Query Results 

------------------------------------------------------------
----------------MNTGFSFSDF

PF13543 // ENSGT00900000140880_0_Domain_0 (87, 182)

LQAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADV--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------ATEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGCV-----------PSLL
WGIIRAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ISLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
--------------------------LQAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------SMRFDL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLQE--NTFNSVNISAFA--QAAPLPEAADGTRLD-SQPKADVLE---
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF00069 // ENSGT00900000140880_0_Domain_3 (793, 1678)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
----------------MNTGFSFLDF

PF13543 // ENSGT00900000140880_0_Domain_0 (87, 182)

LQAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
STQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADV--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------ATEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-AEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
-----------------------------------------------------------F
SFSLFLFSYP---PQKISGELT---LDALLEMNETKVKETMRHCGANADEVSRVHYALSC
LRKVTGLGPPGPTGGEPKEDSAWSPLDARRESGSGPPPDTLSPAGLTWTPGASQLGKG-T
GSQQPRSISVSALPT-SDAAPQGQGLGGYGEGLSDSYISLHHSGRLTPR-TPHSFITPPT
TPQLRRQNKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVPSIKF-----
---------------------------DL--HHGSPQ--TERRDIGLSVTHRFSTKSWLS
QICHVCQKSMMFGVKCKHCRLKCHNKCTKEVPVCRISFLP--LSKLRRTESVPSD-----
----------INNPVDR-------------STEPHF--------------GTLPKALTKK
EHP--------PAVNHLDSSSNPSSTTSSTPSSPAPFQS-SNPPSATTPPNPSPMAQRDS
RFNFPDAAHYIHHRQQFIFPAPPAD----H-------------IKK--------------
------YLQITKKKK-----ENSFYISTPS--QAPQVPDAAEETRV-NDQPKASM--T-E
DHETEVEEQE--------ASKSELEDD-EDELDDLPNSRKP---WKGMISRK-ASK-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1680)

VELGEPIGQGRWGKVYRGRWH-GEVAIRLLEIDGNNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNIFYDNGK-VVITDFGLFGISGVVQEGR---RENELKL
PHDWLCYLAPEIVREMTPGKDEDKLPFSRAADVY---AFG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------TVWYELQ----------------
------------------------------------------------------------
--ARDWPFQTQPA-----------------------------------------------
------------------------------------------------------------
----------EALIWQIG------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SGEGVKQVLAGISLGKEVSEILSACWAFDLQ--------ERPSFPLLME
MMEKLPKLNRRLSHPGHFWKSADINSSKVVSRFERFGMGIPESSNPKI------------

------------------------------------------------------------
--------------------------LQAKLVRYICKQRQCKLSVAPSERTLELNSYPRF
SDWLYIFSVRPELVQEIPRELT---LDALLEMNEAKVKETLRRCGASPEECGRLQHALAC
LRKVTGLG------GEHKEDSGWSSVDARRESGSGPPTDTLPPASLPWTPGSSQLGRGGS
STQGPRSVSVSALPASDSA------APGLSEGLSDTCLPLHASGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMRF-----
---------------------------DL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--PVTLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTS-NPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
HW---KCLLMAELK------TVGFNISAFP--QTAPPPDTADGDRP-DEQPGADVDTL-E
APGAEAEEPE--------AGRSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF00069 // ENSGT00900000140880_0_Domain_3 (793, 1678)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVFREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------T----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRILASINLGKEVSEILSACWAFDLQ--------GRPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINGSKVVPRFERFGLGVLESSNPKM------------

MD------RAAL-RGSAMGE-KKE---GGGA--DAAADGSARAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAASERTPELDSYPRF
SDWLYIFNVKPEVVQEISHNLT---LDTLLEMSEAEVKETLRHCRAGPEDCGRLQQALAC
LRKVTGLG------GEHKEEPSWSSADARRESGSGPPTDSLSPASSPWLPGSAPLGRVGN
SLQGPRSVSVSALPASDSA------APGLSEGLSDSCLPLHASGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMR------
--------------------------FDL--QHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCHVCQKNMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LT-LRRTESVPSD-----
----------INNPVDR-------------AAGPHF--------------GTLPA-LSXX
EHP--------PAINHLDSSSNPSSTASSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPX-XXXXXXXXXXXXXXXXXX----X------------------------------
--------XXXXXXXXXXXXXXXXXISAFP--QAVPLPDAANSVRP-EEPPQTDV--L-D
AHKAEAEEPE--------ASKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVFREER---REIQLKL
SHDWLCYLAPEIVREMVPQ-DEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GTKRLLASVSLGKEVSEILSACWAFDLH--------ERPSFSLLME
MLEKLPKLNRRLSHPGHFWKSADINSSKVVSRFERFGLGVLESSNPKM------------

-------------------------------------------LGLTSLTACMELKARAL
TSTVPAQQLPGRC---------VLTMHPA

PF13543 // ENSGT00900000140880_0_Domain_0 (90, 182)

RLVRYICKQRQCKLSVAPSDRTPELNSYPRF
RDWLDTFNVRPAVAQEILRELTGDQLDALLEMDEAKVKETLQRCGASTEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSSEARRESSSGPSVDTLSPATLPWPPGSSLLGRVGS
GAQGLRSVSVSALPASDSP------APGLSEGLSDTCIPLHASGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMNV---PN
PA---------------------SFLTDL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAVNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------GE---------SSA-
------CIG--------------------------PGLANFASVLP-DEQQKAEV--V-E
AQQAEAEESE--------AGKSEAEDD-EDELDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMRRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

MD------RAVR-RAAAMGE-KKE---GGGGGDAAAADGGAGAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSERTSELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEAKVKETLRRCGASPEECSRLQYALTC
LRKVTGLG------GEHKEDSGWSMSDARRESSSGPSTDSLSPASLPWPPGSSQLGRVAN
SAQGLRSVSVSALPSSDSP------TPGLSEGLSDTCVPLHASGRLTPR-ALHSFLTPPT
TPQLRRHSKLRPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSPM-------
--------------------------RDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SSGH
HW---KCLSIVGNLK-----EKTFNISTFA--QAAPLPDAADSTRL-DDQPKADV--L-E
VHEVEAEEPE--------AGKSEAEDDEEDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1681)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RAVL-RRAAMGE-KKEGKEGGGGGAAAATDRGSGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISISSLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQRQCKLSVAPGDRTPELNSYPRF
RDWLDTFSVRPEVAQEILRELTGDQLDALLEMDEAKTKEMLQRCGASAEECGRLQQALTC
LRKVTGLG------GEHKEDSGWGSCEARRESSSGPCVDSLSPATVPWPPGSSLLGRGGS
GAQGACD----------SP------APGLSVGVLDTCSLLHASGRLTPR-GPHSLITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPALTRSKSHESQLGNRIDEVSSMRW-----
---------------------------VW--P-VASP--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-SQRDS
RFNFPA-AYFIHHRQQFIFPGESSA-----------------------------------
-W---PTN--------SLASD--LPQEPLP--SPGSPDRACFILRL-DDQPKAEV--V-E
AHEVETEEPE--------AGKSEPEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_4 (793, 971)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EILSACWAFDLE--------ERPSFSLLMH
MLEKLPKLNRRLSHPGHFWKSADISSSKVVPRFERFGLGALESGNPKM------------

------------------------------------------------------------
---------------------------QAKLVRYICKQQQCKLSVAPGERTSELNSYPRF
SDWLCTFNVRPEVVQEILSELT---LDALLDMNEVKVKETLRRYGANAEECGRLQYALAC
LRKVTGLG-----GGEHKEDLGWSSLDARRESGSGPSADNLSPASLPWPPGSTPLGRMGS
STQGPRSVSVSALPTSDSP------IPGPCEGISDTCILLHTSGRLPPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------PMRFDL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLPQ--PRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VF---------GPGR
C-GL--CLLPSSPLR---AAPP-EDISAFP--QAVPSPDAAD-STRHDNQPKAD--VSEG
HEV-EAEEPE--------ASKSEAEDD-EDEVDDLPSSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFTLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RAAL-RAA-MGE-ED--------GGTGDADGGAGAAASRALQQCGQLQKLID
ISISSLRGLRTKCSASNDLTQQEIRTLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXEILSELT---LDALLDMDEAKVKETLRRCGASSEECGRLQQALTC
LRKVTGLG------GERREDSRWSPMDVRRESGSGPPPDTLSPASLPWAPGSSQLGRGAS
GAQGPRSISVSTLPTADSP------APGLSEGLSDTCIPLHASGRLTPR-TLHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMRL-----
---------------------------DL--SHGSPQ--MVRRDIGLPVTHXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXX-----
----------XXXXXXX-------------XXXXXX--------------XXXXXXXXXX
XXX--------XXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXACFIHHRQQFIFPVPPAG----H-------------LK---------------
-----------------------CLISAFP--PAAPPPETADSTRP-PDQPKADL--L-E
DHEAEAEEPE--------ASKSEAEDD-EDEVDDLPSSHRT---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_4 (792, 1038)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMDPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMMPGKDEDKLPFSKAADVY---AFGTIWYELQARDWPFKKQAAEA
MIWQVGSGEGMKRVLASVSLGKEVSXXXXXXXXXXXXXXXXXXXXXXX------------
------------------------------------XXXXXXXXXXXXXXXXXXXXXXIS
SSKVSPRFERLGLGVLEPSNPKM-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

------------------------------------------------------------
----------------MNTGFSFLDF

PF13543 // ENSGT00900000140880_0_Domain_0 (87, 182)

LQAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQMGRAGN
SAQGPRSVSVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-AEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RAAL-RAAAAAA-KKE---GGGGG----------AAAGRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSDRTAELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDVLLEMDEAKAKETLRRSGASAEECGRLQQALTC
LRKVTGLG------GEHKEDAGWSCVDARRGSGSGPSVDTLSPASLPWTPGNAQLGRVGN
SAQGPRSVSVSALPASDSP------APGLSEGFSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPGFPTLTRSKSHESQLGNRIDEVSPMSL---PN
LA---------------------SAPADL--QHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFPGESSP----S-------------CTVP---------PAGH
RW---HCLLIAEKP-------------------------------------------S-A
PFSFQAEEPE--------GGKSEAEDD-EDELDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPQLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVFREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVKRILASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADMNSSKGVPRFERFGLGALESSNAKM------------

MD------RAAL-RAVAMGE-KKE---GGGGGAAAAADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDESKAKEILQRWGANAEECSRLQQALTC
LRKVTRLG------GDHKEDSGWNSADTQRESSSGPSVDMLSP-----------LGRVGA
STQAPRSVSVSALPASDSP------VPGLSEGLSDTCIPLHTGGWLNPR-TLHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVSPMNLLGSSN
LG---------------------SFPTDL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------ASEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFNFPA-ASFIHHRQQFIFPGESSA----W-------------VHSL---------PR--
------------------------AGHPGP--AQDLLDKACFTPRL-EDQPKADV--L-G
VHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINNSKVMPRFERFALGALEPSNPKM------------

------------------------------------------------------------
----------------------------AKLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLTC
LRKVTDLR------GEHREDSTWSASDGRRESGSGPHVDTLSPASLAWPAGSSQLGRPVG
GAQGPRSVSVSALPVADSP------LLGLGEGVSDSCVSLHAGGRLTPR-ALHHFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPGFPTLTRSKSHESQLGNRIDEVSPMXX-----
---------------------------XL--PQ-GSQ--MVRRDIGLSVMHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCXXXXXXXXXXX------------------------X-----
----------XXXXXXX-------------XXEPHF--------------GTLPKALTKK
XXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXX-ATFIHHRQQFIFP-------------------------AP---------SAGS
H-W--KCLLGAENLKE--KT---CNISAFP--SGAPCPDAVADGTRPDSQMQAD--MLED
QDVEPDEEPE--------TGKSEAEDD-EDEVDDLPSSRRA---WRGPISR-KASQ-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKX
XXX-----XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSRAADVY---AFGTVWYELQARDWPFKIQPAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFELQ--------ERPSFTMLMD
MLEKLPKLNRRLSHPGHFWKSA--------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MTPGKDEDQL

PF07714 // ENSGT00900000140880_0_Domain_3 (986, 1681)

PFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------GRPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSAE-------------------------------------

MD------RAAL-RAAAMG--EKKEGGG-GGAA-AAADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERPSELNSYPRF
SDWLYTFNVRPEAVQEILRELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHREDAGWSSLDARRESGSGPSADTLSPASLPWPPGSAQLGRMGS
GAQGPRSISVSALPASDCP------NPSPGEGLADPCISLHASGRLTPR-ALPSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMSLPNL--
----------------------ASFPADL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDG
RFNFPA-P------------------------------------------------SAGH
Y-WT--CLLRAESSKE--KTFN-KTISWIP--F-------------------HK--NCFA
HLL-CAEEPE--------ASKSEAEDD-EDEVDDLPSSLRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1680)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGIVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

XD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEARVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSSWSLLDARRESGSGPSTDTLSPASLPWPPGSSQLGRAGN
SAQGLRSISVSALPASDSP------TTSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNH--------------
----------------------------L--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPG-T---------TSP-------------------------VP---------SAGC
CW---KCLLIAEI-----------------------------------TEPRSSAHACSS
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNSKM------------

MD------RAAL-RAAAMGE-KKE---GGGGGAAAAADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVTPSDRTAELNSYPRF
TDWLYIFNVRPEVVQEIPQELT---LEALLEVDESKAKEMLRRWGASPEECSRLQQALTC
LRKVTGLG------GERKEDSGWSSADAQRESSSGPSVDMLNP-----------LGRVGA
STQGPRSISVSALPASDSP------VPGLSEGLSDTCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVSPMRY-----
--------------------------LYL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNRCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------ASEPHF--------------GTLPKALTKK
EHP--------PAT-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFNFP-------------------------------------------------------
------------------------DISA----QAAPPSSTADSTRP-DDQPKADV--L-G
VHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRH---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKISLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRNEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------E-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGALESSNPKM------------

MD------RAVL-R-AAMGE-KKE---GGGGGAAAAADGASGAAAGRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQRQCKLSVAPGDRTPELNSYPRF
SDWLDTFNVRPEVTQEILHKLKGDQLDALLEMDEAKVKETLQRCGASAEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSSDARRESSSGPSVDTLSL-----------LGRVGG
GAQGPRSVSVSALPASDSP------APGLSEGFSDTCIPLHTSGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMRF-----
---------------------------DL--SRGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--ITRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PVMNHLDSSSNPSSTTSSTPSSPAPFPASSHPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DISAFP--QAAPLPDGADNTRL-DDQPKAEV--L-E
AHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-TSQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVCEMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLGSVSLGKEVSEILSACWAFDLQ--------ERPSFSMLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MTPGKDEDQL

PF07714 // ENSGT00900000140880_0_Domain_3 (986, 1681)

PFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFTLLMD
MLEKLPKLNRRLSHPGHFWKSAE-------------------------------------

MD------RAAL-RAATMGE-KKE---GGGGGA--------GAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISLGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVPPSDRTPELNSYPRF
SDWLDTFNVRPEVAQEIPRGLT---LDALLEMNEAKMKETLRRCGASAEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSLDARRESSSGPCADALPP-----------LGRVGS
SGQGPRSISVSALPALDSP------APGLGEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMSLPNLT-
-----------------------SFPADL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNPLDSSSNPSSATSSTPSSPAPFPTPTNPSSATTPPNPSP-GQRDS
RFNFPV-PCSA-------------------------------------------------
---------------------------------QNLLNQACLTLRL-DDPPKADV--L-E
FPEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------G----------A------
----H----------L---------W--------R----------P----------H---
-------R----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRILASVSLGKEVTEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

MD------KTVL-RAAAMGE-KKE---GGGGGAAAAADGSPGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQRQCKLSVAPSDRTPELNSYPRF
RDWLDTFNVRPAVAQEILRELTGDQLDALLEMDEAKVKETLQRCGASTEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSSEARRESSSGPSVDTLSL-----------LGRVGS
GAQGLRSVSVSALPASDSP------APGLSEGLSDTCIPLHASGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMKF-----
---------------------------DL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAVNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFP-------------------------------------------------------
------------------------DISAFP--QAAPHPEAAENTRP-DEQQKAEV--M-E
AQQAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRWP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMRRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

MD------RA-VRRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQCGQLQKLID
ISISSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTSELNSYPRF
SDWLYTFNVRPEVVQEILQELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSGWSFLDARRESGSGPSMDTLSPAGLPWPAGSSQLGRLGS
SAQGPRSVSVSALPTSDSS------TPGPNEGFTDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------PLRFDL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLPI--SRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
NY---KCLLSAESLKG--K----TNISAFP--QAAPFPDAVANTRLD-DQPKANVL---E
DHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDRLPFSKAADVY---AFGXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------XXXXXXXXEILSACWAFDLQ--------ERPSITLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSGLPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-AEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

--------RAAL-RAAAMGE-KKE---GGGGGDAAAAEGGAGAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXX
XXXXXXXX------GEHKEDSGWSSLDARRESGSGLSTDTLSPASLPWPPGSSQLCRVGT
SAQ-PRSISVSALPASDSP------APGLSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPGFPTLTRSKSHESQLGNRIDEVSPMRF-----
---------------------------DL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCXXXXXXXXXXXXXXXXXXXXXX-XXXXX-XXXXXXX-----
----------XXXXXXX-------------XXXXXX--------------XXXXXXXXXX
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPX-XXXXXXXXXXXXXXXXXX----X------------------------------
--------XXXXXXXXXXXXXXXXXISAFP--QAAPLPDAADNTRL-DDQPKADV--L-E
VHEVEAEEPE--------PGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTXXXXXXXXXG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---A----------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------F---
-------G-----------------------------TIWYEL-----------------
----------------------Q-------------------------------------
--ARDWPFKNQ-----P-------------------------------------------
--------------------A----------E----------------------------
-----------ALIWQI-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------GSEGMKRVLXXXXXXXXXXEILSACWAPDPQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MTPGKDEDQLP

PF07714 // ENSGT00900000140880_0_Domain_3 (987, 1682)

FS--------------------------------
------------------------------------------------------------
---------------------R----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------L----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------V----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKWVLASVSLGKEVSKILSPCWALDLQ--------KRPSFSLLMH
MLEKLPKLNWWLSHPGHFWKSAE-------------------------------------

MD------RAAL-RAAAMGE-KKE---GGGGGAAAAADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDESKAKEMLRRWGASAEECSRLQQALTC
LRKVTGLG------GEHKEDSGWSSAEAQRESSSGPSVDMLSP-----------LGRAGA
GTQGPRSVSVSALPASDSP------GPGLSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVSPMR------
--------------------------FDL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------ASEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DISACP--QAAPLSSTADSTRP-EDQPKADV--L-G
VQEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1682)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLME
MLEKLPKLNRRLSHPGHFWKSADINSSKIMPRFERFGLGALESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------TPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPSAE-------
---------------------------------ASRT--MVRRDIGLPVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPRECSALSPPPSGYGGLQGAF
TARQTHLETDMSRLVFGSGKHGPGPGSRGSTSAGSYGRIKRRSMQGSDSPCPPPLSLVLQ
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFPGESFACHGILVIPGFPILQLSSTRGAPQAASVLSHLLCCA
CWFHAGVTIFTPLGSDRTSYQVEFQVLCICSELSSWVREMGCGPRLPDFAQPPDCLSHSQ
DHEVEVSEGDPQALDGTLMLFPKAEDD-EDELDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_4 (792, 897)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLYSFVRDPKTSLDINKTRQIAQEIIK-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

MD------KAAV-RVAAMGE-KKE---GSGVGDTAAEDGGAGAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYIFNVRPEVVQXXXXXXXX---XXXXXXXXXKVKETVRRCRANNEECGRLQHAFTC
LRKVTGRG------GEHKEDSGWSPSDSRRESGSGPSMDTLLSASMTCPAGSSQLGRVGS
SAQGARSISVSALPTSDSL------TPGPSEGFSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPNRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSVRF-----
---------------------------DL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LPKLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------LAGH
YW---KRHLIAEXXXXXXXXX--------------XXXXXXXXXXL-NDRRKAEV--L-E
DHEAEXXXXX--------XXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXX-XXX-XXX
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF07714 // ENSGT00900000140880_0_Domain_3 (900, 1273)

G
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVQEER---RENQLKL
SHDWLCYLAPEIVREMTPGQNEDKLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D----------W----------P---------F----------K---------

PF00069 // ENSGT00900000140880_0_Domain_4 (900, 939)

GMGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFG

ENSGT00900000140880_0_Linker_4_5 (939, 1647)

LFGISGVVQEER---RENQLKLSHDWLCYLAPEIVREMTPGQNEDKLPFS-----------------------------------------------------------------------------------------------------------------K----------A---------A----------D----------V-----------------------------Y----------A----------F----------G----------T----------I---------W----------Y----------E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLG

PF07714 // ENSGT00900000140880_0_Domain_5 (1647, 1682)

KEVSEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------AAAGRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGDRTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LEALLEMDEAKAKETLGRWGASAEECGRLQQALTC
LRKVTGLG------GEHKEESGWNSSDAQRESGSGPSTDTLSPARS-------------A
QLKGPRSISVSALPASDSP------GPGLGEGPPDPCIPLHTSGRLTPR-ALHSLITPPA
TPQRRRRAELKPPRTPPPPSRKVFQLLPNLPTLTRSKSHESQLGNRIDEVSPMRS-----
--------------------------VYL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPP-VARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-QSLL-------------------------------------------------
-------------------------------------NKVCFLLRL-DDQPKAQV--L-E
VHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_4 (793, 866)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPRLAIITR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MTPGKDEDQL

PF07714 // ENSGT00900000140880_0_Domain_3 (986, 1681)

PFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSAEL------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EGKSG

PF02196 // ENSGT00900000140880_0_Domain_1 (272, 402)

GTVKVYL----------------------
----------------PNQQRTVVNVRPGMTVY---DSLDKALKVR--GLSQECCAV---
-----------YRLIQGSRKALTDWETDITPLVGEELMVEV

ENSGT00900000140880_0_Linker_1_2 (402, 410)

LADVPLSM

PF00130 // ENSGT00900000140880_0_Domain_2 (410, 458)

HNFVRKTHFTL
AFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTACVDMAKLPKPL---TPSPPGN-AGCV
MAPI-IFSSSFRSPWFPFHSMSPSRS------------------PRTQHPGSASFSFPGE
GQPLQRHRSTSTPNVHIDSTTGPVD----------------NSIIEVLPPQVSTGG----
---------------------------------------------------RLDSLTQGG
CTWVSTGGRLDSLTQGERCLIRPQQI-------YNWGPAISETVCLS-ETVS-----ASL
RSTAPPKVPSPLGV--NLLKPSLRRRRHERERRLRLTRRRKWLLWNGWVGKCNG---VLI
WLQV----LHATSRGSSR---ALGESQGFPWLLGDFPRRTCPI-----------------
----------------MSPLH--QLSAVC-------------------------------
----------------PLIPTTDIFLHEGLTVKIGDFGLATVKTRWSGSQ---QVEQPSG
SILWM-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------MMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFNFP-------------------------------------------------------
------------------------DISACP--QAAPLSSTADSTRL-DDQPKTDV--L-G
VPEAEAEEPE--------AGKSEAEDD-EDEIDDLPSSRRH---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVKRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADANSSKVMPRFERFGLGTLESSNPKM------------

------------------------------------------------------------
----------------MNTGFSFLDF

PF13543 // ENSGT00900000140880_0_Domain_0 (87, 182)

LQAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS-----SM--
----------------------RLPVALE--LHGKPS------HVPVSALCRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NAFN---ISAFA--HAAPLPEAADGTRAQ-ICC----PSLFF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
M

PF00069 // ENSGT00900000140880_0_Domain_4 (902, 1020)

GY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ISLGKEVTVS--SCPALGEGSGARGLAPGCPSFTHLRS
-------------GT-GKWMHVRLASVLLARRPVGFPGGGG-------------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSGLPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRLD-NQPKADVLE---
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
---------------------------Q

PF13543 // ENSGT00900000140880_0_Domain_0 (89, 182)

AKLVRYICKQQQCKLSVAPGERTPELNSYPRF
SDWLCTFSVRPAVVQEILSELT---LDALLDMNEVKVKETLRRYGANTEECGRLQYALAC
LRKVTGLG------GEHKEDSGWSSLDARRESGSGSSVDTPSPASLPWPPGSAQLGRMGS
GAQGPRSVSVSALPTSDSL------PPGPCEGLSDTCILLHTSGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------PMRFDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPQ--PRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------AP---------HAGD
K-IK--CRTICMALA---R-NV-AYISAFP--QAVPSPDAAD-STRLEHQPKTD--VLED
HEV-EAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFTLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADV--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------ATEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGCV-----------PSLL
WGIIRAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ISLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RAAP-RAAAMGE-EKEG------GRAGAADGGAGAEASRALQQCGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLETKLVRYICKQRQCRLSVAPDKRTSELNSYPRF
SDWLYTFNVRPEVVQXXXXXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXX
XXXXXXXXXXXXXXGEHKEHSGWGSLDARRETGSTPSLDTLSSASLHWPQGSSPMGRLGS
SAQGPRSVSVSALPASDSP------APGPSEGCSDTCLPLHASGRLTPR-ALHNFITPPT
TPQLRRHTKPKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSPMRF-----
---------------------------DL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_4 (458, 792)

FLP--LPRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFPVPSDG----F-------------H----------------
-K---KCLLSAESK------KNKFHISAFP--QP-PPDAADSNTRL-DDQTKVDV--L-E
DHEVEXXXXX--------XXXXXAEDD-EDELDDLPSSRR----TRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_4 (792, 1038)

VELGEPIGQGRW-RVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLYSFVRDPKISLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGMSGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLASVSLGKEVTXXXXXXXXXX---X-XX---XXXXXXXXXXXXXXX
XXXXXXX-------------XX----------X---------X---------XXXXXXIN
SSKVVPRFERFGLGVLESSNPKM-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------L--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX-----
----------XXXXXXX-------------XXXXXX--------------XXXXXXXXXX
XXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXX-AYFIHHRQQFIFP-------------------------AP---------SAGH
SW---KCLLMAESFRE--KVFN---ISAFP--QTALSPDAADSTRPD-DQPKTDVL---E
YHEVEXXXXX--------XXXXXXXXX-XXXXXXXXXXXXX---XXXXXXXX-XXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX

PF00069 // ENSGT00900000140880_0_Domain_3 (857, 1682)

XXXXXXXXXXXFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMAPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKKQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ASLGKEVSEILSACWAFDLQ--------ERPSFTVLMD
MLEKLPKLNRRLSHPGHFWKSA--------------------------------------

MDLLAQSVRADLQAAAAVSYFLAALQQGCTSQLSAPTTSQPGTFWSHPAI---SFHFALP
CLLLRWRGLL--------RLLPSVTSFEAKLLRYICKQWQCKLSVAPGERTSELDSYPRF
SDWLYTFNVRPEVVQEILRELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTRLG------GEHKEDSGWSSSDARRESGSGPPADTLSPASLSWPPGSSQLGRLGS
SAQGPRSVSVSALPASDSP------NPGPSEGLSDPFISLHTSGRLTPR-ALPSFITPPT
TPQLRRHSKLKPPRTPPPPSRKVFQLLPSLPTLTRSKSHESQLGNRIDEVSPMRL-----
---------------------------DH--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCRVCQKSMMFGVKCKHCRFKCHNKCTKEAPACRISFLPL--PKLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPASSNPSSATTPPNPSP-GQRDG
RFNFPA-AHFIHHRQQFIFP-------------------------AP---------SAGH
CW-K-----WLRCRKL--KENF-FNISAFP--QAAPFADGADSSR-LDDQPKAD--VSED
QEVEV----S--------DGDTQA-VD-GASLSSLPGSVR------GGVWERVGTQLCRA
WQVCWLMEPQQTDLLLPRGVTGFLSNIPGEQKKDRTCCNEDLVQANKQSE

PF00069 // ENSGT00900000140880_0_Domain_4 (831, 898)

LIFFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQITQEIIPL
VRGFGGPLLECCEIIGRECSTQGVVFGSPW-SLGTQCALDGASGESEEGGLRVRGPQVGL
RASWQQVPPTPPPHALL-VRAEQSCP--GAHAVWVGGLHRTVWYELQARDWPLKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGILESSNPKM------------

------------------------------------------------------------
----------------------------AKLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQEILCELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GDHKEDSGWSPSDARRESGSGPPADSLSPASLPWPPGSSQLGRVGS
GAQGPRSVSVSALPTSDSP------NPGPGEGLADACISLHTSGRLTPR-ALPSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMRF-----
---------------------------DL--LHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLPL--PRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------LAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPPSATTPPNPSP-GQRDG
RFNFPA-AYYMHPRQQFIFP-------------------------AP---------SAGS
C-W---C-LRAESLKE--EN---FNISAFP--QAAPFAEAD--SSRLENPPKAD--VSED
RE-VEAEEPE--------AGRSEVEDD-EDELDDLPSSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSVDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAVEA
LIWQVGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPLI-RSSSHPGHS-ESADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSVSVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-TEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
PHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
----------------MNTNFSFLRFP

PF13543 // ENSGT00900000140880_0_Domain_0 (88, 182)

QAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEARVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSSWSLLDARRESGSGPSTDTLSPASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TTSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNH--------------
----------------------------L--TRGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFPGDGRHLSVPY-------------HTVP---------SAGS
CW---KCLLIAESLKE--KPYNNGLPQGLL-------DKPCFTLRLN-DQPKADVLE---
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ISLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNSKM------------

------------------------------------------------LGRVGEGSGRRG
SPV

PF13543 // ENSGT00900000140880_0_Domain_0 (64, 182)

SPLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQRQCKLSVAPGDRTPELNSYPRF
SDWLDTFNVRPEVTQ-----LKGDQLDALLEMDEAKVKETLQRCGASAEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSSDARRESSSGPSVDTLSPASLAWPPGSSLLGRVGG
GAQGPRSVSVSALPASDSP------APGLSEGFSDTCIPLHTSGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMSL---PN
LA---------------------SLLTDL--SRGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--ITRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PVMNHLDSSSNPSSTTSSTPSSPAPFPASSHPSSATTPPNPSP-GQRDS
RFSFPA-AYFIHHRQQFIFPGEP---------------------------------SAGW
VW---LTEP-------------------LA--SPGPPDKAYFTLRL-DDQPKAEV--L-E
AHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-TSQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVCEMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLGSVSLGKEVSEILSACWAFDLQ--------ERPSFSMLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

MD------RAAL-RAAAMGE-KKE---GGDGGA--AADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ICIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQSKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQDLT---LDALLEMDEAKAKEMLRCWGASTEECSRLQQALTC
LRKVPSLG------GEPKVDSGWSSADA-RDSSSGPPVDMLSA-----------LGRAGA
STQGPRSISVSALPASDSP------VPGLSEGLSDSCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVAPMKFGKNNS
FSSLLPPGVKVKSMSPFRVDFSERTLAQL--PHGSPQ--LVRRDIGLPVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRITFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DISACP--QAAPLSSTADSTRL-NDQPKTDV--L-G
VHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM------------

------------------------------------------------------------
---------------------------QAKLLRYICKQWHCKLSVAPGERTSELDSYPRF
SDWLYTFNVRPDVVQEILRELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSGWSSSDARRESGSGPPADTLSPASLPWPPGSSQLGRLGS
SAQGPRSVSVSALPASDSP------NPGPGEGLSDTFISLHASGRLTPR-ALPSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------PMRFDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPL--PKLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPASSNPSSATTPPNPSP-GQRDG
RFNFPA-AYFIHHRQQFIFP-------------------------AP---------SAGR
C-WK--CLP-CRKLKE--NLFP-PDISAFP--QAAPFTDGAD-SSRLDDQPKAD--VLED
HEV-EAEEPE--------AGKSEAEDD-EDEVDDLPTSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF00069 // ENSGT00900000140880_0_Domain_3 (793, 1678)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ISLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGILESSNPKM------------

MD------RAAL-RAAAMGE-KKE---GGGGGA--AADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQQQSKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDEAKAKEMLWRWGASTEECSGLQQALTC
LRKVTGLG------GEHKMNSGWSSADA-RDSSLGPPMDMLSS-----------LGRAGA
STQGPRSISVSALPASDSP------VPGLSEGLSDSCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMKELSKPR
LSQ----CGDITPCSPFCL-----SRFEI--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRITFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DLSACS--QAAPLSSTADSTRL-DDQPKTDV--L-G
VHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM------------

------------------------------------------------------------
------------------------------------------------------------
----------PSSLQKIPQELT---LDALLEMNESKLKETLKRCGASAEECSRIHSTFAC
FRKVTSLE------GKKTPNSLWHPSPTSPNSGVGIQAESLDE-NGGWTSGAPHLCKAGS
GPQ-TRSVSVSAFPP----------AEAYPEGLPDALATQPPCGRLTPRTALGSPVTPPT
TPQLRRQFKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDESPAAK------
--------------------------FDI--PQGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LPKLRRTESVPSD-----
----------INNPVDR-------------SGEPHF--------------GTLPKALTKK
EHP--------PAINHLDSSSNPSSTTSSTPSSPAPFHS-SNPSSATTPPNPSPMTQRDS
RFNFPA-AYYIHHRQQFIFPELTHG----E-------------NGRV---------QL--
----------------STETL--KNPSAFA--LNLKVPWASNGESA-NDQPKAEA--A-E
EHEAETEEQE--------AAKSEPEDD-EDEVEDLPNSRPP---WKGTISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGKVYRGKWH-GEVAIRLLEVDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTALDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVQEGR---RENQLKL
PHDWLCYLAPEIVREMTPGKDEDKLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------F---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------W----------E---------------------------------------
------------------------------------------------------------
--------------GVKQVLATVSLGKEVSEILSACWALDLQ--------ERPSFTLLME
MLEKLPKLNRRLSHPGHFWKSADINSSKVVTRFERFGLGSLESSNPKI------------

MD------RAVL-RAAAMGE-KKE---GGGGGAAAAADGGSGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQRQCKLSVAPGDRTPELNSYPRF
RDWLDTFNVRPEVAQEILRELTGDQLDALLEMDEAKVKETLQRCGASAEECGRLQQALTC
LRKVTGLG------GEHREDSGWSSSEARRESGSGPSVDTLSL-----------LGRVGS
SAQGPRSVSVSALPASDSP------APGLSEGLSDTCIPLHASGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMRF-----
---------------------------DL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFP-------------------------------------------------------
------------------------DISAFP--QAAPPPDATDSTRP-DDQPKAEV--V-E
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------V----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESGNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLE--------------------------------
---------------EIPCDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS---------
-----------------------SMRFDL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLIIAENLKE--NTF---NISAFA--QAAPLPEAANGTRLD-DQPKADVLE---
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1681)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ASLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
----------------------------A

PF13543 // ENSGT00900000140880_0_Domain_0 (90, 182)

KLVRYICKQRQCKLSVAPSERTSELNSYPRF
SDWLYTFNVRPEVVQEIPCELT---LDALLEMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVPGLG------GEHKEDSGWSMSDARRESGSGPSMDTLSPASLPWPPGSSQLGRVGN
SAQGPRSVSVSALPASDFP------APGLSEGLSDTCVPLHASGRLTPR-ALHSFLTPPT
TPQLRRHAKLRPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSPMSL---PN
LA---------------------SFLADL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-ASFIHHRQQFIFP-------------------------VP---------SAGH
HW---KLCICF---------LFPADISAFA--QAAPLPDAADSTRP-DDQPKADV--L-E
VHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSCRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADID-SKVVPRFERFGLGVLESSNPKM------------

MD------RAAL-RAAAMG--EKKEGGG-GGDA-AGADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLLRYICKQWQCKLSVAPGERTSELDSYPRF
SDWLYTFNVRPEVVQEILRELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTRLG------GEHKEDSGWSSSDARRESGSGPPADTLSPASLSWPPGSSQLGRLGS
SAQGPRSVSVSALPASDSP------NPGPSEGLSDPFISLHTSGRLTPR-ALPSFITPPT
TPQLRRHSKLKPPRTPPPPSRKVFQLLPSLPTLTRSKSHESQLGNRIDEPA-----DL--
----------------------ASFPADH--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCRVCQKSMMFGVKCKHCRFKCHNKCTKEAPACRISFLPL--PKLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPASSNPSSATTPPNPSP-GQRDG
RFNFPA-PSA------------------------------------------------GH
C-WK--CL-WCRKLK---E-NF-VRLTC-P--QA--------------CRPFYS--L--L
LSF-QAEEPE--------ASKSEPEDD-EDEVDDLPTSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1680)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSAEPA-------ARCWGWGTICSVCPRLLPTEPLELVRAR

------------------------------------------------------------
----------------------------A

PF13543 // ENSGT00900000140880_0_Domain_0 (90, 182)

KLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEAKVKETLRRCGASSEECGRLQYALTC
LRKVTGLG------GEHKEDSGWSALDARRESGSGPPMDTLSPANLPWPPGSSQLGRVGN
SAQGLRSVSVSALPACDSP------APGLSEGLSDTCLPLHASGRLTPR-TLHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMSL---PN
LA---------------------SFLTDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-ASFIHHRQQFIFPGESFA----C-------------AICW---------PSQR
CC-----LI-AKRLKEEKLSIQQDSSLIGP--PSGSLYKPCFTLRL-DDHPKADE--V-E
VHEAAAEEPE--------ASKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDRLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------L----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLEPSNPKM------------

MD------RAAL-RAAAMGE-KKE---GGGGGA--AADGGAGAAVSRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVKYICKQQQSKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDEAKAKEMLRRWGASTEECSRLQQALTC
LRKVTGLG------GEHKMDSGWSSTDA-RDSSLGPPMDMLSS-----------LGRAGA
STQGPRSISVSALPASDSP------VPGLSEGLSDSCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMK------
--------------------------FEL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRITFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DISACS--QAAPLSSTADSTRL-DNQPKTDV--L-G
VHEAEAEEPE--------AGKSEAEDDEEDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM------------

------------------------------------------------------------
----------------------------A

PF13543 // ENSGT00900000140880_0_Domain_0 (90, 182)

KLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEARVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSGCSLLDARRESGSGPSTDTLSPASLPWPPGSSQLSRAGN
STQGPRSISVSAIPASDSP------TTSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------SMRFDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VS---------SAGC
CW---KCLLIAESLKE--KSY---NISAFA--QAAPLPEAADSTRFN-DQPKADV---LE
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNSKM------------

MD------RAAL-RAAAMGE-KKE---GGGGGA--AADGGAGAAVSRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVKYICKQQQSKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDEAKAKEMLRRWGASTEECSRLQQALTC
LRKVTGLG------GEHKMDSGWSSTDA-RDSSLGPPMDMLSS-----------LGRAGA
STQGPRSISVSALPASDSP------VPGLSEGLSDSCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVTPMK------
--------------------------FEL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRITFLP--LARLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAM-NLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
RFSFP-------------------------------------------------------
------------------------DISACS--QAAPLSSTADSTRL-DDQPKTDV--L-G
VHEAEAEEPE--------AGKSEAEDDEEDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMIPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDLQ--------ERPSFSLLMD
MLERLPKLNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------MNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS---------
-----------------------SMRFDL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NAF---NISAFA--HAAPLPEAADGTRLD-DQPKADVLE---
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSAEL------------------------------------

------------------------------------------------------------
----------------------------AKLVRYISKQRQYKLSVAPGERTVELNSYPRF
SDWLYTLNIRTDVVQXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXX
XXXXXXXX------GEPKDDPTWSPLDARRESGSGPPTDTLSPAGLTWTLGGSQLSK--G
SSQQARSVSVSALPTSDCP------TLCFGEGLSNSSISLHHSGRLTPR-TPHSFITPPT
TPQLRRQNKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVPSIX------
--------------------------XXI--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QICHVCQKSMMFGVKCKHCRLKCHNKCTKEVPVCRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLP--LPKLRRTESVPSD-----
----------INNPVER-------------PTGPHF--------------GTLPKALTKK
XXX--------XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXX-AYYIHHRQQFIFPXXXXX----X-------------XXXX---------XXXX
XX---X-------------XXXXXXISTPP--QAPQVPDTAEETRX-XXXXX--XXXX-X
XXXXXVEEQE--------ACKSELEDD-EDELDDLPSSRKP---WKGMISRK-ASK-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGKVYRGRWH-GEVAIRLLEIDGNNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKX
XXX-----XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX---RENELKL
PHDWLCYLAPEIVREMTPGKDEDKLPFS--------------------------------
------------------------------------------------------------
---------------------R----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------Q----------T----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVKHVLASINLGKEVSEILSACWAFDLQ--------ERPSFPLLME
MMEKLPKLNRRLSHPGHFWKSADINSSKVVSRFERFCMGIPESSNPKI------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSISVSGLPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-AEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RTAL-RASAMGE-KKE---GCGGGAAAAADGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSDRTAELNSYPRF
CDWLYTFSVRPEVVQEIPRELT---LDALLEIDETKAKEMLQRWGASPEECSRLQQALTC
LRKVTGLG------GEHKEDSGWSLSEARRESSSGPSVDTLSPASLAWPPGNSSLSRVVG
GTQGSRSISVSTLPASDSP-----AAPSLSEGLSDTCIPLHTSGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDDVSPMRC---SW
TE-----------------------SHYL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------ATEPHF--------------GTLPKALTKK
EHP--------PVM-NLDSSSNPSSTTSSTPSSPAPFQTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------PAGH
CW---NCLPESGLILCS-CSLFPLDISAFP--QASPLPNAADSTRL-DDQPKADV--L-E
VHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTALDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADITSSKVMPRFERFGLGVLESSNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCSVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPHDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSPASLPWPLGSSQLGRAGN
SAQGPRSVSVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEPA-----HP--
----------------------ASFPADL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NTFNSVNISAFA--QAAPLPEAADGTRDV-AEPRSAAHPCSF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
--------------QKISGELT---LDALLEMNESKVKETMRHCGSSADEVSRIQYALSC
LRKGTGL------GGEPKDDPAWSPLEARHESGSGSPSDTLSPAGLTWTPGASQLSKG-I
SSQQPRSVSVSALPTASDALPLGHGLSGYGEGLSDSYVSLHHSGRLTPR-TPHSFITPPT
TPQLRRQNKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVPSIKF-----
---------------------------DL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QICHVCQKSMMFGVKCKHCRLKCHNKCTKEAPVCRISFLP--LSKLRRTESVPSD-----
----------INNPVDR-------------STEPHF--------------GTLPKALTKK
EHP--------PAVNHLDSSSNPSSTTSSTPSSPAPFQS-SNPPSATPPPNPSPMAQRDS
RFNFPA-AHYIHHRQKFIFPGESLV----L-------------I----------------
------LLTAHRCSN-----FCLSYISAPP--QAPQVPNAAEETRV-NDQLKANV--S-E
DHEGEVEEQE--------ASKSELEDD-EDELDDLPYSRKP---WKGMISRK-ASK-TSV
YLQEWDIPFEQV

PF00069 // ENSGT00900000140880_0_Domain_3 (793, 1680)

ELGEPIGQGRWGKVHRGRWH-GEVAIRLLEIDGNNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNIFYDNGK-VVITDFGLFGISGVVQEDR---RENELKL
PHDWLCYLAPEIVREMTPGKDEDKLPFSRAADVY---AFG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------TVWYELQ----------------
------------------------------------------------------------
--ARDWPFQTQPA-----------------------------------------------
------------------------------------------------------------
----------EALIWQIG------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SGEGVKHVLAGISLGKEVSEILSACWAFDLQ--------ERPSFPLLME
MMEKLPKLNRRLSHPGHFWKSADINSSKVVSRFERFGMGIPESSNPKI------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPHF
SDWLYTFNVRPEVVQEIPRDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS-----SM--
----------------------RLPVALE--LHGKPS------HVPVSALCRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NPFN---ISAFA--HAAPLPEAADGTRAQ-ICC----PSLFF
LLSFQAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------KAAL-RAAAMGE-T-E---GGGGGDAAAADGGAEAAASRALQQCGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTSELNSYPRF
SDWLYTFNVRPEVVQEIPSELT---LDALLDMNEAKVKETLRRCGASTEECGRLQHALTC
LRKVTGRG------GEHKEDSGWSPLDARRESGSGPSTDTT------------QLGRMGS
SAQGPRSISVSALPASDSL------TPGPSEGLVDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSMSL-----
---------------------------DL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLP--LPRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMSHLDSSSTPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPV-ESPCL------------------------------------------------
--------------------------------PASPLAAFTVLPVL-NDQPKADV--L-E
DHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRT---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGNNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGMVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDKLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------I---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRILASVSLGKEVSEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
----------------------------AKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQVCKLGLR---AS--QELSPGPVKVALQRISGE--------ALTIC
DSTSWSTG------GEHKEDSSWSSLDVRRESGSGPSTDTLSPASLPWPPGSSQLGRAGN
SAQGPRSISVSALPALDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS-----SM--
----------------------RLPVALE--LHGKP---SVCKHVPVSALCRFSTKSWLS
QVCHVCQKTMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---TCLLIAEN------------ISAFA--QAAPLPEAADGTRLD-DQPKADVLE---
AHEVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MTPGKDEDQL

PF07714 // ENSGT00900000140880_0_Domain_3 (986, 1681)

PFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLASVSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSAE-------------------------------------

------------------------------------------------------------
----------------------------A

PF13543 // ENSGT00900000140880_0_Domain_0 (90, 182)

KLVRYICKQRQCKLSVTPSDRTAELNSYPRF
SDWLYIFNVRPEVVQEIPQELT---LDALLEMDESKAKEMLRRWGASAEECSRLQQALTC
LRKVTRLG------GEHKEDSGWNSADTQRESSLGPSVDMLSP-----------LGRVGA
STQGPRSVSVSALPASDSP------VPGLSEGLSDTCIPLHTGGWLNPR-SLHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPNFPTLTRSKSHESQLGNRIDEVSPMR------
--------------------------FDL--PHGSPQ--LVRRDIGLSVTHRFSTKSWLS
QVCNVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LARLRRTESVPSD-----
----------INNPVDR-------------ASEPHF--------------GTLPKALTKK
EHP--------PAM-TLDSSSNPSSTTSSTPSSPAPFLTSSNPSSATTPPNPSP-GQRDS
SFSFP-------------------------------------------------------
------------------------DISACP--QAAPLSSTADTTRL-EDQPKADV--L-G
VHEAEAEEPE--------AGKSEAEDD-DDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1635)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGRDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEV-------------------------------
---------------GHFWKSADINNSKVMPRFERFGLGALEPSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
--------------QEILRELT---LDALLDMNEAKVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------REHKEDSGWSSLDARRESGSGPSTDTLSPASLPWPPGSAQLGRMGS
NAQGPRSVSVSALPTSDFP------TPGPSEGLTDTCIPLHASGRLTPR-TLHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPISS-----
-------------------------RFDL--PHGSPQ--MVRRDIGLSVT

PF00130 // ENSGT00900000140880_0_Domain_2 (411, 458)

HRFSTKSWLS
QICHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRIS

ENSGT00900000140880_0_Linker_2_3 (458, 792)

FLPI--ARIRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PTMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------EP---------SQGQ
CPWLFQALLLGEWL-G--AFFP-PDISAFP--PAAPFPDAAD-STRLDDQPKAD--VLED
HEV-EAEEPE--------AGKSEAEDD-EDEVDDLPSSRRT---WRGPISR-KASQ-TSV
YLQEWDIPFEQ

PF00069 // ENSGT00900000140880_0_Domain_3 (792, 1682)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGMSGVVREGR---CENKLKL
SHDWLCYLAPEIVREMTPGKEEDQLPFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ASLGKEVTEILSACWAFDLQ--------ERPSFTLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALEASNPKM------------

------------------------------------------------------------
---------------------------QAKLVRYICKQQQCKLSVAPSERTSELNSYPRF
SDWLCTFNVRPEVVQEILSELT---LDALLDMNEVKVKETLRRYGASAEECGRLQYALAC
LRKVTGLG------GEHKEDSGWSSLDARRESGSGPSADTVLPAGLPWLPGGAPPGRMGG
SAQGPRSVSVSALPTSDSP------APGACEGLSDTSVLLHTSGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVS---------
-----------------------PMRFDL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPQTEPRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VV---------GSPH
C-HP--RA-CASLLK---K-YL-RNISAFP--QAVPSPDAAD-STRLDNQPKAD--VLED
HEA-EAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF00069 // ENSGT00900000140880_0_Domain_3 (793, 1678)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPFKNQAAEA
LIWQIGSGEGMKRVLAS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVTEILSACWAFDLQ--------ERPSFPLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

MD------RA-ALRAAAMG--EKKEGGG--GGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRDLT---LDALLEMNEAKVKETLRRCGASGDECGRLQYALTC
LRKVTGLG------GEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGN
SAQGPRSISVSALPASDSP------TPSFSEGLSDTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVS-----SM--
----------------------RLPVALE--LHGKPS------HVPVSALCRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPL--TRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP-------------------------VP---------SAGH
CW---KCLLIAESLKE--NAFS---KLDDQ--PKAD---------------------VLE
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVY---AFGTVWYELQARDWPLKNQAAEA
SIWQIGSGEGMKRVLTS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VSLGKEVSEILSACWAFDLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------MDEAKVKETLRRCGASAEECGRLQSALTC
LRKVTGLG------GEHRE--DWSSPDSRRESGSGPSADALPPASLPWVLGGAPLGRLGC
GAQGPRSISVSALPASDCP------TPGPSEGLVDTCVPLHASGRLTPR-ALHSFITPPT
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPGRS-----
---------------------------DL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--LSRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AYFIHHRQQFIFP----------------------------------------
------------------------DISAFP--QTALPSDAADSTRL-DDQPKAGV--L-E
DHEVEAEEPE--------AGKSEAEDD-EDEVDDLPTSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQ

PF07714 // ENSGT00900000140880_0_Domain_3 (792, 1681)

VELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKISLDINKTRQIAQEIVKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMAPGKDEDRLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------N----------Q
---------A----------A----------E----------A---------L-------
---I----------W----------Q----------V----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GVRRVLASVSLGKEVGEILSACWAFDPQ--------DRPSFTVLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKV------------

MD------RAAL-RAAAMGE-KKE---GGGGGDAAAAEGGAGAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPSERTPELNSYPRF
SDWLYTFNVRPEVVQEIPRELT---LDALLEMNEARVKETLRRCGASAEECGRLQYALTC
LRKVTGLG------GEHKEDSGWSLLDARRESGSGASTDTLSPASLPWPPGSSQLGRAGN
SAQGPRSTSVSALPASDSP------TTSFSEGLSDTCIPLHASGQLTPW-ALHSFITSPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGN---------------
---------------------------HL--PHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLP--LTRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPA-AHFIHHRQQFIFP-------------------------VP---------SAGC
CW---KCLLIAESLKE-------KPYNNGL--PQGLLDKPCFTLRL-NDQPKADV--L-E
AHEAEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPVSRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_4 (793, 973)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSRH---------QQDEG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREGR---RENQLKL
SHDWLCYLAPEIVLGPXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXLHLQEILSACWAFNLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNSKM------------

-----------------------------------------GAAASRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEARLVRYICKQQQCKLSVAPGDRTPELNSYPRF
SNWLDTFSVRPEVAQEILRELTGDQLDALLEMDEAKVKETLQRCGASAEECGRLQQALTC
LRKVTGLG------GEHKEDSGWSSSDARRESGSGPSVDTLSL-----------LGRVGG
GAQGPRSVSVSALPASDSL------APGLSEGLSDTCIPLHTSGRLTPR-ALHSFITPPA
TPQLRRHAKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSSVRF-----
---------------------------DL--SHGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLP--ITRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFP-------------------------------------------------------
------------------------DISAFP--QAAPLPDATDSTWP-DDQPKAEV--L-E
AHKVEAEEPE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISRK-ASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_3 (793, 1681)

ELGELIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGY-----LHAKGIVHKDLKSKNVFYDNGK-VVITDFGLFGISGVVREER---RENQLKL
SHDWLCYLAPEIVREMTPGKDEDQLPFS--------------------------------
------------------------------------------------------------
---------------------K----------A---------A----------D------
----V-----------------------------Y----------A----------F---
-------G----------T----------V---------W----------Y---------
-E----------L---------Q----------A----------R---------D-----
-----W----------P---------F----------K----------H----------Q
---------P----------A----------E----------A---------L-------
---I----------W----------Q----------I----------G----------S-
---------G----------E---------------------------------------
------------------------------------------------------------
--------------GMKRVLGSVSLGKEVSEILSACWAFSLQ--------ERPSFSLLMD
MLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGALESSNPKM------------

----------TL-SPVQFSFFIKKGGGG-DGERDRHTKKVPISLKCRALQQ

PF13543 // ENSGT00900000140880_0_Domain_0 (52, 182)

CGQLQKLID
ISIGSLRGLRTKCAVSNDLTQQEIRTLEAKLVRYICKQQQCKLSVAPGERTSELNSYPRF
SDWLCTFNVRPEVVQEILSELT---LDALLDMNEVKVKETLRRYGANAEECGRLQYALAC
LRKVTGLG------GEHKDDSGWSSLDARRESGSGPSADTLPP-----------LGRMGS
GAQGPRSVSVSALPTSDSP------TPGPCEGLADTCIPLHASGRLTPR-ALHSFITPPT
TPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDEVSPMSLLDL--
----------------------ASFPADL--PYGSPQ--MVRRDIGLSVTHRFSTKSWLS
QVCHVCQKSMMFGVKCKHCRLKCHNKCTKEAPACRISFLPQ--PRLRRTESVPSD-----
----------INNPVDR-------------AAEPHF--------------GTLPKALTKK
EHP--------PAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSP-GQRDS
RFNFPD-ISAF-------------------------------------------------
-----------------------------P--QAAPSPEAASP----PC-------VRFL
SHGDLAEETE--------AGKSEAEDD-EDEVDDLPSSRRP---WRGPISR-KASQ-TSV
YLQEWDIPFEQV

PF07714 // ENSGT00900000140880_0_Domain_4 (793, 866)

ELGEPIGQGRWGRVHRGRWH-GEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITR---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------