Query Results 

MALHCVHLFLLLLLSSW---WPDSEKHVVGAVKVREHYIAAQFTVWTY-KPESEEKSRLT
HLDPVFKKISYREYEVDFKKEKPADKS--TG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 202)

LLGPTLRAEVGDTLVVHFKNMADKPISIH
PQGLVYNKKAEGSLYADRTSHVEKQDDAVLPGQVYTYVWDITEEVGPREADLPCLTYAYY
SHENMVMDFNSGLIGALLICKKGSLNEDGSQKLFDKEYILMFGVFDENKSWQR-------
---------------SASLKYTINGYADGTLPDLEACMYDNISWHLIGMSSKPEIFSVHI
NGQVMEERHHRISTVNLVGGASTTVNMTVSEEGRWLISSL--VQKHL-KAK--MHGYLTV
RDCGDREVKKSRLSLKERRMIKNWEYFIAAE-----------------------------
---EVVWDYAPTIPDSLDKRYK-------AQHLDNYSNLIGKKYKKAIFRQYTDGSFTKR
LENP-RPKETG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 606)

ILGPIIRAQINDKVKIVFKNK-ASRPYSMYFHGVTLSK----NAEGADY
PQDPTGNATQSKGIQPGKTYTYEWQIAKTDQPTAQDAQCITRLYHSAVDIERDIASGLVG
PLLICKSEALSQKGVQKKADGEQHAMFAVFDENKSWYIEDNIKDYCSNPASVRRDDPKFY
NSNIMHT-----IN-------------------------------------G--------
--------YVSDR------NEILG-FCQDNVVQWHFSSVGTQDEVVSIRLSGHAFLYRGK
YEDVLNLFPMSGESVTVE----------MDNIGKRQDWLVRLQCLFDSSSKLCFK-PQSC
-----QENLELLSVAPDMYGALLAAQVFSTYIITCANTEALLVVLCVF------------
-------------DSQVTLVTVEQSGYTLPQVIGHLTAVKSATLNQVISL----------
------------------------------------------------VNLLLLEIGETM
QVFAVF-RLSFCILSLLLV---PKASIQQAKNLMPFNFKW--KTSSTNLKVLVIPPKPSH
LDAEKLKLLYYSINY-------HPLCIQKLLKY--HICQRFVYIVSQIALFRIFMCPALN
IGSSISFFFLFHIDLFHGILLIIFHCRLTLFYSGCCRKKKQQFSLTVYVIGSIHSHNTMS
YGMRLRFRDVRCDYEDDNL--FDVVDF---T-------NTKT--------DKKALSTSVE
EDVEEEAE--DDDSEYQDLLASFYSIRSLRNTGETEET---QNLTAMAWGQDG--DIDTA
SSK----------------LAIDSDLTVTNGS-----------KLTEFLETRIAPPLQVE
TE-------------------------------TFQSNYTSVTAEEYLLLASASDGKPDL
VF-----ENRSQ----------------------------------SDYA----------
V------------------------DHSNMSGGEHLLSN--------------GEAHVK-
--DAEEPLTDRK--------DSNFFTEEHQ-----------------EESAGKRNNSIN-
-------------SKRKKRSPLAVKFYMKA----LLD-----------------------
------------------------------------------------------------
--------------------------------------HHTENTSSTATVGAGQHPSDYD
DDLEEEETK----------------EGNAMHAGNLTLELEATVEENES-NTS--------
------------------------------------------------------------
--------------------------------------------------------RLSQ
LELSKDKQSDSFSLDQTLG--------------------------------------NIR
PNS------------------SPALVKNFLEAS--LPR------------A-V-------
--KYS----------------------------------------------------SKM
TDEEWNLVSAK-GIQRLEANLDKSV-----------------------------------
------SGKLNYGGRNG------TI-FLNKKH---------KKKDGEFSHLMGE------
-----------KHKGNHI---------------------------I-----SGTFVKIRR
KKKEYPKT-TQ--------------FLNPRSKKPQKFAKPTEEFGRTLFPGGANHESLPC
CN-TTES---------------PSYTQQLKPSIVI-GLPHE-NGNYE-YTSGEYYTEDTS
G---D--EYEYYYVSFDDPYMTDPKLNVNEQRNPDNIAEHYL-RS---RGNERRYYIAAK
EVCWNYAGLKKSTMM---Y-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DKICKDGSTKKVIF-QRYTDSTFTTVQDE
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2879)

ILGPVIRAEVNDVILVHFKN-LASRPYSLHAHGLFYEKSSEGSIYDDESSDW
FKEDDKVQPNSSYIYVWYANRRSGPLQPGAACRSWVYYS-DVNLEKDTHSGLIGPILI

ENSGT00910000143988_0_Linker_61_65 (2879, 2943)

CE
KGTFSASDNNRTNTRDFFLLFMVFDEEKSWYFDKRS--RKPCTEKTQEMQ------QCHK
FY

PF07731 // ENSGT00910000143988_0_Domain_65 (2943, 3040)

AINGITNNLQGLRMYEGELVRWHLLNMGVPKDIHVVHFHGQTFIEQLEA-KYQLGTYT
LLPGSFQTVEMKPQRPGWWLLDTEVGEYQQAGMQASYLV

ENSGT00910000143988_0_Linker_65_66 (3040, 3059)

LEKGCRIPMGMASGVILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
NASHHID-YWEPKLARLNNSGTYNAWSTTM-T---EDLPWIQVDFQRQVLLTGIQTQGAK
HFLKSFYVQKFFIVYSTDKRKWNTFRGDSSPAEKIFEGNSDAYGIKE-NIIDPPIIARYI
RVYPKQAYNEPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVDA--CSLPLGMENGEIKNT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSVKTSWFS----TW
EPSLARINQKG-KINAWRAKSNNNQQWLQIDLLTIKKITAIATQGVKSVTTENFVKTYVI
LYSNQGSEWKSYTEDS-SSVAKVFSGNEDSRGHVKHFFNPPILSRFIRIV-----PKTWY
NGIALRVELFGCDFGGDLTAKRTEKSGSS-------------------------------
-----

MFPGCPQLWVLVVLGTS---WAGWGSQEVDAARLRHFYVTAEAINWSY-YPQPPNP-SLN
PSTXXXXXXXXXXXXXXX-XXXXXXXX-XXX

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDTMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYLDHTFPEEKKDDAVVPGQEYTYEWTITEDSGPTQDDPPCLTHIYY
SYENLVQDFNSGLIGPLLICKKGTLLEDGTQRMFDKQHVLMFAVFDESKSWNQ-------
---------------SSSLMYTVNGYVNGTLPXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX-XXG--MQAYIDI
KNCK-KTRNPKKLTRDQR-HIKRXXXXXXXX-----------------------------
---XXXXXXXXXXXXXXXXKYR-------SLHLDNFSNQIGKLYKKVIYIQYQDESFTKR
LENT-DIQEDGILGPIIRAQVRDTLKITFKNT-ASRPYSIYPHGVTFSP----YEDEVNS
SSSSGS-NTMIRAVQP-ETYTYKWNILESDEPTGKDAQCLTRPYYSNVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMSNLTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDMLTIHFTGHSFIYGKR
HEDTLTLFPMSGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTLRSSSRS
QNIRLRFRDVKCIQND-DEDSYQI-IYEPTA----SS--------------SMATRK-MR
E---DKSEETDEDYDYQDKLALILGIRSLRNSSMTQEEDE-LNLTALALENDS--EFIHP
RANGAVGSNLSSPINISR---------------------LIDNDPSEPQKTLPHPGATPA
GPLLGNLSGLDKNSGLNPSTA---EYSIPYSEDPI-----------EDPLQSNVTGISLL
HH--SAEGFRGEDHDKHKGFKAGGQQAA-----------------RYKVSQMKIPAHKIG
RLLGQANT-----------------S-SRMRSLEDPPSDLLLLRQKNPSKVLNGKWHLVS
EKGSYEIIETNE---D--MTDKLLNNSQN--ASRTWE-E-I--LLTNKHGEQSGHLKFSG
VRHKSPPVRQSGGNSGLKKTSSLIKTRKKKNERKLTHYVPMSP-----------------
-----------------------------------------------------------R
GFHPLKGESHTTFSDRT-HDHSLLPHKYNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPTDLNQTFPFM-NAGLIDSLFD
QNENPQNDT-GQT

PF06049 // ENSGT00910000143988_0_Domain_6 (1814, 1822)

SIVPDLYQ

ENSGT00910000143988_0_Linker_6_7 (1822, 1846)

AMPPE-----EHYHTFPVEDPGQM

PF06049 // ENSGT00910000143988_0_Domain_7 (1846, 1868)

YLSTEPSH-------
-------

ENSGT00910000143988_0_Linker_7_8 (1868, 1869)

T

PF06049 // ENSGT00910000143988_0_Domain_8 (1869, 1877)

SSSPESNQM-LNHD-Q----FF--STDISQ-M-FPSLEL-EVRQT

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1923)

PISP-DL
SQ

ENSGT00910000143988_0_Linker_10_12 (1923, 1945)

TA--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-HSPELSQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

M

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELGQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

ILNPELNQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

TLSQ-----------ELNQ

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TDSPELSQ

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

M

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TISSELSQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

L

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

ILSPHLYQ

ENSGT00910000143988_0_Linker_21_37 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_37 (2029, 2313)

TTS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SEFSQ

ENSGT00910000143988_0_Linker_37_54 (2313, 2314)

T

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

NISPDDRQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

A

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDLS--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

A

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

TLLPDLG
QKPPLPNL-EQT-------------TYPTELSQS----LPLLEHGWT

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FP-------ST--
-----DLDQ

ENSGT00910000143988_0_Linker_60_62 (2410, 2769)

KP-SPPLSPTLNDTSIPRQFNPPVVV-GLTGD-NGDYIEIIPREEV-QSNE
E---D-SI-EMDFVNYDDPYQTDTRTDINSSRNPDHIAAWYL-RSN--NGNRKNYYIAAE
EIYWDYTKFSKS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--DAPEGTTYKKVVF-QKYLDSTFTKRDPR
SEYEEHHG

PF07732 // ENSGT00910000143988_0_Domain_62 (2769, 2802)

ILGPVIRAEVGDVVQVRFKN-SASRSYSLHTHGLSYEKSSEGKTYEDDSPEW
FKADNAVPPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKESNMPVDMREFVLLFMIFDEKKSWYYEKKP--KRSWTLASSEVK------NSHE
FHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXSFKTLEMKASKPGWWLLDTEVGEHQRAGMQTPFLIIDRXXXXXXXXXXXXXXXXXX
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00754 // ENSGT00910000143988_0_Domain_67 (3155, 3197)

YFDGNSDASTIKE-NQFDPPIMARYI
RISPTKSYNRPTLRLELQGCEVNG--CSTPLGMETRKIENKQITASSFKKTYFG---NSW
EPSYARLNTQG-RVNAWQAE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----

MLPVCPRFFLLVVLGTR---WAGWGSHQAEAARVRQFYVAAQGILWNY-HPEPTDP-SLN
S-IPSFKKIVYREYEPYFKKEKPR

PF07732 // ENSGT00910000143988_0_Domain_0 (85, 201)

ASN--SGLLGPTLYAEVGDIIKVHFRNKADKPLSIH
PQGIKYSKFSEGASYPDHTSPAERKDDVVAPGEEYTYDWIVSEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTINGFVNRTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGKWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPANMDKIYR-------SLHLDNFSNQIGKHYKKVIYRQYEEETFTKR
TDNP-SIKQS

PF07732 // ENSGT00910000143988_0_Domain_3 (491, 567)

GILGPVIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGN-HTMIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDQRGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRR
HEDTLTLFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPKR
RNLRLRFRDVKCIRDYDNDDSYE--IYKPLA----PT--------------SMTTRK-IH
DSLENELGADDEDYDYQSILASSLGIRSFRNSSLNPEENE-FNLTALALENSS--EFISP
STDRVVDSNS--SRILSK---------------------FTSNNLKGSQRTHPGSGATVA
GTLLGNLIGLDENFVLNPSIE---HRSSSYHENAM-----------ENP-QSNITVVYLL
PL--GPKGSGSREQAKPKTIKTGRPHMM-----------------KHRFSWMKAPAGKTG
RHSNPKNT------------------YSRMKSEEDIPSDLLLLKQNITSKFLNRRWRVAS
EKASYEIIPANG--EDT-DVDKLTNSPQNQNITMPWG-EST--AHTNTTRKPSNLPTFSG
VRHKSPRVRQEEENGGFQKRQLFIRTRKKKKNKKLALHSPLSP-----------------
-----------------------------------------------------------R
GFYPLRGDDHLPFSDRRLLNHSLLLRKFNDTA-----LSTDLNQTSPSM-SMDR--SFPD
YNQYASNDT-EQMSSSLDLYQSVPPV-----EHSPTLPAQDPDQTHSTTDPSY-------
-------RSSPPEHSQG-LDYD-LS-HEFD--PDDIGQ--------------TSFFP-NQ
SQKS---------------------SLSSDDDQEIPSSDLTLFTISPELDQTIIYPDLDQ
LLISPDDNQ--NTS----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------S--PDLGQVPLFPD-DNQ-NY----------FLD
LGQIHLSSDQNQETSSTDLSLLTLS---------PDFGQ--TVLPPDLDQLPLS-SDN--
G----------QVTLSPDLSLLTLSPD--FNEIILSPDLGQVTLSPDLI--QTNPALNHQ
HKTSSADP-DQA-------------SYPPDSGQA----SSLPELNQTLP-------HP--
-----DLIH-IPPPLPSPTLNNTSLSRKFNPLVVV-GLSRV-DGDDVEIVPSEEL-QRID
E---D-YA-EDDYVTYNDPYRTDIRTDVNSSRDPDTIAAWYL-RSH--GGNKKFYYIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------HEDIG--HTAKDTTYKKVVF-RKYLDSTFARRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKIYDDESPEW
FQEDDAVQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHRESNLPMDRREFVLLFMVFDEKKSWYYEKS---KGSWRIESPEAK------NSHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLDNRTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLT-YWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAK
HYLKSCFTTEFQVAYSSDQTNWQIFRGKSRKNVMYFTGNSDASTIKE-NRLDPPIVARYI
RIHPTKSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGLEDGRIQNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSI
QYSDQGVAWKPYRQKS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFSGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYLAAQGISWSY-RPEPTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSTI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSIGEDSGPTHDDPPCLTHIYY
SHENLIKDFNSGLIGPLLICKKGTLTEDGTQKMFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEDEESDADYDYQSRLAAALGIRSFRNSSLNQEEEE-FNLTALVLENGA--EFISS
NTDIIVGSNYSSPSNISK---------------------LTVSNLAEPQKTPSHQQATTA
SSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKRKGPKVERDQAA-----------------KHRFSRMKLLAHKFG
RHLSQDTRSPSGMRPWEDLPSQDTGSPSRMKPWEDPPSDLLLLKQNNPSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLVNKPGKQSGHPKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTYHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERT-LKHSLLLHKSNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPTDLNQTLPSV-DFGWIASLPD
HNQNSSNDT-GQTSSPRGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------RSSSPELSEM-LEYD-QS-HKSF--PTDISQ-M-SPSSEH-EVWQTI

PF06049 // ENSGT00910000143988_0_Domain_10 (1915, 1923)

TSP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPELSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

LSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALGQ
MPISPDLNLSHT

PF06049 // ENSGT00910000143988_0_Domain_17 (1993, 2001)

TLSPDLSH

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TLSPDLSH

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

T

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLSH

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLSH

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TLSPDLSHTTLS
LDLSQTN

PF06049 // ENSGT00910000143988_0_Domain_24 (2048, 2055)

LSPELSH

ENSGT00910000143988_0_Linker_24_27 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2056, 2084)

TL-------------------SP-ELSQTNLSPALGQMPISPDLN
LS---------------------------------------HT-----------TLSLDL
SQTN---LSPEL-------KLSQTNLS--PALGQM

PF06049 // ENSGT00910000143988_0_Domain_40 (2196, 2206)

PISPD-FSH-TTLSLDFSQTN

PF06049 // ENSGT00910000143988_0_Domain_43 (2217, 2224)

LSPE
LSQTNP------------------SPALG---------Q--MPLTPD----------L--
D----------QM

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2302)

TLSPDLGE

ENSGT00910000143988_0_Linker_51_52 (2302, 2304)

TD

PF06049 // ENSGT00910000143988_0_Domain_52 (2304, 2313)

LSPD--FGQ

ENSGT00910000143988_0_Linker_52_54 (2313, 2314)

M

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

SLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2329)

TLSPDI

ENSGT00910000143988_0_Linker_55_56 (2329, 2337)

S--DTTLL

PF06049 // ENSGT00910000143988_0_Domain_56 (2337, 2342)

PDLS
Q

ENSGT00910000143988_0_Linker_56_57 (2342, 2343)

V

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQI-------------FYPSESNQS----LLLPEFNETFP-------YP--
-----DLGQMP-SP-LSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEETTYKKVVF-RKYFDSSFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMT------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLPAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSSQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MSPGCPRLWVLLVLGSS---WAGWGAPGAEAARLRQFYVAAQGISWNY-HPEPTNP-SLN
PFATTFKKIVYREYEAYFHKEKPQSKT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDIMRVHFKNNADKPLSIH
PQGIKYSKSSEGASYSDHTFPAEKLDDAVAPGHEYTYEWTISEDSGPTKDDPPCLTYIYY
SYENLIQDFNSGLIGPLLICKKGTLTEDGSQKMFDRQQVLMFAVFDESKSWSR-------
---------------SSSVMYTVNGYVNGTMPDITVCAQDHISWHLIGMSSGPELFSIHF
NGQVLEQNRHKVSAVTLVSATSTTANMTMGPEGKWIISSL--IPKHF-QAG--MQARINI
ENCAKKTRSPKWLTPEQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPFIPVNMNKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDETFTKR
LEES-RNIEDGILGPIIRAQVRDTLKITFKNM-ASRAYSIYPHGVTFSP----LEEKVNS
SSASGS-NTMVRAVQPGETYTYKWNILESDEPTDKDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDTRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPDS------ISILG-FCFDDTIQWHFCSVGTQDDFLTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWILTTMNSNPRS
KNLRLRFRDAKCNRNDEDEEYDFE-IYKPPP----ST--------------PMTTRK-VH
EFPENQGEIDETEDDY---LASLYGIRSFRNSSLNQEEDE-FNLTALALENTS--EY---
------------------------------------------NKFAEPNKTLPHPETTTA
GPQVGH--SLEKSSVLGPSTA---ENSRPYSEVPI-----------EDPLQPKVTGTSLL
PL--GAEGFRSQGNAQHKGL------EA-----------------RHRFSRMKFLGHKTG
RYLSQGNS-----------------S-SIMEPWKDLPSDLL--KHKTLSKNLNGKWHLVS
EKGSYEIIPEAD--EDM-AVNKLRNSPQT--ASRTWG-ERI--PLTNKHGEQGGHPKFPG
IRHKFLQTRP-GGSSRVKNSTFLIRTRKR----KPAHHTPLSP-----------------
-----------------------------------------------------------R
NFPR--GEGNLTLPD--------ALHKVKETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPTDLAQTLPRG-NLSLVASLPD
HNLSLPDST-GQT

PF06049 // ENSGT00910000143988_0_Domain_6 (1814, 1822)

SFSPDMYQTMPPE-----QFYQMFWSQDSDQTQFPPSPSH-------
--------AASPEPGQM-PDYD-GG-TQSF--PTNTGQ-G-SPSLER-EVWQT

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1923)

AIPP-EL
SQ

ENSGT00910000143988_0_Linker_10_12 (1923, 1945)

TT--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LSPDIGQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDIGQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

TLSPDLGQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2010)

TLSP--------------------DLGQ

ENSGT00910000143988_0_Linker_17_20 (2010, 2011)

T

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLGQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLGQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TLSPDIGQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLGQ

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDIGQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

M

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TLSPDIGQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

T-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DLGQ

ENSGT00910000143988_0_Linker_28_30 (2084, 2085)

M

PF06049 // ENSGT00910000143988_0_Domain_30 (2085, 2224)

TLSPDLG---------
------------------------------------------------------------
------------------------------------------------------------
--Q

ENSGT00910000143988_0_Linker_30_44 (2224, 2225)

M

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

TLSPDLDQTTLSPD------------------------------------------
-----------------------------LSQE

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

TLSPDFRH

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

A

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIT--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

T

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

GLPPDLR
Q

ENSGT00910000143988_0_Linker_56_57 (2342, 2343)

T

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-GQT-------------AYISESSPS----SPLPEFDPTFP-------YS--
-----DFGQMP-SPQPSPSLNNTSIASEFNPPIVF-GFSGE-DGEYIEITPREKQ-QSSE
E---D-VY-EIVTVTFNNPYQTDIRTDINSSRNPDRIAASYL-RSS--NGNRKYYYIAAE
EISWDYAKYAQS---DMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--EVPEDTIYKKVVF-RKYLDGTFTQRDPQ
GESEDHLGILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKNYEDESSKW
FQEDNAVQPNSSYTYVWHAIGRAGPENPGSACRAWAYYS-AVNTERDIHSGLIGPLVICR
KGTLNRESGMPVDMREFVLLFMVFDEKKSWYYEKKH--QSSWRSGSSEAK------PSHT
FHAINGMIYKLPGLRMYEQEWVRLHLLNVGGSRDIHVVHFHGQTLLENGGDHQLFIFTHN
LVPGSFKTLEMKASKPGWWLLNTEVGENQVAGMQTPFLIIDRECKMPLGLSTGLIADT

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFVG-YWEPKLARLNNGGSYNAWMTEKTS-EFYSKPWIQVDMQREVVFTGIQSQGAK
HYLTSYFTTEFCVAYSSDQTNWQIFKGNSTRNVMYFDGNSDASTVKE-NLFDPPIVARYI
RVYPTRFYHRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEING--CSTPLGMESGKIEDA

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWR---DYW
EPSRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVRSYAV
HYSDQGVEWKPYRQKS-SMVDKIFEGNSNIKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFAHCHPFWVLVVLGTS---WAGWGNKEAQAAQLRQFYVAAQVISWNY-RPQPTDS-SLN
TSETFFKKIVYREYEAYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDTMKVHFKNKADKPLSIH
PQGIKYSKFSEGAAYPDHTFPVEKMDNVIAPGQEYIYEWKITEDSGPTHSDPPCLTHIYY
SYENLVQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLMFAVFDESKSWIQ-------
---------------SSSLMYTVNGYVNGTLPDITVCALDHISWHLIGMSSGPELFSIHF
NGQVLEQNNHKVSAIILVSATSTTANMTVSPEGRWAISSL--IPKHF-QAG--MQAYINI
ENCPKKTRSAKKLTRDQRRYMKRWEYFLAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLENFSNQIGKYYKKVVYRQYEDETFTKR
TESP-DVQRDGILGPIIRAQVRDTLKIVFKNK-ASRPYSIYPHGVTFAP----YEDEVNS
SPSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXRAADTEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMSNLTLSAIN-------------------------------------G--------
--------YVPES------IRTLG-FCFDDTVQWHFCSVGIPDDILTIHFTGHSFIYGKR
HEDTLSLFPMRGESVTVT----------MDNVX---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-----X--------------XXXXXX-XX
XX--XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXVVGSSSSPSNVSW---------------------LIDNDLSKPQKTLPHSRIAAT
GTLLGYLTGLDKNSAVNPTSA---KHSSLYPE--------------EDPLQSDVTGISLL
PL--AVHRFRSQKHAKYEGLKAERDQPA-----------------KLGLSQ-KLPAHKTG
RHLRQGNI-----------------SNSRTGPWEDLSSNPLLLKQKNPSKILNGKWHLFS
EKGSYEIIQENE--ENM-TFNMLPSSPQN--GSNTWR-GST--PLINKHGKQSGQPGFSE
LSHKFLQVRQDRESHGLKKTSAYIKTRKKKQ--KLRHRVSMSP-----------------
-----------------------------------------------------------R
GFHPQREEAYTTFSDRK-LDDSLLLRKSNETS-----LITDLSQTLPST-NPALIPSLPH
HDQNSPNDSTHQTSSPSDLYQTIPPE-----EHSH---IQDPLQTHSPTDSNH-------
-------RPFSSELEEM-FKYD-LT-YETS--PDDDGQ-M-FPSLEL-EVRQITTSP-YR
SEPS---------------------ISPDLSQMTLSPE-----DLSSEVSQITLSPDFSQ
PSLSPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------XX----------
-XXXXXXX-----XXXX---XXXXX---------XXXX-XXXXXXXXXXXXXXXXXXXXX
X-X------XX--XXXXXXXXX--XXXXXX-XX---------------------XXX-X-
XXXX---XXXXXXXXXXXXXXXXXXXX--XX-XXXX--XX-----------------X-X
XXXXXXXXXXX---XXXX-XXXXXX---------XXXXX--XXXXXXXXXXXXX-XXX--
---------------XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX--XXXXXXXXX
XXXXXXXX-XXX-------------XXXXXXXXX----XXXXXXXXXXX-------XX--
-----XXXXXX-XXXXXXXXXXXXXXXXXXXXXXX-XXXXX-XXXXXXXXXXXXX-XXXX
X---X-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX--XXXXXXXXXXXX
XXXXXXXXXXXXXXXEID------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--EAPKNTVYKKVVF-RKYLDSTFTKYDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_63 (2769, 2802)

LLGPIIRAEVDDVIQVRFKN-LASRPYSLHVHGLAYEKSSEGKTYEDDSPEW
FKKDNAVQPNDTYTYVWHATERSGPETPGSACRAWAYSA--VNPXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX-XXXXXXXXX------XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXGSFKTLEMKASKPGWWLLGTAVGENQQAGMQTPFLIVDRECKMPMGLSTGMISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPKLARLNNGGSYNAWSIEKVSRELGSRSWIQVDMQRQVVLTGIQTQGAK
HYLKSYYTTEFYVAYSSDRASWKIFKGNSTRSMMYFDGNSDASTVKD-NKFDPPIVARYI
RVSPTRAYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3316)

QITASSFKKSWWG---GYW
EPSLARLNAQG-RVNAWQAQSQNNRQWLQIDLLKIKKITAIVTQGCKSLHTEMYVKSYAI
HYSNEGVEWKPYRQEF-SMVDR--------------------------------------
------------------------------------------------------------
-----

KRILSSSLFILFLLGTV---LQS---APKVSAAVREYYIAAVITDWSY-TNQYHDSS--N
RYKFLYKKIIYREYEEGFQKAKPAVEY--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

ILGPTLRAEVGDILQVHFKNMANKPLTIH
PQGVAYGKKSEGAKYTDSTLPYEKLDDSVMPGQMYTYIWEITEEIGPKEYDPACLTNIYY
SHENMVQDFNSGLIGALLICKKGSLNEVGEQRHFDKEYVLMFAVFDENKSWQNLN-----
-------------DKEHSVMYSINGYVNGTIPDIYACAGDSVSWHLLGMSSEPEFFSIHF
FGQTLEENQHKVSVVGLVASSSTTANMTIYQTGKWLITSL--VEKHFEEAG--MHGYIEV
QPCSDKGYTAPKLSLLQKRFIKVWEYFIAAEEEEWNYVPSKVENTDKLP-----------
------WFKCFTI------------------VLCTNRINCQQKYKKVLYKAYSDNTFTKL
LTA----GNEGLLGPVIRAQVRDTITVVFKNK-AKRPYSIYPHGVSVQK----AYEGASY
PPDIRGNETQNQAVMPGETVTYYWNILETDEPAARDPRCLTRMYHSAVNITKDIASGLIG
PLLICKSMSLNTRGVQEKADLEQIATFALFDENKSWYHNENKLKHCH---AVNNDQTEYY
SHNIIPT-----IN-------------------------------------G--------
--------YA-FE------SAPLG-FCHSQVIHWHISSVGAQDEIIGVHLSGHTLRYKGK
SEDTVNIFPMSGESISVD----------MDNLGLWLFGVFGSSKKNQGLKVRFTDVICVE
----EEEDYEEPNIQFGISSEEI-----TKKIVTSPETD---------------YSEEED
V--------------NTNLDI-DY-TDNL-ADLFHIRSFRNKTET---------------
----QEEG----------------------------------------VNLTALAIEHTY
GRQNE------SMGDFSKLEVSEEYDIVPIEDNENSNFNPTSASKADKLTKDGLPKTPQY
MQS--------------KDE----DTLENTLSEESNMAQKNV------TV----------
-------------------------------YNPLDSEKEQFIIMEGN--------LTTD
-----KNRDLS----YDSY--FNEADKNIYSEEDKAKMITEQNTSNLLAESKPQLSNTEK
SHFIKEDL------SHSINKTFYYLVTTYDNDTQNSET---QHNEFMALKVAE--KIIDT
HQK--------VPRQEEKMTEISDHVTTVENNTLDITKHDFPLREDLFNATDSKEYNPQ-
------VADIKEKKLVKRSIE----HM--------TESPTYSPLNVDHFLETEN------
------------------------------------------------------------
-------------------------EKSHSSDNKDIMDD---------------------
----------FSTNQGLDSNDTFNDFIKNQ--------------------TSESNYNT--
------------------------------------DNISKNQTVASSDIT---------
------------------------------------------------------------
----------DDFSKNGTTKN-LL-SSTNITS-GIKELHSSKNNDLTDYLDHDKTPEKLI
PYFNDSNLNLLPNRTSHSLEESKLPNGNSNNYGNQTAATR---DIDS----PE-------
-------TKSDTEFREL-FGSNEVT-NDNF----K-------------------------
--------------------------------------------------RDSTHLCLGG
LELLKNVA--QITLSKTVARIPLVADLNQ------------------KIYKQSEYTGKQI
PLG------------------KSENHPNVLEQA--LSR------------GND-------
--PGTRDLGRVIKVTEKKAQQ----------HLSLLKEKEGLK--GSSQRAPQCNLLPAS
SCLLWVWMCSN-VNKGVLPNDYT-V-----------------------------------
--------NSPDISRQTDFTAINLF-FFL-----------------AFFLLSKK------
-----------EVNETNME------QH-----LV-------------TEENSTEMRPIRY
RTSSNE----TR-------------MLTRRK-----------------------------
----KRLGNVNGSLSNDTGNDGVFSPRGMRPQIII-GLPGLDEGDYVELNVDEID-----
----E--DVHIKKVEYEELYKT----EAQEYTNPDKIIQQYL-RSL--KGKKRKYYITAE
EEQWDYYNPAKSSLTKERP-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DSETRTTQYTKVRF-RQYLDSSFSKPDVQ
GEYEEHLGILGPVIRAEVDDIIQITFKN-LASRPYSLHAHGVSYEKSSEGFQYDDGTPDW
LKKDDAVKPGETYTYVWYATHQSAPENEGSDCRTWIYYS-GVNPEKDIHSGLLGPLLICK
SGTLHKHSNRPLDVREFVLLFMTFEEEKSWYFEKNK--KKTCLEVM

PF07731 // ENSGT00910000143988_0_Domain_65 (2927, 3043)

EKPL---QAAKCHT
FHAINGKIYNLKGLVMYQNESVRWHMINMGGSKDLHVVHFHGQTVTERINR-ESQRGVYP
LLPGSFATVEMKPSKPGHWLLDTEVAEYQQAGMQAMFHIVEA

ENSGT00910000143988_0_Linker_65_66 (3043, 3059)

ECNLPMGLSNGIISDN

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
TASHYID-YWEPRLARLNNAGSYNAWSTVMNM---SALPWIQVDLQRPFLITGIKTQGAS
KYLKPYYVKEFFVVYSLDKKNWIAFKGNSITLQMFFDGNTDAHSIKE-NTLDPPISAQYI
RVYPTKYYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3230)

LFGCEILD-TCSVECVLW-GV----KAQHHSGS

PF00754 // ENSGT00910000143988_0_Domain_68 (3230, 3369)

TIWFPKCQSHW
LIALTMLNGPTHFHKEWNVKSNNNQQWLQIDFLMTKRITGITTQGAKALTTDMYVKSYSI
QYSDNGKDWKPYTDEL-APLEKVFLGNANSYGLVKNEIRSPILARFLRII-----PKSWH
NSITLRIEIFGCNI----------------------------------------------
-----

----------------------------------------------------------LN
PFATSFKKIVYREYEPYFKKEKPRSSI--SGLLG-TLYAEVGXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXTLTEDGTQKMFDKQHVLLFAVFDESKSWSP-------
---------------SSSLMYTVNGYVNGTMPELVVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKVSTVTLVSATSTTANMTVSPEGKWVIASL--IPKHF-QGT--LTAYIDI
KNCSKTVEIKK--ATRQMSHIKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLDNFSNQIGKQYKKVVYKQYQDETFTKR
MENQ-NNEEYGILGPIIRAQVRDTLKIVFRNM-ASRPYSIYPHGVTFSP----HEDEANS
SFSAAGSTSMIRAVQPGETYTYKWNILEFDEPTEYDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDKRGIQRAADTEQQAVFAVFDENKSWYLEDNINKFCENPEEVKRDDPKFY
ESNIMSNFALSAIN-------------------------------------G--------
--------YIPDS------ITPLK-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVS----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRG
KNLRLRFMDAKCRWDDDEDDSYE--IYKPPS----ST--------------AMATRK-MR
DSSENYDEDNDTENDYQDTLAELLGLRSFRNSSLNQEEEE-LNLTAIALENSS--EFISS
STDTAVVLNSSSPAKRGR---------------------PISRDLTESQKTLALPGAATD
GALRGDLIGSDKNSLLSPSTA---RHSSSFSENPT-----------EESLQSDVAKTRHP
LL--GTKGVRSHGRAER---RKERGWAA-----------------QHRFSR------ITG
RHVSQDDV-----------------SHSGIGSLEDLPSDLLIFKQKDPSKTLNGKWHLVF
EKGSYEIIQDTD--EDT-GANK-LNSPQN--ASRTWG-ESI--PSTNKPGKQRDHPESSR
VRRKSR-GRQERVNSGLKRRPFFIKTRKKKKEEKPGHHVPLSP-----------------
-----------------------------------------------------------R
GFHPLRGEAYSTFSDRR-LDHSLLLPKSNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPTDLNQTFPIT-DLDLIYSLPD
HKQNPPNNT-GQTSSPTDISQTVPPE-----EYYQISPVQNPYQMHSATDP---------
--------------SQM-LEYD-LS-HK

PF06049 // ENSGT00910000143988_0_Domain_9 (1889, 1900)

SF--YTDIDQ-

ENSGT00910000143988_0_Linker_9_10 (1900, 1914)

T-SPSLEH-DVWQT

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1923)

TLSP-DL
SQTS---------------------PSLD----------LSSS

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDFSQTSSSLDLS-
------------------------------------------------------------
------------------------------------------------------------
---------QT-SHFPD-------------------------------------------
---------------

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

-LSPDLSP

ENSGT00910000143988_0_Linker_38_39 (2184, 2185)

T

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

TLS--PNLGQ

ENSGT00910000143988_0_Linker_39_47 (2195, 2196)

T

PF06049 // ENSGT00910000143988_0_Domain_47 (2196, 2302)

SP-----------------------
------------------------------------------------------------
---------------FPELSP

ENSGT00910000143988_0_Linker_47_52 (2302, 2303)

T

PF06049 // ENSGT00910000143988_0_Domain_52 (2303, 2322)

TFSPD--FN---------QKSSSPDQ------------
-T

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2351)

PPPPNLNQTT-------------SYPPESSQS----PLLPEFSQS

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

SP-------YP--
-----DVGQMP-SPPTTSIINGTVPSSEFNPLVVV-GLSGV-DGDYIEIIPREEV-QSGD
D---D-YV-EIDYVAYDDPYQTDIRADINSSRNPDNIAAWYL-RSN--NGNRKYYYIAAE
EVSWDYSKFVHS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------HEDSD--DTPEDTIYKKVVF-RQYLDSTFTKRDPQ
GENEEHLGILGPVIRAEVDDVIQVRFKN-LASRPFSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERAGPESEGSACRAWAYYS-AVNPEKDIHSGLVGPLLICR
KGTLHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX------XXXX
XXXINGRTYNLPGLRMYEQEHVRLHLLNLGGARDIHVVHFHGQTLLENGNQQH-QLGVWP
LLPGSFKTLEMKASKSGWWLLDTEVGENQQAGMQTPFLVIDRDCKMPMGLSTGVVADA

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLS-HWEPRLARLNNGGTYNAWSTERPASGLGSTPWLQVDMQKEVVITGIQTQGAK
HYLKSYYTTEFTVAYSSDYTSWQIFKGNSMRNMMYFDGNSDASSIRE-NKFDPPIVARYI
RISPTRFYNRPTLRLELQGCEVN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----

MFPCCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQILLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EIIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVTATRK-MH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNTSK---------------------LTVNNLAEPQKTPSHRQATTA
GSSLRHL--TGKNLVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHKGPKVERDQAA-----------------KHGFSWMKLLAHKVG
RHLSQDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSPKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPEKQSGHSKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQIEPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------R

PF06049 // ENSGT00910000143988_0_Domain_8 (1869, 1877)

SFSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTVT

PF06049 // ENSGT00910000143988_0_Domain_10 (1916, 1923)

SP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPELSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALDQ
MPM

PF06049 // ENSGT00910000143988_0_Domain_17 (1984, 1992)

SPDL--SHTTLSPDLSHTTLSLDLSQTN

PF06049 // ENSGT00910000143988_0_Domain_20 (2012, 2019)

LSPELSQTNLSPALGQM

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

PLSPDLSH

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLSH

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSADFSH

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSPDLSHTTLSLDLNQT-N

PF06049 // ENSGT00910000143988_0_Domain_28 (2076, 2084)

FSP-ELSQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2086)

TN

PF06049 // ENSGT00910000143988_0_Domain_26 (2086, 2093)

LSPDLSE

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

M

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

PLSPDLS
HTTLSLDLSQT-N

PF06049 // ENSGT00910000143988_0_Domain_33 (2114, 2121)

LSPELSQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2125)

TN--

PF06049 // ENSGT00910000143988_0_Domain_34 (2125, 2133)

LSPDLS-E

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

M

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2143)

PLSPD-LSH

ENSGT00910000143988_0_Linker_32_36 (2143, 2155)

T-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDF
SHTT---LSLDLSQTN

PF06049 // ENSGT00910000143988_0_Domain_38 (2177, 2184)

LSPELSQTNLS--PTLGQM

PF06049 // ENSGT00910000143988_0_Domain_40 (2196, 2206)

PLSPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
LSH

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

ILSPDLSHTTLSLDLSQTN

PF06049 // ENSGT00910000143988_0_Domain_47 (2244, 2251)

LSPELSQ

ENSGT00910000143988_0_Linker_47_49 (2251, 2253)

TN

PF06049 // ENSGT00910000143988_0_Domain_49 (2253, 2259)

LSPDFS

ENSGT00910000143988_0_Linker_49_50 (2259, 2263)

E--M

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

PLSPDFSH

ENSGT00910000143988_0_Linker_50_48 (2271, 2272)

T

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2293)

TLS-SDL--
S----------QTNLSAELSQTNLSPA--LRQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQVTVSSDIS--ETTLLPDFS
QMSPPLDL-DQI-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATDRSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGAFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFRVCPRLCILVVLGTS---WAGWGSHRAEAARVRQFYVAAQGILWSY-HPEPTDP-SLN
S-KPSFKKIVYREYEPHFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTMKVHFKNKADKPISIH
PQGIKYSKFSEGASYLDHTFPVEKMDDAVDPGGEYTYQWVISEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTVNGYVNRTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTITLVSATSTTANMTVSPEGKWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRNPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPANMDKKYR-------SLHLDNFSNQIGKQYKKVIYRQYEEETFTKR
MENA-NIKQSGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEGNS
SSTPGS-HTMIRPVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDITRDLASGLIG
LLLICKSRSLDQRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTYDDVLTIHFTGHSFIYRKR
HEDTLTLFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRR
KSLRLRFRDVKCNRNEDDEDSYE--IYEPSA----PT--------------SMTTRKIIH
DSSEKDFDLDNEDDDYQYLLASSLGIRSFRNASLNQEEDE-FNLTALALENSS--EFIFP
NTDRVNDSKS-SPKNLSG---------------------ITGNNLKESQRTPPGSGATMT
GTLLKDLTGLDENSVLNPATE---HHSSSYYESDV-----------EES-QSDITVVHLL
PL--GTTGSGSQEHAKHKKAKSERPLLV-----------------KHRFSHMKVPARKTG
RLSNPKNT------------------YSRKRAREEIPIELFLLKQKNTSTFLNREWYLAS
EKGSYEIISVNG--EDT-AVEKLPNSPQTQNISKTWG-DST--SPTKTAGKQSDLPVFSR
VSHKSPRVRQEEGNSDLKK----IRTRKKKKNKRLSLHSPLSP-----------------
-----------------------------------------------------------R
GFHPLKGDAQATFLDQI-LNHSLLHNKTKKSV-----SALDLNQTSPST-SIDR--SLPD
HNQTSPHDT-KQKSSAFDLYQSVPPE-----EHSPPFPVQDPDQTHSATDHSH-------
-------RSSLPQPSQE-LDYD-LS-HESY--PEDTGQ--------------TSFFP-KQ
SQKF----------------------LSSEDGQTSPSSDLSLFTVSPELVQTIISPDLGQ
MPLSPGDNQ--ITSPQDLGQVPLSPGDNQMTSLQD-------------------------
-----------------------------------------------LDLGQVPLSPGDN
QMTSPQDLGQV-PLSPDDNQMT--SPQDLG-QVPL-------------------------
------------------------------------------------------------
------SD-STQKSSQQDLSLLTLP---------PEFDE--VALSQDLDEMPFS-SDF--
S----------QVTLSPDLSPLTLSPD--FDEIIISPDLGQVTLSPDLI--LTSPPLNHR
HKMASSDP-GQA-------------SHPSDSGQS----SPLPELNQTLP-------DL--
-----VHMP---TPLPSTTLNNTSVSEEFNPLVVV-GLSRV-DGDDIEIIPNEEL-ESID
D---D-YA-EDDYVTYSDPYKTDTRTNINSSRNPDTIAAWYL-RGH--GGNKQYYFIAAE
EVSWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--AVPKDTTYKKVVF-RKYLDSTFTRRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAVQPNSSYTYVWHATQRSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHPKSKLPMDMREFILLFMAFDEKKSWYYEKS---KRSWRIESPEVK------NSHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSQDIHVVHFHGQTLLDNSTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQIAGMQTPFLIIDKGCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASGHLN-YWEPKLARLNNGGSYNAWSIEKSALDFAFQSWIQVDMLKELVVTGIQTQGAK
HYLKSCFITEYNVAYSSDQTNWQIFRGNSTKNVMDFAGNSDASTIKE-NQFDPPIVARYI
RIHPIKSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSMPLGLEDGRIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
DPSRARLNAQG-RVNAWQAKANNNKQWLQVDLLKIKKITAIVTQGCKSLSSEMYVRSYSI
QYSDQGVEWKPYRQRS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFLACPGFWVLVVLGTS---WAGWGNLGAEAARLRQFYVAAQSIRWNY-RPESTHL-SSK
PFETSFKKIVYREYEAYFQKEKPQSRT--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKAHKPLSIH
PQGIKYSKFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWSISEDSGPTHDDPPCLTHIYY
SYVNLVEDFNSGLIGPLLICKKGALTEDGIQKMFDKQHVLMFAVFDESKSWNQ-------
---------------TSSLMYTVNGYVNGTIPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNRRKISAITLVSATSTTANMTVSPEGRWTIASL--IPKHF-QAG--MQAYIDI
KNCAKKTRNPRKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPASMDKKYR-------SLHLDNFSNRIGKHYKKVVYKQYQDDSFTKR
LEDP-SSEGDGILGPIIRAQVRDTLKIVFKNM-ASRAYSIYPHGVTFSP----YDDEVNA
SSTSGS-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDVTRDLASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNDLLTIHFTGHSFIYGKR
HEDTLTLFPMQGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KKLRLRFRDAKCIRND-DDDSYEI-IYEPSG----ST--------------AMTTRK-MH
DSSEIK-DENDADSDYQEELASILGLRSFRNSSLNQEKDE-LNLTALALEKDS--EFIPP
STNRDLGSNSSSPRNVSR---------------------LIANNFAEPLKTLLHLEAPAA
GPALEH-AGLDKNSTLNPPMA---EHSSPYSEDHR-----------EDLPLSDVTGISLL
PF--GT-GFKNQKPAKHQRFQVGRGRAA-----------------KHRFSQTESPAHKTR
THLSQDNS-----------------SSSRMGLWEDIPSDLLLLQQKDPSKILNGEWYLVS
EKGSYEIIQDAN--ENK-TVNKLPNSPQN--ASRTWG-ENI--PFKNSHGKQSGHPTFLV
TRRKPLQDRQDRRNSRLKEGLPLIRTRRKKKEEKPAYHVPLSP-----------------
-----------------------------------------------------------R
SFQPLRGEVNASFSDRR-HNHSLLLHASNETY-----LSIDLNQTFPSM-NLSLAASLPD
HDQTSPNDT-SQTSSPPDLNLTVSPE-----EHYQTFPIQDSDPTHSTT-----------
---AHSNRSPPTQPSQI-PNYD-LR-NQAI--PTDVSQ-I-FPSLEP-EVWQTATSL-DL
SQPS---------------------ISPDLGQ----------MAPTPDLSQESLSPDLGQ
TDLSP-----------DLSQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------ESLSPD
LGRTALSPDLSQESLSPDLGQ---------------------------------------
--------------------------------------------------------LDLK
QTSPPLDL-DQT-------------SHTSESSQS----LSLPEFGQTFP-------YA--
-----DIGQMP-SPPPDSTLNNTFIPEEFNPLVVV-GLSRD-DGDYIEIIPGQKE-ESSE
E---D-YG-EFEFVAYNDPYQTDLRTDISSSRNPDNIAAWYL-RSN--NGNRKNYYIAAE
EISWDYSKFVQS---EDT------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------D--DVPEHTVFKKVVF-RKYLDSTFTKLDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNSTYTYVWHATTRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKETNMPVDMREFVLLFMVFDEKKSWYYDKKP--TRSWRHTSSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LMPGSFKTLEMKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
QASEFWG-YWEPKLARLNNGGSYNAWIAEKLSTEFNPQPWIQVDMQKEVLLTGIQTQGAK
HYLKPYYTTEFCVAYSSDQKNWRIFKGNSTKNVMYFGGNSDASTIKE-NQIDPPVVARYI
RISPTRSYNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3345)

QITASSFKKSWWG---NYW
GPFLARLNAQG-RVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMDWKPYREKS-SMVDKIFEGNNNVRGHVKNFFSPPIISRSSMKYIQYGLTRTWC
CCFLCSLPQTTSAISLSFCSRDSALLLRGSCCSMPRDCWPFSSWNSSMASPLPLKLPTTP
TSTVW

MFPGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNS-SLN
LSVTSFKKIVYREYEPYFKKEKPQSTI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNLKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEVEESDADYDYQNRLAAALGIRSFRNSSLNQEEEE-FNLTALALENGT--EFVSS
NTDIIVGSNYSSPSNISK---------------------FTVNNLAEPQKAPSHQQATTA
GSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTGSPSRMKPWEDLPSQDTGSPSRMRPWEDPPSDLLLLKQNNPSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNWLISPQN--ASRAWG-EST--PLANKLGKQSGHPKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LKHSLMLHKSNETS-----LPTDLNQTLPSM-DFGWIASLPD
HNQNSSNDT-GQTSCPPGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------ISSSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQAVTSP-DL
SQVT---------------------LSPDLSQT-NPSPDLSHTTLSPELIQTNLSPALSQ
MPISPDL--SHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLS
LDLSQTNLSPELSHMTL-------------------SP-ELSQTNLSPALGQMPISPDL-
-S---------------------------------------HT-----------TLSLDF
SQTN---LSPEL---------SQTNIS--PALGQMPLSPD-PSH-TTLSLDHSQTNLSPE
LSQTNL------------------SPDLSEMPLFADLSQ--IPLTPD----------L--
D----------QMTLSPDLGETDLSPN--FGRMSLSPDLSQVTLSPDIS--DTTLLPDLS
QISPPPDL-DQI-------------FYPSESSQS----LLLQEFNESFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASAIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

ILAPCRRFWVLVVLGTS---WAGWGGPEAQAAQLRQFYVAAQVINWNY-RPPPPGP-SLN
TSATFFKKIVYREYEAYFKKEKLRSRI--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYPDRTFPVEQKDDAIAPGQEYTYEWRITEDSGPTHDDPPCLTHIYY
SYENLVQDFNSGLVGPLLICKKGTLTEDGTQKMFDKQYVLMFAVFDESKSWIQ-------
---------------SSSLMYTVNGYVNGTLPDVTACAHDHISWHLIGMSSGPELFSVHF
NGQVLEQNHHKVSAVVLVSAMPTTANMTVSPEGRWAISSL--IPKHF-QAG--MHAYLNI
ENCPKKTRSPKKLTRDQRRHIKRWEYFVAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
VENP-DAQEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSGNDFPNENNFEN
NFFSGH-SFMIRPVQPGETYTYKWTILESDEPTENDAQCLTRPYYSDVDATRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IQTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLALFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMSSSPRS
QKLRLRFRDVKCIRDD-YEGSYEI-MYGPPT----SI--------------PMDTRK-MH
DSLENKSGEDATEYDYQDSLASSLGIRSLRNSSLNQEEDE-FNLTALALENSP--DFIPP
SADTAVGSNSSSPSNISW---------------------LIDNDLSKPQKTLPHAQATTI
GSLLGHPTGLDKNLALNPSTT---EHSNPYSE--------------KDPLQSGVTGISFL
PL--GASGFRSQKDAKYKVLKAERDRAA-----------------KLRISRKEIPAHKTG
KHLRENNI-----------------STSSMGPWEDLSSNLLLLKQKNPSKILNGKWHLAS
EKGSYDIIQETD--EDM-TVNKLLNSPQN--GSRPLG-SST--PLTNKHGKQTGHPGFSG
VRHKPLQVRQDGKSHGLKKTSFYIKTRKKKKEGKLTPHVLMSP-----------------
-----------------------------------------------------------R
GFNPQRGEAYTTFSDRK-LDDSLLLLKSSEAS-----LLTDLNWTLPSM-NPGLITSLPD
HGQNPPNNNTGQTISPPDPYQTVHPE-----ERSH---IQDHDQKSSLSERR--------
--------ST-----PL-PPWD-LK-SSQKTNSPRLQS-T-HPSPQT-SAQRPS------
APDD--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-FSSELSQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDLNQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

TLSPDISQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1987)

AALSPD

PF06049 // ENSGT00910000143988_0_Domain_17 (1987, 2001)

DL------SSELSQTTLSLGLGQMTLSPDD-------------F----------
--------------------------SSELSQT-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DISQAALSPDD----------
------------

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

-LSSELSQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-QA---------------------ALSPD-
---D---FSSELGQT

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

ALSPDLSQAALS--PD---------D-----

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

-LSSELSQ

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
ISQTALSPDN---

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

-LSSELSQTTLSPDL--------------------SQT

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2313)

TLF-PE---
-----------------------------FSE

ENSGT00910000143988_0_Linker_48_54 (2313, 2314)

T

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

NLPSDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

A

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TFSSELS--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

M

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

TLSPDLR
QTLPPLDL-DQT-------------SYTSESNQS----

PF06049 // ENSGT00910000143988_0_Domain_58 (2379, 2387)

LPLPEFGQ

ENSGT00910000143988_0_Linker_58_60 (2387, 2388)

T

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FL-------HS--
-----DLGQIP-SPPPTPTLDDALIPTEFNPPVVV-GLPRD-DGDYVEIIPRQEF-HSSE
E---D-SV-EIDYVRYDDPYQTDIRTDINSCRNPDSIAAWYL-RSN--NGNRKIYYIAAE
EISWDYSKFAQS---KTDN-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------EEDTE--DAPKNTVYKKVVF-RKYLDSTFTKHDPR
GEYEEHLGMLGPIIRAEVDDVIQVHFKN-LASRPYSLHAHGLSYEKSSEGKTYDDDSPEW
FKEDNAIRPNDTYTYVWHATERSGPEDPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKESSMPMDMREFVLLFMVFDEKKSWYYEKKP--KRSWTLASSEVK------NSHE
FHAINGMIYGLPGLMMYEQEWVRLHLLNMGSSQDIHVVRFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQQAGMQTLFLIIDRGCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLS-YWEPKLARLNNSGSYNAWSMEKPSRESGSNSWIQVDMQREVVLTGIQTQGAK
HYLKPYYTTEFYVAYSSDHSSWQVFRGNSTRSPMYFAGNSDASTVKD-NQFDPPIVARYI
RVFPTTVHNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESRKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKTSWWG---HDW
EPAYARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYAI
HYSDQGVEWKPYRVKS-GVVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYLAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTDDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPGNMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISK---------------------LTVNNFAEPQKTPSQPQAITA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVSPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEILQDTD--EDT-AVNNRLISPQN--ASHAWG-EST--PLANKSGKQSGHPKFPR
VRHKSLQVRQDGGKSGLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYETFPIQDPDEMHSTSNPSH-------
-------RSSAPELSEM-LEYD-RI-HKSF--PTDISQ-M-SPSSER-EVWQTVTSP-DL
NQVT---------------------LSPQLSQT-NFSPDLSHTTLSPELSQTNLSPALGQ
MPMSPDL--SQTTLSPDLSPTTLS------------------------------------
------------------------------------------------------------
------------------------------------PD-LSPT-----------TLSPDL
SHTN---LSPDLSHTTLSPDLSQTNLS--PALGQMPMSPD-LSH-TTLSPDLSHTNLSPD
LSHTTLSPEL---------SQTNLPSALGQMSMSPDLSQ--TTLTTDLSHTTLS-PDL--
S----------QTNLSPELSHTNLSPA--LSQMPLSPDLSQVTVSPDIS--ETTLLPDLS
QISPPPDL-DQT-------------FYPSES-----------KFNETFP-------YP--
-----DLGQMP-SP-SPPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSTYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVEMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DPLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISK---------------------LTVNNFAEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKRKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPGKQSGHPRFPR
VRHKSLQVRQDGGKSGLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRTEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-RQTSSPPDLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPELREM-LEYD-RS-HKSF--PTDISQ-M-SPSSER-EVWQTVPSA-DL
SQVT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALGQ
MPM

PF06049 // ENSGT00910000143988_0_Domain_17 (1984, 1992)

SPDL--SHTTLSPDLSHT

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TLSPDLSH

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

T

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2017)

TLSPDL

ENSGT00910000143988_0_Linker_20_21 (2017, 2020)

SPT

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLSHTTL----------
------------------------------------------------------------
----SPDLSHT-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2119)

TLSPDL

ENSGT00910000143988_0_Linker_33_34 (2119, 2124)

SPTT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-H

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

T

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2141)

ILSPD-L

ENSGT00910000143988_0_Linker_32_36 (2141, 2155)

SPT-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2217)

TN

PF06049 // ENSGT00910000143988_0_Domain_43 (2217, 2224)

LSPD
LSH

ENSGT00910000143988_0_Linker_43_49 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_49 (2225, 2293)

TL-----------------------------------------------S-PDL--
S----------Q

ENSGT00910000143988_0_Linker_49_51 (2293, 2295)

TN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSHTNLSPA--LGQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQL----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVHR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MLLVCPRFFLLVVLSTR---WAGWGSHQAEAARLRQFYVAAQGILWNY-HPEPTDP-SLN
S-IPSFKKIVYREYEQYFKKEKPRS

PF07732 // ENSGT00910000143988_0_Domain_0 (86, 201)

SN--SGLLGPTLYAEVGDVIKVHFRNKADKPLSIH
PQGIKYSKFSEGASYADHTFPAERKDDAVAPGEDYTYEWIVSEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTINGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRYMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPANMDKIYR-------SQHLDNFSNQIGKHYKKVIYRQYEEETFTKR
TDNP-SIKQS

PF07732 // ENSGT00910000143988_0_Domain_3 (491, 567)

GILGPVIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGINS
SSTSGS-HTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDQRGVQRVADMEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRR
HEDTLTLIPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPKR
RNLRLRFRDVKCNRDYDNEDSYK--IYEPPA----PT--------------SMTTRR-IH
DSLENEFGIDNEDYDYQYLLASSLGIRSFKNSSLNPEENE-FNLTALALENSS--EFISP
STDRVVDSNS--SQILSK---------------------IINNNLKDFQRTLPGSGATVA
GTLLRNLIGLDENFVLNSSTE---HRSSSYHENDM-----------ENP-QSNITVVYLL
PL--GPKGSGNREQDKPKTIKTGRPHMM-----------------KHRFSWMKAPAGKTG
RYSNPKNS------------------YSRMKSEEDIPSELIPLKQKITSKFLNRRWRVAS
EEGSYEIIAANG--EDT-DVDKLTNSPQNQNITVPRG-EST--SHTNTTRKPSDLPTFSG
VGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSP-----------------
-----------------------------------------------------------R
GFDPLRGYNHPPFSDRRLLNHSLLLHKSNETA-----LSPDLNQTSPSM-STDR--SLPD
YNQYSKNDT-EQMSSSLDLYQSVPPK-----EHSPTFPAQDPDQTHSTTDPSY-------
-------RSSPSELSQG-LDYD-LS-HDFY--PDDIGL--------------TSFFP-DQ
SQKS---------------------SFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQ
LLLSPEDNQ--KTSSPDLGQVPLSPDDNQKTTSPDLGQVPLS------------------
-------------------------------------P-EDNQK-TSPDLGQVPLSPDDN
QKTSSPDVGQV-SLSPDDNQKT--SSPDLG-QVPLSLD-DNQKTSSPD--LGQVPLSPDD
NQKM---TSPDLGQVPLSSDN-QKTSS--PDLGQVPLFPE-DNQ-NY----------FLD
LIQVPLSSDQNQETSSTD--LLTLS---------PDFGQ--TVLSPDLDQLPLP-SDN--
S----------QVTVSPDLSLLTLSPD--FNEIILAPDLGQVTLSPDLI--QTNPALNHG
HKASSADP-DQA-------------SYPPDSGQA----SSLPELNQTLP-------HP--
-----DLTH-IPPPSPSPTLNNTSLSRKSNPLVVV-GLSRV-DGGDVEIVPSEEL-ERID
E---D-YA-EDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYL-RGH--GGHKKFYYIAAE
EISWNYAEFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------HEDTG--HTPKDTTYKKVVF-RKYLDSTFTSRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDESPEW
FQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHMERNLPMDMREFVLLFMVFDEKKSWYYEKS---KGSWRIESPEEK------NAHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGSSRDIHVVHFHGQTLLDNRTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLT-YWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAK
HYLKSCFTTEFQVAYSSDQTNWQIFRGKSWKSVMYFTGNSDGSTIKE-NRLDPPIVARYI
RIHPTKSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGLEDGRIQNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSI
QYSDQGVEWKPYRQKS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MSPGHPSLWVLVVLGIG---WLDLGQHVAEAA-VRHRYIAAQIINWTY-RPPTSNP-SLK
PSEPTFKKMVYREYEAGFTQEKPRSNI--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLFAEVGDTLKVHFKNMAKKTLTIH
PQGIAYNKLSEGACYTDQTSPAEKMDDAVLPGQEYTYTWMITEDSGPTDDDPLCLTHIYY
SYDNLVLDFNSGLIGPLLICKKGSLTVDGTQKMFDQQHVLMFAVFDESKSWQR-------
---------------SPSLMYTVNGYVNGTLPDVTVCAYDQISWHLIAMSSGPELFSIHY
DGQVLEHNSRKVSAIPLVGATSTTANMTVSHEGRWQISSL--IPKHF-QAG--MKAYLKI
EKCPKATRKIHKLTRDQRRYIKKWEYFIAAE-----------------------------
---EVIWDYAPQNQENTDKKDN--------VWYNNLANQIGTRYKKVVYKQYQDESFTKR
IENS-SPEENGILXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX----XXXXXXX
XXXXXN-NTLVKAVQPGETYTYKWNILESDEPTGNDAQCLTRPYYSIVDMPRDIASGLIG
LLLICKSRTLDNRGVQRTADSEQQAVFAVFDENKSWYLEDNINRFCENPSSVKRDDPKFY
ASNIKSNLVLLAIN-------------------------------------G--------
--------FLPES------IPTLG-FCHEDTVQWHFCSVGIQDEILTLHVAGHSFLYGKR
HEDVLTLFPMSGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSISSNQRN
QNLRLRFRDVKCIRDY-EDDSYEI-VFELP-----------K--------NKATTRS-MP
DSTEAG---GEDDSDYQDELALQFGIRSFRNSSGPHEGDELLNLTSLFMEEIS--EMIPL
NVNASLGTSQPSPKDP--------------------------GSIPKLQATLPYSATTT-
GPPLKH-------SIALHSVL-HSKNPRPHSEEPV----------------GGLMGTALY
SL--DAEEIQSQVDAK-----------------KKEPEAERNTSVQYSHTQVELQTGTVR
VNLTP-SA-----------DLQSRDTPNSRAGTQHLLEDLVVVNQKDPPKVLNEKWNVVS
EKGNYEIIKDTN--EDK-VEDKLFNSPQD--ATKSRK-EGI----------------PSA
NWHNPLKIGKSRENGRFRKSSVLIKTRKRKRVTKFAQNMLMSP-----------------
-----------------------------------------------------------R
GFKPLKGRYNVTLLRWG-SNHSLLPDESNEVS--------------PTS-DLDQNFPTVD
LDQTFPPTEFSKISPDLKFSETVSTL-----D----------------------------
-----------------------------------FES----TTHHP-DFYQTFSPP-DL
HQTS---------------------LPLDLHETFSPPD----------------------
-----------------LNKMPXXXXXXXXXXXX------------------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXX----------
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX---XXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X---------XXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXFNAAIIV-G-TKA-DGNYVEYIPGQDLKDNED
DDDD---YVEDTYVHYDDPYQTDRRTDTSSLRNPDNIAAWYL-RSH--KGNRKNYYIAAE
EVLWDYSKFSKXXXX---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXVLFKN-LASRPYSLHAHGLSYEKSSEGKSYEDDSPEW
YQDDNAIQPNGTYTYVWHATERSGPENPGSACRAWAYYS-AVNTEKDIHSGLIGPLLICR
KGTLHKESNRPIDMREFVLLFMIFDEKKSWYRDKKP--KRMWAGLSSEVK------NTHR
FHAINGHIYNLPGLRMYEKENVRWHLLNMGGSQDIHVIHFHGQTLLENGTQLH-RLGAYP
LLPGSFKTLEMKASRSGLWLLDTEVGENQIAGMQTPFLIIDKECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QL
SASEQLG-YWYPKLARLNNGGSYNAWSTKQRAQSLSSEPWIQVNFEREVILTGIQTQGAK
QYLTPYYTTQFAVAYSSDKRMWRYFKGS-----SYFEGNSDASTIKE-NLFDPPIVTKYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

FLGCEVQG--CSTPLGMESQKIGNN

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSVKKSWLG---GDW
SPFYARLNAQG-RVNAWQAKSNNNKQWLQIDLLKTKKITAIVTQGANSFSNEMYVMTYSI
FYSDHGTEWKPYKDKP-SMTEKIFVGNVSPQGQVKNFFNPPIFSRFIRVI-----PKSWN
QSITLRIELFGCDIY---------------------------------------------
-----

MFPGCPCLWVLLVVGTS---WAGWGSPGAEAARLRQFYVAAQSISWNY-HPEPTHT-SSN
SSATSFKKIVYREYEAYFQKEKPRSRT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYPDHTFPVERMDDAVAPGQEYTYEWSISEDSGPTHDDPPCLTHIYY
SYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQQVLMFAVFDESKSWNQ-------
---------------SSSLMYTVNGYVNGTIPDITVCAYDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSATSTTANMTASPQGKWIVSSL--IPKHF-QAG--MQAYIDI
KNCAKKTRNPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDXXXX-------XXXXXNFSNRIDNHYK-VVYKQY-DESFTKR
IENP-NIKEDGLLGPVIRAQVRDTLKIVK-NM--GRTYSIYPHXXXXXXXX----X-XXX
XXXXXXSNTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEGVIRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPDS------IPTLG-FCFDDTVQWHFCSVGTQNDILTIHFTGHSFIYGKR
LENSXXXXXXXXXXXXXX----------XXXXX---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------XXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXX-XXXXXX----XX--------------XXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX--XXXXX
XX-XXXXXXX-XXXXXXX---------------------XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXX-----------XXXXXXXXXXXXXX
XX--XXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXXXXXXXX
XXXXXXXX------XXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--XXX-XXXXXXXXXXXXXXXXXXX-XXX--XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------
-----------------------------------------------------------X
XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-----XXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXX-------
-------XXXXXXXXXX-XXXX-XX-XXXXX-XXXXXX-X-XXXXXX-XXXXXXXXX-XX
XXXX---------------------XXXXXXXX---------XXXXXXXXXXXXXXXXXX
XXXXXXX---------XXXXXXXXXXXXXXXXXXXX-----------XXX----------
-XXXXXXX------XXX---XXXXXXX-XX----XXXX-XXXXXXXXXXXXXXXXXXXXX
X-X------XX-XXXXXXXXXX--XXXXXX-XX---------------------XX--XX
XXXX---XXXXXXXXXXXXXXXXXXXX--XX--XXX--XX-----------------X-X
XXXXXXXXXXX---XXXX-XXXXXX---------XXXXX--XXXXXXXXXXXXX-XXX--
---------------XXXXX-XXXXXX--XXXXXXXXXXXXXXXXXXXX--XXXXXXXXX
XXXXXXXXXXXX-------------XXXXXXSQS----LPPLDFDQIFP-------YP--
-----DLGQMP-SSPPHSTLNSTFIPREFNPPVVV-GLSRD-DGDYIEIIPRQKE-ENSE
E---D-YV-EDYYVAYDDPYQTDLRININSSRNPDNIAAWYL-RSN--NGNRKNYYIAAE
ELSWDYSKFAHXXXXXXXX-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXXX-----XXXX-XXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGILHKESNMPVDMREFVLLFMVFDERKSWYYEKKP--TRSWRLASSEVK------NSHE
FHAINGMINNLPGLRMYEQEWVRLHLLNVGGSQDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMKTPFHIIDRECKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3159)

QI
KASESLD-YWEPKLARLNNGGSYNAWITEKPSKETAFKPWIQVDMQREVLFTGIQTQGAK
HYLKSYYTTEFCVAYSSDQTNWRIFKGNSTRNVMXXXX

ENSGT00910000143988_0_Linker_66_68 (3159, 3222)

XXXXXXXXXXXXXXXXXXX---
XXXXXXXXXXXXXXXXXXXXXXXXXXCSTPLGMESGKIENN

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFRKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMFVKSYTI
QYSDQGVEWKPYREKSSSMVDKIFEGNSNIKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRVELFGCDIY---------------------------------------------
-----

MSPSRARLWVLLALGAG---LAGWGVRAGPAGVLREFYVAAQSVTWTY-RPEPSDP-SLN
PFSPSFKKIVYREYEPHFKKEKPRPSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVHFKNKADKPVSIH
PQGIKYSKFSEGASYLDHTSPAERMDDAVAPGQDYTYEWVISEDSGPTQDDPTCLTHIYY
SYKNLTEDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWNP-------
---------------SPYLMYTVNGYVNKTMPAIIVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHQKVSTVTLVSATSTTANMTVSPEGKWTISSL--IPRQF-QAG--MQAHIDI
INCPKKTRTTKKLTLEQRRYIKRWEYFIAAE-----------------------------
---EIMWDYAPIIPATMDKIYK-------SLHLDNFSNQIGKHYKKVVYRQYKDENFTKR
MDNR-NINPHGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPQGVTFSP----YEDEVNS
SSTSGN-HTMIRAVQPGEIYTYKWNILESDEPTDNDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQLAVFAVFDENKSWYIEDNINKFCENPERVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------FVPES------IITLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRN
KNLRLRFRDVKCIRDD-DEDSYE--IYEPLA-----L-------------PPMDVRK-MQ
SPSENEHEETGPDDDYQDSLASSLGIRSFRNLTLNQNEDE-FNLTALALENSS--ELISP
STGVVTGSNS-S----SR---------------------TTVNNFTEPQKTLSHAEASIA
GHLLEHLSGLDKNPVVSSSTE---EYSNPYFEDQI-----------EDPLQSDVTEISLL
----DARGFRDGEHAKHKEFRSERNQLT-----------------KHRFSWMKLPAHKTE
RHSNQDNT------------------SSIMGTWEDLPSDLLLLKQKNPSKILDGQWHVVS
EKGSYEIIQDND--EDK-AVNELLNSPQN--VSRIQK-ESI--PPENKPGKQSDPPKYSA
VRHKSLQVRQDTENSELRKRPLFIRTRKKKKEPKLTHRIPLSP-----------------
-----------------------------------------------------------M
GIHPLKGLRYTTFSDRK-LNRSLLLHKSNETS-----LPIDLNQTHPSV-NLVQTGSLPD
HNLSPPNNT-GPTSYSPDLYQTVPPE-----EHDQTSLIQDRDQMHSTTDPSH-------
-------RSFPPEPSQM-LSAD-LS-HELY--PLDIGQ-L-SHARER-EDWQITMSS-GL
SQTS---------------------SSSSQSQMT----------LPSDLSQMAISPDIGQ
MPLSPNLSQ--KTPSPDLSQMPLSPELGET------------------------------
----------------------------------DLSS-ELRQMTSSSNFSQIPLSPEFG
ETS---------------------PSTDL-------------------------------
SQTT---PSPDLSQMPLSPELGEANLS--PNLSQMAPSPD-LSQ-MPLSPELDETDLS-E
LSQMTSSPDLS---------QMPLSPEFGEASLSPNLVQ--MTPSPDLSQMPLS-PE--L
G----------ETKLPRNLSQMTSSQD--LNQIPHSPGLSQVTLSPDIT--ETTLPPNSR
QKLHPSDL-DQI-------------SYPSESSQL----LPLSEFNLTSP-------YP--
-----DLGHMPPSPLPSPTLNDTFISNELNPPVVV-GLSGD-DGEYIEFIPQPVQ-ITEE
K---D-YA-EIDYVNYDDPYQTDRRTDINSSRNPDDIAAWYL-RSN--KGNRKYYYIAAE
EISWDYAEFAQS---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDSD--DIKKDTTYKKVVF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLAYEKSSEGKTYEDDSPEW
FQDDNAVQPNSSYTYVWHATDRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKQSNIPVDMREFVLLFMVFDEKKSWYYGKY---KRAWKLESSEVK------DSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGVIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLN-YWEPKLARLNNGGSYNAWSVEKSKLKIASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSDRTNWKIFKGNSTKNVMYFDGNSDASTIKE-NQFEPPIMARYI
RISPTRSYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
YYSNQGTEWKPYRQKS-FMVDKVFEGNGNVKGHVKNFFNPPIISRFIRII-----PKTWT
QNIALRLELYGCDIY---------------------------------------------
-----

------------------------------------------------------------
----------------------------------------------------STRPLSFR
STGVPPKQPVQGALYPDNTTGLQKKDDRINPGERYTYRWTVPKEQGPASGDNNCVTRIYH
SHINTVKDVASGLIGPLLTCKKGTLYKN-KEKYVDKEFVMLFFIMD

PF00394 // ENSGT00910000143988_0_Domain_2 (227, 358)

ENQSWYLDDNIKTY
CTEPNKVDKENADFQKSNKMYSMNGYMFGNLPGLSMCAEDKVKWYFFGIGGAYDLHTIFL
HGQTVLFRNHRTDTMSIFPATLVDVSMEAKSIGEWMISCQ--VHKHM-RGG--MQAF

ENSGT00910000143988_0_Linker_2_3 (358, 492)

FEV
KDCKKPSTDKV--T-----GKSVKHYYIAAE-----------------------------
---EIIWNYGPTGIDHFTGKNLTAPGSEPEAFFVRGPTRIGGSYKKLVYREYTDDTFTKQ
KCRRPEEEHLG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 604)

ILGPVIRAEVEDTIKVTLYNK-GTHPVSIQPHGVRFTK----SNEGSHY
HTLHGGTPPPSSNVTPGANFTYEWTVPKGVGPSSTDPNCLTWLYYSGINTPEEINAGLIG
PLLVCRRGSLRADGKQKGIDREFFMLLTILDENESLFLDDNIKLFTTSPDQVKKGDADFQ
HSNKMYS-----IN-------------------------------------G--------
--------FMYGN------QPGLE-MCLGDRVSWHVFSVGSEKDLHGVHFSGGTLMITGG
RIDTATVFPQTSDTLFMI----------PDSVGLFNVLCLVSEHYTGGMKEKYRVNQCKA
SETDKTHH----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----

MSLGCPSLWVLVVLGTG---LLGLDHHGVEAA-VRHRYIAAQIIDWNY-HPQTSDP-SLK
PSESTFKKMVYREYDANFIQEKPRSNS--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 199)

LLGPTLFGEVGDILKVHFKNMAKKPLTIH
PQGIEYNKLSEGAFYADQTSPVEKMDDAVFPGQKYTYTWQITEDSGPTDDDPPCLTYIYY
SYENLVLDFNSGLVGPLFVCKKGSLTEDGTQKMFDQQHVLMFAIFDESKSWQP-------
---------------SPSLMYTVNGYVNGTLPDVTVCAHDQISWHLIGMSSGPELFSVHF
NGQVLEHNYRKVSAIPIVGGTSITANMTVSQEGRLSCLSFSDTLKHS-QAG--MKAHLKI
EKCSKATRKVKKLTRDQRRYIKRWEYFIAAE-----------------------------
---EVIWDYAPEIQENKDNLIQ-----------DIPTFCSLKHLGKVVYKQYQDKSFTKR
LESN-DPQEIGILGPIIRVQVRDTLKIVFKNM-ASRPYSIYPHGVTLST----DEEKAAN
FSTSGN-KTLVRAVQPGEIYTYKWTILESDEPTGNDAQCLTRPYYSMVDIQRDIASGLIG
LLLICKSRTLNNRGVQRTADSEQQAVFAVFDENKSWYIEDNINKFCENPSSVKRDDPRFY
ESNIKSNLDFSSIN-------------------------------------G--------
--------FLPES------IRTLG-FCYEDTVQWHFCSVGTQDDILTLHLTGHSFLYGKR
HEDVLTLFPMSGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSISSNWGS
QNLRLRFRDVKCRRDY-EYGSYDI-LFDDDA----EKVVTEK--------NKITTRN-MP
DTGE-------DDSDYQEELAWLLGLRSFKNSSGPQEGDELLNLTALFLEEIS--DRIPP
NVNASLDAHQLSPKDT--------------------------GSIPKPQAILPFSEGTTS
GPHLKN-TTTGKHFIALHPVDSILKNPRSHSEELA-----------KEDMHSNAMETTLS
PF--GAEEFQSQEDAKNGTNQVNEETSKVTTSSANQPEAERNTSAQINHTQGELPIGRVR
ENLTSEQP-----------HLQRSGIHNSRAGIQDL-GDLVAVYQKNPPQALNGKWNLVS
EKGSYETIKDTN--EDK-IEDKQLKSPQV--ATASWG-ERI----------------PST
NRQKPLKIGKNTANGRFQKSSFLIKTRKRKRINKSVHNVPMSP-----------------
-----------------------------------------------------------R
GFRPLQGEYNSTLIHKG-SNHSLLPNESIKM------DPIDLEQIFSIL-DLDQNFSSVD
LDQTIPPPEFGKISSDPNFSETFSTL----------------------------------
----------------------------------DLVP----TSHPA-DFYQTLSTP-DF
DEAH---------------------SPPDPYETSSPPP----------------------
----------------LFLQTPSPPNFYETIPHS------------------DLNEASFP
PDLNESPSSPNFYDTI-----PP---P-DLYEV-SFPP-DLNE-SPSPA-----------
------NFQET-TPFPDL-YIPSL-PLDPN-ESPSPP-NFYETT-PPSDQL-------DL
N-ET---PF--------SSDLYE-KATTM-GFSEL-PSP--------------------L
V---------NDQIFSP-------SDLYDE-SFPSDF-SEMSSP-PYLDKE-LFLTE-LY
QTSS-LPFFDQ-TSTTPD----------PYE-IYSFPD-PNWIDSP---------PDFYQ
P-SFPSD-LNQTS-STLD-LNQT-NFLP-EAGQ-ISP---TPEFSENFP-------SNLS
QTPFSLVLESPESQLLPPRINDSLIPREMTPAIIV-GLTKD-NGDYIEYDPGQDVKKSED
EDDDDY------YVHYDDPYQTDRRTDTSSLRNPDNIAAWYL-RSH--KGNRKNYYIAAE
EVLWDYSQFSKSMRK---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------DDDVDNIRRNTVYKKVIF-RRYTDGTFSVLDPR
GENEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPIIMAEVDDVIQVRFKN-LASRPYSLHAHGLSYDKSSEGKSYEDDSPEW
YQDDNAIQPNGSYTYVWHATERSGPENPGSACRAWVYYS-AVSPEKDIHSGLIGPLLICR
KGTLHKESNRPVDMRDFALLFMIFDEKKSWYFDKKP--KRIWTALSSEVK------NTHM
FHAINGQIYNLPGLRMYEKENVRWHLLNMGGSRDIHVVHFHGQTLLQNGTQLH-RLGVFP
LIPGSFKTIEMKASRPGLWLLDTEVGENQKEGMQTPFLIIDKECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
SASEHLG-YWHPKLARLNNVGSYNAWSTEKRTNSLSSEPWIQVDFQREVVLTGIQTQGAK
QYLTSYYTTQFCIAYSSDRRMWRYFKGNSTSKHEYFRGNSDASSIKE-NLFEPPIVAKYI
RITPIHSYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVQG--CSTPLGMENQKIENN

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSMKKSWLG---DSW
EPFYARLNAQG-RVNAWQAKSNNNKQWLQIDLLKPKKITAIATQGAKSLTSEMYVMTYAI
FYSDHGTSWKPYKDKL-SMTEKIFVGNVNTKGQVKNFFNPPIFSRFIRII-----PKSWN
QSITLRLELFGCDIY---------------------------------------------
-----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ALAEDGTLKMFDNQHVLMFAVFDESKSWTP-------
---------------SPALMYTVNGYVNGTMPDITACAYDHLSWHLIGMSSEPELFSIHF
NGQVLEQNRHRISAVTLVSATSLTANMTTSLEGRWNIVSL--IPKHF-QGT-PQTAHIAV
KNCPKKTRKSKTLTREQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPTSMDKKYR-------SLHLDNFSNQIGKQYKKVVYRQYEDASFTKR
LENP-NAQEDGILGPVIRAQVRDTLKIVFKNM-ASRPYNIYPHGVTFSP----YEDEVNA
SSTSGQ-NTVTRPVQPGETFTYKWNILESDEPTENDAQCLTRPYHSNVDFTRDIASGLIG
ILLICKSRSLDKRGVQRTADIEQLAVFAVFDENKSWYIEDNINKFCENPDEVNRANPKFY
ESNIMSXXXXXXXX-------------------------------------X--------
--------XXXXX------XPTLG-FCFDDTVQWHFCSVGTQDDVLTIHFTGHSFIYGKR
HEDTLTLFPMKGESVTVT----------MDN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSHRRA
KNLRLRFRDVKCVHDD-DEDSYEI-IYELAP----TP-------------TAMSTRK-MR
DFPENPE---GNDDHYQDPLASELGIQSFRNVSLQPEEEE-FNLTALALEDYP--DSISL
WTQTSDASNASSLSDSSK---------------------FMTNHLTEPQESPAFPEGIAA
DPRAEG-VSLDK------THPSAKEQSSPYSEDPI-----------EDPSQSEVTDIRLL
PHPEGSRGFRRPGHMTPQSFKTGRKRGTS----------------RRGSAQMGVAGHHNG
RQSSQDGS-------------------SPVQPQKEVHSKPLVFKLKNPSEILNKTWRVAS
EEGSYEVLQNAE--EGT-PGHKL-RHPET--GSRAWE-EKI--HLTDQHREQRDHVELSG
MRHRPLRAGQDGRHGGLRRNSLFVRTRKKKREQKFPHHAPLSP-----------------
-----------------------------------------------------------R
GFRGSAGTADRTLIPSP------LAHTFNRTS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-PLTDLNQTLPVTLDLRITHPLLD
NGQQAPRDTSXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRLATFSPNVSGSSLFS----
----------------GIRKT

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

ILSPDFDETTLSQGLDET

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TFSPDLGE

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TFPPDLSE

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLP
SDLNE

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSSDFSE

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSSDLSE

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TLPSDLSET-----------

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

TFSSDLDE

ENSGT00910000143988_0_Linker_26_30 (2093, 2094)

T

PF06049 // ENSGT00910000143988_0_Domain_30 (2094, 2163)

TLS----
---------------------------------------------------------SDL
DEPT---FSSDFSETTLSPELTLEK-------------------------------FSSHFREVTLSPDLTRDTISSDLSEVTLSPDLSGRRLPS-ID---------------------------------EEILPQD-----------LDELIFPPVFDWNTPSSDFS--EAT---------HPPEISPLV-------------SYTPRSGV--SQSPPLPERGRMFP-------SP-------DRDQRPPPGSSDPG------LRDLNPSVIV-GLRKD-DGDYIEYIPRRKVVTSEEE------VVEMDYVTYDDPYQTDIRTDINSSRNPEHIAAFYLRSNN--SGNRKYYYIAAEEIIWDYAKFAHXXXXXXXX------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------XXXXX---XXXXXXXXXXXX--XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRMPMGLSTGIINDLEVTASQYQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXX-XXXXXXXXNNNYKQWLQIDLLKVKKITAIVTQGCSSLSSEMYVKSYSIQYSDQGVEWKPYRQKS-SIVDK----------------------------------

PF06049 // ENSGT00910000143988_0_Domain_34 (2094, 2163)

TLS-------------------------------------------------------------SDLDE

ENSGT00910000143988_0_Linker_34_37 (2163, 2167)

PT--

PF06049 // ENSGT00910000143988_0_Domain_37 (2167, 2175)

-FSSDFSE

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPELTLEK-------------------------------FSSH
FREV

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

TLSPDLTR

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

D

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TISSDLSE

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

V

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TLSPDLSGRRLPS-ID----------------------
-----------EEILPQD-----------LDELIFPPVFDWN

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TPSSDFS--EAT------
---HPPEISPLV-------------SYTPRSGV--SQSPPLPERGRM

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FP-------SP--
-----DRDQRPPPGSSDPG------LRDLNPSVIV-GLRKD-DGDYIEYIPRRKVVTSEE
E------VVEMDYVTYDDPYQTDIRTDINSSRNPEHIAAFYLRSNN--SGNRKYYYIAAE
EIIWDYAKFAHXXXXXXXX-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXXX---XXXXXXXXXXXX--XXXXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX------XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRMPMGLSTGIINDLEV
TASQYQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX
XXXXXX

PF00754 // ENSGT00910000143988_0_Domain_68 (3247, 3322)

XXXXX-XXXXXXXXNNNYKQWLQIDLLKVKKITAIVTQGCSSLSSEMYVKSYSI
QYSDQGVEWKPYRQKS-SIVDK--------------------------------------
------------------------------------------------------------
-----

MALGCPRLWVLVVLGASCAGWGS---WGAEAARLRQFYVAAQGISWNY-RPEPTTL-SSN
P---SFKKIVYREYEPYFQKEKPQSKT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDIVKVHFKNKADKPVSIH
PQGIKYSKFSEGASYSDHTFPVEKMDDAIPPGQEYTYEWKISEDSGPTHNDPPCLTHIYY
SYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQHVLMFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSATSTTANMTMSPQGKWIISSL--IPRHF-QAG--MQAYIDI
KNCAKKTRNPKKLTRDQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
LENP-NIKEDGILGPIIRAQVRDTLKIVFKNM-ASRAYSIYPHGVTFSP----YEDEVNS
SFTSDN-STMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDVTRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFVYGKR
HEDTLTLFPMCGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTINSNPRN
KNLRLRFRDVKCIRDD-YEDSYEI-IYDPSA----PT--------------VMTTRK-MR
DSSENRAEERDADYDYQNNLASWLGIRSFRNSSRNQEEDE-FNLTALALENNS--EFIPP
STDTAASSNSSSLSNISR---------------------LIVYNFAKPQKTLPHPAGTTA
DPPLGP-IGLDKNSALNRSTT---EHSSPYSEDSM-----------EDPLQSDITGVSLL
PL--DAEGFQSQEHAKHKGSKKEREHTA-----------------KHKFSQVGFSAHKTG
RHLSQGNS-----------------SPSRRGPWEDLPNELFLLKQKNPSKILNGKWHVVS
EKGSYEIVPDAD--EDM-AVDKVLDSPQN--ASRTWA-ENI--PLTDKHRKLSGHPKFSG
IRNKPLQVKQDGGNSGLKKIPFFIKTRKK-KEEKFAHHTALSP-----------------
-----------------------------------------------------------R
GFHPLRGKGNTTFSDRR-FDHSLLPHKSGETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-FPTDLNQTFSSV-NLSLLASLLD
HNHNPPNDT-SQTSSPLDRYQTIPPE-----EHYQTFPIQDSDQMHSTTDSSH-------
--------TSPPEPGQM-LDYD-LR-NKPF--PTDIGQ-M-FPSLEY-EAWQATISA-GL
SQPT--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LSPDLDH----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDLSQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

ALSPDLRE

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

NFSP-----------DLDHTTFSLDLDQ-

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

MFSPDLDQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLDQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

SFSPDFDQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TFS
PDLDQ

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TFSLDFDQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TFNPDIDQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TFSPDLDQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

T-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DLSQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

TLSPDRGQ

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

T

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

SFSPDFD
R

ENSGT00910000143988_0_Linker_29_31 (2102, 2103)

T

PF06049 // ENSGT00910000143988_0_Domain_31 (2103, 2111)

TFSPDLDQ

ENSGT00910000143988_0_Linker_31_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TFSPDLDQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LPPDLS-QT---------------------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TFSPDL
DQTT---FSLDFEQT

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TFSPDLNQ

ENSGT00910000143988_0_Linker_38_39 (2184, 2185)

T

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

TLS--PDLDQTTLSPDHLDQ-S

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TFSPDLDR

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

M

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
LDQ

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

TFSLDLEQ

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

T

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TFSPDFDQ

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

T

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TFSPDLDQTTFSLGFDQ--T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TFFLDLDQ

ENSGT00910000143988_0_Linker_50_48 (2271, 2272)

T

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2293)

AFS-PDL--
D----------Q

ENSGT00910000143988_0_Linker_48_51 (2293, 2294)

T

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2302)

TLSPDLGQ

ENSGT00910000143988_0_Linker_51_52 (2302, 2303)

I

PF06049 // ENSGT00910000143988_0_Domain_52 (2303, 2311)

TFSPDLDL

ENSGT00910000143988_0_Linker_52_54 (2311, 2314)

SQT

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

TLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

E

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSSDIS--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

T

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

TLSLDLD
Q

ENSGT00910000143988_0_Linker_56_57 (2342, 2343)

M

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

LPSPDL-SQT-------------SYTSESSQS----FLLPEFGQT

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FP-------YP--
-----DLGQVP-SLPPSPTLNNTFMPREFNPPVLV-GLSAN-DGDYIEIIPRQKE-ESSE
E---Y-TA-EIDYVAYDDPYQTDTRTDINSSRNPDNIAAWYL-RSN--NGNRKYYYIAAE
EVSWDYSKFAQS---EDV------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------D-DI-----PENTIYKKVVF-RKYLDSTFTKRDPL
GEYEEHLGILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATARSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGVLDK-TNTPMDMREFVLLFMVFDEKKSWYYEKKAQSPRSWRLASSDVK------KSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGSSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKSGWWLLDTEIGENQRAGMQTPFLIIDRECKMPMGLSTGVIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLG-YWEPKLARLNNGGSYNAWITEKPSAELDSKPWIQVDMQREVIFTGIQTQGAK
QYLKSYYTMEFSVAYSSDRTNWQIFKGNSTKNVMYFDGNSDASTIKE-NRFDPPIVARYI
RVSPTRSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENN

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRQKS-SMVDKIFEGNNNIKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MTLHCLQLFLLLLLGSW---WPDSEQNLAEAVKVREHYIAAQITSWTY-KPEPEEKSRLE
HSDPVFKKISYREYE

PF07732 // ENSGT00910000143988_0_Domain_0 (76, 202)

VDFKKEKPANTF--SGLLGPTLRAEVGDTLVVHLKNMADKPVSIH
PQGLVYSKNEEGSLYDDRTSPAEKQDDAVLPGQLYTYVWDISEEVGPREADLPCLTYAYY
SHENMAMDFNSGLIGALLICKKGSLNEDGSQKHFDREYVLMFGVFDENKSWQR-------
---------------SASVKYTINGYTDGTLPDLEACAYDNISWHLIGMSSKPEIFSIHI
NGQSMEQKHRRVSAVNLVGGASSTVNMTVTEEGRWLISSL--VQKHM-QAG--MHGYLTV
RDCGDKEVKKSRLSYRERLMVKTWDYFIAAE-----------------------------
---EVTWDYAPSIPDTLDRHYK-------SQHLDNFSNLIGKRYKKAIFRQYTDASFTKR
LEGP-RPKETG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 606)

ILGPIIRAQINDKVKIVFKNK-ASRPYSIYFHGVTLAK----NAEGADY
PLDPTSNGTQSRGVEPGKTHTYEWKITKTDQPTAQDAQCITRLYHSAVNTERDIASGLIG
PLLICKSEALTQKGVQKKADEEQQAVFAVFDENKSWYLEDNIKEYCSNPATVKRDEPKFY
NSNLMHT-----IN-------------------------------------G--------
--------YVSDS------SEILG-FCRDTVVQWHFSSVGTHDEIVSVRLAGHSFLYQGK
YEDTLSLFPMSGESVTVE----------MDNGGKWWNFTINAGVSHDNFKTRFFF-IKTL
KMYKNQESYAGYF-------KLI-------------------------------------
------------NKGRIVRDLFNKKPLFLRVFILSILSFHSSKRN-P-------------
--------------NSFILIILVKGHPLFIQ---KLLKYCVCQMFAN--------IASE-
YLD-------LNIE-----------SFNLFLSFSYPSVSW--VIFGFR------------
-------------------RRVPSLCMCSYLST---------------------------
-------------------TTYMIDN---------VHSHNTFISIAGTWLLASWGSPGRS
YGMRLRFRDAKCDYEEDET--FDVVDL---T-------PVKT--------ERKAVPTSAE
VDLQEN-EEDKEESDYQDYLASFYSIRSSRKAAGDEEK---QNLTALAWEQYE--DTDAM
SSE----------------VAAGSGLTAINSS--------GTTNNSKFLETHITPLPPVK
AE-------------------------------TFQSNHTSITAEEDLFLTSTRDGEADL
VF-----ENRSQ----------------------------------SNYE----------
I------------------------AHGNMSAGEYMLSN--------------GEHPVN-
--VAEELPADGK--------DSKSFPEKHQ-----------------EQSTGRGNYTTN-
-------------KKRKRRSSLAIKFYAVQKMNALLNHVR-NKNVSFADKTGA-------
------------------------------------------------------------
---PH-------------------------------SVHHTEDTSNEAVVGTGQLPIEYD
DDLEEEEKK----------------MENAMHTVNLTLDLDPIV-GDGS-NAS--------
------------------------------------------------------------
--------------------------------------------------------SLSE
PRISKDKPADVFPLEYMLD--------------------------------------NIS
PNS------------------SPALVKNLLETS--LPR------------T-G-------
--KYL----------------------------------------------------PKM
TSEEWNLVSAK-MNLGLEASLDKSA-----------------------------------
------DGKLNHHGRNG------TA-SINRED---------MKKYQGFSHLMGE------
-----------NQKGSHMH------QA-----QKGKEGN-NDTLTS-----SGTFVKIRR
KKKEGAKI-TY--------------LLSPRSRNPKKPSSSVAGLGHALFPGGTNHTAAAT
KAASEGPRVDVSRARHGESLNDSLTPRQFRPSITI-GLPRA-DGDYE-YVIGESYSDESS
G---G--EYEYHYVSFDDPYMTDPKVNISSQRNPDGIAEHYL-RS---RGNERRYYIAAK
EVCWNYAGYKKSTMR---N-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DKTCKDGSRRKVIF-QSYTDSTFSTLQDE
DEYTEHLGILGPVIRAEVDDVILVHFKN-LASRPYSLHAHGVLYEKSSEGSVYDDESTAW
FKEDDEVQPNNSYIYVWYASRRSGPVQSGAACRSWIYYS-DLNLEKDIQSGLIGPILICE
KGAFNKSDSSRTYTRDFFLLFMVFDEEKSWYFDKHS--GRPCNEKTQEMQ------HCHK
FYAINGITYNLQ

PF07731 // ENSGT00910000143988_0_Domain_65 (2953, 3040)

GLRMYEGETVRWHLLNMGGPKDIHVVHFHGQTFIEQGQP-EHQLGTYT
LLPGSFRTIEMKPQRPGWWLLDTEVGEYQQAGMQASYLV

ENSGT00910000143988_0_Linker_65_66 (3040, 3059)

IEKECRIPMGLASGVILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
DASHHID-YWEPKLARLNNYGTYNAWSATM-E---EELPWIQVDFRRQVLLAGIQTQGAK
QFFKSLYIQKYFLVYSKDKRTWNTFKGDSSPTGKIFEGNSNAYDIKE-NIIDPPIIARYI
RLYPTEVYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVDG--CSLPLGMESGEIKNT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSTMTSWFN----KW
DASLARLNQDG-KMNAWRAKLNNNQQWLQIDLLTVKKITAIATQGVTSMSAENFVKTYVL
LYSNEGSEWKTYTEGS-SSVPKVFLGNANSNGHVKNFFNPPILSRFIRIV-----PKTWY
RGIALRVELYGCDFGVGLAVKRTDESGSS-------------------------------
-----

MLLACPGFWVLVVLGTS---WAGWGNLGAEAARLRQFYVAAQSIRWNY-RPESTHL-SSK
PFETSFKKIVYREYEAYFQKEKPQSRT--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVHFKNKAHKPLSIH
PQGIKYTKFSEGASYSDHTLPVEKMDDAVAPGQEYTYEWSISEDSGPTHDDPPCLTHIYY
SYVNLVEDFNSGLIGPLLICKKGALTEDGIQKMFDKQHVLMFAVFDESKSWNQ-------
---------------TSSLMYTVNGYVNGTIPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNRRKISAITLVSATSTTANMTVSPEGRWTIASL--IPKHF-QAG--MQAFIDI
KNCAKKTRNPRKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPASMDKKYR-------SLHLDNFSNRIGKHYKKVVYKQYQDDSFTKR
LEDP-SSEGDGILGPIIRAQVRDTLKIVFKNM-ASRAYSIYPHGVTFSP----YDDEVNA
SSTSGS-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDVTRDLASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNDLLTIHFTGHSFIYGKR
HEDTLTLFPMQGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KKLRLRFRDAKCIRND-DDDSYEI-IYEPSG----ST--------------AMTTRK-MH
DSSEIK-DENDADSDYQEELASILGLRSFRNSSLNQEKDE-LNLTALALEKDS--EFIPP
SANRYLGSNSSSPRNVSR---------------------LIANNFAEPLKTLLHLEAPAA
GPALEH-AGLDKNSTLNPPMA---EHSSPYSEDHR-----------EDLPLSDVTGISLL
PF--GT-GFKNQKPAKHQRFQVGRGRAA-----------------KHRFSQTESPAHKTR
TRLSQDNS-----------------SASRMGLWEDIPSDLLLLQQKDPSKILNGEWHLVS
EKGSYEIIQDAN--ENK-TVNKLPNSPQN--ASRTWG-ENI--PFKNSHGKQSGHPTFLV
TRRKPLQDRQDRRNSRLKEGLPLIRTRRKKKEEKPAYHVPLSP-----------------
-----------------------------------------------------------R
SFHPLRGEVNASFSDRR-HNHSLLLHASNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LSIDLNQTFPSM-NLSLAASLPD
HDQTSPNDT-SQTSSPPDLNPTVSPE-----EHYQTFPIQDSDPTHSTT-----------
---AHSNRSPPTQPSQI-PNYD-LR-NKAI--PIDVSQ-I-FPSLEL-EVWQTATSL-DL
SQPS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-ISPDLGQ----------MAPTPDLGQE

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

SLSPDLGQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1983)

MG

PF06049 // ENSGT00910000143988_0_Domain_17 (1983, 2001)

LSP-----------DLSQ

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

E

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

SLSPDLGQTDLSPGLSQE

PF06049 // ENSGT00910000143988_0_Domain_22 (2020, 2046)

SL------------------S
PDLGQ

ENSGT00910000143988_0_Linker_22_24 (2046, 2048)

TG

PF06049 // ENSGT00910000143988_0_Domain_24 (2048, 2055)

LSPDLSQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

E

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

SLSPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2066)

TA

PF06049 // ENSGT00910000143988_0_Domain_27 (2066, 2073)

LSPDLSQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

E-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

SLSP-DLGQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2086)

TA

PF06049 // ENSGT00910000143988_0_Domain_26 (2086, 2093)

LSPDLSQESLSPDLP
D-----------------------------------------------------------
--------------------LSQESLS--PD-----------------LPDLSQE

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2223)

SLSPD
LG

ENSGT00910000143988_0_Linker_43_44 (2223, 2226)

RTA

PF06049 // ENSGT00910000143988_0_Domain_44 (2226, 2233)

LSPDLSQ

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

E

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2241)

SLSPDLGQ---------------------------------------
--------------------------------------------------------LDLK
QTSPPLDL-DQT-------------SHTSESSQS----LSLPEFGQTFL-------YA--
-----DIGQMP-SPPPDSTLNNTFIPEEFNPLVVV-GLSRD-DGDYIEIIPGQKE-ESSE
E---G-YG-EFEFVAYNDPYQTDLRTDISSSRNPDNIAAWYL-RSN--NGNRKNYYIAAE
EISWDYSKFAQS---EDT------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------D--DVPEDTVYKKVVF-RKYLDSTFTKLDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNSTYTYVWHATTRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKETNMPVDMREFVLLFMVFDEKKSWYYDKKP--TRSWRHASSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LMPGSFKTLEMKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
QASEFWG-YWEPKLARLNNGGSYNAWIAEKLSTEFNPQPWIQVDMQKEVLLTGIQTQGAK
HYLKPYYTTEFCVAYSSDQKNWRIFKGNSTKNVMYFGGNSDASTIKE-NQIDPPVVARYI
RISPTRSYNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---NYW
GPFLARLNAQG-RVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMDWKPYREKS-SMVDKIFEGNNNVRGHVKNFFSPPIISRFIRI-----IPKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLLVCPRLCFLVVLSTS---WAGWGSYRAEAARLRQFYVAAQGILWNY-HPETKDP-SLN
S-IPSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKADKPVSIH
PQGIKYSKFSEGASYPDHTFPAERMDDVVAPGEEYTYVWLITEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSP-------
---------------SPSLMYTVNGFVNRTMPDITVCAHDHVSWHLMGMSSGPELFSIHF
NGQVLEQNQHKVSTITLVSATSTTANMTVSPEGKWIVSSL--IPKHY-QAG--MQAYIDI
KNCLKKTRNPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPANMDKKYR-------SLHLDNFSNRIGKQYKKVIYRQYEEETFTKR
TENP-GFKQSG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 567)

ILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGS-HTMIRPVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDVTKDLASGLIG
LLLICKSRSLDQRGIQRTADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YMPES------ISTLG-FCFDDTVQWHFCSVGIYDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRH
KNLRLRFRDVKCIRNDDDEDSYE--IYEPLA----PT--------------SMTTRK-IH
ESSENEVGIDSEDYDYQSLLASSLGIRSFRNSSLTQEEDE-FNLTALALENSS--EFISP
RTDRVNDSKS-SPRNFSG---------------------IPANDLEESQRTLPGSGAAMT
GTLLKDLTSLDENSVLNPFTE---HHSSSYYENDM-----------NDS-QSDITVVHLL
PL--GAKGLMSQEQAKQKTAKRERLHLM-----------------KHRFPQMKSPARKTA
RHANPKNT------------------YPRTRSREDIPSDLFLLKRKNTSNFLDMEWYLAS
EKGSYEIIPANG--EDT-AVDKSPDSPQNQNISMTLG-NST--SPAKTTGKSGDFPVFPG
IRHKSPQVRQEEGNSDLKKRQLFIRTRKKKKNKKVASHSPLSP-----------------
-----------------------------------------------------------R
GFHPLR-DAKPTFLDQR-LNHSLLPHNPNETT-----LAIDLNQPSPST-NIDR--SLPD
YNQSTPHDP-GQMSTPLDLYQSVPPE-----GQSPTFPVQDPDQVHATTDPSH-------
-------RSPFPEPSQG-LDYD-LS-HESY--PEDIGQ--------------TAFFP-GQ
SQKS----------------------LSSEDGQTIPSSDLSLFGISPELDQIIISPDLGQ
VALSPDDNQ--MTSPEDLGQVALSPDDNQMTSPE--------------------------
------------------------------------------------DLGQVALSPDNN
QEASSQDLGQV-PLSPDDNQEA--SSPDLG-QVPL-------------------------
------------------------------------------------------------
------SPDDNQEASSPDLGQVALS---------PDDTQ--I-TSPDLSLLTLP-PEY--
D----------QTVLSPDLDQMTLSPD--FDEIILSQDLSQVTLSPDLI--QTSPPLNHR
QKTASSDP-GQA-------------SYPSDSGQF----SPLPEQNQTLP-------HP--
-----DLIP-IPSPLPSPTLNSTSMSKEFNPLVVV-GLSRV-DGDDIEIIPDEQL-ESID
D---D-YA-EDYYVSYNDPYKTDSRTNINSSRNPDTIAAWYL-RSH--RGNKQYYFIAAE
EISWDYAKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--GIPKDTTYKKVVF-RKYLDSTFTRRDLH
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVGDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAVQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHPESNLPMDMREFVLLFMVFDEKKSWYYEKS---KRSWRIESPEVK------NSHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLDNSTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEIGENQIAGMQTPFLIIDKECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASGHLS-YWEPKLARLNNGGSYNAWSIEKSTLDFAFQSWIQVDMQKEVVVTGIQTQGAK
HYLKSCFITEFHVAYSSDQTSWQIFRGNSTKNVMDFAGNSDASTIKE-NRLDPPIVARYI
RIHPIKSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGLEDGRIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DFW
DPFRARLNAQG-RVNAWQAKANNNKQWLQVDLLKVKKITAIVTQGCKSLSSEMYVKSYSI
QYSDEGVEWKPYRQKS-SMVDKIFEGNSNTKGHAKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MARGCPRLWVLVVLSAS---WAGWARPGADAMPNMPFKLVLY-----------FIS-SLN
PLATSFKKIVYREYEAYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKLSEGASYTDHTFPVEKMDDAIAPGQEYTYEWTISEDSGPTQDDPPCLTHIYY
SHENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQLVLLFAVFDESKSWSP-------
---------------SSSLMYTVNGYMNGTMPDIMVCAHDHISWHLIGMSSGPEMFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTMSPEGKWIVSSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPIIPTNMDKKYR-------SLHLDNFSNQIGKQYKKVIYRQYEDESFTKR
IDRP-SIKEDGILGPVIRAQVRDTLKIVFKNS-ASRPYSIYPHGVTFSP----YEDEVNS
SSISGS-NTMIRAVQPEETYTYKWNILEFDEPTENDAQCLTRPYYSDVDMMRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPDS------IHTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWLLTTMNSNTRS
KNLRLRFRDVKCIRNE-GEDSYE--MYAPPA-----F-------------SGMATRK-MH
DSSENEDTKDNSEYDYQDLLA---------------SEDE-FNLTALALENSS--EFIPP
STDTADRSNSSSPSNISR---------------------LIISNSTEPQKTLHYPGTTTA
GPQWGPLVDLDNNSVLNSSTA---EHFNPYSEDPV-----------DDPLQSDVMGISLL
PL--ALGRFTRQEQAKHKEPRKEKDQAE-----------------KHRFSWMESPAHEMG
SHLSQSSNS-----------------PPRMQPWEDLSGDLLLLKQKNPSKILNDKWHLVS
EKGSYEIIQDTD--KDK-AFNKLLTNPQN--ASSSWG-EST--PLTNKPGEQSGRPELSR
VRHTSLQVTQNGGNRGLKKSPFFIRTRKKKK-EK---SVPLSP-----------------
-----------------------------------------------------------R
SFNPLRSEASATFSDRR-LGHSLLFHKSNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LSIDLNQTLPTI-SLGLIASLPD
HNQDLPKNA-GQTNSSPGFYQTVSPE-----EHYQTFPIQDPDQMLSTTDPRS-------
-------RSSPPGLDQM-LTYD-LS-LKPF--SVDIGQ-M-SPSSEH-KVWQATVFP-DL
RQTT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPDLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1955)

M-

PF06049 // ENSGT00910000143988_0_Domain_13 (1955, 1963)

PLSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

SLSPDLSQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1974)

EN

PF06049 // ENSGT00910000143988_0_Domain_16 (1974, 1981)

LSPDFSQ

ENSGT00910000143988_0_Linker_16_27 (1981, 1982)

I

PF06049 // ENSGT00910000143988_0_Domain_27 (1982, 2183)

PLSPDL-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------HQMAPF--PDLGQMPLFPE-LSE-TT--------------------------------------------------------PSPDLGQIHFS-PDL--N----------QMTLSPDLGEANLSPD--FSQIPFSPDLSQVTLSPDIS--QVTLRPDLKQTSPPPDL-DQT-------------SYPFESKQS----LPLPESSETVP-------YP-------DLDQMP-SPPSSPTLNDTFLSEKFNPVVIV-GLSKD-GEDYIEFIPRPDD-HSSEE---D-EV-KTDYVSYDDPYKTDTRTDTNSSRNPDNIAAWYL-RSN--NGNRKKYYIAAEEISWDYSKFVQR---EID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEDTD--DIQKNTIYKKVVF-RKYLDSTFTKRDPQGEYEEHLGILGPIIRAEVDDVIQVHFKN-LASRPYSLHPHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLMICRKGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKKS--KKSWSLTSSEVK------NSHEFHAINGLIYNLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNQQH-QLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLVIDRECKMPMGLSTGIISDSQIKASEYLG-YWEPRLARLNNGGSYNAWSVDRLAVEFASKPWIQVDMQREVVLTGIQTQGAKHYLKSCYTTEFYVAYSSDQTNWQIFKGNSTRNVMYFDGNSDASTIKE-NQFDPPIVARYIRISPTRSYNRPTLRLELQGCELNG--CSTPLGMENGKIENKQIT

PF06049 // ENSGT00910000143988_0_Domain_28 (1982, 2183)

PLSPDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H

ENSGT00910000143988_0_Linker_28_39 (2183, 2189)

QMAPF-

PF06049 // ENSGT00910000143988_0_Domain_39 (2189, 2195)

-PDLGQMPLFPE-LSE-TT-------------
------------------------------------------

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

-PSPDLGQIHFS-PDL--
N----------QM

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2300)

TLSPDL

ENSGT00910000143988_0_Linker_51_52 (2300, 2304)

GEAN

PF06049 // ENSGT00910000143988_0_Domain_52 (2304, 2313)

LSPD--FSQ

ENSGT00910000143988_0_Linker_52_54 (2313, 2314)

I

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PFSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIS--QVTLRPDLK
QT

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------SYPFESKQS----LPLPESSETVP-------YP--
-----DLDQMP-SPPSSPTLNDTFLSEKFNPVVIV-GLSKD-GEDYIEFIPRPDD-HSSE
E---D-EV-KTDYVSYDDPYKTDTRTDTNSSRNPDNIAAWYL-RSN--NGNRKKYYIAAE
EISWDYSKFVQR---EID------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--DIQKNTIYKKVVF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVHFKN-LASRPYSLHPHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLMICR
KGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKKS--KKSWSLTSSEVK------NSHE
FHAINGLIYNLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLVIDRECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLG-YWEPRLARLNNGGSYNAWSVDRLAVEFASKPWIQVDMQREVVLTGIQTQGAK
HYLKSCYTTEFYVAYSSDQTNWQIFKGNSTRNVMYFDGNSDASTIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCELNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DFW
EPSYARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
YYSDQGVEWKPYRQKS-SMVDKIFEGNSNTRGHVKNFFNPPIMSRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPGCPRLWVLVVLGTS---WAGGGSQEADAAQLRQFYVAAQVISWNY-HPQPPDP-SLN
LFTTSFKKIVYREYEAYFKKE

PF07732 // ENSGT00910000143988_0_Domain_0 (82, 201)

KPRSSI-SAGLLGPTLYAEVGDTMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYADHTFPEERLDDAVAPGEEYTYEWIITEDSGPMDDDPPCLTHIYY
SYVNLVEDFNSGLIGPLLICKKGTLIEDGTQKMFDKQLVLMFAVFDESKSWNQ-------
---------------SSSLMYTVNGYVNGTLPDITVCAYDHISWHLIGMSSGPELFSIHF
NGQVLEQNNHKISAITLVSASSTTANMTVSPEGRWSISSL--ISKHF-QAG--MQAYIDI
KNCPKKTRNPKTLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYEDESFTKR
VDN---NQKDGILGPIIRAQVRDTLKIVFKNK-ASHAYSIYPHGVTFSP----HEDEVNS
SSTSDN-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIG
ILLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCESPDKVNRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNDMLIIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTIRSSPRS
QNLRLRFRDVKCIRDYDDEDSYQI-IYEHKT----SS--------------TMDTRK-MH
DSSEDKSEMDDTDSDYQDTLASLLGIRSFSNSSMNQEKDE-FNLTALALENNS--EFIHP
STDGAVGSNPSSPVNMSR---------------------HIGSDLFGPQKTLPHPGTTIA
GPFLGHSTGLGKNSSLNPSTT---EYSTSYSEDPI-----------EEPLQPDVTGISLL
HL--GAKGFKSKEHNNHKGSKAGRHQAA-----------------KHKFPQKEIPAHKTG
RHLSKDNI-----------------SSSRMRPWEDTPSDLLLLRQKNPFKILNGKWHLVS
EKGSYEIIQETN--EDM-TDNKLLNNSQN--ASRAWE-EIN--PLTNKHGEQSGHPKFSG
VKQKFPQVRKFGENGDLKT--LFIKTRKRKKEQKRTHHIPVSP-----------------
-----------------------------------------------------------G
GFHSLRGESSTTFSDRK-LDHSLLLQKSNETS-----LPTNLNQTVPSV-NLGQIDSLID
HNQNKN--DISQTSIPPDLYQAMPPK-----EHYQTFPIQDPGQMYSTTDPSH-------
-------RSSPPEHNQM-PDYD-LS-HQPF--PTDISQ-T-IPSLEL-EVRQP-------
---T---------------------IFPDLSQ----------MALSPDLSQTTLSPDLSQ
MTLSP-----------EPSQVALSPELSQITLYPHQSQT---------------------
------------------------------------------------------------
------------------------------------------------------------
-------LSS--------------------------------------------------
------------------------------------------------------------
----------------------------EFSQTNNSPDHRQMTLSPDLR--RATFPPDLR
QTLPPPNL-NQT-------------SYPSETSQS----LPLPELSHTFL-------SP--
-----DLGQMP-SSSLTPTLNDTFKPGHFNPQVVI-GLTGY-NGDDIEITPKEEV-QSKE
E---E-SV-EIDYVAYDNPYQTDTRTNIKYSRDPDHIAAWYL-RSN--SGNRKYYYIAAE
EISWDYSKFSKS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--NAPEGTVYKKVVF-RKYLDSTFTKHDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2842)

IVGPVIRAEVGDVIQVRFKN-LAPRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSAPEDPGSACRAWAYYS-AVNPEKDIHTGLIGPLLICR
KGTLNKESNMPVDMREFVLLFMIFDEKKSWYYKRKP--KKSWTRASSEVK------KSHE
FYAINGLIYSLPGLMMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGTWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKGCKMPMGLSTGVISDL

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASQHLA-NWEPRLARLNNGGSYNAWSVEKLSIESGFKPWIQVDFQREVIFTGIQTQGAK
QYLTSHYTTEFYVAYSSDQMNWQVFKGNSTKNLMYFEGNSDASTIKE-NQFNPPIMARYI
RIYPTKSYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESQKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EASNARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKRITAIVTQGCKSLSSEMYVKSFTI
YYSDQGVEWKPYRQKY-SMASKIFEGNSNTKGHVKNFFNPPIISRFIRII-----PKTWN
HSIALRLELFGCDIY---------------------------------------------
-----

MFPACPCLWVLVVLGSS---WAGWGSLGAEAARLRQFYVAAQSISWNY-RPESTYL-SLN
TSATSFKKTVYREYEAYFQKEKPRSTT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYPDHTFPVERMDDSVAPGQEYTYEWNISEDSGPTHDDPPCLTYIYY
SYENLVHDFNSGLIGPLLICKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------
---------------XXXXXXXXXXYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGHVLEQSHHKISAITLVSATSTTANMTMSLEGKWIISSL--IEHFX-XXX--XXXXXXX
XXXXXXXXXXXXXXX--XXXXXXXXXXXXXX-----------------------------
---XXXXXXXXXXXXXXXXKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDASFTKL
LENP-DNKQDGILGPIIRAQVRDTLKITFKNM-ASRSYSIYPHGVTFSP----YEDEVNS
SSTSGS-NTMIKAVQPGETYTYKWNILESDEPKENDAQCLTRPYYSNVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSMGTQNDILTIHFTGHSFIYGKK
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KKLWLRFRDVKCIRDY-NDDSYDI-ISSS----------------------TSITTK-MR
ESSEIKDKNNDADXXXXXXXXXXXGIRSFRNSSSKQEEDK-FNLTALALENNS--EFIPP
STNRTVGSNSSSPGNISR---------------------LIANNFAQPLKILPHPEATTA
GPPLGH-TSLDKNSVLNPPTA---EHSSPYSEDSI-----------EDPLYSDVTGISLL
PF--GTEEFRNQEHAKRKRFKAGRGRGA-----------------KHRFSQMEFPAHKTG
RHLSQGNS-----------------SSSRIGPWENLPSDLLLLQQKDPSKILNGEWHLVS
EKGSYDIIQDAD--EVK-VVNKLPNSPQN--DSRTWG-ENI--PFKDKHGKQSGHPTFFV
TRHKPLQGRLDGGNSRLKKGLFLIRTRRKKKEEKPAHHVPLSP-----------------
-----------------------------------------------------------R
SFHPLRVEANTSFSDGR-HNHSLLLHPSNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPADLNQTLPSM-NLSLMASLPD
GDQNPPNDT-SQT

PF06049 // ENSGT00910000143988_0_Domain_6 (1814, 1822)

SSPPDLYQTVSPE-----EHYQTFPIQDSDPTHSTTVPSH-------
-------R

PF06049 // ENSGT00910000143988_0_Domain_8 (1869, 1877)

SPPPEPSQI-PDYD-LR-NKAF--PTDVSQ-T-FPSLEL-EVWQTTTSL-DL
SQPS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LYPDLSR----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDLSQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

TLSPDLGQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

M

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

ALSP-----------HPGQ

ENSGT00910000143988_0_Linker_17_19 (2001, 2002)

E

PF06049 // ENSGT00910000143988_0_Domain_19 (2002, 2019)

TL---------SPDLSQ

ENSGT00910000143988_0_Linker_19_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLSQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TFSPDLGQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

E

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLSQ

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TFSPDLSR

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

E

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

M

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

ALSPDLSQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

T-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2085)

TLSP-DLSQ-

ENSGT00910000143988_0_Linker_28_26 (2085, 2086)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2086, 2093)

FSPDLSQ

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

T

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

TLSPDFS
Q

ENSGT00910000143988_0_Linker_29_31 (2102, 2103)

T

PF06049 // ENSGT00910000143988_0_Domain_31 (2103, 2111)

TLSPDLGQ

ENSGT00910000143988_0_Linker_31_33 (2111, 2113)

E-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TLSPDLSQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-QE---------------------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

ILSPDL
SQ

ENSGT00910000143988_0_Linker_36_37 (2163, 2167)

TT--

PF06049 // ENSGT00910000143988_0_Domain_37 (2167, 2175)

-LSPDLGQ

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

E

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQ

ENSGT00910000143988_0_Linker_38_39 (2184, 2185)

T

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

TLS--PDLSQEILSPD------

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

-LSPDLSQ

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
LGQ

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

M

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

ALSPDLSQ

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

T

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TLSPDLGQ

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

T

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TLSPDLGQ

ENSGT00910000143988_0_Linker_47_48 (2251, 2252)

T

PF06049 // ENSGT00910000143988_0_Domain_48 (2252, 2313)

TL---------------------------
------------------------PPN--LSQ

ENSGT00910000143988_0_Linker_48_54 (2313, 2314)

M

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLNQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

A

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIS--QTSLPLDLR
QT

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPLDL-NQ

ENSGT00910000143988_0_Linker_57_59 (2352, 2379)

T-------------SHTSESIQS----

PF06049 // ENSGT00910000143988_0_Domain_59 (2379, 2387)

LPLPELGQTFP-------YA--
-----DLGQMP-SPPPHSPLNNTFIPREFNPLVIV-GLSRD-DGDYIEIIPRQKE-ESSE
E---D-YG-EFDFVTYDDPYQTDLRTDINSSRNPDNIAAWYL-RSN--NGNRKNYYIAAE
EVSWDYSKFAQS---EDT------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------D--DVSKDTIYKKVVF-RKYLDSSFNKLDPR
GEYEEHLGILGPIIRAEVDDVIQXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXEKDIHSGLIGPLLICR
KGTLHKETNMPVDMREFVLLFMVFDEKKSWYYEKKP--TRSWSRTSSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRWHLLNVGGSQDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDRDCKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFWG-YWEPKLARLNNGGSYNAWIAEKLAVEFNPKPWIQVDMQREVLFTGIQTQGAK
HYLKSYYTTEFFVAYSSDRTNWRIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPVVARYI
RISPTNSYNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSIKNSWWG---DYW
EPFLARLNAQG-RVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
QYSDQGVEWKPYREKS-SLVDKIFEGNNNIKGHAKNFFNPPIISRFIRII-----PKTWN
QNIALRLELFGCDI----------------------------------------------
-----

MFPALPCPWVLVVLGTS---WAAWGNLGTEAARVRQFYVAAQSISWNY-HPEPTHP-SSS
PFATSFKKIVYREYEAYFQKEKPPSRM--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFRNKADKPLSIH
PQGIKYSKFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYY
SYENLIQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWNQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAYDHISWHLIGMSSGPELFSIHF
SGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWPISSL--IPKHF-QAG--MQAYIDI
KNCAKKTRKPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
LENP-NNKEDGILGPVIRAQVRDTLKIVFKNM-ASRSYSIYPHGVTFSP----YEDDVNS
SSTSDN-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIG
LLLICKSRSLDKRGIQRTADIEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGNQNNILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRN
KKLQLKFRDVKCIRDD-DEDSYEI-IYEPSS----ST--------------TLTTRK-MH
DSSENKEEENDDEYDYQDLLASVLGIRSFRNSSLYQEDDE-FNLTALALENNS--EFIPP
STDRAVDSNSSSPGNISR---------------------APANTFTEPQKILPHPEATKA
GSPRRH-TGLVKNLVLNRRRT---QHSDPYSEDPI-----------ENPLQSVITGISLL
PF--GTEGFRNREHPKHKRFKAGRDQAA-----------------KHRFSQMEFPAHKTG
RHISQDNS-----------------SSSSIGPLEDLSSDLLLLERKDPST-INGKWHLVS
EKGSYEIVQDAD--EDM-AVNKLPNNPQN--ASRSWG-ENI--PFTNKHGKQRGHPIFV-
TRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKPVHHVPLSP-----------------
-----------------------------------------------------------R
SFNPLRGEANTPFSDRR-QNHSLLLHESNETF-----PPTDLNQTFPSM-NLSLIASHPD
HNQNLPNDT-HQTSSPLDLYQTVTPD-----EPYQTAPIQDLDPTHSTAVPSHQ------
--------SSLPEPIQM-HDYD-LR-NKAS--PTDVSE-M-FFSLKL-KAGHR

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1922)

TTSP-DL
N

ENSGT00910000143988_0_Linker_10_12 (1922, 1945)

QPS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-FSPELSQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDPGHVTLSQDLSQ
T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

TLSP-----------DLSH

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TLSPDLGH

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

T

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLSH

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLSQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TLSPDLSH

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2045)

TLS
PDLG

ENSGT00910000143988_0_Linker_23_24 (2045, 2047)

HA

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDLSH

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2063)

TLSPDLG

ENSGT00910000143988_0_Linker_25_27 (2063, 2065)

HA

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TLSPDLSH

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

T-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DLGH

ENSGT00910000143988_0_Linker_28_26 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

TLSPDLGH

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

T

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

TLSPDFS
Q

ENSGT00910000143988_0_Linker_29_31 (2102, 2103)

T

PF06049 // ENSGT00910000143988_0_Domain_31 (2103, 2111)

TLSPDLGH

ENSGT00910000143988_0_Linker_31_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TLSSDLSH

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-HT---------------------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2167)

TT--

PF06049 // ENSGT00910000143988_0_Domain_37 (2167, 2175)

-LSPDLGH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDFSQ

ENSGT00910000143988_0_Linker_38_39 (2184, 2185)

T

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

TLS--PDLGHMT----------

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

-LSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
LGH

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

TLSPDFSH

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

T

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TLSPDLGH

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

M

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TLSPDLDQTTLSLDFGQ--T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TLSPDLSH

ENSGT00910000143988_0_Linker_50_48 (2271, 2272)

M

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2293)

TLS-SEL--
S----------H

ENSGT00910000143988_0_Linker_48_51 (2293, 2294)

E

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2302)

TVSPDLSH

ENSGT00910000143988_0_Linker_51_53 (2302, 2303)

V

PF06049 // ENSGT00910000143988_0_Domain_53 (2303, 2308)

TLSPDL--REIPFSPDLRQA

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIN--E

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

T

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

TLSPDLR
QTSPHLDP-DKT-------------SYISESSQS----VTLPEFGQT

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2409)

SP-------FP--
-----DLG

ENSGT00910000143988_0_Linker_60_61 (2409, 2769)

QRP-SPPSHSTLNNTFIPREFNPMVVV-GLSRD-DGDYVEIIPRQQE-ENSE
E---D-YV-KIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
ELSWDYSKFTQR---EDI------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------D--DVPEHTIYKKVVF-RKYLDSTFTKLDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKENNMPVDMREFVLLFMVFDEKKSWYYEKKF--TRSWRLTSSEVK------NSHK
FHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKTSKAGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFWG-HWQPKLARLNNGGSYNAWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAK
YYLKSYYTTEFNVAYSSDQRNWRIFKGNSTKNVMYFNGNSDASTITE-NQFDPPVVARYI
RISPTESYNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGNIKNE

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNNQWLQIDLLKIKKITAITTQGCKSLSSEMYVKRYTI
QYSDRGVEWKSYREKS-SMVDKIFEGNNNIKGHVKNFFNPPIISRFIRII-----PKMWN
QSIALRLELFG--------------------CDIY-------------------------
-----

MFPGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNS-SLN
LSVTSFKKIVYREYEPYFKKEKPQSTI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNLKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEE-FNLTALALENGT--EFVSS
NTDIIVGSNYSSPSNISK---------------------FTVNNLAEPQKAPSHQQATTA
GSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTGSPSGMKPWEDLPSQDTGSPSRMRPWEDPPSDLLLLKQNNPSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNWLISPQN--ASRAWG-EST--PLANKPGKQSGHPKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LKHSLMLHKSNETS-----LPTDLNQTLPSM-DFGWIASLPD
HNQNSSNDT-GQTSCPPGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------ISSSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTVTSP-DL
SQVT---------------------LSPDLSQT-NPSPDLSHTTLSPELIQTNLSPALSQ
MPISPDL--SHTTLSPDLSHATLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLS
LDLSQTNLSPELSHMTL-------------------SP-ELSQTNLSP------------
------------------------------------------------------------
------------------------------ALGQMPLSPD-PSH-TTLSLDHSQTNLSPE
LSQTNL------------------SPDLSEMPLFADLSQ--IPLTPD----------L--
D----------QMTLSPDLGETDLSPN--FGQMSLSPDLSQVTLSPDIS--DTTLLPDLS
QISPPPDL-DQI-------------FYPSESSQS----LLLQEFNESFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMK------NSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGSSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASAIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLPVCRRLCILVVLGTS---WAGWGSHPAEAARVRQFYVAAQGILWNY-HPEHTDP-SLN
S-KPSFKKIVYREYEPHFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTMKVHFKNKADKPISIH
PQGIKYSKFSEGASYPDHTFPAERMDDAVAPGGEYTYEWVISEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTVNGFVNRTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTITLVSATSTTANMTVSPEGRWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPASMDKKYR-------SLHLDNFSNQIGKQYKKVIYRQYEEETFTKR
TENS-NIKQSGILGPIIRAQVRDTLKIVFRNM-ASRPYSIYPHGVTFSP----YEDEGNS
SSTPGS-HTMIRPVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDLASGLIG
LLLICKSRSLDQRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTYDDVLTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNIG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRL
KNLRVRFRDVKCIRNDDDEDSYE--IYEPSA----PT--------------SMTTRK-IH
DSSEYDFGINNDDYDYQFSLATQLGIRSFRNASLNQEEDE-FNLTALALENSS--EFIFP
NTDRVNDSKS--SRNLSG---------------------ITGNNLKESQRTPPGSGSTVT
GTLLKDLAGLDENSVLNPATE---HHSSSYYESDV-----------GDS-QSDITVIHLL
PL--GTKGSGSQEHAKHKKAKSERPNLM-----------------KHRFPHMKVPARKTG
RHSNPKNT------------------YSRVKSREEIPIELFLLKQKNTSKFLDREWYLAS
EKGSYEIIPAND--EDT-AVEKLPNSPQNQNISKSWG-DST--SPTKTAGKPSDIPVFSR
VRNKFPQVREEERNSSLMK----IRTRKKKKNKRLSLHSPLSP-----------------
-----------------------------------------------------------R
GFHPLKGDAQLTFLDQR-LNHSLLPHKPNESA-----PAIDLNQTSSST-SIDR--SLPD
HNQTLPHDT-GQKSSAFNLYQSVPPE-----EHSPTFPVQDPDQTHSATDLSH-------
-------RSSLPQPSQE-LDYD-LS-HESY--PEDISQ--------------ASFFP-DQ
SQKS----------------------LSSEDGQTSPSSDLSLFTVSPELDQTTISPDLGQ
VPLSPGDNQ--MTSPQDLGQVPLSPEDNQM------------------------------
------------------------------------------------------------
--TSPQDLGQV-SLSPGDNQMI--SSQDLG-QVPL-------------------------
------------------------------------------------------------
------SSNNTQKSSPQDLSLLTLP---------PEFDE--VALPQDLDELPLS-SD---
---------------SPDLSPLTLSPD--FDEIIISSDLGQVTLSPDLI--QTSPTLNHR
HKTASSDP-GQA-------------SHPSDSGQS----SPLPELNQTLP-------DL--
-----SHVPSEPSPLPSPTLNNTSVSEEFNPLVVV-GLSRV-DGDDIEITPNEEL-ESIA
D---DDYAEDEDYVTYSDPYKTDTRTNINSSRNPDNIAAWYL-RGH--GGNKQYYFIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--ATPKDTTYKKVVF-RKYLDSTFTRRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAVQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHPKSKLPMDMREFVLLFMAFDEKKSWYYEKF---KRSWRIESPEVK------NSHK
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSQDIHVVHFHGQTLLDNSTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQIAGMQTPFLIIDKGCKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASGHLN-YWEPKLARLNNGGSYNAWSIEKSALDFAFQSWIQVDMQKEVVVTGIQTQGAK
HYLKSCFITEFNVAYSSDQTNWQIFRGNSTKNTMDFAGNSDASTIKE-NQFDPPIVARYI
RIHPIKSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSMPLGLEDGRIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
DPSRARLNAQG-RVNAWQAKANNNKQWLQVDLLRIKKITAIVTQGCKSLSSEMFVKSYSI
QYSDQGVEWKPYRQKS-SMVDKVFEGNSNTKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLLVCPRFFLLVVLGTR---WAGWGSHQAEAARLRQFYVAAQGILWNY-HPEPTDP-SLN
S-IPSFKKIVYREYEQYFKKEKPRSNN-

PF07732 // ENSGT00910000143988_0_Domain_0 (89, 201)

-SGLLGPTLYAEVGDIIKVHFRNKADKPLSIH
PQGIKYSKFSEGASYPDHTFPAEKKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTINGFVNRTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRYMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPATMDKIYR-------SQHLDNFSNQIGKHYKKVIYRQYEEETFTKR
SDNL--SKQS

PF07732 // ENSGT00910000143988_0_Domain_3 (491, 567)

GILGPVIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGS-HTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDQRGVQRVADIEQQVVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPKR
RNLRLRFRDVKCNRDYDNDDSYE--IYEPPT----PT--------------SMTTRR-IH
DSLENEFGIDNEDYDYQYLLASSLGIRSFKNSSLNPEENE-FNLTALALENSS--EFISP
STDRIFDSNS--SRSLSK---------------------IINNNLKDFQRTLPGLGATVA
GTLLRNLIGLDENFILNSSTE---HRSSSYHENDM-----------KNP-QSNITVVYLL
PL--GPKGSGNREQDKPKTIKTGRPHMM-----------------KHRFSWMKAPAGKTG
RHSNPKNT------------------YSGMKSEEDIPSELIPLKQKISSKFLNRRWRVAS
EKGSYEIIAPNG--EDT-DVNKLTNSPQNQNITVPWG-EST--SHTNTTRKPSDLPTFSK
VRHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSP-----------------
-----------------------------------------------------------R
GFDPLRGDNHHPFSDRRLLNHSLLLHKFNETA-----LSPDLNQTSPSM-STDR--SLPD
YNQYSSNDT-EQMSSSLDLYQSVPPE-----EHSPTFPAQDPDQTHSTTDPSY-------
-------RSSPPELSQG-LDYD-LS-HDFY--PDDIGQ--------------TSFFP-DQ
SQKS---------------------SFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQ
LLLSPDDNQ--KTSSPDLGQVPLSPDDNQK-TSPELAQVPLS------------------
-------------------------------------P-DDNQKMTSPDLGQVPLSPDDN
QKTSSPDLGQV-PLSPEDNQKT---SPDLG-QMPLSPD-DNQKTSSPDLDLGQMPLSPDD
NQKT---SSPDLGQMPLSPDN-QKTSS--PNLGQVPLFPE-DNQ-NY----------FLD
LSQVPLSSDQNQETSSTD--LLTLS---------PDFGQ--TVLSPDLDQLPLS-SDN--
S----------QVTLSPDLSLLTLSPD--FNEIILSPDLGQVTLSPDLI--QTNPALNHG
HKASSADP-DQA-------------SYPPDSGQA----SSLPELNQTLP-------HP--
-----DLTH-IPPPLPSPTLTNTSLSRKFNPLVVV-GLSRV-DGEDVEMVPSEEL-ERID
E---D-YA-EDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYL-RGH--GGNKKFYYIAAE
EISWDYAEFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------HEDTG--HTPKDTTYKKVVF-RKYLDSTFTSRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDESPEW
FQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPILICR
KGTLHRESNLPMDMREFVLLFMVFDEKKSWYYEKS---KGSWRIESPEEK------NSHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGSSRDIHVVHFHGQTLLDNRTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLT-YWEPRLARLNNAGSYNAWSIEKSALDFPIKPWIQVDMQREVVVTGIQTQGAK
HYLKSCFTTEFQVAYSSDQTNWQIFRGKSGKSVMYFTGNSDGSTIKE-NRLDPPIVARYI
RIHPTKSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGLEDGRIQNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNKQWLQVDLLKIKKVTAIITQGCKSLSSEMYVKSYSI
QYSDQGVAWKPYRQKS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MSAGRAHLWVLLALGAS---LAGWGVQAGPAGVLRQFYVAAQSVTWTY-RPEPSDP-SLN
PLTPSFKKIVYREYEPYFKKEKPRSNI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDTMKVHFKNTADKPVSIH
PQGIRYSKFSEGASYFDHTSAVEKMDDAVAPGQEYTYEWVISEDSGPTKDDAPCLTHIYY
SYQNLTEDFNSGLVGPLLICKKGTLTEDGTQKMFDRQHVLLFAVFDESKSWSP-------
---------------SPSVMYTVNGYVNKSMPAITVCAHDQISWHLIGMSSGPELFSIHF
NGQVLEQNHQKVSTVTLVSATSTTANMTVSPKGKWTISSL--IPRQF-QAG--MQAHINI
INCPKKTRTTKKLTLEQSRYIKRWEYFIAAE-----------------------------
---EIMWDYAPIIPASMDKVYK-------SLHLDNFSNQIGKHYKKVVYRQFEDESFTKR
IDNR--IHHNGILGPIIRAQVRDTLKIVFKNT-ASRPYSIYPQGVTFSP----YEDEVNS
SSTSGN-HSMIRAVQPGETYTYKWNILESDEPTDSDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPETVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------FVPES------INTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMSSSPSS
RNLRLRFRDVKCIRED-DEDSYE--IYEPHK-----S-------------TPIDVRK-IH
PPSENELEETDPDTDYQENLASALGIRSFRNLSLDQNEDE-FNLTALALENSS--ELISP
STDVAPDSNSSL----SR---------------------TIVNSFKESQKTLSNAETTIA
GHLLEHLSGTDKNPVVNSSIE---DYSSSYSEYEI-----------EDPLLSDVRETSLL
----GAKGFRDGEHAKHTEFRTKRKQLT-----------------KNRFPWMKLPAYKNE
KHSNQDNT------------------SARMGTWEDLPSVLLLLKQKNPSHVLDGQWHVVS
EKGSYEIIQDND--GDM-AVNEFLTSPQN--VSSTWK-ESM--SPENKPGKQSHHPKYSG
FRYKSLQVGQDGKNRELKERPLLIRTRKKKRAPKLTYHIPPSP-----------------
-----------------------------------------------------------V
GIHSLKGAHYTTFSDTK-LKQSLLLYSSNKTS-----PPTDLNQTLPSI-N-VQIGSLPD
HTLSPPNDT-GQTSFPPDLYQIVPPE-----EHNQTSLIQDPDQMHSITNTSH-------
-------ISSPPEPSQM-LSYD-LS-QELY--PVDISQ-L-SHAQEH-EAWPLPMSS-GL
SEPS---------------------SPSSQGQMT----------FSSELSQMPLSPELGE
AKLSPNFSQ--MIPSPDLIQMPLSSELGGT------------------------------
----------------------------------GLSP-DLSQKNFSPELSQMSLSTELD
EAS---------------------LSPNLN-QMSLPTE-LGE-----------TGLSPDL
SQKN---FSPDLSQIPLSPELDEANLS--PN----------LNH-MSLSPELGETNLSSE
LSQMTSSPDLN---------QMSTPQELNETSLAPSFSQ--ISPSPDLSQMPLS-PELEL
G----------ETKLPHNLSQTTSSQD--LNQITLSLGLSKGTLSSDIT--ETTLPPNFR
QASHPSDL-DQI-------------SHPSESSLL----LPLSEFNQTSP-------YP--
-----DLDHMPPSPLPSPTFNDTLILNEFNPPVVV-GFSGD-DGDYIEIIPRKEV-KITE
E---D-YA-EIDYVNYDNPYQTDSRTDINSSRNPDDIAAWYL-RSN--KGNRKYYYIAAE
EISWDYAEFAQS---AMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDSD--DIKKDTTYKKVVF-RKYLDSTFTKHDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

LLGPLIRAEVDDVIQVHFKN-LASRPYSLHAHGLAYEKSSEGKTYEDDSPEW
FKNDNAVQPNSSYTYVWHATDRSGPESHGSACRAWAYYS-AVNPERDIHSGLIGPLLICR
KGTLHKQSNMPVDMREFVLLFMVFDEKKSWYYGKY---KRTWKVESSEVK------DSHK
FHAINGMIYNLPGLRMYEQEWVRMHLLNMGGSRDIHVVHFHGQTLLENGAQQH-QLGVFP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLH-NWEPKLARLNNGGSYNAWSIEKSRLKIASKPWIQVDMQKEVVLTGIQTQGAK
HYLKSCYTTEFYVAYSSDSTSWQIFKGNSTKNVMYFDGNTDATTIKD-NQFDPPIVARYI
RVSPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEANG--CSTPLGMEKGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
QYSDQGLEWKPYRQKS-SMMDKVFEGNTNVKGQVKNFFNPPIISRFIRII-----PKTWS
QSIALRLELYGCDIY---------------------------------------------
-----

MSPGRPSLWVLVVLGIG---WLGLEQHVAEAA-VRHRYVAAQIINWTY-RPQTNDP-SLN
PSEPTFKKMVYREYEAGFTKEKPTSDI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLFAEVGDTLKVHFKNMAKKPLTIH
PQGIEYNKLSEGASYADQTSPVEKMDDAVLPNREYTYTWFITEDSGPTDDDPPCLTYFYY
SYDNLVMDFNSGLIGPLLICKKGSLTENGIQKMYDRQHVLMFAVFDESKSWQQ-------
---------------SPSLMYTVNGYVNGTLPDITVCAYDQISWHLIGMSSGPELFSIHY
NGQVLEHNSHKVSAIPLIGASSTTANMTVSHEGRWKISSL--IPKHI-QAG--MKAYLKI
KKCPKSTRKVNKLTRDQRRYIKKWEYFIAAE-----------------------------
---EVIWDYAPENQENMNKRHS--------FWHKNNPNQIGTRYKKVVYKQYQDETFTKR
KENNKEPEESSILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTLST----DDETAMN
VSTSGN-NTLVKAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSTVDIPRDIASGLIG
LLLICKSRTLDNRGVQRTADSEQQAVFAVFDENKSWYIEDNINKFCENPSSVKRDDPKFY
ESNIKS-----TIN-------------------------------------G--------
--------LLPES------IPTLG-FCYEDTVQWHFCSVGIQDEILTLHLTGHSFLYGKR
HEDVLTLFPMSGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWELTSISSNHRS
RNLKLRFRDVKCIRNY-DDDSYEI-LFDDNL----EKVVTEK--------NKVNTRN-MP
DSEEEE-WIPDDDSDYQDQLALQFGIRSFKNSSGPHEGDELLNLTSLFMEEIS--EMTPL
NVTTSLETSQISPKDP--------------------------GSSSKLQATLPYSVITTT
RSPLKNITTTGTRSITSYTIDSSLKNSKSHSKELV-----------DKNTNSATVGTALS
PL--GAGIFQSQEDVKKAGHQANKETSTFITTSANQSEAERKTSVQSNHTRIELPTEK--
------LP-----------DLHRSDIPNSRAGTQDLLDDLVVVNQKDAPKVLNGKWNLVS
EKGSYEIIKDTN--EDE-VEDKLLNNPQD--GATSRR-EGI----------------PSA
NWHKPLKIGKNRENGRFRKSSVLIKTRKRKRVK-LADNLLMSP-----------------
-----------------------------------------------------------R
GFSPLKGRYSATLPHRG-SNHSLLSNDSNEIP-----SPKDLEQASPTL-YLDQNFSAVE
LDQKFPPAEFSKLSSDPKLVSTTHPP-----DVYQTSSLPDHHETPSPLAP---------
--------------------Y------ETFSHP-DLNE----TPFPP-SFYETTPPP-DL
YETT---------------------FPPSLYETT-PPP----------------------
----------------DLYEIPFPPSYYESTPPT------------------DFYEASFS
PDLNETPFPPSFYETT-----PP---P-DLYET-TFPP-SLYE-TTPPP-----------
------DLYET-PFPPSH-YETTP-SSDLN-KTPFPP-SYYEST-PPTDFYE-ASFSPDL
K-ET---PF--------PPYLYE-TTPPP-DLYET-PFPPYLYET-TPPPDLYK-TPFPP
S---------FYESTPP-------SDFYEA-SFPPHF-YDTTPP-PDFYEA-SFPPD-FY
DTTP-PPDFYE-ASFPPDFYD-TTPPPDFYE-ASFSPD-LYETTPP---------SDNYE
A-PSPPD-LNWNS-STLD-LNQT-HFLP-EVGQ-IFP---SPEFSENLP-------PDLS
HTPSSPVLESI-SQSLPSQINVTLTPRQVNPAIIV-GLTKA-DGGYVEYIPGQAVKDSDD
DDDDDDYDFEATFVPYDDPYKTDRRTDTSSLRNPDNIAAWYL-RSH--KGNRKNYYIAAE
EVLWDYSKFSKSMKK---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ADDAEDIIENTVYKKVIF-RSYLDNTFSMLDPR
GENDDHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLAYEKSSEGKSYEDDSPEW
YQDDNAIQPNGSYTYVWHATERSGPENPGPACRVWAYYS-AVNPEKDIHSGLIGPLVICR
KGTLHKESNRPIDMREFALLFMVFDEKKSWYFDKKP--KRK---ITSEVK------NAHR
FHAINGHIYNLPGLRMYEKERVRWHLLNMGGSQDIHVVHFHGQTLLENGTQKH-RLGSCP
LLPGSFKTLEMKASRPGIWLLDTEVGENQIAGMQTPFLIIDKECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
SASSFLG-YWYPKLARLNNSGSYNAWSVEKQLYSFSSEPWIQVDFEKEVVLSGIQTQGAK
QYLTSYYTTQFRVAYSSDKRMWRYFKGNSTSKQEYFEGNSDATSIKE-NPFDPPIVAKYI
RISPTHSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCQVQG--CSTPLGMESGKIQNN

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSTRKSWLG---GYW
SPFYARLNAQG-RVNAWQAKSNNNKQWLQIDLLKTKKITAITTQGAKSFSNEMYVMTYAI
FYSDRGTDWKPYKDKS-SMREKIFMGNVNHKGQVKNFFNPPIFSRFIRLI-----PKSWN
QSITLRLELFGCDLY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPQSTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDGGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGEIYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISR---------------------LTVNNFAEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKLGKQSGHPRFPR
VRHKSLQVRQDGGKSELKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRTEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSER-EVWQTVT

PF06049 // ENSGT00910000143988_0_Domain_10 (1916, 1923)

SP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALGQ
MPMSPDL--SHT

PF06049 // ENSGT00910000143988_0_Domain_17 (1993, 2001)

TLSPDLSH

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2008)

TLSPDL

ENSGT00910000143988_0_Linker_18_20 (2008, 2011)

SPT

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2017)

TLSPDLNL----------------------
------------SHTTVSPDLSPT

PF06049 // ENSGT00910000143988_0_Domain_26 (2065, 2111)

TL----------------------------------
----SPDLSHT-TLSPDLSPTT--LSPELS-HTILSPD-LSPT-----------TLSPDLSHTN---LSPDLSHTTLSPDLSQTNLS--PALGQMPMSPD-LSH-TTLSPDLSHTNLSPDLSHTTLSPDL----------------TLGQMPMSPDLSQ--TTLSPDLSHTTLS-PDL--S----------QTNLSPELT---------LGQMPLSPDLSQVTVSPDIS--ETTLLPDLSQISPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP-------DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSED---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAEEISWDYSEFVQR---ETD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEDSD--DVPEDTVYKKVVF-RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHEFHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWALLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDSQIKASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIGNKQITASSFKKSWWG---DYWEPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTIHYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWNQSIALRLELFGCDVY----

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2111)

TL--------------------------------------SPDLSH

ENSGT00910000143988_0_Linker_27_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2119)

TLSPDL

ENSGT00910000143988_0_Linker_33_34 (2119, 2124)

SPTT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPELS-H

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

T

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2141)

ILSPD-L

ENSGT00910000143988_0_Linker_32_36 (2141, 2155)

SPT-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2217)

TN

PF06049 // ENSGT00910000143988_0_Domain_43 (2217, 2224)

LSPD
LSH

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2230)

TLSPDL----------------TLGQMPM

PF06049 // ENSGT00910000143988_0_Domain_49 (2254, 2262)

SPDLSQ--

ENSGT00910000143988_0_Linker_49_50 (2262, 2263)

T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TLSPDLSHTTLS-PDL--
S----------QTNLSPELT---------LGQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DVPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFLACPGFWVLVVLGSS---WAGWGNLGAEAAKLRQFYVAAQSIRWNY-RPESTHL-SSK
PFETSFKKIVYREYEAYFQKEKPQSRT--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKAHKPLSIH
AQGIKYSKFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWIISEDSGPTHDDPPCLTHIYY
SYVNLVEDFNSGLIGPLLICKKGTLTEDGTQKMFEKQHVLMFAVFDESKSWNQ-------
---------------TSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFTIHF
NGQVLEQNHHKISAITLVSATSTTANMTVSPEGRWTIASL--IPRHF-QAG--MQAYIDI
KNCAKKTRNPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNRIGKHYKKVVYKQYQDDSFTKR
LEDP-SSEGDGILGPIIRAQVRDTLKIVFKNM-ASRSYSIYPHGVTFSP----YDNEVNS
SSTSGS-NTMIRAVRPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDLASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFY
ESNIMSNFTLPAIN-------------------------------------G--------
--------YVPES------IPILG-FCFDDTVQWHFCSVGTQNDIFTIHFTGHSFIYGKR
HEDTLTLFPMQGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KKLRLRFRDAKCIRND-DDDSYEI-IYEPSG----ST--------------AMTTKK-IH
DSSEIE-DENDADSDYQDELALILGLRSFRNSSLNQEKDE-LNLTALALEKDS--EFIPP
SANRSLDSNSSSPSHVSR---------------------LIAKNFAESLKTLLHLEAPAA
GSPLEH-AGLDKNSALNPPMA---EHSSPYSEDPR-----------EDHPLSDVTGISLL
PF--GT-GFKNRKPAKHQRFQVGRGQAA-----------------KHKFSQTRFPAHKTR
TRLSQDNS-----------------SSSRMGPWEDIPSDLLLLQQKDPYKILNGEWHLVS
EKGSYEIIQDAN--ENK-TVNKLPNSPQN--DSRTWG-ENI--PFKNSHGKQSGHPTFLV
TRRKPLQDRQDRRNSRLKEGLPLIRTRRKKKEEKPAYHVPLSP-----------------
-----------------------------------------------------------R
SFHPLRGEVNASFSDRR-HNHSLLLHASNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LSIDLNQTFPSM-NLSLAASLPD
HDQTSPNDTTSQTSSPPDLYPTVSPE-----EHYQIFPIQDSDPTHSTTAPSNRSPDPTH
STTAPSNRSPPTQPSQI-PNYD-LR-NRAI--PTDVSQ-I-FPSLEL-EVWQTATSL-DL
SQPS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-ISPDLGQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1965)

MA

PF06049 // ENSGT00910000143988_0_Domain_14 (1965, 1972)

LSPDPGQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

E

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

SLSPDLGQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

SLSP-----------DLSQ

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

E

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

SLSPDLGQ

ENSGT00910000143988_0_Linker_18_20 (2010, 2012)

TA

PF06049 // ENSGT00910000143988_0_Domain_20 (2012, 2019)

LSPDPSQ

ENSGT00910000143988_0_Linker_20_22 (2019, 2020)

E

PF06049 // ENSGT00910000143988_0_Domain_22 (2020, 2046)

SL------------------S
PDLGQ

ENSGT00910000143988_0_Linker_22_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

SLSPDLGQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

E

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

SLSPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2066)

TA

PF06049 // ENSGT00910000143988_0_Domain_27 (2066, 2073)

LSPDPSQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

E-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

SLSP-DLGQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

SLSPDLGQTALSPDP-
------------------------------------------------------------
---------------------SQE

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

SLS--PDLGQTS----------

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

-LSPDLGQ

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

E

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

SLSPD
LGQ

ENSGT00910000143988_0_Linker_43_44 (2224, 2226)

TA

PF06049 // ENSGT00910000143988_0_Domain_44 (2226, 2232)

LSPDLSLESLSPDLSQ---------------------------------------
--------------------------------------------------------LDLK
QTSPPLDL-NQT-------------SHTSESSQS----LPLPEFGQTFP-------NA--
-----DIGQMP-SPPPDSTLNNTFKPEEFNPLVVV-GLSRD-DGDYIEIIPRQKE-ESSE
E---D-YG-EFEFVAYNDPYQTDLRTDINSSRNPDNIAAWYL-RSN--TGNRKYYYIAAE
EISWDYSKFVQS---DDV------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------D--YVPEDTVYKKVVF-RKYLDSTFTKLDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNKTYTYVWHATTRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLDKETNMPVDMREFVLLFMVFDEKKSWYYDKKP--TRSWRRASSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGEIQRAGMQTPFLIVDRECKMPMGLSTGLIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
QASEFWG-YWEPKLARLNNGGSYNAWIAEKLSTEFNPEPWIQVDMQKEVLLTGIQTQGAK
HYLKPYYTTEFCVAYSLDRKNWRIFKGNSTRNVMYFGGNSDASTIKE-NQIDPPVVARYI
RISPTGSYNKPALRLELQGCEVN-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----

MFPGCPPVWVLVVLGTS---WAGGGSPGADAAQLRQFYVAAQHVSWSYYHPEPANL-SLN
PFATSFKKIVYREYDAYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTMKIHFKNKADKPVSIH
PQGIKYSKFSEGASYADHTYPVERMDDAIAPGQEYTYEWIISEDSGPTPDDPPCLTHIYY
SHENLIQDFNSGLIGPLLICKEGTLSEDGTQKMVDKQHVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDIMLCAYDHVSWHLIGMSSGPEMFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSTGGRWTVSSL--TPKHL-QAG--MQAYINI
ENCPKKTRNPKKMTVEQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
EENL-NIKEDGILGPVIRAQVRDTLKITFKNM-ASRPYSIYPHGVTFSP----YEEVVVN
SSSNSGSHTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDITRDIASGLIG
LLLICKSRSLDKRGIQRTVTISYPSIALC-GNIYSYGFL--SCLFSSGPS--------LQ
KASLQS----NNVC-------------------------------------G--------
--------FSLDSRLTPHEIFFSSFQVFLNSVRYHLVKVYSSVSIFV---------IKNV
NTGLLSLSPLKNNSLILIIKANKNTWLEKSDMG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------IWKILTYQTRKGN
RQERHKT--F---LLPSSVLSFAI-IWLIFS----PS--------------FM-----LN
DINRFSVAMVKQDFSYEDILVSKFSD-------------------------LLRIGFHPP
CSQTH-------PRKSAT---------------------CLIPEYHLAKKKSPS--QTV-
--LCEL---------LHCCDA---RAMSCWPRFSV---------KIFLFLYRCLLGLLCF
SQ--SANDFNTQFDEFLQCFQHSHDATQ-----------------KHAT-IMNATQQDTT
THRQEHSG-----------------EILTYQGYETLLSCLFS--A----ANTSACWR-VH
ERGSYDPEDCAS--LV--SENSVLQNAF---MKPIYNYSHFLVKGREVEGDRRGGGKFN-
---------RGTANGGTTPVEHIVRVQI----YQVYNHFPLQRAADMEQQVVF-------
-AVFDENKSWYIEDNIN-KFCENPEEVNRDDPKFYESNIMSNFSLLWLKYDCALEAEMWV
RIHSLKSIAYPHFQYRHVVMKF-LT-----------------------------SGSAPV
----------AQVAKAPA---TCTPG-----LTNNFFRVSLPSNLNQKNG--------LV
IFLNATNRRILGKPHCY-FSLK-LT-FLCN------------------------VNP-EK
SI-------------------------PSSGA------------LQPSCGDSGEG-SNSS
LEISPGFFF---------------------------------------------------
----------FFKESKYSPCPGHIFGSLV---S-SFRP-VANRAYTIVGF----------
--------YNK-VYFPH----L--LPPILS-NFSLTK-------TGKDLELTICSFLKNL
AI------YT--EADGLQPSLDLLNNN--DKL----------------------------
------------HMLCGDTGGNNLLSFMIRESANTELKR--RIRGRFLDLLLLG-RRLEL
A----------RA---------------DFYNPLFSPILSNMS-QPGPF--PASLSPGFT
AQPH-PDH-----------------CCPS--NSS----FTPPSFQLFLP-------LPSS
CSFRKDQSHFPPGN----------LPYFFQPLLNVLGNCPS-RAS--RLTHTQQHLL--S
P---DVYLDLQVYVSL------------RLFEQPPHLFHLQI------------------
-SSADHNHFTGS---R--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EP----RNKHGVVFLEMVVKIKMVCPSYSAI--V
SKLSSHNH----LLWPINADMLGVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVPPNSSYTYVWHATGRSGPESPGSACRAWAYYS-SVNPEKDIHSGLIGPLLICR
KGTLDK-SNMPVDMREFVLLFMVFDEKKSWYYEKEP--KRPWRLASSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRFHLLNVGGSQDIHVVHFHGQTLLENGNQQH-QLGVWP
LLPGAFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLVIDKDCKMPMGLSTGLISDT

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLGSHWEPRLARLNNIGSYNAWSVEKHATESDSTPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTQFYVAYSSDRINWQTFKGNSTKNVMYFDGNSDASSIKT-NQFDPPIVARFI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPYRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAITTQGCTSLSSEMYVKSYTI
YYSDQGVEWKPYRQRS-SMVDKLFEGNVNTKGHMKNIFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGEIYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DRLETEDEEGDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDTIVGSNYSSPNNISR---------------------LTVNNFAEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GARELKNQEHAKHKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPGKQSGHPRFPR
VRHKSLQVRQDGGKSELKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRTEAYNTFSERR-LNHSLLLHKSSETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPELSEM-LEYD-RS-HKSF--PTDISK-M-SPSSER-EVWQTVT

PF06049 // ENSGT00910000143988_0_Domain_10 (1916, 1923)

SP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TVSPELSQTNLSPALGQ
MPM

PF06049 // ENSGT00910000143988_0_Domain_17 (1984, 1992)

SPDL--SHTTLSPDLSHT

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2008)

TLSPDL

ENSGT00910000143988_0_Linker_18_20 (2008, 2011)

SPT

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLSH

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2026)

TLSPDL

ENSGT00910000143988_0_Linker_21_22 (2026, 2029)

SPT

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TLSPDLSH

ENSGT00910000143988_0_Linker_22_23 (2037, 2039)

TN

PF06049 // ENSGT00910000143988_0_Domain_23 (2039, 2046)

LS
PDLSH

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDLSH

ENSGT00910000143988_0_Linker_24_25 (2055, 2057)

TN

PF06049 // ENSGT00910000143988_0_Domain_25 (2057, 2064)

LSPDLSH

ENSGT00910000143988_0_Linker_25_26 (2064, 2065)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2065, 2111)

TL----------------------------------
----SPDLSHT-TLSPDLSHTS--LSPDLS-HTILSPD-LSPT-----------TLSPDLSHTN---LSPDLSHTTLSPDLSQTNLS--PALDQMPMSPD-LSH-TTLSPDLSHTNLSPDLSHTTLSPDL---------SQTNLSPALGQMPMSPDLSQ--TTLSPDLSHTTLS-PDL--S----------QTNLSPELSHTNLSPA--LSQMPLSPDLSQVTVSPDIS--ETTLLPDLSQISPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP-------DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSED---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAEEISWDYSEFVQR---ETD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEDSD--DVPEDTVYKKVVF-RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRVTSSEVK------KSHEFHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWALLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDSQIKASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIGNKQITASSFKKSWWG---DYWEPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTIHYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWNQSIALRLELFGCDVY----

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2111)

TL--------------------------------------SPDLSH

ENSGT00910000143988_0_Linker_27_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TLSPDLSH

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TS-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-H

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

T

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2141)

ILSPD-L

ENSGT00910000143988_0_Linker_32_36 (2141, 2155)

SPT-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALDQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2217)

TN

PF06049 // ENSGT00910000143988_0_Domain_43 (2217, 2224)

LSPD
LSH

ENSGT00910000143988_0_Linker_43_45 (2224, 2225)

T

PF06049 // ENSGT00910000143988_0_Domain_45 (2225, 2242)

TLSPDL---------SQTNLSPALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_49 (2254, 2262)

SPDLSQ--

ENSGT00910000143988_0_Linker_49_50 (2262, 2263)

T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TLSPDLSHTTLS-PDL--
S----------QTN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSHTNLSPA--LSQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DVPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRVTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFPLGPRLCLWVVLGTS---CAGWGSPGAKAAQLRQFFVAAQVIPWSY-RPEPIDP----
--RSSFKKIVYREYEPYFKKEKPQPSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 199)

LLGPTLYAEVGDTMQVHFKNKADKPVSIH
PQGIKYSKLSEGASYDDHTSPVEKMDDAVLPGGEHTYEWVIGEDSGPTRDDPACLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHILLFAVFDESKSWIQ-------
---------------SPALMYTVNGYVNRTMPDIMVCAHDQVSWHLIGMSSGPELFSIHF
NGQVLEQKNHKVSAITLVSATSTTANMTVSPEGKWIISSL--IPKHF-QAG--MQVYIDI
KNCPKKTRKPMILTQDQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPMIPANMDKKYR-------SLHLDNFSNQIGKHYKKVIYKQYQDETFTKR
MEN---NKQNGILGPVIRAQVRDTLKIVFKNM-ASRAYSIYPQGVTFSP----YEDEVNS
SFTSGS-HTMIRAVQPGETYTYKWSILELDEPTENDAQCLTRPYYSDVDITRDIASGLIG
LLLICKGRSLDQRGIQRAADIEQQVVFAVFDENKSWYIEDNINKFCENPEEVKHDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMSSSSRS
KNLRLRFRDVKCVRAD-DDDSYE--IYEPAV----PT--------------AMSTRK-MY
ESSENDHKENDADYDYQDILALSLGIRSHRNSSLSQETDE-FNLTALALESSS--ELVSP
STNATSASDSSSPRNLSG---------------------LSDNHPKEPQKAPPLSEASSD
GPLSEYLPGLDKNLVPSPPTK---ELSSPYSINHM-----------EDHLQSDITEIHLL
PP--GTKGLSHEEHTKSKVSKVKRHPGV-----------------KHRFSWKRSPGHRAG
RHSNPDNT------------------SSRMGYWEDIPTDLLLLKQKNP-KILNSEWHLAS
EKGSYEIIQDNG--EGA-TPGKLLNSPQN--NSRAWG-GSI--PPTNESGKQSDPPKLSG
VRQKFLQVRQDKENSGLKKSPFLIKTRKKNKN-KYLPHLPLSP-----------------
-----------------------------------------------------------R
GFHPLKGGI---------LNHQQIPHKPKDIA-----LATDFNQTSPFM-STDRKASLPE
HNQTPPNNT-NQISSPPGLYKTVSSE-----AYLPTFPVQDPDQAHLTTGPSH-------
-------RSSPPEHTLV-SGYE-LS-HEFY--PVDITPTT-PP-------WKHF-IS-DR
NQLS---------------------LSSDQDQL-PLSSDLSQTTFPSDLSQTTSPSDHSQ
MTSS--------------------------------------------------------
-------------------------------------S-DLSLLTNSPEFDQTSLSVEVG
EMP-------------------------------------------PPSVLGQMPLSPDY
SQTA---SSPDLSLLNLSPEFDETNLS--EELGEMPPPAV-LGQ-MPVFPDLSQTTFSSD
LKF-------------------------DQTSPSPDLGQ--MPFSSDLRQIASS-PDH--
N----------QGAFSSDLS-LLVSPE--LDQTNLSPDLSQVTLSPDLS--QTVPPPNLS
QVPPLPDP-GQT-------------PHPPL--QS----SSLPELDQIFP-------YS--
-----DFIHVP-----SPELNDTFMLEENNPIVVV-GLSKV-DGEHIDIIPTQDE-ESGE
D---F---VELDYVTYDDPYKTDIRTDVNSSRNPDNIAAWYL-RSH--NGNRKYYYIAAE
EISWDYSKFAQR---QMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SEDTD--NIPKDTTYRKVVF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNASYTYVWHATERAGPESSGSACRVWAYYS-AVNAEKDIHSGLIGPLLICQ
KGTLHKESNMPVDTRDFFLLFMVFDEKKSWYYKKS---ERSWRPESPEVK------NSHQ
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGSSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKECKMPMGLSTGVIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
TASEHLR-YWEPRLARLNNGGSYNAWSIEKHTSESDSQPWIQVDMQKDVVITGIQTQGAK
HYLKSYFTTEFYVAYSSDKTNWQIFKGKSTKNVMYFNGNSDASTIKE-NEFDPPIVARYI
RITPTKSHNRPALRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSAPLGMETGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSHARLNAQG-RVNAWQAKANNNRQWLQVDLLKVKKITAISTQGCKSLTSEMYVKSYTI
QYSDHGVQWKPYRQKS-SMVDKVFEGNSNTKGQVKNFFNPPILSRYIRII-----PKTWN
LSIALRLELFGCDIN---------------------------------------------
-----

------------------------------------------------------------
-----FKKISYREYEVDFKKEKPADKS--TG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLRAEVGDTLIVHFKNLADKPISIH
PQGLVYNKKAEGSLYEDRTTSVEKQDDAVLPGQVYTYVWDITEEVGPREADLPCLTYAYY
SHENMVTDFNSGLIGALLICKKGSLNEDGSQKLFDKEYILMFGVFDENKSWQR-------
---------------STSLKYTINGYANGTLPDLEACMYDNISWHLIGMSSKPEIFSIHI
NGQVMEQRHHRISTVNLVGGASTTVNMTVSEEGRWLISSL--VQKHL-KAG--MHGYLTV
RDCGDRQVKKSRLSLKERRMIKNWEYFIAAE-----------------------------
---EVVWDYAPTIPDSLDKHYK-------AQHLDNYSNLIGKKYKKAIFRQYTDGSFTKR
LENP-RPKETG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 566)

ILGPVIRAQINDKVKIVFKNK-ASRPYSMYFHGVTLSK----DAEGANY
PQDPTGNATQSKGIQPGKTYTYEWQIAKTDQPTAQDAQCITRLYHSAVDIEKDIASGLIG
PLLICKSEALSQKGVQKKADGEQHAMFAVFDENKSWYIEDNIKEYCSNPASVRRDDLKFY
NSNIMHTFIL-AIN-------------------------------------G--------
--------YVTDR------NEILG-FCQDNVVQWHFSSVGTQDEIVSIRLSGHAFLYRGK
YEDVLNLFPMSGESVTVE----------MDNIGKSS-------------SKLSFR-PQSI
RIYKNRKPFQIHTVPADMYEALLAAQALSTYIIACADTEVLLVVLCAFGFFFLQFTIRIG
VSNSHFKVLKLIQDSQITLVTVEQSGYTLPQVIGHLAAVKSAMLNQVSLFCLKYQSHSLK
SLSVQDQGITKNPS------DLMTTSPLINRI-SAWLWYAICFHHLDHVNLLLLEIEKTM
QVAVCLFSDSIFLYSVTFASSKSKYTTSKELDAIDPSFKW--KTSSSNLKILVIPPKPSH
LDAEAGSLIFV---Y-------RSSC----------------------------------
-----------------------------------MN-------SKAFKIPSSWGSTEMS
YGMRVRFRDVRCDYEDDSL--FDIVDF---T-------NTKT--------DKKALSTSVE
EDVGEEVD--EDDSEYQDLLASFYSIRSLRNAGETEET---QNLTALAWGQSE--DINTA
SSK----------------VVVDSDLTVTNDS-----------KLTEFLEARTAPPLQTE
TE-------------------------------TFQSN-TSVTAEEYLLLASASDGKPNL
IF-----ENRSR----------------------------------SGYA----------
E------------------------NHSNMSGGEHFLSN--------------GEAQVK-
--DAEEPLTDRK--------DSNSFTEEHQ-----------------EESTGKRNNSIN-
-------------SKRKKRSSVAIKFYSVQKMKALLNHVR-NKNVSFSDKTNT-------
------------------------------------------------------------
---PN-------------------------------SMQHTENTSSTATVADDQHPSDYD
DDLEEEETK----------------GGNAMHAGNLTVELEVTVEENAS-NAS--------
------------------------------------------------------------
--------------------------------------------------------SLSQ
LELSKDKQTDLFSLDHTLG--------------------------------------NIR
PNS------------------SPALVKNFLEAS--LPR------------T-V-------
--KYS----------------------------------------------------SKM
TDEEWNLVSAK-GIQRLEANLDKSI-----------------------------------
------SGKLNYGGRNG------TI-FLNKKH---------MKKDGGFSHLKGE------
-----------KHKGNHKR------PP-----LKRKEGNKNDTLST-----SGTFVKIRR
KKKEYPKT-TQ--------------FLNPRSKKPQKFTKPTEELGRTLFPGGANHVTLPC
CTNTTES---------------PSDTQQLKPSIVI-GLPHE-NGNYE-YTSGEYYSEGTS
G---D--EYEYYYVSFDDPYMTDPKLNVNEQRNPENIAEHYL-RS---RGNERRYYIAAK
EVCWNYAGLKKSTMM---Y-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DKICKDGSTKKVIF-QRYTDSTFTILQDE
GEYEEHLGILGPVIRAEVNDVILVHFKN-LASRPYSLHAHGLFYEKSSEGSIYDDESSDW
FKEDDKVQPNSSYIYVWYANRRSGPLQPGAACRSWVYYS-DVNLEKDTHSGLIGPILICE
KGTFSAPENNGTNTRDFFLLFMVFDEEKSWYFDKRS--RKPCTEK

PF07731 // ENSGT00910000143988_0_Domain_65 (2926, 3043)

TREMQ------QCHK
FYAINGITYNLQGLRMYEGELVRWHLLNMGVPKDIHVVHFHGQTFTEQLELMKFQHGTYT
LLPGSFQTVEMKPQRPGWWLLDTEVGEYQQAGMQASFLVLEK

ENSGT00910000143988_0_Linker_65_66 (3043, 3059)

ECKIPMGMASGVILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
NASHHID-YWEPKLARLNNSGTYNAWSTAM-T---NDLPWIQVDFQRQVLLTGIQTQGAR
HFLKSFYVQKFFIVYSRDKRKWNTFRGDSSPAEKIFEGNSDAYSIKE-NVIDPPIIARYI
RVYPTQAYNEPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVDG--CSLPLGMESGKIKNT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSVKTSWFS----TW
EPSLARLNQKG-KINAWRAKSNNNQQWLQIDLLTIKKITAVATQGVKSVSAENFVKTYVI
LYSNQGSEWKSYTEGS-NSVAKVFSGNENSNGHVKHFFNPPILSRFIRIV-----PKTWY
NGIALRVELFGCDFGGDLTAKRTEKSGT--------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGVSWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEQMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGEIYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISR---------------------LTVNNFAEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHNGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPGKQSGHPRFPR
VRHKSLQVRQDGGKSGLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRNEAYNTFSERR-LNHSLLLRKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSER-EVWQTVT

PF06049 // ENSGT00910000143988_0_Domain_10 (1916, 1923)

SP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSSELSQTNLSPALGQ
RPM

PF06049 // ENSGT00910000143988_0_Domain_17 (1984, 1992)

SPDL--SQTNLSPALGQMPMS------------------------------------
------------------------------------------------------------
-----------------------------------

PF06049 // ENSGT00910000143988_0_Domain_32 (2136, 2143)

-PD-LSH

ENSGT00910000143988_0_Linker_32_36 (2143, 2155)

T-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSQ-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSHTNLSPD
LS------------------------------------Q--T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TLSPDLSH

ENSGT00910000143988_0_Linker_50_48 (2271, 2272)

T

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2293)

TLS-PDL--
S----------Q

ENSGT00910000143988_0_Linker_48_51 (2293, 2295)

TN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSHTNLSPA--LGQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DVPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MLLVCPRLCVLVVLGSS---WAGWGGSGTEAARLRQFYVAAQGINWSY-RPEPTDP-SLN
S-KTSFKKIVYREYEPYFQKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYPDYTFPVERMDDAVAPGREYTYEWVISEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKRGTLSDDGTQKMFDRQHVLMFAVFDESKSWSQ-------
---------------SSSLMYTVNGFVNRTMPDITVCAHDHISWHLIGMSSGPELFSIHF
SGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWIIASL--TPKHF-QAG--MQVYIDI
KNCPKKTRNTKILTREQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPVIPLNMDKKYR-------SMHLDNFSNQIGKHYKKVIYRQYEEE

PF07732 // ENSGT00910000143988_0_Domain_3 (476, 566)

TFTKR
TENP-SIKENGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGS-HTMIRPVQPGETYTYKWNILEFDEPTENDAQCLARPYYSDVDITRDLASGLIG
LLLICKSRSLDQRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------YVPES------IATLG-FCFDDTVQWHFCTVGTHDDILTIHFTGHSFIYGKR
HEDTLTLFPMHGESVTVT----------MDNIG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRS
KNLRLRFRDVKCIPNDDDEDSYE--IYEPLA----AP-------------TAMTTWK-MS
ESSENEQEEDDPDYDYQYTLASSLGIRSFRNASLNQEEDE-FNLTALALENSSREEFISP
STDIVIGSKSSSLRNLSK---------------------LVDSNLKEPQKTLLHSGSTTT
STLLEHLTGLDKNSSLNPSIE---EHSSPYSENHM-----------EDP-QSDIIGISLL
PP--GAKGLTNHDQVKHALSEAQEHQVV-----------------KHRFSWMKGPARKTG
KHSRPKST-------------------SRMGLSEDSPSVLLLLKQNNPSKILNREWHLAN
EKGSYEITQDNG--KDV-AFKKLLDSPQNQNISMIQG-DSI--PATNKTGKPIDLPNYSA
VRHKALQVRQDEENKHLKKRPFFIRTRKKKKDKKHAHHSPLSP-----------------
-----------------------------------------------------------R
GFHPLRRDAHPMFLDRK-VNHTLLLHKPNGTA-----LATDLNQTFPSM-NIDKEISLLD
HKQSPPHNT-GQMRSPIGLDQSVLPE-----EHSPKLPVQDSNQTQSTIGSSH-------
-------RSSPPEPSQV-PDYD-LR-YEYH--LVDTAQ--------------ASSFP-DQ
SQPS----------------------LSSDHSQTA------------------SSPDLGQ
MPLSPDHSQ--TTSSPDLGQMPLSPDHSQTTSS---------------------------
-----------------------------------------------PDLGQMPLSPDQS
QTTSSPDLGQM-PLSPDHSQTT--SSPDLG-QISF-------------------------
------------------------------------------------------------
------SPDHSQMTPSPDLSLLTLS---------PETDQ--TILSPDLDQMLLF-PDD--
N----------EMTLSPDLSLLALSPE--FDEIILSPDLSQVTLSPDLI--PETPLLNHG
QMSPPPEP-GQI-------------PYPSDSVQS----SPLPELSRISP-------SP--
-----DLIH-MPSPSPSPTHN----EKKLNPLVIV-GLSRV-DGDDIEIIPREEV-ESTE
D---D-YA-EDDYVAYNDPYQTDTRTDISSSRNPDNIAAWYL-RSH--DGNRKYYYIAAE
EISWDYSKFAHS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDIDNEDTPKDTTYKKVVF-RKYLDNTFTKRDPQ
GEHEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDESPEW
FKEDNAVQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNMEKDIHSGLIGPLLICQ
KGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKS---KRSWRSKSSEGQ------NSHE
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGDSRDIHVVHFHGQTLLENGSQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLN-YWEPKLARLNNGGSYNAWSIEKPALELASKPWIQVDMQKEVIVTGIQTQGAK
HYLKSYFTTQFYVAYSSDQTNWQIFKGNSTKNVMYFEGNSDASTIKE-NLFDPPIVARYI
RISPTNSYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGNIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DFW
EPSRARLNAQG-RVNAWQAKANNNKQWLQVDLLRTKKITAIVTQGCTSLSSEMYVKSYTI
HYSDQGVEWKAYRQKS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

-----------LLLGSW---WPDSEQHVVGAVKIREHYIAAQITSWTY-KPEPEEKSRLE
HSGPVFKKISYREYEVDF

PF07732 // ENSGT00910000143988_0_Domain_0 (79, 202)

KKEKPANTF--TGLLGPTLHAEVGDTLVVHLKNMADKPVSIH
PQGLVYSKNEEGSLYDDRTSSAEKRDDAVLPGQLYTYVWDISEEVGPGEADLPCLTYAYY
SHENMAMDFNSGLIGALLICKKGSLNEDGSQKHFDREYVLMFGVFDENKSWQK-------
---------------SASVKYTINGYTNGMLPDLEACAYDNISWHLIGMSSKPEIFSIHI
NGQSMEQKHRRVSAVNLVGGASTTVNMTVTEEGRWLISSL--VQKHL-QAG--MHGYLTV
RDCGDKEVKKNRLSYRERLMVKTWDYFIAAE-----------------------------
---EVTWDYAPSIPDTLDRHYK-------SQHLDNFSNLIGKRYKKAIFTQYTDASFTKR
LENP-RPKQTG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 606)

ILGPIIRAQINDKVRIVFKNK-ASRPYSIYFHGVTLAK----NAEGADY
PLDPTSNGTQSRGVEPGNTYTYEWKIAKTDQPTAQDAQCITRMYHSAVNIERDIASGLIG
PLLICKSEALTQKGVQKKADEEQQAVFAVFDENKSWYLEDNIKEYCSNPATVKRDDPKFY
NSNIMHT-----IN-------------------------------------G--------
--------YVSDS------SEILG-FCRDTVVQWHFFSVGTHDELVSVRLAGHFFLYQGK
YEDTLSLFPMSGESVTVE----------MDNGG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWLLASWGTPEMS
YGMRLRFRDAKCDYEEDET--FDE------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------HQ-----------------EQSPGRGNYTTN-
-------------QRRKRRSSLAIKFYSVQKMNTLLNHVR-NKNVSFSGKTDV-------
------------------------------------------------------------
---PL-------------------------------SVHHTENTSNEAMVGTGQLPNEHD
DDLEEEGKK----------------ME---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------NVIFDDPYMTDPKVNISRQRDPDDIAEHYL-RS---RGNKRRYYIAAK
EVCWNYAGYKKSAMR---N-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DKTCKDGSRHKVIF-QSYTDSTFSTLQDE
DEYTEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2880)

ILGPVIRAEVDDVILVHFKN-LASRPYSLHAHGVLYEKSSEGSVYDDESTAW
FKE-DEVQPNNSYIYVWYASQRSGPLQSGAACRSWIYYS-DLNLEKDIQSGLIGPILIC

ENSGT00910000143988_0_Linker_61_65 (2880, 2953)

E
KGSFSKSNSSRTYTRDFFLLFMVFDEEKSWYFDKHS--GRPCNEKTREMQ------QCHK
FYAINGITYNLQ

PF07731 // ENSGT00910000143988_0_Domain_65 (2953, 3040)

GLRMYEGETVRWHLMNMGGPKDIHVVHFHGQTFIEQGEP-EHQLGTYT
LLPGSFRTIEMKPQRPGWWLLDTEVGEYQQAGMQTSYLV

ENSGT00910000143988_0_Linker_65_66 (3040, 3059)

IEKECRIPMGLASGVILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
DASHHID-YWEPKLARLNNYGTYNAWSTTV-E---EELPWIQVDFRRQVLLTGIQTQGAK
QFFKSLYIQKYFLVYSKDKRTWNTFKGDSSPTGKIFEGNSNAYEVKE-NIIDPPIIARYI
RLYPTEVYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVDG--CSLPLGMESGEIKNT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSTKTSWFN----TW
DASLARLNQNG-KMNAWRAKFNNNQQWLQIDLLTVKKITAIATQGVTSMSAENFVKTYVL
LYSNEGSEWKSYIEDS-SSMPKVFLGNANSNGHVKNFFNPPILSRFIRIV-----PKTWY
RGIALRVELYGCNFGGGLAVKRIDESGRS-------------------------------
-----

MFPGCPRVWVLVVLGTS---WVGWGSQGTEAAHLRQFYVAAQGISWSY-RPEPTNA-SLN
HSATSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIKYSKLSEGASYLDHTFPVEKMDDAVAPGQEYTYEWSISEDSGPTQDDPPCLTHIYY
SHENLIEDFNSGLVGPLLICKEGTLTEDGTQKMFDKQLVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYANGTMPDITVCAYEHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRRLKKITREQRRHIKRWEYFIAAE-----------------------------
---EIIWDYAPVIPANMDKKYR-------SLHLDNFSNRIGKHYKKVIYTQYEDESFTKH
IENP-HMKEDGILGPIIRAQVRDTLKIVFRNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGS-NTMIRAVQPGETYTYKWNILELDEPTENDAQCLTRPYYSNVDMMRDIASGLIG
LLLICKTRSLDKRGIQRAADIEQRAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPNFY
ESNVMSSFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWILTTMNSSPRS
KKLRLKFRDVKCIRDD-YEDSYE--IYEPQE-----S-------------SVIATRK-MH
DPSENEDEESDADYDYQNRLASALGIRSLRNSSLNQKEEE-FNLTALALENNS--EFISP
NTDVTVGSNYSSPMKISK---------------------LTVNNLAEPQKTPSHQQATIA
GSPQRHL--IGKNSVFHSSTA---EHSSPYSENPI-----------EDPLESDVTGIHLL
SL--GAGEFRSQEHPKHKEPKVKRDQAA-----------------KHRFSWMKSPADKIG
RHLSQYNG-----------------S-SRMRPRKDLPSDLLLLKQKNPSKILVGKWHLAS
EKGSYEVIQDTD--EDT-AVNNQLISPQN--ASHARG-EST--PLTNKPGKPSGQPEFSR
VRHKILQIRQDGGNSGLKKSQFLIKTRKKRK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
AFHSLRSEAYNPFSERR-FNHSLLLHKSNKTS-----FPIDLNQTLPSV-DFGWILSLPD
HNQNSSNDT-DQTSSPPDLYQSVPPE-----EHYETFLIQDLDQMNSTSDPSH-------
-------RSSSPELSEI-FDYD-QN-HKSF--PTDISQ-M-SPSSEH-EVCQT-------
------------------------------------------------------------
------------------------------NL----------------------------
----------------------------------------------SPELGQIPLSPDIS
QMTISPELSQT-NLSPELSHTT--VSPELS-ETNRSLD-LSHM-----------NLSS--
----------D-------------------------------------------------
-----L--S----------------P---------ELSE--MPLFVDLSQIPLS-PDL--
D----------QMMLSPDLGETDLSLD--FGEVSLSPDLTQVTLSPDLS--ETILLPDLR
QISPPPDL-SQI-------------FYPSESSQS----LLIPEFNETFP-------YS--
-----DLGRTP-SP-SSPTLNDTFLLKEFNPLVIV-GLSKD-GTDYIEIIPREEV-QSSE
D---D-YT-ETDYVSYDDPYKTDVRTNINASRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ERD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDID--NTPENTIYKKVVF-RKYLDSSFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPAW
FQDDNAVQPNSSYTYVWHATERSGPESPGSACRAWTYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKESNMPVDMREFVLLFMIFDEKKSWYYEKKS--RMSWRLTATEVK------NSHE
FPAINGRIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKRH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSTEKLAAEFASKPWIQVDMQKEVLITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3261)

LQGCEVNETCCSTPVGSCN-------------------------
----------------TSLR

PF00754 // ENSGT00910000143988_0_Domain_68 (3261, 3369)

ANNNKQWLQIDLLKIKKITAIITQGCKSLSSEMYVKSYSI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLLGCPHLWVLVVLGSC---WAGWGRHRADAAQLRQFYVAAQGINWNY-HPEHSNL-SSN
PFTTFFKKIVYREYEAYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGVKYSKFSEGASYPDHTSPVEQMDDAVAPGQEYTYEWHIGEDSGPTQDDPPCLTHIYY
SYVNLIQDFNSGLVGPLLICKKGTLTEDGTQKMFDRQHILLFAVFDESKSWAQ-------
---------------SSSLMYTVNGYVNRTMPDIAVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQGHHKVSVLNLASATSTTANMTMSSEGKWIISSF--IPKHF-QAG--MQAYIDV
KNCPKKTRNPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKYYKKVVYKQYQDETFTKR
VENS-NIKEEGILGPIIRAQVRDTLKIVFKNM-ASRVYSIYPHGVTFSP----YEDEVNS
SYTSGS-HTMIRAVQPGETYTYKWNILELDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDKRGIQKAADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
QSNIMSTLTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYEKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMITTMNSNPRS
KNLKLRFRDVKCIRDD-DDDSYD--FYEPIA-----P-------------TVMGTRK-MH
DSSENKQEEDNPDYDYQDKLASEFGIRSFRNSSLNQEEDE-FNLTALALEDSS--EFIFP
SRDTAIGSNSSSPSNVSR---------------------LIANNLTEPQKTLPHPGATRV
DPPRRYLVGLGENSVINSSMT---EHSSPYSEDPL-----------EDHLQSDVTGISLL
PP--GAKGLRSP----------ERDQVA-----------------KHRFSWMKLPAYKFG
RHLNHGNT------------------SSRRKPWKELPSEPLLLKQKNPSKTLNGKWHLVS
EKGSYEIIQDTD--EDV-AVGKLPNNPQN--VSRMWG-GSI--PPIDKPNKPSDHPKFPG
VRHKSLQIRQDGGNSGLKKRPFLIRTRKKKKEEKLAYHVPLSP-----------------
-----------------------------------------------------------R
GFNPLREKSYNTFSERI-FDHSLLPPKSNETS-----LLEELNQTSTSA-NFGWTVSLLD
HNQNTPNNT-SQTSYH

PF06049 // ENSGT00910000143988_0_Domain_6 (1817, 1822)

PDLSQTVTPE-----EHYHTFPIQDPDGTHSTADPSH-------
-------RSSPPELSQM-LDYD-LS-HEFH--PADTGH-M-SPSLEP-EGWQTTLSP-DP
NYPF---------------------LYSDQGQMT

PF06049 // ENSGT00910000143988_0_Domain_13 (1955, 1963)

SSSPDLSK

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TPSPDLSQI--------
------------------------------------------------------------
--------------------------------------------AVPPVLYQM

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

PPSPDLS
QTTPSLDLGQR-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TLSPELGQTS--LDPDEG-QI

PF06049 // ENSGT00910000143988_0_Domain_35 (2134, 2163)

TLSPE-LG-------------------
-QIN---LDPDLDGM

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPELGQTNLD---------------------------------
----------------------------------PYGGQ--VA

PF06049 // ENSGT00910000143988_0_Domain_50 (2264, 2271)

LSPELGQTNLD-PDE--
D----------QI

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2302)

TLSPELGQINLDPN--GGQMPLSPGLSQM

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDLG--QTIHLPKLS
PTLP

PF06049 // ENSGT00910000143988_0_Domain_57 (2345, 2352)

PPDL-DHT-------------AYPSESNQL----LPLSEFSQTFP-------YP--
-----DSVHMP-SPLPSPTLGDAFVSEEFNPLVVV-GLSGD-DGDYIEIIPRKEV-QSIE
E---D-YV-EVEYVAYDDPYQTDTRTDINSSRNPDSIAAWYL-RSN--NGNRKYYYIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--DIREDTTYKKVVF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDVHSGLIGPILICR
KGTLHKESNMPMDMREFVLLFMVFDEKKSWYYEKS---KGSQRRESSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGSSQDIHVVHFHGQTLLEHGTQKH-QLGVWP
LLPGTFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLS-YWEPKLARLNNAGSYNAWSVEKIATEFASKPWIQVDMQKEVVVTGIQTQGAK
HYLKSCYTTEFQVAYSSDQTNWQIFKGNSTKNVMYFDGNSDASTIKD-NKFDPPIVARYI
RIFPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
YYSDQGVEWKPYRQKS-SIVDKIFEGNSNIKGHVKNFFNPPIISRFIRIV-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNS-SLN
LSVTSFKKIVYREYEPYFKKEKPQSTI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNLKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEE-FNLTALALENGT--EFVSS
NTDIIVGSNYSSPSNISK---------------------FTVNNLAEPQKAPSHQQATTA
GSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNWLISPQN--ASRAWG-EST--PLANKPGKQSGHPKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LKHSLVLHKSNETS-----LPTDLNQTLPSM-DFGWIASLPD
HNQNSSNDT-GQASCPPGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------RSSSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTVISP-DL
SQVT---------------------LSPELSQT-NLSPDLSHTTLSPELIQRNLSPALGQ
MPISPDL--SHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLS
LDFSQTNLSPELSHMTL-------------------SP-ELSQTNLSPALGQMPISPDL-
-S---------------------------------------HT-----------TLSLDF
SQTN---LSPEL---------SQTNLS--PALGQMPLSPD-PSH-TTLSLDLSQTNLSPE
LSQTNL------------------SPDLSEMPLFADLSQ--IPLTPD----------L--
D----------QMTLSPDLGETDLSPN--FGQMSLSPDLSQVTLSPDIS--DTTLLPDLS
QISPPPDL-DQI-------------FYPSESSQS----LLLQEFNESFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMK------KSHE
FHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSEQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MSPGHACLWVLLALGAG---LAGWGVRAGLVRGLRQFYVAAQSVTWTY-RPEPPDP-SLN
PFTPSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDLMKVHFKNKADKPISIH
PQGIKYNKFSEGASYSDHTSPLERMDDAVAPGQEYTYEWFISEDSGPTQDDPPCLTHIYY
SYENLTEDFNSGLIGPLLICKKDTLTEDGTQKMFDKQHVLLFAVFDESKGWNP-------
---------------SPSLMYTVNGYVNQTMPALTVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKVSAVTLVSATATTANMTVSPEGKWTISSL--IPRQF-QAG--MQAHIDI
INCPKKTRTTTKLTREQRRYIKRWEYFIAAE-----------------------------
---EMMWDYAPIIPTTMDKLYR-------SLHLDNFSNQIGKMYKKVVYRQYQDEGFTKR
MDNT-KMNENGILGPIIRAQVRDTLKIVFKNS-ASRPYSIYPHGVTFSP----YEDEVNS
SSTSGN-HTMIRAVQPGETYTYKWNILESDEPTDSDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQQVVFAVFDENKSWYIEDNINKFCENPDMVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTVHFTGHSFIYEKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRN
KGLQLRFRDVKCMRDD-DEDSYE--IYEPLS-----P-------------TAMAVRK-IH
SPSENEDEETDPDDDYQDILASSLGIRSFRNSSLDHKEDE-FNLTALALENSS--ELISP
STNVSIGSSSSS----SR---------------------TTVSNHTEPQKTLPHAGASTT
GHLLEHLSGLDKNPVVNSSTE---EYSSPYYEDQI-----------EDPLQSDVTEISLL
----GAKGFRDGEYAKHKAYRTKRNQLA-----------------NHGFFWMILPAHKTG
RHSNQDDT------------------SSRMGPLEDLQSDLLLLKQKNPSKILDGKWHVVS
EKGGYEIIQDID--KDL-AINELLNSPQN--VSKIWR-ERI--PPENNPGKQNDHPKFSG
VRHKSLQVRQHGENSGLKKRPFLIRTRKKKKEPKLAHHTPLSL-----------------
-----------------------------------------------------------R
GIYPLKGADYTTFSDRR-LNHSVLLHKSNETS-----LPIDFNQTSPSI-NLVQIGSLPD
HNLRPPNDT-GQTSSPPDLYQTVPPE-----ERYQTSPTQDPDQMHSTTDPSH-------
-------RSSPPELSQM-FNYD-LS-HELH--PVDIGQ-L-SHALEH-EAWQMTISS-GL
SQPS---------------------SSSSQGQTT----------PSSDLRQMITSPDLGR
IPLSSDFSQ---MPSPDLGQMPLSPELGEA------------------------------
----------------------------------NPSP-DLSQKTPSPEFSQMPLSPELG
ETS---------------------LSPH--------------------------------
FSQM---PSPDLGQMPLSPELGEASPS--PDFSQM-PSPD-LGQ-MPLFPELSEANLSPN
LSQKTPAPDLS---------QIPLSPEFGEANLSPDLSQ--KTPALDL--------K--S
G----------EAKFSPNVSQMTPSQD--LNKIPYSPGLSQVTLSPDIS--EKTLPPNFK
QTSHPSDL-DQI-------------SYPSESSQL----LPLSEFNQTSP-------YP--
-----DLVHMP-SPLPSPTLNDTFISNEFNSLVVV-GISGD-DGDYIEIIPQQEV-QISE
E---D-YA-EIDYVAYDDPYQTDRRTDINSSRNPDNIAAWYL-RSN--KGNRKYYYIAAE
EIFWDYAEFAQS---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SEDGD--DIRKDTTYKKVIF-RKYLDSTFTKRDPR
GEYEQHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLAYEKSSEGKTYEDDSPEW
FKDDNAVQPNRSYTYVWHATDRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGTLHKQSNIPVDMREFVLLFMVFDEKKSWYYGKS---ERTWKLESSEVK------NSHE
FHAINGKIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGSQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLR-YWEPKLARLNNGGSYNAWSVAKSALETSSKPWIQVDMQKEVIVTGIQTQGAK
HYLKSCYTTEFHVAYSSDRTSWQIFKGNSTKNIMYFEGNSDASTIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMEDGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRQKS-SMMDKIFEGNGNVKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELYGCNIY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DPLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISK---------------------LTVNNFAEPQKTPSHQQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPGKQSGHPRFPR
VRHKSLQVRQDGGKSGLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRTEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSLNDT-RQTSSPPDLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPDLSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSER-EVWQTVPSV-DL
SQVT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALSQ
MPMSPDL--SHT

PF06049 // ENSGT00910000143988_0_Domain_17 (1993, 2001)

TLSPDLSH

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2008)

TLSPDL

ENSGT00910000143988_0_Linker_18_20 (2008, 2011)

SPT

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLSH

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

T

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2026)

TLSPDL

ENSGT00910000143988_0_Linker_21_27 (2026, 2029)

SPT

PF06049 // ENSGT00910000143988_0_Domain_27 (2029, 2111)

TL----------
------------------------------------------------------------
----SPDLSH

ENSGT00910000143988_0_Linker_27_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2119)

TLSPDL

ENSGT00910000143988_0_Linker_33_34 (2119, 2124)

SPTT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-H

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

T

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2141)

ILSPD-L

ENSGT00910000143988_0_Linker_32_36 (2141, 2155)

SPT-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSQ-

ENSGT00910000143988_0_Linker_40_42 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_42 (2207, 2224)

TLSPDL--------
-SHTTL-----------------------------------------------S-PDL--
S----------QTN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSHTNLSPA--LGQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVHR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

TMAFLPKYLLLMFLGFS---WPGLKNSSVLAARIREHYIAAQVASWNY-SSLLEEPSRAS
DSDSLFKKIIYTEYETDFKKEKPRSALSGLG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LMGPTLRAEVGDTLIIHFKNLAEKPLSIH
PQSTAYHKHSEGSSHFDRTSPNESVDGAVPPGQMQKYTWEVTAKTGPRQGDPPCLTYAYY
SHVNMVQDFNSGLIGALLICKEGSLNEDGTQKQFNKEYVLMFAVFDESKSWQR-------
---------------TESIMYTINGYVNGTLPDVQACSYDRISWHLIGMSSGPEIFSIHF
NGQTLEQNQYKESTINLVGGASTTANMSVSNTGRWLISSL--VPRHL-QAG--MHGYLNI
EDCGNPDTLTKKLSYKELRMIKDWDYFIAAE-----------------------------
---EIVWDYAPEIPDNIDRKFK-------AQYLENFSNLIGKQYKKAVFRQYK

PF07732 // ENSGT00910000143988_0_Domain_3 (474, 607)

DESFSKR
IDKV-WSKERGILGPVIRAQVRDKIRIVFKNM-ASRPYSIYVHGVTLSK----EAEGAIY
PSDSKENLTQGRAVQPGETYTYKWIVLDTDEPTAKDAQCVTRLYHSSVDMTRDIASGLIG
PLLICKRKALDQKGIQNKADVEQHAAFAVFDENKSWYLEENIKAYCSNPSAVKRDDPKFY
KSNVMHT-----LN-------------------------------------G--------
--------YATDR------QNILG-FCQSETVEWHLTSVGTQDEIVPVHLAGHTFLSRGK
DRDILNLFPMSGESATVT----------MDNLGKLEIYGPKESPLHQDIDHLWK--CCKA
HPPNKELHYHIYTL---------------------------------------PFSTLKG
TQ------------------KVRREGADL-------ISL---GREFHKNHCLSFPPIPPA
----KETGPR-------------AGPP---------------------------------
----QIILNSKMIYSVS---------------------RL--AASGADI-----------
--------------------TGGGNSIHNFIDN---------------------------
-------------------LN--YRY---------RIGNLYYFTSSGTWLLSSWGSREMN
NGMRLRFRDAKCDDYEEET--EDDFDEEEVA-------VVDANVKSEQTKDKKEKENRGA
IEDDEEEEAAEEEDEEQRSLASMLGLRTFNRQIAETEE---LNLTALAMQEDT--GSITA
VSG---GGDDDDDDDDDDNKSGNLHLVVTNSS--------ACLHGDTLQETQSS----TS
VE-------------------------------SFYPKPT-------TFLDIK-MENISL
PF-----EQAQTNHEKNAIQIS------------------------GSYSQTTEPGCLRT
V------------------------EAVQRKDGAELLVS--------------TSAPIS-
--VPS---------------------SENE-----------------KEGNASGRNPSE-
-------------G---KPVLTEATLIALKEMCALLFRIKQKRNISISDNTTFNIASLAT
SPTLSTSSAFQIKTDNLSHDYDEAEEDATP------------------------------
--DPPTVSTNSTFVVEGSTEN-NS-SEQQASSEVFIAIPTAINTSRLGMLETGHLSYDYD
EAEEDANTE----------------P--PKVSTNSTFSVEESVKNNSS-KPQH-------
--------ASSEVFTAI-PTAVN---TSSF----DIVETDHFS--NEYDVYED-------
---------------------------PVLTV-----------ETSEETNDSKPHHASSE
TDLSDIQSHGNLTLDDGIN--------------------------------------SLI
STL------------------NTKTVKSWKDPS--DCP------------G-Q-------
--KCT----------------------------------------------------PKK
TEYIWNVISEK-ESYDTQAALIKDI-----------------------------------
------NNKLQNSSRNITAHPENAI-FINKKN---------KKAYKENSLPELG------
-----------QAEINNKN------KV-----L----NEQRYENSS-----SRTFIKIRR
KEKPT-----N--------------SLTPRTSKP------LAK-----------------
-------------------LGDFNDTKQSKPIVTI-GLPAE-DGDYQEYIIDDTDDEDST
S---D--SFEYQMVHYDNPYTMDSRLDTSAARNPDDIAKSYL-RSLNRLGNLRQYYIAAE
EVFWDYATRKRTEITVR-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------SGQSRTVYKKVIF-RSYQDNTFRIPRVE
GEYDEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2879)

ILGPVIRAEVDDVIKVQFKN-LASRPYSLHAHGLYYEKSSEGRSYDDESPEW
FKTDDAIMPNNTYTYVWYANKRSGPAEGQRACKTWAYYS-AVNPEKDIHSGLIGPILICQ
KGILDKYN-RPQDMREFVLLFMVFDEEKSWYFDQNR--KKSQAERRSRAL------QSHT
FPGINGVPYHLQGLRMYRGEEVHWHLLNMGGPKDIHVIHFHGQTFMEQGIE-DHQLGVYP
LLPGTFTTVEIIPSVAGTWLLETEVGEYQEAGIQAFFTVIDEGCKLPMGLASGIIQDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
SASGHID-YWEPKLARLNNTGKYNAWSTEKKE---NEHPWIQVDLKRQVILTGIQTQGAM
QILKHLYTTEYFITYSKHGRKWNVFKGDHPGTQKLFEGNSDAHGIKE-NRLDPPIVARYV
RLYPNKFYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCETAD--CSLPLGMENGAIEVS

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSYKKTWWS----SW
EPSLARLNLKG-RTNAWQAKSNNNQQWLQIDLLQSKKITGIITQGAKSMTTEMYVKTFSI
LYRDDDSTWKSYMDGS-VSAAKVFSGNVDSAGQVKNYFEPPIFSRFIRVV-----PKTWN
QSIALRIELFGCDDF---------------------------------------------
-----

------------------------------------------------------------
------------------------------------------------------------
------------ASYQDHTFPMEKMDDAVAPGQEYIYEWNITEDSGPTHDDPPCLTHIYY
SYEDLIQDFNSGLIGPLLICKKGTLTKDGVQKMFDRQHVLLFAVFDENKNWNN-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSSEGRWTISSF--ITKHF-QAG--MRAYLNI
KNCPKKTRSPKKLTRDQRRYIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANIDRKYR-------SMHLDNFSNQIGKLYKKVVYRQYQDENFTKR
MENT-NLKEDGILGPIIRAQVRDTLRIVFKNM-ASRPYSIYPHGVTLSP----YEAGVNS
SFTSGI-STVLRTVQPGETYVYKWNLLEFDEPSEQDAQCLTRPYYSDVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYLEDNIHKFCENPDEVKRDNPKFY
ESNIMSXXXXXXXX-------------------------------------X--------
--------XXXXX------XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX----------XXXXX---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTVNSSPRS
KNLRLRFRDVKCIRDY-DADSYE--IYRPPT----AT--------------PMDTRK-IH
DSTENADEE---DLDESDHLASLLGIRSFRNSSLNQEEDD-VNLTALALQDSS--ELIPP
STNIAVGSNSST-NKMTR---------------------GMSNNLTDPQTT--------V
GSPLGPHTALDKDPITS--SA---EEASPYSEDPM-----------ENHSQSIITGIQLL
PL--EAKQFKRQEHTEHKVSKAGRNSTT-----------------KHRFFWKKLLADKFE
RHVNQNNA-----------------SASRIEHWEKLPGDPLLLKQKTPSKILNGKWHLVS
EKGSYEIIQDPD--EDV-TPNKVLNSSQG--ASRPGG-EAT--LLTSKPRSHSSHRNVSG
VPRTSLPVQQD-GHRGLKKSPFSIKTRKKRREEKFVHHVLLSP-----------------
-----------------------------------------------------------R
GFHPRR-QEYATFSDRR-LGHSLLPHEPKETS-----FPMDLIQTSPSV-NLDMT

PF06049 // ENSGT00910000143988_0_Domain_5 (1796, 1804)

ATLPD
QNQHVPNDI-GQTSSPQDLHHTVSPE-----EHHPTFPTQDSEPKHSTTVSSP-------
-------RSSPPEVTQM-LEYD-LS-LESF--PTDNSQ-M-SPSLGH-ERGQTTT-----
-------------------------------------------

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

-TSSDLDQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

L

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

ATSPDLGQ
VTSSC-------------------------------------------------------
-------------------------------------S-DFGQI

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

HLSPEFDQVPLSPAQN
R----------------------

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLD-Q

ENSGT00910000143988_0_Linker_34_40 (2133, 2134)

V

PF06049 // ENSGT00910000143988_0_Domain_40 (2134, 2271)

ALP------------------------
------------------------------------------------------------
---------------------------------------------PDLGQAT--------
---------------YSDLGQM

PF06049 // ENSGT00910000143988_0_Domain_52 (2303, 2321)

TSSPD--LGQ--------

ENSGT00910000143988_0_Linker_52_55 (2321, 2323)

QA

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TPSPNIS--QTTLL----
-Y

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SFLPDF-DQM-------------HYPSEFNQS----SPLPESGQA

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FP-------YP--
-----DLDH

ENSGT00910000143988_0_Linker_60_64 (2410, 2769)

MPSP--SSPTLDETSTSSEFNPLVVV-GVSGD-NGDYVEIIPKQEV-QSSE
Y---D-YS-ETEYVTYDDPYKTDVRTDTSSSRNPDNIAAWYLLRSK--NGNRRYYYIAAE
EISWDYSKFARS---DMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTH--DIPKDTVYKKVIF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_64 (2769, 2802)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHVHGLSYDKSSEGKTYEDESPDW
FQGDNAIQPNDSYSYVWHATERAGPESPGSACRAWAYYS-AVNMEKDIHSGLIGPLLICR
KGTLHKSSNMPVDRREFVLLFMTFDEKKSWYYEKKS--KRSWRVTSSEAR------NSHE
FHAINGMIYNLPGLRMYEQEWVRLYLMNMGSSKDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTAVAENQRTGMQTPFLIIDKXXXXXXXXXXXXXXXXXX
XXXXXXX

PF00754 // ENSGT00910000143988_0_Domain_66 (3068, 3197)

-YWKSRLARLNNVGSYNAWSVEKPATDYAPRPWIQVDMQKEVVITGIQTQGAK
HYLKSYYVTEFNVAYSSDQTHWQIFKGNSAGNVMYFDGNLDASTIKQ-NHFDPPIMARYI
RISPTRSYNRPALRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEING--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3320)

QITASSFKKSWWG---NYW
EPCLARLNAQG-RVNAWQAEANNNKQWLQIDLLRIKKITAIATQGCVSLSTEMFVKSYSI
HYSDQGVSWKAYRQKS-SMVDQ--------------------------------------
------------------------------------------------------------
-----

MFPGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSTI--S

PF07732 // ENSGT00910000143988_0_Domain_0 (91, 201)

GLLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGTLTEDGTQKMFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNATMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAVTLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEE-FNLTALALENGT--EFISS
NTDIIVVSNYSSPSNISK---------------------LTVNNLEETQKTPSHQQATTA
GSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTRSPSGMRPW-----------------EDLPSDLLLLKQNNPSKILVGRWHLAS
EKGSYEIIQDTD--EHT-AVNNWLISPQN--ASRAWG-EST--PLANKPGKQSGHPKFPT
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LKHSLFLHKSNETS-----LPTDLNQTLPSM-DFDWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------RSSSPELSEM-LEYD-RS-HRSF--PTDISQ-M-SPSSEH-EVWQTITSP-DL
SQVT---------------------LSPELSQT-NLSPAFGQMPIS---------PDRSH
TTLSPDL--SHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALSQMPLSPDLSHTTLS
LDLSQTNLSPELSHRTL-------------------S--------LSPALGQMPISPDL-
-S---------------------------------------HT-----------TLSLDF
SQTN---LSPEL---------SQTNLS--PALGQMPLSPD-PSH-TTLSLDLSQPNLSPE
LSQTNL------------------SPDLSEMPIFADLSQ--IPLTPD----------L--
D----------QMTLSPDLGETDLSSD--FGQMSLSPDLSQVTLFPDIS--DTTLPPDLS
QISPPPDL-DQI-------------FYPSESSQS----LLLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ERD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTIYKKVVF-RKYLDSTFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGDSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTQAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGIENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

-----------MLFGVW---WPGLERHRVGAAQVREHYIAAESTNWRY-RPLSKGQSGSE
DSVPVFKKIAYREYEADFQKAKPTDTF--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLRAEVGDTLIVHFKNMANKPLSIH
PQGIAYSKLSEGYLYADRTSSFEKLDDAVPPGQVYKYTWEITSEIGPKEADPSCLTRVYY
SHENMVTDFNSGLIGALLVCKKGSLNEDGTQKLFDREYVLMFAVFDESKSWQK-------
---------------SASLLYTINGYANGTLPDLEACTYDNISWHLIGMSSKPEIFSIHF
NGQVLEQNHHKVSTVSIVGGASTTANMTVSQNGRWLISSL--VQKHL-QAG--MHGYLNI
EECEEKDVFKKKISFKELRMIKDWEYFIAAEEITWDYAPNVPETIDSLELRMIKDWEYFI
AAEEITWDYAPNVPETIDRHYK-------TQYLDNFSNLIGKKYKKAVFRQYTDANFNKR
LENP-RPQETG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 606)

ILGPIIRAQVRDRIKIVFKNM-ASRPYSIYLHGVTLSK----AAEGATD
PLNSTDNSTQSKAVQPGDTYTYNWSVMETDQPTAQDAQCITRLYHSAVDVTRDIASGLIG
PLLICKSEALNKRGVQNKADVEQQAVFAVFDENKSWYLEDNIKQYCSNPSSVKRDDPKFY
KSNIMHSEWQ-TGPSLAKAHEQSVMLHLFALESVDRGRKQWGSHAWLMVPTGLYSIVRNA
EPKKFFYCESNIG------TEILG-FCQDAIVQWHVSSIGSQDEIVSIRLSGHSFLTQGK
YEDVLNLFPMSGESVTVE----------MDNIGHAVKSVEPETVAF--------------
---------QIKILF---------------------------------LYQYSQFH----
-----------------------RET-----------AF---------------QT----
------------------------REPS--------------------------------
----QI------IQ--------------NLSIVTYLVLKW--LKIPVRI--LFMKP----
------------------------------------------------------------
-----------------------------------------------------------Q
SRTRVILWDAKCQKDVDDY--EDVPDLFLDF-------SSEKILKSVPE-TSPQTEEEME
ETL-DGNQEPSDDSDYQDNLASFLGLRTFRNTSMVQS-----------------------
------------------------ALPFMENS--------NTRDTGEFLETQSTLLLPTE
TE-------------------------------SLYTNYTVATRNHDETLMGQ----LV-
-------RA---------------------------------------------------
R------------------------EEAQTKDAADLLSD--------------RGTSIT-
--PSFA----------------ILSSGELQ-----------------EEDSSRGEYNVS-
-------------RKRERRDVFQTKLYAVKKMQALLSHVQQNESLSFFGNTSSEQL----
------------------------------------------------------------
-----------------------------------PLSAHAENTSSSDMLGTDQLPNKYV
EDQDVKEEEWEE-------ETSTEKTEFPKHADNVTFAEGHRAENNE-------------
------------------------------------------------------------
----------------------------------------------------LNLFGLSE
LELPKDKRDRNFTLDNASD--------------------------------------ILT
PGH------------------SSVAAKDKLGKL--IPR------------G-V-------
--KYP----------------------------------------------------SKI
MDEKWNMASVK-ENSRMETNS---------------------------------------
-----------------------------------------------------G------
-----------KLNVSHKH------PN-----LKGEERNVNGTLSK-----SVALIKTRR
RKKNDQKY-SSL-------------SMTPRG---VRLPKVQRELNCTLLSSEANHTLPLC
QANNTALSNEANHTVLLSRTNDTLTPRQFKP-IVI-GLPNG-NGDYK--------DEEIE
D---N--LYEYEYVEFDDLYMKDPRFNINNIRNPDDIAVHYL-RS---RGHMRRYYIAAE
EVIWDYAGLKKRLGKATELVSVCNAEEEVRSSQTFNESLHCFILILETFCGDKGIKDWEA
LRHYVNEAHLRTSARYLNICGWDVWGSVKRELLVNKGVSTELGALRPHCEFQLYRTPNLK
CLHFALILKKWFYFPPMEICNPSFLREIQPLRNLKCCHKKQCSHETMQNDQLLLSKIIAW
PKSSLSRRRAETVSLQQTQSLNLSTTRNSRTRRDGGNTIYKKVIF-RSYVDSTFTVREAE
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2879)

ILGPVIRAEVDDVIQVHFKN-MASRPYSLHSHGLFYEKSSEGSSYEDESPDW
FKKDDAVQPNDTYTYVWFATKRSGPIQPGPACRSWTYYS-DVNPEKDIHSGLIGPILI

ENSGT00910000143988_0_Linker_61_65 (2879, 2955)

CQ
KGTLSAIN-RPVDTREFVLLFMVFDEEKSWYFDKSS--KRTGTEKTSEQKWKPGFKIGYC
FSAINGIIYHLQGL

PF07731 // ENSGT00910000143988_0_Domain_65 (2955, 3041)

RMYKDEFVRWYLLNMGGSKDIHVVHFHGQTFTELGVP-GHRLSVYP
LLPGSFRTIEMIPSRAGVWFLDTEVGEYQQAGMQAFFIVV

ENSGT00910000143988_0_Linker_65_66 (3041, 3059)

EKECKLPMGLMNGLILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
NASHHVG-YWEPKLARLNNAGTYNAWSTDLEP---SEFPWIQVDLQRQVLITGIKTQGAK
QFPKSLYVKEFFLTYSKDKRKWITFKGNSTREQKLFEGNSDASGIKD-NHIDPPIIARYI
RVYPTVSYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEIEG--CSMPLGMENGEIKNT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSYKQSWYN----SW
VPSLARLNQQG-RVNAWQAKSNNNQQWLQIDLLKAKKITAVATQGCKSMTTEQFVKTYAI
LYSDEGTEWGTYMDDS-TCVGKVFVGNENSSGQVKHFLNPPIFSRFIRII-----PKTWN
QNIALRVELFGCDPS---------------------------------------------
-----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------G---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KNLRLRFRDVKCILDD-GEGSYEF-IFQPPE----ST--------------AITTRK-MH
DSSENSNEEFDADYDYQNRLASLFGIRSFRNSSLNQEEDE-FNLTALALENNS--EFIPP
STDTAGGSNSSSPSNISR---------------------LIANNFADHQKNISHPEATTA
GTLLGH-IGLDKNLVLNPSTA---ENSSSYSEDPI-----------EDPLQSDVTGISLL
PL--DAEGFRSQEHDKHKGFRAGRDQVV-----------------KHRFSRMEFPAHKTG
RHLSQGNT-----------------SPSRMGPRKDLPSDLLLLKQKNPSKILNGKWHLVS
EKGSYEIIQDAD--KDL-AVNKLLNSPQN--ALGTWG-ESI--PLTNKQ---GDHPKFSG
IRHKSPQVRQDGGNRGLKKSPFLIKTRKKKKEEKLAHHVPQSP-----------------
-----------------------------------------------------------R
SFHPLRGEANTTFSDKR-LDHPLLVHKSNETS----

PF06049 // ENSGT00910000143988_0_Domain_4 (1777, 1785)

-LPTDLNQTFSSM-NLSLIALLLD
HNQNPSNDT-SQTSPPPDLYQTVPQE-----EHYQMFSIRDSDQMHSTTDPSH-------
--------RSSPEPGQM-LNYD-LR-NKSF--PMDIGK-I-FPSLEL-EVWQT

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1921)

TISP-DL

ENSGT00910000143988_0_Linker_10_12 (1921, 1945)

SEPS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-FSSELSQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

SLSPDLGQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1974)

MA

PF06049 // ENSGT00910000143988_0_Domain_16 (1974, 1981)

LSPELSQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

E

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2010)

TLS--------------------PDLGQ

ENSGT00910000143988_0_Linker_17_20 (2010, 2011)

M

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

PLSPELSQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

E

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDPGQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

M

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

PLSPELSQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

E

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDPGQ

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

M

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

PLSPDLSQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

E

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSPDPGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

M

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

PLSPDLSQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

E-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DPGQMPLSP------------
----------------------------------------------------------EL
S----------------------------------------------------QE

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPD
PGQ

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

M

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

PLSPDLSQ

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

E

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TLSPDPGQ

ENSGT00910000143988_0_Linker_46_49 (2242, 2243)

M

PF06049 // ENSGT00910000143988_0_Domain_49 (2243, 2271)

PLSPEL--------------------SQMTRS-P----
----------------------------DLHQI

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2321)

PLSSDLS

ENSGT00910000143988_0_Linker_54_55 (2321, 2323)

QA

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIS--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

T

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2341)

TLPPDLR

ENSGT00910000143988_0_Linker_56_57 (2341, 2343)

QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------SSTSESSQL----LPLPEFDQIFP------

PF06049 // ENSGT00910000143988_0_Domain_60 (2396, 2410)

-YP--
-----DLGQMP-SPPPSSTLNNTFMPREFNAPVVV-GLSGD-DGDYIEIIPRQKE-ESSE
E---D-YV-EVNYVAYNDPYQTDIRTDINSFRNPDNIAAWYL-RSN--NGNRKYYYIAAE
ELSWDYAKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------DD--DVPEDTIYKKVVF-RKYLDSTFSKRDPQ
GEYEEHLGILGPVIRAEVDDVIQVNSFNILTMFILPIHVHGISFHFFMSFTSLVQLTPRY
FILFVAIKPSGTGLLFWESSLGHGPGDPGAGKREYVQFALTVFQEKDIHSGLIGPLLICQ
KGTLHKESNIPVDMREFVLLFMVFDEKKSWYYEKKP--KRSRSLTSSGAK------NSHE
FHAINGMIYNLPGLKMYEQERVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKAGWWLLCTEVGENQRTGMQTPFLIIDKECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASDYMS-YWEPKLARLNNGGSYNAWITEKLSRESDSKPWIQVDMQREVLLTGIQTQGAK
HYLKSYYTTEFYVAYSSDQTNWQIFKGNSAKNVMYFDGNSDASTIKE-NQFDPPIVARYI
RISPTRCNNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFYARLNAQG-RVNAWQAKANNNQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYAI
HYSDQGEEWKPYRQKA-SMVDKIFEGNTNIKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDTY---------------------------------------------
-----

MTLHCMRLFLLLLLGSW---WPDSGKNVVGAAKIREHYIAAQTIIWTY-KPEPEEKSRLV
HSDPVFKKISYREYEVDFKKEKPANKS--AG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLRAEVGDTLVVHFKNMADKPVSIH
PQGLVYNKKAEGSLYDDRTSSVEKQDDAVLPGQVYTYVWEITEEVGPKEADLPCLTYAYY
SHENVAMDFNSGLIGALLICRKGSLNEDGSQKLFDKEYVLMFGVFDENKSWQR-------
---------------SASLKYTINGYANGTLPDLEACAYDNISWHLIGMSSKPEIFSIHI
NGQAMEQRHHRISTVNLVGGASTTVNMTVSEEGRWLISSL--VQKHL-QAG--MHGYLTI
RDCGDKEAKKSRLSFKERRMVKNWEYFIAAE-----------------------------
---EITWDYAPNIPDSLDRHYK-------AQHLDNFSNLIGKKYKKAIFRQYTDGTFTKR
LENP-RPKETG

PF07732 // ENSGT00910000143988_0_Domain_3 (492, 566)

ILGPTIRAQLNDKVKIVFKNK-ASRPYSIYFHGVTLSK----NAEGANY
PLDPTSNDTQSKGIQPGNTYTYEWQIAKTDQPTARDAQCITRLYHSAVDIERDIASGLIG
PLLICKSEALTQKGVQKKADGEQHAMFAVFDENKSWYIEDNIKEYCSSPATVKRDDPKFY
NSNIMHT-----IN-------------------------------------G--------
--------YVSDS------SEILG-FCQDNVVQWHFSSVGTHDDIVSVRLSGHAFLYKGK
YEDVLNIFPMSGESVTVE----------MDNVETWWHKIMNHSPML--------L-ICIL
RLSMQTTQYQVHCIIPNFDSQLV-------------------------------------
------------HPNQITLVITEQSGY---VLPLGLWSFSSSKVWQPE------------
-SDLEKSGITTHVVHTFVFSDLRISRPYQLKMHSSLGNYNNSSRIA---------ATSP-
VTGLQLVADNILLS-----------SVTSASSKTYPSFKW--RSLSSNLTGLIISPKPSH
LDAQIGSLIFYVHIRNSKDQNVGSCCKHRVL-Y---------------------------
-------------------LLIIFHC---------SGAHRNPSLFAGTWLLASWGAPEKS
NGMRLRFRDARCEYEDYSS--FEVVDV---T-------YTKT--------DKKAASTSAE
ENVGEETETDDFDDDYQEELANLYSIRSSRKSKGNEET---QNLTALAWEHYE--DAAA-
SSK----------------VAGDSGLKVINT-----------NESTQLLEIHTTPLPQVE
AE-------------------------------TFQSNYTSVTTEKDLFLASTSDGKPDL
VF-----ENRSQ----------------------------------SSYA----------
I------------------------DHSNMSAAEHLLSN--------------GEAQME-
--VAEEPLTNGK--------DSKFSSEEHQ-----------------TESTGKGNDSIN-
-------------SKRKKRSSLATKFYSIQKMNALLNHVR-NKNASFSDKTSA-------
------------------------------------------------------------
---PH-------------------------------SMHHAENTTNITPVGDGQLPSDYD
DELEEEEMK----------------EENAMQAVNVTLELDVFVEGDES-NAS--------
------------------------------------------------------------
--------------------------------------------------------SLSE
LELSKDKQADTFSLDHTLG--------------------------------------NVR
PNS------------------SPALVKNLLEAS--LPR------------T-V-------
--KYS----------------------------------------------------SKM
TNEEWNLVSAK-ESLRLEANLDKSV-----------------------------------
------SGKFHRGGRNG------TL-FLNK-H---------MKKDDGFSGLMGG------
-----------KRKGSYRH------PT-----LKGKRGNKNDTLSS-----SGALIRIRR
KKQEYPKT-AH--------------LLSPRSKKSQKFPKPAAGFGRALFQIEANHTAPLC
CTN---TTEAPSEASHGGLPNHTLSPRQFKPSIVI-GLPHG-NGDYE-YFSGEYYAEDTS
G---G--EYEYHYVSFDDPYMTDPKLNIKEQRNPESIAEHYL-RS---RGNERRYYIAAK
EVCWNYAGFKKREIRSTMN-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------DKACKDGATYKVVF-QRYTDSTFTTLQDE
GEYEEHLGILGPVIRAEVDDVILVHFKN-LASRPYSLHAHGLFYEKSSEGSTYDDESTTW
FKEDDKVQPNSSYIYVWYANRRSGPLQSGAACRSWVYYS-DVNLEKDTHSGLIGPILICQ
KGTLSMSDNKRTSTRDFFLLFMVFDEEKSWYFDKRS--RRSCTEKTQGNQ------QCHK
FYAIN

PF07731 // ENSGT00910000143988_0_Domain_65 (2946, 3043)

GITYSLQGLKMYEGELVRWHLLNMGGPKDIHVVHFHGQTFVEQGEP-KYQLGTYT
LLPGSFQTIEMKPQRPGWWLLDTEVGEYQQAGMQASYLVLEK

ENSGT00910000143988_0_Linker_65_66 (3043, 3059)

ECRIPMGLASGLILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
NASDHLD-YWEPKLARLNNSGTYNAWSTTM-K---DDLPWIQVDFQRQVLLTGIQMQGAK
QFLKSLYIQKFFIAYSKDKRKWKTFKGDSFQAQKIFEGNSDANSIKE-NIIDPPIIAKYI
RVYPTQAYNRPTLRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVDG--CSLPLGMENGAIKNS

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSVKTSWFN----TW
DPFLARLNQKG-KINAWRAKSNNNQQWLQIDLLSIKKITAVATQGVKSMSSENFVKTYVI
LYSNEGSEWKSYTDGS-SSVAKVFSGNENSDGHVKHFFNPPILSRFIRIV-----PKTWY
HGIALRVELFGCDFD---------------------------------------------
-----

MSPGRAHLWVLLALGAS---LAGWGVRAGPAGVLRQFYVAAQKISWTY-RPDPPDP-SLN
SFTPSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVHFKNKADKPVSIH
PQGIKYSKFSEGASYSDHTSPVERMDDAVAPGQEYTYEWVISEDSGPTQDDPPCLTHIYY
SYKNLTKDFNSGLVGPLLICKKGTLTEDGTQMMFDKQFVLLFAVFDESKSWDP-------
---------------SPSLMYTVNGYVNRTMPAITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHQKVSTVTLVSATSTTANMTVSPEGKWTISSL--IPRHF-QAG--MQVHIDI
VNCPKKTRNVKKLTLEQRRYIKRWEYFIAAE-----------------------------
---EVMWDYAPIIPASMDKIYK-------SLHLDNFSNRIGKHYKKVVYRQYQDESFTKR
MDNR-NINENGILGPIIRAQVRDTLKIVFKNT-ASRPYSIYPHGVTFSP----YEEEVNS
SSTSGN-HTMIRAVQPGEIYTYKWNILESDEPTDSDAQCLTRPYYSDVDITRDIASGLIG
LLLICKSRSLDMRAY-RAADIEQLAVFAVFDENKSWYIEDNINKFCENPEMVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------FVPGS------ITTLG-FCYDDTVQWHFCSVGSQDDILTIHFTGHSFIYGKR
HEDTLALFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLMTMNSSPRN
KNLWLRFRDVKCIGDD-DEDSYK--IYAPPE----VS-------------TPMDVRK-IK
FPSENEHEEINPDDDYQDDLASALGLRSFRNSSLNQNEDE-FNLTALALENSS--ELISP
STDVAIGSNSSF----AR---------------------TVVNNITEPQKTLPHVEASIA
VHLLEHFSGSDENPVVNSSTK---EYSSPYSEDQI-----------EEPEQSDVTEISLL
----GAKRFRDREHATHKAARKNRNQLR-----------------KHRLSWMKLPAHKTQ
RHSNQDNT------------------SSRMGTWEDLPSALLLLKQKNPSRILDEQWHVVS
EKGSYEIIQDND--EDM-AVTELLNSPQN--VSRTLK-ENN--QPENKPGEHSDHSKYSG
FRPRSLHVRQGGENGELKKIPVFIKTRKKKKEPKIAHHIPFSP-----------------
-----------------------------------------------------------V
DIHSLKRAHYTRFSDKR-LKHSLLLHKLSKTS-----LPIDLNQTLPSI-SPVQIDSLPV
HNLSLTSNT-GQTNIPPDLSQTVAPG-----EYNQTSLIQDPVQMHSTTDRSH-------
-------RSSPTGLSQI-VSYD-LN-HELH--PVDTGPLL-SHAQEH-EAWQMTIFS-GL
K-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
G----------KTKLSPNISQMTSSQE--HNQVTHSPGLSQEALSPNAT--ETTHLSNIG
QTSYPSDL-NQT-------------SYPSESNQL----LTLSEFNQTSP-------YP--
-----DLGHIPPSPLPSPSLNDTFISNEFNPVVIV-GLSRD-DEDYIELVPRQEV-QIPE
E---D-YA-EVDYVTYDDPYQTDGRTDINSSRNPDDIAAWYL-RSN--KGNRKYYYIAAE
EISWDYAEFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEASD--DVKKDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVHFKN-LASRPYSIHAHGLSYEKSSEGRSYDDDSPEW
FQDDNAILPNNSYTYVWHATDRSGPETSGSACRAWAYYS-AVNPEKDIHSGLIGPILICR
KGTLHMQSNMPVDMREFVLLFMVFDEKKSWYYGKS---KRTWRLESSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLSGSFKTLEMKASKPGWWLLDTEIGENQIAGMQTAFLIIDKDCKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3196)

QI
KASEHLG-YWEPKLARLNNTGSYNAWSVENSRLKTGSKPWIQVDMQKEVIVTGIQTQGAK
HYLKSLYTTEFYVAYSSDRSSWQIFKGNSTQNVMYFDGNSDASTIKE-NEFDPPIVARYI
RITPTGFYNRPTLRL

ENSGT00910000143988_0_Linker_66_68 (3196, 3222)

ELQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNQQWLQVDLLKIKKVTGIVTQGCKSLSSEMYVKSYTI
YYSDQGVEWKSYREKS-FMVDKVFEGNSNVNGHMKNFFNPPIIARFIRII-----PKTWN
QSIALRLELYGCDIY---------------------------------------------
-----

MFPGCPRVWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNA-SLN
HSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIKYSKLSEGASYLDHTFPVEKMDDAVAPGQEYTYEWSISKDSGPTQDDPPCLTHIYY
SHENLIEDFNSGLVGPLLICKEGTLTEDGTQKMFDKQLVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYANGTMPDITVCAYEHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWIISSL--IPKHL-QAG--MQAYIDI
KNCPKKTRRLKKITREQRRQIKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLDNFSNRIGKHYKKVIYTQYEDESFTKH
IENP-HMKEDGILGPIIRAQVRDTLKIVFRNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGS-NTMIRAVQPGETYTYKWNILELDEPTENDAQCLTRPYYSNVDIMRDIASGLIG
LLLICKTRSLDKRGIQRAADIEQRAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPNFY
ESNVMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFEDTVQWHFCSVGTQNDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWILTTMNSNPRS
KKLRLKFRDVKCIRDD-YEDSYEIEIYEPPE-----S-------------SVIVTRK-MH
DPSENEDEESDADYDYQNRLASALGIRSLRNSSLNQKEEE-FNLTALALENNS--EFISP
NTDITVGSNYSSPTNISK---------------------LTVSNLAEPQKTPSHQQATIA
GSPQRHL--IGKNSVFHSSRA---EHSSPYSENPI-----------EDPLQSDVTRIHLL
SL--GAGEFRSQEHPKHKEPKVKRDQAA-----------------KHRFSWMKSPTDKIG
RHLSQDNG-----------------SSSRMRPRKDLPSDLLLLKQKNPSKILVGKWHLAS
EKGSYEVIQDTD--EDT-AVNNQLISPQN--ASRAWG-EST--PLTNKPGKPSGHPEFPR
VRHKILQVRQDGGNSGLKRSQFLIKTRKKRK-EKHTHHAHLSP-----------------
-----------------------------------------------------------R
AFHSLRSEAYNIFSERR-FNHSLWLHKSNKTS-----LPIDLNETLPSV-DFGWIPSLPD
HNQNSSNDT-GQTS-SPDLYQSVPPE-----ERYETFPIQDPDQMNSTSDPSH-------
-------RSSFSEFSEM-LDYD-QN-HKSF--PTDISQ-M-SLSSEH-EVWQTI

PF06049 // ENSGT00910000143988_0_Domain_10 (1915, 1923)

TSP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPELSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

LSPELGQ

ENSGT00910000143988_0_Linker_13_15 (1963, 1964)

I

PF06049 // ENSGT00910000143988_0_Domain_15 (1964, 1981)

SLSP---------DLGQ

ENSGT00910000143988_0_Linker_15_17 (1981, 1983)

MA

PF06049 // ENSGT00910000143988_0_Domain_17 (1983, 2001)

LSPDL-----------SQ

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

V

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TLSPELSQ

ENSGT00910000143988_0_Linker_18_20 (2010, 2012)

TN

PF06049 // ENSGT00910000143988_0_Domain_20 (2012, 2019)

LSPELGQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

I

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

PLSPDLSQ

ENSGT00910000143988_0_Linker_21_25 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2029, 2084)

TV----------
------------------------------------SP-ELSQTNLSPELGQIPLSPDLSEMTLSPELSQT-SLSPDLSQVT--LSPELS-QTNLSPE-LGQI-----------SLSPDLSQMA---LSPDLSQVTLSPDLSQTNLS--PELGQIPLSPD-ISQ-TTVSPDISQTTLSPELSQTNLSPD----------------L---------KLSE--MPLFGDLSQIPLS-PDL--D----------QMMLSPDLGETDLFPD--FGQISLSPDFTQVTLSPDLS--ETILLPDLRQISPPPDL-NQI-------------FYPSESSQS----LLIPEFNETFP-------YS-------DIGRTP-SP-SSPTLNDTFLLKEFNPLVIV-GLSKD-GTDYIEIIPREEV-QSSED---D-YT-ETDYVSYDDPYKTDVRTNINASRNPDNIAAWYL-RSN--NGNRRNYYIAAEEISWDYSEFVQR---ERD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEDID--NTPENTIYKKVVF-RKYLDSSFTKRDPQGEYEEHLGILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPAWFQDDNAVQPNSSYTYVWHATERSGPESPGSACRAWTYYS-AVNPEKDIHSGLIGPLLICQKGILHKESNMPVDMREFVLLFMIFDEKKSWYYEKKS--RMSWRLTATEVK------NSHEFPAINGRIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRECKMPMGLSTGIISDSQIKASEFLG-YWEPRLARLNNGGSYNAWSIEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYIRISPTQAYNRPTLRLELQGCEVNG--CSTPLGMESGKIENKQIMASSFKKSWWG---DYWEPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIITQGCKSLSSEMYVKSYSIHYSDQGVEWKPYRLKS-SMVDKIFDGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWNQSIALRLELF

PF06049 // ENSGT00910000143988_0_Domain_27 (2029, 2084)

TV----------------------------------------------SP-ELSQ

ENSGT00910000143988_0_Linker_27_26 (2084, 2086)

TN

PF06049 // ENSGT00910000143988_0_Domain_26 (2086, 2093)

LSPELGQ

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

I

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

PLSPDLS
E

ENSGT00910000143988_0_Linker_29_31 (2102, 2103)

M

PF06049 // ENSGT00910000143988_0_Domain_31 (2103, 2111)

TLSPELSQ

ENSGT00910000143988_0_Linker_31_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

SLSPDLSQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

VT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPELS-Q

ENSGT00910000143988_0_Linker_34_32 (2133, 2135)

TN

PF06049 // ENSGT00910000143988_0_Domain_32 (2135, 2143)

LSPE-LGQ

ENSGT00910000143988_0_Linker_32_36 (2143, 2155)

I-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

SLSPDL
SQ

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

MA---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSQ

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

V

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQ

ENSGT00910000143988_0_Linker_38_39 (2184, 2186)

TN

PF06049 // ENSGT00910000143988_0_Domain_39 (2186, 2195)

LS--PELGQ

ENSGT00910000143988_0_Linker_39_40 (2195, 2196)

I

PF06049 // ENSGT00910000143988_0_Domain_40 (2196, 2206)

PLSPD-ISQ-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TVSPDISQ

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TLSPE
LSQTNLSPD----------------L---------KLSE--MPLFGDLSQIPLS-PDL--
D----------QMM

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPDLGE

ENSGT00910000143988_0_Linker_51_52 (2302, 2304)

TD

PF06049 // ENSGT00910000143988_0_Domain_52 (2304, 2313)

LFPD--FGQ

ENSGT00910000143988_0_Linker_52_54 (2313, 2314)

I

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

SLSPDFTQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDLS--ETILLPDLR
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-NQI-------------FYPSESSQS----LLIPEFNETFP-------YS--
-----DIGRTP-SP-SSPTLNDTFLLKEFNPLVIV-GLSKD-GTDYIEIIPREEV-QSSE
D---D-YT-ETDYVSYDDPYKTDVRTNINASRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ERD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDID--NTPENTIYKKVVF-RKYLDSSFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPAW
FQDDNAVQPNSSYTYVWHATERSGPESPGSACRAWTYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKESNMPVDMREFVLLFMIFDEKKSWYYEKKS--RMSWRLTATEVK------NSHE
FPAINGRIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSIEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTQAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3223)

LQGCEVNG--CSTPLGMESGKIENKQ

PF00754 // ENSGT00910000143988_0_Domain_68 (3223, 3369)

IMASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIITQGCKSLSSEMYVKSYSI
HYSDQGVEWKPYRLKS-SMVDKIFDGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
TFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCITDD-DEDSYE--IFEPPE-----S-------------TVIATRK-MH
DPLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNISK---------------------LTVNNFAEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDSI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKRKGPKVERDQAA-----------------KHRFSRMKLLAHKVG
RHLSRDTG-----------------SRSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPGKQSGHPRFPR
VRHKSLQVRQDGGKSGLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRTEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-RQTSSLPDLYQTVPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------RSSAPELREM-LEYD-RS-HKSF--PTDISQ-M-SPSSER-EVWQTVPSA-DL
SQVT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPQLSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALGQ
MPMSPDL--SHT

PF06049 // ENSGT00910000143988_0_Domain_17 (1993, 2001)

TLSPDLSH

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

T

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

TLSPDLSH

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

T

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2017)

TLSPDL

ENSGT00910000143988_0_Linker_20_21 (2017, 2020)

SPT

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLSH

ENSGT00910000143988_0_Linker_21_27 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2029, 2111)

TL----------
------------------------------------------------------------
----SPDLSH

ENSGT00910000143988_0_Linker_27_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2119)

TLSPDL

ENSGT00910000143988_0_Linker_33_34 (2119, 2124)

SPTT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLS-H

ENSGT00910000143988_0_Linker_34_32 (2133, 2134)

T

PF06049 // ENSGT00910000143988_0_Domain_32 (2134, 2141)

ILSPD-L

ENSGT00910000143988_0_Linker_32_36 (2141, 2155)

SPT-----------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SH

ENSGT00910000143988_0_Linker_36_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

LSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLSQTNLS--PALGQMPM

PF06049 // ENSGT00910000143988_0_Domain_40 (2198, 2206)

SPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2217)

TN

PF06049 // ENSGT00910000143988_0_Domain_43 (2217, 2224)

LSPD
LSHTTL-----------------------------------------------S-PDL--
S----------QTN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSHTNLSPA--LGQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

V

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TVSPDIS--ETTLLPDLS
QI

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDL-DQT-------------FYPSESSQL----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSEFVHR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVVITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIGNK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MSPGHACLWVLLALGAG---LAGWGVRAGLVRGLRQFYVAAQSVTWTY-RPEPPDP-SLN
PFTPSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDLMKVHFKNKADKPISIH
PQGIKYNKFSEGASYSDHTSPLERMDDAVAPGQEYTYEWFISEDSGPTQDDPPCLTHIYY
SYENLTEDFNSGLIGPLLICKKDTLTEDGTQKMFDKQHVLLFAVFDESKGWNP-------
---------------SPSLMYTVNGYVNQTMPALTVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKVSAVTLVSATATTANMTVSPEGKWTISSL--IPRQF-QAG--MQAHIDI
INCPKKTRTTTKLTREQRRYIKRWEYFIAAE-----------------------------
---EMMWDYAPIIPTTMDKLYR-------SLHLDNFSNQIGKMYKKVVYRQYQDEGFTKR
MDNT-KMNENGILGPIIRAQVRDTLKIVFKNS-ASRPYSIYPHGVTFSP----YEDEVNS
SSTSGN-HTMIRAVQPGETYTYKWNILESDEPTDSDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQQVVFAVFDENKSWYIEDNINKFCENPDMVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTVHFTGHSFIYEKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRN
KGLQLRFRDVKCMRDD-DEDSYE--IYEPLS-----P-------------TAMAVRK-IH
SPSENEDEETDPDDDYQDILASSLGIRSFRNSSLDHKEDE-FNLTALALENSS--ELISP
STNVSIGSSSSS----SR---------------------TTVSNHTEPQKTLPHAGASTT
GHLLEHLSGLDKNPVVNSSTE---EYSSPYYEDQI-----------EDPLQSDVTEISLL
----GAKGFRDGEYAKHKAYRTKRNQLA-----------------NHGFFWMILPAHKTG
RHSNQDDT------------------SSRMGPLEDLQSDLLLLKQKNPSKILDGKWHVVS
EKGGYEIIQDID--KDL-AINELLNSPQN--VSKIWR-ERI--PPENNPGKQNDHPKFSG
VRHKSLQVRQHGENSGLKKRPFLIRTRKKKKEPKLAHHTPLSL-----------------
-----------------------------------------------------------R
GIYPLKGADYTTFSDRR-LNHSVLLHKSNETS-----LPIDFNQTSPSI-NLVQIGSLPD
HNLRPPNDT-GQTSSPPDLYQTVPPE-----ERYQTSPTQDPDQMHSTTDPSH-------
-------RSSPPELSQM-FNYD-LS-HELH--PVDIG----------------------L
SQPS---------------------SSSSQGQTT----------PSSDLRQMITSPDLGR
IPLSSDFSQ---MPSPDLGQMPLSPELGEA------------------------------
----------------------------------NPSP-DLSQKTPSPEFSQMPLSPELG
ETS---------------------LSPHFN-LGQMPLS-PELG----------EASPSPD
FSQM---PSPDLGQMPLSPELGEASPS--PDFSQM-PSPD-LGQ-MPLFPELSEANLSPN
LSQKTPAPDLS---------QIPLSPEFGEANLSPDLSQ--KTPALDLSQIPLS-PE--S
G----------EAKFSPNVSQMTPSQD--LNKIPYSPGLSQVTLSPDIS--EKTLPPNFK
QTSHPSDL-DQI-------------SYPSES-----------------------------
-----NLVHMP-SPLPSPTLNDTFISNEFNSLVVV-GISGD-DGDYIEIIPQQEV-QISE
E---D-YA-EIDYVAYDDPYQTDRRTDINSSRNPDNIAAWYL-RSN--KGNRKYYYIAAE
EIFWDYAEFAQS---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SEDGD--DIRKDTTYKKVIF-RKYLDSTFTKRDPR
GEYEQHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLAYEKSSEGKTYEDDSPEW
FKDDNAVQPNRSYTYVWHATDRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGTLHKQSNIPVDMREFVLLFMVFDEKKSWYYGKS---ERTWKLESSEVK------NSHE
FHAINGKIYNLPGLRMYEQEWT----------------------LLENGSQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLR-YWEPKLARLNNGGSYNAWSVAKSALETSSKPWIQVDMQKEVIVTGIQTQGAK
HYLKSCYTTEFHVAYSSDRTSWQIFKGNSTKNIMYFEGNSDASTIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMEDGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRQKS-SMMDKIFEGNGNVKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELYGCNIY---------------------------------------------
-----

MFPGCPQVWVLVVLGTS---WVGWGSQGTEAAQLRHFYVAAQGISWSY-RPEPTNA-SLN
HSATSFKKIVYREYEPYFKKEKPRSSI--SELILAIPRFEGGESAV----------L-RN
CPHVLMAPTSPGASYLDHTFPVEKMDDAVAPGQEYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLVGPLLICKEGTLTEDGTQKMFDKQLVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYANGTMPDITVCAYEHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSPEGKWIISSL--TPKHL-QAG--MQAHIDI
KNCPKKTRRLKKITREQRRHIKRWEYFIAAE-----------------------------
---EIIWDYAPVIPANMDKKYR-------SLHLDNFSNRIGKHYKKVMYTQYEDESFTKH
IENP-HMKEDGILGPIIRAQVRDTLKIVFRNM-ASRPYGIYPHGVTFSP----YEDEVNS
SFTPGS-NTMIRAVQPGETYTYKWNILELDEPTENDAQCLTRPYYSNVDIMRDIASGLIG
LLLICKTRSLDKRGIQRAADIEQRAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNVMSNFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQNDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWILTTMNSSPRS
KKLRLKFRDVKCIRDD-YEDSYE--IYEPPE-----S-------------SVIATRK-MH
DPSANEDEESDADYDYQNRLASALGIRSLRNSSLNQKEEE-FNLTALALENAS--EFISP
NTDRTVGSNYSSPANISK---------------------FTVDNLAEPQKTPSHQQATIA
GSPQRHL--IGKNPVFHSSTA---EHSSPYSENPI-----------EDPVQSDVTGIHLL
SL--GAGEFRSQEHPKHKEPKIKRDQAA-----------------KHRFSWMKSPADKIG
RHLSQDNG-----------------SSSRMRPRKDLPSDLLLLKQKNPSKILVGKWHLAS
EKGSYEVIQDTD--EDT-AVNNQLISPQN--ASRAWG-EST--PLTNKPGKPSGHLEFPR
VRHKILQVRQDGGNSRLKKSQFLIKTRKKRK-EKHTHLGPLSP-----------------
-----------------------------------------------------------R
TFHSLRSEAYDTFSERR-FNHSLLHHKSNKTS-----LPIDLNQTSPSV-DFGWIPSLPD
HNQNSSNDT-GQTSSPPDLYQPVPPE-----EHYETFPIQDPDQMNSTSDPSH-------
-------RSSSPELSEM-LDYD-QN-HKSF--PTDISQ-M-SASSEH-EVWQTITPP-DL
SHVT---------------------LSPELNLS---------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------HM-----------NLSSDL
SQT---------------------------------------------------------
------KLS----------------P---------ELSE--MPLFVDLSQIPLS-PDL--
D----------QMMLSPDLGETDLSSD--FGQISLSPDLTQVTLSPDLS--ETILLPDLR
QISPPPDL-NQI-------------FYPSESSQS----LLIPEFNETFP-------YS--
-----DLGRTP-SP-SSPTLNDTFLLKKFNPLVIV-GLSKD-GADYIEIIPREEV-QSSE
D---D-YT-ETDYVSYDDPYKTDVRTNVNASRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ERD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDID--NTPENTIYKKVVF-RKYLDSSFTKRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPAW
FQDDNAVQPNSSYTYVWHATERSGPESPGSACRAWTYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKESNMPVDMREFVLLFMIFDEKKSWYYEKKS--RMSWRLTATEVK------NSHE
FPAINGRIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYV
RISPTRAYNRPTLRLELQGCEVNG--CSTPLGMESGKIENKQITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKVKYNYAWLRRK-----DYLSLGVQGCNFYI-----SIYTV
I-----------KDFL-IFCFQIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MLPVCRRLCILVVLGTS---WAGWGSHPAEAARVRQFYVAAQGILWNY-HPEHTDP-SLN
S-KPSFKKIVYREYEPHFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTMKVHFKNKADKPISIH
PQGIKYSKFSEGASYPDHTFPAERMDDAVAPGGEYTYEWVISEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTVNGFVNRTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTITLVSATSTTANMTVSPEGRWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPASMDKKYR-------SLHLDNFSNQIGKQYKKVIYRQYEEETFTKR
TENS-NIKQSGILGPIIRAQVRDTLKIVFRNM-ASRPYSIYPHGVTFSP----YEDEGNS
SSTPGS-HTMIRPVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDLASGLIG
LLLICKSRSLDQRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTYDDVLTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNIG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRL
KNLRVRFRDVKCIRNDDDEDSYE--IYEPSA----PT--------------SMTTRK-IH
DSSEYDFGINNDDYDYQFSLATQLGIRSFRNASLNQEEDE-FNLTALALENSS--EFIFP
NTDRVNDSKS--SRNLSG---------------------ITGNNLKESQRTPPGSGSTVT
GTLLKDLAGLDENSVLNPATE---HHSSSYYESDV-----------GDS-QSDITVIHLL
PL--GTKGSGSQEHAKHKKAKSERPNLM-----------------KHRFPHMKVPARKTG
RHSNPKNT------------------YSRVKSREEIPIELFLLKQKNTSKFLDREWYLAS
EKGSYEIIPAND--EDT-AVEKLPNSPQNQNISKSWG-DST--SPTKTAGKPSDIPVFSR
VRNKFPQVREEERNSSLMK----IRTRKKKKNKRLSLHSPLSP-----------------
-----------------------------------------------------------R
GFHPLKGDAQLTFLDQR-LNHSLLPHKPNESA-----PAIDLNQTSSST-SIDR--SLPD
HNQTLPHDT-GQKSSAFNLYQSVPPE-----EHSPTFPVQDPDQTHSATDLSH-------
-------RSSLPQPSQE-LDYD-LS-HESY--PEDISQ--------------ASFFP-DQ
SQKS----------------------LSSEDGQTSPSSDLSLFTVSPELDQTTISPDLGQ
VPLSPGDNQ--MTSPQDLGQVPLSPEDNQM------------------------------
------------------------------------------------------------
--TSPQDLGQV-SLSPGDNQMI--SSQDLG-QVPL-------------------------
------------------------------------------------------------
------SSNNTQKSSPQDLSLLTLP---------PEFDE--VALPQDLDELPLS-SDF--
S----------QVTLSPDLSPLTLSPD--FDEIIISSDLGQVTLSPDLI--QTSPTLNHR
HKTASSDP-GQA-------------SHPSDSGQS----SPLPELNQTLP-------DL--
-----SHVPSEPSPLPSPTLNNTSVSEEFNPLVVV-GLSRV-DGDDIEITPNEEL-ESIA
D---DDYAEDEDYVTYSDPYKTDTRTNINSSRNPDNIAAWYL-RGH--GGNKQYYFIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDTD--ATPKDTTYKKVVF-RKYLDSTFTRRDPQ
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAVQPNSSYTYVWHATERSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHPKSKLPMDMREFVLLFMAFDEKKSWYYEKF---KRSWRIESPEVK------NSHK
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSQDIHVVHFHGQTLLDNSTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQIAGMQTPFLIIDKGCKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASGHLN-YWEPKLARLNNGGSYNAWSIEKSALDFAFQSWIQVDMQKEVVVTGIQTQGAK
HYLKSCFITEFNVAYSSDQTNWQIFRGNSTKNTMDFAGNSDASTIKE-NQFDPPIVARYI
RIHPIKSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSMPLGLEDGRIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
DPSRARLNAQG-RVNAWQAKANNNKQWLQVDLLRIKKITAIVTQGCKSLSSEMFVKSYSI
QYSDQGVEWKPYRQKS-SMVDKVFEGNSNTKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFAGCPPLWALLVLGPS---WAGWGSPGAEAAQLRQFYVAAEHVRWSY-RPEPTNL-SLN
AFATSFKKIVYREYEAYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKIHFKNKADKPLSIH
PQGIRYSKFSEGASYPDHTFPVEKMDDAVAPGQEYTYEWTISEDSGPTHDDPPCLTHIYY
SHENLVQDFNSGLIGPLLICKKGTLSEDGTQKMFEKQLVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHVSWHLIGMSSGPEMFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSTEGKWIISSL--TPKHL-QAG--MQAYINI
KNCPKKTRMPKKMTREQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIVPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYEDESFTKR
EENP-NIKEDGILGPVIRAQVRDTLKITFKKYGASRPTGILPSWSASPP----IKTEVN-
-------------------------------SSSTSRQEAVKPGETDVDIMRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMSSKFEHSIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYEKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRS
KNLRLRFRDVKCILDD-DEDSYE--IYEPPS-----S-------------TAMATRK-IH
DFPESNDDENDTDDYYQYILASELGIRSLRNSSLNQEEDK-FNLTALAMENSS--EFISS
STDTTVGSNSSPPRNVSS---------------------LIVNNLTGPQKTLPHPGATTA
GHPLEHFNGLDENSVLNSSMA---EHSSPYSEDPR-----------EDAPQSDVTGISLL
PH--GAGGFRRKEHAKHKGRKAGRDQAA-----------------KHRFSQMKLLAHKIG
RHFSQDNGSPSGM-----------------GPWEDLPSDLLLLKEKNPSKILNGKWHLAS
EKGNYEIIQDTE--EDM-AINKPLTGPQN--DSSTWGSEST--PLINKPGNQSSLPKFSR
VKHKYLHVRQDGRNSGLRKSPFLIRTRKKKKAEKLGYYVPLSP-----------------
-----------------------------------------------------------R
GFHPLRGEASATFSDQT-LNHSLLLRKSNETS-----LPTDLNQTLPSM-NIDLMASLPD
HNQNPPNDT-SETSSPPDLYQTVPPE-----EHYQTSPMQDPDQTHSTTDPSH-------
-------RSSPPELSWM-PNYD-LN-HQSF--PADIGQ-L-SPYLEH-EVWKTTISP-DL
NLAT---------------------ISPDPSQS-SLSPDLGT--ISPDFSQWSLSPDLGT
I-------------SPDLSQSSFLPRPG--TWVPSLQTSPIILLQTWLPSLQTSSHSSFS
PDLDLATI----------------------------SP-DLSQSFLSPDL---------A
TISPDLNLSQS-SLSADLG--I--ISPDLS-QSSLSAD-LDLSQ-------SSLSPDLDL
SQSS---LSPALDQMTLSTELTQTSLS--LGISQMPLSPD-LSH-TTL------------
---------------------------------SPDLSQ--TTPSPVLGQMSLS-PDL--
S----------QMTLSPDPSETNVSPD--FDQIPLSSALGRVALSPDIS--QTTLPPDLS
QTSPPPDL-DHT-------------FYPSESSQS----LPLPELSETFP-------YS--
-----DPGQMP-S----PTLNDTFISKEFNPLIVV-GLSRD-NGDYIEIIPRLED-QGSD
E---D-YV-EVDYVAYSDPYQTDVRTDINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDID--DIPEGTIYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYDKSSEGKAYEDDSPEW
FKKDNAIPPNSSYTYVWHATDRSGPESPGSACRAWAYYS-AVDPEKDIHSGLIGPLLICQ
KGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKKS--KGSWRLPSSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRFHLLNMGGSQDIHVVHFHGQTLLENGHQQH-QLGVWP
LLPGAFKTLEMKPSKPGWWLLNTEVGENQRAGMQTPFLVIDKECKMPMGLSTGIISDT

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLG-YWEPKLARLNNVGSYNAWSVEKLATEFGSNPWIQVDMQKEVVITGIQTQGAK
HYLKSLYTTEFNVAYSSDHTNWQIFKGNSTRNVMYFNGNSDASSIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAMITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRQKS-SMVDKIFEGNSNTKGHVKNIFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPRCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--LG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHM-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EIIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRSYSIYPHGVTFSP----HEDEVNS
SFTSGRNNTMIRAVQPGEIYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTFSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DDDSYE--IFEPPE-----S-------------TVIATRK-IH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNTSK---------------------LTVNNLTEPQKTPSHRQATTA
GSPLRHL--TGKNSVLNSSTA---EHSSPYSEDSI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHTKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTD-----------------SPSRVRPWEDLPSDLLLLKQNNSSKILVGRWHLAS
EKGSYEIIQDTD--EDT-VVNNRLISPQN--ASRDWG-EST--PLANRPEKQRGHSKFPR
DRHKYLQVRQDGGKSRLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEVYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTVPPE-----EHYEMFPIQDPDEMHSTSDPSH-------
-------RSSSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTVTSP-DL
SQVT---------------------LSPELIQT-NFSPDLSHMTLSPELSQTNLSPALGQ
MPMSPDL--SHTTLSQDLSHTTLSLDLSQTNLSPE-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------DL--
S----------QTNLSPELSQTNLSPA--LGQMPLSPDLSQVTVSPDIS--ETTLLPDLS
QISPPLDL-DQI-------------FYPSESSQS----LHLPEFNETFP-------YL--
-----DLGQLP-SP-SSPTLNDTFLSKEFNPRVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEQHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGAFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELYGCDVY---------------------------------------------
-----

MFPGCPRLWILVVLGSS---WAGSGSPRAEAARLRQFYVAAQGISWNY-RPEPTNQ-SLD
PFATSFKKIVYREYEAYFQKEKPRSRT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDTMRVHFKNKAGKPLSIH
PQGVTYSKASEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXTLTEDGIQKMFDKQHVLMFAVFDESKSWSR-------
---------------SPSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSATSTTANMTVSPEGKWTISSL--IPKHF-QAG--MQAYIDI
KNCAKKTRNLKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPATMDXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXXXXIVFKNM-ASRVYSIYPHGVTFSP----FEDEVNS
SFSSGS-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDTASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNIHKFCENPDKVNRDDPKFY
ESNLMSNFTLSAIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRS
KNLRLRFRDVKCIRND-DEDLYE--IYEPSA----ST--------------AMTTRK-MR
NSSEIRDNGDDAEYDYQDILALSLGIRSFRNSSLNQEEDE-LNLTALALENSS--EFIPP
NTDTAIGSNSSSPHNVSR---------------------LTANNIAEPHMTPPHPEATTA
GPHVGH-INLEKNSVLNLSTE---ELSSPYSEDPI-----------EDPLQSNVTEISLL
PP--GAEGFRSQEHAKHERFKVGREQAA-----------------KHRSSPLEFPAHVTG
RHLSQGNS-----------------SPPRMGPWAP-PSGLLLLKQKTPSRILNGKWHLVS
EKGSYEIIQEAD--GDV-AGNEVPSGPWN--ASRAWG-EGT--PLTDKPGHRGGHPKSSR
FRYKFPQVRQDGGNSGLKNGTFFIRTRKKKKEEKLAHYVPFSP-----------------
-----------------------------------------------------------R
GFRPLRGEANVTFR---------LLHESSETP-----FPTNHNHTLPSA-NLSLAASLPD
HNQNPANDT-NHTSSPPDSYQMMPPE-----EHHQTFPIRDSDHVRFTTDPSH-------
--------RSSPGPGQT-LDYG-LR-NESF--PSDMGK-M-PPSLEL-EVWQT

PF06049 // ENSGT00910000143988_0_Domain_10 (1914, 1923)

TMSP-DL
SH

ENSGT00910000143988_0_Linker_10_12 (1923, 1945)

PS--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LSPELHQ----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDLGQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

E

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

TLSPDLTQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

M

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

TRFP-----------DLGQ

ENSGT00910000143988_0_Linker_17_18 (2001, 2002)

L

PF06049 // ENSGT00910000143988_0_Domain_18 (2002, 2010)

PLSPDLGQ

ENSGT00910000143988_0_Linker_18_20 (2010, 2011)

E

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDLGQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2020)

E

PF06049 // ENSGT00910000143988_0_Domain_21 (2020, 2028)

TLSPDLTQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TLAPDLGQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

E

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLGQ

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

E

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDLTQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TRSPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

L

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

PLSPDLRQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

E-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TLSP-DLTQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

TRSPDLGQLPLSPDLG
Q-------------------ET-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-LSPDLT-QT---------------------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
TQ

ENSGT00910000143988_0_Linker_36_37 (2163, 2167)

TT--

PF06049 // ENSGT00910000143988_0_Domain_37 (2167, 2175)

-RSPNLGQ

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

L

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

PLSPDLGQ

ENSGT00910000143988_0_Linker_38_39 (2184, 2185)

E

PF06049 // ENSGT00910000143988_0_Domain_39 (2185, 2195)

TLS--PDLTQTT----------

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

-LSPDLTQ

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2224)

TRSPD
LGQ

ENSGT00910000143988_0_Linker_43_44 (2224, 2225)

E

PF06049 // ENSGT00910000143988_0_Domain_44 (2225, 2233)

TLSPDLGQ

ENSGT00910000143988_0_Linker_44_46 (2233, 2234)

E

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TLSPDLGQ

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

E

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TLSPDLTQT--------------------

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2313)

TRS-PD---
-----------------------------LGQ

ENSGT00910000143988_0_Linker_48_54 (2313, 2314)

L

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLFPDLGQ

ENSGT00910000143988_0_Linker_54_55 (2322, 2323)

E

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDRS--Q

ENSGT00910000143988_0_Linker_55_56 (2333, 2334)

M

PF06049 // ENSGT00910000143988_0_Domain_56 (2334, 2342)

TLPPHLG
Q

ENSGT00910000143988_0_Linker_56_57 (2342, 2343)

T

PF06049 // ENSGT00910000143988_0_Domain_57 (2343, 2352)

SPPPDP-DQT-------------PHASESSQS----LPLPEFDPI

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

FP-------YP--
-----DLGQRP-STPLSPTLNSTFLPRELNPLVVL-GFSDD-DGDYTEIIPREKE-DSSE
E---D-YF-EVDYVAYDDPYKTDIRTDINSSRNPDNIAAWYL-RSN--NGNRKNYYIAAE
EISWDYAKFAQS---ELDD-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------EDS--TVPKDTVYKKVVF-RQYLDSTFTRRDPR
GEYEEHLGILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAIQPNGSYTYVWHATGRSGPENPGSACRAWAYYS-AVNPVRDIHSGLIGPLLICR
RGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKKP--QRSWRRVSLEVK------QSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNLGGSQDIHVVHIHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFSG-YWEPKLARLNNGGSYNAWITEKTSTEFDSKPWIQVDMQREILVTGIQSQGAK
HYLKSYYTTEFRAAYSSDQTNWQIFKGNSTKNVMYFDGNSDASTIKE-NRFDPPITARYI
RIYPTRFYNKPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEING--CSTPLGMESGKIENT

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKAN-HKQWLQIDLLKXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXIFEGNSNIKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFLVGPRLCVLVVLGTS---WAGWGSYPAEAARLRQFYVAAQGILWNY-HPETTDP-SLN
S-KPSFKKIVYREYEAHFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDTMKVHFRNKADKPISIH
PQGIKYSKFSEGASYTDHTFPAERMDDAVAPGEEYTYQWVISEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSWSQ-------
---------------SPSLMYTVNGFVNRTMPDVTVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTITLVSATSTTANMTMSPEGKWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRHMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPTTMDKKYR-------SLHLDNFSNQIGKQYKKVIYRQYEDETFSKR
MESS-GTKQ

PF07732 // ENSGT00910000143988_0_Domain_3 (490, 567)

SGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGS-HTMIRPVQPGEIYTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDQRGIQKAADIEQQAVFAVFDENKSWYIEDNINKFCENPEEVKRDDPKFY
ESNIMS-----TLN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGIYDDILTIHFTGHSFIYGKK
HEDTLTLFPMSGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPRH
KNLRLRFRDVKCIRNDDDEDSYE--IYEPFV----PT----P--------DSMTTRK-IH
DSLENEFSIESEDEDYQYLLASSLGIRSFRNSSWNQEEDE-FNLTALALENSS--ESIFP
NIDKVNDSKS-SPGNLSG---------------------IASNNLKESQQTLPGSGATMT
GTLPEDLTGLGENSVLNSPTE---HHSSSYYEHDV-----------EDS-QSDITVVHLL
PL--GEKGSGSQGHAKHKKAKLGRAHLM-----------------KYRFPQIKVPAQKTR
RHSNPKNT------------------NAGVRSSEEIPTDLFLLKQTNTSNFLDREWYLAS
EKSSYEIIPANG--EDT-AVDKLQNGPQNQNISGPWD-NNT--STTKTTGKPHDLPMFSG
IRRKSPQVRQEKGNRNFNNG-QFIKTRKKKKDKKMAIHSLLSP-----------------
-----------------------------------------------------------R
GFHPLRGHAQPTFLDQR-LNHSLLPHKSNETA-----LPIDLNQTSPLT-SVDR--SLPH
HHQGPPHGS-RQMSSALDVYQSLPPE-----EQSPIFPTQDPDQTHSTTDLSH-------
-------RSFPPEPSQG-LDYD-LS-HESY--PEDIGQ--------------TSFFP-DQ
SQKS----------------------LSSEDGQASPSSDPSLFTISPELDQTIISPDLGQ
MTLSPDDNQ--KTSSPDL------------------------------------------
------------------------------------------------------------
--------GQV-PLYPDDYQMP--SSPDLG-QVPF-------------------------
------------------------------------------------------------
------SPDDNQKAFPHDLSLLPLS---------PEFDE--PVLSQDLDQMPQS-SDL--
S----------QVTLSPDLSLLTLSPD--FDEIILSPDLSQVTLSPDLI--QTSPPLNHR
HETASEDP-DQA-------------SDPSYSGQF----LPLPELNQTLL-------HP--
-----DLIH-TPSPSPSPQLNNTSKSTELNPLVVV-GLSRV-DGDDVEIISNEEL-ESID
D---D-Y-TEDYYVNYNDPYKTDTRTDTNSSRNPDTIAAWYL-RGH--RGNKQYYFIAAE
EISWDYSQFSQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SEDSD--AIPRDTTYKKVVF-RKYLDSTFTRRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLFYEKSSEGKTYEDDSPEW
FQEDNAVQPNSSYTYVWHATERSGPENAGSACRAWAYYS-AVNVEKDIHSGLIGPLLICR
KGTLHQESNLPMDRREFVLLFMAFDEKKSWYYEKS---KRSWRIDSPEVK------NSHK
FYAINGMIYNLPGLIMYEQEWVRLHLLNMGDSQDIHVVHFHGQTLLDNSTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEIGENQIAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASGHLS-YWEPKLARLNNGGSYNAWSLEKSALDFAFKSWIQVDMQKEAVITGIQTQGAK
HYLKSCFITEFHVAYSTDQTNWQIFRGNSTKNIMDFAGNSDASTIKE-NRFDPPIVARYI
RIHPTKSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCELNG--CSTPLGLEDGRIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYSI
QYSDQGMEWKPYRQKS-SMVDKIFEGNSNTKGQMKNFFNPPIISRFIRII-----PKSWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFPGCPRLWVLVVLGTS---WVGWGSQGTEAAQLRQFYVAAQGISWSY-RPEPTNS-SLN
LSVTSFKKIVYREYEPYFKKEKPQSTI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGTLTEDGTQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDVTVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNLKKITREQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKHYKKVMYTQYEDESFTKH
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIVRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVMATRK-MH
DRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEE-FNLTALALENGT--EFVSS
NTDIIVGSNYSSPSNISK---------------------FTVNSLAEPQKAPSHQQATTA
GSPLRHL--IGKNSVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIRLL
SL--GAGEFKSQEHAKHKGPKVERDQAA-----------------KHRFSWMKLLAHKVG
RHLSQDTGSPSGMKPWEDLPSQDTGSPSRMRPWEDPPSDLLLLKQNNPSKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNWLISPQN--ASRAWG-EST--PLANKPGKQSGHPKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKHTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFPERR-LKHSLVLHKSNETS-----LPTDLNQTLPCM-DFGWIASLPD
HNQNSSNDT-GQTSCPPGLYQTVPPE-----EHYQTFPIQDPDQMHSTSDPSH-------
-------ISSSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTITSP-DL
SQVT---------------------LSPELSQT-NPSPDLSHTTLSPELIQTNLSPALGQ
MPISPDL--SHTTLSPDLSHTTLSPDLSHTTLSP--------------------------
------------------------------------------------DLSHTTLSPDL-
-S---------------------------------------HT-----------TLSLDF
SQTN---LSPEL---------SQTNIS--PALGQMPLSPD-PSH-TTLSLDHSQTNLSPE
LSQTNL------------------SPDLSEMPLFADLSQ--IPLTPD----------L--
D----------QMTLSPDLGETDLSPN--FGQMSLSPDLSQVTLSPDIS--DTTFLPDLS
QISPPPDL-DQI-------------FYPSESSQS----LLLQEFNESFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTTYKKVVF-RKYVDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSTYTYVWHATERSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEMK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDLQ

PF00754 // ENSGT00910000143988_0_Domain_66 (3060, 3197)

M
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NWFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MFPCCPRLWVLVVLGTS---WVGWGRQGTEAVQLRQFYVAAQGISWSY-RPESTNS-SLN
LSATSFKKIVYREYEPYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIIKVHFKNKADKPLSIH
PQGIRYSKLSEGASYLDHTFPVEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYY
SHENLIEDFNSGLIGPLLICKKGILTEDGKQKTFDKQIVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSL--TPKHL-QAG--MQAYIDI
KNCPKKTRNPKKITREQRRHMKRWEYFIAAE-----------------------------
---EIIWDYAPVIPANMDKKYR-------SQHLDNFSNQIGKLYKKVMYTQYEDESFTKR
TVNP-NMKEDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEVNS
SFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIG
LLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ESNIMSNFTLSAIN-------------------------------------G--------
--------YVPES------ITTLG-FCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTSMNSSPRS
KKLRLKFRDVKCIPDD-DEDSYE--IFEPPE-----S-------------TVTATRK-MH
DRLETEDEESDTDYDYQSRLAAALGIRSFRNSSLNQEEEE-YNLTALVLENGT--EFISS
NTDIIVGSNYSSPNNTSK---------------------LTVNNLAEPQKTPSHQQATTA
GSSLRHL--TGKNLVLNSSTA---EHSSPYSEDPI-----------EDPLQPDVTGIHLL
SL--GAREFKNQEHAKHKGPKVERDQAA-----------------KHGFSWMKLLAHKVG
RHLSQDTG-----------------SPSRVRPWEDLPSDLLLLKQNNSPKILVGRWHLAS
EKGSYEIIQDTD--EDT-AVNNRLISPQN--ASRAWG-EST--PLANKPEKQSGHSKFPR
VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKK-EKRTHHAPLSP-----------------
-----------------------------------------------------------R
TFHPLRSEAYNTFSERR-LNHSLLLHKSNETS-----LPKDLNQTLPSM-DFSWIASLPD
HNQNSSNDT-GQTSSPPGLYQTEPPE-----EHYETFPIQDPDEMHSTSDPSH-------
-------R

PF06049 // ENSGT00910000143988_0_Domain_8 (1869, 1877)

SFSPELSEM-LEYD-RS-HKSF--PTDISQ-M-SPSSEH-EVWQTVT

PF06049 // ENSGT00910000143988_0_Domain_10 (1916, 1923)

SP-DL
SQ

ENSGT00910000143988_0_Linker_10_11 (1923, 1945)

VT--------------------

PF06049 // ENSGT00910000143988_0_Domain_11 (1945, 1953)

-LSPELSQ

ENSGT00910000143988_0_Linker_11_13 (1953, 1956)

T-N

PF06049 // ENSGT00910000143988_0_Domain_13 (1956, 1963)

FSPDLSH

ENSGT00910000143988_0_Linker_13_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPELSQTNLSPALDQ
MPM

PF06049 // ENSGT00910000143988_0_Domain_17 (1984, 1992)

SPDL--SHTTLSPDLSHTTLSLDLSQTN

PF06049 // ENSGT00910000143988_0_Domain_20 (2012, 2019)

LSPELSQTNLSPALGQM

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

PLSPDLSH

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLSHTTLS-----------------------T-N

PF06049 // ENSGT00910000143988_0_Domain_28 (2076, 2084)

FSP-ELSQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2086)

TN

PF06049 // ENSGT00910000143988_0_Domain_26 (2086, 2093)

LSPDLSE

ENSGT00910000143988_0_Linker_26_31 (2093, 2101)

MPLSPDLI

PF06049 // ENSGT00910000143988_0_Domain_31 (2101, 2111)

TS---PDLSQ

ENSGT00910000143988_0_Linker_31_30 (2111, 2113)

V-

PF06049 // ENSGT00910000143988_0_Domain_30 (2113, 2163)

TLSPELS-----------------------------------------
-QTN---FSPDLSHTTLSPELSQTNLS--PALDQMPLSPD-LSH-TTLSPDLSHTTLSPDLN-------------------------------------------------------L--S----------QTNLSPELSQTNLSPA--LRQMPLSPDLSQVTVSSDIS--ETTLLPDFSQMSPPLDL-DQI-------------FYPSESSQS----LHLPEFNETFP-------YP-------DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSED---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAEEISWDYSEFVQR---ETD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVSL---LTSRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATDRSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQKGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHEFHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWALLPGAFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDSQIKASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMESGKIENKQITASSFKKSWWG---DYWEPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAITTQGCKSLSSEMYVKSYTIHYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWNQSIALRLELFGCDVY

PF06049 // ENSGT00910000143988_0_Domain_32 (2113, 2163)

TLSPELS------------------------------------------Q

ENSGT00910000143988_0_Linker_32_37 (2163, 2168)

TN---

PF06049 // ENSGT00910000143988_0_Domain_37 (2168, 2175)

FSPDLSH

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPELSQTNLS--PALDQM

PF06049 // ENSGT00910000143988_0_Domain_40 (2196, 2206)

PLSPD-LSH-

ENSGT00910000143988_0_Linker_40_41 (2206, 2207)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2207, 2215)

TLSPDLSH

ENSGT00910000143988_0_Linker_41_43 (2215, 2216)

T

PF06049 // ENSGT00910000143988_0_Domain_43 (2216, 2222)

TLSPD
LN-------------------------------------------------------L--
S----------QTN

PF06049 // ENSGT00910000143988_0_Domain_51 (2295, 2302)

LSPELSQTNLSPA--LRQM

PF06049 // ENSGT00910000143988_0_Domain_54 (2314, 2322)

PLSPDLSQVTVSSDIS--ETTLLPDFS
QMSPPLDL-DQI-------------FYPSESSQS----LHLPEFNETFP-------YP--
-----DLGQMP-SP-SSPTLNDTFLSKEFNPLVIV-GLSKD-GTDYIEIIPKEEV-QSSE
D---D-YA-EIDYVPYDDPYKTDVRTNINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSEFVQR---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------IEDSD--DIPEDTVYKKVVF-RKYLDSTFTKRDPR
GEYEEHLGILGPIIRAEVDDVIQVSL---LTSRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATDRSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGILHKDSNMPVDMREFVLLFMTFDEKKSWYYEKKS--RSSWRLTSSEVK------KSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQH-QLGVWA
LLPGAFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEFLG-YWEPRLARLNNGGSYNAWSVEKLAAELASKPWIQVDMQKEVIITGIQTQGAK
HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKE-NQFDPPIVARYI
RISPTRAYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAITTQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRLKS-SMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVI-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

MFPGCPPLWVLVVLGTS---WAGWGSPGAEAAQLRQFYVAAEHISWSY-HPEPTNP-SLN
AFATSFKKIVYREYEAYFKKEKPRSGI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKIHFKNKADKPLSIH
PQGIKYSKFSEGASYPDHTSPVEKMDDAIAPGQEYTYEWIISEDSGPTHDDPPCLTHIYY
SHENLVQDFNSGLIGPLLICKKGTLSEDGTQKMFEKQFVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDIMVCARDHVSWHLIGMSSGPEMFSIHF
NGQVLEQNHHKVSAITLVSATSTTANMTVSTEGRWIISSL--TPKHL-QAG--MQAYINI
KNCPKKTRMPNKMTLEQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIVPANMDQEMQ-------I----------ELHWNTIFYLSDSQVQM---
-----------------------TSSITFKNM-ASRPYSIYPHGVTFSP----YEDGVNS
SSTSGS-NTMIRAVKPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIIRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYEKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSSPRS
KNLRLRFRDVKCILDD-DEDSYE--IYEPPS-----S-------------TAMATRK-MH
DFPESNDDENDAEDDYQYILASELGIRSLRNSSLNQEEDK-FNLTALAMENSS--EFISP
STDTAVGSNSSSPSNVSS---------------------LTVNNLAGPQKTLPHPGATTA
GHPLGHFNGLDKNSVLNSSMA---EYSSPYSEDPS-----------EDPLQSDVTGISLL
PH--GARGFRRQEHAKHKGSKKERYQAA-----------------KHRFSQMKLLAHKIG
RHFSQDNGSPSGM-----------------GPWENLPSDLLLLKENDPSKILNGKWHVVS
EKGNYEIIQDTQ--EDM-AVNKPLTSPQN--VSSPWGSEST--PLINNPGNQSGHLKFSR
VRHKYLHVRQDVRNSRLKKSPFFIRTRKKKKGEKLGNHVPLSP-----------------
-----------------------------------------------------------R
GFHPLRGAASATFSDQM-LNHSLLLHKSNETS-----LPTDLNQTLPSM-NLDLMTSLPD
HNQNPPNDT-SQTSSPPDLYQTVPPK-----EHHQTFPIQDPDQMHSTTDPSH-------
-------RSSPPELSWM-LDYD-LS-HQSF--PADLGQ-L-SPYLEH-EVWQTAISA-DV
NLGT---------------------ISPDLSQS-SLSPDLGT--ISPDLSQSSLSPDLGT
T-------------SPDLSQSSLSPDLG--TISPDLSQSSLSPDLGTSPDL---SQSSLS
--PDLGTI----------------------------SP-DLSQSSLSPDL---------G
TISPDL--SQS-SLSPDLG--T--ISPDLS-QLSLSPD-IGTI-------------SPDL
SQSS---LSPALDQMTLSAEFTQTSLS--LDVSQMPLSPD-LSH-TTL------------
---------------------------------SPDLSQ--TTPSPDLGQMSLS-PDL--
S----------QMTLSPDPSETNISPD--FSHISLSSALGRVALSPDIS--QTTLPPDLR
QTSPLPDL-DHT-------------FYPSESSQS----LPLPEFNETFP-------YS--
-----DLGQML-S----PTLNDTFISKEFNPPVVV-GLSRD-DGDYIEIIPRQED-QDSD
E---D-YV-EIDYVAYSDPYQTDIRTDINSSRNPDNIAAWYL-RSN--NGNRRNYYIAAE
EISWDYSKFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDID--NIPEGTIYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVPPNSSYTYVWHATDRSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGTLHKESNMPVDMREFVLLFMVFDEKKSWYYEKKS--TRSWRLASSEVK------NSHE
FHAINGMIYNMPGLRMYEQEWVRFHLLNVGGSQDIHVVHFHGQTLLENGHQQH-QLGVWP
LLPGAFKTLEMKPSKPGWWLLNTEVGENQRAGMQTPFLVIDKECKMPMGLSTGIVSDT

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLG-YWEPKLARLNNIGSYNAWSVEKLATGFGSNPWIQVDMQKEVVITGIQTQGAK
HYLKSLYTTEFNVAYSSDHTNWQIFKGNSTKNVMYFDGNSDASSIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAMITQGCKSLSSEMYVKSYTI
HYSDQGVEWKPYRQKS-SMVDKIFEGNSNTKGHVKNIFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

------------------------------------------------------------
--------------------------------------------MKVHFKNKADKPVSIH
PQGIKYSKFSEGASYSDHTFPVEKMDDAIAPGQEYTYEWKISEGSGPTHDDPPCLTHIYY
SYENLIQDFNSGLIGPLLICKKGALTDNGVQKMFDKQHVLMFAVFDESKSWSP-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDQVSWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSATSTTANMTMSPEGKWIISSL--VPRHF-QAG--MQAHIDI
KNCAKKTRNPKKLTRDQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPVNMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
MEND-NIKEDGILGPIIRAQVRDTLKIVFKNM-ASRVYSIYPHGVTFSP----HEDDANA
SLASDN-TTMVRAVRPGETHTYKWNILESDEPTEHDAQCLTRPYYSHVDVTRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCYDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTINSNPRN
KNLRLRFRDVKCIRDD-YEDSYEI-IYGPPA----ST--------------AMTTRK-MR
DSSENMGEEVDDDDDYQNSLASWLGIRSFRNSSLNQEEEE-FNLTALALENNS--EFIPP
D--TALSSNSSSLSNISR---------------------FTVYNFAKPQKTLPHSAATMA
GRSLGH-IGLDKNSALNRSTA---EHSSPYSEDSV-----------EDPLQPDITEISLL
PF--DAEGFRGQEHAKHKGSKKGSEHTA-----------------KHRFSQVEFSAQKTG
RYLSQGNS-----------------SPSRMGSWEDLPSDPLLLKQKNPSKVVNGKWHVVS
EKGSYEIVPDAD--EDM-AVDKLLDSPRN--ASRTWG-ENI--PLIKKHRKQSGHPRFSG
IRNKSLQVKQDRGNSGLKKIPFFIKTRKKKKEVKFAHHIPLSP-----------------
-----------------------------------------------------------R
GFHPLRGKANTTFSDRR-LDHSLLPHKSDEAS-----FPTDLNQTFPSV-NLSQLASLPD
HNHNAPNDT-SQMSSPLDLYQAIPPE-----EYYQAFPIGESDQIHSTTDSSH-------
--------TSPPESGQM-LDYD-LR-KKPF--PTDIDQ-V-FPSLEP-EAWQATLSA-DL
SQLT---------------------ISPDLDH----------TTFSPDLSQTTLSPDLSK
TTLSS-----------DFDHTAF------------------SPDLIQTTFSPDLSQTNLS
PDL-----------------------------------------------SKTTLSPDFD
HTTFSPDLDQA-TFSPDLDQAT--FSPDLS-QT---------------------TLYPDL
DQTS---FSSDLSHTTLSPDLSQTPFS--P------------------------------
--------------------------DLDQETLSSDISQ--TTLFPDLDQMLLY------
------------------------------------PDLNQATLSPNIS--QTALPPDLD
T-SLPPDL-DQT-------------SYTSESTQS----LLPPEFGQISS-------HP--
-----DIGQVP-----SPTLNNTLVPRELNPPVVI-GLSAN-DGDYIEIIPRQKE-ESSE
E---Y-TA-EIDFVAYDDPYQTDTRTDINSSRNPDSIAAWYL-RSN--SGNRKYYYIAAE
EISWDYSKFAQS---EDI------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------D-DD-----PENTIYKKVVF-RKYLDSTFTKRDPL
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2843)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATTRSGPESPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICE
KGVLDK-SNTPMDMREFVLLFMIFDEKKSWYYEKKTQSPRPWRLASSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGSSQDIHVVHFHGQTLLENGTRQH-QRGVWP
LLPGSFKTLEMKASKAGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLG-YWEPRLARLNNGGSYNAWITEKPSPELDTKPWIQVDMQREVVLTGIQTQGAK
QYLKSYYTTQFSVAYSSDRTNWQIFKGNSTRNVMYFDGNSDASTIKE-NRFDPPIVARYI
RISPTRFYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVNG--CSAPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNHQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYSI
QYSDQGMEWKPYRQGS-SMVAKIFEGNNNIKGHVKNSFNPPIMSRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

MAPGCARLWVLVLLGASCTGWGSWGSWGAEAARLRQFYVAAQGISWNY-RPEPTNP-SSN
T---SFKKIVYREYEPYFQKEKPRSKI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIIKVHFKNKADKPISIH
PQGIKYSKFSEGASYSDHTFPMEKMDDAIAPGQEYTYEWHISEDSGPTHNDPPCLTHIYY
SYDNLIQDFNSGLIGPLLICKKGTLTENGIQKMFDKQHVLMFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSATSTTANMTMSPQGRWIISSL--ITRHF-QAG--MQAYIDI
KNCAKKTRNPKKLTRDQRRYMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPANMDKKYR-------SLHLDNFSNQIGKQYKKVVYKQYQDESFTKR
LENL-NIKEDGILGPVIRAQVRDTLKIVFKNM-ASRVYSIYPHGVTFSP----YEDEVNS
SFTSDN-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDVTRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSIGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTINSSPRS
KNLRLRFRDVKCIRDD-YEDSYEI-IYESLA----PT--------------VMTTRK-MR
DSPEDNGDENDADYDYQNNLASWLGIRSFRNSSLNQEEDE-FNLTALALENNS--EFDPP
NTDTALNSNSSSLRNFSR---------------------LIVYNFAKPQKTLPHPEATTA
GPPLGH-IGLDKNSVLNHSTA---EHSSPYSEDSM-----------EDPLQSDITGVKLL
PL--DAEGFRNQEHARHKGG----EHTA-----------------KHKFSQVGFSAPKPG
RHLSQGNS-----------------SPSRIGPWKDLPNDLLLLKQNNPSKILNGKWHLVS
EKGSYEIVPDA---EDM-AVDKLLDSPQN--TSKSWG-ESI--PLSNKHRKQSGYPKFSG
VRNKTLQVKWDRGNGGLKKSLFLIKTRKKKKEQKLAHPIPLSP-----------------
-----------------------------------------------------------R
SFHPLRGKANTTFSDRR-LDHSSLLHKSNGRS-----FPAGLNQTFPSL-NLTLLASLPD
HNQNPPNDT-SQTSSPLDLYQTVLPE-----EHYQTFPIQDSNSMHSTVDSSH-------
--------TSPPEPGQM-QDYD-LR-HEPF--PTDIGQ-M-FPSLEP-EAWQATISA-DL
DQTT--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LFPDLSK----------

ENSGT00910000143988_0_Linker_12_14 (1963, 1964)

T

PF06049 // ENSGT00910000143988_0_Domain_14 (1964, 1972)

TLSPDFDQ

ENSGT00910000143988_0_Linker_14_16 (1972, 1973)

T

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

TLSPDLDQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

TFSP-----------DLDQTTFSADLSQT

PF06049 // ENSGT00910000143988_0_Domain_20 (2011, 2019)

TLSPDFDQ

ENSGT00910000143988_0_Linker_20_21 (2019, 2021)

TM

PF06049 // ENSGT00910000143988_0_Domain_21 (2021, 2028)

LSPDLDQ

ENSGT00910000143988_0_Linker_21_22 (2028, 2029)

T

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2037)

TFSPDLSQ

ENSGT00910000143988_0_Linker_22_23 (2037, 2038)

T

PF06049 // ENSGT00910000143988_0_Domain_23 (2038, 2046)

TLS
PDLSK

ENSGT00910000143988_0_Linker_23_24 (2046, 2047)

T

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDFDQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

T

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TLSPDLDQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TFSPDLDQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

T-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TFSP-DLSQ

ENSGT00910000143988_0_Linker_28_26 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_26 (2085, 2093)

TLSPDLSK

ENSGT00910000143988_0_Linker_26_29 (2093, 2094)

T

PF06049 // ENSGT00910000143988_0_Domain_29 (2094, 2102)

TLSPDFD
Q

ENSGT00910000143988_0_Linker_29_31 (2102, 2103)

T

PF06049 // ENSGT00910000143988_0_Domain_31 (2103, 2111)

TLSPDLDQ

ENSGT00910000143988_0_Linker_31_33 (2111, 2113)

T-

PF06049 // ENSGT00910000143988_0_Domain_33 (2113, 2121)

TFSPDLDQ

ENSGT00910000143988_0_Linker_33_34 (2121, 2124)

TT-

PF06049 // ENSGT00910000143988_0_Domain_34 (2124, 2133)

-FSPDLS-QT---------------------

PF06049 // ENSGT00910000143988_0_Domain_36 (2155, 2163)

TLSPDL
SK

ENSGT00910000143988_0_Linker_36_37 (2163, 2167)

TT--

PF06049 // ENSGT00910000143988_0_Domain_37 (2167, 2175)

-LSPDFDQ

ENSGT00910000143988_0_Linker_37_38 (2175, 2176)

T

PF06049 // ENSGT00910000143988_0_Domain_38 (2176, 2184)

TLSPDLDQ

ENSGT00910000143988_0_Linker_38_41 (2184, 2185)

T

PF06049 // ENSGT00910000143988_0_Domain_41 (2185, 2233)

TFS--PD-----------------------------
---------LDQ

ENSGT00910000143988_0_Linker_41_46 (2233, 2234)

T

PF06049 // ENSGT00910000143988_0_Domain_46 (2234, 2242)

TFSPDLSQ

ENSGT00910000143988_0_Linker_46_47 (2242, 2243)

T

PF06049 // ENSGT00910000143988_0_Domain_47 (2243, 2251)

TLSPDLSQ

ENSGT00910000143988_0_Linker_47_49 (2251, 2252)

T

PF06049 // ENSGT00910000143988_0_Domain_49 (2252, 2262)

TLSPDFDQ--

ENSGT00910000143988_0_Linker_49_50 (2262, 2263)

T

PF06049 // ENSGT00910000143988_0_Domain_50 (2263, 2271)

TLSPDLDQ

ENSGT00910000143988_0_Linker_50_48 (2271, 2272)

T

PF06049 // ENSGT00910000143988_0_Domain_48 (2272, 2293)

TFS-PDF--
G----------Q

ENSGT00910000143988_0_Linker_48_51 (2293, 2294)

T

PF06049 // ENSGT00910000143988_0_Domain_51 (2294, 2302)

ILSPDFDQ

ENSGT00910000143988_0_Linker_51_52 (2302, 2304)

IL

PF06049 // ENSGT00910000143988_0_Domain_52 (2304, 2321)

LSP-----------DLS

ENSGT00910000143988_0_Linker_52_55 (2321, 2323)

QA

PF06049 // ENSGT00910000143988_0_Domain_55 (2323, 2333)

TLSPDIS--QTALPPDLR
QTSLPLDL-DQT-------------SYTSESSPS----ILLPEFGQTLP------

PF06049 // ENSGT00910000143988_0_Domain_60 (2396, 2410)

-YP--
-----DLGQ

ENSGT00910000143988_0_Linker_60_61 (2410, 2769)

VP-SLTPSPTLNNAFPPEELNPPVVV-GLSAN-DGDYIEIIPRQKE-ESSE
E---Y-SA-EIGYVTYDDPYQTDTRTDINSSRNPDNIAAWYL-RSN--NGNRKYYYIAAE
ELYWDYSKFAQS---EDV------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------D-DHI--HAQENTVYKKVVF-RKYLDSTFTKRDPL
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2842)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FKEDNAVQPNSSYTYVWHATTRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGVLDK-SNTPMDIREFVLLFMVFDEKKSWYYKKKAQSPRSWRLTSSEAK------HSHE
FHAINGMTYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKSSKPGWWLLNTEVGENQRAGMQTPFLIIDRECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLG-YWEPKLARLNNGGSYNAWIPEKPSTELDSKPWIQIDMQREVVFTGIQTQGAK
QYLKSYYTMEFYVAYSSDRTNWQIFKGNSTRNVMYFDGNSDASTIKE-NNFDPPIVARYI
RITPTRSYNRPALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPFRARLNAQG-RVNAWQAKANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRQKS-SMVDKIFEGNNNVKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

-------------LRQKLGGPQ----VRGTSDSDSDFYVAAQGIRWDY-RPEPADP-SSN
PFATSFQKIVYREYEPYFQKEKPRSKI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYSDHTFPVEKLDDAIAPGQEYTYVWNISEDSGPTHNDPPCLTHTYY
SYENLVQDFNSGLIGPLLICKKGTLTEDGIQKMFDKQHVLMFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKISAITLVSSTSTTANMTVGPKGKWIISSL--FPSHF-QAG--MQAYIDI
ASCAKKTRNPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDESFTKR
MENP-NIKEDGILGPIIRAQVRDTLKIVFKNM-ASRVYSIYPHGVTFSP----YEDEVNS
SFTSGN-NTMIRAVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYIEDNINKFCENPDKVKRDDPKFY
ESNVMS-----TIN-------------------------------------G--------
--------YVPES------IPTLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFVYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWILTTVNSSPRS
KNLRLRFRDVKCIRDE-DEDSYEI-IYEPLA----ST--------------AMTTRK-MR
DSSENRGEEDDADYDYQENLASWLGIRSFRNSSLNQEEEE-FNLTALALENYS--EFIPS
STDPAIRSNSSFLSSISR---------------------LIVHNFAGPHKTLPRPEATTA
GPPLGR-IGLDKKSVLNSSKE---EHSSPYSEDSM-----------EDPLPSDITGISLL
PL--DADGFRNQKHAKHNGSKKGRDHTT-----------------KHGISQVGLSAYKTG
RHLRQGNS-----------------SPSRTGAWEDLPGDLLLLRQKNPSKILNGKWHPAS
EKGSYEIVQDAD--EDT-AATKLLSSPQN--ASRTLG-KSS--PFTNKDRKQSGHPPFSG
IRKKFLQERQDGGNGRLKKSPFFIKTRKKKKEEKLAHHIPLSP-----------------
-----------------------------------------------------------R
GFHPLR-KANTTFADRR-LNHSLLFHKSKETP----FYPTDLNQTFPSV-NLSLIASLPN
HNQNPPNDT-SQTSSPSDLYQTITPE-----ERYQTFSIQDSDQMHSTTESSH-------
--------GSLPEPGQM-LNYD-LR-NKSF--PTDIAQ-M-FPSLEP-EAWQTTISA-DL
SQPT---------------------LSPDLSQ----------TAVTPDLGQMPLSPDLSQ
EPLLS-----------DLS---------QMALSPDHRQTTLSPDLSQTDV----------
------------------------------------------------------------
----SPDLSEI-TISPDLIKMN--LPPDLS-QM---------------------PFFPDL
SQET---LSSDLSQMPLSPDLGQETLS--SD-----------------------------
------------------------------------VGR--TTLS----------PDT--
------------------------------SQTTLSQDLGQIPLSPDIS--QTALSPDLR
QTSSPPDL-DQT-------------SNTSEFSHS----LLLPEFGQTSP-------SP--
-----DLSQVP-SPPLSSTVNNTFIPRELNPPVVI-GLSGN-DGDYIEIIPRQKE-ESSE
E---I-ID-DIDYVAYDDPYQTDVRTDINSSRNPDNIAAWYL-RSN--NGNKKYYYIAAE
ELSWDYSKFAQS---EVD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDID--DVPENTVYKKVVF-RKYLDGSFTKRDPT
GELEAHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2843)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKSYEDDSPEW
FKEDNVVQPNSSYTYVWHATPRSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICQ
KGVLHKESNTPVDMREFVLLFMVFDERKSWYYEKKPQSPRAWRLSSSEEK------TSHE
FHAINGMIYSLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKSGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGIIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
RASGHWG-YWEPKLARLNNGGSYNAWITEKPS-EVDLKPWIQVDMQREVVLTGIQTQGAK
HYLKSYYTMEFYVAYSSDQTNWQIFKGNSTRNVMYFDGNSDASTIKD-NQFDPPIVARYI
RISPTRSYNRAALRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3256)

LQGCEVNG--RESSRYGRMARTFSSLQSLGCLEKPWRN---RFC
C------NCLI-HMS

PF00754 // ENSGT00910000143988_0_Domain_68 (3256, 3369)

SSFSQANNNKQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGVDWKSYRQKS-SMADKIFEGNNNVKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

----------------------------------------------------------LN
SFTPSFKKIVYREYEPYFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 201)

LLGPTLYAEVGDIMKVHFKNKADKPVSIH
PQGIKYSKFSEGASYSDHTSPVERMDDAVAPGQEYTYEWVISEDSGPTQDDPPCLTHIYY
SYKNLTKDFNSGLVGPLLICKKGTLTEDGTQMMFDKQFVLLFAVFDESKSWDP-------
---------------SPSLMYTVNGYVNRTMPAITVCAHDHISWHXXXXXXXXXXFSIHF
NGQVLEQNHQKVSTVTLVSATSTTANMTVSPEGKWTISSL--IPRHF-QAG--MQVHIDI
VNCPKKTRNVKKLTLEQRRYIKRWEYFIAAE-----------------------------
---EVMWDYAPIIPASMDKVHL-------SLQ--G-------------------------
-------------------FKACSLSIVFKNT-ASRPYSIYPHGVTFSP----YEEEVNS
SSTSGN-HTMIRAVQPGEIYTYKWNILESDEPTDSDAQCLTRPYYSDVDITRDIASGLIG
LLLICKSRSLDMRAY-RAADIEQLAVFAVFDENKSWYIEDNINKFCENPEMVKRDDPKFY
QSNIMSSKS---------------------------------------------------
---------------------EHW-FCYDDTVQWHFCSVGSQDDILTIHFTGHSFIYGKR
HEDTLALFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLMTMNSSPRN
KNLWLRFRDVKCIGDD-DEDSYK--IYAPPE----VS-------------TPMDVRK-IK
FPSENEHEEINPDDDYQDDLASALGLRSFRNSSLNQNEDE-FNLTALALENSS--ELISP
STDVVIGSNSSF----AR---------------------TVVNNITEPQKTLPHVEASIA
VHLLEHFSGSDENPV---------------------------------------------
------------------------------------------------------------
----------------------------------DLPSALLLLKQKNPSRILDEQWHVVS
EKGSYEIIQDND--EDM-AVTELLNSPQN--VSRTLK-ENN--QPENKPGEHSDHSKYSG
FRPRSLHVRQGGENGELKKIPVFIKTRKKKKEPKIAHHIPFSP-----------------
-----------------------------------------------------------V
DIHSLKRAHYTRFSDKR-LKHSLLLHKLSKTS-----LPIDLNQTLPSI-SPVQIDSLPV
HNLSLTSNT-GQTNIPPDLSQTVAPG-----EYNQTSLIQDPVQMHSTTDRSH-------
-------RSSPAGLSQI-VSYD-LN-HELH--PVDTGPLL-SHAQEH-EAWQMTTFS-GL
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------KFNQTSP-------YP--
-----DLGHIPPSPLPSPSLNDTFISNEFNPVVIV-GLSRD-DEDYIELVPRQEV-QIPE
E---D-YA-EVDYXXYDDPYQTDGRTDINSSRNPDDIAAWYL-RSN--KGNRKYYYIAAE
EISWDYAEFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEASD--DVKKDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVHFKN-LASRPYSIHAHGLSYEKSSEGRSYDDDSPEW
FQDDNAILPNNSYTYVWHATDRSGPETSGSACRAWAYYS-AVNPEKDIHSGLIGPILXXX
XXXXXXXXXXXXXXXXXVLLFMVFDEKKSWYYGKS---KRTWRLESSEVK------NSHE
FHAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEIGENQIAGMQTPFLIIDKGIVFFFL-----------
--FSNLG

PF00754 // ENSGT00910000143988_0_Domain_66 (3068, 3147)

-YWEPKLARLNNTGSYNAWSVENSRLKTGSKPWIQVDMQKEVIVTGIQTQGAK
HYLKSLYTTEFYVAYSSDRSSWQIFKGNR-------------------------------
--------------------------CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQAKANNNQQWLQVDLLKIKKVTXXXXXXXXXXXXXXXXXXXTI
YYSDQGVEWKSYREKS-FMVDKVFEGNSNVNGHMKNFFNPPIIARFIRII-----PKTWN
QSIALRLELYGCDFY---------------------------------------------
-----

MLLVCPCFFLLVVLGTR---WAGWGSHQAEAAQLRQFYVAAQGILWNY-HPEPTDP-SLN
S-IPSFKKIVYREYEQYFKKEKPRS

PF07732 // ENSGT00910000143988_0_Domain_0 (86, 201)

SN--SGLLGPTLYAEVGDVIKVHFRNKADKPLSIH
PQGIKYSKFSEGASYADHTFPAERKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYY
SYENLTQDFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSRSQ-------
---------------SPSLMYTINGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHF
NGQVLEQNQHKVSTVTLVSATSTTANMTMSPEGRWIVSSL--IPKHY-QAG--MQAYIDI
KNCPKKTRSPKTLTREQRRYMKRWEYFIAAE-----------------------------
---EVIWNYAPVIPANMDKIYR-------SQHLDNFSNQIGKHYKKVIYRQYEEETFTKR
TDNP-SIKQS

PF07732 // ENSGT00910000143988_0_Domain_3 (491, 567)

GILGPVIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDGINS
SSTSGS-HTTIRPVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDQRGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFY
ESNIMS-----TIN-------------------------------------G--------
--------YVPES------ISTLG-FCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNPKR
RNLRLRFRDVKCNRDYDNEDSYE--IYEPPA----PT--------------SMTTRR-IH
DSLENEFGIDNEDDDYQYLLASSLGIRSFKNSSLNPEENE-FNLTALALENSS--EFISP
STDRVVDSNS--SRILSK---------------------IINNNLKDFQRTLPGSGATVA
GTLLRNLIGLDENFVLNSSTE---HRSSSYHENDM-----------ENP-QSNITMVYLL
PL--GPKGSGNREQDKPKTIKTGRPHMM-----------------KHRFSWMKAPAGKTG
RHSNPKNS------------------YSGMKSEEDIPSELIPLKQKITSKFLNRRWRVAS
EKGSYEIIAANG--EDT-DVDKLTNSPQNQNITVPRG-EST--SHTNTTRKPSDLPTFSG
VGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSP-----------------
-----------------------------------------------------------R
GFDPLRGHNHSPFPDRRLLNHSLLLHKSNETA-----LSPDLNQTSPSM-STDR--SLPD
YNQYSKNDT-EQMSSSLDLYQSVPAE-----EHSPTFPAQDPDQTHSTTDPSY-------
-------RSSPPELSQG-LDYD-LS-HDFY--PDDIGL--------------TSFFP-DQ
SQKS---------------------SFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQ
LLLSPEDNQ--KTSSPDLGQVPLSPDDNQ-------------------------------
------------------------------------------------------------
-KTSSPDLGQV-SLSPDDNQKT--SSPDLG-QVPLSLD-DNQKTTSPD--LGQVPLSPDD
NQMI---TSPDLGQVPLSSDN-QKTSS--PDLGQVPLFPE-DNQ-NY----------FLD
LSQVPLSSDQNQETSSTD--LLTLS---------PDFGQ--TVLSPDLDQLPLP-SDN--
S----------QVTVSPDLSLLTLSPD--FNEIILAPDLGQVTLSPDLI--QTNPALNHG
HKASSADP-DQA-------------SYPPDSGQA----SSLPELNRTLP-------HP--
-----DLTH-IPPPSPSPTLNNTSLSRKFNPLVVV-GLSRV-DGDDVEIVPSEEP-ERID
E---D-YA-EDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYL-RGH--GGHKKFYYIAAE
EITWNYAEFAQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------HEDTG--HTPKDTTYKKVVF-RKYLDSTFTSRDPR
AEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDESPEW
FQEDDAVQPNSSYTYVWHATKRSGPENPGSACRAWAYYS-AVNVERDIHSGLIGPLLICR
KGTLHMERNLPMDMREFVLLFMVFDEKKSWYYEKS---KGSRRIESPEEK------NAHK
FYAINGMIYNLPGLRMYEQEWVRLHLLNMGGSRDIHVVHFHGQTLLDNRTKQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTEVGENQVAGMQTPFLIIDKECKMPMGLSTGVISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLT-YWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAK
HYLKSCFTTEFQVAYSSDQTNWQIFRGKSGKSVMYFTGNSDGSTIKE-NRLDPPIVARYI
RIHPTKSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGLEDGRIQDK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYVKSYSI
QYSDQGVAWKPYRQKS-SMVDKIFEGNSNTKGHMKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----

---------------------ADWGVHAGPVRGLRQFYVAAQGVTWTY-RPEPPDP-SLN
PFIPSFKKIVYREYEPHFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVYFKNKADKPISIH
PQGIKYSKFSEGASYTDHTSPLEKMDDAVAPGQEYTYEWVISEDSGPTQDDPPCLTHIYY
SYENLTEDFNSGLIGPLLICKKGTLTEDGTQKMYDKQHVLLFAVFDESKSWNP-------
---------------SPSLMYTVNGYVNKTMPALTVCAYDHISWHLIGMSSEPELFSIHF
NGQVLEQKHHKVSTITLVSATATTANMTASPEGKWTISSL--IPRQF-QAG--MQAHIDI
TNCPKKTRTTTKLTREQRRYIKRWEYFIAAE-----------------------------
---EMMWDYAPIIPTTMDKLYR-------SLHLDNFSNQIGKIYKKVVYKQYQDESFTKR
MDNT-KINENGILGPIIRAQVRDTLKIVFKNS-ASRPYSIYPHGVTFSL----YEDDVNS
SSTSGN-HTMIRAVQPGETYTYKWNILESDEPTDSDAQCLTRPYYSDVDVTRDIASGLIG
LLLICKSRSLDMRGIQRAADIEQQVVFAVFDENKSWYIEDNIHKFCENPDMVKRDDPKFY
QSNIMS-----TIN-------------------------------------G--------
--------YVPQS------IPVLG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWVLTTMNSSPRN
KGLQLRFRDVKCMRDD-DEDSYE--IYEPLS-----P-------------TAMAVRK-IY
PPSENEEEETDPDDDYQDILASSLGIRSFRNSSLGQKEDE-LNLTALALENSS--ELISP
STDASISSNSSS----SS---------------------STVSNLTEPQKTLPHAGASKA
GHLLGHLSGLDKNPVVNSSTA---EYSSPYYEDQI-----------EDPLQSDVTEISLL
----DEKGFRDAEYVKHKAYRAKRNQLA-----------------NHRFSWMILPAHETG
RHSNQDDT------------------SSKMGPLEDLPSNLLLLKQKNPSKILEGKWHVAS
EKGGYKITQDTN--E---NMDELLNSPHN--VSRTWR-ESI--P-ENNPGKQSDHPKFSG
VRHKSLQVRQHGENSGLKKRPFLIRTRKKKKEPKLAHHIPLSV-----------------
-----------------------------------------------------------R
GIYPLRGADYIAFSDRK-LNHSLLLLKSNETS-----VPTDFNQTSPSI-NLVQIGSLPN
HNLSLPNDT-SQASSPPDFYQTVPPE-----EHYQTSPIQDTDQVHSTTDPSH-------
-------RSSPPELSQM-LKHE-LS-HELY--PVDIG----------------------L
SEPS---------------------SSSSQGQMT----------PSSDLSQIITSPGFGQ
IPLSPDL-----------------------------------------------------
-----------------------------------------SHKSPSPYLSQMPLSP---
------------------------------------------------------------
-------------------ELGETSLS--PDFSQM-TSSD-LSQ-T---------SLSSD
LRQMTSSPDLS---------QMPLSPELGEAKL---------------------------
---------------SPNLSQMTHSQD--LNQIPYSPGLSQVTISPDIS--ETTLPPNFR
QTSHPSDL-DQA-------------SYPCNSSQL----LPLSEFNQT-S-------YP--
-----DLVHMP-SPLPSPKLNDTFISNEFNPLVVV-GLSGD-YGDFTEITPRQKD-QISE
E---D-YA-EIEYVAYNDPYQTDRRTDINSSRNPDNIAAWYL-RSN--KGNRKYYYIAAE
EIFWDYAEFAQS---ETD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDSD--DIRKDTTYKKVVF-RKYLDSTFTKRDPR
GEYEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPIIRAEVDDVIQVRFKN-LASRPYSLHAHGLAYEKSSEGKTYEDDSPEW
FKDDNAVQPNKSYTYVWHATDQSGPENPGSACRAWAYYS-AVNPEKDIHSGLIGPLLICR
KGTLHKQSNIPVDMREFVLLFMVFDEKKSWYYGKS---ERTWKLESSEVK------NSHE
FHAINGKIYSLPGLRMYEQEWVRLHLLNTGGSRDIHVVYFHGQTLLENGTQQH-QLGVWP
LLPGSFKTLEMKASKAGWWLLDTEVGENQRAGMQTPFLIIDKDCKMPMGLSTGIISDSQ

PF00754 // ENSGT00910000143988_0_Domain_66 (3060, 3197)

M
KASEYLR-YWEPKLARLNNAGSYNAWSVEKNALETASKPWIQVDMQREVVITGIQTQGAK
HYLKSCYTTEFYVAYSSDRTSWQIFKGNSTKQVMYFDGNSDASTIKE-NQFDPPIVARYI
RISPTRSYNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMENGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITAFSFKKSWWG---DYW
EPSCARLNAQG-RVNAWQPKANNHQQWLQIDLLKIKKITAIVTQGCKSLSSEMYVKSYTI
HYSDQGMEWKPYRQKS-SMMEKVFEGNSNVKGHVKNFLNPPIISRFIRII-----PKTWN
QSIALRLELYGCDIY---------------------------------------------
-----

MLPGCPHLWVLLVLGTS---WAGWGSQGTEAARIRQFYVAAQAISWSY-RPELTNL-SLN
TSGTSFKKIVYREYEAYFKKEKPQSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 200)

LLGPTLYAEVGDIMKVHFKNKADKPLSIH
PQGIKYSKFSEGASYPDHTFPVEKMDDAVAPGQEYTYEWTISEDSGPTHDDPPCLTHIYY
SYDDLIQDFNSGLIGPLLICKKGTLAEDGTQKLFDRQHVLLFAVFDESKSWSQ-------
---------------SSSLMYTVNGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHF
NGQVLEQNHHKLSAITLVSATSTTANMTVSSEGRWIISSF--IPKHF-QAG--MQAYLDI
KNCPKKTRSPKKLTRDQRRHIKRWEYFIAAE-----------------------------
---EVIWDYAPIIPANMDKKYR-------SLHLDNFSNQIGKHYKKVVYKQYQDENFTKR
MDNP-NIKEDGILGPIIRAQVRDTLKIVFKNS-ASRPYSIYPHGVTLSP----YEVEVNS
SSSSSGNKTVTRAVQPGETYIYKWNILEFDEPTENDAQCLTRPYYSDVDITRDIASGLIG
LLLICKSRSLDKRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFY
ASNIMS-----TIN-------------------------------------G--------
--------YVPES------IPILG-FCFDDTVQWHFCSVGNQDDILTIHFTGHSFIYGKR
HEDTLTLFPMRGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTVNSGPRS
KNLRLRFRDVKCNRDD-DDDSYE--IYQPPT-----S-------------SPIDTRK-MR
DSSENRDEEYDAEYDYQNSLASSLGIRSFRNSSLNQEEEE-LNLTALALEGSS--EVISA
STGAALGSNSSSPRNISR---------------------LMVDNLTGPQKTFPHSGSAGA
GSPLRHHGGLDNDSVLNSSTK----ESSPYSEDPI-----------EDPSQSDITGIHLL
PL--EAEQSRSQEHAEHKGSKVQRDRAA-----------------KHMFSWMELPTHKLE
KHSNQNNA-----------------SPSRMEPWENIPSALLLLKQKDPSKILNGKWHVAS
EKGNYEIIQDAD--EDV-APKKMLNGSQG--ASRAWE-EHT--PFTNKPRKHSGH-TFPG
FKHTSLRAEQGGGNRRPKKSPFSIKTRKKKKEEKLVHYVPLSP-----------------
-----------------------------------------------------------R
SFRPLTGET-----DTR-LEHSLFPHKYKDTS-----LPTDLNQTSPSV-NVDMIASLLD
HNQNPPNGP-GQTSSPPDLYQMVSPE-----EHHQTFPTQNPDQMYLTTVPSH-------
-------RSSPLQLTQM-PHYD-IS-FESF--PTESNQ-M-SPSLER-EIGQTTISP-DL
SQSA---------------------SSLDIGQ----------VPLSPDLDQGTSFPDLSQ
MPLSPDLD----------------------------------------------------
------------------------------------------QGTSFPDLGQMPLSPDLD
-------------------QGT--SFPD--------------------------------
-----------LSQMPPSPDLDQGTSF--PDLNQMPPSPN-LDQ----------------
------------------------------ETSSPDLGQ--MPSSPDLGQMPLS-PDL--
D----------QGTSFPDLGQMPLSPD--LDQGTFFPDLGQVTLSPNIS--PTIL----S
TPSSLPDI-DQT-------------SYPSESGQP----LPFPESGQTVV-------YP--
-----DLSHMP-SPSSAPILNDTF--KEVNPLVVV-GVSGD-DGDYIEIIPRQEV-QSEE
D---D-SS-EIDYVSYDDPYKTDLRTDINSSRNPDSIAAWYLLRSN--NGNRRNYYIAAE
EISWDYSKFAQRYGDDMH------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NEDAD--DIPKATVYKKVVF-RKYLDSTFTRRDPQ
GENEDHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2878)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAIQPNCSYTYVWHATQRSGPESPGSACRAWTYYS-AVNSEKDIHSGLIGPLLVCR
KGTLHKASNMPVDRREFILLFMVFNEKKSWYYEKKS--KTSWRP-SSEVK------NPYE
FHAINGMIYSLPGLRMYEQEWVRLHLLNMGGSKDIHVVHFHGQTLLENGTQQH-QLGVWP
LLPGSFNTVEMKASKPGWWLLDTEVGENQRLGMQTPFLIIDKECKQPLGLSTGAIADS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLG-YWEPRLARLNNGGSYNAWSIEKTTVESAWKTWIQVDMQREVVITGIQTQGAK
HYLKSCYITEFCVAYSSDQTNWKIFKGNSTRNVMYFNGNSDASTTKE-NLFDPPIVARYI
RISPIRSYNRPALRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVNG--CSAPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSLARLNAQG-RVNAWQAKANNNIQWLQIDLLKIKKITAIATQGCKSLSSEMFVRSYTI
HYSDKGVDWKAYRQKS-STADKIFEGNSNTKGQVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDVY---------------------------------------------
-----

----------------------------------------------------------LN
TSGISFKKIVYREYEAYFKKEKPRSSI-SXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXASYQDHTFPEEKLDDAVAPGHEYTYEWSISEDSGPTHDDPPCLTHIYY
SFENLIQDFNSGLVGPLLLCKKGALTKDGTQKMFDRQQVLMFAVFDESKSWIP-------
---------------SSSLMYTVNGYVNGTLPDITVCAYDQISWHLIGMSSAPELFSIHF
NGQVLEQNHHKVSAIVLVSATSTTANMTVSPEGRWSISSL--IPRHV-QGKQTPPAYMDI
KNCPKKTRSPKKLTLSQRRHMKRWEYFIAAE-----------------------------
---EVIWDYAPVIPTNMDKIYR-------SLHLDNYSNQIGKYYKKVVYKQYQDESFTKR
VENP-NM-HDGILGPIIRAQVRDTLKIVFKNM-ASRPYSIYPHGVTFSP----YEDEANS
SSTSGQVIAMIRAVQPGETYTYKWNIIDSDEPTENDAQCLTRPYYSDVDITRDIASGLIG
ILLICKSRSLDKRGIQRTADVEQQMVFAVFDENKSWYLEDNINKFCENPDEVKHEDPKFY
ESNIMSNLTLSAIN-------------------------------------G--------
--------YIPES------IRALG-FCFDDTVQWHFCSVGTQDDILTIHFTGHSFVYGKR
HEDTLVLFPMHGESVTVT----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTTSSSPRS
KNLRVKFRDVKCIRND-YEDSYEI-LYEPPP----PE----T--------TTKGTRK-VH
DFPENRNEE-EEDEDYQNSLASALGIRSFRNVSLTQKEDE-LNLTALALENSP--ELMSP
SADTAISSNSSSPSNIRS---------------------LIDDGPSEPQETLLPPGTTNT
SPLLRHPANLDKSSSLNSPTA---EHAILYSEASL-----------EDSLQSQVTEIHLL
PT--GAKGFRSHRHAKYNIWKAGRDTAA-----------------KLEGPQKEALAPKHG
RHLRQDDD-----------------SPSRMESWEDLPSNPFLLKLKKAANILNGQRHPAS
EKGNYKIIRATD--EAI-TVNMLLDSPQN--DSRTWE-DST--PLTNKHRKHRGDSRFSR
VTHNPLQVRHEGEHSRLKKTAFHIRTRKKKKEDKLTPHVLGFP-----------------
-----------------------------------------------------------G
GFRPLTREADTTFSDQN-----LLLHKSNETS-----LLTDIHQTVPSI-NPSLMDSFPD
YNPNILSNDTGQPGSLAATS----------------------------------------
-----------QTVLHM-ADYD-LS-YESYL--NDGGP-I-VPFREL-EG----------
------------------------------GQ----------MTASPDIGQPPLSSDLSS
RTHSPNDF------SSDFHQTALFPDLSQMTVPPK-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------PSETSLPAALREATLSPELS--QTTISPNYN
QTLPSPDR-NQT-------------AYPSESTQL----QPSLERGQISP-------ST--
-----DLGQTS-SPPAPSAFNDTLISSQFNPPLIV-RLSRD-DGDYIEIIPRQEMLEISE
D---D-IV-QMDYVHYDDRYRTDMRTDVNSSRNPDNIAAWYL-RXX--XXXXXXXXXXXX
XXSWDYSQFAQR---XXXX-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXXX--XXXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVNPEKDIHSGLIGPLLICQ
KGALHRESNSPLDMREFVFLFMAFDEKKSWYYEKSP--KRSWPPESSEVK------HSHE
FQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXXXSFKTLEMKASKPGWWLLDTEVGENQRAGMQTPFLIIDRECKMPMGLSTGIISDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEHLG-YWEPRLARLNHGGSYNAWSIEKLSREPGSSPWIQVDMQREVMLTGIQTQGAK
HYLKSYYTTEFFVAYSSDSTHWQIFKGNSTKSLMXXXXXXXXXXXXXXXXXXXXXXXXXN
RISPIQGLNRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIESK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITSSSFKKSWWG---DYW
EPSNARLNAQG-RVNAWQAQANNNKQWLQIDLLKVKKITAIVTQGSTSLSSEMYVESYAI
HYSDQGVEWKPYRQNF-FMVDQIFKGNSNPKGHVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDFY---------------------------------------------
-----

MARGWPGLWVLVVLCSS---WPPGRQHRAEAAGLRDFYVAAQAVDWTY-RPPQPEALRFK
RSESVFKKIVYREYDADFKKEKPRSSI--SG

PF07732 // ENSGT00910000143988_0_Domain_0 (92, 202)

LLGPTLYAEVGDTLNIHFKNMVNKSLSIH
PRGIAYSKRSEGALYADWTTPFEKMDDAVLPGQQFTYVWKITEGVGPTEADPPCLTQIYY
SHENVIQDFNSGLVGALLICKKAPASRPRSENN-IKQQVLMFAVFDESKSWQP-------
---------------RSALMYTVNGYANGTLPDIQACALDHISWHLIGMSSGPELFSLHF
SGQVLEHNGHKLSTFNLVGATSFTANMTVSHEGWWMISSL--VPLHM-EAG--MHGYLNI
KSCQKQTRSNKKISRDQRRQIKDWEYFIAAE-----------------------------
---EVMWDYAPVIPGNMDKKYK-------SQHLDNFSNQIGKIYKKVVYKEYQDASFTKR
RESN-KISETGILGPIIRAQVRDTIKVVFKNL-ASRPYSIYPHGVSLSK----TIHCLGR
PLG-GGNSTLSRAVQPGEIYTYQWTILESDEPSEKDVQCVTRPYYSAVDVSRDIASGLIG
LLLICKGRSLDKRGMQMKADIEQQAVFAVFDENKSWYIEDNINKFCQDPTSVKRDDPRFY
ESNVMST-----IN-------------------------------------G--------
--------FVPES------LPILG-FCFDDVVQWNFCSIGSQNTIVSIHFTGHSFWYEGR
PEDVLTLFPMSGKSVTVP----------MDNVVNYVLEVHRT-PLHENESS---------
---------HIYRVL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SARLCCS----------------------------------------------
----------------------DGGCTEV-------------------------------
-----------------------------------FRNPSFLHGFPGTWMVTSMGSAKRD
ESIGLKFRDVKCIRDYSNYDYEEIVFD-----------SIKKTLKSDFT-DVPS-----P
DGYLEDPLANGDSFDYQDALALELGLRSFKNKAVAPEEELLLNLTALALNDSL--GPSTQ
SAE---EANASDPWP----SKIESFL--T-------------DDPSEPQTTSPHPAIPTA
GNLPEHLPGAGGHSIVQRSVA----ENSVLPSDQLEGTPASDVKEMGLFPDGEGMSQKV-
-A-----EE--------------------------------------------EDGQA--
R------------------------ATSQVFDNLTLAEK--------------GGDGSER
RHIPPSKIASGRSPEGVPSEDSLSLSGVTP------G----------TRGQPPGH-QFF-
-------------SGRKDPSKMPIKNWNLGSEKEGSENIKRTDEVGSFNK-------LPK
GPWFT-SQSWRERTHL-------ASRQGRP------------------------------
--VSH---------------------------QKFAEHRQKIKRARPKFLNQG-------
--ADGEST--------------------PI-RPAMTFIKTRRKKIDKS-ASHF-------
-------AMSPRGFNPL-HGSKP---NSSF----SPGPANHTSSLNESDWTSP-------
---------------------------P-------------------------PVVSPTS
PLLTVNQSLPPLSLDHTSS--------------------------------------SLD
PGH------------------ELLPPSLDQNIS--LPD------------PDP-------
--TYP---------------------------------------------APAFN-QPSP
PSPRFNETSSP-LGPRL-------------------------------------------
----------------PDLYPTSTL-LYS-----------------QWSSHP--------
----------------SDL------QT-----VTGPPDHSRTTQSSSSDQTSPTWDPERD
GHQRLP-----T-------------PYSERTTSPPDQVSELPDLARLLPPAPTQML----
----ANLSLNETTLSLPAEPGDALTPKQMKPEIIL-GLTKE-NGDYIEYVPGPEIQ-NSD
E---D--LAMIQYVAYDNPYENDFRANPYTLRNPDTIASWYI-RSY--NGNRKYYYIAAE
EVFWDYSGLRKSETKTGHP-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------GSIPGDTVYKKVIF-RSYLDSTFTTPDPR
GEDEEHLG

PF07732 // ENSGT00910000143988_0_Domain_61 (2769, 2844)

ILGPVIRAEVDDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKSYEDESPEW
FKNDSAVQPNSSYTYVWHATEKSGPENKGLDCRIWAYYS-AVNSEKDIQSGLIGPLLICR
KGTLHKKSNQPVDTREFVLLFMIFDEEKSWYFDKKS--KKTRSEQ-----------TSHK
FHAINGIVSYLPGLRMYEREVVHWHLLNMGGSQDLHVVHFHGQTLLERGKQ-DHRLGVYP
LLPGSFRTLQMTAEKPGFWLLDTSVGDSQKGGMQAIFHIIDKGCKMPMGLSTGTILDS

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
SASEYHS-NWEPKLARLNKIGSYNAWSTEKST---SDNPWIQIDLQREVVLTGIQTQGAK
HYLKSYFTIEFYLTYSTDKRRWNTFKGKSTLKQQSFEGNSDASTIKE-NKIDPPIVAKYI
RIYPTLYNRRPTLRLE

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LLGCEVLG--CSTPLGMESKKIAKA

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKTSWWG---TAW
EPSCARLNEQG-RVNAWQAKSNNNNQWLQVDLLQTKKITSIATQGAKSLNRDMYVETYTV
LYSDQGSQWKPYTENL-SSMPKIFIGNVNTNGLVRNYFNPPIFSRFIRII-----PKSWN
DSIALRLELFGCDIY---------------------------------------------
-----

MSPGCPGLWVLVILGTS------WGSLGAGAAQLRQFYVAAQTISWSY-RPEPMDP-SMN
HSATYFKKIVYREYEAYFQKEKAQPKT--SG

PF07732 // ENSGT00910000143988_0_Domain_1 (92, 120)

LLGPTLYAEVGDMMKIHFKNKADKALSIH
PQGIKYSKFSEGASYSDHTFPVEKMDDAVAPGQEYTYTWSISEDSGPTQDDPPCLTHIYY
SHENLTQDFNSGLIGPLLICKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------
---------------XXXXXXXXXXXXXXXXXXIVVCAHDHISWHLIGMSSGPELFSIHF
SGQVLEQNHHKVSAITLVSATSSTANMTVSPEGKWIISSL--IPKHQ-GIP--PTXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------------------
---XXXXXXXXXXXXXXXXKYR-------ALHLDNFSNQIGKHYKKVVYKQYQDESFTKR
MDNS-DVKIDGILGPVIRAQVRDTLKXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX-XXXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXRTADIEQQAVFAVFDENKSWYIEDNINKFCENPEKVNRDDPKFY
ESNIMSNVTLPAIN-------------------------------------G--------
--------YVPES------IPTLG-FCYDDTVQWHFCSVGTQDDVLTIHLTGHSFIYGKR
HEDTLTLFPMRGESVTVS----------MDNVG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------TWMLTTMNSNQRN
KKMRLKFRDVKCNRED-YEDSYEI-TYELPP----ST--------------SMTTRK-MR
DSLESKHEENNDDYDYQNNLASVLGIRSFKNSSLNQEEDE-FNLTAIALEDNS--EFIHP
-----VGSNSSFPRIMSR---------------------LTANNFTEPQKILISLEAATT
GSPLEN-MDLEKNSVLNSSPA---EHSNPYSEDPI-----------EDLLQSDVTGIHLL
PR--GAEGISSQEHAKHKGFKALRNRVA-----------------KHRFSTMESSVHESR
RHRSQSNT-----------------SPSR-KSWENLPSGLLLLKQKNPLNISGGVWHLAS
EKGSYEVIQDAD--EDT-GTSKVLNSPPN--ASETWG-ESI--PSTNMHRALSDNPKRFG
IKHKSLRIRQNGRNGGLKKNTFFIRTRKKKREGKFPHHVLLSP-----------------
-----------------------------------------------------------R
SFHLPGGNTNTTFSDKT-LVHSLPFHKSNQTS-----LPIGLNQTFTSM-NFDLIASLPN
HNQNSPNET-NQTSSPLDFNPTKSLE-----EHTQTSLIQSSNQTYSTRESSH-------
-------RSSPPELAQM-LDND-PR-NKTF--PADIGQ-M-FPSLEP-EVWLTTMSP-DL
RT-I--------------------

PF06049 // ENSGT00910000143988_0_Domain_12 (1945, 1963)

-LSPELNQ----------KDLSKDSGQI

PF06049 // ENSGT00910000143988_0_Domain_16 (1973, 1981)

PLSPDLSQ

ENSGT00910000143988_0_Linker_16_17 (1981, 1982)

T

PF06049 // ENSGT00910000143988_0_Domain_17 (1982, 2001)

ILSP-----------DFSQ

ENSGT00910000143988_0_Linker_17_20 (2001, 2002)

E

PF06049 // ENSGT00910000143988_0_Domain_20 (2002, 2028)

TLPLDLSQ------------------

ENSGT00910000143988_0_Linker_20_22 (2028, 2029)

E

PF06049 // ENSGT00910000143988_0_Domain_22 (2029, 2038)

TLSSDVSQ-NLS
PYFKHE

PF06049 // ENSGT00910000143988_0_Domain_24 (2047, 2055)

TLSPDFNQ

ENSGT00910000143988_0_Linker_24_25 (2055, 2056)

E

PF06049 // ENSGT00910000143988_0_Domain_25 (2056, 2064)

TFFPDLGQ

ENSGT00910000143988_0_Linker_25_27 (2064, 2065)

T

PF06049 // ENSGT00910000143988_0_Domain_27 (2065, 2073)

TLSPHISQ

ENSGT00910000143988_0_Linker_27_28 (2073, 2075)

E-

PF06049 // ENSGT00910000143988_0_Domain_28 (2075, 2084)

TFSP-DHRQ

ENSGT00910000143988_0_Linker_28_30 (2084, 2085)

T

PF06049 // ENSGT00910000143988_0_Domain_30 (2085, 2163)

TVSP------------
----------------------------------------------------------DL
SQET---LPIDV------------------------------------------------
-------------------IQMTISPDLSQ------------------------------
-------------------------------EENQFPNLSQTTLSAGVS--G

PF06049 // ENSGT00910000143988_0_Domain_56 (2333, 2342)

TTL-PELR
QT---SNL-DQI-------------SNISESSQP----LPLSEFGHT

PF06049 // ENSGT00910000143988_0_Domain_60 (2388, 2410)

LP-------LP--
-----DLDQMS-S----SATNNTFTSRDVNPLVVV-GLSKA-DGDYIEIIPREKE-KSSE
E---D-YV-VMDYVTYDDPYQTDFRTDINSSRNPDNIAAWYL-RSK--NGNRKNYFIAAE
EIYWDYSKFSQS---EMD------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------NDNMD--DVPEDTVYKKVVF-RKYLDISFTKRDPR
GEYEEHLGILGPVIRAEVGDVIQVRFKN-LASRPYSLHAHGLSYEKSSEGKTYEDDSPEW
FQEDNAIQPNSTYTYVWHATERSGPEVPGSACRAWAYYS-AVNPEKDINSGLIGPLVICQ
RGTLHKESNMPVDMREFVLLFMIFDEKKSWYYEKKP--QRSWRLPSSEGK------HSQE
FHXXXXXXXXXXXXXXXXXXXXRLHLLDTGSARDIHVVHFHGQILLENGTQQH-QLGVWP
LLPGSFKTLEMKASKPGWWLLDTQIGENYRAGMQTPFLIIDKEC-MPMGLSTGLITDP

PF00754 // ENSGT00910000143988_0_Domain_66 (3059, 3197)

QI
KASEYLN-YWKPNLARLNNGGSYNAWIAEKPSEEFDSKPWIQVDMQREVLLTGIQTQGAK
HYLKSYYTTEFYVAYSSDQTHWQIFKGNSTENVMYFVGNSDASSIKE-NQFDPPIMARYI
RISPTLSYNKPALRME

ENSGT00910000143988_0_Linker_66_68 (3197, 3222)

LQGCEVNG--CSTPLGMESGKIENK

PF00754 // ENSGT00910000143988_0_Domain_68 (3222, 3369)

QITASSFKKSWWG---DYW
EPSRARLNAQG-RVNAWQA--NNNKQWLQIDLLTVKKITAIITQGCKSLSSEMYVKSYTI
QYSYQGVEWKPYRHKS-SMVDKIFEGNINIKGQVKNFFNPPIISRFIRII-----PKTWN
QSIALRLELFGCDIY---------------------------------------------
-----