ENSGT00900000140842_2 : Linker Region Query Results

-------MATSPVLPTEDG-QG-FLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTAPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----KLAQTLSCD
YNQ-----PSPEVVSVV-A--SSPTSSPPTKKCSKAQAQARWQWS AKKALLQWAQEQCAG
-SES-VNVTDFKASWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPGPGGSTQA-KVRDAM--------VWL
TLQEKRFQKMLKDSASETYSNKYHS----LLSFMESLNEEKESFVDVLSLKGRMGELNED
ESRLQQGWASLMHQVAEWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTL
IQGKLSSFKSLMGSFDYHSDVLMAFQTNAEKSLPAVPPAKLEEMT-RRF-VTV-------
------------------------------------------PKFTGEKKFLVQLDASFQ
KCEEM---YKN------SARECESIREEYVMLEKNVHSCRQYIHNTKATLQRALMSWVTF
EEDLALLKASFDSTKKEQLKE-----VPVETLLQWNVKHTSLNEVGSFLIGVSSREVAAS
ISKELRRLNKRWRKFITKTPL-LKLPL-V-KIQDQPPGNSSGT----------S-L-SKE
--------SAMSAEPGGSRGE--DVK----------------------------------
--------ASEKREVEDEESAGQLKVNEEVEGLIKQ------VTTWESQTKSILDLLQHQ
DHAD--GSSADTLQHLIAKGSVYEELLARTEDTLQMDVQRPSNLEP---FQNVPRAGLQA
KIQE-AKQGVQITMVELSAVLKNLSDE-PLELDLGLKLEEAQKELESSISRAEQLLGQRE
RPGGLLLKYKEALEILNTNSLAKYLRAVEELKRTVPGGAKLQLEEQSRVASAKWEPLHHE
ISLYLQQLKIAIEEEKLRDNIARLEKQINKEKKLIRRGRTRGLRKEHE--ACLSPESIKC
QLEHHVGVLRVLCEE-LT--SPEDQQELKRALRDYEQKIARLLKCASEIHTTL-----QS
SQG-GA--LEERSALITTENGRRDADGEVPLEIPDNQLSTEK---A-MEPIKNFSQTSEL
KPQQEESIMEKEGKDCSASLSDLQERYDTQRELLEQHLQDSKSRVTSDFASEQERSSACL
QSKLAELQ-VLQADTDAHWEKFEITSLNLRRLMSDAEKP-VLNQERDLLKGNEQILHVLL
NDRMESLEMALQIVLPLEKECSLLCASD-LPLCTVAVQDLHPIDIDGVYQNLRD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIRVCTSL-EEPSNSVPRELH
TLDQYAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAELP-VDRP---
ALNAPEDTPAVRSAEEDILLMKEKAGPLDERLRTLGINVKDAEGGENTTCERLVGALSVN
LVAMDGQSKEEGPPEDKKLLEA-------CSSKNHELFKNIQDLQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKIVVQQCEDTAALWESTKAS
ITESLEQCGSALELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKIAEIETVKE
EFSNHLEVVDKINQICKTLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLG
RALALWDKLFIIKNNIDEWTEQILGKAESHELTEEDRGRLKEELKIHEEQTAEFSRRVAD
IQLLLQSNEKPLELQVMESSVLSKMKDVKTHVAGGSNSYAPSGNTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELSELKRQYASVS
NLFNTKKNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDFL
TLGGGNSKIQQVETVLQHVKMLLPKAHVKELDSWLRSQELELENMESICQARAEELNNSF
QQLLRLEDDCRSLSKWLTNQEENWEKTEASGERMDLFSQGLNRKREQFEAVAQLSDSLKE
HGL-TEG----EETIKESTHLIDRYQALWRQLHEIEEEDKLPAAEDQSFNDLADDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAE------HCEAPL
A--QETFTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKK-QQEAG
FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKH
LHESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSTTLDDISKEYFSLCDGSKDQIVVKER
M-QKLQELESRLRFQGGALKKASALAKSIKQNTSSVGQKI-IRDDIRSLKY-KQKDLENR
IESAKQETENGLNSIL-KSKSSTEK----HVKF-SLPVEEMPATSEAPKPTQESAAVGES
GGARETNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLNVQESMQNAQDEREVNELQNQPL
ELDIMLRNEQLKGMEELSTHLEARRAATELLKQPQHLNQTGEQASVLPTARPSVCPLGSL
QQELRTLKKTKERQYGLLNGFQDQLAVAEASLNTSLAEVESLKI-GSLDSATYLGKIKKF
LGSVEKQQGSLSKLCTEWAHLSGLLAAADQKLVESQMKHLEHGWELVEQLAHRKCFQQAT
EHSELTCLLEKLQDLMVSL-H---QQQQRLTLSLNSPGQQVAIVDMVTPATELQAIKCEF
FGLKWQAELHMKRLWGEKDKKTLEDAINNLNKQLEAL-EPLNREVE-----NRIKKCELQ
NRIKETLSWVKNTMAELVVPIALLPDNILSQIRKCKLIHDGILGKQQAVELLVEEVRGIT
PSLVACEGDGLNALLEDLQSQHQALLLKSTQRSQQLELKLEEKSKLFAIIGKAQLTLEES
ETLMSPTGDRAS-TEAELERRLDILKASQQQLQDTESALSAHLQELTNAYKDANVFERLF
LDDQLKNLKARTNRTQRFLQNNCSELKHKIESYREFHDKAAVLQKEVES--ILHSGLLPL
HQ----ELEQDAKEQLGNLRDKLAAIRGRLSQVLTSEEVFDTIGLSWDGSLLA---QLQT
QVLEREREVEEKSKQLDTFLIARDKHQASISKIRAVDLQIKKGAESLLKVPSMSPAESTL
LNAQTLIRKIEKSKRLRDEIIRKLSKNEAFDDSFKESEIQQLKLSAEENSRLQEAL-QNM
LLELQPREMGEKEFQEKLENVLHVLKQIKSRLQQPLCVNLGVRHIQQEKETWEAFGEQVE
AEMCGLRAVRIAGEQRE-ENDS-GTGGMEAKLRDIEGLHMELSKSIGLRADVLNDAYDSA
NRYDKLVAGASRTVTSLEAMLLSYRVDLHNPQKSLELAHLK-QEELQSAVADLRSLTETL
GAISSPEAKEQLHCTLEALAAKNSALKAGLEAQEAEED--RCL------ENYKCYRKMKE
EICSRLRKMEMDLRQSIFLLPRSYKEALARLEQSKALTSNLLSTKEDLVKLRQLLRHLRS
KSTENDATCMLGVASALWEKWLSLLEAAREWQQWGGELKREWKFITEEIEREAIILETLQ
EDLPEISKAKDAAPTEELWQLLDSLCQHQESVEKQQLLLALLLQRVRSIQNIPEGTETGE
T-IPALQEIGSMQERCDRLLQTTQKNKDLVQAEIQAQQSFLKEIKDVKRVFEQISTSFPN
LAPEGHPERAEQFEELRSILQKGKLSFESIMEKLRIKYSEMYSIVPAEIGSQVEECRSAL
EDAEEKMSSEVSKSSPSSVMRRKIERINNGLRCIEKMLQQKSRNIEEAHEIQKKIWDELD
LWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYSDLLKNTEAWIEKTNRLLANPAYYDSSRTLSHRASTLQMA-LEDSEQKHSLLHSIFTD
LEDLSIIFETDDLIQ-TIHELSDQVAALQQQIIEALPHVQQVADDVVAIESEVKSMEKKV
AKIKAILL-SKEIFDFPPEEHLKHGEVILENIHPMKKTIAEIMTYQVXXXXPRLGFLAAV
KVILENIHPMKKTIAEIMTYQVELRLPQTGTQPLPVFQRTSQLLQDVKLLENVTQEQNEL
LKV-VIKQTAECDEEIDSLKQMLTNYSDEISPEHVSQNQVADLPSLQG-EIERLEKQILN
LNQKKEDLLVDLKTAVLNLHEHLKQEQQEVGDKPSA----GA-SECTVAER-DASERKL-
--SRTNSMSFLPVVKEEAEESSVKSEDGHRRTEPPSAS--WSLLGKHGKDL-EGDGASSS
SSATIVQD----ADGRISTCDSSMVCIIAPDWGSTE---EGPEPAPRLSQTDEGATPPIE
TALLDFPREQG-TFESTV--ERSRPQPADVLRVCKTQVAKLELWLQQANVAFEPETVDSD
MQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGTTQQEAEALSWKLKTVKCNLE
KVQMMLQEKYSEDQ--HPSTLMKP--S--EPHTVDQPSSLSELDSVLTERPQFSRQKDAP
QPQ--ILELKLSEQKDLIKFTELN-AKKTWLQGHQENEDE-NRQSAS----------SSK
VPSPGNAASDSTLPPQAQ-SGDKWQY-----L-HHELTSRPNPPVP-QLVESQVALTTST
LPSVSVYNFRCPTADELQAYTTQLEELRQEANTLQTQGSMTEETYISLDKRLFELFLSLS
RCLGSVEELLQRPGLLQEDACAQQVFF----QKLALELKKLYLALGDKKDDFLKAVTWPG
KEATLLPECIDALTVSLESAQSRAAWKGASLKAGLDHSRSYQNEVKRLYSQLIKKKTALQ
QSLNEISGQSIGKQLQKADVHTAELQNSERQVAKLRDEGERLRFPHGLLQDVYKLEDVLD
SMWGILRARYLELSSPFLSKSLQ-TLLQGMAELVSIGKGKLAADPLQHAKSKAALQAQLQ
DHKAFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSML
QKWEEFDDNYASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQ
TLNEGKQLAASVSCPEPEGQIARLEEQWLSLNKRIDQELHRLQTLLKHLL------SYSR
DSDELTRWLESSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMINW
MNAVEPQAAGKDAELSKSSASQVKHLLQKLKEFRMEMDYKQWVVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEE
RLKMLQKPESAVSMEKLLLDCQDIENQLALKSKALEELRQSSLTIDG-GDVPLLEDMASG
IVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAV--L
SLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASS-PSIAGIIEEKCQDAH--SR
WTQVNQ---DLADQLQEARGQLQLWKAPHNAHAEAAAWLQQQEAKFQQLANTNLSGDNLA
DILPRALKDIK-GLRSELRKTKEAFLENSTLSDQLPQ-PEERSTPGLHSGQRHSLQTAAY
LERMLLAKSNEFEIVLAQFKDFADRLAYSKDLI-VHEEENLNKLYHEEK--EDVPDLFLN
HVLALTAQSPDIERLNEESLRLPLSDVTIKTLQSLNRQWIRATATAL-DHYSELQGNGLN
-EK-FLHYCERWIQVLEKIQESLSVEVAHSLPALLEQQKTYEILEAEVSINQAVADAYVA
QSLQLLDTAEIEKRPEFVSEFSKLSDQWQRAARGVRQRKCDIGRLVTQWGFFT-TSVE-D
LLRFLADTSQLLSAVKEQDCFSLCQSRRLVHELKSKEIHLQRWRTTYELALEAGEKLRD-
-TPNPETREFVEGQTSRLQESWKDTELSLGEVISRLQSTA-ETWDQCKKKIKKLKKRLQA
LKAQSEDPLPELHEALHEEKEQIKEVEKSLANWTHSLKELRTMKADLSQHILAEDVTVLK
EQIQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSI
EEMIEKLQ-----------------------------------------------KDCME
EISLFTENK-LQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDNQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIED--PREIQADSWRKRRESEE----
PTSPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISEGHP------
------------WHVPDSPSHSKHHYKHMEGDRTAAPVPTDASTPFKPDYVKLLLRQGT-
DDSKEG---LKEAQ----Q-ED-EQLATLTG-QQ--PGAFDRWELIQAQELHSKLRLKQT
V---QQLKSDIGSITAWLGKTEV-ELEALKLAEPPSDIQEIALRVKRLQEILKAFDTYKA
LMVSVNVSHKEYLPSQSPEATE--LQNRLHQLSLSWDSVQGVLDSWRGDLRQSLMQCQDF
HQLSQDLLLWLATAESRRQKAH-V-TSLEADRQVFLECQKELMHLEKELVARQPQVSSLR
EISSSLLVKGHGEDYIEAEEKVHVIEKKLKQLQEQVAQDLMSLQGSLDPDA-SLTS----
--FD--EVD-SGE-QLPAAFAKSPRPRWTFL-----EEEEEEEETD-------SRMPHLD
SPG-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWEGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPKKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVKVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDSSGN----------I-V-SKE
EKATVEFSTDTSIELPEYSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKNRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-IEATMKFNLASEL
KPPQTGSIM---EKDYSASVNSLLERYDTYRDILENHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKKETDVCWKEFEIISLKLENHVSDIKKP-FIIKERDKLKERERELQMTL
NTRMESLETALQLVLPVEKASFLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLGALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELRKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKIHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENAKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTEISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVNQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMIMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQPLDSL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVV
EYDEFTALMNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQRSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKLQLTVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKNLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRE-EEKSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEATIIPYRVDVGNPDESLEMPLRK-QEELESTIAHIQDLTGKL
GMISSPEAKLQLQCTLQELVSKNSAMKETFKARKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQHIRSIQNVPESSGAVE
S-VPAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINHGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQRHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EEGGVAER-DASEWKL-
--SRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISICDNSMAQILTPDSLNTE---QGPERSLKPNQTEEGTTPPIE
A--LDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDRGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSALESIVTERPLFSRQKDFQ
QQ--QVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDT-AQESSA----------SSQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEACIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLRSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTESQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSGVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFE----------------------------------------------N
HVLALTAQSPDIEHLNEVSLRLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKGDIDGLVRQWQDFT-TSVE-I
LFRFLNDTSHLLSAVKGQECFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLMKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKTFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRAKFRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASGPVLPNEDG-QV-SLGIDDLHI-----SLH---------AEQEDTQKKAF
TCWINSKLAKHTPPSVVSDLFTDIKQGHILLDLLEVLSGQQLPRDKGTNTFQCRINIEHA
LTFIQKRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCS
YNS-----PSLDSVSAV-D--SSPTSSPPAKKCSK--TRARWQM SAKKALLSWAQEQCAT
-DES-VNVTDFKTSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLNEAFRIAERELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLQYSKDKLGTGDKAQG-KMKEAM--------AWV
AQQETKLQNVLKDSENKTYSEKYES----LLSYLESFNEEKKPFLDILPLKDNLDEPNED
QLQLSVTWNGLNSKIHLWKTKLNDALPSPLHQIEAWLQETEKLIDEDLPASQDYFAAMTL
LQEKMTLFKALMDKSDYYLNILLAFENRDEKHLPLVPANKLEEMK-RRI-NNISGKKFIT
LLEFHYYKYAVLGLLKEVKSKLDIWNIKYGTKESVELLLVDWQKFIEEKEFLAQLESSFK
KCEES---YKN------LXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-----VPYETLSQWNLAHVTLNEAGDFLIQVSSDEVGTS
ISKELRRLNKRWRKFIPKAHLEMKQPL-L-KTQDQPVLDNSGS----------I-HLSEE
EKRTVDFSADMPVECPENHNQ--NIK----------------------------------
--------SGEKQEKECEEFTGQLKVAEDFEKLIGQ------VQVWEAEAKSVLD----Q
DDIS--PSVGESLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXSHES---LQHILTAGLQT
KIQE-VKEKVQINMTKLVIALKNSIEV-SPDLDVKWKVENSQKELESSISKAEQLLSQRE
SKSELISKYKEAITIFNTRSLTKYLKAVEELKSNATEVVKLSLEEKSKEICTRWEXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--ACFSEEGYLY
HLDHHMQVLRELCEE-LT--SQKTQQEVRRALKDYEQKIERLRKSASEIQMLL-----QP
MVG-GT--SKHKGTTSTSENGGRDIHSEVSSAKSDYQMPNEK---P-MESK-MYGQESEL
QPQQEERS----EVDHNASKNNLLDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-ILKNETEACWKEFEITSLKSEELVSDTHKS-LVVKTRDQLKRKERMLQKTL
NTXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSLTKQIEICNSL-EQSDNFVLKELD
PLDLHATQDIIVKHRLQLEEMNHKMQMKEEGLKALEDFLSSLRIAENSP-------VASY
TQVAQENTLTVENKEGEIHLMKEKARDLDEQLKILGISLKDARLAEDASCEKLLDTFSKK
LFETHSHGSQEELSEE-KLLET-------CIFKNNELLKNIQDVNSQLSKISLKDPTVPA
IKQRKKSLIRLDKDLDDYEEERRHLQEMTNSLPQLKDARKKALNQQFQNTAILWENTKAS
VTECLDQCERVLELLRQYQVLKNILTTLIQKEENVISLQASYMGKEYLKKRIAEIEIVKE
EFNEHLDVVDKINQICKNLQFHLNKMRTFEDPPFEKEANIIVDRWLDXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGDLEIHQKSL-EFSEKVAK
IQLLLQGS-VRLELQVMKTSILKKIEAVKACLLGESI------STAELQEDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELYELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSDIKMNLKDCFESSETKNNMEEKLQKLSXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXLQDDHKNLSKWLTNQEEKWKEMEESGEKTDLFYQVLDRKREQFESIAQVNNSLKE
YGI-T-E----EEIIMESTHLISRYQTLLGQLSEIEDEDKLTAAESQSFDDLAHDVIQWI
TEIKESLMVLNSSEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXX------XXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------XXXX--NSSVEMVLSKQLSPDVHESMKTTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELYMQLEAQKAAIERPGQTEFLSKTETNALVLNNARFSVHHLDSL
LQTLMTIKKNKESQYRLLEDFQEHLAAVESSAKALLTEKESLKV-GPLDSITYLEKIKKI
LTLIEKEKCSLRKIKSEWENISNCLADMDKKFLESQIKKLEYSGEQLEQLVQKKYSQRVV
EYNEFTFLMNKIQDLEVSL-Q---QLQPYLHLRLNSPEEQAENQSLVAIVTELQTIHQRF
SVLKRQTELQMKRIWGEKEKMVLEDAINNLQKQLEVL-QPINREIE-----NQIEKCEVR
TKMKETIVWVKTLLGELIPPTSHPPDDILSQIRKCKMMHDDILKKQQAVESLFEEVKDNI
PRLTARENDDVNN----LQHEYQMLVLKSTQRSQQLESKIEERRKYAAEIGKVQLLLQGN
EALIIPPVETAS-TEAELEHQHVMLMASQQELQETESAISTYVQELTKLYKDLTVVERGF
LVDHFK--RPTKSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX-X
XX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXSILNDASENM
LHYEEAVNRAKGLITMLEAIFVSHKVDLEKPEESLERPRWK-HKELESTIADIQNLTEKL
RAVSSPEAKLQLQCTIQDLVSKNSAMRDALEVKEAEVE--RCL------ENYTCYRKIKE
KLYTDLSQMETDLGQSISPLPVSYKEALERVEQSKALVSNLMSTKEGLVKLRQVLRYLRP
ICTEHDGTCLLRIVSSLWDKWLSLLEAAREWEMWCEELKQEWKYVSEQXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIEGQVEECRKAL
EDVDEKISSEVLKSSPSYAMSRKIDEISNGLHNVEKMLQQKSKNIEKAQQVQKKMWDDLD
LWHSRLNELDSEVHDIVEQDPEQAQEWMDKLMVPFQRYQQVSQRAESRTSQLNKATVKME
EYHDLLKSTKTWIENTGHLLDNPVDYDSSKMLSQHAHTLQMA-LEDSEQKHNLLLSIFTD
LEDLSIIFETDNLAQ-LIQELSHQVAALQQKIMESLPQIQQIADXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXX----------------------------------
-VILGNICPMKKAIAEIMSYHVELRFPQTGMKSLPVFQRTNQLLHDIKVLENVTQKQNE-
GKI-AIKQTNECDEEVENLQQVLNNYSTELSHEDRSPDQVSNIPHIQG-EMEDMEKQILS
LNQKKEDLLVDLKATLLNLHQHLQQEP-ELE--KEAPSGGVS-EEDGVAER-DVSTRQL-
--NRTGSMSFLPAVEEEAEESSLKSEXXXXXXXXXXXX--XXXXXXXXXXX-XXXXX-XX
XXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXGATPPTK
AAVLGFSDEQG-ALEATV--ETPRLEPAEVLHVCKTQVAELEVWLQQANVAFEPETLNAD
MQQEVEQQLVGCQTMLTEIEHKVASLLENCKEQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--NSAFLKKS--S--EHQKVFQLDNLPGFESVITERPQFSRQKDF-
QPQ--XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX-XXXXXX---------XX-X
XXXXXXXXXXXXXXXXXX-XXXXXXX-----X-XXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXENMTEETYLNLDKKLFELFLTLT
QCLGSVEEMLQTPELFREDVCAQQVHY----ETLALELKKLFFALSDRKDDLLKAMFWPG
KTTTLFPGCVDNLQVYLEHTQATAASRSKSLKAGLDYKRSYQNEIKRLYDQLIKNKASLQ
QSLNEISSQNIDEQLQKADAHTMELQNSESRVAKLRDEGERLHLPYVLLQDVYKLEDVLD
SMWEILRAWYTELSSPFITQSQKDALLQGLAELVVTGKEKLAHDLLQQTKSKSALQTEIQ
NHKLFFQKLVADMLLIQTYSNKMLPSLLQKKETLWAEQVKEVKLLEERSLHCGIKLQSLL
QKWEAFDENYASLEKDLEILVATLPSVSLVEETEERLVERISFYQQIKRNVDEKRARLYQ
TLNEGKQLVISVSCPELEGQIAKLEEQWLSLNKRIDHELHRLQTLLKYLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLETIRSNINKFFEFTKELDDKSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWAMFITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTVHEDSEHSLSSASQVKNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRIHGSLNTKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTMQKPESVISVQKMLLDCQDIENQLAIKSKALDELNQSYLTSES-GRVPLLEDTASR
IDVLLKKRNSVIHQVSDLKASTQSVLQEWKMYDKLYDEVTVMTIRFQYCMEHSKPVL--L
SLEALRCQVQKLQSLQDEAENSEGKWEKLQEVIRKLKDYC-PSVAEIIKEKCQDTH--TR
WTQINQ---DIADHLLKAQSLLQLWKTHNGAHTETVAKLEQQEAKYQQLENINMSGNNLE
EILIPALQDIK-ELQLEVHKTKEAFLQHSTLLDRLPK-PMEPSTPVSLCDQQQPIQRASY
LEKMLLMKSNEFEFVLSEFQGLGNQLESLKSLIMLEEENLNKLYEQQEK--EEIPDLLLN
HVLALAALSPDIEHLSEESLKVPLSDIAVKTL-NMKRQWIRATATAL-ERFXXXXXXXXX
-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMLDAQVSINQTIADSYVT
QSLQLLDTTAIDKRPQFVSDFTKLTDQWQSAAQGVRQRKSNIDELVRHWQYFT-SSEK-E
LLHFLNNTSHLLSAVKSQDCYSHCQARSLIHKLKNKEVRFQRWQPTYALTIEAGEKLQNT
STTDMETKELLNTRIHHLQDNWKDTKLQVGEMIKQLQSTV-ETWDQCEKKIKELKNRLQV
LKAQSKEPLPELHEDLHKEKELIKELEKALANWIQNLKELHTMKADLNQHILVEDVMILK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNTTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLAQIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARETCTDMGS
DLRQIVAEG-QRWDTLQRSVRAIXXXXXHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLT SHAPGLEDEKEASENEADMED--PREIQTDTWRKRRES-E----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEAPFYSALSDVEIPENPEAYLKMTTNTLKASSXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKLLLSPGTDGGKEDPSVLKGDSQQGN-
EDLASL---AGQQ-----------------------PGAFERWELIQAQEFHDKLRLK QN
L---QQLNSDISDITTWLKKTEA-ELETFKVEKPPSDVQEMQLRVKRMQEILKAFEAYKA
LMVSVSVNSREFLQAESAESKE--LQSRVGQLSLHWDSARCAVESWRESLR RSL MQCQDF
HQLSQNLLLWLANAESRRQKAH-V-TEPNADPQVLLECRDELMQLEKELVECQPQVNSLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLMSLQESQNPDL-PLPG----
--FD--KVD-SGD-QLSAASLRAPQV-KFGA----EKTTKGKNQTG-------SRAPSPS
GSS-SSRPPRSFLSRVIRAALPLQLLLLLLLFLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSTVFPAEDE-QA-SLGIDDLQI-----SLQ---------AEQEHTQKKTF
TCWINSQLAKHSPPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNQS------IKLINIHVADIIDGNPSIILGLIWTIILHFHXX----XXXXXXXXX
XXX-----XXXXXXXXX-X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX
-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXVDVPNPDEKSVMTYVAQFLKYSKDASGTREETPX-XXXXXX--------XXX
XXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXDLIDKCDCHLKTLSAFKNKDEKHLPLVPPSKLEEMK-RRI-NDILGKKCIP
SLEIHHSVCPVLGLLDELKSKFDVWNVKYGSKESVELLLEDWHKFIEEKEFLAQLEASFQ
KCGEI---NQD------LARDCQNINKQY-MMDGKICVYRKRIHTVKSALQNILACWASY
MEHLRLLKA-FEEMKKDKLRV-----VPFETLSQWNLGHTTLNEVGNFLIEVSNDEVGSS
ISKELRRLNKRWRKFFTKTQLEMNLPL-T-KKQSQPIVDNFGN----------T-QLTKE
EKSATDFPTDMSVKPPENHNA--DLK----------------------------------
--------AGEEHEEN-EEFTEQLKQVKEVEKLIEQ------VGIWKAETKSVLELLRPQ
DDMA--ASVEESLQPLIAKGLMYEELVARTEDILQMDVQSLSGQES---LQHVLTAGLQA
KIQE-AKEEIQINMIKLLAVLKNSTDV-SPESDVRLKVEESQKELESYITRAEQLLGQRE
SRSGLSSKYKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--ACFSEEGNLY
QLDHRLEVLRELCEE-LT--SQKSQQEMKRVLKDYEERIERLRKSASEIHMTL-----QP
VVG-SV--SKKKGTMNPSENGGRDIHSEVPFAESDNQPSAEK---A-VEPMKNFSLESEL
ELQHEAGTVKKCEKDYNASVNSLLERYDACGEMLELHLRNNRFRITSDFSSDKEMSSDCL
QEKLTDLQ-VLKDETDARWKEFKITSLKLESLVSDVKKP-VIAKARDTLKGKERELQMAL
STRMESLETALQIVLPVEKEALFLCNSD-ILIYEIAIQELHLTDADSICQNLKN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DAIAKQIEICNNL-EKSGSFASKELH
PFDLHATQSIVQKCKAQLEEMNYKVQRHEDTLKNLEDFLASLRRAEPSVELI-TDVSTSD
TQVVPENTLSIENEEGKIHLMKDKARCLDKQLKMLGISFK----GADGSCEKLTDILSAK
F------GVYEELTEENKLLEI-------CLFKNNELLKNIQDVQNQISKIGLRDPTIPA
VKQRKKSLIRVDKDLDEYEEEKKYLEDMANSLPQFSDGREKALKLQCQNTVLLWENTKAS
VTECLEQCERVLELLKQYQNFKSILANLIQKEENVISLQASYMGKENLKKRITEIEIVKE
EFSEHLEDVDKINQICKNLQFQLNKMRAFEEPPFEKEANVIVDRWLDVNEKTEEYYENLG
RAVSLWDKLFTLKNVIDEWLEKVLHRVELHPLTEEERDKLKEELQVQEQKLPEFFTRVAE
IQFLLQTSEIPLELQVMESSVLNKMERVKMGLTGESSRGTLSGNTDELREDLDQAKTRIG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSNLLNDQCKNFSDWFTNIKMDLKECFDSSETRKSVEQKLQKLTDFL
TLEGRDSKIQQIGTVLNQVKKHLPKANAKELSSWITSQEFELENMKSICQARAKEFDDCL
QQLLRLQDDHRDLSNWLTNQENKWKAMEDSGEKTELFWHALDRKREQFESLAQLNNSLKE
CGL-TEE----EEILAQSTYLIDRYQTLLRQVCETEEEDKLPLTENQSFNDLAHEVIHWI
TEIKESLIVLNSSEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXX------XXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLECTKNPSFSEDPWLEIK-
LHESLYQLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
X-XXXXELESKLILQDGVLEKILTLAESIKQSSSPVGQKI-IKDDITSXXX-XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------XXXX--NSAVEMVLSKQLSLRVQESMKNAEDEQKVNELQNQPL
ELDIMLRNEQLKDIEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-ATTGIATYLDKIKKF
LASIEKEKDSLSQLKIKWENISTHLTDMDKKLLESQMKQLEHGLAQMEQLVQKKYSQQVV
ESDEFNFLMSKIRDLDTSV-Q---QQQQGLQLRLASL-QQEGNPSMVSLASEFETIKHGF
TVLKGKADLQMKRIWGEKEKKTLEDVINNLQKQLESL-EPLNLDVV-----SELKKCEIS
NQMKEMILWVKNLSDKLGHTVSLLPDDILSQIRRCKRMHDGILEKQQMLESLAEEVKGNT
SHMSAQEPSDLSNLLQDLQNQYQMLALESAQRLQQLEFKLDERSRFSAAMEKVHLSLQRN
ETLIIPKMETTP-TKAELECQLVTLKTSGEELQEIESVISTYLQELANLDKDLSVFERLF
LADQLQNLKTRASRTHRLIQSKRDEVEHKINFFREFHEKTSRLQKEVDS--IQHSELL-L
NQ----EVNQDVKDEFSNFKGRLTVTQSGILQLLKLKDVFDCVGLDWDISQLD---QLQT
QVFEKQKELEEKMKQLESFVA-HSKYQASLSKMRAVD---SKKKAAVLKSFSTSP--SSL
LSAHVLNQQIE-AMCLYHEMIKKLSENNAFDXXXXX-XXXXXXXXXXXXXXXXXXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XYL------ENYKGYRKIKE
KIGTDFSQVENVLAQAMSQLPLSYKEALEHLEQSKXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXELQSILKKEKLTFEDIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIEEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKMWDELD
LWHSKLNELDSEVQDIVEQDPAQVQEWMDNLMMPLQQYQQVSQRAETRTAQLNKATVKME
EYHDLLKSTQAWIEKTSHLLADPTDYDPSRTPSQHAVALQMA-LEDSEQKHSLLYSVFSD
LEDLAMIFETDDLAQ-SVKQLSSQVTTLQQKIVETLPQIQRMADDVVAIESEVKSMEKKV
LKIKTILL-SKEIFDFSPEENLKHGE----------------------------------
-VILENIRPMKKTIAEIMSYQVGLKLPQTGMKSLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQINECDEEIENLKAVLNNYSTEFSLEHMSQDQAAXXXXXXG-EISNMEEQILS
LNQKKEDLLVDLKAAVLNLHQHLQQEQ-ELE--RELPSAAAP-GGGGVAEA-DVSEWKL-
--SRTGSMSLLPAVVEEAEEISVKSENGDKKGDPSSSS--WSSLWENDRDQ-EEDRA-SS
SSGTIIQE----ADGRISTCDGSMAQVLAPDSLNTQ---QDPEFSRSPSHTEEGATPPIK
AAAQGFPDDQQTAFEATV--EKTRPEPAEILHVCKAQVAELEQWLDQANVALEPETLNAA
MQQVVEQQLVGCQAMLTEIEHKVASLLECCKDQGLGDGGDKQQEAEALSLKLKTVKCNLE
KFQMMLQEKYSEDQ--XXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX--VLELKPMEQKDLIKIXXXX-XXXXXXXXXXXXXXX-XXXXXX---------XX-X
XXXXXXXXXXXXXXXXXX-XXXXXXX-----X-XXXXXXXXXX-XX-XXXXXXVAPHVSV
LPSVGVYNSRYPTAEELQTYTIQLEDLHQEANNLEIQENTTEETYIHLDKKLFELLLALS
QCLSSVEEMVQNPALCRGDVYAQQGHC----AALALELQKLYSAMSDKKDGLSKAVACAG
KNTNLFLECFENLQVCLEHTQATVASQSEALKAGLDYHRNYQSEIKQLYDQLIKNKTSLQ
QSLNEISSQPVDEQLQKADVYTTELLNSESQVAKLRDKGERLCLPYGVLQEXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXIFFQKLVADMLLIQTYSNKIFPSLLPKKEAFWAEQVKEVKSLEEKSQQRGLQLQSLL
EKWEDFDENYASLEKDLEILISTLPSVSLVEETEERLMERISFYQQIKRNVDEKHARLYQ
TLNEGKQLVASVSCPEVESQISKLEEQWLSLNKKIDHELHRLQTLLKHLI------SYNK
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFDFSKEVDEKSSLKTAVVST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MDSVEHQTAEEDTVQSPSSASQVKNLLHKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTE-AEHLGEMNRQWHRLHGTLNRKIQHFEQLLESITENENKIQILNNWMEVQEE
RLKTLQKPGSVISVEKTLLDCQDIENQLAIKSKALDELRQSYLTLEHVCTLPLLEDTASA
VDGLFQKRNSIISQVSQLKTSIQSVVQEWKIYDQLYDEVTVMTVRFWYCMEHSQPVI--L
SLEALGRQVQNLQALQDEAENSEGSWEKLQEVVGKLKNYC-PSVAEVIEEKCQYTH--TR
WTQVNQ---AIADELQKAQSLLQLWKVYSTAHAEATARLEQQEAKYRQLASISMSGNNLP
EMLTPALQDLK-ELQLDVQTKEAVL--HNAPLERRPL-SAESSRAVLLSSQSHSLQRVAY
LEKMLPVKANELELVLSQLKDFEARLESLKGLI-MHEEENLDKLYQQEE--ENPDSIL-N
HVLALTAQSPDIELLNEVSLKLPLSDIAVKTLQNVNRQWIRATATAL-ERCSELQGRGLS
-EQ-FLYYCEKWLQLLEKMEEMLKVNIASNLPALLEQQKSYEMLEAEVSINQTVAESFVT
QSLELLDTAEVEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNKEIYFQRRQTTYALTLEAGKKLLS-
-TTDLETKESVDKKIRQLQDTWKGTVLQVGETIKHLQSIV-ETWDQCEKKIKELKSRLQA
LKAKSTDPLPELHEDLQKEKELIKELEKSLAHWTQDVNELPTMKADLTRHVVAEDVMVLK
EQIEHLHRQWEDLCLRVALRKQEIEDRLHSWIVFSEKNKDLCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINTFSENK-FQLKQMGDQLIKASNKTRAAEINDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-XXXXXXXXXXXXXXXXFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLEFLNKQYRWLSRENRTDAAS
KLKQMVHEGNQRWDNLQRRVTAVLRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTARAPGLEDEKEASENETDMED--SREIPTDSWRKTGASEE----
ASSPQSLC----HLVPLAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQMEGDQSVPPIPSDSSTPYKPDYAKLLLPPGT-
DGSKES---PRVLHSGPPQ-ED-KGLAG----LSVQQSXXXXXXXXXXXXXXXXXXXXXX
XX--XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXEISKTFDTYKA
LMASVHEGGKEFLQTESTEPKE--LQNRLHQLSLHWEAVQGAVDSWREGLRQSLMRCQDF
HQLSQSLLLWLASAENRRQKAH-A-ADPKADPQVLLECQHALMQLEKELLERQPQVNSLQ
EISASLLIKGHGEDYIEAEEKVHVIGKKFKQLLKQVSQDLKALQGSQNPDP-SLSG----
--FD--GVD-SSG-QHPAASVPATHT-KVGA----EKTTKGKNQTD-------SRVPGPS
G----SRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLPTEDE-QV-SLGIDNLHI-----SLQ---------AKQEDTQKKTF
TCWVNSQLAKHSSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGTNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVDGNPSIILGLIWTIILHF HIE----ELAQTLSCH
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--ARARWQM SAKNALLLWAQEQCAT
-HES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMRTVKHGSNKDNLKEAFRIAEQELKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLQYSKDAVGTGDKAKG-KVKDAM--------VWL
TLQKDKLQKVLKDSENETYFKKYHS----LLSFMESFDEEKKPFLDILSVKRNPDKLDED
QLQLREAWDSLENQINAWKTQLNYL---PLKEIEAWLQEVEQLRAEDLPSSQDYSEAMTL
TQEKMTLFKNLMDRFDCYSNILLTFENRDEKHLPLVPPNKLEEMK-RRI-NNISGGKSIL
LLEFHYYKCSVLCLLDEVKSKLDVWNIKYGNKDSVELLLEDWHEFIEEKEFLVQLDTSFQ
KCEEI---AKN------LAGECQNISKQYVMVKDNVCMYRKNIYNVKSTLQKVLECWATY
MENLRLLKDCFEETKKEQIKE-----VPFETLSQWNLNHTTLNGAGNFLIEVSDDAVGSS
ISKELRRLNKRWRKLVSKTQLEMKLPL-I-KKQDRPIFDNSGN----------I-L-SKE
EKPAVDFLVDTSIELPEYHYQ--NIK----------------------------------
--------AREEHEKEHEEFIGQLKVAEEVEKLIGQ------VEIWEAETKSLLDLLRPE
DDVD--TSMEESLQRLIAKGSMYDELMARAEDTLQMDIQSISSQES---LQHVIKAGLQT
KIRE-AKDKVQINVVKLVAMLKSSTDI-SPEVDVRLKAEESLKEIESYITRAEQLLGQRE
SPGGLISKYKEALIISNTKSLTKYLKAVGDLKNNATEDVRLSLEEKSSAICAKWEFLHHE
LSLYIQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEDGILY
QLHQHMDVLRELCKE-LT--SQKSQQEVQRALKDYEQKIERLLKCASEIHTAL-----QP
TMG-GT--SKTEGTTTTSENRGRDFHSEGPFVKSDHQPSAEK---A-VEPITDFNLASEL
KPQQEESITEKCEKAHSASINTLLERYDTHKEILELHLQNNTFRITSDFSTEKERSSSCL
QDKLTDLQ-ILKTETDACWKEFEITSSKLENLVSDKKKP-FVVKDRDRLKGKEGELQMTL
NARMESLETALQIVLPVEKETLLLCGSD-LPLQEMSIQEFYLIDADGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNNL-EESGNFVLKKLH
PLDLHAMQNIILKCKTQLEEMNHKVQAIGDALKALEDFLAPLRTSKLPIKLG-TGHLASD
TQVTSENTLSVKNKEEEIHLMKGNARHLDERLKKLDMSLKDAERGENTSCEKLFDAVSVQ
LFETRGCVVQEELTEGNKLLEA-------CVFKNNELLKNIQDVQNQISKIGLKDPTVPA
VTHRKKLLIQLDKDLDEYEEEKKHLQEMANSLPQFKDGREKSLNQQCQNTVLLWENTKAL
VTECLEQCGRVLELLKQYQNFKNVLTTLIQKEENVISLQASYMGKDNLKKRIAEIEVVKE
EFNEHSEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANIIVDRWLDINEKAEDYYENLG
RALALWDKLFNLKNVIEEWMGKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSGRLPE
IQFLLQSSEIPLELQVMESSILNKMEQVKKCLTGESNCSTLSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHNMTLLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLSDQCKNFNDWFSNIKMNLKECFEPSETKKSVEQKLQKLSDFL
ILEGRSSKIQQVDTVLKHVKKHLPKAHVKELTSWLAGQEFELEKMESICQSRAKELNDCL
QQLLRLQDDHRNLSKWLTNQEEKWKEMEESGEKAELFCQGFTRKREQFESLAQLNNSLKE
YGL-TGE-----EVITESTCLIDRYQTLLRDLGEIEEEDKLPPAEDQSFNDLADDVIHWI
TEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIETVMQQAE------GSASPL
A--QKTLTDISNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLQEKKAQLKIYRKFLKKAQDLTSLLKQLKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQICVTDLNTTLDNISKEFVSFSDKPVDQTAVEEK
L-QKLQELENRLSLQDGTLKEILALAKSIKQNTSSVGQKI-IKDDIKSLEC-KQKDLENR
LESAKQEMENYLKSIL-RSGCSTEK----KEKF-TLLGREKQTTSDVQESTQKSGAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVETIMSKQLSLDVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLKEIEELYTQLEAKKAAIEPLEQTECLRQTETSALVFHNTRYSVYHLDNL
LQALITLKKNKEIQYCLLKDFQEHLTAVESSIKALLTEKESLK--GPLDSVTYLDKIKNL
LSSIEKEKGSLGKLKIEWENLSNHATDMDKQLLEIQIKQLERGWEQVEQLVLKKYSQQVV
EYDEFMSLVNKMQDIENSL-Q---QHEQCLQLRLNSPEQ-EGNQSMIALATQLEATKHRF
SVLKGQAELQMKRIWGEKEKKILEDAINNLKKQLEAL-KPLNLEVE-----NQIEKCDIR
RKVKETMLWIKNLLSELITPISLLPDDILSQIRKCKVTHDGILERQQAVQSLVEEVKGNI
PSLTAHEGDDLNNLVEDLQKQYQMLVLKSTQRSQQLELKLEERSRFFAIITKVRLALQGK
ETPIIPKVETTS-PEAELVPHLTALKASQKELQEIESVISTHLQELTNIYEDLNVFERLF
LDDQLKNLKTRVNRTQRFIQNKCKEIEHKVNFYREFHERTSMLQKEVDN--IQHNEL--L
LQ----EIDQGVKEEIYNLKDRFISIQHSILQVLKLKELFDCIGLNWDGSQLD---QLQI
QVFEKEKELEGKIKQLETFEAEHGKYQTSLGKMRAMNLQIKKKAEEVLKASDTSP-ESNP
FNAQILNQRIEKTKYLYDDILKNLNENKAFDDSFKEQEIVQIKQNAEENDKLQKVL-QNM
ILQFQPKEMDEKNFQDKLENTIHVLNQIKSQLQQPLLINLEITHIENEKDNCEAFQEQVQ
AEIYSIKAVTPVEKQRE-ESSS-EASDVETKLRAIEELQMQLSTSIDLRTNALNDAYENL
THYDEEVTRALEIIASLEAIIASHRVDLDNPEESLEMPLRK-QEELESTIADIQDLTEKL
GAISSPEAKLKLQCTLQEIVSKNSAMKEAVKVQKADIQ--GYL------ENYQCYKKMED
KICTNLSKMEAVLGQSMSSLPASYKEALEHLEHSKALVSNLISIKEDLMKLRQALRHLRP
RCTEDDGVCLLRTLSALWAKWLSLLEATKEWEMWCEELKREWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSDVLDCLRQYQESVEKQQLALNLLLQRIKSIQNVPESLWAVE
T-VPAYQEITSMQERCNKLFQKAQKNKELIQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MALQDYPEKAEEFEELQSILRKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDVDEKISNEVLKSSPSYVMNRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVHDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATLKME
EYSELLKSTEAWIESTSRLLANPADYDSSRKLSHHASALQMA-LEDSEQKHNLLHSIFAD
LEDLSVIFETDDLTQ-SIQGLSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSVEKKV
SKIKTVLL-SKEIFDFSPEEHLKHGE----------------------------------
-VILEHIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVIQEQNEL
LKV-TIKQTNECDEEIERLKDTLNNYSAEFSLGHMSPDQAANLPQVQG-EMESMEKQILS
LNQKKEDLLVDLKATVVNLQQHLKQEQEAAE--REMLSAVAP-EDGGMAER-DASEWKV-
--NRRGSMSFLAAVEEEAEEGSLKSESGDKKVEPPSRS--WPVLWKHDKDM-EEDRA-SS
SSGTIVQE----ADGKISTCDSSMAQILMPDSLNTE---QGPEFSL-PNQTEEGATPPVK
AAALDFSDEQG-DFEATV--EKSRPETAEVLHACKSQVARLEQWLQQANVAFEPETLNAD
MQQVVEQELAGCQAMLTEIEHKVAFLLDNCKDQGLGDGGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--HPPILKKP--S--EHQKVLQPVNLSELESIVTERPQFSRQRDFQ
QQQ--VLELKPMEQKDLIQFIEFN-AKKRWPQYCQHDKDT-TQESSV----------SNQ
ASSPENDVPDSVLSPQGQ-TGNKWQY-----L-HHELSSKIRLPLP-QLVEPQVATNKSI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEANNLQTQETMTEETYINLDKKLFELFLTLS
QCLGSVEEMLQTPGLFKEDVSAQQVHC----ETLALELKKLYLAMSDKKADLLKAMTWPG
KNTSLLRECFDNLQVCLEHTQATVASRSKSLKAGLDYNHSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIGKQLQKADAHTVELQNSESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGILGARYTELSSPFITETQQDALLQGLVELVNIGKEKLVQDHLQQTKSKVALQAQIQ
NHKVFFQKLVADMLLIQTYSAKMFPSLLQKRETFWAEQITEVKLLEEKSRQCGMKLQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLLERISFYQQIKRNIHGKHARLCQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSSKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSREAITEMISW
MNNVERQTADEDSAHPPDSVSQVKNLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITENENKIQILNNWIEVQEE
RLKMLQKPESVVSVQKLLLDCQDIENQLAIKSKALDELRQSYLTLES-GAVPLLGDTASR
IEELFQKKSSVISQVNQLKTSMQPVLQEWKSYDKLYDEVNMMTIRFGYCMEHSKPLV--L
SLEALRCQVQNLQSLQDEAESSEGSWEKLQEVVAKLKVLC-PSVAEIIEEKCQDTH--TR
WTQVNQ---DVADQLQKAQSLLQLWKAYSSTHAEATAKLKQQEAKFQQLANINMSGNNLA
EILPPALQSIK-ELQRDVQKTKEAFLQNSPLLERLPQ-PTECSTHMLLPGHLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDQLESLKGHI-MHEEENLNSLYHQEK--EENPDSFLN
HVLALTAQSPDIEHLNEVSLKLSLSDVAVKTLQNMNRQWVRATATAL-ERFSELQGIGLN
-EK-FLHYCEKWVQLLEKMEEMLKVNIADSLPALLEQQKTYEMLEAEVSVNQTIADSYVT
QSLQLLDTTEIETRPEFVSEFSKLTDRWQSAARGVRQRKDDVDELVRRWQYFT-TSVE-D
LLRFLSDTSHLLSAVKGQDRLSLYQTRSLIHELKTKEIHFQRWQTTYSLTLETGEKLLH-
-TTNPETKESIHKRISQLQDNWKDTELQLAEMIKQFQSIA-ETWDQCGKKIKVLKSKLQV
LKAQSKNPLPELHEDLHNEKELIKELEKSLANWTQNLKELQTMKADLTRHILVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGEQLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAAGPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLMEEELEELHRY
CQEVFGRVSRFHRRLTAH-PGLEDEKEASENETDVED--PREIRTDSWCKRGENEE----
PASPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQMEGDRDRPPIPSDSSTPYKPPYVKLLLTP---
--GKEG---PRVLNGSPQQ-EE-ERLAGGTG-PQ--SGAFDRWELIQAQELHSKFRTKPN
L---QQLNSDISDITTWLKKTEA-ELEMLKMAEPPSDIQEMGLRVKRLQEILKAFDTYKA
SVVSANESSKEFLQTESAESTE--LQSQLHQLSRCWDAAQGAADSWREGLRQSLMQCQDF
HQLSQSLLLWLASAENRRQKAH-V-TDPKADPQALLECQKELMQLEKELVERQPQVDSLQ
EISNSLLIKGRGEDYIEAEEKVHVIEKKLKQLLEQVSQDLMSLQGRQNLDP-SLPG----
--LN--EAD-TGD-QPPAASVPAPHAKKFRG-----ERTTEGEKET-----------ESR
VPG-GARPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

--------------------------------------------------QREFTQKKTF
TSWINSILAKHTPPYVVSDLYTDIQQGHLLLDVLEVLSGQHLPREKGFNTFQCRSNIENA
LTFLKSRS------LKLINIHVADIIEGKPSIVLGLIWTIIFH FHIE----ELARTLACT
YNQ-----PSPDCPSAVD---SSPKANRSAKKSAK--IKERWKMSAT KALLLWAKEQCSL
-HGSV-SVTDFKSSWRSGLAFLAIIQTLRPGLVDLEKAKVRSNKENLREAFRIAELELNI
PRLLEPEDVDTVNPDEKSIMTYVAQFLQYSKNLPESEEDMQE-KVREAV--------GWL
AEQEKKLAKLLVETEDETYCQKYKE----MMSFMETFNQEKIPFLPVLSSKRGEAELSGG
QQQMREEWDKVISQMNEWKVKLDQMLPSPLGSIEAWLQEVERLQAEDLPDLQDPFKAMSV
FREIIVIFKGLMECFDSHLDTLQSFKNEDEKNMPLVLPEKLEEMK-RRL-----------
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---------------------------------------------------------IKE
KICTHLSQMETVLGQSMFPLPVSYKEALERLEQSKALGSNLTSTKEELMKLRRVHRHIRP
MCTDSDDVCLLRTTSALWDKWLSLLEAAKEWEIWCEELKREWKSVSEEIEREAIILDNLQ
EDLPEISKTKEAATTEELCELLDCLCRYQENVEKQQLLLTLLLQRLRSIQNAPQSLQAVE
T-GPAFQEITSMQERCNKLFQKAQENKELVENETQERHSFTKEISTLKNLFQQTATSFQN
MELHDHPEKAEQFEELQSIFKKGKLTFENIMEKLRIKYSEMYTLVPAEIESQVEECRKAL
EDIDEKISSEALKSSPSYTMRRKIDEINKGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKAILKME
AYHDLLKSTEAWTENTSRLLANPADYDSSKMLSQHASTLQMA-LEDSEQKHNLLHSVFTD
LEDLSIIFETDDLAQ-SVQELSRQVAALQQKIMESLPQIQRMADDVVAIETEVKSMDKKV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDVKLLENVTQEQNEL
LKM-VIKQTNECNEEIENLKQILNNYSAEFSHEHISPDQTANLPQVQG-EIEGMEQEILS
LNQKKEDLLVDLKAAILNLHQHLQRDQQELE--QEMPSTGTS-EEEGVAER-EGSEWKL-
--NK-SSMSFLPALKEEAEESSLKSENGEKTAERSSGS--WSLLCKHDQDM-EEDRA-SS
SSGTIIQE----ATEKISTCENAMAQVLVPDPVNAE---QGPEFSLSPNQTEEGATRPLK
AAALGFSDEHG-DFEATV--EKPGLKPADILHACKTQVAELELWLHQANVAFEPETLNAD
MQQLVEQQLVGCQAMLTEIEHKVASLLESCKDRGPGDSGATHQEAEALSLKLKTVKCNLE
KVQIMLQEKYNEDQ--HSATLKKP--S--EHQNDLQPDNLSELEPVVSERPQFSRQKDFQ
QQQ--VPELKPTEQKDFIKFVEFN-AKKIRPQFCQPDKDT-TQKSSE----------SIK
ASSPAKDAPDSVLSTQGQ-SGDKWQY-----L-RHELSSKIGLPLP-QLVQPQVATNMSI
LPSVSVYNFRYPTTEELKTYTTQLEDLRQEANNLQTQENMTEETYINLDKKLFELFLTLS
QCLASVEEMLQTPGLFREDVCARQVHY----ETLALELKKLYLAMGDKKDDLLKAMTWSG
KNADLFHECFNNLQVYLEHTQATAASRSKSLKAGLDYNRSYQNEIKRLYDQLTKNKTSLQ
QSLNEISGQSIDEQLQKADVYTVELQNSETRVAKLRDEGERLRLPYVLLQEVYKLEDVLD
SMWGILRARYTELSSPFITESQQDALLQGMVELMAIGKEKLAHDHLKQPKSKDALQAQIQ
NHKLFFQKLVADMLLIQTYSNRMPPSLLQKKDTFWAEQIQEIKLLEEKSHQRGIKLQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGRELVASVSCPELEGQIAKLEEQWLALNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINSFFEFSKELDDKSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTTLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNDVEHQTADEDCEHSLSSASQVKNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRMHGTLNRKIQHLEQLLESITETENKIQILNNWMEAQEE
RLKTLQKPGSVISVHRMLLDCQDIENQLASKSKALDELRQCYLTSES-GTMPLLEDTASR
IDGLFQKRSGVISQVNELKTSTQSVLQEWKIYESLYDEVATMTIRFWYCMEHSKPGL--L
SLEALGCQVQNLQSLQDEAESSETSWEKLQEVIRKLKDRC-PSVAEIIEEKCQNTH--AR
WTQVNQ---DIAEQLQKAQSLLQLWKAHNSAHTEAAARLEQQEAKYQQLENINMSGNNLA
EILTRALQDVK-ELQDDVQKTKEAFLQNSALLDRLPQ-LTESSTHVPLSTQLHSLQRVSY
LEKMLLVKANEFEFVLSQFKDFGERLESLKGLI-THEEEHLDKLYHQEK--EENPELFLN
HVLALTAQSPDVEHLNEVSLKLPLSDIAIKTLQNVNRQWIRATATAL-ERCSELQATGLN
-EK-FLYCCEKWVQLLEKTEETLKVTMADSLPALLEQQKTYEMLEAEVSISQTVADSYVT
QSLQLLDTTEIEKRPEFVSKFTKLKERWQSAAQSLRQRKSHIDGLVGRWRHFT-TAAE-D
LLRFLANTGPLLSAAKSQDCHSLPQTRRLIRELKSKDIHFQRRHITYALTLEAGEKLLN-
-TASLETKELIDKKISQLQDNWKDTKLQVGEMITQLQSNI-ETWDQCEKKIKELKSRLQV
LKAQSRDPLPELHEDLHKEKELIKELEKSLANWTQNLKELHTLKTDLTQHILAEDVMVLE
EQTEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADLSI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAVLRRLRHFTNQREEFEGTRESVLVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSRAPGLEDEKEASENETDMED--PREIQADSWRKRRESEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISEDHS------
------------WHVPDSPSCPKHRYKQMGSDRNVQTIPSDSSTPYKPAYVKLLLSPGT-
DGGKEG---ARALNGSSQQ-ED-EGLAALTG-QQ--SGAFDRWELIQAQELHNQLRMKQN
L---QQLNSKISDITTWLKKTEA-ELEMLKMAEPPSDIHEMELRVKQLKEILKAFDTYKA
LVVSVNMSSEEFLQTESAESKE--LQGRVGQLALHWDAAQGAVESWRAGLRRALVQCQDF
HQLSQDLLLWLASAESRRQKAH-V-TDPEADPQVLLECQEELMQLKKELVEREPQVNTLQ
ELSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLMSLQGSQVSPL-VAFK----
--YVWYQMP-TGK-QNGR-----PRCG---A----QAI---ST-WS-------EWRLEVP
GPG-SSRPRRSFLARVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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-----------MNSPEQQD-DE-TGLGQLAD-ADQQTGTFDQWELIQAQDLQNKLRLKRN
LKQWNRLNSELQVVTAWLKKAEG-ELEEFQKSEPATSLQEIERQVKKLKDILKAFAGYKA
SLISVNLSSEEFQQGESSESKE--LHNRLRQLNLHWEKTSRAADSWREGLRRSLMECQVR
RADGSP---WPALRP-------------ALGAQGL-------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

-------------------------------------------------AEQEHTQKKTF
TCWINSQLAKHNPPSVITDLFTDIKKGHVLIDLLEVLSGQQLAREKGSNTFQCRSNIEHA
LTFLKKRS------IKLINIHVADIVEGNPSIILGLIWTIILH FHIE----ELAWILSCN
YNQ-----PSLDCVSVV-D--LSQTSGPPPKKRSR--AQARWKMSAKKALLLWAQEQCTM
-HGY -VNVTDFKSSWRNGMAFLAIIHALRPDLINMDSVKGRSSRDNLKEAFRIAEHELNI
PRLLDPEDVDVINPDEKSIMTYVAQFLQYSKDLPVAGDEVQE-KVKDAT--------VWL
ISQEKKLHELQMESEKETYFKKSQS----MRVFLESFNEEKKAFLDVLSIKRNAAGLTND
QSRLREAWDKLTNQINEWSAKLDQILPPPLDQIEVWLQEIEHLMAEDLPDSQDYSQAMVL
IKERINSFKSLMDDFDPHLNNLLSFENKDEQCLPMVPPDKLEEMK-RRF-HNIMGINFIA
LLEFHYYLCSVLGLIEEVKSKLNIWNVKYGTQESVKLLLEDWHTFIEEKEFLIHLESSFQ
KCETM---IKN------LDGDPQNINKQFKMVESQISMCRKCIYDIKSTLQKVLSSWAIY
TENLQSLKTWLEESRKEHPKQ-----LPFETLASWNSVLSTVNEVGKFLIDVSNQEVGSS
INKELKRLNKRWAKFIKKTQFEMKLRF-I-QKQEQLSLENIGN----------TELPLEE
SLISYGDTIDISAETLRKHIQ--FLK----------------------------------
--------TGKESEDVIKEFTELLQMLEEMEEFIVQ------VATWETEIRPVLDFIKHQ
GYVE--ASMEESLQKLIARGSMYQEHVTKKENALQIIAQNISSKAL---LQHFHTSGLQT
QIKE-AKDKVQNNMAELDAVLQASYES-SLEMDVRAKFEKSQKELESDIIKVRQLLGQKR
SLGNLVSQKKDILAILNSKHLDKFLKAAEQLKNIVSPDEKLSLEEMSREFSKEWEVLYQE
IYLYIHRIKIEIEK-ELIENISKLEKQLNKEKKLLSKGKTKGLLEEHK--ACFSDEGKLC
QLDHYMEALRELSEE-LT--SEESRQEIRKTIIEYEQRQNGIKNTASEIYMML-----QA
LNE-NTQIFEKRKPSSASGNGGKDVEKMAQPSKPNDAASSEE---ASGSASFDLEYFSIL
KHHEDERHT---EKDGDVPFKKLLERYDAQRDNLEMQLQNNKVRVLSDFPSEKERSISCL
QDKLTDLQ-VLKNETDSCWTEFEMTSSKLEKIVRDPEKS-VLSRTRDKLKRKESELQVIL
SNRMKSLEAALKFVSPIEKEAILLSDSE-QLLHKIDIQEFDLTGVDAAYQNLKD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------SSIAKQIELCSNL-EHPGSDVLNEFN
PVDLHATQSIIVKYKMQFEEMNHKLQNTEIALKALEDFLASLRKAKLSIQPA-TDSSTSD
VPVVQENPWTVEKIQKKILLMKGEARCLDQRIKMLDISLKNAECGKDTCCEKLIEIFSKM
IEETHGHNEPEDFTEENQLLEV-------FIAKNNEILKNIKYIQDQINKIGLKDPTVPA
VKQRMKSLTKLEKDLDYYAGEINYLQKMASSLPQLKDGKGENPSQQCQETTCLWEDVKSS
VEECLEQCQRAMDLLKQYQNCKSILTSLIHKEESVISLQASYMGKENLKRRIAKIETVRE
EFNKHSEDVEKINQICKNLQFQLNKMITFEEPPFEKEANVIVDRWLDINEKTENYYDNLV
RALALWEKLLNLTSIIDEWIEKVLRKVEVHQLNDTEKTQLQEELKIQEQNSAKFGIRLAE
IEDLLQISEPPLELQVIKSSLLNRIEKIKMHLMDKSNPSELSGSTAELKEDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILHQKLNMTLLENQIGCLTPELSELKKQYESIN
DLFSTKKRTLQDHFFNLLNDQCKNFDDGFSNIQLSLKECFEPPDTKKSVEEKLQKLKDFL
TFEGRNKDIQQVETALNNVKKHLPKASVEQLSNWIMNQELELQKMKFTCETRAKGLQDCL
QQLLRLQEDYISLNKWLMNQEEKWKEAEVE-NKRNFFCQALTRKRQLFESFAQLNNSLIK
FGL-LR-----EEIVIESTHLVEEYETFLTQVCEIEN-HQSPTAEDQSFEDLVHDVFSWI
MGIKESLMVLNSTEGKMPLEERIQKIKEIILLKPEGDVKIQDIMSLGE------KSKAPL
V--QDTLSDIKNQWDHTILLANTYLSHQEKIQLEGEKYLQSKDDLRLMLTELKK-KQESG
FALQNGLQEKKAQLKIYKKFLQKAEDLTSLLNELKTQGNYLLECTKNPKFSEEKWLEVKH
LHESLLHQLQDSVSKLEGHVQEHQLYQDLVADLSTTLENFL--YFYFEDKSQSQISTSDT
LGHKYQELEALVNLKGDTLDKILALAESIKQNSSSVGQKI-IKDETDSLKC-KHKDLENR
LESVKQETENSFNNIL-KSKSEMKK----KEKI-VMKKIEEQLSSNTQDSVQGSITVEKL
KERW--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EANK--NSGIEMLLSKQLFPEAQESMKNIEDERRVSELQNQPL
ELDIISANEQLKEIEVLYGQLEAKKANIESQESIILPSDTETMALDVQNVQHSLDQLDRL
LQTLVTLKEDKERQYSLIKDFQEHLLAVTSSMKALSMEKESIKA-ASLESIQHLNKLEKC
LKLVDEEKDSLNKLKEEQVNLVGHLNDMDKKLAESQIKQLELCCEQVEEGIQKKYSQQGA
EWDELQCLIGKIQDMENSL-Q---EQQQQ---KLNSPSQQGENKGPVPLATKLQAIKDNF
SLLKGRAEHQMKRIWGKKEKKTLENAINNLQEQLEAL-EPSTAEKD-----SQLRSCLTM
KKIQEAVLWVNNLLIGLEQTAALLPDNIVSQIRKHKTVHDEVLDKQPIIESLVKETKDAV
PDLILCEAADLNIFSQELQNSNQALISKCSEMSQQLESKMKERSTFFEKMGKIQGSLQGK
EVLIVSETKTT--SKEDLDHQLVTLKDSQKELQMMEGVISSHLQEATDFSKNLNVFERVF
LDDQLRNLKNKARRTQRLVQNKCHEVTKKLDTYTELLEKTNMLQQELNE--IHSHELL-L
NG----EMNQGTKEEICELRERISVLQSNVLQIVKYKELFEYLGLNWDSSQFD---KVQE
ELLKIKTKLEEKTKQLERVIAEKERIQTSLNELKIVTLQIKKEIDEIVNDPNFSP-ESSL
LRAQILSQEVEKATCLCQETIDMFNANEILKESFKQ-ELSQIKLLAEENDKLHKSL-QNR
VENFHPQSVSEKDFKDQLEHALHVLTQANFQLHQPLHLGLEIKHIQEEKNNCELLQKQVM
AELCHIKSITVKEYPRQEDNPH-ETRDLETKLNEFEDLQLQFNTGIALRMNILDEALKDM
KHYNEAVTRTVGVINSFEAAVDSHKIELDNLGKFQQLIVWK-QEEFEVLIADLKNLTSKL
ENIASPEAKVHLEHVLSEFINKNALVKESAETKQADLE--RSL------KCYQSYNKIKQ
NICANLNKVEKELQQSISHKPMSYKDALERLEQSKNFVLELVSTQEELMKLRQDFRCLKL
MCTENDSICLLKIVSALWEKWLSLLENAREWELYCEELKQEWKFVSEEIEREAIILDNLQ
EEFPESTKPKEAATNEELSEVLECFCQYEENLEREQLLFTLLLHRIKNILSVPENLETSE
S-IPVLQEILSMQDRCIKLSQKAQANKKLVQLEIEERNNISNEIIALRNAFEKVTSSFHD
MELEEDPDKEEHLEALRRIIDKEKLALENIMEKLRIKYSEMYTIVPAEIECQMEECKKTL
EDIDEKIRNEVLKNSPSYVMSRKIEEINHGLQNVEKMLQQKSKNIEQAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMVPFQQYQQVSQRAEHRTSQLNKATLKME
EYNDLLRNTETWVENTSSLLDGPTDYSSSKTLSHHANILQMA-LEDSEQKQNLLHSVYSD
LEEFSMIFETDDLAPIKLNQLSARVTTLQQKLMASLPQIQHMADEVVAIETEVKSIEKKV
SKIKAILF-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIKPMKKSIAEIESYQVVLQLPETGMKSLPVFERTNQLSQEVKMLEKMTHEQNEL
LKL-VIKQTDECDQEIEHLKHQLKNYSAEFSSENISPDQTAILPQVQR-EIDNIKEQILG
LNQKKKDLLMSLKTTVLALHQRLQQEKQELE--KE------S-EESGVTER-DDSEWKL-
--KRKGSMFLPPSIVEEIEESSQKSENGEEKAE-SSSP--WLLHWKHERNK-EEDRA-SS
SSGTLIQE----ADGRISTYDGYNTQISVPNLLKNE---QNLESSPSHTQEEAGDTACIR
APAENSGEEES--LEETV--ASSRPESVDILHVCQKQVAELELWLDKANLSIGAEILNPE
MQQMVEQELAGCQAMLTEIEHKVSSLLENCKDQGLGNSGSTQQEAEMLSLKLKAVKCNLE
KVQVMLQDKYNEEQ--RSNTLKKP--L--EDQKVCQSDRFPIFESTEFESPLFSRQKSFQ
PQE--PSELKPGEQKDLIKFIEIN-AEKMWHQLDQQDDCK-TQESLE---------SP-G
TSHSRNGSPASFLPSQEQ-SEDKWQY-----L-LQELSKMKLP-LP-ESVDDQITTNVNF
LPMVPLHNVKSPTIEELKTYTSQLEDLSQEANALYTQENLTDETSVNLSKKIFDLLLGIS
QCLSIVEEILQTSGLSREDAIVQQAHY----ETLSLVLQKLHSTITNKKDDLLKLINHPG
KNSSVFFECFNNLQTRLEQTRTAAASRSQSMKSGIDHNSDYQNQVRQLYDKLIEKKSSIQ
HSLNDISSQSISEQLQKADLYAVKLQDCEVQVAKLRDEGERLYLPYVLIQEVYKLEDVLD
DMWGLLRTKNAELNSPFIRESQQEGLLRGLAELVNIGKEKLGQDQQQQVKNKASLQVQLQ
NHKVFFQKLVADVFLIQEYSKKALPCLLQNKEKFWEDKVKEIKLLEQQAYQYGTKLENLL
QEWKEFDENYESLEKDLEILGSSLPTTSLVEETEERLMERISFYQQIKRNIDEKHTKLYQ
TTSEGKHLATTVSCPELESQIAKLEEQWLALNKKVDHELHRLQTLLKHLV------SYNK
DSDELTKWLESAQQTLNYWKEQSLNVSQDLDTIRSNINDFFEFSKEVDEKSSLKTSVIST
GNQLLHLKEADTATLRSSLAQFEQKWAVLITQLPDIQEKLYQLQMEKLPSRKAITEMINW
MDSIEQQTVDEDTVDSPSSVTQVKNLLQKYKESRMEMNYKQWIIDFVNQSLLQLSTSDVE
SKRYERTEFAECLGEMNRQWHKLHGTLNRKIQHFEQLLESITENENKIQTLKNWMEAQGE
RLKTLQRPRSIISVRKTLLDCQDLENHLTTKSRVLDELKENYMALES-GPIPVLQDTISR
IDGLYQMRNNIVNQINQLKTSMQSVLQQGRGYDKLFEEVNMMTIRFWYCMEHSKPDM--L
SLEALRCQVNNLQLLQDEVENSEGNWSKLQDAISKLKDCC-PSVTEIIEQKSQEAY--TR
WTQVNH---EVTDQLQSAQSMLQLWESYTVAHAEATARLEQLEEKFKHILNINMSGDNLT
EILIRALKDAK-NLQHDLENIKETFLQNSAVIAPNLE-QAGPVKQDVLSNQSSSLQRISY
LEKMLLMKSNEFEHILSQLKDFRDQLESL-----EDSIKHSIESSNLQK--EDDPESVLN
DMLELTALSPDVEHLNEVSFKLPLSDIDIKTLQNLNRRWSQATATTL-EKCSEIQGTGFN
-EK-FLQKCEKWIQFLEKIEEYLKMKQAGRLEDLLEQQKTFEMLQAEIFVNQPIADYFVS
QSLQLLDSPEIEKRTEFVVKLTMLKERWQDATRRAQQRKITINERVKEWRRFT-ASLQ-N
MIHFLTDTDHFLSAVKSQDSYSLCQIRSLIHDFKNKEILLKRRQTTCALTLEAGRRLLV-
-IADPETKDSIDREIKELQDTWRNCQLQVAEKTKGFQSTI-ETWDRCEKQIKELESRLQT
LKAKIKNPLPEPYEELYKEKELIKELENSLSNWAQNLKELNIMKADVSWYILVEDVMVLK
EQIDHLHRQWEELCLRVSLRKQEIEERLNSWIVFNEKNKDLCAWLVQMENKVLQTADISI
EEMIERLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKTRVAEIDDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RSWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAEKTAAYPNSSEVLYTNAKEELKKFEAFQWQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQRRVTAILRRLKHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDVDDKMRQLH-GFQQEITLNTNKIDQLIVFGEQLIQKSEPMDAVLIEDELEELHRY
CQEVFGRVARFHRRLTSHNTGLEDEKEASENETDVED--SREIQSDSWHKKEVNEG----
PSSPQSLC----HLMPPPL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSAVSGKSISEAHG-----------------------------
------------WRTPDSPTHQKHCYKQTEVDRNVLPITPETSIPYEPEYVKQLIHPGM-
DNVDNG---REGPGMLNAS-EQ-KGLTD----TEQQAGIFDSWELIQAQDLRNKLRTKQN
LQQWQQLDSDINDVTLWLKGTES-ELEELEVAKPATDIQETELRVKKLKDILKAFDNYKA
LVVSINLSSKKFQQPDNTESKE--LQNRLRQLNLLWEKANHLLDSWRESLRHSLMQCQDF
HQLSQTLLLWLASAENRRCKAQ-V-TDPNADPHTILECQKELMQLEKELLEHQLQVSSLQ
EISKYLLAKRGGEDYIEADEKIHVIGKKLNQLLDQVSQDLESLRGSQDEDT-TLTA----
--FD--DVD-SSDHHLSLKSMPTAQE-TVLL----RKVEHLSD---------------PA
STV-ISSRPRSFLYRVFRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----------------------MQELETSLAGWTQNLQEVQALKAELGRCVLAEDVLLLQ
EQTEHLHRQWEDLCRRVSIRKQEIEDRLNSWAVFNEKNKELCAWLVQMENKLLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENE-LQLRQMGDHLIRASSKARAAEINDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCNNQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

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-------------------------------------------------RVFS-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFSICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKWG----FLP---AKYDG------
-------------------------------D----------------------------
---------VHTW--------FFFLPSQYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPSLEDEKEASENETDIED--PREIQADSWRKRREIEE----
PSCPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSALSDVEIPENPEAYLKMTTKSLKASSGKSISEGHS------
------------WHVPDNPSHPKHHYKAMEGDRTVAPVPSDASTPYKPAYVKLLLRQGT-
DDGKEG---TRGSKGSRQQ-ED-EQLDTLTG-QQ--PGAFDRWELIQAQELHGKLRMKEN
V---QQLNSDIGNITAWLEKTEA-ELETLRLAEPPSDIQEMALRVKRLQEILKAFDTYKT
FMVSVSESHKESLPNESPESTE--LQNRLHQLSLSWDTVQGVMDSWRADLRQSLMQCQDF
HQLSHDLLLWLASVESRRQKAC-I-TSPEADRQALLEAHKELT------VNRQAQVSSLQ
EIASSLLVKGHGEDYIEAEEKVHVIGKKLKQLREQVARDLMSLQGSLNPDP-SLAS----
--FD--EVD-SGE-QPLAAS-------QFGA----ERSAEEEEETD-------SRLPHLD
GPG-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QG-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPASSPPAKKCSK--VQARWQM SARKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQG-KVKDAM--------GWL
TLQKEKLQKLLKDSENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKRDLDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEI---YKN------LAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSVELPENYNQ--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DDVD--TSMEESLKHLIAKGSMFDELMARSEDMLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLIAALKNLTDV-SPDLDIRLKMEESQKELESYMMRAQQLLGQRE
SPGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TAG-GT--SKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK---A-MEPTMKFSLASVL
RPLQEESIM---EKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDARWKEFEIISLKLENHVNDIKKP-FVIKERDTLKERERELQMTL
NTRMESLETALRLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADRIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK
LSETHGYGVQEEFTEENKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLQC-KQKDLENR
LASAKQEMECCLNSIL-KSKRSTEK----KGKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQES
ETLIIPRVETAA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEADS--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRR
LNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVW
AEMCSIKAVTAIEKQR--EENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRK-QEELESTVAHIQDLTEKL
GMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAE--RYL------ENYKCYRKMEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNEWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-EIERMEKQILS
LNQRKEDLLVDLKATVLNLHQHLKQEQEGVE--RDRLPAVTS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTSDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
ADTLDSSDAQG-GLEPRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNAD
MQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHQEALQPVNLSELESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDNDT-TQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMGI
LPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWPG
ENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISI
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GAVPLLEDTASR
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI-MHEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT-TSVE-N
LFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGNPQQ-ED-GGLAGITE-QQ--SGAFDRWEMIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAKNRRQKAH-V-TDPKADPRALLECRRELMQLEKELVERQPQVDMLQ
EISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAS-PLPS----
--FD--EVD-SGD-QPPATSVPAPRAKFRAV----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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-------------------------------------------MEGQNFEALAQKMSSWI
KRLNESVIGLGSLEGELPLEERIHQIKEIIVLKDDGDSKMQNIIALGKILMNMEGATDCA
I--QQTISDLQNQWECTVDLATEYLSHQEQIQLQRKQYSQSKKDLRLVLTELKKQQQELS
PDVQAGLQEKQAQITNYIKLLQKAESLTFLLHELKSQGDYLKDCVEDSCFMEESWLELKH
LHESLLSQLQDLPQALEGYGQEYQEFQDTLAVLSSKLNRQCEEFCHFTDTSVEKPAAVQH
Q-LKLQE-QAPLSQCEDKLKKILALAESVEENTSSSGQKI-SKDAVETLQC-KHRSLKER
LKNVKQTGENSLRDTP-DSKHAFADETKTQDKSDKMIERENQVFSDTPTVVEENSRTEEL
EEDWKMDICQGLNGNVEDQEQQHNLYSEENRLLADSPNSPLKDQSKNIQ-----------
------------------------------------------------------------
--------------------------EQTVQHHKEKSSDGNNQAYRENVQQFQQWLCREE
QMLNSFTSEKERPSSKETVPILEGSNVEMAFQKQLLCEAQANAEYIVKEQKVSELKNQAA
ELDIVLVNEQLRELENLYTELEKQRATALSLRQDISPRSRERSTSNLQTTEDTVSCWDRL
LKELEAIKEVKQHHHHLVNDYLGNLSAVQSSMKILSTEKENIKT-GPVN-HIVLEKIKKI
MDSIQKERDVLNKLKTEQDNLSGHLTCIDKELTENQVKQLERWWEHIEQSVQKKHYQVVS
EIDEFNLLMNKAQDLQKLI-Q---H-QQRLQAELNPEDGQKNKCPLL-WTSELQAIKYSV
SLLKGSTELQMKRIWSEEEKKTLENSIHDLQNQLEVLA-HQIPQEDVWILVSDPKKYEIT
RRIKDNISWVKDSLFSLDQKAALFPDDITIQIRNCKAVNSEALDKETTLELLADETQSII
SDLNPEEVTYLSSLLQELQKSYQAFVLKSAQRLQQLEFQLEKRQRLIAEIQRVHSQLQNA
ETLTIPDINETS-TGSELGNLYGILKDLSKEIQESEDLISSRLQESQHSHGELNIFEQLF
LTDQLRCLKNRARKIQRLIQNKCHAVEKKVAIYTELSERITSLNQELND--LWCDILK-L
EGEEILSVKEEVKDKLNVLQKRIFDVQSSLLQIMKYKEIFDCLRLNWDTSHLD---ELQT
QFLEIKNKLEEKIKCFDNCVIESVRHQALLSEIQTMISNIKHEADMLTNSPGSSS-ETNF
VSAQILCQRVQQVRHLIQEAANQLNLNEVFAISLKKAKAQQIKSLEEDIDGLHQFL-QDI
ILDLQAEYANKQDFQSTLEHTLHTIKQIKSEFQQPLVVDLEMKIIQSEKMHCEAIQDWVQ
TEFCAIVDLMGKEREKQEPPSC-LIADVEAKLDELENLQIQLKTDIASRLNALDEAQEKV
KLYTEAVQRASDLLTEYEARILSAKVGLGSLQESCQIPHWK-LEEFESAKADIEDLSAKL
ENVITPRAKQQLKQTLSELVTKNSVLREKAQRRRADVQ--RYF------EKYSNYSKIKE
KICANLNKMEKILGQSLSSTPRSYKEALEHLEQSKVLVSQILSAEEDLMTLRRDSRDLSM
MCKGDGML--VQFVSTLWGKWLGLLEAAKEWEMNCEDQKQEWKFVNEEVERQSIILDNLQ
EELPESLKEKEKASTNALLELLDCVDCYKENMDREQLLLLLLLHRIRSILNVPESTERET
S-VPIRYEIHAMQDRCRKLSQKAQKHKNSIQSEIQERDKINEEINSVRMSLQNTSFLLCD
GESQDSTEKAAQLEEVQRIINRENQTIKDIMEKLRIKYSDMYTIVPADIETQLQGCKKTL
QDLEEKVTTRIFQNSPHYVINKKVENINNGLQAVEKMLQQKSENIAKAKEIQKAIWDMLD
LWHYKLNELDSEVQDIAEQDPCHSQEWMDSLMIPLQQYQLVSQRAELRTTLLNKANSKME
EYDELLKSMQHWIETTNGLLTAKAENNSAKALSKHASVLQFE-LEDSEQKQNLLHSIYSQ
LDELSVILETENIVQ-QINEVNGQVIALQQKIMEILPHIQHMADEVNVIESEVKIIEKDV
AKIKTILS-TEDILDFSPKEHLRNGL----------------------------------
-VILDHINRSKKTLAEIQGYEEGLRLPGMRMQPLLVFKRAAKLMKELKMLEKITKEQNVL
LES-FIKETDECEQEIEKLKQFLKNQLGELSNEKPLFPQTASCPE--G-EMEDIKEQIIK
LCQKKDDILTGMKSSILELHQHLQKEQPEPE--SELSKPLAPEETSLV-----GKDTSER
QMKKKGSMSLLPSLVEETEDSSFLS---EENAIVPPAESFWPSGKRDERDK-DDSGA-SW
SSGTLSDGIALDADVLPESCDKHSKETSFQVA-QKTGSDEDCAADLNNQAV-GDTPSSVT
NTGQCFQKKPG-ESKETV--DSNRPEPEKILHVCQAQITELELWLEKAKVSLESETQTPE
MQQMVEQQLADCQVMLSELEQKVVSLLEDCRDRQQGDSAVPQQEAEALSLKLKDVKCSLE
KVQVLLQDKYSEEQHNCE--------R--IPSELPQPGSSKVSNLITTDTPPLSRCKGLQ
QRQ--DLLLKPTEQNNLVDFIKLY-VEKM---QPHFADGA-TQKLDS---------SS-D
SSIPRSE--LADLFLRDQ-TGDKWQY-----L-QQELSATMKSPLC-QLADPQITTELNI
LPRGAICSIKTPTVEELKTYTMKLGDLSQEASVVQTQENVAGEASLNLEKKLFELLLAIS
QCLNNMEEMLNTCMFSNEEAAVQQVLC----ETLSLELQKLHADMREKKDDLLKSVACAD
GSTDVFVQCFNNVQARLELSQTAAASRSKSMKAGLDHSSNYQNEIRLLYDQLIEKKSALQ
QTLNTIRRHNIAEQLQKTDAYALELQNFETQIAKLRDHGEQFQLPMALVHEVYKLEDVLD
DTWGVLRAKYVELNSPFISESQYEGLIHGLAELLDIGQEKVAQDSKELAKNRATLQSHLQ
NHKDFFQKLVTHMFVIQSYSKKVGPATLQKNEKFWTELVEYVRSLEQKSSQYGARLEGLL
QEWTEFDEDYVTFTKELEALASTVPSVNLVEETEERVMERITLLQQIKRNIDEHHARLYQ
MVKEGKKLMTLVSCSDLVNQTGKLEELWLSLTNKVGHELHRLQMLLKLLV------SYNR
DSDKLTKWLESAQQRMNFWKEQSLDVSQDLDTVRNNIDSLFAFSKEVDEKSSLKSSVIST
GNQLLLVKQTDAAALRSSLAQFEQKWAELITQFPTIQEKLHQLQMEKLPSREAITEIMAW
LNHVEQQREEEAAVNLRSNASQVKNLLQKYKEYLMEMNFKQWMVDFVNQSLLQISTCDVE
SKRYERTEFAEHLGEMNLQWHRLQGSLNRKIQDLEHTLEIVTENENKVQTLSSWLKAQGE
RLKSLEKPASLISVQTTLEDCKELENQLTIKSKAIDQLKQNYMPLEN-GAEQTSEDTVVR
MDKLLEMRNGIISQVAQLKTSMQSVLQQWLIYDETYEEVNLMIMSSLYCLQQCKPPV--I
SLEALKHQVKILQSIQDKAEGNEESWAKFQASAANLKKCCCSSFAEIIDHKCKEAH--TR
WTLANE---EVNDELQATQALLQLWEHYDGLHSQAVLRLEQHEEQCHLLLGAHLPEDNMA
EVLKQKIQDVK-ILQQGLQPIKGSFLQVSELTDQIAQ-HAKAATQAVLSDKAHPLQRISY
LEKMLQMKSDEFKFNLLQLEDFKNCLDTVEAQI-KSPVEALDQLHAQGK--EDDSELLMS
HMLELAAMSPDIENLNEVSVKLPLSDFTVKQLQSLKRQWIQKTTAAL-EHFRTFEGIEAD
-EKKLLQKCKNWLQSLEKMKEALKVNISGRFEKLQEQQRIYEKLQMEISVNDQIFNSVIS
KGFYSLGTGEAEKRTEFISTITQLKEEWQGVIRRVQERKKDIDGLVKQWQHFR-VSQQ-N
LTNVLTCTSNFIAAVKSQDSYSLYHLRNLIHNLKNKEILLQRWQTTYSLAVNSGEKLLK-
-NTDQETSAVIQDELSRLQENWNDAQLQVEKITKQLLGTA-QTWDSCEKRIKELENRLRQ
LKAKIKDPLPDEDEELHKAKEHIKELEKSLAGWNQNVKELDNMKADLAHYILAEDVMLLK
EQVEHLHRQWEELCLRVSLRKQEIEDRLNVWSVFNEKNKELCAWLVQMESKVLQPADVSI
EDVLEKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKSSNKSRVAEIDDKLNKINNRWQHLFDVIGGR-------
---------------------------------------VKKL EGTFAV IQRLDKTMSNL
RTWLARIEAELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHSEGVESVFNICEALLSD
SDACANETECDSIQQTTRSLDRRWRNICSMSMERRMKIE ETWR LWQKFLEDYSRFEDWLK
SAERTAAYPNSSEVLYTGAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVAAILRRLKYFTNQRDEFEGTRDSILVWLTEMDLQLTNVEH
FSESNFDDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAILIEDELEELHRY
CQEVFGRVSRFHQRLTSRHPGIEDDKDTSENETDAED--SREIQNDPWHKKAINEL----
PSSQQSLC----HLVSPAP----AYERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDE----EEGTYYSALSDIEITENPEAYLNMTTKTLKASSGKSISEALT------
------------WHSPDSPTCRKHQYNQTEMLRNVQSGSPETSTPYKPGYAKLLVSASS-
GNMDSVKEASAVLNDEDPQ-ND-QGLVNIAA-AEKQSGVIEKWELIQAQDLRNKLRMKQN
LQQWQQLNSDLSDITAWLDKTEE-ELEELQKAKPATSLHAIEQRVKKLKNMLKAFDNYKA
LVFSVNLSSKDFQQTDSTESKE--LQNRLRQVNLRWEKVSHSMDNWRKGLKQTLMQCQDF
HELSQKLLLGLANAESRRHKAQ-F-TDPNSDPHTILECQKELMQLEKELLEQQLQVNALQ
EISTYLLVKSDGENYIEADEKIHIIGKKLKQLLEQVSHDLKTSQGNMDKSA-FLPA----
--AD--DLD-SGG-YHPLIVKSKPQE-MVGV----RRTSERKS--N------NSVRLENQ
QATQASSSPHSFFYRVLRAALPLQFLFLLFLLLACMIPSSEEDYSCTQVNNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLPTEDE-QV-SLGIDDLHI-----SLQ---------A-QEDTQKKTF
TCWINSQLAKHTPPSVISDLFTDIKKGHVLLDLLEVLSGQELPRDKGSNTFQCRINIEYA
LTFLKNRS------IKLINIHVADIIDGNPSIILGLIWTIILHF HIE----ELARTLSCN
YSQ-----TSLDDVSVV-E--SSPTSSPPAKKCSK--AQKRWQM SAKKALLLWAQEQCAT
-CES-VRVTDFKSSWRNGMAFLAVIHALRPDLVDMKSVKHRSNKDNLKEAFRIAEQELKI
PMLLEPEDVDVVNPDEKSIMTYVAQFLQYSKAAPRIREKTQV-KMKDAM--------VWL
PLQEKKLQKMLKDSENETYCKKYES----LLSFLELFNEEKKSFLDILSTKGNLDELNED
ELQLREAWDGLTYQINMWQTKLNDDLPSPLHQVEAWLQEVEELMDEDLPASQDNCEAIVL
MQEKMALFKSLMDKFDCHLNTLLVFENRDEKHLPLVPPYKLEEMK-RRI-NNISGKKFIP
LLQFHYYKYSVLGLLDEVKSKLDVWNVKYGSKESVELLMEDWHKFIEEKEFLAQLETSFQ
KCEEI---HKN------LGGEYQSISEQYMMLEDNISVYRKSIYNVKSTLQKVLTCWATY
IENLRLLKACFEETKKEQVKE-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXPKTHLEMKLPL-I-KIQNQPILDSSGN----------I-QLSKE
EKVTVDFSTDMSVELPENHNQ--NIK----------------------------------
--------AEEEHEKENGKSARQLNVAEEIEKLIGQ------VEIWEAEIKSVSDLLRHQ
GDID--TSMEESLQHLIAKGSMYEELVSRMEDTLQMDVQNISSQES---LQHVLKAGLQA
KIQE-AKERVQINMINLVAMLKNSTDV-SSDLDVRRKVEESLKELESYITRAEELLGQRE
SQSGLISKYKEALLIFNSKSLAKYLKAVEELKKNVTENVKLSLEEKSRDVCAKWESLQHE
MSLYIQQLKIDIEKGKLSDSISRLEKQINKEKKLIRRGKTKGLIKEHE--ACFSEEGSLY
PLDHHMVVLRELCEE-LT--SQKSQQEVRRVLRDYEQKIERLRKCASEIHMAL-----QP
T-G-GT--SKNKGSVNTSENGGRNAHSEAPSARSDNQPSTEK---A-MESIKKLSLESEL
KPQQEEN-TEKFEKDHNTSMNSLLERYEIHRETLELHLQNNKFRITADFPSDKERSSACL
QEKLTDLQ-VLKNETDACWKEFEITSLRLEELESDIKKP-FIIKVRDRLKEKESEFQMTL
NNRMESLEAALQIVLPVEKESLLLCGSDLLLLHEVAVQEFHLTDADGIYQNLRD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNNL-EQSGNFALKELH
PLELHATQNIILQHRGQLEEMNHRVQRSKDALRALEDFLASLRAAELSVELV-TDLSASG
SQVVPENTLTVKYKEGEIYLMKDKARHLDKRLKMLDISFKDAERGEDTSCEKLLDALSKN
LFETCGYGGQEELTEEDRLLEA-------CIFKNSELLKNIQDVHNQISKIGLKDPTVPA
VKQRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXLDQCERVLELLKQYQNFKSILTTLIQKEENVISLQSSYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLRDAIYEWTEKVLRKMELHQLTEEEREKLKEELQVYEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMETSILNKIEDVKMRLTGEPSCSALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNSIKMNLKECFESSETKTSMEQKLQKLSDFL
TLEERGSKIQQVETVLNHVKKHLPKAHVKELNSWIVSQEIELEKMESVCQLRAKELGDYV
QQLLRLQDDHRNLSTWLTNQEDKWKEIEESREKTELICQTLARKREQFESAAQLNNSLKE
YGL-TEE----EEIIAESTRLIDRYQALLRQICEIEEEDKLPPAEDQSFNDLVHDVIHWI
TGIKESLMVLNSSEGHMPLEERIQKIKEIILLKPEGDAKIQMIMSQAE------TSKVPL
V--SKTVTDIENQWVNTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLQEKKTQLKIYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLEDSVQKLEGHVQEHHTYQICITDLHTELDNFSKEFVSFSDKPVDQTAVEEK
L-QELQELENRLHLQDGTLEKILGLAKSIKQNTSSVGQKI-IKDDIKSLKH-KQKDLENR
LESAKQEMENYLNSIL-KSKCSTEK----EGEF-TLPGREKQITSDMQESTQDSAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMVLSKQLSLNVQESMKNTEDEQKVNELQNQPL
ELDVTLRNEQLKEIEELYSQLEAKKAAIEPVEQSEYFNKTETSALALHSTRNSVQHLDNL
LQALITLKKNKESQYCLLKDFQEHFAAVESLMKALLTEKESLKV-GSLDNATYLAKIQKL
LASVEKAKDSLSKMKIEWENLSNCLTDMDKKLLESQIRQLEHGWEQVEQLVQKKYSQQVV
EHEEFTFLMSKIQDLDISL-Q---QQQQCLQLRLSSP-EQEGTQSMVALVTELQTLKHRL
SVLKGQAELQMKRIWGEKEKKILEDAINNLQKQLEAL-EPLNRELE-----NQIKKCEVR
NKVKETILWVKNLLGELVPTISLLPDDILSQIRKCKVMHDGILGKQQAVESLVEEVKNNI
TNLTAHESDELNNLLQDLQSQCQMLVLKSTQRSQLLEFKLEERSRLVAAIGEVQLSLQGS
ETLTVPKMGTPS-TEAELEHQRVTLMTSQKELQEIESIISAHLQELTNICKDLNVFERLF
LDDQLKNLKTRANRTQRFIQNKCNEVEHKINFSRKFHEQTSVLQKELDN--IQHNELL-L
KQ----EVNQDVKEEFYSLKDRLTGIQSSILQLMKLKEVFDDIGLNWDCSQLD---QLRS
QAIEKEKELEEKIKKLDTFMKEYGKYQASLNKLRAMDLQIKKRAEGVLTASNTSP-ESRL
LSAQILNQRIEKAICLYHEIVKKLSENKAFGDLFKEKEILQIKPYAEENDELHRAL-QNI
ALESQPKEIDEKNFQDKLENSLHVLNQIKSQLQQPLLINLKIEHIQREMDNCEAFQGQVQ
AEMYSIKAVTVTEKQRA-ENSS-EASDVETKLHDIEHLYMQLNTSIDLRTNVLNDAYENM
THYNEAVTRAMGIITALEAIVAYHRVDLDNPEESLEMPRWK-REELESAIADIQDLTEKL
ESIASPEAKLQLQCTLQEIVSKNSALMEAATVKEAEMQ--RCL------ENYKCYGKIKE
KIGSDLIHMETVLGMSMSPLPVSYKEALECLEQSKALVSNLVSTNEELMKLRHSLRYLRP
RCTDNNGICLLRTVSALWEKWLSLLEAAKEWKMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLSQYEENVEKQQLLLTLLLQRIKSIRNAPESSTAVE
T-VPAFQEITFMRERCDNLFQKAQKSKELIQNEIQERHSFAKEIITLKNLFQQTTASFQN
MQLQDHPEKAEQFEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXISNEVLKSSPSYAMARKIDEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
FWHSKLNELDSEVQDVVEQDPGQAQEWMDNLMVPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKNTEAWIENTSRLLANPADHDSSKTLSHHASTLQMA-LEDSEQKHNLLHSVFTD
LEDLSVIFETDDLAQ-SIQELSRQVAALQQNIMESLPQIQRMADDVVAIENEVKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VLLENIHPMKKTIAEIMSYQVELRLPQTDMKPLPVFQRTNQLLQEIKLLENVTQEQNEL
LKI-VIKQTNECDEEIENLKQILNNYSVAFSCEHMSPDQAADLPQVQG-EIEGIGKQMMS
VNQKKEDLLVNLKAAILKLHQHLQQEQHEVE--KEMLPVGAS-EEDAVAER-DVSEWKL-
--NRRGSMPFLPAVREEVEESSLKSEKGDKKAEPSSVS--WSSLWKHDRDM-EEDXX-XX
XXXXXXXE----ATGKISTCDSSMAQILAPGSQSTE---QGPEFSLSPNQTEEGATLPIK
AVALGFSDEQG-AFEATV--EKPSPEPAEVLHVCKTQVAELELWLHQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCRDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQLMLQEKYSEDQ--HSTLLRKP--S--KRQKVLQTDNLSEFKSVVMERPQFIRQKDFQ
QQQ--VLELKPM-QKDLIKFIEFN-AKKMWPEYCQHDKDT-TQISSV----------SSE
ASSLENDAPKSVLSTQNQ-SGNKWQY-----L-NHELSSKIKLPLP-QLVEPQVATDVSI
LPSVSVYNFRYPTTEELKTYTAQLEDLRQEANNLQTQENVTEETYINLDKKLFELFLTLS
HCLGSVEEMLQTPGLFRGDICAQQMHY----ETLALELKKLSLAMSDKKDNLLKAMTWPG
KNTNLFPECFDNLQVYLEHTQATAASRSKSLKAGLDYNRSYQXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXKADAHTVELQNSEGQVAKLRAEGERLHLPYALLQEVYKLEDVLD
GMWGI-ETRYSELCSPSISESQQDALLQGMVELVKIGKEKLARDHLQQTKSKVALQAQIQ
NHKLFFQKLVADMLLIQTFSNKMLPSLLQKKESFWXXXXXXXXXXXXXXXXXXXXXXXXX
XKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVGSVNCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLLRHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKELDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQQWTILITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHKTTNEDSELSLSSASQVKNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTLQKPESVISVQKMLLDCQDIENQLAVKSKALDELRQSYLTLES-GTVPLLEETASR
IDGLFQKRSSVVNQVNEFKTSMQFILQAWKIYDNLYDDINMMTI-FWYCMEHSKPVV--L
SLEVLRCQMQYLQSLQDEAESSEGSWQKLQEVIGRLKGYC-PSVAEIIEEKCQDIH--IR
WTQVNQ---DIADQLRKAQSLLQLWKVHTSAHTEAVARLEQQEAKYRQLANINMSGDNLE
EILTSALRDIK-ELQHDVQKTIEAFLQNSTLLDRLPQ-PTESDTHVLLSGQQHSLQRASY
LEKMLLVKANEFEFVLSQFKDFGDQLDSLKGLI-MHEEENLDKLYQQEK--EGNPESFLN
HVLALTAQSPDVEHLNEISLKLPLSDIAVKTLQNINWRWIQAMATAL-EHCSELQEIGLN
-EK-FLYCCEKWVQLLEKIEEILKENIADGLPALLEQQKTYEMLEAEVSINQTVADSYVT
QSLQLLDITEIEKRPEFVSKFTKLKDQWQNATQGIRQRKREVDGLVRQWQYFT-TSEE-D
LHRFLADTSHVLSAVKSQDCYSLCQTRSLIHELKNKEIHFQRWQTTYALTLDTGEKLLN-
-TTNLESKESIDKRIRQLQDNWKDTKLQVGEMIKHFQSVI-ETWDQCEKKMKELKSRLHI
LKAQSEDPLPELHEDLHKEKELIKELEKSLANWTQNFKELHTMKTDLTQHILVEDVMVLK
EQIEHLHRQWEDLCLRVSVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINMFSENK-LQLKQMGDQLIKASSKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSIERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQHWDNLQKRVTAILRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHQRLT SHAPGLEDEKEASENETDMED--PREIQTDSWRKRREMEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASFGKSISEGHS------
------------WHVPDSPSCPKHRYKQMGGDRNAPPIPSDSSTPYKPACXXXXXXXXX-
XXXXXX---XXXXXXXXXX-XX-XXXXXXXX-XX--XXAFDRWELVQAQELHKKLRIK QN
L---QQLNSDISDITTWLKKTEA-ELETLKMAKPPSNIQEMELRVKRLKEILKAFDTYKA
LVVSVNVSSKEFVQTGSTESKE--LQERVGQLRLHWDAAQGAVQSWRESLRQSLMQCQDF
HQLSQNLLLWLASAESRRQKAH-V-TDPKADSQVLLERREELMXXXXXXXXRQPQVNSLQ
EISDSLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLTSLQGSQSPDP-SLPG----
--LD--EVD-AGD-QPPAASVPASHA-KVGA----ERTTKGENKTD-------SRAPGSA
DPG-SSRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHQR LTSLAPGLEEEKEVSENEADMED--PREIQTDAWRKEGESEE----
PTSPQSLC----HLVPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----E-D----EEGPYYSAV-----------------------SGKSISDSHS------
------------WHVPDSPSCAKHHYKQMEEDRSEPPIPSDASTPYKAPYVKLLLHPGT-
DGGKDG---LSTLNGSLQQ-EE-EQLASLTG-QH--SGAFDRWELIQAQELHSKLRIKQ N
V---QQLNLIISEITAWLEKTEE-ELETLKMAKPPSDIQELEPRVKRLREILKAFDTYKT
LMVSVNVSGKESLPPESAESTE--LQRRLCELSLHWEAVQGVMDSWRGDLQQSLMQCQDF
HQWSQNLLLWLASAEDRRQKAL-V-TDPKADHQVLLRCQKKLMHLEKELAECQPQVNSLH
EISTSLLTKGNREDYIEAEEKVHVIKKKLQQLREQVAQDLMSLQR----NP-ALPD----
--FD--EVD-ASP----VAFVSAPQAK-VRA----PSFWEN------------------C
AGY-FLKPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QG-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPASSPPAKKCSK--VQARWQM SARKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKI
PRLLEPEDVDVVDPDEKCIMTYVAQFLQYSKDAPGTGEEAQG-KVKDAM--------GWL
TLQKEKLQKLLKDSENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKRDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEV---YKN------LAGECQNISKQYMMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKASVEFSTDMSIELPENYNQ--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEVWEAEAKSVLD----Q
DDVD--TSMEESLKHLIAKGSMYDELMARSEDMLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLIAALKNLTDV-SPELDIRLKMEESQKELESYMMRAQQLLGQRE
SPGELISKYKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK---A-MEPTMKFSLASEL
RPLQEESIM---EKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDARWKEFEIISLKLENHVNDIKKP-FVIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADCIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPV-TDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK
LSETHGYGVQEEFTEENKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCENTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTALIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLD-------------
-----------------------------------------EELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKKSVEQKLQKLSGFL
TLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWLTNQEEKWKGMEESGEKTELFCQALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEGK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLQC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLTAQESMKNTEDERKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDSL
LQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASVEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGGDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQES
ETLIIPRVKTTA-TEAELKHHHATLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEVDN--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYVGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRR
LNAQILSQRIEKAKCLCDEIIKKLNENKAFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVW
AETCSIKAVTAIEKQR--EENSSEVSDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPVRK-QEELESTVAHIQDLTEKL
GMISSPKAKLQLQCTLQELVTKNSAMKEAFKAQETEAE--RYL------ENYKCYRKIEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMKERCNKLLQKVQKNKEVVQTEIQERHSFTKEIIALKNFFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNKLDSEVQDIVEQDPGRAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-EIECMEKQILS
LNQRKEDLLVDLKATVLNLHQHLKQEQEGVE--RDRLPAVTS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTSDNSMAQILTPDSLNTE---QGPECSLRPNQAEEGTTPSIE
AATLDSSDTQG-GLEPRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAVEPEALNAD
MQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGTTQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HLTILKKS--SEPEHQEALQPVNLSELESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-TQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNFQTQENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYDQLIKSETSLQ
QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE
NHK---------------------------------------------------------
-KWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVISI
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GAVPLLEDTASR
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PAESSTHVLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSRFKDFGVRLESLKSLI-MHEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVWQRKGDVDGLVRQWQDFT-TSVE-N
LFRFLTDTSHLLSAVKGQERVSLYQTRSLIHELKNKEIHFQRRRTTYALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GGLAGITE-QQ--SGAFDRWEMIQAQELHSKLKIKQN
L---QQLNSDISTITTWLKKTEA-ELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECRRELMQLEKELVERQPQVDMLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAP-PLPS----
--FD--EVD-SGD-QPPATSVPAPRAKFRAV----RTT--EG-----------EEETESR
VPS-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MAASPVLPTEDG-EG-FMGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----KLAQTLSCD
YNQ-----PSPEVVSVA-A--SSPTSSPPTKKCSKAQAQARWQWS AKKALLQWAQEQCAR
-SES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPGPGGSAQA-KVRDAL--------VWL
TLQEKRFQKMLKDSASETYCNKYHS----LLSFMESLNEEKESFVDVLSLKGRMGELNED
ESRLRQGWTSLMHQVAAWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTL
IQGKLSSFKSLMGSFDYHSDVLMAFQTNAEKSLPAVPPAKLEEMT-RRI-NNVLGKNFIP
LLEFHDSKCSVLALLDEAKAKLDVWNGTYESKESVEVLLEDWHKFTGEKKFLVQLDASFQ
KCEEM---YKN------SARECESIREEYIMLEKNVHSCRQYIHNTKATLQRALMSWATF
EEDLALLKASFDLTKKEQIKE-----VPVETLLQWNTKHTSLNEVGSFLIGVSSREVAAS
ISKELRRLNKRWRKFITKTPL-LKLPL-V-KIQDQPPGNSSGT----------S-L-SKG
--------SAMAAEPSGSRGE--DVK----------------------------------
--------AAEKQEVEDEESAGQLKVNKEVEGLIKQ------VTIWESQTKSILDLLQHQ
DHAD--GSSADTLQHLIAKGSVYEERLARTEDTLQMDVQSPSNLEP---FQNVLRAGLQA
KIQE-AKQGVQITMVELSAVLKNLSDE-PLELDLGLKVEEAQKELEVSISRAEQLLGQRE
RPGGLLLKYKEALEILNTNSLAKYLRAVEELKHTVPGGAKLQLEEQSRVASAKWEPLRHE
ISLYFQQLKIAIEEEKLRDNIARLEKQINKEKKLIRRGRTRGLRKEHE--ACLSPESIKC
QLEHHVGVLRVLCEE-LT--SPEDQQELKRALRDYEQKIARLLKCASEIHTTL-----QS
SQG-GA--LEERSALITTENGRRDADGEVPLEIPDNQLSTGK---A-MEPIKNFSQTSEL
KPQQEESIMEKEGKDCSASLSDLQERYDTQRGLLEQYLQDSKSRVTSDFASEQERSSACL
QSKLAELQ-VLQADTDAHWEKFEITSLNLRRLMSDSEKP-VLNQERDLLKGNEQVLHRLL
NTRMESLEMALQIVLPLEKECSLLCASD-LPLCTVAVQDLHPIETDSVYQNLRD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIRVCTSL-EEPSNSVPRELH
TLDQCAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASHRAAKLSAELP-ADRP---
APKAPE------VRSEDILLMKEKAGPLDERLRTLGISVKDAEGGENTTCERLVGALSVN
LVATDGQSKEEGPPEDKKLLEA-------CSFKNHELFKNIQDLQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWESTKAS
VTESLEQCGSALELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKIAEIETVKE
EFSDHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTGEYCENLG
RALALWDKLFIIKNNIDEWTGQILGKAESHELTEEDRGRLKEELKVLEEQSAEFSRRVAD
IQLLLQSNEKPLELQVMESSVLSKMKDVKTHVAGGSNSYAPSGNTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELSELKRQYASVS
NLFNTKKNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDFL
TLGGGNSKIQQVETVLQHVKMLLPKAHVKELDSWLRSQELELENMESICQAQAGELNNSF
QQLLRLEDDCRSLSKWLTNQEENWGKMEASGERMDLFSQALTRKREQFETVAQLSDSLKE
HGL-TEG----EETIKESTHLIDRYQALWRQLHEIEEEDKLPAAEDQSFNDLADDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAE------HCEAPL
A--QETFTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKK-QQEAG
FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKH
LHESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSTTLDDISKEYFSLCDGSKDQIMAKER
M-QKLQELESRLRFQGGALKKASALAKSIKQNTSSVGQKI-IKDDIRSLKY-KQKDLENR
IESAKQETENGLNSIL-KSKSSTEK----HVKF-SLPVEEMPATSGAPKPTRESAAVGES
GGARETNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLNVQESMQNAQDEREVNELQNQPL
ELDIMLRNEQLKGMEELSTHLEARRAAIELLKQSQHLNQTEEQASVLPTARPSVCHLGSL
QQELHTLKKTKERQYGLLSGFQDQLVVAEASLNSSLAEVESLKI-GSLDSATYLGKIKKF
LGSVENQQGSLSKLRTEWAHLSSLLAAADQKLVESQMKHLEHGWELVEQLAHRKCFQQAT
EHSELTCLLEKLQDLKVSL-H---QQQQRLTLSLNSPGQQAAIMDMVTPAAELQAIKCEF
SGLKWQAELHMKRLWGEKDKKTLEDAINNLNKQMEAL-EPLNREVE-----NRIKKCELQ
NRIKETLSWVKNTMAELVVPIALLPDNILSQIRKCKLIHDGILGNQQAVELLVEEVRGIT
PSLAACEGDGLNVLLKDLQSQHQALLLKSTQRSQQLELKLEEKSKLFAIIGKAQLTLEES
ETLMSPTGDRTS-TEAELERRLAILKASQQQLQDTESELSAHLQELTNAYKDANVFERLF
LDDQLKNLKARTNRTQRFLQNNCSELKHKIESYREFHDKAAVLQKEVEC--ILHGGLLPL
HQ----ELEQDAKEQLGNLRDKLAAIRGSLSQVLTSEEVFDTIGLSWDGSLLA---QLQT
QVLEREREVEEKIKQLDTFLMARDRHQASISKIRAVDLQIKKGTESLLKVPSMSP-ESTL
LNAQTLIRKIEKSKRLRDEIIRKLSKNEAFDDSFKESEMQQLKLCAEENSGLQEAL-QNM
LLELQPREMGEKEFREKLENALHVLKQIKSRLQQPLCVNLGVQHIQHEKETWEAFGEQVE
AEMCGLRAVRIAGEQKE-ENDS-GTGGMEAKLRDIEGLHMELSKSIGLRADVLNDAYDSA
NRYDELVAGASRIVTSLEATLLSYRVDLHNPQKTLELAHLK-QEELQSSVADLRSLTETL
GAISSPEAKEQLHCTLEALAAKNSALKAGLEAQEADEE--RCL------ENYKCFRKMKE
EICSRLKKMEMDLGQSIFSLPRSYKEALARLEQSKALTSNLLSTKEDLVKLRQLLRHLRC
RSTENYATCMLGVASALWEKWLSLLEAAREWQQWGGELKREWKFISEEIEREAIILETLQ
EDLPEISKTKDAAPTEELWQLLDSLCQHQESVEKQQLLLALLLQRVRSIQNIPEGTKTGE
T-IPALQEIGSMQERCDRLLQTTRKNKDLVQAEIQAQQSFLKEIKDVKRVFEQISTSFPN
LAPEGHPEQAEQFEELRSILHKGKLSFGSIMEKLRIKYSEMYSIVPAEIGSQVEECRSAL
EDAEEKMSSEVSKSSPSSVMRRKIERINNGLRCVEKMLQQKSRNIEEAHEIQKKIWDELD
LWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYSDLLKSTEVWIEKTSRLLANPACYDSSRTLSHRASTLQMA-LEDSEQKHSLLHSIFTD
LEDLSIIFETDDLIQ-TIHELSDQVAALQQQIMEALPHVQQVADDVVAIESEVKAMEKKV
AKIKAILL-SKEIFDFPPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVFQRTSQLLQDVKLLENVTQEQNEL
LKV-VIKQTAECDEEIDSLKQMLTNYSAEISPEHVSQNQVAHLPSLQG-EIERLEKQILN
LNQKKEDLLVDLKSAVLNLHEHLKQEQQEVGDKPSA----GA-SECT--ER-DASERKL-
--SRTNSMSFLPVVKEEAEESSVKSEDGRRRTEPPSAS--WSLLGKHSKDL-EGDGASSS
SSATIVQD----ADGRISTCDSSMVHIIAPDSGSTE---EGPAPSPRLSQTDEGATPPIE
AALLDFPREQG-AFESTV--ERSRPRPADILRVCKTQVAKLELWLQQANVAFEPETVDAD
MQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGATQQEAEALSWKLKTVKCNLE
KVQMVLQEKFSEDQ--HPSTLKKP--S--EPHDVDQPASLSELDSVLTERPQFSRQKDAP
QPQ--ILELKPSEQKDLIKFTELN-AKKTWLQGLQENEDA-NRQSAS----------SSN
VPSPGNAASDSTLPPQAQ-SGDKWQY-----L-HHELTSRPNPPVP-QLVEPQMALTTST
LPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEETYISLDKRLFELFLSLS
RCLGSVEELLQRPGLLREDACAQQVFF----QKLALELKKLYLALGDKKDDFLKAVTWPG
KEATLLPECIDALTVSLESVQSRAAWRDASLKAGLDHSRSYQNEVKRLYSQLIKKKTALQ
QSLNEISGQSIGKQLQKADVHTAELQNSEKQVAKLRDEGERLRFPHGLLQDVYKLEDVLD
SMWGILRARYLELSSPFLSKSLQ-TLLQGMAELVSIGKGKLATDPLQHAKSKAALQAQLQ
DHKAFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSLL
QKWEEFDDNHASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQ
TLNEGKQLAASVSCPEPEGQIARLEEQWLSLNKRIDQELHRLQTLLKHLL------SYSR
DSDELTRWLETSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISW
MNAVEPQAAGKDVELSKSSASQVKHLLQKLKEFRMEMDYKQWVVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEE
RLKMLQKPESAVSMEKLLLDCQDIENQLALKSKALDELRQSSLTMDG-GDVPLLEDMASG
IVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAV--L
SLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASC-PSMAGIIEEKCQDAH--SR
WTQVNQ---DLADQLQEARGQLQLWKAPHNAHEEAAAWLQQQEAKFQQLANTNLSGDNLA
DILPRALKDIK-GLQSDLQKTKEAFLENSTLLDQLPQ-PEERSTPGLHSGQRHSLQTAAY
LEKMLLAKSNEFEIVLAQFKDFTDRLAYSKDLI-VHEEENLDKLYHEEK--EEVPDLFLN
HVLALTAQSPDIERLNEESLRLPLSDVTIKTLQSLNRQWIRATATAL-DHYSALQENGWN
-EK-FLHCCERWIQVLEKIQESLSVEVAHSLPALLEQQKTYEILEAEVSTNQAVADAYVA
QSLQLLDTAEIEKRPEFVSEFSKLSDHWQRAARGVLQRKCDIGRLVTQWRFFT-TSVE-D
LLRFLADTGQLLSAVKEQDCYSLCQTRRLVHELKSKEIHLQRWRTTYALALEAGEKLRD-
-TPNPETREFVDGQISRLQESWKDTELSLGEVISQLQSTA-ETWDQCKKKIKKLKRRLQA
LKAQSEDPLPELHEALHEEKELIKEVEKSLANWTHSLKELQTMKADLSQHILAEDVTVLK
EQIQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSI
EEMIEKLQ-----------------------------------------------KDCME
EISLFTENK-LQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDNQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIED--PREIQADSWRKRRESEE----
PTSPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISEGHP------
------------WHVPDSPSHSKHHYKHMEGDRTEAPVPTDASTPFKSDYVKLLLRQGT-
DDIKEG---LKEAQ----Q-ED-EQLATLTG-QQ--PGAFDRWELIQAQELHSKLRLKQT
M---QQLKSDISSIAAWLGKTEA-ELEALKLAEPPSDIQEIALRVKRLQEILKAFDTYKA
LMVSVNVSHKEYLPSQSPEATE--LQNRLHQLSLSWDSVQGVLDSWRGDLRQSLMQCQDF
HQLSQDLLLWLATAESRRQKAH-V-TSPEADRQVLLECQKDLMRLEKELVARQPQVSSLR
EISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLQEQVAQDLMSLQGSLDPDA-SLTS----
--FD--EVD-SGE-QLPAAFAKSPRPRWTFL-----EEEEEEEETD-------SRTPHLD
----SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSTVLTSEDE-QV-SLGIDDLQI-----SLQ---------AEQEHTQKKTF
TCWINAQLAKHAPPSVITDLFTDIRRGHVLLDLLEVLSGQQLPRDKGSNTFQCRTNIEHA
LTFLKNQS------IKLINIHITDIIEGNPSIILGLIWTIILH FHIE----ELAQTFSCN
YNQ-----PPLDCVSIV-D--SSPTSSPRAKKCSK--AKARWQMSA KKALLLWAQEQCAM
-YES-VSVTDFKSSWRNGMAFLAVIHTLRPDLIDMNRIKHRSNKDNLKEAFRIAEQELKI
PKLLEPEDVDVINPDEKSIMTYVAQFLKYSKDTSGIGDKTEG-NVKDAL--------VWL
ALQEKKLQTVLKDSENETYFKKYES----MLAFLESFNEGKKPLLGVLLIKRNADELNEE
ELQLEKAWDNLNHQINEWKAKLNYDLPSPLQETEAWLQEVERLTGEDLPTSQDYSEAMTL
QQEKMTPFKSLMGKSDCHLNTILAFENRDEKHLPLIPTKKLEEMK-RRI-N-ILGEICIP
SLEFHYHMCPVPGLLNELKSKLDVWTIKYGSKESVALLLEDWHKFIEEKEFLAQLETSFQ
KCEEM---NKH------LAGEYMNISKQYMMVDYIIHMYRKKIHNAKCTLQKDLDCWSTY
VEKLHLIKACFEEAKKEQIKE-----IPYETLSQWNVEHATLNEVGNFLIKVSNDEVGSS
ISKELRRLNKRWRKFITKTQLDMHLPL-V-KKQNQAILDSSGN----------I-QLSTG
EKSTIDFSTDMSIELPGNHRQ--NLK----------------------------------
--------VGEEHEKENEELTGQLKVVEEVEKLTRE------VEIWDAEAKSVLDLLRHQ
DDVE--SSMEESLQHLIAKGSMYEELVARTEDTLQMDVQNISSQES---LQHVVTAGLQA
KIQE-AKEKVQINVVNLVAVLKSSTDV-SPELDVRLKVKESQKELESYITRAEQILRQRE
NPSGLISQYKEALVIVNTKSLAKYLKAVEELKKNVSEDVKLSLEKKSKDACAKWELLQHE
MSLYIQQLKIDIEKGKLNDSISKLEKQINKEKKLIRRGRTKGLIKEHE--TCFSEEGSLY
QLDHHMDVLRELCEEQLT--SQKSQQEMRRVLKDYEQKIEKLRKSASEIHRTL-----QL
VAG-GT--SKSKGTMNTSENGGRDAHSEVPFAKSDDQPSVEK---A-KELIKDFTLESEL
KPQHEES-MEKYEMDHNASINSLLERYDTHREILEQHLQNNTFRITADFSSEKGRSSDGL
QDKLTDLQ-VLKKETDACWKEFEIISLKLENLVTDVKKP-VIAQARDRLKGKERELQMTL
HSRMESLETALQIVLPVEKESLLLFDLD-LLFHEMAIQEFHLTDADGIHQNLMN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNNL-GQSGNIAFKELY
PFDLHAIQNIILKCKAQLEEMNYKVQRSDDALKVLEDFLASLRTL--STELV-TDPSASD
TLVAPENNLTVEDKEGEIQLIKDKARHLDKHLKMLDISLKDPERGESTSCEKLVDVLSVK
LFGAYNCGMHGKLSEEDKLQEI-------CILKNNELLKNIQDVQNHVSKIGLKDPTIPA
VMQRKKSLITLNMDLDEYEDEKKHLQEMANSLPQFKGGRENTLNQQCQNTVLLWENTKAS
VTECLEQCERVLELLKQYQNIKSVLTTLIQKEENVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEDVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEEYHENLG
RALALWDKLFNLKNVIDEWTEKVLRKVELHHLTEEEREGLKEEVQVQEQKTSEFCRKLAE
IQFLLQSSEIPLELQVMESSILNKMEHVKMRLAGKSTHSTLSSSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSNLLNDQCKNFNDWFSNIKMNLEECFETSETKTSVEQKLQKLSDFL
SLEGKGSEIQQIKTVLNQVKKHLPKSHVKELNSWITSQEFELEKMESICQVRAQELADYL
QQLQRLQDDHRNLSKWLSNQEEKWKETEESGEKTELFYQTLAKKREQFESLTQLNNSLKE
YGL-TEE----EELITESTHLNDRYQTLLRQLCETEEEDKLPPAENQSFNDLAHDVVRWI
TEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIQTIVSEVE------SSKAVL
V--QQTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPCLEIKH
LHESLLQQLQDSVQKLEGHVQEHHLFQVCITDLNTTLDNISKELFSFS---VDQIAVEEK
L-QKLQELENRLHLQDGALEKILALAESIKQNTSSAGQKI-IKDDIKSLDC-KQKDLENK
LKSAKQETENCLSGIL-KSNYSTEK----KEKF-TLPDREKQVTSGVQESTQNSAAVEKL
EESW--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EINK--NSAVEMILSKQPSLDVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLKEIEKLYTQLEAKKTAIEPLEQTEYLNETETSALVFDNIRYSVHHLDTL
LQTLVTLKKNKESQYCLLKEFQEHLTTVEFSVKALLTEKESLKV-GPPDSTTYLDKIKNL
LASAEKEKGSLNKLKTEWETLSGYLTDMDKKWLERQIRQLVHGWEQAEQLVEKKYSQQVE
ENDEFRSLMNKIQNTEISL-Q---QHQQCLQLRLNSPGEQEGNQSIVSLVTELQAIKHRF
SILKGGAELRMKRIWGEKEKKTLEDAVNNLQKQLEAS-EPLNLEVE-----NQIKKCKIR
YKMKETILWVKTQLDELFHTISLLPDGILSQIRKCKVTHDGILDKHQVVQSLVEEVKDNI
PNLAECETDDLNNLLQDLQNQYQTLVLKSAQRSQQLEFQLEERGKFLATVEKVQLSLQGN
ETLIIPKMETTP-TEAELEHEQVVLKASQEELQEIESIISIHLQKLKNFFKDLNVFERLF
LTDHLKNLKTRAIRTQRFILNKYDEVEHKIKFYREFHEKTSVLQKEVDN--MQQNELL-L
NQ----EINADIKEEFYNLKDQLMAIQSRILQLLKLKEVFDFIGLHWDCSQLE---QLQT
QVFEKEKELEEKIKQWETFVAEHDRYQASLDKVRTMDSQIKKRAEAVLRTPSTSP-ETSL
LNAQILNQRIEKAQCFYHEMIKKLSENTAFDESFKEKEILQIKLYAEENDKLQKVL-QNM
LLKFQPKKMDEKTFQDKLEDSLHVLNQIKSKLQQPLLTNLEIEHIQNEKDYCETVQEKIQ
AEIYSIKAMTV-EKQKEKENSS-EDSDVETKLREIEDLQMQLTTSIVWHTNVFNDAYENM
TRYNEAVTRAMGIIAALEARIASHRVDLDNPEESLAMPCGK-QEELESTIADIQALTEKL
ETISSPETKLQLQHTLQELVSKNSAMREAAKVEEAEVE--RCL------ESYKCYGNIKD
KICVNLSKMEKVLWHSMSQLPVSYKEALERLEQSKALVSNLLLTKEELMKLRQILRHLRL
RCTENDGISLHRTISALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCLYEENVEKQQLILTLLFQRIKSIQNVPDGLGSVE
T-VPAFQEIASMQERCNNLFQKAQKNKELVQTEIQERHSFKKEIITLKNLFQQTMTSFQN
MALQGHPEKAEQFEELQSVLKKEKLTLENIMEKLRIKYSEMYTIVPAEIASQMEECRKAL
EDIDEKISNEILKSSPSYAMSRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
VWHSKLNELDSEVQDVVEQDPGQAQQWMDNLMIPFQQYQQVSQRAEWRTSQLNKATVKME
DYNDLLKSTEAWIENTSRLLTNSADYDSSRMLSHHASTLQMA-LEDSEQKHNLLYSIITD
LEDFSIIFETDDLAQ-SVQQLSSQVTALQQKIMESLPQIQQMADDVVAIETEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQGKLRLPQTGMKPLPVFQRTQQLLQDIKLLENVTQEQNEL
LKI-VIKQTNECDEEIENLKQILNNYSAEFSLEHMSPDQAASLPQVQG-EIRDMEEQILS
LNQKKEDLVVDVKAAVLNLHQHLKQEQ-ELE--KEMQSAGAS-EEDRVDER-DVSEWKL-
--NRKGSVSLLPAVEEEAEESSVQSKNGDKKAEPSSSS--WALLWEDDKNK-EEYRA-SP
SSGTLIQG----AT------------------------------------------PPIR
AAALAFLAEQR-ALGPRW--RTLG------------------------------------
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----MVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLD-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHRR LTARTPGLEEEKEASENETDMED--PREIQADAWRKRGESEE----
PTSPQSLC----HLMPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAV-----------------------SGKSISDSHS------
------------WRVPDSPSPAKHRYKQMEEDRSEPPIPSDASTPYKQPYVKLL-QPRI-
HGGKEG---ARVLNGSHQQ-EEEQQLASAAG-QQ--SGAFDTWELIQAQELHSKHRIK QN
M---QQLNSVISDITAWLEKTEA-ELEALKMAKPPSDIQELELRVKRLQEIVKAFDTYKT
LMVSVNVSAKESLPSESAEASE--LHHRLCQLNLHWETAQGKMDSWRETLR QSLL QCQDF
HQRSQSLLLWLASAEEQRQKAL-V-TDPKADHQDLLRCQKQLMQLEKELAERQPHVNSLH
ELSTSLLVKGNGEDYIEAEEKVHVIKKKLQQLREQVARDLLS LQRSQ-VNP-ALPD----
--FD--EVD-SGD-QPPAASAPAPQAKQFLA----EGITEDEDNSD-------GS-----
----STKPRRS FLSRVIRAALPLQLILLLLLLLACLLPASEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

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------------------------------------GKEMLAHGHLKQAKSKVALQTQIQ
NHKVFFKKLVANMLLIQTYYDKMFPSVLPKRERFWAEQVTEVKSLEGKAQQFGMKLQSLL
QKWEEFDENYGSLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDLELHRLQTLLKHLV------SYNR
DSDELTKWLESSQQTLNHWKEQSLNASQDLDTIRNNINNFFEFSKEVDGKSSLKTAVLST
GNQLLHLKETDTASLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNSVEYQAAGEDSAHFPSSESQVKNLLQKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNKKIQHLEQFLESITENENKMQILKNWLEAQEE
KLKTLQKPESVISIEKVLLDCQDIENQLAIKSKVLDELRQSYLTLES-GAIPLLEDAASG
IHKLLQKRDNVTRQVSELKSFMQSVLQEWKLYDKLYDEVNMLAIQFGYCMEHSKPVV--L
SLEALRCQVQNLQSLQDEAEISEGSWEKLREVIHRLKDSC-PSVAEIIEEKCQDTH--AR
WTQVNQ---DLADQLQEAQTLLQLWKVYRSAHVEATARLEQQEAKFQQLANINMSGNNLA
EILPVALQDIK-ELKQEVQKTKEVFLQNSILLDRFPQ-PAESNASGLFSGQLYSLRRAIY
LEKMLLVKANEFEFVLSQFKDFENRLESLKGLI-IHEEENLDKLYQQDK--EENPGSFLN
HVLALIAQSPDIERLNEDSLMLPLSDMPLKTLQNMNRQWIRATATAL-DRCSELLESGLN
-EN-FLHCCEKWVQLLEKIEEMLKVNIANSLPALLEQQKAYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIEKRPEFVLEFSNLTDHWQSAAQGIRQRKSDIDQLVRQWLYFT-SSME-D
LFRFLTNTSHMLSAVKDQDCYSLYQIRSLIHELKNKEIHFQRWQTTYALTLEAGEKLLN-
-APNLEAKESMNKRIRQLQNNWKDTELHLAQMIKHLQSII-ETWDQCEKKIKELKSRLQV
LKAQSKDPLPELHEDLHRERELTKELEKSLTNWTQNLQELHTMKGDLTRHILSEDVMVLK
EQIEHLHRQWEDLCLRVATRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASSKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRHFTNQREDFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASETETDMED--PREIQTDSWHKRGESEE----
PSSPQSLC----HLVPPAL----SHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQMEGDRNVPPIPSGSSTPYKSAYGKLLLHPGT-
DGGKES---PRQ---------EDEHLATLTG-QP--SGAFDRWELIQAQELHSKLRMKQN
M---QQLNSNISAITAWLGKTEA-ELETLKMAKPPSNIQEMEPRVKRLQEILKAFDNYKA
LMVSVNVSGKESLPTESTEATE--LQSRLRQLGLRWEAVQGAVDSWRGDLRQSLMQCQDF
HELSQNLLLWLASAENRRQKAH-V-TTPKANRQVLQECQKELMQLKKELVERQPQVNSLQ
ELSTSLLVKGHGEDYIEAEEKVHVIQKKLKQLREQVSQDLMSLRGSQNSDP-SLLN----
--FD--EVD-SGD-QPSAAAMALSS------------------------------VGRMS
GPG-SSRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MAHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHQRLTSHVPGLEDEKEASENDTDMED--PRDMQTDAWHKSEENEE----
PSSPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAL-----------------------SGKSISDGHS------
------------WHVPDSPSCPKHHYQQMDDDRNVPPIPSDSSTPFKPAYVKLLLRPDA-
DGDKEG---SEVLNGNPQQ-ED-EPLTALTG-QA--SGAFDRWELVESPELHSKLRIKQN
M---QQLSSDINTITAWLAKIEA-ELETLTMAKPPSTIQEMELRVKRLQELLKAFDTYKA
LMVSVNVSCKESLPTESTESTE--LESRLRQLKLRWEGVQSTVDSWREDLR QSLMQ CQDF
HQLSQNLLLWLESAEKQRQKAH-A-TNPKADHRTLQDCQEELMQLEKELVERQPQVNSLQ
EIASSLLIKRQGEDYIEVEEKVHVIEKKLKQLREQVAQD LMSLQGSQNPDL-SLPD----
--FD--EVD-SGD-QSPAAL-PATQAKQLRA----------------------VRTEEKE
THG-SAQPQRS FLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MVHEGNQRWDNLQRRVTAVLRRLRHFTTQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHQR LTTPGLRAAREKEVSENEADMED--PREIQTEAWRKGGESEE----
PTSPQSLC----HLVPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----E-D----EEGPYYSAV-----------------------SGKSISDSHS------
------------WHVPDSPSCAKHHYKQMEEDRSEPPIPSDASTPYKVPYVKLLLNPGT-
DGGKDG---PSALNGSPQQ-EE-EHLASVTG-PH--SGAFDRWELIQAQELHSKLRIKQ N
V---QELNLVISDITAWLEKTEA-ELETLKMAKRPSNIQELELRAKRLQEILKAFDTYKT
LMVSVTVTGKESLPAESAETTE--LQRRLCELSLHWEAVQAVTDSWRGDLRQSLMQCQDF
HQRSQNLLLWLASAEERRQKAL-L-ADPKADHQVLLRCQRKLMQLGKELAERQPQVNSLR
EISASLLTKGNRADCAEAEEKVHVIKKKLQQLREQVAQDLMSLQR----NP-ALPD----
--FD--EVD-AGD-QPSVASMSAPQAQ-LRA----EGTMEDEDE---------------S
DSS-SSKPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

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----FFQKLVADMFLIQTYSNKMFPSLLQKKEAFWAEQVKEVKLLEEKSHERGMKLQSLL
QKWEDFDENYASLEKELEILISTLPSVSLVEETEERLMERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPQVEGQISKLEEQWLSLNKKIDHELHRLQTLLKHLV------SYNK
DSDELTEWLESSQQTLNYWKEQSLNVSQDLDTIRSNINTFFDFLKEVDKKSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIRW
MTSVEHQTADEDSVLSPSSASQVKNLLHKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRLHGTLNRKIQHFEQLLESITENENKIQILNNWMEVQEE
RLKTLQKPGSVISVQKTLLDCQDIENQLAIKSKALDELRQSSLTLES-GTMPLLEDTASA
IDDLFQKRNSVLNQVNQLKTSMQSVLQEWKIYDKLFDEVNMMTVRFWYCLEHSKPVV--L
SLEALRCQVQTLQALQDEAESSEGSWEKLQEVIGKLKNSC-PSVAEIIEEKCQDTYTSNR
WTQVNQ---AISDELQKAQSLLQLWKAYGSAHAEATARLEQQEAKYRQLASISMSGNNLA
EILTPALHDIK-ELQHDVQKTKEALLQNAALLERLPT-SAESSPDVLLSGQSHSFQRASY
LEKMLLVKGNEFEFVLSQFKDFEDHLESLKGLI-MHEEENLDKLYQQEK--EENFDSILN
HVLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERSSELQGIGLN
-EK-FLYCCEKWVQLLDKIEEMLKVNMASNLQALLEQQKSYEMLEAEVSINQTIADSFVT
QSLQLLNTAEVEKRPEFVSKFTMLKDQWQSAAQRVHQRKGDIDVLVRQWQYFS-ASVE-D
LLRFLTDTSHLLSVVRSQDCYSLYQTRSLIHEFKNKEIYFRRRQTAYALTLEAGEKLLS-
-VTDLETKESIDKKIRQLQDSWKGTELQVGEMIKHFQSLV-ETWDQCEKKIKELKSRLQA
LKAKSKDPLPELHEDLHKEKELIKELEKSLANWTENLRELHTMKADLTQHILVEDVMVLK
EQIEHLHRQWEDLCLRVAMRKQEIEDRLNSWIVFNEKNKDLCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINTFSENK-FQLKQMGDQLIQASNKTRAAEINDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAVLRRLR LS VIQKTWFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLT SRTPGMEDEKEASENETDMED--SREIQSDSWRKRGENEE----
AASPQSLC----HLVPLAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSHPKRHYKQMEGDRNVPPIPSDSSTPYKPAYAKLLLPPGT-
DGGNEG---PRVLDSSPQQ-EE-EGLAGLTV-QQ--TGAFDRWELIQAQELHNKLRIK QN
L---QQLNSDISDISAWLRNTET-ELETLKTAAAPSDIQEMELRVKRLKEILKAFDTYKA
LMVTVHESSKESLQTESAESKE--LQNRLHQLSLHWEAAQGAVDSWREGLR QSL MQCQDF
HQLSQSLLLWLASAENRRQKAH-V-TDPKADPQALLECQKALMQLEKELLECQPQVDSLQ
EISTSLLIKGHGDDYIEAEEKVHVIGKKLKQLLEQVSQDLMSLQRSQNLDP-SLPG----
--FD--GVD-SSG-QHPAASVPATQAKVG-A----ERTTKGKNETD-------SRVP---
GPS-SSRPQRSFLSRVIRA------------------PSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWAIDNLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLTRHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILH FHIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQMSA KKALLLWAQEQCAT
-YES-VSVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENKDENHLPLVPPNKLEEMK-RRV-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTIDSSGN----------I-L-SKE
EKATVEFSTDTSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIRQ------VEIWEAEAKSVLD----Q
DNVD--TSMVESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATVKFNLASEL
KPPQKESIM---EKDYSASVNSLLERYDTYRNILEHHLQNNKFRVTSDFSSEEDRSNSCL
QAKLTDLQ-VIKKETDACWKEFEIISLKLENHVSDIKKP-FIVKERDTLKERERELQMTL
NTRMQSLETALQLVLPVEKASVLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRAAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLDALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELHKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTALIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQLCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMIMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGCSAQHLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQIEQQIQKKYSQQVV
EYDEFTTLMNKIQDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDTR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRQCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLILKSTQRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVALEASQKELQEIDSGITTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFHEKMSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRG-EEKSSEASNVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESLEMTLRK-QEELESTIAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKARKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSAVWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVLESSGAVE
T-VPAFQEITSMQERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNSFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNEYDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EEGGVAER-DASEQKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTV---QGPECSLRPNQTEEGTTPPIE
AATLDSSDAQG-GLEPRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSALESIVTERPLFSRQKDFQ
QQQLQVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDT-AQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADRYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVPQDLDTIRSNIDNFFEFSKEVDKKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMICW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHHVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSGVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLV
EILPPALQDIK-ELQHDVRKTKEAFLQNSSILDRLPQ-PVESSTHVLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKVEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVWQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQECFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDSWKDMEPQLAEMIKQLQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPHSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENEVDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-ERLAGATG-QQ--SGAFDRWALIQAQELH-KLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPAP-PLAS----
--FD--EVD-SGD-QLPTASMPAPRAKFRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MATSSALPTEDG-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVISDLFSDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIIEGNPSIILGLIWIIILHF HIA----ELARTLSCD
YNQ-----PSLEVVSAA-D--SSPTSSPPPKKSSKEQAQARWQL SAKKALLQWAQEQCAL
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMDSVRHRSSKENLKEAFRIAEHELKI
PRLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPCTEASAQA-KVKDAM--------AWL
TLQEKKLQKMQKDSASETYVNKYHS----LLSFMESLNEEKEPFVDVLSPKGSTKELDED
QLQLRGAWLSALFQIAAWKAELDEALPSPLKETEAWLTDVEELVEEGLPTSQNYSEAVPL
IQEKMSLFKSLMGSSDYHSNILLTFENQDESRLPVVPPDKLEEMK-RRL-NTILGRKFIL
LLEFQASKYSVLALLDEAKGKLAVWNVTYETEESVAVLLEDWRKFIEEKKFLAQLDNSFQ
KCEET---YKN------LGRECESVKEEYVTLEKNVHLCRQHIHNTKATLQRVLTCWATY
KEDLPLLKASFEATKKDQIKE-----VPFETLSHWNTKYTSLNEVGSFLVEVSSGEVGAS
VSKELRRLNKRWRKFIPKTPLELKQPL-R-KIQDQTTGNGSGT----------I------
----LSEASAVPAEPHESHDG--DMK----------------------------------
--------AVEKQEDE--ESMGQSKVNEEVEKLLKE------LRLWELETKSILGLLRHG
DDVD--GSLVDTLQHLIAKGSMYEELLARTEDTLHMDVESVSNLES---FQNVLRAGLQA
KIQD-AKEGVQITMVELSALWKNLSGE-SPEQDVRLQLEEAKKNLESYIMRAQQLLGQRA
HPGGLISKYKEALEIFNTNSLAKYLQAVEELKHHAPSDEKLRLEEQYRDACAKWEPLHHE
ISLYIQQLKIAMEEGKLRDNIAKLEKQINKEKKLLRRGKTRGLIQEHE--VCFSPESVAH
QLEHHVGVLRVLCEE-LT--SPESQQELKRALRDYEQKIERLVKCASEIHMTL-----RS
SQE-DA--LEERGALTTTENGRRDAHSEALLEIPENQPSTEK---A-MEPLKNFSQTPEL
KPQQEGS-IVEKEGKDCKALSDLWERYDTQRETLERHLQDNKSRLTSDFPSESEWSSACL
QGKLTDLQ-VLRADTGACWDDFEVTSLNLESLVSDMEKP-ALAQARGLLMEKEQALRRLM
NPRMESLELALQIVLPLEKECALLCGLH-LPFCTVSVQDLHPVEVDGIRQNLQD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAQQMRICAHL-EEPSDSVPRDLH
TLDQRAIQDIVLKCRLQLETMNQKLEMSEATLEALEDFLASLRAVKLSVESP----ADPP
TSNAQEGTP------EDILLVTEKAGPLDERLRMLGINVKDAEGGENTTCQKLLGALSVK
VSDSHGQSKQEGLTEDTTLLDA-------CSSKNHELLKNIQDIQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLNGLEEEKMRIQKMVNSLPKFKDGKEKMVIQQCRDTAALWDSVKAA
LTDCLEQCGSVLELLKQYQNFKNNLTALIQKEEGIISQQASYMGRDNLKKKVAEIETVKE
EFNEHLEVVDKINQICKNLQYHLNKMKTFEEPPFEKEANAIVDRWLDINEKTEEYGENLG
RALALWDKLFNLKSSIDEWTEKILGKLESHELTEEDRERLKEELNVHEEQASEFSRRMTD
IQLLLQSNEKPLELQIMESSVLSKMRDVKRYVTGESNSCMPSGSTAELREDLDQAKTQMG
MTESLLNALSPCDSLEIFTKLEEIKQQILQQKHSMTVLQNQIGCLTPELSELKRQYASVS
DLFNTKKSTLQDHFSTFLNDQCKNFNDWFSNIKMNLQECFEPPETKMSMEQKLQKLSDFL
TLGGGKSKIQQVQTVLQHVKMLLPKAHVKELNSWLGSQELELENMESACQARARELNDSL
QQLLRYGD---------LDGNVLFGDMLSPLGP-DKLTMVFGNYREQFEIVARLNDSLKE
HGL-MEA----EETIKESTHLVDRYQGLLRQLHEIEEEDKLPPAEDQSFNGLAHDVTHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDAKIQMVVRQAE------HCEAPL
V--QETLTDLSNQWDHTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLRDLKK-QQEAG
LALQPGLPEKQAQLKICKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEIKQ
LHESLLQQLQDSVRKLESHVQEHSSYQICITDLNTTLDDISKEFVSLFDASKDQIMVEDK
M-QKLQELESGLRFQGGALKKASALAKSIKQNTSSAGQKI-IKDDIKSLKC-KQKDLEKR
IESVKRETENGLNSIL-ESKGSTEK----HAKF-PLPGGEMLATYDVPEPTQESAAAGKS
EGTWETNE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSSVEMILSKQLSLNIQESMQNTQDEWKVNELQNQPL
ELDIMLRNEQLKGMEELYAHLKERKAAIDLLEQSQHLSKTERRALALPTDRSPAYHMGSL
LQALLTWKKTKESQYGLLDSFQDQLIAAESSMNSFLAEAEGLKA-CSLDSAAYLGRIKKF
LGSVEKEKGSLSKLHAEWAHLSSLLSAEDQKLVEGQIKQLDRGWELVERLAHRKCFQQAT
EHSEFTYLQKKAQDIGVSL-H---QQQQCLLPRLNSPQQQEGSLDMVAPAAELQAIKYEL
SGLKRQAELQMKRLWGEREKETLEDALNSLNTQLEAL-EPLNREVE-----NRVKKCDLK
NRIKETLLWVKNMLAELNVPIALLPNDILSQIRRCKLIHDGILGKQQAVELLVEEVRGTT
PSLAACDNDGLNTLLEDLQNQYQVLLLKSTQRSQQLELKLEERSKLFAVIGNAKLALEKS
ESLMVPTQDKAS-TEAELERSRAVLKASQQQLREMESVISTHLQELTNAYKDANVFERLF
LDDQLKNLKTRTSRAQSCIQNNCNKVERKIKTHQEFHEQTAVLRKEVES--IQLSELLPL
HG----EIRQDAKEQLCHIKNKLAAVRGNISQVLTSEEVFDSLGLGWDGSLLE---QLQT
QVFERERELEEKIKQLDTFLIARDRYQALLSKIRGMDLQIKKRAKSLLKVPNKSP-KSTL
LSAQILIQKIEKAKGLRDEIMKKLSKSEAFDDSFKESEMLQLKLTAEEHARLQEDL-QNM
LLELQSKGVDEKAFHDKLENSLHVLKQIKSRLQKPLCVHLGIQHIQDEKETWEALGEQVQ
TEIFGIRAMRVAKEERE-ETAS-RTSGVEAKLQKLEGLQMELSKSIDLRTNILNDAYENA
THYDEIVTRAVGIITSLEAILLSYRVDLHHPKTSLELARCK-QEELQSAVTDIQNLTETL
GTISSPEAKEQLQGTLQELASKNSALKAVLEAQEAEDG--RCL------ENYRCYRKMRE
EICSRLRKMQTDLGQSMSPLPRSYKEALARLDQSKALTASLLSIKGDLVNLRQVLRCLRG
RCTESDGTRVLQVASALWERWLSLLEAARVWQQWSGELRREWKFISEEIEREAIILENLQ
EDFPEISKTKDTAPTEELCQLLDSLCQHEESVEKQQLLLALLLQRITSIQNIPEGTEAVE
T-TPALQEIRSMQERCNRLLQAAQNSKDEVQTEIEARHSLIKEITDVKHSFDQISTFSQN
LALEGQPGRAEQLQELQNSLQKGKLTFKNIMEKLRIKYSEMYSIVPSEIESQVEECREAL
EDADEKMSTEVSKSSPSCIMRRKIEEINNGLHGIEEMLQQKSKNIEEAQEIQKKIWDELD
LWHSKLNGLDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYSDLLKNTEAWIEKTSHLLANPACYDSSRTLSHRASTLQMA-LEDSEQKHSLLHSVFTD
LEDLSIIFETDDLIQ-SIQELSGQVAALQQQIVEALPHIQQVADDVVAIESEVKSMEKKV
AKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQTELRLPQTGTKPLPVFQRTNQLLQDVKLLENVTQEQNEL
LKV-IIKQTAECDGEIENLKQILNNYSAEFSPGHVSQKQVANLPSLQG-EMEGLEEQILN
LNQKKEDLLVGLKAAVLNLHEHLKREQQEGE--GDELSSGPS-EEGGAAERP--------
----TSSMSFLPVVKEEAEESSVKSEDGRKKTELPSAS--WSLLWKHSMDP-EEDGT-FS
SSATIVQE----ADGRISTCDSSMAHMFAPDSGSTE---QGPEPSPRLSQTGEGATPSIE
AAPLDFPHEQG-AFEATV--ERSRPQPSEVLHACKTQVAQLELWLQQASVAFEPETLDTD
MQQVVEQELAGCQAMLTDIEHKVASLLDTCKDQGLGDCGATQQEAEALSWKLKTVKCNLE
KVQMMLQEKYSEDQ--HPTALKQL--S--EPDLVLQPASLSELGSVITERPQFSKQKDVP
QTQ--VVELKPLEQKDLIKFTEFN-AKKTWLQYCQQDTDA-NQQSAS----------SSK
VPSPGNAAPDSGLPPQGQ-SGDKWQY-----L-HHELTSRPNSPAP-QLVEAQVVTNTST
LPSVSEYNFRCPTADELQTYTTQLEDLRQEANSLQTQESMTEETYTNLDKRLFELFLSLS
RCLGSVEELLQRPGLLREDASAQQALF----EKLALELKKLYLALGDKTDDLLKAVTWPG
KNTTLLPECFNALKVSLERTQAKAAWRSSSLKAGLDHSRSYQNEIKQLYSQLVKKKTALQ
QSLNEISGQSIDEQLQKADVHTVELQNSERQVAKLRNEGERLHFPHVLLQDVYKLEDVLD
SMWGILKAKYLELSSPFLSKSQQDALIQGMAELISIGKEKLATGPLQHAKSKVALQAQLQ
DHKGFFRKLVADVLLIQTYSAKMFPPSLQKGEIFGAEQVAEVKALEEDACLRGSQLQSLL
QKWQEFDDNYASLEKDLEVLTSSLPSLSLVEETEERLLERISFYQQIKRNIDGKHARLCQ
TLNEGKQLAASVSCPELEGQITKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYSR
DSDELTRWLESSQQTLNYWKEQSLNVSQDLDTIRNNIDSFFEFSKEVDEKSSLKSAVLST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRNAISEMISW
MNAMEPQVAGEDAELSQRSASQVKNLLQKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKIQHLEQLLESITENENKIQNLNSWLETQEE
KLKILQKPESAISMEKLLLDCQDIENQLAMKSKALDELRQSSLTLEG-GDMPLLEDMASG
IDELFQKKSNVTSQVYQLRASVQSVLQEWKAYDKLYDEANVMTIQLAYSMEHSKPVV--L
SMEALDCQVQNLQALQDEGESKEGSWEKLHEVVGRLKDSC-PSIAAIMEEKCQDVH--SR
WTRVNQ---DLADQLQEARGQLPLWKASHSAHTEATAWLQQQEAKFQQLANINMSGNNLA
DILPLALQDLK-ELQHDVLKTKEACLENSTLLDQLPP-PADPSTPGLHSGQLHSLQTAAY
LEKMLLAKSNEFEIVLAQFKDFGDRLAYLKDLI-MHEEENLNKLYHEEK--EEVPGSFLN
HVLALTAQSPDIERLNEESIRLPLSDITIKTLQNVNRQWIRATATAL-DHCRKLQGNGLN
-EN-FLLYCENWIQLLEKIEETLTMTVAHSLPALLEQQKTYEMLEAEVSVNQTVADAYVA
QSLQLLDTTETEKRPEFVSEVSKLSDQWQNAARGVQQRKCDIDRLVTQWQFFT-TSVE-D
LLRFLTDTGHLLSAAKEQDCYSLYQTRRLIHELKNKVIHVQRWRTTYELALEAGEKLRD-
-TPNPETKEFIDRQVSKLQDTWKDTELSLGEMISQLQNTA-ETWDHCEKKIKELKSGLQV
LNTQSRTPLPELHKDLHREKELTKEVEKSLANWTHNLKELQTMKADLSRRILAEDVTVLK
EQIELLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIDKLQ-----------------------------------------------KDCME
EISLFSENK-LQLKQMGDQLIKASSKAKAAEMEDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPSLEDEKEASETETDIED--PREIQADSWRKRREMEE----
SSCPQSLC----HLVPP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISESHP------
------------WHVPENPSHPKHHYKAMEGDGTVTPVPSDASTPYKPAYVKLLLHQGT-
DD---------GSKGSSQQ-ED-EQLDTLTG-QQ--PGAFDRWELIQAQELHGKLRIKGN
V---QQLNSDIGNITAWLEKTEA-ELEALRLAEPPSDIQEIALRVKRLQEILKAFDTYKT
LMVSVNVSHRESLPSESPESTE--LQNRLHQLSLSWDTVQGEMDSWRRDLRQSLMQCQDF
HQLSHNLLLWLASVESRRQKAL-V-TSPEADRQALLECQKELMQLGKELEDHQPQVSSLQ
EIASSLLIKGHGEDYIEAEEKVHVIGKKLKQLREQVAQDLMSFQGSLNPDP-SLDS----
--FD--EVD-SGL-PPPAASAP-----QFGA----ERSTKEEEAAD-------SRMSHLY
GPG-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASETVLPSGED-QA-SSGIDDLQI-----SLQXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX------IKLINIHVTDIIDGNPSIILGLIWTIILHFHIE----KLAQTLSCN
YNQ-----PSLDEESEV-G--SSPTASPPAKKSSK--AQARWQMSAKKALLLWAQQQCAT
-YES-VDVTDFKSSWRNGMAFLAVIHALRPDLIDLNSVKHRCNRDNLKDAFRIAERELKI
PKLLEPEDVDVNNPDEKSIMTYVAQFLKYSKDAPGTGQETQAKKSEDAA--------AWL
TFQEEKLQKAQKDSENESYCKKYER----LLSFLGSFNEEKQRFGDTPWRRQALAELSED
ELPLRQAWDSLSHQINTWKAKLNQALPSPLDEIEAWLQALEHAVDGDFQTVRDFSAARTQ
AQEKRTLFKNLMDKSDYHSNTLLAFENSDDEHLPLVPPSKLEEKQ-RQV-NNILGIKCIP
HLEMHYSTCPVLGLLDQVKSKWNVWDIKYGSKESVESLXXXXXRFV-EKEFLASFETSF-
KCEGW---SLD------LAGDGQNISKRHVMLDLNVCMYREHLYSLKSTLQKVLASWATY
VELLRFLKACFEETKKEQIKE-----VPFETLSQWNQQHTAFNEVGHFLIEVSNDEVGSS
ISRELRRLNKRWKKFITKTQLXXXXXX-X-XXXXXXXXXXXXX----------X-XXXXX
XXXXXXXXXXXXXXXXXXXXX--XXX----------------------------------
--------AGEEQSTAGEVSPEPLKLGEDVERLRRE------VGVWETETKSVLDLLGHP
DGVEAAAAAADSLQHLLAKGSLYEELVARAEDILQMDVQNILSQES---LQYVLSAGLQA
KVQE-MKEKIQINMIQLAAMLKNSSAASSPEMDVRLKLEESQRELESHITRAAQLLEPRE
STRGEISKYKEALMIFNSQSLAKYLKTVEELKSSVTEEGKLSLEERSREVCAKWESIHHE
LSLYIQQLKVDIEKGKLTETISKLEKQLNKEKKLIRRGRTKGLIKEHE--AFFSEEGHLH
QLDYHMQVLREICEE-LT--SQKSQHQVKRALTDYQQKIERLQKSASEIHRAL-----QA
-TG-GV--SRDKEGMNSSENGGGDAHSEAPFAKSDNPPPAEK---A-MEPMANVSPESEL
TSQHEACTVEEDEKGYSTPINSLLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-ALKKETDACWKEFEITSLRLESLVNDMKKP-VIAKARDRLKGQEQEFQM--
-----ALNDXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------XXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXAGSVHLMRDQARHLDHHLQELDISLKDAELGEASSCEKLTDFVSTR
-------GAQEELRGDNKLLEM-------CVFKNNELLKNLQDVQNQMSKIGLKDPTIPA
IKQRKKSLIRVDKDLDEYEDEKKHLQGMAASLPQFKDGREKALKQRCERTVLLWENTKAS
VAECLEQCERALELLKQYHNLKNILITLIQKEENVISLQASYLGKENLKKRIAEIEIVKE
EFNEHLEDVDKINQICKDLQFHLNKMSTFEEPPFEKEANSIVDRWLDINEKTEDCYENLG
RALALWEKLLTIRNVIDEWIEKALQKVKL-PLTEEERKRLKEXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXLKKSEYVKTGVAGESGGWAFSGNPDGLREDLDQAKTQIG
MTESLLHALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSTLLNDQCKNFDDWFNNMNMNLKECFDSPETKENLEYKLQKLSEFL
TLEGRESKVQQVETALNQVKKHLLKGHVKELXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQFESLAQLNNSLKE
YGLGEE-----EEIIAESTLLIERYQTLSRRLDEHDGAEKLSPVEDQRFHDLAQEVIHWI
TECKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKLQNIRKQAE------SSKAPM
A--QQTLTDIRHQWDNTLRLANTYLSHQEKLLLEGEKYLQSKEALRLMLTELKT-KQEAG
FVLQNGLQEKKAQLKNYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLHATLDQFAEELASFSTETMDQIAVEGK
L-QKLQDLEARLSLHNGALEKISTLSESIKQNSSWVGQKL-IEDAVSSLKG-KQAALEKS
LGSAQQETEKWLSSIP-NSTCTPDG----QEQL-ALLDREEPVPSGVRAPTPDAAAGETP
GAAW--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EVNK--NSDVEMVLSKQLPLHVQESMKNTEDEQKVNELQNQPL
ELDLMLRTEQLEEIEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-GALDIATYLDKVQKI
LASIEKEKDSLGKLKIQWENISDFLTGMDKKLLRSQIHQLEHGWEHVEQLVQKKYSQQVV
EYDEFNFFMSAIQDLAHSL-R---QQHRCLQLRLTAPEQREVDQTVAPLATELQAIKHRF
STLKGRADLQMKRIWGEKEKKTLENGIHNLQKQLDAL-EPLNLEVE-----NQIKKCELG
NKLEEVVLWVKNLLGECMHTIPLLPDDILSQIRRCKLTHDGILEKQQLXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XTLMGPMMEPTP-TEAELEHQRVALKIAQEELQEAESIISTYFQELANFCKELNVFERLF
LGDQLKNLKTRANRTQRFMQTKSKEVDHKLNFYGELREKTSALQKEVDD--MQHNELL-L
NE----EIHLDVKEALYNLKDRHAVTHSSLSQVLKLKEMLECIGLNWDFSQLD---QLQT
QVFRKEKELEESMKQLDSFGTEQSNYQASLSKMRALDSEIKQRAKAVLTSFSASP-EESL
RTAHVLNQKIEKAKNLYHEMLGKLSENTAFDESFREKEALQINLYVEENSKLQKAL-QNL
ILTSQPQEMNEKDFQDKLDNSLDVFNQLKSQLEQPLLINLEMQHIQKEKENCEVLQEQIQ
AEVFSIKAVTVIAEQREKESAS-EAGPGETRLRDLEALQTELHTSLVWRTDVLDDAFKNM
THYNAAVTKAAEIVTALETIVAFHKVDLDNPDASLTMPHWK-EEEFEATMADMRDLSEKL
GAVCSPEAKLQLQQTLQELISKDSAVREAANEGKAEME--RCL------EDYERYRNTKE
KICTDLGKMETSLGQSMSQLPLSYKEALERSEQSKALVTNLLSTKEELMKLRQVLRHLRG
RCSEKDGVCLLGSVSALWERWLRLLEAARTWEMWCGVRQRDWKFVSEEIEREAIILDDLH
EDLPEISKTNEAASTEELCALRDSFCRYEEDVEKQQLVLALLFQSVRSIQNVPEDVRAVE
T-VPAFQEIASMQEQCIKLLTQAQKNKDLVQAEIQERDSFKKEIMVLKEGLQQRLASLQR
VESQGRPE-TEALEELQSSLKKGQLAFEEMMEKSRIKYSELYTIVPAEIESQMEECRKTL
KALDEKISSEVSKSSPSYAMTRKIEEINNGLHNVEKMLQQKSKSIEKAQEMQKKMWDELD
LWHAKLNELDSEVQDTVEQDPGQAQEWMDNLMIPLQQYQQVAQRAESRTSQLNKXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXX----------------------------------
-VILENLRPMKKTIAEIVSYQAELSLPQRGLKPLPVFQRTAQLVQDVRLLENVAQEQTEL
LKI-ATEQIDECDGEIEQLKETLNNYSAEFSPERVSPDRVANLPQVQG-EINSLEEQILS
LNQKKEELLVNLKTAVLSLHQHLKQEQHESE--KETLSASAP-EEGGVAKR-EASDWKL-
--DRAGSMSLLPAVAEEAEEGSVKSEXXXXXXXXXXXX--XXXXXXXXXXX-XXXXX-XX
XXXXXXXM----ADRRMSTCDGSVAQGLAPDSLN-------------PHQTKEGATPPIQ
AASLDFPEEHK-ASEATV--EQARPEPAEVLHVCQTQVAELEQWLAQ---AFEPETLNPG
MQQVVEQQLVGCQAMLTEIEHKVVSLLENCKDQGLGDGGAIQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--QSTIGKKA--S--EHEKVLQPDNLSAFDSMIGERPLFSRHKDVQ
RPQ--VPELKPVEQKEFIKFIELNVAKKTGPQYSQRAQDP-TQESSL---------SS-E
ASSSQDDAPNVVLSAQGQ-RGDKWQY-----L-QHELSSKICLPFP-QLVEPQVSPNISI
LPSVGMYSFGYPTTEELQAYTTQLEDLRQEANTLQAQENLTEETYVNMDKKVFDLLLTLS
QCLRSVEEMLQTPALFRGDLYAQQVHY----EALALELKKLYLAMSDKKGELSKAVTCPG
QNPSLFLECFNQLQECLEHIQATAAARSKSLRAGLDYHRSYQGETKRLYDQLIKNKTSLQ
QSLNEISGQSVDKQLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLD
DMWAILRGRYSELSNPSITEISQDALWQGLVELVAIGKEKLAHGHLQQTKSQAALRAHLQ
NHKDFFQKLVADMVFIQTYSNKRFPSLLQKKEKFGTEQVKEVKLLEEKSQEYGMKLQSLL
QKWEDFDENYASLEKELEILVSTLPSVSLVEETEERLTERISFYQQIKRNIDEKHARLYQ
TLTEGRQLMAAVSCPELEGQISKLEEQWLSLNKKIDNELHRLQTLLKHLVXX----XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXEFSKEVDGKSSLKSAVVST
GNQLLHLKEADAAALRASLAQFDQKWAMLITQLPDIQEKLHQLQMEKLPSRPAITETIHW
MNGVEHQIPGEESEHSPSSASQVKNLLHMYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRLHGLLNRKIQHFEQLLESISENENKIQMLNNWMEAQEE
RLKTLQRPGGVVSVQKTLLDCQDIENQLAMKSKSLDELRESHLTLES-GSVPLLEDTASA
IDGLFQKRTSVINQVHQLKASMQSVLQEWKMYEELYDEVTLLTIRFWYCMEHSKPVV--V
SLEALRCQVQNLQALQDEAENSEGSWEKLQGVIGKLKNHC-PSTAEIIEEKYQNTH--TX
XXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX-ELQRDVQNTAEALLQHAPLLERLRQLSAEPCPPALLSGRTHALQRAAY
LEKMLLVKANEFEFLLSQFKDFENRLESLQGLI-MQEEENLDKLYQKAK--EGNPDAILV
HVLSLTAQSPDIERLNEVSLKLPLSDMAVKTLQNVNRQWIRATATAL-ERCSDLQGVXXX
-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMLEAEVSVNQTIADSLVT
QTLQLLDTAEVEERSDFVLKFATLKDQWHSAAQRVQQRKGDINGQVRQWHNFN-ASVE-D
LLRFLTDTSHLLSAATSLDCCSLSQTRRLIQELKSKEIGFQRRQTTYELTLEAGEKLLS-
-MTNLDAKESVKEKIQQLQGNWKDTELQVGEMIKHFQAFV-ETWDRCEKKIKELKSRLQV
LKAKSKEPLPELHEVLHKEKELLKELEKSLAAWALNLEKFSPMKTELAGRILWEDLVLLE
ELTPHLHRQWEDLCCRVAVRKQEIEDRLNSWAVFTDKNKDLCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KXXXX
XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------
---------------------------------------VKKLKETFAFIQQLDKSMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXD
SAERLAAYPNSSEVLYTIAKEELKRCEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQKRVAAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEEVHRY
CQEVFGRVSRFHRRLT ARAPGLEDEKEASENETDLED--PREIPGDAWCKRGESEG----
PSSPQSLC----QLMPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGQSLSESHS------
------------WHVPDSPSCHTRPYKPREGDRNVPPIPSDASTPYKPDYAKLLLSSGT-
TGGKED---PRGVSCSPQQ-ED-AGQAG----QQ--SGAFERWELIQPQELHHKRRMK QN
L---QQLNSDINTITAWLRNTEA-ELETLKTAPPAPRLEELELRVKRLKEIVKAFGTSKA
LMSSVNSSSKEFLLAESTEPKD--LQNRLHQLSLHWEAAQGAVDHWREGLR QSL MQCQDF
RELSQSLLLWLESTENRRQEAC-V-TDPGADPQALRESQEALTQLEQELRGRQPQVNSLQ
ELSSSLLSTGHGEDYVEADEKVHVIGKKFQQLLEKVSQDLMSLQGSQNPDP-SLPS----
--ID--RVDSRGQ-HPATASATQAKP---GA----ESTAEGKAQED-------NRVPG--
-AG-SSRPQRSFLSRVIRVALPLQLLLLLLLLLACLLPTSEEDYSCAQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MVHEGNQRWDNLQKRVTAVLRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSRTPGLEDEKEASENETDMED--PRELQTDSWRKRGESEE----
PPSPQALC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAL-----------------------SGKSISDGHS------
------------WHVTDSPSCPKHNYKQMESDRNVPPIPSDSSTPYKPAYVKLLLHPGP-
D-GKEG---PDASNVSPQQ-GD-EQLATLTG-QQ--SGAFDRWELIQAQELHSKLRMKQN
V---QQLNSDISDITGWLEKTEA-ELETLKTAAPPSNVQELALQAKRLREILQAFDAYKA
LMVSVSMGSKESLPTEGAESSE--LQSRLRQLSLRWEAVQGVVDSWKGDL RQSLMQ CQDF
HRCCQDLLLWLAGAENRRRKAH-V-AHPEADRQALLKCQRELMQLEKELVDHQPQVTSLK
EISSSLLVKGHGEDYIEAEEKVHVIEKKLKQLREQVAQDLRAL QGSQVSPL---EA----
--FL--GRE---------------------------VTVVA----N-------RKTESHT
GSS-QPRPRRS FLSRVFRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVPPAEDE-QV-PLAIHDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSAVSDLFTDIKKGHILLDLLEVLSGQQLPRDKGLNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVDGNPSIILGLIWTIILHFHIE----ELARTLSCD
YNP-----PPADDVNVP-D--ASPTSSPPAKKCSK--AQERWQMSAKKALLLWAQEQCAT
XXXX-XXXXGFKSSWRTAFCIHA------RDLVDMTSVKHRSNKDNLTEAFRIAEQELKI
PRLLEPEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX--------XXX
XXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXISLWKTELNRALPSPLQQTEAWLQTLEELVDGDLPASQDCAEAIAL
TQEKMTLFKSLMDEWDHNLNTLTAFENRDEKHLPLVPPDKLEEMK-RRI-NNIAGRNFAA
LLEFHYHRCSVLGLLHEVRSRLEVWNARYGNEASVELLQEDWHKFIEEKGLLVQIDTSFQ
KCEEI---YKD------LAGECQYINEQYKTMENNVCMYKKHIYNVKSTLQKVLACWATY
MEKLRSLKACFEETKKEQIKE-----VPFEVLSQWNVEHITLNEVGNFLIGVSNDEVGSS
ISKELRRLNKRWRKFITKTQLEMKLPL-V-KKQDQPILDNSGN----------I-LLPKE
EKPTVDVLADMSSQVPEDHRE--DLK----------------------------------
--------AGEEHEEK-EEFMGQLNVTREVENLTRQ------VDIWEAETKSVLDLLRQQ
DDVG--MPMEESLQHLHIKGPMYDELVFKNENTLQKDVQNISNQES---LQHVLTDGLQR
KILE-AKEKIQINVVKLIAASKNSSDI-SPGLDVRLQVQESQKELESQITKAEQLLEQRE
SPTALISKYKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLHRE
LSLYMQQLKVDIEKEKLSDCIFKLEKQINREKKLLRRGRTKGLLQEHE--ACFSKEGILQ
QLHQHRDVLRELCEE-LT--LQESQQEVKRTLRDYEQKIDRLLRCASEIHMTL-----RD
PSG-NK------ESIATTENGGRDSHSEVPFAKSDNEPSNEK---A-IEPV-NVILASEM
KPQQGESI----MEKHDKDIQSLQNRCIAQKEILESHLQSNKFRILSXXXXXXXXXXXXX
XXXXXXXX-GLKNETDDHWKEFEITSFKLENRVSDAEKP-LIVKARDELQEQERELQMAL
HARLASLETALRLVSPIEKESVSLCGLD-LSLHELVIQESCVLNADGIHQNLRD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIELCNE---ELDTFASKGLH
PSDLHATQNIVLSCRTQLEEMSHKVQAREEALRAVEDFLASLRAAGLSAEGV-ADWLALN
LQEAPGNTSLGKNEGRAMDPLKDKAKHLDERLETLGIRFKDIEQGENTSCEKLVDALSIK
VLERHGCSPREELTEEAELLMA-------CASKNNELFKNIQEVQNQISKVGLKDPTVPA
VKHRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXLDQCGRVLELLKQYHNFKSILTALIQKEENAISLQASYMGKENLKKRIAEXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXINEKTEDHYENLG
RALALWDKLYNLKNVVDEWTEEVLQKMELQQLTEEARERLKEELQVHEQKS-WECSRRAE
IQSLLQSSEKPLELQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQFESMAQLNSSLKE
FGL-TEE----EAITMESTRLLDRYQGLLRQVRDIEEEDKLPRTEDPSFNDLARDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXX------XXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXHQEMLLLEGEKYLKSKEDLRLMLTDLKK-NQEAG
FALQHGLQEKNAQLNIYKKFLKKAQDLTSLLKELESQGNYLLECTNNPSFSKEPWLEIKL
LHRSLLQQLQDSVQKLEGHVQEHHSYQVCITDMNATLDSLCKEFSSFAEKPEAQIAAEEK
L-QKLEELENQLHLQDDTLDKISALAKSVKQNTSSVGQKM-IQDDVEALQR-KQKDLGSR
IESAKEETESCLNNML-RWKHSTEE----EEKF-PLPGGE-QVTCEVLEAAQEAAAVEKW
EEDQ--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EMNQ--NSAVETILSKQLSVDVQGSMKNNEDEQKVNELRDQPL
ELDMMLRNEQLKEIEELLTQLEAKKAALEALEPSTHLNQAENSVMSLRDTRYPAQHLDRL
RQALVTLKEDKESQYCLLRDFQEQLTAAQCSRKAMLTEKESVKG-GSLDAATYLDKMKEL
LASIEREKGFLSKLKIEWEDVSKLLTDMDKKLLESQMQQLARGWERAEQLVQRKQSQQAV
QSAEFTSIMSQVRDLERSL-Q---RQQQCLQSWLRSSDSQEGNPSVVALATKLHTTKHRF
SVLKGLAELQMKRIWGEKENMILEEAINNLKNQWEAL-APLNLEVE-----NQIKKCDIG
SEVKEATQWVGNVLGELTSPVSLLPEDIVSQIRKCKVTHDNILDKQQTLESLVGKIKDGI
SNLPSDESNDLNELLVDLQNQYQALVLKSTQRSQQLERQLEDRSKLFGMIGQVYCTLQKN
ELLMMDRAGMTS-TGAELEQHLVTLRGSQEELQEAANLISTLLQELSNISEGLSVFERLF
LDDHLTNLQTRVDQTQRFIENTCREVEHKLNFVRAFQEKVSVLQKEVDS--IQHSKLL-L
NQ----AIDQDTKKELHGLKDRLMSVQRCILQVLKLKEVFDCMGLTWDHPQLD---QLQV
QILEKETRLEEQIKQLDVLVAEHNRCQEALSKMKSVDWHIKKRAEALGNAADTSP-ETYL
LDAQILNQRIEKAKCFHDEMIRKLSESEAFEDAFKEKEIEQIMQNAEDNEKLHRLL-QNT
IVESQPKEIDEKTLQDTLENSLRTLNQIKSQLQQPLVIDPDITHIQNEKDNCEAWQERVQ
A-------------------------------------------GVHILKNLLNEAYENV
TCYNEAVTRAAGLIASLGTIQASQTADLDNPEESLAMLRHK-QEELEYTLADIQGLTARL
GAVCSPQANLQVQGTLQDLVSKKSALQEAAREAEAKLE--RYL------QNYKNYGKIKE
KICAHLGKMRTVLGQSIFPLPVSYKAALERLEQSKVLLTSVESVKEDLVKLRQVIRHLSP
RCTGRVGVLAQWALSALWEEWLRLLEAARAWETWSESLKQSWKFVSQEIEREAIILDNLQ
EELPEVSRTREAASQEELSELSESLCRYKQQVEKQQLLLSLLLERLKSVQTVPESPRALG
T-FPALQEITAMQERCNTLFQKAQKSQELVQTEIQDRHSFTKEIIALKRLFQQTAASFQN
LSAQEHPDEAGRLEELQSILKEGRQTLERLMEKLRIKYSEMYTIVPAEMSSQVEECQKAL
EDLDEKISNEVRKSSPSYAMHRKIEEINSGLQHVEKMLQQKSKDIEEAQEIQKKMWDELD
LWHARLNELDAEVQDIVEQDPGQAQEWMDHLMTPLQLYQQVSQGAEWRTSQLNKATVKME
EYSELVKSTEAWIGNISRLLANPANYDSARTLSHHASTLQMA-LEDSEQKLSLLHSIFTD
LEDFSAIFDTDELTQ-SIQELSGQVTALQQKLMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENLRPMKKTIAEIMSYQVELRLPQAEMKPLPVFLRTSQLLQDVKLLENMTQEQNEL
LKV-VLNQTNEYDEEIKNFKEILYNYSDDDSPEH----QAGYLPHCQG-EIEQVEKQILS
LNQKKEELLVDLKAAVLNLQEHLKQEQEEIG--GELLPARVS-EEGGMAER-DAPDWQL-
--NRRGSMSFLPVVKEEAEEGSVKSEDGDKKTEPSSAS--WSSVWKHDSDE-EEDRA-SS
SSATLIQE----ADGKISTCDSSMVQSLAPASPNTE---QGTEFSPGPSQTEEGATPPIE
ALDFPDEPGA---AGATV--GKGGPEPAQLLHACKSRVAELELWLQQASVAFEPETLNAD
MQQVVEQQLVGCQAMLIDIEHKVASLLETCKEQGLGESGAIQYEAEALSLKLSTVRCDLE
KVQAVLQQRCSEDQ--HLAILKKP--P--EHQNALQPGDLSELEPLVIERPQFSRQKDVQ
PQQ--VLELKTLDQKNLIKFTEVN-AKKMGPQCCQRDKDTASQESSE---------SN-R
DSHPESGVPD--LSPEGQ-VGDKWLY-----L-HRELSAQSRPPLP-QLVEPQVAATMNI
LPSVSVYNFRYPTAEELKTYTTQLEDLHQEASHLQTQEHMTDDNYINLEKKLFDLFLALS
QCLGSVEELLHTPGLFREDLAAQQAHH----EALALELKNLHLALNGKKDNLVKAMTFPG
RSPSLLPECFQHLQARLELMQVTASSKSQSLKAGLDYNRSYQNEIKRLYDQLIQKKAALQ
QSLNEIGGQCVGEQLQKADAHMAELQNSESQVAKLRDQGERLHLPYAVLQEVFKLEDVLD
GMWALLRHRCSDLSGPLIAESQHEALLQGMAELVRIGKEKLSADHLRPAKSKAALQAQVL
HHKVFFQKLLADMLFIQTYCAKVSPSLVQNRETFWAEQVTQVKILQQESCQRGTLLQSLL
QKWEEFDANYACLEKDLESLLSTLPSVSLVEETEERLVERISLYQQIKRNLDGKHARLYQ
TLSEGKQLVGAVSCAELGVQMAKLEEQWLSLDKKIDQELHRLQTLLKHLL------SYNR
DSDELTRWLGSAQQTLNHWKERSLDVSQDLETVRSNISSFFEFAKEVDEKSSLKTAVLST
GNQLLHLKEADTATLRACLAQFEQKWTLLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MDTVQRAD--EGAELCPSSTSQVRSLLQKHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIQHLEQLLEGITESENKIQLLNSWLEAQEE
RLHALQRLEGVASLERLLLDCQDIENQLEMKSKALDELRQSSLTLES-GTTPLLEDMVSK
IDELLRRRDSVINQIHQLKNSMESVLQEWRTCGKLYEEANVMTIRFWYCLEHSQPAV--L
SPEALRCQVQNLQXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX--XX
WTQVNQ---EVAEQLQKAQSMLQLWKTYRSAHSEATAKLEQQEVKFQQLANINMSASNQA
ETLPWALQNIK-ELRHNVQKTREEFFKISTPLDRLPQ-PAESSTHAFLSGQPHILQRAAY
LEKMLLRRASDFEFVLSQFKDFEDQLGSLKALI-EQEEENLNKLDSQEK--EDTPALLLK
HVLALTAHSPDIERLNDLSLKLPLSEVDVKTLQKVNRHWIRATATAL-DRYSELQGIALN
-EN-FVYCCEKWVQLLEKVEEKLGASVGDSLPALLEQQKALEMLEAEVSVHQAVADTYIT
QALQLLDTEEVKRRPEFVSEFSELVDRWQRAAQGVRERKREVEGLLRQWQYFT-ASAE-G
LLRFLADTGHLLSALEGQDCYSLCQARSLIQELKNKEIHFQRWKTTYALTLEAGDKLKN-
-ISNLETKESVDRSLSRLQTSWEDAALRLGEAGKQLQGMV-QTWEQCAKKMQELKSRLQV
CKAQSSSPLPELHEDLQKERERVKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-----------------------------------------------XDCME
EINLFSENK-LRLKQMGDQLIKASNKTRAVEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETLAFIQQLDRNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFSDDYSRFEDWLQ
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQRRVTAVLRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKIRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSDPLDAVLIEDELEELHRY
CQEVFGRVSRFHQRLTSHAPGLEDEKEASETETDLED--PREIPTNSWHKRGENEE----
PSPPQSLC----HLVPLAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EEE----EEGPFYSALSDVEIPENPEAYLKMTTKTLQASSXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKPLLRPGADGGKEVATVLNGSPQQED-
TRM---------------------------------SXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXEIIKAFDTYKA
LLGSAHASSKDCLSGESAEAVE--LRSRLQQLSVRWEEAQGAVDSWRAGLRQSLMQCQDF
HQLSHRLLLWLASAEHRRQRAH-V-ADPEADPQALLECQKELKXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXVHVIEKKLKQLLEQVAQDLMSLQGNPNPDA-PLPA----
--SD--KAS-QRP-SAAAGPAPQVKV-GVEG----TARSRRQA---------------ES
SPS-SSRPQRSFVSRVLRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----------------------------------MED--SREIQSDSWRKRGESEE----
PSSPQSLC----HLVPPAP----AHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPFYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQMEGDRNVPPIPSDSSTPYKPAFVKLLLPSGT-
DGGKEG---ARIVNGSPQQ-ED----KGLTG-QQ--SGAFDRWEQIQAQGLHNKLEIKQD
L---QQLNSDVCDITTWLEETEA-ELEMLKMAKPPSNMQEMELRVKRLKEILKAFDTYKA
SVVSVNVSGKEFLQAESTESKE--LQNRLHQLSLHWDAAQDTVDSWREG LWQSLM QCQEF
HQLSQSLLLWLASAENRRQKAH-V-ADPEAEPKVLLECQKELMQLEKELVERQPQVNSLQ
EISSSLLMKGHREDYIEAEEKVHVIGKKLKQLLEQVSQDLKSL QRSQNPDP-SLSR----
--FD--EVD-FGD-QQPAAASVPPPQAKSGA----ERTAKAKSKTD-------SRVPGPT
GPG-SSRPQ RSFLSRVFRAALPLQLLLLLLLFLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QG-SWGIDNLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILH FHIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPASSPPAKKCSK--VQARWQMSA KKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKNVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAM--------VWL
TLQKERLQKLLKDSENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKQDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEV---YKN------LAGECQNISKQYMMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENY-Q--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DDVD--TSVEESLKHLIAKGSMYDELMARSEDMLQMDIQNISSRES---FQHVLATGLQA
KIQE-AKEKVQINVVKLIAALKNLTDV-SPELDIRLKMEESQKELESYMMRAQQLLGQRE
SPGGLISKYKEALIISNTKSLAKYLKAVEDLKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKEKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TAG-GT--SKNEGTITTSENRGGDPHNEAPFAKSDNQPSTEK---A-MEPTMKFSLASEL
KPPQEESIM---EKDYSASINSLLERYDTYRDILEHYLQNNEFRITSGFSSEEDRSSSCL
QAKLTDLQ-VIKNETDAYWKEFEIISLKLENHVNDIKRP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADRIYQQLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNHL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTPKFSAEPI-TDLSASD
TQVTQENTLTIKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAEWGEDTSCENLLDAFSIK
LSETHGYGVQEEFTEENKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDDREKTVNQQCQNTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANITVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDREKLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGDSNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIQMNLKECFESSETKKSVEQKLQKLSDFL
SLEGRNSKIKQVDSVLKHVKKHLPKAHVKELTSWLVGQEFELEKMESICQARAKELEDSL
EQLLRLRDDHRNLSKWLTNQEEKWKGMEESGEKTELFCQALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMESTCLMGRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
I--QKTLADISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCITDLNTTLDNFSKEFVSFSDKAVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENS
LESAKQEMECCLNSIL-KSKCSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDSL
LQALITLKKNKESQCCLLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVMYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHDWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEEQAGNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDIR
NKMKNTILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGGDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQKS
ETLIIPRVETTA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRFIQNKCNEVEHKIKFCRQFHEKTSALQEEVDN--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---RLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAVDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKAFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVW
AEMCSIKAVNAIEKQR--EENSSEVSDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRK-QEELESTVAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKAQETEAE--RYL------ENYKCYRKIEE
DIYSNLSKMETVLGQSMSSLPLSYREALESLEQSKALVSNLLSTKEELMKLRHILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLFQRIRSIQNVPESSGAVK
T-VSAFQEITSMQERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQQMADDVVAIESEVKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEILSYQVELRLPQTGMKPLPVFQRANQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-EVERMEKQILS
LNQRKEDLLVDLKATVLNLHQHLKQEQEEVE--RDRLPAVTS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSMKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNHTEEGTTPRIE
AATLDSSDAQG-GLETRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHQEALQPVNLSELESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-TQESSA----------SNQ
ASSPENDVPDLILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEP--------
------------------------------------QENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWSG
KNTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAYTVELENAENRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSSPFISESQQDALLQGVVELVKIGKEKLAHGHLKQTKSKVALQAQIE
NHQVFFQKLVADMLLIQAYSAKILPSLLQKRETFWAEQVTEVKILEEKSRQCGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKRLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKILQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GAVPLLEDTASR
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNIH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA
EILPPAVQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PEESSTHMLLPSPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-MHEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDMANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQRVRQRKGDVDGLVRQWQDFT-TSVE-N
LFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDTESQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNKKELIKELEQSLASWTQNLKELQTMKADLTRHILMEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDEKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--AREIQTNSWRKRAESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GGLAGITE-QQ--SGAFDRWELIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIEVRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAARSAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKVDPQALLECRRELMQLEEELVERQPQVDMLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLQEQVSQDLMALQGTQNPAP-PLPS----
--FD--EVD-SGD-QPPATSVPAPQAKFRAV----RTA--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QG-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPASSPPAKKCSK--VQARWQM SARKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPGLIDMKSVKHRSNKDNLREAFRIAEQELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQG-KVKDAM--------GWL
TLQKEKLQKLLKDSENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSVKRDPDELDKD
HLQLREAWDGLNHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENYNQ--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DDVD--TSMEESLKHLIAKGSMYDELMARSEDMLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLIAALKNLTDV-SPELDIRLKMEESQKELESYMMRAQQLLGQRE
SPGELISKYKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--TCFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TAG-GT--SKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK---A-MEPTKKFSLASEL
RPLQEESIM---EKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENHVNDIKKP-FVIKERDTLKERERELQMTL
NTRMESLETALRLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADHIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAELSAEPV-TDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK
LSETHGCGVQEEFTEENKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWLTNQEEKWKGMEESGEKTELFCQALARKREQFESAAQLNNSLKE
YGF-TEE----EEIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLQC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLNAQESMKNTEDERKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGGDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAMIRKFQLMVQES
ETLIIPRVETAA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEVDS--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRR
LNAQILSQRIEKAKCLCDEIIKKLNENKAFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVW
AEMCSIKAVTAIEKQR--EENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENV
TRYKEAVTRAVESITSLEAILIPYRVDVGNPEESLEMPLRK-QEELESTVAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKAQETEAE--RYL------ENYKCYRKIEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQATTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQRMADDMVAIESEVKSMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENMTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-EIERMEKQILS
LNQRKEDLLVDLKATVLNLHQHLKQEQEGVE--RDRLPAVTS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTSDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
ADTLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAVEPETLNSD
MQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILRKS--SEPEHQEALQPVNLSELESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-TQESSA----------SNQ
ATSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQHEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSGPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKMLEEKSRQCGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVISI
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSMHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSRALDELKQSYLTLES-GAVPLLEDTASQ
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHGEAAARVKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI-MQEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT-TSVE-N
LFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTYALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GGLAGITE-QQ--SGAFDRWEMIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPRALLECRRELMQLEKELVERQPQVDMLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAP-PLPS----
--FD--EVD-SGD-QPPATSVPAPRAKFRAV----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELVDEDLSASQDHSQAMTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPKKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDSSGN----------I-L-SKE
EKATVEFSTDTSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
RPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LL--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATMKFNLASEL
KPPQTGSIT---EKDYSASVNSLLERYDTYRDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKKETDVCWKEFEIISLKLENHVSDIKKP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLGALSVK
LPETHGCGVQEEFAEENRLLEA-------CIFKNNELRKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKILDEYEEEKRHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENAKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELENMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKP------EEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEVIMSKQLSLNAQESMKNTDDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETRALVLHNTGYSAQPLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVV
EYDEFTALMNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHQIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRE-EEKSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAHENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESLEMPLRK-QEELESTIAHIQDLTGKL
GMISSPEAKLQLQCTLQELVSKNSAMKETFKARKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
S-VPAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLADLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EESGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEENSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPEPSLRPSQTEEGTTPPIE
AATLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSALESIVTERPLFSRQKDFQ
QQ--QVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDA-AQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGLQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHHVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILSPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEAALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFHFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAEMIKQFQSTG-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLMKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKMKQN
L---QQLNSDISAITTWLQKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRAKFRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAAVPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASGPMPPTKDE-QL-SSGIDDLHF-----SLQ---------AEQEYTQKKTF
TCWINSQLAKHNPPSVITDLFTDIKKGQVLLDLLEVLSGQQLAREKGSNTFQCRSNIEHA
LTFLKKQS------IKLINIHVTDIAEGNPSIILGLIWTIILH FHVSTLIEEVAWTLSCN
YNQ-----PSLDCVSVV-D--LSPASGPPPKKRSK--AQARWKMSAKKALLLWAQEQCAM
-H GS-VNVTDFKSSWRNGMAFLAVIHAVRPDLIDMDSVKDRSSKDNLKEAFRIAELELNI
PRLLDPEDVDVINPDEKSIMTYVAQFLQYSKDLPVAGDEVRV-VVKDAT--------VWL
ISQEEKLHKLQMESEKETYFKKS---------QVSSFNEEKKAFLDVLSLKRNVVGLVDD
QSRLRQAWDKLTNQINEWTAKLDQILPPPLDQIEVWLQEIEHLIAEDLPDSQNYNQTMAL
IKERISSFKSLMDEFDRHLSSLLKFENKDEQHMPMVPPDKLEEMR-RRLFHNIMGTNFIG
LLEFHYYLCSVLGLIEEVKSKLNLWNIKYGTRESVELLLGDWHKFIEEKEFLIQLESSFK
TCETM---IKN------LAGDPQNISKQFKMVESQISMCKKCMYNIKTTLQKVLSSWTTY
TENLHSLKTWLEESRKEHPKQ-----VPFETLASWNSVLTTINEVGKFLIDVSNQQVGSS
INKELKRLNKRWAKFIKKTQFEMKLLF-T-QEQEQSGLDGTAN----------NKLSLEK
NSASYNGSTDISAEALRKHIQ--HLE----------------------------------
--------TGKENEAVIKESTEILQMLEEMEEFIDQ------VATWETEIRPVLDFIKQQ
GYVE--ATMEESLQNLIARGSKYQELVTRKENALEIIAKNILSQVQ---LQHFHTSGLQT
QIKE-AKDKVQNNMAELDAVLQASYET-SLEIDVRAKFEKSQKELESDITKAQQLLRSKG
NPGNLVSQKKDILAILNSKNLDKFLKTAEQLKNIVPPDEKLSLEQISRELSKEWEVLHQE
ICLYIYRIKIEIEK-RLTENISKLEKQLNKEKKLLSKGKTKGLIEEHE--ACFFDEGSLC
QLDLHMEALRELSEE-LT--SEESRQEIRKTIIDYGQRQNEIKNAASEIYMML-----KA
VNE-NTQMPRKKKPLSTSENGGRDAGKMVQPSEPNDATSEEA---S-GSVNFDLEYFSIL
KHHKEE----RGTEDGNVPFKNLLERYDAQRDNLELQLQSNKVRVLSEFPSEKERSISCL
KDKLTDLQ-VLKNETDSCWTEFEITSSNLEKIVKDPERS-TLSQTREKLKRKEEELQVIL
SKRMKSLEAALRIVLPVEKEAFLLVDSE-QFLHKINIQEFNLAGVDDVYQNLKD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------RCIVKQIELCNNL-EPSGSSALNEFN
WIDLDAIQSIIVKYRAQFEEMNIKMQNSEMAIKALEDFLALLRKVKLSLQST-TDFSTSD
IPEMQENSWTIEDVQKKISLMKEEAKCLDQRMKMLDISLKDAEQGEDTCCEKLVEVFSKM
IDETHGHNEHEDFTEQVQLQEV-------FVAKNTDVLKNIKYIQDQINKIGLKDPTIPA
VKQRIKSLTKLEKDLDYYAEEINYLKKMASSLPELKDGKGETPSQQCQETTCLWEDVKSS
LEECLEQCQRAMDLLKQYHNCKSILTSLIHKEESVISLQASYMGKENLKRRIAKIEVVRE
EFNEHSEDVEKINQICKNLQFQLNKMITFEEPPFEKEANVIVDRWLDINEKTENYYDNLV
RALALWDKLLNLTSIIDEWIEKVLRKVEVHKLNDAERTQVQEELKIQEQNSAKFGARLVE
IEEFLQISEPPLELQVIKSSLLNRIEQIKMHLMDKSTLSEVNGSTAELKEDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHNMILLENQIGCLTPELSELKKQYESIN
DLFSTKKRTLQDHFSNLLNDQCKKFDDWFSNIQLTLKECFESPETKKCMEEKLQKLNDSL
TFEGKTKDIQEVQTALNNVKRHLPKASVKRLSNWIVARELELQKMKFSCQMQAKQLHDCL
QQLLRLQEDYINLSKWLMNQEEKWKEIGVE-KEPDFFCQALTRKRQLFESLAELNNSLKK
FGL-TR-----EEIVIESTNLIEKYETFLTQVCEKGN-HQSPAAVDQSFEDLVHDVFSWI
MGIKESLMVLNSTEGKMPLEERIQKIKEIILLKPEGDMKIQNIMSLGE------TGKASL
V--QDTLSDIKNQWDHTIHLANTYLSHQEKIQLEGEKYLQSKDDLRLMLTELKK-KQESG
FALQNGLQGKKAQLKIYKKFLQKAEDLTSLLNELKTQGNYLLECTKNPKFSEEKWLEIKH
LHESLLHQLQDSVSKLEGHVQEHQLYQDLVADLNTTLENFYQKFLGFPDNLVDEKAAEEK
M-LTLQELEALLNLKGDTLEKILVLAESIKQNSSSVGQKT-IKDETDSLKY-KYKNLENR
LESVKEETENSFNSIL-KSKSEIKK----KEET-AMKKREEQVSSDTQDSIHESITVEKL
KERGEVKKVGELNGKNMNKKQPMIPHMKDSLLLSDCSPQPPIQGNIGESQTVQAEVSSKQ
EHLETIDTKPNPFEKNSVPESIELLKVREKSDVVLVAHKSQRESATNNLKNDQTNDQISH
ITNVIQEKLITNQKSLEDLETKDPLTTEEQVASLEKSMDINDQAYKRIVQDFQLWLSSKE
QLLDFIKQGEPVTEKTLSIFE--NSSLEMLLSKQLSPEAQESMKNIEDEQRVNELQNQPL
DLDIISANEQLKEIEVLYRQLEAKKANIGSQEPIMLPHNTETSALNVKNIQHSENQLDRL
LQALVTLKEDKERQYCLIKDFQDHLLAIKSSVKALSMEKENTKA-ASMESKQQLKKLEKC
LESIHKEKDSLSKLKEEQENLSSHLSEMDKKLAEKQVKQLELCWEQVEQWIQKKYSQQGA
EWDEFQCLMNKIQDMENSL-Q---DHQQQQQLKLNSPPELEEHKDLMFLATKLNIIKNNF
SLLRGRVEHQMKRIWGKKEKKKLETAISNLQEQLEEL-EPLTKEKY-----SQMKNCKIM
KKIQEAMLWVNNLLIGLDQTAALLPDNIVSQIKKHKMVHNEVLDKQPIIESLIEETKGVI
PDLDQCEATDLNTFLDELQSLNQALVSKCTEIAEQLETRLEERSTFFEKLGKVQSSLQGK
EVLITPEIKTAS-SKEDLDQYLVTLNDTQKELQNTDRLISTHFQEATDFSKCLNIFEQIF
LIDQLRNLKNKARWTQRLMQNKHHEVRKKLDIYTEFFEKTDMLQQELSQ--IRNHALL-L
NR----KPNHGTKEEICELRERTSVLQSNIIQIMKHKDIFESLGLNWDSSHLD---KVQA
ELLKIITELEEKTEQLERVNIENVKLQTSLNELQMVTLQIKKELAEIVNDTSFSP-ESRL
LSAQILSQRIEKATYLCQETIDLLSANETNKESFKQ-EIPQIRLLAEENNKLHKFL-QNV
VENFQPRSVGEKDFRDQLECALLVLTEVNFQLQQPLEVGLEIKHIQEEKDNCEALQKRVK
AELCQIKAITVKEYPRQEDNSH-ETRDLESKVNELEDLQLQFDKGFALRMNILDEALENM
KHFNKAVTRAVGLINSFKTKVNSHKIDLDNLGESQQLTDWK-QEEFKALIVDLKNLTSKL
ENITGPKDKVQLEHVLCEIINSYSLIKESAETKKADLE--RCL------KSYEGFNKTKQ
KICAILNKVEGGLQQSISQEAMSYREALERLEQSKNFVSDLVSTQEELTKLRQDFRCLRF
MCTENDSICLLKTVSALWERWLSLFENAREWEMFCEELKQDWKFVSEEIEREAIILDNLQ
EEFPESTKPKEAATNKELSEALECFCQYEENLEREQLLFTLLLHRIKNILSVPESLEITE
S-VPVLQEIRSMQDRCTKLSQKVQGNKELIQLEIEERNNISKEIMSLKNSLEKMTATFRD
MPLEEHPEKEDHMEALQKIIDKEKLALENIMEKLRIKYSEMYTIVPAEIECQMEECKKAL
EDIDEKIRNEVLKSSPSYMMREKIEEINHGLQNVEKMLQQKSKNIEQAQEIQKKMWDELD
LWHCKLNELDSEVQDIVEQDPGQAQEWMDNLMVPFQQYQQVSQRAEHRTSQLNKAILKME
EYNDFLRNTETWIENTSSLLAGPTDYSSSKALSHHANTLQMA-LEDSEQKQNLLHLVYSD
LEEFSAIFETDDFAPIKLNQLSARVTNLQQKIIASLPQIQHMADEVIAIENEVKSIEKKV
SKIKAILF-SKEIFDFSPEEHLKHGE----------------------------------
-VSMDCFLIYFNDCF---------------------------------------------
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-MWGILKAKCVELNSPSISESQYEDLLRGFAELVAIGREKMAQDPKHLTKSRAALQSHLK
NHKDFFHNLMTRMAYMEVFSTRVSPSVLQKREEFWRELVNEVKLLEQKACQYGIHLESLL
KDWMVFDEECLVFNKELEALASTLPSVSLVEETEERLMERIALLEKIKSSVDEKHARLYQ
MVKEGKKLLTAVSCPEIRSQIGKLEEQWLSLTKKVGHELHRLQTLLKLLV------SYNR
DSEELMKWLDSAQQRMNFWKEQSLNVSQDLATIRDNISSLFTFSKEVDEKSSLKSSVVST
ASQLLHVKQADTAALRSSLANFEQKWGELITQLPAIQEKLHQLQMEKLSSREAIAELMAW
LDHVEQQQEREEPINSQRGAAQVKTLLQKYKEYMMEMNFKQWMVDFVNQSLLQMSTCDVE
SKRYERTEFAECLGEMNLRWHRLQASLNRKIQDLEHILEDITENENKAQTLHNWLEAQSD
RLRSLQTPASLISAQNTLDDCKELENQLVAKSKILDELKQSLA-SNG-SAEQTPEAQSLR
IAELCEMKDSIVNQVAQLKASMESILEQWRAYDEIYAEVSLMTTRYLYCIDQCKPSGEEA
SLEALKKQVKTLQALQDESENNEESWAKFQAAASNLKKNCSPSFAEIIDQKCTETH--TR
WNSVNE---DITDQLRAAQAALQLWEPFDALCTETAAKLQQYSQQCAQLLDAHVPEENTT
ETLEQRIQEMK-NLQHGLQSIAGSRTQIYLQADRIKQ-QAGTAAEAILMEKLQPFQRATY
LEKMLQRKLDELQFNLLQLEDFNNCLETLEGRV-KNCTDTFDSLCLE-E--GDNSELLLN
QTLELAALSPSIESLNEASIKLPLSDFTMKKMQSLTRQWSQKTAAALILFYSMLDGTQND
-EKKFFQKCEKWMKFLEKMKEALKTDIPGQFEELQEQQRVYEMLQTEISINQQTFNSIIE
KVLFSLESGEAEKRTEFISKLTLLKEQWQNVIRMVQQRKKDIDGLVSQWQLFR-SSLQ-S
LSRFLDDTNSFLAAVKSQDCYSLYQLRNVIHDFKSKAVILQRWQAMYTLVIDVGEKLRT-
-VCDPDTSSALQEELSQLQQRWGQTQALLEKKKMQFSGTL-QTCDRFEKQTKELESRLQE
LKEKVKDPLPVEHEELHKAKEHIKELEQSLADWAHDMKELQAMKAELAHLILTEDMMVLK
EQVEHLHRQWEELCLRVSLRKQEIEDRLNAWIVFNEKNKELCSWLVQMESKVLQTADVSI
EDMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKSRVAEIDDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHTAGVESVFNICEVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQRFLDDYSRFEDWLK
ASENIAARPNSSEVLYTHAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVASILRRLKHFTNRRDEFEGTRESILVWLTEMDLQLTNVEH
FSKSNFDDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAILIEDELEELHRY
CQEVFGRVARFHQRLTSRDPGLDDEKDNSENETDQED--SREIQNDPWHKKAITEG----
PSSPQSLC----HLMPPTQ----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEAQYYSALSDVEITENPEAYLKMTTKTLKASSGKSVSEAHP------
------------WHSPGSPVCRKHRYNQAEMVGNVLS-GPETSTPYKPDYVKQLSSASS-
SS-SKEKIPSANMSDEEPQ-DD-QELVNITA-AEKQSGIIDRWELIQAQDLRNKLRMKQK
LQQWQQLDSDLSDISAWLDKTEQ-ELEELQKVKLPTSMQALEQKVKKLKDMLKAFDNYKA
VLLSANLSSKEFQKADSTEFKE--LQNRLRKVNLHWEKATRALDSWRKGLQQALLHCQDF
HDQSQKLILWLASAESRRNEAQ-I-TDPNADLNTILECQKELMQLEKELLEQQLNVNSLQ
ELTAYLLLKPDG-DYIEEEEKVHVIGTKLKQLIEQVSHDLKTIQENLDTKT-FLLV----
--PD--DLD-SGA-YNPEEEKPSPAV-KKAN---HEGQREN-LTPS------PLGSESHP
QPVQANPQSPSFFYRVLRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

--------------------------------------------------EQEHTQKKTF
TCWINSQLAK---------LVTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKKRS------IKLINIHVTDIIQGNPSIILGLIWTIILHF HIE----ELARTLG-K
YSQ-----PSLDCVGVV-D--SSPTSSPPAKKCSK--AQARWQMSAKKALLLWAQEQCAT
-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFHKDNL-E AFSIAERELKI
PKLLEPEDVDVINPDEKSIMTYVAQFLKYSKDTPGTGDKAEG-KVKDAI--------VWL
TLQEKKLQAVLKNSENETYFKKYEN----LLSFLESFNGEKKPFLDILLMKRNPDELNED
QLQLEKAWDGLNHQINEWKTQLSYVLPSPLHQIEAWLQEIEKLVDEDLPTFQDCSEAMTL
KQERMTLFKSLMDKFDCHSNTLMAFENRDEKYLPLIPPKKLEEMK-RRI--NILGKNCIP
HLEFHCHMCPVLGLLDEMKSKLDVWNIKYGSKESVELLLEDWHKFIEEKEFLVHLETSFQ
KCQER---NKH------LAEEYKNINKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXX----------X-XXXXX
XXXXXXXXXXXXXXXXXXXXX--XXX----------------------------------
--------AGEEHEKENEGLTGQLKVVGEVEKLIGQ------VEIWEAETKSVLDLLRHQ
DDMD--APMEESLQHLIAKGSMYEELVARTEDTLQMDVQNISSQES---LQHVVTAGLQA
KIQE-AKEKVQINVVKLVAALKNSTDI-SPDLDVRLKVEELQKELESYITRAEQLLGQRE
SPRALISQYKEALIIFNTKSLAKYLKAVEELKSNVTEDVKLSLEEKSKDACAKWESIHHE
MSLYIQQLKIDIEKGKLNDSISKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEMKRVLKDYEQKIEKLRKSASEIHKTL-----QP
MVG-GI--SKSKWTMNTSENGGRDAHSEVPFAKSDDQPSAEK---X-XXXXXXXXXXXXX
XXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-VLKNETDTCWKEFEIISLKLENLVSDMKKP-VIAKARDRLKGKEGELQMTL
HARMESLENALQIVLPVEKETLLLCDLD-LLLCEMAIQEFNLTDADGIYQRLKXXXXXXX
XXX---------------------------------------------------------
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----------------------------------XXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-------XXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXKKSLITLDKDLDEYEEEKKDLQEMVNSLPQFKGDRENILKQQCQNTVLLWENTKAV
VTECLEQCERVLELLKQYQNIKSVLTTLIQKEENIISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEDIDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEEFYENLS
RALALWDKLYNLKNVIDEWTEKVLRKVELHHLTEEEREGLKXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPELSELKKQYESVP
DLFNTKKSVLQDHFSNLLNDQCKNFNDWFSNIRMNLKECFEISETKKSVEQKLQKLSDFL
NLEGRGSKIQQVKTVLNQVKKHLPKAHVKELNSWIASQEFELEKMESMCQARAKELKDYL
QQLLRLQDDHRNLSKWLSNQEEKWKETEESGEKTELFYQALARKREQFESLTQLNNSLKE
YGL-TE-----EELITESTHLNDRYQTLLRQLCAIEEENKLPPAEDQCFNDLASDVVHWI
TEIKESLMVLNSSEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXX------XXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXVSVQKLDGHVQVLQSLLVRIADRNSSSANLWEEVSMCDKPD----QIAEE
K-WKWQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------XXXX--NSAVEMVLSKQLSLDVQESMKNAEDEQKVNELQNQPL
ELDIMLRNEQLKEIEKLYTQFEAKKTAIEPLRQIEHLSETETSPLVSHNIRYSVHHLDSL
LQTLVTLKKNKESQYCLLKDFQEHLTAVEFSMKALLTEKESLKV-GPLDSATYLDKIKNF
LASTEKEKASLSKLEIKWENLSSHLTDMDKKLLERRIRQLEHGWEQVEQLVQKKYSQQVV
EYDEFRSLMNKVQDIEISL-Q---QQQQSLQLMLNSPGEQEGNQSVVSLATDLHVLKHRF
SVLKGRAEIQMKRIWGEKEKKTLEDAVNNLQKQLEAV-EPLQLEVE-----NQIKKCELI
YKIKETILWVKTLFDELIPTISLLPDGVLSQIRKCKVTHDGILDKHQFVQSLVEEVKDNV
PNLAAYETDDLNDLLQDLQNQYQMLVLKSTQRSQELEYKSEERHNFLSTVGKVHLSLQGN
ETLIIPKMETTP-SEAELEHQHVTLKASQKDLQEIESIISTHLQELTDFCKDLNVFERLF
LADQLKNLKTRANRTQRFIQNKCDEVEHKIKLYREFHEKTSVLQKEVDS--MQHNELL-L
NK----EINPDVKEEFCELKDRLKVIQSSILQVLKLKEVFDIIGLNWDCSQLD---QLQT
QVFEKEKELEEKIKQWDTFVEERDKYQESLNKVRAMDSQIKERAEAMLKMPNISQ-ESSL
LNAHILNQRIEKAMCLYHEVIKKLSENKAFDESFKEKEILQIKLYVEENCKLQNVL-QNI
ILEFQLKEMDEQAFQDKLRNILHVLNKIKSQLQQPLLTNLEIKHIQNEKDNCEIFQEQVQ
AEIYTIKALTVTQKQKEKENSS-EASDMETKLCDIEDLQTQLNTSIVWRTEVLNDAFETM
THYNDAVTRAMGIPTALEAVSS-HAVDLDNPEESLEMPRRK-LEELESTMADIQALTEKL
GTISSPEAKLQLQSALQELVSKNSAMREAAKEEEAEVE--RWL------KDYKCYGKIKE
EICSNLSRMERVLRQSMSQLPVSYKEAIERLEQSKXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIEREAIILDKLQ
EELPEISKTKEAAPTEELSELLDGLCQYEENVEMQQLVLTLLLQRIKSIQNVPDGIGSVE
T-VPAFQEIASMQERGNKLLQKVQKNKELIQTEIQERHSFKKEIIALKNLFQQTATSFEN
MALQDHPEKAEQFEELQSVLKKEKLTFENIMEKLRIKYSEMYTIVPAEIESQMEECRKTL
EDIDEKISNEVLKSSPSYAMSRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
DYNDLLKSTEAWIENTVRLLASPVDYDSSRAVSHHASTLQMA-LEDSEQKHNLLHSIFTD
LEDLSIIFETDDLAQ-SVQQLSSQVTTLQQKIMESLPQIQQMADDVVAIETEVKSMEKKV
SKIKSILL-SKDIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVPYQVKLRLPQTGIKPLPVFQRTNQLLQDIKLLEHVTQEQNEL
LKI-VIKQTNEYDEEIENLKQILNNYSAEFSLEHMSPDQVANLPQVQX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX-XXXXXXXX-XXXXXXX-
--XXXXXXXXXXXXXXXXXXXXXXXXTGDKKTEPSSIS--WTLLWEHDKDK-EEDRA-ST
SSGTIIQE----VSEKISKYNRSMAPVLAPDSLDTE---QGPEFSLSPSQKKEGATPPIK
AEGLGFPGKQG-AFEAAV--ESSRPEPAEILHVCKTQVAKLELWLNQANVAFEPETLNSD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGAIQQEAEALSLKLKTVKCNLE
KVQLTLQEKHSEDQ--HSTIVKKP--S--EHQKVLQPDNLSAFGSIVTERPQFSRQKDFQ
QQQ--VL-LKPMEQKDLV-FIEFN-TKKIWPQYCQXXXXX-XXXXXX---------XN-K
AASSQNDASNSVLSAQGQ-NGDKWLY-----L-QHELSTKIRLPLP-QLVEPQVATNMSV
LPSVCMYNFRYPTTEELKTYTTQLEDLRQEANNLQIQENMTEETYINLDKKLFELLLTLS
QYLSSVEEMLQTPALFREDSCAQQVHF----KTLALELKKLHLAMSDKKTDLSKAMTYLG
RNSSLFLECFDDLHVCLEHTQATAASRSKSLKAGLDYNRSYQSEIKRLYDHLIKNKTSLQ
QSLNEISGQSIGEQLQKVDSYTVELQNSEGRVAKLRDEGERLHLPYVLLQEVYKLEEVLD
SMWGILRARYTELSSPFITESHQDALLQGMVELVNMGREKLARDHLRQTKSKVALQAQIQ
NHKVFFQKLVADMLLLQTYSNKMLPSLLQKKETFWAEQEKEVKLLEEKSHQCGMKMQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKCLVASVSCPELDGQISKLEEQWLSLNKKIDHELHRLQTLLRHLV------SYNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRP--INSFEFSKEVDETSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSR-AITEMISW
MNNVEHQTADEDAVRSPSSASQVKNLLQKYKXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXDIENQLAIKSNALDELRRSYLTLES-GTMPLLEDTASK
IDGLFQKRSSVISQVNQLKTSMQSVLQEWKIYDKLYDEVNMMTIQFWYCMEQSKPVV--L
SLEALRCQLQKLQSLQDEAESSEGSWKKLQEVIGKLKDHC-PSFAEIIKDKCQDTH--AR
WTQVNQ---DIADQLQRTQSLHQLWMVYSSAHTEATARLEQQEAKYQQLASINMSGNNLA
EILTPALQDIK-ELQHDVQNTKEAFLQNSALLDRFPQ-SEESGTHMLLSGHLHSLQRATY
LEKMLLVKANEFEFVLSQFKDFEDRLESLKGLI-TCEEENLDKLYQQGK--EDNPDSFMD
HVLALTAQSPDIKRLNEVSLKLPLGDMAVKTLQNMNRQWIRATATAL-ERCSELQGIGWN
-EK-FLYCCEKWVQLLEKVEETLKVNIAGNLPALLEQQKSYEMLEAEVSINQTIANSFVT
QSLHLLDTTEIEKRPEFVSKFTMLKDQWQSAARRVQQRKGDIEGLVRQWQYFS-ESVD-D
LLRFLTNTSHLLLAVKSQDGYSLCQTRSLIHELKNKEIHFQRWQTTYSLTLEAGEKLLN-
-TMNVETKELIDKKIGQLQDSWKNTELQVKEMIKQFQSIV-ETWDQCEKKIKELKSKLQV
LKAKCKDPLPELHEDLHKEKELIKELEKSLANWTQNLKEVHRMKADLTGHILVEDMMVLK
EQIEHLHRQWEDVCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EISLFSENK-LQLKQVGDQLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDN-MSTF
RTWLARI-XXXXXXXXXXXXXXXXXXXXXXXXXXDLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSVERRMKIEETWRLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTIAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQTVHEGNQRWDSLQKRVTAVLRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLT SHAPGLEE---ASENEADMED--SREMQSDSWRKRGESEE----
PSSPQSLC----HLVPPTP----AHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSXXXXXXXXXXXXXXXXXXXXXXXXKSISDGHS------
------------WNVPDSPTCPKHHYKQMEGDRNIPPIPPDSSTPYKPAYIKLLLPPGT-
DGGKEG---PGVLNGSPQQ-ED-KELTG----QQ--SGAFDRWEQIQAQELHSKLKIK QN
L---QQLNSDICDIATWLEKTEA-ELEMLKMAKPPSSIQEMELRVKRLKEILKAFDAYKA
SVVSVNVSSKEFLQSGDTESEE--LQNRLRQLSLHWDTAQGSVDSWRQGLQQSLMQCQXX
XXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXXXXXXXQLEKELVEHQPQVNSLQ
EISNSLLIKGHGEEYI-AEEKVHVIGKKLTQLLEQVSQDLKSLQRSQSPDP-SLPS----
--FD--EVDFGAQ-HPAATSVPAPQA-KFGA----ERTTKGKSKTD-------DRVPGPT
SPG-SSRPQRSFLSRVLRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKVLLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDAWRSSVLYRIYMPGTVSYASYL------------------------------
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-

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--------------QTAL--DGGRPEPESILLLCQAQVAELEQWLAKTKMSLGSAPQSPR
RQQMVEPQLADCQVRLSEIEQKVLSLLEDC-----GDSADYQRKTEALSLKLKEVKSNLE
NVQMMLQDKHSEEQ--VPSRERID--P--EPLEILHSDGFSTSQLPLAQQPW--H-KGLQ
QPQ--DLKLKAAEQKSLIDFIESC-VEKM---QPQLEDNV-SPKSES---------SN-G
ESDSKSKQADATLAPKDQ-MGNKWQY-----L-QQELSSKMKSPLC-QLVEPQITTKMNV
LPRGTFSGAGTPTVEELKTYTVQLGDLSQEANVVHAQDNVAEEVSSNLDRKLFELLLAIS
RCLNNMEEMLNTSVLSAEEAAVQQALY----ETLSVELQKLHADLSDKKDDLLKSISCAG
GSTDVFCECFNNLQARLEQTQAATASRSSSMKAGLDHNSNYLNQTRLLYDQLTEKKAALQ
QCLNELHGHNVSEQLQKIGDCAVELQNFESQVAKLRGHGERLQLPITLIQEAYKLEDVLD
DMWGILKAKYVELNSPAISESQYEDLLRGFAELVAIGKEKVAQDPKHLTKSRAALQSHLK
NHKDFFHNLMTRMAYMEAFSKRVSPSVLQKREEFWRELVNEVKLLEQKACQYGIHLESLL
KDWMVFDEECLVFNKELEALASALPSVSLVEETEERLMERIALLETIKSSVDEKHARLYQ
MVKEGKKLLTAVNCPEIRSQIGKLEEQWLSLTKRVGHELHRLQTLLKLLV------SYNR
DSEELMKWLDSAQQRMNFWKEQSLNVSQDLATIRDNISSLFTFSKEVDEKSSLKSSVVST
ASQLLHVKQADTAALRSSLAMFEQKWGELITQLPAIQEKLHQLQMEKLSSREAIAELMAW
LDHVEQQQEREEPINSQRGAAQVKTLLQKYKEYMMEMNFKQWMVDFVNQSLLQMSTCDVE
SKRYERTEFAECLGEMNLRWHRLQAALNRKIQDLEHLLEDITENESKAQTLHNWLEAQSD
RLRSLQTPASLISAQNTLDDCKELENQLTEKSKTLDKLKESLA-SNG-SAEQTPESQSLR
IAELCEMKDSIVNQVAQLKASMKSILEQWRAYDDIYAEVSLMTTRYLYCIDQCKPSEEEA
SLEALKKQVKTLQALQDESESSEESWAKLQAASSNLKKNCSPSFAEIIDQKCTEAH--TR
WNSVNE---EITDQLRAAQAALQLWEPFDALCTETAAKFQQYSQQCAQLLDAHVPEENTI
ETLEQRIQEIK-NLQHGLQNLAGCRTQIYLQADRIKQ-QAGTAAEAILMEKLQPFQRATY
LEKMLQRKLDELQFNLLQLEDFNNCLETLEGRV-KNCTDTFDSLCLE-E--GDNSELLMN
QTLELAALSPSIESLNEASVKLPLSDFTLKKMQSLTRQWSQKTAAAL-ECCSMLEGTQND
-EKKFFQKCEKWMKFLEKMKEALKTDIPGRFEELQEQQRVYEMLQTEISINQQTFNSIIE
KVLLSLESGEAEKRTEFISKLTLLKEQWQNVIRMVQQRKKDIDGLMSQWQLFR-SSLQ-S
LSRFLDDTNSFLAAVKSQDCYSLYQLRNVIHDFKSKAVILQRWQAMYTLVIDVGEKLRA-
-VSDPDTSAALQEELSQLQQCWGKTQALLEKKKMQFSGTLQQTCDRFEKQTKELESRLQE
LKEKVKDPLPVEHEELHKAKEHIKELEQSLADWAHDMKELQAMKAELAHLILTEDMMVLK
EQVEHLHRQWEELCLRVSLRKQEIEDRLNAWILFNEKNKELCSWLVQMESKVLQTADVSI
EDMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKSRVAEIDDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLKETFSFIQLLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHTAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQRFLDDYSRFEDWLK
ASENLAARPNSSEVLYTHAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVASILRRLKHFTNRRDEFEGTRESILVWLTEMDLQLTNVEH
FSKSNFDDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAILIEDELEELHRY
CQEVFGRVARFHQRLTSRDPGVDDEKDNSENETDQED--SREIQNDPWHKKAITEG----
PSSAQSLC----HLMPPTQ----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEATYYSAL-----------------------SGKSVSEAHP------
------------WHSPGSPVCRKHRYNQAEMVGNVLS-GPETSTPYKPEYVKQLSSASS-
SS-SKEKIPAASMSDEEPQ-DD-QELVNIAG-AEKQSGIIDRWELIQAQDLRNKLRMKQK
LQQWQQLDSDLSDISAWLDKTEQ-ELEELQKVKLPTSMQALEQKVKKLKDLLKAFDSYKA
VLLSANLSSKEFQKADSTEFKE--LQNRLRKVNLHWEKATRALDNWRKGLQQALLQCQDF
HDQSQKLILWLASAESRRNEAQ-I-TDPNADPNTILECQKELMQLEKELLEQQLNVNSLQ
DLTAYLLLKSDG-DYIEEEEKVHVIGTKLKQLIEQVSHDLKTIQGNLDTKT-FLLV----
--PD--DLD-SGV-YNPEEEKSSPAV-KKAS---IFFSSACCSLFL------LFRSESHS
QAVQANPRSPSFFYRVLRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

--------GCFPQLPDKGG-SYFLGTISHLSF-----KMQ---------VQRECTQKKTF
TTWINSILAKHTPPSVISDLYTDIQQGHMLLDLLEVLSGQHLPREKGCNTFQCRSNIENA
LTFLRSKS------LKLINIHVADIIEGKPSIVLGLIWTIIFHF HIE----ELARTLACT
YNQ-----PSLECSSTVD---SSPKARRSAKKSAK--IKERWKI SATKALLFWAKEQCSL
-CGS-ISVNDFKSSWRSGLPFLAIINALRPGLIDLEKAKARSNKENLDEAFRIAELELNI
PRLLEPEDVDVMNPDEKSIMTYVAQFLQCSRNMPET-EDMQG-KVTETV--------SWL
AVQGKKLANLLMDTENETYYQKYKE----MMSFMEAFNREKKAFLPLLSSKRSGAELSEG
QQQMREEWSKLISQINEWKAQLDQMLPPPLDGIEAWLQKVEHLQAEDLPDLQDPFKAMSL
FSEIISVFKGLMNCFDSHLETLQSFENKDENNMPLVVPEKLEEMK-RRF-NDIRFTNSSS
LLEYHYGLCSA--FANEVTLKLNIWDVKYGTKESVESLLENWNNFIKEKRLKTQLETAAD
ICEDL---KNKN-----ISNLDLEISKLFKTVESKISMCKDYISNVNTTLQKVLSSWSSY
TEKLYLLKTWLEEKQNEYPIE-----VPAEVLANWNSVHASLNEAGNYLIEVSKEQVGSN
IAKELKKLNRKWAKFIKKTRFVSQLSI-S-SFKTRGTENTQRYPIRKSLPLSIS-VG-DE
LNENVNK----------------LGE----------------------------------
--------ENTDTAEKARELPGGM---EKIEELLGS------VESWATETECLLSETGHK
TPVE--PQMEEYLQSLAAKGISYQEQVLAVEEILQSLMKNASSQVS---QQHCHTTGLPA
RIKE-ARDRIEAVMGDMNNILPKSEKK-PSQREALLNFEESQKDIEVSISKAVELVSQKL
SREVHISRYEEAFNALDNKVLDNFLKAVEQLKSISSDQEKLAVEEKSEDIRKRWEAAHNE
IISCVQ-LLLEREKKKFNTTFKKINKQLGKEKKLLNMNKTKGLIKEHE--AFFSHEGSLK
ELSKSLEDLKILGKL-----AEETVPDLQTFAADSEQKLEKLQQTVADTYTAL-----LS
HL--KF--LLNHRSSIVASENGEKPSSTQQIDILSVQETSRP---S-----EDMALETDM
KHHNGESCEKMFEEGSDSPTPALLESYNTQRRNLEELLQVSRDKVASGFTDEI-KGTSCL
QNKLLELQ-MVENDINSGWAQLGNISSTLENLVDEVKQA-AISETRGKLEGELKELQDII
STRTNSLRTALEIVLPIENESILLCELD-QRLNKKGIQQFNLVNSDLAYGELKE------
-LQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------RSILNQIEVCKQL-EHLDSSARDEFN
PIDLQAASKIMFYYQNQLEEMSHKMQIRETVLKDLEAFMASLRKIKSSVKHLIDPLGKPE
IQ----GKTRREAAQELSHMAK-EAQCLDERLKTVDICLEDAECGRNTSCEKLLQTLSEE
LNVTGDHSSEQMLMEGNDLYRV-------FSTRNEELLKNIQDLRDRINKIGLKDPTVPA
IQQRVKSLMELEKELDCSAVEMKSMREIANKLLQMEEEKAEESNEQCRVTERSWEDTKLL
LAECQEQCTRALELLKQYQSCKSSLTSIIHKQEIVLSQQNSYMGKDNLNRLITKIEEAKE
EFNDHAEDVDKINQICKNLQFQLNKMRSFEEPPFENEANIIVDRWLDINEKTENYCDNLG
RAQALWDKLLGLSGTIDAWANAELKNTEGRCLTDEDLTQLKACLSVQEQKLQKFDNTVAE
IEELLNSNEPPLELQVIRSSIVQKMELIKDLLTAKRRTSELSVNTAELKGDLDLAKTQIG
MTESLLKALSPSDTLEIFTKLEEIHQKILQQKHHVTLLQEETDC--PDVDELNKQLKCVT
DLFNKKKHVFQDHFIGVLNRQCKNFNDWFSSTQLSLKDCFDPSETKQMLEEKLQKLKHFF
TSEGKDGDIQEVKTLLNKVKHYLPKASINQLSSRVRDQEAELQRLISKCQKREKELGTSL
QQLNSLQESNTVLEKWLTTQEEKLHEIKKDEIKLENLYKTLLMQREPFDSLAQLANSLRE
TGL-T-E----DEIISETSSLVSRYQTLMTNVNEMAGNTQGLAVD-ENFKELTQDMSNWI
KKLEKAINNLSSQESELAPDERINQIKEIMALKDAGDAKIQNIVSVGEMLIRNDKIKKPE
I--QQTVSDLQNQWERTCQLATAYRSPQEQLLFNREQYEQSKDDLRLALTELKKQHQEMD
FALQPGLLEKQAQLASYTKLLQKAEDLTSQLNELESR-DHVQSFAENPRFTEESWLELKH
QHENLLSQLQAAVETLERHVQEHQQFQDMVTVLNTEIKTVSKKLADYVSPTVEQTSTEQK
Q-LKSQEQEAPLCQFEDMLKKILVLAETVKQNTSSPGQKF-IEDEIETLQS-EHRSLEEK
LENVKQKKENIFSEAL-ELKDDLTDGVQMENK----LKREMQIISDTPVAAEEGTTTAEL
RECLEMPT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------KEGAAGVDQKELFPGVQVNTEYFEEEQKVNKLKNEVA
ELDIVLINEQLKELENLQTELETWKAKSLCLSQETFPDATRSNGAELQSPEPVVPCWDRL
LQELDAVKAVKQQQSCLVNEYQKNLSAAQSSMKNLATEKDNIKM-GPMNNTVLLEKIKAC
VQSLHKERDVLNRLKTQQELLSQHLTCMDKVLTASKMRQLEQWWQHMEQAVQKKHDQVLA
EINEFNTLMDKAQDIQRLI-Q---E-QY-LQTESCSSAGEKAKCPII-WTAELQNIKHGL
SLLKRKIELQMQRIWSDEEKIALESCIQDLQSKLEALSEQHTPQDEVRVTGPAVKKQDIM
KKLKENVSWVKDSLSSLDQKAALFPCDVKSQIRNCELMRNEVLDREPVIEALGNELQHIL
PNLKPEEISDMTFLLQALQNSYKALVLKSVERLQHLQLQLEERQRLTAEVEKVHCQLRNA
EALGRPDMNQTS-TCSELISQQDILKEILKDVQEIEGLISSHCEESQITAGELSLSEQLF
LIDQLRSLKNRARKTQRQIQSKCHEVGKKIAVYREFAEGITSLQKDLSD--LQCSELK-L
EE-ELTGATQEVKNKCKALKEKVLSFQSNLSQIMKFKEIFECIGLNWDSFQLDELHELQT
QFFKIRNKIKGKITHFGNVIRECDKFHALLNEIRTMTSAVRKEANILSDRSNSSP-AENL
VSAQILLQTVQQILYLIQEVENQINKNEVFHTLFKESKRQEIKSLETDVEELNLFL-QN-
-LVSSLQCVNKEDIQNVAEHLSHAIRHVQLELQQPMVVDMK--MMQYEKMRWESIQNMMS
AEFSAIKCIMEKERGSQEEKS--LAAGVETKLRALADHEIQLKTDIAARVSALEEACKAG
ELYTKAVERAAKFLEDCEAQVRSAAVELSSSEDAYQTPQWK-QEEFDSAKADIEQLYSKL
KNLVKPEDKICLENTLRELINKSLALKGKIQRNEADKQ--SYL------EKYKSYSKCKD
KVCDDLNNLGKMLGQSLSQTPMSYKEALENLQECKILVSNIDSAEDDLVKLRQVSGELMR
LCKGSDRAL-GRIVTALWENWLGLLEAAKELEINCEELKQEWKFINEELEREAIILDKLQ
EEQPESLKEKEKATREELVELLDSVYAFEENISRQQLLLLLLLHRIRNILNTPENVEAET
A-LPALCEIKTMQDRCKKLFEKTQDRKNLIQSEIQERSKITEEINAVKNALQNALSVLSQ
DAV----GKAAQLKEVQSVIDKESQNLKDIMEKLRIRYSEMYTIVPAETEAQLEDCKKTL
QDLEDKISFENLQSSPQYVLKGKAETINNGLQAIEKMLEQKTESVAKAKEVQKQIWDMLD
LWHYKLNELDAEVHDIVEQDSCHAQELMDILMIPLQHYQQVSQLAERRTAILNKAANKME
EYDELLKDMKVWIENTNSLLRAGAQNDSAKRLHKYTDGLQMA-LEDSEQKQNLLHSVYLE
LEELTPVFETDSIMQ-QLNEAEEEVATLQQEIAEILPQIQHVADELDAIESHVKMFEKDV
MKMKTILS-SEDLLELSPKDQLKHGQ----------------------------------
-VILDHIGPMQKTIVHIQSYEEDLQLPGVKKQPVSVFRRARQLLRELKKIEKITKEQNEL
LEE-AVKKTEECEQEIEKLKQFLKNNLAEKSHEYQPHTQKTSCPEFQG-EMEAIKEEIIK
LCQRKEDILTGMKNSMSELHQRLQEEVPEPG--DEPTASAFG---DSI-----GTDVSDV
QLKKRGLMSLLPCLDEESED-AFHSKQEKGSTVTEIDVSFWPSLKYKEKHK-EDSAT-SW
SSGTLSDGGAQVMNSAVIHSINSWGGSKMKRD-GVL---SAPFASKGDESV---TPPPVP
NATQGPRGKEG-DPEEAV--DGGRPEPGTILQACKAQVAELEQWLDKTKVSLGSDPQTPK
MQQMVELQLGDFQVMLSEIEQKVLSLLEDG-----GNSAGHQQEAEDLSLKLKEVKCNLE
KVQMMLQDKYSEEQ--IPNRERID--P--ESLKMLHSNGSSMPQLGLAEQPFLQQ-NGFQ
HPQ--DLKVKAAEQKSLIDFIESC-VEKM---QPQFEDSV-KSEPRYKATKSLPRFSN-G
ESDPKSKKADPTLAPKDQ-TGNKWQY-----L-QQELSSKMKSPLC-QLVEPQITTKLNM
LPRGVFPNAGASTVEELKTYTVQLGDLSQEANVVHAQENVAEEVSSNLDKKLFELLLAIS
RCLDNMEEMLNTSVLSTEEAAVQQVLY----ETLSVELQKLHADLSDKKDDLLKSITCAG
GSTDVFCECFNNLQAWLEQTQAATASRSNSVKAGLDHNTSYQNETRLLYDQLTEKKATLQ
QCLNAIRGHNVSEQLQKTDACTLELQNFENQVAKLRGYGERFQLPVTLIQEAYKLEDVLD
DMWGILKAKYVELNSPSISESQYEDLLCGFAELVAIGQEKIAQDAKQLTKSRAALQSHLE
NHKDFFHNLMTHMAFMQAFSKKVNPSVLQKRENFWTGLVNEVKLLEQKASQYGIRLENLL
KEWTEFDDECLAFNKELEALTSTLPSVNLVEETEERLMERIALLQQIKNNVDEKHARLYQ
MVKEGKKLLTAVSCPEITNQIGKLEEQWLSLTKKVGNELHKLQTLLKLLV------SYNR
DSEELRKWLDSAEQRMKFWKEQSLNVSQDLPTIRDNMDSLFTFSKEVDDKSSLKSSVVST
ANQLFHVKQADTAGLRSSLAKFEQKWGELITQLPAIQEKLHQLQMEKLSSREAIAELMTW
LDHVEQQQGHEEPINAQSSVAQVRSLLQKYKEYVMEMNFKQWMVDFVNQSLLQMSTCDVE
SKRYERTEFAECLGEVNLRWHRLQASLNRKIQDLEHLLEDATENENKAQTLCNWLEAQSD
RMRSLQTPASLISAQNTLDDCKDLENQLAMKSKMLDELKQSMS-LNG-GTEQTPEVLSFR
IADLCEMKDSVVSQVAQLKVSMQSILEQWKVYDDIYAEVSLLMTRYLYCIDQCKPSV--P
SLEALKNQVKTLQSLQDELENSEESWAKLQVAANNLKKNCSPSFAEIIDQKCTEAH--TR
WSSVNE---DITDQLRTAQATLQLWEPYDSLCTEAAAKLQQHEEQCTQLLDARMPEDNMI
ETLKQRIQDVK-NLQNGLQNIVGCRSQISELADQIKQ-QAGTAAQAVLLEKLQPLQRASY
LEKMLQRKLDELEFNLLQLEDFKNCLETLEGHV-KNCTDAFDSLHLEGE--TDNSELLMN
HTLELAALSPSIESLNEASIKLPVSDFILKKMQSLTRQWSQKTATAL-EHCSVLEGTQTD
-EKKFLQKCENWMKFLEKMKEALKTDVPGRFEELQEQQRVYEMLQTEISINQQTFNSIIA
KVLLFLESGEAEKRTEFISKLTLLKEQWQNVIWLVQQRKKDIDGLVSQWQLFR-GSLQ-S
LSRFLADTNSFLTAVKSQNCYSLYHLRNLIHDFKSKAVILQRWQGMYSSIIDVGEKLRT-
-DSDPETSAVLQEELSQLQQSWGDTQVQLEKMKTQLS SILQ QSWDSCEKHTKELESRLRE
LKDEVKDPLPVEHEELYKSKEHIKELEQSLADWAHNMKELQAMKAELAHCILTEDMMVLQ
EQVEHLHRQWEELCLRVSLRKQEIE DRL NAWTVFNEKNKELCSWLVQMESKVLQTADVSI
EDMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKSRVAEIDDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLK ETF AFIQLLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHTAGVESVFNICEVLLHD
SDACANETECDSIQQTSRSLDRRWRNICAMSMERRMKIE ETW RLWQRFLDDYSRFEDWLK
SAERTAASPNSSEVLYTHAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVAAILRRLK HFT NRRDEFEATRENILVWLTEMDLQLTNVEH
FSKSNFDDKMRQLN-GFQQEITLHTNKIDQLIVFGEQLIQKSEPLDAILIEDELEELHRY
CQEVFGRVARFHQRLT SRHPGLDDEKETSENETDPED--SREIQNDPWHKKAISEG----
PSSPQSLC----HLMPPTQ----GHERSGCETPTPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDE----EEATYYSAL-----------------------SGKTVSEAHP------
------------WHSPESPVCRKHRYNQAEIVGDVLS-GPETSTPYKPGYVKQLSSASS-
SSVNKENITSANMSDEEPQ-DD-QELVTITA-AEKQSGIIDRWELIQAQDLRNKLRIKQH
L QQWQQVNSDLSDVSAWLDKTEE-ELEELQKAKPPASMQAMEQRVKKLKDTLKAFDNYKA
VVLSVNLSSKEFQKADSTEFKE--LQNRLRKVNLRWEKATHSLDNWRKGLRQALLHCQDF
HDQSQKLILWLASAEGRRNEAQ-I-TDPNADPHTILESQKELMQLEKELLEQQLKVNCLQ
ELSAYLLLKSDGEDYIEADEKVHVIGKKLKQLIEQVSHDLKSLQGSLDSRV-FLPV----
--PD--DLD-SEV-YHPVAVKSSPPV-KKMT---IRRTSDG-RKNS------NTRAESHA
QPTHVVPRSPSFFYRVLRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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------------------------------------GKEKVSSSKDHQPMCNEALTSQLE
QYRNFFNMLDNQVILEQSYFSKIPQEELSK--DIQESLVYDTRSLQEEAEPHGIHMKSTL
RNWRDFDLRHDHFNKDLENLMSLVPAIGLVEESEERVTERIHQYQHIQRHIDDGESRLRQ
VIADGKKLITVVNCPKLETQIKKLEKQWSQLTQKVTHELHRLESLLKQLG------SYNR
DSAELSAWFESAHQRLNSWKLQSLDVSQDLETVRNNLTNFFEFTNEIDQKSSLKTSVLST
GFQLLRLKESDTAVLKVSLANFEEKWADLMAGLPAVQEKLQQLLMEKLPSREAIFELMLW
MDKAEYAKDTVDKEKKQKSASHVRSFLQQCKDFRKEMNHKQCIVDFVNQSLLQLSAGDVE
SKRYEKTEFAECLGTMNLQWHQMQGNLNRKIQQLERTLDITTEKENEMKALSNWFDVQQQ
RVEKLKRPISKLAAECTLADCKELDKQLIMKSRTVENLKKDLVPIVI-DDQSQKE-SCAV
TETLLKKRDSITSQVAELKSHMGSILQHWKTYDENYEDLNKLTVKIIYILGQNKPSV--S
SQPMLRNRLKRLQSLLEEVEQQEEKWIKLRLSMDSMADLCSPSVVVILQEKQSEAR--AR
WDTAHQ---ELACHIQAAQILLQLWEQYHNSYLEHTQKLEQLEEKCSELVYAKISEDKET
DTLQRKIQDLQ-EYNQALRELRSRVTQVLELADKVLE-QDPAASDIILSERLDSSQRIAA
LERRAASRSAELTLIMNDVKAFKKNLETIQAQV-QSSANIVSTIFLSGKEREEKSDVIKQ
QLLELSELSSDIEHLNEESFTLPLDDATLKLLLNLNRLWTKTTESAL-EECREHQINQME
-ENNFVQNYKALLHSLEKLEDNLTGGIAGTFVELKQQQCTYERLLAEIAINEHILPCFIR
KALTLLEA-EEENSSELILKLTALKEKWQSVISLVHQRKREIDALLKQWCFLN-CSRQ-R
LGNSLAEIQNDMASVSNEKCHSLFQTRKMTHDFKSKELHLSRWRNIYSTALDHGKDLVS-
-VAHPESKNALKHDVTQLQEQWESTQQQLQAILSQNTATL-QKWQSFAWTAEDRRNSLHE
QKLRINEPLPILHEELQKAKESIKELEESLAEWKQSLQELSNMKSDLSQYILAEDGVVLK
KQIEALHVQWEELCLRVSVRKQEIE DRL NAWNVFNEKNKELCEWLTQMESKVLQTADVNI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-HHLKQIGDQLIIASNKARATEIDNKLNKINERWQHLFDIINSR-------
---------------------------------------VKKLK ETL VIIQQLDKNMSNL
RTWLAQIESELSKPVIYSICNDQEIQKKLSEQQ-DLHKDIELHSSGVASVLNICERLLHD
TDACANETECDSIQQTTRSLDKRWRNICAMSMERRLRIE ETW RLWQKFLEDYSRFDDWLK
EAEATAASPESSEVLYTRAKEEQKRFEAFQRQIHERLTHLELVNKQYRRLARENRTDAAS
KLKHMVHQGNQRWDSLQKRVAAILKRLKHFTSQREEFEGTRDSILVWLTEMDLQLTNVEH
FSESDIEEKMRQLN-EFQQQITLNINKIDDLIVSGEHLIQKSEMMDAVVIEEEIEEMLKY
RQEVFGRVSRFHQRLTSRNLLLDEERETSENDTDAED--SRELQNSSWHSAI-HGS----
ETSHPSIC----HLMPPNL----PHDRSGRE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGTYFTALSDVEIPENPEAYLIMTTKSVQESSGQPDVKVTP------
------------WHSPGKRRSHRKHSEHEHTKGPVTA-TTGTNTTFDLADSV-MS-----
---------TAGIEGSQHTASS-AENEQQIS-STLHTGVIERWEIFQAQSLSDELRMKQS
LQQWQQLNSDFSDITLWLDKMET-DFNSMSKVKPACTIQELQQKVIKLKDTLKAFDNFKA
LVISANLSCKELQHENDSESGD--VLNRLHGVNLRWDKACHERDKWKESLQRELMQCEEF
HGTTDKLLLWLTKAEERRLRNK-V-TDITVDPDVLLERQNELLQLEDDLLGLQGQVNTLQ
DISCCLLNKTAGDEHNEAEEKVRVVGMKLRQLLKEVSQELQTAQQALDYSP-HH-G----
--ID--SLD-SGP-SES---QVTSYC-LFLL----FQAEVEAASKS------TARITEQS
SSVQEVPKKRSLFYRVLRAAFPFQLLLLLLLLLACMIPFSEEDFSCAHANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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-------------------------MAEDGGVDADLPDCN------CDV--IQ-------
---------------------------------------LPKLKETLVAVQQLDKNMSSL
RTWLAHIESELAKPIVYDSCNSEEIQKKLQEQQ-DLQRDIEKHSTGVASVLNLCEVLLHD
CDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE ETW QLWQKFLDDYSRFEDWLK
TSERTAAFPSSSGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSAC
SLKQMVHEGNQRWDNLQKRVSSILRRLK HFI GQREEFETARDSILVWLTEMDLQLTNIEH
FSECDVHAKIKQLK-AFQQEISLNHNKIEQIVAQGEQLIEKSEPLDAAVIEEELDELRRY
CQEVFGRVERYHKKLI-RLPLPDDEHDLSDRELELED--SAALSDLRWHDTSADSVLSPQ
PSSNPSLS----L--AQPL----RSERSGRD--TPASVDSIPLEWDHDYDLSR-DLESAV
SRTLPSEDEEGQEDKDFYL-RGAVGLSGDPSALESQIRQ-----LGKALD----------
-------------------DSRLRMQQTEDIIRSKTPTGPELDASYR-GYMKLLAECS--
GSIDSVRRLEHQLKEEEE--NF-PGFVNLNSTEAQTAGVIDRWELIQAQALSKELRMKQN
LQKWQQFGSDLNNIWTWLGATEE-ELERLRRLELSTDIQSIELQIKKLKLIEKFISAPPL
LLL-LIHGIHSFNRHLLSTSED--RQNRGQYE-QNAVREAGVTRTIRQVIRNEIMQGLDF
HEMSHGLLLMLENIDRRKNEIV-P-IDSHLDAEILQDQHKQLTQIRQELLESQLKVASLQ
DMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVGRHLKELEKLLDMSS-SQQDLSSW
SSAD--ELDTSGS-LSPTSGRSTPNR-QRTPRGKCSLSQPGPSVNSPHSRSIKGGSDSSL
SEPQPARSGRGFLYRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML
RYTNGPPPL---------------------------------------------------
-

-------MASGPAIPSEDE-QV-SLGIDDLQI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSTISDLFADIKKGHVLLDLLEVLSGQQLPRDKGFNPFQSRINIEHA
LTFLKNRS------IKLINIHVADIIEGNPSIILGLIWTIILHFHIQ----ELAQTLSCD
SNQ-----PFLDSVSAV-D--SSPTSSPPAKKYAS--VQSKWQMSAKKALLLWAQKQCGT
-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXVDVVDPDEKSIMTYVAQFLQYSKDAFRTGMPQE--KMKEAM--------VWL
AQQEQKLQDMLKDSENKTYSTKYEH----LLSFLNSFDEGKKPFLSILSIKTNLDALNGD
QLQLRKAWDRLNSKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXNLMDKFDYHLNTLRAFENEKEKHLPLVPPKKLEEME-RRI-YIISEKKFFP
LLEFHYYKYLVLGLLDEVKSKLDVWSIKYGSQESVESLLEDWHKFIEEKRFLTQLEASFQ
ECKES---WEN------LTGEYETIRKQYEMMEYKFCTYKKSIYNVKSTLQKVLECWATY
VKNLHFLKACFENTRKEQIKE-----VPFETLCQWNLDHAALNEVGNFLIDVSNDEIGLS
ITKELRRLNKRWRKFITKTQL----DM-N-LPQDHSKFDSSGN----------N-ELSNQ
EQATAEFFTNITGEHPENHNQ--NVK----------------------------------
--------ADEKPEKENEECTGQLNMAEEVEKLSKQ------VEIWEAETKSVLDLLLYE
DEVD--PSVEESLQHLIAKGSMYEELVSRTEDTLQMDIQNVSSQES---LQHILTAGLQA
KTQE-VKDKVQINVVKLLTVLKNSTEA-SPNLDIRVKVEESQTELESSMNRAEHLLDQRE
CQSDLISKYKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--ACFSQEGSLN
QLEQHMAV-RDLCDE-LT--SPE-QQEVRRVLRDFEQXXXXXXXXXXXXXXXX-----XX
XXX-XX--XXXXGSTGTSEKEGKNGHSEVPAAELDPQPQTEK---A-LKS-KDFSLESKF
PQEESIMKDEMDQNAF---IQSLLDRYDTHRESLSLHLTNNECRVTSDFLCGKEWSSAFL
QDKLNDLQ-ILKHETDACWEEFETTSLKLEEFVSDTDKQ-YFIKTRETLKEKENELQNNL
LSRMESLKAVQHIILPLEKEYRLICDSD-LLLQEVGIQEFQLTNVDGLYQNLRXXXXXXX
XXX---------------------------------------------------------
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----------------------------------XXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-------XXXXXXXEKDKLLE--------TISTSNELLKNIQDVHTQISKIGLKDPSVPA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-TE-----EELLMESTQLIDRYQALLTQFCESEEEVKLPSAEDQSFSDLAHDVIQWI
TEIKEALMVLNSSEGRMPLEERIQKIKEIILLKPEGDAKIQAIVSQAE------ESTVPS
V--PKALAEIQDQWDSTVHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLPEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
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-----------------XXXX--NSAVEMILSKQLSLDVQEGLKNTEDEQKVNEVQNQPL
ELDIMLRNEQLKEIEKLYMQLEAKKAAIETLKH----SETEASALVLHNARDSVQLLDNL
LQTLTTLKNNRESQYCRLQDFQEHLSANESSMKALLVEKEGLKV-XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-----XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX-X
XX----XXXXXXXXXXXXXXXXXXXXXXXXXQVLKLKEVFDCIGLKWDVPQLD---QLQI
QVYGGKKAVVNRIKHLHTFVAEYDKYQVSLGKLRAVDLRNRQRAEVFLETLNTSP-ESSL
SDVQILNQRLEKIMCLYQKVIKKLCDNKAFDDSFKEKEMLQMMQYIKENEELHRVL-QNV
MPECHPKEVDEKNFQDKLENSLYVLSQINSQLQQPLFINLKIEHLEKEMDNCGEFEEKVQ
AEMCCIKAMTVTEKQSE-ESAS-AASDVEVKLCDLEDLHRHLNTSLNLRTNVLNDAYENM
VCYDAAVAKMMGIISALEATL--ARVDPDHPEGSLEKASCQ-QRELESTMADIQDLSEKL
GAVCSPEAKLQLQQTLQELSSKNSALREAIQVKEAEIE--RCL------QDSKRNINLKE
KMYANLSKMETALAQSMSVFPRSYKEALEHLEESKXLVSNL--TKEELMKLRQLRDW--R
ESTESDNPCVMA----LCEKWLCLLAAAREWEMWCEELKQEWKFINEEIEREAIILDNLQ
EELPEISKTKEVATTEELSELQGCLCQYEENVETQQLLLTLLLQRIKSIHNIPENLGTLE
T-VPSFKEIASMQERGHRLLQKTRNNKESIQNEIQERHSFTKEIITLKKLFQQTATSLQN
SQLQDHSEKKDPLEELQSVFKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDLDEKISNEVLKTSPSFAMSRKISEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDAEVHDIVEEDPGQAQEWMDNLMIPFQRYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWIENTSRLLANPADYDSSKMLSQHASTLQMA-LEDSEQKHNLLHAVYTD
LEDLSIIFETDDLAQ-SIQNLSHEVATLQQKIMENLPRIQRMADDVVAIETEVKSMEKRV
SKIKAILL-SKEIFDFPPEEHLKHGE----------------------------------
-VILNTLRPMKKTIAEIMSYQVELRLPQMGMKPPPVFQRTTQLLQDIKLLENVTQEQNEL
LKI-FIKQMSEYDEEIENLNEILNNYSAQVSCEHMLPDQVANLPQLQG-EIEGLEKQILT
LNQKKEDLLPDLKAALLKLHQHLQQEHPEPE--KEIPSVGTT-EEVGITER-EVPERQL-
--KRKGSMSVLPAVKEELEEGSLKSEXXXXXXXXXXXX--XXXXXXXXXXX-XXXXX-XX
XXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXGATPPTT
ASALGFSDEQG-AFEATV--ERPGPEPEEILHVCKIQVAELELWLHQANVAFEPETLNAD
MQQEVEQQLVGCQAMLTEIEHKVSSLLENCKDQGSGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--HSAILKKP--A--EHPKVLQSDNLSEFESFITERPQFSKQKDFQ
QQQ--XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX---------XX-X
XXXXXXXXXXXXXXXXXX-XXXXXXX-----X-XXXXXXXXXXXXX-XXXXXXVATNMSI
LPSVSVYNFRYPTTEELKTYTTQLEDLRQEAINIQTQXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXELQQTPRLVREDMCAQQARW----ETLALELKKLFLALTDRKEDLLKAMTWPG
WNTSQFRECFEMLHDYLKGTQLVAACQSRALKAGLDYRRSFQHEVKRLYEQLSKNKMSLQ
QSLNEISGQSIDEQLQKADAHTMELQHLESQVSKLREEGKRLHFPYVLLQDVYKLEDMLD
SMWGILRARYSEFSSPFISESQQEALFQGMVELVNIGKEKLACDHLKQAKSKVALQSLLQ
NHKLFFQKLIADMWLIQTFSNKMLPSLLQKKETSWAEQTKEVQSLEEKARQYGIKLQSLL
QKWEEFDENYATLEKDLEILVSTLPSVSLVEETEDRLMERIAFYQQLKRNVDEKHARLCQ
TLNEGKQLVASVSCPELEAQTAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNK
DSDQLTKWLDSSQQTLNYWKEQSLNVTQDLDTVRSNINKFFEFSKELDEKTSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLH Q LQMEKLPSRNAITEMISW
MNNVEHQTTDEDSEHLLSSASQVKNLLQKYREFRMEMNYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAERLGEMNRQWHRIQGMLNRKIQHLEQLLESITENENKIEILNNFLEAQEE
RLKTLQMPGSVISVQKMLLDCQDIENQLAVKSKALEELRQGDLTLES-GTLPLLEDTASR
IEELLHKRDSVINQVSELKPSMQSLLQEWKTYDKLRDEMNVMTIQLCYCVEQSKPVV--L
TLEALQSQVQSLQSLQDEAESSEGSWEKLQEVTRKLKDYC-PSVAEIIKEKCQDTY--TR
WTQVNQ---DIADQLQKAQSLLQLWKAYDSVHAEAVARLEQQEAKYKQLANINMSGNNLV
EILTSAVQDLK-ELQHDVQKTKAAFLQNSELLDRLPT-PAEGSTHMPICDQQHCLQRASY
LEKMLLMKANEFEFVLSEFKDFGDQLESLKDVI-IHEEENLNKLYQQEK--EENPDLLQT
HVLALTAQAPDIEHLNEVSLKLPLSDIALKTLQNMNRQWIRATATAL-EHCSELQGIKLN
-EK-FVYCLEKWVQLLEKIEKALQVNLADSFPALLEQQKTFGMLEAEVSISQSIADFYVT
HSLQLLDTTEIENRPEFVSNVLRLKDQWQAAAQGIGQRKSNIDALVKQWQSFT-SPEA-D
LLRFLTNTRHLLSTVRGQDCYSLSQARNLLQELKDKEIHFQRWQTTYALTLEAGNQLQN-
-TTNLETKESIGLRIHQLQDNWKDTKLQVELLKKHLQNIL-ETWEQCEKKIKELKSRLRL
LTAQSKEPLPELHEDLHKEKELIKELENSLSNWHQNLQELPTVKADFTQHILAEDVMILK
EQIELLRRQWEDLCLRVAVRKQEVEDKLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMAEELMKASSKARATEIDDKLNKVNDRWQHLFDVIESR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDSLQKRVTAILRRLRHFISQREEFEGTRDSIVVWLTEMDLQLTNVEH
FSESDADDKMRQLNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX----
XXXXXXXX----XXXXXXX----XXXXXXXX--XXXXXXXXXXXXXXXXXXXX-XXXX--
-----XXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------
------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXXX---XXXXXXXXXX-XX-XXXXX----XX--XXAFERWEPLPTQELHNKLRMKQN
L---EQLNSDLSNIATWLEETEA-ELEALKTEEPPSDVQEMGLRVKRLKELLNAFDTYKA
SVVSVNERSEEFAPLESAESRE--LLGRVGQLCVRWDAAQGALESWRESLR QSL MQCQDF
HQLSQNLLLWLAHAESQRQKAH-IAADPQADPQTLLRCREDLEQLEKELVEWQPQVNALQ
EISNSLLVKGHEEDYIEAEEKVHVIEKKLKQLLEQVSQDLKSLQGSQSPHL-SLPG----
--ID--KGD-TGE-KPPAAPLPTPQA-KVKA----QRTRKGKNKSD-------SRVPHSA
VSG-SSQPQRSFLSRVIRAALPLQLLLLLLLFLACLLPSSEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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---------------------------------------------------------LEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
S-VPAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIMALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESKTSQLNKATVKME
EYNDLLKSTEAWIENTGHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDAVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
AATLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETYKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSELESIVTERPLFSRQKDFQ
QQQVILAPNKVPRL----------------------------------------------
---------QSLS---PP-TGQQWEITRQISLHHELIHQKIKLPTPSQLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAALYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHHVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRGSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESNEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNVVQGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTVDISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISTITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNESSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TNPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPMASVPAPRAKVKWV----VPV--EPPNWL-------STSSVGR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAV--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPKKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDSSGN----------I-L-SKE
EKATVEFSTDTSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSADV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEMKRLLKDYEQKIERLLKCASEIRMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATMKFNLASEL
KPPQKESIM---EKDYSASVNSLLERYDTYRDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKKETDVCWKEFEIISLKLENHVSDIKKP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEINLMKDKAKHLDKCLKMLDMSFKDAELGEDTSCENLLGALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELRKNIQDVQSQISKIGLRDPTVPA
VKHRKKSLIRLDKVLDEYEEEKIHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENAKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQRFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQGSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVNQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQVTSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEVIMSKQLSLNAQESMKNTDDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVV
EYDEFTTLMNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFREQVW
TEMCSIKAVTAIDKQRE-EEKSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESPEMPLRK-QEELESTIAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKETFKARKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSSLPLSYREALEHLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
S-VPAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIERAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESKTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDAVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RERLPAVAS-EEGGVAER-DASEQKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
AATLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSELESIVTERPLFSRQKDFQ
QQ--QVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDT-AQESSA----------SNQ
ASSPEKDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLNKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAALYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISSQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHHVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESNEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAIQGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAKMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTVDISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRTAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISTITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TNPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLQEQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPTASLPAPRAKLRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLLTEDE-QA-SLGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIIDGNPSIILGLIWTIILHFHIE----ELARTLSCN
YNQ-----PSPDRVSVV-D--SSPTSSPPAKKCSK--VQERWQMSAKKALLLWAQEQCAX
-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXVDVVNPDEKSIMTYVAQFLQYSKNAPGTGNKAQG-KMKDAM--------AWL
TLQEKKLQKMLKDSESETYANKYGS----LLSFLESFNEEKTPFLDVLLIRRNPDELNED
QLQLKEAWDGLNYQINVWKTDLNHVLPSPLNEIEAWLQEIEELLDEDLPASQDYHEAMAL
IQEKMALFKSLMDKFDCHLNALLAFENRDEKHLPLVPPSKLEEMK-RRI-NNISGKKFIP
LLEFHYYKCSVLGLLDEAKSKLVAWNIKYGSKESVELLLEDWHKFIEEKEFLAQLETSFQ
KCEEI---HKD------LXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXRLLKA-FEETKKEQIKE-----VPSETLSQWNLEHTTLNEVGNFLIQASNDEVGSA
ISKDLRRLNKRWRKFITKTQVEMNLPL-I-KKQDEPFLDNSGN----------T-QLSKE
GKTTVDFSTDMSIGLPENHNQ--NIM----------------------------------
--------AGEEDEKENEEFIRQLKVAEEVEKLVGQ------VETWEAETTSVLDLLRHQ
DDVD--TSMEDPLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXX
XXXX-XXXXXXINMIKLVATLKNSTDV-SPDLDVRLKVEESQKEVESYISRAEQLLGQRE
SHSGLISQYKEALIIFNTKSLAKYLKAVEELKNNVTEDVRMSLEEKSRDVCARWESLHHE
MSLYIQQLKVDIEKGKLSDTIAKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIHMTL-----QP
MVG-GA--SKNKRTPDTSESGGRSALSQVPSAKSDHQPLAEK---A-MESIKDVSLESKL
KPQLEESVMEKHEKDHSASVNSLLERYVTHRETLERHLQNNIARITSDFPGDKERSSVCL
QDQLTDLQ-VLKNETDACWKEFEITSLKLEELESDVKKP-SIVQARDRLKGTERELQMTL
NTRMESLETALQIVLPVEKESLLLCGSD-LLPREMAIQEFHLTDADDIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQMEICNNL-EQPGNFALKELH
PLDLQATQSIILKHRTQLEEMNHRVQRSKDALKALEEFLASLRTAQCSVGLL-TDLSASD
SQVLPENTLTVENKEGEIYQMKDKARHLDERLKVLGISITDAEQGEDTSCEKLLAALSEN
SSETLSSGGQEELTEEDKLLET-------CIFKNNELLKNIQDVHNQISKIGLKDPTVPA
IKQRKKSLIRLDKDLDECEEEKKQLQEMANSLPQFKDGREKVLSQKCQDTALLWENTKAS
VAECLDQCERVLELLKQYQTFKNVLTTLIQKEENVISLQASYMGKENLKKRIAEIEVVKE
EFNEHLEIVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDNLFNLKNGIDEWTEKALQKIELHQLTEEEREKLREELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIKMNLKECFESSETKKSVEQKLQKLTXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXLQDDHSNLSKWLTNQEEKWKEMEGSGEKTELFCQALARKREQFESMAQLSNSVKE
YGF-TEE----EEIVMESTRLTDRYQALLRQICEIDEEDKLPPAEAQPLHDLAHDVIHWI
TGIKESLMVLNSSEGRMPLEERIQKIKEIILLKPEGDAKIQTIMNQAE------SSKAPL
V--PKSFTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-QQEVG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPNFSEEPWLEIKQ
LHESLLQQLQDSVQKLEGHVREHESYQVCVTDLNTELDNISKEFV-FPEEPVDPIAV-EK
L-QKLQELENSLHLQDGTLEKIIALAKSIKQNTSSVGQKI-IKDDIESLKC-KQKDLENR
LESAKQEMENCLNSIL-KSKCSTEK----KEKF-ALPDREGQVTSDGQESTQGSAAVEKL
EEDW--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------EINK--NSAVEMVLSKQLSLDVQESMKSTADEQKVKELQNQPL
ELDVMLRSEQLKEIEELYTQLEAKKAAIEPLEETKDLNKVETSALVPHRERHSVHHLDNL
LQALMTLKKNKESQYCLLEDFQKHLAAVESSMKALLTEKEILKV-GPLDSATYMDKIKKF
LASIEKEKVSLNKMKIERERLSNCLTDMDKKLLESQMKQLEHDWEQVEQLVQKKYSQEVV
GHDEFTFLMSKVQALEVSL-Q---QQQRCLQLRLNSP-EQEGNQSMVALATELQTLKHRF
SVLKGRAEFQMKRIWGEKEKKTLEGAMNNLQKQVEAL-EPLNVEVE-----NQIKKCETR
YRMKETILWVKNLLGDVVPTISLLPDDILSQIRKCKVVHDGILDKQRVVESLVEEVKGNI
PNLTAHESNDLNNLLQDLQNQYQVLVLKSTQRSQQLEFKLEERSKIFALIGKVQLLLQGN
ETLIIPKMETTS-TEAELEHQHGTLTTSQKELQEIESVISTHLQEQTDVCNDLSVFERLF
LDDQLKNLKARANRIQRFIQNKCDEVEHKINFYRECHEKTSVLQKEVDH--IQHNELL-L
NP----ELNQDVKEELYSLKDRLTSVQSGILQVLKLKEVFDCIGLNWDWSQLD---QLQT
QVLEKEKELEGKIKQLNTFVAEHGKYQASLGKVRAMDLQTKKRAAAVLTTPDTSP-GSRQ
LSAQILSQRIGKVVCLYHEVIKRLSESKAFDDSFKEKEIQQIKLHAEENEKLNEVL-QHI
VLESQPKEMDEKNFQDKLENFFHVLNQIKSQLQQPILINLKIEHIQNEKDNCEAFQEQVQ
AEMLSIKAVSV-FEEQREEDSS-KASDVEAKLREIEDLHMQLNASIDSRTNALNDAYENM
TRYNEAVSRAAGTITALEAIIASHQVDLSNPNESLEGPRWK-QEELGSTIADIQDLAENL
GTVCSPEAQRQLQCTLQELLSKNSAVREAAKVKEAEVE--RCL------ENYKCYQKIKE
KICSNLSQMETVLGQSMSPLPVSYKEALERLEQSKALVLNLVSTKEEFMKLRQVLRHLRP
MCTESDGVCLLRSMSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EEL-EISKTKEAVTTEELSELLDCLCQHEENAEKQQLLLALLLQRIKNMQNAPESLAAVE
T-VPASLEITSMQERCSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXELQNFLKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISSEVLKSSPSYAMSRKIDEINKGLHTVEQMLQQKSQNIEKAQEIQKKLWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYHDLLKSTEAWIENTSRLLADPADYDSSKTLSHHASTLQMA-LEDSEQKHNLLHSAFTD
LEDLSIIFETDDLAQ-SVQELSHQVAALQQKIMESLPQIQRMADDVVAIEMEVKSMEKRV
SKIKAILL-SEEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEILSYQVELRLPQTGMKTLPVFQRTNQLSQGVKLLENVTQEQNEL
LKI-VIKQTSECDEEIEKLKQILNNYSAEFSQEHMSPDHAASLPQXXX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX--XXX--XXXXXXXXX-XXXXXXXX-XXXXXXL-
--NRKGSMSFLPAVEEEAEESSLKSESGGEKAEPSSGS--PSFLWKHDKDM-EEDRA-SS
SSGTIVQE----AAGKISICDSSMAQILAPDSPNTE---QGPEFFLSPNPTEEGATPPVE
AEAAGFSDEQG-AFEATV--EKPSPEPAEVLHVCKTQVAKLELWLHQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--HSAILKKP--S--EHQKVLQADNLSEFESVVTERPPFSRQKDFQ
QQQ--ILELNPMEQKDFIKFIESS-AHKMWPQYCQHNKET-TETSSM---------XX-X
XXXXXXXXXXXXXXXXXX-XXXXXXX-----X-XXXXXXXXXXXXX-XXXXXXVATNTSI
LPSVSVHNFRYPTTEELKTYTTQLEDLRQEADNLQTQENVSEETYTNLDKKLFDLFLTLR
QCLGSMEEMLQTPGLFRGDVGAHQVHY----KTLALELKKLYLAMNDKKHDLLKAMSWPG
KNPSLFLDCFDNLQVYLEHTQATAASKSKSLKAGLDYNRSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIDEQLQKADVYAVELQNYESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
STWGILRTRYTELSSPFITESQQDALLQGMVELVNIGKEKLAHDHLHQTKSKNALQAQIQ
NHKLFFQKLVADMLWIQAYSNKMLPSLLQKKETFWAEQVKEVKLLEEKSQQCGMKLQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNRKIDHELHRLQTLLKHLL------SYNK
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINSFFEFSKELDEKSSLKTAVLST
GNQLLHLKEADTAALRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTADEGSEHSLSSASQVKSLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGKLNREIQHLEQLLESITENENKIQILNNWMEAQEE
RLNSLQKPESVISVQKMLLDCQDIENQLAIKSKALDELRESYLTLES-GTMPLLEDTASR
IDELFQKKASVIHQVGELKTSMQSVLQEWKIYDKLYDEVNMMTIRFGYCMEHSKPVV--L
SLEALRCQVQNLQSLQDEAESSEGSWKKLQEVIGKLKDYC-PTVAEIIQEKCQNTH--TX
XXXXXXXXIPLAEQLQRAQSLLQLWKACNSAHAEAAARLEQQEAKYQQLANINTSGNNLA
EILPPALRDIK-ELQHDVQKTKEAFLQNSTLLDRLPQ-STESNPHVLVSGQLHSLQRTSY
LEKMLLLKTNEFEFVLSQFKDFGDQLESLKGLI-VHEEENLDHLYQQEK--EGNPDLFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FIYCCEKWVQLLEKIEEMLKVNIADSLPALLEQQRTYEMLEAEVSINQTIADSYVI
QSLQLLDTAEIEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNKEIHFQRWQTTYALTLEAGEKLLN-
-TTNLETKESIGKRISQLQDNWKDTKLQLGETIKQFQSIA-ETWDQCEKKIKELKNRLQV
LKAQSKDPLPELHEDLHKEKELVKELEKSLAHWTQNLKELRTMKTDLTQHILVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDRLIKASNKTRAAEIDDKLHKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLEDYSRFEDWLK
SAERTAAYPNSSEVLYTVAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
RLKQMVHEGNQRWDNLQKRVTAILRRLRHFTKPKGEFEGTRESILVWLTXXXXXXXXXXX
XXXXXXXXXXXXXX-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLEDEKEASXXXXXXXX--XXXXXXXXXXXXXXXXX----
XXXXXXXX----XXX--XX----XXXXXXXX--XXXXXXXXXXXXXXXXXXXX-XXXX--
-----XXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXXX---XXXX-----------------------XXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDF
HQLSQNLLLWLASAESRRQEAH-V-ADPEADPQVLLAYREELMXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNPDS-SLPS----
--LD--EVD-AGQ-PLA-ASAPAPQA-ELGA----ERITKDKNRTD-------SRVPGPA
GPG-SSRPQRSFLWRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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------------------------------------GKEKLAPGPLQHAKSKVALEAQIR
DHKGFFQKLVADMLLIQTYSAKMFPSSLQKRERFWAEQVAEVKSLEEKACLHGTQLQSLL
QKWEEFDENYASLEKDLEVLVSSLPSVSLVEETEERLLERISLYQQIKRNIDGKHARLCQ
TLNDGKQLAASVSCPELEGQIMKLEEQWLSLNKKIDHELHRLQTLLKHLI------SYNR
DSEELTTWLGSSQQTLNYWKEQSLNVSQDLDTIRSNINKFFEFSKEVDEKSSLKSAVLST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITETISW
MNTVEPQA-GENSELSPRSSSEVKNLLMKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHQVHGTLNRKIQHVEQLLESITENENKIQNLKNWLEAQEE
RLKTLQNPESVISVEKLLLDCQDIENQLAVKSKALDELRQSSLTLEN-GVVPLLEDSASG
VDELLQKKGKVNSQVGQLKASMQSVLQEWKAYDKLYEETNVMTIRLAYCTEHSKPSV--L
SLEALSCQVQNLQALQDEAESSEGSWEKLREVIGRLKDSC-PSIAEIIEEKCQSAH--SR
WTQVNQ---DLADQLQEAQSRLQLWKASHTAHTEATAQLEQQETKFQQLTNINMSGSNLA
EILPLALQDLKVGLQHSVLKTKEAFLENSALLARLPQ-PEENSVPGLHSGQLHSLQTAAY
LEKMLLLKSNEFEIVLAQFKDFEDRLESLKDLI-MHEEENLDKLYHEEK--EENPDLFLN
HVLALTAQSPAIECLNEESLKLPLSDMAVKTLQDVNRQWIRATATAL-DHYSKLQGYGLN
-EK-FLHYCEEWIQLLEKIEDAVNVDIAQSLPALLEQQKTYEMLEAEVSVNQTIADAYVI
QSLQLLDTTEVEKRPEFVSEFSKLLDRWQNATQGIQQKKCDINRLVRQWQYFT-TSIE-D
LIRFLTSTSHLLSAVKGRDCYSLYQTRYLMHELKSKEIHFQRQRTTYVLALEAGEMLQN-
-TPNLETKELIDRRASELRDTWKDTELRLGEMIHQLQSTV-ETWDQAEKKIKELKSRLHV
LKAQNKEPLPELHEDLHKEKELMKELEKSLANWTQNLKELQTMKADLSRHILAEDVMVLQ
EQIEHLHRQWEDLCLRVAVRKQEIEDRLNSWVVFNEKNKDLCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINIFSDAR-LQLKQVGHQLMKASSKTRAAEIDDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYTRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTGILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAMLIEDELEELHRY
CQEVFGRVSRFHRRLTCHTPGLEDEKEASENETDMED--PREIQTDSWRKRRESEE----
PSSSQSLC----HLVSPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSACELDPFGCV--------SSTIARKSISEGHS------
------------WHIPDSPSCPKHRYKQMEGDRTAAPLPSDSSTPYKPAYVKLLLRQGT-
GDGKEG---LRGSKDSPQR-ED-EQLAPLTG-QQ--SGTFDRWELIQAQELHSKLRIKQN
V---QQLNSDISDITAWLEKTEE-ELKALKMAERPSSIQEMAVRVKRLQEILKAFDTYKA
LMVSVNKSSKESLPTESNESSE--LQSRLHQLSLRWEAVQGMMDSWRGDLRQSLMQCQDF
HQLSQDMLLWLASAESRRQRAH-V-TDPKADHQVLLEYQKELMQLEKELVDRQPQVSSLQ
QLSSSLLVKGHGEDYIEAEEKVHVIEKKLKQLREQVAQDLMSLQGSQNPDL-SLAS----
--FD--EVD-SGE-HPPAAYVPAPHTKVSTL----PFM--RTTLVS-------LKMPHLT
DPG-SSQPRRSFFSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----------------------TQDLEKSLANWTQPWRELHTAQADLSTHVLAEDALALQ
KQAEHLHRQWEDLCLRVAARKQEIEDRLNSWNVFSEKHKELCAWLVQMENKVLQTADISI
EEMIAKLQ-----------------------------------------------KDCME
EINLFSENK-LRLKQMGDQLIKASSATRATEVEDKLHKISDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFTFIQQLDRNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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----------HIPPSVITDLFTDIKKGHVLLDLLEVLSGQQLXXXXXXXXXXXXXXXXXX
XXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIE----ELAWILSCN
YNQ-----PSLDCVSVV-D--LTQTSGPPPKKRSK--AQARWKMSAKKALLLWAQEKCAT
-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXVDVINPDEKSIMTYVAQFLQYSKDLPVAGDEVQE-KVKDAT--------VWL
ISQEEKLHELQMESEKETYFKKSQG----MRAFLESFNEEKKAFLDVLSIKRNVAGLADD
QFRLRQAWDKLTNQINEWSAKLDQILPTPLDQIEVWLQEIEHLMAEDLPDSQDYSQAMIV
IKERINSFKSLMDDFDRHLNSLLTFENKDEQQMPMVPPDKLEEMK-RRF-HNIMGTNFIA
LLEFHYYLCSVLGLIEEVKSKLNLWNIKYGTQESVKLLLGDWHKFIEEKELLTQLESSFQ
KCETM---TKN------LAGDPQNISKQFKMVESQISMCRKCMYNIKSTLQKVLSSWATY
TENLHSLKTWLEESRKEHPKQ-----IPFETLASWNSVLSTVNEVGKFLIDVSNQQVGLS
INKELKRLNKRWAKFIKKTQFEMKLHF-T-QEQEQPSLDITGN----------TELPLEE
NLTSYGGSTDISTETLRKHIQ--HLK----------------------------------
--------TGKENEAVIKEFTELLQVLEEMEEFISQ------VATWETEIRPVLDFIKQQ
GYVE--ASMEESLQNLIARGSMYQEHVTRKENALQIIAQNISSKAL---LQHFHTSGLQT
QIKE-AKDKVQNNMAELDAVLQASYES-SLEMDVRAKFEKSQRELESDILKARQFLGQKW
SFGDLVSQKKDILAILNSKSLEKFLKAAEQLKNIVSPDEKLSLEEMSREFSKEWEGLHQE
VCLYIHRIKIEIEK-KVTENISKLEKQLNKEKKLLSKGKTKGLIEEHE--XXXXXXXXXX
XXXXXXXXXXXXXXX-XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XX
XXX-XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---X-XXXXXXXXXXXXX
XXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------NSISKQIELCN-L-EHLGSNALNKFN
PVDLHATQNIIAKYKMQFEEMNHKMLNTETALKALEDFLASLRKAKFSIQPE-TDFSTTD
VPVVQGNTWTIEDVKKKIPLMKDEARCLDQRMKMLDIRLKNAEQGEDTCCEKLIEVFSKM
IDETRGHNEHEDFTEQDQLLEV-------FIAKNNEILKNIKYVQDQINKIGLKDPTIPA
VKQRIKSLTKLEKDLDYYAEEIKYLRKMASSIPQLKDGKGEIPSQQCQETTCLWEDVKSS
VEECLEQCQRAMDLLKQYQNCKSILTSLIHKEESVISLQASYMGKENLKRRIAKXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXVIKSSLLNRIEKIKMHLMDKSNLSELNGSTAELKEDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQIL-QKHNMTLLE-QIGCLXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXKCKNFDDEFNNIQLSLKECFEPPDTKKSVEEKLQKLNDFL
TFEGRSKDIQQVETALNNVKRHLPKASVEQLSNWIMTQELELQKMKLTCQTQANGLHDCL
QQLLRLQDDYISLNKWLMNQEEKWKGMEE--NKHNIFFQALTRKRQLFESFAQLNNSLKK
FGL-IR-----EEIVIESTHLVEEYETFLAQVCEIG--NHQPPPEDQSFEDLVHDVFSWI
MGIKESLMVLNSTEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXX------XXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXHQEKIQLEEEKYLQSKDDLRLMLTELKK-KQESG
FALQNGLQEKKAQLKIYKKFLQKAEDLTSLLNELKTQGNYLLECTKNSKCSEEKWLEVKH
LHESLLHQLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX--------------------------------------------------------
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-----------------XXXX--NSGIEMLLSKQLFPEAQESMKNIEDEQRVNELQNQPL
ELDIISANEQLKEIEVLYGYLQAKKANTGMQESIILPGNTETSVLDVQNVQRSVDQLDRL
LQALVTLKEDKERQYSLIKDFQEHLLAVKSSMKALSMEKESIKA-ASLESVQHLKKLEKC
LESVHKEKDSLNKFKEQQVNLLSHLSDMDKKLAESQVKQLELCWEQVEQWIQKKYSQQGA
EWDELQCLMGKIRDLENSL-Q---EQQQQQQ-TLNSPSEQGENKGPVSLGTKLQATKENF
SLLKRRAEHEMKRIWGKKEKKTLENAINNLQEHLEAL-EPPTAEKD-----SQLKTCPTT
KKIQEAVLWVNNLLVGLEQTAALLPDNIVSQIRKHKTVYDEVLDKQPVIESLVEETKDVI
PDLNQCEATDLNTFSQELQSLNQALVSKCTEVSQQLESKLEERSTFFEKMGKVQRSLQGK
EVLIAPETKTIF-SKEDLDHQLVILKDSQKELQISEGVISTHLQEATGFSKSLNVFERVF
LDDQLRNLKNKARRTQRLVQNKYHDVRKKLDIETEFLEKTNILQQELND--IHNHELL-L
NE----KVNQGTKEEICELRDRTSVLQANLLQLMKCKEIFECLGLKWDSSTLD---KVQA
ELFKIKTELQQKAKQLERVVAENEMLQTSLNELKMVTLQIKKETAEIVNDPNFSP-ESSL
FSAQILSQRVEKATHLCQETIDLLNANETLKESFKQ-KIPQIKLLAEQNDKLHKSL-QNV
--KFPAPIFSEKDFTDQLEHALLVLTQANCLLQQPLQVGLEVKHIQEEKDNCEVLQQRVL
AELCHIKAITVKENPRQEDNPH-EPDLIKLNELDLIYT------GIALRXTILDEALKDM
EHYNEAVTRAVGIINSFEATVHSHKIALDDLGKFQQLTDGK-QEEFEALVVDLKNLTSKL
ENVTSPKAKVQLEHVLCELIKTNSLVKESTETKKADLE--XXX------XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIEREAIILDNLQ
EEFPESAKPKEAATNEELSEALECFCQYEENLEREQLLFTLLLHRIKSIMSVPESIETTE
S-VPVFQEIWSMQDRCSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXIRNEVLKSSPFYVMSKKIEEINQGLQNVEKMLQQKSKSIEEAQEIQKKMWD-LD
LWHSKLNELDSEVQDIVEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMA-LEDSEQKQNLLHSVYSD
LEEFSVIFETDDFAQ-LINHLSARVTTLQQKLMASLPQIQHMADEVVAIETEVKAIEKKV
SKIKAILF-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIKPMKKAIAKIESYQVVLRLPETGVKSLPVFERTNQLSQEVKMLEKLTYEQSEL
LKL-VMKQTGECDQEIENLKHQLKNYSTEFSSENISPDQATILPQVQS-ELDSMKEQILG
LNQKKEDLLMGLKTSVLALHQRLQQEKQELE--KE------T-EESGVAEG-DVSEWKX-
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX-XXXXX-XX
XXXXXXXE----PDGRISTYDGDNTQIFVPNLSKTG---QNLDTSPSHNQQEVGDAASIG
APAQNSGEQGS--LEETV--ASSRPESVEILHVCQKQVAELELWLDKTN---SEETLNPE
MQQMVEQELAGCQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--RSNTLKKP--S--EDQKVLPSNRSPVFESVSFESPLFGRPKGFQ
QQX--XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX---XXXXXX---------XX-L
ESHSKNGSPESFLPSHEQ-SEDKWQF-----L-LQELSKEKLP-PP-QPVDEQITANVNF
LPMVPVHTVSSPTIEELKTYTSQLEDISQEANALHTQETAGEPS--NLHKKLFDLLLSIS
QCLSIVEDMLQTSGLSREDAAVQQAHY----ETLSLELRKLHSAITSKKDDLLKLISHPG
KKSSVFFECFNNLQTRLDQTQVAAASRSQFMKSGIDHNSDYQXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDILD
GMWGFLRAKHAELSSPFINESQQEGLLRGLAELVNIGKEKLGQDQQRQAKSKASLQAQLQ
NHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XEWKEFDENYESLEKDLEFLGSSLPSMSLVEETEERLRERISFYQQIKRNIDEKQSKLYQ
TMSEGKHLATSVNCPELESQIAKLEEQWLALNKKVDHELHRLQTLLKHLV------SYNK
DSDELTKWLESAQQILNYWKEQSLNVSQDLDTIRNNINDFFXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXSLAQFEQKWATLITQLPDIQEKLHQLQMEKLPSRKAITEMINW
MDKIEQQTADEATVDSPRSVTQVKSLLQKYKESRMEMNYKQWIIDFVNQSLLQLSTSDVE
SKRYERTEFAEHLGEMNRQWHKLHGTLNRKIQHLEQLLESITESENKIQTLGSWMEAQGE
RLKTLQKPESVISVRKTLLDCQDLENHLAAKSRILDELKENYMALES-GPMPVLQDTISG
IDGLYQMRNNIVNQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXLLQDEAESSEGNWSKLQDAVRKLKDYC-PSATEIMEQKCQEAH--IR
WTRVNH---EIADQLQSAQSMLQLWESYTAAHAEATARLEQLEEKFKHILNVNMSGDNLS
EILIQALKDVK-NLQHDLENIKEIFLQNSAVIEPNLE-QAESSKMFFLIN--LSLQRISY
LQKMLLMKSNEFEHVLSQLKDFRNQLESLE----DNIKHSVESLELQGR--EDDPEFLLX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMLQAEISVNQPIADYFVI
QSLQLLDTPEIEKRTEFVVKLTMLKERWQDATRKAQQRRIAINERVKEWRRFS-ASLQ-N
VTHFLTDTDHFLSAVKSPDSYSFCQIRSLIHDLKXXXXXXXXXXXXXXXXXXXXXXXXX-
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XTWDQCEKQIKELESRLQN
LKAKIKDPLPEPYEELYKEKELIKELENSLANWAQNFKELDVMKADVTRYILVEDVMVLK
EQIDHLHRQWEELCLRVSLRKQEIEERLNSWIVFNEKNKDLCAWLVQMENKVLQTADISI
EEMIERLQ-----------------------------------------------KECME
EINLFSENK-LHLKQMGDQLIKASNKTRVAEIDDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RSWLARIESELSKPVVYDICDDEEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAEKTAAHPNSSEVLYTNAKEELKKFEAFQWQIHERLTQLELINKQYRRLARENRTDTAS
KLKKMVHEGNQRWDNLQRRVTAILRRLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-GFQQEITLNANKIDQLIVFGEQLIQKSEPMDAVLIEDELEELHRY
CQEVFGRVARFHRRLTSHNPGLEDEKEASENETDVED--SREIQSDSWHKKEVNEG----
PSSPPSLC----HLMPPPL----AHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSAVSDVEITENPEAYLKMTTKTLKASSGKSISEAHG------
------------WHTPDSPTHQKHRYKQTEVDRNVLPITSETSTSYNPEYVKQLIPPGM-
DSVDNG---REGPGMLNAS-EQ-KGLTD----TEQQAGVFDSWELIQAQDLRNKLRTKQN
LKQWQQLDSDINDVTLWLKGTEA-ELEELEMAKPAADIQETELRVKKLKDILKAFDNYKA
LVISINLSSKKVQQPDNTESKE--LQNRLRQLNLLWEKANHLLDSWRESLQHSLMQCQDF
HQLSQSLLLWLASAENRRCKAQ-V-VDPNADPHAILESQKELMQLEKELLEHQLQVSSLQ
EISKYLLAKGNRENYIEANEKVHVIGKKLNQLLDQVSQDLESLQGSQXXXX-XXXX----
--XX--XXX-XXX-XXXXXXXXXXXX-XIEA----ERITEEESKKN-------SRVEHLS
D----SSGPRSFLYRVFRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----------------------MQELEKSLANWTQNLKELHTMKADLAVHVLAEDAMALR
EQIEHLHRQWEDLCLRVAVRKQEIEDRLNSWSVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASGTARAAEISDKLHKINERWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDGNMSSL
RTWLARIESELSKPVVYEVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFSICDVLLHD
SDACASETECDSIQQTTRSLDRRWRN----------------------------------
------------------------------------------------------------
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-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQDVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPKKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDSSGN----------I-L-SKE
EKATVEFSTDTSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVG--TSMEESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATMKFNLASEL
KPPQTGSIM---EKDYSASVNSLLERYDTYRDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKKETDVCWKEFEIISLKLENHVSDIKKP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLGALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELRKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKIHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENAKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVNQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMIMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLQNIGYSAQPLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVV
EYDEFTALMNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDGGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRINRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKVKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKVPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRE-EEKSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESLEMPLRK-QEELESTIAHIQDLTGKL
GMISSPEAKLQLQCTLQELVSKNSAMKETFKAWKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSLLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
S-VPAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENASHLVANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EEGGVAER-DASERKL-
--SRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAPILTPDSLNTE---QGPERSLRPNQTEEGTTPPIE
ATTLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSALESIVTERPLFSRQKDFQ
QQ--QVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDT-AQESSA----------SSQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTIQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHSQAAAVYRSKCLKAGVDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLTHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQGK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLMKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNASSKEFLQTESPESTE--LQSRLHQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRAKFRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWGIDDLHI-----SLQ---------AEQEDIQKKTF
TCWINSQLARHISPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------V SL-------ILTGN----FGPI--------IE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQVS AKKALLLWAQQQCAT
-YES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAHGTGEEAQG-KVKNAM--------VWL
TLQKEKLQKLLKDSENDTYFQKYNS----LLSFMESFNEEKRSFLDVLLIKRNLDELDKD
QLQLGEAWDGLNHQINAWTVKLNCALPPPLHQTEAWLQEVEGLMDEDLSTSQDYSQDMTL
IQEKMTLFKSLMDRFEYHSNNLLTFENRDENHLPLVPPDKLEEMK-RRI-NNILEKKFIL
LLEFHYYKSLVLGLLDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKGFLAQLDTSFQ
KCEEI---YKN------LAGECQNISKQYMVMKSDVCMYRKNIYNVKSTLQKVLAYWATY
VENLRLIRACFEEIKKEEIKE-----VPFETLAQWNLEHGTLNEAGNFLIEVSNDVVGSS
ISKELRRLNKRWRKFVSKTQLEMNLPL-I-KKQDQPTFDNSGN----------I-QLSKE
EKATVEFSTDLSIEPPENCNQ--NIK----------------------------------
--------AGEEHEKENEESTGQLKVAKDVEKVIGQ------VEIWEAETKSVLDLLRDQ
DVVN--TSVEESLKHLIAKGSMYEELMVRTEDMLHMDIQNISSQES---FQHDLTTGLQA
KIQA-AKEKVQINVVKLIAALKSSTDV-SPELDVRLKMEESQKELESYMMRAQQLLGQRE
SPGGLISKYKEALIICNTKSLAKYLKAVEELKNNVTEDIKMSLEEKRRDICATWESLHHE
LSLYVQQLKIDIEKGKLSDNISKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHTTL-----QA
TAG-GT--SRSEGTITTSENRGGDSHSEVLFAKSDNQPSAEK---A-MEPVMNFSLASEL
KPPQEES---IMEKDHSASINSLLERYDTYRDNLEHHLQNNEFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VLKNETDACWKEFEIISLKLENLANDIKKP-FIVKERDRLKERERELQMTL
NTRMQSLETALQLVLPVEKASLLLCGSD-LLLHKMAIQEFGLINADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-KKPGNFVLKELH
PCDLHAMQNIILKYKTQFEEMNCRLQRSEDTLRALEGFLESLKTAKLSAEPV-IDLSASD
TQVAQENTLTVKNTEGDIHLMKDKAKHLDKRLKMLDMSFKDAEQGEDTSCENLVDALSVK
LSETHGYGVQEEFTEENTLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKDLDEYEAEKKHLQEMANSLPHCKDGREKAVSQQCQNTILLWENTKAF
ITECLEQCGRVLELLKQYQNFKGILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMKTFEEPPFEKESNIIVDRWLDINEKTEDYYESLG
RALALWDKLFNLKNVIDEWTENALQKMELHQLTEEDRERLKEELQVHQQKASEFSQRVAE
IQFLLQSSEIPLELQVMESSILSKIEHVQKCLTGESNNYALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLRDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKRSVEQKLQKLSDFL
TLEGRNSKIQQVDSVLKHVKKHLPKAHVKELSSWLVGQEFELEKMESICQARAKELEDYL
EHLLRLQDEHRNLSKWLTNQEEKWKGMEEPGEKTELFCHALARKREQFESVAQLNSSLKE
YGF-TEE----EEIIMQSTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLQERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFITFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKY-KQKDLENR
LESAKQEMEYCLNSIL-KSKCSSEK----KEKF-TLPGREKQATSDVRESTQGSAAMEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVETVMSKQLSLNVQETMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEI----------------------------------------------
-------------KFYLY----------------------SFSR-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
EYGEFTSLMNKIRDTEISL-Q---QQQQHLQLRLKSPEEQAGNQSMIALTTDLQAAKHGF
SILKGQAEFQMKRIWGEKEKKILEDGINNLKKQWETL-EPLNLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILDRQQAVESLAEEVKDKV
PSLTTCEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMAQES
ETLITPKVETTA-TEAELKHHHVTLKASQKELQEIDNVISIYLQELTNIYEELNVFERLF
LDDQLKNLKNRTNRTQRFIQNKCNEVEHKINFCREFHEKTLVLQEEVDS--IQRNELL-L
NQ----EVNTGVKEAICNLKDRLTAIRCSILQVLKLKKVFDFIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSEMRAIDLQIKKMTEVVLNALDSSP-ESRL
LNAQILSQRIEKAKCLCEEIIKKLNDNKTFDDSFKEKEILQIKLNAEENDKLYRVL-QNM
VLDLPPKEMAEKNFQDKLETSFHVLNQIKSQLQQPLLINLEIKHIQNEKDNCKGFQEQVW
AEVCSIRAVTAIEKQRE-RKSS-RTMERITS-----------------------------
--------------------------------------------------------SKKL
GMISQPEAKLQLQCTLQELVSKNSAMKEAVKVQETEAKKVRYL------ENYKCCRKIEE
DIYTNLSKIETVLGQSMSSLPLSYREALEHLEKSKALVSNLISTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPEGSGAVE
T-VSAFQEITSMQERCNQLLQKAQKNKALVQTEIQERHSFTKEIIALKNLFQHTTTSFQN
MAFQDHPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKV-------IIMFVLLLLFMEPNDYFPSSQQRRKNVLKQTLRTECFTFEIFLCPA
KFRFESNLLSLSSSKRHPTKFG--------------------------TASLSQATVKME
EYSDLLKSTEAWIENTSRLLANPADYDSSKTLSHHASTLQVSVLRFSNDRHNLLHSILMD
LEDLSII---------SIQELSDQVT-----IQQMADVSWHHKDDVVAIEFEVKSMEKRV
SKIKTILL-SKEILDFSPEEHLKHGE----------------------------------
-VILENICPMKKTIAEIVSYQVGLRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNHSAQFSFEHMSPDQAAKLPQLQE-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEKVE--RDVLPAVAS-EEGRVAER-DASEWKL-
--NRRGSMSYLAAVEEEAEESSVKSENGDEKAEPPPQS--WSSFWKHDKDV-EEGRA-SS
SSGTIVQE----AYGKISTCDNSMAQILAPDSPNTE---QGSECSLRTNQTEEGTTPPIK
VATLDSSDTQG-GLEHRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLEACKDQGLGDNGATQYEAEALSLKLRTVKCNLE
KVQMMLQEKHSEDQ--HPTILKNR--SEPEHQKVHQPVNLSELESTVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKAT-TQESSA----------SNQ
ASSPENDVPHLILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMSI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEETYVNLEKKLFELFLTLS
QCLSSVEEMLQMAGLYREDGSAQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWPG
RNTNLLLECFDNLQVCLEHTQAAAASRSKSLKAGLDYNRSFQNEIKRLYDHLIKSKMSLQ
QSLNEISGQSVAEQLQKADAHTVELENSESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGILRAR-----GPFVTESQQDALLQGVVELVKIGKEKLAHDPFKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILLSTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVVSVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLVKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSMHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQVAIKSKALDELKQSYLTLES-GGMPVLEDTASR
IDGLFQKRSSVITQVNQLKISMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQDTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSSAHAEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEDFLQNSTVLDRLPQ-PAESSTHMLLLGPLYSLQRAAY
LEKILLVKANEFE-------DFGDRLESLKGLL-MHEEENLDRL-HQQE--KENPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSKLQGIGLN
-EK-FLYCCEKWTQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSFVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKSDIDGLVRQWQDFT-TSVE-D
LLRFLTDTSHLLSAVKGQEHFSLYQTRSLIHELKNKKIHFQRWRTTYALTLEAGEKLLL-
-TTDLETKESMGRRISQLQDNWNDTEPPLAEMIQQFQSTV-ETWDQCEKKIKELKSRLRV
LKAQSEDPLPELHEDLHNEKELIKELEKSLASWTQNLKELQTMKADLTRHVPVEDVMVLK
EQIEHLHRQWEDLCFRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNQSRAAEIDDKLNKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVSPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQTEGDGNVPPVPAESSTPYNPPYGKPLLPPGT-
DGGKED---PRVLNGSPQP-GD-GRLAGITA-QQ--SGAFDRWELIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTKA-ELEMLKTAKPPSDIQEIELRVKRLKEILKAFDTYKA
LVVSVNMSSKEFLQTESAESTE--LQSRLHQLSLLWEATQGMVDSCRGGLRQSLMQCQDF
HHLSQNLLLWLANAENRRQKAH-V-AHPKADPQALLECQRELMQLEKELVECQPQVDLLQ
EISDSLLIKGHGEEYIEAEEKVHVIEKKLEQLREQVSQDLMSLQGTQNPDS-PLPG----
--FD--EVD-SGD-QPLSASMPAPRA-KFRG----KRTTEGEE------------ETESR
VTG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPAEDE-QI-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWVNSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNQS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCS
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKQRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKRDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKELLARLDTSFQ
KCGEV---YKN------LAGECQNISKQYMMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEEIKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPL-MIKKQDQPTFDNSGN----------I-LS-KE
EKATVEFSTDMSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIAKGSMYDELMARTEDTLRMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLMKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATVKFNLASEL
KPPQKESIM---EKDYCASVNSLLERYETYKDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENHVSDIKKP-FIVKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSN-LPLHKMAVQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLTSLRTAKLSAEPF-LDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLDALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELHKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKKHLQGMAYSLPHFKDGREKTVNQQCQNTVLLWENTKAL
VTECLEQCERVLELLKQYQNFKNILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYHENLG
RALALWDKLFNLKNVIDEGMEKALQKMELQQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQELELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMANQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEN
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPRREKQATSDMQESTQESAVAEKL
EEDWEINKSFVENV----------------------------------------------
------------------------------------------------------------
----M---------------------------AVSKNCNHSLYVFESIA-----------
------------KNFLSDEMQ--DSAVEMIMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDSL
LQALITLKKNKESQYCLLRDFQEHLAAVESSEKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVL
EYDEFTTLVNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLSELIPSISLLPDDILSQIRKCKVTHDCILARQQSVEALAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTRRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVGTAA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLLQNKCNEVEHKVKFCREFHEKTSVLQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYFGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSRMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLAIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQREEENSS-EVSDVETKLREFEDLQMQLNTSIDLRTNVLNDAYEDL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESLEMPLRK-QEELESTIAHIQYLTEKL
GMISSPEAKLQLQCTLQELVSKNSAVKEAFKAWKNEAE--RCL------ENYKCYRKLEE
DIYSNLSKMETVLGQSMSSLPLSYREALERLEQSKDLMSNLTSAKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPETSGAVE
T-VPAFQEITSMQERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQAHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPAQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHSLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDKEIENLKQILNSYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEEVE--RDMLPAVAS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSMKSE--------------------HDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSPRPNQTEEGTTPSIE
AANLDSCDAQE-GLEPRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKSSEP--EHPKALQPVNLSELESIVTERPLFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHGEDT-AQES---------------
------------------------------------------------------------
-------SARYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREYGSGRQVHC----ETLALELKKLYLALSDKKGDLLKAITWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKALKAGLDYNCSYQK-----------------
-----------------ADGYTVELENAESRVVKLRDEGERLYLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQLE
NHKIFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELESQIAKLEEQWLSLNKKIDHELHRLQALLKHLLRSAFLGVDCR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVVST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASQ
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYRMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFE----------------------------------------------N
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIKEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISGFSKLTDQWQNAVQGVRQRKGDIDGLKTHVVRCGGASLKKQ
DLRYSLHT-----------AYGVAL-LCRSSHGANKEIHFQRWRTTYALTLEAGKKLLF-
-TTDLETKESVGRRISKLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKEL--------------------------------------
--------------IKVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQKRAVGREKVPERWEWETIVSGHGTEGSCFLSIRKFGQGRGFMFWCLCQDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRTVTYRRT
YKVNKELGGDTLNNLRCPIIYPHGLVQCIRLGEPLILKRVKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRF---ERQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQE-----------------GLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLV--AP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSGKSISDGHS-----------------------------
------------WHVPDSPSCPKHHYKQMEGDRNVPPVPPASSTPYKPPYVSLSSTGST-
ATY--I---CKRP-----------------------FGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLHQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPQALLECQRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPAP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRA-KFLY----TAVQSSENYRR-------RGGDREQ
GPW-QHTATALLPLEGDPGSPASAAAAPAAAAPGLPSALLRRRLQLHSGKQLCPVFLPHA
EVHQRATPH--IEDATPPA-----------------------------------------
-

-------MASSPELPTEDE-QI-SWGIDDLHI-----SF--------------------L
NDYFSCDLLQHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCS
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQVS AKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKQRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFTESFNEEKKSFLDVLSIKRDPDELDKN
HLQLREAWDGLNHQINAWKIKLNYALPPPLHQAEAWLQEVEELMDEDLSASQDHSQAMTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
HLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHVILIKNCFL-----RLL
FC--F---VDI------VAGECQNISKQYMMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEEIKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSSDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIAKGSMYDELMARTEDTLQMDIQNISSQES---FEHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKSKEALIICNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVERLLKDYEQKIERLLKCASEIHTAL-----QP
AAG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-TEATMKFNLASEL
KPPQKESIM---EKDYSASVNSLLERYDTYKDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENHVSDIKKP-YIVKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRIAKLSAEPF-VDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLDALSVK
LPETHGYGVQEELTEENRLLEA-------CIFKNNELRKNIQDVQSQINKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENTKAL
VTECLEQCERVLELLKQYQNFKNILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPLLKR----------------EDYYENLG
RALALWDKLFNLKNVIDEGMEKALQKMELHQLTEEDREKLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHSLSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQELELEKMESICQARAKELEDSL
QQLLRLQDDYRNLSKWMANQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCITDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMIMSKQLSLDAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDSL
LQALITLKKNKESQYCLLRDFQKHLAAVESSVKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVL
EYDEFTTLVNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTRRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDGGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYFGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRE-EENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNSDESLEMPLRK-QEELESTIAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKARKNEAE--RCL------ENYKCYRKLEE
DICSNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLKL
RCTENDGICLLKIVSALWEKWLSLLEAAQEWEMWCEELKQDWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMQERCSN------------------------------------------
------------------ILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPAQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHSLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
S------------IDYYLKYFL--------------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEEVE--RDRLPAVAS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPSIE
AANLDSCDAQG-GLEHRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSELESIVTERPLFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-AQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHKLSSKIKLPLL-QLVEPQVSLHLHG
VNSLEFF-----------TWLTHFLDLG--------NENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYTEYGSGRQVHC----ETLALELKKLYLALSDKKGDLLKAITWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKALKAGLDYNRSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLYLPYVLLQEVYKLEDVLD
SMWGMLRARYTELGSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVVLQAQLE
NHKIFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RMKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESREGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPESFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIKEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSCVT
QSLQLLDTAEIENRPEFISEFSKLTDRWQNAVRGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTLEAGKKLLF-
-TTDLETKESVGRRISKLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WRVPDSPSCPKHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PQVLNGSPQQ-ED-GRLAGITG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKVH-V-TDPKADPQALLECRQELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPAP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRAKFRAA----RTT--EG-----------EEETESR
VPG-STPPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSSALPTEDG-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVISDLFADIKKGHVLLDLLEVLAGQQLPRDKGSNTFQCRINIEHA
LTFLKKRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----ELARNLSCD
YNQ-----PSPEVATVA-D--SSPTSSPPAKKCSKAQAQARWQL SAKKALLQWAQKQCAA
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMDSVRHRSNKENLKEAFRIAEHELQI
PKLLEPEGRD------RNPTSLLSHFAVYSNDQKKPDQREDA-GFRDS----------WL
--------------KHNLY----------LLSFMESLNKEKEPFVDVLSLKGNMNELNED
QLRLRQGWAGLMHQIAEWKAQLDDALPSPLKETEAWLKDVEELVEEGPPTSQNYSEVATL
IQGKMSLFKSLMGSSDYHSNVLLAFENQDEDHLPVVPPDKLEEMK-RRI-NNILGRKFIP
LLEFHDSKCSVLALLDEAKAKLDVWNVPYGSKESVEVLLEDWRKFIEEKKFLAQLDTSFQ
KCEEM---FKN------LAGECESVEEEFVTLEKDVHECRQRIHNTKATLQRVLECWATY
EEDLQLLKTSFEATKKEQIKE-----VPFETLSQWNAKYTSLNEVGSFLTEVSNGEVGSS
ISKELRRLNKRWRKFITKTPLELKLPV-T-KIQDQPPGDSSGT----------I-L-SKE
-------SATMPAELPESPGE--VIQ----------------------------------
--------AVDKQEVEDEESTGQSQVNEEVEKLIKE------VRIWESESKSILDLLRHQ
-DVD--GSSEDTLQHLIAKGSMYEELLARTEDTLQMDVQSASNLES---FQNVLRAGLQA
KIQE-AKEGAQIIVVELSAVCKNLRDG-SPEVDVRRKVEEARKDLESYITRAQQLLGERE
RPGGLISKYKEALGIFNTNSLAKYLQAVEELQRNVPGDAE-HLEEQRRDVCAKWEPLHHE
ISLYIQQLKIDMEEGKLRDNIAKLEKQINKEKKLIRRGKTRGLAKEHE--ACFSPESVAG
QLEHHVGVLRVLCEE-LP--SPERQQELKRALRDYEQKIQRLLKCASEIHRTL-----QS
SQG-GP--LEERDALTATENGGRDAPSEALLETPDNQLPTEK---A-MEPVKNFSQTPDL
KPQPEESIMEKEGKDCSAPLNDLRERYDTQREILEQHLRDGRARLSADFPSENERTSACL
QAKLADVQ-VLTADTDARWSEFEVTSLNLESLVSDPEKP-ALAQARDLFEEEKHELQRLL
STRMESLEMALQIVLPLEKECARLCDPH-LPFCTVALQGLHPVELDGIYQNLRD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DAIAKQIRICANL-KEPSDSIPRDLH
TLDQCAIQDIVLKCRLQLEAMNRKAEMREDALEALEGFLASLRAAKLSAQPP-ADPRASS
ALEDA---------PEDILLMNEKAGPLDERLRMLGIDVKDAEGGEHTTCEKLLGAVPVR
FSDSRGQSEQEGLTEDKTLLEA-------CSSKNHELFKNIQDIQNQIGKIGLKDPTAPA
VKHRKKSLLRLDKDLDGFEEEKMRIQKMADSLPEFKDGKEKMVIQQCQDTAALWEATKAS
LTESLEQCGSVLELLKQYQNIKNNLTALIQKEEAILSQQASYMGRDNLKKKVAEIETVKE
EFNEHLEVVDKINQICKNLQYHLNKMKTFQEPPFEKEANAIVDRWLDINEKTEEYGENLG
RAVALWDKLFNIKNSIDEWAAKTLGTVEPQQLTEEDRERL-------ERKPCQLTVQAAL
LQASW----------VMESSVLSKMRDVKRYITGEPNSYVPSGNTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMTVLENQIGCLTPELSELKRQYSSVS
DLFNTKKSALQDHFSTFLNDQCKNFNDWFSNIQMNLKECFEPPETKLSMEQKLQKLSDFL
TLGGGNSKIQQVETVLQHVKMLLPKAHVKELNSWLSSQELELENLESACQARARELNDSL
QQLLRLDDDCQSLSKWLTNQEEKWKEKEPAGEKTVLFYQALTRKREQFETVARLNDSLKE
HGL-TQA----EETVKESTHLIDRYQTLLRQLHEIEEEDKILPAEDQSFNDLVHDVTHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTVMRQAE------HCETPL
V--QETLTDLSNQWDNTLHLASTYLSHQEKLVLEGEKYLQSKEALRLMLTELKK-QQEAG
LALQPGLPEKQAQLKICKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEESWLEIKQ
LHESLLQQLQDSVRKLEGHVQEHSSYQVCITDLNTTLDNISKEFVSLCDASEDQITVEDR
M-QKLQELESGLGCQGGALKKASALAKSIKQNTSSVGQKI-IKDDIESLKY-KQKNLQNR
IESAKRDTENGLNSVL-QSKSSAEK----HAEF-SPPGGEMLATSDVPEPTQESAAVGGS
EGSWETNK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLHVQESMQNSQDERKVNELRNQPL
ELDIMLRNEQLKGMEELCTHLEARKAAIELLEQTQHLSKTEERASALHTARSPAYHVDSL
LQALLTLKKTKESQYGLLYGFQDLLVAAESSLNIFLAETESLKA-GSLDSAAYLAKIKKF
LGSVEKEKSSLSKLCMKWPHLSGHLSAEDQKLVESQMKQLEHGWELVERLAHKKCFQQAT
EHGELTSLLQKAQDIGVSL-H---QQQQRLLLSLNSPGQQEGSLDMVAPAAEIQAIKYEF
SGLKRQAELQMKRLWGEREKETLEGALNSLNKQLEAL-VPLNREVE-----NQVKKCDLK
NRIKETLLWVKNMLAELTAPIALLPDDILSQIRKCKLIHDGILGKQQAVELLVEEVRGIT
PSLPRSKSDGLNTLLEDLQNQYQALLLKSTQRSQQLELKLEERSQLFAIIGKAQVVLGQS
EPLMVPPQEKTSATEAELERRQAILKASQQQLRDTESEISAHLQELTNAYEDANVFERLF
LDDQLKNLKTRTTRAQRSIQNHCNEVEGKIRSLREFHEKTAGLQKEVES--IQLGELLPL
PQ----EPTQDAREQLGHLKNKMAALQGNISQALTSEEVFDCVGLGWDGSLLE---QLQT
QVFERQRDLEEKIKQLDTFLIARDRYQALLSKIKAMDLQIKERAKSLLTGPNMSP-ESTL
LHAQLLIQKIEKAKCLRDEVMEKLIENEAFDDSFKENEMLQLKLTAEENAGLREAL-QNM
LLELQPKGMDEKAFQDKLENSLRVLKQIQTRLQQPLCVNLGTQHIQDEKETWEAFGEQVQ
AEMCGIGAVTVTEEQRQ-DNPS-GTSGVEAKLQDLEGLHTELSKSIDLRTNVLNDAYENA
SHYDETVTRAVGIIRSLEAMLLSYRVDLHHPKESLELARCK-QKELQSAVTDIQNLTETL
GTIYSPEAKEQLQRTLQELASKNSALKAVLEAQEAEDG--RCL------ENYKRYGKMKE
DICSRLRKMETDLGQSMSSWPRSYKEALGRLDQSKALTSSVLSIQEDLVTLRQVLRPLSC
RCTVSEGACVRSAASALWEKWLRLLEAARGWQQWCGELKREWKFISEEIEREAIILENLQ
EDLPEISKTKDSAPTEELCQLLDSLCQHEESVEKQLLLLVLLLQRITSIQNIPQGTETAE
T-IPVLQEIRSMQERCIRLLQAAQKNKDLVQTEIQARHSFEKELTDVKHSFEQISTSFQD
LALEGHPERAEQLEELRSVLQKGKLTLEKVMEKLRIKYSEMYSIVPAEIESQVEECRKAL
EDADEKITSEISTHSPSGVMGRKIEEINNGLHGIETMLQQKSKNIEDAQEIQKKIWDELD
LWHSKLTELDSEVQDFVEQDPGQAQEWMDNLMAPFQRHQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIEKTNRVLANPACYDSSKTLSQRANALQMA-LDDGEQRYSLLHSVFTD
LEDLSVIFETDDLIQ-SLQELSGQVAALQQQIEEALPHIQQVADDVVAIQSEVKSMEKKV
AKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQAELRLPQTGPKPLPVFQRTNQLLHDVKLLENVTQEQNEL
LKV-VIKQTAECDGEIEDLKLILSKSSAEFSPERVSRKQAADLPSSQG-KMEGLEKQILN
LNQKKDDLLVGLKAAVLNLHEHLKQEQQEGE--GEELSSAPS-EEGGVPER-GAPDRKL-
--KRASSMSFLPVVKEEAEESSVKSEDGHKRTEPPCAS--WSLLWKHNQDLEEEDGA-SS
SSATIVQE----ADGRISTCDSSMAHIITPDSGSTA---QGPEPSPRPSRTAEGATPPTE
ATPLDFPHEQG-ALEATV--ERSRPQPAEVLHVCKTQVAELELWLQQANVAFEPETLDTD
MQQVVEQELAGCQAMLTEIEHKVASLLDTCRDQGLGDCGATQQEAEALSWKLKTVKCNLE
KVQMMLQEKYSEDQ--HPTTLKKL--S--EPHALHQPVSLPELESLVTERPQFSRQKDVP
QAQ--VLELKPLEQKDLIKFTEFN-AQKTWLPCCQQDEDA-NRQPAS----------SSK
VPLPGNAAPDSAWPLQGQ-SGDKWQY-----L-YHELTSRPNPPGP-QLVEPQVATNTST
LPSVSVYNFRCPTSEELQTYTTQLEDLRQEASSLQTQESMTEETYMNLDKSLFELFLSLS
RCLGSVEELLQRPGLLREDASAQQVLF----EKLALELKKLYLALGDKKDDLLKAVTWPD
ENTTLLPECFNALKVSLERTQAKAAWRSSSLKAGLDHTRSYQNETKRLYNQLIKKKMALQ
QSLNEIGGQSIGEQLQKADVHTAELQNAERQVAKLRNEGERLRFPHVLLQDVYKLEDVLD
SMWGILRAKYLELSSLFLPESQQDALLQGMEELVSIGKEKLAAGPLQHAKSKVALQAQLQ
DHKGFFQKLVADMLLIQTYSAKMFPPSLQKGERFGAQQVAEVRAVEEAACLQGSQLQSVL
QKWEAFDDSYASLEKDLEVLIASLPSVSLVEETEERLMERISFYQQIKRNIDGKHARLCQ
TLNEGKQLAATVSCPELEGQITKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYSR
DSAELSRWLESSQQTLNYWKEQSLNVSQDLDTIRSNINRFFEFSKEVDEKSSLKSAVMST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSRNAISEMIGW
MNAVEPQAAGEDTELSHRSASQVKSLLQKLKEFRMEMNYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVLGALNRKIQHLEQLLESITENENKIQTLNSWLEAQEE
KLKILQKPESAISMEKLLLDCQDIENQLAMKSKALDELRQSSLTLEG-GDIPLLEDMASG
IDELFQKKSHVTGQVHQLRASAQSALQEWKACNKLYDEANVVTIQLAYSMEHSKPAV--L
SMEALDCQVQNLQALQDEAERREGSWGKLQEAIGRLKDSC-PSIAGIMEEKCQDAH--SR
WTQVNQ---DLTDQLQEARGQLQLWKASHSAHAEAAAWLRQQEVKFQQLANINMSGNNLA
DILPLALQDVE-ELQREVLKTKEAFLENSPLLDQLPQ-PADRSTPGLHSGQLHSLQTAAY
LEKMLLAKANEFKIVLAQFKDFGDRLTYLQDLI-MHEEENLNKLYHEEK--EDVPGLFLN
HVLALTAQAPDIERLNEESLRLPLSDITIKTLQNVNRQWIRATATAL-DHYSKLQGNGLN
-EN-FLHYCEKWIQLLEKIQETLTVNAAHSLPALLERQKTYEMLEAEVSINQTIADAYVA
QSLQLLDTTEAEKRPEFVSEVSKLSDQWQNAARGVQQRKCDVDGLVTQWQFFT-TSVE-D
LLRFLTDTGHLLSAVKEQDCYSLYQTKRLIHELKNKEIHVQRWRTTYELALEAGEKLRD-
-TPNPETQEFIDRQASKLQDAWKDTELSLREMISQLQSTA-ETWDQCEKKIKELKGRLQV
LKAQSKDPLPERHEDLHRERELIKEVETSLASWTHNLKELQTMKADLSQRILAEDMTVLK
EQIELLHRQWEDLCLRVTVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EISLFSENK-LQLKQMGDQLTKASSKAKAAEVEDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGELLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPSLEDEKEASENETDLED--PRELQADSWRKRREMEE----
ASPPQSLC----HLVPPAL----GQERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISEGHP------
------------WHVPDSPSHPKHHYKPMEGDKAVAPVPSDASTPYKPAYVKLLLHQGT-
DDGKEG---PG-------Q-ED-EQLATLTG-QQ--PGAFDRWELIQAQELHGKLRLKQN
V---QQLNADIGTITAWLEKTEA-ELAALRLAKPPSDIQEIALRVKRLQEILKAFDTYKT
LMVSVNVSHKESLPSESPESTE--LQNRLHQLSLSWDTVQGVMDSWRGDLRQSLMQCQDF
HRLSQDLLLWLASAESRRQKVH-V-TSPEADRQLLLECREELMQLEKELEDHQPQVSSLQ
EISSSLLVKGHGEDYIEAEEKVHVIEKKLRQLREQVAQD LVSLQGSLTPDP-SLAS----
--YD--EVD-SGE-EPPAACAKVSE-----------RSTEEEEETD-------SRMSHLD
DPG-RSPPRRS FLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLPTEDE-PA-SLGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHNPPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNQS------IKLINIHVTDIIEGNPSIILGLIWTIILHF HIE----ELARTLSCD
YNQ-----TSLEAVSVV-D--SSPTSSPPAKKCSR--AQARWQM SAKKALLLWAQEQCAT
-FES-VSVTDFKSSWRNGVAFLAIIHALRPDLIDVKSVTHRSNKDNLKEAFRVAEQEMKI
PKLLEPEDVDVMNPDEKSIMTYVAQFLQYSKDAPRTGDEALG-RVRDAM--------VWL
TLQEEKLQKMLNDSENETFLKKYHN----LLSFMESFDEEKKFFLDVLSQTRNLGELNED
QLKLRETWDGLNHQMKAWKTELNYALPPPLQQIEAWLQEVEVLMEEDLPTSQDYSEAMTL
IQEKITLFKHLMDRFDCHSNSLLTFENRDENHLLLVPPNKLDEMK-RRI-NNILGKKFIP
LLEFHYYKCSVLGLLDEVKSKLDIWNIKYGNRESVELLLEDWQKFIEEKAFLAQLDTGFR
KCEEI---YKN------LAGEYQNINKQYMMVKYNVCMYRKNISNVKSTLQKVLTCWATY
VEKLHSLKSCFEDTKKEQIKE-----IPFETLSQWDAEHTTLNEAGNFLIEVSNDAVGSS
ISKELRRLNKRWRKFISKTQLEMKLPL-I-KKQDQPIFDNPGN----------V-L-SVE
EKPTVEFSTDVSIKRSEDCDR--NIK----------------------------------
--------A-GKHELEIKEFTGQLKVTEEVEKLIEQ------VEIWEAESKSVLDLLRHQ
EDVD--TPVKESLQHLIAKGSMYDELMARTEDTLQMDIQNISSQDS---LQHVLTAGLQA
KIQE-AKEKVQINVIKLTAVLKNSTDV-SPELDVRLKMEESQKELEAYITRAEQLLGKRE
NPRGLISKYKEALIISNTKSLAKYLKAVEELKNNVTEDEKMSLEDKSRDVCAKWESLHQE
LSLYVQQLKIDIEKGKLNDNISKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLS
QLRHHMDALRGLCEE-LT--SQKKQQEVKRLLRDYEQKIERLLKCASEIHITL-----RS
ALG-GP--LKNEGTMTTSEDTGRDSHSEVPFAKSDNQPSTKK---A-MEPITNFSLASEE
KPQEEESIMEKYEKGPGASINSLLERYDTHREILELHLQNNKSRVISDFSPEKERDSSCL
QDKLIDLQ-VIN-ETDACWKEFEITSLKLENLVDDIKKH-FIVKERDRLKEEERELQITL
NARMESLKMALQIVCPVEEESRALCGSD-LPLQEVAIQEFRLIDADGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNNL-EEPNNFVLKELH
PCDLHATQNIILNYKTQLEEMNHKVQTREDALKVLEDFLASLRTAKFSVEPI-RDLSASD
TQVAPESTLMVKT-EGEIYLMKDKARHLDKQLKMLDMSFKDAERGEDISCEQLLDALSIK
LVETLGCSAQEELTEESKFLEA-------CLLKNNELLKNIQDVQHQISKIGLKDPTVPA
VKHRKKSLLRLDKDLDEYEEEKKHLQDMASSLPHFEDGREKTLNQQCQNTILLWENTKAL
VTECLEQCERVLELLKQYQNFKSILTTLIQKEETVISLQASYMGKENLKKRITEVSPAPE
R-----------------------------------------------------------
---------------------------RVSQLSEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSTEIPLELQVMESSILNKMEHVRKCLTGESNCYALSGSTAELKEDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNTKMSLKECFESSETKKSVEQKLQKLSDFL
TLEGKGSKIQQVDTVLKHVKKHLPKAHVKELNSWLVGQEIELEKMESICQARAKELDDCL
QQLLRLQDDHRNLSKWLTNQEGKWKEMEECGEKTELLCQALARKREQFESMAQLNNSLKD
YGL-AEE-----EVMTESTHVIAQYQTLLRQFGEIEEEDKLPPAEDQSCDDLAHDVIHWI
TEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIETLMKQTE------SREVPL
A--QKTLTDISNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQPGLQEKKTQLKIYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLNTALDTFSKEFVSFSEKPVDQLAIEKK
L-QKLQELENRLSLQDGMLKKILVLAKSIKQNTSSVGQKI-IKDDIKSLKC-KQKDLENK
LECAKQEMENCLNSIL-KSKFSTEE----KGKS-ALLGREALATSEVQESSQEPAATEKL
EEDWKVNK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSALETVMSKQLSLDVQESMKNTENEQKVNELQNQPL
ELDIMLRNEQLKEIEELYTQLEAKKTTIEPLEQSECLSETEASSVVLHNAEYLVHHLDNL
LQTLITLKKNKESQYCLLNDFQEHLTALESSKKDLLTDKESLKV-GPLDSVTYLDNIKKF
LASIEKDKGSLSHLKVQWENLSSHVTDMDKKLVESQIKQLEHGWEQVEQLLQKKYSQQVL
EYGEFTSLMNKIQDTEVSL-Q---QQQQRLQLRLNSPEEQEGNQSMIALATDLQAMKYGF
CLLKGQAELQMKRIWGEKEKKILEDAINNLKKQLEAL-QPLYLEVE-----NWIKKCDMR
NKVKETVSWIKNLLGELSSPISLFPEEILSQIRKCKVRHDGILGRQQAVESLVEEVKNNI
PSLTDYEGDDLNSLLEDLQKQYQMLVLKSTERSQQLEFKLEERSKFFTVIKKFQLTLQGN
ETLIIPKVEAIS-TETELENHHATLTASQKELGEIASVITTHLQELANICEDLNVFERLF
LDDQFKNLKTRANRTQRFIQNKCNEVEHKISLYKEFHEKTSVLQNEVEG--IPHNEL--L
NQ----EINQDMKKELCNLKNRLTGIQCSVIQVLKFKKVFDYLGLKWDCSQLD---QLQT
QLLEKEKELEERIKQLDTFEVELGKYRASLSKMKAMDLQIKKRTEAVRKTPHTSP-ESSL
LSAQILSQRIEKAKHLYDEIIKKLNENKAFDDSFKEKEILQIKLNTEENEALHEVL-QSM
ILEFQPKEMDEKNFQNKLENSLHVLNQINSQLQQPLLINLEIEHIQNEKDNCEAIQEQVQ
AEMYSIKAVTVTEMQSK-ENSP-ETSDVETKLHDIEALQMQLSTSIDLRTNILNDAYENL
TRYKEAVTRAVEIIASLEASIATHRVDLDSPEKSLAMPLWE-QEELESTLAVIEDLTEKL
GTISSPEAQLQLQCTLQKLVCKNLALKEATKVKEAELE--RYL------ENYKCYRKMEE
KICTNLSKMETVLGQAMSLTPVSYKEALERWEQSKTLVSNLLLTKEELMKLRQSLRHLRP
RCTENDGMCLLRTMSALWEKWLSLLEAAREWEMWCEELKQEWKFVSEEMEREAIILDNLQ
EELPEISRTKEAATTEELSELLDYVRQYEENVEKQQLLLTLLLLRIKSIQNVPESLGTVE
T-VPAFQEITSMQERCTKLFQKAQKNKELMQTEIQERQSFTKEIIALKNLFQHTITSFQN
MATQDPPEKAQQFEQLQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISHEVLKSSPSYTMSRKIEEINNGLQNVEKMLQQKSKNIETAQEIQKKMWDELD
LWHSKLNELDSEVQDVVEQDPGQAQEWMDNLMIPFQQYQQMSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSRLLANPADYDSSRTLSHYASTLQMA-LEDSEQKHNLLHSIFTD
LEDLSVIFETDDLTE-SIQELSNQVTALQQKIIESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIVSYQVELRLPQMKMNPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPEQAANLPQVQG-EIEGMEEQILN
LNQKKDDLLVDLKAAVLNLHQHLKQEQPEGE--REKLSAVAS-EEGGVAGR-DVPEWKL-
--NRKGSLSQLTAVEEEAEENSMKSENEDKEAEPPCPS--WSLLWKHDRVM-EDDRA-SS
SSGTVIQV----ANEKISTCASSMVQILAPDSLNIA---QVPEFSLEPNQTEEGATPLSK
AVALDFSEEPG-NFEATV--EKTGPEPAEVLHVCKTQVAKLELWLQQANVAFEPETLDTD
MQQVVEQELIGCQAMLTEMEHKVASLLENCKDQRLGDCGAIQHEAEALSLKLKTIKCNLE
KVQVMLQEKYSEDQ--HSTILKKP--S--EHPKVLQPVNLSELESIIARRPQFNKQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-AKKMWPQSHQCDKDI-TQESSV----------SNQ
ASSPENDVPGSTLSPQGQ-SREKWRY-----L-HHELSSRRRLPLP-QLVEAQVATNLSV
LPSVSVYNFRYPTTEELKAYTIQLEDLHQEANTLQTQENVTEETYICLDKKLFELLLTLS
QCLGSVEEMLQTPGLFREDACAQQVHC----ETLALELKKLYLVMSDKKGDILKALTCPG
QDTNLLLECFDNLQVCLEHTQAVAASRSKALKAGLDYNRSYQNEIKQLYDQLIKNKTSLQ
QSLNEMSAQSLAEQLQKADMYTVDLQNSENRVAKLRDEGERLRLPYALLQEVYKLEDVLD
SMWGILRARYAELSSPFVTESQQDALLHGMAELVDIGKEKLARDHRQHTKSKGALQAQIQ
NHKNFFQKLVADMLLIQTYSAKMFPSLLQKKEIFWAEQVAEVKTLEERSCQCGMKLQGLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLAERISFYQQIKRNIDGKHVRLYQ
ALNEGKQLVAAVSCPELEGQIAKLEEQWLALNKKIDHELHRLQTLLKHLL------SYNR
NSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVISA
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITETISW
MNRVEQQTAEEDAMHSPSSVSPVKNLLQKFKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNHQWHRVHGMLNGKIQHLEQLLESVTENENKIQILDNWMEVQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELRESCLTLES-GAMPLLKDTASR
IDGLFHKRNSVTTQVNQLKTSMQSVLQEWKVYDKLYEEVNMMTIRFWYCVEHSKPVV--L
SLEALKRQVQNLQSLQDEAESSEGSWEKLQGVVGKLKGLC-PSVAEIIEEKCQDTH--TR
WTQVNQ---AVADQLQKAQHLLQLWKAYGSAHTEATTRLAQQEAKFQQLASINMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSTLLDRLPS-PAEPSTHTLLPGHLHSLQRATY
LEKMLLAKANEVEFVLSQFKDFGDRLESLKGLI-MHKEENLEHLYQQEK--EENPDLFLN
HVLTLTAQSPDIEYLNEVSLKLPLSDVALRTLQNVNRQWIRATATAL-ERCSELQGNGLK
-EK-FLYCCEKWIQLLEKIEETLKVNIADSLPALREQQKTYEMLEAEVSINQTIADAYVT
QSLQLLDTTEIQTRPEFVSEFSKLVDRWRIAAQGIRQRKDDVDGWVRRWQDFT-TSVE-D
LLHFLTDISHLLSAVKGQENYGLHQSRSLIHELKDKQIHFQRWQTTYALTLEAGEKLRN-
-TANPETKEFLDRRISQLQDSWRDTELQLSEMIKQFQSIM-ETWDQCEKKIKELKNRLQV
LKAQSKDPLPELHEDLQNKKELMKELEKSLANWTQNLKEVQTMKTDFTGHILAEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWVVFNEKNKELCAWLVQMENKVLQSADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-SQLKQMGDQLIKASSKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVARFHRRLTSRAPGLEDEKEASENETDMED--PREIQTDSWRKRREGEE----
PTSPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEVPFYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSSPCPEHHYKQMEGDRNIPPVPSDSSTPYKPPYVKLLLPPGT-
SGGKEG---PCILNGSPEQ-DD-EGLAGTGG-QQ--SGAFDRWELVQAQGLHDKLRIKQN
L---HQLNSDISKITTWLKKTEA-EVEMFKAAEPPSDIQEMGLRVKRLREVLKAFGTYKV
LVASIHANSKEFLQTENIEATE--LQSRLGQLSLHWEVAQGAVDSWRGGLRQSLMQCQDF
HQRSQNLLLWLARAEERRQKAH-V-ADPEVGSQAVLECQKELMQLEKELVERQPQIDSLL
EISDSLLIKGHGEDYIEAEEKVHVIKKKLKQLLDQVSQDLISLQGSQNPDP-PLPG----
--FD--EVD-AGD-QPPAASVPAPRA-KVRT-----ERTTEGGKEA-----------ESR
ALG-TARPRRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QG-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPASSPPAKKCSK--VQARWQM SARKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPGLIDMKSVKHRSNKDNLREAFRIAEQELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQG-KVKDAM--------GWL
TLQKEKLQKLLKDSDNDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKRDPDELDKD
HLQLREAWDGLNHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQDKMTLFKSLMDRLEHHSNILLTFENKDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVSMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENYNQ--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DDVD--TSMEESLKHLIAKGSMYDELMARSEDMLQMDIQNISSQES---FQHVITTGLQT
KIQE-AKEKVQINVVKLIAALKNLTDV-SPELDIRLKMEESQKELESYMMRAQQLLGQRE
SPGELISKYKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--TCFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TAG-GT--SKNEGTITTSENRGGDPHSEAPFAKSDNQPSTEK---A-MEPTKKFSLASEL
RPLQEESIM---EKDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENHVNDIKKP-FVIKERDTLKERERELQMTL
NTRMESLETALRLVLPVEKASLLLCGSD-LPLHKMAIQGFHLIDADRIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAELSAEPV-TDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIK
LSETHGCGVQEEFTEENKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTYEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWLTNQEEKWKGMEESGEKTELFCQALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMESTCLMDRYQTLLRQLSEIEEEDKLSPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIVVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLQC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLNAQESMKNTEDERKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLQAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGGDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAMIRKFQLMVQES
ETLIIPRVETAA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LEDQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEVDS--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRR
LNAQILSQRIEKAKCLCDEIIKKLNENKAFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQGQVW
AEMCSIKAVTAIEKQR--EENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKEAVTRAVESITSLEAILIPYRVDVGNPEESLEMPLRK-QEELESTVAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKAQETEAE--RYL------ENYKCYRKIEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQRMADDMVAIESEVKSMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENMTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQLQG-EIERMEKQILS
LNQRKEDLLVDLKATVLNLHQHLKQEQEGVE--RDRLPAVTS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTSDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
ADTLDSSDAQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAVEPETLNSD
MQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHQEALQPVNLSELESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-TQESSA----------SNQ
ATSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQHEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAYRVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSGPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKMLEEKSRQCGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVISI
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSMHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSRALDELKQSYLTLES-GAVPLLEDTASR
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHSEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSSVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGVRLESLKGLI-MHEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT-TSVE-N
LFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTYALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADINI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GGLAGITE-QQ--SGAFDRWEMIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TDPKADPRALLECQRELMQLEKELVERQPQVDMLQ
EISNSLLIKGYGEDYIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPAP-PLPS----
--FD--EVD-SGD-QPPATSVPAPRAKFRAV----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------------SSSSPQ-MT-SWEVSGISP-----KNT---------AEQENTQKKTF
TSWINSQLEKHSPPSFILDLYVDIGKGHALLDLLEVLSGEQLPREKGFKTFQCRSNIENA
LTFLSNQS------IKLINIHVADIVEGKPSIVLGLIWTIILHF QIE----ELAWTLAGG
YGH-----PPVETPAATDN--TSPTESPPAKRNAK--AKERWKISA KKALLLWAKEQCAK
-HGS-VSVADFKSSWRNGLAFLAVIHALRPGLVDVEKAKGRSNQENLKEAFDLAEKKLNI
PRLLEPEDVDVTNPDEKSIMTYVAQFLQYFKSLPVVEDEMQG-KANETL--------SWL
EAQETKLTELQAETDNAPFYEKYKE----MMSFMETFDEEKKAFLPVLASKRKPLELSED
QLQMREAWNILSSQIYEWKGELDRLLPPPLDTIELWLQDVEHQMAEDLPDSHHRCKAIDV
LQGRMKSLQGLMAYFEQHLESLLSFENRNEISMPLVPHQKLEEIK-KRF-NNIQTMDYSI
LVEYYNLFCSA--ILEELISKLNIWHIKYGTKEEIESLLSDWQDFIEEKGFVSQLEVAFK
TCDKV---TKQKI----LGVDPDDINKQFKMLESQISRCKEYIYNVNETLQKKISSWAIY
TENVQLLKEWLEKTRKEHPKK-----VPTETLAAWNSRHGSLNEAGNFLVECSNEEVGSV
VSAELKNLNTKWAKLIKKTQFEMRLLK-M-QQEEMGL----------------T-SD-NN
ENVDSPPVKADIVDMPGHQLN--VSD----------------------------------
--------EALENMKVSQQVDEST---PAFTLNFSGAIQILKIANRVQCPGVFQRDLLTL
GFLN--VSNRALLAQYIFCGPMYIDIKIKYFLIINQHLQGLLNRLIFFSIADCKCSALEK
NVQPLPEEKKHVKVTKKFLAFGCILQI-SPEQEVKLNFEDSHKKLEATVLKAMQQLCREK
GPERSMSKYEEAFSILDASILGEFLKAAEQLKDISAAHDKAVVEEKSKDVRERWEAARRE
IISYMQ-FKMEVERGQLNKMFTKLNKQINKEKRLLNAGRTKGLLEEHE--DMFSQQGRMG
KLNSCLQAMKMMSEK-LA--IEENESETKMLVAEYEQRKEDLQKRASVIYMDLHKIHCLT
TSEILT--IRTTSENNNSNQNSRSSYNNDDNNSCSCHHKQIT---M-----SGRLRSFMP
PLFSERVCNLHHVAILHLPPQ---NTYDRARHTLKLHLSSVRENIAPAFTLDI-KDASCL
QNKLNELE-ALESQSESSWKVLESMCIMLEKSSGEMGKPDAFEQSQEELCREWKELQSTL
NKRMESLRTVLALVLPVENELIQLCNSE-EQLRKKDIPQGLLLNRDLPHKKVKN------
-MQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ASIVKCIEWCNQ--KKQNNPTGGTVD
PADWQVASTMISQYKMQLEELGHKIHTVETILQDLETFQTYLRKVSGPVEAS-DPLSHPQ
QP----TECL--VQQEVWKMQK-EARSLDDRLTRARIRLEDPDSGKKMSFKELVATFCAK
GIPTASSAETLEVVQNQDVQNQVVQNQEEFPLKSNELYKNIQEIRDKMCKIGLRDPTIHA
VQHRLKSLAELKQMFDRCAADMGSLSETASCLSQ------KELKHQWSRTEDLWKETKLS
ISEKLEHCGRVMELLKKYHSCKNCLMSIILKQEHVLSQQTSYMGKANLQRITAKVNKAKQ
EFNNHSEDVDRINQICKNLQSQLNKIKSFEEPPFENEANAIVDRWLDVNERTENYCDSLG
RALALWDKLLNLSSLIEEWSNAQLKNLEDGSPTEKELAELEAGIEFQEKNLEEFDTKVAE
IQILLNGSEPPLELQVIKSSLLNKMELIRKHLPNKSIPAELNGNTAELKGDLDLAKTQIG
MTESLLKALSPSDTLEIFTKLEDLHHKILQQKHHVESLQKGPGYLNPEVTELQEQLKSVT
DLFNSKKQIFQDHFTTLLNYQCKNFDDWFSSTQLSLEECFETSETKEMLEDKIQRLRSFL
TSEGKDRDIQEVKTLLSQVKHYLPKATVGQLSSWVRDKDVALRKVTSRCQAEEEELCISL
QRFARLEDDCSSLTEWLHLQELQESQI--ERPEYEHFYQTLLKKRESFDSFAWLINSLRS
SGF-T-C----DEVVLESAQLVSKYKMLLGHIRKNLGVSKVLSAEGKNFEELAQNVFSWV
QNMNELVLRLSSEDSKTSLEEKLCQLKEIVLLKEEGNAKLENVAALGENVKSASGSNNEA
V--QQMLSDVQNQWESTIHLATECLRHQKQLQQQRKQQRRGKDDARAVPCDSETQNQEIS
LDLYLDSEEMQSQFSNYSALQEEAEDLTLLLNELARQ-HSSFGVFTDDSFSEESLMALQQ
LHGNLVNRLQSTAILLEGHAEEYQRCKELMAHLRATLDDHLKPMVTLSQGFLEKVSSEES
F-HSFQHLSSSLKIQQDTLCRIEDTLQGIIADIEILKEEMCIKDEMDAPHSICKKHLKIK
VGNMEEETRNVVNNAF-KQNNRFSDDGQTQETTEELF---------FDAEENNAVEVQAV
PKFWEKNQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------VSGVELVSQKNLLPEDKILTEYAEMERKVNEMKLWTA
ELDIVLVNDHLKEIESLCAHLKKQRAEALSLLQGEHAKAGGRSKSD--PQHVASSRWDKL
LQDLMAVKKAKEEQLDLVNNYQECFTAVQSSMKRFSAEKENLKIRGPMEDTIVLENIKKC
LTSIEDERVLLNKLKTEQESLSRHLTKMDKALIESQVDQVERWWQQMEDSLQKKQLWVLA
EADEFKLFTDKMQDLQNKI-Q---E-QHRLRTGLDAPNGGDSVCSAL-MGPELQMLKHSV
CLLRRGIEMQMKRIWSDAGKTALESQINDLQNQVDEL-EQLTPKEEVQMMGNYSHRLEIA
KKIEEAILWARDLELQLDEKAALFPGELMLQIQSCQALINVAKEKESAVMKLVEEARLVA
PQLAPREFSALGLLARELQTCHRRLVLKLVQRVQQLKPQFEKRQKLFADVEKAQSQLWKA
ESMSRLDAGEAS-VESEMDPWQVVSEELSQEIQETEGLVDANCKDP---PQGLKIFEQLF
LSDCLRSFRSRAKRALRLIQIKDFTVQNKIDTCEKLSEKIIALQRDLSSLCLQCNELE-L
DQKKLFPMNQEFKSKWNALRERTISILECLTNLDRYKEIWEFLGLNWDASCLG---ELQS
QLCKMKNHLEQRVKCFESFSTEYDRHQTALNEAETIVSNIQRNCNALKDCSDVTS-ETNL
IPEKILSWRVQHGKRLTQEALRILDKNESLSIPLKEAKMQEIKSLRAKIEGVTQMI-ESR
MLAAQEKLQPEQGLRSIVNHSLVTLKQIQSELQQPLLLDLEIQMIPCERMYCEVLENAAE
AECCAVEELLQRESEEEKSPF--LDI-LGTELETLRNLKKELKADIASRRDAIDEAFGTV
RCYSEAVQKAAGLFRQCEDLLSSPALSLDELEEESLLPILQTQEQFEAAKTEVEALTSVL
EKQVKQRANLHLQKTLGELVAGNLIVAEKAQKRRSDLQ--RYYCIYRCLEKYQHFKKSKD
AICADLNDVKKVLQKAMGHIPVSYKEALELSEQSKMQVSRLVSTEEDLMKLRQDSGHLSL
MCKESDGLLMCTVASTLWLKWLYLLNAAKEWEGTCEEQSQEWKSISEEMERETIILDNLQ
DELPENPKEKENATKEELDEFLDCANYYKESLDAEKLLLRLILQRLRSILGVPESPPGKK
EDIPVVHEIQAMQERIKEIREKVQKQKDAVQLEKEDRAKVNEEIHAVKSSLENTLSLLHS
VDGETLNEKAAKIEEIQRVIGPQKQTLERIMEKLRIKYADMYTIVPVEIETHLEDCKETL
KDLEEKVSDELLKNSPRYITDKKIEDINKGLQAVENMLQQKSEGIEKAKEIQKRIWDLLD
LWHYKMNELDAEVQDIIEQDPCQAQDLMDRLMIPLQQYQRVSQLAERRTTNLNRASSKME
ECDELLKSTQVWIESTNNLLTEECQGDSAKTLTKYATSLQIA-FEDSEQKETLLSAIYPE
LEELSTLVETDALLR-ELNNVGKEVKALQEKIMGILPHIQHLADEVEAVESEVKKMEKDV
DKIKTILSPSEDTLDFSPKEHLKHGQ----------------------------------
-VIVVHISAMQNQLMEMQSYEENLKLPNMRVQPLCVFQRMKHLLKELKRLERITQTQNSL
LEP-IVKEVEANEQETDCVKQLLFPKSDLGESSADFPWPGEAAPQNEGVEMEEIKQRIAI
LCQKKEDILMSMKNSLMELHK--QQEQPDLE--DDTEESQES-EENGD-----GAAWQP-
--KKRGSVSFLPSLAEEAEDRSFHNSVSTANALDNPEP--WISESWIKAKS-LEIQD-RE
RHG---------QTLALQVFWTPTSTIPNSLP-AVR---NCFELSFLQGK----PSTEVT
NAPECFRTSLQ-ESKEIVDSDGLESDPAQVLHVCQAQIAELEMRIKEAKESLGSEAQTGQ
MQQAVEQRLAACQIMLSEIEQKVTCLLENCKDRPASDRPNLQEEAESLSLKLRDVKLSLE
KVQGMLQDKHVEEEFHGSLGEKTS--E--ISSQHLCFGLSSIFPLISSDRPVLSKTNGLQ
HQQ--ELFSELSEQSNLIDFIEVY-VGKM---QPQSEHST-NLELQP---------RS-S
HEAPVSKDEPNFLTPKDQ-TGDKWQY-----L-QEQLLCKKSPLHF-ELIEPQISTKINI
LPKGATSSVKTPTVEELKKYTAELGSLSQIQSHMYIHENVAGDVSLSLDEKLFELLLAIS
RCLNNMEQMLSTSALTSEEAPVQQILY----ETLSAELQKLHADIGDKKEDLLKSITSAG
GNPERFSQCFSNLQAWLQQTEAATASRSKCMKTDLDRYSFYQNEIRELYDELIKKKSVMQ
QSFGATSSHDISMTLQITKDYELELQNFETRIAKLRDHGEKLPLPVALVHEVDKLEEVLD
DLWKILRAKQRELTSPFISEQQYEVLLQGLAELTDLGREKIIQISSLKATNQANLQFHLK
NHKSFFCNLKTHMLLVQMCSQKVAPSVLQKREKSWKELEKNIDSLEQQAIQHGTCLEMLS
QDWIEFDESYASFCQKLEALSSEVPSVSLVEGTEERLMERTQLLQQIKKNIEKEKARYGQ
LVKEGKDLMELLNCPELESQVGKLQEQWASLSQKVGHELERLDRLLRLLS------SYNR
ESKDLDRWLAVAQQRVNDWKEQSLDASQELSTVRDNLQSLLEFTKEIDEKYSLMSSVQST
GNQLLLIKESDSAVLRSSLTEYEQKWADLTTQLPGIQEKFHQLQMAKLPSHEAITELTAW
MNQIDQLKSNKATIDLQSSAGQVKNLLKEYKEYLLEMNFKQWVVDYVNQSLLQMTTCDVE
SKRYERTAFAERLGEMNLQWHKLQGALNEKIKELEHILESVTEKESKAQSLGSWLEAQSS
RLSEAEKPASSFFAQDTSEFCKEVENELAAKSKDVDQLKQMYA-LVE-HNTKASEKPVLD
INHLAELRANVSNQLAQLKTSTQSALENWRIYDEVWGEVRQMLARALYYSEHSKPAV--I
TFETVKNQVANLQGLQDKTENDEEIWARLQATVDNLKKLCDPLFLQLIEQKHQKAR--TR
WALINK---EIEDQLQKAQTYLPFWKSYVGVYAEVSAKLDKHEEQCNSLLAVNIPAGCTR
DFLKEKSQDVK-KLQRGLQNLKRSSLQVSELADQIAQ-LVEPTSQPLLLEKLHPLQRASR
LEKMLQMKASEFQFALLQLEGFEKCLENLENHL-KGYTEAQDHLNQ--E--DDSSDRLMS
QMLGLTALSPEMETLNEVSFKLPLSDVTAKRLQNLNWQWSQKTAMVL-EQCSELQTIQAD
-DKAFLQQCQNWVHFLERMKEGLKENVAGTPERLKEQQREYEILQAEISVHQQIFNCIMS
KALQMLESGEAENRTEFISKLTVLKEQWQSVVHMAQKRKSQIDTLVKQWQKFT-TLSQ-D
LRRFLTDTNGFIAATKSQDKYSLDQVRTLSHDFKNKQILLRRWQNRYSLALDMGRNLLG-
-AAAREAKAAIQHEMSQLQESWGNTQLQVEKMTKQLQSTI-ETWENCEKQVEELGHNLQK
LKAEVKNPLPGEHDDLQAAKEHVKDLEQSLANWNQRAKELGTRNADLAHYLLAEDVMVLK
EQVQHLHRQWEELCLRVSLRKQEIEDRLNAWLVFNEKNKELCSWLVQMESKVLQSGDISI
EDMIDKLE-----------------------------------------------KDCME
EINMFSENKLLPLKQMGDQLIKDSNKSRVAEIDEKLNKINDRWQHLFDVIGGR-------
---------------------------------------VKKLKETFTFIQQLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFSICEVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWC LWQRFLEDYSRFEDWLK
TAEKTAAYPNSSEVSYTNAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQRRVAAILRR LKNFTTQ WEEFVGTKDSVLVWLTEMDLQLTNVEH
FSESNFDDKMRQLN-GFQQEIMLNAKKIDQLTEFGEHLIQKSEPSDAVVIEEELEELHKY
CQDVFGRVSRFHQRL ANWHSGAEDEKESSENKADAED--VRGVHHDPWHKKALPDV----
PPPQHSLC----HLLPPAV----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSP--
-----EDE----EEERYYSALS----------------------AGTSASETHT------
------------WHSPESTACRKHPYNQREMVRSVLTNNPETSTPYKPGYVKQLSTGSI-
DSIKE----IPGILSTEHT-QD-TNIIGVSA-VEKQPGSMERWELLQAQDLSNKLRMKQN
LQ QWQQLNSDLTTINAWLDTMEE-ELEGLQEESPANSIQVIEQRVKKLKDMLKAFDNYKA
LVLSVNLTSKDFKQADSTGSKE--LQNRLRQVNFRWEKANLLMGNWRKGLQEALMHCQDF
HEMNQKLLLWLACAETRRHHAQ-V-KDPNADPHNIQESRKELMQLENELLERQLQVNTLQ
EIATHLLDKSGG-DYAEADEKVHVIGKKLKQLLEGVSQDLKVSQGSQDISA-FQMQ----
--GS--EVD-SGR-YHQLSEKPSTYS-KVFY---V------------------CRSEDGD
EAHPAGPKTLSFFYRVLRAALPLQLLFLLLLLLASLIPFSEEDYSCTHANNFARSFYPML
RYINGPPPT---------------------------------------------------
-

-------MASSPQLPTEDE-QV-SWGIDDLQI-----SLQ---------AEQEDTQKKTF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLFWAQQQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDARGTGEEARG-KVKNAV--------VWL
TLQKEKLQKLLKDSENDTYFQKYNS----LLSFMDSFNEEKKSFLDVLTIKRNLDELDKD
QLQLGEAWDGLNHQINAWTVELNCALPPPLHQTEAWLQEVEGLMDEDLSTSQDYSQDMTL
IQEKMTLFKSLMDRFEYHSTNLLTFENRDENHLPLVPPDKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLLDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKGFLAQLDTSFQ
KCEEI---YKN------LAGECQNISKQYMVMKSDVCTYRKNIDNVKSTLQKVLAYWATY
VENLCLLRACFEETKKEEIKE-----VPFETLAQWNLEHDTLNEAGNFLIEVSNDVVGSS
ISKELRRLNKRWRKFVSKTQLEMNLPL-I-KKQDQPTFDNSGN----------I-QLSEE
EKATVEFSTDLSIELPENYNQ--NIK----------------------------------
--------AGEEHEKENEESTGQLKVAKDVEKVIGQ------VEIWEAETKSVLDLLRDE
DDVN--TSVEESLKHLIAKGSMYEELMARTEDMLHMDIQNFSSQES---FQHVLTTGLQA
KIQA-AKEKVQINVVKLVAALKNSTDI-SPELDVRLKMEESQKELESYMTRAQQLLGQRE
SPGGLISKYKEALIISNTKSLAKYLKAVEELKKNVTEDIKMSLEEKSRDICATWESLHHE
LSLYVQQLKIDIEKGKLSDSILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEACLY
QLNHHMEVLRELSEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIYTTL-----QA
TAG-GT--SRNEGTITTSENRGGDSHSEVLFAKSDNQPSAEK---A-MKPVMNFSLASEL
KPRQEESMM---EKDYSASINSLLERYDTYRDNLEHHLQNSEFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VLKNETDACWKEFEIISLKSENLANDIKKP-FIVKERDRLKERERELQMTL
NTRMQSLETALQLVLPVEKTSLLLCGSD-LPLRKMAIQEFGLINADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
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----------------------------------DSIGKQTEICNRL-EEPGNFVLKELH
PCDLRAMQNIILKYKTQFEEMNRRVQRSEDTLRALEGFLESLKTAKLSTEPV-IDLSASE
TQVAQENTLTVKNTEGDIHLMKDKAKHLDKRLKMLDMSFKDAEQGEDTSCENLVDALLVQ
LSETHGYRVQEEFTEENTLLEA-------CIFKNNELLKNIQDVQSQVSKIGLKDPTVPA
VKHRKRSLIRLDKDLDEYEEEKKHLQEMANSLPHCKDGREKAVSQRCQSTILLWENTKAF
ITECLEQCGRVLELLKQYQNFKGILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYESLG
RALALWDKLFNLKNVIDEWMEKALQKMELHQLTEEDRERLKEELQVHEQKASEFSQRVAE
IQFLLQSSEIPLELQVMESSILSKMEHVQKCLTGESSNYALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESIS
DLFNTKKSLLQDHFSKLLNDQCKSFNDWFGNIKMNLKECFESPETKRSVEQKLQKLSDFL
TLEGRNSKIQQVDSVLKHVKKHLPKAHVKELSSWLVGQEFELEKMESICQARAKELEDYL
EHLLRLQDDHRNLSKWLSNQEEKWKGMEESGEKTELFCHALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMEATCLMDRYQTLLRQLSEIQEEDKLPPMEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEALM
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFISFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSAGQKI-IKDDIKSLKY-KQKDLENR
LESAKQEMEYCLNSIL-KSKCSSKK----KEKF-PLPGREKQATSDVRESTQESAAMEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVETVMSKQLSLSVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIKELYTQLEAKKAALEPLEQTECLNKTETGALGLHSVGYLAQHLDTL
LQALITLKKNKESQYCLLRDFQEHLAAVESSMKASLTDKESLKV-GPLDSVTYLDKIKKF
IASVEKEKDSLGNLKLKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQRKYSQQVV
EYGEFTSLMNKIRDTEIFL-Q---QQQQHLQLRLKSPEEQAGNQSVIALTTDLQAAKHGF
SILKGQAEFQMKRIWGEKEKKILDDGINNLKKQWETL-EPLNLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILDRQQSVESLAEEVKDKV
PSLTACEGSDLNSTLEDLRDQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMAQES
ETLITPKVETTA-TEAELKHHHVTLKASQKELQEIDKVISTYLQELTNIYEELNVFERLF
LDDQLKNLKNRTNRTQRFIQNKCNEVEHKINFCREFHEKSLALQEEVDS--IQHNELL-L
NQ----EVNTGVKEDIYNLKDRLTAIKCSILQVLKLKKVFDFIGVNWDFSQLD---QLQT
QAFEKERELAEKIKQLDTFEEEHGKYQALLSEMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQMLSQRIEKAKCLCEEIIKKLNDSKAFDDSFKEKEMLQIKLNAEENDKLYRVL-QNM
VLYLPPKEMDEKNFQDKLETSFHVLNQIKSQLQQPLLISLEIKHIQNEKDNCKVFQEQVW
AEVCSIRAVAVTEKQRE-ENSS-EASDVETKLRDFEDLQMQLTTSVDLRINVLNNAYENL
TRYKEAVTRAVESITSLEAVVVHYRMDTGNPEESLAVPLRK-QEELESTIADIQDLTEKL
GMISSPETKLQLQCTLQELVSKNSAMKEAVRVQETEAE--RYL------ENYKCCRKIEE
DIYTNLSKIETVLGQSMSLLPLSYREALEHLEQSKALVSNLVSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWVKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNVQ
EELPEISKTKEDATTEELSELLDCLCQYGENVEKQRLLLTLLLQRIRSIQNVPEGSGAVE
T-VPAFQEITSMQERCNQLLQKAQKNKGLVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MALQDHTEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPTYAMKRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSRLLANPADYDSSKTLSHHASTLQMA-LEDSEQKHNLLHSILMD
LEDLSIIVKTDELTQ-SIQELSNQVTALQQKIMENLPQIQQMADDVVAIESEVKSMEKRV
SKIKTILL-SKEMLDFSPEEHLKHGE----------------------------------
-VILENICPMKKTIAEIVSYQVGLRLPQTGMKPLPVFQRTNQLLHNIKLLENVTQEQNEL
LKV-VIKQTNEYDEEIENLKRILNNHSAQFSFEHMSPDQAAKLPQLQG-EIEGMEKQILS
LNQKKEDLLVDLKSTVLNLHQHLKQEQEKVE--RDVLPAVAS-EEGRAAER-DASEWKL-
--NRRDSMSYLAAVEEEAEESSVKSKNGDEKAELPPQS--WSSFWKHDKDV-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSPNTE---QGSECSLRTKQIEEGTTPPIK
VATLDFSDTQG-GLEHRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLEACKDQGLGDNGATQYEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKR--SEPEYQKVRQPVNLPELESTVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKAT-TQESSA----------SNQ
ASSPENDVPDLMLSPQGQ-NGDKWQY-----L-HHELSSKMKLPLP-QLVEPQVSTKMSI
LPSVSMYNFRYPTTEELQTYTTQLEDLRQEASDLQTQENMTEEMYVNLDKKLFELFLTLR
QCLSSVEEVLQMAELYREDGSAQQAHY----ETLALELKKLYLALSDKKEDLLKAMTWPG
RNTNLLLECFDNLQVCLEHAQAAAASRSKSLKAGLDYNRSFQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAHTVELENSESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGILRARYAELSGPFVTESQQDALLQGVVQLVKIGKEKLAHDHLKQTKSKGALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILLSTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLVKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSMHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQVLNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GGMPLLEDTASR
IDGLFQKRSSVITQVNQLKISMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVEKLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCRDTH--KR
WTQVNQ---AIADQLQKAQSLLQLWKAYSNAHGEAAARLKQHEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSTVLDRLPQ-PAESSTHMLLPSPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLL-MHEEENLDRLHQQEK--E-NPDSFLN
HLLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLCCCEKWTQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKSDIDGLVRQWQDFT-TSVE-D
LLRFLTDTSHLLSAVKGQEHFSLNQTRSLIHELKNKKIHFQRWRTTYAVTLEAGEKLLL-
-RTNLETKESVGRKISQLQDNWNNTEPPLAEMIHQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEKSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCFRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLMKASNTSRAAEIDDRLNKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTGAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSRAPGLEDEKEASENETDMED--PREIQTDSWHKSGESEE----
PSSPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQTEGVGNVPPVPAESSTPYNPPYGKLLLPPGT-
DGGKED---PRVLNGSPQP-GD-GRLAGITA-QQ--SGAFDRWELIQAQELHNKLKIKQN
L---QQLNSDISTITTWLKKTKA-ELEMLKMAKPPSDIQEIELRVKRLKEILKAFDTYKA
LVVSVNMSSKEFLQTESAESTE--LQSRLRQLSLLWEATQGMVDSCRGSLRQSLMQCQDF
HHLSQNLLLWLASAENRRQKAH-V-AHPKADPQALLECQRELVQLEKELVECQPQVDLLQ
EISNSLLIKGHGEEYIEAEEKVHVIDKKLKQLREQVSQDLISLQGTQNPDS-PLPG----
--FD--KVD-TGD-QPLSASMPAPRT-KFRG-----ERTTEGEEET-----------ESR
VAG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

--------------------------------------------------QREFTQKKTF
TSWINSILAKHTPPYVVSDLYTDIQQGHLLLDVLEVLSGQHLPREKGFNTFQCRSNIENA
LTFLKSRS------LKLINIHVADIIEGKPSIVLGLIWTIIFH FHIE----ELARTLACT
YNQ-----PSPDCPSAVD---SSPKANRSAKKSAK--IKERWKMSAT KALLLWAKEQCSL
-HGSV-SVTDFKSSWRSGLAFLAIIQTLRPGLVDLEKAKARSNKENLREAFRIAELELNI
PRLLEPEDVDTVNPDEKSIMTYVAQFLQYSKNLPESEEDMQE-KVREAV--------GWL
AEQEKKLAKLLVETEDETYCQKYKE----MMSFMETFNQEKIPFLPVLSSKRGEAELSEG
QQQMREEWDKVISQMNEWKVKLDQMLPSPLGSIEAWLQEVERLQAEDLPDLQDPFKAMSV
FREIIVIFKGLMECFDSHLDTLQSFKNEDEKNMPLVLPEKLEEMK-RRF-GNIRSTNPST
FLEYHYGLCSA--IANEVKLKLNIWDVKYGAKESVESLLENW------------------
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-

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-------DVDVVNPDEKSIMTYVAQFLQYSKDAAEARDKAQG-KIKDAV--------VWL
TLQEQKLREVLKDSENETYSKKYES----LLSFLESFNEEKKPFLDILPIRRNLDELNED
QLQLREAWDGLIYQINVWKTELNHALPSPLRQIEAWLQEVEELIDEGLPASQDYCEAMAL
IQEKMTLIKNLMDKCDCHWNTLLAFENRDEQHLPLVPPKKLEEMK-GRI-NNILGKKFIP
RLEFHYYKCSVLGLLDEVKLKLDVWNIKYGNKESVELLLEDWHKFIEEKEFLAQLETSFQ
RCEEI---HKN------LAGEYQDISKEYTMVEYNICMYRKNIYTVKSTLQKVLTCWATY
VEKLRLLKACFEETKKEQIKE-----VPFETLSQWNVEHTTLNEVGNFLIQVSTDEVESS
VSKELRRLNKRWRKFITKTQLEMNLPL-I-KKQDQPNFDNYEN----------I-QLSKE
GKPTVDFSTAMSVEHPENHNQ--NIK----------------------------------
--------AGEEHEKEN-EFTGQLKMAEEVENLIGQ------MEIWEAETESLLELLRRE
EGVD--ASMEEALQHLIAKGSMYEELVSRTEDTLQMDIQNISSQES---LHHVLTVGLQA
KIQE-AKEKVQINMIKLVAVLKNSADD-SPNLDVRLKVEESQKELDSYMTRAEQLLGQRE
SPSGLISKYKEALIILNSKSLVKYLKAVEELKNTVSEDIKLSLEDKSRGVCAKWESLHHE
MSLYIQQLKIDIEKEKLSDNISKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLNHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIRMTL-----QP
TMG-GS--SKNKETTNTSENGGRGVRSEVPSAESQGRPSTEK---A-MGSIKNFNLESKL
KPQQEESSMQKYEKDQNAALSSLQERYDTHRENLELYLENNKFRIISDFSGDEERSSACL
QDKLADLQ-VLKNETDACWKEFEITSLKLEELDSDIKKP-FISNMRDRLKEKEREFQMTL
NTRMESLETALKIVLPVEKESLLLCGSD-LLLHEIAIQEFHLIEADGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNNL-EQSGDSAFKELH
PLDLHAAQSIVLKHRTQLEEANHRVQRSKDALRALEEFLASLRTAELSFELV-TDLSASD
TQVVRENTVTVEDKEREISLMKDQARHLDKRLKMLGISLNDAEQGDD-TCDKLLVALSRK
LFETRGCGGQEELTEENKLLET-------CIFKNNELLKNIQDVYDQISKISLKDPTVPA
VKQRKKSLMRLDKDLDECEEEKKCLQEMVNSLPQFEDGREKPLNQQFQNTALLWESTKAS
VTECLDQCERVLELLKQYQNFKGVLTALIQKEENVISLQASYMGKENLKKRIAEIEIVKE
EFSEHLEVVDKINQICRNLQFHLNKMRIFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKVLRKMELNQLAEEEREELKEELQTHEQKSSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIEKVKTQLIGESICSALSGNTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMMLLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNITMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRGSKIQQVGTALNHVKKHLPKAHVKELNSWIINQEIELEKMESVCQARAKELNDCL
QELLRLQDDHRNLSKWLTSQEEKWKEMEKSGEKTELFCEAVARKREQFESLAQLNSSLKE
YGL-AEE----EEIIVESTHLIDRYQTFLRQLCEIDEEDKLPPTEDQSFNDLARDVIHWI
AGIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIQDIMGQAE------SSKAPL
A--PKTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGSYLLECTKNPNFSERPWLEIKH
LHESLLQQLQDSVEKLEGHVQEHHSYQLCVTDLNAALDDISKEFASFSDKPVDQTAVEEK
L-QKLQELENRLRLQDGTLKKILALAKSIKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAVQETENCLNSIL-KSKRSTEQ----KEKF-TLPGREEEVTSDGQEPTQDSTALEKF
EEDRDTNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEVVLSKQLSLDIQESMKNIEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELYAQLEAKKTAIEPLEQTEYLHKAETSALALHDTGHSGQHLDDL
LQALITLKKNKESQYYLLNDFQEHLASVESSVKALLTEKESLKV-GPLDSATYLDKIKKF
LASVEKEKASLSKMKIEWENLSNCLTDMDKKLLESQIKQLAHSWEQVKQLAQKKYSQQAE
EHEELTLLMRKIQDLDISL-Q---QQQQALRLGLNSPEEEEGSARVVAVGTELQTIKHRF
SAVKGQAEFQMKRIWGEKEKNALEDAMDNLQKQLEAL-EPLNIQVE-----NQIKKGEIR
NKMKEITLWVKNLLGELTPTISLLPDNILSQIRKCKVTHDGILDKQQVVESLVEEVKNNI
PNLKADENDDLNHLLQDLQSQYQMLVLKSTERSQQLEFKLEERNRFIAVIEKVQLLLQEN
EALITPEMRAAS-TETELEQERVALMSSQKELLEAQGVIAAHLQEQTNVCKDLSVFERLF
LDDQLKNLKTRANRTQRFIQNKCNGVEHKIRFFREFHEKAAALQKEVDH--IQHSDLL-L
NQ----EINEDVKEELYSLKDRITGIQSSILQALKLKELFDSVGLNWDCSQLD---QLQI
LVAEKEKELKEKIRQVDIFVAEHGKYQESLSKLKAMDLQIKKRAEGVLGVPHTSP-ESGL
LSAHILEWRIEKAMCLCQEIIKKLNESKAFDDSFKEKEILQIKLYAEENDKLHKIL-QNG
VLKSQPKEMDEKNLQEKLENSLRVLNQIKSQLEQPLLINLDIEHIQKEKENCEAFHEQVQ
VEMDSMKAVTLMEKQRE-ENSS-DPSDVGTKLRDIEDLHVQLNTSIDLRIDVLNDAYESM
TRYNEAVTRAMGIFTAREAIVASHKIDLDNPEEPLETPGWK-QEELQSTIADIQDLTEKL
GTISSPEAKQQLQCTLQELVSKDSAIRGAAKVKESEIE--RCL------ENYKCYRKIKE
KICANLSQMEAALGQSMFPLPASYKEALERLEQSKALGSNLLSNKEELMKLRQVLRHLRP
ACTESDDTCLLRTTAALWDKWLSLLEAAKEWEIWCEELKWEWKFVSEEIEREAIILDNLQ
EDLPEISKTKEAATTEELCELQDSLCRYQENVEKQQLLLTLLLHRMRSIQNAPKSLEAIE
T-IPAFQEITSMQERCNKLFQKAQENKELMEKEIQERHSFTKEIITLKNLFQQTATSFQN
MDLQDHPEKAEQFEELQSIFKKGKLTFENIMEKLRIKYSEMYTLVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYTMSRKIDEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWRSRLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYHDVLRSTEAWVQNTSRLLANPADYDSSKALSQHASTLQMA-LEDSEQKHNLLHSIFTD
LEDLSIIFETDDLAQ-SVQELSHQVAALQQKIMESLPQIQQVADDVVAVETEVKSIEKKV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKAIAELMSYQVELRWPQTGMKHLPAFQQTNQLLQDVKLLERVTQEQNEL
LKI-VIKQTDECNEDIENLKHILNNYSAEFSHECLSPDQAANLTQVQG-EVEGMEKQILS
LKRKKENLLVDLKAAILALHQHVQQGQQAFE--PEMPSARAA-AEEGEAER-DS-QWKG-
--NRTGGLSFLPALTEEAEESSLKSENGDKKAEPSSGS--WSSLWKPDRDV-EEDRA-SS
SSGTIIQE----AAEKISICDNPMAQILAPD-------------SLSPSQTEEGATPPLK
AAAPGFSDEQG-AFEATV--EKSRPKPAEILHACKTQVAELELWLRQASVAFEPETLNAD
MQQLVEQQLVGCQAMLTEIEHKVASLLESCKDRGPGDSGATQQEAEALSMKLKTVKCNLE
KVQIMLQEKYSEDQ--HSATLKKP--S--ERQNDLQPDNPSALESGVTERPQFSRHKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKNMWPQHCQSDKDT-TQKSSE----------SSR
ASSPENNAPDSVLWTQGQ-SGDKWQY-----L-HHELSAGFGLPLP-EQVQPQVATNMSV
LPSVSVYNFRYPTTEELRTYTTQLEDLRQEARNL-TQENMTEETYVNLDKKLFELFLTLS
QCLGSVGEMLQTPGLFREDVCAQQVHC----ETLALELKKLYLAMGDKKNDLVKAMTWPG
RSTSLFPECFDNLQVYLEHTQATAASKSKSLKAGLDYNRSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIDEQLQKADAYTVELQNSESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGILRARYAELSSPFITESQQDALLRGMAELVDIGKEKLAHDHLKQTKSKAALQAQIQ
NHKVFFQKLVADMLLIQTYSNKMLPSLLQKRETFWAEQIKEVKLLEEKSHQHGIKLQSLL
QKWEEFDENYTSLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLALNKKIDHELHRLQTLLKHLV------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKELDDKSSLKAAVVGT
GSQLLHLKAADTATLRASLAQLEQKWTMLITQLPDIQEKLH Q LQMEKLPSRKAITEMISW
MNDVEHQTADEDTEHSLSSASQVRNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTLQKPGSVISVQKMLLDCQDIENQLAIKSKALDELRQSYLTLES-GTMPLLEDTASR
IDGLFQKRSSVISQVNELKTSMHSVLQEWKVYDKLYEEVTMMTIRFWYCMEHSKPVV--L
SLEALRCQVQNLQSLQDEAENSEESWEKLQEVIGKLKDRC-PSVAEIIKEKCQETH--AR
WTQVNQ---DLADQLQKAQSLLQLWKAYNSAHMEAAARLEQQEAKYQQIENINMSGNNLA
EILTPALQDVK-ELQHDVQKTKEDLLQNSTLLDRLPQ-LPEASTHVPLSKQLHSLQRASY
LEKMLLMKANEFEFVLSQFKDFGDQLESLKGLI-VHEEENLDKLNHQEK--EENPDLFLH
HVLAMTAQSPDVEHLNEVSLKLPLSDIAVKTLQNVNRRWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWVQLLEKIEETLKVNVADSLPALLEQQKTYEMLEAEVSINQTIADSYVT
QCLQLLDTTEVEKRPAFISKFTKLKDQWQSAAQSIRQRKGDIDGLVGQWRYFT-TSVE-D
LLRFLTDTCHLLSAVKSQDCYSLQQTRRLLRELKSKEIHFQRRQTTFELTLEAGEKLLN-
-TANLETKELIDKKISQLRDKWKDRKLQVGEMIKQLQSNV-ETWDQCEKKIKELKSRLQV
LKAQSRDPLPELHEDLHKEKELMKELEKSLGNWTKNLKELHTMKTDLTQHILVEDVMVLE
EQTEHLHRQWEDLCLRVAVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LRLKQMGDQLIKASNKTRAAEIEDKLNKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARE---DTAS
RLKQMVHEGNQRWDTLQRRVTAVLRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHRRLT SHAPGLEEEKEASENETDMED--PREIRADSWRKRRESEE----
PSSPQSLC----HLVPPVP----GPERSGCE--TPVSVESIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSAL-----------------------SGKSLPEDHS------
------------WHVPDSPSCPKHRYKQMGGDRNVQTIPSDSSTPYKPAYVKLLLPPGT-
DGGKEG---SRVSNGSSRH-ED-KGLAALSG-QQ--SGAFDRWELIQAQELHNQLRIK QS
L---QQLNSEITDITSWLKEMEA-ELEMLKTAEPPSDIREMELRVKRLKEILKAFDTYKA
LVVSVNMSSKDFLQTESAESSK--LQGRVSQLGLRWDTAQDAVESWKEGLR QSL LQCQDF
HKLSQDLLLWLASAESRRQKAQ-V-TDPDADPQVLLECQEELMQLERELVERQPQVNTLQ
EISDSLLIKGHGEDYIEAEEKVHVIEKKLRQLLEQVSQDLVSLQGRQNPDP-SLPS----
--LD--EAD-AGD-QPPAASVPTPQAKQFEA----ERMTRDKHKTD-------SRVP---
SPG-SSRPRRSFMSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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---S-ISVTDFKSSWRSGLPFLAIINALRPGLVDLEKAKARSNKENLDEAFRIAELELNI
PRLLEPEDIDITNPDEKSIMTYVAQFLQYSRNMPET-EDMQV-C----------------
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-

-------MASSPVLPTEDQ-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVVTDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIENA
LTFLKNQS------IKLINIHVTDIIDGNPSIILGLIWTIILH FHIE----ELARTLPGN
YSQ-----PSLDSVSAV-D--SSPTSSPPAKKCSK--VQERWRVSAKKALLQWAQEQC AS
-YES-VTVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKHRSNRDNLKEAFRIAERELKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLQYSKKAPGSGDEAQG-KVKDAM--------VWL
ALQEKKVQKMLADSENETYCKTYES----LLSFLESFNKEKERFLDVLTIKRNVDDLNKD
QLQLREAWDGLNYQINVWQTELNHVLPSPLYQIETWLQEVEKLIDEDLSVSQDYNEAMAL
TQGKITLFQSLMDKFDFHLNTLLAFENRDENHLPLVPPEKLEEMK-RRI-NNISGEKVIP
RLEFHYYECSVLGLLEEVKSKLLVWNIKYGNKESVELLLEDWHKFIEEKEFLAQLETSFQ
KWEEI---HNN------LAGEYPNISKQYTMVKYHFSMYRENILNVKSTLQKVLACWATY
VENLRLLKACFEETKKEQIKE-----VPFETLSQWNLQHTTLNEVGNFLFQVSNDEVGSS
ISKELRRLNKRWRKFITKPHPEVNLPL-M-KLQDEPFLDNSGN----------I-QPSKE
ENLTVGFSTNTSSELPENHNQ--NIM----------------------------------
--------AGEDHEKENEDFSGPLKVAEEVEKLTGQ------VETWEAETTSVLDLLRQQ
DDVE--TSVEESLQHLIAKGSMYEELVSRIEDTLQMDVPHVSSQES---LQHVLTAGLQA
KIQE-AKEKVQISMVKLVAVLKNSTDV-SRDLDVRLKVEETQKELESYITRAEQLLGQKE
SQRGLISKYKEALIIFNTKSLAKYLKAVEELKNNVTDDVKLSLEEKSRDICAKWESVHHE
MSLYIQQLKIDIEKGKLSDSIAKLEKQISKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIHMTL-----QP
TLG-GT--SKNKGNTDASENGGGNTLSEVPSAKSDNQPSAEK---A-MELVQNFNLESKL
KPQQEESIMEKYEKGHSTSIDSLLERYDTHKDTLELHLQNSIARITSDFSSDKERSSVCL
QDKLTDLQ-VLKNETDACWKEFEITSLKLEELESDIKKP-FIVKARDKLKEKERELQMTL
KSRMESLETVLQMVLPVEKESLLLCDTD-LLLCKLAIQEFHLTDADDIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIVKQIETCKNL-GQSGNFALKELY
PLDLHVAQNIILKHRTQLEEMSHRVQKNKDALEALEDFLASLRAAGLSSELL-TDHSASD
SHGVPANTLTVEDKKREIHRMRDKARHLDERLKMLGISIKDTEQGENTSCEKLLDALSEN
LSETHCSGGQEEVTEEDKLLGA-------CVFKNDELLKNIQDVHNQISKIGLKDPTVPA
IKQRRKSLIRLDKDLDEYEEEKKHLQEMVNSLPPFKDGRDKALSQRCRDTAVLWENAKTL
VTECLDQCERVLELLKQYQNFKSVLTTLIQKEENVISLQASYMGKENLKKRIAEIEVVKE
EFNEHLEVVDRINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFYLKNEIDEWTEKVLQKLELHQLTEEETKKLKEELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIEHVKMRLTGGSNCGAISGSTAELREDLDQAKTQIG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHNMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGSIKMNLKECFEPSETKKCVEQKLQKLSDFL
TLEGRGSEIQQVGTVLNHVKKHLPKAPVKKLNSWIVSQEVELEKMESICQARAKELDECL
QQLLRLQNDHRNLSKWLTNQEEIWKEMEGTREKTELFCQALARKREQFESMAQLNNSVKQ
YGI-TEE----EEIVTESTHLVDRYQTLLRQICETDKEDKLLPDEDQSFNDLAHDVIHWI
TGIKESLMVLNSSEGKMPLEERIHKIKEIILLKPEGDAKIQAIMSQAE------SSKAPV
V--PKTLTDIKNQWDNTLHLANTYLSYQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQPGLQEKKAQLKIYKKFLQKAQDLTFLLEELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHDSYQLCVTDLNTALDCIAKEFVCFSDRPVDERAVEEK
L-QKLQDLENSLHLQDGTLEKILTLAKSVKQNTSSAGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMENCLNSIL-KSKCSTEK----KAKF-PLPGREEQVTSDVQESTQDSAVVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSALEMILSRQLSLDVQESMKNTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELCTLLEGKKAAIEPLEQSEYLNKTETSALVLHDESYSVQHLDNL
LQALITLKKKKESQYCLLKDFQGHLMAAESSMKALLTEKESLKV-GLLDSATYMDKIKNF
LASIEKEKDSLSKMKIEWENLSNCLTDMDKKLLESQIKLLEHGWEQVEHLVQKKYSQQSV
GHDEFMFLMSKIQDLETSLQQ---QQQQHLQLRLKSPEAQEGNLSMVALATELHTIKHRF
SMLKGRAELQMKRIWGEKERKILEDAISNLQKQLEAL-EPLNMEVE-----NQIRKCETR
YKIKEAILWVKNLLGELTPPVSLLPDDVLSQIRKCKVVHDGILDKQQVVESLVEEVKDNI
PNLTAYESNDLNNLLQDLQNQYQMLVLKSTQRSQQLELKLEERSKFVAIIGKVQLSLQGN
ETLIIPKTETAS-TEAELEQLYVALTTSQKELQEIKSVISTHLQEQTSLSKDLSVFERLF
LDDRLKNLKTRANRTQRFIQNKCNEVEHKINFYREFHEKISALQKEFDH--IQHNELL-L
NP----EVNPDVKEELYHLKNQITGIQSSILQVLKLKEVFDCLELKWDWTQLD---QIQT
QVLEKERELEEKIKQLNTFVAEYDKYQASLAKLKALDLQIKKRAEPVLTMPNTPP-ESSL
LNAQILNQRI------------------DFDDLFKEREIQQLKLHAEENNKLRQVLQQKV
ALQSQLKEMDEKDFEDKLENSLHVLNQIKSQLQQPLLMNLQIESIQNEKDNCEVFQEQVQ
AEMDSIKAVTVIEKQSE-ENSS-EASDVEAKLNDIEDLYMQLNASIDSRTNVLNDAYENM
TRYNEAVSRATEIISNLEAIIASQRVDLDNPEESVEVPRRK-QEELKSTIAGIQDLTENL
GTISSLEAKRQLERTFQDLVSKHSALREAAKGKEAEVE--RCL------DNYKCYRNINE
KICTNLSQMETILGQSMCPLPVSYKEALERLEQSKAFVSNLVSTKGELIKQRQVLRHLRA
TCTDSDSLYLLRSTSALWERWLNLLEAAKEWEMWCEELKQEWKFVHEEIEREVIILDILQ
EELPEISKAKEAASTEELLGLLDCLRQYEENVEQQQLLLALLLQRIKNIQNTPEGVGAVE
S-VPASQEIMSMQERCHKLFQKARKNKELMQNEIQERHSFTKEITTLKNLFQQTTISFQN
MELQDCPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRNAL
EDVDEKISNEVLKSSPSYTMSKKIDEINNGLRNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDKLMIPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWIENTSHLLADPSDYDSSKTLSHHASTLQMA-LEDSEQKHTLLHSVFTD
LEDLSAIFETDDLAQ-SIQELSHQVAALQQRITENLPQIQRMADDVVAIETEVKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNRLLQDIKLLENVTQEQNEL
LKI-VIKQTNECNEEIEKLKQILNNYPAEFSHEHMSTDPAANLSQVQG-EIEDMEKQILS
LNQKKEDLLVDLKAAILNLHQHLQQKQQELE--QEVVSVGAS-EENAGAEK-DASEWKL-
--NRTGSVSFLPALEEEAEESSLKSESGDKKAEPSSGF--PSLLWKYDKDV-EEDRA-SS
SSGTIIQE----AAGKISTCDSSMAQVLEPDLLNTE---QGPEFSLSPNQTPEGATPPIK
AAATGLSDKQG-AFEATV--EKVRPEPAQVLHVCKNQVAELELWLHQANVAFEPETLDAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--HSTTLKKS--S--ERQKVLQPDNLSEFESVVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-ANKTWPQYCQHDKDT-TQTSSA---------RSSK
TSSPKNDAPDLIWSTQGQ-SGDKWQY-----L-HHELSSKIRLPLS-QLVQPQVTTNTSV
LPSVTVYNFRYPTTEELKTYTTQLEDLRQEANNLQAQENMSEETYTNLDKKLFELFQTLV
QCLGSVEEMLQTPGLFRGDVGTQQVHY----ETLALELKKLYLAMSDKKNDLSKAMTQPG
KNASQFLDCFDNLQVYLEHTQARAASRSKALKAGLDYTRSYQNEIKRLYDQLVKNKTSLQ
QSLNEISGQTIDEQLQKMDAYIVELQNSESRVAKLREEGERLHLPYVLLQEVYKLEDVLD
STWGLLRARYTELSCPFITERQQDALLQGMVELVHIGKEKLAHDHLQQTKSKVALQAQIQ
NHKLFFQKLIADMLLIQAYSNKMLPSLMQKKETFGAEQVKEVKLLEEKSHQYGIKLQSLL
QKWEEFDENYASLEKDLEILMSTLPSVSLVEETEERLVERISYYQQIKRNMDEKHARLYQ
TLNEGKQLVASVNCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSRKAIMEMIDW
MNNVEHQTEDEDSEHSLSSASQVKNLLQKYKELRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGALNGKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTLQKPESVISVQKTLLDCQDIENQLAIKSKALDELRQNYLTLES-GTVPLLEDTASK
IDELFQKRNNVMNQVNELKTSMQSVLQEWKIYDKLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVQNLQTLQDEAESSEGSWKKLQEVIGKLKEYC-PSVAEIIQEKCQNTH--TR
WTQVNQ---DIADQLQRAQSLLQLWQACNSAHAEAAARLEPQERKYQQIANINTSGNNLA
EVLPPALQDAK-ELQCEVQKTKEAFLQNSALLDRLPQ-PAEPNTHVLLSGQMHSLQRASY
LEKMLLVKTNEFEFVLSQFKDFGDRLESLKGLI-THEEENLDKLYRQEK--EGNPDLFLN
HVLALTAQSPGIEHLNEVSLKLPLSDVAMKTLQNLNRQWIRATATAL-ERCSELQEIGLN
-EK-FLDCCEKWIQLLEKIEETLKANMADSLPALLEQQKTYEMLEAEVSINQTIADSYVT
QCLQLLDTVEIEKRPEFVWKFTRLKEQWQSAAQGVRQRKSDVDELVRQWRSFT-TSEG-D
LLRFLADTSHLLSAVKSQDCHSLHRTRSLIHELKNKEIHFQRWHTTYALTLEAGEKLLN-
-TANLETKESVNKRISQLQDNWKDTKLQLGEMIKRFQSTA-ETWDQCEKKIKELKNKLHA
LKAQSKDPLPELHEELHREKELIKELEKSLANWTQNLKELHTMKTDLTQHILVDDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDRLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMNADAWGRGWKW---DRSRDKKLYE
SSDWTAACPNSSEVLYTVAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDVED--PREIRDDSWRKRAASEE----
PSSPQSLC----QLVPPAL----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAL-----------------------SGKSISEGPS------
------------WHVPDSPSCPKRRYKQMGGDRSVQPIPSDSSTPYKPAYVKLLLSPGT-
EGGKED---PGILTGGAQQ-ED-EDLAALTG-QQ--PGAFDRWELIQAQELHNKLRKKQS
L---QKLNSDISNITPWLEKTGA-ELETLKLAEPPSDMQEMELQVKKLKEILKAFDTYKA
LVVSVNVNSKEFLQSESAESRE--LQDRVSQLTLRWNTALGAVESWREGLRQSLMQCQDF
HQLSQSLLLWLASAESRRQKAH-V-TDPEADPQVLLACQEELMQLEKELVEHQPQVNSLQ
EISSTLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLVSLQRSQNPDS-PLPS----
--VD--EVD-HGE--PLAASAPAPQAKQLEA----EKTTKEKNKPT-------SRVPDPA
APE-SSKPQRSFLSRVIRAALPLQLLLLLLLFLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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------------------------------------GKEKLVQDYLQQTKSKLALQAQIQ
NHKGFFQKLVADMLLIQTYSAKMFPSLLQKRETFWAEQVAEVKLLEERSQQCGMKLQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIHGKHARLCQ
TLNEGKQLVASVSCPELEGQIAQLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTVVIST
GNQLLHLKEADTATLRASSAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSREAITEMISW
MNSVEQQTAD--SVCSPGSVSQVKNLLQKHKAVRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGALTRKIQHLEQLLESITENENKIQILNNWLEAQEE
RLKTLQKPESVVSVQKLLLDCQDIENQLAIKSRALDELRQSYLSLES-GTMPLLEDMASR
IDELFQKRSSVIIQVNQLKTSMQPVLQEWKIYDKLYDEVSMMTIRFCYCVEHSKPVV--L
SLEAVRCQVQSLQSLQDDAESSEGSWGKLQEVIGKLKGLC-PCVAEIIKEKCQVIH--AR
WTQVNQ---DIADRLQKAQSLLQLWEAYNTAHSEARARLEQQEAKSQQLANINMSGNNLA
EILPPALQDTK-ELQHDVQKTKESFLQNSPLLEQLPQ-PTESGTHMFLPGHLHFLQRATH
LEKMLLMKANEFEFVLSQFKDFGDQLESLKDLI-RHEEENLDRLYQQEK--EENPDSFLN
HVLALSAQSPAIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWVQLLEKTEETLKVNIAGSLPALLEQQKTYEMLEAELSINQTIADSYIT
QSLQLLDTTEIEKRPEFVSEFSKLADRWQSAAQGVRQRKGDIAGLVRQWRYFT-TSVE-D
LLRFLTDASHLLCAVEGQDRHSLYQIRSLIHELKNKEIHFQRWQTTYSLTLETGEKLLH-
-TTNLECKESVDKSIRQLRDQWNNTELQLAEMIKQFQSIA-ETWDQCEKKIKVLKSRLQV
LKAQSKDPLPELHEDLHNEKDLIKELEKSLANWTQNWKELETMKADLTQHILVEDVMVLK
EQIEHLHRQWEDLCLRVAVRKQEIEDRLNSWIIFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKTRAAEIDDKLNKINNRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDMED--PREIQTDSWRKR--SEE----
PTSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDSHS------
------------WHVADTPSCPKHHYKQMEGDRDVPPIPSDSSTPYKPPYVKLLLPS---
--GKES---PRVINGDPQQ-ED-EGLAGGNG-QQ--PGAFDRWELTQAQELQDKFRMKQN
L---EQLNSDISNITTWLEKTEA-ELEMLKMAKPPSDIQEMGLRVRRLQEILNAFDTYKA
LVVSANTSSKEFLQTPSAESRE--LHSRLRQLSLGWDAAQGAVDSWRDGL RQSLMQ CQDF
HQLSQNVLLWLASAENRRQKVH-V-ADPKADSQTLLERQKELRQLEKELMERQPQVDSLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVS QDLMSLQGTQNPDT-SLPG----
--LD--EVD-MGD-QPPATSAPVPNTKFQKL-----Q---EGD--L-------REIHSLR
VPG-GVRPR RSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWVNSQLARHSSPSVISDLFTDVKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVA-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQQQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAHGTGEEARG-KVNNAM--------VWL
TLQKEKLQKLLKDSENDTYFQKYNS----LLSFMESFNEEKKSFLDVLSIKRNRDELDKD
QLQLEEAWDGLNHQINAWTVKLNCALPPPLHQTEAWLQEVEGLMDEDLSTSQDYSQDTTL
IQEKMTLFKSLMDRFEYHSNNLLTFENRDENHLLLVPPDKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLLDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKGFLAQLDTSFQ
KCEEI---YKN------LAGECQNINKQYMVMKSDVCMYRKNIYNVKSTLQKVLAYWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHGTLNEAGNFLIEVSNDVVGSS
ISKELRRLNKRWRKFVSKTQLEMNLPL-I-KKQDQPTFDNSGN----------I-QLSEE
EKATVEFSTDLPIELPENYNQ--NIK----------------------------------
--------TGEEHEKENEESTGQLKVAKDVEKVIGQ------VEIWEAETKSVLDLLRDQ
VDAN--TSMEESLKHLIAKGSMYEELLARTEDMLYMDIQNFSSQES---FQHVLTAGLQA
KIQA-AKEKVQINVVKLVAALKNSTDV-SPELDVRLKMEESQKELESYMTRAQQLLGQRE
SPGGLISKYKEALIISNTESLAKYLKAVEELKNHVTEDIKMSLEEKRRDVCATWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKTQQEVKRLLKDYEQKIERLLKCASEIHTTL-----QA
TGG-GT--SRNEGTITTSENRGGDSHSEVLFAKSDNQPSAEK---A-IELVMNFSLASEL
KPPQEESIM---EKDYSASINSLLERYDTYRDHLEHHLQNGEFRVTSDFASEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENLANDIKKP-FIVKERDRLKERERELQMTL
NTRMQSLETARQLVLPVEKASLLLCGSD-LPLHKMAIQEFGLINADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------NSIAKQIETCNRL-EKPGNFILKELH
PCDRHAMQNVILKYKTQFEEMNRRVQRSEDTLRALEGFLESLKTAKLSAEPV-VDLSASD
TQVAQENTLTVKNTERDIHLMKDKAKHLDKRLKMLDMSFKDAEQGEDTSCENLVDALSVK
LSETHGYGVQEEFTEENTLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKDLDEYEEEKKHLQEMANSLPHCKDGREKAVSQQCQNTILLWENTKAF
ITECLEQCGRVLELLKQYQNFKAILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYESLG
RALALWDKLFNLKNVIDEWTEKTLQKMELHQLTEEDRERLKEELQVHEQKASEFSRRVAE
VQFLLQSSEIPLELQVMESSILSKLEHVQKCLTGESNNYALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNNQCKNFNDWFSNIKMNLKECFESSETKRSVEQKLQKLSDFL
TLEGRNSKIQQMDSVLKHVKKHLPKAHVKELSNWLAGQEFELGKMESICQARAKELKDYL
ERLLRLHDDHRNLSKWLTNQEEKWKGMEESGEKTELFCHALARKREQFESVAQLNNSLKE
YGF-TEE----EEIIMESTCLMDRYQALLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLADISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEAG
FALQHGLKEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHKSLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFNSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKIVALAKSIKQNTSSVGQKI-IKDDIKSLQY-KQKDLENR
LESAKQEMEYCLNSIL-KSKCSSEK----KEKF-TLPGREKQATSDAQESTQESAAMEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLSVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIKELYTQLEAKKAALEPLEQTECLNKTETGDLSLHNAGYSAQHLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASVEKEKDSLGNLKIKWENLSKHVTDMDKKLLENQIKQLEHGWEQVEQQIQKKYSQQVV
EYGEFTSLMSKIRDTEISL-Q---QQQQHLQLRLKSPEEQAGNQSMIALTTDLQAAKHGF
SILKGQAEFQMKRIWGEKEKKILEDEINNLKKQWEIL-EPLNLKAE-----NQIKKCDIR
NKMKETILWAKNLLGELIPSISLLPDDILLQIRKCKVTHDGILDRQQAVELLAEEVKDKV
PSLTTCESSDLNNTLEDLRNQYQMLVLKSAQRSQQLEFKLEERSNFFAIIRKFQLMAQES
ETLITPKVEATT-TEAELKHHHVTLKASQKELQEIDNVISTYLQELTNISEELNVFERLF
LDDQLKNLKNRTNRTQRFIQNKCNEVEYKVNFCREFHEKTLALQEEVDS--IQHNELL-L
NQ----EVNTGAKEEIYNLKDRLTAIKCSILQVLKLKKVFDFIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSEMRATDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCEEIIKKLNDNMAFDDSFKEKEILQIKLNAEENDKLYRVL-QNM
VLNLPPKEMDEKNFQDKLETSFHVLNQIKSQLQQPLLINLEIKHIQNEKDNCKAFQEQVW
AEVCSIRAVTAIEKQRE-ENSS-EASDVETKLRDFEDLQMQLTTSVDLRINALDDAYENL
TRYKDAVTRAVESITSLEAIVVHYRIDIGNPEESLEMPLRK-QEELESTIADIQDLTEKL
GMISSPEAKLELQCTLQELVSKNSAMKEALKVQETEAE--RYL------ENYKCCRKVEE
DICTNLSKIETVLGQSMSSLPLSYREALEHLEQSKALVSNLVSTKEELMKLRQILRLLRL
RCTENDGICLLKIMSALWEKWLSLLEAAKEWEMWCEELKQEWKFVNEEIEREAIILDNLQ
EELPEISKTKEAATAEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPEGSGAME
T-VPAFQEITSMQERCNKLLQKAQKYKELIQTEIQERRSFTKEIIALKNLFQQTTTSFQN
MAFQDHSEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLLIPFQQYQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSRLLANPADYDSSKTLSHHASTLKMA-LEDAEQKHNLLHSILMD
LEDLSIIVETDELTQ-SIQELSNQVTALQEKIMENLPQIQQMADDVVAIESEVKSMEKRV
SKIKTILL-SKEILDFSPEEHLKHGE----------------------------------
-VILENICPMKKTIAEIVSYQVGLRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQINECDEEIENLKQILNNHSAQLSFEHMSPDQAAKLPQLQE-EIEGMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEKVE--RDVLPAVAS-EEGRVAER-DASVWKL-
--NRRGSMSYLAAVEEEAEESSVKSQNGDEKAEPPPQS--WSSFWKHDKDV-EEDRA-SS
SSGTIVQE----ACGKISTCDNSMAQILAPDSPNTE---QGSECSLRTNQTEEGTTPPIK
VASLDSSDTQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNTD
MQQVVEQQLVGCQAMLTEIEHKVAFLLEACKDQGLGDNGATQYEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKR--SEPEHQKVRQPVNLSELESTVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKAT-TQESSA----------SNQ
ASSPENDVPDLILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMSI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASSLQTQENMTEETYVNLDKKLFELFLTLS
QCLSSVEEMLQMAGLYREDGSAQQVHY----ETLALELKKLYLALSDKKDDLLKAMTWPG
RNTNLLLECFDNLQVCLEHTQAAAASRSKSLKAGLDYNRSFQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAHTVELENSESRVAKLRDEGERLHLPYVLLQEVYKLEDILD
SMWGILRARYAELSSPFVTESQQDALLQGVVELVKIGKEKLACDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKILPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILLSTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLHEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLVKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSMHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GEMPLLEDTASR
IDGLFQKRSSVITQVNQLKISMQSVLQEWKIYDQLYDEVNMVTIRFWYCVEHSKPAV--L
SLEALKCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQDTH--KR
WTQVNQ---AIADQLQKAQSLCQLWKAYSSVHAEASARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSTVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFRDQLESLKGLL-MHEEENLDRLHQQEK--E-NPDSFLK
HVLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWTQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDSAEIENRPEFISEFSKLTDRWHNAVQDVRQRKSDIDGLVRQWQDFT-TSVE-D
LLRFLTDTSHLLSAVKGQEHFSLYQTRCLIHELKNKKIHFQRWRTTYALTLEAGEKLLL-
-TTNLETKESVGRRISQLQDNWNDTQPPLAEMIQQFQSTV-ETWDQCEKKIKELRSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEKSLASWTQNLKELQTMKTDLTRHVLVEDVMVLK
EQIEHLHKQWEDLCFRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSRAPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSSPKHHYKQTEGDGNVPPVPAESSTAYNPPYGKLLLPPGT-
DGGKED---PRVLNGSPQP-GD-GRLAGITA-QQ--SGAFDRWELIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTKA-ELEMLKMAKPPSDIREIELRVKRLKEILKAFDTYKA
LVVSVNMSSKEFLQTESAESTE--LQSRLRQLSLLWEATQGMVDSCRGGLRQSLMQCQDF
HHLSQNLLLWLASAENRRQKAH-V-THPKADPQALLECQRELMQLEKELVECQPQVDLLQ
EISNSLLIKGHGEEYIEAEEKVHVIEKKLKQLQEQVSQDLMSLQGTQNPDS-PPPG----
--FD--EVD-SGD-QPLSASVPAPRA-KFRG-----ERTAEGEEET-----------ESR
VAG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASMQSSPSTEE-QA-SSEIDDLHL-----SLQ---------VQRECTQKKTF
TTWINSILSKHTPPSVISDLYTDIQQGHMLLDLLEVLSGQHLPREKGFNTFQCRSNIENA
LTFLRSKS------LKLINIHVADIIEGKPSIVLGLIWTIIFHF HIE----ELARTLACT
YNQ-----PSLDCSSTVD---SSPKASRSAKKSAK--IKERWKI SATKALLLWAKDQCSL
-HGS-ISVTDFKSSWRSGLPFLAIINALRPGLVDLEKAKARSNKENLDEAFRIAELELNI
PRLLEPEDIDITNPDEKSIMTYVAQFLQYSRNMPET-EDMQG-KLTEAV--------SWL
AAQGKKLAKLLMDTENETHYQKYKE----MMSFMEAFNQEKKAFLPLLSSKRSEAELSEG
QQQMREEWSKLVTQINEWKAELDQMLPPPLDGIEAWLQEVEHLQAEDLPDLQDPFKAMSL
FREIIVIFKGLMDCFDSHLDTLQSFENKDEKNMLLVVPEKLEEMK-RRL-NNTCFTNSNT
LLEYHYGLCSA--IANEVMLKLNIWDIKYGTKESVESLLENWNNFVEEKRLETQLETATH
ICEDL---KI-------LAGDPQEITKLFKMVESKISMCRDYIANVNSTLQKVLSSWSNY
TENLHSLKTWLDEKRNEHPKE-----IPAEILASWNSVHGSLNEAGNYLIEVSKEQVGSN
IAKELKKLNRRWAKFIKRTHFDKTLYL-V-LEVDVLHILRACEPLLNCIIFA-S-AR-RK
LGLSVTFINATVAMINGGKKMQHLGE----------------------------------
--------ESTDTVEKARELPGSV---EKIEELLGG------VDSWAAEVGCLLGEIGHK
APVE--PQRKEYLQSLAARGTSCQEQVAAAEEILQSLMQNASDQVS---QQHSHTTGLQA
RVKE-ARDKIECKTRKVLDYWSQTPRL-LPEKEALLNFEESQIDLEASISKAVQLVSQKL
SPEEHISRYEEAFNALDNKVLDKFLKAAEQLKNISSDQEKLVVEEKSKDVRKRWEAVHHE
IMSYVQ-LMIEREKKKFNTTLKKINKQLGKEKKFLSMDKTKGLLKEHE--AFFSQEGSLR
ELSKSLEDLKILGRL-----AKETVPDIQAFIADCGQKLEKLQQVVSDTHTAL-----LS
RAGKRE--LSKKQDSIVASENGEEPGSSEKNDRLSVQETSIP---A-----AETDLETYV
EHHNGETCEKMFEEDSHLPSPDLLESYNTKRSNLEELLQISREKVASGFTDEI-KDTSCL
QNKLHELQ-VIENDTTSGWTQLGNISSTLENLVDEVERA-TLSETRSKLEGEWKELQDII
NTRTNSLRTALEIVLPIENESILLRELD-QRLNKKDIQQFNLMNSDLAYRELKE------
-LQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------RSILNQIEVCKQL-ENLDSSARDEFN
PIDLQAASKIMFYYQNQLEEMSHKMQIRETVLKDLEAFMASLRKIQSSIRRLTDSSGQPE
IQ----EKVLREAAQEVSHMAK-EAKCLDERLKAVDICLEDAECGGETWCEKLVLNLSEE
LTMTCGHSSDQMLTEENDLYKI-------FSTRNCELLKNIQDLRDRINKIGLKDPTIPA
IQQRVKSLTELEKELDCAAVEMKSMREITNKLLQMKEEKAEEANEQCRVTERLWEDTKLL
LAECQEQCARALELLKQYQSCKSSLTSIIQKLEIVLAQQNSYMGKENLNRLITKIEEAKE
EFHDHSEDVDKINQICKNLQFQLNKMRSFEEPPFENEANIIVDRWLDINEKTENYCDNLG
RAQALWDKLLNLSGTIDAWANAELKNIEDHCLTEEDLTQLKACLRVQEQKLQKFDNTVAE
IEELLNSNEPPLELQVIRSSVVQKMELIKDLLSMKQHTSELAVNTAELKGDLDLAKTQIG
MTESLLKALSPSDTLEIFTKLEEIHQKILQQKHHVTLLQEETDC--PDVDELNKQLKCVT
DLFNKKKDVFQDHFIGVLNRQCKNFNDWFSSTQLSLKDCFEPSETKQVLEERQQRLKHFL
TSDGKDRDIQEVKTLLNKVKHYLPKASINQLNSRVRDQEAELQRLISKCQKQEKELGASL
QQLSSLEESSIVLEERLITQEEKLQETEKDETKLEDLYKTLLMQREEFDSLAQLANSLKE
AGL-T-E----DGTILETSGLISRYHTLVTNVSEMVGNSEGQEVEGQHFEELAQDMSSCI
KRLEKAVNNLRSQESELPPDERSNQIKEITALKNAGDVKIQSMVALGETLMRNEKIKKPE
V--QQTISELKNQWESTCQLATEYRSPQEQLQLTREQYEQSKESLRLALNELKKEQEEMG
FALQPGLQEKQAQLTSYAHLLQKAEDLTSQFNELESQ-DHLQSCTENPYFTEESWLELKH
QHENLLSQLQTTVQTLERHVQEHQQFQDMVTGLSTELKTLSEKLADCGSPAMEQPSSEQK
Q-LKSQEQQAPLSRFEDTLKKILVLAEAVKQSTSSPGQKF-IKDEIETLQS-EHRSLEER
LENVKQKEENIFSEAL-ELKDELADEIQMEDKTDTMLEREIQVTSDTPVATEESFTTVEF
KECLEMHN----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------KEGAAVVVQKELLPGVQVNTEYFEEEQKVNELKNEVA
ELDIVLINEQLKELENLQTELETWKAKS--LSQEACPNATGSNSEELQTPEPVVPCWDRL
LQELDAVKAVKQQQYSLVNEYQKNLSAAQSSMKNLSTEKDNIKM-GPMNNTVLLEKIKAC
VQALHKERDVLNQLKAQQESLSQHLTCMDKVLTASQMKQLEQWWQHMEQTVQKKHDQVVA
EINEFNLLMNKAQDIQRLI-Q---E-QY-LQTELHSSAGEKVNYPVV-WTTELQDIKHGL
SLLKRRIELQMKRIWSDQEKMALENCIHDLQSKLETLSEQRTPQEDVQITGPALKKQEIM
NKLKENISWVKDSLSSLDQKAALFPSDVKSQIRNCELMRTEVLDREPVIESLDKELQHII
PSLKPEEISDMTFLLQALQNSYKALVLKSVQRLQHLELQLEERQRLTAEIEKVHCQLRNA
ETLARLDTNQNS-TWSELADQQAILKEILKDIQEIDGLISSHCKESQVMAGELSLSEQLF
LIDQLRSLKNRARKTQRQIQNKCHEVGKKIAVYREFAEGITSLQQDLND--LQCGEVN-L
ED-KLLGATQEVKNKCKALKEKVVCFQSNLSQMMKYKEIFECIGLNWDSQQLDELHELQT
KLI-----------HFDNVVREWDNLHSLLNEIWTMTSTVRKEASKLHDSSSSSP-AENL
VSAQILLQTVQQILYLTQEVENQINKNEVFDIPFKESKRQEIQSLKKDVEELIQLL-QN-
-LISSLQCVNKEDIQNEIERIFHTIKHIQLELQQPLLVDMK--MMQFEKMRWEAIQNMMT
AEFSAIKYLMEKERENEEEKS--LAADTETKLKTLQDHELQLKTDIASRVSALQDACKTG
ELYIEAVQKAAKFLEDYEAQVYSATAELSTSDEACQTPQWK-QEGFDSAVADIEKLGSKL
KNLVKPEDKINLENTLRELVNKSLALREKVQRKEADER--RYF------EKYKRYTESKD
KVRDDLNKLEKMLMQSLSQIPMSYKEALENLEESKILVSNIDSAEDDLVKLRQISGELMR
LRKGNDRAL-GRIVTALWENWLCLLEAAKELEINCEELKQEWKFISEELERETIILDKLQ
EEQPESLKEKEKANREELVELLDFVNSFEENINRQQLLLLLLLHRIKNILNTSENTEAEA
V-LPALCEIKTMQDRCKKLYEKTQEHKDLVQSEMQERKKINEEISAVKNALQNAASMLDQ
DAG----GKSGQLEEVQSVIGKESQTLKDIMEKLRIKYSEMYTIVPAEIEAQLEDCKQTL
QDLEDKVSFEILQSSPQYVLKRKAETINNGLQAIEKMLQQKSENIAKAKEVQKQIWDMLD
LWHYKLNELDAEVHDIVEQDSCHAQELMDILVTPLQQYQQVSQLAERRTAILNKAASKME
EYDELLKNMKVWIENTNCLLREDTQNDSAKSLHKYSDDLQMA-LEDSEQKQNLLHNVYLE
LEELTPVFETDSIMQ-QLNEADDQVAALQHEIAEILPQIQHVADELSAIESHVKVFEKDI
VKMKTILS-SEDLLEFSPKDQLKHGQ----------------------------------
-VILDHVGPMQKTIVHIQSYEEALQLPGVKTQPFLVFRKARQLLRELKKLEKITKEKNEL
LEE-ALKKTEECEQEIEKRKQFLKNHLVEISHENQPLAQKTSYPESQG-EMEAVKEEIIK
LCQRKEDILTGMKNSMSGLHQCLQQEVPDLG--DESPASEFA-QTDSI-----GTNVSDQ
QLKKRGMMFLLPCLDEESEDYSVHS---KGSTATETDKSCWPSEKDGEKHK-EDSTN-SW
SSGTLSDG----VSQVMHSGLSPQSSSTESGP-ELK---CTLKKNISPQT----DTPPVL
NATQCSPGKTG-DSEEEV--DGGRPEPETILQVCQAQVAELEQWLDKTKVSLGSDPQTPK
MQQMVELQLGDCQVMLSEIEQKVLSLLEDC-----GNSAGHQQETEALSLKLKEVKCNLE
KVQMMLQDKYNEEQFAIQNRERID--P--ESIKVLHSNGSSVPQLALAEQPFLQH-NGFQ
YPQ--DLKVKAAEQKSLIDFIESC-VEKM---QLQFEDSM-TQKLEP---------SN-G
ESDLKSKQADPTLSPKDQ-TGNKWQY-----L-QQELSSKMKSPLY-QLVEPQITTKLNM
LPRGMFASAGTPTVEELKTYTVQLGDLSQEANVVHAQDNVAEEVSSNLDRKLFELLLAIS
RCLNNMEEMLNTSVLSTEEAAVQQVLY----ETLSIELQKLHADLSDKKDDLLKSITCAG
GSTDVFCECFSNLQARLEQTQAATASRSNSMKAGLDHNSNYQNEVRLLYDQLTEKKATLQ
QCLNAICGHNISEQLQKTDVCALELQNFENQVAKLRGYGERFQLPITLIQEVYKLEDVLD
DMWRILKAKYVELNSPSISENQYEDLLRGFAELVAIGQEKVAQDAKQLTKSRAALQSYLE
NHKDFFHNLMTHMAFMQAFSEKVSPSILQKREKFWRELVNEVRLLEQKASQYGIHLESLL
KEWTEFDDECLAFSKELEAVNSTLPSVNLVEETEERLMERIALLQQIKSSVDGKHARLYQ
MVKEGKKLLTAVSCPEITSQIRKLEEQWLSLTKKIGNELHRLQTLLQLLV------SYNR
DSEELMKWLDSAQQRMNFWKEQSLSVSQDLPTIRDNINSLFTFSKEVDEKSSLKSSVVST
ANQLFHVKQADTAALRSSLAKFEQKWGELITQLPAIQEKLHQLQMEKLSSREAIAELMTW
LDHVEQQKGHEEPVNSQSSAAHVRSLLQKYKEYMMEMNFKQWMVDFVNQSLLQMSTCDVE
SKRYERTEFAECLGEMNLRWHGLQASLSRKIQDLEHLLEDITENENKAQTLHNWLEAQSD
RLRSLQTPESLMSAQNTLDDCKDLENQLATKSKMLDELIQTVA-LNE-SAEQSPEAAPFR
IAELCEMRDNVVSQVAQLKTSMQSILEQWRVYDEIYAEVSLMMTRYLYCIDQCKPSV--L
SLEALKKQVKTLQFLQDELENSEESWAKFQVAASNLKKNCSPSFAEIIDQKCTEAN--TR
WSSVNE---DITDQLRTAKAILQLWEPFDILCTEAAAKLQQHEEQCTQLLDAHMPEDNLV
ETLKQRIQDIK-NLQHGLQNIVGCRSQISELADQIKQ-QAGTAAQAVLLEKLQPLQRASY
LETMLQRKLDEFEFNLLQLEDFKNCLETLEGHV-KNCTDAFDSLHLEVE--TDNSELVMN
HTLELAALSPSIESLNEASIKLPLSDFTLKKMQSLTRQWSQKTATAL-ELCSVHEGTQND
-EKKFLQKCENWINFLEKMKEALKTNIPGRFEELQEQQRVYEMLQTEISINQQTFNSIIA
KVLLFLESGEAEKRTEFISKLTLLKEQWQNVIRLVQQRKKDID GLVSQWQIFR-SSLQ-S
LSRFLDDMNSFLLAVKSQDCYSLYHLRNLIQDFKSKAVILQRWQGMYSSVIDVGEKLRI-
-DSDPETSAAIQEGLSQLQQNWGDTQVQLENMKMKLSSVL-QSWNCCEKQTKELESRLRE
LKDEVKDQLPVENEELYKAKEHMKELEQSLADWAHNMKELRAMKVELAHCILTEDMMVLK
EQVEHLHRQWEELCLRVSLRKQEIEDRLNAWIVFNEKNKELCSWLVQMESKVLQTADVSI
EDMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKTRVAEIDDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLK ETF AFIQLLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHTAGVESVFNICEVLLHD
SDACANETECDSIQQTSRSLDRRWRNICAMSMERRMKIE ETW RLWQRFLDDYSRFEDWLK
SAERTAASPNSSEVLYTHAKEELKKFEAFQRQVHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVAAILRRLK HFT NRRDEFEATRENILVWLTEMDLQLTNVEH
FSKSNFDDKMRQLN-GFQQEITLHTNKIDQLIVFGEQLIQKSEPLDATLIEDELEELHRY
CQEVFGRVARFHQRLT SRHPGLDDEKETSENETDPED--SREIQNDLWHKKAIGDG----
PSSPQSLC----HLMPPTQ----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDE----EEATYYSAL-----------------------SGKSVSEAHP------
------------WHSPDSPVCRKHRYNQAEMVGNVLS-SPETSTPYKPGYVKQLSSASS-
TSVNKENIASANMSDEEPQ-DD-QELVNIAA-AEKQSGIIDRWELIQAQDLRNKLRMKQN
L QQWQQLNSDLSDVSTWLDKTEE-ELEELQKAKPPTSMHEMEQRVKKLKDLLKAFDNYKA
VVLSVNLSSKEFQKAESTEFKE--LQNRLRKVNLRWEKATHALNKWRKGLQQALLHCQEF
HDQSQKLVLWLASADSRRNEAQ-I-TDPNADPHTILECQKELMQLEKELLEQQPKVNSLQ
ELCSYLLLKLDGEDYIEAEEKVHVIGTKLKQLIEQVSHDLKTIQGNLDTRA-FLPV----
--PD--DLD-SGS-YHPVTVKASPPV-KKSC---CL-----------------FRAESHP
QPTKVVPRSPSFFYRVLRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----------------------MQELEKSLANWTLNLKELQTMKADLSQHILEEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWLLFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-SQLKQMGEQLIQASSKTRASEIKDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDKNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFSICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

-------MASSPELPTEDE-QV-SWAIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEPRG-KVKDAV--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFMESFNEEKKSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPKKLEEMK-RRI-NNILEKKFIL
LLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFVEEEELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKICNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDSSGN----------I-L-SKE
EKATVEFSTDTSIELPENSNQ--RIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIARGSMYDELMARTEDTLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSADV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIIYNTKSLAKYLKAVEELKSNVTEDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEMKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-MEATMKFNLASEL
KPPQKESIM---EKDYSASVNSLLERYDTYRDILERHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKKETDVCWKEFEIISLKLENHVSDIKKP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEQASLLLCGSD-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNITLKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTAKLSAEPF-IDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAELGEDTSCENLLGALSVK
LPETHGCGVQEEFTEENRLLEA-------CIFKNNELRKNIQDVQSQISKIGLRDPTVPA
VKHRKKSLIRLDKVLDEYEEEKIHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENAKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGTEKALQKMELHQLTEEDRERLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWMTNQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQGSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVNFSDKPVNQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEVIMSKQLSLNAQESMKNTDDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GSLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVV
EYDEFTTLMNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRRLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKQRE-EEKSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNPDESPEMPLRK-QEELESTIAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKETFKAQKNEAE--RYL------ENYKCYRKLEE
DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLRL
RCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELCELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
S-VLAFQEITSMQQRCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKEGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIERAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESKTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDAVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQE-QEVE--RDRLPAVAS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPPIE
AATVDSSDVQG-GLEPRV--EKTRPEPAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSELESIVTERPLFSRQKDFQ
QQ--QVLELKPMEQKDFIKFIEFN-AKKMWPQYCQRDKDT-AQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVELQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHC----ETLALELKKLYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTQAAALYRSKCLKAGLDYNCSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGMLRARYTELSSPFITESQQDALLQGMVELVKIGKEKLAHDYLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQITEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHHVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESNEGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDRWQNAVQGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTVKAGEKLLL-
-TTDLETKESVGRRISQLQDNWKDMEPQLAKMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTVDISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--HREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-GRLAGVTG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISTITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAH-V-TNPKADPQALLECRRELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPTP-PLPS----
--FD--EVD-SGD-QLPMASVPAPRAKLRAA----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSSEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MSSESESPSSPGEDQQMLRIDERHQ-----VLQ---------AEQEGTQKRTF
TNWVNSQLSKHPCPSVLRDLFTDIQDGHRLLDLLEILSGEDLPREKGNNVFQATNNINTA
LSYLEQRS------IKLINIHAADIISGKPSIVLGLIWKIILHF HIE----SLADILAAT
DSV-----HQSKSESKVV---PSPTASPPAKRSA----KSRWKS SARKVLLQWANEQCAG
-HGS-LSVTDFKSSWKNGLAFLAIIQSLRPEIVDMDKLKGKSSEENLQEAFRLAEQELKI
PRLLEPKDVNVPNPDEKSIMTYVAQFLQYANSAEAPKKDVQE-QVKKTI--------EWL
NLEEQKVKKLFSEMKTETYTKKYQE----MLLFMRKFNEQKRTFMSGLELKSLP---SNE
QQLIRQSLENITSQIAEWKKQLDLSLPSPLSDVESWLLKGEDLMSHKILDTETHNKAVSL
LQNSSASFKELLASADSHSQTLQTFKNLDDNGFVLVPTDKIEEMK-LRL-EKITAADFSL
MLDYRCSGHSILALLDEGRPKLKTWNTKCKTQGMAESLLADWKEFVEDMAFLIRLDAAFQ
NFVEL---KDKLL-AAYFIVDDSDISKEYKIIKMKYNEFVDLVHLASSNLEKLLSTWTHY
ENNFDLIRGWLEEQGRIAPTK-----VPSEILSKWKSVHASLNTDAKFLREQLHEKTGLQ
ISAELKHFNTQWAQFVKRHEKIKPMKK-L-NGTHLEPSDGKHE---------------KK
LTEPLLISADSLKILIENL---QEQE----------------------------------
--------ENAALQQVCKQICS---RVEKIDSLIDS------AAQWPPTAEIFFQSIDQL
KLMD--GSLTNKLQNLYAQGTICQKHLSMAEKDLKAVQQVIRSHDE---LKHFKTDGIQE
KLAL-IQQQVQELMSRSGSTLTSSELH-LSESDIKNKFESSKSKLETYITSAMCLMEQRI
TPEEFISQYENTLSGFDNHNLDEFLKAADEMKRISSAHEKSVVDKLSVDLRSQWKIIHTE
MESYVFRLKLHSEKKKCDDLFCEAEERLRIEEERVGLGDREDLIRQHKTQRIFSEDGCLG
QLCRCLQAMELLLAT-PR--NTEDNSAAQAIISECTRKKAEIEKRAGNIYLHL-----LS
PQGTCR--ITEKENKSVGLENGLKTTT--------CKSTGTY---A-----SQEIVETDS
GWI--------PYEESNTNLSFVLHRYDQEESNLEQFLHCCRQTFTTDNVMNS-QDVSSL
QTRLHELQ-LLQSQANTYWRCFETLSCDAEKLLDIPNNI-TLCEKRAELQSNMEIMKEEM
QSRIQLLSVTLHVLLPVQQEVDLLCQSNK---SDQELEKFTVSNIDSTCQELKD------
-ARNTVEDRLQQIDILESASQSGKKLNHVAMEAVESIKAELESTCETMREKEIILKALER
FLSSLEATRVSIVAQANVWGMDKATLEEKQKNLTVLENKIFHLNQEALQLD-DHLQGVEI
SLEEPEHGGETSCQKLIAGFPDKVESAKQAVLQELNNLHQKVEAGAIFPAEVALPVQKEV
TLARESSQLSQEQTLQQITLLNMDSVLQEIKDVQSSVEDEIRKCEDLQT--SAELCESLS
PVDFQEFHSTLYDFKANLKETNKDVKEREAVLKVLKKFLFSLKTAKLNIEEQSVVLERDR
PALEDKQTNLTILEKEVFRLEQ-EAQLLDGSLEMAGVYLEDPVSGGKTSCQDLIGGFSER
VGSAKE----NILQELRNLQ--WREDLEKLAVRQKELCKCVQDIYDKVDQIGLSDPTIHS
VQQRLKHLDELEKELDSHVNEKMDISKGLTDLLQIAQGKDFIGD---EDTETLWEDARQH
IIYCKEQCEKVMELLRKFQKCKATLSSLIHKGEITVSQQSSYMGKENVHKKLTEVDAVKQ
EFNEHSENIDELSSICKKLQFHLSRMKSCGNPPFQDEAHMIVDKWLDANEKLDSYSDNLK
SASCLWNKILQLSEDIDQWAECKIKYCKGSVLTEHDVLSLKAELQLHVEKIEDVSAKSFQ
IQKILELSDPPLELQVIKTSLLKKMDQIHEYSGREPGGDNHGS--QSMKGLKENESTQV-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------DAPHSNGLFWDNADKTEDFESLG---NALKN
GAM-E-GELEDQQTDVQVYAMSSDTTAVLQRASHQKGSE---------------------
------------------------------------------------------------
----------------------------------TSIPNKGIEALRLQLSDLMKRKEYLF
SNLQPGLQEKVEQLESFTCFLQEVNDFSDTLAALKPKDS-----TAALDSGVDEWADIQY
VHKHLIKQLQDTRQILENQVHRHEQYEVLITTLNSKMAGFSQELLNFTGSSWESAAGEQR
R-QKLQKLHVWIREMDTDLMQILELAEQVKQSTSAPGVKG-IQEATRKFQI-KIGDLEKK
LQSLKHDRSSP--PSL-KGNKEILA----QMAPEAV----------LPIQIDSVTAVTKV
------GKGRK-------------------------------------------------
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-

-------MASSPVLPVDNE-QV-SSGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVISDLFTDIRKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNQS------IKLINIHVTDIVEGNPSIILGLIWTIILHF HIE----ELTQTLSGS
YSQ-----PPVDDVSVP-D--SPAASSPPAKKCST--AQARWQL SAKKALLVWAQECCAS
-HES-ISVTDFKSSWRNGLAFLAVIHALRPDLIDMKCVKHKSNKDNLKEAFTIAERELKI
PRLLEPEDVDTVNPDEKSIMMYVAQFLQYSKNAPVIRSKAQS-KVEDAV--------AWL
TLQEEKLQQVQKDTANETYYNKYQR----LLSFVESLNEEKKSFLDLLSLKGNAQELSED
QRLLTEGWNGLHCQINAWKTKLEDALPPPLRDTQACLREVEELAEEALSASQDSSDPVAL
TQEKMTVFKNLMDRFDYHSNILLTFENKDEKDLPLVPPDKLEEMR-RRL-NNILEKKFIL
LLEFHYHKRSVLGLLDEVKSKLDVWNIKYGNRESVELLLEDWHKFIEEKEFLTQLEASFQ
RCGEI---YKN------LAGEYETINEQYMIMEQNVCMYRKNIENVKSALQKVLACWATY
LENLRSLKAYFEDTKKEQVTE-----VPFEMLSQWNADHTTLNEVGHLLIEVSNDEVGSS
ISKELRRLNKRWRKFITKTPLEMKLPL-T-KKRDEPIPEDSGT----------S-LPFKQ
EKLPVDFSMDTAVEAPENHNQ--NVK----------------------------------
--------AMEDYERENEESPEQLKVSEEVEKLTGQ------VEIWEAETRSVLDLLRHQ
DAMD--SSLEEALQHLSARGSMYEELLARTEDALQMDVQNISGPES---LQHVLTGGLQA
KIQE-ANEKIQITMVKLVTALKNSADA-CPDSDSKQRMEETQQEFELSVRKAEQLLAQRE
SQSELISKYKEALKIHNANSLVKYLKAIEELKPSVSEAAKLSLEEKSRVARAKWESLHHE
ISLYIQQLKIDIEKGKLNDTIAKLEKQINKEKKLIRRGKSKGLIKEHE--ACFGTDGIVG
QLDHHTGILRELSEE-LD--SQERQQEVKRALRDYEQKIERLLKSAAEVLTML-----KA
PAG-GS--SKVQGTMTATENGGKDSHSKGLIAKSDNQPSAAKASEA-MEPIKNFNQALEL
KPQGEEN-VEKNGKDDNASVNKLQERYDTQKEILELHLQNNKFRITSDFSDEKEWRSACL
QDKLKDLQ-LLKKETDAYWKEFEIASLTLESLVSDTEKP-IIVKARDTLKGKENDFQMPL
KTRLESLELALQVALPVE-ESLLLCDLD-LALREVAVQEFHLMDADSVYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIAICHDL-EEPGNSVLKGLH
PTDIGATQNIVLKCRTQLEQTSHRMQMAKDVLAALEDFLSSVAAVKLSKELF-TDPSAPD
AQGAPGTTVTKRDMEEEIRLMSNKARQLDKRLKKLGISFKDAERGGDSTCEKLVDAVSTE
LLDTQGPGTRQELAEENKLLEA-------CSSKNNELFKNIQDVQKQMSEIGLKDPTVPA
VKHRKKSLIKLEKDLDGYAAEKKHLEEMASSLPQFKDGREKILNEQCQNTVLLWDSTKTA
VTECLEQCGRVLELLKQYQNFKSVLTTLIQKEETIISQQASYMGKENLRKRMAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANVIVDRWLDINEKTEEYYENLG
RALALWDKLFNLKNFIDEWTEETLQKMGSHLLTEEDRERLKEELRMHEKQTSEFSKRVAE
IQFLLQSSEKPLELQVMESSVWNKMEHVKKCVTGEASSCALGGSQAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMIILENQIGCLTPELSELKKQYESVS
DLFNTKKSALQDHFSALLNDQCKNFNDWFSNIEMNLKDCFEPSETKKSVQHKLQKLSEFL
SLEGRGGKIQQVETVLQHVKKHLPKARVKELSSWLVSQEFQLEKMESICQARARELDSDL
QQLLRLEDDCGNLSKWLINQEEKWKETGESGEKAELFRQALARKREQFESVAQLSSFLKE
RGL--EE----EEVIMQSTHLMGRYQTFLRQLGRTEEEPQLPSEEGQSFDDLAHGVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDARIQAIMRQAQ------GCEALA
GQVQEMVADIREQWDSTQHLASTYLSHQEKLLQEGEKYLQSKEDLRLMLTELRK-KQEAG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQTLEGHVQEHHSYQVCVTDLNTTLDSFSREFVSFSDTPVNQTAIEDK
L-QKLQELESRLRLQDGTLKKILALAKSIKPNTSSVGQKI-IKDDIKSLKH-KQKDLENR
IALAKRETENCLNSLL-KSKRSAEK----QENS-AALNGEARATSDALESTQGSTAEGKS
EGDWDINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMVLSKQLSLSVQESMKSIDDEQKVNELRNQPL
ELDTLLRNEQLRAIEELYAQLEAKKEAIDSLAQSKCLHDSETSALGPHKARCSPHHLDSL
LQALTALKKNKESQYSLLQDFQERLAALESSMTASLAGEGSLKV-GALDSETYLNKIKKF
LELIEKEKGSLVDLQVQWETLSEHMTDMDKKLLGSQMKRLERGWEHLAHLAQKKYSQHTA
ECDEFASLRSKIRDTEISL-Q---QQQQQLLLGLKSPEDQDGSQSIVTLAAELQAARRGF
TAVRSRAEVQMKRLWGEKEKKILEDAIQNLKKQFEAL-EPLNLEVE-----SQIKKCDLK
SKMKETLLWIRNLLSELTLPISLLPDNILFQIRKCKVMHDSILDKQQAMESLAEEVLAEV
PNLTTPERDNVNSILQDLQNQYQMLVLQSTQRSQQLEFKLEERSKLFEMMKEAQLTLEGH
EALLVPKTEAPP-TEAELEHHHATLRASQKGLQEVESLISARLRELTDASEDLSVFERLF
LDNHLNNLKTRVSRIQRCIQSKCNEVEHKISSYREFHERESMLQKEVDM--VQHNKLL-L
HL----ETNQDAKEEFQHFKERLAGVRRSILDVLKLREVFDHIGLNWDGSQLD---QLQT
QVFEKEKELEEKIKQLNIFMAEHGKYQASLSQMRAMNLQIKKKAELVLKSPPPLP-ENDL
LNAQILIEKIDKAKCLHNDIIKKLSENKAFDDSFKEKEIAQLQLVTEENKKLHKLL-QTL
VLEFQPKEVDEKHFQDKLENSLHVLHGIKSQLEQPLLINLDIDHMQNEKDNCEAFQDQVH
AEMYSIKAMTPPENQRG-ENSS-ETSDTEAKLHDLEDLQMQLSKSIDLRTNVLDSAYENF
TCYSEAVSRAMEILGSLEAMFVSCRVDLHNPEEALTRSGWK-QEELESIITVIEDLTEKL
GSVSSPEAKMQLEHTLQDLLSKRLTLQEAAKAEQAKIA--RCL------EDYKGYRSSKE
EICAGLQRAETALGLAMVLLPASYKEALERLEQSKALVSELLSTKEELMQLRRVAGRLSG
CCTQGDGVSTLRAASALWDRWLCVLEAAQEWAMWSEDLKQDWKFISEEVEREAIILENLQ
EELPEMSKMKEAASTEALSEALASLCQYEESVEEQELLLRLLLQRMQGIRNVLEGSDATG
M-VPAHQEIAAMRERCCRLLQKVQNNKELIQTEIQERLNFTKEIIALKMLFQQSTNAFQN
MASEGRPQRAEQLEELQSFVEKGKLTFGNIMEKLRIKYSEMYTIVPAEVESQMEECRKVL
EDIDEKISGEGLRSSPSCVTGRKIEEINSGLQQVEQMLQQKSKNIEKAQDIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDKLMVPFQKYQQVSQRAEARTSQLNKATVKME
EYSDLLRSTEAWIENTSRLLVSPAHCDSSKTLSQHASALQMA-LEDSEQKHNLLHSVFTD
LEDLSIIFETDDLVQ-SIQELSSQVTALQQQIVESLPHIQRVADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILGNLRPMKKTIAEIVSYQVELQLPQPEVNPLPVFQRTNQLLQDVKLLENVTQEQNEL
LKI-VIKQTNECDEEIENLKQILSDYAAEFSLGHTSPDQATDLPAVQE-EIEAVEKQVLR
LNQKKEDLLVDLKAAILTLHEHLKQDQQEAE--RAGQSAT-T-SEDRAAER-EALEWKR-
--DRTGSMSFLPAVEEEAEESPVQSEDGCEEARPSAGS--QPFLWEQDEDL-EGNGA-AS
SSATVIQE----AERKISTCDRSMMQILAPDSPVTE---QDPEFSAGLSQTGDAATLPTE
AAALDFAVEQG-PLRPTV--EPAEPRPAEVLHVCQTQVAKLELWLQQASVAFEPETLNTD
MQQVVEQELVGCQAMLTEIEQKVASLLETCKDQCLGDSGTIQHEAEVLSLKLRTVKCNLE
KVQMMLQEKYSEDQ--FPTILKKP--S--EHLKFLRPVHLSELEFIVTERPQFSRLKDVP
QPQ--VLELKPMEQRDLIKFIEFN-AKKTWPQDCQQDGST-TQESST----------RGK
ASDSENEAPDSTSASQGQRSSDKWQY-----L-LHKLASRRRLPPP-QVVEPQITTGVGV
LPSVRVCSFKYPTIEELKTYTTLLEDLRQEANDLQTQENVTAEPYVSLDKKLFDLCLTLS
QCLGSVEELLQTPGLLREDTHSQQAHC----EELALELKKLYLALGDKKDDLLKAVTWPG
KNASLFLDCFNDLQLYLEHVQAKAAWRSKSLKAGLDYTHSYQNEIKRLYDHLIKSKTALQ
QSLNEISGQSIGDQLQKADAYTAELQKSENRVAKLRDEGERLGFPSTVLQEVHKLEDILD
SMWGILRARYLELSSPFNSESQLDALLQGLGELVSIGQEKLVQGHLQQAKSKAALQAQLQ
SHKVFFQKLVADMLLIQTYSAKMFPSLLQKREAFWAEQVSEIKSLEDKAQQCGVKLQSLL
QKWEEFDENYASLEKDLEILVSTFPSVNLVEETEERLMERISLYQQIKRNIEGKHARLYQ
TLSEGRQLAACVSCPELEGQIARLEEQGLALSRKTDHELHRLQTLLKHLL------SYNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNIKKFFDFSKEVDEKSSLKSAVVST
GNQLLHLKEADAATLRAALAQFEQKWTLLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MDNVEHQMAAEDSVCAPSSASQVKRLLRKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNGKIQHLEQLLESITEHENKIQILNNWLEAQEE
RLKTSEKPASVLSIEKLLLDCQDIENQLAIKSKALEELRQSHLTLES-GATPWLEDPASG
VDGFFQKRSSVLDEVARLRASVQSVLAAQKTCEKLYEEVCGTVVRFRYRAEHSKPET--P
SLEALASQVQTLQCLQDEAESSEGNWEKLQEVTAKLKESC-PSVAEIIEEKCQHTR--AR
WTQVNQ---DLADELQRASGLLQLWKAYHSAHTEVTAKLEQQEAKFQQLSKINTSGNNLA
ETLPLALQDIQ-ELQHHVQKTKEAVLQNSTLLERLPQ-PAETSVPELLSGQQHALQRAAY
LEKMLLMKASEFEFVLSQFKEFGDQLESLQDLI-IREEENLDKLYQLEK--EENPDSFLN
HVLALTAQAPAIERLNEVSLRLPLSDVAVKTLQQVNRQWVRATATAL-DRCSELQGIGLN
-EK-FLRYCEKWVLLLERSEEALRENVANSLPALREQQKTLEMLEAEVSISQPIADSYIT
QSLQLLDTTEIEKRPEFVLEFSKLVDRWQSVGQGIWQRKCEVTGRVQQQQSFS-TATE-D
LLRFLGATSLLLSAVKGQDRYSLLQTRELTQELKNKEIHFQRQQTTYALAVEVGEKLLN-
-TLDQETQESVDRRISQLRDSWDDTKRQLGLLLKQLQSTG-ETWDQCERKIKELKSRLQV
LKAQSKNPLPELHEDLQKEKELIKDLEKSLANWSQNLKELHTMKADLAAHVLAEDTMALK
EQIEHLHRQWEDLCLRVAARKQEIEDRLSSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQFKQMGDQLIKASNTARAAEINDKLHKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDGNMSNL
RTWLARIESELSKPVVYEVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLD-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHRRLTARTPGLEEEKEASENETDMED--PREIQADAWRKRGESEE----
PTSPQSLC----HLMPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAVSDVEIPENPEAYLKMTTKALRASSGKSISDSHS------
------------WHVPDSPSPAKHRYKQMEEDRSEPPIPSDASTPYKQPYVKLL-QPRI-
HGGKEG---ARVLNGSHQQ-EEEQQLASAAG-QQ--SGAFDTWELIQAQELHSKHRIKQN
M---QQLNSVISDITAWLEKTEA-ELEALKMAKPPSDIQELELRVKRLQEIVKAFDTYKT
LMVSVNVSAKESLPSESAEASE--LHHRLCQLNLHWETAQGKMDSWRETLRQSLLQCQDF
HQRSQSLLLWLASAEEQRQKAL-V-TDPKADHQDLLRCQKQLMQLEKELAECQPHVNSLH
ELSTSLLVKGNGEDYIEAEEKVHVIKKKLQQLREQVARDLLSLQRSQNPDP-ALPD----
--FD--EVD-SGD-QPPAASAPAPQA-KFLA----EGITEDEDNSD-------GRVSGPA
GPS-STKPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

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-IQ---------------------------------------------------------
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----------------------------------DSIAKQIEICNNL-EQSCNSALKELH
PLDLHVTQNIILEHRTQLEEMNHKVQRSQDALKVLEDFLASLRTAELSPELV-TDLSASE
TQVEPESTLTVGKKEGEIQVMKDKARHLDECLKMLNISFKDAEQGEDSSCEKLLDALSKN
VFEKGGYGTQEELTEEDKLLET-------CIFKNNELRKNIQDVHDQISKIGLKDPTVPA
VKQRKKSLIRLDKDLDEYEEEKKHLQQVANSLPQFKDGREKALSQQCQETALLWENAKAS
VTECLDQCERVLELLKQYQSFKSVLTTLIQKEENVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKVLQEMGLHQLTEEEREKLREELQVHEQKSSEFSKRVAK
IQSLLQSSDIPLELQVMESSILNKIEHVKMRLTGEPNYCALSGSPAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNEWFSNVKMNLKDCFESSETKKSVEQKLQKLSDFL
ALEGRGSKIQQVASVLNHVKKHLPKAHIKELNSWIVSQETDLEKMESICQVRAKELDYYL
QRLLRLQDDHRNLSKWLTNQEEKWKEMEESGEKTELFGQALARKREQFESMAQLNNSLKE
YGL-TEE----EEIIMESTHLTDRYQTLLRQLCEIDEDNKLLPAEDQSFKDLAHDVICWI
TGIKESLMVLNSSEGKMTLEERIQKIKEIILLKPEGDARIQRIMSQAE------SSEAPL
V--PQTLTDIKNQWDNTLHLAKTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPWLEIKQ
LHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLKTALDNISEEFVGFSDKPVDQEAVEEK
L-QKLQELEDRLSLQDGALETIVALAKSIKQNTSSAGQKI-IKDDIKSLKC-KQKDLENR
LESAKQETENCLHSIL-KSKRSTEK----KEKV-SLAGSERQVTSAVQESTQNSAVVGEL
EEDGEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVKMVLSRQVSLNVQEIMKNTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELYTHLEAKKAAIEPLEETESLNETEAGASVLPRARHSVHRLDSL
LQALATLKKNKESQYCCLKDFQERLAAIESLMRALLTEKESLKV-GSLDSVTYLDKIKKF
LASIEKEKGSLSKVKIEWENLSNCPTDMDKKLLESQIKQLEHSWEQVEQLVQKKYTQQVV
EHDEFTFLMSRIQDLETRL-Q---QQQQCLLLRLNSPEQ-EEKQSIVALATELHTIKHRF
SVLKGQTELQMKRIWGEKEKKILEDAINNLQRQLEAL-EPLNIEVE-----NQIKNCDVR
NEMKETILWVKNLLGELIPTISLFPDNILLQIRKCKVTHEGILDKQQAVESLVKEVKDNI
PNFTAHESDDLNNLLQDLQNQYQMLVLKSTQRSQQLEFKLEERSKFVASIEKVQLSLQGN
ETLIIPQMETTS-TETELEHQRVTLTTSQKELREIESVLSACLEELTDIYKDLSVFEKLF
LDDQLKNLKTRANRTQRFIQTKHNQVEHKLNFYREFHEKTSALQKEVDN--IQHNELL-L
NQ----EVNQDVKEHSYHLKDRLAGIQSSILRVLKLKEVFDCAGLNWDCSQLD---QLQT
LVFQKEKELEEKIKQLDTFVEEYGKYQASLSELRAVDLQIKKRAEAVLKTPNTSS-ESSL
LNAQILNQKIEKAICLSHEIIKKLSENKAFDDSFKEKEILQIKLYVEEHGTLRTVL-QNI
ALEFQPKEMDEENFQDKLEHSLHVLNQIKSQLQQPLLISLKTEHIQSEKDHCEAFQEQVQ
AEICSVRAVTVAEKQRE--ENSFEASDTESKLRDIEDLHMQLSASLDLRTNVLNDAHENM
THYNEAVTRAMRIIAAFEAIFASHRVDLDNPQEALGRPRWK-QEELESTIADIQDLTEKL
EAVSSPEAKQQLQCTLQELVSKNAAVREAGKVKEAEIE--RCL------ENYKCYRKIKE
KIYANLNQMETVLGQAMSPLPVSYKEALEHLEQSKALVSNLISTKEELMKLRQVLRHLRP
ACTDSDGVCLFRTASALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYEENVEKQQLLLTLLLWRIKSIQNAPESLEAVE
A-VPAFQEITSMQERCNKLLQKAKKNKEMMQKEIQERHSFTKEIISLKNLFQQTTTSFQN
MALQEDPEKAEEFEELQSVLTKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIEEKISNEVLKSSPSYAMSSKIDEINNGLYNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDKLMVPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWIERTSRLLANPADYDSSNVLSHRASTLQMA-LEDSEQKHNLLHSVFTD
LEDLSVIFETDDFAQ-SVHELRRQVTALQQKIMESLPQIQQMADDVVAIETEVKPMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQAGMKPLPVFQRTHQLLQDIKLLENVTQEQNEL
LKI-VIKQTNECDEEIENLKQILNNYSAEFSPEHISPGQAASLPQIQG-EIEAVEKQILS
LNQKKEDLLVDLKATVLNLHQRLQQEQRDSE--KEMLSAGAS-EEDGVAER-DVSQWKP-
--DRTGAMSFLPAVEEEAEESSLKSENGDKEAEPSSGP--WSLLGKHDKDI-EEDRA-SS
SSGTIIQE----AAGRISTCASSMAQILAPDSLGPE---QGPEFSLSPNQTEEGATPPIE
AAALGFSDEQG-AFEAKV--EKPRLEPTEVLHVCKTQVAELELWLRQANVAFEPETLDAD
MQQAVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQVMLQEKYSEDQ--HSTLLKKP--S--EHQKVLQPDNLSEFESVVTERPQFSKQKDFQ
QQQ--VLELSPMEQKDFIKFIEMN-AKEMWPQYCQHDKDT-THKSSV----------SDK
ASSPENDASDSVLSPQGR-SGDKWQY-----L-HHELSSKVRLPLP-QRVQPQVATNMSI
LPSVSVYNFRYPATEELKTYTTQLEDLRQEANNLQTQGNMTEETFINVDKKLFELFLTLS
QCLGSVEEMLQTPGLFREDACAQQVHY----ETLALELKKLYLALSDKKDDLLKAMTWPG
KNTSLLLECFDNLQVTLEHTQAAAASRSKSLXXXXXXXXXXQNEIKRLYDQLIKNKASLQ
QSLNEISGQSIDEQLQKADAYTVELQNSESRVAKLRDEGENLHLPYVLLQEVYKLEDVLD
SMWGILRARYTELSSPFVTESQQDALLQGMVELVNIGKEKLAHGHLQQTKSKVALQAQIQ
NHKLFFRKLVADMLLIQTYSNKMLPSLLQKKETSWAEQVKEVKLLEEKSHQYGIKLQSLL
QKWEEFDENYASLEKDLEMLVSTLPSVSLVEETEERLAERISFYQQIKRNIDEKQARLYQ
TLNEGKQLVASVNCPELEGQMAKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSGQLTKWLESSQQTLQYWKEQSLSVSQDLGTIRSNINDFLEFSKELDEKSSLKTAVVST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVERQTADEDAEHSLSSASQVKSLLRKYKEFRMEMDFKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKLQHLEQLLESITENENKIQILNNWLEVQEE
RLKTLQKPENVISVQKMLLDCQDIENQLAIKSKALAELRQSCLTSES-GTMPLLADTASR
IDGLFQKRSSVINQVNELKTSMQSVLQEWKIYDKLYDEVSTMTIRFWYCMEHSKPVV--L
SLEALTCQVQNLQSLQDEAESSEGSWKKLQEVIGKLKDYC-PSVAEIIEEKCQDTH--TR
WTQVNQ---DIADQLQKAQSLLQLWKAYNSAHTEAAARLEQQEAKYRQLANINMSGNNLA
EILTPALRDLK-ELQHDVQKTKEDFLQNSTLLDRLPQ-PTESSTNVLLSGQLHLLQRASY
LEKMLLVKANGFEVVLSQFKDFGDQLESLKGLI-MHEEENLDKLYQQEK--EENPDLFLN
HVLALTAQSPEVERLNEVSLRLPLSDIAVKTLQNLNRRWIRATATGL-ERCSELQGTGLS
-EK-FLSCCEKWVQLLEKIEETLKANITDSLPALLEQQKTYEMLEAEVSINQTIADSYIT
QSLQLLDTTEVEKKPEFVLNFTRLRDRWQSAVQSVRQRKSDISGLVRQWQSFT-TSEE-D
LLRFLTDTTHLLSAVKSQDCYSLYQTRSLIHELKNREIHFQRWQPTYALTLEAGEKLLN-
-ITNLETKESIDKRISQLQDNWKDTKLQVGEMIKQFQSIA-ETWDQCEKKIKKLESRLQV
LKAQSKDPLPELHEDLLKEKELIKELEKSLANWTQNLKELPTMKTDLTQHILVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNQTRAAEIDDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
PAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDEVEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDMED--PREIQTDSWRKRGVSEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISEGHS------
------------WHVPDSPSCPKHHYKQMGGDRNVQPTPSDSSTPYKPAYVSL-------
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----------------------MQELEKSLANWTQNLKELHTMKADLTAHILAEDALALQ
EQTEHLHRQWEDLCLRVAARKQEIEDRLNSWAVFNEKHKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASSTARATEIDDKLHKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDRNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

-------MASSPELPTEEE-QG-SWGIDNLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF H---------------
------------------------------------------------------------
-Y ES-VSVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEARG-KVKDAM--------VWL
TLQKEKLQKLLKDSENDTYFKKYNS----LLSFMESFSEEKRSFLDVLSIKWDPDELDKD
HLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAMTL
IQEKMTLFKSLMDRFEHHLNILLTFENKDENHLPLVPPDKLEEMK-RRI-NNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYVMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQLTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENYNQ--NIK----------------------------------
--------AGEKHEKENEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DDVD--TSMEESLKHLIAKGSMYDELMARSEDMLQMDIQNISSQES---FQHVLTTGLQA
KIQE-AKEKVQINVVKLTAALKNLTDV-SPELDIRLKMEESQKELESYMMRAQQLLGQRE
SPGGLISKYKEALIISNTKSLAKYLKAVEELKNNVTEDIKTSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIREHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TAG-GT--SKNKGTITTSENRRGDPHSEAPFAKSDNQPSTEK---A-MEPTMKFSLASEL
KPLQEESII---EKDYSASINSLLERYDTYKDILEHHLQNNKFRIASDFSSEEDRSSSCL
QAKLTDLQ-VIKSETDACWKEFEIISLKLENHVNDLKKP-FIIKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSD-LPLHKMAIQEFHLIDADHIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIEICNRL-EEPGNFVLKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRTPGLSAEPI-TDLSASD
TQVAQENTLTVRNKEGEIHLMKDKAKHLDKCLKMLDMSFKDVEWDEDTSCESLLDAFSIK
LSETHGYGVQEEFTEKNKLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDDREKTVNQQCQNTVVLWENTKAL
VTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIGEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKALQKMELYQLTEEDRERLKEELRVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCRALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKKSVEQKLQKLSDFF
TLEGRNSKIKQVDSVLKHVKKHLPKAHVKELTSWLVGQEFELEKMESICQARAKELEDSL
QQLLRLQDDHRNLSKWLTNQEEKWKGMEESGDKTELFCQALARKREQFESVAQLNNSLKE
YGF-TED----EEIIMESTCLMDRYQTLLKQLSEIEEEEKLPPTEDQSFNDLAHHVIHWI
KEIKESLMVLNSSEGKMPLEERIKKIKEIILLKPEGDAKIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGGEKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMVMSKQLSLNAQESMKNTEDEQKVNELQNQPL
ELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDNL
LQALITLKKNKESQYCLLRDFQEYLAAVESSMKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNRVTDMDKKLLESQIKHLEHGWEQVEQQIQKKYSQQVV
EYDEFTTLMNKVQDTEISL-Q---QQQQHLQLRLKSPEEQAGNQSMIALTTDLQATKHGF
SVLRGQAELQMKRIWGEKEKKNLEDGINNLKKQWETL-EPLYLEAE-----NQIKKCNIR
NKMKETILWAKNLLSELTPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQES
ETLIIPRVETAA-TEAELKRHHVTLEACQKELQEIDSGISTHLQELTNIYEDLNVFERLF
LDDQLKNLKIRTKRIQRFIQNKCNEVEHKIKFCRQFHEKTSALQEEVDS--IQRNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDAFEEEHGKCQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDETIKKLNENKAFDDSFKEKEILQIKLNAEENDKLYRVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVW
AEMCSIKAVTAIEKQR--EENSSEASDVKTKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKEAVTRAVESITSLEAIIIPYRVDIGNPEESLEMPLQK-QEELESTIAHIRDLTEKL
GMISSPEAKLQLQCTLQELASKNSAMKEAFKAQETEAE--RYL------EYYKCYRKIEE
DIYTNLSKLERVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRLLRL
RCTGNDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNIPESSGAVE
A-VPAFQEITSMQERCNKLLQKVQKNKELVQTEIQDRHSFTKEIIALKNLFQQTTTSFQN
MAFQDHPEKSEQFEELQSILKKGKQTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNKVLESSPSYAMRRKIEEINTGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQTQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHNLLHSIFMD
LEDLSVIFETDELTQ-SIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKRV
SKIKTILL-SKEIFDFSPEEHLKHGQ----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPEQAAKLPQLQG-EIKRMEKQILS
LNQRKEDLLVDLKATILNLHQHLKQEQEEVE--RDRLPAVTS-EEGGVAER-DASEWKL-
--NRRGSMSYLAAVEEEVEESSVKSEIGDEKAEPYPQS--WSSLWKHDKDM-EEDRA-SS
SSGTIIQE----PYGKISTCDNSMAQILTPDSLNAE---QGPECSLRPNQTEEGTTPPIE
AATLDSSDAQG-GLEPRV--EKTRPEPTEVLRACKTQVAELELWLQQANVAVEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHQEALQPVNLSELESTVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-TQESCA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHELSSKIKLPLP-QLVEPQVSTNMGI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEAINLQTQENMTEEAYINLDKKLFELFLTLS
QCLSSVEEMLEMPRLYREDGSGQQVHY----ETLALELKKFYLALSDKKGDLLKAMTWPG
KNTNLLLECFDNLQVCLEHTRAAAVCRSKSLKAGLDYNRSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQAYSAKVFPSLLQKRETFWADQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVISI
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKQHLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GAIPLLEDTASR
IDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVQKTKEAFLQNSTVLDRLPQ-PAESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-MHEEENLDRFYQQEK--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVALKTLQNMNRQWIRATATAL-EHCSELQGIGLN
-EK-FLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTTEIENRPEFISEFSKLTDQWQNAVQGVRQRKGDIDGLVRQWQDFT-TAVE-N
LFRFLTDTSHPLSAVKGQECFSLYQTRSLIHELKNKEIHFQRWRTTYALTLEAGEKLLL-
-TTDLKTKESVGRRISQLQDSWKDTEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLR--------------------------------------------
--------------------------------------------------------DCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PTSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPEHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PRVLNGSPQQ-ED-RRLAGITE-QQ--SGAFDRWELIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLCQLSLLWEAAQGTVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKAY-V-TDPKADPQALLECRRELMQLEKELVERQPQVDMLQ
EISNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPAP-PLPS----
--FD--EVD-SGD-QPPATSVPAPRGKFRAV----RTT--EG-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------------------------------------------------AEQEDTQKRTF
TCWINSQLAKHTPPSVISDLFTDIQKGHVLLDLLEVLSGQQLPRDKGSNTFQCRLNIEHA
LTFLKSRS------IKLINIHVADIIEGNPSIILGLIWIIILHF HIE----ELAQTLSCN
SNQ-----PSLDDVSVA-E--SSPTSSPPVKKCSK--AQKRWQM SAKKALLLWAQEQCAT
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKQRSNKDNLREAFRIAERELKI
PQLLEPEDVDVVDPDEKSIMTYVAQFLQYS KDAPGTGDKAQG-TMKDVM--------VWL
TQQEKKLQKMLKDSENETYCKKYES----LLSFLESFSEGKKPVLDILSMKGNLDELNED
QLQLRKAWDGLNYQINVWKTKLNDDLPSPLHQIEAWLRE-EGLTEADLPTSHDYYEAIAL
MEEKMALFKRLMDKCDCHSNTLLAFENRDEKQLPLVPAYKLEEMK-RRI-NNISGKKFTP
LLEFHYYKCSVLGLLDEVKSKLKAWNIKYGSKESVELLLEDWHKFIEEKDFLAQLESSFQ
KCEEI---HKN------LGGEYQNVSEQYMMMEHNISMCRK NIDNVKSTLQNVLACWTTY
TEKLCFLKACFEETKKEQITE-----VPSETLSQWNLEHTTLNEVGNFLIQVSNDEFGSS
ISKELRRLNKRWRKFVTKTQLEMKLPL-I-KKQEQPVLGNSEN----------M-QPSKE
EKPTVDSPTDTPLALPENHHQ--NIK----------------------------------
--------AGEEHEKEKEEFTGQLKVAEEVEKLTGE------VEIWEAETKSVLDLLRHK
DDVD--TSMEESLQHLIAKGSMYEELVSRMEDTLQMDVQNISSQES---LEHVLTAGLQA
KIQE-AKEKVQINMVKLGAMLKNSTDV-SPDLSARMKVEESLKELESYITRAEQLLGQRE
SRSGLISKYKEALLIFNTKSLAKYLKAVEELKNNVTEDVKLSLEEKSRDVCAKWESLHHE
MSLYIQQLKIDLEKGKISDTISRLEKQINKEKKLIRRGRTKGLMKEHA--ACFSEEGSLH
QLDHHMAVLRELCEE-LT--SQKSQQEVRRVLQDYEQKIERLRKCASEIHATL-----QP
PVG-GT--SKNKGTASTSENGGRDAHREAPSANSDNRPSTAK---A-VGSIKNLSLASEL
KPEQE-------EKDHNTSINSLQDRYDTHTETLELHLQNNKVRITSDFPSDGERSSACL
QDKLEDLQ-VLKNETDACWKEFEITSLQLEELESDIKKP-FIIKARDKLKEQEREFQMTL
NTRMESLETALQLVIPVEKASLLLCGSDLLLLHDVAIEEFHFTDADGIYQNLKD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIDICNNL-EQLGNFALKELH
PLDLRATQTIILKHRSQLEETNHRVQRSRDALRALEDFLASLKTAALPGGLV-TDPSASG
TQVAPEDMLTVKNKEGEIYLMKEKARHLDKRLKMLDISFKDAGRGEDMSCEKLLNALAEP
LFETRGSGGQEELTEEDKLLDA-------CIFKNNELLKNILEVQSQISKIGLKDPTVPA
VKQRKKSLIRLEKDLDDYEKEKKHLQEMAGSLPQFKDGREKALSQQCQNTALLWESTKAS
VTECLDQCERVLELLKQYQNFKSVLTTLIQKEENVISLQASYMGKDNLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANVIVDRWLDINEKTEDYYENLG
QALALWDKLFSLKDVIDEWTEKVLQKMELHQLTEVERDMLKAELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIEHVKMLLTGEPSCSALSGNTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKQSMVSLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLEECFESLDTKKSMEQKLQKLSDFL
TLEGRGSQVQQVETVVNRVRKHLPKARVQELNGWIIHQEIELEKMESVCQVRAKELDDYL
QQLLRLQDDHRNLSKWLTNQEEKWKEMEQSGEKTELFCQALARKREEFETVAQLNNSLKE
CGL-TEE----EEIILESTHLIDRYQALLRQI---EEEDKLPPAEDQSFNDLAQDVIHWI
TGIKESLMVLNSSEGQMPLEETIQKIKEIILLKPEGDAKIQRIRSQAA------NSKAPL
D--SETVADIDSQWVSTLQLANTYLSHQEKLLLEGEKYLESKEDLRLMLTELKK-KQEVG
FALQHGLQEKKAQLKNYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEESWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHTYQDCITDLNTELDNISKECVSFSDKPVDPIKVEEK
L-QELQELENRLRLQDGPLEKILGLAKSIEQNTSSAGQKI-IKEDIKSLKC-KQKDLEHR
LESAKQEMENYLNSIL-KSKCSTGK----KEKF-PLPGGEKQVTSDVQESTQGSAAAEKL
EEDLETNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMLLSKQLSLDVQESMKNTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELYTQLEARKAAIEPLEQTEYLNTTETSALALHSPRNSAQHLDNL
LQALATLKKNKERQYCLLQDFQEHLAAIESSLKVLLTEKESLKV-GSLDSATYVAKIQKL
LASIEREKDSLSKLKIEWENISNSLSDMDQKLLESQVRQLEQGWKQVEQLVHRKYSQHEM
EQEELTSLMSEIQELGLSL-Q---RQHQRLRLRLGSPEGQERDTGAVALATELQAVKHRF
SALKARAELQMKRIWGEKEKKILEDAINNLQKQLEAS-EPLNIEVD-----SEIRKSEIT
NKVKETTLWVKNQLGELVSSISLLPDSILSQIRKCKMRHDGILGQQRAVEALAEEVQDNI
PNLTAGEREELESLLQDLQDQCQRLVLESTQRSQLLERKLEERSTFLAEIGKVQLSLQGK
ETRIIPQVGTAS-TGAELERQRVVLTASQGELQEIASGLSAHLQELTRLCKDLSVFERLF
LDDQLKSLETRASRTQRFIQHKCSEVGHKMRFSREFQEQTSALQKELDS--VQHNELL-L
SQ----EVSEGVKGELRGLLGRLRGVQSSIRQALRLKEAFDSLGLHWDCSQLD---MLQF
QVFEKERELEGKIKQLDTFMAEYGRYQASLSKLRVMDLQIKERAEAVLKTPPTSP-ESRL
LGAQILNQRIERAMCLYHEIVKKLSENKAFDDSFKEEELLQTKLFAEENDKLQKVL-QNI
VLESQPKEMDEKSFQEKLENSFHVLNQIKSQLQQPLLINLKIEHIQKEMDNCEAFQEQVQ
AEMCSIKGVTVIEKQRE-KTSS-EASDVETKLRDIEELHVQLNASIDMRTNVLNDAHENM
TRYNEAVPRAMGVVAALEAFVASHRVDLDHPEESLEMPRGK-QEELGSTITDIQSLSEKL
GAIASPAAQGQLQCTLQELVSKNSALREAVRVKEAEIE--RCL------ENYTCYGKLEE
KIGTDLRRTEAVLAQSMAPLPVSYKEALERSEQSKALVSNLMSIKEEFMKLRQVLRHLRP
TFTDSDGIGLLRTVWALWEKWLSLLEVAKEWEMWCEELKQEWKFVNEEVEREAIILDNLQ
EELPEISKTKEAASTAELSELLECLRQYEETAEKQQLLLMLLLQRCRSAQRAPASGSSTE
P-APAAQEITAMQERCNKLFQKAQKNKELVQNEIQERHSFTKELMTLKNLFQQTASSLQN
MELQDHPERTEQFEELQSTSKKGTLAFENIMEKLRIKYSEMYTIVPAEIDAQVEECRKAL
EDLEEKISNEVLKSSPSYAMSRKIDEINKGLH KVEKMLQQKSKSIEKAQEIQKEMWDELD
LWHSKLNELDSEVHDVVEQDPGQAQEWMDRLMVPFQQYQQVSQRAEARTSQLNKATVKME
EYHDLLKSTEAWIENTSRLLANPADYDSSKTLSHHASTLQMA-LEDSEQKHNRLHSIFTE
LEDLSVIFETDDLAQ-SIQELSRQVAALQQNIMESLPQIQRMADDVVAIETELKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKI-AIKQTNECDEEIDHLKEILNNYSAELSPEDMSPDQAASVPQVQG-EVEGIEKQIMS
LDQKKEDLLADLKAAVLNLHRHLQQEQQELEKGKEVLSAGAS-EDEGVAER-DESEWKL-
--NRRGSLPVLPAVKEEAEESSVKSESGDK-AKPSSGS--WSFLWKHDKDG-EEDTA-SS
SSGTIIQE----EAGKISTCDSSAAQVLAAGSLNPE---QGPAFSPSPHQTEGGATPPIK
AAALGFSVEQG-ALPSPV--ENPRPEPAEVLHACKTQVAELELWLHQASVAFEPETLNAD
MQQVVEQQLVGCQTMLTEIEHKVASLLEHCKDQGLGDHGATQQEAEALALKLKTVKCNLE
KVQLVLQEKYSEDQ--HSTILKKP--S--EHQKVLQPDNLSEFESVVMERPQFGRQKDFP
QQQ--VLELKPMEQKDLVKFIELN-AKNMWPEHCQPDNDT-TQKSPV----------SGE
APSPENDAPDSVLSHQDL-SGDKWRY-----L-HQELSSKIQQPLP-QLVEPQVATEMSI
LPSVSVYNFRYPTAEELKTYTTQLEDLRQEANSLQTQENMTEETYIHLDKQLFELFLTLS
QCLGSVEELLQTPGLCREDVGAQQVFY----ETLALELKKLYLALSDKKKDLLKAMTWPG
RTANLFPECFENLQVYLEHTQAAAASRSKSLKAGLDYNRSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIDEQLQKADAYTAELRNSESRVAKLRAEGEKLRLPYALLQEVYKLEDVLD
SMWGMLRARYAELGSPCVTESQQDALLRGLEELVTIGKEKLARDHLEQTKSKGALQAQIQ
NHKLFFQKLVADMLLIQTFSSKMLPSLLQKKETSWAEQVQEVKLLEEKACQCGIKQQSLL
QKWEEFDENYASLEKDLEVLASTLPSVSLVEETEDRLVERISFYQQIKRNVDEKHARLYQ
TLNDGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLL KHLL------SYHR
DADQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNIDRFFAFSKELDEKSSLKTAVIST
GNQLLHLKEADAAALRAALAQFEQRWTVLVTQLPGIQEKLHQLQMEKLPSRKAITEMISW
MNNVERQTAGEDAAPSLGSASQVKNLLQKYKEEELILGVGGGVLDDSQERELRILILKIN
IRKSWYPTNRCEHGFLRDIWFQVDLWLNHKIQHLEQLLESISENENKIQILNNWMEVQEE
RLKTLQKPESVVSVQKTLLDCQDIENQLAVKSKALDELRQSCLTSES-GTVPLLEDTASR
IDGLFQKRSSVISQVNELKTSMQRLLQEWKIYDKLSDDVNRMTVRFGYCMEHSKPVV--L
SLEALKCQVQNLQSLQDEAESSEGRWQKLQEVIGKLKGSC-PSVAEIIEEKRHHTH--TR
WTQVNH---DIAEQLQTAQGLLHLWEAYASAHTEAVTRLDQQEAKYHQLANINMSGNNLA
EILTPALRDIK-ELQCDVQKTKEAFAQNSTRLDRLPQ-PAEPDTHVLLSGQRHSLQRASY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGRI-THEEENLDKLYQQEK--EGNPDSFLN
PVLALAAHSPEAEQLNEVSLGLPLSDVAVKTLKDMNRQWIRATATAL-ERCSELQGIRLH
-EQ-FLCCCEKWVRLLEKIEETLKMSIADSLPALLEQQMAYEMLEAEVSINQTIADCYVT
QSLQLLDTTEIEKRPAFVSKFTQLKARWQSAAQSVRQRKRAVAALVRQWRFFS-TPEG-D
LLRFLAATSQLLSAVRSQDCHSLFQTRSLIHELKNKEIRFERWQTTYELTLEAGEKLLS-
-TTNPESKESVSKRISQLQDNWKDTKIQVGEMIKHFQSIV-ETWDQCEKKIKELKSRLHV
LKAQSKDPLPEPHEDLQKEKELIKELEKSLANWTQNLKELQTMKSDLTQHILVEDVMVLK
EQIELLHRQWEDLCLRVAVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSI
EEMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNQTRAAEIDDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICTMSMERRMKIEETWRLWQKFLDDYSRFEDWLT
SAERTAASPNSFGGALHSRKEELKRFE---------VDPLQPCPGDTGPPLPRPGTVRQS
SGPKCCSLAXQRWDGLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVARFHRRLT SHAPGLEDEKEASENETDMED--PREIQTDAWRKRREMEE----
PSSPQALC----HLVPPGP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSAL-----------------------SGKSISEAHS------
------------WHVPDSPSCPKHRYKQMGGDRNVQPIPSDSSTPYKPAYVKLLLSPGT-
DGGKEG---PSVLNGSPQP-ED-EGLAPLTG-QQ--SGAFDSWELIQAQELRKKLLMK QD
L---QQLNADVNDTITWLKNTEA-ELETLKTAKPPSDAQELGLRVKRLKEILNALDTYKA
LVVSLNVSSKEFLQTGSGESKE--LHENVGQLRLHWDAARAAVESWREGLR QSL MQCQDF
HQLSQNLLLWLASAESRRQQAH-V-TDPKADPQALLGCREELLQLEKELMERQPQVNSLQ
EISDSLLIKGHGEDYIEAEEKVHVIEKKLRRLLEQVSHDLMSLQGSQIPDP-SLPG----
--LD--EVD-AGD-QPPAVCVPASPAKETGA----ERTTKGKNRTD-------SRVPGPA
DPG-RSRPQRSFLSRVLRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MATSSALPTEDG-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVISDLFSDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIIEGNPSIILGLIWIIILHF HIA----ELARTLSCD
YNQ-----PSLEVVSAA-D--SSPTSSPPPKKSSKEQAQARWQL SAKKALLQWAQEQCAL
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMDSVRHRSSKENLKEAFRIAEHELKI
PRLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPCTEASAQA-KVKDAM--------AWL
TLQEKKLQKMQKDSASETYVNKYHS----LLSFMESLNEEKEPFVDVLSPKGSTKELDED
QLQLRGAWASFTCQIAAWKAELDEALPSPLKETEAWLTDVEELVEEGLPTSQNYSEAVPL
IQEKMSLFKSLMGSSDYHSNILLTFENQDESRLPVVPPDKLEEMK-RRL-NTILGRKFIL
LLEFQASKYSVLALLDEAKGKLAVWNVTYETEESVAVLLEDWRKFIEEKKFLAQLDNSFQ
KCEET---YKN------LGRECESVKEEYVTLEKNVHLCRQHIHNTKATLQRVLTCWATY
KEDLPLLKASFEATKKDQIKE-----VPFETLSHWNTKYTSLNEVGSFLVEVSSGEVGAS
VSKELRRLNKRWRKFIPKTPLELKQPL-R-KIQDQTTGNGSGT----------I------
----LSEASAVPAEPHESHDG--DMK----------------------------------
--------AVEKQEDE--ESMGQSKVNEEVEKLLKE------LRLWELETKSILGLLRHG
DDVD--GSLVDTLQHLIAKGSMYEELLARTEDTLHMDVESVSNLES---FQNVLRAGLQA
KIQD-AKEGVQITMVELSALWKNLSGE-SPEQDVRLQLEEAKKNLESYIMRAQQLLGQRA
HPGGLISKYKEALEIFNTNSLAKYLQAVEELKHHAPSDEKLRLEEQYRDACAKWEPLHHE
ISLYIQQLKIAMEEGKLRDNIAKLEKQINKEKKLLRRGKTRGLIQEHE--VCFSPESVAH
QLEHHVGVLRVLCEE-LT--SPESQQELKRALRDYEQKIERLVKCASEIHMTL-----RS
SQE-DA--LEERGALTTTENGRRDAHSEALLEIPENQPSTEKVLNA-MEPLKNFSQTPEL
KPQQEGS-IVEKEGKDCKALSDLWERYDTQRETLERHLQDNKSRLTSDFPSESEWSSACL
QGKLTDLQ-VLRADTGACWDDFEVTSLNLESLVSDMEKP-ALAQARGLLMEKEQALRRLM
NPRMESLELALQIVLPLEKECALLCGLH-LPFCTVSVQDLHPVEVDGIRQNLQD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAQQMRICAHL-EEPSDSVPRDLH
TLDQRAIQDIVLKCRLQLETMNQKLEMSEATLEALEDFLASLRAVKLSVESP----ADPP
TSNAQEGTPAVRTVEEDILLVTEKAGPLDERLRMLGINVKDAEGGENTTCQKLLGALSVK
VSDSHGQSKQEGLTEDTTLLDA-------CSSKNHELLKNIQDIQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLNGLEEEKMRIQKMVNSLPKFKDGKEKMVIQQCRDTAALWDSVKAA
LTDCLEQCGSVLELLKQYQNFKNNLTALIQKEEGIISQQASYMGRDNLKKKVAEIETVKE
EFNEHLEVVDKINQICKNLQYHLNKMKTFEEPPFEKEANAIVDRWLDINEKTEEYGENLG
RALALWDKLFNLKSSIDEWTEKILGKLESHELTEEDRERLKEELNVHEEQASEFSRRMTD
IQLLLQSNEKPLELQIMESSVLSKMRDVKRYVTGESNSCMPSGSTAELREDLDQAKTQMG
MTESLLNALSPCDSLEIFTKLEEIKQQILQQKHSMTVLQNQIGCLTPELSELKRQYASVS
DLFNTKKSTLQDHFSTFLNDQCKNFNDWFSNIKMNLQECFEPPETKMSMEQKLQKLSDFL
TLGGGKSKIQQVQTVLQHVKMLLPKAHVKELNSWLGSQELELENMESACQARARELNDSL
QQLLRLDDDCRSLSKWLTNQEEKWKEMETPGEKMDLFHQALTRKREQFEIVARLNDSLKE
HGL-MEA----EETIKESTHLVDRYQGLLRQLHEIEEEDKLPPAEDQSFNGLAHDVTHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDAKIQMVVRQAE------HCEAPL
V--QETLTDLSNQWDHTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLRDLKK-QQEAG
LALQPGLPEKQAQLKICKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEIKQ
LHESLLQQLQDSVRKLESHVQEHSSYQICITDLNTTLDDISKEFVSLFDASKDQIMVEDK
M-QKLQELESGLRFQGGALKKASALAKSIKQNTSSAGQKI-IKDDIKSLKC-KQKDLEKR
IESVKRETENGLNSIL-ESKGSTEK----HAKF-PLPGGEMLATYDVPEPTQESAAAGKS
EGTWETNE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSSVEMILSKQLSLNIQESMQNTQDEWKVNELQNQPL
ELDIMLRNEQLKGMEELYAHLKERKAAIDLLEQSQHLSKTERRALALPTDRSPAYHMGSL
LQALLTWKKTKESQYGLLDSFQDQLIAAESSMNSFLAEAEGLKA-CSLDSAAYLGRIKKF
LGSVEKEKGSLSKLHAEWAHLSSLLSAEDQKLVEGQIKQLDRGWELVERLAHRKCFQQAT
EHSEFTYLQKKAQDIGVSL-H---QQQQCLLPRLNSPQQQEGSLDMVAPAAELQAIKYEL
SGLKRQAELQMKRLWGEREKETLEDALNSLNTQLEAL-EPLNREVE-----NRVKKCDLK
NRIKETLLWVKNMLAELNVPIALLPNDILSQIRRCKLIHDGILGKQQAVELLVEEVRGTT
PSLAACDNDGLNTLLEDLQNQYQVLLLKSTQRSQQLELKLEERSKLFAVIGNAKLALEKS
ESLMVPTQDKAS-TEAELERSRAVLKASQQQLREMESVISTHLQELTNAYKDANVFERLF
LDDQLKNLKTRTSRAQSCIQNNCNKVERKIKTHQEFHEQTAVLRKEVES--IQLSELLPL
HG----EIRQDAKEQLCHIKNKLAAVRGNISQVLTSEEVFDSLGLGWDGSLLE---QLQT
QVFERERELEEKIKQLDTFLIARDRYQALLSKIRGMDLQIKKRAKSLLKVPNKSP-KSTL
LSAQILIQKIEKAKGLRDEIMKKLSKSEAFDDSFKESEMLQLKLTAEEHARLQEDL-QNM
LLELQSKGVDEKAFHDKLENSLHVLKQIKSRLQKPLCVHLGIQHIQDEKETWEALGEQVQ
TEIFGIRAMRVAKEERE-ETAS-RTSGVEAKLQKLEGLQMELSKSIDLRTNILNDAYENA
THYDEIVTRAVGIITSLEAILLSYRVDLHHPKTSLELARCK-QEELQSAVTDIQNLTETL
GTISSPEAKEQLQGTLQELASKNSALKAVLEAQEAEDG--RCL------ENYRCYRKMRE
EICSRLRKMQTDLGQSMSPLPRSYKEALARLDQSKALTASLLSIKGDLVNLRQVLRCLRG
RCTESDGTRVLQVASALWERWLSLLEAARVWQQWSGELRREWKFISEEIEREAIILENLQ
EDFPEISKTKDTAPTEELCQLLDSLCQHEESVEKQQLLLALLLQRITSIQNIPEGTEAVE
T-TPALQEIRSMQERCNRLLQAAQNSKDEVQTEIEARHSLIKEITDVKHSFDQISTFSQN
LALEGQPGRAEQLQELQNSLQKGKLTFKNIMEKLRIKYSEMYSIVPSEIESQVEECREAL
EDADEKMSTEVSKSSPSCIMRRKIEEINNGLHGIEEMLQQKSKNIEEAQEIQKKIWDELD
LWHSKLNGLDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYSDLLKNTEAWIEKTSHLLANPACYDSSRTLSHRASTLQMA-LEDSEQKHSLLHSVFTD
LEDLSIIFETDDLIQ-SIQELSGQVAALQQQIVEALPHIQQVADDVVAIESEVKSMEKKV
AKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQTELRLPQTGTKPLPVFQRTNQLLQDVKLLENVTQEQNEL
LKV-IIKQTAECDGEIENLKQILNNYSAEFSPGHVSQKQVANLPSLQG-EMEGLEEQILN
LNQKKEDLLVGLKAAVLNLHEHLKREQQEGE--GDELSSGPS-EEGGAAERPPTSDRKL-
--NRTSSMSFLPVVKEEAEESSVKSEDGRKKTELPSAS--WSLLWKHSMDP-EEDGT-FS
SSATIVQE----ADGRISTCDSSMAHMFAPDSGSTE---QGPEPSPRLSQTGEGATPSIE
AAPLDFPHEQG-AFEATV--ERSRPQPSEVLHACKTQVAQLELWLQQASVAFEPETLDTD
MQQVVEQELAGCQAMLTDIEHKVASLLDTCKDQGLGDCGATQQEAEALSWKLKTVKCNLE
KVQMMLQEKYSEDQ--HPTALKQL--S--EPDLVLQPASLSELGSVITERPQFSKQKDVP
QTQ--VVELKPLEQKDLIKFTEFN-AKKTWLQYCQQDTDA-NQQSA-----------SSK
VPSPGNAAPDSGLPPQGQ-SGDKWQY-----L-HHELTSRPNSPAP-QLVEAQVVTNTST
LPSVSEYNFRCPTADELQTYTTQLEDLRQEANSLQTQESMTEETYTNLDKRLFELFLSLS
RCLGSVEELLQRPGLLREDASAQQALF----EKLALELKKLYLALGDKTDDLLKAVTWPG
KNTTLLPECFNALKVSLERTQAKAAWRSSSLKAGLDHSRSYQNEIKQLYSQLVKKKTALQ
QSLNEISGQSIDEQLQKADVHTVELQNSERQVAKLRNEGERLHFPHVLLQDVYKLEDVLD
SMWGILKAKYLELSSPFLSKSQQDALIQGMAELISIGKEKLATGPLQHAKSKVALQAQLQ
DHKGFFRKLVADVLLIQTYSAKMFPPSLQKGEIFGAEQVAEVKALEEDACLRGSQLQSLL
QKWQEFDDNYASLEKDLEVLTSSLPSLSLVEETEERLLERISFYQQIKRNIDGKHARLCQ
TLNEGKQLAASVSCPELEGQITKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYSR
DSDELTRWLESSQQTLNYWKEQSLNVSQDLDTIRNNIDSFFEFSKEVDEKSSLKSAVLST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRNAISEMISW
MNAMEPQVAGEDAELSQRSASQVKNLLQKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKIQHLEQLLESITENENKIQNLNSWLETQEE
KLKILQKPESAISMEKLLLDCQDIENQLAMKSKALDELRQSSLTLEG-GDMPLLEDMASG
IDELFQKKSNVTSQVYQLRASVQSVLQEWKAYDKLYDEANVMTIQLAYSMEHSKPVV--L
SMEALDCQVQNLQALQDEGESKEGSWEKLHEVVGRLKDSC-PSIAAIMEEKCQDVH--SR
WTRVNQ---DLADQLQEARGQLPLWKASHSAHTEATAWLQQQEAKFQQLANINMSGNNLA
DILPLALQDLK-ELQHDVLKTKEACLENSTLLDQLPP-PADPSTPGLHSGQLHSLQTAAY
LEKMLLAKSNEFEIVLAQFKDFGDRLAYLKDLI-MHEEENLNKLYHEEK--EEVPGSFLN
HVLALTAQSPDIERLNEESIRLPLSDITIKTLQNVNRQWIRATATAL-DHCRKLQGNGLN
-EN-FLLYCENWIQLLEKIEETLTMTVAHSLPALLEQQKTYEMLEAEVSVNQTVADAYVA
QSLQLLDTTETEKRPEFVSEVSKLSDQWQNAARGVQQRKCDIDRLVTQWQFFT-TSVE-D
LLRFLTDTGHLLSAAKEQDCYSLYQTRRLIHELKNKVIHVQRWRTTYELALEAGEKLRD-
-TPNPETKEFIDRQVSKLQDTWKDTELSLGEMISQLQNTA-ETWDHCEKKIKELKSGLQV
LNTQSRTPLPELHKDLHREKELTKEVEKSLANWTHNLKELQTMKADLSRRILAEDVTVLK
EQIELLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIDKLQ-----------------------------------------------KDCME
EISLFSENK-LQLKQMGDQLIKASSKAKAAEMEDKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPSLEDEKEASETETDIED--PREIQADSWRKRREMEE----
SSCPQSLC----HLVPP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSALSDVEIPENPEAYLKMTTKSLKASSGKSISESHP------
------------WHVPENPSHPKHHYKAMEGDGTVTPVPSDASTPYKPAYVKLLLHQGT-
DDGKEG---PRGSKGSSQQ-ED-EQLDTLTG-QQ--PGAFDRWELIQAQELHGKLRIKGN
V---QQLNSDIGNITAWLEKTEA-ELEALRLAEPPSDIQEIALRVKRLQEILKAFDTYKT
LMVSVNVSHRESLPSESPESTE--LQNRLHQLSLSWDTVQGEMDSWRRDLRQSLMQCQDF
HQLSHNLLLWLASVESRRQKAL-V-TSPEADRQALLECQKELMQLGKELEDHQPQVSSLQ
EIASSLLIKGHGEDYIEAEEKVHVIGKKLKQLREQVAQDLMSFQGSLNPDP-SLDS----
--FD--EVD-SGL-PPPAASAPVSYA-KFGA----ERSTKEEEAAD-------SRMSHLY
GPG-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLPTEDE-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWVNSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRSNIEHA
LRFLKNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----ELARTLSCN
YNQ-----PSLDSVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLQWAQEQCAM
-FES-VSVTDFKASWRNGMAFLAVIHGLRPDLIDMKSVKHRSNRDNLKEAFRIAERELKI
PKMLEPEDVDVVNDEKS--IMYV-QFLQYSKAAPGTGDKAQG-KVKDAK--------VWL
TLQEKKLQKMLTDSENETYCKKYES----LLSFLESFNEEKKPFLDVLSITRNLDELNED
QLQLREAWDGLNYQINVWKTELNHVLPSPLYQIETWLQGVEELIDEDLPASQDYCEAMAL
MQEKMTLFQSLMDKFDCHLNTLLTFENRDEKHLPLVPPNKLEEMK-RRX-XXISGKKIAL
E---QYYKCSVHSLLDEVKSKLVVWNIKYGSKESVELLLEDWHKFIEEKEFLAQLETSFQ
KCEEI---HKN------LAGEYPNISKQYTMVEYHFCMYRKNIYNVKSTLQKVLACWTIY
VEKLRLLKACFEETKKEQMKE-----VSFETLSQWNLEHTTLNEVGNFLIQVSNDEVGSS
ISKELRRLNKRWRKFITKTQLEVNLPL-I-KKQDEPFLDNSGN----------T-QLSKE
ENLTADFSTDMSVELPENHSQ--NIM----------------------------------
--------XXXXXX----XXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXX
XXXX--XXXXXXXXHLIAKGSMYEELVSRTEDTLQMDVQNVSSQES---LEHVITAGLQA
KIQE-AKEKVQINMVKLVAVLKNSTDV-SPDLDVRLKVEDSQKELESYITRAEQLLGQRE
SQRGLISKYKEALIIFNTKSLAKYLKAVEELKNNVTEDVKLSLEEKSRDICAKWESLHHE
VSLYIQQLTIDIEKEKLSDNIAKLEKQINKEKKLIRRGRTKGLIKQHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIESLRKCASEIHMTL-----QP
TVG-GT--SKNKGTADTSENGGRNALSEVPSAKSDSQPSAEK---A-MESIKDFSLESKL
KPQQEESVMEKYEKDHSASINSLLERYDTHRDNLELHLQNNIVRIISDFSSDKERSSVCL
QDKLTDLQ-VLKNETEACWKEFEVTSLKLEELESDIRKP-FLVKARDKLKEKERELQMTL
NTRMESLETALHIVSPVEKELLLLCDSD-LLLCEMAVQEFNLTDADDIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSVVRQIEICNHL-EQSGNFALKELH
PLDLHAAQNIILKHRAQLEEMNHRVQRSKDALKALEDFLASLRAAELSGELL-IDLSASG
SQVVPGSTLTVENKEERIHQMKDKARHLDERLKVLGISIKDAEWGENTSCEKLLNALSRS
LSETHGSGRQEELMEEDELLET-------CIFKNNELLKNIQDIHNQISKIGLKDPTVPA
VKQRKKSLLRLDKDLDECEEEKKRLQEMVNSLPQFKDGREKALSQQCQGTALLWENTKAS
VTECLDQCERVLELLKQYQNFKSVLTTLIQKEENIISLQASYMGKENLKKRIAEIEVVKE
EFNEHLEVVDKINQICKNLQFHLNKMRNFEEPPFEKEANVIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNGIDEWTEKILQKMELHQLTEEERQKLKEELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIEHVKMRLTGESYCSALGGSTAELREDLDQAKTQIG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNVKVNLKECFEPSETKKSVEQKLQKLSDFL
TLEGRGSEIQQVGTVLNHVKKHLPKAPVKKLNSWIVSQEIELEKMESICQARAKELDECL
QQLLRLQNDHRNLSKWLTNQEEKWKEMEGTREKTELFGQALARKREQFESMAQLNNSVKE
YGI-TEE----EEIVTESTHLINRYQTLLGQLCETDEEDKLPPAKDQSFNDLAHDVIRWI
TGIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTVVSQAE------SSKAPM
V--PKTLTDIRNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHDSYQVCITDLNTALDSISKEFVGFSDKPVDQIAVEEK
M-QKLKELENSLRLQDGTLEKILALAKSIKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMENCLNSIL-KSKCSTEK----REKF-PLPGREEQVTSDVQESTEDSAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMVLSKQLSLDVQESMKTTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELCTQLEAKKAAIEPLEQIEYLKKAETSALFPHSERYSVQHLDNL
LQALITLKKKKESQYCLLKDFQEHLVAVESSMKALLTEKESLKV-GPLDSSTHMDKIKKL
LASIEKEKDSLSKLKIEWENLSYCLTDMDKKLLESQMKQLEHGWEQMEQLVQKKYSQQVV
GHDEFTFLMSKIQDLEISL-Q---QQQQCLQLRLDSP-EEEGNQSMVALATELQTIKHRF
SVFRARAELQMKRIWGEKEKKVLEDAINNLQKQLEAL-EPLNIEVE-----NQIKKCETR
YKMKEAILWVKNLLGELIPTISLLPDNILSQIRKCKVVHDGILDKQQVVESLVEEVKDNI
PNLTAYESSDLNNLLQDLQNQYQMLVLKSTQRSQQLEFNLEERSKFVGVIGKVQLSLQGN
ETLMIPKMQTTS-TEAELEHQYVTLTISQKELQEIESVIATHLQEQTNICKDLSVFERLF
LDDQLQNLKTRANRTQRFIQNKCNEVEHKINFYREFYEKTSVLQKEVDH--IQHNELL-L
NP----EINPHVKEELYRLKDQITGIRSSILQVLKLKEVFDCIGLNWDWSQLD---QLQT
QILEKEKELEEKIKQLDTFVAEYGKYQASLGKLRAMDLQVKKRTEALLTTPDTPP-ESSL
LNAQILNQRIRKVMCLYHEIIKKLSENKDFDDSFKEKEMLQINLYAEESDKLHKVL-QNI
VLESQPKEMDEKNFQDKLENSLHVLNQIKSQLQQPLLINLQIEHIQNEKVTCEMFQEQVQ
AEMDSIKAVTVLEKQRE-ENSS-EASDVETKLHDIEDLYMQLNASIDLRTNVLNDAYGNM
ARYNEAVARAMGIITALEAIIASHRVDLDNPEESIEMPRRK-QEELKSAIADIQDLTENL
GTICSPEAKRQLECTLQELVSKDSAMREAAKVKEAEVE--RCL------ENYKGYRKIKE
KICADLSQMETVLGQSMSPLPMSYKEALERLEQSKTLVSNLTSAKEELMKVRQVLRHLRP
MCTDSDSLCLLRSTSALWERWLSLMEAVKEWELWCEELKQEWKFIHEEIEREAIILDNLQ
EELPEISKTKEAATTEEFSELLDCLCQYEENVERQQLLLALLLQRIKNIQNTPEGLRPMG
T-VSASQEIMSMQERCHKLFQKAQKNKELIQNEIQERHAFTKEIITLKNSFQQTTTFFQN
MELQDHPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDVDEKISNEVLKSSPSYSMSRTIDEINNGLQNVEQMLQQKSKNIEKAQEIQKAMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAEYRTSQFNKXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMA-LEDSEQKHNLLHSIFMD
LEGLSIIFETDTLAQ-PIQELSHQIVALRQKIIESLPQIQQMADDVVAIETEVKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIVSYRVELRLPQTGMKPLPVFQRTDQLVQDIKLLENVTQEQNEL
LKI-VIKQTNECDEEIEKLKHILNNYSAEFSHEHMSPDGAANLPQVQG-EIEGTEKQILS
LNQKKEDLLVDLKAAVLKLHQHFQQKQQELE--EEMLSARAS-DEDGGAER-DASEWKL-
--NRTGSMFFLPAVEEEAEESSLKSESGDKKAEPPSGS--PSLLWKHDKDV-EEDRA-SS
SSGTMVQE----AAWKISMCDSSTARIFAQDSLNTE---QGPEFSLSPNQTQEGTTPPIK
LAAPGFSDEQG-AFEATV--EKARPKPAEVLHVCKNQVAELELWLQQANVAFEPETLDAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSENQ--HSTMLKKS--S--EHQKVLQPDNLSEFESVVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-ANKIWPQYRQHDKDT-TQTSVS----------S-K
ASSPENDGPDLILSTQGQ-SGDKWQY-----L-HHELSSKIRLPLP-QLVQPQVATNMSV
LPSVSIYNFRYPTTEELKTYTTQLEDLRQEANNLQTQENVSEETYANLDKKLLELFLTLS
QCLGSVEEMLQTPWLLRGDVGAQQVHY----EALALELKKLCLAMSDKKNDISKAMTWPG
KNASLFLDCFDNLQIYLEHIQATTASRSKSLKAGLDYNRSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIDEQLQKADAYTVELQNSESRVAKLRDEGERLHLPSVLLQEVYKLEDVLD
RMWGILRARYTKLSSPFITESQQDALLQGMVELVNIGKENLAHDHLQQTKSKVALQAQIQ
NHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKLLEEKSHQCGIKLQSLL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLMERISFYQQIKRNIDEKHARLYQ
TVNEGKQLVVSVSCPELEGQIAKLEEQWLSLNXXXXXXXXXXXXXXXXXX------XYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKELDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLH Q LQMEKLPSRKAITEMINW
MNNVEHQTADEDSEHSLSSASQVKNLLHKYKEFRMEMDYKQWIVDFVNQSVLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNGKIQQLEQLLESITENENKIQILNNWMEAQEE
RLNTLQKPESVVSVQKTLLDCQDIENQLAVKSKALDELRQSYLTSES-GTMPLLEDTASR
IDELLQKKNSVINQVSELKTSMQSVLQEWKTYDKLYDEVNMMTIRFWYCMEHSKPVV--L
SLEAL-CQVQNLSTLQDEAESSEGSWKKLQEVIGKLKDYC-PSVAEIIQEKCQNTH--TR
WTQVNQ---DIADQLQRAQSPLQLWKAYNSAHAEAAARLEQQEAKYQQLANINTSGNNLA
EILPPALRDVK-ELQHDVQKTKEAFLQDSTLLDRLPQ-PAEPNTHVLLSGQMHSLQRASY
LEKMLLMKTNEFKFVLSQFKDFGDQLDSLKSLI-THEEENLDKLYQQEK--EGNPDLFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-QK-FLYCCEKWVQLLEKIEEMLKVNIADSLPALLEQQKTYEMLEAEVSINQTIADSYVT
QCLQLLDTAEIEKRPEFVWKFTRLKERWQSAAQGVRQRKSDIDELVRQWQYFT-TSEG-D
LLRLLTYTSHLLSAVKSQDCYSLHQTRSLIHELKNKEIHFQRWQTTYALTLEAGGKLLN-
-TTHLETKESIEKRISQLQDNWKDTKFQLGEMIKQFQSTA-ETWDQCEKKIKELRNRLQV
LKAQSKDPLPELHEELHREKELIKELEKSLANWTQNLKELHTMKTDLTQHILVEDVVVLK
EQIEHLHRQWEDLCLRVAVRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KXXXX
XINLFSENK-LQLKQMGDRLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSVQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTVAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLR HFT NQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLT SHTSGLEDEKEASENETDVED--PREIQDDSWRKRRESEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALXXVEIPENPEAYLKMTTKTLKASSGKSISEGHS------
------------WHVPDSPPCRKRRYKQVGGDRSVQPIPSDSSTPYKPAYVKLLLSPGT-
EGGKED---PRVLTGGPQQ-ED-EGLAALTG-QQ--SGAFDRWELIQAQELHSKLRIK QN
L---QQLNSDISDITTWLEKTEA-ELETLKLAKPPSGMQEMELRVKRLKEILKAFDTYKA
LVVSVNVSSKEFLQTESTDSEE--LQDRVGQLRLRWDAAQGAVESWREGLR LSL LQCQDF
HQLSQSLLLWLASAESRRQEAR-V-TDPEADPRPLLACQEELLQLEKELVERQPQVNSLQ
EISSSLLIKGHREDYIEAEEKVHVIEKKLKQLLEQVSQDLVSLQQSQNPDS-PLPS----
--LD--EVD-P-G-EPLAAPVPAPQA-KFRA----EITTKDKNKTA-------SRVPSPA
GPE-SSRPQRSFLWRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------------------------------------------------AEQEDTQKKTF
TCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----ELARTLSCN
YNQ-----PSPDSVSVA-D--SSPTSSPPAKKCSR--AQERWQM SAKKALLLWAQEQCAP
-CES-ISVTDFKSSWRNGMAFLAVIHALQPDLIDMKSVKRRSNKDNLEEAFRIAEQEFKI
PRLLEPE-----------------------------------------------------
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-

-------------------------------------------------------QKKTF
TCWINSQLAKHSPPSVISDLFTDIKQGHVLLDLLEVLSGQQLPRDKGTNTFQCRINIGHA
LTFLKNRS------IKLINIHVADIVDGNPSIILGLIWTIILHF HIE----ELAQTLSCH
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--ARARWQM SAKNALLLWAQEQCAT
-HES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMRTMKHRSNKDNLEEAFRIAEQELKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLQYSKDAVGTGDKAQG-KVKDAM--------VWL
TLQEEKLQKVLKDSENETYFKNMTTNSYFLLSFMESFDEEKKFFLDVLSMKRNPDKLDED
QLQLREAWDSLEYQINVWKTQLNYALPLPLKEIEAWLQEVEQLTAEDLPASWDYSEAMTL
TQKKITLFKNLMDRFDCYLNILLTFENRDEKHLPLVPPNKLEEMK-RRI-NNISGEKFIL
LLEFHYYKFSVLGLLDEVKSKLDIWNIKYGNKDSVELLLKDWHEFIEEKEFLVQLDTSFQ
KCEEI---YKN------LAGECQNIRKQYMMVKYNVCMYRKNIYNAKTTLQEVLTCWAAY
VENLRLLKACFEETKKEQIKE-----VPFETLSQWNLEHTTLNEAGNFLIEVSNDAVGSS
ISKELRRLNKRWRKLISKTQLEMKLPL-V-KKQDQPIFDNSGN----------I-V-SKE
EKPTVDFLVDMSIELPEYHYQ--NIK----------------------------------
--------AGEEHEKEHEEFIGQLKVAEEVEKLIGQ------VEIWEAETKSVLDLLKHK
DDVD--TSMEESLQHLIAKGSMYDELMARAEDTLQMDIQSISSQES---LQRVIKGGLQT
KIQE-AKEKVQINVVKLVAVLKSSTDI-SPEVDVRLKMEESLKEVESYITRAEQLLRQRE
NPGGLISKYKEALIISNTKSLTKYLKAVEELKNNATEDVRLSLEEKSSAICAKWESLHHE
LSLYIQQLKIDIEKGKLSDNISKLEKQVNKEKKLIRRGRTKGLIKEHE--ACFSEDGIRY
QLNHHMDVLRELCKE-LT--SQKSQQEVQRVLKDYEQKIERLLKCASEIHTAL-----QP
TMG-GT--SKNEGTTTTSENRGRDFHSEGPFAKSDHQPSTEK---A-MEPITNFNLASEL
KPQQEESITEKDEKDHSASVNTLLERYDTHKEILELHLQNNTFRITSDFSTEKERSSSCL
QDKMTDLM-VLKNETDACWKEFEITSLKLENLVSDEKKP-FIVKDRERLKGKERELQMTL
NARMESLETALQIVLPVEKESLLLCGLD-LPLQEMTIQEFYLIDADGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------NSTAKQIEICNNL-EESGNFVLKKLH
PFDLHAMQNIILKCKTRLEEMNHKVQTIGDALKALEDFLASLRMSKLPVELV-TGRSASD
TQATSESTLTVKNKEEEIRLMKDNARHLDERLKKLDMSLKDAERGEDTSCEKLFDAVSVQ
LFEICGYGVQEELTEENKLLEA-------CIFKNNELLKNIQDVQNQISKIGLKDPTVPA
VKHRKKLLIQLDKDLDEYEEEKKHLQEMANSLPQFKDGREKTLTQQCHNTVLLWENTKAL
VTECLEQCGRVLELLKQYQNFKSVLTTLIQKEENVISLQASYMGKDNLKKRIAEIEVVKE
EFNEHSEVIDKINQICKNLQFHLNKMKTFEESPFEKEANIIVDRWLDLQTK---------
---NLWHYIFIWGFKS-----------IFLKKNCGIEIRETEELQVHEQKTSEFSGRLAE
IQFLLQSSEIPLELQVMESSISNKMEQVKKCLTGESNCSALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMTLLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLSDQCKNFNDWFSNIKMNLKECFESSVTKKNVEQKLQKLSDFL
ILEGRSSKIQQVDTVLKHVKKHLPKAHVKELTSWLAGQEFELGKMESICQSRAKELDDCL
QQLLRLQDDHRNLSKWLTNQEEKWKEMEESGEKAELFCQAFARKREQFESLAQLNNSLKE
YGL-TGE-----EVITESTCLIDRYQTLLRDLSEIEEEDKLPPAEDQSFNDLADDVIHWI
REIKESLMVLNSSEGKMPLEERIQKIKRSEQTLILKTAKICFLMEN--------------
--------RVTVEWAKKFR-----------------------------------------
-----------------------------------------------------SW-----
---SLPARRVDSVQKLEGHVQEHHSYQVCVTDLNTTLDNFSKELVSFSSKPVDQTAVEEK
L-QKLQELENRLSVQDGMLKEILALAKSIKQNTSSVGQKI-IKDDIKSLKC-KQKGLENR
LESAKQEMENYLKSIL-KSECSTEK----KEKF-TLPDGEKQTTSDVQESIQESGAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMVMSKQLSLDVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLKEIEELCSQLEAKKAAIEPLEQTECLKQTETSASVFYNTRYSAHHLDNL
LQALNTLKQNREIQYCLLKDFQEHLAAVESSMKALLTEKESLKV-GPLDSITYLDKIKKL
LSSIEKEKGSLSKLKIEWENLSNHATDLDKQMLESQIKQLERSWELVEQLVQKKYSQQAV
EYDEFMSLMNKMQDVESSL-Q---QQQQCLQLRLNSPEP-KGNQSMIALATQLEATKHRF
SVLKGKAELQMKRIWGETEKKILEDTINNLKKQLEAL-NPLNLEVE-----NQIEKCDIR
NKVKESMLWIKNLLSELVTPISLLPDDILSQIRKCKVTHDVILERQQAVELLVEEVKGNV
PSLTAYEGNDLNNLVEDLQKQYQMLVLKSTQRSQQLELKLEERSQFFAIITKVQLALEGK
ETPIIPKVETAS-TEAELEHHHVALKASQKELQEIESVISMHLQKLKNIYEDLSVFERLF
LDDQLKNLNTRANRTQRFLQNK--------------------------------------
----------------------------------------------W-------------
-----------KIKQLETFQAEHDKYQASLSKIRAMDLQIKKRAEEVLKAPDTSP-EFNP
LNAQILNQRIEKAKCLYDEILKNLNENKAFDDSFKEEEILQIKRNAKENDELHKAL-QNM
ILHFRPKEMDKKNFQDKLENSIHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQAQ
AEMYGIKAVTPIEKQRE-EENSFEASDVETKLRDIEDLQMQLSTSIDLRT----------
----------------------------DKSDPFISISLVA-PIELRTKF---------F
GFFVFRDSKIQWK---------------------------KYL------KNYQCYRKIKE
KICTNLSKTEAVIAQSMFPLPVSYKEALERLEQSKALVSNLISIKEELTKLRQAFRHLRP
RCTEDDGVCLLRTLSVLWAKWLGLLEAAKEWEMWCEELKREWKFVSEEAIQEP-------
-TRSCLIRTKDAPITQEVTEVLGALCQ--------------------------------G
L-RNNYIPVLSF-----RVFQKAQKNKELIQTEIQERHSFTKEIIALKNLFQQTTTSFQN
MALQDYPEKAEEFEELQSILRKGKLSFENIMEKLRIKYSEMYTIVPAEIEYQVEECRKAL
EDVDEKISNDVLKSSPSCVMNRKIEDINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVHDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATLKME
EYSELLKSTEAWIESTSRLLANPTDYDSSRKLSHHASTLQMA-LEDSEQKHNLLHSIFAD
LEDLSVIFETDDLTQ-SIQELSNQVTALQQKIMESLPQIQRMADVSLH------------
----------------HKESHVKAIT----------------------------------
-VILENIRPMKKTIAEIVSYEVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIEHLKQILNNYSAQFSLEHMSPDQAANLPQVQG-EIKDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEEAE--REMLSAIAP-EEGGVAER-DASEWKV-
--NRRGSMSFLAAVEEEAEESSVKSESGDKKAEPSSRS--WPVLWKHDKDM-EEDGA-SS
SSGTIVQE----ADGKISTCDSSMAQILVPDSLSTE---QGPEFSL-PNQSEEGAAPPVT
AAALDSSDGQG-AFEATV--EQSRPEPAEVLHVCKSQVAKLELWLQQANVALEPETLNAD
MQQVVEQELVGCQAMLTEIERKVACLLENCKDQGLGDSGATQHEAEALSVKLKTVKCNLE
KVQMMLQEKYSEDQ--HPTILKKP--S--EHQKVLQPVNLSKLESIVTERPQFSRQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-AKKRWPKYCQHDKDT-TQESSV----------SNQ
ASSPENDVPDSVLSPQGQ-TGDKWQY-----L-HHELSSKIRLPLP-QLVEPQVATNKSI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEANNLRMQETMTEETYINLDKKLFELFLTLS
QCLSSVEEMLQTPGLLKEDVSAQQVHY----ETLALELKKLYLAMSDKKADLLKAITWPG
KNTNLLRECFDNLQVCLEHTQATAASRSKSLKAGLDYNHSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIGEQLQKADAHTVELQNSESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGILGARYTELSSPFITEKQQDALLQGMVELVNIGKEKLVQDHLQQTKSKVALQAQIE
NHKVFFQKLVADMLLIQTYSAKMFPSLLQKRETFWAEQVAEVKLLEEKSRQRGVKLQSWL
QKWEEFDENYASLEKDLEILVSTLPSVSLVEETEERLLERISFYQQIKRNIRGKHARLCQ
TLNEGKQLVASVSCPELEGQIAKLEEEWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSREAITEMISW
MNNVEHQTADEDSARPPGSVSEVKNLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNHQWHRVQGTLNRKIQHLEQLLESITENENKIQILNNWMEVQEE
RLKMLQKPESVISVQKLLLDCQDVENQLAIKSKTLDELRQSYLTLES-AAVPLLEDTASR
IDELFQKKNSVVSQVNQLKTSVQPALQEWKIYDKLYDEVNMMTIRFGYGVEHSKPLV--L
SLEALRYQVQNLQSLQDEAESSEGSWEKLREVIGKLKGLC-PSVAEIIEEKCQDTH--TR
WTQVNQ---DIADELQKAQSLLQLWKAYNSAHAEAEARLKQQEAKFQQLANINMSGNNLA
EILPPALQDIK-ELQRDVQKTKEAFLQNSPLLERLPQ-PTESSTHMLLPGHLHSLQRAAY
LEKMLLVKADEFEFVLSQFKDFGDRLESLKGLI-MHEEENLDSLYQQQK--EENPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLTDIAVKTLQNMNRQWIRATATAL-EHFSELQGIGLN
-EK-FLHYCEKWVQLLEKMEEMLKVNIADSLPALLEQQKTYEMLEAEVSVNQTIADSYVT
QSLQLLDTPETEMRPEFVSEFSKLTDRWQSAARGVRQRKGDIDELVRRWQYFT-TSVE-D
LLRFLADTSHLLSAVKGQDRHSLYQTRSLIHELKNKEIHFQRWQTTYSLTLETGEKLLH-
-TTNLETKESVHERISQLQDNWKDTKLQLAEMIKQFQSTA-ETWDQCEKKIKELKSKLQV
LKARSKNPLPELHEDLHNEKELIKELEKSLANWTQNLKELQTMKADLTRHILVEDVMVLK
EQTEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTVDISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKTRASEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPHSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSH-PGLEDEKEASENETDMED--PRELQTDSWHKSGESEE----
PASPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQMEGDRDGPPIPSDSSTPYKPPYVKLLLPP---
--GKEG---PRVLNGSPQQ-EE-ERLAGGTG-QQ--SGDFDRWELIQAQELHSKFRTKPN
L---QQLNSDISDITTWLKKTEA-ELEMLKMAKPPSDIQEMGLRVKRLQEILKAFDTYKA
LVVSANVSSKEFLQTESAESTE--LQSRLHQLSQCWDAAQGAVDSWREGLRQSLMQCQDF
HQLSQSLLLWLASAENRRQKAH-V-TDPKADPQALLECQKELTQLEKELVERQLQVDSLQ
EISNSLLIKGQGEDYIEAEEKVHVIEKKLKQLLEQVSQDLMSLQGSQNPDP-SLPG----
--LD--EVD-AGD-QPPAASVPAPHA-KVRA-----PSFCENFAAS-------LTFCVGR
VPG-GARPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MVHEGNQRWDTLQRRATAVLRRLRHFTNQREEFEGSRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHRR LTARAPGLEEEKEASENEADMED--PREIQTDAWRKRGEGEE----
PTTPQSLC----HLVPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAV-----------------------SGKSMSEGHS------
------------WHVPDSPSHAKHRYKQME-DRSDPPVPSDSSTPYKAPYVKLLLHPGTA
DGGKGG---ARVLNGSPQQ-EE-QQLAALTG-QQ--SGAFDTWELIQAQELHSKLRIKQ N
V---QQLNSVISDITAWLGKTEA-ELETLKMAEPPSDIQDLERGVKRLQETVKAFDTYKT
LMVSVTVSAKESLPSESAESAE--LRRRLCQLSLRWEAAQGEMDSWRARL RRSLL QCQDF
HQRSQSLLLWLASAEDQRQKAL-A-TDPEADPQLLLHCQKQLTQLEKELAERQPQVSSLH
ELSTSLLLKGNG-DYVEAEEKVHVIKQKLQQLQEQVARDLLS LQRSQV-NP-ALPA----
--FD--EVD-AGD-QPPPAAVPAPQAKVRAI----FRR-------------------TAP
GQA-PGPRRRS FLSRVIRAALPLQLLLLLLLLLACLLPTSEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

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----------------------VQDLEKSLANWSQNLKELHTMKADLAAHVLAEDTMALK
EQIEHLHRQWEDLCLRVAARKQEIE DRLSSWIV FNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQFKQMGDQLIKASNTARAAEINDKLHKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDGNMSNL
RTWLARIESELSKPVVYEVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

-------MATSPVPPTEDG-QD-FLGIDDLHF-----SLQ---------AKHEDTQKKTF
TCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----KLAQTLSCD
YNQ-----PSPEVVSVA-A--SSPTSSPPTKKCSK--AQARWQWS AKKALLQWAQEQCAG
-SES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKEAPGPGGSAQA-KVRDAM--------VWL
TLQEKRFQRTLKDSASEAYCNKYHS----LLSFMESLNEEKESFIDVLSLKGRIEELNED
ESRLRQGWTSLMNQVAAWRTELDDALPSPLKETEAWLKDIEGVVEEGVPISQSYSEARTL
IQEKISSFKSLMGSFGYHSNVLMAFQTNAEKSLPAVPPAKLEEMT-RRI-NNVLGKNFIP
LLEFHDSKCSVLALLDEAKAKLDVWNGTYGSKESVESLLEDWHKFTGEKKFLAQLDTSFQ
KCEEM---YKN------AARECESIREEYVTLEKNVHSCRQYIHNTKATLQRILMSWATF
EEDLSLLRASFDSTKKEQIKE-----VPVETLLQWNTKHTSLNEVGSFLVEVSSREVASS
VSKELRRLNKRWRKFITKTPLELKLPF-V-KIQDQPPGDSSGT----------P-L-SEE
--------SALSAEPGGSRSE--DIK----------------------------------
--------AAEKQEVEDEASAGQLEVNEEVEGLFKQ------VTIWESQTKSILDLLRHQ
DHAD--GSSADTLQHLIAKGSMYEELLARTEDTLQMDAQNPSNMES---FQNVLRAGLQA
KIQE-AKEGVQITMVELSAVLKNLSDE-PLEPDVRLKVEEAQKELESSILRAEQLLGQRE
RPGGHLSKYKEALEILNTNSLAKYLQAVEELKCTVPGGAKLQLEEQSRVASAKWEPLHHE
ISLYLQQLKIAIEEEKLRDNIARLEKQINKEKKLIRRGRTRGLHKEHE--ACLSPESIKC
QLEHHVGVLRVLCEE-LT--SPEGQQELKRALRDYEQKIARLLKCSSEIHTTL-----QS
CQG-GA--SEERGALITTENGRRDADGEAPLEIPDNQLSTEK---A-MEPIKNFSQTSEL
KPQQEESIMEKEGKDCSTSLNDLQERYDTQREILENHLQDSKSRVTSDFASERERSSACL
QGKLAELQ-VLQADTDAHWDEFEITLLNLRRLVSDTEKP-VLDQERDLLKGNEQVLHVLL
NTRMESLEMALQTVLPLEKECSLLCASD-LPLCTVAVQDLHPVEIDGAYQNLRD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIRVCTSL-EEPSNSVPRELH
TLDQCAVQDIVLKCRLQLETMNQKVEMREDALDALEEFLASLRAAELSAELP-ADLP---
APKAPEDTPAVRRAEEDILLMKEKAGPLDERLRTLGIIVKDAKGGETTTCERLVGALSVN
LAAVDGQRKEERPPEDKKLLEA-------CSSKNRELFKNIQDLQNQISKIGLKDPTAPA
VKHRQKLLLRLDKELDGFEEEKVRIQKTASSLPQFKDGSEKIVIQQCEDTAALWESTKAS
VAESLEQCGSALELLRQYQNIKNNLTALIQKEEGIICQQASYMGKENLKKKIAEIETVKE
EFSDHLEVVDNINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLG
RALALWDKLFNIKNNIDEWTEQILGKAESHELTEEDRERLKEELKVHEEQTAEFSRRVAD
IQLLLQSNEKPLELQVMESSVLSKMKDVKTHVAGESNSYAPSGNTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTILENQIGCLTPELSELKRQYASVS
NLFNTKKNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQKLQKLSDFL
TLGGGNSKIQQVETVLQHVKMLLPKAHVKELDSWLKSQELELENMESICQTRAGELNNSF
QQLLRLEDDCRSLSKWLTTQEENWKEMEVSGGRMDLFSQGLTGKREQFETVAQLSDSLKE
HGL-AEG----EEPIKESTHLIDRYQALWRQLHEIEDEDKLPATEDQSFNDLAHDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAE------HCESPL
A--QETLTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKK-QQEAG
FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKH
LHESLLQQLQDSVQKLKDHVQEHSSYQACLTDLSSTLDDISKEYSSLCDGSKDQIMVKER
M-QKLQELQNRLHFQGGALKKASALAKSIKQNTSSLGQKI-IKDDIRSLKS-KQKDLENR
IESAKQETENCLNSIL-KSKSSTEK----HVKF-SLPVEEVPATSEVPKPTQESAAVGKS
GGDQETNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLNVQESMQNAQDEREVNELQNQPL
ELDIMLRNEQLKGMEELYTHLEARRAATELLKQSQHLNQTEEQASVLPTARPSACHLGSL
QQELHTLKKTKERQYGLLNGFQDQLVEAEASLNTFLAEVESLKV-GSLDSATYLGKIKKF
LGSVEKQKGSLSKLHTEWAHLSSLLTAADQKLVESQMKQLEHGWELVERLAHRKCFQQAT
EHSELTCLLKKAQDLQVSL-H---QQQQRLTLSLDSPEQQAAIVDMVTPAAELQAIKYEF
SGLKRQAELHMKRLWGGKDKKTLEDAINNLNKQLEAL-EPLNREVE-----NRVKKCDLQ
NRIKETLSWVKNTLAELLVPIALLPDNILSQIRKCKLIHDGILGKQQAVELLVEEVRGIT
PSLAVCECDGLTTLLEDLQSQHQALLLKSTQRSQQLELKLEEKSKLFAIIGKAQLTLEES
ETLVSPTGDRAS-TEAELEHRLAVLKASQQQLQDMESALSAHLQELTNAYKDANVFERLF
LDDQLKNLKARTNRTQRFLQSNCSELKHKIESYREFHDKVAVLQKEVES--VLPGGLLLL
HQ----ELGQDAKGQLGNLRDKLAAIRGSISQVLISEEVFDSIGLSWDGSLLE---QLQT
QVLEREREIEEKIKQLDTFLIARDRHQASISKIRDVDLQIKKGAESLLKVPSTSP-ESTL
LNAQTLIRKIERSKRLHDEMIRELSENEAFDISFKESEMQQLKLNAEENSRLQEAL-QNM
LLELQPKEMGKKEFQEKLENALHVLKQIKSQLQEPLCVNLGVQHIQHEKETWEAFGEQIE
AEMCGLRAVRISGEQRE-ENDS-ATGGMEAKLRDIEGLHMELRESIDLRTDVLNDAYDSA
TRYDELVAGASRIVTSLEAMLLSYRVDLHNPQESLELARLK-QGELESALADLRSLTETL
GAISSPEAKEQLHCTLGALAATSSALKAGLEAQEAEEE--RCL------ENYKCYRKMKE
GICSRLRKMEMDLRQSIAPLPRSYKEALSRLEQSKALTSNLLSTKEDLVKLRQLLRHLRS
RSTENDATCVLGVASALWEKWLSLLEAAREWQQWSGELKREWKFISEEIEREAIILETLQ
EDLPEISKTKDAAPTEELWQLLDSLCQHEESVEKQQLLLALLLQRVRSIQNIPEGTETRE
T-IPALQEIGSMQERCDRLLQTAQKNKDLVQAEIQAQQSFIKEIKDVKRVFEQISTSFPN
LASEGHPERAEQFEELQSILQKGKLSFESIMEKLRIKYSEMYSIVPAEIESQVEECRSAL
EDADEKMSSEVSKNSPSSVMRKKIERINNGLRYIEKMLQQKSRNIEEAHEIQKKIWDELD
LWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYSDLLKSTEAWIEKTSRLLANPACYDSARTLSHRASTLQMA-LEDSEQKHSLLHSIFTD
LEDLSIIFETDDLIQ-TIHELRDQVAALQQQIVEALPHVQQVADDVVAIESEVKSMEKKV
AKIKAILL-SKEIFDFPPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVFQRTSQLLQDVKLLENVTQEQNEL
LKV-VIKQTAECDEEIDNLKQRLTNYSAEISPEHVSQDQVADLPSLQG-EIESLENQILS
LNQKKEDLLVDLKTAVLNLHEHLKQEQQEVGDKPSA----GT-SECTVAER-DASERKL-
--SRTNSMSFLPVVKEEAEESSLKSEDGHRRTELPSAS--WSLLGKHCKDL-EGDGA-SS
SSATIVQD----ADGRISTCDSSMVHVIAPDSGSTE---QGPEPSPRLSQTEEGATPPIE
AALLDFPREQG-AFEATV--ERSGPQPADVLRVCKTQVAKLELWLQQASVAFEPETVDAD
MQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGTTHHEAEALSWKLKTVKCNLE
KVQTML-QKYSEDQ--HSSALKKP--S--EPHAVDYPASLSGLESVTTERPKFSRQKDVP
QPQ--TLELKPSEQRDLIKFTELN-AKKTWLQCHQENEDA-NRQSAS----------SSK
DPSPGNVTSDPALPPQAQ-SGDRWQY-----L-HHELTSRLNPPVP-QLVEPQVALTTSS
LPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEEAYISLDKRLFELFLSLS
RCLGSVEELLQRPGLLREDASAQQVFF----EKLALELKKLYLALGDKKDDFVKAVTWPG
KEATLLSECIDALKVSLESAQSRAAWRGASLKAGLDHSCSYQNEIKRLYSQLIKKKTVLQ
QSLNEVSGQSIGKQLQKVDMHTAELQNSERQVAKLRDEGERLRFPHGLLQDVYKLEDVLD
GMWGILRVRHLELSSPFLSKSLQ-TLLQGMAELVSIGKEKLATDPLQHTKSRAALQVQLQ
DHKRFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVSALEEEACLRGAQLQSML
QKWEEFDDNYASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLYQ
TLNEGKQLAASVSCPEPEGQIAKLEEQWLSLNKRIDQELHRLQTLLKHLL------SYSR
DSDELTQWLESSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISW
MNAVEPQAVGEDAELSQSSSSQVKHLLQKLKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTAFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKIQNLNSWLEAQEE
RLKMLQKPESAVSMEKLLLDCQDIENQLAMKSKALDELRQSSLTMDG-GDMPLLEDMVSG
IDELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAA--L
SLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASC-PSIAGIIEEKCQDAH--SR
WTQVNQ---DLADQLQEARGQLQLWKAPHNAHAEAAAWLQQQETKFQQLANTNMSGDNLA
DILPRALKDIK-GLQSDLRKTKEAFLENSILSDQLPQ-PEECSTPGLHSGQRHCLQTAAY
LEKMLLAKSNEFEIVLAQFKDFADRLAYSKDLI-VHEEENLNKLYHEEK--EGVPDLLLN
SVLALTAQSPDIECLNEESLRLPLGDITIKTLQSVNRQWIRATATAL-DHYSELQGNGLN
-EK-FLYYCERWIQVLEKIQESLSVEVAHSLPTLLEQQKTYEILEAEVSINQTVADAYVA
QSLQLLDTAEIEKRPEFVSEFSKLSDQWQRAARGVRQRKCDIGWLVTQWRFFI-TSVE-D
LLRFLADTGQLLSAVKEQDCYSLCQTRRLVHELKSKETHLQRWRTTYELALEAGEKLRD-
-TPNPETREFIDGQTSRLQDTWKDTELSLGELISRLQSTA-ETWDQCKKKIKKLKTRLQA
LKAQSEDPLPELHEALHEEKELIKEVETSLANWTHSLKELQTMKADLSQHILAEDVTVLK
EQIELLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSI
EEMIEKLQ-----------------------------------------------KDCME
EITLFTENK-LQLKQMGDQLIKASSKAKAAETEEKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDNQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIED--PREIQADSWRKRRESEE----
PTSPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISEGHP------
------------WHVPDSPSHSKHHYKHMEGDRTAAPVPADASTPYKPDYVKLLLRQGT-
DDSKED---LKEAQ----Q-ED-EQLTTLTG-QQ--PGAFDRWELIQAQELHSKLRLKQT
V---QQLESDIGSIAAWLGKTEA-ELEALKLAEPPSDIQEIALRVKRLQEILKAFNTYKA
LMVSVNVSHKEYLPSQSPEATE--LRNRLHQLSLSWDSVQGVMDSWRGDLRQSLMQCQDF
HQLSQDLLLWLATAESRRQKAH-V-TSPEADRQVLLECQKELMRLDKELVAHQPQVSSLQ
EISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLREQVAQDLMSLQGSLDPDA-SLTS----
--FD--EVD-SGE-QLPAAFAKQFGA----------EEEEEEEETD-------SRTPHLD
SPS-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSTVAPAEDQ-QV-AVGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSAVSDLFTDIKKGHVLLDLLEVLSGQQLPRDKGLNPFQCRINIEHA
LTFLKNRS------IKLINIHVADIIDGNPSIILGLIWTIILH FHIE----ELARTLSCN
YNE-----PAAAEVSVV-D--SSPTSSPPAKKCSK--AQERWKLSA KKALLLWAQEQCAT
-YES-VSITDFKSSWRNGLAFLAVIHALRPDLIDMTSAKQRSNKDNLQEAFRIAERELKI
PRLLEPEDVDVANPDEKSIMTYVAQFLQYSKDAPVTRDEAQG-ETKAAM--------DWL
ARQEKKLQKALKDSEHEPYFKKYHS----FLSFLESFDEEKKPFLDLLPLTRPPDELSEE
ELRLRGDWDGLNQQINTWKTELNQALPSPLCHIEGWLQELEELVGEELPASQNYSEAMIL
TQEKMTLFKSLMDRCDSNSNTLMAFENRDEKHLPLVPPNKLEEMK-RRL-NNILERRFAL
LLEFHYYKCWVLGLLEEVKSKLDVWNVRYGNKASVELLQEDWHKFIEEKGFLVQLDTSFQ
KCEEI---YKH------LAGECQNINEQYTVMESNICMYKKYLYNVKSTLQKVLASWATY
MEKLRSLKACFEETKKEQIKE-----VPFEILSQWNVEHITLNEVGNFLIGVSNDEVGAS
ISKELRRLNKRWRKFISKTQLEMKLPL-I-KKQDQPIPDTSGN----------I-LPSKE
EKPTADVLTDASTELSGDHDW--NIR----------------------------------
--------AGGEGEKEKEEFLGQLKVAEEVEKLSGR------VEIWEAETASVLDLLRQG
DDAG--TSMEEPLQHLLAKGSMYEELVARTEDTLQMDIQNISSQES---LQHVLTAGLQA
KIQE-AKEKIQINVVKLMAASKTSSDV-SAGLDARLQLEESRKELESHMAKAEQLLEQRE
RPGALISKYKEALILLNTKCMAKYLRAVEEMKGSVTEDVQLSWEEESRAVCAKWESLHHE
LSLYIQQLKIDIEKGKLSDTISKLEKQINKEKKLIRRGRTKGLLQEHE--ACFSKEGILP
QLHQHMDVLRELCEE-LP--SQHSQQEGKRALRDYEQKIERLLRCATEIHATL-----QA
TVG-DP--SGNKGTVATTENGGGDSHGEVPFAKPDHQPPTEQ---V-MEPA-NFVPASEA
KPQQEASVTEQHEKEHSLTLDSLQKRYVTQKEILELHLQSNKFRITSAFSSENEQSSACL
RDKLTDLQ-GLKNETDAYWKEFEITSLKLENLVSDVEKP-AIVKARDGLKEKEGELHLTL
HARLKSLETALQTVSPVERETVFLCGLD-LSLPEIVIQDFHLVNADGIYQHLRD------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSVAKQIEICNE---ELDSFASKELH
PSDVQAAQNITLTCKAQLEGMSHKVQTRDGALRALEDFLECLGTAKPSAEGT-ADRPAEQ
NPEAPGNASNAENEVGATQLLKDRARHLDESLEVLGVSLKDVQQGEDTSCEKLLEASSLR
VLGSCGSSPREELTEEARLLEA-------CILRNNELFKNIQDVQSQIGKLGLKDPTIPA
VKHRKKSLIRLDKDLDGYEEEKKHLQELALSLPQFHDGRELVLSQQCHRTVRLWENTKAA
LAECLEQCGRVLELLKQYHNFKSSLTTLIQKEENAISLQASYMGRENLKKRITEIETIKE
EFNEHVEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDHYENLG
RALALWDKLYNMKNVCDEWTEEVVQKMELHPLTAEDRDRLEEELQVHEQKVAEFSRRVAE
IQFLLQSSEKPLELQVMESSILKQMEQVKQCLTGASSCSALADNAAELREDLDQAKTQIG
VTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMTVLETQVGCMTPELAELKKQYESVS
DLFTAKKSVLQDHFSKLLNDQCKNFNDWFSNVKMNLKECFESSETKKNVEQKLQKLSDFL
TLEGRSSKIQQVETVVRHVTKHLPHARVAELNSWLLSQELELGQMESVCRARAKELAELL
QQLLRLQDDHRNLSKWLTNQEDKWKEMQESGEKAELFCQALARKREQFESMAQLNNSLKE
QGL-TEE----EDIIMESARLIDKYQTLLRQGHRIEEEAQLAPAEDQGFNDLAHDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTLLREAG------SSEALS
V--QETLGDIRSQWDSTLHLASTYLSHQEMLLLEGEKYLQSKEDLRLMLTELRK-KQEAG
FALQHGLQEKKAQLKICKKFLEKAQDLTSLLKELRAQGSYLLQCTNNPSFSEEPWLEIKR
LHQSLLQQLQDSVQKLEGHVQEHQSYQVCLTESNAALDSLSKELASFADQPVDRIAVEEK
L-QKLEEFQHQLSLQGGALDKISALAKSVKQNTSSVGQKI-IKEDVKSLQH-KQKDLESR
IESAKQEAESQLHSAHLQLQRAKEG----TGEL-TVPGGEQQEGS-----PEEAAAVGKL
EEDG--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------DINK--NSAVEMILSKQLSLGVQESMKNSEDEQKVRGLQDQPL
ELDVVLRNEQLKEIEELYAQLEAKRAAIETLAE--------ASALGLHDTGDPAQHLDTL
LQALATLKEDRESQYCLLADFQGQLSVAATSVKAWLAEKENLKG-GSLDIAAHLDKIKKL
LASIEEEKGLLSKLKMEWENVSEHLTGMDQKLLESQMKQLERGWEQVEQLLQKKYSQRAV
ERDAFASLVSKIRDLEMSL-Q---KQQQRLRSRLSSAGAQEGDQSVVASATELQTLKQGF
SVLKGQAELQMKRLWGEKDKTILEDAINNLKSQLDAL-EPLSLEVE-----NQMKKCEMS
SEVRETILWVKNLLGELVHPVSLLPEDILSQIRKRKVTHDSILEKQQAVESLAEKVKDHI
SNLPADESSDLQYLLEYLQNQYQMLVLKSTERSQQLECQLEERSRLFAVIGKVHSTLQES
EMLMTDKMGATC-TEAELGRHLVTLKGSQEELQEVERLISTQLPELATISEDLNVFERLF
LDDQLKNLKTRVSRTQRFIENRCGEVEHKVKFFREFQEKISVLQKEVDD--LQHKELL-L
TQ----EINQDAKQEFRTLKDRLAGIQCGVLQMLKLKEVFEIMGLEWDHSRLD---QLQS
QVNEKEKELEEQMKQVDLFVTARDKYQESLDNMRAVDLHVENRAEGLLNAPGASP-ESCL
LQAQILDQRLEKTKCSYDDLMKQLTESEAFDDSFKEKEIAHIMQKAEEKDNLRKLL-QNM
ISHFQPKDTDEKNLQDRLERSLRLLNQIERQLQQPLLIHLDVAHIQNEKDNCEAFWEQVQ
AEMCAVRAVAVPETQREERTPP-ESRGVHATLRDVEDLQRQLRTSIDLRKNVLSDAHENV
IRYNEAVTRAVGIIASLGATCASHPVDLDNLEESLAAPRRK-QEELESTLADIQGLAERL
GTVCSPQAQRQLQCTLQELVAKKSALQEAARGADAEQA--RYL------QNYKNYGKIKE
KICANLKKMGTVLGQSISPLPVSYKEALERLEESKVLVSNAESAEEDLLELRQVVRRLSA
RCTEGDRVHLQRILLALWEEWLRLLEAARAWEMWCETLKQGWKFVSEEMEREAIILDNLQ
EELPEVSKTREAAPKEELCELLESLSQCEQHVEKQQLLLNLLLERMKSVQNVPEGPGAGT
T-TPALQEVTSMHDRCNRLFQKVQKSKELMQTEIQERHAFTREIVALKHLFQQTATSFQN
A-TQEHPLKAEQLEELQSILREGKRTFETLMEKLRIKYSEMYTIVPAEVGSQVEECRRAL
EDTEEKISNEVLKSSPSYAMSRKIEEINSGLQNVEKMLQQKSKNIEKAQEIQKKTWDELD
LWHARLNELDAGIHHMVEQDPVQAQEWMDHLMIPLQRYQQVSQRAESRTSQLNKATIKME
EYSELLKSIEVWVENTSRLLANPADYDSAKTLSHHASTLQMA-LEDSEQKHSLLHSVLTD
LEELSTIFDTDDLTQ-SIQGLSSQITALQQKLLESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILDNLRPMKKTIAEIVSYQVGLRLPQAGRGPLPVFQRTSQLLQDLKLLENVTQEQNEL
LKA-VIKQTDEYDEEIQKFQQILSDHADDVSREHTSVGQAAHLPQAQG-EVEQAQKQILS
LNQKKEEVLVDLKTAVLTLHRHLKQDQEEGE--RQLLPAGAS-EEGGVAEG-DISEWQV-
--NPRGSMSFLPALKEEVEEGSVKSETGDKKAEPSSAS--WSLPWKHGEEV-EEDRA-SS
SSATLVQE----VNGKISTCDSSMAQILVPATPNTE---QGPEFSLRPGQTEEGAAPPIQ
VLNFSEEPGA---AGATV--ERGGPELAEVLHACRSQVAELELWLQQANVAFEPETLNAD
MQQVVEQELVGCQAMLTDIEHKVASLLETCRDQSLGESGAIQYEAEALSLKLRTVKCNLE
KVQMMLQEKYSEDQ--HPTILKKP--P--DHQGVLQPGDLSELERTETERPQFHRQKDIL
EPQ--VMELKPMEQKDLIKFIEFN-TKKMWPQDCQHEKDP-TQESSM---------SN-R
ASSPENDAPDSVSWPQGR-SGGRWLY-----L-HRKLSSRTRPALP-QLVEPQVATNTSI
LPSVSVYNFKYPTTEELKTYTTQLEDLHQEASTLQTQEPMTEDRCSGLDKKLFELFLPLS
QHLDLVEELLQMPGLVREDVSAQQVHY----ETLALELKKLYLSLSNKKGDLVKAVTWPG
RNTSLLLECLEQLQACLEHARATAVSRGKSLKAGLDYKRSYQSEIKRLYDQLTQKKTSLQ
QSLNEMSGQAVGEQLQKADACTAELQNSESRVAKLRAEGERLHLPWALLQEVSKLEDVLD
SMWAILRSRYSALSSPFVSESQQDALLRGVEELVRIGKEKLSHDHLQPAKSKAALQAQAQ
SHKVFFQKLLADMLFIQTYSSRVSP-LSQKREGFWAEQVAEVKLLEEESRQRGVALQSLL
QKWEAFDENYACLEKDLEILLSTLPSVSLVEETEERLAERISLYQQIKRNVDGKHVRLYQ
TLNEGKQLLATVSCPELGGQMAKLEEQWLSLDKRLDRELHRLQTQLKHLR------SYNR
DSDELTRWLGSAQQTLNHWKEQSLNVSQDLDTVRSNISRFFEFTKEVDEKSSLKTAVVST
GDQLLHLKEADTATLRACLAQFEQKWTLLITQLPDIQEKLHQLQMEKLPSRKAITEMIDW
MDSMESAL--EGAELSPGSAAQVRSLLRKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTAFAEDLGEMNRRWHQVHGALNRKIQHLEQLLESVTEHENKIQMLDNWMEAQEE
RLRTLQRPEAVVSVEKVLLECQDIENQLEIKSKALDELRQSSLTLES-GGAPLVKDATSR
IHELFQKRARVTSQINQLKNSMQSVLREWKTGNRLCSEMEVMTVRFRYCLELGKPLI--S
SLEALGCQVQNLQALQDEAESSEGSWEKLQEVTRKLQGFC-PAVAELIREKCQAML--SR
WTQVNQ---EIAEQLQKAQSALQLWRTYHSAHSEASARLQQQEAKFQQLATINMSGNNLA
ETLPLALQDIK-ELHRDVQETREAFARSSALLDRLPQ-PAESSTHVFLSGQPHSLQRAAF
LEKTLLMKASEFEFVLSQLKEFWDQLESLQGL--MHEKENVDKLHQQER--EENPNSLLN
RVLALTAHSPDLERLNEVSLKLPLSEVAVKTLQSMNRQWIQATATAM-DRCRELQDAGLK
-EN-FLYCCEKWVRLLEKMEEKLGGSAGDSLAALLEEQKTFQMLEAEVSISQRVADVWVT
QSLQLLDTAEVERSPEFVAGFSELADRWLRAAQGVRQRAREAEGLVRKWWCFT-ASAE-E
LLRFLADTSHLLSALKGRDHYSLSQTRSLLQELKNKEIHFRRWQTTYALTLEAGGKLQD-
-MSDQESRASVGETMSQLQDSWTSTELQLGEMVQQFQGTL-EAWEQCGKKLQELKSRLQG
VKVQSRASLPELHEDLQKEKERIKDLEKSLATWSQNWQELEAVQAELGRRALAEDAMGLR
QQMEHLHRQWDDLCLRVAMRKQEIEDKLNSWILFNEKNKEVCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LRLKQMGDQLIQASNKTRAAEVDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDRNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLQ
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDAAS
KLKQMVHEGNQRXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXLDMATTQGSP
SCQHSILQTGIGVR-GFVGR-------------------------------------AGW
CDL-----------------CY--------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

-------MATSPALPTEDG-QV-SLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSAVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----ELARTLHCD
YNQPSSDIPSLDIVNAA-D--SSPTSSPPAKKSSKAQAQARWQL SAKKALLQWAQEQCAT
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSSKENLKEAFRIAEHELKI
PKLLEPEDVDVMNPDEKSIMTYVAQFLKYSRDAPGAGTSAQV-KVKDAM--------VWL
ALQEKKLQK-LKDSASETYFNKYHS----LLSFMKSLNEEKEPFVAVLSLEGS-NEPNED
QLRLRQGWAGLTHQVAVWKTQLDDALPSPLKETEAWLKDVEGLVEEGLPASQNHSEAVAL
IQGKMSLFKSLMASSDYHLNILLAFENRDEKQLPVVPPDKLEEMK-RRV-SNILGRRFIP
LLEFHDSKCAVLALLDEAKAKLDVWNVTYGNEESVAILLEDWRNFIEEKKFLAQLDTSFQ
KCEEM---YKN------LAGECENVKEEYVTLEKNVHACRQRLHNTKATLQRVLACWATY
KEDLLLLKASFEATKKEQIKEVFEVSVLLLFLETWNTKYASLNEVGSFLVDVSNGEVGSS
VSKELRRLNKRWRKFIPKTPLELNLPL-T-ENQDEPT--------------------GGS
PVMILCEGSAGPAEPHESHGE--DLK----------------------------------
--------GVGKQETEDDASTGQLKVNEEVEKLIKE------VKIWESETKTSLDLLRHA
DDVN--GSSVDALQHLIAKGSMYEELLTRTEDTLQMDVQSASNLES---FQNVLRAGLQA
KIQE-AKEGIQITMVELSAACENIAGE-SQELDARLKVEEAQKDLESHITKAQQLLGQRE
RPGGLVAKYKEALGIFNTNSLAKYLQAVEELKCNVPGDAKLHLEEQCQAARAKWEPLHHE
ISVYIQQLKIDIEEGKLRDNIAKLEKQINKEKKLLRRGKTRGLAKEHE--ACFSPDSVAC
QLEHPVGVLRVLCEE-LT--SPESQQELKRALGDYKQKIERLLKCASEVHMTL-----QS
SQA-GT--LKERGALTTPENGRRDAHSEALLETPDNQLPTEK---A-MEPVKNFSRTPEL
KPRQEGRAMEK-EGKDCSALSDLWERYDTQRDSLERHLQDSKSRLTSDFPSGRERSSACL
QGELAELQ-VFRADTNARWDELEATSLTLESLVSDMEKP-ALAQARDLLKEKEHELQKLL
NTRMESLEMALQIVLPLEKECALLCGPH-LPFRTVTVQDLHPVKVDGIYQNLQD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIRQCANL-EEPRDSVPMDLH
TLDQRAIQDIVPKCRLQLETMNQKVEMSEDALKALEDFLASLRAAKLPEDPP-AANAAEG
TL------------AEDILLLKEKARPLDERLRMLGINIKDAEGGQFTTCEELLGALSVK
VSDSHGQSKQEGLTEDKTLLEA-------CSSRNYELFKNIQDIQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLDGFEEEKMRIQQMANSLPKFKDGQEKMVIQQCQDTAALWESTKAS
LTECLEQCGSVLELLKQYQNFKNNLAALIQKEEAIISQQASYMGRDNLEKKVAEIETVKE
EFNEHLEVVDKINQICKNLQYHLNKMKTFEEPPFEKEANAIVDRWLDVSEKAEEYGENLG
RALALWDKLFNLKNSIDEWTEKILGKLESHQLTEEDRERLEEELKVHEEQASEFSRRLAD
IQLLLQSNEKPLELQVMESSVLSKMRDVKRFITGDSNSYVPSGNTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMTVLENQIGCLTPELSELKRQYASVS
DLFHTKKSALQDHFSTFLTDQCKNFNDWFSNIQMNLKECFEPPETKLSMEQKLQKLSDFL
TLGGGTSQIQQVETVLQHVKMLLPKARVKELNSWLGSQELELENLESACQARARELTDSL
KQLLR----------WEIN-------------NTDLFYQALTRKREQFESVARMNNSLKE
HGL-TGG----EETIKESTQLIDRYQTLLRQLHEIEEEDKSAPTEDQSFNDLVHDVAHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIILLKSEGDAKIQMVMREAE------HCEAPL
V--QETLTDLSSQWDNTLHLANTYLRHQEKLALEGEEYLQSKEALRLMLADLKK-QQEAG
LALQPGLPEKQAQLKICKKFLQKAQDLTSLLEELKAQGNYLLECTKNPSFSEEPWLEIKQ
LHESLLQQLQGSVRKLEGHVQEHSSYQVCITDLNTTLDNISREFVHLCDAAEDHMRAEDR
M-QKLQELECGLRCQGGILKKASALANSIKQNTSSAGQKM-IKDDIKSLKY-KQKDLENR
IESAKRDAENGLNSIL-QSKGSTEK----HAKS-SLPGGEMLGTCDAPKPTQESAAVGES
EGNWETNK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLNVQESMQNTQDERKVNELRNQPL
ELDIMLRNEQLKGMEELYAHLEARKEAIDLLDQSQHLSETEGRALVLSTAKSPAYHVGSL
LQALLTLKKTRESQYGLLNGFQDQLVAAESSLNTFLAEAESLKA-GSLNSTTYLGKIKKF
LGSVEKEKVSLSKLRMEWDHLSSLLSPEDQKLVESQMKQLEHGWELVEQLAHRKCFQQAT
EHSELTYLLKKAQDIGVSL-H---EQQQRLQLSLNSPEQQEESLGMVAPAAEIQAIKYEF
SGLKRQAELQMKRLWGEREKETLEGTLNNLNKELEAL-EPLNREAE-----NRIKKWDLK
KRVKETLLWVKNMVAELAAPISLLPDDILAQIRKCKLIHDGILGKQQAVDVLVEEARGLI
PSLAACERDALNTLLEDLQNQYQALLLKSTQRSQQLELKLEERSKLFAVIGKAQLALEQG
ETLMVPTREKAS-TEAELERQGAVLKASQQQLRDMESVISARLQELTNAYKDADVFERLF
LDDRLKNLKTRTSQTQRLIQNSCNEMERKIRSQQEFREKVAVLQREVES--LQLGELLPL
HQ----EPHQDAKAQLCHLKDKLAALRGGISQVLTSEEVFDSEGLAWDGSLLE---QLQT
QVLEKEKELEEKIKQLDIFLIARDRYQALLSKIRALDLQIKKRAKSLPKVPNMSA-ENTL
LNAQILIQKIEKAKCLRDELMKKLSKSEAFDDSFKEREMLQLKLNAEDNARLQEDL-QNM
LLELQPKAMDEKALQDKLENSLHVFKQIKSRLQQPLCVNLGTQHIQNEKETWEAFGEQVQ
AEVCGIRAMRVAEEQRE-ENSS-RTSDMEAKLQDLEGLYVELSKNIDMRTNILDDAYENA
TQYEELVTRAAGIIASLETTLLCYRPDLHHPKESLEPAHRK-QEELQSTVAEIQNLTETL
GTISSPEAKEQLLGTLQDLVSKNSALKAGLEAQEADDR--RCL------ENYKCYRKMKE
EICSRLRKMETDLRQSMSPLPRSYKEALAGLDQSKALTASLLSIQGDLVSLRQVLRHLRC
RCTESDGACVLRVASALWEKWLSLLEAARVWQQWSGDLKREWKFISEEIEREAIILESLQ
EDLPEVSRTKDIAPTEELRQLLDSLCQHEGGVEKQQQLLTLLLQRITSIQNIPEGTETVE
T-IPALQEIRSMQERCNRLLQATQKNKDSIQTEIQARHSFMKEISDVKRSFEQIVTSLQN
LAREDHPERAGELEELRSVLEKGKLTFENIMEKLRIKYSEMYSIVPAEIDSQVEDCRKAL
EDADEKMSHEISKSSPSCVMRRKMEDISHGLHCIEKMLQQKSKNIEEAQEIQKKIWDELD
LWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQRHQQVSQRAESRTSQLNKATIKME
EYSDLVKNTEAWLEKTGHLLATPACYDSSKTLSHRASTLQMA-LEDSEQKYNLLHSVFTD
LEDLSLIFETDDLIQ-SIQELSGQVAALQQQIVENLPHIQQVADDVVAIESEVKSMEKKV
AKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIHAMKKTIAEIMTYQMELRLPQTASKPLPVFQRTHELLQDVKLLENVAQEQNEL
LKV-VIKQTAECDGEIENLKRMLNNYSAEFSPEHVSREQVADLPSSQG-EMEGLEEQILN
LNQKKTDLLVGLNAAVLNLHEHLKQEQQEGGEGDEL----PS-EEGGVTEQ-GVSGRKL-
--TRTSSMSFLPVVKEEVKESSVKSEDGHGRAEPPSAS--WALPWKHSKDL-EEDGA-SS
TSATIVQE----ADGRISTCDASMAHIIAPDSGSTE---PGPEPSPRLSQTAKGATPPIE
ASPLDFPHEQG-AFEATV--ERSRPQPAEVLHVCKTQVAELELWLQQANVAFEPETLDPD
MQQVVEQELAGCQAMLTEIEHKVASLLDTCKDQGLGDCGATQQEAEALSWKLKTVKCNLE
KVQMMLQE--NQFQ--HPTTVKQP--S--ESHTVFQPVSFPEFESVITERPQFSKQKDVP
QTQ--VLALKPLEQKDLIKFTEFN-AKKTWLQYCQQDKDE-NQESAP----------SGE
VPDTGNVAPGSALSPQGQ-SGDKWLY-----L-HHELTSRPNPPGP-QLVEPQVATNSST
LPSVSVYSFRCPTADELHTYTTQLEDLRLEANRLQTQERMTEETYINLDKRLFELFLSLS
RCLGSVEELLQRPELLREEASSLPVFFPSILQKLALELKKLYLALGDKKDALLKAVTWHG
RDTTLLPECFDALKVSLERAQEKAARRSSSLKAGLDHSCSYQNEIKRLYNQLIKKKMALQ
QSLNAISGQSIGEQLQKADVHTAELQNSERQVAKLRNEGERLCFPHVLLQDVYKLEDILD
SMWGILRAKYLELSSPFLSQSQQDALLQGMVELISIGKEKLASSPLQHAKSKVALQAQLQ
DHKGFFQKLVADMLLIQTYSAKMSPPSLQKGERFEAEQEAEVRALGEEACLRGSQLQSVL
QKWEEFDDNYASLEKDLEVLVSSLPSVSLVEETEERLLERISLYQQIKRNIDGKHLRLCQ
TLNEGKQLAASVSCPELEGQITKLEEKWLSLNKKIDHELHRLQTLLKHLL------SYSR
DSDELTRWLESSQQTLNYWKEQSLNVSQDLDTIRSNIDRFFEFSKEVDEKSSLKSAVLST
GNQLLHLKEADTATLRSSLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRSAISEMISW
MDAVEPQAAGEDAELSQRSAAQVKSRLQKLKGFRMEMDYKQWIADFVNQSLLQLSTCHVE
SKRYERTEFAEHLGEMNRQWHRVHGALNRKIQHLEQLLESITENENKIQNLDSWLEAQEE
KLKILQKPESAISMEKLLLDCQDIENQLAVKSKALDELRQSSLTLEG-GDIPLLEDMASG
IDDLFQKKNNVTSQVHRLRASTQSALQEWKAFDKLYDEANVATIQLAYSMEHSKPAV--L
SMEALDCQVQSLQALQDEAESREGNWEKLREVIGRLEDSC-PPIAGIMKEKCQDAH--SR
WTRVNQ---DLADQLQEARSQLQLWKASHSAHTEAAARLQQQEAKFQQLANINMSGNNLA
DILPPALQDIK-ELQHDVLETKEAFLANSTFLDQLPQ-PADPSTLGLHSGQLHSLQTAAY
LEKMLLAKSNEFEIVLAQLKDFGDRLDYLEDLI-MHEEENLNKLYHEET--EEIPGSFLN
HVLVLTAQSPDIERLNEESLRLPLSDITIKTLQNVNRQWIRATATAL-DHYSKLQGNGLN
-EN-FLHYCEKWTQLLEKMKETLAVKVAHSLPALREQQKTYEMLEAEVSINQTVADAYVA
QSLKLLDTAETETRPEFVSEVSKLSDGWQSAARGVQQRKGDIDRQVARWQFFT-TSVE-D
LLRFLADTGHLLSAMKKQDCHSLYQTRRLIHELKNKEIHVQRRRTTYELALEAGEKLRN-
-TPSLETKEFIDRQVTKLQDAWKDTELSLGEMISQLQTTA-ETWDQCEKKIKELQSRLQV
LKAQSRNPLPELHEDLHREKELIKEVEKPLANWTHNLKELQTMKADLSRHILAEDVTVLK
EQIELLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EISSFSESK-LQLKQMGEQLIKASSKAKAAEMDDKLSKINDRWRHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDHEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPSLEDEKEASENETDIED--PREIQADSWRKRREMEE----
PPSSQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----DEGPFYSAL-----------------------SGKSIAEGHT------
------------WHVPDSPSHAKHHYKPVEDDRTVAPVPSDASTPYKPAYVKFLLRQGT-
DDGKEG---PRGSKGSPQQ-EG-EQLDTLTG-QQ--PGAFDRWELIQAQELHGKLRIKEN
T---QRLNSDLGAIAAWLEKTEA-ELEALRLAEPPSDVQEMSLRVKKLQEILKAFATYKA
LMASVNVSHKESQPSESPESTE--LQNRLHQLSVSWDTVQGVMDSWREDLRQSLMQCQDF
HRLSQDLLLWLASAESRRQKARVV-ASPEADREVLLECQKELMQLEKELEDRQPQASSLQ
EISSGLLVKGHGEDSIEAAEKVHVIEKKLKQLREQVAQDLKSLQERLNPDP-SLAS----
--FD--EVD-SGE-QPPAASVPASYAKVSAL-----PSLKKYPEWL-------SKMSHLN
GPS-SSQPKRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MAASPVLPTEDG-EG-FLGIDDLHF-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHTPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVADIVEGNPSIILGLIWTIILHF HIE----KLAQTLSCD
YNQ-----PSPEVVSVA-A--SSPTSSPPTKKCSKAQAQARWQWS AKKALLQWAQEQCAR
-SES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMDSMRHRSNKDNLKEAFRIAEHELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLKYSKDAPGPGDSTQA-KVRDAL--------VWL
TLQEKRFQKMLKDSASETYCNKYHS----LLSFMESLNEEKESFIDVLSLKGRMGELNED
ESRLRQGWTSLMHQVAAWRAQLDDALPSPLKETEAWLKDIEGVVQEGVPTSQSYSEARTL
IQGKLSSFKSLMGSFDYHSDVLMAFQSNAEKSLPAVPPVKLEEMT-RRI-NNVLGKNFIP
LLEFHDSKCSVLALLDEAKAKLDVWNGTYESKESVEVLLEDWHKFTGEKKFLIQLDASFQ
KCEEM---YKN------SARECESIREEYMMLEKNVHSCRQYIHNTKATLQRALMSWATF
EEDLALLKASFDLTKKEQIKE-----VPVETLLQWNTKHTSLNEVGSFLIGVSSREVAAS
ISKELRRLNKRWRKFITKTPL-LKLPL-V-KIQDQPPGNSSGT----------S-L-SKE
--------SAMAAEPGGSRGE--DVK----------------------------------
--------AAEKQEVEDEESAGQLKVNEEVEGLIKQ------VTIWESQTKSILDLLQHG
DHAD--GSSADTLQHLIAKGSVYEELLARTEDTLQMDVQSPSNLEP---FQNVLRAGLQA
KIQE-AKQGVQITMVELSAVLKNLSDE-PLELDLGLKVEEAQKELEVSILRAEQLLGQRE
RPGGFLLKYKEALEILNTNSLAKYLRAVEELKRTVPGGAKLQLEEQSRVASAKWEPLRHE
ISLYLQQLKIAIEEEKLRDNIARLEKQINKEKKLIRRGRTRGLRKEHE--ACLSPESIKC
QLEHHVGVLRVLCEE-LT--SPEDQQELKRALRDYEQKIARLLKCASEIHTTL-----QS
SQG-GA--LEERSALITTENGRRDADGEVPLEIPDNQLSTEK---A-MEPIKNFSQTSEL
KPQQEESIMEKEGKDCSASLSDLQERYDTQRGLLEQHLQDSKSRVTSDFASEQERSSACL
QSKLAELQ-VLLADTDAHWEKFEITSLNLRRLMSDAEKP-VLNQERDLLKGNEQVLHGLL
NTRMESLEMALQIVLPLEKECSLLCASD-LPLCTVAVQDLHPVEIDGVYQNLRD------
-IR---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQIRVCTSL-EEPSNSVPRELH
TLDQCAIQDIVLKCRLQLETMNQKVEMREDALDALEGFLASLRAAKLSAELP-ADRP---
APKAPE------VLSEDILLMKEKAGPLDERLRTLGINIKDAEGGENTTCERLVGALSVN
LVAMDGQSKEEGPPEDKKLLEA-------CSSKNLELFKNIQDLQNQISKIGLKDPTAPA
VKHRKKSLLRLDKDLDGLEEEKVRIQKIAGSLPRFKDGSEKNVIQQCEDTAALWESTKAS
VTESLEQCGSALELLRQYQNIKNNLTALIQKEEGIISQQASYMGKDNLKKKIAEIETVKE
EFSDHLEVVDKINQICKNLQYHLNKMKTFEDPPFEKEANAIVDRWLDINEKTEEYGENLG
RALALWDKLFIIKNNIDEWTEQILGKAESHELTEEDRGRLKEELKVLEEQSAEFSRRVAD
IQSLLQSNEKPLELQVMESSVLSKMKDVKTHVAGGSNSYAPSGSTAELREDLDQAKTQMG
MTESLLNALSPSDSLEIFTKLEEIQQQIFQQKHSMTVLENQIGCLTPELSELKRQYASVS
NLFNTKKNALQDHFATFLNEQCKNFNDWFSNVKTNLQECFEPPETKLSLEQRLQKLSDFL
TLGGGNSKIQQVETVLQHVKMLLPKAHVKELDSWLRSQELELENMESICQARAGELNNSF
QQLLRLEDDCRSLSKWLTNQEENWGKMEVSGERMDLFSQALTRKREQFETVAQLSDSLKE
HGL-TEG----EETIKESTHLIDRYQALWRQLHEIEEEDKLPAAEDQSFNDLADDVIHWI
KEIKESLMALNSSEGKMPLEERIQKIKEIIALKPEGDAKIQMVMRQAE------HCEAPL
A--QETFTDLSNQWDSTLHLANTYLSHQEKLVLEGEKYLQSKEDLRLMLTELKK-QQEAG
FALQPGLPEKQAQLKIYKKFLQKAQDLTSLLEELKSQGNYLLECTKNPSFSEEPWLEVKH
LHESLLQQLQDSVQKLEGHVQEHSSYQVCLTDLSSTLDDISKEYFSLCDGSKDQIMAKER
M-QKLQELESRLRFQGGALKKASALAKSIKQNTSSVGQKI-IKDDIRSLKY-KQKDLENR
IESAKQETENGLNSIL-KSKSSTEK----HVKF-SLPVEEMPATSEVPKPTRESAAVGES
GGARETNT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMILSKQLSLNVQESMQNAQDEREVNELQNQPL
ELDIMLRNEQLKGMEELSTHLEARRAAIELLEQSQHLNQTEEQALVLPAARPSVCHLGSL
QQELHTLKKTKERQYGLLSGFQDQLVMAEASLNTSLAEVESLKI-GSLDSATYLGKIKKF
LGSVENQQGSLSKLRTEWAHLSSLLAAADQKLVESQMKHLEHGWELVEQLAHRKCFQQAT
EHSELTCLLEKLQDLKVSL-H---QQQQRLTLSLNSPGQQAAIVDMVTPAAELQAIKCEF
SGLKWQAELHMKRLWGEKDKKTLEDAINNLNKQMEAL-EPLNREVE-----NRIKKCELQ
NRIKETLSWVKNTMAELVVPIALLPDNILSQIRKCKLIHDGILGNQQAVELLVEEVRGIT
PSLAPCEGDGLNALLEDLQSQHQALLLKSTERSQQLELKLEEKSKLFAIIGKVQLTLEES
ETLMSPTGDRAS-TEAELERRLAILKASQQQLQDTESALSAHLQELTNAYKDANVFERLF
LDDQLKNLKARTNRTQRFLQNNGSELKQKMESYREFHDKAAVLQKEAEC--ILHGGLLPL
RQ----ELEQDAKEQLGNLRDKLAAIRGSLSQVLTSEEVFDTIGLSWDGSLLA---RLQT
QVLEREREVEGKIKQLDTFLIARDRHQASISKIRAVDLQIKKGAESLLKVPSMSP-ESTL
LNAQTLIQKIEKSKRLRDEIIRKLSKNEAFDDSFKESEMQRLKLCAEENSRLQEAL-QNM
LLELQPREMGEKEFREKLENALHVLKQIQSRLQQPLCVNLGVQHIQHEKETWEAFGEQVE
AEMCGLRAVRITEEQRE-ENDS-GTGGMEAKLRDIEGLHMELSKSISLRADVLNDAYDSA
NRYDELVAGALRIITSLEATLLSYRVDLHNPQKTLELAHLK-QEELQSSVADLRSLTETL
GAISSPEAKEQLRCTLEVLAAKNSALKAGLEAQEAEEE--RCL------ENYKCFRKMKE
EICSRLRKMEMDLGQSIFPLPRSYKEALARLEQSKALTSNLLSTKEDLVKLRQLLRHLRC
RSTENDATCALGVASALWEKWLSLLEAAREWQQWGGELKREWKFISEEIEREAIILETLQ
EDLPEISKT-NAAPTEELWQLLDSLCQHQESVEKQQLLLALLLQRVRSIQNIPEGTETGE
T-IPALQEIGSMQERCDRLLHTTRKNKDLVQAEIQAQQSFLKEIKDVKRVFEQISTSFPN
LAPEGHPERAEQFEELRSILQKGKLSFENIMEKLRIKYSEMYSIVPAEIGSQVEECRSAL
EDAEEKMSSEVSKSSPSSIMRRKIERINNGLHCVEKMLQQKSRNIEEAHEIQKKIWDELD
LWHSKLNELDSEVQDFVEQDPGQAQEWMDNLMAPFQQHQQVSQRAESRTSQLNKATIKME
EYNDLLKSTEVWIEKTSCLLANPACYDSSRTLSHRASTLQMA-LEDSEQKHSLLHSIFTD
LEDLSIIFETDDLIQ-TIHELSDQVAALQQQIMEALPHVQQVADDVVAIESEVKAMEKKV
AKIKAILL-SKEIFDFPPEEHLKHGE----------------------------------
-VILENIHPMKKTIAEIMTYQVELRLPQTGTKPLPVFQRTSQLLQDVKLLENVTQEQNEL
LKV-VIKQTAECDEEIDSLKQMLTNYSAEISPEHVSQNQVADLPSLQG-EMERLEKQILN
LNQKKEDLLVDLKTAVLNLHEHLKQEQQEVGDKPSA----GA-SECTVAER-DASERKL-
--SRTNSMSFLPVVKEEAEESSVKSEDGRRRTEPPSAS--WSFLGKHSKDL-EGDGASSS
SSATIVQD----ADGRISTCDSSMVHIIAPDSGSTE---EGPAPSPRLSQTDEGATPPIE
AALLDFPREQG-AFESTV--ERSRPRPADILRVCKTQVAKLELWLQQANVAFEPETVDAD
MQQVVEEELAGCQAMLTEIEYKVASLLETCKDQGLGDCGTTQQEAEALSWKLKTVKCNLE
KVQMVLQEKFSEDQ--HPSTLKKP--S--EPHDVDQPAGLSELDSVLTERPQFSRQKDAP
QPQ--ILELKPSEQKDLIKFTELN-AKKTWLQGHQENEDA-NRQSAS----------SSK
VPSPGNAASDSTLPLQAQ-SGDKWQY-----L-HHELTSRPNPSVP-QLVEPQVALTTST
LPSVSVYNFRCPTADELQAYTTQLEELRQEANTIQTQGSMTEETYISLDKRLFELFLSLS
RCLGSVEGLLQRPGLLREDACAQQVFF----QKLALELKKLYLALGDKKDDFLKAVTWPG
KEATLLPECIDALTVSLESVQSRAAWRDASLKAGLEHSRSYQNEVKRLYSQLIKKKTALQ
QSLNEISGQSISKQLQKADVHTAELQNSEKQVAKLRDEGERLRFPHGLLQDVYKLEDVLD
SMWGILRARYLELSSPFLSKSLQ-TLLQGMAELVSIGKGKLAADPLQHAKSKAALQAQLQ
DHKAFFQKLVADMLLIQTYSATMFPPSLQKGEGFGAEQVAEVRALEEEACLRGAQLQSML
QKWEEFDDNYASLEKDLEALISSLPSVSLVEETEERLLERISFYQQIKRNIDGKHARLCQ
TLNEGRQLAASVSCPEPEGQIARLEEQWLSLNKRIDQELHRLQTLLKHLL------SYSR
DSDELTRWLETSQQTLNYWKEQSLNVSQDLNTIRSNIDRFFKFSKEVDERSSLKSAVMST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSREAISEMISW
MNAVEPQAAGKDTELSKSSASQVKHLLQKLKEFRMEMDYKQWVVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKVQNLNSWLEAQEE
RLKMLQKPESAVSMEKLLLDCQDIENQLALKSKALDELRQSSLTMDG-GDVPLLEDMASG
IVELFQKKNNVTSQVHQLRASVQSVLQEWKACDKLYDEATMRTTQLTYSMEHSKPAV--L
SLQALACQVQNLEALQDEAENGERSWEKLQEVIGRLKASC-PSMAGIIEEKCQDAH--SR
WTQVNQ---DLADQLQEARGQLQLWKAPHNAHAEAAAWLQQQEAKFQQLANTNLSGDNLA
DILPRALKDIK-GLQSDLQKTKEAFLENSTLSDQLPQ-PEERSTPGLHSGQRHSLQTAAY
LEKMLLAKSNEFEIVLAQFKDFTDRLAYSKDLI-VHKEENLNKLYHEEK--EEVPDLFLN
HVLALTAQSPDIERLNEESLRLPLSDVTIKTLQSLNRQWIRATATAL-DHYSELQGNGLN
-EK-FLHYCERWIQVLEKIQESLSVEVAHSLPALLEQQKTYEILEAEVSTNQAVADAYVT
QSLQLLDTAEIEKRPEFVSEFSKLSDQWQRAARGVRQRKCDISRLVTQWRFFT-TSVE-D
LLRFLADTSQLLSAVKEQDCYSLCQTRRLVHELKSKEIHLQRWRTTYALALEAGEKLRN-
-TPSPETREFVDGQISRLQESWKDTELSLGEVISRLQSTA-ETWDQCKKKIKKLKKRLQA
LKAQSEDPLPELHEALHEEKELIKEVEKSLANWTHSLKELQTMKADLSQHILAEDVTVLK
EQIQLLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADVSI
EEMIEKLQ-----------------------------------------------KDCME
EISLFTENK-LQLKQMGDQLIKASSKAKAAELEEKLSKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDNQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRYFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDAEDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLDDEKEASENETDIED--PREIQADSWRKRRESEE----
PTSPQSLC----HLVPPAL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPFYSAL-----------------------SGKSISEGHP------
------------WHVPDSPSHSKHHYKHMEGDRTEAPVPTDASTPFKSDYVKLLLRQGT-
DDSKEG---LKEAQ----Q-ED-EQLATLTG-QQ--PGAFDRWELIQAQELHSKLRLKQT
V---QQLKSDIGSIAAWLGKTEA-ELEALKLAEPPSDIQEIALRVKRLQEILKAFDTYKA
LMVSVNVSHKEYLPSQSPEATE--LQNRLHQLSLSWDSVQGVLDSWRGDLRQSLMQCQDF
HQLSQDLLLWLATAESRRQKAH-V-TSPEADRQVLLECQKDLMRLEKELVARQPQVSSLR
EISSSLLVKGQGEDYIEAEEKVHVIEKKLKQLQEQVAQDLMSLQRSLDPDA-SLTS----
--FD--EVD-SGE-QLPAAFAKSPRPRWTFL-----EEEEEEEETD-------SRMPHLD
SPG-SSQPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEDDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASNQSSPSTEE-QA-SSEIDDLFL-----SLQ---------VQRECTQKKTF
TTWINSILAKHTPPSVISDLYTDIQQGHMLLDLLEVLSGQHLPREKGFNTFQCRSNIENA
LTFLRSKS------LKLINIHVADIIEGKPSIVLGLIWTIIFHF HIE----ELARTLACT
YNQ-----PSLDCSSTVD---SSPKARRSAKKSAK--IKERWKIS ATKALLFWAKEQCSP
-YGS-ISVTDFKSSWRSGMPFLAIINALRPGLIDLEKAKARSNKENLDEAFRIAELEFNI
PRLLEPEDVDVMNPDEKSIMTYVAQFLQYSRNMPET-EDMQG-KVTETM--------SWL
AVQRKKLATLLVDTENETYYQKYKE----MMSFMEAFNREKKAFLPLLSSKRNEAELRKG
QQQMREEWSKLISQINEWKAELDQMLPPPLDDIEAWLQKVEHLQAEDLPDLQDPFKAMSL
FSEIISIFKGLMNCFDSHLETLQSFENKDEKNMPLVVPEKLEEMK-RRF-SDIRFTNSNS
LLEYHYGLCSA--FANEVTLKLNIWDVKYGMKESVESLLENWNNFVEEKRLKTQLETATH
ICEDL---KNKNISNPDIAGDPQEISKLFKTVESKISMCKDYISSINTTLQKVLSSWSSY
TENLYLLKTWLEEKQNEYPIE-----VPAEVLANWNSVHGSLNEAGNYLIEVSKEQVGSN
IAKELKKLNRRWAKFMKKTRF---------------------------------------
-----------------------LGE----------------------------------
--------DNTDTAEKARELPGSM---EKIEELLGS------VDSWAAETECLLGEIGHK
TPVE--PQMEEHLQSLAARGISCQEQVMAVEEILQSLMKNASSQVS---QQHCHTTGLPA
RIKE-ARDRIEALMADMNNILPKSEKK-PSQKEALLNFEDSQKDIEVSISKAVQLVSQKL
SPEVHISRYEEAFNALDNKVLDNFLKAVEQLKNISSDQEKLVVEEKSEDIRKRWEAVHNE
MISCVQ-LLLEREKKKFNTTFKKINKQLGKEKKLLNMNKTKGLIREHE--AFFSHEGSLK
ELSKSLEDLKILGKL-----AEKTVPDLQTFAADSEEKLEKLQQNVADTYTAL-----LS
HAGRRQ--PSKKEGSIVASENGEKPSSTQQMDILSVQETLRP---S-----EDMVLETDM
KHHNGESCEKMFEEYSDLPTPALLESYNTQRRNLEELLQVSRDKVASGFTDEI-KGTSCL
QNKLLELQ-MVENDISSGWTQLGNISSTLENLVDEVEQA-AISETRSKLEGEWKELQDII
STRTNSLRTALEIVLPIENESILLCELD-QQLNKKGIQQFNLMNSDLAYRELKE------
-LQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------RSILNQIEVCKQL-EHLDSSARDEFN
PIDLQAASKIMFYYQNQLEEMSHKMQIRETVLKDLEAFMASLRKIKSSVEHLTDPLGQPE
IQ----GKTWREAAQELSHMAK-EAQCLDERLKTVDICLEDAEFGRNTSCEKLVQTLSEE
LNVSGDHSSEQMLTEGNDLYKI-------FSTRNEELLKNIQDLHDRINKIGLKDPTAPA
IQQRVKSLMELEKELDCSAVEMKSMREITNKLLQMKEEKAEESNEQCRVTERSWEDTKLL
LAECQEQCARALELLKQYQSCKSSLTSIIQKQEIVLSQQNSYMGKDNLNRLITKIEEAKE
EFNDHAEDVDKINQICKNLQFQLNKMRSFEEPPFENEANIIVDRWLDINEKTENYCDNLG
RAQALWDKLLGLSGTIDAWANAELKNAEGRCLTNEDLTQLKACLCVQEQKLQKFDNTVAE
IEELLNSNEPPLELQVIRSSIVQKMELIKDLLTTKRRTSELSVNTAELKGDLDLAKTQIG
MTESLLKALSPSDTLEIFTKLEEIHQKILQQKHHVTLLQEETDC--PDVDELNKQLKCVT
DLFNKKKHVFQDHCIGVLNRQCKNFNDWFSSTQLSLKDCFDPSETKQMLEERLQRLKHFL
TSEGKDGDIQEVKTLLNKAKHYLPKASINQLSSRVRDQEAELQRLISKCQKREKELGTSL
QQLKSLQESSTVLEKWLTTQEKKLQEIKKDETKLENLYKTLLMQREPFDSLAQLANSLRE
TGL-T-E----DEIISETSDLVSRYQTLMTNVNEMAGNTQGLSVD-EHFKELAQDMSSWI
KKLEKAINNLSSQESELPPEERINQIKEIIALKDAGDAKIQNIVPLGEMLIKNDKIKKPE
V--QQTVSDLQNQWERICQLAAAYR---------RELYEQSKEGLRLALIGLKKQQQEMG
FALQPGLLEKQAQLSSYTKLLQKAEDLTSQFNELESQ-DHLQSFAENPCFTEESWLELKH
QHENLLSQLQAAVETLERHVQEHQQFQDMVTALSTELKTVSKKLADCVSPAVEQPSTEQK
Q-LKSQEQQAPLCQLEDMLKKILGLAETVKQNTSSLGQKY-IEDEIETLQS-EHRSLEEK
LENVKQKKENIFSEAL-ELKDDLMDGIQMENKTDRMLKREMQITSDTPIAAEEGTTTAEL
RECLEMHNGQVVIGSVSEKEKQNGLLLEESSVLSDSPLQSIHQGKDRYSQTAQQEEADK-
-------------------------------------------------ESPGMDTCDGV
QENLLDRAELERRQDDVGAGSDEIRRETSPVKQKEKPADVKNQSYREDEDQVQQSVCLKS
QILKPVTAETDGLESDPSVSTHEKEGAAGVDEKELLPGVQANTDYFEEEQKVNELKNEVA
ELDIVLISEQLKELENLQTELETWKAKSLRLSQETLPDATGSNGAELRTPEPVVPCWDRL
LQELDAVKAVKQQQCCLVNEYQKNLSAAQSSMKNLATEKDNIKM-GPMNNTVLLEKIKAC
VQSLHKERDVLNQLKTQQELLSQHLTCMDKVLTASQMRQLEQWWQHMEQAVQKKHDQVLA
EINEFNTLMDKAQDIQRLI-Q---E-QY-LQTESCSSAGEKAKCPII-WTAELQNIKHGL
SLLKRKIELQMKRIWSDEEKVALESCIQDLQSKLEALSEQHTPQDDVRITGPAVKKQDIM
KKLKENISWVQDSLSSLDQKAALFPCDVKSQIRSCELMRNEVLDREPVIETLGNELQHII
PNLKPEEVSDMTSLLQALQNSYEALVLKSVERLQHLELQLEERQRLIAEVEKVHCQLRNA
ETLGRPDVNQAS-TCSELISQQDILKEILKDIQEIEGLISSHCEGSQITAGELSLSEQLF
LIDQLRSLKNRARKTQRQIQSKCHEVGKKIAAYREFAEGIKSLQQDLGD--LQCSELK-M
EE-ELTEATEEVKNKCRALKEKVVSFQSNLSQIMKFKEIFECIGLNWDSFQLDELHELQT
QFFRIKNKIKGKMTHFDNVIRECDKFYALLNEIWTMMSAVRKEAKILNDRSNSSP-AESL
ISAQILLQTIQQILNLIQEVANQISKNEAFHTLFKESKRQEIKSLEKDVEELSQFL-QN-
-LVSSLQCENKEDIQNVAEHLSHAIKHVQLELQQPLLVDMK--MMQYEKMRWESIQNMMS
AEFSAIKCIMEKERESQGEKS--LAADVETKLRKLADHEIQLKTDIAARVSALEEACKAG
ELYTKAVERAAKFLEDCEAQVCSAAVELSSSEDTYQTPPWK-QEEFDSAKADIEQLYSKL
KNLLKPEDKICLENTLRELVNKSLALKEKIQRNEADKQ--RYL------EKYKSYSKCKD
KVRDDLHNLGKMLGQSLSQIPMSYKEALENLQECKILVSNIDSAEDDLVKLRQVSGELMR
LCKGSDRAL-GRIVTALWENWLGLLEAAKELEINCEELKQEWKFINEELEREAIILDKLQ
EEQPESLKEKEKATREELVELLDSVYAFEENISRQQLLLLLLLHRIRNILNTSENVEAET
A-LPALCEIKTMQDRCKKLYEKTQDHKNLVQSEIQERNKIIEEINAVKNALQNALSVLSQ
DAV----GKAAQLKEVQSVIAKESQNLKDIMEKLRIRYSEMYTIVPAETEAQLEDCKKTL
QDLEDKVSFENLQSSPQYVLKGKAETINNGLQAIEKMLEQKSENVAKAKEVQKQIWDMLD
LWHYKLNELDAEVHDIVEQDSCHAQELMDILMTPLQRYQEVSQLAEHRTAILNKAANKME
EYDELLKDMKVWIENTNSLLKADAQNDSAKRLHEYTDGLQMA-LEDSEQKQNLLHSVYLE
LEELTPVFETGSIMQ-QLNEAEEEVAMLQQEIADILPQIQHVTDELDAIESHVKMFEKDV
MKMKTILS-SEDLLELSPKDQLKHGQ----------------------------------
-VILDHIGPMQKTIVHIQSYEEVLQLPGAKKQPVSVFLRARQLLRELKKIEKITKEQNEL
LEE-AVKETEECEQEIEKLKQFLKNHLAEKSHEYQPQTQKTSCPE--G-EMEAIKEEIIK
LCQRKEDILTGMKNSMSELHQRLQEEAPEPG--DEPTASVFA-QTDSI-----GTEVSDV
QLKKRGLISLLPCLDEESED-SFHS---KGNTTTEIDVSFWPSLKYKEKHK-EDSAT-SW
SSGTLSDGGTQDAAEIVQSCKKGDEESSLQTP-QRT---EGPGTGLESQTV-SGTPPPVP
NTTQGSRGKEG-DPEEAV--DGGRPEPETILQACKAQVAELEQWLDKTKVSLGSDPQTPK
MQQMVELQLGDFQVMLSEIEQKVLSLLEDG-----GNSAGHQQEAEDLSLKLKEMKCNLE
KVQMMLQDKYSEEQ--IPSRERID--P--ESLKILHSNGSSMPHLGLAEQPFLQQ-NGFQ
HPQ--DLKVKAAEQKSFIDFIESC-VEKM---QPQLEDSV-TQKSEP---------SN-G
ESDAKSKQADPTLAPKDQ-TGNKWQY-----L-QQELSSKMKSPLC-QLVEPQITTKLNM
LPRGTFPNAGASTVEELKTYTVQLGDLSQEANVVHAQENVAEEVSSNLDKKLFELLLAIS
RCLDNMEEMLNTSVLSTEEAAVQQVLY----ETLSVELQKLHADLSDKKDDLLKSITCAG
GSTDVFCECFNNLQAWLEQTQAATASRSNSVKAGLDHNTSYQNETRLLYDQLTEKKATLQ
QCLNAIRGHNVSEQLQKTDACALELQNFESQVAKLRGYGERFQLPVTLIQEAYKLEDVLD
DMWGILKAKYVELYSPSISESQYEDLLRGFAELVAIGREKIAQDAKQLTKSRAALQSHLE
NHKDFFHNLMTHMAFMQAFSKKVTPSVLQKREKFWSGLVNDVRLLEQKASQYGIHLESLL
KEWTEFDDECLAFNKELEALTSTLPSVNLVEETEERLMERIALLQQIKSTVDEKHARLYQ
MVKEGKKLLTAVSCPEITNQIGKLEEQWLSLTKKVGNELHRLQTLLKLLV------SYNR
DSEELRKWLDSAEQRMKFWKEQSLNVSQDLPTIRDNIDSLFTFSKEVDDKSSLKSSVVST
ANQLFHVKQADTAGLRSSLAKFEQKWGELITQLPAIQEKLHQLQMEKLSSREAIAELMTW
LDHVEQQQGHEEPINAQSSVAQVRSLLQKYKEYMMEMNFKQWMVDFVNQSLLQMSTCDVE
SKRYERTEFAECLGEVNLRWHRLQASLNRKIQDLEHLLEDTTENENKAQTLCNWLEAQSD
RMRSLQTPASLISAQNTLDDCKDLENQLAVKSKMLDELKQSVS-LNG-STEQTPEALSLR
IADLCEMKDSVASQVAQLKTSMQSILEQWRVYDDVYAEVSLLMTRYLYCLDQCKPSV--L
SLEALKNQVKTLQSLQDELENSEESWAKLQAAANNLKKNCSPSFAEIIDQKCTEAH--TR
WSSVNE---DIADQLRTAQATLQLWEPYDSLCTEAAAKLQQHEEQCTQLLDARMPEDNMI
ETLKQRIQDVK-NLQHGLQNIVGCRSQISELADQIKQ-QAGTAAQAVLLEKLQPLQRASY
LEKMLQRKLDELEFNLSQLEDFKNCLETLEGHV-KNCTDAFDSLHLEGE--TDNSELLMN
HTLELAALSPSIESLNEASIKLPLSDFTLKKMQSLTRQWSQKTATAL-EHCSVLEGTQTD
-EKKFLQKCENWMKFLEKMKEALKTNVPGQFEELQEQQRIYEMLQTEISINQQTFNSIIA
KVLLFLESGEAEKRTEFISKLTLLKEQWQNVIWLVQQRKKDIDGLVSQWQLFR-GSLR-S
LSRFLADTNSFLTAVKSQDCYSLYHLRNLIHDFKSKAVILQRWQGMYSSVIDVGEKLRN-
-DSDPETSAVLQEELSQLQQCWGDTQVQLEKMKMQLSSIL-QSWDSCEKQTKELESRLRE
LKDEVKDPLPVEHEELYKSKEHIKELEQSLADWAHNMKELRAMKAELAHCILTEDMMVLQ
EQVEHLHRQWEELCLRVSLRKQEIEDRLNAWIVFNEKNKELCSWLVQMESKVLQTADVSI
EDMIDKLQ-----------------------------------------------KDCME
EINLFSENK-LHLKQMGDQLIKASNKSRVAEIDDKLNKINDRWQHLFDVIGAR-------
---------------------------------------VKKLKETFAFIQLLDKNMSNL
RTWLARIESELSKPVVYDICDDQEIQKRLAEQQ-DLQRDIEQHTAGVESVFNICDVLLHD
SDACANETECDSIQQTSRSLDRRWRNICAMSMERRMKIE ETWR LWQRFLDDYSRFEDWLK
SAERTAAGPNSSEVLYTHAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQMVHEGNQRWDNLQKRVAAILRRLKHFTNRRDEFEATRENILVWLTEMDLQLTNVEH
FSKSNFDDKMRQLN-GFQQEITLHTNKIDQLIVFGEQLIQKSEPLDAILIEDELEELHRY
CQEVFGRVARFHQRLTSRHPGLDDEKETSENETDPED--SREIQNDPWHKKAISEG----
PSSPQSLC----HLMPPTH----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDE----EEATYYSAL-----------------------SGKAVSEAHP------
------------WHSPESPVCRKHRYSQAEIVGDVLS-GAETSTPYKPGYVTQLSSASS-
SSVNKENITSANMSDEEPQ-DD-QELVTITA-AEKQSGIIDRWELIQAQDLRNKLRIKQH
LQQWQQVNSDLSDVSAWLDKTEE-ELEELQKAKPPTSMQAMEQRVKKLKDTLKAFDNYKA
VVLSVNLSSKEFQKADSTEFKE--LQNRLRKVNLRWEKATHALDNWRKGLRQALLHCQDF
HDQSQKLILWLASAEGRRNEAQ-I-TDPNADPHTILESQKELMQLEEELLEQQLKVNCLQ
ELSAYLLLKSDGEDYIEADEKVHVIGKKLKQLIEQVSHDLKTVQGSLDSRV-FLPV----
--PD--DLD-SEV-YHPVAVKSSPPV-KKIA---IRRTSDG-RKNS------NTRAESNA
QPTHVVPRSPSFFYRVLRAALPLQLFFLLLLLLACMIPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVPPTEDE-QV-SLGIDDRHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHIPPSVVSDLFADIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVTDIIDGNPSIILGLIWTIILH FHIE----ELARTLSCN
YNQ-----PSLDSVSVA-D--SSPTSSPPAKKCSR--AQERWQMSA KKALLLWAQEQCAS
-YES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKHRSNKDNLKEAFGIAEREFKI
PKLLEPEDVDVANPDEKSIMTYVAQFLRYSKDAAETGDKTQG-KMKDAV--------AWL
TLPEKKLPKVLKDSENETYSKKYEI----LLSFLESFNEEKKPFLDILPIKRNPAELSED
QLQLREAWDGLNYQINVWKTELNHALPSPLHQIEAWLQEIEGLIDEDLPASQDYCEAMAL
IQEKMTLIKNLMDKFDCNSNTLLTFENRDEEHLPLVPPKKLEEMK-GRI-NNISGKKLIP
RLEFHYYKCSVLGLLDELKLKLDVWNIKYGNKASVELLLEDWHKFIEEKEFLAQLESSFQ
KCEEI---HKN------LAGQHQDISEQYTAVEHNICMYRKNIYNVKSTLQKVLTCWATY
VENLLLLKACFEETKKEQMKE-----VPFETLSQWNREHTTLNEVGNFLIQVSNDEVGSS
ISKELRRLNKRWRKFITKTQLDMNLPL-I-KKQDQPNFDNYEN----------T-QLSKE
EKPTVDFSTDMSIELPENHNE--NIK----------------------------------
--------AGEEREKEN-EFTGQLKVAEEIEKLIGQ------MEIWEAETKSLLDILRRQ
EGVD--ASVEESLQHLIAKGSMYEELVSRTEDTLQMDVQNISSQES---LQHVLTVGLQT
KIQE-AKEKVQINMVKLIAVLKNSTDA-SPNLDVKLRVEESQKELESYMTRAEQLLGQKE
SRSGLISKYKEALIILNSKSLVKYLKAVEELKNNVTEDVKLSLEEKSRSARAKWESLHQE
MSLYIQQLKIDIEKEKLNDNISKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEASLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIHMTL-----QP
TMG-GT--SKNKETTNPSENGGRDSHSEVPSVKSENQPSTEK---A-MDSIKNFSLESKL
KPQPEENFMKKYEKDHNAALSSLQERHDMHRENLELYLEKNKFRIISDFSSDKERSSACL
QDKLTDLR-VLKNEIDACWKEFEITSLKLEELDSDVKKP-FISNMRDKLKEKEREFQMTL
NTRMESLETALKIVLPVEKESLLLCGSD-LLLHELVIQEFHLIDIDGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAKQVEICNNV-EQSGDFALKDLY
PVDVHATQNITLKHKTQLEEANHKVQRSKDALKALEEFLASLRTAELSFEL-----SASD
TQVVPEDTLTVENKKGEINLMKDQARHLDERLKMLGISFKDAERGDD-TCDKLLDALFRK
LFETRGYGVQEELTEENKLLET-------CILKNNELLRNIQDVYNQISKISLKDPTVPA
VKQRKKSLMKLDKDLDEYEEEKKCLQEMVNSLPQFKDGREKSLNQQFQNTVHLWESTKTS
VTECLDQCERVLELLKQYQNFKSILTALIQKEESIISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICRNLQFHLNKMRIFEEPPFEKEANIIVDRWLDINEKTEDYCENLG
RALALWDKLFNLKNVIDEWTEKVLQKMELHQVAEEEREKLKEELQVHEQKSSEFSKRVAK
IQFLLQSSEMPLELQVMESSILNKLENVKMHLIGESNCSALSGSTAELREDLDQAKTQMG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMMLLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIKMNLKECFESSETKKNVEQKLQKLSDFL
TLEGRGSKIQQVGTVLNHVKKHLPKAHVKELNSWIINQEIELEKMDSICQTQAKELNDHL
QQLLRLQDDHRNLSKWLTSQEEKWIEMEKSGEKTELFCEAVAGKREQFESMAQLNSSLKE
YGL-TEE----EEIIMESTHLIDRYQTFLRQLCEIDEEDKLPPTEDQSFNDLAHDVIHWI
AEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTIMSQAE------SSKAPL
A--PKTLTDIKNQWDNTLHLANTYLSHQEKLRLEGEKYLQSKEDLRLMLTELKK-QQEAG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGSYLLECTKNPNFSEKPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLNTALDDISKEFASFSDKPVDQIAVEEK
V-QKLQELENRLRLQDGILKKILALAKSIKQNTSSGGQKI-IKDDIKSLKC-KQKDLENR
LECAKQESENYLNSIL-KSERSTEQ----KEKF-PLPGREKEVTSDVQEPTQDSAVPEKF
EEDREINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEVVLSKQLSLNVQESMKNTEDEHKVNELQNQPL
ELDVMLRNEQLKEIEELYALLEAKKIATEPLEQTECLNKAEASALVLHSTRYSVHHLDSL
LQALITLKKKKESQYELLNNFQEHLAAVESSVKALLTEKESLKV-GPLDSATYLAKIKQF
LASIEKEKDPLSRMKTEWENVSNCLTDMDKKLLESQIKQLVNSWEQVEQLAQKKYSQQVV
EHDEFMLLMNQIQDLEISV-Q---QQRQSLQLGLNSMEEQDGGLNTIALATELQNMKHQF
SVLKGKAEFQMKRIWGEKEKNALEDAMNNLQKQLEAL-EPLNIKVE-----NQIKKCEVR
NKMKEIIQWVKNLLGEVTPTISLFPDDILSQIRKCKVKHDGILDKQQAVESLVEEVKKNI
PNLTADESNDLNHLLQDLQNQYQMLILKSTERSQQLEFKLEERNRFIAVIEKLQLSLQEN
EAQIIPKMKTAS-TEPELEQEHVTLTSSQEALQEAESVISARLQEQADVCKDLCVFERLF
LGDQLKNLKTRANRTQRVIQNKCNEVERKIHFYREYHEKASVLQKEVDH--IQHSELP-L
NQ----EIHEDVKEELYSLKDRITGVQSRILQVLKLKEVFDSLGLNWDSSQLD---QLQA
QVFEKEKELEEKIKQLDTLVAERGKYQASLSKLRAMDLQIKTRAEALLEMPHASP-ASSL
LSAQILQRRIEKAMCLCQEMIKNLNQSKTFDDSFKEKEILQIKLCVEENDKLHKIL-QDK
VLESQPKEMGEKNFQDKLESSIHVLNQIKSQLEQPLLINLDIEHIQNEKENCEAFQEQVQ
VEMDSLKAMTLIEKQRE-ENSL-ETCEVETKLHDIEDLHMQLNTSIDLRTDVLNDAYESM
TRYNEAITRAMGIFTACEAIVASHKVDLDNPEEPLEMSYWK-QEELQSTMADIQDLTEKL
GTISSPEAKQQLQYTLQELVSKDSAMREAAKVKKSEIE--RCL------ENYKCYRKIKE
KVCTNLSQMETVLGQSMFPLPVSYKEALERLEQSKALRSNLLSTKEEFMELRQVLRHLRP
MCTDSDDRCLLRTTLALWDKWLSLLEAAKEWELWCEELKQEWKFVSEEIEREAIILDNLQ
EDLPEISKTKEAATTEELCDLQDCLCRYQENVEKQQLLLTLLFQRMRSIQNAPKSLEAVE
T-SPTFQEITSMQKRCNKLFQKAQENKELMENEIQERHSFTKEMISLKNLFQQTAASFQN
MELQDHPERADQFEELQSIFKKGKLTFENIMEKLRMKYSEMYTLVPAEIESQVEECRKAL
EDIDEKISNEVLKSSPSYTMSRKIDEINNGLHDVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQNPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQVNKATVKME
EYHDLLKSTEAWIENTNRLLANPADYDSSKALSQHASTLQMA-LEDSEQKHNILHSIFTD
LEDLSIIFETDDLAQ-SVQELNHQVAALQQKIMESLPQIQRVADDVVAIETEIKSIEKKV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKAIAELVSYQVELRWAQMGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKI-VIKQTDECNEEIENLKQILNNYSTEFSHERISPDQTTNLPQVQG-NIKGMEKQILS
LTQKREDLLVDLKAAILNLHQHLQQDQQESE--QEMPSTGAS-EEEGVAER-DASEWKL-
--NKISSMSFLPALKEEVEESSLKSENGDKKAKPSSGS----LLWKHDGDM-EEDRA-SS
SSGTIIQE----AVEKISTCDNPMAQILAPD-------------SLSPNQTEEGATPTVK
AAALGFSNEQG-AFETTV--EKARSKPAEILHVCKTKVAELELWLRQANVAFEPETLNAD
MQQLVEQQLVGCQAMLTDIEHKVASLLESCKDLGPGDSGATQQEAEALSLKLKTVKCNLE
KVQIMLQEKYSEDQ--HSTTLKKP--S--EHPNDLQADNLSEFESIVIERPQFGKQKDFQ
QQQ--VLELKPMEQKDFIKFIDFN-AKKMWPPYCQPDENV-TQKSTE----------SMR
ASSLENDAPGSVLSTQDE-SGDKWQY-----L-HHELSSKIGLPPP-KQVQPQVATNMSV
LPNVSMYNFRYPTTEELKTYTTQLEDLRQDANNLQTQENMTEDTYINLNTKLFELFLTLS
QCLGSVEEMLQTPGLSREDVCAQQAHY----ETLALELKKLYLAMGDKKDDLVKAMTWPE
RNTSLFLECFNNLQVYLEHTQIAAASRSKSLKAGLDYNRSYQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIDEQLQKADAYTVELQNSESRVAKLRDEGERLHLPYALLQEVYKLEDVLD
SMWGILRARSTELSSPCITERQENALLRGMVELVDIGKEKLAHDHLQQAKSKAALQAQIQ
NHKLFFQKLVADMLLIQTYSNKMLPSLLQKKETFWAEQIKEIKSLEERSHQCGIKLQSLL
QKWEEFDENYTSLEKDLEILVSTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPELEGQITKLEEQWLALNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKELDDKSSLKTAVVST
GSQLLHLKEADTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAIMEMISW
MNNVEHQTSDEDSECSLSSASQVKSLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKIQHLEQLLESISENENKIQILNNWMEAQEE
RLKTLQKPGSVISVQKMLLDCQDIENQLAIKSKALDELRQSYLTSES-GTMPLLEDTASR
IDGLFQKRSSVINQVNELKTSMQSVLQEWKVYDKLYEEVTMMTIRFWYCMDHSKPVV--L
SLEALRCQVQNLQSLQDEAESSEGSWEKLQEVIGKLKDHC-PSVAEIIEEKCQDTH--AR
WTQVNQ---DIAEQLQKAQSLLQLWKAYNSAHTEAAARLEQQEAKYQQLENINMSGNNLA
EILTSALQDVK-ELQQDVQKTKEAFLQNSTLLDRLTQ-LTESSTHVPLSTQLHSLQRASY
LEKMLLVKANEFEFVLSQFKDFGDQLESLKGLI-MREEENLDKLYHQEK--EENPDLFLK
HVLALTAQSPDVEHLNAVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWVQLLEKIEETLKVNIGNSLPALLEQQKTYGMLEAEVSINQTIADSYVT
QCLQLLDTTEIEKRPEFISKFTKLKDQWQSAAQGIQQRKSDIDGLVGQWQYFT-TSVD-N
LLRFLTNTCHLLSAVKSQDCYGLHQTRRLIRELKSKEIHFQRQQTTFELTLEAGEKLLN-
-TANLETQDLIEKKISQIRDDWENTKLQVGEMIQQLQSNV-ETWGQCEKKIKELKSRLQV
IKAQSRDPLPELHEDLHREKELIKELEKSLGNWTQNLKELHTMKTHLTQHILVEDVLVLE
EQTEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKTRAAEIEDKLSKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKHMVHEGNQRWDNLQKRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHTPGLEEEKEASENETDMED--PREIQADSWRKRRESEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSAL-----------------------SGKSISEDHS------
------------WHVPDSPSCPKHHYKQMGGDRNVQTIPSDSSTPYKPAYVKLLLSPGT-
DGGKEG---SRVLNGSSRQ-ED-KGLAALTR-QQ--SGAFDRWELIQAQELHNQLRIKQN
L---QQLNSEISDITTWLKETEA-ELETLKAAEPPSDIWEMQLRVKRLKEILKAFDTYKA
LVVSVNTSSQEFLQTESAESNE--LQSRVGQLGLRWDAAQGAVESWREGLRQSLMQCQDF
HQLSQDLLLWLASAESRRQKAH-V-TDPEADPQVLLECQGELMQLEKELVERQPPVNTLR
EISDSLLSKGHGEDYIEAEEKVHVIEKKLNQLLEQVSQDLMSLQGSQNLDP-SLPS----
--LD--EVD-SGD-QPPGTSVPAPQAQQCGA----ERMTKDQNKMD-------SRVPGPA
GPG-SSRPQRSFVSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
STHLGGSQGGLRKMTRLPAPVAASVSQTLQAASCNGYQLKRICLDVTKLMKVMGRKGYFA
V

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----------------------MQELEKSLANWTQNLKELHTMKADLTAHILAEDALALQ
EQTEHLHRQWEDLCLRVAARKQEIEDRLNSWAVFNEKHKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASSTARATEIDDKLHKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETFAF IQQLDRNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

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----------------------MQELEKSLANWTQNLKELHTMKADLAVHVLAEDAMALQ
EQIEHLHRQWEDLCLRVAARKQEIEDRLHSWIEFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSDNK-LQLQRMGDQLIKASSTARAAEVSDKLHKISDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDGNMSNL
RTWLARIESELSKPVVYEVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRN----------------------------------
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-

-------MASQQSSASTEE-QT-SSEIDDLHL-----TLQ---------VQREFTQKKTF
TSWINSILAKHTPPYVVSDLYTDIQQGHLLLDLLEVLSGQHLPREKGFNTFQCRSNIENA
LTFLKSRS------LKLINIHVADIIEGKPSIVLGLIWTIIFH FHIE----ELARTLACT
YNQ-----PSPDCSSAVD---SSPKASRSAKKSAK--IKERWKMSAT KALLLWAKEQCSL
-HGSVISVTDFKSSWRSGLAFLAIIQTLRPGLVDLEKAKVRSNKENLKEAFRIAELELNI
PRLLEPEDVDIVNPDEKSIMTYVAQFLQYSKNLPESEEDMQE-KVREAM--------GWL
AAQEKKLAKLLVETENETYYQKYKE----MMSFMETFNQEKIPFLPVLSSKRGEAELSGD
QQQMREEWDKVISQINEWKAKLDQMLPSPLGSIEAWLQEVERLQAEDLPDLQDPFKAMSV
FREIIVIFKGLMNCFDSHLDTLQSFKNEDEKKMPLVLPEKLEEMKICRF-SNIRSTNPST
FLEYHYGLCSA--IANEVKLKLNIWDMKYGAKESVESLLENWNNFMEEKDLETQLDTATH
ICEDL---K--NISGPDLAGDPQEISKLLKTVESKISSCREYISNVNTTLQKVLSSWSNY
TENIHLLKTWLEENRNEDPKE-----ISAEILAKRNSIHGSLNEAGNHLIEVSKEQVGSN
IAKELKKLNRRWAKFIKRTHFVSYKLL-L-LCAMLSK-----SS---FLDYQLA-NQ-RL
INLPVN---SRL-----PVLELELGE----------------------------------
--------ESTNAAEKPTELPGSL---EKIEELLGG------VDSWAAEMGHLLSKISQE
EPVE--PEMEEHLQSLAARGSSCQDQVVAAEEMLQSLMQNVSSQGF---QQHSHTTGLEA
RIKE-ARDKVEAVMGDLNNILSKSEKR-PSEKEALLNFEESQKELEASISKAVQLVSQKL
SPEDCISRYEEAFNALDNKVLDQFLKAAEQLKSISSDHEKLVVED---DVRRRWEAVRQE
IVSYVQ-LIVEREKKKFNATLKKINKQLGKEKKLLNMDKTKGLIKEHE--SFFSQEGSMK
ELNKTLEDLKTLLRL-LRSFNQEDNGRIQALTADCEKRLEKVQQMVADTYTAL-----LA
RVGKGQ--SAQKGDKTLGLW--------SEIKTPLCLQTSRP---A-----ADTVLEPDV
KHHNGESSADKFEEDSDSSIPTLLESFNTQRSNLEELLRLSRDKVASGFTDEI-KGTSCL
LTKLLELEGIIHNEISSSLRQLENISSTLENLVTEVQQA-ALSEARKKLQGEWKELQDII
SARANSLRTVVEIVRPVENQCTMLCELLNQWLKKKYIHQFNLKDSDLAYSELEE------
-VQNFMGFPLRRLRLLTNFPNLLKTVTASKLPCVTSAAVPEQSS--GWVWKLSVGAVIVH
LLSICDAQALAHWAGLALWAEHTDSYTTESLHLSALGSPMKIFAQLSAQLGFHNLTCCSL
RAITREPAGCTSCENLLLSVPELLSSLSPPCLIVGRSLELSVVL-IKFP-LCGIPFDLII
LFFFLPSTAIQKRFSILITLFS-ILFYSYYKALERSILEQTEECRQLKQDLDSSPRHECN
PIDLQAASKIMIYCQKQLEEMGHKLEIRDTVLKDVEAFMASLRKIQNSIK---CPPDQPE
IQ----GKALREAAEEVSHLAE-EAKCLDERLKTVNICLEDAECGRKSCCKNLVLTLDKE
LNAIYDPSSEQVLTEEKDLYKT-------FSRKNSELLKNIQDLRDRINKIGLKDPTIPA
IQKRIKSLTELEKELDRAAAEMKPMQEIANKLPQIDEEKAEEANEQCRVTERLWEDTKFL
LAECQEQCARVLELLKQYQSCKTSLTSIIQKQEVVLSQQTSYMGKENLNRLIAKIEEAKE
EFNDHSEDVDKINQICKNLQFQLNKMRSFEEPPFENEANVIVDRWLDINEKTENYCDNLG
RAQALWDKLLSLSGTIDAWANAELTNAEGRCLTEEDLTQLKACLRVQEQKLQKFDNTVAE
IEELLNSNEPPLELQVIRSSIVQKMELIKELLSAKRGTSELTVNTAELKVKKSDER----
------------------------------------------------------------
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-----------------------------SVKHSSDLYGNYRRKKKPFDSLAQLSNSLRE
AGL-T-E----YETLSEASNLLSRYHALITRVSEMAGSTDRLPVEGKED-----------
------------------------------------------------------------
--------------------------------------------LKQALMELEK-QQQEI
FALQPGLEERQAQLANYADLLQKTEALTSQFSKLKSQKEHLQGHTVDPCFTEAEWSELKH
QHENLLSQLQTIMQTLESPVQEHQQVQDVVTDLSTELQAVSEKLAECDGPAMEQPPAEQN
Q-LKSEEQQGPLSRCEDTVKQSLVLAETVKQNTSSPE-QF-IKDETETLQS-EHKSLEER
LENVKQKKEN--------------------------------------------------
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MFSGVLGLSEVPSVVGLDG-KS-FWLINFFFFFILYRSLY---------TEQEDTQKKTF
TCWINSQLAKHTPPSVVTDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIENA
LTFLKNQS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----ELARTLPDN
YSQ-----PSVDSVSAV-D--SSPTSSPPAKKCSK--VQERWRM SAKKALLQWAQEQCAS
-YES-VTVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKHRSNRDNLKEAFRIAERELKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLQYSKKAPGSGDEAQG-KVKDAM--------VWL
ALQEKKVQEMLTDSENETYCKTYES----LLSFLDSFNKEKERFLDVLTIKRNVDDLNKD
QLQLREAWDGLNYQINVWQTGLNRVLPSPLYQIETWLQEVEKLMDEDLSVSQDYNEAMAL
TQEKITLFQSLMDKFDFHLNTLLAFENRDENHLPLVPPEKLEEMK-RRI-NNISGEKVIP
RLEFHYYECSVLGLLEEVKSKLLVWNIKYGNKESVELLLEDWHKFIEEKEFLAQLETSFQ
KCEEI---HNN------LAGEYPNISKQYTMVKYHFSMYRENILNVKSTLQKVLACWATY
VENLHLLKACFEETKKEQMKE-----VPFETLSQWNLQHTTLNEAGNFLFQVSNDEVGLS
ISKELRRLNKRWRKFITKPQPEVNLPL-M-KLQDEPFLDNSGN----------I-QPSKE
ENLTVGFSTNTSSELPENHNQ--NIM----------------------------------
--------AGEDHEKENEDFSGPLKVAEEVEKLTGQ------VETWEAETTSVLDLLRQQ
DDVE--TSVEESLQHLIAKGSMYEELVSRIEDTLQMDVPHVSSQES---LQHVLTAGLQA
KIQE-AKEKVQISMVKLVAVLKNSTDV-SRDLDVRLKVEETQKELESYITRAEQLLGQKE
SQRGLISKYKEALIIFNTKSQAKYLKAVEELKNNVTDDVKLSLEEKSRDICAKWESVHHE
MSLYIQQLKIDIEKGKLSDSIAKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIHMTL-----QP
TLG-GT--SKNKGNTDASENGGGNTLSEVPSAKSDNQPSAEK---A-MELVQNFNLESKL
KPQQEESIMEKYEKGHSTSIDSLLERYDTHKDTLELHLQNSIARITSDFSSDKERSSVCL
QDKLTDLQ-VLKNETDACWKEFEITSLKLEELESDIKKP-FIVKARDKLKEKERELQMTL
KSRMESLETVLQMVLPVEKESLLLCNTD-LLLCKMAIQEFHLTDADDIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIVKQIETCKNL-GQSGNFALKELH
PLDLHVAQNIILKHRTQLEEMSHRVQKNEDALKALEDFLASLRAAGLSSELL-TDHSASD
SHGVPANTLTVEDKKREIHRMRDKARHLDEHLKMLGISIKDTEQGENTSCEKLLDVLSEN
LSETHCSGGQEEVTEEDKLLGA-------CVFKNDELLKNIQDVHNQISKIGLKDPTVPA
IKQRRKSLIRLDKDLDEYEEEKKHLQEMVNSLPPFKDGRDKALSQRCRDTAVLWENAKTL
VTECLDQCERVLELLKQYQNFKSVLTTLIQKEENVISLQASYMGKENLKKRIAEIEVVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFYLKNEIDEWTEKVLRKLELHQLTEEETEKLKEELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIEHVKMRLTGGSNCGAISGSTAELREDLDQAKTQIG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHNMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGSIKMSLKECFEPSETKKCVEQKLQKLSDFL
TLEGRGSEIQQVGTVLNHVKKHLPKAPVKKLNSWIVSQKVELEKMESICQARAKELDECL
QQLLRLQNDHRNLSKWLTNQEEIWKEMEGTREKTELFCQALARKREQFESMAQLNNSVKQ
YGI-TEE----EEIVMESTHLVDRYQTLLRQICETDKEDKLPPDEDQSFNDLAHDVIHWI
TGIKESLMVLNSSEGKMPLEERIHKIKEIILLKPEGDAKIQAIMSQAE------SSKAPV
V--TKTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQPGLQEKKAQLKIYKKFLQKAQDLTFLLEELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHDSYQLCVTDLNTALDCIAKEFVCFSDRPVDERAVEEK
L-QKLQDLENSLHLQDGTLEKILTLAKSVKQNTSSAGQKI-IKDDIKSLKC-KQNDLENR
LESAKQEMENCLNSIL-KSKCATEK----KAKF-PLPAREEQVTSD------DSAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSALEMILSRQLSLDVQESMKNTEDEQKVNELQNQPL
ELDVMLRNEQLKKIEELCTLLEGKKAAIEPLEQSEYLNKTETSALVLHDESYSVQHLDNL
LQALITLKKKKESQYCLLKDFQGHLMAAESSMKALLTEKESLKV-GLLDSATYMDKIKKF
LASIEKEKDSLSKMKIEWENLSNCLTDMDKKLLESQIKLLEHGWEQVEQLVQKKYSQQSV
GHDEFMFLMSKLQDLETSL-Q---QQQQHLQLRLNSPEAQEGNLSMVALATELHTIKHRF
SMLKGRAELQMKRIWGEKERKILEDAINNLQKQLEAL-EPLNMEVE-----NQIKKCETR
YKIKEAILWVKNLLGELTPPISLLPDDVLSQIRKCKVVHDGILDKQQVVESLVEEVKDNI
PNLTAYESNDLNNLLQDLQNQYQMLVLKSTQRSQQLELKLEERSKFVAIIGKVQLSLQGN
ETLIIPKTETAS-TEAELKQLYVALTTSQKELQEIKSVISTHLQEQTRLSKDLSVFERLF
LDDRLKNLKTRANRTQRFIQNKCNEVEHKINFYREFHEKISALQKEFDH--IQHNELL-L
NP----EVNPDVKEELYHLKNQITGIQSSILQVLKLKEVFDCLELKWDWTQLD---QIQT
QVLEKERELEEKIKQLNTFVAEYDKYQASLAKLKALDLQIKKRAEPVLTMPNTPP-ESSL
LNAQILNQRIGKAMNLYHEIIKKLRENKDFDDLFKEREIQQLKLHAEENNKLRQVLQQKV
ALQSQLKEMGEKDFKDKLENSLHVLNQIKSQLQQPLLINLQIEYIQNEKDNCEVFQEQVQ
AEMDSIKAVTVIEKQSE-ENSS-EASDVEAKLNDIEDLYMQLNASIDSRTNVLNDAYENM
TRYNEAVSRAMEIISNLEAIIASHRVDLDNPEESVEVPRQK-QEELKSTIAGIQDLTENL
GTISSLEAKRQLERTFQDLVSKHSALMEAAKEKEAEVE--RCL------DNYKCYRNINE
KICTNLSQMETILGQSMCPLPVSYKEALERLEQSKALVSNLISTKGELIKQRQVLRHLRA
MCTDSDSLYLLRSTSALWERWLNLLEAAKEWEMWCEELKQEWKFVHEEIEREVIILDNLQ
EELPEISKAKEAASTEELLGLLDCLHQYEENVEQQQLLLDLLLRRIKNIQNTPEGAGAVE
S-VPASQEIMSMQERCHKLFQKTQKNKELMQSEIQERHSFTKEITTLKNLVQQTTISFQN
MELQDCPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPEEIESQMEECRNAL
EDVDEKISNEVLKSSPSYTMSRKIDEINNGLRNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDKLMIPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWIENTSHLLADPSDYDSSKTLSHHASTLQMA-LEDSEQKHTLLHSVFTD
LEDLSAIFETDDLAQ-SIQELSHQVAALQQRITESLPQIQRMADVSCSFQPELRNLAF--
---------------LSPTCVPCLSK----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNRLLQDIKLLENVTQEQNEL
LKVSVIKQTNECNEEIEKLKQILNNYPAEFFHEHMSTDPAANLSQVQG-EIEDMEKQILS
LNQKKEDLLVDLKTAILNLHQHLQQKQQELE--QEVVSVGAS-EENAGAEK-DASEWKL-
--NRTGSVSFLPALKEEAEESSLKSESGDKKAEPSSGF--PSLLWKYDKDV-EEDRA-SS
SSGTIIQE----AAGKISTCDSSMAQVLEPDLLNTE---RGPEFSLSPNRTPEGATPPIK
AAATGLSDKQG-AF------EKVRPEPAQVLHVCKNQVAELELWLHQANVAFKPETLDAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--VKYDY--------------------AYLSGRDSGPQFSRQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-ANKTWPQYCQHDKDT-TQTSSA----------SSK
TSSPKNDAPDLILSTQGQ-SGDKWQY-----L-HHELSSKIRLPLS-QLVQPQVTTNMSV
LPSVTVYNFRYPTTEELKTYTTQLEDLRQEANNLQAQENMSEETYKNLDKKLFELFQTLV
QCLGSVEEMLQTPGLFRGDVGTQQVHY----ETLALELKKLYLAMSDKKNDLSKAMTQPG
KNASQFLDCFDNLQVYLEHTQARAASRSKALKAGLDYTRSYQNEIKRLYDQLVKNKTSLQ
QSLNEISGQTIDEQLQKMDAYTVELQNSESRVAKLREEGERLHLPYVLLQEVYKLEDVLD
STWGLLRARYTELSCPFITESQQDALLQGMVELVHIGKEKLAHDHLQQTKSKVALQAQIQ
NHKLFFQKLVADMLLIQTYSNKMLPSLMQKKETFGAEQVKEVKLLEEKSHQYGIKLQSLL
QKWEEFDENYASLEKDLEILMSTLPSVSLVEETEERLVERISYYQQIKRNMDEKHARLYQ
TLNEGKQLVASVNCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSRKAIMEMIDW
MNNVEHQTEDEDSEHSLSSASQVKNLLQKYKELRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGALNGKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTLQKPESVISVQKTLLDCQDIENQLAIKSKALDELRQNYLTLES-GTVPLLEDTASK
IDELFQKRNNVMNQVNELKTSMQSVLQEWKIYDKLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVQNLQTLQDEAESSEGSWKKLQEVIGKLKEYC-PSVAEIIQEKCQNTH--TR
WTQVNQ---DVADQLQRAQSLLQLWQACNNAHAEAAARLEPQERKYQQIANINTSGNNLA
EVLPPALQDAK-ELQCEVQKTKEAFLQNSTLLDRLPQ-PAEPNTHVLLSGQMHSLQRASY
LEKMLLVKTNEFEFVLSQFKDFGDRLESLKGLI-THEEENLDKLYRQEK--EGNPDLFLN
HVLALTAQSPGIEHLNEVSLKLPLSDVAMKTLQNVNRQWIRATATAL-ERCSELQEIGLN
-EK-FLDCCEKWIQLLEKIEETLKANMTDSLPALLEQQKTYEMLEAEVSINQTIADSYVT
QCLQLLDTVEIEKRPEFVWKFTRLKEQWQSAAQGIHQRKSDVDELVRQWRSFT-TSEG-D
LLRFLADTSHLLSAVKSQDCHSLHQTRSLIHELKNKEIHFQRWHTTYALTLEAGEKLLN-
-TANLETKDSVNKKISQLQDNWKDTKLQLGEMIKRFQSTA-ETWDQCEKKIKELKNRLHA
LKAQSKDPLPELHEELHREKELIKELEKSLANWTQNLKELHTMKTDLTQHILVDDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDRLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
AAERTAACPNSSEVLYTVAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDVED--PREIRDDSWRKRAASEE----
PSSPQSLC----QLVPPAL----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAL-----------------------SGKSISEGPS------
------------WHVPDSPSCPKRRYKQMGGDRSVQPIPSDSSTPYKPAYVKLLLSPGT-
EGGKED---PGILTGSAQQ-ED-EDLAALTG-QQ--PGAFDRWELIQAQELHNKLRKKQN
L---QKLNSDISNITPWLEKTGA-ELETLKLSEPPSDMQEMELQVKKLKEILKAFDTYKA
LVVSVNVNSKEFLQSESAESKE--LQDRVSQLTLRWNTALGVVESWREGLRQSLMQCQDF
HQLSQSLLLWLASAESRRQKAH-V-TDPEADPQVLLACQEELMQLEKELVERQPQVNSLQ
EISSTLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLVSLQRSQNPDS-PLPS----
--VD--EVD-HGE--PLAASAPAPQA----------KVRSALTSSV-------ARVPDPA
APE-SSKPQRSFLSRVIRAALPLQLLLLLLLFLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPELPTEDE-QV-SWGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWVNSQLARHTSPSVISDLFKDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLSCN
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQM SAKKALLLWAQQQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAHGTGEEARG-KVKNAM--------VWL
TLQKEKLQKLLKDSENDTYFQKYNS----LLSFMESFSEEKESFLDVLSTKRNLDEPDKD
QLQLEEAWDGLNHQINAWTVKLNCALPPPLHQTEAWLQEVEGLMGEDLSTSQDYSQDTTL
IQEKMTLFKSLMDRFEYHSNNLLTFENRDENHLPLVPPDKLEEMK-RRV-NNILEKKFIL
LLEFHYYKCLVLGLLDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKGFLAQLDTSFQ
KCEEI---YKH------LAGECQNISKQYMAMKSDVCMCRKNIYSMKSTLQTVLAYWATY
VENLRLLRACFEETKKEEIKE-----VPFETLAQWNLEHGTFNEAGNFLIEVSNDVVGSS
ISKELRRLNKRWRKFFSKTQLEMNLPL-I-KKQDQPTFDNSGN----------I-QLSKE
EKSIVEFSTDLSVELPENYNQ--NIK----------------------------------
--------AGEEHEKENEESTGQLKVAKNVEKVIGQ------VEIWEAETKSLLDLLRDH
DDMN--TSMEESLKHLIAKGSMYEELMARTEDMLHVDIQNFSSQES---FQHVLTTGLQA
KIQA-AKEKVQISVVKLVAALKNSTDV-SPELDVRLKMEESQKELESYMTRAQQLLGQRE
SPGGLISKYKEALIISNTESLAKYLKAVEELKNHVTEDIKMSLEEKRRDICATWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHVEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHTTL-----QA
TAG-GT--SGNERTVTTSENKGGDSHSEVLFAKSDNQPSAEK---A-MEPVRNFSLASEL
KPPQEESIM---EKDYSASINSLLERYDTYRDNLEHHLQNSEFRVTSDFSSGEDRSSSCL
QAKLTDLQ-VLKNETDAYWKEFEIISLKLENLANDMKKP-FIVKERGRLKEREQELQMTL
NTRMQSLETARQLVLPVEKAALLLCGSD-MLLHKMAIQEFGLVNADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------YSIAKQIEICNRL-EEPGNYVLKELH
PCDLHAMQNIVLKYKTQFEEMNRRVQRSEDTLRALEGFLESLKTVKLSAEPV-IDLSASD
TQVAQENALTVKNTG-HIHLLKDKARHLDKCLKMLDMSFKDAEQGEGTSCENLVDALSVK
LSETHGCGV-----QENTLLEA-------CIFKNNELLKNIQDVQSQISKIGLKDPTVPA
VKHRKKSLIRLDKDLDEYEEEKKHLQEMANSLPHCKDGREKAVSQQCQNTVLLWENTKAF
ITECLEQCGRVLELLKQYQNFKGILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFHLNKMKTFEEPPFEKEANIIVDRWLDVNEKTEDYYESLG
RALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEELQVHEQKASEFSRRVAE
IQFLLQSSEIPLELQVMESSILSKMEHVQKCLTGESNSYALSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKMNLKECFESSETKRSVEQKLQKLSDFL
TLEGRNSKIQQVDSVLKRVKKHLPKAHVKELSSWLVGQEFELEKMESICQARAKELEDYL
EHLLRLQDDHRNLSKWLMNQEEKWKGMEESGEKTELFYHGLARKREQFESVAQLNNSLKE
FGF-TEE----EEIIMESTCLMDRYQTLLRQLSEIEEEDKLPPMEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWENTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKH
LHESLLQQLQDSVQNLEGHVREHDSYQVCVTDLNTTLDNFSKEFISFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKRNTSSVGQKI-IKDSIKSLKY-KQKDLENR
LESAKQEMEYCLNSIL-KSKCSSEK----KEKF-TLPGTEKQATSDVRDSTQESAAMEKL
EEVWEINM----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVETVMSKQLSLNVQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIKELYTQLEAKKAALEPLEQTECLNKTETGALGLHNAGYSAQHLDNL
LQALTTLKKNKESQYCLLRDFQEHLAAVESSVKALLTDKESLKV-GPLDSVTYLDKIKTF
IATVEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVV
KYGEFTSLMNKIRDTEISL-Q---QQQQHLQLRLKSPEEQAGNRSMIALTTDLQAAKHGF
SILKGQAEFQMKRIWGEKEKKILEDEISNLKKQWESL-DPLNLEAE-----NQIKKCDIR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDAILDRQQAVESLAKEVRDKV
PSLTTCEGSDLNNTLEDLQNQYQTLVLKSTQRSQRLEFKLEERSNFFAIIRKFQLMAQES
ETLITPKVETAA-TEAELKHHHVTLKASQRELQEIDSVISTYLQELTNIYEELNVFERLF
LDDQLKNLKNRTSRTQRLIQNKCNEVEHKINFCREFHEKTLALQEEVDS--IQHNEPL-L
NQ----EVNTGVKEEIYNLKDRLTAIKCSILQVLKLKKVFDFIGLNWDFSQLD---QLQT
VVFEKEKELEEKVKQLDTFEEEHGKYQALLSEMRAIDLQIKKMTEVVLKAPVSSP-ESRL
LNAQILSQRIEKAKCLCEEIIKKLNDNMVFDDSFKEKEILQIKLNAEENGKLYRVL-QNM
ILDLPPKEMDEKHFQDKLETSFHVLNQIKSQLQQPLLINLEIKHIQNEKDNCKAFQEQVW
AEVCSIRAVTAIEKQRE-ENSL-EASDVETKLRDFEDLQMQLTTSVDLRINVLNDACENL
TRYKEAVTRAVESITSLEAIVVHYRIDIGNPEESLEMPLRK-QEELESTIADIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAVKVQETEAE--RYL------ENYKCCRKTEE
DIYTNLSKIETVLGQSMSSLPLSYREALEHLEQSKALVSNLISTKEELIKLRQILRLLRL
RCTENDGICLLKIMSALWEKWLSLLEAAQEWEMWCEELKQEWKFVSEEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYGENMEKQQLLLTLLLQRIRRIQNVPEGSGTVE
T-VPAFQEITSMQERCNQLLQKAQKNKELVQTEIQERHSFTKEIIGLKNLFQQTSTSFQN
MAFQDHPEKAEQVEELQGILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQMEECRKAL
EDIDEKISNEVLKSSPSHAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYSDLLKSTEAWIENTSRLLASPADYDSSKTLSHHASTLQMA-LEDAEQKHSLLHSILMD
LEDLSIIVETDELTQ-SVQELSNQVTALQQKVMKNLPQIQQMADDVVAIESEVKSMEKRV
SKIKTILL-SKEILDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEILSYQVGLRLPQTGMKPLPVFQRTNQLSQDIKLLENVTQEQNEL
LKE-VIKQTNECDEEIENLKQILNNHSAQFSFEHMSPDQAAKLPQLQE-EIEGMEKQILS
LNQKKEDLLVDLKATILNLHQHLKQEEEKAE--RDVLPAVAS-EEGRVAER-DASEWQL-
--NRRGSMSYLAAVEEEAEESSVKSENGDEKAEPPPQT--WSSFWKHDKDE-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILAPDSPNTE---QGSQCSLRTNQTEEGTTPPIK
VATLDSSDTQG-GSEPRV--EKTRPEAAEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLEACKDQGLGDNGATQYEAEALSLKLKTVKCNLE
KVQMMLQEKHIEDQ--HPTIL-KR--SEPEHQKVRQPVNLSELESTVTERPQFSRQKDFQ
QQQ--VQELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKAT-TQESSA----------SNQ
ASSPENDVPDLILSPQGQ-NGDKWQY-----L-RHELSSKIKLPLP-QLVEPQVSTNMSI
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQAQENGTEEMYVNLDKKLFELFLTLS
QCLSSVEEMLQMTGLYREDGSDRQVHY----ETLALELKKLYLALSDKKDDLLKAMTWPG
RNTNLLLECFDNLQVCLEHTQAAAAFRSKSLKAGLDYNHSFQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADAHTVELENSESRVAKLRDEGERLHLPYVLLQEIYKLEEVLD
GMWGILRARYAELSGPVVTESQQDALLQGVVELVKIGKEKLAYDHLKQTKSKVALQAQIE
NHKVFFQKLVADMLLIQTYSAKILPSLLQKRETFWAEQVTEVKILEEKSHQRGMKLQSLL
QKWEEFDENYASLEKDLEILLSTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLVKHLL------SYNR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLYTIRSNINNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLES-GGMPLLEDTASR
IDGLFQKRSSAITQINQLKISMQSVLQEWKIYDQLYDEVNMMTIRFWYCVEHSKPVV--L
SLEALRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQDTH--KR
WTEVNQ---AIADHLQKAQSLLQLWKAYSSAHAEAAARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQNDVQKTKEAFLQNSTVLDRLPQ-PTESSTHMLLPGPLHFLQRTSY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLL-MHEEENLDRLHQQER--E-NPDSFLN
HVLALTAQSPDIEHLNEVSLKLPLSDIAVKTLQNMNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWTQLLEKIEEALQVDVANSLPELLEQQKTYEMLEAEVSINQTIADSYVT
QSLQLLDTAEIENRPEFISEFSKLTDRWQNAVQGVRQRKSDIDGLVRQWQDFT-TSVE-D
LLRFLTDTSHLLSAVKGQEHFSLYQTRSLIHELKNKKIHFQRWRTTYALTLEAGEKLLL-
-TANLETKESMGRRISQLQDNWNDTEAPLAEMIQQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHHEKELIKELEKSLASWTQNLKELQTMKADLTRHVLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKVNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCNDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN----------------------------------------------
--------------------GLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVPPAP----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WHVPDSPSCPKHHYKQTEGDGNVPPVPAESSTAYNPPYGKLLLTPGT-
DGGKED---PGVLNGSPQP-GD-GRLAGITA-QQ--SGAFDRWELIQAQELHKKLKIKQN
L---QQLNSDISTITAWLKKTKA-ELETLKMAKPPSNIQEIELRVKRLKEILKAFDTYKA
SVISVNVSSKEFLQTENAESTE--LQSRLRQLSLLWEATQGMVDSCRGGLRQSLMQCQDF
HHLSQNLLLWLASAENRRQKAH-V-AHPKADPQALLECQRELMQLEKELVECQPRVDLLQ
EISNSLLIKGHGEEYIEAEEKVHVTEKKLKQLREQVSQDLMSLQGTQNPDS-PLPG----
--FD--EVD-SGD-QPLSASMPAPRA-KFR------ERTTEGEEET-----------ESR
VAG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

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----MVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAALIEDELEELHRY
CQEVFGRVSRFHQR LTSLAPGLEEEKEVSENEADMED--PREIQTDAWRKEGESEE----
PTSPQSLC----HLVPPTL----GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----E-D----EEGPYYSAV-----------------------SGKSISDSHS------
------------WHVPDSPSCAKHHYKQMEEDRSEPPIPSDASTPYKAPYVKLLLHPGT-
DGGKDG---LSTLNGSLQQ-EE-EQLASLTG-QH--SGAFDRWELIQAQELHSKLRIKQ N
V---QQLNLIISEITAWLEKTEE-ELETLKMAKPPSDIQELEPRVKRLREILKAFDTYKT
LMVSVNVSGKESLPPESAESTE--LQRRLCELSLHWEAVQGVMDSWRGDLQQSLMQCQDF
HQWSQNLLLWLASAEDRRQKAL-V-TDPKADHQVLLRCQKKLMHLEKELAECQPQVNSLH
EISTSLLTKGNREDYIEAEEKVHVIKKKLQQLREQVAQDLMSLQR----NP-ALPD----
--FD--EVD-ASP----VAFVSAPQAK-VRA----PSFWEN------------------C
AGY-FLKPRRSFLSRVIRAALPLQLLLLLLLLLACLLPASEEDYSCTQANNFARSFYPML
SYTNGPPPT---------------------------------------------------
-

-------MASSPELPAEDE-QG-SLGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINTQLAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX------XXXXXXXXXXXXDGNPSIILGLIWTIILHFHIE----ELARDLSCN
YNQ-----SSQDDVSVAD---SSPTSSPPAKKCSK--AQARWQMSAKKALLLWAQEQCAT
-SES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVAQRSNKDNLKEAFQIAERELKI
PKLLEPEDVDIVNPDEKSIMTYVAQFLKYS KKAPETGDKAQX-XXXXXX--------XXX
XXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXVNTWKAALDGSLPAPLRELEGWLQQAEQLVADGLPTSQLYSEAMAL
TQEKMTLFKDLMGKSDCHLNALLTFENRDERDLPLVPPNKLEEMK-RRI-HNILEKKFIL
LLEFHYYKCSVLDLLNEVRSKLDVWNVKYGNKESVELLLEDWHKFIEENEFLVQLETSFQ
KCEEI---HKN------LAGECQETSEQYKMLECDICVCRK NIDNVKSTLQKVLACWTTY
VENLRLLKACFEETKKEQIKE-----VPFETLSQWNVEHNTLNEVGNFLIEVSSDEVGSS
ISKELRRLNKRWRKFITKTQLEMKLPI-I-KKQDQTIFDSSGNI---------L-LS-KE
EKPTVAVAPDTTIELPGNHTE--HIK----------------------------------
--------IEEEHEKENEEFTGQLKMAEEVEKLIEQ------VEIWEAETKSVLDLLRHQ
DDVD--ASVEDTLQHLIAKGSMYEELVARTEDTLQMDVQNISSRDS---LQHVLRAGLQA
KIEE-AKEKVQINVVKLVSAMNNSTDV-SPTLDIRLQVEEVQKELESYITRAEQLLGQRE
DPSGLISKYKEALIIFNSKSLTKYLKAIEELKNNVTEEVKLSLEGKSREVCAKWEXXXXX
XXXXXX-XXXXXXXKRKLSDNMQTESHIEESIR----REGKGLIKEHE--ACFSEEGSLY
QLDHHMAVLRELSEE-LT--SQKSQQEMKRTLKEYEQKIERLLRNASEIRATL-----QP
TKG-GV--SKNGGTTTTTENGGRESHNEVPCAKANDQSLTEK---X-----XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXYNTHRALELHLQNSEFSITSDFSSEKDRGSACL
QDKLTELQ-SLKNETNAFWKEFETTSLKLENLVNDLKKP-VIVQERESLKVKERELQMTL
NTRMESLEIALQTVLPMEEESLHLCGSE-LPLHEMSIQEFHLTGADDIYQKLRT------
-LQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIARQIEICNDL-GESGNAVLKELH
PFDLHATQNIILKCKTELEEANRKVQMSEDALKDLEDFLASVRTAELSVELV-TDFAASD
IQVAPDSSLMIKNKEAETHLMA-KARSLDERLKMLGLSFRCVEWGEDTSCEKLLDALSIK
SSEPHGHSVQEEVTEEHKLLEA-------CIFKNNELLKNIQDVQNQMSKIGLKDATVPA
VKHRKQLLTRLDKDLDDYEEEKRHLQGMADSLPQLQDGRDQTVNQQCQQTVHLWEQTKAS
VNECLEQCGRVLELLKQYHNFKNVLTNLIQKEENVISLQASYMGKENLKKRIAEIEIVKE
EFSEHLEVVDKINQICKNLQFHLNKMKTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEDLQIYEQKSSEFSRRVAE
IQFLLQSNEIPLELQVMESSILNKMEHMKMYLTGESTCHALGGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNINMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRSSKIQQVDTVLSHVKKHLPKARVKELNSWLVSQEFELENMESVCQVRAKELDDHL
QQLLRLQDEQRNLSKWLANQEEKWKGVEESGEKAELFCQALARKREQFESVVQL-NNLKE
HGF-T-EK---EEVIMESAHLITRYQTLLRQLHEIEEEDKLPTAEDQNFNDLAQDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXXXXXHQEMLLLE------GEKYLQSKEDLRLVLTELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQVCVTDLNTTLD-FAKEFVSFFDDLVHQIAVEEX
X-XXXXELEHRLSLQDGTLKKVSALAKPIKQNTSSAGQTI-IKDDIKSLKC-KQKDLENR
LESAKRETEHCLNSIL-KSKCLTEKEKFPRPGREKQATSD------VQESTQDPAAAEML
EADWGINE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAVEMVLSKQRSLDVQESMKNTKDEQKVNELQNQPL
ELDIMSRNEQLKEMEDLYTQLNAKKTSIEPLEQSECLNTTETSPLDLHNTRYSEHQLDSL
LQALTTLKKNKESQYHRLEDFQESLSAAEYSMKALLTEKESLKV-GPLESATYLDKMEKF
LASVEKEKVSLSKLKIEWETLSNHLTAMDKKLLESQIKQLELGWEQIEQLVQKKHSQQIL
KYDEFTSLMSKIQDIDISL-Q---QLQTCLQSSLNSPEEQEGSQSLIALTTELQVVRNRF
FVLKGQAELQMKRIWGEKEKKILEDAINTLQKQLEAL-EPLNLRAE-----NEIKKCNVR
NEIKEAILWVKNLAGELTAPISLLPDDILSQIRKCKVTHDGILEKQQALDSLVKEIKGNI
PNLTAYESHDLNDILEDLQNQYQILVLKSTQRSQQLEFKLEERSKLFAVVAKVQLTLQGN
ETLLIPKMDTTS-TEAALEHHHAVLKTSQNKLQEIESVVSTHLQELTDIGKDLNVFERLF
LNDQLESLKTRANRTRRFIQNKCSEVEHKVNFCREFREKTSVLQKEVDD--LQHNELL-H
NQ----EINQEVREEFCNLKDRLTGIQSSILQILKLKEVFDCIGLNWDYSHLD---QLYT
QVFEKEKDLEEKIKQLDTFMTEYSKYQASLSKMRARDLEMKKRAEAVLNAPDASP-ESRI
LEAQLLNQRIEKARRFYDEIIKTLSENKAFDDSFKEKEMLQIK-LNTECDKLHQAL-QTM
ILEFQPK-EMVENFHDKLENVLHALNEIKSELQQPFLIDLEIKHVQMEKDKCEMFQEQIQ
AEMYNIKTVTAIKRKREENAP--ETGDAETKLRDIEDLQMQLSTSIDLRINVLDDAYENL
THYKEAVARAVETITSLEAIITSHSVDLDNPEESLEMTHGK-QEELESTITHIQDLTEKL
GAVSSPKAKQQLQCTLRDLVSKNSALKEAATAERAEVE--XXX------XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAMVSNLLSTKEEFGKLRQVLRCLQS
RCTANDGLCVLRTSSALWERWLHLQEAAKEWEMWCEELKQEWKFVSEEXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXXXLLQKTQTNKELVQTEMQERHSFIKEITALKNLFQQSTTSFQN
MSLQDHPEKTGQFEXXXXXXXK-GKLFEHIMKKLRIKYSEMYTIVPAEIESQVEECRKAL
EDLDEKISNEVLRSSPSYAMSRKIEEINNGLQNIEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATIKME
ECSDLLKSTEAWIENTSRLLANPADYDSSKTLSHHASTLQMA-LEDSEQKHNLLHSVFTD
LEDLSIIFETDDLTQ-SIQELSSQVTALQQKIMETLPQVQRMADDVVAIESEVKLVEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIMSYQVELRLPQTGVKPLPVFQRTDQLLRELKLMENVTQEQNEL
VKV-VIKQANECDEEIEKFKQILDNYSAECSLEHMSPDQAANLLQVQG-EIGEMEQQILS
LNQKKEDLLVELKAAVLNLHQHLKQDPQEGE--GDTPSAMAS-EEGGMAER-DASEWKS-
--NRTGSMSFLPAVEEEAEESSMKSENGDKKTDVSTES--WSSLWKHDRDM-EEDRA-SS
SSGTIVQE----AARKISVCDGATTQILALDPLRVE---QGPEFSLRPNQTEEGATPPIK
AAAPDFSDKQG-ALETRV--EKARSEPAEVLHVRKTQIAELELWLQQANVAFEPETLNSD
MQQVVEQQLVGCQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSVKCDLE
KVQRMLQERYSENQ--HPTIQKQP--S--EPHKALPLVSLAELESIVTERPQFSR-QKDF
QQQ--VLELKPMEQKDLVKFIEFN-AKKMWAQDCQRDRAT-TQESSX---------XX-X
XXXXXXXXXXXXXXXXXX-XXXXXXX-----X-XXXXXXXXXXXXX-XXXXXXVTTNMSI
LPSVSAYNFRYPTSEELQAYTTQLEDLRQEASNLHTEENMTEETYTDLDKRLFELFLTLS
QCLGSVEEMLQAPGLFPQAVSAQQVHY----ETLALELKNLYLAMNDKKEDILKAMSWSS
KNTNLLLGCFDKLHVCLEHTQAPAASRGRSLKAGLDYHRIIQNEIKRLYDQLIKNKTSLQ
QSLNEISGQSIGEQLQKADEFMVELQNSESRVVKLRDEGEKLHLPYVLLQEVYKLEDVLD
SMWGILRARCTELSSPSITESQQDALLQGMVELVKIGKEKLARDHLQHTKSQDALRAQIQ
NHKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLEE-SLQHGMKLQSLL
QKWEEFDENYASLEKDLETLLSTLPSVSLVEETEERLVERISFYQQIKSNIDGKHARLYQ
TLNEGKQLTASVSCPELESQIAKLEEQWLSLNKKIDHELHRLHTLLKYLL------SFNR
DSDELTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINTFFEFSKEVDEKSSLKTAVIST
GNQLLHLKEADTATLRASLAQFEQKWTLLITQLPDIQEKLH Q LQMEKLPSRKAITEMISW
MNNVEHQTADGDSVQAPSSAAQVKNLLQKYKEFRMEMDYKQWVVDFVNQSLLQLSTGDVE
SKRYERTEFAEHLGEMNRQWHRVHGTLNRKIQHLEQLLESIAENENKIQTLSNWMEAQEE
RLKTLQKPESGVSIQKLLLDCQDIENQLAMKSKALDELRQSSLTLES-GAMPVLEDTVSG
IDGLLQKQSSVTHQVNQLKTSMQSVLQEWKIYDRLYEEVNMMTIRFWYCMEHSKPAV--L
SLAALSSQVQNLQSLQDEAESSEGSWGKLQEVIGKLKSFC-PSVAEIIQEKCQDTH--TR
WAQVNQ---AIADRLQQAQSLLQLWKTYTSTHAEAAARLGQQEAKFQQLANINLSGNNLA
EILPLALKDIQ-ELQCDVQKTKEAFLQNSVPLDRLPQ-PAESSAHMLLSSQQHSLQRAAY
LEXXXXXXXXXXXFVLSQCKELEDQLESLKSLI-MHEEENLNKLYQQ-E--KENPDLFLN
HVLALTALSPNVEHLNEVSLKLPLSDMAVKTLQAVNRQWIRATATAL-ERCSELQGTGLN
-EK-FIDCCEKWVQLLEKIEETLQGNIADNLPALLEQQKTYEMLEAEVSVNQTVADAYVT
QSLHLLDTAELEKRPEFVLEFSKLVEQWQGAARRVRQRKRAVDGLVRQWQYFT-TSVE-D
LLHFLTDTSHLLSAVRCQDRYSLHQTRSLTHELKNKEIHFQRWKTTYTLTLEAGEKLLS-
-TTNPETKESINKRIGQLQDNWKDTELQLVEMIKQFQSSA-ETWDQCEKKIKELKGRLQV
LKARSQDPLPELHEDLHREKELIKELEKSLANWTQNLKELETMKTDLTRHVLGEDVMVLQ
DQIEHLHRQWEDLCLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-----------------------------------------------XDCME
EINLFSENK-LQLKQMGDQLMKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLK ETF AFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETW RLWQKFLDDYSRFEDWLK
SAEKTAACPNSSEVXXXXXXXXXXXFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDTLQRRVTAVLRRLRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDMED--AREIQTDSWRKRGASEE----
PSSPPSLC----QLVAT------GQERSGCE--TPVSVDSIPLEWDHTGDVGG---SH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTQTLRASSGKSISDGHS------
------------WHVPDSPSCPKHPFKQVEGDRHAPPXXXXXXXXXXXXXVKLLSSADG-
GQ-DS----PRALHGSPQQ-EE-ERLAQIKG-QQPXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXELLKAFDSYKA
LVVSVNVRSKELLQTESAEPSE--LHGRLCQLTLHWEAARAAVDSWREGLRQSLMQCQDF
HQLSQNLLLWLASVENRRQKAH-V-ANPKADPQVLLERQEELMXXXXXXXXXXXXXXXXX
XXSNHLLTKEHGEDYIEAEEKVHVIEKKHKQLLEQVSQDLMSFQGSQNVHP-SLLG----
--FD--EVV-SGD-QPPSTSVPATQA-KFLA---AI-----------------SRGETEV
D-----------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MSVV-D--SSPTSSPPAKKCSK--AQERWQMSAKNALLLWAQEQCAT
-YES-VSVTDFKSSWRNGMAFLAIIHALRPNLIDMKSVKHRSNKDNLKEAFRIAEQELKI
PKLLEPEDVDVVNPDEKSIMTYVAQFLQYSKKAPGTGDKAQG-KMKDAM--------VWL
TLQEKKLQKTLKDSEKETFFKKYES----LLSFLESFNEEKKPFLDILSVKRNPDELNED
QLQMKEAWDGLNHQINVWKMKLNDDLPLPLHQIEAWLHEVEELIDEDLPAFQDYSEAMAL
IQEKITLFKSLMDKSDCHSNTLLAFENRDEKHLPLVPPNKLEEMK-RRI-NNISGKKFIP
LLEFHYYKCSVLGLLDEVKSKLDVWNSKYGSKESVEFLLEDWRKFIEEKEFLAQLETSFQ
KCGEI---HKN------LAGEYQNISEEYAMVESNVCMSRKNIYDVKSTLQEVLASWAAY
AEKLRSLKACFVETKKEQVTE-----VPFETLSQWNLEHTTLNEVGNFLIQVSYDEVGSS
ISKELRRLNKRWRKFITKTQLEMNLPL-I-KKQDQPILDNSGN----------IQLPK--
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-----------------------------------MQDTLVGDGSLNLEKKLFDLLLAII
CCLSNMEEMLRASSLPSEDAVLQQAHF----EALSSELRNLQADVRDKKDELLKTVTRSG
KRSDVFCECFDHLQTQLQLTQAAATSQSQMIKAGLDQNSHYQNEIRLLCDQLTEKKSTLQ
RSLKQISGQSVGEQLQIMDACALELQNYERQVAKLKDEGEKHCLPDVLIQEVYKLEDGLD
DLWGVVRAEHPDLKSPFNLESQAEGLLRGLGEFMVIAREKLAHDQRLQTRSKVALQTQLQ
SHKKFFQKLIADMLLMETHFNRAPHFVLQKPQLLWAEQVKEVTLLEQQAHQRGTQLESLL
QEWEEFDENNASLEKDLEALASSLPSVSLVEETEERLMERIALYQQIKRSIDEKHAQLYQ
TVNEGKQLVSAVGCSALESQIAKLEEQWLSLTQKVDHELHRLQTLLKHLV------SYNQ
NSGALIKWLESAQQTLNYWKEQSLNVSQDLETIRENINRFFDFTKEVDEKSSLKTSVIST
GNQLLHLKETDTATLRASLAQFEQKWAMLITQLPDIQEKLHQLQMEKLPSQRAITETMTW
MKNVEGHMEDETDVDSQSTVSQVKNLLQKYKVFRMEMNYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEQLGEMNRQWHRLHGTLNKKIQYLEQFLENITENENKMQTLSSWMEAQGE
RLKTLQKPASIISVQKTLLDCQELENQLAAKAKSLNELRESYEVLDR-GRGAVLRDSVSQ
VAGLYQMRSELLSQVTALKAYMQSVLQHWRVYDKLYKEVNVVTIQFWYCVEHSKSDV--I
SLEALRRQVKNLQVLQEEAERSEGSWDRLQEAVVQLKDCC-PSFSKIVEQKFQGAR--SR
WTLVNH---EVAEQLQWAQALSQLWESYVTSLTEAMAKLQLQEEKYNQLLAVKTSESNTA
EILTQKLQDVK-ELQQDLQSTREAFLQNSTLVDQLLQ-RAGPTAQGVLSHHSYSLQRISY
LEKMLLIKSNEFEFVLSQLRDFKDRLESLEGHI-KDPVKSLDQLSLQGE--GENPEPTLN
HMLALTALSPDIEYLNKESFKLPLSDVTVKTLHNLNRQWAQATAAAV-EQCSEVQGIQSK
EKK-FLQKYEKWVEFVEKMEETLKMNIAGRPEDLLEQQKIFEMLQGEISVNQHIASSVTI
QSLQLLEAAQIENRTEFISKLTMLKEMWQSVTLRAQQRKNDIDGLVKQWQGFN--TLLKN
LMRFLNGTIHFLTAIKSQDCYRLCEIISLIHDLKNKEIIFQRMQIPYSLTLTAGEQLLN-
-TSDPETKNSLEMKIKLLQDEWKTTRLQLEEELKRLRNIV-ETWDRCEKQIKELGSRLQI
LKEKIKAPLPEQHDELYKDKELIKELETSLSTWAPNLQEVRTPKAALARLLLEEDVLACE
EQIERLHGQWEELCNRVSLRKQEVEDRLNTWALFSEKNTELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCVE
EINLFSENK-LHLKQMGEQLLKASSAARVTEIDDKLNKMNDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDRNMSSL
RTWLARVESELSKPVVYDICDDQEIQRRLAEQQ-DLQRDIEQHSAGVESVFSLCDILLHD
PDACANETECDSIQQTTRSLDRRWRNICAMSMERRLKIE ETWR LWQKFLDDCSRFEDWLQ
SAERTSALPNSSEVLYTNAKEELKKFEAFQRQIHERLTQLELINKQYRRLARENRTDSAS
KLKQRVHEGNRRWDGLQKRVAAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSASDAVEKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPMDAVVIEDELEELHRY
CQEVFGRVSRFYRRLTFRHPSGRKCRHLHSHSRTLFPGTTAEVGFSSHPEARATYR----
GSGLKGLCSGLTELCPPKERFFLSGERVQCR--SS-GTQSLPTGSFHTEGFGGGVNIK--
-----VHK----EYHPFIDDAEGRGIEDGESHGLSDTKGEGVPGQKEDVSMGLVVRW--S
KLRYKEYFDTLLWATLS--LFPKAGFTDISSSSSSRAS--LTVQGLPPAFLPSALGP---
------------------------------------------------------------
---------SHTEQIFWVGAVGCHPLCLLGLVNPPSGLFF---------PIPTSWETLFS
QKCCLLPSQPPVYSPTNPRASSPVTSSHILALPLILCST----PPPAQSFSFHSKRGRDF
HRSSQNLLLWLAEAEKRHCLAQ-I-SDPHADPHALLESQKEFMELEKELSERQLQVNALQ
EISAFLLVKGDGEEYIEADEKIHVIQQKLKRLLEKVSQDLKSTQGLLCVCDLSRTN----
--FK--VLI-SELR-----SFCFQQ---GGA----EGTLEGKVKKD-------SRVERSC
EPGPGSAQRRSFLCRVIRAALPVQVLFLLLLLLACMVPSSEEDYSCTQANNFARSFYPML
S-----------------------------------------------------------
-

--------------------------------------------------EQEHTQKKTF
TCWINSQLAKHVPPSAISDLYTDIKKGHVLLDLLEVLSGQQLTREKGTNPFQCRSNIEQV
LVFLKNRSVSRDFMIKLINIHVTDIIEGNPSIVLGLIWTIILH FHIE----ELAWTLSCS
YNQ-----PSLDCVTVV-D--LSPTSSPPAKRRSK--AQARWKMSA KKALLLWAREQCAP
-HCT-VSITDFKSSWRNGMAFLAVIHALRPDLIDMNIVKDRSNRENLNEAFRIAECELSI
PRLLEPEDVDVLHPDEKSIMTYVAQFLQYSKDLPVAEDESFA-GSRIILNKELNTVTEFF
YLDSST---LAMTDKKVHSGIKNQD----MHSFLETFNEEKKAFLSVLSLKKNMVGMTDD
QLHLREAWDRLTDQINEWRAKLDHILPSPLDRVEAWLQEVEHLMAEDLPAFQDYSNAMTF
VEEKLHLLKGLMDNFDCHLNTLLAFENKDQKHMPLIPPDKLEEMK-KTF-NDVKGTDFIA
LLEFHYYLGSVQGLIDEVKSKLHFWNIKYGTKESVELLLQDWHNFIEKRDVPAQLDASFQ
KLQQNVDNYMK------RGGDPQNISKQFKIVASQISACRKYIYKVKSTLQKVLSSWDTY
TKNLHFLKFSLEESKKEHPKE-----EFFLSNKHLVQAHGNLNEAGNFLMEVSNDQVGLS
IAKDLKKLNRRWAKFIKKTQFELKLQP-V-NKEQKQLLDNNGN----------TELCREE
KLSIPSESIDLSTEVLKRHIR--DLKHHVVLNLPLLKIQTRSNLFLNIQEVWTSLLLKVE
ELLSYLGKIKEENEGEIKESSSLLRRVEEVEKLINQ------VETWEAETRPILNLLQHQ
SSME--GSTEESLQHLIAKGSACRDHISMAEDILQTVTHGVSRQGS---LQHFHTTGLQA
QIEE-AKDKIQVSVKYSGSL-KA-EPS-ASEKEIRVRFEESRKELESCITKALKLLGSKA
SCEDPASEHKEALSILDSKSFDKFLEAAAQQKSISPAHAKLAVEEQSQELCEKWKAVSQE
IVSYICILKVEIEKGKLNEILSKLEKQINKEEKCISKGRTKGLAKQHE--V---------
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-

-------------------------------F-----SLI---------AKQEDTQKKTF
TCWINSQLAKHSPPSVVSDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRTNIGNA
LTFLKNRS------MKLINIHVTDIVDGNPSIILGLIWTIILH FHIE----ELAQTLSCH
YNQ-----PSLDDVSVV-EGGSLPTSSPPAKKCSK--AQERWQMSAKKALLSWAQEQC AT
-HES-VSVTDFKSSWRNGIAFLTVIHALRPDLIDMRSVKHRSSKDNLEEAFRIAEQELKI
PKMLEPEDVDVDNPDEKSIMTYVAQFLQYSRHTAGTRDKPQG-KVKDAM--------LWL
RLQEEKLQKALKDSENETDFTKYCN----LLSFMESFDEEKKFLLDILSKERNLVNLDED
QLQLREAWDGLKYQVNAWKAQLNYALPQPLNEIEAWLQEVEELIGDSLPASQDYSTAMTL
TQERMTLFKSLMDRFDCYSNILLTFENTDEKHLALVPPTKLDEMR-RRL-NNILGKKFIL
LLEFHYYKCSVLGLLDEVKSKLDVWNVNYGSKDSVELLLEDWHKFF--------------
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-

-------MASSPELPTEDE-QI-SWGIDDLHI-----SLQ---------AEQEDTQKKAF
TCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLRNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----KLAQTLPCS
YNQ-----PSLDDVSVV-D--SSPTSSPPAKKCSK--VQARWQVS AKKALLLWAQEQCAT
-YES-VNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKQRSNKDNLREAFRIAERELKI
PRLLEPEDVDVVDPDEKSIMTFVAQFLQYSKDAPGTGEEARG-KVKDAL--------VWL
TLQKEKLQKLLKDPENDTYFKKYNS----LLSFTESFNEEKKSFLDVLSMKRDPDELDKN
HLQLREAWDGLNHQINAWKIKLNYALPPPLHQAEAWLQEVEELMDEDLSASQDHSQAMTL
IQEKMTLFKSLMDRFAHHSNILLTFENRDENHLPLVPPNKLEEMK-RRI-NNILEKKFIL
HLEFHYYTCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKELLARLDTSFQ
KCGEI---YKN------LAGECQNISKQYMMVKSDVCMYRKKIYNVKSTLQKVLACWATY
VENLRLLRACFEEIKKEEIKE-----VPFETLAQWNLEHATLNEAGNFLVKVSSDVVGSS
ISKELRRLNKRWRKLVSKTQLEMNLPLMI-KKQDQPTFDNSGN----------I-L-SKE
EKATVEFSTDMSIELPENSNQ--HIK----------------------------------
--------AGEEHEKEDEEFTGQLKVAKDVEKLIGQ------VEIWEAEAKSVLD----Q
DNVD--TSMEESLKHLIAKGSMYDELMARTEDTLQMDIQNISSQES---FEHVLTTGLQA
KIQE-AKEKVQINVVKLVAALKNSTDV-SPELDIRLKMEESQKELESYMTRAQQLLGQRE
SPGQLISKYKEALIICNTKSLAKYLKAVEELKNNVTKDIKMSLEEKSRDVCAKWESLHHE
LSLYVQQLKIDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGCLY
QLNHHMEVLRELCEE-LP--SQKSQQEVKRLLKDYEQKIERLLKCASEIHMTL-----QP
TVG-GT--SKNEGTISTSENRGGDSHSEAPFAKSDNQPSTEK---A-TEATMKFNLASEL
KPPQKESIM---EKDYSASVNSLLERYDTYKDILEHHLQNNKFRVTSDFSSEEDRSSSCL
QAKLTDLQ-VIKNETDACWKEFEIISLKLENHVSDIKKP-YIVKERDTLKERERELQMTL
NTRMESLETALQLVLPVEKASLLLCGSN-LPLHKMAIQGFHLIDADGIYQHLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSTAKQIEICNRL-EEPGNFILKELH
PFDLHAMQNIILKYKTQFEEMNHKVQRSEDTLKALEDFLASLRIAKLSAEPF-VDLSASD
TQVAQENTLTVKNKEGEIHLMKDKAKHLDKRLKMLDMSFKDAELGEDTSCENLLDALSVK
LPETHGYGVQEELTEENRLLEA-------CIFKNNELRKNIQDVQSQINKIGLKDPTVPA
VKHRKKSLIRLDKVLDEYEEEKRHLQGMANSLPHFKDGREKTVNQQCQNTVLLWENTKAL
VTECLEQCERVLELLKQYQNFKNILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKE
EFNEHLEVVDKINQICKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEGMEKALQKMELHQLTEEDREKLKEELQVHEQKTSEFSRRVAE
IQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHSLSGSTAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFNNIKMNLKECFESSETKKSVEQKLQKLSDFL
TLEGRNSKIKQVDSVLKHVKKHLPKARVKELTSWLVGQELELEKMESICQARAKELEDSL
QQLLRLQDDYRNLSKWMANQEEKWKGMEESGEKTELFCQALARKSEQFESVAQLNNSLKE
YGF-TEE----EDIIMESTCLMDRYQTLLRQLSEIEEEDKLPPTEDQSFNDLAHDVIHWI
KEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAE------SSEAPL
V--QKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIELKK-KQEAG
FALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKD
LHESLLQQLQDSVQNLEGHVREHDSYQVCITDLNTTLDNFSKEFVSFSDKPVDQIAVEEK
L-QKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKI-IKDDIKSLKC-KQKDLENR
LESAKQEMECCLNSIL-KSKRSTEK----KEKF-TLPGREKQATSDVQESTQESAAVEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------DSAVEMIMSKQLSLDAQESMKNTEDEQKVNELQNQPL
ELDIMLRNEQLEEIEELYTQLEAKKAAIKPLEQMECLNKTETGALVLHNIGYSAQHLDSL
LQALITLKKNKENQYCLLRDFQKHLAAVESSVKALLTDKESLKV-GPLDSVTYLDKIKKF
IASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQMEQQIQKKYSQQVL
EYDEFTTLVNKIRDIEISL-Q---QQQQHLHLRLKSPEEQALNQSMIALTTDLQATKHGF
SVLKGQAELQMKRIWGEKEKKILEDGINNLKKQWETL-EPLHLEAE-----NQIKKCDKR
NKMKETILWAKNLLGELIPSISLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV
PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTRRSQQLEFKLEERSNFFAIIRKLQLMVQES
EALIIPRVETTA-TEAELKHHHVTLEASQKELQEIDGGISTHLQELTNIYEELNVFERLF
LDDQLKNLKIRTNRIQRLIQNKCNEVEHKIKFCREFREKTSALQEEVDS--IQHNELL-L
NQ----EVNKGVKEEIYNLKDRLTAIKCCILQVLKLKKVFDYFGLNWDFSQLD---QLQT
QVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSP-ESRL
LNAQILSQRIEKAKCLCDEIIKKLNENKVFDDSFKEKEILQIKLNAEENDKLYKVL-QNM
VLELSPKELDEKNFQDKLETSLHVLNQIKSQLQQPLLINLEIKHIQNEKDNCEAFHEQVW
TEMCSIKAVTAIDKHRE-EENSSEASDVETKLREFEDLQMQLNTSIDLRTNVLNDAYENL
TRYKGAVTRAVESITSLEAIIIPYRVDVGNSDESLEMPLRK-QEELESTIAHIQDLTEKL
GMISSPEAKLQLQCTLQELVSKNSAMKEAFKARKNEAE--RCL------ENYKCYRKLEE
DICSNLSKMETVLGQSMSSLPLSYREALERLEQSKDLVSNLTSTKEELMKLRQILRLLKL
RCTENDGICLLKIVSALWEKWLSLLEAAQAWEMWCEELKQDWKFVSEEIEREAIILDNLQ
EELPEISKTKEAYTTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESSGAVE
T-VPAFQEITSMQERCSKLLQKVQKNKELVQTEIQGRHSFTKEIIALKNLFQQTITSFQN
MAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRKAL
EDIDEKISNEILKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPAQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATVKME
EYNDLLKSTEAWIENTSHLLANPADYDSSRTLSHHASTLQMA-LEDSEQKHSLLHSIFMD
LEDLSIIFETDELTQ-SVQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVKSMEKKV
SKIKTILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIENLKQILNNYSAQFSLEHMSPDQAAKLPQLQG-EIEDMEKQILS
LNQKKEDLLVDLKATVLNLHQHLKQEQEEVE--RDRLPAVAS-EEGGVAER-DASERKL-
--NRRGSMSYLAAVEEEVEESSVKSENGDEKAEPSPQS--WSSLWKHDKDI-EEDRA-SS
SSGTIVQE----AYGKISTCDNSMAQILTPDSLNTE---QGPECSLRPNQTEEGTTPSIE
AANLDSCDAQG-GLEPRV--EKTRPEPTEVLHACKTQVAELELWLQQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLE
KVQMMLQEKHSEDQ--HPTILKKS--SEPEHPKALQPVNLSELESIITERPLFSRQKDFQ
QQQ--VLELKPMEQKDFIKFIEFN-AKKMWPQYCQHDKDT-AQESSA----------SNQ
ASSPENDVPDSILSPQGQ-NGDKWQY-----L-HHKLSSKIKLPLL-QLVEPQVPTNMGV
LPSVSMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYIHLDKKLFELFLTLS
QCLSSVEEMLEMPRLYTEYGSGRQVHC----ETLALELKKLYLALSDKKGDLLKAITWPG
KNTNLLLECFDNLQVCLEHTQAAAVYRSKALKAGLDYNRSYQNEIKRLYDQLIKSKTSLQ
QSLNEISGQSVAEQLQKADGYTVELENAESRVVKLRDEGERLYLPYVLLQEVYKLEDVLD
SMWGMLRARYTELGSPFITESQQDALLQGMVELVKIGKEKLAHDHLKQTKSKVVLQAQLE
NHKIFFQKLVADMLLIQAYSAKVFPSLLQKRETFWAEQVTEVKILEEKSRQRGMKLQSLL
QKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLL------SYSR
DSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNIDNFFEFSKEVDEKSSLKTAVIST
GNQLLHLKETDTATLRASLAQFEQKWTMLVTQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWMEAQEE
RLKTLQKPESVISVQKLLLDCQDTENQLAIKSKALDELKQSYLTLES-GAMPLLEDTASR
IDGLFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVENLQSLQDEAESREGNWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTH--KR
WTQVNQ---AVADQLQKAQSLLQLWKAYSNAHGEATARLKQQEAKFQQLANISMSGNNLA
EILPPALQDIK-ELQHDVRKTKEAFLQNSSVLDRLPQ-PTESSTHMLLPGPLHSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-THEEENLDRLHQQEK--E-NPESFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLYCCEKWIQLLEKIKEALKVDVANSLPELLEQQKTYEMLEAEVSINQTIADSCVT
QSLQLLDTAEIENRPEFISEFSKLTDRWQNAVRGVRQRKGDIDGLVRQWQDFT-TSVE-N
LFRFLNDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRWRTTYALTLEAGKKLLF-
-TTDLETKESVGRRISKLQDNWKDMEPQLAEMIKQFQSTV-ETWDQCEKKIKELKSRLQV
LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDMMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQRRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMED--PREIQTDSWRKRGESEE----
PSSPQSLC----HLVAP------GHERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSISDGHS------
------------WRVPDSPSCPKHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGT-
DGGKEG---PQVLNGSPQQ-ED-GRLAGITG-QQ--SGAFDRWALIQAQELHNKLKIKQN
L---QQLNSDISAITTWLKKTEA-ELEMLKMAKPPSDIQEIELSVKRLQEILKAFDTYKA
LVVSVNVSSKEFLQTESPESTE--LQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDF
HQLSQNLLLWLASAENRRQKVH-V-TDPKADPQALLECRQELMQLEKELVERQPQVDLLQ
ETSNSLLIKGHGEDYIEAEEKVHVIEKKLKQLREQVSQDLMSLQGTQNPAP-PLPS----
--FD--EVD-SGD-QLPTASVPAPRAKFRAA----RTT--AR-----------EEETESR
VPG-STRPQRSFLSRVIRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPAPPTEDE-QV-SLDIDDRHF-----SLQ---------AQQEDTQKKTF
TCWINSQLAKHTPPSVVSDLFADVKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHA
LTFLKDRS------IKLINIHVTDIIDGNPSIILGLIWTIILH FHIE----ELARTLSCN
YDL-----PSLDSVSEA-D--SSPTSSPPAKKCSR--AQERWQISA KKALLLWAQEQCAP
-CES-VSVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKQRSNKDNLNEAFRIAEREFKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLRYSKDAAETRDKAQG-KMKDAV--------IWL
TLQEKKLQKALKDSENETYSKKYES----LLSFLESFNEEKKPFLDILPVKRNLDELDED
QLQLREAWDGLTYQINMWETELNRALPSPLCQIEAWLQKVEELIDEDLPASQDYCAAKAL
IQEKITLIKSLMDKCDCHSNTLLTFENGDEQHLPPVPSKKLEEMK-RRI-NNISGKKFIP
RLEFHYYKCSVLGLLDEVKLKLDVWNIKYGNKESVELLLEDWHKFIEEKEFLAQLETSFQ
KCEEI---HKN------LAGEYQDISEEYTMVEYNVCMYKKYIYNVKSTLQKVLTCWATY
MEKLRLLKACFEETKKEQIKE-----VPFETLSQWNLEHTTLNEVGNFLIQVSNDVVGSS
ISKELRRLNKRWRKFITKTQLEMNLPL-I-KKQDQPDFENCEN----------A-QLPKE
GKPTVDFSRDMSIELPENHNQ--NIK----------------------------------
--------A-GEEREKENEFTGQFQVAEEVEKLIGQ------VEIWEAETESLLELLRHQ
EGVD--ASVEERLQHLIAKGSMYEELMSRTEDILQMDVQNISSQES---LQHVLTVGLQT
KIQE-AKEKVQISMVKLVAALKNSADA-EFNLDVRLKMEESQKELDSYMTRAEQLLGQRE
SQSGLISKYKEALIILNSKSLAKYLKAVEELKNNVTEGVKLSLEEESRVACSKWEALHHE
MSLYIQQLKIDIEKEKLSDNISRLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEMRRALKDYEQKIERLRKCASEIRRTL-----QP
TTG-GT--SKTKETMNTSENGGRDAHREGPSAKSRDQPSTEK----------NFSLKSKL
KPQQEESSMEKSEKDHNAALSCLQERYDIHRENLELYLENNKFRIISDFSSDKERSSACL
QDKLTDLR-VLRDETDSCWKEFEFTSLKLEELDSDIKKP-LIRNTRDRLKEKEREFQMTL
NTRMESLETALKIVLPVEKESLLLCGSD-LLLREIVIQEFHLIDADGIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAGQIEIYNNL-EQSGDFALKELH
PLDLRATREILQKHRTQLEEVNHQVQRSKDALTALEEFLASLRTAELSFEPV-TD-----
TQVVRENMVRAENKEKEISLMKDQARHLDKRLKTLGISFKDAERGDD-TCDKLLVALSRK
LSETCDDGVHGELTEENKLLET-------CIFKNNELLKNIQDVYNQIGKISLKDPSVPA
VKQRKKSLTRLDKDLDDYEEEKKWLQEMVNSLPQFKDGREKSLNEQFQNTALLWESTKAS
VTECLDQCERVLELLKQYQNFKSVLTALIQKEENVISLQASYMGKENLKKRIAEIEIVKE
EFSEHLEVVDKINQICRNLQFHLNKMRIFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFNLKNVIDEWTEKVLRKMELHQLAEDEREKLKEELQAYEQKSSEFSTRVAN
IQFLLQSSEIPLELQVMESSILNKIENVKTHLIGESACSALSGSPAELREDLDQAKTQIG
MTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMMLLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIKMNLEECFESLETKKSVEQKLQKLSDFL
TLEGRGSKIQQVGTVLNHVKKHLPKAHVKELNSWIINQEIELEKMESVCQARAKELNDYL
QQLLRLQDDHSNLSKWLTSQEEKWEEMEKSGEKTELFCEAVARKREQFESLAQMTSSLKE
CGL-TEE----EEIVMESAHLIDRYQAFLRQLCEIDEEDKLPPTEDQSFNDLAHDVIRWI
AGIKESLMALNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTIMSQAE------SSKSPL
A--PKTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQHGLQEKKAQLKIYKKFLQKAQDLTSLLKELKSQGSYLLECTKNPNFSEKPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHHSYQLCITDLNATLDDISKEFASFSDMPGDQIGVEEK
L-QKLQELENRLRLQDGTLKQILALANSIKQNTSSVGQKI-IKDDIKSLMC-KQKDLENR
LESAKQETENCLNSIL-NSKRSSEQ----REKF-TPPGREKEVTSEVHESTQDSNALEKF
EEDCKINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSTVEVVLSKQLSLDVQESMKNTEDEHKVNELQNQPL
ELDVMLRNEQLKEIEELYAQLEAKKTAIEPPEQTECLDKAETSALVLHNTGHSVHHLDHL
LQALRTSKKNKESQYYLLNDFQEHLASVETSVKALLTEKESLKV-GPLDSATYLDKIKKF
LASVEKEKGSLSKMKIEWENLSKCLTDMDKKLLESQIKQLAHSWEQVKQLAQKKYSQQAV
EHEEFTLLMSEIQDLGSSL-QQQQQQQQCLQFGPDSPEEEAGCAHMVALATELQIIKHQF
SVLKGRAEFQMKRIWGEKEKNTLEGAVDNLQKQLEAS-EPLNTQVE-----NQIKKYEIR
NKMKEMMLWVKNLLGELTPPISLLPDDILSQIRKCKVTHDSILEKQQAMESLVEEVKNNI
PNLMAGESNDLNHILQDIQNQYQMLILKSTERSQQLEFKLEERNRFIAVIEKVQLSLQEN
EALIIPKVRTAS-TQAELELEQATLTRSQEELQEAQGIIAAHLQEQTPVCKDLSVFERLF
LDDLLKNLKTRANRTQRFIQNKWNEVEQKRDFYREFHEKASVLQKEVDH--IQRNELL-L
TQ----DINGDVKEELYGLKDRITGIQSGILRLLKLKEAFDSMGLNWDCSQLD---QLQA
LVFEKEKELEEKIKQLDIFMAEYGKYQASLNKLRAVDLQIKKRAEAVLGTPPTSP-ESSL
LSAQILKRRIEKAMCLCQEIIKKLNESKAFDDSFKEKEILQIKLYAEENDRIHKIL-QNG
ILKSQPQEMDEKDFQDKLENSLHVLNQIKAQLEQPLLLNLDIEHIQNEKENCEVFHEQVQ
AEVDGVKAVALTEKQRD-ENSS-DACDVETKLRDIEDLHAQVNTSIDMRTDVLNDACESI
THYNEAVIRAKGILTAREAIVASHKVDLDNPKAPLEMPGWK-QEELQSTIADIQDLTEKL
GTTSSPEAQQQLQSTMQELLSKDSAMTEAAKVKERELE--RCL------ENYKCYRRIKE
KICSDLNQMEAVLRQSVFPLPASYKEALERLEQSKALGSKLLSTKEELMKLRQVLRHLRP
ACTDSDDMCLLRTTTDLWDKWLNLLEATKEWEIWCEELKWEWKFVSEEIEREAIILDCLQ
EDLPEISKTKEAATTEELCELQDSLCRYQENVEKQQLLLTLLLQRMRSIQNAPKSLEAVE
M-IPAFQEITSMQERCNKLFQKAQENKELMENEIQERHSFTKEIITLKNLFQQTATYFQN
MELQDHPEKVDQFEELQSIFKKGKLTFENIMEKLRIKYSEMYTLVPAEIESQVEECRKAL
EDVDEKISNEVLKSSPSYTMSRKIDEINNGLHSVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHCKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLRSTEAWIENTSHLLASPTDYDSSKELSQHASTLQMA-LEDSEQKHNLLHSIFTD
LEDLSIIFETDDLAQ-SVQELSRQVAALQQKIMESLPQIQRVADDVVAIETEVKSVEKKV
SKIKAVLL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPVKKAIAELMSYQVELQRPQAGMKPLPVFQRTNQLLQDIKLLDNVTREQNEL
LRI-VIKQTDECNEDIENLKQILNNYSAEFSHECVSPDQAANLTEAQG-DIEGMEKQILS
LNQKKENLLVDLKAAILTLHQHLQQDQPALE--QEMLSSGAS-EEEGVAER-D-SEWKV-
--NKTGSMSFLPALTEEAEESSLKSENGDKKAEPSSGS--WSSLWKHDRDV-EEDRA-SS
SSGTIVQE----AAEKISTCDNPVAQSLTSDSPS-------------PNQREEGATPPLK
AAALGFSDKQG-AFESTV--EKFGPEPAEILHACKTQVAELELWLHQANVAFEPETLDAD
MQHVVEQQLVGCQAMLTEIEHKVASLLESCKDRGPGDSGATQQEAEALSVKLKTVKCNLE
KVQIMLQEKHSEDQ--HSAILKRP--S--EHQNDLQPDNLSAFESIVTERPQFGRQRDFQ
QQQ--VLELKPMEQKDFIKLIENN-AKKMWPQHCQPGKDT-TQQSSE----------SIR
ASNPENDAPDSVLSAQGH-SGDKWQY-----L-HHELSSKLGLPLP-KQVQPQVATNMSV
LPSVSVYNFRYPTTEELKIYTIQLEDLRQEASNLQTQENLTEETYINLDKKLFELFLTLS
QCLGSVEETLQTPGLFRGDVCAQQVHY----ETLALELKKLYLAMGDKKNDLVKAMAWPG
SNTSLFLECFNNLQVYLEHTQATATAKSKSLKAGLDYNRSYQNEIKRLYDQLSKYKTSLQ
QSLNEISGQSIDEQLQKADACTVELRNSENRVAKLRDEGERLRLPCVLLQEVYKLEDLLD
SMWGILRARYMELSSPFITESQQDALLRGMAELVDIGKEKLAHNHLQQTKSKAALQAQIQ
NHKLFFQKLVADMLLIRTYANKMLPSLLQKKEMFGAEQIKEVKLLEEKSHQCGIKLQNLL
QKWEEFDENYTSLEKDLEILVSTLPSVSLVEETEERLAERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLALNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINKFFEFSKELDNKSSLKAVVVST
GSQLLHLKEADTATLRAALAQLEQKWTTLVTQLPDIQEKLHQLQMEKLPSREAITEMISW
MNNVERHIVGEDSERSLSSAPQVKNLLQKYKEFRMEMDYKQWIIDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQRVHGTLNRKIQHLEQLLESITENENKIQILNNWIEAQEE
RLKTLQKPASVISVQKTLLDCQDIENQLAVKSKALDELRQSYLTLES-GTVPLLEDTTSR
IDGLFQKRSSVINQVNELKTSMQSVLQQWKVCDKLYEEVTMMTIRFWYCMEHSKPVV--L
SLEALRCQVESLQSLQDEAEGSEGRWVKLQEVVGKLKDRC-PSVAEIMEEKCQSTH--AR
WTQVNQ---DIADQLQKAQSLLQLWKAYNSAHTEATVRLEQQEAKYQELENINMSGNNLA
DILTPALQDVK-ELQHDVQETKEAFLQNSTLLDRLPQ-LPESGTHVPRSAQLYSLQRAAY
LEKMLLVKANEFEFVLSQFKDFGDRLESLKGLI-MREEENLDKLYHQEK--EENLDLFLN
HVLALTAQSLAVEHLNEVSLKLPVSDIAVKTLQNMNRQWIRATATAL-EHCSELQGTGLN
-KK-FLYCCEKWVQLLEKIEETLEVNVADSLPALLEQQKTYEMLEAEVSINQTVADSYVT
QCLQLLDTTEIEKRPEFISKFTKLKDRWQSAAQRIRQRKSDIDGLVGQWRYFT-TAAE-D
LLRFLNDTCHLLSALKGQDCHSLHQTRRLIRELKSKEIHFQRRQTTFELTLEAGEKLRN-
-TTSLETKEMIDKKISQLGDTWKDTKLHVEELIKQLQSNV-ETWDQCEKKIKELKSRLQV
LKAQSRDPLPELHEDLHREKELIKELEKSLGDWTQNLKELHTMKTDLTRHILVDDVMVLK
EQTEHLHRQWEDLCLRVAIRKQEIEDKLNSWVVFSEKNKEMCAWLVQMENKILQIADIGI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKHMGEQLRKASNKTRAAEIEDKLNKVSDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
SAERTAAYPNSSEVLYTNAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
RLKQMVHEGNQRWDNLQKRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEEEKEASENETDMED--PREIQADSWRKRRASEE----
PSSPQSLC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EDD----EEGPYYSALSDVEIPENPEAYLKMTTKTLKASSGKSIPEDHS------
------------WHVPDSPSCPKLRYKQMGGDRNVQTIPSDSSTPYKPAYVKLLLSPGT-
DGGKEG---SRVLNGSSQQ-ED-EGLAALGV-QQ--SGAFDRWELIQAQELRNQLRIKQN
L---QQVNSEIRDVTTWLKETEA-ELEMLKRAQPPSDIREMELRVKRLKEILKAFDTYKA
LVVSVNMSSKELLQTESAESGE--LQARVGQLGRRWDMVRGAVESWRAGLRRFLLQCQDF
HQLSQDLLLWLASAESRRQKAQ-V-TDPNADPQVLLECQEELMRLEKELGERQPQVNTLR
EISDSLLVKGRGEDYIEAEEKVHVIEKKLKQLLEQVSQDLMSLQGRQNPDP-SLPS----
--LD--EED-GGD-QPPAASTPAPPAKFGAE-----RMTTDKSKTD-------SRVPGPA
GPS-SSRPQRSFVSRVIRAALPLQLLLLLLLLLACLLPFSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

-------MASSPVLPTEDQ-PI-SLGIDDLHI-----SLQ---------AEQEDTQKKTF
TCWINSQLAKHDPPSVISDLFTDIKKGHVLLDLLEVLSGEQLPRDKGSNTFQCRINIEHA
LTFLKNRS------IKLINIHVTDIIDGNPSIILGLIWTIILHF HIE----ELARTLSCN
YNQ-----PPLDSVHEV-N--SSPTSSPPAKKCSK--VQERWQM SAKKALLLWAQEQCAT
-YES-VSVMDFKSSWRNGMAFLAIIHALRPDLIDMKSVKQRSNKDNLKEAFRIAEQELKI
PKMLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGSGDKSQG-KMKDAM--------VWL
TLQEKKLQKMLKDSENETYCEKYES----LLSFLELLNEGKKPFLDVLSIRKNLDELNED
QLQLREAWDSLNYQVNAWKADLNHVLPPALYQTEVWLQEVEELVEEDLPASQDYSEARAL
LQEKMTLFQSLMDKFDCHLNTLLAFENRDENHLTLVPPNKLEEMK-RRI-NNISGKKFMP
LLEFHYYKCSVLGLLDEVKSKLVVWNIKYGSRESVELLLEDWHKFIEEKQFLAQLETSFQ
KCEEI---HKN------LAREYPDISKQYAMVEHHFCMYRKNIFNAKSTLQKVLACWATY
MENLRLLKASFVETKKEQMKE-----VAFE-LSQWNREHTTLNEVGNFLIQVSNDEVGSS
VSKELRRLNKRWRKFITKTQLELNPPL-I-KKQDEPSLGSSGD----------I-QFSNE
EKSTVDFSTDMSIELPENHNQ--NIM----------------------------------
--------AGKEHEKENEEFIGQLNVAEEVEKLIGQ------VKIWEAETTSLLDLMRQQ
DDGD--TSVEGSLQHLIAKGSMYEELVSRTEDSLQMDIQNVSSQES---FQHVLTSGLQA
KIQD-AKEKVQINMVKLAAVLKNSTDV-SPDLDVRLKVEESQKELESYITRAEQLLGQRE
SQSRLISKYKEALIIFNTKSLAKYLKAIEELKSKVAEDVKLSLEEKSRDVCAKWESLHHE
MSLYIQQLKIDIEKGKLSDNIAKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDRHMEVLRELCEE-LT--SQKSQQEVRRALRDYEQKIERLRRCASEIQTTL-----QP
AAG-GT--VRNKGTPDTSENGGRQALSEVPSAKSDNQPSTKK---A-MESIKNFSLESSL
KPQQEESVMGTYEKDHSASINSLLERYDAQRETLELHLQNNIVRITSDFSSDEERSSVCL
QDKLTDLQ-VLKNETDACWEEFEMTSLKLEELESDMKKP-FIVKARDELKEKERELQMTL
NMRMESLEAALKVVSPLERESVLLCGSD-LLLCEVTLQDFHLSDADDTYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSIAEQIEICNTL-EQPGNFALKELD
PLDLRAAQNIILKHRMQLEEMGHRVQRSKDALKALEDFLASLRAAELSGEPF-TDLSAPD
SQVVPENTSTVERKEGEIHWMKDKARHLDISLKMLGISIRDTERGENTSCEKLLDTLSKN
SSETRGSGGQKELTEEEKLLET-------CIFKNNELLKNIQDVHSQISKIGLKDPTVPA
VKQRKKSLIRLDTELDGYEEEKKHLQEMVNSLPPFEDGREKALSQQCQDTAFLWENTKSS
VTECLDQCERVLELLKQYQNLKSVLTTLIQKEETVISLQASYMGKENLKKRIVEIEVVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFDLKNGIDEWSEKVLQKIELHQLAEEEREKLKEELLVHEQKPSEFSKRLAK
IQFLLQSSEIPLELQVMESSILSTIEQVKMRLMGESSCCALGGSTAELREDLDQAKTQIG
MTESLLNALSPSDSLEIFTKLEEIQQQIRQQKHSMVLLESQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGNIKMSLKECFESSETKKSVEQKLQKLSDFL
TLEGRGSEIQQVVTVLDHVKKHLPKAYVKKLNSWIVSQEIELEKMESICQARAKELDDCL
QQLLRLQEDHRNLSKWLANQEEKWKEMGGSREQTELLCQTLARKSEQFETIAQMNDSVKE
YGL-TEE----EEIVMESTRLIDRYQTLLRQLRETDEEDKLPPAKDQLFDDLAHDVIHWI
TGIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDAKIQTIMSQAE------SSKAPL
V--PQTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEMG
FALQPGLQEKKAQLKIYKKFLQKAQDLTSLLEDLKSQGNYLLQCTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHDSYQVCITDLNTALDSISKELVGFSDKPVDPIAAEEK
L-EKLQRLENSLRLQDGPLEKIFALAKSIKENTSSAGQKV-IKEDIKSLKC-KQKDLENR
LESAKQEMEDCLNSIL-RSKCSAEK----EEKF-TPPGREEQVTS------QDSAAGEKL
EEDWEINT----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSAMEMVLSKQLSLDVQESMKNTEDEQKVNELQNQPL
ELDVMLRSEQLKEIEDLHTQLEAKKAAIEPLEQTEYLNKTGTSALVLHNERYLVHHLDRL
LQALTTLKENKERQYCLLKDFQEHLAAVESSMKALLTEKESLKV-GPLDSATYMDNIKKF
LVSIEKEKDSLSKMKIEWENLSNCLTDMDKKLLESQIKQLEQSWEQVEQLVHKKYSQLVV
EQDEFMFLMSMIQDLEISL-Q---QQQQCLQFRLNSPEEEEGNQSMVALATELQTVQHRF
SVLKGRAELQMKRIWGEKEKKILEDAINNLQKQLEAL-EPLNVQVE-----NQIKKCETR
YKMKETILWIKNLLGELIPTISLLPDAILSQIRKCKVLHDVILDKQQVVDALVQEVKDNI
TNLTAYESSVLNNLLQDLQNQYQMLVLKSTQRSQQLEFKLEERSKFVAIIGEVQLSLQRN
EALIIPKVEIAS-TEAELEQEHVTLSTSQKELQEIESVISRHLQEKTSICKDLSVFEKLF
LDDQLKNLKTRANRTERFIQNKCNEIEHKINLYREFHEKASVLQKEVDH--IQDNELL-L
NP----EISQDVKVGLSSLKDQITDIQSSIQQVLMLKEVFDCIGLKWDWTQLD---QLQT
QVLKKEKELEGKIKQLDTFLAEHDKYQASLGKLRAMDLQVQKRAEAVLTTPSTPP-ERNL
LSAHILNLKIGKVMCSYHEIIKKLSENKAFDDSFKERELLQIKLYAGENDKLHKVL-QNM
VLEFQPKEMDEKSFQDKLENCLHVLNQIKSQLQQPLLIHLKIEHIQNEKDRCEAFQEQVQ
AEMYSIKAVTLIEKQTE-ENSS-EAIEVEAKLRDIEDLHMQLNISIDLRINVLKDAYESM
MSYDEAVSRAMEILTVLEAFSASYRVDLHNPEESLEMTRCK-QEELESTLAGIQGLTENL
GTISSPEAKRQLECTLQKLVSKNSAVREAAKVKEAEVE--RCL------ENYKHYRKIKE
KLCTNLNQMETILGQTMAPLPVSYKEALERLEQSKALVSDLMSTKEEFMKMRRVLRHLGS
TCTHSDSLSLLRSMSALWERWLRLLEAAKEWEMRCEELRQEWKFVREEIEREAIILDNLQ
EELPEISKTKEAATTEELSELLDCLCQYEENVEKQQLLLALLLQRIKNIQGVPEGLGSVE
T-VPASQEITSMQERCNQLFQKAQKIKELMQNEIQERRSFMKELITLKNFFLQTATSFQN
MELQGHPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAELASQVEECRKAL
DDVDEKISNEVLKSSPSYTMSRKIDEINNGLRNVEKMLQQKSKNIDKAQEIQKKMWDELD
LWHSKLNELDSEVQDLVEQDPGQAQEWMDNLMVPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWVENTSRLLADPADYDSSKTLSHHAGTLQMA-LEDSEQKHNLLHSVFTD
LEDLSIIFETDDLAQ-SIQELSRQVTSLQQKIMESLPQIQRMADDVVAIETEVKSMEKRV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPPAGMKPLPVFQRTSQLLQDIKLLENVTQEQNEL
LKV-VIKQTNECDEEIEKLKQILNDSSAEFSHEHMSPDQAVDLPQVQG-EIEGMEKQILS
LNQKKEDLLVDLKAAIINLHQHLQKKQQELE--KEVLSAGTS-EEDGEPGK-EASEWKL-
--NRTGSMSFLPAVVEEAEENSLKNESGDKTAEPSSGS--PSLLWKHDKDV-EEDGA-SS
SSGTIVQE----ATGKISICDSSMAQILVPDSLNTE---QGPELSLSPDQTEEGATPPIK
AAAPGFSAEQG-ALEATV--EKARPEPAEVLHVCKNQVAELELWLHQANVAFEPETLNAD
MQQVVEQQLVGCQAMLTEIEHKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYNEEQ--NSTILKKS--S--EHQKVLQPDNLSEFESIVTERPQFSRQKDFQ
QQQ--VLELKPMERNDLIKFIEFN-ANKMWVQYCQHAKDT-TQTSSV----------S-K
ASSPENDAPDSVLSAQGQ-SGDKWQY-----L-HHELSSKTRLPPP-QPVQPQIAANMSV
LPSVSVYNFRSPTPEELKTYTTQLEDLRQEANTLQTQENMSEETFMDLDKKLFELFLTLS
QCLGSVEEMLQTPGLFRGDAGAQQVHC----ETLALELKKLYLALSDKKNDLLKAMTWPG
KNTSLFLDCFDKLQVYLEHTQATMASRSKSLKAGLDYSRSYQNEVKRLYDQLIKNKTCLQ
QYLNEISGQSIDEQLQKADAYAVDLQNSESRVAKLREEGERLHLPYVFLQEVYKLEDVLD
TTWGILRARYAELSSPFVTESQQDALLQGMVELVNIGREKLAHDHLQQAKSKAALTAQIQ
NHKLFFQKLVADMLLIQTYSNKM-PPLLQKKETSWAEQVKEVKLLEEKSHQCGIKLQSLL
QKWEEFDEKYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIDEKHARLYQ
TLNEGKQLVASVSCPELEGQIAKLEEQWLALNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNASQDLETIRSNINNFFEFSKELDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQKWTVLITQLPDIQEKLHQLQMEKLPSRKAITEMISW
MNNVEHQTADEDSEQSLSSASQVKNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQLHRVQGTLNGKIQHLEQLLESITENENKIQILNNWMEAQEQ
RLNILQKPESVVSVQKMLLDCQDIENQLAIKSKVLDELRQSYLTLES-GTVPLLEDTASR
IDELFQKRNSVIKQVSELKTSMQSVLQEWKIYDKLFDEVNMMTIRFSYCVEHSKPLV--L
SLEALKYQVQNLQSLQDEAESSDGTWKKLQEVIGKLKDHC-PSVAEIIQEKCQNTH--TR
WTQVNQ---DLADQLQGAQSLLQLWKACSSAQAEAATRLEQQEAKYQQLANINMSGNNLA
EILPPALCDIK-ELQHDVQKTREAFLQNSILLDRLPQ-PAESNTHMLLAGQLHSLQRASY
LERMLLLKTNEFEFVLSQFKDFEDQLESLKGLI-THEEENLDKLYQQEK--EGNPDLFLN
HVLALTAQSPDIERLNEISLKLPHSDIAVKTLQNMNRQWIRTTATAL-ERCSELQGTGLN
-EK-FLYCCEKWVQLLEKVEEVLKVNIADSFPALLEQQKTYEMLEAEVSINQIIADSFVT
QSLQLLDTTEMDRSPELVSKFMRLKEQWQSAVQGVRQRKSDVDGLVRQWQYFA-TSER-D
LLRFLADTSQLISAVRSQDRYSLHQTRSLMHELKNKEIHYQRWQITYALTLEAGEKLLN-
-TTNLETKESIDKRLGQLQLTWKDTELQLGEVIKQFQSMA-ETWDQYEKKIKELKNRLQV
LKAQSKDPLPELHEDLHREKLLIKELEKSLANWAQNLKELHVMKTDLTQHLLVEDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQLGDRLIKASNKTRAAEIDDKLIKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIECELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLQ
PAEKTAAFPNSSAVLYTIAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAVLRRLRHFTSQREEFEGTRESILVWLTEMDLQLTNVEH
FSESHADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVVIEDELEELHRY
CQEVFGRVSRFHRRLTSPGPGLEDEKEASENETDMED--PREIQDDSWRKRGESEE----
PSAPPALC----HLVPPAP----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPFYSALSDVEIPENPEAYLKMTTKTLKASSGKSISEGHS------
------------WHVPDSPSCAKRRYKQMGGDRNVQPIASDSSTPYKPAYVKLLLSPVT-
GGGRED---PRALNGNPRQ-ED-EGLAPLTR-QQ--SGDFDRWELIQAQELHKKLRIKQN
L---QQLNSSISDITTWLEKTEA-ELETLKLAEPPSDMQEIELRVKRLKEIVKAFNTHKA
LLVSVNVSSKEFLQTESADSKE--LQDRVSQLSLRWDAAQEAVESWREGL RQSLMQ CQDF
HHLSQNLLLWLASAESQRQKAH-I-RDPEANHQALLVCREELTQLEKELVARQPQVSSLR
EISNSLLTKGHGEDYIEAEEKVHVIEKKFKQLLEQVSQ DLMSLEGSQNLGS-SLPS----
--LD--EAN-P-E-EPVAASSPASEA-KLRA----ERTRRDKNRTD-------SRVPSST
HPN-SSRAPRS FLSRVIWAALPLQLLLLLLLLLACLLPASVEDYSCTQANNFARSFYPML
RYTNGPPPR--RGPARSPGPVCEGPERWSRDLPPTDTSLWQ-------------------
-

-------------------------------------------------AEQEDTQKKTF
TCWINSQLAKHTPPSVVTDLFTDIKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIENA
LTFLQNQS------IKLINIHVTDIIDGNPSIVLGLIWTIILH FHIE----ELARTLPGN
YSQ-----PSLDSVSAV-D--SSPTSSPPAKKCSK--VQERWRMSA KKALLQWAQEQCAS
-YES-VNVTDFKSSWRNGMAFLAVIHALRPDLIDMKSVKHRSNRDNLKEAFRIAEQELKI
PKMLEPEDVDVVNPDEKSIMTYVAQFLQYSKKAPGSGDEAQG-KVKDAM--------VWL
ALQEKKVHKMLTDSENETYCKTYES----LLSFLESFNKEKERFLDVLTIKRNVDDLNKD
QLQLREAWDGLNYQINVWQTELNRVLPSPLYQIETWLQEVEKLIDEDLSVSQDYSEAMAL
TQEKITLFQSLMDKFDCHLNTLLAFENRDENHLPLVPPEKLEEMK-RRI-NNISGKKVIP
RLEFHYYECSVLGLLEEVKSKLLVWNIKYGSKESVELLLEDWHKFIEEKEFLAQLETSFQ
KCEEI---HNN------LAGEYPNISKQYTMVKYHFSMYRENILNVKSTLQKVLACWATY
VENLRLLKACFEETKKEQMKE-----VPFETLSQWNLQHTTLNEVGNFLFQVSNDEVGSS
ISKELKRLNKRWRKLITKAQPEVNLPL-M-KLQDEPFLDNSGN----------I-QLSKE
ENLAVGFST----------YR--SIN----------------------------------
--------AGEVHEKENEDFSGPLKVAKEVEKLIGQ------VETWEAETTSVLDLLRQQ
DDVE--TSVEESLQHLIAKGSMYEELVSRIEDTLQMDVQHVSSQES---LQHVLTAGLQA
KIQE-AKEKVQISMIKLVAVLKNSTDV-SQDLDVRLKVEETQKELESYITRAEQLLGQKE
SQRGLITKYKEALIISNTKSLAKYLKAVEELKNNVTDDVKLSLEEKSRDICAKWESLHHE
MSLYIQQLKIDIEKGKLSDSIAKLEKQINKEKKLIRRGRTKGLIKEHE--ACFSEEGSLY
QLDHHMDVLRELCEE-LT--SQKSQQEVRRALKDYEQKIERLRKCASEIHMTL-----QP
TLG-GT--SKNKGTTDASKNGGGNTLSEVPSAKSDNQPSAEK---A-MELVQNFHLESKL
KLQQEESIMEKYEKGHSTSIDSLLERYDTHKGTLELYLQNSIARITSDFSSDKERSSVCL
QDKLTDLQ-VLKNETDACWKEFEITSLKLEELESDIKKP-FIVKARDKLKEKERELQMAL
KSRMESLETVLKMVLPMEKESLLLCDTD-LLLREMAIQEFHLTDADDIYQNLRN------
-IQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------DSVVKQIETCKNL-GQSGNFALKELH
PLDLHAAQNIILKHRTQLEEMNHRVQKSKDALEALEDFLASLRAAELSSELL-TDHSASD
SQGVPANTLTVENKEREIHRMRDKARHLDEHLKMLGISIKDSEQGENTSCEKLLDALSKN
LSETR-SGGQEEVTEEDKLLGA-------CVSKNDELLKNIQDVHNQISKIGLKDPTVPA
IKQRRKSLIRLDKDLDEYEEEKKHLQEMVNSLLQFKDGRNKALSQRCQDTAVLWENVKTL
VTECLDQCERVLELLKQYQNFKSVLTTLIQKEENVLSVQASYMGKENLKKRIAEIEVVKE
EFNEHLEVVDKINQICKNLQFHLNKMRTFEEPPFEKEANIIVDRWLDINEKTEDYYENLG
RALALWDKLFDLKNGIDEWTEKVLQKLELHQLTEEEREKLKEELQVHEQKPSEFSKRVAK
IQFLLQSSEIPLELQVMESSILNKIERVKMCLMGGSHCGAISGSTAELREDLDQAKTQIG
MTESLLNALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVS
DLFNTKKSVLQDHFSKLLNDQCKNFNDWFGSIKMNLKECFEPSETKKCVEQKLQKLSDFL
TLEGRGSEIQQVGTVLNHVKKHLPKAPVKKLNSWIVSQEVELEKMESICQARAKELEECL
QQLLRLHNDHRNLSKWLTNQEEIWKEMEGTREKTELFCQAVARKREQFESMAQLNNSVKQ
YGI-TEE----EEIVTESTHLIDRYQTLLRQICETDKEDKLPPAEDQSFNDLAHDVIHWI
TGIKESLMVLNSSEGKMPLEERIHKIKEIILLKPEGDAKIQAIMSQAE------SSKTPV
V--PQTLTDIKNQWDNTLHLANTYLSHQEKLLLEGEKYLQSKEDLRLMLTELKK-KQEVG
FALQPGLQEKKAQLKIYKKFLQKAQDLTFLLEELKSQGNYLLECTKNPNFSEEPWLEIKH
LHESLLQQLQDSVQKLEGHVQEHDSYQLCITDLNTALDYIAKEFVCFSDRPVDERVVEEK
L-QKLQDLENSLHLQDGPLEKILTLAKSVKQNTSSAGQKI-IKDDIKSLKC-KQKDLENR
LASAKQEMENCLNSIL-KSKCSTEN----KAKF-PLPGREEQVTSDVQESTQDSAAMEKL
EEDWEINK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------NSALEMILSRQLSLDVQESMKNTEDEQKVNELQNQPL
ELDVMLRNEQLKEIEELCTQLEGKKAAIEPLEQSEYLSKTESSALVLHDESYSVQHLDNL
LQALITLKKKKESQYCLLEDFQGHLMAGESSMKALLTEKESLKV-GLLDSTTYMDKIKNF
LASIEKEKDSLSKMKIEWENLSNCLTDMDKKLLESQIRLLEHGWEQMKQLAQKKYSQQSV
GHEEFMFLMSKIQDLETSL-Q---QQQQHLQLRLNSPEAQEGNLSVVALATELHTIKHRF
SMLKGRAELQMKRIWGEKERKILEDAISNLQKQLEAL-EPLNMEVE-----NQIKKCETR
YKIKEAILWVQNLLGELTPPISLLPDDVLSQIRKCEVVHDGILAKQQVVESLVEEVKDNI
PNFTAYESNDFNNLLQDLQNQYQMLALKSTQRSQQLELKLEERSKFVAIIGKVQLSLQGN
ETLIIPKTDTTS-TEAELEQLYVALTTSQKELQEIKSVISTHLQEQTNISKDLSVFERLF
LDDRLKNLKTRANRTQRFIQNKCNEVEHKINFYREFHEKISALQKEFDH--IQHNELL-L
NP----EVNPDVKEELYHLKNQITGIQSSILQVLKLKEVFDCIELNWDWTQLD---QIQT
QVLEKERELEEKIKQLNTFVAEYDKYQASLAKLKALDLQIKKRAEPVLTMPNTPP-ESSL
LNAQVLNQRI------------------DFDDLFKEREIQQLKLYAEEHNKLRQVLQQKM
ALQSQLKEMDEKDFKDKLENSLHVLNQIKSQLQQPLLINLQIEYIQNEKDNCEVFQEKVQ
AEMDSIKAVTVIEKQSE-ENSS-EASVVEAKLNDIEDLYMQLNASIDSRTSVLNDAYENM
TRYNEAVSRAMGIISDLETIIVSHRVDLDNPKESVEVPRQK-QEELKSTIAGIQDLTENL
GTVSSLEAKRQLECTLQDLVSKNSALREAAKVKEAEVE--RCL------DNYKRYRNINE
KICTNLSQMETILGQSMCPLPVSYKEALERLEQSKALVSNLMSAKEELLKQRQVLRHLRA
MCTDSDSLCLLRSTSALWERWLSLLEAAKEWEMWCEELKQEWKFVHEEIEREVIILDNLQ
EEVPEISKAKEAASTEELLGLLDCLRQYEENVEQQQLLLALLLQRIKNIQSTPESLGAVE
S-VPASQEIMSMQERCHKLLQKAQKNKELMQNEIQERHSFTKEITTLKNLFQQTTISFQN
MELQDCPEKAEQLEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECRNAL
EDVDEKISNEVLKSSPSYTTSRKIDEINNGLRNVEKMLQQKSKNIEKAQEIQKKMWDELD
LWHSKLNELDSEVQDIVEQDPGQAQEWMDKLMIPFQQYQQVSQRAESRTSQLNKATIKME
EYHDLLKSTEAWIENTSRLLADPADYDSSKTLSHHASTLQMA-LEDSEQKHTLLHSVFTD
LEDLSAIFETDDLAQ-SIQELSHQVAALQQRIIESLPQIQRMADDVVAIETEVKSMEKKV
SKIKAILL-SKEIFDFSPEEHLKHGE----------------------------------
-VILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFERTNRLLQDIKLLENVTQEQNEL
LKI-AIKQTNECNEEMEKLKQILNNYPAEFSHEHMSTDQAANLSQVQG-EIEGMEKQILS
LNQKKEDLVVDLKAAILNLHQHLQQKQQELE--QEVLSVGAS-EENTGAEK-DASEWKL-
--NRTSSMSFLPALEEEAEESSLKSESGDKKAEPSSGF--LSLLWKHDKDV-EEDRA-SS
SSGTIIQE----AAGKISTCDSSMAQVLEPDLLNTE---RGPEFSLSPNQTPEGATPPIK
AAATGLSDEQG-AFEATV--EKVRPEPAEVLHVCKNQVAELELWLHQANVAFEPETLDAD
MQQVVEQQLVGCQAMLTEIEQKVASLLENCKDQGLGDSGATQQEAEALSLKLKTVKCNLE
KVQMMLQEKYSEDQ--YVLSLKKY--T--YVLDIGEINSLDELKNVLQHSTTLKRQKDFQ
QQQ--VLELKPMEQKDLIKFIEFN-ANKTWPQYCQHDKDT-TQTSSA---------RSSK
TSSPQNDAPDLILSTQGQ-SGDKWQY-----L-HHELSSKIRLPLS-QLVQPQVTTNMSI
LPSVTVYNFRYPTTEELKTYTTQLEDLRQEANNLQAQENTSEETYTNLDKKLFELFQTLL
QCLGSVEDMLQTPGLFRGDVGTQQVHY----ETLALELKKLYLAMSDKKNDLSKAMTWPG
KNASQFLDCFDNLQVYLEHTQATAASRSKALKAGLDYTHSYQNEIKRLYDQLVKNKTSLQ
QSLNEISGQTIDEQLQKVDAYTVELQNSESRVAKLRDEGERLHLPYVLLQEVYKLEDVLD
SMWGLLRARYTELSCPFITESQQDALLQGMVELVNIGKEKLAHDHLQQTKSKVALQAQIQ
NHKLFFQKLVADMLLIQTYSNKMLPSLMQKKETFGAEQVKEVKLLEEKSHQYGIKLQSLL
QKWEEFDENYASLEKDLEILMSTLPSVSLVEETEERLVERISYYQQIKRNLDEKHARLYQ
TLNEGKQLVASVNCPELEGQIAKLEEQWLSLNKKIDHELHRLQTLLKHLL------SYNR
DSDQLTKWLESSQQTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVLST
GNQLLHLKEADTATLRASLAQFEQKWTGLITQLPDIQEKLHQLQMEKLPSRKAIMEMIDW
MNNVEHQTEDEDSEHSLSSASQVKNLLQKYKEFRMEMDYKQWIVDFVNQSLLQLSTCDVE
SKRYERTEFAEHLGEMNRQWQQVHGALNGKIQHLEQLLESITENENKIQILNNWMEAQEE
RLKTLQKPENVISVQKTLLDCQDIENQLAMKSKALDELRQNYLTSES-GTVPLLEDTASK
IDELFQKRNNVMNQVNELKTSMQSVLQEWKIYDKLYDEVNMMTIRFWYCMEHSKPVV--L
SLEALRCQVQNLQTLQDEAESSEGSWKKLQEVIGKLKEYC-PSVAEIIQEKCQNTH--TR
WTQVNQ---DIADQLQRAQSLLQLWQACSSAHAEAAARLEPQETKWQQLANINTSGNNLA
EVLPPALQGAK-ELQCEVQKTKEAFLQNSTLLDRLPQ-PAEPNTHVLLSSQMHSLQRASY
LEKMLLVKTNEFEFVLSQFKDFGDRLESLKGLI-THEEENLDKLYRQEK--EGNPDLFLN
HVLALTAQSPDIEHLNEVSLKLPLSDVAMKTLQNVNRQWIRATATAL-ERCSELQGIGLN
-EK-FLHCYEKWVQLLQKIEETLKANMADSLPALLEQQKTYEMLEAEVSINQTIADSYVT
QCLQLLDTAEIEKRPEFVWKFTRLKGQWQSAAQGVRQRKSDIDELVRQWRSFT-TSEG-D
LLRFLADTSHLLSAVKSQDCHSLHQTRSLIHELKNKEIHFQRWQTTYALTLEAGEKLLN-
-TANLETKESVNKRISQLQDNWKDTKLQLGEMIKRFQSTA-ETWDQCEKKIKELKNRLHV
LKAQSKDPLPELHEELHREKELIKELEKSLANWTQNLKELHTMKTDLTQHILVDDVMVLK
EQIEHLHRQWEDLCLRVAIRKQEIEDRLNSWIVFNEKNKELCAWLVQMENKVLQTADISI
EEMIEKLQ-----------------------------------------------KDCME
EINLFSENK-LQLKQMGDRLIKASNKTRAAEIDDKLNKINDRWQHLFDVIGSR-------
---------------------------------------VKKLKETFAFIQQLDKNMSNL
RTWLARIESELSKPVVYDVCDDQEIQKRLAEQQ-DLQRDIEQHSAGVESVFNICDVLLHD
SDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIE ETWR LWQKFLDDYSRFEDWLK
AAERTAACPNSSEVLYTVAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTAS
KLKQMVHEGNQRWDNLQKRVTAILRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH
FSESDADDKMRQLN-GFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRY
CQEVFGRVSRFHRRLTSHAPGLEDEKEASENETDVED--PREIQDDSWRKRGASEE----
PSSPQSLC----QLVPPAL----GPERSGCE--TPVSVDSIPLEWDHTGDVGG-SSSH--
-----EED----EEGPYYSAL-----------------------SGKSISEGPS------
------------WHVPDSPSCPKRRYKQMGGDRNVQPIPSDSSTPYKPAYVKLLLSPGT-
EGGKED---PGVLTGSAQQ-ED-EDLAALTG-QQ--SGAFDRWELIQAQELHNKLRKKQN
L---QKLNSDISNITPWLEKTGA-ELETLKLAEPPSDMQEMELQVKKLKEILKAFDTYKA
LVVSVNVNSKEFLQSESAESKE--LQGRVGQLTLRWNTALGAVESWREGLRRSLMQCQDF
HQLSQSLLLWLASAESRRQKAH-V-TDPEADPQALLACQEELVQLEKELVERQPQVNSLQ
EISSTLLIKGHGEDYIEAEEKVHVIEKKLKQLLEQVSQDLVSLQRSQNPDS-PLPS----
--VD--EVD-HGE--PLAASAPAPQAK-FEA----EKTTKEKNKTA-------SRVPGPA
APE-SSKPQRSFLSRVFRAALPLQLLLLLLLFLACLLPSSEEDYSCTQANNFARSFYPML
RYTNGPPPT---------------------------------------------------
-

Query Results

"ENSGT00900000140842_2"

ENSGT00900000140842_2