---------------------------------------------
--------------GYGGGGSRGGSGGYGGGSR-GGSGG-------------------GY
G-----SGSGS-SGGSSKSS----------------------------------SKHG--
G----GSGGASRM-------QIIQT-STS-------------------------------
---------------------------------------------------------TSR
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLS-VKSGG------------------------------NKGSFSVHS--
AVVP-RK-------AVGSLSSH----RAAG------------------------------
-----------------------------------RGA-GPGFGSRSLYNFG-GN----R
HVSFNVAVS--GLR-AG------------------------GYGFGHG------------
-----------------------------------------------------AGYGGGR
ASGFAGSMFGSMALG-PV---CP----SMCP-P-GG-I-HQ-VT----------V-NK-N
L--LAP-LT-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CTKNLEPILEGYITSLQKQ----LEALAGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RFEVEINQRTAAE--NEF-VVLK
KDVDA----AYA-GKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVC-VHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTK--------------GEM
SELSRLIQRIRGE--V---------GNVRKQVGSDPTRSPEAWWCPLG-TSRKT----AI
ADAEQRGDCALRDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGDNPSSVS-----------ISVISN--------------
------------------------------------------------------------
-----------------------------------------STYS-FHP-----------
-----------------S--------SVANLRT---------------------------
----SSVV-------------------------------------------GSSSSAR--
--------SRQTKTKGGRGG-----DLK-------DSQ---DKS------VP--ARAPAR
-KATH-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLAHY-AGG------------------------------ERPGFSGCS--
AVLS-GR-------LSCSSASF----RA-G------------------------------
----------------------------------VK--GSAAFGSKSVFCLG-GG----R
RLALSA-----AGR----------------------------------------------
--------------------------------------------------------SGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRNNLEPIYEGYVSNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYDVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKIELQAKVDSLT---DEIKFFKCLYEGEIT-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQTK-------------IQEL-QV-TAGRHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADAEQQGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTGA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAA--GGYS-YKPA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPL---AKT-------S--GSSCAT
KKAPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSTFSGA-----------RG---RAGFSSRSLSSSR-KC----R
G-SS-GG-----------------------------------------------------
-----RAWGAEA--R-QG-V---------------------------------R-F-V--
-------Q-RS-G-G-PG-L-S-----Q-CP-P-GG-I-QA-V---------T-VN-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGSHSPQGLEHIFEACLARLRQQ----LEELQRER
-----------GALDS-----ELKTYQDQEEEFKS--KYDQEAHKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGKLESLR---EYICFLTRLYEEELR-QL-QTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RAQYEEITRTSKAE
AEAVFQT---------K----YQEL-QA-SAQLQGD-NIKEARM-------------Q-I
SQLRQAVQRLQSQ--I---------ASLKKQ-----------------NDSVQS----AI
ADAEQQGEMTLRDAKAKLDEL---------------EDALRMTKQDMAQM-------LR-
------EYQELMGTK-------------------------------L-SLDVEIATYRRL
LESEECR------------MSKEYISQVTVS----------------T--AEG-------
------------------------------------------------------------
----------------SVVP--------GGVCGGQVII-------PGRTGGGQ-----MI
VPGRTGG----------GQVVIPGGD----------------------------------
--------------------------------------HRGQMVV---------------
---------------------------------------------------PGRVDGG--
---------QMVVPGRVPGGV---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------G---DDQVGTCDLRGWKGSFGSGGCSSIV
TGGFDIPHGSG---------------------RSPSMGSCSVSGSGFSSGS--GSCCRTI
LKKTVESSRKTSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCRSRRGGGG--GGGG---------------------GFRGFSSGS--
AVVSGG------SRRSNTSFSC--ISRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISSSVAGNSGG--YGG------S-SFGG------------SSGFGGGRGFGGGQGFGGS
GGFGGG----SG----FGGG-QGFGGGSRFGG-GSGFGGGGFGGGSFGG----GRFGGGP
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LRT-KW-EL-LQQLDV---GS--RTTNLDPIFQAYIGMLKKQ----VDRLSAER
-----------TSQES-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NDF-VTIK
KDVDS----CYM-DKTELQARLDILA---QEVNFLRTLYDAELS-QL-QQDVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QNQYEMIAHKSKAE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKGVQD----SI
ADAEQRGEHAIKDARGKLTDL---------------EEALQQCREDLARL-------LR-
------DYQELMNTK-------------------------------L-SLDVEIATYRKL
LEGEECR------------MSGDFS--DNVS---------VSIT----------------
-------SST----------------------------ISSSVASKTGFGSGGQS--SGG
RGS---Y-GGR---------------------GGG-GGG-GSTYGSGGRSSG------SR
G-SGSGSG-GGGYSSGGGS--RGG--SGGGYGSGG-------------------------
---------GSRG-------GSGGGYGSGGGS-----GSGGGYSSGGGSRGGSGG--GGV
SSGGGSRGGSSSGGGS----------------------------RGG-----SSSG----
-----------------------------------GGGYSSGGGSRGGSS------SGGA
GSSSEKGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PRG------------------------------ERLGFSGYS--
AVLS-GR-------IGSSSASF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LS-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLQKQ----LEMLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDMDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIT-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNLLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGHCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------L--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSMK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQITIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVMSGGVGGDL-GSICGLSGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRPFSSRSG----YQ--------------------------SKGCFSSGS--
VGAISC------QRRSTSSSM---RRSGGGGGRF--------------------------
-----------SG-------GFCGG--------AGGGGGGGGFGSRSLHGFG-ST----K
RISMSMSGGG--RGG-----------------------------FGGGYG-------GGG
FGGGGFG-GG-------GMG-GGFGMSGGFG-------GG------------------GG
--GFGSGGGFGGGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-VD-PE-IQ-KIK-SE-E------------------------------
------R-EQI-KS-LN-NQ-FA-SLI-DK-VKF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQVDT---TT--RTQSLEPLFEQFIMNLKAL----VDKLKRER
-----------SQMDS-----ELKHNQDLVEEYRN--KYEEVINKRTNAE--NEF-VTIK
KDVDS----AYL-VKVDLQAKVNLLL---EEINFFQT-----------------------
-----------------------------------------------AEYEAITQRSKAE
AETWYQN---------K----YEEL-QV-TAGKHGD-SLRTTKM--------------EI
SELNRMIQRLRSE--I---------DSVKKQ-----------------ISQIQQ----SI
SEAEQRGEKALKDAQNKLNEL---------------EEALQKAKEDMTRL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEEVR------------MSGECP--PQVS---------VSVS----------------
-------TSH----------------------------ISASGSSSRGGGGG--------
--------------------------------------------------GY------SY
G-GSGGGG-GGGYGSGGRGSSSGG-DSH-------------------------------S
SGGGGSYGSGGSSGGHRGGSGKGGGRGSGGGSSGGGSS-------GGGYGSGGYGS----
-------------SSGGTKTSSGGSSVTFV----STSYSRGTK-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAV------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-NGGFGSRSLYSLG-GA----R
SISLNVASG--SGK-SG------------------------GF-----------------
------------------------------------------------------GFGRNR
PSGFAGSIFGSVALG-PV---CQ----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLDL---NN--CKNNLEPIHEGYISNLRKQ----LETLSGDK
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---EEIKFLKGLYEIELS-EI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-TQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRLIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGS--SG-LRP-----------
-----------------NT-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-SSAS-----DYK-------DTL---GKG-------S--SPSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-MS-----SKSTM--I----------------------------------RHGFSTSS--
ARVPGT----C--RS---GFSSISMSRSRGSGGL--------------------------
----------------------------------GGACGGAGFGSRSLYGLG-GP----Q
R-ISVGGSSCTMRSGYG-------------GRLGGGFG------FGGA--------AGS-
----GFGFGGGAGGG-FGLGG-G----A-------------------------------G
---LGGGYGGS----------GF----PVCP-P-GG-I-QE-VT----------IN-Q-S
L--LTP-LN-LQ-ID-PT-IQ-RVK-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LDT-KW-TL-LQEQGT---KT--VRQNLEPLFEQYINNLRT----QLDSILGER
-----------GRLDS-----ELRGMQDLVEDFKN--XXXXXXXXXXXXX--XXX-XXXX
XXXXXX----XX-XXXXXXXXXXXXX---XXXXXXXXXXXXXLS-QM-QTHISDTSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQRSRAE
AEAWYQT-------------KYEEL-QV-SAGRHGD-DLRNTKQ--------------EI
SELNRMIQRLRSE--I---------DHVKKQ-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXX-------XX-
------XXXXXXXXX-------------------------------X-XXXXXXXXXXXX
XXXXXXX------------XXXX------------------------X--XXXXXXX---
------------------------------------------------------------
----------------------------------XXXXXX-X--XXXXXXXXX-----XX
---------------------------------XXXXX----------------------
---XXXX--XXXXXXXXXXX--------------------XXXXXXX-------------
-----------------XXX--X-XGL--------SSS----------------------
-----------------------------------------------G-GS---------
---------------------------------------------------------SST
IKYTT----TSSSSRKSFKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLT--H----------------------------------Y---------
-------------QG---GE----RLGFR-------------------------------
-----------DCSALFWA-RFCSS-----SVSFKRVKGLRALRGRNLFYLG-GS----E
PVLRA-------------------------------------------------------
--------------------------EAKWG------------G---------ECLG--G
---FGVSVFGSAKLG--K---AC----QSET-P-GG-L-PQ-VP----------DN-K-S
S--LTP-FN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--SRNSLEHVYESYASSLRKT----LETLSGDR
-----------VRLDS-----ELRSMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEV-RAQYEEIALKSKAE
AEALYQT-------------KIQEL-QV-TAGQHGD-DLKLTKA--------------EI
SELNRLIQRIRSE--I---------GNVKKQ-----------------XXXXXX----XX
XXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXX-------X-XX-XX-
-----X-XX-XX-XX--------------XX-X-------------X-X---XXXXXXXX
XXXXXXX------------XXXX------------------------X--XXXXXXXX--
------------------------------------------------------------
-----------------------------------XXXVI-SSTNAGAGGTGF-----SV
GFGAS-G-----------S------Y-SCKPAAGDV------------------------
--------------------KTKG--------------------SCGS------------
--------------E------------------FKDPL---SK-----------AS----
-------------------------------------G---------NSCA---------
---------------------------------------------------------TK-
----------KAS-R---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------RYEEEINRRTAAE--NEF-VVLK
KDVDC----AYM-TKVELEAKVGALT---DEINFLRCIYEEELA-QL-SAQVSDTAVIL-
-SMD-------------------NNRDLDL--------SSIIAEVK-SQYEDIANRSRAE
AEAWYQTK-------------YEEL-QA-TAGKHGD-DLRNTK--------------GEI
SELNRLIQRIRAE--I---------ENTRNQ-----------------CATLQT----AI
GDSEERGELALKDAKAKMTEL---------------EDALQKAKADMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEESR-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSL----CWAQR---GFSARSA-----------------------------------
----------------SCAPVGT-----------RG---RGGFSSRSFGSFG-GS----R
G-GC-RG-----------------------------------------------------
-----RTWGSGA--R-LG-L---------------------------------Q-F-G--
-------Q-GR-G-G-AG-L-S-----L-CP-V-GG-I-RE-V---------T-VN-Q-N
L-L-AP-LK-IS-VD-PQ-FQ-AVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-AL-LQQ--L---GVSDGPRDLQPIFEAYLAQLRGQ----LEQVQRAR
-----------GALDA-----ELKTCQDQEEEYKA--KYEEEARELATAE--NDF-VVLK
KDVDA----VFL-SKMELEGKLEALR---GHLSFLRRLYEEELG-QF-QGQGSDASVVL-
-SMD-------------------NSRSLDF--------SDIIAEV-RARYEDIARSSKAE
AQALYQT---------K----YQEL-QA-SAELRGD-SMKAAKA-------------Q-L
SQLQRAVQQLQSQ--I---------ENLKKQ-----------------NSNLET----AM
ADAEQRGELALRDAQAKLDGL---------------EGALRSAKQDLARL-------LR-
------EYQELMSVK-------------------------------L-ALDVEIATYRRL
LEGEESR------------MSGECPSQVVIA----------------T--VGGSA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TVPGGT-GGGVAGACGFGDGRGSSGS-GCSSIV
TGGASVTLGSG---------------------QGPVWGSCSVSGSGSVSGSGSGSSSRTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPASA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-GGGFSSRSLFSLG-GA----R
SISLNMASG--KSG-SY-------------------------------------------
------------------------------------------------------GYARNR
PSGFAGSMFGSVALA-PV---CS----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LH-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPIFEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFRCLYEGEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIAEIR-TQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRVIQRLRSD--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARTKLDEL---------------ESALHQAKEELARM-------MR-
------DYQELMSVK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPSA----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGEARSR-AGAS-----DYK-------ETL---GKA-------S--SLSTPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLY-PGA------------------------------ERLGFSGCS--
AVIS-GR-------FSSSHASV----RA-G------------------------------
----------------------------------VK--GA-AFGSKSLFCMG-GG----R
RLALSS-----AGR-SG------------------------GFALGHG------------
------------------------------------------------------GASSGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-LE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKRSLEPVYESYISNLQKQ----LEILSGDR
-----------VRLDS-----ELRNMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVDLQAKVDSLT---SDIKFFKVLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRQLDL--------DSILTEVR-AQYEEIAVKSKAE
TENMYQCK-------------IQEL-QA-TVGQHGD-DLKLTK--------------TEI
TEINRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------MR-
------EHQELMNVK-------------------------------L-ALDMEIATYRKL
LESEESR------------MNGDYSHSVS-----------ICKYHMSFA---P-------
-------------------------------------------SQGHR------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSMS----------------------------RQVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYARGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISINLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RGFGV-----------GS-----TGAG--------GFGGG-----GFG----GGGFGGAG
--FG-TSNFGLGGIG------------PYC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRRQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSVSGGAGGGGSY-----GSGG
-------------------------------------------YGSG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---GG------GGSGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHHFSSQSTFSLRS----------------------------RQACNNTS--
---------------------------SSGF-GGG-------------------------
---------SRVVGSVSQAWGRDGS--------GGYVGHGRGFGSRSLCSLR-GC----T
SISSGLVGRSASG--FHQGRGA-------------------GGRFR------------VG
RSFGGCGLGSGS------------------------FGTGRFGGG----------LGV--
--AG-AINFGSAGFG------------PSY-SP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-KSK-TR-E------------------------------
------R-EQL-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---LS--QTNSLDDFFENYISTLQKQ----ADFLNAEQ
-----------MHINS-----EIGSMEDIVEDYKS--KYEEEINKRTNIE--NEF-ADLK
KDMDA----ACM-SERNLQSKLHILI---VEINFLKYLCGVEMS-QV-QTNVTDTNVIL-
-SMD-------------------NNRTLDL--------DSIIQAV-QAEYELIIQKSKDE
AEALYQT---------K----YQEL-QI-LAGRHGD-DLKNTKM--------------AI
AELNRNIKGMQAE--I---------ANVKKQ-----------------IEQMHS----AI
SDAEERGDRALQDAKQKLQNM---------------DEALQNSKEDLARL-------LC-
------DYQAMLGAK-------------------------------L-SLDVEIATYCKL
LECEENR------------MSGEQQSHV--S---------IAVQ----------------
-------SSQ----------------------------VAVSGDGGGGG-S-----R--G
-------------------------------------------YRGG--YPSSSSSGGSF
G-----------------------------------------------------------
----------------------------------------------------------GS
GR---SGSSGS-YGANTR-S--------------SSR-----------------S--GSR
A----GGSSSRRV-------QIIQT-STI-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARSRG----RS-RGGFSS---RGGFSSRSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-WS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYEEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLEALR---EYLYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARSSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SQLHQEIQRLQSQ--T---------ENLKKQ-----------------NASLQA----AI
TDAEQRGELALKDAQAKVDEL---------------EAALRMAKQNLARL-------LC-
------EYQELTSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECTSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVMSGGVGGGL-GSTCGLGSGKGSPGS-CCTSIV
TGGSNIILGSG---------------------KDPVLDSCSVSGSSAGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGQGR
ASGFAGSMFGSVALG-SV---CP----SLCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKADALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------MAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFR-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PRR------------------------------ERLGFSGCS--
TVLS-GG-------IGSSSASF----LA-G------------------------------
----------------------------------VK--GSASFGSKSLSCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---NN--CRKNLEPIYEGYISNLQKQ----LEMLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIT-QI-QSHISDTSIVL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEVTLKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELVSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRSQR---GFSTRSA-----------------------------------
----------------CSALSGG-----------HG---RGSFSSRSLSSFR-GC----R
G-GS-RG-----------------------------------------------------
-----RAWVSRG--R-LG-M---------------------------------R-S-G--
-------E-GT-G-G-PG-L-S-----L-CP-P-GG-I-RE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVK-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--L---EVSDSPQGLESVFEAYLAQLREQ----VEQLQRER
-----------WTLDA-----ELTAFQKQEEEYKA--KYELEAHRHATVE--NDF-AVLK
KETDG----AFW-SKMELEGKLEGLR---EFFCFLTRLYEEERS-QL-QTQVGDTSVVV-
-SMD-------------------NNRCLDF--------SDIIDEV-RARYEEIACTSKAE
AEALYQT---------K----YQEL-QS-SAQLHGD-SMKETKI-------------Q-I
SQLQHEIQKLQSQ--I---------ANLKGQ-----------------NADMQS----AI
SDAEQHGELALKDAKSKLDEL---------------EGALRMAKQDMARL-------LR-
------DYQELMSTK-------------------------------L-SLDVEIAMYRRL
LEGEECR------------MSGECTGQVIIS----------------T--VGD-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NAIVPGGVGGSR-GGTCGFRGRKGSFGS-GCSSVV
TGGFNNTLGSG---------------------QGPTSSSCSMSGSGFSSGSSSSSSHHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISFNVAGG--TGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQAKDELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGDSRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLF-TGG------------------------------ERLGFSGYS--
AVLS-GR-------FGSSCSSF----RT-G------------------------------
----------------------------------VK--GAAPFGSRSLFSLG-GG----R
RQARCCA-G--SGR-GG------------------------GFALGHG------------
------------------------------------------------------GAGGGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-VE-LD-RE-IQ-KMR-VQ-EREQIKALNNKFASFI---------------
----------------------------DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CGKRLEPIYEGHISSLRKQ----LETLSGDR
-----------VRLES-----ELRNMKDIVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKIELQTKVDSLT---EDIKFFKCLYEEEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRELDL--------DSIIDEVR-VQYEEIMQKSKAE
AECLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SEVNRLIQRLHSE--I---------GNVKKQ-----------------CSNLEV----SI
ADTEQRGDCALKDARAKLHEL---------------EGALQQGKEELARL-------LL-
------EYQDLLNTK-------------------------------L-ELDIEIATYRKL
LESEESR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------TGGAGFNVG--------
-----------------------------------FGAS--SSYS-YKGA--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------DC--VS-----ELK-------DPL---GKT-------S--GSSCTT
KKVSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PGG------------------------------ERLGFSGCS--
AVLS-GR-------IGSSSTSF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-SE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GGSCAT
RKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--MSSTTMRSQCS--S----------------------------------RRGFSASS--
ARVPGV----C--RS---GFSSVSVSRSRGSGGL--------------------------
----------------------------------GGVCGGAGFGSRSLYGLG-GS----K
R-ISIGGGSCAISGGYG-------------SRVGGGFG------FGAG--------AGS-
----GFGFGGAAGSG-FGLGG-G----A-------------------------------G
---FAGGYGGS----------GF----PVCP-P-GG-I-QE-VT----------IN-Q-N
L--LTP-LN-LQ-ID-PT-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-----------XXXXX-----XXXXXXXXXXX------YEDEINKRTTAE--NEF-VTLK
KDVDA----AYM-NKVELQAKVDALM---DEINFTRAFYEAELA-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT-------------KYEEL-QL-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CASLQA----AI
ADAEQRGELALKDAKNKLAGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LSGE------------------------G--VGPVNIS---
------------------------------------------------------------
----------------------------------VVQSTI-S--GGYGSASGV-----GS
---------------------------------GLGLG----------------------
---GGSG--YAYGGSHSLGG--------------------GFSSGSG-------------
-----------------RGV--G-SGL--------SSA----------------------
-----------------------------------------------G-GS---------
---------------------------------------------------------SST
IKYTT----TSSSSRKSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRQSCGLN-----------------------------------KGFSSSS--
ACLGG-----------------------------G-------------------------
---------RNKV-------SFSSV--------ARGGCRGSGGNSRSLYSLG-GS----K
STSLGGFGGAGACRGFGAGGQGGF-GYGL----------GAGAGFGG----------G--
F----GG-GG-------GV---GFGGGAGVG-------FGG--G--LGG-----GFGGFG
---GGFDGGIGGQGF------------PAC-PP-GG-I-RE-VT----------IN-Q-S
L--LAP-LN-LE-ID-PE-IQ-KVR-TQ-E------------------------------
------R-EEL-KT-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-KL-LQEQSP---STGG--RSLDPYFEAYISGLRQQ----LDGLSSEK
-----------HQLEL-----ELKSFQDMVEEFKT--KYEEEINKRTTAE--NDF-VLLK
KDVDA----AYM-TKVELQAKLDSLA---DEVNFMRSLYEAELS-QM-QKTVSDTSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIANRSRVE
AETWYQS---------K----YEEL-QV-TAGKHGD-SLKDTKA--------------EI
SELNRTIQRIRAE--I---------ESVKKQ-----------------CETVQS----SI
ADAEQRGELAIKDAKAKLTEL---------------ETALKKAKGDLAQQ-------MR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGECQ--SSVS---------IS------------------
-------VVG----------------------------GSSSVGGGYG------------
--GSSGVYR-------------------------------------GCYGGG------AY
G-GRMGGF-GGG------------------------YGGGL------------GSYGGGM
GG----------FGGMGGGMGGG------------GMG-------GGGFGGGSSGGSCGM
G--G----GM--YS----------GGFSSG----SGRM--------------CASGGGNF
S----SGGGSSSV--RR----CVTT-TSVKSSGVR-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGVA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-SP----R
SISFNVASS--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGSGALG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--CRRNLEPVYEAHISSLQKQ----LDSLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIT-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------ERALHQAKEELARM-------LR-
------EHQELMSMK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSAVS-----------ISVISSSAP---G-------
---------------------------------------------TVGAGTS--------
-----------------------------------FGFSSAGTYG-YRQ-----------
-----------------SS-------VAGGYGI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-DTKNRLGSAS-----EFK-------EVS---GKT-------L--ALGSPS
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFSSRS----------------------------RRLYSVGS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCQARGRCGS--------GGYGSIAKGFGSRSLYNLG-GS----K
SNSINLVGRNTSG--FCQGGRA-------------------GGGFG------------GS
RSFGGG----------GG-----FGGG--------GFGSG-----GYG----GGGFGGAG
--FG-GSNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-AQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTNNLEPVLEKYISKLRRQ----VDFLNAEQ
-----------MRQNT-----EIRSMQDVVEDYKN--RYEEEINRRTSTE--NDF-VVLK
KDADA----AYM-SKVDLQSKMDVLF---GEVNFLKYLFQTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQKSKEE
AEALYQT---------K----YQEL-QI-TVGRHGD-ELKNSKV--------------EI
TELNRTIQRLQAE--I---------SNIKKQ-----------------IDQMHM----AI
SDAEERGEQALQDARQKMQNL---------------EEALQQAKEELARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------SSQ----------------------------VSISGGGGGG-GR-----GSGG
-------------------------------------------YCGGG-GG-----SSSS
R-------------G---------------------------------------------
---------------GYG------GRGYGGGSR-GG-----------------------Y
GSG---SGGGS-YGGS--------------------------------------SKFRGR
I----SGVS-SHV-------QIVQT-STN-------------------------------
---------------------------------------------------------TSH
KRVLE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SRQFSSRSFSTGGR---------------------------RGYSFPGSG--
FRV-------------------------------G-------------------------
---------NGST-------SLVPV--------GGVGASSGGFGSRSLHSLG-GS----K
KISMGIVSGGGGSGGYFAGGVGGR-NLGS------G---LGFSSFSTGYG---------G
L----------------GSG-VGFGGGACLG-------GGVALGSGVGQ---GGPAGGFG
-----GGGYGLSGPG------------PLP-AP-GR-I-HN-VV----------VN-K-N
L--LAP-LR-VE-VD-PD-IQ-RVR-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-TFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-DL-LYQQGT---PA--LRDNLEPLYEAYIDTLRRQ----FESLTNDK
-----------NHLDI-----ELKNTQELVEDFKS--KYEDEINKRTACE--NDF-VVLK
KDVDG----SYM-HKIDLGSKADSLT---QHIQFLRALFETELS-QV-QSQVRDTNVVL-
-QMD-------------------NNRDLDL--------NGIIAEV-RAQYEDIANRSRAE
AETWYQS---------K----YQEL-QT-TAQKHCD-ELKTTKD--------------DI
AEMSRVVHKLRAE--I---------EIVKKA-----------------VNGLQS----SI
AESEQRGEIALKDAQKKLLDL---------------QSALTSSKDELARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRTL
LEGEESR------------MSGECP--TPVN---------ISVI----------------
-------SSS----------------------------STISGGGGGV----G-YSGGSG
-------------------------------------------YGIGGGSGM------SL
G-GGGGGY-GVGGGSG-------L------------------------------SLGGGG
GGYGVGGGSGLSLGGGGGGYGVGG--GS----------------------GLSLGGGGGS
GHINTGGGKISRFSSGGSLSG-------------SGNI-----------------ASGGY
S----YGGSSSSI--K-----ILPT-TSTFSR-ISS------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSAFSGV-----------RG---RASFSSRSLSSSR-GC----R
G-SS-CG-----------------------------------------------------
-----RAWGVRG--R-QG-V---------------------------------R-C-G--
-------Q-GS-G-G-LG-L-S-----Q-CP-P-GG-I-QE-V---------T-VD-Q-S
L-L-TP-LK-IE-ID-PQ-FQ-VVK-TQ-E------------------------------
------TR-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGSPSPQGPEPIFETCLARLRQQ----LEQLQRER
-----------RALDT-----ELKTYQDQEEEYKR--SEA---------Y--MTP-VFLS
QDVDE----VFL-SKMDLGGKLESLR---EYVCFLKRLYEEELG-QL-QTQADDMSVVL-
-SMD-------------------NNRCLDF--------SAIIAEV-RARYEEIAQTSKAE
AKALFQT---------K----YQEL-QS-SVQLHGD-GMKEAQR-------------Q-I
SELQQVMQRLQSQ--I---------SSLKGQ-----------------NASLQS----AI
SDAEQHGEMALKDAQAKLDEL---------------EDALRTAKQDMARM-------LR-
------EYQELMGTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------ISGEYTSQVTVC----------------E--YGGTFRA---
---GSPCGAEDP--------------AVTLVHF-------LA-ATMGGTTG---------
GVCG----------GQVIMP--------RRVCGGQVVL-------PGGVGGGQ-----IT
RPGGVCG----------GQITRPGGVGGGQITM---------------------------
----------------------------------PGGVGGGQITRPGGVCGGQITMPGGV
GGG-------Q-IASPGGVG--G-GQITIPEGVCGDQITRPGEVSGGQITMPGGVGGGQI
TRPGGVCGGQTTMPGGVGGGQIA-----------RPGGVGGGQITR-----------PGG
VCGGQTTMPGGVGGCQIARPGGVCGGQITGPGGVGGGQIARPGGVGGGQITMPGGVGGQI
VRPVGVG------------------------------------GGQIARPVGVGGGQIAM
PGGVGGGQIAR-----------P-GGVGGQIVRPGGVGGEQITMPGGVGGCQITMPGG-V
GGQIVRPGGVGGGQIARPGGVCGGQITGPGGVGGGQIARPGGVGGGQITGPGGVCGGQIT
MPGGVGGGQITMP------------GGVGGQIVRPGGVCGEQITMPGGVGGGQITMSGGV
CGG-----------QITMPGGAG-GGQVIPGGAG-GGQMNTCGFGGRRGRFES-GCSSIV
TGGFNIPWRSGN--------------------NSSGLGSCSVSGSGFSSGSGCGSCCHTI
LKKTEESRWKTSIIH---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCRISSRSR---GR--GGGG---------------------GFRGFSSSS--
AVGSGG------SRRSTSSFSC--LSRHGGGG----------------------------
-----------------------------------RGVGGGGFGSRSLVGLG-GS----K
SISISVAGGGGSFGSGGGFGGRGG-GFGG------------GSGFGGGI------GFG--
-GG------------------SGFGGG-------IGFGGGGFGGGGFGG----GRFGGGG
--GFGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VG-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVHV---GT--RTSNLEPIFQAFIAQLKRQ----VDTLCAER
-----------TSQDS-----ELNSMQDLVEDFKK--KYEDEINRRTAAE--NDF-VTLK
KDVDN----AYK-VKVDLQAKVDVLT---QELEFLRILYDAELS-QM-QQSVTDMSVVL-
-SMD-------------------NNRHLDL--------DSIIAEV-RAQYEEIALKSKAE
AEALYHSKA-------R----YEEL-QV-TAGKHGD-SLKEIKV--------------EI
SELNRVIQRLKGE--I---------AHVKKQ-----------------CKSVQE----AI
ADAEQRGENALKDAQHKLSEL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVAAKAGF-GG-YG--SGS
RGS---S--SG---------------------GGRYSSG-SGAYSSGGRASS------SR
G-G--S-G--GG---GSGS--GGG------------------------------------
-------------------------YGSGGGS----------------------------
---------------RG--------G---------------------------S------
-------------------------------------------------S------SGR-
----------GGS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAV------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAAG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GP----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGNVALG-SM---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLMQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------AAGTGAG--------
-----------------------------------FGFSNAGAYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAI------------------------------TKGGFSGCS--
AVLS-GG-------S---SSSY----QAGV------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SIPFNVASG--PGR-AV------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGNVTLG-PS---SP----SMYL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKKLEPIYEGHISGLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDMVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDSLE---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------GEI
SELTRLVQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LC-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGAVAG--------
-----------------------------------FGFGGTGTYG-FRP-----------
-----------------SS-------VSGAYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DVQ---GKT-------S--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PGG------------------------------ERLGFSGCS--
AVLS-GR-------IGGSSASF----RA-G------------------------------
----------------------------------VK--GTASFGSKSLFCLG-GS----R
RLALSAV----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LDT-KW-DL-LQQLDL---NN--CRNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDLVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNSLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFTTG--------
-----------------------------------FGAS--SSSS-YKTA--------A-
-----------------AD-------LKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGESALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGGGG-G------
---------------GRGS-----------YG----------------------------
-S---GGGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSSGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQYSSQSAFSSRS----------------------------RQVYRTSF--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYTRGRCGG--------GGYGIRGRRFGSRSLYNLG-GS----R
SISISLVGRSASG--FCQGGGV-------------------G-GFG------------GV
RSFGV-----------GS-----IGAG--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRKQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYA-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEES------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------WRVYSAGS--
---------------------------GGG------------------------------
---------S---RAVCQSRGRCGGS--------GYASYGKGFGSRSLYNLG-GS----K
SIFISLVGRSASG--FPQGGGA-------------------GEAFG------------WG
RSWFG-------------------------------------------------------
-----GSNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-DQI-MA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RSSNLEPFLECYISDLRRQ----VDFLKAEQ
-----------MRQDT-----EVRNIQDILEDYTN--KYEEEINRRTSAE--NDF-VVLK
KEVDS----AYE-IKVDLQSKVDTLF---GETNLLKCLYETELS-QM-QTHISDTNVIL-
-SMD-------------------NSRSLDL--------DSIISGV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKV--------------KI
AELNLNIQRLQAE--I---------ANVKKQ-----------------IEQMHS----AI
SDAEERGQRALQDARQKLQDV---------------EQALQQSKEELAQL-------LR-
------DYQELLGVK-------------------------------L-SLDVEIATYCKL
LEGEESR------------MSGDLQSQV--S---------ISVQ----------------
-------TSQ----------------------------VTVSGSGGGSGGS-----YGGG
----------------------------------------------------------SS
R-------------V---------------------------------------------
----------------------GGEGNYGAGTR-GVSGG-------------------GY
GTT----AGAS-YRGSSK-S--------------------------------------RN
K----YGGSSSRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSY
KHTVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACRDQEEEYKF--EYEEEAHRRATLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SVD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQITIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGDL-GSICGLSGGKSSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-XXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXELS-QM-QTHVSDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
SEINRMIQRLRSE--I---------DHVKKQ-----------------CTNLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------ISVT----------------
-------QST----------------------------VSSGYGGAS--GV---------
---G-----------------------------G--------------------------
------------------G--------------------------------------LGL
G------------------GGSGYSYGSG--LGV----GA-GF---------SSSSGR--
---------------------------VI---------------------------GGGL
S----SVGGGSST--I----KYTTS-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGG------------------------------DKGGFSGHS--
AVVL-RK-------VGGSAASY----RAPS------------------------------
-----------------------------------KGA-GAAFGSRSLYSLCRGD----L
CVPLKVAGS--SVR-TG------------------------GYNFRLG------------
-----------------------------------------------------SGYGGVR
ASSFAGSMFGSVVLG-PV---CP----SMCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-MA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQMDL---NN--CRKNLEPILEGYIGNLRKQ----LEMLSGDR
-----------LRLDS-----ELKGMRDLVEDYKK--RYEVEINQRTAAE--NDF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDIKFLKCLYDAEVA-QI-QTHTSETSVIL-
-SMD-------------------NNRYLDL--------DSIIAEVR-AQYEDIALKSKAE
AEALYQSK-------------IQEL-QL-AAGRHGD-DLKHTK--------------NEM
SELNRLIQRIRCE--I---------ANVKKQAFSVC---SKPAPCPLQCANLET----AI
ADAEQRGDSALKDARAKLDEL---------------EAAMHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYSKL
LEGEECW------------MSGENPSSVS-----------ISVISSSA------------
------------------------------------------------------------
-----------------------------------------SSFG-YHP---------G-
-----------------SS-------ASTDLGA---------------------------
----STMAST-----------------------------------GT----SSSSSTQ--
--------SGQTRAKGARVG-----DPK-------DSQ---DKS------TP--VSSRAR
-KAAR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G-----GSFGAGGGFGSRS-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------L-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDG----AYM-TKVDLQQEIDFLTTLYQAVKSLTYYVLQELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVRNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGWRPR--R---------
---------------WRRVAMALEVAAM--------APG-GGSYGSGGGGGG-G----R-
---GSYGSGGGS------------------YG----------------------------
-S---GGGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SFGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAWR---GFSARSA-----------------------------------
----------------CSARSRG-----------RG---RGGFSSRNLNSSR-GC----R
G-GS-LE-----------------------------------------------------
-----RAWGSRG--R-LG-V---------------------------------W-F-G--
-------E-DS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-D
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--L---GVSDSSQGLESFFEAYLAQLRKQ----LEELQRQR
-----------GALDA-----ELKSCQNQEEEYKA--XXXXXXXXXXXXX--XXX-XXXX
XXXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXXXX-XX-XXXXX-XXXXX-
-XXX-------------------XXXXXXX--------XXXXXXXXXXXXXXXXXXXXXX
XXXXXXX---------X---XXXXX-XX-SAQLHGD-CMKETKV-------------Q-I
SQLQQAIQKLQSQ--I---------ENLKKQ-----------------XXXXXX----XX
XXXXXXXXXXXXXXXX--------------------------------------------
----------------------------------------------------XXXXXXXX
XXXXXXX--------------------XXXX----------------X--XXX-------
---------------------------XXXX-------------------X---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------XX----------------
------------------------------------------------------------
---------------------------------XXXXX-----X----------------
-----------------X------------------------------------------
----------------------------------------------------------XX
----------------------X-------------------------------------
----------------------------------------XXXXXXXXXXMSGECTTQVT
VS----------------------------------------------------------
---------------------IGGDSAVLS-GGAGESLVGTCGLGVRKGSFGS-NCSSVV
TGGSNIILGSG---------------------QGSVMGSCSVPSSGSS------SSCHTI
LMKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MQDVVEDYKS--KYEDEVNKRTAAE--NEF-VNLK
KDVDA----AYM-NKTELQAKVDSLV---GEINFLRPIYEAELS-QM-QTHISDTSVIL-
-SMD-------------------SNRNLDL--------DIIMAE----------------
---------------------YEEL-QV-TGGRYGD-DLRNTKQ--------------QI
AEINCMIQRLRSE--I---------DHVKKQ-----------------CANGQA----TI
ADAEQCGELVLKDARNKLEGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDMEITTYRKL
LEGKECR------------LNGEGV--GPVN---------ISMV----------------
-------QST----------------------------DFSGHGRES--GM---------
---G-----------------------------S--------------------------
------------------G--------------------------------------IGL
S------------------RCSSYSYSSG--HSL----GG-DF---------SSGSSR--
--GI-----------------------SI---------------------------GGSL
S----STGGSTST--I----KCIS--SSSRR-----------------------------
------------------------------------------------------------
---------------KNYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISYRSRGGG-----------------------GRKGGGGFQGFSSGS--
AIVSG-------SRRSTSGFSC--LSRHGGGG----------------------------
-----------------------------------GGYGAGGFGSQSVVGLG-GS----K
SISSSVAGGGGSFGSTSGFGGRG--GGF--------------GGFGGGS-----------
----------------------------------------GFGGGGFG----GGSFGGGR
--GPGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-IK-VD-PE-VQ-NRK-SQ-E------------------------------
------R-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-DM-LQQIDV---KS--RTINLEPMFQAFISQLHKQ----LDGLSVEK
-----------NSQES-----ELNHMQDLVEEYKK--KYEDETNKRTSAE--NDF-VTLK
KDVDN----GYM-NKVDLQANVDILT---QQIDFLRTIYEL-MS-QT-RETVTETNVTL-
-SMD-------------------NNRSLDL--------QGIIAEV-KAQYEDIAQRSKTE
AENLYHS---------K----YEEL-QI-TAGKHGD-SLKELKM--------------EI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKTVQE----SI
ADAEQRGENAIKDAQNKLTDL---------------EDALQQARENLARL-------LR-
------DYQELMNAK-------------------------------L-ALDIEIATYRKL
LEEEECR------------MSGEFSD-NV-T---------VSVT----------------
-------SST----------------------------ISSNTSSTSGFGGQG----SGG
RGS---SHGGG-----------------G----GGYSSG-SSSYGSGGRRSG------SK
S-GGGGSG-SGS--SIGGS----S--LGGGYGS---------------------------
-----------GS-------GSGGGR-------GGSGG----------------------
----------------G--------Y------------------GSS-----G-GSKGGY
S----S----G---------------GG----VSSGGGFSSSGGSRGGSS------SGGG
VSSSAKGSSGSGKG---------H---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTSKSTIRTH--S-----------------------------SSRGYSASS--
ARVPGS------HRSGFSSVS---VSRSRGSG-G--------------------------
------------------------L--------GGVCG-GAGFGSRSLYGLG-AS----K
RISI--GGGS-CAISG--GYGGRVG-----------------GGFGFGG------GAGS-
-----------G----FGFG-G-------------------GAGSGFGL-------GGGA
--GFGGGYGG--AGF------------PVC-PP-GG-I-QE-VT----------IN-Q-N
L--LTP-LN-LQ-ID-PT-IQ-RVR-TE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXX----XXXXXXXX
-----------XXXXX-----XXXXXXXXXXXXXX--XXXXXINKRTAAE--NEF-VTLK
KDVDA----AYM-NKVELQAKADSLT---DEINFLRTIYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQS---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQS----AI
ADAEQRGEMAIKDARNKLEGL---------------EDALQKAKQDMARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLF-AGG------------------------------ERLGFSGCS--
AVLS-GR-------FGSSRASF----KA-G------------------------------
----------------------------------VK--GAAPFGSRSLFSLG-GS----R
RQARC-A-G--SER-GG------------------------GFSLGHG------------
------------------------------------------------------CVGGGR
PGGFVGTIFGRAGLG-PA---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LSP-LN-VE-LD-HE-IQ-KVR-VQ-EREQIKALNNKFASFIDKVVELEHSLIHK--
---------------------MG-TIY-LS-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CGEKLEPIYEGHISGLRKQ----LETLSGDR
-----------VRLES-----ELRNMRDVVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKIELQAKVDSLT---EAIKFFKYLYEEEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRELDL--------DSIIDEVR-VQYEEITQKSKAE
AECLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SEVNRLIQRLHSE--I---------GNVKKQ-----------------CSNLET----SI
ADTEQRGDCALKDAQVKLHEL---------------EDALQQGKEELARL-------LL-
------EYQDLLNIK-------------------------------L-ELDIEIATYRKL
LESEESR------------MSGEYPNSVS-----------ISVISSINA---G-------
-------------------------------------------TGGAGFNVG--------
-----------------------------------FGAS--SSCS-YKSA--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------NC--VR-----ELK-------DPL---GKT-------P--GSSCVT
KKVSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSSKSTVRTH--SS----------------------------SRRAFGAGS--
ARLPGV------SRSGFSSVS---VSRSGG-S-G--------------------------
------------------------L--------GGVCG-GAGLGSRSLHGLG-SS----Q
RVSV--GGGS-CAVGG--RYGGRVG-----------------GGFGLGG------GTGS-
-----------G----CGFG-G-------------------GAGAGFGL-------GGGA
--GCAGGYGG--PGF------------PXX-XX-XX-X-XX-XX----------XX-X-X
X--XXX-XX-XX-XX-XX-XX-XXX-XX-X------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LDT-KW-TL-LQEQGT---KT--VRQSLEPLLEEYINNLRRQ----LDSVLGER
-----------GRLDA-----QLRGMQDTVEDFKN--KYEDEINKRTAAE--NEF-VTLK
KDVDA----TYM-NKVELQAKTDSLT---DEINFLRAFYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KSQYEAIAQRSRDE
AESWYQT---------K----YEEL-QV-TAGRHGD-NLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDAKGKLEGL---------------EDALQKAKQDMARL-------LK-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GPVN---------ISVT----------------
-------QST----------------------------VSSGYGGSS--GV---------
---S-----------------------------G--------------------------
------------------G--------------------------------------LGL
G------------------GGSSYSYGSG--FGL----GG-GF---------SSSSGR--
---------------------------GM---------------------------GSGL
N----SVGSSSSS--I----KYTTT-S-SSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGS------------------------------
-----------------------------------KGL-SGGFSSRSLYNVR-GT----R
SLSFNVASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGRSR
PTGFAGSMFGSVALG-SA---GP----SVFL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LH-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPIFEGYISSLRRQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVEALD---KETKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRSLDL--------DSIIAEVR-AQYEEIAQRSKTE
AETLYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLTQRLRSE--I---------ENVKKQ-----------------CSNLET----AV
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------MR-
------EHQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFNHY-PSG------------------------------DRIGFSGCS--
AIIS-SR-------LSSSSTSF----RG-G------------------------------
----------------------------------VKGVGAAAFGSKSLYSLC-GN----R
RISISATTG--ASR-TG------------------------SYALGHG------------
-----------------------------------------------------AGFGGGR
MSGFVGTIFGNAGLG-PV---CP----SVCP-P-GG-I-PQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---SN--CKRNLEPIYEGYISKLRRQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDFKK--RYEVEINKRTAAE--NEF-VVLK
KDVDA----AYM-NKIELQAKVDAVT---DEIKFLKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIINEIK-TQYEETAMRSKTE
AEALYQSK-------------IQEL-QV-TAGRHGD-DLKLTK--------------AEI
SELNRLIQRLRSE--I---------GSVKKQALSSS---SLPTPTSIECANLET----AI
ADAEQRGDCSLKDARAKLDEL---------------EGALHCAKEELARL-------LR-
------DYQELMSVK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTNT---G-------
-------------------------------------------PGGTGFSVG--------
-----------------------------------FGTS--STYS-YKPG--------T-
-----------------TD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------DYK-------EPM---TKG-------G----SPPA
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQNSCKSRGGVGGGGGRRG---------------GGGGGGGFRGFSSGS--
AIVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
------------------------G--------RGGGCGAGGFGSQSVVSLG-GS----K
SISIC-----GSFGSGGGFGGRG--GSF--------------GGFGGGS------SFGGG
SGFGG-----------------------------GG-----FVGGSVG----GGRFGGGG
--GPGG-FGGPG-----------------GILG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NIK-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LKT-KW-DL-LQQLDV---RS--RTTNLEPLFQTYISLLLKQ----VDTLSSER
-----------TAQDS-----ELNHMHDLVEDYKK--KFEDEINKRTAAE--NDF-VTLK
KDVDN----GYT-IKVALQANVEALA---QEIDFLRRLYEEELS-QL-QQTTTETSVVL-
-SMD-------------------NNRFLDL--------EGIIAEV-QSQYEDIAQRSKAE
AEALYHS---------K----YEEL-QL-VAGKHGD-SLREIKM--------------EI
SELNRMIQRLQGE--I---------SHVKKQ-----------------CKCVQD----AI
AEAEQRGEHAIKDAQQKLIDL---------------EEALQQAREDLARL-------LR-
------DYQELMSTK-------------------------------L-SLDIEIATYRKL
LEGEECS------------SQNFCSN-AISP---------TAVT----------------
-------SNT----------------------------ISSNVTSQTGFGGHS----VGG
RGS---IYGG-----------------------GEYSSG-SGSHGSGGRRSG------SR
S-GGGSSG-IGG--SRGGC----G--SGGGSRG---------------------------
-----------GS-------GSGGGYISGGGSRGGSGSGGGFN-----------------
-SGGGSGSGGGCSSSGG--------G------------------SRG-----GSGSGGGF
N----SGGGSG------------SG-GG----SGSGGCSGSGGGSRGGSSS-----GGGG
VSSSERGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

MLLAGKLNINIPLPGLARCPAQPMHIYIGTEPDGLSKEVIAPSLPGLCLLPAGPSLLAAS
LD-ALVTMSRQFSSRSAFSSRS----------------------------RRFYNISS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCQARGRCGG--------GGYGGHARGFGSRSLYNLG-GS----K
SISISLVGRSASG--FCQGGGV-------------------GGGLG------------GG
RSFGG-----------GG-----FGGG--------GFGGG-----GYG----GG-----A
--FG-GSSFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LH-LE-VD-PE-IQ-KVK-TR-E------------------------------
------R-EQI-MA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTNNLEPVLESYIGELQRQ----VDFLNAEQ
-----------MRQNS-----EIRSMQDIVEDYKS--KYEEEINRRTSTE--NDF-VVLK
KDVDA----AYM-GKVDLQSKADALF---GEVNFLKYLFEMELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RAQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-SAGRHGD-ELKSSKM--------------EI
AELNRTTQRLQAE--I---------SNIKKQ-----------------IDQMHE----AI
SDAEERGEQALQDAQQKLQGM---------------EAALQQAKEELARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------SSQ----------------------------TTVSGGGGGGG-Y-----S---
---------------------------------------------GGS-SLR--------
------------------------------------------------------------
------------------------GSGYSGGSR-GGGGG-------------------GY
SGG---SS-GS-YGGSSRGS----------------------------------SKYGGR
G----GGGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQITCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSRG------SRKSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GS----K
SISISVAGGGGGF--------GVGGGFGG-----------RGGGFGGGSGFGGGSG----
--FGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-LK-ID-PD-IQ-QRK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RSINLEPIFQAYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDIEFLKVLYDAEMS-QV-HQTITDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKM--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----SI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSTDLS--SSVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRGS-------G-
--------------------SRGG--GGGG------------------------------
---SVSGGGYS----SG--GGSGGRYGSGGGSGG--------------------------
------------------GY--G-SG---G-----GKHGSGG-GQH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEGF------------------------------------------GSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGG------------------------------DKGGFSGRS--
AVVL-RK-------AVGSAASY----RAAG------------------------------
-----------------------------------KGP-GAGFGSRSLYSLG-GN----R
CISFKMAGG--GVR-TG------------------------GYGFGPG------------
-----------------------------------------------------SGYGGGR
ATGFAGSMFGSVASG-PV---CP----SMCP-P-RG-I-YR-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDLVEDYKR--RYEVEINRRTAAE--NDF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDIEFLKCLYDAEVA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAKVR-AQYEEIALKSKAE
AEALYQTK----------ENQIQEL-QL-AAGRHGD-DLKHTK--------------NEM
SELNRLIQRIRCE--I---------VNVKK-----------------QCANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALLQAKEELARL-------LC-
------EYQELLSLK-------------------------------L-ALDMEIATYREL
LEGEECR------------MSGENPSSVS-----------ISVISSGG------------
------------------------------------------------------------
-------------------------------------------SSYYHP---------N-
-----------------SS-------ASADPGA---------------------------
----SSVA-------------------------------------------GSSGSAQ--
--------AGQTRAKGACAR-----DLK-------DSQDLKGKS------AS--ASTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GR-------NGSSSASF----RA-G------------------------------
----------------------------------IK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PR-VT----------V-NR-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPTYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKIELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIHSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIKSG------------------------------GTRNFSASS--
ASLLPG----C--RP---GFSSVSVSQSG-------------------------------
--------------------------------KSFGSGFGGGFGTRSLHSLG-GS----K
RISIGGGFRSSRA-----SFGV----ASCGLGVGGIGY------RV--------------
--------------------------GGAYG------------G---------YGFGGGM
APGAG-----------------G----IHE--V-T----VN-Q----------------S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------K-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQDHKT-------TRTNLEPMFEAYIANLRRQ----LDCLGGER
-----------GRLET-----ELKNMQDVVEDFKN--KYEEEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVDALM---DEINFLRAFYEAVKR-P--------------
------------------------------------------------------------
---WCPV-------------GRAGV-HT-GTRAAGS-LLT--------------------
-------SLLLIP--S---------EKLNRG-----------------CLEQAC----HV
EDPEQEVSL----FFNLLAEL---------------EEALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-SLDIEIATYRKL
LEGEESR------------LTGE------------------------G--VGAVNIS---
------------------------------------------------------------
----------------------------------VVSSSGGTSYSG-GGG--L-----CM
SGGSYGG----------GG------YSGSGLCYGGG------------------------
----------------------------GS---------GSFSSTSGR------------
------------------------------------------------------------
-----SV-S----------------------------------------GS---------
---------------------------------------------------------SSS
MRIVSKTS-SSKKS---YRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARSRG----RS-RGG---------FSSRSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-WS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYEEEAHRHATLE--NDF-VVLK
KDVDG----VFL-SKMVLEGKLETLR---EYLYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
TDAEQRGEVALKDAQAKVDEL---------------EAALRTAKQSLARL-------LC-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVMSRGVGGGL-GSTCGLGSGKGSPGS-CCTSIV
TGGSNIILGSG---------------------KDPVLDSCSVSGSSAGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTRF-PGE------------------------------ERLGFSGCS--
AVLS-GL-------NGSSSASF----RA-G------------------------------
----------------------------------VK--GLASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGSR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYLSNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--KYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CANLET----AI
ADAEQQGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGTS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKSSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSSRSA-----------------------------------
----------------CFAGSRG----RS-KG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------Q-F-G--
-------E-WS-A-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KI-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GALDA-----ELKACQDQEEEYKF--KYEEEAHRRTTLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QM-SAQLHGN-RMQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVDEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGSL-GSTCGLGGGKGSSGS-CCTSIV
TGGSNIILSSG---------------------KDPVLGSCSVSG----S------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--GIQ-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TT--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLT--L----------------------------------LAGG------
ERPG---------FS---GCSAVLSXXXX-------------------------------
-----------XXXXXXXXXXX------------XXX----XX--XXXXXXX-XX----X
XXXXXXXXX-------------------------------------XX--------XXX-
----XXALGR---GG-AGGG-----RPG-------------------------------G
---FVGTIFGSAGLG-PS---CP----SVCP-P-GG-I-PQ-VI----------VN-K-S
L--LAP-LN-VE-LD-RE-IQ-KVR-VQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-CSN-LE---------------------T-
SI-AD-TEQ-RG-DC-AL--KD---ARA-KLHELEGALQQGKEELARLLL-EYQELQNIK
-----------LELDV-----EIATYRKLLESEES--VI----SSTTAGTGGAGFSVGFC
TSSNY----SYKPSVVDVKTKV----------NYVTE-YKDALG-K-----TSGSNCAT-
-K-K-------------------ASR----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKTGAA------------------------------TKGGFSGCS--
AVLS-GG-------S---SSSF----RAGS------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GT----R
TISLNMAGG--SGR-AG------------------------GY-----------------
------------------------------------------------------GLGRSR
ASGFAGSMFGSVALG-PA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---NN--CRNSLEPVLDGHIANLQKQ----LEVLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTTAE--NEF-VILK
KDVDA----AYM-NKVELQAKVDALD---GDIKFFKCLHEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------YQEL-QL-AAGRHGD-DLKHTK--------------SEI
SDLTRLIQRLRSE--I---------ESVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELTSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSTA---G-------
---------------------------------------------MAGTGPG--------
-----------------------------------FGFSGTSTYG-YWP-----------
-----------------SS-------VGGGYSM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DSQ---GKP-------L--ALSSPA
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFSSRSGFRSG------------------------------GGFSSGS--
AGLVSF------QRRTTSSSV----RHSGG-GGG--------------------------
---------RFSG-------GRCGGG-------GGGGAGGGGFGSRSLVNLG-GS----K
SISISVAGGGGGRGGLGGGY---G--GG---------------GFGGG------------
-GFGGGSGG-------FG------------LGGG--FGGGGFGGGGFG----GGGFG-GG
--GFGG-----GSFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-TR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHSLEPYFENYISNLRRR----VDQLKSDQ
-----------SRMDS-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AFM-NKVDLQAKVDNLQ---QEIDFLTTLYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIISEV-KAQYEEIAQKSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-NLKSTKM--------------EI
SELNRVAQRLRSE--I---------DSVKKQ-----------------ISALQQ----SI
SDAEQRGENALKDAQSKLAEL---------------EDALQKAKEDMARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-------------------------GGF--------GSG-GG------GGGY-----GGG
SYGS---GG--------GS-----------YG----------------------------
-SGGGGGGSYGSGG-G-GGGGYGS-SSSSGGHRGGSGGGSR-------------------
----------SGGSSGGRGSS-----------------------------------SGGI
K----TSSGSSSV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------AVR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG-------GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGSG----IGG-------G-GF----GGFGS---GGGGFGG----------G
--------GFGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDG----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVRNSKI--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------ISNLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GSSYGSGGGSYG-S----G-
---GGGGGGRGSYGSGGSS-----------YG----------------------------
-S---GGGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGG-----------GGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CPAQR---GFSSRSA-----------------------------------
----------------CSARSRG----CS-RG---------GFSSRSLNSFG-GC----L
G-GS-RG-----------------------------------------------------
-----STWGSGG--R-VG-V---------------------------------Q-F-G--
-------E-WS-A-G-AG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GLSGSQQGLEPVFEACLDQLRKQ----LQQLQGER
-----------GGLDA-----ELKACRDQEEEYKF--KYEEEAHRRATLE--NDF-VVLK
KDADG----VFL-SKMELEGKLETLR---EYICFLKHLNEEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SRLHQEIQRLQSQ--I---------ENLRKQ-----------------NASLQA----AI
ADAEQRGELALKDAQAKVHEL---------------EAALRTAKQNLAQL-------LC-
------KYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECPSQITIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGVGGGL-GSTCGLGGRKGSSGS-CCTSIV
TGGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLAHY-PSR------------------------------ERLGFSGCS--
AVLS-GR-------LCSSSASF----RT-G------------------------------
----------------------------------VK--GSATFGSKSLFSLG-GG----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GCGR
LGGFVGTVFGSAGLG-PV---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PD-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRNNLEPILESYISGLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---EEIKFLKCLHEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-TQYEEIALKSKAE
AEALYQTK-------------IQEL-QV-TAGQHGD-DLKFTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTGA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SGYS-YKPA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLALY-PGA------------------------------ERLGFSGCS--
AIIS-GR-------FSRGPASF----RA-G------------------------------
----------------------------------AK--GALAFSSRSLFCAG-GG----R
RLALSAA----SGR-SG------------------------GLAQGIG------------
------------------------------------------------------GAGGGR
PGGFVGTVFGSAGLG-PT---YP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-VD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--GRNNLEPVYEGHISNMRKQ----LEILSGDR
-----------VRLDS-----ELRTMREVVEDCKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQTKVDSLT---DEIKFFKSLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NTRQLDL--------DSILTEVR-AQYEEVAVKSKAE
AEDLYQGK-------------IQEL-QI-AAGQHGD-DLKLTK--------------AEI
TELNRLIQRIHSE--I---------GNVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDQL---------------EGALQQAKEELARM-------LR-
------DHQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEESR------------MSGDYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------PGGPGFSVG--------
-----------------------------------FGAS--GSYS-YRPL--------A-
-----------------LE-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-SD-----PLK-------EPH---AKA-------S--GSSTAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-AG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SRGFSSRSLYSLG-GS----R
SFSFNVASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGWGR
ASGFPGSMFGSVTLR-PA---CP----SLCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDQ---NN--CRNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYRK--RYEEEINKRTAAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKYTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CTNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTSSVS-----------ISVINSSAP---G-------
---------------------------------------------TVGAGAG--------
-----------------------------------FGFGGTGAYG-YWP-----------
-----------------SS-------VSGGYSL---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKVRLGSAS-----EFK-------DTQ---AKT-------L--ALSSPT
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTLL-ACG------------------------------ERPGFSGCS--
AVLS-GR-------FGSSRSSF----RA-G------------------------------
----------------------------------VK--GAAPFGSRSLFSLG-GS----R
RQARC-A-G--SEW-GA------------------------GFALGRG------------
------------------------------------------------------GAGGGR
AGGFVGTIFGSAGLG-PS---CP----SRVP-A-WW-D-PS-GH----------RQQR-A
S----------------------------------------------WLPSTWELDREIQ
KVRVQER-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--SRKKLEPIYEGHISSLRKQ----LETLSGDR
-----------VRMES-----ELRSMRDIVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVDLQSKVDSLT---EEIKFFKHLYEEEIA-QM-QSHVSDTSVIL-
-SMD-------------------NNRELDL--------DSIIDEVR-VQYEEITHKSKAE
AECLYQIK-------------IQEL-QD-TAGQHGD-DLKFTK--------------AEI
SEINRLIQRLHSE--I---------GNVKKQ-----------------CSNLET----SI
ADTEQRGDCALKDARAKLHEL---------------EGALQQGKEELARL-------LL-
------EYQELQNIK-------------------------------L-ELDVEIATYRKL
LESEESR------------MSGEYPNSMS-----------VSVISSTTA---G-------
-------------------------------------------TGGAGFSVG--------
-----------------------------------FGTS--SNYS-YKPS--------V-
-----------------VD-------VKTKV-----------------------------
------------------------------------------------------------
--------------NY--VT-----EYK-------DAL---GKT-------S--GSNCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLTSY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--SVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NTRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKS------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQSSVSFRSG------------------------------GSRSFSTAS--
AVTPSV----S--RT---SFTSMSRSGGGGGSGFYRV-----------------------
----------------------------S-LGGAGGAGGAGGYGSRSLYNLG-GS----K
RISXXXXXXXXXX-----XXXX----XXXXXXXXXXXX------XX--------------
--------------------------XXXXX------------X---------XXXXXXX
XXXXXX-XXXXXXXX-XX----X----XXXX-X-XX-X-XX-XX----------XX-X-X
X--XXX-XX-XX-XX-XX-XX-XXX-XX-X------------------------------
------XXXXX-XX-XX-XX-XX-XXX-XX-XXX-XXXXXXXXXXXXXXXXXXXXXXXX-
XX-XX-XXX-XX-XX-XXXXXX-------XXXXXXXXXXXXX---XX------XXXXXXX
--------------------------------XXX--XYEDEINKRTTAE--NEF-VMLK
KDVDA----AYM-NKVELEAKADALM---DEINFMKLFFEAELA-QI-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEDIANRSRTE
AESWYQT-------------KYEEL-QQ-TAGRHGD-DLRNTKH--------------EI
SEMNRMIQRLRSE--I---------DNVKKQ-----------------CANLQS----AI
ADAEQRGELALKDARNKLAEL---------------EDALQKAKQDMARL-------LR-
------EYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LSGE------------------------G--VGPVNIS---
------------------------------------------------------------
----------------------------------VVTSNVSSSYGS-SGG--F-----GG
GFGGGLG----------GS------L-GGGLAGGSS------------------------
----GSY----YSSSS-GGTGLGGGLSIGS---------SGFSAGSGR------------
------------------------------------------------------------
-----GL-G---------------------------GGFGS------GGGS---------
---------------------------------------------------------SSS
VKFVSTTS-STRKS---FKS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPVSA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSF----RAGG------------------------------
-----------------------------------KGL-NGGFGSRSLYSLG-GA----R
SISFNVASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGRSR
PSGFAGSMFGSVAVG-ST---GP----SIFP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LH-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-AL-LQQLDL---NN--CRNNLEPIFEGYISSLQRQ----LETLSGDR
-----------VRLDS-----ELRTMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYL-SKVELQAKVDALD---RETKFFKCLYEGEIA-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIINEVR-AQYEDIAQRSKVE
AEALYQTK-------------FQEL-QL-AAGRQGD-DLKHTK--------------NEI
SELTRLTQRLRSE--I---------ESVKKQ-----------------CGNLET----AV
ADAEQRGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EHQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVVSSSTA---G-------
---------------------------------------------TVGTGPS--------
-----------------------------------YGFGSAGTYS-YRP-----------
-----------------GT-------L-GSYNM---------------------------
----LSGGCIT-----------------------------------G----SGNCSPR--
--------A-EVKAKLGGAG-----EFR-------DTP---VKT------SA------P-
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAA------------------------------GKGGFSGCS--
AVLS-GG-------SA---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GI----R
TISLNMANG--SGK----------------------------------------------
-----------S-------G--------------------------------AYGFGRGR
ASGFAGSMFGSVALG--T---CP----TVCT-P-XX-X-XX-XX----------X-XX-X
X--XXX-XX-XX-XX-XX-XX-XXX-XX-X------------------------------
------X-XXX-XX-XX-XX-XX-XXX-XX-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGFIANLRKQ----LETLSGDR
-----------VRLDS-----ELRNVREVVEDYKK--RYEDEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIN-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEDIALKSKAD
AEPPQTXX-------------XXXX-XX-XXXXXXX-XXXX----------------XXX
XXXXXXXXXXXXX--X---------XXXXX-----------------XASNLET----AI
ADAEQRGDTALKDARAKLDEL---------------EGALHQAKEELARM-------LK-
------ESQELLNVK-------------------------------L-ALDIEIATYRKL
LESEECR------------MSGEFPSPVS-----------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQVSCRSRRS-----------------------------------------
AVVSGG------SRRSASGFSC--VSRHGGGGGG--------------------------
-------------------------------------YGAGGFGSRSLVGLG-GS----R
SISISVAGGSGSFG------------FAGGS-----------------------------
-GGRGGGFLGSG----LGG----------------------------------G---LFG
------GFGGPGGSG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SR-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---ST--RTTRLDPLFQAYIGELKKR----VDGLSAQR
-----------TSQDS-----ELNSMQDLVEDFKK--KYEDEINKRTAAE--NDF-VTLK
KDVDS----TYM-SKVELEARVGVLR---EDLEFLQFLFATELS-QM-QQTITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-RTQYEEIAQRSKDE
AEALYHS---------K----KKKH-IL-LPLSRLC-QHARPIM--------------SC
SKGGPAIQRLQGD--I---------SHVKKQ-----------------CKSVQD----SI
ADAEQRGEHAIKDAKNKLTDL---------------EEALQQAREDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDFS--SNVT---------VSVT----------------
-------SSS----------------------------ISSNVASRAGLGGRGSG-----
---------SG----------------------GGFGSG-SSSYGSGGRGS-------G-
--------------------SRGG--GGASGYGGGSHG----------------------
--G----------------SGSAGGFGSGGGSRG--------------------------
------------------GSGSA-GGFGSG-GSSRGGSGSGGGSRGG-------------
-----------------SGGGSHGG-SGSA------GGFGSGGGSRGGSG------TGGG
VSGSEKGGLGAGESY------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIVNY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGR-SGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGFGGGG----IGG-------G-GF----GGFGS---GGGGFGG----GGFG-GG
--------GYGGGYG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRR----VDQLKSDQ
-----------SRLDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDS----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IANLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEES R------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGSYG-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGG---------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSARLRS----RS-RG---------GFSSRSLNSFG-GC----L
E-GS-RG-----------------------------------------------------
-----STWGSEG--R-LG-V---------------------------------R-S-G--
-------E-WS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GSSGSQQDLEPVFEACLDQLRKQ----LEPLQGER
-----------GALDA-----ELKACRDQEEEYKS--RYEEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYIYFLKHLNEEELG-QL-QTQASDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGD-RMQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NASLQA----AI
TDAEQHGELALKDAQAKVDEL---------------EAALRTAKQNLARL-------LC-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------ISAECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVMSGGVGGGL-GSTCGLGSGKGSPGS-CCISIV
TEGSNIILGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRHFSSRSGYRCGGG--------------------------G-GGFSSGS--
AGVVSY------QRRSTSSSV----RRSGG-GGG--------------------------
---------RFSG---------------G----VCGGGAGGGFGSRSLINLG-GS----K
SISISVAGGGGR-GGFGGGYGG-G--YG-------------GGGFGGG------------
-GFGGGGFGAG------------------------GFGVGGI-GGGFGG----GGFG-GG
--------GFGGGGF------------PVC-P--GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KIK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINT---ST--RTYSLEPLFEAYISRLRRT----VDQLKSDQ
-----------SRLDS-----ELKNMQDLVEDYRR--KYEDEINKRTNAE--NEF-VGIK
NDVDA----AYI-TKVDLQAKFDNLL---QEIDFYKTLYQAELS-QM-QTHISDTNVIL-
-SMD-------------------NNRNLDL--------NSIIDEV-KAQYEEIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGQHGD-SLKNTKV--------------EI
SELNRVIQRLRSE--I---------DSVKKQ-----------------ISSLQQ----AI
SDAEQRGENAIKDAQNKLNEL---------------EDALQKAKEDMARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRTL
LEGEESR------------MSGECV--PNVS---------VSVSTSHT------------
---------------------------------------SISGGGGRG--G---------
-------------------------VGF--------SSG-GGGY----------------
--GSGGGGGYG--SGGGSS-----------YG----------------------------
-SR--AGGSYGSGG-GSS-------G-------------S--------RRGGSGGGGG--
------SSGGSFISSGGRAS--------------------------------------ST
K----TSGGSSSV-------KFVST-SYSR------------------------------
------------------------------------------------------------
--------------------GPR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFNYYPA-G------------------------------EHLGFSGCS--
AIIS-GR-------VSSSSASF----RAGI------------------------------
-----------------------------------KG--SATFGSKSLFSLR-GN----R
GYALGQGAR---------------------------------------------------
-------------------------------------------------------GCGGR
VGGFVGTVFGSAGLG-PA---CP----SIYP-P-GG-I-PQ-VT----------V-NK-N
L--LAP-LN-VE-VD-PE-IQ-QVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYESYINNLRKQ----LEAQSGDR
-----------VRLDS-----ELRNMHDLVEDYKN--RYEVEINRRTAAE--NDF-VVLK
KDVDA----AYT-NKVELQAKVNSLT---DEIKFFKSLYEGXXX-XX-XXXXXXXXXXX-
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------XXXXXXXX-XXIQ---------
-----------------------EL-QV-TAGRHGD-DLKFTK--------------AEI
SDLSRLIQRIRSE--I---------GNVKK-----------------QCANLET----AI
TDAEQRGDCALKDARAKLDEL---------------ETALHQAKEELARM-------LR-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEESR------------MSGECPNSVS-----------I-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----R
HISFNVAGG--GVR-AG------------------------GYGCRPG------------
-----------------------------------------------------SGYGGGR
ASGFVGSMFGNVALG-PA---CL----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDM---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTK--------------SEM
VELNRLIQRIRCE--I---------GNVKKQ-----------------CASLET----AI
ADAEERGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSIS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------NS-------VGADLGA---------------------------
----SAVA-------------------------------------------GSSGSTQ--
--------SGQTKTTEVRGG-----DLK-------DSQ---GKS------TP--ASIPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PRG------------------------------ERLGFSGCS--
AVLS-GG-------IGSSSASF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSSGLG-PA---CP----SVCP-P-GV-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNMRKQ----LEMLSGDR
-----------VRLDL-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCVYEGEIT-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSA--
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------EIS-QI-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AEALYHS---------K----YEEL-QV-TVGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVTSKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRQS-------G-
--------------------SRGG--GGGGGS----------------------------
----ISGGGYG----SG--GGSGGRYGSGGGSKG--------------------------
------------------GS--I-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSMS----------------------------RRVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYARGRCGG--------GGYGIHGRGFGSKSLYNLG-GS----R
SISISLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RGFGV-----------GS-----IGAG--------GFGGG-----GFG----GGGFGGAG
--FG-TSNFGLGGFG------------PSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---SS--GTNNLEPLLENYIGGLRRQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELTAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EDALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISGGAGGGGSY-----GSGG
-------------------------------------------YGSG--SG-GGY-----
------------------------------------------------------------
---------------GGG------KSYRGGGAR-GGSGG-------------------GY
GSG---GG-G----GGGVS-----------------------------------YGGSSR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGG---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GIAGGFGG-----------RGGGFGGGSGF------GGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGI-G-------------------GFGGPG
------GFG------------------PGGYPG--G-I-HE-VS----------VN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RPINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QI-HQSVTDTNVIL-
-SMD-------------------NSRNLDL--------DSIIAEV-KAQYEEIAQRSKEE
AEALYHS---------K----YEEL-QV-TVGRHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDAKNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SSSYGSGGRRS-------G-
--------------------SRGG--GGGGGSISGGGD----------------------
---SISGGGYG----SG--GGSGGRYGSGGGSRG--------------------------
------------------GS--S-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYGSGGGGS------------S-
---SVK--GSSGEAF------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG-------GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGIGGG-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------NNLRRR----VDQLKNDQ
-----------SRLDS-----ELKNMQDLVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDG----AYM-TKVDLQAKLDNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------NSIIAEV-KAQYEDIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVRNSKI--------------EI
SELNRVIQRLISE--I---------DNVKKQ-----------------ISNLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVSTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------SSG-GSSYGSGGGSYG-S----G-
---GGGGGGRGSYGSG--------------------------------------------
------GGSYGSGG-GGGGHGSYGSGSSSGGYRGGSGGGG--------GGGSSGGRGS--
------GGGSSGGSIGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFS-T-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MPLSL----CRAQR---GFSTRSA-----------------------------------
----------------CSARSRG----CS-SV---------GFSSRSLNSFG-GC----L
G-AS-RR-----------------------------------------------------
-----STWGSGG--R-LG-V---------------------------------R-F-G--
-------E-QS-G-G-PG-L-S-----L-CP-P-GG-I-QK-V---------T-IS-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGCPQGLEPVFEACLAQLRKQ----LEQLQGER
-----------GALDA-----ELKACRDQEEEYKS--KYQEEAHRRATLE--NDF-VVLK
KDVDG----VFL-SKMELEGKLETLR---EYIGFLKRLYEEELA-QL-QTQDSDTSVVL-
-SMD-------------------NNRYLDF--------SSIITEV-RARYEEIARTSKAE
AEALYQT---------K----YQEL-QV-SAQLHGN-SIQETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKQQ-----------------NASLQG----AI
ADAEQRGELALKDAQAKVDEL---------------EAALRMAKKNLAQL-------LR-
------EYQELMSTK-------------------------------L-SLDVEIATYRRL
LESEECR------------MSGECPSQVTIS----------------S--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAVVSGGVDGGL-GGTCGLGGGKRSSGS-RCTSIV
TGGSSILLGSG---------------------KDPVLGSCSVSGSSSGS------SCHTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQLSCKSRGGG-GGG-----------------------GGRFRGFSSGS--
AVVSGG------SRGSTTSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGSF--------GSGGGFGS-----------RGSGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGGGALGGF-G-------------------NLGGLG
------GFG------------------PGGYPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LN-LK-ID-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-CFI-DK-VRF-LE---------------------Q-
QN-QV-LKT-KW-EL-LQQIDV---RT--CTINLEPLFQEYISRLQNQ----VNMLCAEK
-----------TSQDT-----ELNNQQDLVEEFRK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYI-NKADLQAKVDVLS---QELAFLKILFDAELS-QM-QQNVTETNVIL-
-SMD-------------------NSRNLDL--------NDIISEV-QSQYEEIAHRSKAE
AEALYHS---------K----YEEL-QI-TAGKHGD-SLKEVKM--------------EI
CELNRMIQRLQAE--I---------SQVRKQ-----------------CKNVQD----SI
ADAEQRGENALKDAQNKLKEL---------------EEALQKAKENLACL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDLS--SNVT---------VSVT----------------
-------SST----------------------------ISSNVASRAGFGGH--GSGGKW
SSS-------G----------------------GGYSSG-SSSYSSGGRGS-------S-
--------------------SRGG--GGG-SYGSGG------------------------
--------SFK--------GG------------S--------------------------
------------------GS--G-GGYSSG-----GGYSSGGGSRG------GA--G---
---------FG------GGGGSKSG-SGSG------G----------------------G
GSCSERGASGSGEGC------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASH----SAAG------------------------------
-----------------------------------RGA-GAAFGSRSLYSLR-GN----R
CISFSVAGG--GIR-AG------------------------GYGFRPG------------
-----------------------------------------------------SGYGAGR
ASGFAGSMFGSVGLG-PA---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CRKNLEPIFEGYISNLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINQRTAAE--NEF-VVLK
KDADA----AYA-VKVELQAKVDSLE---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NSRDLDL--------DSILAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKRQTFSVSN---EPAPCPLQCASLET----TI
ADAEQRGDCALKDAQAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISIISS--------------
------------------------------------------------------------
----------------------------------------N-SYTYHHP-----------
-----------------SS-------AGADLKA---------------------------
----SAVA-------------------------------------------GSSGGTR--
--------SGQTKTKGARGG-----DLK-------DSQ---GKS------TP--ASTPAR
-KTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNMASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSAAVG-SA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYVSNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKAELQAKVDALD---REIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQSK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TPGAGTS--------
-----------------------------------FGFSGAGTYG-YRS-----------
-----------------SS-------VSGGYSM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DLP---GKS-------S--ALSSPS
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-NRQVCKKSFS----G--------------------------RSQGFSGRS--
AVVSGS------SRMSCV-------AHSG--GA-G-------------------------
---------GGAC-------GF--------------RSGAGSFGSRSLYNLG-SN----K
SISISVAAGGSRAGGFGGGR-SSC-GFAG----------GYGGGFGGSYG-------G-G
F----GG-GR-------GVG-SGFGGAGGFG-------GAG--G--FGG---PGVFGGPG
--SFGGPGGF----G------------PGG-FP-GG-I-QE-VI----------VN-Q-S
L--LQP-LN-VE-ID-PQ-IG-QVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQQTT---GS--GPSSLEPCFESYISFLRKQ----LDSLLGER
-----------GNLEG-----ELKSMQDLVEDFKK--KYEDEINKRTAAE--NEF-VGLK
KDVDA----AFM-SKVELQAKVDSLT---DEVSFLRTLYEMELS-QM-QSHASDTSVVL-
-SMD-------------------NNRCLDL--------DSIIAEV-RAQYEEIAQRSKAE
AEALYQT---------K----LGEL-QT-TAGRHGD-DLRNTKS--------------EI
MELNRMIQRLRAE--I---------ENVKKQ-----------------NANLQT----AI
AEAEQRGEMALKDANAKLQDL---------------QAALQKAKDDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGECQ--SAVC---------ISVV----------------
-------SNV----------------------------TSTS--GSSG------------
--SSRAVFG-------------------------------------GVSGSG--------
----SGGY-KGG------------------------SS----------------SSSSSS
SGYGVSGGSGSGYGGVSSGSTGG------------RGS-------SGSYQSSSSGSRLGG
A--G----GISVSH----------SGMDSS----SGSI--------------QTSGGSGY
K----SGGGGSTS--IR----FSQT-TSSSQHSSTK------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHQFSSQSAFSSMS----------------------------RRVYSTSS--
---------------------------SAGS-GGG-------------------------
---------SRAVGSVCYARGRCGG--------GGYGIHGRGFGSRSLYNLG-GS----R
SISINLMGRSTSG--FCQGGGV-------------------G-GFG------------GG
RGFGV-----------GS-----TGAG--------GFGGG-----GFG----GGGFGGAG
--FG-TSNFGLGGIG------------PYC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--GTNNLEPLLENYIGDLRRQ----VDLLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLESRVDTLT---GEVNFLKYLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRTVQRLQAE--I---------SNVKKQ-----------------IEQMQS----LI
SDAEERGEQALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGVK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSVSGGEGGGGSY-----GSGG
-------------------------------------------YGSG--SG-GGY-----
------------------------------------------------------------
---------------GGG------RSYRGGGAR-GGSGG-------------------GY
GSG---GG------GGSGS-----------------------------------YGGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYNLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSGCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQITCKSRRGGGG--GGGG---------------------RFRGFSSGS--
AVISGG------SRRSTSGFSC--LSRHGGGR----------------------------
-----------------------------------GGSCGGGFGSQSLVGLG-GY----K
SISTSVAGYGGG--FGGR---GGS-GFGG------------GSSFGGSGGFGGGSGFGGS
RGFGGGG-FGGG----FGGG-SGFGGGSGFGG-GSG-----FGGGGFGG----GRFGGGG
--GFGG-FG-----G------------PGGFPG-GG-I-HE-VS----------VN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---GT--RTTNLDPIYQAYISTLKKE----VDRLLAER
-----------TSQDS-----ELNNMQDLVEDFKK--KYEDEINKRTSAE--NEF-VTIK
KDVDS----SYM-DKTELQAKVDLLM---QEAEFLRTLYDVELS-QL-QQTVTDTNVIL-
-SMD-------------------NNRSLDL--------DSIISEV-QSQYEIIAQKSKTE
SEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKSVQD----SI
ADAEQRGEHALKDARTKLTDL---------------EEAMQQARENLARL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MTGEIS--DNVS---------VSVT----------------
-------SST----------------------------ISSSVASKAGFGSGGS---SGG
RGS---Y-GG------------------------G------SSYGTGG------------
----RGSG-GGGYSSGGGS--RGG--SGS-------------------------------
---------------------GGGGYSSGGGSRGGSSSGGGGYSSGGGSRGGSGSGGGGY
SSGGVSRGGSGSGXXX-----------------------SGGVSRGG-----SGSGGGGY
S----SGGGS-------------------------RGGSGSGGGSRGGSG------SGGA
VSGSERGGAGSGES---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISSLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--KYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECX------------XXXXXXXXXX-----------XXVISSSTA---G-------
---------------------------------------------TAGAGTG--------
-----------------------------------FGFGNASTYG-YRS-----------
-----------------SS-------VGGGHGL---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFR-------NPQ---GRT-------S--ALTPPA
KKTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRTQR---GFSARSA-----------------------------------
----------------CSAHSGG-----------RG---GAGFSSRSLTSLG-GC----R
GGGS-RG-----------------------------------------------------
-----RTWGSRR--R-PG-A---------------------------------W-F-G--
-------E-GS-G-G-SG-R-S-----L-CP-P-GG-I-QE-V---------T-VN-Q-S
L-L-TP-LK-IE-ID-PQ-FQ-AVR-TQ-E------------------------------
------TQ-DI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-AL-LQQ--Q---GVSARPRGLETFFEAHLAQLRQQ----LEQLQRER
-----------RPLDA-----ELKACRDQEEEFKA--RYEQEARKRATAE--NDF-VVLK
KEADE----VFQ-SKMELEGQVEVLR---EYICFLRRLYEEILI-KL-PFFKKGTRS-L-
-KMT-------------------MNNRLKN--------EGIMGKKGKIRAEEGGLGMWRE
GRLPV-P---------T---QYQEL-QA-SAQLHGN-SMNETKV-------------Q-L
SQLHQEIQRLQSQ--I---------GSLKKQ-----------------NANLQS----DI
ADAEKRGELTLKDAQTKLEEL---------------EAALRTAKQNLAQM-------LR-
------DFQELLSTK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGEYTGQVTVS----------------V--GGGSTIT---
---SGGT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------GGGLMSTCGLRGTRDGAGS-GCSSIV
TGGSGVSRGSG---------------------QSSALGACSVTGSGSGSGS--GSSCGTI
LKRTVESSLKTSITYPSSHVNTTFSSSGKSPLVLISNAHSQQLGWPLQCCSCYLLPLQKQ
LVTWWRVRSWEVGGAWRASGTRDKATEQSPIDCSYHRWPVGGDSRPAAGGVASGSPCHPL
LSQEVTVNQSLLTPLNVEIDPEIQRVRTQEREQIKTLNDKFASFIDKVRFLEQQNKVLET
KWALLQEQGQTSGVARGSLEPLFETYLCNLRRQLDSLQNERGRLDAELRNMQDLVEDFRS
QYEDEINKRAGAENEFVVLKKDVDAAYTVQMGLCGQMGALSEEIDFLRHLYDMELSQVQT
RVSDTSVVLSMDNSRSLDLDGVIAEVREQYEEVARRSRAEAEALCQSRYEELQMTVVQHG
DSLRDTKNEIAELTRTVQRLQGEVDAAKKQCQELQPAIAEAERQGQLALKDAQQKLGDLE
AALHQAREELARLLRDFQALMSVKLALDVEIATYRKLLEGEESRMCGECPSAVSVSVTGS
STMALGGGAAGFGGGPPLVGGVGGVKSRFGSGVAYGPARGGPAGGTSVLRKTTTASRRS

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MQDLVEDFKN--KYEDEINRRTAAE--NDF-VVLK
KDVDG----SYM-NKVELQAKADALM---DEINFLKMIYNAELN-QM-QQQVSDTSVVL-
-SMD-------------------NNRSLDL--------DSIIREVK-AQYEDIANRSRTE
AESWYQSK-------------YEEL-QL-TAGRHGD-DLRNTK--------------VEI
SEINRMIQRLRNE--I---------DNVKKQ-----------------CANLQT----AI
SEAEERGEMALKDARAKLADL---------------EDALQKAKADLARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEESR------------LAGEGVGPVS-----------ICK-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGAA-------------------------------NRGFSGCS--
AVLS-GG-------S---SSSY----RAGS------------------------------
-----------------------------------KGL-SGGFSSRSLYSLR-GT----R
SISFNVAGG--SGR-TG------------------------AY-----------------
------------------------------------------------------GFGRNR
VSGFAGSIFGSGALG-PS---SP----SLCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPVYEGHISSLQKQ----LDTLSGDR
-----------VRLDS-----ELRNMRDTVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEMA-QM-QSHISDTSVIL-
-SMD-------------------NNRSLDL--------DSIISEVR-TQYEDIARKSKAE
AESAYQTK-------------FQEL-QL-VAGRHGD-DLKHTR--------------NEI
SELTRFMQRLRSE--I---------ENVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARGKLDEL---------------EGALQQAKEELARM-------LR-
------EHQELMSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSMP---G-------
---------------------------------------------TVGAGNS--------
-----------------------------------FGFNNTGIYG-YQS-----------
-----------------SS-------VGGGYGI---------------------------
----LPGGCVT-----------------------------------G----SGNCSSR--
--------G-ETKTRLGSAS-----EFK-------DIP---GKT-------L--ALGSPT
KKTVR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLTHF-PCG------------------------------ERLGFSGGS--
AVLS-GG-------IGSSSASF----RA-G------------------------------
----------------------------------VK--GSASFGSKSLFCLG-GS----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NR-S
L--LAP-LN-VE-LD-PK-IQ-RVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLEL---NN--CRKNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEITFFKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AQYEEIALKSKAE
AETLYQTK-------------IQEL-QV-TAGQHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GNVKKQ-----------------CTNLET----AI
ADAEQRGDCSLKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LESEECR------------MSGEYPNSVS-----------ISVISSTNA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--SSYS-YKTA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------ELK-------DPL---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSWQRN-INSRG------------------------------NKGNFSVHS--
AVMP-KK-------AMGSVAFY----HATA------------------------------
-----------------------------------QGA-GAGFSSQSLYNLG-GN----R
RIFSNVADS--GVW-AG------------------------GHSFEHG------------
-----------------------------------------------------SGYGSSQ
SRGFPGSMFGSVALG-PG---CL----SVCP-P-RG-I-HQ-VT----------I-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRKNLEPTYEGHISGLRKQ----LEMLSGDR
-----------VRLDS-----ELRSMRDVAEDYKK--RYEVEINQCTAAE--NEF-VVLK
KDADV----AYT-AKVELQAKVDSLD---KDIKFLKCLYDAEIT-QL-QTHASDTSVIL-
-SMD-------------------NNRDLDL--------ESIITEVH-THYEDIAWKSKTE
AEALYQTK-------------FQEL-QL-VAGQHGD-DLKHTR--------------NEM
SELNRFIQRIRCD--I---------ISVRK-----------------QCSNLET----AI
TDAEQRGDSALKDAQAKLDEL---------------EGALHQAKDELARM-------MH-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGGNPSSVS-----------IAISSSS-------------
------------------------------------------------------------
------------------------------------------GSG-YHP-----------
-----------------SS-------VSTDLGV---------------------------
----SSAA-------------------------------------------INLGSPR--
--------SGQTKTQGAQTG-----DLR-------DSQ---DKS------AS--GSAPAR
KTTR--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GR-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SISLNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGQGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDAQAKLDDL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFP--SP--------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSAN-----NYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLAHY-PGG------------------------------ERLGFSGCS--
AVLS-GR-------LSCSSASF----RT-G------------------------------
----------------------------------VK--GSAAFGSKSVFCLG-GG----R
RLALSAA----AGR----------------------------------------------
--------------------------------------------------------GGGR
LGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRNNLEPIYEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYDVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------IQEL-QI-TAGRHGD-DLKLTK--------------AEI
SELNRLIQRIRSE--I---------GSVKKQ-----------------CANLET----AI
ADAEQQGDCALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISSTSA---G-------
-------------------------------------------AGGAGFSMG--------
-----------------------------------FGAS--GGYG-YKPA--------A-
-----------------AD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-S------EFK-------DPL---AKT-------S--GSSCAT
KKAPR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------SS---SSF----RAGS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GV----R
S--LNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-TQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------WAGS------------------------II---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSNCIS-----------------------------------------GVCSVR--
--------GGEGRSR-SSAN-----DYK-------DTL---GKG-------S--SLSAPS
KKTSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSGRSGG-----------RS---RGTFSSRSLSSSR-GC----P
G-GS-RG-----------------------------------------------------
-----RTWGSGG--R-LG-V---------------------------------R-S-G--
-------E-GS-G-R-SG-F-S-----L-CP-P-GG-I-QE-V---------T-IN-P-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---GVSGSPQDLQPAFEAYVAQLRKQ----LEQLQRDR
-----------GALDA-----ERKACQDQEEEYKA--KYEEEAHKHATAE--NDF-VVLK
KDVDG----VFL-SKMELEGKLAALR---EHICFLKRLYGEELG-QL-QTQVSDTSVVL-
-SMD-------------------NNRCLDF--------SDIIAQV-RARYEQITQTSKAE
VEALYQT---------K----YQEL-QV-SAQLHGD-SMKETKV-------------Q-I
SQLHQEIQRLQSQ--I---------ENLKKQ-----------------NADLQA----AI
ASAEQRGEAALKDAQAKLDEL---------------EAALRAAKQELARL-------LR-
------DYQELMSTK-------------------------------L-ALDVEIATYRRL
LEGEECR------------MSGECTSQVTVS----------------V--VGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STVVSGGAGGSL-GGCSGLGGGKGSFGS-YCSSIV
TGGSSAILGSK---------------------EGPVWGSCSVSGSGSGS------SCRTI
LKKTVESSLKTSITY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-----------------------------------------------------VSVPQ--
SRKSIG----G-------------------------------------------------
-------------------------------------GLRGGFGTRSLQGFG-GS----K
RISINGGYHSSRR-----NFGG----ASCGLGIGGIGY------RA--------------
--------------------------GEAFG------------G---------YGFG---
---GG--MV-P-GA--EG---------IH-E-V--T---VN--Q-----------S-L--
L---TP--L--H-L--T--L--NN--K--F------------------------------
------A-S-F-I--D--KV--C--FL--E--Q--QN-K-VL-E-TK-WS-L--------
----------------LQDQKT-------ARANLEPIFEVYINNLRRQ----LDCLGGEY
---------------------------------------EEEINRHTAAE--NEF-VVLK
KDMDA----GYM-NKVELEAKVDALM---DEINFLRAFYKAELA-QL-QAQISKTSVVL-
-SMD-------------------NNHRLDL--------DSVIAEV-KAQYEEIANGSWAE
AESWYQT-------------KYEEL-QW-SAGQHGD-DLRTTRM--------------EI
SELMRAMQRLSSE--I---------DNLKKQ-----------------CTTLQA----TI
ADAEEHGELALKDARNKLAGL---------------EDALQKAKQDMARL-------LR-
------EYQELMNVK-------------------------------L-ALDIKIATYCKL
LEGVGSV---------------------------------------------------NI
------------------------------------------------------------
-----------------------------S----VVSSSGGTGYSG-GSG--F-----CV
GG---------------GG------Y-SGGLCY---------------------------
------------S-------------ATGD---------SSFSSTSGH------------
------------------------------------------------------------
-----SL-S----------------------------------------ST---------
---------------------------------------------------------SSS
MHIISKTS-STKKS---CRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSY----RAVS------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GT----R
SISLNVAGG--NGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LEP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINGRTAAE--NEF-VLLK
KDVDV----AYA-NKVELQAKVDSMD---QDIKFLKCLFDAEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLNL--------DSIIDEIR-SQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-NLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLEK----AI
ADAEQRGDNALKDARAKLDEL---------------EAALYQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TS----GG-FRP-----------
-----------------SS-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRSR-GSTS-----DYK-------DTL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRKTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGGGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGF---------GG-------G-GF----GGFGS---G-GGFGG----GGFG-VG
--------GYGGGFG------------PVI-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRT----VDQLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-AKVDLQAKLNNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-TVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IGNLQQ----SI
SDAEQRGENALKDAKNKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGSYGSGGGGG--S----R-
---GGYGSGGGSYGSGGSS-----------YG----------------------------
-S---GGGSYGSGG-GGGGHSSYGSGSSSGGHRGGS--------------GSSGGRVS--
------GGGSSGGSSGGRGSS-----------------------------------SGGV
K----SSGGSSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
ASLLPG------CRPGFSSVS---VSQSGKSF----------------------------
-----------------------------------GGGLGGGFGTRSLHSFG-GN----K
RISISGG------------YRSSRAS---------------FGG------------AACG
LGVSSI-----G----YRAG---------------------GAYGGYG------------
-------FGG--G--------------MAS-GA-GG-I-HE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-KVR-KE-E------------------------------
------K-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQEH-----KT--TRTNLEPMFEAYITNLRRQ----LECLGGER
-----------GRLET-----ELKSMQDVVEDFKN--KYEEEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVDALM---DEINFLRAFYEAELA-QL-QAQISETSVVL-
-SMD-------------------NNRSLDL--------NSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QR-SAGQHGD-DLRTTKM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CATLQA----SI
ADAEQRGELALKDAKHKLAEL---------------EEALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LTGEGV--GAVN---------ISVV----------------
-------SSS----------------------------GGTGYSGGGGLCMSGGS-----
-----------------------------------YSG--------G-------------
-----------GYSGS--G--------------------------------------LCY
G------------------GG------------G-----SGSF---------SSTSGR--
------------------------------------------------------------
-----SMSGSSSS--M----RIVSK-TSSSK-----------------------------
------------------------------------------------------------
---------------KSYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRAHSARS--
---------------------------SSGFGGGG-------------------------
---------SRTVGSVSQALGRGGG--------GGYGSHGRGFGSRSLYNLG-GS----K
SISFSMVGRNASG--FCQGRGS-------------------GGGFG------------GG
RSFGGGGFGSGG----GG-----FGGG--------GFGGGGFGGGRFG----GGGYGGSG
--FGGAGNFGLGGFG------------PSY-PP-GS-I-QE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-KI-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RSNNLEPVLESYISELRRQ----VDFLNSEQ
-----------MRKNT-----EIRGIQDVVEDYKN--KYEEEINKRTSTE--NDF-VVLK
KDVDA----AFM-GKVDLQSKADTLI---GEINFLKYLFDTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-QAQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
VELNRTIQRLQAE--I---------GNVKKQ-----------------VGQMHS----SI
SDAEERGERALQDAKQKLQDM---------------DEALQQSREELARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------SSQ----------------------------VSMGGGYSGGGG---------G
------------------------------------------------------YSG---
------------------------------------------------------------
---------------GGG------GS----------------------------------
------------------------------------------------------SKS-NS
K----YGGGSSRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSR
KRIVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSGYRSG------------------------------GGFSSGS--
AGIINY------QRRTTSSST----RRSGG-GGG--------------------------
---------RFSS---------CGGG--G----GGSFGAGGGFGSRSLVNLG-GS----K
SISISVARGGGRGSGFGGGYGGGG--FG-------------GGGFGGG------------
-GFGGGGF---------GG-------G-GF----GGFGSGGG-GGGFGG----GGFG-GG
--------GYGGGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SR-E------------------------------
------R-EQI-KS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHNLEPYFESFINNLRRT----VDQLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEDEINKRTNAE--NEF-VTIK
KDVDA----AYM-AKVDLQAKLNNLQ---QEIDFLTALYQAELS-QM-QTQISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEEIAQKSKAE
AESLYQS---------K----YEEL-QI-TAGRHGD-SVKNSKM--------------EI
SELNRVIQRLRSE--I---------DNVKKQ-----------------IGNLQQ----SI
SDAEQRGENALKDAKSKLNDL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDLEIATYRTL
LEGEESR------------MSGECA--PNVS---------VSVNTSHT------------
---------------------------------------TISGGGGRG--G---------
-----------------------GGGGY--------GSG-GGGYGSGGGGGSGG----R-
---GGYGSGGGGYGSGGSS-----------YG----------------------------
-SGG-GGGSYGSGG-GGGGHSSYGSGSSSGGHRGGSGG---------------GGRGS--
------GGGSSGGSSGGRGSS-----------------------------------SGGV
K----SSG-SSSV-------KFVST-TYSG------------------------------
------------------------------------------------------------
--------------------VTR-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MTQRSSVTIK--SG----------------------------GTRNFSASS--
ASLLPG------CRPGFSSVS---VSQSGKSF----------------------------
-----------------------------------GGGIGGGFGTRSLHSFG-GN----K
RISIGGG------------YRSSRAS---------------FGG------------AACG
LGVSGI-----G----YRVG---------------------GSYGGYG------------
-------FGG--G--------------MAP-GA-GG-I-HE-VT----------VN-Q-S
L--LTP-LH-LE-ID-PS-LQ-RVR-KE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-SL-LQEH-----KT--TRTNLEPMFEAYITNLKRQ----LECLGGER
-----------GRLEM-----ELKNMQDVVEDFKN--KYEEEIHRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELEAKVDALM---DEINFLRAFYEAELA-QL-QAQISETSVVL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIANRSRAE
AESWYQT---------K----YEEL-QR-SAGQRGD-DLRTTKM--------------EI
SELNRAMQRLRSE--I---------DNLKKQ-----------------CAALQA----SI
ADAEQRGELALKDAKNKLAEL---------------EDALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LTGEGV--GAVN---------ISVV----------------
-------SSS----------------------------GGTGYSGGGGLCVSGGG-----
-----------------------------------YGG--------A-------------
-----------GYSGS--G--------------------------------------LCY
G------------------G-------------G----SSGGF---------SSTSGR--
------------------------------------------------------------
-----SVSGSSSS--M----RIVSK-TSSTK-----------------------------
------------------------------------------------------------
----------------SYRS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGSA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GA----R
SISLNMAGG--KNS-TY-------------------------------------------
------------------------------------------------------GYSRNR
PSGFAGSMFGSVALA-PI---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRNNLEPIFEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFRCLYEGEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEIR-SQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRVIQRLRSD--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------ESALHQAKEELARM-------MR-
------DYQELMSVK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPSA----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-FRP-----------
-----------------NT-------VSAGYVA---------------------------
----NSGSCIS-----------------------------------------GVCSVR--
--------GGEARSR-ASGS-----DYK-------DTL---GKG-------S--SLSTSS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGG------------------------------DKGDFSGYS--
AVMP-RK-------AVGSVASY----RAAG------------------------------
-----------------------------------KGA-GAGFGSQSLYSLG-GN----R
CISFSVAGG--DVR-TG------------------------GYGFGHG------------
-----------------------------------------------------SGHRGGR
ASGFAGSIFGSVALG-PV---CP----SMCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-ME-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-QA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPVFEGYIGNLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRVVVEDYKK--RYEMEINKHTAAE--NEF-VALK
KDVDA----AYT-AKVELQAKVDSLD---KDIKFLKCLYDAEIS-QI-QTHASETSIIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-TQYEETALKSKAE
AEALYQSK-------------IQEL-QL-AAGRHGD-NLKYTK--------------NEM
SELNRLIQRIRCE--I---------GNLKK-----------------QCSNLET----AI
ADAEQRGDNALKDAQAKLDEL---------------EAALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSSG-----------
------------------------------------------------------------
-----------------------------------------SNYG-FHP-----------
-----------------SS-------VSADLGA---------------------------
----SSVA-------------------------------------------SGSGSAR--
--------GGDTKAKGALVG-----DPK-------DSE---GKS------TT--VVTPAR
-KSTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLHHR-PAG------------------------------ERTGFSGCS--
AVIS-GR-------VSTSSASF----RA-G------------------------------
----------------------------------VK--GTAAFGSRSLFSLG-GG----R
RLALCAA----AGR-GG------------------------AFALGHC------------
-----------------------------------------------------SGSGGGR
LGGFVGTVFGSAGLG-PV---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-NL-LQQLDL---NN--CRKNLEPIYEGYISNLRKQ----LETQTGDR
-----------VRLDS-----ELRNMQDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFFKCLYEGEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------ESALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSPVS-----------ICKYLCAGP-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSSRS--
---------------------------SAGS-GGG-------------------------
---------SRVVGSVCQGLGRCGGGG------SGYWSHGGGFGSRSLYNLG-GS----K
SISLSVAGRNASG--FRQGWGG-------------------G-GSG------------GG
LRFLSGRF-----------------------------TGLGFGGSSYG----GGGFGGA-
------GNLGFGGFG------------PVC-PP-GG-I-QE-VT----------IN-S-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TK-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXX----XXXXXXXX
-----------XXXXX-----XXXXXXXXXXXXXX--XYEDEINKRTNSE--NDF-VVLK
KDVDA----AYM-GKVDLQSKVDALL---GETSFLKYLFETELS-QM-QTDISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RMQYELIAQKSKDE
AEALYQT---------K-------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSAFAGA-----------RG---RAGFSSRSLSSSR-RW----R
G-SS-CE-----------------------------------------------------
-----RAWGAGA--R-QG-V---------------------------------R-F-G--
-------Q-GS-G-G-PG-L-S-----Q-CP-P-GG-I-QA-V---------T-VD-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TR-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-AL-LQQ--L---QGSHSPQGLECMFEACLARLRQQ----LEELQRER
-----------GALDS-----ELKTYQDQEDEYKS--KYDQEAHRHASVQ--NDF-AVLK
KDVDE----VFQ-SKMDLEGRLESLR---EYVCFLTRLYEEELG-QL-QTQADDMSVVL-
-SMD-------------------NNRCLDF--------NDIIAEV-RARYEEITQTSKAE
AEAVFQT---------K----YQEL-QA-SAQLQGD-SMKEARV-------------Q-I
SQLRQAIQRLQSQ--I---------ASLRTQ-----------------NGSLQS----AI
ADAEQHGEMALKDAQAKLDEL---------------EDALRAAKQDMAQM-------LR-
------EYQELLGTK-------------------------------L-SLDVEIATYRRL
LESEECR------------MSKENISQVTIC----------------E--YEGTLRV---
---GLPVVLRTL--------------LVVVP-------------------G---------
RICG----------GQVVMP--------GRICGGQMVV-------PGRVNGGQ-----MV
VPGRVDG----------GQVVIPGRVDGGQVVI---------------------------
----------------------------------PGRVDGGQVVVPGRVDGGQMVVPGRV
NGG-------Q-GVIPGRVD--G-GQVVVPGRVDGGQVVIPGRVNGGQGVIPGRVDGGQM
VIPGRVDGGQVVVPGRVDGGQM-----------VVPGRVDGGQV----------------
-----------------VVPGRVDGGQMVIPGRVDGGQVVVPGRVDGGQV----------
----------------------------------------------------------VV
PGRVDGGQMV-----------VPGRVDGGQMVVPGRVDGGQMVVPGRVDGGQVVMPEGDC
RGQMVIPGRVDGGQVVMPEGDCRGQMVIP-----------GRVDGGQMVMPGGDCRGQMV
MPGGDCRG----------------------QMVMPGGDCRGQMVMPGGDCRGQMVMPGGD
C-------------QMVMPGGDCRGQMVMP-GVG-DGQVGTCGLRGWKGGFGSGGCSSIV
TGGFDIPQGSE---------------------CSPSMGSCSVSGSGFSSGS--GSCCRTI
LKQTVESSRKTSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLNLY-PGG------------------------------ERLAFSGCS--
AIIS-SR-------VSSSTASF----RASG------------------------------
----------------------------------VK--GTATFGSRSLFNCG-GG----R
RLALSSR----AGR-GG------------------------SVLGPCM------------
------------------------------------------------------ATGGGR
RGGFVGTVFGSAGLG-PA---CP----SVCP-P-GG-I-PQ-VT----------V-NK-S
L--LSP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LGT-KW-EL-LQQLDL---NN--CKNNLEPILEGYTSNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDVVEDYKK--RYEVEINRRTAAE--NEF-VMLK
KDVDA----AYM-NKVELQAKVDSLT---DEIKFLKCLYEGEIA-QI-QSHISDTSVIL-
-SMD-------------------NNRDLDL--------DSIIAQVR-AQYEEIALKSKAE
AEALYQTK-------------IQEL-QA-TAGQHGD-DLKLTK--------------AEI
SDLNRMIQRIRSE--I---------GNVKKQ-----------------CSNLEM----AI
ADAEQRGDCALKDARAKLDEL---------------EAALLQAKEELARM-------MR-
------EYQELMSTK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGEYPNSVS-----------ISVISNTSA---G-------
-------------------------------------------AGGTGFSMG--------
-----------------------------------FGAS--SSYS-YKSS--------A-
-----------------VD-------VKTKG-----------------------------
------------------------------------------------------------
--------------SCG-GS-----ELK-------DAP---AKT-------S--GSSCAT
KKASR-------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSCQISYRSRGGG-----------------------GGKGGGGFRGFSSGS--
AIVSGG------NRRSTSSFSC--LSRHGGGG----------------------------
-----------------------------------GGCGAGGFGSQSVIGLG-GS----K
SISSSVAGGGGSFGSGGGFGGRGG-GGF--------------GSFGGGS------SIRGG
SGFGG-----------------------------GGFGGGGFGGGSFG----GGRFGGGG
--GPGG-FGGPGGFG------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NRK-SQ-E------------------------------
------R-EQI-KS-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQIDV---RT--RTTNLEPFFHAYINQLQKQ----VDALSSER
-----------TSQDS-----ELNNMQDLVEDYKK--KYEDEINKRTSAE--NDF-VTLK
KDVDN----GYM-NKVDLQATVDTLT---QEIEFLRRLYEAELS-QV-HETVTETNVVL-
-SMD-------------------NNRNLDL--------QGIIADV-QTQYEDIAMKSKAE
AETLYHS---------K----YEEL-QI-TAGKHGD-SLRELKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKNVQD----AI
ADAEERGERAIKDAQSKLTDL---------------EEALQQAREDLAKL-------LR-
------DYQELMNTK-------------------------------L-ALDIEIVTYQKL
LEGEECR------------MSGELSD-NV-T---------VSVT----------------
-------SST----------------------------VSSNVSSKSGFGGQG----SGG
RGS---SHGGG-----------------GGSGGGGYSSG-SGSYGSGGKRSG------SR
S-GGGGSG-LGS--SRGGS----S--SGGGYGS---------------------------
-----------GS-------GSGGGR-------GGSGS----------------------
----------------G--------G------------------GRG-----GSGSGGGY
G----SGGGSR---------------GG----SSSGGGVS----------------AGGG
VSSSIKGGSGSGEG---------H---------------------------------SSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
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---------------MELEGKLEALK---EFFCFLTQLYEEERN-QL-QTQGSDRSVVL-
-SMD-------------------NSRCLDF--------SDIIAEV-RARYEEIAWTSKAE
AEALFQN---------K----YKEL-QS-SAQLHGH-SMKETKI-------------Q-I
SQLQHVIQELQSQ--I---------SSLKGQ-----------------NANLQS----AI
SDAEQRGELTLKDAKSKLDEV---------------EDALRTAKQDMARL-------LR-
------DYQELMSTK-------------------------------L-SLDVEIAMYRRL
LEGEECR------------ISGECTSQVTIS----------------T--MGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------STIVPGGAGGNQ-GGTCEFRGGKGSFGS-SCSSVV
TGGFGNTLGSG---------------------QGPTLGSCSVSGSGFSSGS--SSSHHTI
LKETVESSLKTSIKY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IRSSG------------------------------DKGNFSVLS--
AVVP-RK-------TVGSVASY----WVSG------------------------------
-----------------------------------HEA-GTGFGSRSLYSLR-GN----R
PISFNVAGS--GAR-AT------------------------RHSLGHG------------
-----------------------------------------------------SGYGAGR
ASGFAGSMFGSVTLG-PT---CP----SVCL-P-WG-I-HH-VS----------V-NK-S
L--LAP-LS-VE-LD-PE-IQ-KIR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NS--CRKNLEPIYEGHISSLRKQ----LELLSGEK
-----------LRLDS-----ELRSMRDVVEDYKK--RYEVEITRRTAAE--NEF-VLLK
KDADA----AYM-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QL-QTHATETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-SHYEDIALKSKAE
TEALYQTK-------------IQEL-QL-AAGHHGD-NLKHTE--------------NEM
SELNRLIQRIRCD--I---------TNVKK-----------------QCSNLET----TI
ADAEQQGDSALKDARAKLDEL---------------EGALHQAKDELARM-------MR-
------EYQELMGLK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISSSS------------
------------------------------------------------------------
----------------------------------------YGTYG-YHP-----------
-----------------SS-------VNSDLAA---------------------------
----GVAA-------------------------------------------GSSSTSR--
--------SSQPKTRGSRAG-----DLR-------DSQ---DKS------AA--IGTPAR
-KITR-------------------------------------------------------
------------------------------------------------------------
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-------MSRQFTCKAGAA------------------------------AKGGFSGCS--
AVLS-GG-------ST---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GV----R
SISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PI---CP----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QEIKFFKCLYEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRDLNL--------DSIIDEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALHQSKEELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEFPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TPP--------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRHFSSQSAFSSRS----------------------------RQGYTNRS--
---------------------------SSGF-GGR-------------------------
---------SWAVG--------PGS--------GGYGGYGRGFGSRSLFNLG-GS----K
SISFGLVGRNASG--FHHSRGV-------------------GGGFG------------MV
RRFEGHGLGSSS------------------------FAGGRFGGGRFG----GGGFGAS-
---G-AVNFGPAGFG------------PSY-SP-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NR-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTNNLDAFFENFIGGLQMK----VDLLNTEK
-----------MRKTS-----EIRSMEDAVEDYKS--KYEDEINKRTNTE--NDF-VVLK
KDVDA----AFM-NKMNLESKAGTLL---EEVNFLKYLFEMELS-QV-QTHISDTNVIL-
-SMD-------------------NNRTLDL--------DSIITAV-QAEYELIIQRSKDE
AEALYQT---------K----FQEL-QI-SAGRHGD-DLKNTKM--------------EI
SELNRNIQRMQAE--I---------ASVKKQ-----------------VGRMHS----AI
SDAEERGERALQDAKQKLQDM---------------DEALQNSKENLARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LECEESR------------MSGEQQSHV--S---------ISVH----------------
-------SSQ----------------------------VSTSGGSGGGGGS-----G--G
-------------------------------------------YGGGGYSSGGASFGGS-
------------------------------------------------------------
-------------------------------------GG-------------------G-
YS---SGGGGS-YGVSHR-S--------------SSK-----------------------
-----SSGGSSRV-------QIIQT-STN-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------M-SRQSVCRSFGG---G--------------------------SRRGYSSCS--
AVGGGFGGSGGRSRISYSSFS---TSR---------------------------------
------------------------G--------TGGGGRCGGFSSRSLHNMG-GS----G
RISMGGSYG-GGYGCRIVGLGGGY-G--------------G-------------------
--------------------------GFGSI-------GGGVI---GGG---VGSFGGP-
------------VRG------------GPG-FP-GG-I-QP-VQ----------VD-S-S
L--LRP-VH-VD-ID-PQ-IQ-QVK-CQ-E------------------------------
------K-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LST-KW-EL-LQQQGP---SG--PRKNLDVIFENYIQGLRRR----LESLLGQR
-----------GELES-----ELQNMRQYVEEYKT--KYEEEINRRTAAE--NEF-VVLK
KDVDC----AYM-TKVELEAKVGALT---DEISFLRCIYEE-----M-QTISRDLSVVV-
-SMD-------------------NNRHLDL--------DSIIEEV-RRQYEQIAQNSRAE
AEAWYQS---------R----YEEL-QT-TAGRHGD-SLRNTKI--------------EI
QELTRNVQRLRAE--I---------ENVKKQ-----------------NQQLQA----AI
AEAEERGEMALKDARRKLEEL---------------ECALSKDKEELARL-------LK-
------EYQELLNIK-------------------------------I-ALDVEIAMYRKL
LEGEENR------------LCGDNP--SNVN---------VSVV----------------
-------GRT----------------------------TIAGGRAGG-------------
------------------------------------------------------------
-------F-GA-------------------------------------------------
---------GSGVGGGVCT----------------------------VGGGSIIGGSCGV
GGGV--------Y----------NGGFSSG----SGRM--------------CSSGGGTF
I----PTG-ASSV--RR----CVTT-TTVKSSGVKY------------------------
------------------------------------------------------------
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------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----QAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYCLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-SV---GP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLCGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADTEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------------------------MQELVEEYRS--KYEEEVNRRTTAE--NEF-VVLK
KDVDC----VFL-TKEELESKVDVLA---QELEVLRCVFAEELT-QL-DSQILDTSVIL-
-KMD-------------------NTRDLHM--------DLILQNV-ENWYQNIAHNSKQE
AEAFYHN-------------KIAEI-QN-NRSKFNE-ELKCNQH--------------EI
AELNRVTQRLRTD--L---------GNAKKQ-----------------VSNLQS----AI
CDAEQRGDIALKDARNKHAEL---------------QNAYQQSKDKLASL-------LR-
------DYQDLLNTK-------------------------------M-ALDIEIATYKMM
LEGEESR------------ICTGNP---------------VSVTMVSG--GYPVGECAAG
MGGAVAYGGAV------GR---SLEH---GVGT-------YS-GVGEGFSS---------
GSAG----------CIHTMG--------SRASAGSVGRA---------------------
--------------------------SGVGYGIRHSSG----------------------
---GGSGGVGGFGSNVTTKHVVGAGGGRHS---------SG---ISID------------
-------------GSCVSGH--H-GG-------VHHVVGGAGG-----------SGGH--
-----SIGG-------SGIGVHTSNVYAVGTGGGHSGSMHG-----GSR-----------
----------------------------------------------------------SE
VRNVHV---GSSVRKTAF------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GT----R
SISLNVAGS--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRGR
ASGFAGSIFGSVALG-PT---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELNRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDDL---------------EGALHQAKDELARL-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPSPVS-----------ICDCNLGRL---G-------
---------------------------------------------R--------------
-------------------------------------TYGSSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-S--S-----DYK-------DTL---GKG-------T--SLSASS
KKSGR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSARSA-----------------------------------
----------------CSDFSGA-----------RG---RTSFSSRSLSSSR-RC----R
G-SS-CG-----------------------------------------------------
-----RAWGAET--R-QG-V---------------------------------R-F-G--
-------Q-GK-G-G-PG-L-S-----Q-CP-P-GG-I-QA-V---------T-ID-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLECVFEACLARLRQQ----LEELQRER
-----------RALDS-----ELKTYQDQEDEYKT--KYDQEAYKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGNLESLR---EHVCFLTRLYEEELG-QL-QTQANDMSVVL-
-SMD-------------------NSRCLDF--------SDIIAEV-RARYEEITRTSKAE
AEAVFQT---------K----YQEL-QE-SAQLQGN-SMKEVQV-------------Q-I
SQLRQVIQKLQSQ--I---------GSLRKQ-----------------NDSLQS----AI
ADAEQQGEMALRDAQAKLDEL---------------EGALRAAKQDMAQM-------LR-
------DYQELMGTK-------------------------------L-SLDVEIAMYRRL
LESEECR------------ISKEHTSQVTVS----------------I--EEGSIVP---
---GRSCGGQ-----------------VVIP-------------------G---------
RSCG----------GQVVIP--------GGVCSGQVVI-------PGRNCGGQ-----VV
IPGRTCG----------GQVVIPGRTCGGQVTMPG-------------------------
---RECGGQVTVPGREHGGQVIVPGREHGGQVTVPGREHGGQVTVPGREHGGQVTVPGRE
HGG-------Q-VMVPGREH--G-GQVTIPGRECGGQVTIPGREYGGQVTVPGREHGGQV
TVPGREYGGQVTVPGREHGGQV-----------TIPGRECGGQVTIPGREYGGQVTVPGR
EYGGQVTVSGREYGGQVTVPGREYGGQVTVPGRECGGQVTVPGREYGGQVTVPGREYGGQ
VTVPGREC-GGQVTVPGREY-----------------------GGQVTVPGREYGGQVTV
PGREYGGQVTVPGRECGGQVTVPGRECGGQVTVPGREYGGQVTVPGREYGGQVTMPGREC
GGQVIVPGRECGGQVTMPGRECGGQVTVP-----------GREYGGQVTMPGRECGGQVT
VSGREYGG----------------------QVMLPGRECGGQVTVPGRECGGQVTMPGRE
CGGQVTMPGREHGGQVTVPGRECGGQVMLP-GRECGGQVGTCDHRGWKGSFGSGGCSSIV
TGGFDVPQGSG---------------------YSPIMGSCSVSGSGFSSGS--GSSCRTI
LKKTMESSRKTSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSCQISCKSRRAGGG--GGGG---------------------GFRGFSSGS--
AVVSGG------GRRSTSGFSC--LSRHGGGR----------------------------
-----------------------------------GGSGGGGFGSQSLVGLG-GY----K
SISTSVAGGGGG--FGGGSSFGGS-SFGG------------GGGFGGGSGFGGGSGFGGG
RGFGGG----SG----FGGG--GFGGGSGFGG--GG-----FGGGGFGG----GRFGGGG
----GG-FG-----G------------PGGFPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LD-VK-VD-PE-IQ-NVK-SQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDV---GT--RTTNLDPIFQAYIGMLKKR----VDSLSAER
-----------NSQDS-----DLNNMQDLVEDFKK--KYEDEINKRTSAE--NEF-VTIK
KDVDS----SYM-DKTELQAKVDILM---QEADFLRTLYDMELS-QL-QQNVTDTNVIL-
-SMD-------------------NNRNLDL--------DSIIAEV-QNQYELIAQKSKTE
TEELYHS---------K----YEEL-QV-TAVKHGD-SLKEIKM--------------EI
SELNRTIQRLQGE--I---------SHVKKQ-----------------CKSVQE----SI
ADAEQRGEHAIKDARTKLTDL---------------EEAMQQARENLAKL-------LR-
------DYQELMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGDFN--DNVS---------VSVT----------------
-------SST----------------------------ISSSVASKAGFGSGGQS--SGG
RGS---Y-GG------------------------G-GGG-GSIHGSGGRSSG------SR
G--GSGSG-GGGYSSGGGS--RGG--SGGGYSSGG-------------------------
---------GSGG-------GAGGGYSSGGGSRGG--SGGGGYSSGGGSRGGSGGGYRGY
SSGGGG--GYSSGGGS-----------------------R-----G--------------
G----SGGGG-------------------------GGGYSSGGGSRGGSG------SGGA
VSGSERGGSGSGEG---------C---------------------------------GSG
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------RRVYSTSS--
---------------------------SAAS-GGG-------------------------
---------SRAVGSVCHAQGRCGG--------GGYGSHGRGFGSRSLYNLG-GS----K
SISINLVERSASG--FRQSWGG-------------------G-GFG------------GG
RGFRV-----------GS-----IGAC--------GFGGG-----SFG----GGGFGGAG
--FG-ASNFGLGGFG------------PSC-PP-GG-I-QE-VT----------VN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RIK-TR-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--WTNNLEPLLESYIGGLQRQ----VDFLNAER
-----------MRQNT-----EVRSMQDVVEDYKS--KYEDEINKRTGSE--NDF-VVLK
KDVDA----AYV-SKVDLQSRVDTLT---GEVNFLKHLFLTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQRSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRMVQRLQAE--I---------SSMKKQ-----------------IEQMHS----LI
SDAEERGERALQDARQKLQDL---------------EEALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRQL
LEGEESR------------MSGELQSHV--S---------ISVQ----------------
-------NSQ----------------------------VSISG-----GSY-----GAGG
-------------------------------------------YGGG--SG-GGYGGDSS
R-------------G---------------------------------------------
---------------GGG------RSYGGGGSR-GGSGG-------------------GX
X-----------------X-----------------------------------XXGSGR
S----GRGS-SRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RRILE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----GGAQR---GFSARSA-----------------------------------
----------------CSAGSRG-----------RG---RGSFSSRSLNSFG-GC----R
G-GS-RG-----------------------------------------------------
-----MAWGSGG--R-PG-V---------------------------------R-F-G--
-------V-GS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-IN-Q-D
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--L---GVSDSPRGLESFFEDYLGRLRKW----LEELQRQR
-----------GTLDA-----ELKSCQDQEEEYKA--KYEQEAHKRATVE--NDF-VVLK
KDVDE----VFL-SKMELEGKLESLR---KHTCFLRRLYEEELG-QL-QTQAGDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITQTSKAE
AETLYQT---------K----YQEL-QA-SAQLHGN-SMKEIKV-------------Q-I
SQLQQAIQRLQRQ--I---------EDLKKQ-----------------NANLEA----AI
AHAEQRGELALKDAQAKVTEL---------------EAALRTSKQNMARL-------LR-
------QYQELMSTK-------------------------------L-ALDVEIATYRRL
LESEECR------------MSGEWNSQVTIS----------------V--GGG-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SAILSGGTCG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTLFGG--------------------------------ERLGFSGCS--
AVLS-GR-------FGSSRSSF----RAGV------------------------------
-----------------------------------KG--AAPFGSRSLFSLG-GS----R
RQARSAGSE----R-GA------------------------GYALGH-------------
-----------------------------------------------------GGAGGGR
PGGFVGTIFGSAGLG-PT---CP----SVCP-P-GG-I-PQ-VI----------V-NK-S
L--LAP-LN-VE-LD-RE-IQ-KVR-VQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFYKCLFEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-VQYEEIALRSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRLIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKDELARM-------MR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------MSGEYPSP----------------VSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSSGYG-LRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGEGRNR-SSAS-----DYK-------DTL---GKG-------S--SLSTSS
KKGSR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSCGSRGGGGGGGGGSWGFSGSSVKGGSRGFSGSFSRGGSRGFSSGS--
AVVSSG------SRRSASSSSC--LMRHGGG-----------------------------
------------------------------------------GSSQSLIGLG-GN----K
SISMSVAGRGSGFCVRGGSFGGGS-SFGG------------G-GFG-GGSFGRGSGFGGG
SGFGG-----G-----------GFGR-------GSGFGGGGFGGGSS---FGGGRFGLGG
--GFGG-PGGSGGFG------------PGGYPG-GG-I-HE-VT----------VN-P-N
L--LEP-LN-VK-ID-PE-FQ-NVK-SE-E------------------------------
------R-EQI-KK-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LTT-KW-EM-LQQIDV---SS--RSPNLEPLFEMYISSLKQK----VDGLTAEK
-----------SKQDS-----ELNNMQDLVEDFKK--KYEDEINKRNSCE--NDF-VTIK
KDVDS----AYT-KKVELESLMNVLK---EELEFLTVLYEAEMS-QM-QQCITDTNVIL-
-SMD-------------------NNRSLDL--------EGIIKEV-QSQYEEIAQRSKTE
AETLYHS---------K----YEEL-QI-TAGKHGE-SLKEIKM--------------EI
SELNRMIQRLQGE--I---------AHVKKQ-----------------CRSIQD----SI
ADAEQRGEHALKDARHKMEEL---------------EEALQHTKEELVRL-------LR-
------DYQELMNVK-------------------------------I-ALDLEIATYKKL
LEGEENR------------ISGEVP--NNVS---------ISIS----------------
-------SST----------------------------ISSSVASKAGFRGSGGGGGSGG
RGS---S-----------------------------SGG-GGGYGSGGRGSS------SG
G---------GGYGSGGRSSSSGG--GGGGYGSGG-------------------------
---------RGSS-------SGGGGGGYSSGSRGS-------------------------
GSGGGSSGGR------------------------------GSSSGGG-----SGGGGGSY
G----SGG------------------------------QGSSSGSR-GSG------SRGG
GSGGSGGGQGEEES---------C---------------------------------GSS
---------VSFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKPGAV------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----W
SMPFNVASG--PGR-AV------------------------GY-----------------
------------------------------------------------------GFSRGR
ASGFAGSMFGNVTLG-PS---SP----SMYL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-IE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-DL-LQQLDL---NN--CRKNLESIYEGHISGLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDMVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALE---GEIKFFKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKTE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------SEI
SELTRLVQRLRSE--I---------ESVKKQ-----------------CSSLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEEFC------------NPP--LPITF-----------PAVISSSTA---G-------
---------------------------------------------TAGGVAG--------
-----------------------------------FGFGGTNTYG-YRP-----------
-----------------SS-------VSGAYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPC--
--------G-EAKTRLGSAS-----EFK-------DIQ---GKT-------S--ALSSPT
KKTMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSGG------------------------------DKGNFSVHS--
AVLP-RK-------AVGSLASY----RTAS------------------------------
-----------------------------------KGA-GAGFSSRSLYNLG-GN----R
QISINVAGG--SGR-AG------------------------GYGFWHG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-LA---CP----SVCP-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-TQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---SN--CKKNLEPILEGYISNLRKQ----LETLSADR
-----------VRLDS-----ELRSMRDQVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-AKVELQAKVDSLD---KDIKFLKCLHDAEIA-QI-QTHASETSIIL-
-SMD-------------------NNRDLDL--------DSIIDEVR-VHYEDIALKSKAE
AEALYQTK-------------MQEL-QL-AASRHGD-DLKHTK--------------NEM
SELNRLIQRLRCE--I---------GNVKKQPFPVCS---KPAPHPLQCANLET----AI
ADAEQRGDNALKDARAKLDEL---------------EAALQQAKEELARM-------LR-
------EYQELMGLK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISV-----------------
------------------------------------------------------------
--------------------------------------ISSSSYG-YHP-----------
-----------------SS-------SGADLGA---------------------------
----SGVV-------------------------------------------GSSSSTR--
--------SGQIKTKGARGG-----DLK-------DSQ---GKS------TP--ASAPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLL-GG-------S---SSSY----QAGA------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GP----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGNVALG-SM---CP----SVCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-NKVELQAKVDALD---GEIKFFKCLYEGEIT-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKTE
AEALYQTK-------------FQEL-QL-AAGRHED-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CTNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVLNSSMA---G-------
---------------------------------------------AAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFK-------DSQ---GKT-------L--ALSSPT
KKTMRQK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------MASTSTTIRSH--SS----------------------------SRRGFSASS--
ARLPGV------SRSGFSSVS---VSRSRGSG-G--------------------------
------------------------L--------GGACG-GAGFGSRSLYGLG-GS----K
RISI--GGGS-CAISG--GYGSRAG-----------------GSYGFGG-------AGS-
-----------G----FGFG-G-------------------GAGIGFGL-------GGGA
--GLAGGFGG--PAF------------PVC-PP-GG-I-QE-VT----------VN-Q-S
L--LTP-LN-LQ-ID-PA-IQ-RVR-AE-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LDT-KW-TL-LQEQGT---KT--VRQNLEPLFEQYINNLRRQ----LDNIVGER
-----------GRLDS-----ELRNMQDLVEDLKN--KYEDEINKRTAAE--NEF-VTLK
KDVDA----AYM-NKVELQAKADTLT---DEINFLRALYDAELS-QM-QTHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEV-KAQYEEIAQRSRAE
AESWYQT---------K----YEEL-QV-TAGRHGD-DLRNTKQ--------------EI
AEINRMIQRLRSE--I---------DHVKKQ-----------------CANLQA----AI
ADAEQRGEMALKDAKNKLEGL---------------EDALQKAKQDLARL-------LK-
------EYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------LNGEGV--GQVN---------ISVV----------------
-------QST----------------------------VSSGYGGAS--GV---------
---G-----------------------------S--------------------------
------------------G--------------------------------------LGL
G------------------GGSSYSYGSG--LGV----GG-GF---------SSSSGR--
---------------------------AI---------------------------GGGL
S----SVGGGSST--I----KYTTS-SSSSR-----------------------------
------------------------------------------------------------
---------------KSYKH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQLTYKQGAV------------------------------TKGGFSGCS--
AVLS-RG-------S---SSSY----RAGA------------------------------
-----------------------------------KGL-NGGFGSRSLYSLG-VT----R
SMPFNVASG--SGR-AG------------------------GY-----------------
------------------------------------------------------GLGWGR
ASGFAGSMLGNVALG-PS---SP----SMYL-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---NN--CRQNLEPIYEGHISSLRKQ----LDMLSGDR
-----------VRLDS-----ELRSMREMVEDYKK--RYEEEINKRTTAE--NDF-VVLK
KDVDA----AYM-MKVELQIKVDVLE---EEIKFFKCLYEREIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DSIITEVR-AQYEDIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTQ--------------NEI
SELTRLVQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LC-
------EYQELMSVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGAGAG--------
-----------------------------------FGFGGAGTYG-YWP-----------
-----------------SS-------VSGAYGM---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-EAKTRLGSAS-----EFK-------DVQ---GKT-------L--ALSLPA
KKTIR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
--------------------------------------------------KGGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGGFGSRSLYSLG-GT----R
SISLNVASG--NGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVALG-PV---CT----TVCP-P-GG-I-HQ-VT----------V-NE-S
L--LEP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRRQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINRRTAAE--NEF-VLLK
KXXXX----XXX-XXXXXXXXXXXXX---XXXXXXXXXXXXEIT-QI-QSHISDMSVIL-
-SMD-------------------NNRNLNL--------DSIIDEIR-SQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGQHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTCKSGAA------------------------------TKGGFSGCS--
AVLS-GG-------SS---SSF----RAGG------------------------------
-----------------------------------KGL-NGGFGSRSLYSLG-GA----R
NISFNVASG--SGK-SG------------------------GY-----------------
------------------------------------------------------GFGRGR
ASGFAGSMFGSVGLG-PV---CP----TVCP-P-GG-I-HQ-VT----------I-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--RYEEEINKRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVESMD---QEIKFFRCLFEAEIA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
SELTRLIQRIRSE--I---------ENVKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECS------------SLPEWVLASA--------------PSAAII---S-------
---------------------------------------------S--------------
-------------------------------------TSGGSGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSSSCIS-----------------------------------------GVCSVR--
--------GGEGRSW-GSTN-----DYK-------DNL---GKG-------S--SLSAPS
KKASR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQCSSRSVCRSG----------------------------G-RGFSSGS--
AGLVSF------QRRSTSSSV----RRSGG-GGG--------------------------
---------RFSG-------GFCGSG-------GG----GGGFGSRSLVNLG-GC----K
SISFRSRGCS-GFGGGS---------------------------FGGG------------
-SFGGGGYGGGS----FGG-------G-GYGGGS--FGGS-FGGGGYG----GGSFG-GV
--GY-G-----GGFG------------PVC-PP-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PE-IQ-KVK-SQ-E------------------------------
------R-EQI-KT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVDT---ST--RTHSLEPFFEAYISDLRGK----VDHLKSDQ
-----------SRMDS-----ELKNMQDMVEDYRN--KYEEEINKRTNAE--NEF-VTIK
KDVDS----AYM-NKVDLQVKVDNSR---HEIEFLTALYEAELS-QM-QTHISETNVIL-
-SMD-------------------NNRSLDL--------DSIIAEV-KAQYEDIAQRSKAE
AEALYQT---------K----YEEL-QI-TAGKHGD-SVKNSKM--------------EI
AELNRMIQRLRSE--I---------DSVKKQ-----------------ISQVQQ----SI
SDAEQRGENALKDAQNKLNEL---------------EDALQQAKEDLARL-------LR-
------DYQELMNTK-------------------------------L-ALDMEIATYRTL
LEGEES R------------VGLKMT--ESLF---------AAVSTSHT------------
---------------------------------------SISGGSVRG--G---------
-------------------------GGY--------SSG-GGSYSSGGGG-------GSG
GYSS---GG--------VS-----------YG----------------------------
-SGGGGG-SYS------------T-GGSSGGRRGGSGGGG--------GS---SGGRG--
------SSGGSFGSSGGRGSS-----------------------------------SGGQ
K----TSSGSSSI-------KFVST-TYSR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRTKR---GFSAHSA-----------------------------------
----------------CSALLGG-----------RS---KGSFSSRSLSSFD-GC----R
G-AS-RG-----------------------------------------------------
-----RAWGSRG--R-QG-V---------------------------------W-F-G--
-------Q-GS-G-G-PG-L-S-----L-CP-P-GG-I-QE-V---------T-VD-K-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--L---EVSDSPQGLEPVFEDYLAHLRRQ----LEQLQRER
-----------GALDA-----ELKACQDQEEEHKA--KYEEEARKHATVE--NDF-MVLK
KDVDG----VFL-SKMELEGQLEVLR---EYVCFLKRLYEEELG-QL-QIQASDTSVVL-
-SMD-------------------NNRCLDF--------NDIIAEV-RARYEEITQNSKAE
VETLYQT---------K----YQEL-QA-SAQLHGD-SMKETKV-------------Q-M
SQLQQAIKRLQSQ--I---------ASLKEQ-----------------NANLQS----AI
ADAEHRGKLALKDAQAKLDEL---------------EGALRKAKQDMARL-------LR-
------EYQELMSTK-------------------------------L-ALDVEIATYHRL
LEGEEYW------------WGSLKGPGNM-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-IKSSG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVAGG--GIQ-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKH----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYA-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASRHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AI
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STVA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSQSAFSSRS----------------------------KRVYSLGS--
---------------------------SAGS-GGG-------------------------
---------RLAVGSVCQARGRCGGG-------GGYGSHARGFGSQSLYNLG-GS----K
SISSNLVERSSSG--FRQGGGV-------------------GGGFG------------GA
S-FGGR----------GSGG-GGFGGG--------AFGGGGFGGGGYG-----G-----G
--FG-GSNFGLAGFG------------ASC-PL-GG-I-QP-VS----------IN-Q-S
L--LQP-LD-LE-VD-PE-IH-RVK-TQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLNT---ST--QPFSLEPALENYISELRRQ----VDFLNAEQ
-----------MRQNS-----EVMNMQDVVETYKN--KYEEEINRRTNNE--NDF-VILK
KDVDA----AYV-NKVDLQSKVDLLV---AESNFLKHIFEMELS-QM-QTYISETNVIV-
-SMD-------------------NNRSLDL--------DSIIEAV-QIQYEMIAQKSKEE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSRM--------------EI
ADLNRTIQRLQAE--I---------SSLKKQ-----------------NDQMRS----LI
SDAEEKGDQALQDAAQKLQGM---------------EEALQQSKEHMARL-------LR-
------DYQALLGAK-------------------------------L-SLDVEIATYRRL
LECEESR------------MSGELQSHV--S---------ISVQ----------------
-------SSQ----------------------------VSLSGGGGGGSSS-------WG
-------------------------------------------YSSRG-GAGGGYGGGSQ
------------------------------------------------------------
----------------------------------GGSGG-------------------GY
G----ASGGGN-YGGSSK-S--------------GRK---------------------FG
G----KSGGSSKL-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
KHIVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRARR---GFSARSA-----------------------------------
----------------CSAQSVG-----------RG---RAGFSSRSLSSFG-GC----R
G-SS-RG-----------------------------------------------------
-----RTWGSWG--R-LG-V---------------------------------R-L-G--
-------E-GS-G-G-PG-L-S-----L-CP-P-GG-I-QQ-V---------T-IN-Q-S
L-L-TP-PK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-QI-RV-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-RL-LQQ--Q---GLSDGPQGLESFFEAYLVRLRTQ----LEQLQRER
-----------GSLDA-----ELKSCQGQEEEYKA--KYECEAYRRATLE--NDF-VVLK
KDADG----VFL-SKMEMESKVKDLK---EYICFLKHLYEEELA-QL-QTQATDMSVVL-
-SMD-------------------NNRCLDF--------RDLIAEV-RARYEEITRTSKAE
AELLYQT---------K----YREL-QA-CAQLHGN-SMKETKV-------------Q-I
TQLQQTIKKLQSQ--I---------ETVKNQ-----------------NASLQV----AI
ADAEQRGELTLKDAQTKLAEL---------------EAALRTAKQDIARL-------LR-
------DYQELMSAK-------------------------------L-SLDVEIATYRRL
LEGEECR------------MSGECASQGTLG----------------E--GFPRRIE---
---DSA------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------V----------------
-----------------T------------------------------------------
----------------------------------------------------------L-
---------------------AP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------FLAAVGGGADGGL-AGSCGLGGVKGSFGS-SCSSVV
KGGSSVVKGGS-------SVVKGGSSIILGSGQGPVVGSSSVSGSSSSS------TSHTI
LKKTVESSLKKSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLNYFKSGG------------------------------DKGNFSVHS--
AVVP-RK-------TVGNLASY----RTVG------------------------------
-----------------------------------QGA-GAGFGSRSLYSLG-GN----R
HISFNVAGS--GVR-AG------------------------GYSFGHG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PS---CA----SVCL-P-GG-I-HQ-VT----------V-NK-N
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPIYEGHISSLRKQ----LETLSGDR
-----------VRLDS-----ELRNMRDVVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKVELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-AHYEDIALKSKAE
AEALYQTK-------------IQEL-QL-AAGRHGD-DLKHTR--------------NEM
SELNRLIQRIRCD--I---------TNVKKQVGSYYP-----DWEDLSLFSH--------
------------------------------------SPSLQMSQEGLEEL-------TC-
------HGPQLISIG-------------------------------V-RIQ---------
-------------------------VHVS-----------PSVIS---------------
------------------------------------------------------------
----------------------------------------SSHYGYYGHQ--------P-
-----------------SS-------VSADLGA---------------------------
---------------------------------------------------GGASSTR--
--------SSQTKTPGARAG-----DLK-------ESQ---GKS------AP--ASTPAR
-KTTR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKSGAA-------------------------------NRGFSGCS--
AVLS-GG-------S---ASSY----RAGG------------------------------
-----------------------------------KGL-GGGFSSRSLYSLR-SP----R
SISFNVASG--SGR-TG------------------------GY-----------------
------------------------------------------------------GFGRNR
ASGFAGSMFGGGALG-PS---NP----SLCL-P-GG-I-HQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQLDL---SN--CRRNLEPVYEAHISSLQKQ----LDSLSGDR
-----------VRLDS-----ELRGMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIT-QM-QSHISDTSVVL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEDIALKSKAE
AEMVYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGDCALKDAQAKLDDL---------------ERALHQAKEELARM-------LR-
------EHQELMSMK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEHTNAVS-----------ISVISSSTT---G-------
---------------------------------------------AVGAGTS--------
-----------------------------------FGFSNPSTYG-YRP-----------
-----------------SS-------VAGGYGI---------------------------
----LSGGCVT-----------------------------------G----SGNCSPR--
--------G-DTKTRLGSAS-----EFK-------EVS---GKT-------L--ALGSPS
KKTMRADRQSSIS-----------------------------------------------
----------------------------------------------------------VQ
------------LWFS--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CRAQR---GFSAHSA-----------------------------------
----------------CSSFSGA-----------RG---RTGFSSRSLSSSR-RC----R
G-SS-CG-----------------------------------------------------
-----RAWGAET--R-QG-M---------------------------------R-F-G--
-------Q-GK-G-G-PG-F-S-----Q-CP-P-GG-I-QA-V---------T-VD-Q-S
L-L-TP-LK-IE-VD-PQ-FQ-VVK-SQ-E------------------------------
------TR-EI-RS-LN-NQ-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQ--L---QGNRSPQGLECIFETCLARLRQQ----LEELQRER
-----------RALDS-----ELKTYQDQEDEYKS--KYDQEAYKHASVQ--NDF-VVLK
KDVDE----VFQ-SKMDLEGNLESLK---EHVCFLTRLYEEELG-QL-KTQADDMSVVL-
-SMD-------------------NNRCLDF--------SDIIAEV-RARYEEITRTSKAE
AEAVFQT---------K----YQEL-QE-SAQLQGN-SMKEAQV-------------Q-I
SQLRQAIHRLQSQ--I---------GSLRKQ-----------------NDSLQS----AI
ADAEQQGEMAVRDAQAKLDEL---------------EAALRTAKQDMAQM-------LR-
------DYQELMGTK-------------------------------L-SLDVEIATYRRL
LESEECR------------ISKEHTSQVTMS----------------I--TEGGIVP---
---GRTCGGQ-----------------VVVP-------------------G---------
RIGT----------GQVVMP--------GRECGGHVVV-------PGRGSGGQ-----VT
MPGRGSG----------GQVTMPGRE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------CGGQEVIPRGECGGQVTMPGREYGGQ
VTMPG------------REYGG-QV-----------------------------------
------------------------------------------------------------
-----------------------------------------------------------T
VPRGECEGQVTMPGREYGGQVTVPGREYGGQVTVP-------------------------
-----------------------------------RGELGTCGHRGWQGSFGSGGCSSIV
TGGFEIPQGSG---------------------YSPIMGSCSVSGSGFSSGS--GSSCRTI
LKKTVESSRKMSVIY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFSPVV---QG------RPSVPGS
--------------------------------VLG--CWAQSPNTHA----------CVH
TCTH-------N-THAGTRTHKHTNT---PNFSFPMWTSSQELA-QL-HAQISETSVVL-
-SMD-------------------NNRKLDL--------DSIISEV-KAQYEDIANRSRAE
AESWYQI-------------KYEEL-QR-SAGRHGE-DLRSTRM--------------EI
SELNRVIQRLRSE--I---------ENVKKQ-----------------CATLQA----AI
ADAEQRGELALKDAKHKLAEL---------------EEALQKAKQDMARQ-------LR-
------EYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------LSGE------------------------G--VGPVNIS---
------------------------------------------------------------
----------------------------------VVTNTVSSGYGG-GSG--F-----GG
GLGGGLG----------GG------L-GGGLGGGGS------------------------
----SSF----YSSSS-G------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MNRQFTCKPGAA------------------------------SNRGFSGCS--
AVLS-GG-------S---SSSY----RAGV------------------------------
-----------------------------------KGL-GGGFSSRSLYSLR-GA----R
NVSFNVAGG--SGH-AG------------------------GF-----------------
------------------------------------------------------GFGRSR
TSGFAGSMFGSVALG-TS---SP----AVCL-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CRKNLEPIYESHISSLRKQ----LEALSGDR
-----------VRLDS-----ELRTMRDAVEDCKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKVDALD---GEIKFLKCLYEGEIA-QM-QSHISDTSVIL-
-SMD-------------------NNRNLDL--------DGIISEVR-AQYEDIALKSKAE
AETLYQTK-------------FQEL-QL-AAGRHGD-DLKHTR--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CSNLET----AI
ADAEQRGECALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EHQELMSVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVISSSTA---G-------
---------------------------------------------TAGTGTG--------
-----------------------------------FGFSGTGTYG-YRP-----------
-----------------SS-------VGGGYGM---------------------------
----LPGGCVT-----------------------------------G----SGNCSPR--
--------G-ETKTKLGSAS-----EFK-------DAP---GKS-------L--ALSSPS
KKAMR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFSSRS----------------------------SRVYSVGS--
---------------------------PAGS-GDG-------------------------
---------SRAVGSVCQARGRCGGG-------GGYGSHAGRFGSRSLYNLG-GS----K
SISISLVGRSASS--FCQGRGA-------------------GGGFG------------GG
RSFGGGGFGGGG----YG----------------------------------GGSLGDSG
--FG-GSNFGVGGFV------------FSC-PP-GG-I-QE-VT----------IN-Q-S
L--LEP-LC-LE-VD-PE-IQ-RIK-TQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQINT---ST--WTNNLEPILESYISKLQKQ----VDFLNAEQ
-----------MRQSS-----EIRSMQDVVEDYKN--KYEEEINRRTSCE--NDF-VILK
KDVDA----SYM-SKVDLQSKADILF---EEVEFLKCLFQLELS-QM-QTNITDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RTQYELIAQKSKEE
AEALYQT---------K----YQEL-QI-TAGRHGD-ELKTSKM--------------EI
SELNITIQRLQAE--I---------SNVRKQ-----------------IDQMYT----AI
SDAEERGDRALKDAQQKLQDM---------------EDALQQAKEDMARL-------LR-
------DYQELLGTK-------------------------------L-SLDVEIATYRKL
LEGEECR------------WAILQQRG---------------------------------
--------------------------------------------------Y-----GGGS
-------------------------------------------SPG----GSGGYGGGSR
G-----------------------------------------------------------
----------------------------------GSGGG-------------------YF
GSRSGSGSGGS-YRGSS--------------------------------------KGSSK
S----GGGGSSRV-------QIIQT-STN-------------------------------
---------------------------------------------------------TSH
RARILPRLV----AHTPHKAGPSPVPFPTPSL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSHRFSSQSAFSSRS----------------------------KRAYSSRS--
---------------------------SSGF-GGG-------------------------
---------RQAVGSV--SRGRYGGGSY-----------GGGFSSRSLYSLG-GS----K
SIFGNLVGRSASG--FCQGGGA--------------------GGFG------------GG
RS---------------FGG-SGFGGG--------AFGGGGYGGGRFG-----GGFGGAG
--FG-ASNFGLGGFG------------PSY-PS-GG-I-HE-VT----------IN-Q-S
L--LEP-LH-LE-VD-PE-IQ-RVK-TQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RTSSLEPIFESYISQLQRQ----VDFLSSER
-----------SRQNM-----EIRSMQDVVEDYKS--KYEDEINKRTNAE--NDF-VVMK
KDVDA----AFM-GKSDLQSKVDTLY---EEVNFLKYLFDTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRSLDL--------DSIIDAV-RVQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGKHGD-DLKNSKM--------------EI
SELNRNIQRLQAE--I---------ASVKKQ-----------------IEQMHG----SI
SDAEERGERALQDAKQKLQDM---------------DEALQLSKEELTRL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LEGEESR------------MSGELQSQV--S---------ISVQ----------------
-------SSQ----------------------------VTVGGS------G-----GGSG
-------------------------------------------RYRSS------SRSSGG
------------------------------------------------------------
---------------GGGGSYRGGAGSR--GGGGGGGS----------------------
------GSYGS-YGSS-SKS--------------SSKY----------------GGGGGG
G----RSGGSSRT-------QIVQT-STH-------------------------------
---------------------------------------------------------SSR
RRVVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFTYKSGAA------------------------------AKGGFSGCS--
AVLS-GG-------S---SSSY----RAGG------------------------------
-----------------------------------KGL-SGGFSSRSLYSLG-GA----R
SISFNVAS--GSGW-AG------------------------GY-----------------
------------------------------------------------------GFGQGR
ASGFAGSMFGSVALG-SV---CP----SLCP-P-GG-I-HQ-VT----------I-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSVREVVEDYKK--RYEEEINKRTTAE--NEF-VVLK
KDVDA----AYM-SKVELQAKADALD---GEIKFFKCLYEGEIA-QI-QSHISDTSIIL-
-SMD-------------------NNRNLDL--------DSIIAEVR-AQYEEIARKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKHTK--------------NEI
SELTRLIQRLRSE--I---------ESVKKQ-----------------CANLET----AI
ADAEQRGDCALKDARAKLDEL---------------EGALQQAKEELARM-------LR-
------EYQELLSVK-------------------------------L-SLDIEIATYRKL
LEGEECR------------MSGEYTNSVS-----------ISVINSSMA---G-------
---------------------------------------------MAGTGAG--------
-----------------------------------FGFSNAGTYG-YWP-----------
-----------------SS-------VSGGYSM---------------------------
----LPGDCVT-----------------------------------G----SGNCSPR--
--------G-EARTRLGSAS-----EFR-------DSQ---GKT-------L--ALSSPT
KKT---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
G------------SS---RMSCV-------------------------------------
----------------R------SRGAS---GACGFRSGGGGFGSQSLYNLG-GY----K
SISMGVVAGGSRAGGFGGRRSICGSGFGGGYGGGFGGG------FGGG--------FGG-
----GRGVG----GG-FGGAG-GFGGPGGFG------------G---------PG----G
---FS-VPGGFGGPG--G---FG----PGGF-P-GG-I-QE-VT----------IN-Q-S
L--LQP-LN-VE-ID-PQ-IG-QVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-XXX-XX---------------------X-
XX-XX-XXX-XX-XX-XXXXXX---XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-----------XXXXX-----XXXXXXXXXXXYED--EI----NKRTAAE--NEF-VGLK
KDVDA----AYM-NKVELQARVDSLA---DEINFLRNFYDMXXX-XX-XXXXXXXXXXX-
-XXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXQRSKAE
AEALYQT-------------KLGEL-QT-TAGRHGD-DLRSTKS--------------EI
MELNRTIQRLRAE--I---------ENLKKQ-----------------NANLQT----AI
AEAEQHGEMALKDARDKLNEL---------------EAALQKAKDDLARM-------LR-
------DYQDLMNTK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGE------------------------C--QSAVSIXX--
------------------------------------------------------------
-----------------------------------XXXXX-----X-XXXXXX-----XX
XX-------------------------XXXXXXXXX------------------------
---------------XXXXXXXXX----------------XXXXXXXX------------
--------------XX---------XX------XXXXX---XX-----------XXXX--
-----XX-X---------------------------XXXXX------XXXX---------
---------------------------------------------------------XXX
XXXXXXXX-XXXX-XXXXXXXX-XXXXXXXXXXXXXXXXXXX-XXXX-----------XX
XXXXSSSQQSS-----------K-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-SCQISCKSRGRG-GG------------------------GGGFRGFSSGS--
AVVSGG------SRRSTSSFSC--LSRHGGGGR---------------------------
---------------------------------GF---GGGGFGSRSLVGLG-GT----K
SISISVAGGGGGF--------GAGGGFGG-----------RGGGFGGGSGFGGGSGFGGG
SGFGGGGFGGGG----FGG--GRFGGFGGPGGV-G-------------------GFGGPG
------GFG------------------PGGYPG-GG-I-HE-VS----------IN-Q-S
L--LQP-LN-VK-VD-PE-IQ-NVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQMNV---GT--RTINLEPIFQGYIDNLKRY----LDGLTAER
-----------TSQNS-----ELNNMQDLVEDYKK--KYEDEINKRTAAE--NDF-VTLK
KDVDN----AYM-IKVELQSKVDLLN---QDLEFLKVLYDAEIS-QM-HQSVTDTNVIL-
-SMD-------------------NSRHLDL--------DSIIAEV-KAQYEEIAQRSKDE
AEALYHS---------K----YEEL-QV-TAGKHGD-SLKEIKI--------------EI
SELNRVIQRLQGE--I---------AHVKKQ-----------------CKNVQD----AI
ADAEQRGEHALKDARNKLNDL---------------EEALQQAKEDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEES------------------------------------VT----------------
-------SST----------------------------ISSNVASKAGFG----GSGGRG
SSSG--G---------------------------GYSSG-SGSYGSGGRGS-------G-
--------------------SRSG--G-GGG-----------------------------
---SVSGGGYG----SG--GGSGGRYGSGGG-----------------------------
-------------------S--G-SG---G-----G-YGSGG-GKH------SS--G---
-------------------GGSRGG-SSSG------GGYSSGGGGS------------S-
---SVK--SSSGEAL------------------------------------------GSS
---------VTFSFR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQFSSRSAFSSRS----------------------------RRVCSASS--
---------------------------SAGS-GGG-------------------------
---------SRIVGSVCQARGRCGG--------GGYGSHGRAFGSRSLYNLG-GS----K
SISISLVGRSSSG--FQQGRGA-------------------GGGFG------------GG
RGFGG-----------GS-----FGG-------------G-----AYG----GGSFGGSG
--FG-ASNFGLGGFG------------PSC-PM-GG-I-QE-VT----------IN-E-S
L--LEP-LH-LE-VD-PE-IQ-RIK-AQ-E------------------------------
------R-EQI-MV-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LQT-KW-EL-LQQVNT---ST--RSNNLEPILENYISELQRQ----VDFLNAEQ
-----------MRQNT-----EVRSMQDVVEDYKN--KYEDEINKRTSSE--NDF-VVLK
KDVDA----AYM-SKVDLQSRMDTLA---GEIDFLKYLYMTELS-QM-QTHISDTNVIL-
-SMD-------------------NNRFLDL--------DSIIDAV-RSQYELIAQKSKDE
AEALYQT---------K----YQEL-QI-TAGRHGD-DLKNSKM--------------EI
AELNRQIQRLQAE--I---------GNVKKQ-----------------NDQMRS----AI
SDAEERGERALQDARQKLQDM---------------EDALQQSKEELARL-------LR-
------DYQAMLGAK-------------------------------L-SLDVEIATYRKL
LEGEECR------------MSGELQNHV--S---------ISVQ----------------
-------NSQ----------------------------VTVSGAAG-G-GR-----GSGG
-------------------------------------------YGGSG-G--GGYSG-GY
G-------------G---------------------------------------------
---------------GS--------GSRGGGAR-GGSGG-------------------GY
GGG---SG-GS-YGGSRSK-----------------------------------YGGGGG
R----SGGS-SRV-------QIVQT-STN-------------------------------
---------------------------------------------------------TSH
RLIRE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------M-NRQVCKKSFS----G--------------------------RSQGFSGRS--
AVVSGS------SRMSCV-------AHSG--GA-G-------------------------
---------GGAC-------GF--------------RSGAGSFGSRSLYNLG-SN----K
SISISVAAGGSRAGGFGGGR-SSC-GFAG----------GYGGGFGGSYG-------G-G
F----GG-GR-------GVG-SGFGGAGGFG-------GAG--G--FGG---PGVFGGPG
--SFGGPGGF----G------------PGG-FP-GG-I-QE-VI----------VN-Q-S
L--LQP-LN-VE-ID-PQ-IG-QVK-AQ-E------------------------------
------R-EQI-KT-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-KV-LET-KW-EL-LQQQTT---GS--GPSSLEPCFESYISFLRKQ----LDSLLGER
-----------GNLEG-----ELKSMQDLVEAFKK--KYEDEINKRTAAE--NEF-VGLK
KDVDA----AFM-SKVELQAKVDSLT---DEVSFLRTLYEMELS-QM-QSHASDTSVVL-
-SMD-------------------NNRCLDL--------DSIIAEV-RAQYEEIAQRSKAE
AEALYQT---------K----LGEL-QT-TAGRHGD-DLRNTKS--------------EI
MELNRMIQRLRAE--I---------ENVKKQ-----------------NANLQT----AI
AEAEQRGEMALKDANAKLQDL---------------QAALQKAKDDLARL-------LR-
------DYQELMNVK-------------------------------L-ALDVEIATYRKL
LEGEECR------------MSGECQ--SAVC---------ISVV----------------
-------SNV----------------------------TSAS--GSSG------------
--SSRGVFG-------------------------------------GVSGSG--------
----SGGY-KGG------------------------SS----------------S---SS
SGYGVSGGSGSGYGGVSSGSTGG------------RGS-------SGSYQSSSSGSRLGG
A--G----GISVSH----------SGMDSS----SGSI--------------QTSGGSGY
K----SGGGGSTS--IR----FSQT-TSSSQHSSTK------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------M-NKVELQAKLDSLA---DELNFLRNLYETELC-QM-QKTVSDTSVVL-
-SMD-------------------NNRCLDL--------DSIIAEV-KAQYEEIANRSRLE
AEAWYQS---------K----YKEL-QA-TAGKHGD-SLRDTKA--------------EI
SELNRVIQRLRAE--I---------ENVKKQ-----------------CESVQS----SI
ADAEQRGELALKDARDKLTEL---------------ETALKKAKADLAQQ-------LR-
------DYQELMNVK-------------------------------L-ALDIEIATYRKL
LEGEECR------------WVGIGL--DHIL---------LSQW----------------
-------EGC----------------------------SAEYLLLRYQ------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQLN-VKSGG------------------------------DKGNFSVHS--
AVVP-RK-------AVGSLASY----CAAG------------------------------
-----------------------------------RGA-GAGFGSRSLYSLG-GN----Q
RISFNVTGG--SVR-SG------------------------GYSFRPG------------
-----------------------------------------------------SGYGGGR
ASGFAGSMFGSVALG-PA---CS----SVCP-P-GG-I-YQ-VT----------V-NK-S
L--LAP-LN-VE-LD-PE-IQ-KVR-SQ-E------------------------------
------R-EQI-KA-LN-DK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKKNLEPILEGYISNLRKQ----LETLSGDR
-----------VRLDS-----ELRSMRDLVEDYKK--RYEVEINRRTAAE--NEF-VVLK
KDADA----AYT-VKMELQAKVDSLD---KDIKFLKCLYDAEIA-QI-QTHASETSVIL-
-SMD-------------------NNRDLDL--------DSIIAEVR-MHYEEIALKSKAE
AEALYQTK-------------IQEL-QL-AASQHGD-DLKHTR--------------SEM
AELNRLIQRIRCE--I---------GNVKKQTFSVSR---EPAPCPLWCASLET----AV
ADAEQRGDNALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LEGEECR------------MSGENPSSVS-----------ISVISS--------------
------------------------------------------------------------
-----------------------------------------SSYSYHHP-----------
-----------------SS-------AGADLGA---------------------------
----STMA-------------------------------------------GSSGTTQ--
--------SGQTKTKEVRGG-----DLK-------DSQ---SKN------TP--GSTPAR
-KATR-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-MSLSP----CQAQG---GFSARSA-----------------------------------
----------------CSARSGS-----------RS---RGSFSSRSFSSFG-GC----R
G-GS-RG-----------------------------------------------------
-----RTWGSRG--R-LG-V---------------------------------R-F-G--
-------E-GS-G-G-PG-L-S-----L-CP-P-GG-I-QK-V---------T-ID-Q-N
L-L-TP-LK-IE-ID-PQ-FQ-VVR-TQ-E------------------------------
------TQ-EI-RT-LN-NQ-FA-SFI-DK-VQF-LE---------------------Q-
QN-KV-LET-KW-HL-LQQ--Q---EVGGRPRDLKPVLEAYLAQLRGQ----LEQLQNER
-----------GTLDA-----ELKSCRDQEEEYKT--KYEKEAHRRATVE--NDF-VVLK
KDVDE----VFL-SKMELDGKLEALR---EYITFLKRVYEEGLS-QL-PQDPA-MPVXX-
-XXX-------------------XXXXXXX--------XXXXXXX-XXXXXXXXXXXXXX
XXXXXXX---------X---XYQEL-QT-SAQLHGD-SMKETKV-------------Q-I
SQLHQMIQKLESQ--I---------ENLKKQ-----------------ITHLQS----AI
ADAEQRGELALKDAQAKLDEL---------------EGALRKAKQDMARL-------LR-
------DYQELMSTK-------------------------------L-ALDVEIATYRRL
LEGEEYR------------MSGECPSQVTIS----------------T--VGGSSVM---
---TGG------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------A-GGGLVGTCGLASGRGGFGS-GCSSIV
TGGSGVIMGSG---------------------QGSMLGSCSVSGSGSGSGS--ISSSHTI
LKKTVESSLKTSVTY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------

------------------------------------------------------------
-------MSRQ-FTCKSGA------------------------------GNRGFSGCS--
AVLS-GG-------SS---SSY----RAGG------------------------------
-----------------------------------KGL-SGSFGSRSLYSLG-GA----R
SITLNMASG--SGK-NG------------------------GF-----------------
------------------------------------------------------GFGRNR
ASGFAGSIFGSVALG-PV---CP----AVCP-P-GG-I-HQ-VT----------V-NE-S
L--LAP-LN-VE-LD-PE-IQ-KVR-AQ-E------------------------------
------R-EQI-KA-LN-NK-FA-SFI-DK-VRF-LE---------------------Q-
QN-QV-LET-KW-EL-LQQLDL---NN--CKNNLEPILEGYISNMRKQ----LETLSGDR
-----------VRLDS-----ELRNVRDVVEDYKK--KYEEEINRRTAAE--NEF-VLLK
KDVDA----AYA-NKVELQAKVDSMD---QDIKFFKCLYEAEMA-QI-QSHISDMSVIL-
-SMD-------------------NNRNLDL--------DSIIDEVR-AQYEEIALKSKAE
AEALYQTK-------------FQEL-QL-AAGRHGD-DLKNTK--------------NEI
TELTRFIQRLRSE--I---------ENAKKQ-----------------ASNLET----AI
ADAEQRGDSALKDARAKLDEL---------------EGALHQAKEELARM-------LR-
------EYQELMSLK-------------------------------L-ALDMEIATYRKL
LESEECR------------M---SGEYP------------S-PVSISII---S-------
---------------------------------------------S--------------
-------------------------------------TSGSGGYG-FRP-----------
-----------------ST-------VSGGYVA---------------------------
----NSTSCIS-----------------------------------------GVCSVR--
--------GGESRSR-GSAS-----DYK-------DTL---TKG-------S--SLSTPS
KKGSR-------------------------------------------------------
------------------------------------------------------------
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Query Results

"ENSGT00910000144006_1"

ENSGT00910000144006_1