Query Results 

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--------------------------------PRLE-VEEAN-GKELADVLIDRSPQILD
RG-VVNS----SE-KMNLTDLSKMAK-GQIPGSAQ-GQ------GKMAEL---EDTDT--
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-----------------------------------------EDDLDVEMSGKKEECRNI-
---------TEI----------------LPLL--RKNKFQLVGSDNFLASVI--------
-----------------------------------------------QRSQKFIPFLQPR
IA--PQPIA----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVVLYGPAGVGKSTLAKQV-----FLDWA--E---------NNLNQ
---------MFNY-VFYLRCKELNHVG-------ACSFAE-LIFK-DW-----PE-WLGC
AAEVFG-QA----QKILFIIDGFEE-LRVPAG------ALIH-D-----ICGNWERE-MP
-VPVLLGSLLKRKMLPKASLLVT-TRPEALRELRLLV-E-----QPL--FIEMEGLLEPD
RRAYF----------------L--RQ-FAD---------QDQALRALDLMKG-NV-----
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-------------------------------VQ-KLFSKEERV-RNPSLTQVGYFL----
----FGLSNEKRVQELESTFGCR---------------M--SLQ-IRE-ELLKYRANLDE
NK------------------------------------PFSRTDMKELLYCLYESQD-EG
LMRDAMVP---------------------F-------------------TEVSLHWMNTF
EV---MYS--S----FCLK-HCQN-LQK-LSLQ----------------IARG----IFL
-END-PVS----RE--------------------DAQLE-----------SWSRCD-HRS
LCVWMDFC-SVVSSNKNLRVLDMTQSFLSDS---------SVRILC--DHITR-F-----
SC--H-LQKVV--I-RNVTPD--SA----YR-DFCLAF----------------VGKKTL
THLT-LEGH-VQWDDMLLLLLGEVLKHVKCS----LQYL--------RLG---------F
H------S----------------------------------------------------
---------VT---TE-RWT---NLTLALKV-NQSLMCLDLSDNELLD-ESAKLLYTS--
LKG-PKCLLQRL------------------------------------------------
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---------------------------------------------------HWRCYRER-
--------MKAD----------------ILRM--WARAPWPEDHIHLLTP----------
-----------------------------------------------YEHQELERVLCP-
RG--ADMRP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

LTVVLEGSAGVGKTTVAAKL-----ALHWA--E---------GMLLH
R--------CFSF-VSYISCHQVNEMG-------DACLAD-LLSL-HW-----SPDPRFL
MQKFLS-HP----QRLLFIVDGIEE-LRCPVEAE--S------P-----HLADWFQR-LP
-ATQVLLSLLRRKALPTATLLVT-SRAQRRPALYRLL-R-----RPS--FVTLRGFSEDD
QEEYF----------------L--RF-FGD---------QDTGKAIMQWLRA-TGTWLPT
CCAPLMCRVVGTYLKRQRA-TN-SF-Q--LG-AQSPTALYAGFFSSLVSA-E-AGLQGVG
------------AHEQWGALCRLA---ARGM-WQ-ST----GAFKAD-------------
--DGSRA------LAAPFIQALLRLNILQAVAS-CE-DCVAFIHPSFQAFFGALFYVLR-
GTPGC--------------LGGL--TK-PQELH-M-LQLSLAD-RATHWEQTAIFF----
----FGLLHRDVARELEGAP------------------P--APATATD-QVLEWAEG-LD
GA-----------------------------------A-SL--WGMLLFQCLHEAQE-AS
MVKQVLSH---------------------L-------------------REAHVDVCGNR
QL---QDA--A----FCL-RDCRN-LQK-LRLS----------------LS---------
----GPS---------------------------------RG----SSLKTPGKMA-SSK
IRQWQDIC-SVFSYG-NVHELDLSNSTLNTL---------TMKKLC--RELRN-P-----
RC--K-LRQLT--C-RSVEP---RR---VLQ-ELPVVL----------------HGNS

PF00560 // ENSGT00900000140813_0_Domain_6 (1619, 1645)

RL
THLD-LSAN-DL-GV-TVPLIFKTLRHPACQ----LRSL--------CLE---------K
C------N----------------------------------------------------
---------LS---SD-TYR---GLASLLIS-AQKTTHLCLGFNPLQD-NGVQLLCAS--
LVL-PDCALQRL-E----------------------------------------------
------------------------LWFCQLG-----------------------------
----------------------------APSGQYLSR-----------------------
--------------------------------ALLQNRALTC---LN-LRRNR-LGD---
-------EGVEDLCVAL----RGPHC----------------------------------
--------------------------RLQ-RLD---------------------------
-------------------------------LSACSFSVPGCGALAAA-LRDNRSLQVLD
V-GENEFGDDGME-ALSQALGPA--P-A----L---------------------------
-----------------------TTLGL--QKC-----QLTAASNEHL------------
-------GHLL-RGSKSLVSLNLLGNDLQLQGLSM-LWKAVK-SS-QC-PLRVLG-----
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----MSVD--M----QCVDIQCEE-LSD-ARWA----------------EL---------
----LPLL-------------------------------QRCQAV------RLDDC-GLT
EAQCKDVS-SALQA

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELNLRNNELGDA---------GVHRVL--QALQS-S-----
SC--K-IQKLS--F-QSCYLT--VA---GCG-VLSGTL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LPTL
QELH-LSDN-PMGDA-GLQLLCEGLLDPQCR----LEKL--------QLE---------Y
C------S----------------------------------------------------
---------LS---SA-GCE---HLASVLRA-KPDFKELTVSNNDIDE-AGVRTLCQG--
LKD-SPCQLETL-K----------------------------------------------
------------------------LEKCGAT-----------------------------
----------------------------SDNCRDLCS-----------------------
--------------------------------ILASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLRE---LA-LGNNK-LGD---
-------VGIAELCPGL----LHPSS----------------------------------
--------------------------RLR-TLW---------------------------
-------------------------------IWECGLTAKSCVDLCRV-LRAKD

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-AGNNLGDEGAR-LLCESLLES--GCQ----L---------------------------
-----------------------ESLWV--KSC-----SLTAACCSHF------------
-------SSVL-AQ

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NKFLLELQISENRLGDAGVQE-LCQGLG-QP-GS-VLRSLW--LG-
--D-CDVSDSSCS--------------------SLAATLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NHSL-RELDLSNNCLGDEG
ILALMG--------SVRQPACL--LE--Q-------------------------------
---LVLYDI-YWSLEMDNQ------LQ----------ALE-KEKPSLRIIS---------
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---------------MNN---------------------------QKKRKHMGLA-----
--------CTWY------------------------------------------LLSG--
-----------------------------------------E------------------
-------------------------------------------------NDYPDIFRKH-
--------LKEK----------------YLKI-GADKCYHHGK--------------HIE
SRLLLVKDHGISEEAPYGIP-------------------------QQDRFIDMEHIFDSN
EE--GSSSS----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 929)

RTVVLQGCAGTGKTAVVHKF-----MFDWA--A---------GVVTP
G--------RFDY-LIYINCREISPIA-------NLSAAD-LITN-TF-----QD-INRP
ILDIFLIYP----EKILFILDGFPE-LQDPVRDQ------EE-D-----LSVHPQER-NS
---------VRKKLFPESSLLIT-AWPTAMKKLHSLL-K-----QPI--QVEILWFTDTE
KRAYL----------------L--SQ-FSG---------ANTAMKVFYGLRE-NEDLDIM
SSLPIVSWMICKVLQPKGDGDG-TL-L--RS-LQTMTDVYLFYFSKCLKTLTDIS-AW--
-----------EGQSCLWGLCSLA---VEGL-QN-RQ----VLFAVS-------------
--DLRRHEIGVCDTNCTFLSR-----FLKKAAG-TV-NVYTFLHFSFQEFLTAVFYALK-
NDNSW---------------------MCSYQVGKMWQEIFQQF-GK--------------
----------GKGKTVETTFGRK---------------V--SPG-LRE-ELLKWTEGEIK
DK-----------------------------------YSRWQIEPMDLFHCL--------
----VIDD---------------------L-------------------QSLILLQPTYT
KM-DILAM--S----FCIK-SSHNHRS----------------V-----SLKCQHLLGF-
-EEEERAS----------------------AFMP--------------------------
---------PVPTNTF---------NDIPIF---------F---------IFFL------
KC--L-FSPHRL---IFCHFT------ASCGRD---------------LSSVFET-NRYL
TDLE-FVKS-TLEDS-GMKLLCEGLKHPNSV----LQTLR--------LYRCLI-SSA-S
CG------------AL----AAVLSTSKWLTELEFSETKLEASALKLFCEGLKHPNCK-L
QKLKLCANLLPEGSET-VCK---YLASVLIC-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NPHLTELDLSENPLGD-VGVKYL

ENSGT00900000140813_0_Linker_8_10 (1796, 1805)

CVS--
LRH-

PF13516 // ENSGT00900000140813_0_Domain_10 (1805, 1955)

SNCKVEKL-D----------------------------------------------
------------------------LSTCHLT-----------------------------
----------------------------DASCVELSS-----------------------
--------------------------------FLQGSQTLKE---LF-MFANV-LGD---
-------TGVQHLCKGL----QHTKGVIENL-----------------------------
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------------------------------GLSECSLSVACCKPFAQV-LSSSRSLTRLL
L-INNKIEDMGLK-LLCEGLKQP--DCQ----L---------------------------
-----------------------KDLAL--WTC-----HLTGACCQDL------------
-------CNVP-YTNEHR

PF13516 // ENSGT00900000140813_0_Domain_15 (2359, 2378)

RDLDLSDNALGHEGMQV-LCEGLK-RP-CC-KLQTLW--LA-
--G-CHLTDACCG--------------------ALASVLNR

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NENL-TLLDLSGNDLKAFG
VQVLCD--------ALIHPIFL--MQDFF-------------------------------
--PFSSIDTDHLHEDTFRK------ME----------VLK-MSKPVIIW-----------
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---------------MSLDIQCEQ-LSD-ARWT----------------EL---------
----LPLI-------------------------------QQYQVV------RLDDC-GLT
EVRCKDIS-SAIQ

PF13516 // ENSGT00900000140813_0_Domain_4 (1514, 1542)

SNPTLTELSLCTNELGDP---------GVCLVL--QGLQN-P-----
TC--K-IQKLS--L-QNCSLT--EA---GCR-VLPDVL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LPTL
RELH-LSDN-PLGDA-GLKLLCEGLLDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LT---AT-SCE---PLASVFRV-KPNFKEIVLSNNDLHE-AGVQMLCQG--
LKD-SACQLESL-K----------------------------------------------
------------------------LENCGIT-----------------------------
----------------------------SANCKDLCD-----------------------
--------------------------------VVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLQQ---LD-LGSNK-LGN---
-------AGIAALCSGL----LLPSC----------------------------------
--------------------------RIR-TLW---------------------------
-------------------------------LWECDITAEGCKDLCRV-LRT

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

KQSLKELS
L-AGNELRDEGAQ-LLCESLLEP--GCQ----L---------------------------
-----------------------ESLWI--KTC-----SLTAACCSHI------------
-------CSVL-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNRSLLELQMSSNPLGDLGVLE-L

ENSGT00900000140813_0_Linker_15_16 (2378, 2391)

CKALG-QP-DT-V

PF13516 // ENSGT00900000140813_0_Domain_16 (2391, 2436)

LRVLW--LG-
--D-CDVTDNGCS--------------------SL

ENSGT00900000140813_0_Linker_16_17 (2436, 2441)

ATVLL

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2464)

HNRSL-RELDLSNNCMGDSG
VLRLVE--------SVRQPSCA--LQ--Q-------------------------------
---LVLYDI-YWTEEVEDQ------LR----------ALE-EERPSLRVIS---------
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-----------MA---ASFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 322)

-LMWYLEELK--K---EEFRKFKEHLKQ------
---------L--TSHLE--------L--KPI-PWAE-VKKAS-REELANLLIKHYEEQQA
WNVTLRI----FQ-KMDRKDLCVKVT-RER------------TG--------------YT
K---------------------------------------------------TYQD----
------------------------------------------------------------
----------------------------------------------------------H-
--------AKKK----------------FSHL--WSSKSVTDIHRY--------------
---------------------------------F-------HQEVKQEECDHLDRLFASK
ET--GKQ-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RTVVIQGAQGIGKTTLLMKL-----MWAWS--D---------SRIYR
D--------RFLY-AFYFCCREMRELP-------VVSLAD-LICR-EW-----PDP-AAP
VTEIMS-QP----ERLLFIIDSFEQ-LEADVNQP------DS-D-----LCGDWKER-RP
-VQVVLSSLLRKKMLPEASLLVA-VKPTCPKELRDRV-A-----ISE--IYEPRGFDESD
RLVYF----------------C--CF-FQD---------PKRAMEAFSLVRE-SQQLFAL
CQIPLLCWLLCTALKQEMQKGK-DL-A--VT-CQSTTSVYASFIFNLFTPED-ATGPTE-
-----------QSQCQLKGLCALA---AEGM-WT-DT----FEFGDE-------------
--DLRRHGIADA-DIPALLGT----KVLLKFGE-RA-SSYTFIHMCIQEFCAAMFYLLK-
SHLDH-----------------P--HPAVRSVE-ELLVNNFKKARRPHWIFLGCFL----
----IGLLNKKEQEKLNGFFGFQ---------------L--SQE-IKQ-QFEQCLKSLGE
Q-G----------------------------------DLQGQVDALAIFYCLFEMQE-PA
FVRQAVNL---------------------L-------------------QEGSFHIVDNS
DL---VVS--A----YCLK-YCSS-LRK-LSFS----------------IQN-----VFK
-KED-THS-----------S-----------------------------------VSDYS
LICWHHIC-SVFTTNGYLREVQVQDSTLSEP---------AFVTWC--NQLRHP------
SC--R-LQKLGINN---------VSF-SGKSSHLFEVL----------------FHQPDL
KYLS-LTLT-KLSRD-DVKSLCDALNSPAGN----IEEL--------AL-----------
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-------------------------VSCELS-----------------------------
----------------------------PVDCEVFAF-----------------------
--------------------------------VLT

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

KNKKLKY---LN-VSCNH-ID----
-------EGVRHLCEAL----CHPDTVLTYL-----------------------------
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------------------------------MLAYCHLSEQCWEYFSEM-LLR

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NSSLRHVD
L-GANILKDEGLK-TLCKALKHP--DCR----L---------------------------
-----------------------DSLCL--VKC-----FITAAGCEDL------------
-------ALVL-I

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

SNQNLKNLEIGCNEIGDVGVKL-LCAALK-HP-DC-HVEVLG--LE-
--D-CALTGACCK--------------------DLASVLTSSKTL-QQLNLTLNALDHGG
VVVLCQ--------ALRHPECA--LR--V-------------------------------
---LGLKKA-DFGEETQAL------LM----------AEE-ERNPKLTIVDH-LDTTTWA
EI----------------------------------------------------------
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------------CLP----STHDSLCR

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LSAYLEELE--A---VELKKFKLYLGA------
---------L---PEAE--------G--GRI-PWGK-LEPAG-PLDTAQLLVAHCGPAAA
WPLALGL----FQ-RIHRRDLW

ENSGT00900000140813_0_Linker_0_1 (323, 536)

ERGQ-REDPVRDT----P--PD--------GSSSL---
------------------------------------------------------ES----
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---QS-VCCL-------------------------------EVFPGTPRKDPRET

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 658)

YKDY-
--------VRRK----------------FRLM--QDRNARLGECV---------NLSRRY
TRLLLVKEHSTPMWAQQKLL------DTGWGQARAVG--------HQASLIQMETLFEPD
EE--RPEPP----RTVVLQGAAGMGKSMLAHKV-----MLDWA--D---------GKLFQ
G--------RFDY-LFYINCREMNQSTS------EQSARD-LISS-CW-----PE-PSVP
LQELVR-VP----ERLLFIIDGFDE-LKPSFHHP------QG-P-----WCLCWEEK-RP
-TELLLGSLLGKKLLPELSMIIT-TRPTALDKLQRLL-E-----HPR--HVEILGFSEAE
RREYC----------------Y--KY-FHN---------AEQAAQVFSFMRD-NEPLFTL
CFVPMVCWVVCTCLKQQLEDGG-LL-R--QT-SRTTTAVYLLYLLSLMQPKPGS-PTL--
-----------HPPANQRALCSLA---ADGV-WN-QK----ILFEEQ-------------
--DLRKHGLDGA-DVSSFLNM----NIFQKDIN-CE-KFYSFIHLSFQEFFAAMYYILG-
-----------------------------QSVT-RLLAEYGFS-GRSFLGLTVRFL----
----FGLLNEETRSYLEKSLCWE---------------V--SPH-VKL-ELLAWIQSKAR
SE-----------------------------------GSTLQQGSLELFSCLYEIQE-EE
FIQQALSH---------------------F-------------------RVLVVGNIT-T
KM-EHVIA--S----LCVK-NCRN-ALT-VRLH----------------GA------AYS
-PEDPASG--S------------------------------------------------G
L-------------------------MA------------------------Q-------
SL--E--------PETNVLPD-------AYSKQLAAAL----------------S

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1642)

TNPHL
RELL-LDHN-ALGSR-GVRLLCEGLRHPSCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------CVA---PS-ACR---DLAAALMA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NQNLRRMDLSGNGLGL-PGVKMLCQG--
LRH-PRCRLQAIQ-----------------------------------------------
------------------------LRKCELE-----------------------------
----------------------------AGACQEIAS-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

TNQHLVE---LD-LAGNS-LED---
-------LGLRLLCQGL----RHPVC----------------------------------
--------------------------GLR-ILW---------------------------
-------------------------------LKICDLTAAACEDLTSI-LSV

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NCSLRELD
L-SLNDLGDPGVL-LLCEGLRHP--QCR----L---------------------------
-----------------------QTLRL--GIC-----RLGSAACEGL------------
-------GAVL-QV

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2373)

NPHLRELDLSFNDLGDRGMWP-LCEGLG-HP-TC-RLQKLW--LD-
--S-CGLTAKACE--------------------HLASALGV

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SQTL-TELYLTNNALGDTG
VRLLCK--------GLSHPGCK--LR--V-------------------------------
---LWLFGM-DLNKMTHRR------LD----------VLR-GTRPHLDIGC---------
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---------MQK----------------QSLV--WKNTFWQGDTDSFHDDVI--------
-----------------------------------------------RRNQRFIPFLNAR
TP--GKLTP----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLHGPAGVGKTTLAKKC-----MLDWS--D---------CNLSP
---------TVRY-AFYLSCKELSRMR-------PCSFAE-LISK-DW-----PE-LQDD
IPSILA-QA----QRILFVVDGLDE-LKVPPG------ALIQ-D-----ICGDWKQQ-KP
-VPVLLGSLLKRKMLPKATLLVT-TRPRALRDLQLLV-Q-----QPI--YIRVEGFLEED
RRAYF----------------L--RH-FGE---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMENGE-DP-A--PT-CLTSTELFLRFLCSQFPQG-------AQ
------------LRGALRALSLLA---AQSL-WA-QM----SVLHRE-------------
--DLESAGVQES-DLRPFLDR----DILHQDRV-SK-SCYSFIHLSFQQFLTALFYALE-
KE--E---EE--------DRDGH--AWDIGDVQ-KLLSEEERL-KNPDLIQVGHFL----
----FGLANEKRVKELEATFGCR---------------M--SPE-IKQ-ELLRCKANLHA
NK-----------------------------------P-LSMTDLKEVLCCLYESQE-EE
LAKVVVAP---------------------L-------------------KKISIKLANTS
EI---MHC--S----FSLK-QCPD-LEK-VSLQ----------------VAKG----VFL
-ENY-VDI----EP--------------------DIEFERC-TYV--TLPSWAQQD-LRS
LRLWTDFC-SLFSSNSNLKFLEVKQSFLSDS---------SVRILC--DHITR-S-----
TC--H-LQKVE--I-KNVTPD--TA----YR-DFCLAF----------------IGKKTL
THLT-LEGH-IEWERTMLLLLCDLVRNHKCN----LQYL--------RLG---------G
H------C----------------------------------------------------
---------AT---SE-QWA---DFSYVLKA-NQSLRHLHLSASVLLD-EGAKLLYKT--
MTH-PKHFLQML-S----------------------------------------------
------------------------LENCRLT-----------------------------
----------------------------EASCKDLAA-----------------------
--------------------------------VLVVSQQLTH---LC-LAKNP-IGD---
-------TGVKFLCEGL----SYPEC----------------------------------
--------------------------KLQ-ALV---------------------------
-------------------------------LQQCSITKRGCRYLSEA-LQEACSLTNLD
L-SLNQIA-RGLW-ILCQALENP--NCN----L---------------------------
-----------------------KHLRL--WSC-----SLMPFYCQHL------------
-------GSAL-ISNQKLETLDLGQNHLWKSGIIQ-LFRVLR-QR-T-------------
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----------------------------------------MA------------------
----------SPAGISWHDGA

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 326)

RDQ---LLSHLRGLD--P---WQLEDFKLALQCPELL--
--------------PEG--------A--RRI-PWAD-LRAAG-PADLLCLLEERFPGRRT
WEAALRV----FE-DLRLSSLCERMR-AELHEEVQ-SQNTQDTYLT------EMSLFICC
----IQRVPVPGFL-----------------------L----------PQEDW-------
---------LCYVESF-------SCNKMS----------QVCRLQDPNQ-----------
------EEPE-------------------------------TLEET----AHRRRYRER-
--------LRTR----------------ILAL--WDRTPWPEDHIYLRHVTQ--------
----------------------------------------------R-EHAELRGLLRPR
G---AGAPP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 929)

TMLLEGAAGVGKTTLATKL-----VLHWA--E---------GVLFR
G--------RFSY-VFYISGHWLAKLG-------DISFAG-LLAL-DW-----PD-SQVP
VEEFRA-HP----ERLLFVIDGAEE-VTLGSK------GSAS-R-----PGADWYQE-LP
-AASILVRLLKKELVPEATLLVT-AGPPGGHALRGLL-L-----RPC--RVGIPGFTEGD
RREYL----------------R--RF-LGD---------PDVAEEAWRRMQG-SETLVRL
CAAPLACWAVCAGLKRQLAGSP-A---PAPG-APTPTGLYAQLFCSLLAGAE-PGLRTGS
------------SAGQWRAFCSLA---AEGL-WL-AA----FTFAGD-------------
--ALERWRLEAP-FIDGLLRL----QILRRVSD-CE-HCVTFAHRSFQEFFGALFYVLW-
GAQGS--------------L-GG--VPRHQEMR-RWLNHAFAD-ANPYWRQMVRFF----
----FGLLGTDLARQLEEAVGCR---------------M--SPG-VAD-EVLDWAEELER
CG-----------------------------------AVSGRFDFLWLFQCLHETQD-EN
LARRVLNR---------------------L-------------------PVADLDIQGCE
HL---RVS--S----FCLK-HCQK-LRK-LRLS----------------VSH-----RVL
-EKKRT----------------------------------------SGL--GTPDA-DFR
MHQWEDIC-S-VFCSGNLSQLDLSNSKLSTA---------SMMRLC--LKLGN-P-----
QC--R-LQKLA--W-KSMAPV--EG---L-R-KLGLLL----------------RGDRHL
THLD-LSSN-SLDAA-VSRGVFRMLGHSACG----LKYL--------WLE---------K
G------N----------------------------------------------------
---------LS---AA-ACE---DL-----------------------------------
------------------------------------------------------------
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-----------------------------------AS-----------------------
--------------------------------LLTSTPRLTR---LC-LGLNP-LGD---
-------EGVQLLCGSL----TRPEC----------------------------------
--------------------------VLQ-RLE---------------------------
-------------------------------LWCCRLSTPSCRHLSDA-LLRSRSLTHLN
L-RRNSLGDGGVK-LLSSALGRA--DCA----L---------------------------
-----------------------QSLNL--SHC-----SLTVAGCREL------------
-------AHAL-KHNGHLKILDVGNNDIQDEGVKE-LCSVLK-SP-SC-VLQTLG--LE-
--K-CSLTAACCR--------------------PLSSVLGSSKSL-ENLNLLGNNLGPDG
VSRLWM--------PLRKPTCK--LR--K-------------------------------
---LG-------------------------------------------------------
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----------------------------------------------------------FF
---HAEEQ------------------------------------DSEADKNGLHSYKAH-
--------VIAK----------------FDTH--VEVH-Y--------------------
--------------------------------------------DSPEM-QVLLKAFKSY
Q---KAFWP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVILHGKPGVGKSSLARSI-----ILGWA--Q---------GKLYQ
D--------M-SY-AFFFSVREIKWTE-------KSSLAE-LISE-EW-----PY-LQAS
VAKIMS-KP----ERLLFVLDGFDD-LDLALLQD------DM-R-----PSGDWEDE-QP
-IYILMYSLLMKVLLPQSCLIIT-TRDTDLEKLKSLA-V-----SPL--YILVGGLSATR
RTQLL----------------L--EN-ISD---------DQRRKHVVRTVIE-NDQIFDQ
CQVPSICSLVCEALKLQEKLGE-RC-A--PV-CWTLTSLYATLVFHQLTPRE-PFQSCLS
----------HREQVALMGLCGMA---AEGV-WN-MR----SVFYDD-------------
--DLQNYGLEEA-AISALFHM----NVLLRVDD-STEQYYIFFHLSLQDFCAALYYLLK-
GLK-K--------------WNQY--CLFVENPKRNIMTLKRTN-FNTHLLEMKRFL----
----FGLMNKDTMRTLEALLGCP---------------V--SP-AVKQ-RLQHWVFEVGQ
QVS----------------------------------ATG-PEDVLDAFYYLFESQD-KE
FVCWALNS---------------------F-------------------QEVWLQVNQKM
DL---MVS--S----YCLQ-HCQN-LKT-LRVD----------------VRD-----IFL
-VDKNAEL----CP--------------------VA-----------LP--QAQGK-SLI
MELWEDFC-SVLSMHPKLNKLDLGSSVLNEW---------AMKILC--LKLRN-P-----
AC--N-IQNLM--L-KDAEI---AA---GLQ-YLWMTL----------------V

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1641)

SNRNL
KYLN-LGNN-NLKDD-DIKLVCEALRHPNCS----LETL--------RLD---------S
C------E----------------------------------------------------
---------LT---SD-SYS---MISELLLS-STSLKSLSLARNGVTE-KSMGQLCGA--
LSS-SRCILQKL-I----------------------------------------------
------------------------LDSCELS-----------------------------
----------------------------LVSCHGLVS-----------------------
--------------------------------ALSGNMTLTH---LC-LSNNS-LRT---
-------EEVRLLCQFM----KGPRC----------------------------------
--------------------------ALQ-RLL---------------------------
-------------------------------LNQCDLKRDACGFLALM-LI

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

NNRTLTHLS
L-TKNPVVDDGVK-FLCEAIKEP--TLD----RGCG------------------------
---------------------FPVSRRL--VEC-----WLTGDCCENL------------
-------ASMI-TM

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NQHLKSLDLGYNNLGDNGVIA-LCKGLK-QN-NS-SLRRLG--LE-
--A-CGLTFESCE--------------------ALSSTLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2465)

SNQCL-TSLNLVKNSFSTPG
MLKLCY--------AFRHFTSN--LR--I-------------------------------
---IGLWKQ-QHHAEVRRQ------LE----------EIQ-LTRPHTVITGDWYSLE---
--E---------------------------------------------------------
--------------------------------------------------DDRNWWKN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSLDIQCEQ-LSD-ARWA----------------EL---------
----LPLL-------------------------------QQCQVV------RLDDC-GLT
EARCSDIS-SALRVNPALTELSLCGNELGDA---------GMHCVV--QGLQS-P-----
SC--K-IQKLS--L-QNCCLT--GA---GCG-VLSSTL----------------RYLPTL
QELH-LSDN-LLGDA-GLQLLCEGLLDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LS---AA-SCE---SLASVLRA-KPDFKELTVSNNDINE-AGVRVLCQG--
LKD-SPCQLEAL-K----------------------------------------------
------------------------LESCGIT-----------------------------
----------------------------SNNCRDLCS-----------------------
--------------------------------IVASKASLRE---LA-LGSNK-LGD---
-------VGIAELCPGL----LHPSS----------------------------------
--------------------------SLR-TLW---------------------------
-------------------------------IWECGITAKGCADLCGV-LRTKESLKELS
L-AGNELGDEGAR-LLCETLLEP--GCQ----L---------------------------
-----------------------ESLWV--KSC-----SFTAACCSHF------------
-------SSVL-TQNKFLLELQISNNRLGDAGVQE-LCKGLG-QP-GS-VLRVLW--LG-
--D-CDMSDRSCS--------------------SLAATLLANQ

PF00560 // ENSGT00900000140813_0_Domain_17 (2444, 2458)

SL-RELDLSNNCLGDAG
VLQLVE--------SVRQPSCL--LE--Q-------------------------------
---LVLYDI-YWSEATEDR------LQ----------ALE-EEKPSLRVIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MDQPEAPCSSTGPR--LAVAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLAALEELS--Q---EQLKRFRHKLRD------
------------VGPDG-----------RSI-PWGR-LERAD-AVDLAEQLAQFYGPEPA
LEVARKT----LK-RADARDVAAQLQ-ERRLQR---------L---------GLG-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SG-TLLSVSEYKKKYREH-
--------VLQL----------------HARV--KERNARS------------VKITKRF
TKLLIAPESAAPE-E--AMGPAE-------EPEP--------GRARRSDTHTFNRLFRRD
E---EGRRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYQ
G--------QVDF-AFFMPCGELLERPG------TRSLAD-LILD-QC-----PD-RGAP
VPQMLA-QP----QRLLFILDGADE-LPALGGP--------EAA-----PCTDPFEA-AS
-GARVLGGLLSKALLPTALLLVT-TRAAAPGRLQGRL-C-----SPQ--CAEVRGFSDKD
KKKYF----------------Y--KY-FRD---------ERRAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLRQQLELGR-DL-S--RT-SKTTTSVYLLFITSVLSSAPVADGP---
-----------RLQGDLRNLCRLA---REGVLGR--R----AQFAEK-------------
--ELEQLELRGSKVQTLFLSKKELPGVLET-----E-VTYQFIDQSFQEFLAALSYLLE-
DGGVP-------------------R-TAAGGVG-TLLRGDAQP--HSHLVLTTRFL----
----FGLLSAERMRDIERHFGC-----------------MVSER-VKQ-EALRWVQGQGQ
GCPGVAPEVTEGAKGLEDTEEPEEE-----------EEGEEPNYPLELLYCLYETQE-DA
FVRQALCR---------------------F-------------------PELALQRVRFC
RM-DVAVL--S----YCVR-CCPA-GQA-LRLI------------------SC----RLV
------AA----------------------------------------QEK--K---KKS
----------------------------------------LGKR----------------
------LQAS---L--------------GGG------S----------------SSQGTT
KQ---LPAS-------LLHPLFQAMTDPLCH----LSSL--------TLS---------H
C-----------------------------------------------------------
--------KLP---DA-VCR---DLSEALRA-APALTELGLLHNRLS-EAGLRMLSEG--
-LAWPQCRVQTV------------------------------------------------
----------------------------RVQ-----------------------------
---------------LPDP---------QRGLQYL-------------------------
------------------------------VGMLRQSPALTT---LD-LSGC-QLPAPMV
--T--------YLCAVL----QHQGCGLQTLSL--ASVELSEQ-----------------
----------SLQELQAVKRAKP-------DLV----------------------I--TH
PALD-------------------GHPQPP-KELISTF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------M-----GESE--------------------------------EH---
----RTLGNTAHFGS----S----------------------------------------
--------------SK--------TT--PAS-PKRT-S---------DKVSVAQNEEQPD
WALGLCS----LE-KTNIS-LCTSDK-EVPYLTAGHDF----SFHS---SPSIPNMASPS
WPTSTAVLRFLGPDSL-----ENPLDSLERRIFTGLPDMSGHRL-RENHPSLCYQ--A--
---------LPSSPD-HTSPSQASPNPPLATAVLGSWKPPLHTDPEPSNRVLGTEY----
------T--------------------------------------MDKTTRNYCTETEK-
--------RYQD----------------QKTEKSW-------KNE---------VLCQKF
TQLLLLQKCHLRVPEL---V------VRESCHHDT--------VQEQGHLIEIQGLFGLG
PG--AQEEP----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

IVILYGAAGIGKSTLARQV-----KVAWE--Q---------GQLYR
D--------HFQH-VFYFSCRELARCK-------VMSVAE-LIEK-DW-----SD-SAAN
IGQILS-RP----EHLLFILDGVDE-PEWVLEDL------NS-E-----LCWHWSQP-LP
-VPALLGSLLRKTILSGASFLIT-TRTTALEKFIPSL-K-----EPH--WVEVLGFSESR
RKEYF----------------Y--KY-FTD---------ERQAIRAFSLVDS-NSALLTL
CLVPWVCRLVCTCLKQQMEQGD-EH-P--LT-SQTTTALCLHYLSQVLL--------TQ-
-----------DLRIPLKSLCSLA---AEGI-WQ-RK----TLFSAG-------------
--DLWMHGLESN-VIITFLKM----DVLQEH---PSTLSYSFTHRCFQEFFAAVSCVLG-
D------EEQ--------KSEHP--SIP-RVME-KLRKVYRSH--NLFGAPTMYFL----
----FGLLSEQGARGLESIFTCR---------------L--PAE-QRW-ELLQWVQEEA-
--------------------------------------LPWHPYSPDMLHCFYEIQD-KE
ILTQAMAH---------------------F-------------------QGTRMCVLTDL
EL---LVF--T----FCVK-FCSH-VKR-LQLN----------------ESEL-------
------QD----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------L------------
------GWRP--------------------------------------------------
-------------------PRVVLSTWKPLT-----------------------------
----------------------------NGSWKVLFS-----------------------
--------------------------------SLRDTGSLKE---LD-LSGNS-LSL---
-------SAMQNLCESL----KHPHCHLETLR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------L--VSC-----GLTA------------------
------------------------------------------------------------
---------SYCQ--------------------DLVSVLSA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SCSL-TELDLQQNDLGNNG
VQLL

ENSGT00900000140813_0_Linker_17_18 (2465, 2716)

CQ--------GLRLPTCQ--LT--L-------------------------------
---LWLDHT-LLSEEVKEE------LR----------VLK-EEKPQLLICS-RWKPRVMI
PSEGRDGGKMGNS-----------------TSSLKRQRPQ--------------------
---------------SEGGSPESPQ-MAPFLLPSPSPLGD-QHMKPLR-TEDDFHGPTGP
VPIEVTDK-ERNQYR

PF13553 // ENSGT00900000140813_0_Domain_18 (2716, 2997)

VHFPKAGSYHWP---NTGLDLAVRKAV-------TIEIKFCAWDQ
FLGISDLQHTWMVAGPLFDIKAEQGA-VAAVHLPHFVAIQEG--------VVDISLFQVA
HFKEEGMLLEKPTRVESHYIILENPSFSPMGVLLRMIPAARRFIPITTTTLLYHHLHLEE
V-TFHLYLIPSDCTIRKAIDDEEKKFKFVQIHKPPPMDPLYIGTRYNVSGS---------
KKLEIIPKELELCYRSPTEPQLFSEIYVANFGSKIQLQIRNKKDEILVWEALLKPG

ENSGT00900000140813_0_Linker_18_19 (2997, 3052)

DLRP
A-----------------V--------VH------PVSPGSHSPSNALALL

PF00619 // ENSGT00900000140813_0_Domain_19 (3052, 3134)

HFIDQHREQ
LVARVTSVDPVLDKLY-GKVLNEEQYESVRAEATKPGQMRKLFGFSQSWDRACKDKVYQA
LKEFHPHLVMELWEKWGGGTGGL-------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MVSST----QV

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 326)

NFN---LQALLEQLS--Q---DELSKFKSLLRT------
---------V--SLGNE--------V--QKI-PQKE-VDEAD-GKQLAEILISHCHSYWT
ELATIQV----FE-KMHRVDLSERAK-DELREAAL-KSFN----KNK------PLSLG--
------ITRKERQP---------------------------------IDVEEMLERFK-A
GTLECT---------------------------------ET--EEDATV-----------
-------LTE-------------------------------VFKVKGEKSDNENRYRLI-
--------LKTK----------------FREM--WQ--SWPGDSKEVHV-----------
---------------------------------------------MAERYRMLIPFSNPR
VL--PGPFS----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVVLHSPAGLGKTTLANKL-----MLDWT--E---------DNLIQ
---------KFKY-AFYLSCRELSRLG-------PCSFAE-MVFR-DW-----PE-LQDD
IPHILA-QA----QKILFVIDGFDE-LGAPPG------ALIQ-D-----ICGDWEQQ-KP
-VPVLLGSLLKRKMLPKANLLVT-TRPRALRDLRFLA-E-----QPI--YIRVEGFLESD
RRAYF----------------L--RH-FGE---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DP-A--PT-CLTSTELFLRFLCSQFPQ-------GAQ
------------LWGALRALSLLA---AQSL-WA-QM----SVLHGE-------------
--DLESAGVQES-DLRLFLDR----DILRQDRV-SK-GCYSFIHLSFQQFLTALFYALE-
KEEEE-------------DRDGH--AWDIGDVQ-KLLSREERL-KNPDLIQAGRFL----
----FGLANEKRVKELEATFGCR---------------M--SPE-IKQ-ELLQCDISRKN
G------------------------------------H-STVADLKELLCCLYESQE-DE
LVKEVMAQ---------------------F-------------------KEISLHLN-AV
DI---APS--S----FCFK-HCPN-LQK-MSLQ----------------VIKK----ETL
-PENVAAS----ES--------------------NTEAER------------SQDD-QDM
LPFWTDLC-SIFGSNKDLMGLEINNSFLSAS---------LVRILC--EQIAS-D-----
SC--H-LQRVV--F-KNISPA--DA----PR-NLCLAL----------------RGHKTV
THLT-LQGT-DQKD--MLPALCEVLRHPECN----LRYL--------GLV---------S
C------S----------------------------------------------------
---------AT---TQ-QWA---DLSLALEA-NRSLMCVNLSDNELLD-EGAKLLYTT--
LRH-PKCFLQRL-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EANCKDLAA-----------------------
--------------------------------VLVVSRELTH---LC-LAKNS-LKD---
-------TGVKFLCEGL----SYPEC----------------------------------
--------------------------KLQ-ALV---------------------------
-------------------------------LWNCDITSDGCCSLAKL-LQEKSSLSCLD
L-GLNHIGVTGVK-VLCEALSKP--LCN----L---------------------------
-----------------------RCLWL--WGC-----SIPPFSCEDL------------
-------CSAL-SCNQSLITLDLGQNPLGSSGVKM-LFKTLT-RP-G--TLQTLR--LK-
--I-DDFNDELHK--------------------LLEEIEENNPQLIIDTEKH----DPWK
---------------KRPSSHD--FM----------------------------------
----I-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MLPA----TARDGLYR

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LSTYLEELE--A---AELKKFKLYLGT------
---------T---AEPG--------Q--DKI-PWGR-METAG-PLEMAQLLVAHMGTREA
WLLALNT----FY-RIHRKDLWERGR-REDLVRAT----V--HN--------GLCSL---
------------------------------------------------------ES----
------------------------------------------------------------
---QS-ASIL-------------------------------GVSPTAPRKDPQETYRDY-
--------IRRK----------------FRLM--EDRNARLGECV---------NLNHRY
TRLLLVKEHSNPIWAQQKLL------DTGQGHAKTMG--------HQASPIQIESLFEPD
EE--RPEPP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RTVVVLGAAGMGKSMLAHKV-----MLDWA--D---------GRLFQ
G--------RFDY-IFYINCKELNRNHV------QCSAQD-LLSR-CW-----PE-PGVP
LQDLLQ-AP----DRLLFIIDGFDE-LRPSFHDA------QG-P-----WCLCWEQK-RS
-TELLLSSLIRKKLLPELSLLIT-TRPCALEKLQGLL-E-----HPR--HVEILGFSEAD
RKEYF----------------Y--RF-FHH---------EEQASQVFSFMTH-NEPLFTM
CFVPMVSWVVCTCLKQQLEGGE-LL-R--QT-SRTTTAVYMFYLLSLMQPKPGT-PTL--
-----------KAPPNQRGLVSLA---ADGL-WN-QK----VLFEDQ-------------
--DLQKHGLDGA-DVSPFLNV----NIFQKDIK-CE-NFYSFIHQSFQEFFAAMYYVMH-
S--RE-------------------------TVR-RVLTEYGFS-QRSFLALTVRFL----
----FGLLNEEMQRYLEKSLGWK---------------V--SPH-IKE-EVLAWIRDKAL
SE-----------------------------------GSTLQRGSLELFSCLYEIQE-ED
FIQEALGH---------------------F-------------------EVVVVSNVA-T
KM-EHVVC--S----FCVR-HCRN-AVV-LHLY----------------GG------AYG
-AGAEDDP--K-DP---------------------------------------SGT---P
------------------------------------------------------------
-------------PERNMLPD-------LYNEHISAAV----------------CTNPNL
IELA-LYRN-ALGSQ-GVQLLCQGLRHPNCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------QVS---GS-ACK---DLAEALIA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NRNLIRMDLSGNGIGL-PGLELLCEG--
LRH-PRCRLQMIQ-----------------------------------------------
------------------------LRKCLLG-----------------------------
----------------------------AAACREIAS-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNPQLVE---LD-LTGNP-LED---
-------SGLKLLCQGL----RHPVC----------------------------------
--------------------------RLR-TLW---------------------------
-------------------------------LKICHLGPMACKDLAST-LSL

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NQRLTELD
L-GLNDLGDPGVL-LLCEGLRNP--GCK----L---------------------------
-----------------------QILRL--GIC-----RLGSDSCGGL------------
-------AQVL-QV

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2373)

NACLRELDLSFNDLGDRGLWL-LGDGLR-HP-TC-RLQKLW--LD-
--S-CGLTAKACE--------------------DLSSTLG

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2465)

TNQTL-TELYLTNNTLGDTG
VRLLCK--------RLRHPGCK--LR--V-------------------------------
---LWLFGM-DLNKMTHRR------LA----------ALR-IGKPYLDIGC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------DPQETYRDY-
--------VRRK----------------FRLM--EDRNARLGEFV---------NLSHRY
TRLLLAKEHSSPRWAQQKLL------DTGRGHAGTAG--------HPASLIQIEALFEPD
EE--RPEPP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RTVVLQGAAGMGKSMLAHKV-----MLDWA--D---------GKLFQ
N--------RFDY-VCYINCREMNRGTA------ELSVRD-LLAS-CW-----PE-PCAP
LQELVR-VP----ERLLVIMDGFDE-LRPSFHEP------QG-P-----WCLCWEKK-AP
-AEVLLGSLIRKKLLPELSLLIT-TRPTALAKLQRSL-E-----HPR--HVAILGFSEAE
RKEYF----------------H--RY-FHD---------REQASQVFSFVRD-DEPLFTL
CFVPMVCWVVCTCLKQQLEGGG-LL-R--RR-SRTTTAVYLLYLLSLMQPKPGT-PTL--
-----------PSPPNRRGLCALA---AHGL-WE-QK----ILFAER-------------
--DLREHGLDAA-DVSSFLNM----NIFQKDII-CE-TLYSFIHLSFQEFFAAMHYVLD-
D--GA--------------S--G--SGPERNLS-RLLTEYAFS-DRSFLALTVRFL----
----FGLLNEETRSYLEKTLGWK---------------V--SPG-VKT-ELLEWIRRKAR
SE-----------------------------------GSTLKQGALEVFGCLYELQE-EE
FIQQALSH---------------------F-------------------QVVVVNNIT-T
KM-EHMVS--S----FCVK-SCRN-AEV-LQLF----------------GA------AYQ
-AHGEDRL--R-WP---------------------------------------LAT---S
H-------------------------SV------------------------I-------
VQ--L--------PERHVLPD-------IYSEQLAAAL----------------STNPSL
VELA-LHSN-ALGSQ-GVKLLCQGLRHPNCR----LQNL--------RLK---------R
C-----------------------------------------------------------
--------QVS---SS-VCQ---DLTTALIA-NKHLLRMDLSGNALGL-LGAQLLCQG--
LRH-PKCRLQVVQ-----------------------------------------------
------------------------LRKCHLE-----------------------------
----------------------------AGACQELAS-----------------------
--------------------------------VLSTSRHLLE---LD-LTGNA-LED---
-------SGLRLLCQGL----RHPVC----------------------------------
--------------------------RLR-ILW---------------------------
-------------------------------LKICLLTGAACEDLAST-LHMNQSLVELD
L-SLNDLGDPGVL-LLCEGLRHP--QCK----L---------------------------
-----------------------QTLRL--CIC-----RLSSVACEGL------------
-------SAVL-GVSSHLRELDLSFNDLGDRGMSL-LCEGLR-HP-TC-RLQKLW--LD-
--S-CSLTGKACE--------------------DISSALGINQTL-TDLYLTNNALGNTG
VRLLCE--------RLSHPGCK--LR--V-------------------------------
---LWLFGM-DLNKMTHRS------LE----------ALR-MTKPYLDVGC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LMWYLKELN--K---KEFMKFKEVLRQ------
---------E--IAESG--------L--QHI-PWNE-VKKAS-REHLANLLVKHYE-QKA
WDVTFRI----FQ-NINRKDLSERAA-EEM------------AG--------------HS
K---------------------------------------------------MYQA----
------------------------------------------------------------
----------------------------------------------------------Y-
--------LKNM----------------LSHD--WSRKFKIAIECF--------------
---------------------------------G-------NEDLTQDNCSRLWNLFVPK
AN---EK-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVLLIGMSGVGKTVFLAQL-----MRAWS--E---------GLMFQ
N--------EFSY-VFYLCCHEIKQLK-------TASLAD-LLSR-EW-----PRP-SAP
IAEIVS-QP----AKLLFIIDSLEG-LNCDWSEP------ES-E-----LCDNWMQK-CP
-VSILLSSLLRRKLLPESSLLIT-ATPEAFEKLGDRI-E-----YTV--KNFVTGFNENS
RRSCF----------------Q--RV-FQD---------EDTAQEVFTLVRE-NEQLYNI
CHVPSLCWMVATCLNDEVKRGG-HL-S--AV-CRCTTSVFAAYVLNLFIPQS-AHYPSK-
-----------KSQALLRGLCSVA---AEGM-WT-DN----FAFNQK-------------
--DLEKNGVFHS-DISTLLNM----KILLKSRD-SK-NLYTFFHPSIQEFCAALFYLVN-
SHVDH-----------------P--SKDVLCVE-TLLFTFLKK-VRVQWIFLGCFI----
----FGLLHKSEQAKLEAFFGYQ---------------L--SQE-VKQ-TLCQSLEKISA
DKE-----------------------------------LRKQIDDMKLFYCLFELED-DG
FVTQVMTF---------------------L-------------------PQIKFVAKEYS
DL---IVA--A----YCLK-NCST-LQN-LSIS----------------TQD-----ILW
-KEN--DP-----------I-----------------------------------YLKKL
LLRWQDLC-SVLGSSEQIQVLQVKDTYLDEL---------AFLELY--NHLKNP------
RC--A-PQTFQVNN---------VTL-W-YNQLFFELL----------------TQNHNL
HHLD-LSLT-CLSHS-DVKLLYDALNQEECH----IEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SGCQLS-----------------------------
----------------------------HDDCIIFAS-----------------------
--------------------------------ILISSKKLRH---LN-VSYNN-LD----
-------KGMYLLSKAL----CHPDCVLKDL-----------------------------
------------------------------------------------------------
------------------------------VLASCSLSKQCWNYLSDV-LKR

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NKTLSHLD
V-SSNDLQDEGLK-VLCQALSLP--DSA----L---------------------------
-----------------------KSLFL--RRC-----LITSSGCQYL------------
-------AEVL-S

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

SNQNLISLQVSNNKLEDAGVKL-LCEAIK-EP-NC-RLENLG--LE-
--A-CELTGASCE--------------------YLVSALSQNETL-WAINLLKNALDLRG
LAMLFE--------ALNVHGCS--PN--V-------------------------------
---LGLQIT-IPDKETQEL------LI----------AEK-KKNPYLAILSR-V------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAMTKA-RNPREA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALSDLE--E---NDFKKLKFYLRD------
---------M--TLSEG--------Q--PPL-ARGE-LEGLI-PVDLAELLISKYGEKEA
VKVVLKG----LR-VMNLLELVDQLS-HVC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LH--DYREIYREH-
--------VRC-----------------LE------EW---QEA----------GVNGRY
NQVLLVA-KSSSESPESPAH------PI-------PE-----Q-ELDSV--MVEALFDSG
EK--PSLAP----SLVVLQG-------------------------------------L

PF05729 // ENSGT00900000140813_0_Domain_2 (719, 940)

YP
G--------RFDY-VFYVSCKEVVLLLE-------SKLEQ-LLFW-CC-GD-----NQAP
VTEILR-QP----ERLLFILDGFDE-LQRPFEEK------LK-K-----RG-----L-SP
-KESLLHLLIRRHTLPTCSLLIT-TRPLALRNLEPLL-K-----QAR--HVHILGFSEEE
RARYF----------------S--SY-FTD---------EKKADSAFDIVQK-NDILYKA
CQVPGICWVVCSWLKGQMERGK-AV-L--ET-PRNSTDIFMAYVSTFLPPVD-DGGCSEF
----------S-RHRVLRSLCSLA---AEGI-QN-QR----FLFEEA-------------
--ELRKHNLDGPRLA-AFLSS----NDYQLGLA-IK-KFYSFRHISFQDFFHAMSYLVK-
EDQSQL----------------G--KESRREVQ-RLLEAKEQE-GNDEMTLTMQFL----
----LDILKKDSFLNLELKFCFR-----------------ISPC-LAQ-DL-KHFKEQM-
E-------------------------------------SMKHNRTWDLEFSLYEAKI-KN
LVKGIQMN---------------------D-------------------VSFKIKHSN-E
KK-SQSQN--S----FSVK-SSLS-HGP-KEKQ------------------KC----PSV
---HGQKEGK---DNI--A-------------------GTHKE-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AST----------------GKG---------R
-GTEE-TDEEVRS-PKN--TYI----YT--------------------------------
------------------------------------------------------------
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------------------------------------

------------------------------------------------------------
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-------------M-GDMNLSS--------------DPSSCPSSP-----------LS-P
S---GVSPPSLESSSSSTLPFR

PF02758 // ENSGT00900000140813_0_Domain_0 (203, 326)

NG---VMPFMLSVS--A---EHLQRFKQLLVE------
---------E--NPRPG--------C--SPL-TWDQ-LKSAR-CGELVHLLTEYFPGQRA
WEMARDI----FA-KMNQTELCLQTQ-RELNEILP-NLEPEALSLR------K-------
------------------------------------------------------------
------------------------------------------------------------
-------REL-------------------------------TLEEDES--DKIREYKAR-
--------VMSE----------------HSTL--WDRTSWPGNNVDFFYQEP--------
----------------------------------------------CREDTLLQCLLLPR
KP--QGRQP----K

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLQGDAGVGKTTVAKKV-----MQQWA--E---------NKFYA
H--------KGWL-AFYLHCQEMDRPE-------EQSFSE-LIAC-KL-----SG-SPAL
ASRILS-HP----EHLLLLLDGFEE-LTLTLI------DRRE-D-----LSEDWSQK-MP
-GSVLLTSLLSKRMLPDATIIVF-LRFSLWKTVGPFL-N-----SPS--LITLMGFSAPE
RSRYF----------------R--SY-FKN---------RRDADAALRFAMG-NAVLFSM
CRVPVICWLVCSCLKQQMERGS-SL-P--RA-FPNATAVFIHYLSSLLPTRV-RHVVGET
------------PQEQLKRLCSLA---VEGM-WK-NQ----WVFSEM-------------
--DLKLARLDDR-DVEVFLGV----RVLRRAVA-GG-DLIAFAHPSFQEFFAALLFVLC-
FPQRL--------------RNFQ--VLDRFRIF-QLLAHPG-R-RKNHLAGMALFL----
----FGLLNDTCALAVEQLFGCK---------------V--SLG-NKR-KLLKVATMPPD
GD-----------------------------------PLTPQHGLPQLFYCLHEIRE-EV
FVGQILHN---------------------H-------------------RKALLVISKIR
DL---QVS--A----FCLK-FCRQ-LRE-LEVT----------------ISW-----AVA
-KATSLSP----GP-------------------------------LPSP--QPEGS-DLR
SLWWQDFC-SVFKTHESLEVLTVRDSVMDTE---------AVETLA--AALRH-P-----
HC--N-LRKLI--F-KRVGSL--VV---S-E-GIIRVL----------------VENQYL
RHLQ-IQDT-EVGCQ-VIDALCNTLKHPWCF----LQFL--------RLE---------G
C------P----------------------------------------------------
---------FD---PS-NGA---DLTRSLKR-NIHLKTLMLRRGSLER-GEECPP-----
--V-LAPQLERL-S----------------------------------------------
------------------------LENCDLT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------PLSCESLAFS-LVSNQSLTHLS
L-AENALQDDGVK-QLWNILQHF--PCP----L---------------------------
-----------------------QRLVL--RNC-----ALTSECCQDI------------
-------ASAL-DKNKTLRSLDLGANRLRDSGVVL-LCQPLL-NP-DS-GLQVLE--LE-
--E-CQFTSICCP--------------------ALTSVLLHNRTL-RYLDLSGNGVGLQG
AKLLQD--------AALKRVLR--PE--V-------------------------------
---V------LYV-P---------------------------------------------
------------------------------------------------------------
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------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------VEHR--

PF02758 // ENSGT00900000140813_0_Domain_0 (198, 332)

AAVARDL---LLAALEDLS--Q---EQLKRFRHKLRD------
------------ASGGS-----------RSI-PWGR-LERAD-ALDLVERLVEFYGPEPA
LEVARKA----LK-RSDVRDVATRLK-EQRLQC---------L---------GPG-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------PE-VELSVSEYKRTYRAH-
--------VLLL----------------HAKV--KERNARS------------VKITKRF
TKLLIAPESAAPR-P--TMRPPE-------EPVP--------RRARRSNTDTFNRLFGRD
E---EGERP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

LTVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYH
G--------QVDF-AFFLCCHELLEQAC------ARSLGD-LVLE-QC-----PD-RRAP
VRQILA-QP----ERLLFILDGADE-LLAAGSA--------EAA-----PCSDPFEA-VS
-GARLLGALLSKALLPSARLLVT-TRAALPAQLQGPL-R-----SPQ--CAEVRGFSDKD
KKKYF----------------Y--KF-FLD---------ERTAERAYRFVKE-NETLFAL
CFVPFVSWIVCSVLRRQLERGQ-DL-S--RT-SKTTTSVYLLFLISLLSSAPPAKEA---
-----------GLQGELRKLCRLA---REGVLGR--R----AQFTEQ-------------
--DLARQELRGSNVQGLFLSQKEMPGLLEA-----E-VAYQFTDHSFQEFFAALSYLLE-
EDASP-------------------E-VPAGSVE-ALLRGDTEL--RGHLTLTTRFL----
----FGLLSAERMGDIERYFGC-----------------VVSKR-VKQ-DALQWVLGQGR
PP-----ATPEGAEGLQGPEGAEEQEE-------EVEEEEEANYPLELLYCLYETQE-AE
FVRQALHG---------------------L-------------------PELTLERLRFS
RT-DVAVL--S----YCVQ-HCPR-GQA-LQLR------------------GC----GLN
------VV----------------------------------------REK--K---RKS
----------------------------------------LVKR----------------
------LQSS---L--------------GGR------N----------------SQ-SGQ
KQ---RQVS-------PLRPLCEAMVDPHCG----LSSL--------TLS---------H
C-----------------------------------------------------------
--------KLP---DS-VCR---DLAEALRL-APALTELDLQHNSLS-DMGLKVLCEG--
-LAWPRCQVQTL------------------------------------------------
----------------------------RVQ-----------------------------
---------------QPSL---------QKGLQYV-------------------------
------------------------------VSLLQQRPALAT---LD-LHGC-QLPEDTV
--K--------YLCATL----QHPACSLQSL-----------------------------
------------------------------------------------------------
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---------------MSLDIQCEQ-LSD-ARWT----------------EL---------
----LPLI-------------------------------QQYEVV------RLEDC-GLT
EVRCKDIS-SAVQA

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELSLRTNELGDG---------GVGMVL--QGLQN-P-----
TC--K-IQKLS--L-QNCGLT--EA---GCG-ILPGML----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LSTL
RELH-LNDN-PMGDA-GLKLLCEGLQDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LT---AT-SCE---PLASVLRV-KADFKELVLSNNDLHE-PGVRILCQG--
LKD-SACQLESL-K----------------------------------------------
------------------------LENCGIT-----------------------------
----------------------------AANCKDLCD-----------------------
--------------------------------VVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLQE---LD-LSSNK-LGN---
-------AGIAALCPGL----LLPSC----------------------------------
--------------------------KIR-TLW---------------------------
-------------------------------LWECDITAEGCKDLCRV-LRA

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

KQSLKELS
L-ASNELKDEGAR-LLCESLLEP--GCQ----L---------------------------
-----------------------ESLWI--KTC-----SLTAASCPYF------------
-------CSVL-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNRSLLELQMSSNPLGDEGVQQ-L

ENSGT00900000140813_0_Linker_15_16 (2378, 2390)

CKALS-QP-DT-

PF13516 // ENSGT00900000140813_0_Domain_16 (2390, 2436)

VLRELW--LG-
--D-CNVTNSGCS--------------------SL

ENSGT00900000140813_0_Linker_16_17 (2436, 2442)

ANVLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NRSL-RELDLSNNCMGGPG
VLQLLE--------SLKQPSCT--LQ--Q-------------------------------
---LVLYDI-YWTNEVEDQ------LR----------ALE-EERPSLRIIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------DKEAHKML-
--------IRKK----------------L--Q--EERCLHNRIHDIFCQDMI--------
----------------------------------------------LELVNKFDFVFHHV
SP--EAAKA----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

LNVFLIGQEASGKTMVLRGA-----LFEWA--N---------GNLWA
D--------VFSY-VIHLSSHDINQMT-------SGSLVA-LISK-DW-----PE-GRAP
VADILS-EP----QKILFILEDLDN-VEHSFRIS------PQ-A-----LCSDGRQQ-VS
-TPVLVASLLTRKLAPGCRFLIT-SRPQGQAVTWTIM-K-----KTD--MLMTLSFAREK
RHKYF----------------T--IF-FRD---------GQRAEAAFQLVQR-NELFLHL
CQVPILCWVTCVALQRQMNQG-ADL-K--RS-CQTLTDIYTHFLAETLTAQA----AD--
----------QRPVVPLQSLCSLA---LEGL-LH-NT----LHFTEE-------------
--DLRGVGFTQA-DVSTLQTL----EILWPSSH-MK-GHYRFIHSKVQEFCAAVAFMLPL
VQHGI-----------------P----SAWG-R--C--KGKRE-LYDDFSPVIASM----
----FGLLNKKRRKTFETALGCR---------------LL-TDY-VSQ-YLLMETRCFGD
NL-------------------------------------KAIGHHTPLFHGLFENQE-EE
YVKRIMDS---------------------F-------------------SEANIYVRDHR
DL---MVS--S----YCLG-YCQH-LQK-LKLS----------------IQN-----IFE
--KRS-NE-------------------------------------------QSTPRTIRS
LVHWRDVC-TLLHTRETLRELELCNTDLDDT---------SDRVLC--KALSHP------
DC--Q-LRTLKLTY---------FSV-DTRFEEMFKAI----------------VHNRNL
TCLC-LSCM---------------------------------------------------
------------------------------------------------------------
--------------------------------------------PISS-KVFSLLHEV--
LAN-PRCSIQHL-S----------------------------------------------
------------------------LMKCDLE-----------------------------
----------------------------TSAYQELAS-----------------------
--------------------------------LLLSSKNLKK---LT-LSKNA-LSR---
-------DGMEVFCDAL----FHPNCVLESL-----------------------------
------------------------------------------------------------
------------------------------VLLFCCLTLRSLSLISRS-LVLTETLKHLD
V-SVNNIRDNGVL-VLMMSLVFP--TCS----V---------------------------
-----------------------QELEM--SGC-----FFTAKACEYM------------
-------VCVLQ-NNP

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2405)

NLKSLELGSNNVGDAGLAP-T-------P-LC--ISPHR--LE-
--E-CMLTSACCA--------------------SLASVLISSKTL-RKINLLGNNLGDEG
IVQLLE--------GLGHPDCV--LQ--S-------------------------------
---VGLDIK-NMNAETMTL------FM----------TVR-NKNTHLHVTDQSWAKKEGR
EV----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
---------SVLTANENLGELRVSDSNLPGP---------ALVTLS--NHLKHP------
RC--R-LQKLKMNN---------VSF-SAESRFFFEVF----------------TQSPVL
KHLD-LSDT-RISHD-DFKLLCNALNNPACN----IENL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------VECGLL-----------------------------
----------------------------ADDCEGLKE-----------------------
--------------------------------VLMRNT

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2057)

KLKV---LD-LSYNC-LG----
-------NGLSLLCEAL----CLPACALRGL-----------------------------
------------------------------------------------------------
------------------------------GLVDCCLREPCWERLRDV-VLINRNLTHLD
L-STNGLEDKDLN-LLGEALKQP--SCY----L---------------------------
-----------------------KSLSL--FNC-----FITANGCQDL------------
-------ASIL-TGNP

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2381)

NLRNLQIGHNNIEDDGVRL-LCEALL-HP-NC-HLENLG--LD-
--A-CQLTSACCE--------------------DLASVLRGSRCL-KELNLAGNPLGHHG
VQLLCA--------ALRHPECG--LQ--T-------------------------------
---LELEKA-EFDEETQEL------LV----------AEE-ERNPCLTITH---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFISDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LMWYLKELN--K---KEFIKFKEFLIQ------
---------E--ILKLK--------L--KQI-SWTK-VKKAS-REDLANLLLKCYEENQA
WDMTFNI----LQ-KINRKDLTERAT-EEIADSSPLGLTD--SG--------------NP
K---------------------------------------------------LYRD----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKK----------------LTHD--CSKKFNVRIQDF--------------
---------------------------------I-------KETFIQNDYDTFENLLISK
GT--EKK-P----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

MVFLQGMAGIGKTMMLKNL-----MLAWS--K---------GLVFQ
N--------KFSY-TFYFCCQDMKQLK-------TASLAE-LISR-EW-----PSP-SAP
IEEILS-QP----EKLLFIIDSLEG-MECDLTKQ------ES-E-----LCDNCMKK-QP
-VSILLSSLLTRKMLPESSFLLS-TTPETFEKMEDRI-L-----CTD--VKTATAFDERS
IKIYF----------------H--RL-FQD---------KIRAQEAFSLVRE-NEQLFSI
CQVPLLCWMVATCLKKEIEKGR-DP-V--SV-CRHITSLYTTHILNLFIPQS-AQYPSK-
-----------KIQEQLQGLCSLA---AEGM-WT-DT----FVFGEE-------------
--ALRRNGILDS-DIPTLLDI----GMLGKIRE-FE-NSYIFLHPSVQEVCAAIFYLLK-
SHVDH-----------------P--SQDVKSIE-TVLFMFLKK-VKTQWIFLGCFI----
----FGLLQKSEQEKLVVFFGRR---------------L--SQK-IQH-KLYQCLETISG
NAE-----------------------------------LQEQIDGMKLFSCLSEIED-EA
FLVKVMSY---------------------M-------------------QQINFVAKNYS
DL---ILA--A----YCLK-HCST-LKK-LSFS----------------TQN-----VLN
-EKG--GQ-----------R-----------------------------------CMKKL
LICWNDMC-SVFVRSKDIQVLQIKDTSFSEP---------AIRVLY--ESLKYP------
SF--T-LNKLVANN---------VHF-FGDNHMFFEL-----------------IQNCSL
QYLD-LGCS-FLTHS-EVKLLCDILNQAECN----IEKL--------V------------
------------------------------------------------------------
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------------------------------------

------------------------------------------------------------
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-----------MAGG----A-WGR---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LACYLEFLK--K---EELKEFQLLLAN------
---------K--AHSR--------SS--SGE-TPAQ-PEKTS-GMEVASYLVAQYGEQRA
WDLALHT----WE-QMGLRSLCAQAQ-EGAG-------HS-PSFPY---SPSEPHLGSPS
QPTSTAVLMPWIHELP-----AGCTQGSERRVLRQLPDTSGRRW-REISASLLYQ--A--
---------LPSSPD-HESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLD
ETSGIYYTEIREREREKSEKGR------PPWAAVVGTPPQAH---TSLQPHHHPWEPS--
--------VRES----------------LCSTWPW-------KNE---------DFNQKF
TQLLLLQRPHPRSQDP---L------VKRSWPDYV--------EENRGHLIEIRDLFGPG
LD--TQ-EP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RIVILQGAAGIGKSTLARQV-----KEAWG--R---------GQLYG
D--------RFQH-VFYFSCRELAQSK-------VVSLAE-LIGK-DG-----TA-TPAP
IRQILS-RP----ERLLFILDGVDE-PGWVLQEP------SS-E-----LCLHWSQP-QP
-ADALLGSLLGKTILPEASFLIT-ARTTALQNLIPSL-E-----QAR--WVEVLGFSESS
RKEYF----------------Y--RY-FTD---------ERQAIRAFRLVKS-NKELWAL
CLVPWVSWLACTCLMQQMKRKE-KL-T--LT-SKTTTTLCLHYLAQALQ--------AQ-
-----------PLGPQLRDLCSLA---AEGI-WQ-KK----TLFSPD-------------
--DLRKHGLDGA-IISTFLKM----GILQEH---PIPLSYSFIHLCFQEFFAAMSYVLE-
D------EKG--------RGKHS--NCI-IDLE-KTLEAYGIH--GLFGASTTRFL----
----LGLLSDEGEREMENIFHCR---------------L--SQG-RN---LMQWVPS---
------------------------------------LQLLLQPHSLESLHCLYETRN-KT
FLTQVMAH---------------------F-------------------EEMGMCVETDM
EL---LVC--T----FCIK-FSRH-VKK-LQLI----------------EGRQ-------
------H-R---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------S------------
------TWSP--------------------------------------------------
-------------------TMVVLFRWVPVT-----------------------------
----------------------------DAYWQILFS-----------------------
--------------------------------VLKVT

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

RNLKE---LD-LSGNS-LSH---
-------SAVKSLCKTL----RRPRCLLETLR----------------------------
------------------------------------------------------------
-------------------------------LAGCGLTAEDCKDLAFG-LRA

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NQTLTELD
L-SFNVLTDAGAK-HLCQRLRQP--SCK----L---------------------------
-----------------------QRLQL--VSC-----GLTS------------------
------------------------------------------------------------
---------DCCQ--------------------DLASVLSA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SPSL-KELDLQQNNLDDVG
VRLL

ENSGT00900000140813_0_Linker_17_18 (2465, 2716)

CE--------GLRHPACK--LI--R-------------------------------
---LGLDQT-TLSDEMRQE------LR----------ALE-QEKPQLLIFS-RRKPSVMT
PTEGLDTGEMSNS-----------------TSSLKRQRLGSERAASHVAQANLKLL-DVS
KI------FPI-AEIAEESSPEVVP-VELLCVPSPASQGD-LHTKPLG-TDDDFWGPTGP
VATEVVDK-EKNLYR

PF13553 // ENSGT00900000140813_0_Domain_18 (2716, 2997)

VHFPVAGSYRWP---NTGLCFVMREAV-------TVEIEFCVWDQ
FLGEINPQHSWMVAGPLLDIKAEPGA-VEAVHLPHFVALQGG--------HVDTSLFQMA
HFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEE
V-TFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGS-------GS
GMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG

ENSGT00900000140813_0_Linker_18_19 (2997, 3052)

DLMP
ATTLIPP-----------------------------ARIAVPSPLDAPQLL

PF00619 // ENSGT00900000140813_0_Domain_19 (3052, 3134)

HFVDQYREQ
LIARVTSVEVVLDKLH-GQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQA
LKETHPHLIMELWEKGSKKGLLPLSS----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MREAKIAPLS

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 326)

NYG---LQWCFEQLG--K---EEFQTFKALLKE------
---------H--ASESA--------A--CSF-PLVQ-VDRAD-AESLASLLHEHCRASLA
WKTSTDI----FE-KMSLSALSEMAR-DEMKKYLL-AEISEDSAPTKT--DQGPSMKEVP
G-----------------------------------------------------------
------------------------------------------------------------
---------------------------------------------PREDPQDSRDYRIH-
--------VMTT----------------FSTR--LDTP-QRFEEF---------------
-----------------------------------AS-------ECPDA-HALSGAFNPD
SS--GGFRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 905)

TVVLHGPPGVGKSSLARRL-----LLFWA--Q---------GDLYK
G--------LFSY-VFLLRARDLQGSR-------ETSFAE-LISK-EW-----PD-APVP
VEKVLS-QP----ERLLIVVDGLEE-LELTFRDQ------DS-S-----LLADWAER-QP
-APVLAHSLLKKVLLPECALLLT-VQDAGLQRLQALL-R-----SPR--YLWVGGLSVEN
RMQLL----------------L--GG-GKH---------CRRKTCAWHAGAD-HQEVLDK
CQVPVVCALVREALELQGEPGK-GL-P--VP-GHTLTGLYATFVFQRLAPKD-AGWRALS
----------GEERCALKGLCRLA---ADGV-WN-AK----FVFDGD-------------
--DLGVHGLQGP-ELSALQQA----SILLPDGH-CGRG-HAFSHLSLQEFFAALFYVLR-
GVEGD--------------GEGY--PLFPQSTK-SLTELRHID-LNVQLVQMKRFL----
----FGLVSKEVMRALETLLGCP---------------V--AP-VAKQ-QLLHWICLLGQ
HPA----------------------------------A-AASPDLLEAFYCLFETQD-DE
FVRLALNG---------------------F-------------------QEVWLQLNRPM
DL---TVS--S----FCLR-RCQH-LRK-VRLD----------------VRG-----T-P
-KDEFAEA----WS--------------------GA-----------PQ--GLKIK-TL-
DEHWEDLC-SVLSTHPNLRQLDLSGSVLSKE---------AMKTLC--VKLRQ-P-----
AC--K-IQNLI--F-KGARV---TP---GLR-HLWMTL----------------IINRNI
TRLD-LTGC-RLREE-DVQTACEALRHPQCA----LESL--------RLD---------R
C------G----------------------------------------------------
---------LT---PA-SCR---EISQVLAT-SGSLKSLSLTGNKVVD-QGVKSLCDA--
LKV-TPCTLQKL-I----------------------------------------------
------------------------LGSCGLT-----------------------------
----------------------------AATCQDLAS-----------------------
--------------------------------ALIENQGLTH---LS-LSGDE-LGS---
-------KGMSLLCRAV----KLSSC----------------------------------
--------------------------GLQ-KLA---------------------------
-------------------------------LNACSLDVAGCGFLAFA-LMGNRHLTHLS
L-SMNPLEDPGMN-LLCEVMMEP--SCP----L---------------------------
-----------------------RDLDL--VNC-----RLTASCCKSL------------
-------SNVI-TRSPRLRSLDLAANALGDEGIAA-LCEGLK-QK--N-TLTRLG--LE-
--A-CGLTSEGCK--------------------ALSAALTCSRHL-ASLNLMRNDLGPRG
MTTLCS--------AFMHPTSN--LQ--T-------------------------------
---IGLWKE-QYPARVRRL------LE----------QVQ-RLKPHVVISDAWYTEE---
--E---------------------------------------------------------
--------------------------------------------------EDGPCWRI--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSLDIQCEQ-LSD-ARWA----------------EL---------
----LPLL-------------------------------QQCQVV------RLDDC-GIT
EARCGDIS-SALRV

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELSLRSNELGDA---------GVHCVL--QGLQS-P-----
SC--K-IQKLS--L-QNCYLT--GA---GCG-VLSGTL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LPTL
QELH-LSDN-LLGDA-GLQLLCEGLLDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LS---AA-SCE---PLASVLRA-KPDFKELTVSNNDINE-AGVRVLCQG--
LKD-SPCQLEAL-K----------------------------------------------
------------------------LESCGIT-----------------------------
----------------------------SNNCRDLCS-----------------------
--------------------------------IVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLRE---LA-LGSNK-LGD---
-------VGIAELCPGL----LHPSS----------------------------------
--------------------------SLR-TLW---------------------------
-------------------------------IWECGITAKGCADLCRV-LRTKE

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-AGNELGDEGAR-LLCETLLEP--GCQ----L---------------------------
-----------------------ESLWV--KSC-----SFTAACCSHF------------
-------SSVL-AQS

PF13516 // ENSGT00900000140813_0_Domain_15 (2356, 2378)

KFLLELQISNNRLADVGVQE-LCKGLG-QP-GS-VLRVLW--LG-
--D-CDMSDSSCS--------------------SLAATLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NHSL-RELDLSNNCLGDAG
VLQLVE--------SVRQPGCL--LE--Q-------------------------------
---LVLYDI-YWSEAMEDR------LQ----------ALE-EEKPSLRVIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSLDIQCEQ-LSD-ARWA----------------EL---------
----LPLL-------------------------------QQCQVV------RLDDC-GLT
EARCGDIS-SALRV

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELSLRSNELGDA---------GVHCVL--QGLQS-P-----
SC--K-IQKLS--L-QNCYLT--GA---GCG-VLSGTL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LPTL
QELH-LSDN-LLGDA-GLQLLCEGLLDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LS---AA-SCE---PLASVLRA-KPDFKELTVSNNDINE-AGVRVLCQG--
LKD-SPCQLEAL-K----------------------------------------------
------------------------LESCGIT-----------------------------
----------------------------SNNCRDLCS-----------------------
--------------------------------IVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLRE---LA-LGSNK-LGD---
-------VGIAELCPGL----LHPSS----------------------------------
--------------------------SLR-TLW---------------------------
-------------------------------IWECGITAKGCADLCRV-LRTKE

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-AGNELGDEGAR-LLCETLLEP--GCQ----L---------------------------
-----------------------ESLWV--KSC-----SFTAACCSHF------------
-------SSVL-TQ

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NKFLLELQISNNRLGDAGVQE-LCKGLG-QP-GS-VLRVLW--LG-
--D-CDMSDSSCS--------------------SLAATLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NHSL-RELDLSNNCLGDAG
VLQLVE--------SVRQPGCL--LE--Q-------------------------------
---LVLYDI-YWSEAMEDR------LQ----------ALE-EEKPSLRVIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------KINPYRKH
------------M-KEKFHLIWEK------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------ETCLQVPDS--------------
---------------------------------F-------YRETIKKEYE----ELN-N
VF--ETSEA----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RQVVLKGAEGSGKTTLLRKA-----MLDWT--E---------GNFWK
G--------RFRF-VFFLSARELNCVT-------ETSLVE-LISR-DW-----PES-SEP
IEDIFS-QP----QDILFIMDGFEE-LKFALL-L------KN-N-----TSDDWRQQ-QP
-IEIILSSLLQKKMLPESSLLIA-LGLVGMQKNYSLL-Q-----HPK--YIVLSPFSEHE
RKLYC----------------C--HF-FQE---------KNKAMKAFSYVKD-NTFLFAL
CQNPLLCSLTCCCIKKQLEKGE-DL-E--IA-CQSTTSLYVYFFIHIVKAGC-E------
------------NRAQLKGLCSLA---AEGI-WT-HT----YLFCLG-------------
--DFRRKGVSES-SVLRWLGM----SLLRRSG-----DCITFIHKHVQEFCAAMFYLIK-
EPKDN-----------------S--HPVVGSIT-RFIATAQP---KASLPQMGLFL----
----FGLLTEKVTKILETSIGFQ---------------L--SQG-IKQ-EIIQGLKNLSK
CA-----------------------------------SSETELVFQDLFFCIYETRE-KE
FTAQVMNF---------------------F-------------------KEVIVYISSTE
EL----TS--S----YCLK-HCRI-CSG-XXXX----------------XXXXX-XXXXX
-XXXXXXX-----------X-------------------N------------------WL
LNFWQDLC-SVFSTNKNLQVLELDNCRFSED---------SLVILC--EALAHP------
TC--K-LHRLLLHC---------VST-TGERADFFWAV----------------LQKPHL
KYLN-LHDT-GLSYA-AVIQLSEMLKLPTCS----VEKL--------ML-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GNCDIT-----------------------------
----------------------------DNKCEDIAS-----------------------
--------------------------------VLMCNNKLKL---LS-FVENP-LDD---
-------EGTKVLCYAL----KHPXXXXXXX-----------------------------
------------------------------------------------------------
------------------------------XLNHCCLSSVSCDYIAQV-LLCNQFLTLLD
L-GSNILKDDGVN-SLCKALKSP--NCH---

PF00560 // ENSGT00900000140813_0_Domain_14 (2252, 2355)

-L---------------------------
-----------------------EELWL--SNC-----FLTSDCCKDI------------
-------ASVL-TSNQKLRTLKLGKNYILDLGVKL-LCVALK-HP-NC-KLENLG--LE-
--M-CRLTSACCE--------------------DLASALTVCKTL-RCLNLQCNTFDHEA
VMVLC---------ALSHLHCD--LQ--T-------------------------------
---LGLNKC-AFAEGTQLL------LT----------AVE-EKKPHLAIIRQPWADN---
--EAE-----VT------------------------------------------------
--------------------------------------------------GVLFR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MTHFSEDDGSPSNYFPR-
--------HIET----------------FCVV--WNKDPLLGEHAD---TIT--------
----------------------------------------------EKERKLLEHLFDMD
VT--NGEQP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

LVVLLGAAGVGKTTLMRKA-----MLDWA--E---------GNLYQ
Q--------KFTY-VFYLSGREICQMK-------ERSFAQ-LISK-DW-----PS-TEIP
IEKILS-QP----RNLLFIIDSFDE-LSFAFEEP------EF-A-----LCKDWAQV-HP
-VSFLMSSLLRKVMLPESTLLVT-TRVTSSKRLKPLL-K----K-PH--YVKLLGICESA
RIDYI----------------Y--QF-FKD---------KAQAIEAISAVRN-NETLFNM
CHAPLTCRLICSCLEQQMEKGG-NV-T--EI-CQTTTALFTSYISNLFAREEDGGSSSRP
------------NEALLRSLCQMA---AQGV-WT-MT----HMLYRD-------------
--SLRKHELTRT-DISVFLDM----NILQKDTE-HE-NCYMFTHLQVQEYFAALLYLLK-
DGWET--------------RDRS--LKPFANMK-TLLESRHYH--ALHLTQMKQFL----
----FGLLNEARVKHLEETLNCT---------------L--SLE-IKG-EVLKWIENLGS
SN-----------------------------------YSPTQLGLLDLFHLLYETQD-EV
FVTQAMSY---------------------F-------------------PNVVINIYEET
HL---LVS--S----FCLK-NCQR-LQT-LKLI----------------ITM-----IFI
--K---M------------------------------------------------DNSHC
SQCWRDLC-SVLHTNKHLRELDLANSNLDKE---------ILTILN--EELRLP------
SC--K-LQKLLLSS---------VYF-LDGCKDFFSFL----------------PYNKNL
THLD-LKES-DIIDR-DVKSLCEVLKDPECK----LQNL--------RLD---------S
CN----------------------------------------------------------
---------VT---AV-CCV---NISKVLIE-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NHSLVYLSLSTNKLLD-DGVKLLCEA--
LGN-PECSLERL-S----------------------------------------------
------------------------LESCGLT-----------------------------
----------------------------EAACRDLSQ-----------------------
--------------------------------ALI

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNNRLTH---FC-LAYNN-VGD---
-------NGVKLL

ENSGT00900000140813_0_Linker_11_12 (2054, 2126)

SDAL----EHPQC----------------------------------
-------------------------

PF13516 // ENSGT00900000140813_0_Domain_12 (2126, 2206)

-TLQ-SLV---------------------------
-------------------------------LRNCHLTPRGGEYL

ENSGT00900000140813_0_Linker_12_13 (2206, 2212)

STS-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

HNKSLTHLD
L-ASNGLMNDGTK-LLCNVS----------------------------------------
--------------------------------C-----DL----TSDL------------
-------ASAI-V

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2374)

NCPNLWSLDLGNNRLENEGVKI-LCGALR-HP-DC-NIQCLG--LQ-
--N-CDLTFGCCQ--------------------DLSSSLLSNQRL-LQLNLTKNIIGYEG
IRDLCE--------VLRYPECS--LF--L-------------------------------
---FRLCKG-KTDKESSKL------LE----------AVG-VSNPHLVIKSHYDYHP---
--E---------------------------------------------------------
--------------------------------------------------EDGSWWQCF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------YRER-
--------MKAK----------------ILMM--WDNMPWPEGHIYLRNVTE--------
----------------------------------------------K-EHKELKSLLYPN
R---MGAQP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TIVLEGVAGVGKTTLAMKA-----MLHWA--E---------GFLFQ
Q--------RFSY-VFFISCHKVKEVK-------DTTFAG-LLSW-DW-----PD-SQPP
FEELMS-HP----ERLLFVIDGFEE-MDMPSN------LDAS-P-----PCTDWFQR-LP
-VHRILFYLLRKELVPGATLLIT-TKEYRTKDLKKLL-L-----DPW--FVQISGFTEGD
REEYF----------------I--RY-FGD---------QNKAKKILRWVRK-NENLFYF
CSAPMVCWAVCSCLKWQMARSP-CF-Q--LS-TQTTTSLYVYFFSSLFAKAE-VSLSAQS
------------WPEQWILLCSLA---AEGM-WF-RN----FTFAKE-------------
--DLKHRHLEAS-LIDTLFSL----NILRKVSD-CD-GCVTFTHQSFQVFLGAMFYALG-
GTKGS--------------M-GS--PAKHEEMK-VLLTDALAD-TNFYWNQMALFF----
----FGLLKRNLAGELEATLRCK---------------V--SRR-ITD-ELLEWAEELGS
YD-----------------------------------IVSNCFEFLHFFECLYETQE-EN
FVRQILSP---------------------L-------------------LEADLDIFGNL
QL---QVA--S----FCLK-HCQR-LNK-LRLS----------------VTV-----PIP
-QTELTF-------------------------------------TTETL--ETSSH--SK
IHQWQDVC-S-VFCHGNVRELDMSNSKLNAS---------SMKKLC--YELRS-P-----
RC--K-LQRLT--C-KSVSPV--RV---L-K-ELVLVL----------------HGNQRL
THLN-LSSN-NLGIP-VSTMIFKTLRHSACN----LQYL--------WLE---------S
C------G----------------------------------------------------
---------LT---PL-TCC---HLFAELRK-NSSVRFLSLGDNDLSG-TEEKGLQGP--
STV-STSSLQEL-S----------------------------------------------
------------------------LEKCQLS-----------------------------
----------------------------AAVYRGLAS-----------------------
--------------------------------CLTSTQRTTR---LC-LGFNP-LQD---
-------DGVRLLCSSL----THPEC----------------------------------
--------------------------ALQ-RLV---------------------------
-------------------------------LWFCQLGAPSCKYLSDA-LLENKSLTHLN
L-RRNSLGDEGVK-LLCEALSRP--DCR----L---------------------------
-----------------------QNLDL--SGC-----SLTAGGCQEL------------
-------ANAL-RHNHNVKILDLGSNDVRDDGVIH-LCEALK-DP-SC-ALNTLG--LE-
--K-CNLMPACCQ--------------------HLSSVLGSSKSL-VHLNLLQNDLEPSG
VGILWK--------ALKKSTCK--LQ--K-------------------------------
---LGLKKE-LYD-IVKRE------LE----------ELQ-ERGSFLRVKCKWDFND---
--LE--------------------------------------------------------
---------------------------------------------------DKWWW----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAGG----A-WGR---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LACYLELLK--K---EELKEFQLLFAS------
---------K--VHSS--------GS--SGE-TPAQ-LEKTS-GMEVASYLVAQYGEQRA
WDLALRT----WE-QMELRSLCTQTR-EGAD-------YS-PSFPY---SPSEPHLGSPS
QPTSTAVLRSWNHELP-----AECTQVSERRVLRQLPDTSGHRW-REISSSLLYQ--A--
---------LPSSPD-FESPSQESPNAPTSTAVLASWRSPPQPSLAPREQEAPGTQWPLA
ETSGNYYTGIREREREESEKGR------PPWEAAVGMPPQVH---ASLQPHRHPWEPS--
--------ARES----------------LCSTWSW-------KNE---------DLNQNF
TQLLLLQRPHPRSQKP---L------VKGSWPHDV--------EEDRGRLIEIRDLFGPG
LD--TQ-EP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RIVILQGAAGIGKSTLARQV-----RAAWG--R---------GQLYG
D--------RFQH-IFYFSCRELAQCK-------VVSLAE-LIGQ-DW-----TA-AQAP
IRQILS-RP----ERLLFILDGVDE-PRWVLQEP------SS-E-----LCLHWSQP-QP
-ADALLGSLLGKTILPEASFLIT-ARTTALQNLIPSL-E-----QAR--WVEVLGFSESS
RREYF----------------Y--KY-FTD---------ERQAIRALGLIQS-NKELWAL
CLVPWVSWLACTCLMEQMKRKE-EL-T--LT-SKTTTTLCLHYLSQALR--------AQ-
-----------PLGPQLWDICSLA---AEGI-WQ-KK----TLFNRG-------------
--DLRKHELDGA-IISTLLKM----GILQEH---PLPLSYSFIHLCFQEFFAAMSYALE-
D------RKG--------RGKHS--NCI-IDLE-KLLAAYGTH--GLFGAPTTRFL----
----LGLLSDEGERAMENIFNCR---------------L--SQG-RN---LKQWVPS---
------------------------------------LQPLRQPHSLEFLHCLYETQN-KT
FLTQMMAD---------------------F-------------------QEMGVCVETDM
EL---LVC--T----FCIK-FCRH-VKK-LQLI----------------EGRQ-------
------H-R---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------P------------
------AWSP--------------------------------------------------
-------------------TGIVLFRWVPVT-----------------------------
----------------------------DAYWEILFS-----------------------
--------------------------------VLKVT

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

RNLKE---LD-LSGNS-LSH---
-------SAVKSLCKTL----RRPRCLLETLR----------------------------
------------------------------------------------------------
-------------------------------LASCGLTAEDCKDLASG-LRL

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NQKLTVLD
L-SFNMLTDAGAR-HLCQRLSWP--FCT----L---------------------------
-----------------------QRLQ---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----LDQT-TLSDEMRQE------LR----------ALE-QKKPRLFIFS-TWKPTEMI
PNEGLGTGETSNS-----------------TSSLKRQRLGSETESSHVAQADPKPL-DWS
NPPAKA--SQS-AGITEGSSPEVEQ-VGPLCLPSPASLGD-QD-MPLG-TDDDFWGPMGP
VATEVVDK-ERSLYR

PF13553 // ENSGT00900000140813_0_Domain_18 (2716, 2997)

VHFPVAGSYRWP---NTGLCFVVREAV-------TTEIEFCVWDQ
FLGEINPQHSWMVAGPLLDIKAEPGA-VEAVHLPHFVALQGG--------HVDTSLLQVA
HFKEEGMLLEKPARVELHHIVLQNPSFSPLGVLLKVIHSTLRFLPVNSLVLLYHRLHPEE
V-TFHLYLIPSDCSIRKAIDDEETKFQFVRIHKPPPLTPLYMGCRYTVSGS-------GS
GMLEILPKELELCYRSPGEAQLFSEFYVGHLGSGIRLQMKDKKDETLVWEALVKPG

ENSGT00900000140813_0_Linker_18_19 (2997, 3052)

DLTS
ATTLVPP-----------------------------APIALPSPLDTLGLL

PF00619 // ENSGT00900000140813_0_Domain_19 (3052, 3134)

HFVDQYREQ
LIARVTSVEAVLDKLH-GQVLSQEQYERVLAEDTRPSQMRKLFSSSQSWDRRCKDRFYQA
LKETHPHLIMELWEKGSKKGLLPLSS----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MA---SSFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LMWYLEELK--K---KEFMKFKELLKE------
---------E--TSHLG--------L--KQI-PWAE-VKKAS-REELACLLLKHYEEEQA
WDVTFRV----FQ-RIDRRDLCERAI-RES------------TG--------------HS
K---------------------------------------------------LYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------VREK----------------YSNI--LAKKSIATLHQN--------------
---------------------------------L-------DETITQEEIKSLELLFTPQ
KP--GKQ-A----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

AVLLKGNQGVGKTTFLIKF-----MLAWS--K---------GLIYK
D--------RFSY-VFYFCCQELKQLP-------VTSLAE-LITS-TW-----PST-SAP
VSEILA-HP----EKVLFMVDSFEM-LGSDLGEP------EG-E-----LCRDWVEV-RP
-PQLLLSSLLRRRMVPECSLLIT-VDIKARQSLEDRL-R-----DLD--VRVLGGFRESD
IKLYI----------------Y--GM-FQD---------LHRAAEAFSLIQS-KEWFLAL
CRFPVLCCLAGTALKHEMDEGK-DV-A--RT-FQRTTSLYTSFLFNLFTPRT-TDSPSW-
-----------QGQAQLQTLCSLA---AQGM-WT-NC----FVFWEK-------------
--DLRRNGIEGS-DVPALLEL----GILLRCRG-SE-PSYKFLHPSIQEFCAALFYLLK-
SPGHH-----------------P--HPAVQGTQ-DLLVTFLEK-SRAYWVFLGCFL----
----FGLLHERERQKLDAFFGFQ---------------L--SSE-VKQ-QVYQYLQSLST
VR-----------------------------------NLHERIVFLALFYCLFEMQE-ET
FVSQAMNL---------------------M-------------------QELTFTMSGKL
DL---EVA--A----YCLK-HCSK-LRQ-LSIS----------------IQD-----LPF
-F----FP-----------H-----------------------------------RSNAD
LVCWHQVC-SVLTTNKHLRVLQIKDSVLSDC---------ATGTLL--NQLRQP------
NC--L-VENLMINN---------ARL-HCDSWLLFEVF----------------IHNPNV
KYLS-LNNT-DLCRD-AVRNLCSVLSHPTCV----SCP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RPRG-----------------------------
----------------------------HPDCKAFAS-----------------------
--------------------------------ILMEGRKLKQ---LN-LASNF-LK----
-------KGVRTLCKAL----CHPDCTLQFL-----------------------------
------------------------------------------------------------
------------------------------VLAFCYLSNWCWDYLAEV-LLT

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

SKSLTHLD
L-SLNTLRDEGLK-VLCEALRYP--TCM----L---------------------------
-----------------------KTLSL--MQC-----SITAGGCRDL------------
-------AAVL-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

SNQNLTSLLLAKNHLGDTGVKL-LCGAVA-QP-GC-RLENLG--LD-
--D-CGLTGACCE--------------------DLADMLTSSKTL-TTLSLIQNPLDHCG
VAVLCE--------GLRHPECT--LR--V-------------------------------
---LGLNKA-AFDKKTQAL------LI----------DEE-KRNPNLAVLES--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------LGDCGLT-----------------------------
----------------------------AADSQDLAS-----------------------
--------------------------------ALT

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2050)

KNQSLTH---LY-LASNS-LGS---
-------EGVNLLGRAM----KLPNC----------------------------------
--------------------------SLQ-RL----------------------------
------------------------------ILNACNLDVAGCGFLAFA-LMG

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NRRLTHLS
L-SVNPLEDDGMK-LLCEVMMEP--SCH----L---------------------------
-----------------------QDLEL--VKC-----QLTATCCKSL------------
-------SHVI-TR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NKHLQSLDLAANALGDNGIEV-LCEGLK-QK--N-SLRRLG--LE-
--A-CELTSGCCE--------------------ALSSALSGS

PF13516 // ENSGT00900000140813_0_Domain_17 (2443, 2465)

EHL-TSLNLMQNNFSLGG
MTKLCS--------AFAQPTCD--LQ--M-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------ASFFSDFG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LMWYLEELN--K---KEFVKFKEFLKQ------
---------E--ILQLR--------L--KQI-SWTK-VKKAS-REDLANLLLKHYEEKQA
WDMTFKI----FQ-KMNRKDLIERAG-REI------------AG--------------HS
K---------------------------------------------------LYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKK----------------LTHD--YARKFNIKAQDL--------------
---------------------------------F-------KQKFTQDDCDRFENLLVSK
AT--GKK-P----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

MVFLQGVAGIGKSLMLTKL-----MLAWS--E---------GIVFQ
N--------KFSY-IFYFCCQDVKQLK-------RASLAE-LISR-EW-----PNA-SAP
TAEILS-QP----EKLLFIIDSLEV-MECNMSER------ES-E-----LCDNCTEK-QP
-VSLLLSSLLRRKMLPESSFLIS-ATPETFEKMEDRI-E-----CTN--VKIITGFNENN
IKMYF----------------R--SL-FQD---------KNRTLEAFSLVRE-NEQLFNV
CQVPVLCWMVATCIKKEIEKGR-DP-V--FI-CRRTTSLYTTHIFNLFTPQN-AQYPSK-
-----------KSQDQLQGLCSLA---AEGM-WT-DT----FVFSEE-------------
--ALRRNGILDS-DIPTLLDR----RILERSKE-SE-SCYIFLHPSLQEVCAAVFYLLK-
SHLDH-----------------P--SQDVKSVE-ALLFTFLKK-AKVQWIFLGCFL----
----FGLLHESEQEKLEMFFGHQ---------------L--SQE-IKH-QLYQCLETISV
NEE-----------------------------------LQEQIDGMKLFYCLFEMED-EA
FLMQAMNC---------------------M-------------------EQINFVAKDYS
DV---IVA--A----YCLK-HCST-LKK-LSFS----------------TQN-----ILS
-EEQ--EH-----------S-----------------------------------YTEKL
LICWHHMC-SVLISSKDIHVLQVKDTNLNET---------AFWVLY--NHLKYP------
SC--T-LKVLVVNN---------VTF-LCDNHLFFEL-----------------IQNQRL
QHLN-LSLT-FLSHS-DVKLLCDVLNQAECN----IEKL--------MI-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------AACNLS-----------------------------
----------------------------PDDCKVFAS-----------------------
--------------------------------VLIS

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2048)

SKMLKH---LN-LSSNN-LD----
-------KGISSLCKAL----CHPDCILKHL-----------------------------
------------------------------------------------------------
------------------------------VLANCSLSEQCWDYLSEV-VRR

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NKTLSHLD
I-SSNDLKDEGLK-VLCGALTLP--DSG----L---------------------------
-----------------------ISLSV--RHC-----LITTSGCQDL------------
-------AEVL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNQNLRSLQVSNNKIEDAGVKL-LCDAIK-QP-NC-HLENIG--LE-
--A-CELTGACCK--------------------DLASAFVHCKTL-WGINLLENALDHSG
LVVLFE--------ALKQQKCT--LH--V-------------------------------
---LGLRIT-DFDKETQEF------LI----------AEE-EKNPYLSILSN-VT-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MADSSSSSFFPDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LLLYLEELN--K---EELNTFKLFLK-------
---------E--TMEPE--------H--GLT-PWTE-VKKAR-REDLANLMKKYYPGEKA
WSVSLKI----FG-KMNLKDLCERAK-EEINWSAQ-TIGPDDAKA-GE------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------TQGDQEAVLGDGTEYRIR-
--------IKEK----------------FCIT--WDKKSLSGKPEDFHHGIA--------
----------------------------------------------EKDRKLLEHLFDVD
VK--TGEQP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

IVVLQGAAGVGKTTLVRKA-----MLDWA--E---------GNLYQ
Q--------RFKY-VFYLNGREINQLK-------ERSFAQ-LISK-DW-----PS-TEGP
IEEIIS-QP----SSLLFIIDSFDE-LNFAFEEP------EF-A-----LCEDWTQE-HP
-VSFLMSSLLRKVMLPEASLLVT-TRLTTSKRLKQLL-K----N-HH--YEELLGMSEDA
RQEYI----------------Y--QF-FED---------KRWAMKVFSSLKS-NEMLFSM
CQVPLVCWATCTCLKQQMEKGG-DV-T--LT-CQTTTALFTCYISSLFTPV-DGGSPSLP
------------NQAQLRRLCQVA---AKGI-WT-MT----YVFYRE-------------
--NLRRLGLTKS-DVSSFMDS----NIIQKDAE-YE-NCYVFTHLHVQEFFAAMFYMLK-
GNWEA--------------GNPS--CQPFEDLK-SLLQSTSYK--DPHLTQMKCFL----
----FGLLNEDRVKQLERTFNCK---------------M--SLK-IKS-KLLQCMEVLGN
SD-----------------------------------YSPSQLGFLELFHCLYETQD-KA
FISQAMRC---------------------F-------------------PKVAINICEKI
HL---LVS--S----FCLK-HCRC-LRT-IRLS----------------VTV-----VFE
--K--KIL----KTSL-----PT--N------------------------TW---DGDRI
THCWQDLC-SVLHTNEHLRELDLCHSNLDKS---------AMNILH--HELRHP------
NC--K-LQKLLLKF---------ITF-PDGCQDISTSL----------------I

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1642)

HNKNL
MHLD-LKGS-DIGDN-GVKSLCEALKHPECK----LQTL--------RLE---------S
CN----------------------------------------------------------
---------LT---VF-CCL---NISNALIR-SQSLIFLNLSTNNLLD-DGVQLLCEA--
LRH-PKCYLERL-S----------------------------------------------
------------------------LESCGLT-----------------------------
----------------------------EAGCEYLSL-----------------------
--------------------------------ALI

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2052)

SNKRLTH---LC-LADNV-LGD---
-------GGVKLMSDAL----QHAQC----------------------------------
--------------------------TLK-SLV---------------------------
-------------------------------LRRCHFTSLSSEYLSTS-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

HNKSLTHLD
L-GSNWLQDNGVK-LLCDVFRHP--SCN----L---------------------------
-----------------------QDLEL--MGC-----VLTNACCLDL------------
-------ASVI-L

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2374)

NNPNLRSLDLGNNDLQDDGVKI-LCDALR-YP-NC-NIQRLG--LE-
--Y-CGLTSLCCQ--------------------DLSSALVCNKRL-IKMNLTQNTLGYEG
IVKLYK--------VLKSPKCK--LQ--V-------------------------------
---LGLCKE-AFDEEAQKL------LE----------AVG-VSNPHLIIKPDCNYHN---
--E---------------------------------------------------------
--------------------------------------------------EDVSWWRCF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------KKDKFRMLL-
---------KKT----------------YWHI--WQI-----------------------
-----------------------------------------------WRYKMQIPFCDPR
AL--SGMLP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

YTVVLQGPSGVGKTTLAKAV-----LLDWI--Q---------DSLAM
---------KFEY-AFYLSCEELNRMG-------PCTFAD-LITK-DF-----PE-LRDA
MPDDLD-RS----HNTLIIVDGFNE-LRA-PG------VLIS-G-----ICANWKVK-KP
-VPILLSSLLSRNLLPRATLLIT-MQTWAWNRLRYLV-E-----RPF--FVDMEGLSEVE
RKEYF----------------L--QH-FQD---------EDQALQAFNLMRS-NEALFRM
GSSPVVCWVVSTCLKLQMEKGE-DP-T--PT-CETITSLFLRFICSQFTSA-------WQ
------------LQAPVKSLCLLA---AEGV-WT-QI----TVFDEE-------------
--DLKRLEINDC-ELSPFLDK----NILQKSKD-RA-GYYSFIHLSVQQFFAAMFYVLR-
TKEEE-------------VQGIP--KGDIGDIQ-QLFSKEETL-KNPSLIEVGYFL----
----FGLANEKRVRELETTFGCP---------------VTRSVE-VKQ-EIVRWKVNTSG
RK-----------------------------------RPLLPMAMKEVVDCLCESQE-ED
FVKDAVVH---------------------F-------------------KEVSLKLKNEK
DL---VQV--S----FCLK-HCQN-LQK-LSLK----------------IDKG----IFL
-ENN-A-M----EV--------------------D------------TQDERSQKD-QHI
LPFWMDLC-SLFGSNKNPIFLEINRSFLSDS---------SVRILC--DQIAS-T-----
TH--S-LQNVV--L-DNIVPA--SA----YQ-DLCLTF----------------SGHESL
THLT-LQSI-GQND--VFPPLCEVLRHPKCN----LQYL--------RLG---------S
C------S----------------------------------------------------
---------AT---TQ-QWD---GLFSVLTI-NQSLTCLNLSASELLD-EGLKLLCRA--
LKH-PQCSLQRL-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EASCKDLSS-----------------------
--------------------------------ALIINQ

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2057)

KLTH---LS-LAKNK-LGD---
-------GGLQLLCEGL----SYPDC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LWECDITDNGCSLLSKL-LQQKSSLTHLD
L-ELNYIGVTGLH-FLCEVLKDP--TCN----L---------------------------
-----------------------KHLVL--CV----------------------------
IPFSCMDFSVL-RCNQNLSTLDLDQ---NPL-------------------GYSRM--LK-
--V-DKSDTEMQK--------------------LVQEIKGSNPQVAIERHHL------KL
---------------NRSSSYD--FL----------------------------------
----P-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
--------------------------------------------------RR--------
-------QSLGAKPRSPLHASPPRECSLEQRGLVGAADRRAPRGRVGWEAGQGRGPRNHM
RVDRHRPPAPSTEAR--AAKA

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 328)

RDL---LQAALEDLS--Q---EQLKRFRHKLRD------
------------AALDG-----------RSI-PWGR-LERAD-AVDLAEQMIQFYGPEPA
LDVARKT----LK-RADVRDVAARLK-EQGLQW---------F---------SPG-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SS-ALLSVSEYKKKYREH-
--------VLQQ----------------HAKV--KERNARS------------VKINKRF
TKLLIARESAALVDE--APGLAE-------EPEP--------ERARRSDTHTFNRLFGRD
E---EGQRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--V---------GKLYH
D--------QVDF-AFFLPCRELLERPG------PCSLAR-LVLD-QC-----PH-RSAP
VRQMLA-RS----ERLLFILDGADE-LP-PGPA--------DAA-----PCTDPFEE-AD
-GARVLDGLMSKTLLPGARLLVT-ARATAPGRLQGRL-C-----SPQ--CAEVRGFSDKD
KKKYF----------------H--KF-FRD---------ERMAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLRQQLQLHQ-DL-S--RT-SKTTTSVYLLFITSVLSSAPATDGP---
-----------QMQEELRKLGRLA---REGTLRH--R----AQFPEK-------------
--DLERLELRGSKVQTLFLSKKELPGVLET-----E-VTYQFMDQSFQEFFAALSYLLE-
QEKAL-------------------E-APADSVG-ALLQGGTEL--RGHLTLTTRFL----
----FGLLNGERLRDIERHFGCG---------------GVVSKR-VKQ-DVLRWVQEQGQ
GHPRAAPEGTEETEAPEGSQEPEE------------EEEGELSYPLELLYCLYETQE-ST
FVHQALRG---------------------W-------------------PELLLERVHFS
RL-DLLVL--S----YCVR-SCPA-GQA-LRLV------------------SC----VLV
------PP----------------------------------------QEKK-----KKS
----------------------------------------LIKR----------------
------LHGS---L--------------SGS------S-----------------SQATA
RK---SQAS-------PLRTLFEAMTDQHCG----LHSL--------TLC---------R
C-----------------------------------------------------------
--------RLP---DS-ICR---DLSEALRE-APALRELGLLHNRLS-EAGLRVLSEG--
-LAWPQCRVQKL------------------------------------------------
----------------------------RVW-----------------------------
---------------QPRL---------QEAFQYL-------------------------
------------------------------TSVLRQSPALTI---LE-LGDC-QLSEPTV
--T--------DLCAVL----QHPGCRLQTLRL--TSVQLSEQ-----------------
----------SLKELQVVKTAKP-------DLV----------------------I--TH
PALD-------------------GHPRPPAGHSSAL------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MLRT----AGRDGLCR

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LSTYLEELE--A---VELKKFKLYLGT------
---------A--TELGE--------G---KI-PWGR-MEKAG-PLEMAQLLITHFGPEEA
WRLALST----FE-RINRKDLW

ENSGT00900000140813_0_Linker_0_1 (323, 536)

ERGQ-REDLVRDT----P--PG--------GPSSL---
------------------------------------------------------GN----
------------------------------------------------------------
---QS-TCLL-------------------------------EVSLVTPRKDPQET

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 658)

YRDY-
--------VRRK----------------FRLM--EDRNARLGECV---------NLSHRY
TRLLLVKEHSNPMQAQQQLL------DRGRGHARTVG--------HQASPIKIETLFEPD
EE--RPEPP----RTVVMQGAAGIGKSMLAHKV-----MLDWA--D---------GKLFQ
G--------RFDY-LFYINCREMNQSAT------ECSMQD-LISG-CW-----PE-PSAP
LQELIR-VP----ERLLFIIDGFDE-LKPSFHDA------QG-P-----WCLCWEEK-RP
-TELLLNSLIRKKLLPELSLLIT-TRPTALEKLHRLL-E-----HPR--HVEILGFSEAE
RKEYF----------------Y--KY-FHN---------AEQAGQVFNYLRD-NEPLFTM
CFVPLVCWVVCTCLQQQLEGGG-LL-R--QT-SRTTTAVYMLYLLSLMQPKPGA-PRL--
-----------QPPPNQRGLCSLA---ADGI-WN-QK----ILFEEQ-------------
--DLRKHGLDGE-DVSAFLNM----NIFQKDIN-CE-RYYSFIHLSFQEFFAAMYYILD-
E--GE--------------R--G--AGPDQDVT-RLLTEYAFS-ERSFLALTSRFL----
----FGLLNEETRSHLEKSLCWK---------------V--SPH-IKM-DLLQWIQSKAQ
SD-----------------------------------GSTLQQGSLEFFSCLYEIQK-EE
FIQQALSH---------------------F-------------------QVIVVSNIA-S
KM-EHMVS--S----FCLK-HCRS-AQV-LHLY----------------GA------TYS
-ADGEDRA--R-CS---------------------------------------AGT---H
TL------------------------L-------------------------V-------
QL--R--------PERTVLLD-------AYSEHLAAAL----------------CTNPNL
IELS-LYRN-ALGSR-GVKLLCQGLRHPNCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------RIS---SS-ACE---DLSAALIA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NKNLTRMDLSGNGVGF-PGMMLLCEG--
LRH-PQCRLQMIQ-----------------------------------------------
------------------------LRKCQLE-----------------------------
----------------------------SGACQEMAS-----------------------
--------------------------------VLG

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

TNPHLVE---LD-LTGNA-LED---
-------LGLRLLCQGL----RHPVC----------------------------------
--------------------------RLR-TLW---------------------------
-------------------------------LG---------------------------
------------------------------------------------------------
-------------------------------IC-----RLGSAACEGL------------
-------SVVL-QA

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2373)

NHNLRELDLSFNDLGDWGLWL-LAEGLQ-HP-AC-RLQKLW--LD-
--S-CGLTAKACK--------------------NLYFTLGI

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NQTL-TDLYLTNNALGDTG
VRLLCK--------RLSHPGCK--LR--V-------------------------------
---LWLFGM-DLNKMTHSR------LA----------ALR-VTKPYLDIGC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------M-SDVNPPSD------------T-PVSFSSS-------------C-T
H---SSCNPPWTFSCYPGSPCENG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

VMLYMRYVS--K---EELQWFKQLLLN------
---------E--F-RTG--------T--MPI-TWDQ-VKTAS-WAEVVHLLIERFPGRRA
WDVTSNI----FA-MMNRENMCAVVH-REINAILP-TLEPEDLNVG------E-------
------------------------------------------------------------
------------------------------------------------------------
-------TQV-------------------------------NLEEGES--GKIQQYKLN-
--------VIDK----------------YFPT--WNFMTWPGNQRDFFYQDV--------
----------------------------------------------HRHMEYLPCLLLPK
RP--QGRQP----K

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 929)

TVVIQGVPGIGKTTLAKRV-----MLEWA--S---------NRFYT
H--------KLWC-AFYFHCQEMNQTT-------EHSFAE-LIEH-KW-----PG-SQDL
VAKIMS-KP----DQLLLLLDGFEE-LTSTLI------NRPE-D-----LSEDWRQK-LP
-GSVLLSSLLSKRMLPEATLLIM-IRCASWPTCKPLL-K-----CPS--LVTLPGFNTME
KIKYF----------------Q--MY-FGH---------RE-KDRVLSFAME-NTILFSM
CQVPVVCWMVCSGLKQQMERGN-NL-T--QA-CPNATSVFIRYISSLFPTRT-ENFSRKI
------------HQAQLEGLCHLA---ADSM-WH-RK----WVFGKE-------------
--DLEEAKLDQT-GVAAFLSM----SVLRRIAG-EE-DRYAFTLLIFQEFFAALFYVLC-
FPQRL--------------KNFH--VLSHVNIQ-RLIASPR-G-SKSYLSHMGLFL----
----FGFLNGTCASAVEQSFGCK---------------V--SFN-NKR-KLLKVIPRLQK
CE-----------------------------------PPSPCSGVPQLFYCLHEIRE-EA
FVSQALNN---------------------Y-------------------RKVVLTIGNNK
DV---QVS--A----FCLK-RCEH-LQE-VELT----------------VTL-----NFK
-NVWKLSS----G-------------------------------SHPGS--EAPES-KGL
HCWWQDLC-SVFATNDKLEVLTVTNSVLEPP---------FLKALA--AALKH-P-----
QC--K-LQKLL--L-RRVNST--ML---N-Q-DLIGVL----------------TGNQHL
RYLE-IQRV-EVDSN-AVKLLCRALRSPRCH----LQCL--------RLE---------D
C------L----------------------------------------------------
---------AT---PR-IWM---DLGSNLQV-NKHLKTLILTKISLEN-YGAYY------
--P-SVAQMERL-S----------------------------------------------
------------------------IENCNIT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QLSCESLAFC-LRK

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2236)

SKTLTHLS
L-AENALKDEGAK-HIWNALSHL--RCP----L---------------------------
-----------------------QRLVL--RKC-----DLTFSCCQDM------------
-------ISAL-C

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNKTLKSLDLSFNSLRDDGVIL-LCEALK-NP-DC-TLQILE--LE-
--N-CLFTSICCQ--------------------AMASMLC

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2462)

KNQHL-RYLDLSKNVIEVDG
ILTLRE--------ALSSQKKR--KE--V-------------------------------
---I------FGY-AGKTG------GP----------CSG--------KRHPEDNTG---
--LEF-------------------------------------------------------
-------------------------------------------LALW-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------M-SDVNPPSD------------T-PIPFSSS-------------S-T
H---SSHIPPWTFSCYPGSPCENG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

VMLYMRNVS--H---EELQRFKQLLLT------
---------E--L-STG--------T--MPI-TWDQ-VETAS-WAEVVHLLIERFPGRRA
WDVTSNI----FA-IMNCDKMCVLVR-REINAILP-TLEPEDLNVG------E-------
------------------------------------------------------------
------------------------------------------------------------
-------TQV-------------------------------NLEEGES--GKIRRYKSN-
--------VMEK----------------FFPI--WDFTTWPGNQRDFFYQDV--------
----------------------------------------------HRHEEYLPCLLLPK
RP--QGRQP----K

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 929)

TVVIQGAPGIGKTILAKKV-----MFEWA--R---------NKFYA
H--------KRWC-AFYFHCQEVNQMT-------DQSFSE-LIEQ-KW-----PG-SQDL
VSKIMS-KP----DQLLLLLDGFEE-LTSTLI------DRLE-D-----LSEDWRQK-LP
-GSVLLSSLLSKTMLPEATLLIM-IRFSSWQTCKPLL-K-----CPS--LITLQGFNTME
KIKYF----------------Q--MY-FGH---------TEEGDRVLSFAME-NTILFSM
CRVPVVCWMVCSGLKQQMERGN-NL-T--QA-CPNATSVFVRYISSLFPTRA-ENFSRKI
------------HQAQLEGLCHLA---ADSM-WH-RK----WVLGKE-------------
--DLEEAKLDQT-GVTAFLGM----SILRRIAG-EE-DHYVFTLVTFQEFFAALFYVLC-
FPQRL--------------KNFH--VLSHVNIQ-RLIASPR-G-SKSYLSHMGLFL----
----FGFLNEACASAVEQSFQCK---------------V--SFG-NKR-KLLKVIPLLHK
CD-----------------------------------PPSPGSGVPQLFYCLHEIRE-EA
FVSQALND---------------------Y-------------------HKVVLRIGNNK
EV---QVS--A----FCLK-RCQY-LHE-VELT----------------VTL-----NFM
-NVWKLSS----S-------------------------------SPPGS--EAPES-NGL
HRWWQDLC-SVFATNDKLEVLTMTNSVLGPP---------FLTALA--ASLRH-P-----
QC--K-LQKLL--L-RRVNST--ML---N-Q-DLIGVL----------------MGNQHL
RYLE-IQHV-EVESK-AVKLLCRALRSPRCR----LQCL--------RLE---------D
C------L----------------------------------------------------
---------AT---PR-IWT---DLGNNLQG-NGHLKTLILRKNSLEN-CGAYY------
--L-SMAQLERL-S----------------------------------------------
------------------------IENCNLT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QLTCESLASC-LRQS

PF13516 // ENSGT00900000140813_0_Domain_13 (2214, 2236)

KMLTHLS
L-AENALKDEGAK-HIWNALPHL--RCP----L---------------------------
-----------------------QRLVL--RKC-----DLTFNCCQDM------------
-------ISAL-C

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNKTLKSLDLSFNSLKDDGVIL-LCEALK-NP-DC-TLQILE--LE-
--N-CLFTSICCQ--------------------AMASMLR

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2465)

KNQHL-RHLDLSKNAIGVYG
ILTLCE--------AFSSQKKR--EE--V-------------------------------
---I------FCI-PAWT-----------------------RITSFSPTPHPPDFTG---
--KSD-------------------------------------------------------
-------------------------------------------CLSQI---NPYAVQSSF
SGA---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MTSP----QLEWT---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LQTLLEQLN--E---DELKSFKSLLRA------
---------L--PLEDV--------L--QKA-PWSE-VEEAD-GKKLAEILINTSSENWI
RSATVTV----LE-EMNLTELCK-MA-KSEM-----------------------------
------------------------------------------------------------
--L---------------------------------------------------------
--------------------------------------------------GEKEGRRNS-
---------MQK----------------QSLV--WKNTFWQGDIDSFHDDVI--------
-----------------------------------------------RRHQRFIPFLNPR
TP--GKLTP----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLHGPAGVGKTTLAKKC-----MLDWT--D---------CNLSP
---------TVRY-AFYLSCKELSRMG-------PCSFAE-LISK-DW-----PE-LQDD
IPSILA-QA----QRILFVVDGLDE-LKVPPG------ALIQ-D-----ICGDWTQQ-KP
-VPVLLGSLLKRKMLPKATLLVT-TRPRALRDLQLLV-Q-----QPI--YIRVEGFLESD
RRAYF----------------L--RH-FGD---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DP-A--PT-CLTSTGLFLRFLCSQFPQG-------AQ
------------LWGALRALSLLA---AQGL-WA-QM----SVLHRE-------------
--DLESAGVQES-DLRLFLDR----DILRQDRV-SK-GCYSFIHLSFQQFLTALFYALE-
KE--E---EE--------DRDGH--AWDIGDVQ-KLLSREERL-KNPDLIQVGHFL----
----FGLANEKRVKELEATFGCR---------------M--SPE-IKQ-ELLRCKANLHA
NK-----------------------------------P-LSMTDLKEVLCCLYESQE-EE
LAKVVVAP---------------------L-------------------KKISINLTNTS
EM---MHC--S----FSLK-QCRD-LEK-VSLQ----------------VAKG----VFL
-ENY-VDF----EP--------------------DIEFERC-SYV--TLPSWAQQD-LRS
LRLWTDFC-SLFSSNSNLKFLEVKQSFLSDS---------SVRILC--DHITR-S-----
TC--H-LQKVE--I-KNVSPD--TA----YR-DFCLAF----------------IGKRTL
THLT-LEGH-IEWERTMLLLLCDLLRNHKCN----LQYL--------RLG---------G
H------C----------------------------------------------------
---------AT---SE-QWV---DFFYVLKA-NQSLRHLHLSASVLLD-EGAKLLYKT--
MTH-PKHFLQML-S----------------------------------------------
------------------------L-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QQCSITKRGCRYLSEA-LQEACSLTNLD
L-SLNQIA-RGLW-ILCQALENP--NCN----L---------------------------
-----------------------KHLRL--WSC-----SLMPFYCQHL------------
-------GSAL-ISNQKLETLDLGQNHLWKSGIIQ-LFRVLR-QR-TG-SLKTLR--LK-
--T-YETNLEIKK--------------------LLEEVKEKNPKLTIDCNAS------GA
---------------TAPACCD--FF----------------------------------
----C-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------YCP-----------------GAPSGECARR-EGCFGGLGTGLLQ--
VTSVI-TLFIPS--R--EALAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

ILAALEDLS--Q---EQLKRFRHKLRD------
------------APLDG-----------RSI-PWGR-LENSD-AVDLVDKLTQFYGSEPA
VDVTRKI----LK-KADARDVAVRLK-AQQLQQ---------L---------GPS-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------S-VAVSLSEYKKKYREH-
--------VLLQ----------------HAKV--KERNARS------------VKINKRF
TKLLIAPGSNAVEDE--LLGPSE-------EPEP--------ERARRSDTHTFNKLFRGD
D---EGLRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYH
G--------QVDF-AFFMPCGELLESPG------TRSLAD-LILD-QC-----PD-RKAP
VRQILA-LP----QRLLFILDGADE-LPAVGAP--------EAA-----PCKDPFEA-TS
-GLRVLRGLLSQELLPLARLLVT-TRNVAPGTLRGRL-G-----SPQ--CAEVRGFSDKD
KKKYF----------------F--KF-FRD---------ERKAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLQQQLELGQ-DL-S--RT-SKTTTSVYLLFIASMLKSA-GTNGP---
-----------RVQGELRTLCRLA---REGILKH--Q----AQFSEN-------------
--DLAQLKLQGSQVQTLFLSKKEVLGVLEK-----E-VSYQFIDQSFQEFLAALSYLLE-
AEGAP-------------------G-APAGGVK-MLLNSDAEL--RGHLALTTRFL----
----FGLLSAERVRDVERYFGC-----------------VVPER-VKQ-DTLRWVQGQGH
PK--VAPVGPEKNDELEDTEEPEE-------------DEEDLNFGLELLYCLYETQE-DA
FVRQSLTN---------------------L-------------------PEIVLERVRFT
RM-DLEVL--G----YCAQ-CCPA-GQA-LKLV------------------NC----GLV
------EV----------------------------------------KEK--K---KKS
----------------------------------------LMKR----------------
------LKGS----------------------------------------------QNTT
KQ---PPVS-------LLRPLCEAMTSQQCG----LRIL--------IFS---------R
C-----------------------------------------------------------
--------KLP---DA-VCR---DLSEALKV-APALRELGLLQCRLT-EAGLRLLSDG--
-LVWPTCQVQTL------------------------------------------------
----------------------------RMQ-----------------------------
---------------MPNL---------QEAIQYL-------------------------
------------------------------AILLQQSRVLTT---LD-LSGC-QLPNYMV
--S--------CLCSAL----KHPNCCLKTLSLT--SVELSDM-----------------
----------SLRDLQAVKTSKP-------DLT----------------------I--LH
PKL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------NVQ-TQELQGPTQE------DVEMLEAA
----AGNMQT--------------------------------------------------
--------QGCQDPNQEEPEELEEETGNV----------QVQGCQDLNQ-----------
------EEPE-------------------------------MLEEA----DHRRKYREK-
--------MKAK----------------LLET--WDNIDWPKDHVYIRNTSE--------
----------------------------------------------G-EHEELQRLLDPK
R---TRTQA----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TIVLVGRAGVGKTTLAMQA-----MLHWA--N---------GVLFQ
E--------RFSY-VFFLSCHKIRYMK-------ETSFAE-LISL-DW-----PD-SDAP
IEEFMS-QP----EKLLFIIDDFEE-IIISEPSS--ESLNDG-S-----PCTDWYQE-LP
-VTKILLSLVKKELVPLATLLIT-IKTCFVIDLKPSL-V-----NPC--FVQITGFTGED
LWVYF----------------M--RH-FED---------SREVEKILQQIRK-NENLFHS
CSAPMVCWTVCSCLKQSKVRYY-DL-Q--SI-TQTTTSLYAYFFSNLFSTAE-VDLADES
------------WPGQWRALCNLA---MEGL-WS-MN----FTFDRE-------------
--DTELEGLEVP-FIDCLYKF----NIIQKGND-CR-GCITFTHLSFQEFFAAMSFVLE-
EPREL--------------L-PH--STKPQEMK-ILLRDVLLN-KEAYWTPVVLFF----
----FGLLKKNLARELEDTLHCK---------------M--SPR-VME-ELLKWGEELGK
AK-----------------------------------SASLQFHILQLFHCLHESQE-ED
LAKKMLGH---------------------I-------------------FEVDLNIPGDE
EL---QVS--S----FCLK-HCKR-LDK-LRLS----------------VSS-----HIL
-ERDLEIL----ET--------------------------------------S-EV-DSR
MHAWNSIC-STLVTNENLHELDLSNSKLHAS---------SVKGLC--LALKN-P-----
RC--K-VQKLT--C-KSVTPE--WV---L-Q-DLILVL----------------QG

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1633)

NSKL
THLN-FSSN-KLGAT-V-PLILKALKHSACN----LKYL--------CL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------EKCSLS-----------------------------
----------------------------AASCQDLAL-----------------------
--------------------------------FLTSI

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

QHVTR---LC-LGFNQ-LQD---
-------DGIKLLCAAL----THPKC----------------------------------
--------------------------ALE-RLE---------------------------
-------------------------------LWFCQLGAPSCRYLSDA-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

QNRSLAHLN
L-SKNRLGDEGVK-FL

ENSGT00900000140813_0_Linker_13_14 (2237, 2247)

CEALGRP--D

PF13516 // ENSGT00900000140813_0_Domain_14 (2247, 2348)

CN----L---------------------------
-----------------------QSLNL--SGC-----SFTREGCREL------------
-------

ENSGT00900000140813_0_Linker_14_15 (2348, 2354)

AIAL-K

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNHNVKILDLGQNDLQDEGVKL-LCEALK-PS-HR-ALHTLG--LA-
--K-CNVTTACCQ--------------------HLSSVLSSSKSL-VNLNLLGNELDHDG
VKMLCK--------ALRKSTCR--LQ--K-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MALARA-NSPQEA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALNDLE--E---NSFKTLKFHLRD------
---------V--T------------Q--FHL-ARGE-LESLS-QVDLASKLISMYGAQEA
VRVVSRS----LL-AMNLMELVDYLN-QVC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LN--DYREIYREH-
--------VGC-----------------LE------ER---QDW----------GVNSSH
NKLLLMA-TSSSGGRRSPSC------SD-------LQ-----Q-ELDPV--DVETLFAPE
AE--SYSTP----PI

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 930)

VVMQGSAGTGKTTLVKKL-----VQDWS--K---------GKLYP
G--------QFDY-VFYVSCREVVLLPK-------CDLPN-LICW-CC-GD-----DQAP
VTEILR-QP----GRLLFILDGYDE-LQK---------------------------S-SR
-AERVLHILMRRREVP-CSLLIT-TRPPALQSLEPML-G-----ERR--HVLVLGFSEEE
RETYF----------------S--SC-FTD---------KEQLKNALEFVQN-NAVLYKA
CQVPGICWVVCSWLKKKMARGQ-EV-S--ET-PSNSTDIFTAYVSTFLPTDG-NGDSSEL
----------T-RHKILKSLCSLA---AEGM-RH-QR----LLFEEE-------------
--VLRKHGLDGPSLT-AFLNC----IDYREGLG-IK-KFYSFRHISFQEFFYAMSFLVK-
EDQSQQ----------------G--EATHKEVA-KLVDP---E-NHEEVTLSLQFL----
----FDMLKTESTLSLGLKFCFR-----------------IAPS-VRQ-DL-KHFKEQI-
E-------------------------------------AIKYKRSWDLEFSLYDSKI-KK
LTQGIQMK---------------------D-------------------VILNVQHLD-E
KK-SDKKK--S----VLVT-SSFS-----SGKV------------------QS----PFL
--------GN---GKS--T-------------------RKQKK-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ASN----------------GKS---------R
-GAEE-PAP-GVR-NRR-LASR----EK-GHMEMGD---KEDGGV---E-EQED-EEG-Q
T-LKK-DGEMI---DK-MNG----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSLDIHCEQ-LSD-ARWT----------------EL---------
----LPLI-------------------------------QQYQVV------RLDDC-GLT
EGRCQDIS-SALRV

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPSLTELSLRTNELGDA---------GVHLVL--QGLQS-P-----
VC--K-IQKLS--L-QNCCLT--EA---GCG-VLPGVL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LSTL
RELH-LNDN-PLGDA-GLRLL

ENSGT00900000140813_0_Linker_6_7 (1642, 1650)

CEGLLDPQ

PF13516 // ENSGT00900000140813_0_Domain_7 (1650, 1766)

CH----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LT---AA-SCE---PLATVLRA-KPDFKELTVSNNDLQE-AGIQTLCQG--
LKD-SACQLEML-K----------------------------------------------
------------------------LENCGVT-----------------------------
----------------------------AANCKALSA-----------------------
--------------------------------VVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLQE---LD-LGCNK-LGD---
-------EGIAELCPAL----LRASS----------------------------------
--------------------------RLR-TLW---------------------------
-------------------------------LWECDITAEGCKDLCRV-LKA

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

KQSLKELS
L-AENQLGDEGAR-LLCESLLEP--GCQ----L---------------------------
-----------------------ESLWV--KTC-----GLTAACCPYF------------
-------RSVL-A

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

QNKSLLELQISSNQLGDAGVQE-LCQGLS-QP-GA-VLRVLW--LG-
--E-CNVTDSGCD--------------------TLATALLV

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NRSL-RELDLSNNCVGDPG
IQRLVE--------SLRQPGCV--LE--Q-------------------------------
---LVLYDI-YWTEEMEEQ------LR----------TLE-EHKPSLRVIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MS------------------
----------FFVATSADNGTNDG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LLPYLMALD--Q---YQLEEFKLCLEPRTLMDF
WSA----------PQGH--------F--PHI-PWAN-LRAAD-PLNLSFLLDEHFPKGQA
WNVVLGI----FH-TMNLTSLCEKVR-AKMKGNVQ-TQEPQDATQE------DAEMLEAA
----AGNVQTQECQ-----------------------D----------PNQE-AEQLE--
EKAGNGQTQ---------------------------------GCQDPKQ-----------
------EEPE-------------------------------EPEEA----DHRRKYREK-
--------MKAK----------------VLEK--WDDIPWPEDHVYIRSTSE--------
----------------------------------------------D-EHQELQHLLDPH
G---TGAQA----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TIVLVGRAGVGKTTLAMKA-----LLHWA--D---------GVLFQ
Q--------RFSY-VFYLSCHMTRYMK-------ETTFAK-LISR-DW-----PN-SDAP
IEEFVS-QP----EKLLFIVDGYEN-MIAVEPDS--DGLDDG-P-----PCTDWYQE-LP
-VTKILLSLLKKELVPQATLLIT-IKTFYLTDLKGLV-V-----NPC--FVQMTGFTEED
LWVYF----------------M--RH-FDD---------SREVKKILQQIRK-NETLFDS
CSAPMVCWIVCSCLKQPQVRYY-AL-Q--SV-TETTTSLYAHFFTNLFSTAE-VDLADDS
------------WPGQWRALCSLA---IEGL-WP-MA----FTFNTQ-------------
--ATQREGLEVP-FLDYLYQL----NILQKVSD-CG-GCFSFTHPSLQEFFAALSFVLE-
EPEEF--------------L-QH--SAKYEEMK-LLLQDALVN-KEPYWTPVVLFF----
----FGLLNRNIARELEDTLHCK---------------M--SPR-KME-ELLKWREELDK
AE-----------------------------------SASIQFHVLRFFHCLHESQE-ED
FVEKMLDH---------------------T-------------------FEVDLNILRDK
EL---KAS--S----FCLK-QCKR-LNK-LRLS----------------VGS-----HIL
-ERDLDTL----DT--------------------------------------S-MV-SSR
MHAWNSIC-SVLVRNENVRELDLSNSKLHAL---------SVKALC--LALKN-P-----
RC--K-VQKLT--C-KSVTPE--WI---L-K-ELILAL----------------QG

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1633)

NSKL
THLN-LSSN-KLGET-A-PLILKALKHSACK----LKYL--------CLE---------K
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------CNLS-----------------------------
----------------------------GASCQDLAL-----------------------
--------------------------------FLISIRQVTR---LC-LGFNR-LQD---
-------SGIKLLGAAL----THPEC----------------------------------
--------------------------VLE-RLE---------------------------
-------------------------------LWFCQLGARGCRHLSDA-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

QNRTLMHLN
L-SKNCLGDEGVK-FL

ENSGT00900000140813_0_Linker_13_14 (2237, 2247)

CEALRHP--D

PF13516 // ENSGT00900000140813_0_Domain_14 (2247, 2348)

CK----L---------------------------
-----------------------QSLNL--SGC-----SFTREGCQEL------------
-------

ENSGT00900000140813_0_Linker_14_15 (2348, 2354)

ATAL-K

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNHHVKILDVGENDLGDDGVKL-LCEALK-PS-HH-ALYTLG--LA-
--K-CNLTTACCP--------------------PLVSVLRS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SKTL-VNLNLLGNELDPDG
VKKLCK--------ALRKSTCR--LQ--K-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MSLPI--GL
SSSFPSSTMKHFMDHST----LESSFHL--------LSSS---LENLGKMLMSEMHHKE-
--------GREN----------------LYHTESW-------KME---------DFLQNF
THLLLLLKPCPRGWKT---L------NRKSLHETK--------GEEKGHLIEMEDLFNPN
LD--TQEEP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

LVILEGAAGIGKSTLARQV-----RRAWG--K---------GQLYR
D--------RFQH-VFYFNCRELAQCK-------QLSLAE-LIAK-DQ-----AV-SSAP
IRQILS-HP----EKLLFILDGIDE-PAWVLEMQ------NP-E-----FCLHWSQP-QP
-VPMLLGSLLGKSILPGASLLLT-TRITDLRKFIPSL-G-----QPR--WVEVLGFSKSG
RKKYI----------------Y--KY-FTK---------KREAIAAVSLVKS-NPVLSAL
CVVPWVSWLVCTCLKQQMKQGI-DL-S--LT-SQTTTALCLKYLSLTLP--------GH-
-----------SLETQLRRLCSLA---AEGI-FR-KR----TLFSER-------------
--DLQIQGLDND-VITTFLKM----GVLQKQ---PRSLYYSFAHLCLQEFFAAMSCILY-
F------NEN--------TSDHT--EFY-SIVQ-ALKEGYGRH--DLFEAPTMRFL----
----FGLLSEKEMRKIWNIFPCK---------------W--SRE-TML-HLQRYIQK---
------------------------------------EALLHQPYSLGLLHCLYEIQD-KD
FVAEVMNN---------------------YQETRVHTPVDMEH-PEFQTGVMYMVVQTDV
DL---MVV--T----FCIK-FCCR-VKR-LQMN----------------ASGQ-------
------Q-R---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------K------------
------ISKS--------------------------------------------------
-------------------PKIVLSRWTPMT-----------------------------
----------------------------NASWQVLFS-----------------------
--------------------------------MLEFTG

PF13516 // ENSGT00900000140813_0_Domain_11 (2019, 2054)

SLEE---LD-LSGNP-LSN---
-------SALQSLCRTL----RCPGCHLKTLW----------------------------
------------------------------------------------------------
-------------------------------LLNCGL-----------------------
------------------------------------------------------------
----------------------------------------TS------------------
------------------------------------------------------------
---------RHCE--------------------DLTSVLWA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SSSL-TELDLQLNDLGDHG
VRLL

ENSGT00900000140813_0_Linker_17_18 (2465, 2716)

CE--------GLRNPACN--LR--I-------------------------------
---LRLDQD-PLSDQVMME------LR----------ALE-AENPQMLISS-TLNPPVMD
PTKNMDGEEMGDS-----------------LTSFKQQRLQSGH-----------------
-----------------------------------------KHMEPLG-TEDDFWGPTGP
VATEVVDR-ERNLYR

PF13553 // ENSGT00900000140813_0_Domain_18 (2716, 2997)

VQFPVAGSYHCP---NIGLRFVVTRAV-------TIKIEFCAWSQ
YLNETPLLHSHMVAGPLFDIKADQEA-VATVYLPHFVTLQEG--------QVDISLFQVA
HFQEHGMILETPARVEQHYAVLENPSFSPVGVLVRMIPAVGHFIPITSITLIYYPLNLKD
V-TLHLYLIPNDCTIRKAIDEEEMKFWFVRIHKPPPVDSLYIGSRYIVSAS---------
KRLKIIPKELELCYRSPGESQLFSEIHVGHMGSEINLQIRDKKHRNLIWEALVKPG

ENSGT00900000140813_0_Linker_18_19 (2997, 3052)

DLSP
APPVTP-----------------------------------VAHKDAPASL

PF00619 // ENSGT00900000140813_0_Domain_19 (3052, 3133)

HFLDQHREQ
LVARVTSVDPLLDKLH-SLVLSEEEYEAVRAEATTQDKMRKLFSFSRSWTRTCKDQVYQA
LNEIHPHLIMDLLKKSRRVSV---------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--MDA-AGASC-SSV--DAVAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LMATLEELS--Q---EQLKRFRHKLRD------
------------APLDG-----------RSI-PWGR-LERSD-AVDLVDKLIEFYEPVPA
VEMTRQV----LK-RSDIRDVASRLK-QQQLQK---------L---------GPT-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------S-VLLSVSAFKKKYREH-
--------VLRQ----------------HAKV--KERNARS------------VKINKRF
TKLLIAPGTGAVEDE--LLGPLG-------EPEP--------ERARRSDTHTFNRLFRGN
DE--ESSQP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYH
S--------QVDF-AFFMPCGELLERPG------KRSLAD-LVLD-QC-----PD-RAWP
VKRILA-QP----NRLLFILDGADE-LPTLPSS--------EAT-----PCKDPLEA-TS
-GLRVLSGLLSQELLPGARLLVT-TRHAATGRLQGRL-C-----SPQ--CAEIRGFSDKD
KKKYF----------------F--KF-FRD---------ERKAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLQQQLELGR-DL-S--RT-SKTTTSVYLLFITSMLKSA-GTNGP---
-----------RVQGELRTLCRLA---REGILDH-HK----AQFSEE-------------
--DLEKLKLRGSQVQTIFLNKKEIPGVLKT-----E-VTYQFIDQSFQEFLAALSYLLE-
AERTP-------------------G-TPAGGVQ-KLLNSDAEL--RGHLALTTRFL----
----FGLLNTEGLRDIGNHFGC-----------------VVPDH-VKK-DTLRWVQGQSH
PK--GPPVGAKKTAELEDIEDAEEE----------EEEEEDLNFGLELLYCLYETQE-ED
FVRQALSS---------------------L-------------------PEIVLERVRLT
RM-DLEVL--N----YCVQ-CCPD-GQA-LRLV------------------SC----GLV
------AA----------------------------------------KEKKKK---KKS
----------------------------------------LVKR----------------
------LKGS----------------------------------------------QSTK
KQ---PPVS-------LLRPLCETMTTPKCH----LSVL--------ILS---------H
C-----------------------------------------------------------
--------RLP---DA-VCR---DLSEALKV-APALRELGLLQSRLT-NTGLRLLCEG--
-LAWPKCQVKTL------------------------------------------------
----------------------------RMQ-----------------------------
---------------LPDL---------QEVINYL-------------------------
------------------------------VIVLQQSPVLTT---LD-LSGC-QLPGVIV
--E--------PLCAAL----KHPKCSLKTLSLT--SVELSEN-----------------
----------SLRDLQAVKTSKP-------DLS----------------------I--IY
SK----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAVTKA-RNPREA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALSDLE--E---NDFKKLKFYLRD------
---------M--TLSEG--------Q--PPL-ARGE-LEGLI-PVDLAELLISKYGEKEA
VKVVLKG----LR-VMNLLELVDQLS-HVC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LH--DYREIYREH-
--------VRC-----------------LE------EW---QEA----------GVNGRY
NQVLLVA-KSSSENPESPAH------PI-------PE-----Q-ELDSV--MVEALFDSG
EK--SSLAP----S

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

LVVLQGSAGTGKTTLARKM-----VLDWA--T---------GSLYP
G--------RFDY-VFYVSCKEVVLLLE-------SKLEQ-LLFW-CC-GD-----NQAP
VTEILR-QP----ERLLFILDGFDE-LQRPFEEK------LK-K-----RG-----L-SP
-KESLLHLLIRRHTLPTCSLLIT-TRPLALRNLEPLL-K-----QAR--HVHILGFSEEE
RARYF----------------S--SY-FTD---------EKKADSAFDIVQK-NDILYKA
CQVPGICWVVCSWLNGQMERGK-AV-L--ET-PRNSTDIFMAYVSTFLPPVD-DGGCSEF
----------S-RHRVLRSLCSLA---AEGI-QN-QR----FLFEEA-------------
--ELRKHNLDGPRLA-AFLSS----NDYQLGLA-IK-KFYSFHHISFQDFFHAMSYLVK-
EDQSQL----------------G--KESRRGVQ-RLLEAKEQE-GNDEMTLTMQFL----
----LDILKKDSFLNLELKFCFR-----------------ISPC-LAQ-DL-KHFKEQM-
E-------------------------------------SMKHNRTWDLEFSLYEAKI-KN
LVKGIQMN---------------------D-------------------VSFKIKHSN-E
KK-SQSQN--S----FSVK-SSLS-HGP-KEKQ------------------KR----PSV
---HGQKEGK---DNI--A-------------------GTHKE-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AST----------------GKG---------R
-GTEE-TPKNTYI-Y---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAMAKA-RNPREA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALSDLE--E---NDFKKLKFYLRD------
---------M--TLSEG--------Q--PPL-ARGE-LEGLI-PVDLAELLISKYGEKEA
VKVVLKG----LK-VMNLLELVDQLS-HIC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LH--DYREVYREH-
--------VRC-----------------LE------EW---QEA----------GVNGRY
NQVLLVA-KPSSESPESLAC------PI-------PE-----Q-ELDSV--TVEALFDSG
EK--PSLAP----S

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

LVVLQGSAGTGKTTLARKM-----VLDWA--T---------GTLYP
G--------RFDY-VFYVSCKEVVLLLE-------SKLEQ-LLFW-CC-GD-----NQAP
VTEILR-QP----ERLLFILDGFDE-LQRPFEEK------LK-K-----RG-----L-SP
-KESLLHLLIRRHTLPTCSLLIT-TRPLALRNLEPLL-K-----QAR--HVHILGFSEEE
RARYF----------------S--SY-FTD---------EKQADRAFDIVQK-NDTLYKA
CQVPGICWVVCSWLQGQMERGK-VV-L--ET-PRNSTDIFMAYVSTFLPPDD-DGGCSEL
----------S-RHRVLRSLCSLA---AEGI-QH-QR----FLFEEA-------------
--ELRKHNLDGPRLA-AFLSS----NDYQLGLA-IK-KFYSFRHISFQDFFHAMSYLVK-
EDQSRL----------------G--KESRREVQ-RLLEVKEQE-GNDEMTLTMQFL----
----LDISKKDSFSNLELKFCFR-----------------ISPC-LAQ-DL-KHFKEQM-
E-------------------------------------SMKHNRTWDLEFSLYEAKI-KN
LVKGIQMN---------------------N-------------------VSFKIKHSN-E
KK-SQSQN--L----FSVK-SSLS-HGP-KEEQ------------------KC----PSV
---HGQKEGK---DNI--A-------------------GTPKE-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AST----------------GKG---------R
-GTEE-TDEEVR--SPK-NTYI--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------IKIRDLFCPC
PE--TQEEP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RIVILYGVDGIGKSTLARQV-----QKAWE--K---------GQIYQ
D--------HFQH-IFYFSCRELAQSN-------VISLAE-LITK-AQ-----AA-PSAP
LEQVLS-RP----EQLLFILDGIDE-PRWVLQEQ------ST-E-----VCLHWSQP-QE
-VAALLGSLLGKTILPEASFLIT-TRTVDLQKLIPSL-K-----QPR--WVEVLGFSESG
RKEYF----------------Y--NY-FTD---------ESQALRALFLVES-NPAVWTM
CLVPWLSWLVCTCLKQQMESGE-DL-T--LT-TTTATGLCLHYLSQVIP--------AQ-
-----------CLRHQLRGICSLA---AEGI-WQ-GK----SLFSLD-------------
--DLRKHRLDKP-IISAFLKM----RILQKH---PTSLTYSFIHLCFQEFFVAMSCALG-
D------EEE--------RSEHP--NSI-GGVR-RLLDAYERH--VLVRAPTRCFL----
----FGLLSEQVGREMESIFTCQ---------------R--APE-LKQ-ELLQWAKWEAQ
-----------------------------------EMRFPRQPGFLELFHCLYETQD-EE
FVTEVMGH---------------------F-------------------QGSSVYVQTDM
EL---LVF--T----FCIK-FCHH-VES-LQLH----------------EGGQ-------
------PRS-TWRPARVIL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------HWESRI-S----------------------------------------------
-------VPNDDRCFCS-----QKVMQVPVT-----------------------------
----------------------------DACWQLLFS-----------------------
--------------------------------ILKDTGNLKE---LD-LSGNP-LSC---
-------SAVQSLSETL----RCPCCHLETLRLR--K-MT---------VVSVTHN----
--------------------------NLHSDFW---LILPE-------------------
N-----------------DMKAVLTNLIKLGLANCGLTAEGCKDLAFG-LSTSQTLTELE
L-SFNMVTDAGAK-HLCQRLRQQ--SCR----L---------------------------
-----------------------QRLQL--VSC-----GLTF------------------
------------------------------------------------------------
---------SCCQ--------------------DLASMLSTSRSL-KELDLQQNDLGDLG
VRLLCE--------GLRHPACS--LT--L-------------------------------
---L--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MSLD--I----QSLDIQCEE-LSD-ARWA----------------EL---------
----LPLL-------------------------------QQCQVV------RLDDC-GLT
EARCKDIS-SALRV

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALAELNLRSNELGDV---------GVHCVL--QGLQS-P-----
SC--K-IQKLS--L-QNCCLT--GA---GCG-VLSSTL----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LPTL
QELH-LSDN-LLGDA-GLQLLCEGLLDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LS---AA-SCE---PLASVLRA-KPDFKELTVSNNDINE-AGVRVLCQG--
LKD-SPCQLEAL-K----------------------------------------------
------------------------LESCGVT-----------------------------
----------------------------SDNCRDLCG-----------------------
--------------------------------IVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLRE---LA-LGSNR-LGD---
-------VGIAELCPGL----LHPSS----------------------------------
--------------------------RLR-TLW---------------------------
-------------------------------IWECGITAKGCGDLCRV-LRAKE

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-AGNELGDEGAR-LLCETLLEP--GCQ----L---------------------------
-----------------------ESLWV--KSC-----SFTAACCSHF------------
-------SSVL-AQ

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NKFLLELQISNNRLEDAGVRE-LCQGLG-QP-GS-VLRVLW--LA-
--D-CDVSDSSCS--------------------SLAATLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NHSL-RELDLSNNCLGDAG
ILQLVE--------SVRQPGCL--LE--Q-------------------------------
---LVLYDI-YWSEEMEDR------LQ----------ALE-KDKPSLRVIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----XXXXX---------------------------------XXXXXXX-----------
------XXXX-------------------------------XXXXX----XHRRKYREK-
--------MRAT----------------VLEK--WDNNAWPEDHVYIHSTSE--------
----------------------------------------------D-EHQDLQRLLDPD
G---TGAQA----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TIVLTGRAGVGKTTLAMKA-----LLHWA--D---------GVLFQ
Q--------RFSY-VFYLSCCRMRHMK-------ETTFAK-LISR-DW-----PG-SDAP
VEEFLS-QP----EKLLFIVDGCEN-MIAAEPCS--DGPDGG-P-----PCTDWYQE-LP
-VTRILLGLLKKELVPQATLLIT-IETFYLTDLRGLV-V-----NPR--FVHMTGFTDED
LWVYF----------------M--RH-FED---------PSEVRKILQQIRK-NETLFES
CSAPMVCWIVCACLKQPRVRYY-AL-R--SV-TETATALYACFVTNLFSTAE-VDLADDS
------------WPGQWRALCSLA---IEGL-WS-VA----FMFNTQ-------------
--ATQRQGLEAP-FLDYLHQL----NILQKVGD-GG-GCFTFTHPSLQEFFAAMSFMLE-
EPEEF--------------L-QH--SPKYEEMK-LLLQDALID-KEPCWTPVVLFL----
----FGLLNRSIARELESTLRCK---------------V--SPR-KTE-ELLEWWEGLDK
AE-----------------------------------SASVQFHVLRFFLCLHESQE-EG
FVEKMLDR---------------------T-------------------FEVDLHILREE
EL---KAA--S----FCLK-QCKG-LTK-LRLS----------------VGS-----HIL
-ERDVDTL----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MMDSSGYG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 322)

-LLQYLQKLS--D---EEFQKFKERLRK------
---------E--PEKFN--------L--KPI-SWTK-IKNTS-KEDLAMQLYTHYPGK-A
WDMVLSL----FL-QVNRKDLSTMAQ-IERRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------KQTKYKEF-
--------MKNA----------------FQHI--WTTETNTYIPDR--------------
---------------------------------S-------YHEFIEVQYRALQDIFDCE
-----SE-P----V

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVVSGSRGGGKTTFLRKA-----MLDWA--S---------RNLLQ
N--------RFQY-VFYFSVFSLNNIT-------ELSLAE-LISS-TL-----PES-SET
VDDILS-DP----KRILFILDGFDY-LKFDLE-L------RT-N-----LCNDWRKK-LP
-TQIVLSSLLQKIMLPECSLLLE-LGNASLSNIIPLL-Q-----HPR--EIIMSGFSEQT
IEIYC----------------V--SF--FN---------TQTGVEIFENLKS-IKPLFNL
CCCPYLCWMICSTLKWQYERKE-VA-N--HF-GRTLALLYTIFMVSAFKSTY-ARNPSK-
-----------QNRARLRTLCTLA---VEGM-WK-QV----YVFDSD-------------
--DLRRNGISES-DKKVWLRM----KFLQNQG-----SNIVFYHSTLQWYFAVLFYFLQ-
QYKDA-----------------H--HPVIGNIA-QLLGEIYAH-KQNQWFHTRILL----
----FGMATEQVTSLLEPCFGCI---------------S--TKE-VRQ-EIIRYIKSLSQ
QEC----------------------------------NEKLVVHPQNLFFCILDNQE-ER
FVRQLMDL---------------------F-------------------EEMTVDISNVD
DM---SAT--Q----YCLH-RASK-VKN-LHLH----------------IQKR----VFL
-EIHDPEY-----------A-------------------D-L-------ELFK-LNQKLL
VNHWTRLC-TFLC---NLHVLDLDSCHFNEN---------AIEVLC--NCLSPTSSVPLT
GF--K-LHRLLCSF---------MTN-FGD-GLLFSTF----------------LHLPHL
KYMN-LYGT-NLSND-AVERLCSALKFSTCG----VEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GKCDIS-----------------------------
----------------------------SEACGIIAT-----------------------
--------------------------------SLINS-EVKH---LS-LVENP-LKN---
-------KGVMSLCEML----KDPSCALESL-----------------------------
------------------------------------------------------------
------------------------------MLSYCCLTFIACGHLYEA-LLSNERLSLLD
L-GSNFLEDTGVN-LLCEALKVP--NCT----L---------------------------
-----------------------KELWL--PGC-----YLTSECCEEI------------
-------SAVL-TC

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NRNLKTLKLGNNNIQDTGVKR-LCEALC-HP-NC-EMQCLG--LD-
--M-CNFTSDCCE--------------------DLALVLTT

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

CNTL-KSLNLDWNAFDHSG
LEMLCK--------ALNHKACN--LE--V-------------------------------
---LGLDKS-AFSEESQTL------LQ----------AVE-KKNNNLNVLHFPWVEE---
--ERE-----KR------------------------------------------------
--------------------------------------------------GVRPVWNSKN
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MALALT-SN

PF02758 // ENSGT00900000140813_0_Domain_0 (201, 328)

PQEA---LLLALSDLD--E---NDFKILKFHLRD------
---------R--TLLGG-----------QGL-ARGE-LEGLS-RVDLASRLVLRYGAQEA
VKMVCKV----LQ-VMNLLELVDQLS-HIC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LN--DYRETYREY-
--------VRC-----------------LE------ER---QEE----------GVSRTY
NQLLLVA-IASPGSPE-------------------PE-----Q-EQGSV--TVEALFDPG
EM--PTPGP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

ATVVLQGPAGTGKTTLARKI-----VLDWA--T---------GTLYK
D--------RFDY-VFYVGCREVVLLPE-------GTLDQ-LLLW-CC-GD-----SKAP
VTEIRR-QP----ERLLFILDGYDE-LQRPFAKR------LR-R-----PG-----P-SP
-AQDTLRRLIRREVLPTCSLLIT-TRPLALRNLQSLL-R-----QPR--HVQVRGFSEEE
REKYV----------------Q--AY-FTD---------GEQAQKAFDFIRG-NDVLYQA
CLVPGICWVVCSWLKGRMERGG-EV-S--ET-PSSGTDIFMAYVSTFLPPND-NEDPSEL
----------T-RDRVLRGLCSLA---AEGI-QH-QR----FLFEEA-------------
--DLRKHSLDGPSLA-AFLSS----HDYQEGLD-IK-KFYSFRHISFQEFFHAMSYLVK-
EDQSQL----------------G--EESLREVN-RLLGDREQA-AGEEMTLSMQFL----
----LDISKKESSSNLELTFCFK-----------------ISPS-IKQ-DL-KNFKEQM-
S-------------------------------------SLKHNRTWEWDFFLNEAKM-KS
LANCVQMS---------------------N-------------------VAFKVGHSN-E
KK-SHSRS--S----FSVT-TSLS-DAK-KEER------------------KC----LVV
--------NE---RNV--A-------------------GTQKQ-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AAN----------------GKS---------R
-G----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFFSDFV---F

PF02758 // ENSGT00900000140813_0_Domain_0 (209, 323)

MWYLEELN--K---KEFMKFKEVLRK------
---------E--MAESG--------L--QHI-PWTE-VKKAS-REDLANLLVKHYE-KKA
WDVTFRI----FQ-NINRKDLSERAA-GEM------------AG--------------HS
K---------------------------------------------------IYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKV----------------LSQD--CSRKFNIPIQHF--------------
---------------------------------L-------KEEFTPDKCSRLQQLFVPK
TT--EKK-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVLLKGVSGVGKTVLLAEL-----MMAWS--E---------GLMFQ
N--------EFSY-VFYLCCHEIKQLK-------TASLAD-LLSR-EW-----PRP-SAP
IAEIVS-QP----AKLLFIIDSLEG-LNCDLSEP------ES-E-----LCDNWMQK-CP
-VSILLSSLLRRKLLPESSLLIT-ATPEAFEKLGDRI-E-----YTV--KNFVTGFNENS
RRSCF----------------Q--RV-FQD---------EDTAQEVFTLVRE-NEQLYNI
CHVPSLCWMVATCLNDEVKRGG-HL-S--AV-CRCTTSVFAAYVLNLFIPQS-AHYPSK-
-----------KSQALLRGLCSVA---AEGM-WT-DN----FAFNQK-------------
--DLEKNGVFHS-DISTLLNM----KILLKSRD-SK-NLYTFLHPSIQEFCAALFYLVN-
SHVDH-----------------P--SKDVLCVE-TLLFTFLKK-VRVQWIFLGCFI----
----FGLLHKSEQAKLEAFFGYQ---------------L--SQE-VKQ-TLCQSLEKISA
DEE-----------------------------------LRKQIDDMKLFYCLFELED-DG
FVTQVMTF---------------------L-------------------PQIKFVAKEYS
DL---IVA--A----YCLK-NCST-LQK-LSIS----------------TQD-----ILQ
-EEK--DP-----------R-------------------------------------KKL
LLCWQDLC-SVLGSSQQIQVLQVKDTYLNEL---------AFLELH--NHLRNP------
SC--A-PRKFLVNN---------VSF-LCNNQLFFELL----------------TQNHNL
HHLD-LSLT-SLSRS-DVKLLCEVLNQKGCH----IEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ASCSLSKQCWNYLSDV-LKR

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NKTLSHLD
V-SSNDLQDEGLK-VLCQALSLP--DSA----L---------------------------
-----------------------KSLLL--QIT-----EFDKETQELL------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------I----------AEK-EKNPYLTILSS-V------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------LPV----SGRH

PF02758 // ENSGT00900000140813_0_Domain_0 (204, 328)

ILCCLAAYLEELE--S---VELTKFKMYLGL------
---------E--AKREG--------E--GRI-PWGR-MEKAG-PLDMAQILVAHKGPAEA
WELALRV----FF-WINRKDLWERGC-RELLVRXX----X--XX--------XXXXXX--
------------------------------------------------------XX----
------------------------------------------------------------
X-----XXXX-------------------------------XXXXXXXXXXLQETYREH-
--------IRRK----------------YRFI--EDRNARLGELV---------NLSQRY
TRLLLVKEHATLTRAQHELL------ATGKQHALCLD--------QRASPIQIETLFEPD
EE--RPDAP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVVLQGAAGIGKSILAQKV-----MLDWA--E---------GHLYS
G--------RFDY-LFYVNCREMNQV-R------ERSVED-LISV-CW-----PE-RNVP
ISEIVQ-VP----KRLLFIIDGFDE-LRTSFHES------RD-C-----CCIQWNER-KP
-VEDLLSCLLRKKLLPELSLLIT-TRPTTLETLHHLL-E-----QPR--HVKILGFSKVQ
RQEYF----------------Y--KF-FRH---------EEQAQQGFSLVRD-NEQLFTM
CFVPMICWIVCTCLKQQLEAGW-PF-S--QT-SKTTTAVYTFYLLSLLQPKQER-HRT--
-----------QLQPNLRGLCSLA---AAGL-WS-QR----ILFEED-------------
--DLHRHGLKGD-DVSAFLNM----NVFHKDIQ-CE-RYYSFIHLSFQEFFAAMFYVLE-
G---E--------------P--G--A-SPADLT-RLLNHYAKS-ERSYLALTVRFL----
----FGLLNEERRKSLEKQLGWK---------------T--SRR-TKW-DLLQWIQAKAQ
SE-----------------------------------GSTLQRGTLEIFECLYEIQE-ED
FIQRALDH---------------------F-------------------QVVVVSDMA-T
KT-EHVVS--S----FCVR-NCRS-ALV-VHLF----------------SA------MFS
-SDVMEDR--T-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------KN-DLEDL-GIQELCRGLRHPNCK----VQEL--------KLK---------R
C-----------------------------------------------------------
--------QIS---SA-ACQ---DIALALMT-NQNLIRLDLSRNA-GC-PGVKLLCEG--
LQH-PKCHLQMLQ-----------------------------------------------
------------------------LRRCQVD-----------------------------
----------------------------EAACQELSK-----------------------
--------------------------------VLSTSQHLTE---LD-LTGNS-LXX---
-------XXXXXXXXXX----XXXXX----------------------------------
--------------------------XXX-XXX---------------------------
-------------------------------LKICHLTPSACHNLSTV-LSTNQ

PF00560 // ENSGT00900000140813_0_Domain_13 (2215, 2236)

NLTELD
L-SLNDLGDLGVK-SLCEGLCHS--KSQ----L---------------------------
-----------------------QTLRL--GIC-----RLTFVSCEAL------------
-------STTL-QSNI

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2375)

HLKELDVSFNDLEDMGVHL-LCEGLQ-HP-KC-KLHKL------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MTPEDVEMMGD------------
------------------------------------------------------------
----------------------QV------------------------------------
-------PEE-------------------------------EMLSEDKVFDDGADYRTI-
--------IKEK----------------FYIT--WDKSSYFGQSAILNHGIT--------
----------------------------------------------HKDQKLLTRMFE-D
IK--IYTFT----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVILQGAAGIGKTTLLRKA-----MLEWA--D---------GNICQ
---------QYSY-VFYLNGKEVSQSK-------EKSFVE-LISN-NW-----PS-SEGP
IEEILS-EP----RNLLFMIDSFDE-LDFSFEEP------EF-A-----LCSDWNQK-HP
-VSFLISSLLRKVMLPESFLVVT-TRSTAWKRLMPLL-H-----NPR--CVNLPGLSKIS
RMDYI----------------H--HL-LKD---------KTWAMDAICSIRK-NERLFNM
CHVYHMCQVICTCLKEQMEKGG-NI-A--DI-CQTTTALFTYYICSLFSQV-DESCITLP
------------NETLLRSLCQAA---AEGI-WS-MK----YILYKK-------------
--NLRKNELTRD-DLSVFLNV----NVLQEDKE-YE-NCYAFTHFHVQEFFAALFYLLI-
QNPEK--------------RDYP--RKSFEDLY-SLLESNSFH--NPHLEQMKCFM----
----FGLLNKDRVRQLEETFKFT---------------I--SMD-IKV-ELLMCLETLEK
DD-----------------------------------INPSPLTLPDLLPCLYETQD-RD
FITRALNY---------------------F-------------------TRIDVRVEEET
QL---LIY--S----FCLK-YCYS-LET-IKLT----------------AVA-----ELR
-----NLL----DLNP-----TA--E------------------------TCLKDTVARI
MKYWQDLF-SVLHKNECLREMDLYESRLDES---------LMKILN--EELSHT------
RC--K-LQKLLLGS---------VCF-LNSCQD-FRFL----------------T

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1642)

NCHTL
THLD-LKDA-NLEDN-GLRSLCEALQSQKCK----LRVL--------RLE---------S
CA----------------------------------------------------------
---------LN---AI-HCI---KLSDALNR-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SRSLVFLNLSTNNLTD-NGGQSLCKI--
IEN-PNCRLERL-S----------------------------------------------
------------------------LASCGLT-----------------------------
----------------------------EAVCEVLSL-----------------------
--------------------------------ALTKSKRLTH---LC-LANNF-LKD---
-------EGIKLLSDAL----KHPQC----------------------------------
--------------------------TLQ-SLV---------------------------
-------------------------------LRGCDFSQVGSEFLFTA-LK

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

KNRSLIHLD
L-GSNRVQDSGIK-FL

ENSGT00900000140813_0_Linker_13_14 (2237, 2247)

CRALQDP--T

PF13516 // ENSGT00900000140813_0_Domain_14 (2247, 2348)

CT----L---------------------------
-----------------------QELEL--MGC-----VLTSEGCLDL------------
-------ASVI-VNNPNLWSLDLANNNLMDAGLHI-LCEALK-NP-KC-RIQRLG--LE-
--N-CGFSPVCCK--------------------DLLSLFYQNQSL-VQINLMKNALSYDT
IRELCK--------VLKSSRCK--IK--F-------------------------------
---LALNKKDICNKKIKKL------LN----------DLR-MNDSKLVIESYYCN-----
--T---------------------------------------------------------
--------------------------------------------------ESGSWWQYF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MEPSA----QLG

PF02758 // ENSGT00900000140813_0_Domain_0 (203, 326)

FN---LQPLLEQFA--Q---DELSQFKSLLRP------
---------L--SLQDE--------L--QHI-PATE-VEEAD-GKQLAEILINHCPSHWV
EMVTIQI----FD-KMNRTDLSERAK-DELRVKIM-KRSN----HRK------PEETW--
------ITRT---TELK--------------------------C---ANLEEPPEHVE-E
KDSAFT---------------------------------QVQEEDVTNP-----------
-------EEA-------------------------------KEGLKGEKPGKQDKYISI-
--------LKEK----------------VQQM--WKKNFWPGASENIHT-----------
---------------------------------------------VTQKYETLIPFCNPK
ML--AGPFP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVVLHGPAGVGKTTLAKKC-----MLDWT--E---------DSLAQ
---------TCPT-AFYLSCKALSRKG-------MCSFIE-LLAQ-SA-----PD-LQDA
LAQVLT-QA----QKLLFVIDAFEE-LRVPSGVE----ALVH-D-----LCVDWKTQ-RP
-ASTLLGSLLKRKLLPTAALLVT-TRPEALRELRLMV-E-----QPL--FVEIEGLSECD
RKAYF----------------L--RH-FGE---------EAQALRAFHLMKS-NATLFQM
GAAPAVCWMVCTCLKLQMDEGE-DP-G--PT-CQTTTSLLLRFLCSQFAPAQG-SCLGLH
------------LRSTLHALCLLA---TEGV-WT-QT----SVFDGH-------------
--DLLRLGVHES-DLHPFLNR----NILQKSRD-CE-GCYCFLHLSVQQFLAAALYILG-
SQDHQ---DL--------PAGSP--SWDAGNVQ-RLLSKEEGL-KNPYLAPVGHFL----
----FGLTNEKRARELGMTFGCL---------------V--STK-VKQ-ELLECRVGSPE
NR-----------------------------------PFSSVTDTKETLHCLYESQE-EQ
LVKEAMVQ---------------------V-------------------TEVSLVFKDTS
DI---MHA--S----FCLK-HCES-LQK-MWLQ----------------IEKG----MFL
-END-AVS----ES--------------------EDQADR------------SQND-QHV
LPFWIDFC-SMFDSNKNLIFLDISQSFLSAS---------SVRILC--EKITS-A-----
TH--N-LQKVV--L-KNIFPA--DA----YR-NFCIAF----------------GGHETL
THLT-LQGN-DQND--MLPILCEILRHPKCN----LQYL--------RLV---------S
C------S----------------------------------------------------
---------AT---TQ-QWA---HLSSSLKI-NQSLTCLNLTANELPD-ESAKLLCTT--
LRH-PKCFLQRL-S----------------------------------------------
------------------------LENCQLT-----------------------------
----------------------------EACCKELSS-----------------------
--------------------------------ALIV

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2055)

NQRLTH---LS-LAKNT-LGD---
-------DGVKLLCEGL----SYPDC----------------------------------
--------------------------QLQ-MLV---------------------------
-------------------------------LWYCSITSGGCNHLSTL-LQQ

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2238)

NSNLTHLD
L-GLNHIGITGLK-FLCEALKNP--MCN----L---------------------------
-----------------------KCLWL--WGC-----AITPFSSEIL------------
-------SSAL-GR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NQSLVTLDLGQNSLGYSGIKM-LCDTLK-LH-CS-SLRTLR--LK-
--I-DESDPRIQK--------------------LLKEIQEYDPQLTIESDDQ----DPTN
---------------NRPSSHD--FI----------------------------------
----F-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFFSDYG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LMWYLEELN--K---KEFMKFKEFLKE------
---------D--IVQYG--------L--KQI-PWTE-VKKAS-REDLANLLVKYYEEKKA
WDVTFRI----FQ-KINRKDLSERAA-REI------------AG--------------YT
K---------------------------------------------------LYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKK----------------LTRD--WSRKFDFPIQDF--------------
---------------------------------M-------KPKVSQDEYSRFEHLFTSK
TA--ETK-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVLLKGMAGIGKTLTLARL-----MLAWS--D---------GLVFQ
N--------KFSY-IFYFCCREVTQLE-------TASLAE-LMSR-EW-----PSA-SAP
IMEIIS-QP----EKLLFIVDSLER-LNCDFTEP------EL-E-----LCHNWIEK-RP
-VPILLSSLLRRKILPESSLLIT-ATPETFDKLEDRI-D-----YTE--MRAMLGFDESS
RRMIF----------------R--DL-FPD---------KNRAQEAFRLVRE-NEQVFTL
CQVPLLCLAVATCLRNEIDKGR-DP-A--PV-CRRTTSVYTTYILNLLIPKS-AHGPNK-
-----------KSQDLLQGLCSLA---AEGM-WT-DR----FAFSEE-------------
--DLGKNGIVSS-DIPMLLNI----KIFLRSRD-FK-NFYTFLHPSVQEFCAAVFYLVK-
NHTDH-----------------P--SKDVRCIE-TLLFTFLKK-VNVHWIFGGCFI----
----FGLLHKCEQEKLEAFFGYQ---------------L--SQE-VKQ-KLYRCLETVSV
NED-----------------------------------LQEQVDSMRLFYCLFEMDD-EA
FVVQVVNF---------------------L-------------------QQVKFVAKDYS
DL---MVA--A----YCLK-HCST-LKK-LSFS----------------MQA-----VLQ
-LEQ--EH-----------S-----------------------------------YMEKL
LICWQDVC-SALVSSEQVQELQVKDTNLGEL---------AFSVLY--NHLKHP------
SC--T-PQILEVNN---------VSF-LCNNYMFFEML----------------AQNHNL
RYLN-LSFT-VLSHS-DVKLLCEVLNREECI----IEKL--------LV-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------AGCQLS-----------------------------
----------------------------PEDCKIFAS-----------------------
--------------------------------VLTNSKTLDH---LN-IASNS-LE----
-------KGVSSLCKAL----CQPDCVLKCL-----------------------------
------------------------------------------------------------
------------------------------MLANCSLSEQCWDYLSDV-LK

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2233)

QNRTLEHLD
V-SSNDLQDEGLK-ILCKPLSLP--DSV----L---------------------------
-----------------------QTLHL--RHC-----LITASSCQDL------------
-------SEVL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

NNQNLKSLQISNNKIEDAGVKF-LCDAIK-QP-SC-HLEILG--LQ-
--A-CELSDACCE--------------------DLASAFIQSQTL-RAVILAENALSRSG
LAVLCE--------ALQQHRNI--QR--I-------------------------------
---LGLQIT-DFDKETQAF------LL----------AEE-EKNPYMLIVS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MVSPA----PMGFN---LP

PF02758 // ENSGT00900000140813_0_Domain_0 (210, 323)

ALLEQLS--Q---DELSKFKSLITT------
---------V--SLANE--------L--QKI-PHKE-VDKAD-RKQLAEILTSHCHSYWV
EMATIQV----FE-KMHRMDLSESAK-DELREAAL-KSFN----KNK------PLSLG--
------VTRKERPP---------------------------------LDLEEMLERFK-A
EALAFT---------------------------------ET---EEDVT-----------
-------CLT-------------------------------KEVFKGEKPD--NRYRYI-
--------LKTK----------------FREM--WK--SWPGDSKEVQV-----------
---------------------------------------------MAERYKMLIPFSNPR
VL--PGPFS----YTVVLHGPAALGKPR--------------------------------
---------------------------------------------------------WDD

PF05729 // ENSGT00900000140813_0_Domain_2 (781, 930)

IPHILA-QA----QKILFVIDGFDE-LGAPPG------ALIQ-D-----ICGDWEKK-KP
-VPVLLGSLLKRSMLPKAGLLVT-TRSRALRDLRLLA-E-----EPI--YIRVEGFLEED
RRAYF----------------L--RH-FGD---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DL-A--PT-CLTRTELFLRFLCSRFPQ-------GAQ
------------LRGALRKLSLLA---AQGL-WA-QM----SVLHRE-------------
--DLERLGVQES-DLRPFLDG----HILRQDTV-SK-GCYSFIHLSFQQFLAALFYALE-
KEEEE-------------DRDGH--AWDIGDVQ-KLLSGGERL-RNPDLIQAGYYS----
----FGLANERRAKELEATFGCR---------------I--SPD-IKQ-ELLRCDVSCKG
G------------------------------------H-STMTDLKELLGCLYESQE-EE
LVKEVMAQ---------------------F-------------------KEISLHLN-AV
DV---VPS--S----FCVK-HCRN-LQK-MSLQ----------------VIK-----AEL
-PENVTVS----ES--------------------DAEAER------------SQDD-EHV
LPFWTDLC-SIFGSNKDLMGLTINNSFLSAS---------LVRILC--EQIAS-D-----
TC--H-LQRVV--F-KNISPA--DA----LR-NLCLAL----------------RAHKTV
TYLT-LQGN-DQND--MLPTLCEVLRHPECN----LRYL--------GYS---------L
A-----------------------------------------------------------
------------------------------L-SPRLQCHNLGS---------LQPLWD--
YRH-PAVFFRR-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------C-ITPLR-------
-------------THRF----GFSFF----------------------------------
--------------------------LWL-ISR---------------------------
-------------------------------LWNCDITSDGCCDLAKL-LQEKSSLSCLD
L-GLNHIGVIGVK-LLCEALRKP--LCN----L---------------------------
-----------------------KCLWL--WGC-----SIPPFSCEDL------------
-------CSAL-SCNQSLVTLDLGQNPLGSSGVKM-LFETLT-RP-NG-TLQTLR--LK-
--I-DNFNDELDK--------------------LLEEIEENNPQLIIDTEKH----DPWK
---------------KRPSSHD--FM----------------------------------
----I-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

MDQPEDPSSRLRSLRTASPQRAFVKSVPHQRLRLRPWCKAPKLGLTK-RQPGHVTWPGVW
KNRSREGGAGEEGAPQSSGRRWPVSTSPSEGEEHQD------APTRVRGRWR--------
-------AKSGVTPRCPLPPPHG-----SS--LARGSLRPCPRWVLKRQSRGWAGVTRGP
LPDDPRPPVSSTGLR--LAVAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLAALEELS--Q---EQLKRFRHKLRD------
------------VGPDR-----------RSI-PWGR-LERAD-AVDLAEQLAQFYGPEPA
LEVARKT----LK-RADARDVAAQLK-EQRLRR---------L---------GLG-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SA-ALLSVSEYKKKYREH-
--------VLQL----------------HARV--KERNARS------------VKITKRF
TKLLIAPESAAPEEE--TLGPTE-------EPEP--------GRARRSDTHTFNRLFRGD
E---DGRRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYQ
G--------QVDF-AFFMPCGELLERPG------TRSLAD-LILD-QC-----PD-RGAP
VPQMLA-QP----QRLLFILDGADE-LPALEGP--------EAA-----PCTDPFEA-AS
-GARVLGGLLSKALLPTALLLVT-TRAAAPGRLQGRL-C-----SPQ--CAEVRGFSDKD
KKKYF----------------Y--KF-FQD---------ERRAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLRQQLELGR-DL-S--RT-SKTTTSVYLLFIASVLSSAPVADGP---
-----------RVQGDLRNLCRLA---REGVLGR--R----AQFAEK-------------
--QLEQLELRGSKVQTLFLNKKELPGVLET-----E-VTYQFIDQSFQEFLAALSYLLE-
DEGVP-------------------R-TAAGGVG-TLLRGDSQP--HSHLVLTTRFL----
----FGLLSAERMRDIERHFGC-----------------VVSER-VKQ-EALRWVQGQGQ
GCPGVAPEVTEETKGLEDTEEPEE-----------EEEGEEPNYPLELLYCLYETQE-DA
FVRQALCQ---------------------L-------------------PELALQGVRFC
RM-DVAVL--S----YCVR-CCPA-GQA-LRLI------------------SC----RLV
------AA----------------------------------------QEK--K---KKS
----------------------------------------LGKR----------------
------LQAS---L--------------GGS------S-----------------SRGTT
KQ---LPAS-------LLHPLFQTMTDPLCR----LTSL--------TLS---------H
C-----------------------------------------------------------
--------KVP---DA-VCR---DLSEALRA-APALTELGLLHNRLS-EAGLRMLSEG--
-LAWPQCRVQTV------------------------------------------------
----------------------------RVQ-----------------------------
---------------LPSS---------QQGLQYL-------------------------
------------------------------VGMLRQSPALTT---LD-LSGC-QLPAPMV
--T--------YLCAIL----QHQGCGLQTLRL--TSVELSEQ-----------------
----------SLQELQAVKRAKP-------DLV----------------------I--AH
PVLD-------------------GHPESP-KELVSTF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MSVD--M----PCLDIQCAE-LSD-ARWA----------------EL---------
----LPLL----QR---------------------------CQAV------RLNDC-GLT
EAQCTDIS-SALQA

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELNLRSNELGDA---------GVHRVL--QALQS-S-----
SC--K-ILKLS--F-QNCYLT--AA---GCG-VLSGTL----------------RSL

PF13516 // ENSGT00900000140813_0_Domain_6 (1618, 1642)

PTL
QELH-LSDN-PLGDA-GLQLL

ENSGT00900000140813_0_Linker_6_7 (1642, 1650)

CEGFLDPQ

PF13516 // ENSGT00900000140813_0_Domain_7 (1650, 1765)

CH----LEKL--------QLE---------Y
C------R----------------------------------------------------
---------LS---SA-GCE---PLGSAFRA-KPDFKELTVSNNDIDE-AGFCALCQG--
LKD-SPCQLETL-K----------------------------------------------
------------------------LENCGAT-----------------------------
----------------------------SDSCRDLCS-----------------------
--------------------------------ILASKASLWE---PA-LGNNK-LGD---
-------VGVAELCPEL----LHPSS----------------------------------
--------------------------SLK-TLW---------------------------
-------------------------------IWECGLTAKRCRDLCRV-LRAKD

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-AGNKLGDEGAR-LLCESLLEP--GCQ----L---------------------------
-----------------------ESLWL--KSC-----SLTGACCSHF------------
-------SSVL-AQ

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NKFLLEVQIRDNRLGDAGVQE-LCQGLG-QP-GS-VLRSLW--LG-
--D-CDVSDRICG--------------------SLPATRLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NHSL-RELDLSNNCLGDAG
VLQLME--------ILRQPACL--LEQ-Q-------------------------------
---LVLYDI-YWSLEMEME------ME----------MAA-GPGEGEVIPEGHLLSR---
--FLP-----ARLLRPTLPGQ-------PGLEAPLG------------------------
--------------------------------------------------SHPAYPRFEE
KR----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAGG----A-WGR---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 328)

LACYLELLK--K---EELKEFQLLFTS------
---------K--VHSS--------GS--SGE-TPAR-PEKTS-GMEVASYLVAQYGEQRA
WDLALRT----WE-QMGLWSLCTQAQ-EGAG-------YS-PSFPY---SPIEPHLGSPS
QPTSTAVLRPWNRELP-----AECTQGSERRVLRQLPDTSGRRW-REISSSFLYQ--A--
---------LPSSPD-LESPSQESPNAPTSTAVLASWRSPPQPSLAPREQEAPGTQWPLD
ETSGNYYTGIREKEREESEKGR------PPWEAAVGTPPQVH---ASLQPPRHPWEPS--
--------ARES----------------LCSTWSW-------NNE---------DLNQNF
TQLLLLQRPHPRSQKP---L------VKGSWPHDVEE----DVEEDRGRLIEIRDLFGPG
LD--PQ-EP----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

IVILQGAAGIGKSTLARQV-----REAWG--R---------GQLYG
D--------RFQH-VFYFSCRDLAQCK-------VVSLAE-LIGK-DW-----TA-AQAP
IRQILS-RP----ERLLFILDGVDE-PRWVLQEP------SS-E-----LCLHWSQP-QP
-ADALLGSLLGKTILPEASFLIT-ARTTALQNLIPSL-E-----QAR--WVEVLGFSESS
RREYF----------------Y--KY-FTD---------ERQAIRAFGLIKS-NKELWAL
CLVPWVSWLACTCLMEQMKRKE-EL-T--LT-SKTTTTLCLHYLSQALQ--------AQ-
-----------PLGPQLGDVCSLA---AEGI-WQ-KK----TLFSRD-------------
--DLRKHELDGA-IISTLLKM----GILQEH---PIPLSYSFIHLCFQEFFAAMSYALE-
D------KKG--------RGKHA--NCI-IDLE-KLLEAYGTH--GLFGAPTTRFL----
----LGLLSDEGERAMENIFNCR---------------R--SQG-RN---LMQWVPC---
------------------------------------LRPLLQPHSLDFLHCLYETQN-KM
FLTHMMAD---------------------F-------------------QEMGMCVETDM
EL---LVC--T----FCIQ-FCRH-VKK-LQLI----------------EGRQ-------
------H-R---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------P------------
------AWSP--------------------------------------------------
-------------------TGIVLFRWVPVT-----------------------------
----------------------------DAYWEILFS-----------------------
--------------------------------ILKVTR

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2037)

NLKE---LD-LSGNS-LSH---
-------SAVKSLCKTL----RRPRCLLETLR----------------------------
------------------------------------------------------------
-------------------------------LASCGLTAQDCKDLASG-LRGNQNLTVLD
L-SFNVLTDAGAR-HLCQRLSWT--CCT----L---------------------------
-----------------------QRLRM--GFC-----H---------------------
------------------------------------------------------------
------VTSGCCQ--------------------DLASVLSASPFL-MELDLQQNNLGDTG
VRLLCE--------GLRHPACQ--LT--R-------------------------------
---LGLDQT-TLSDEMRQE------LR----------ALE-QKKPQLLIFS-RWKPTGMI
PNEGLGTGETTNS-----------------TSSRKRQRLGSETESSHVAQADFKLL-DWS
NPPAKA--SQS-AGITEGSSPEVEQ-LEPLCLPSPASLGD-QD-TPLG-TDDDFWGPMGP
VATEVVDK-ERSLYR---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAGG----A-WGR---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LACYLELLK--K---EELKKFQLLLTN------
---------K--AHSR--------GS--SGE-TPAQ-PEKMS-GMQVASHLVAQYGEQQA
WDLAIHT----WE-QMGLRSLCTQAQ-EEAG-------HY-PSFPS---SLSEPSLESPN
QPTSTAVLRSWIPEL------QGCTQGSERSILRHLPDTSGHHW-REITSSLLYQ--A--
---------PLSSPD-YGSPSHDSPNVPTSTAELGSWESPLHPSPVPREQEAPGTQWPLD
ETLGNYYTGETLLGSW-----W------GGRVGEANAGTKNP---LGTS-QCSVWLGSL-
--------WRGS----------------PCSTWSW-------KNE---------DLNQKF
TQLLLLQRPHPRSHEC---L------VRGRLLHNV--------EEDQGHLIEIGDLFGPG
LD--TQ-EP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RVVILQGAAGIGKSTLARWV-----REAWG--R---------GQLYR
D--------CFQH-VFYFSCRELAQSK-------VLSLAE-LIGK-DW-----TA-TQAP
IRQILS-RP----ERLLFILDGVDE-PKWVLEEQ------SP-E-----LCLHWSQP-QP
-ADALLGSLLGKSILPKASFLIT-ARTTALQSLIPSL-E-----QAR--WVEVLGFSESS
RKEYF----------------Y--KY-FTN---------ERQASRAVRLVKS-NKELWAL
CLVPWVSWLACTCLMQQMKQKE-EL-T--LT-SKTTTTLCLHYFSQTLQ--------AQ-
-----------PLGSQLRGFCSLA---AEGI-WQ-RK----TLFSPD-------------
--DLKKHGLDGA-IISSLLKM----GILQEH---PIPLSYSFIHLCFQEFFAGMSCALE-
D------KKE--------GSEHS--NHI-MGLG-KLLETYGTH--DLFRAPTTRFL----
----LGLLSEQGAREMENIFDCR---------------L--SQE-RKR-RLLQCTQF---
------------------------------------LQPPLQSYPLEFLHCLYETQG-KR
FLTQMMAH---------------------F-------------------QEVCMCVETDM
EL---LVC--T----FCIK-FCHN-VKK-LQLI----------------EGRQ-------
------H-G---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------P------------
------AWSL--------------------------------------------------
-------------------DRVVLFRWVPAT-----------------------------
----------------------------DAYWQILFS-----------------------
--------------------------------VLKVTGSLKE---LD-LSGNL-LSL---
-------SAVQSLCETL----RYPRCL

PF13516 // ENSGT00900000140813_0_Domain_12 (2068, 2206)

LETLR----------------------------
------------------------------------------------------------
-------------------------------LAGCGLTAEGCKDL

ENSGT00900000140813_0_Linker_12_13 (2206, 2212)

ASG-LR

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

TNQTLTEVE
L-SFNVLTDAGAK-HLCQGLRRP--SCK----L---------------------------
-----------------------QRLQL--VSC-----GLTS------------------
------------------------------------------------------------
---------GCCR--------------------ALASVLSA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

SPSL-KELDLQQNDLDDVG
VQL

ENSGT00900000140813_0_Linker_17_18 (2464, 2716)

LFK--------GLRHPTCK--LT--R-------------------------------
---LGLDQT-TLSDETRQE------LR----------ALV-QEKPRIQFFCMRRKPSVMI
PNEGPDTGEMSNS-----------------TSSLKRQRLRSETESSYVAQADLKPL-DWS
NPPAK------------GSVPRIAQ-QELACLPSPASQED-LHTKPLG-TDDDFWGPTGP
VATEVVDK-ERSLYR

PF13553 // ENSGT00900000140813_0_Domain_18 (2716, 2997)

VHFPMAGTYRWP---NMGLCFVVREAV-------TTEIELCVWDK
LLGEINQQHSWMVAGPLLDIKAEPGA-IKAVHLPHFVALQGG--------HIDTSLFQVA
HFKEEGMLLEKPAKVELHHIVLEDPSFSPMGVLLRVIHNALRIFPVTSMVLLYHRIHPEE
V-TFHLYLIPSDGSIRKAVDDEETKFQFVRLHKPPPLTPLYMGSRYAVSGSEE-------
--LEIIPEELELCYRSPGEPQLFSEFYVGHLGSGIRLQMKNKTDETLVWEALVKPG

ENSGT00900000140813_0_Linker_18_19 (2997, 3052)

DLTP
ATTLVPP-----------------------------APKALPSPLDALGLL

PF00619 // ENSGT00900000140813_0_Domain_19 (3052, 3134)

HFVDQYREQ
LVARVTSVEPVLDNLL-GHVLSQEQYEGVLAEDTRPSKMRKLFSFSQSWDRSCKDRLYQA
LKETHPYLIMELWEKGSKKGLLPLSI----------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MS------------------
----------SSAGISMDDTFLDK---F

PF02758 // ENSGT00900000140813_0_Domain_0 (209, 323)

MSYLKGLD--Q---YQLEEFKLCLQSPQLM--
--------------PEN--------F--PKI-PWTN-LKAVG-PSNLFCLLSDYLSVPQI
RDVTLCI----FE-NMKLMSRCEEIR-AEMNGEWD-AAWN--------------------
---------------------------------------------------SW-------
---------DCFHPGHLTSHHRCLVSEST----------QALGLQDPGQ-----------
------EEPE-------------------------------VPEEET---AHRRKYRER-
--------MKDK----------------ILLM--WDSIPWPEGHIYLRHMTE--------
----------------------------------------------Q-EHEELRSLLYPN
R---TGAQP----E

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TIILGGRAGVGKTILAMKV-----MLHWA--E---------GSLFQ
H--------RFSY-VFYISCHKLQRMR-------NTTFVG-LLSQ-DW-----PD-SQIP
LTELIN-HS----ERLLFIVDGFEE-SAVSST------LERS-P-----PCSDWYTP-LP
-GDRLILHLLKKELVPQATLLIT-ARDTQIAYLKKLL-P-----NPH--FIFISGFTEED
RGEYF----------------I--RF-FGD---------QDKANAILRWLRQ-NETLFDW
CSAPLVCWTVCSSLMWQMTRNP-SF-E--MS-TQTVTSIYAYFFSQLFTTAE-VNLSDQS
------------WPEQWRALCSLA---AEGM-WC-LN----SVFAKE-------------
--VLEHCHLEAS-FIDYLLRL----NILQKVID-CE-GCIAFTHQSFQMFFGAMFYLLR-
GTEGS--------------V-GG--LPKFDEIK-VFINGVFTD-TNLYWHQIALFL----
----FGLFKRDLARELEVSLHCE---------------M--SPR-VIY-ALLDWTEALAV
DD-----------------------------------PAYIHFEFLQFFQCLCEMQD-EN
LVQKVLNR---------------------L-------------------LEADIDIDKNE
GL---HAS--S----LCLK-HCPK-LTR-LRLS----------------ISS-----PIP
-QV------------------------------------------------QTRVV-DFK
MHQWQDIC-S-VFCNGHMRELDLSNSKLNTL---------YMKKLC--HELGS-S-----
RC--K-LQKLT--C-KSMSPV--RI---L-K-ELVLVL----------------HC

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1633)

NPNL
THLD-LSSN-NLGIT-VSMMIFRTLRHPSCS----L------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------K----------------------------------------------
------------------------LEKCSLP-----------------------------
----------------------------VASCRDLAL-----------------------
--------------------------------LLISTH

PF13516 // ENSGT00900000140813_0_Domain_11 (2019, 2054)

RMTR---LC-LGFNQ-IQD---
-------AGVKLLCASL----AHPKC----------------------------------
--------------------------LLE-RLV---------------------------
-------------------------------LWFCQLSAASCRYLSNA-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

QNKRLTHLN
L-RKNNLGDEGVK-FL

ENSGT00900000140813_0_Linker_13_14 (2237, 2247)

CEPLRCP--D

PF13516 // ENSGT00900000140813_0_Domain_14 (2247, 2348)

CN----L---------------------------
-----------------------QDLNL--SDC-----SFSVEGCREL------------
-------

ENSGT00900000140813_0_Linker_14_15 (2348, 2354)

ADAL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNQSLKILDLGENDVRDNGAKE-LCEVLK-HV-NY-ALKTLG--LE-
--K-CNLTHNCCQ--------------------HLCSVLR

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2461)

NNRSL-VHLNLLGNDLGPDG
VNRLWT--------SLKKSTCQ--LQ--K-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------LSLGIKEKYHNQ-
--------RRES----------------SCPTQSW-------RNE---------YLHQKF
TQLLLLHRSQPRGYDF---L------HWRKRYHEV--------VDEQGQLMEIGDLFGPG
LS--TQEEP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

PTVVVHGVAGIGKSTLARQV-----RRAWE--E---------GWLFK
D--------RFKH-VFYFNCRELAQSE-------TMSLAE-LITK-DW-----AA-PDAP
IGQILS-QP----EQLLFILDNLDE-PKWDLKEQ------SS-E-----LCPHWSQQ-QQ
-VHTLLGSLLKKTLLPTASLLIT-ARITALGKLIPSL-K-----HPH--WVEILGFSESA
RKEYF----------------Y--KY-FTD---------ESQAIRAFTLVES-NPALFTM
CLMPLVSWLVCTCLKQQMEQEQ-PL-S--LT-SQTTTALCLHYFFHVLQ--------AQ-
-----------SLGTKLRGFCSLA---AEGT-CQ-GK----TLFSPE-------------
--DFKKHGFYGA-NISTLLNM----GVLQEH---PTPQNYSFIHLCFQEFFAAMSYALG-
D------RVL--------KSGCF--NNI-TIIT-DLTDVYDRY--DLFGEPTICFL----
----FGLLSDQGMREMESIFKCS---------------L--SQE-THS-YLLQLAQEEVN
-----------------------------------YKHPNLEPYCWHLLHCFYEYQD-KR
FLTETMSN---------------------F-------------------YGMRIYVQTHM
EL---LVS--T----FCFK-FCHL-MDT-LQLN----------------DGGK-------
------K-K---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------P------------
------AQRP--------------------------------------------------
-------------------SGVVLYSWGPFT-----------------------------
----------------------------DSWWQMFFS-----------------------
--------------------------------IFKVPGSLRE---LN-LSGNS-LSC---
-------SAVQSLCDAL----ESPHCRLETL-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MAESFSAA

PF02758 // ENSGT00900000140813_0_Domain_0 (203, 325)

FD---LLWYLEKLS--D---EEFHSFKSHLEQ------
---------E--IQQFG--------L--PQI-PLTD-LEV-S-KEVLVNTLRSSYEEQHT
WNMTFSI----LQ-KLGHKDLCEKI---TIRQN---------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RNKEMHKCL-
--------MRTK----------------FLSQ--WETCRFSEIHYSFFSEVT--------
----------------------------------------------CDIFYILESSYDSS
T---SSKEN----LNVFLVGDRATGKSMITKMA-----VTKWT--V---------GEMWK
----------------------------------------------------------AP
IA

PF05729 // ENSGT00900000140813_0_Domain_2 (783, 930)

DILS-DP----RKVLFILEDLDN-MNVDLNVD------ES-A-----LCSDSRRK-VP
-VSVLLVSLLKRKMVPGCWVLVS-SRPSCEPSIKALM-N-----ERD--CYVTLQLSNEK
KQHYF----------------H--LF-FNN---------QERAVLTFKFVLM-SEILVDL
CEVPLLSWILCTVLNQQINQG-EDI-G--FS-CETPTDIYTHYLASVLASDPEVT-AR--
----------QHHLILLNRLCLLA---LEGL-SH-NT----LRFSRN-------------
--DLVSVGFTSD-DVSVLQAM----NILLRSSN-HQ-VRFEFIHLNIQEFCAALASLMVL
PRRWI-----------------P----SARR-R--K--KEKRE-LYDNFSPVVTSI----
----FGLLNEKRRKILETSLGCQ---------------LPMVES-LRQ-NLLMQMKYLGN
NP-------------------------------------NLMEHHMPLFYCFLENLE-EE
FVKEIMSF---------------------F-------------------SEATIFIQDNK
DL---MVS--L----YCLQ-HCQP-LQK-LKLS----------------VQQ-----VFR
--CETPIS-------------------------------------------MLTSSQIRG
LTFWMHIC-SLFYTKENFRELEICTSDFNRI---------SELLLC--KALRHP------
NC--Q-LQTLRLSY---------VSV-SSNFNDLFMSM----------------ACNQNL
TFLN-VNCI---------------------------------------------------
------------------------------------------------------------
--------------------------------------------PISP-KMFSLLCEA--
LSS-PTCNIQHL-S----------------------------------------------
------------------------LMRCDLQ-----------------------------
----------------------------ASACPEIAS-----------------------
--------------------------------ILISSKKLKK---LT-LSNNP-LKN---
-------DGVKILCDAL----FHPECVLESL-----------------------------
------------------------------------------------------------
------------------------------GLYFCCLTERCVAYIARV-LMFSTTLKHLD
L-SVNCLQNRAVL-ALTFPLSLP--ECH----L---------------------------
-----------------------QELEL--TGC-----FFNNEVCHYI------------
-------ASSLI-SNVHLRRLELGYNNLGDAGVES-LCNALQ-HQ-DC-KLETVG--LE-
--G-CMLTSACCT--------------------TLASVFSSSKTL-KKLNLIENNLGDEG
IMKLIQ--------GLGHPSCV--LE--L-------------------------------
---LGIGVS-DLSAETQSL------LM----------AVR-EKNTKLEFSSSFSTVKEGR
QFNDL-----LG------------------------------------------------
-----------------------------------------------------SGNPPEP
AST-----------------TPNYPWH---SI--FFKLPRKFSSMTEETTVSEQSL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MA---ASFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 322)

-LMWYLEELK--K---EEFRKFKEYLKQ------
---------M--TLHLE--------L--KQI-PWTE-VKKAS-REELANLLIKHYEEQQA
WNITLRI----FQ-KMDRKDLCMKVM-RER------------TG--------------YT
Q---------------------------------------------------TYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------AKRK----------------FSHL--WASKSVTEIHLY--------------
---------------------------------F-------QEEVKQEECEHLDHLFAPK
ET--GKQ-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RTVIIQGPQGIGKTTLLMKL-----LMAWS--D---------NRIFR
D--------RFLY-TFYFCCRELRELP-------ATSLAD-LISR-EW-----PDP-AAP
VTEIVS-QP----ERLLFVIDSFEE-LKDGLNEP------DS-A-----LCDDVTEK-RP
-VQVLLSSLLRKKVLPEASLLVA-VQPVCPKELRDRV-A-----ISE--IYEPRGFNESD
RLVYF----------------C--CF-FKD---------PKRAMEAFSVVRE-SEQLFSI
CQIPLLCWILCTSLKQEMQKGK-DL-T--LT-CQSTTSVYSCFIFNLFTPEG-AEGPTP-
-----------QSQRQLKALCSLA---AEGM-WT-DT----FEFRED-------------
--DLRRNGVVDT-DIPALLGT----KVLLKYGE-RE-SSYVFLHACIQEFCAALFYLLR-
SHLDH-----------------P--HPAVRSVQ-ELLVANFEKTRRARWIFLGCFL----
----TGLLNRQEQQKLDAFFGFQ---------------L--SQE-IKQ-QLHQCLKSLGE
H-G----------------------------------DPLGQVDSLAIFYCLFEMQD-PA
FVKQAVNL---------------------L-------------------QKADFHIIDNA
DL---VVS--A----YCLK-YCSS-LRK-LSFS----------------VQN-----VFK
-KED-EHS-----------S-----------------------------------TSDYS
LVCWHHIC-SVLTTSGHLTELQVQDSTLSES---------TFVTWC--NQLRHP------
SC--R-LQRLGINN---------VSF-SGPSGQLFEVL----------------FYQPDL
KYLS-FTLT-KLSRD-DVRSLCDALNYPAGN----VKEL--------AL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------VDCFLS-----------------------------
----------------------------PIDCEVLAC-----------------------
--------------------------------LLT

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2036)

NNKKLTY---LN-VSCND-LD----
-------AGLPLLCEAL----CNPDTVLVYL-----------------------------
------------------------------------------------------------
------------------------------MLAYCHLSEQCCEYISEM-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

HNKSVRYLD
L-GANVLKDEGLK-TLCEALKRP--DCR----L---------------------------
-----------------------DSLCL--VKC-----FITVAGCEDL------------
-------ASAL-I

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

SNQNLKILQIGCNEIGDVGVKL-LCGALT-HP-NC-RLEV-------
------------------------------------------------------------
------------------------------------------------------------
---LGLRKT-DFDEETQAL------LM----------AEE-ERNPNLTITDD-CDTVTRV
EI----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MEHSD----QLGFN---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LKDVLKKLD--K---TELNNFKSTLKS------
---------C--SLPQT--------M--KQI-SKLT-MDLAN-GAQLAEILTDYCPNDWV
KRVTFKI----LE-EINRADLAELVM-KQVEEAAS-KASE----EKVSSK----------
----------PSNL----------------------------------------------
----------------------------------------------NSF-----------
-------STW-------------------------------PPKLIDG---KEHKHKKE-
--------WRNM----------------YTEK--WKKNFWPKCNKEIYV-----------
---------------------------------------------DTESYRTLLTLCNPK
I---EMPFA----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 931)

TIVLHGPPGSGKTTMARRL-----MLEWS--E---------SKQAQ
---------SFSC-AFYISCRKLNNSK-------PCTFAH-LLSM-NN-----PS-WRYY
MIRRLV-LS----EQFLFVVDGFDE-LTFPAG------ALLR-D-----ICGDWNTV-KP
-VEVLLSSLLMRKMEPHSTLLVT-TQTQSLHQIYLMV-D-----QPV--LVETQGFLEPE
KQEYF----------------Q--QY-FEDEEGEEEGEGEGKALRALKEVKC-NEALFQM
ASLPAACGIFCLCLELGMKKGE-DL-A--LT-CQTYTSMFLNFLCRVFLQEACDGHLNKQ
------------LQILFKKICILA---ADSL-LE-QV----PILCEE-------------
--DFLKLKLNLN-KLHPVVYR----CIFLEDSS-CT-NCLSFICLSIQQLLAAIIFVQE-
LGQES-----------------K--DVSKYSIQ-KMLSREARL-KNPNLSGVLPFV----
----FSLLNKTHIQELETIFGCQ---------------I--SMG-VKR-KFLECE--LGE
NK-----------------------------------PFLLLMDLQEIFSCLYESQE-EE
FVKEAMAL---------------------F-------------------GEVSLHLKTNM
DL---VHA--S----FCLK-NSQN-LQT-MFLK----------------VEKA----VFP
-ENF-ATL----ES--------------------TAEDQR------------FQDK-KCM
LTLWTDFC-DTFHSNEKLAFLEIHESFLNSS---------SLEILC--EKLSS-A-----
PC--H-LQKVV--L-KNISPD--DA----YE-KLCLIF----------------CGYETI
SHLT-LQGG-KLDS--MLHSLCKVVKNPACN----LKFL--------SLG---------S
C------S----------------------------------------------------
---------TT---AQ-KWD---DFFPALKA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NQSLISLDLTDNNLLD-KGVRLLCNT--
WKQ-SKCILQRV-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EVCCKDLSS-----------------------
--------------------------------VLMV

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2054)

SQTLTH---LS-LAKNE-LGD---
-------NGVKKLCESL----SFPKC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LWSCNITSNGCHYLSKM-LGQA

PF13516 // ENSGT00900000140813_0_Domain_13 (2214, 2237)

PSLKHLD
L-GLNRIGTTGAK-FLCEALKSP--RSN----L---------------------------
-----------------------KSLWL--CGC-----SIIPTNCKDF------------
-------SEIL-RSNKSLNTLDLSQNVMGTDAVKI-FCESLK-LQ-IC-PLQTLR--LK-
--F-DEANPSIQK--------------------LIQEMKESHPQLSITSDQV----DPKK
---------------KSHSFPH--FI----------------------------------
----F-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LMWYLEELN--K---KEFVKFKEFLKQ------
---------E--VLQLG--------L--KQV-SWTE-VKKAS-RQDLASLLLKHYEEKPA
WDMTFRF----FQ-KINRKDLIERAK-REI------------DG--------------CP
K---------------------------------------------------LYRA----
------------------------------------------------------------
----------------------------------------------------------H-
--------MKTK----------------MTHD--SSRAFTISIQNF--------------
---------------------------------L-------KEKFTEDDYDCFENLFQSK
GT--ESK-P----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

VVFLSGGAGVGKTLMLKRL-----MLAWI--E---------SPVFL
H--------KFSY-IFYFCCREVKQLK-------TASLAE-LISR-EW-----PGP-SAP
IEEILS-KP----EKLLFIIDSLEG-MECDLFKW------ES-E-----LCDNCTEK-QP
-VNVLLSSLLRRKMLPESSLLIS-ATPESFEKMENRI-E-----YTH--VKIIKGLKERN
IKMSF----------------H--RL-FQD---------RNRAHEAFSLVRE-NEQLFTV
CQVPVLCWMVATCLKEEIEKGR-DP-V--SI-CRCTTSLYTTHIFNLFIPQN-AHSPSK-
-----------KSQDQLQGLCSLA---AEGM-WT-DT----FVFGEE-------------
--ALRRNGIMDS-DIPILLDI----GMLINIRE-SE-KSYIFLHPSVQEVCAAIFYLLK-
SHVDH-----------------P--SQEVKSIE-KLMFAFLKK-VKVQWIFFGSFI----
----FGLLHESEQKKLEAFFGHQ---------------L--SQE-IKR-QLYQCLETISG
NEE-----------------------------------LQEQIDGMKLFYCLFEMDD-DT
FLVEAMNC---------------------M-------------------EQINFVAKDYS
DV---IVA--A----HCLK-HCFT-LKK-LSFS----------------TQN-----VLS
-GAQ--EH-----------S-----------------------------------YMERL
LTAWNHIC-SVFIISKDIQELRMKDTNLSES---------AFSVLY--NNLKYH------
NYT---LNVLVANN---------VFF-VCEKYLFFEL-----------------IQNCNL
QHLN-LSLT-ILSHS-DVKLLCDVLSQAECN----IEEL--------VV-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------AACSIS-----------------------------
----------------------------SDDCKVFAS-----------------------
--------------------------------VLI

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2048)

SNKTLKH---LN-LASNT-LD----
-------KGIASLCKSL----CHPDCILEHL-----------------------------
------------------------------------------------------------
------------------------------VLANCSLNEKCWDYLSEV-LRR

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NKTLSHLD
I-SSNDLKDEGLK-VLCRALTLP--DSV----L---------------------------
-----------------------KSLSL--RHC-----LITISGCQDL------------
-------AEVL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

NNQNLVSLQVSNNKLEDTGVKL-LCDAIK-HP-NC-HLEDLG--LE-
--A-CELTGACCE--------------------DLASTFTQCKTL-WAMNLLKNALDYNG
LVVLCE--------ALKQQTCA--TY--V-------------------------------
---LGLQIT-DFDTETQAF------LV----------AEQ-EKNPCLRILSS-L------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MR

PF02758 // ENSGT00900000140813_0_Domain_0 (194, 332)

MA----SVRCK---LASYLEELE--D---IDLKKFKMHLED------
---------Y--PPQKG--------C--ISL-PRGQ-TTKAD-HLDLTTLMIDFNGEKRA
WSMAIWI----FA-AINRRDLYEKAK-MEEPKWDSDNAC--DS---------KPTVI---
--------CR-----------------------------------EESI-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LSYLSRISFCKKKKDYCRAYRKH-
--------VRSR----------------FQYI--EDRNARLGESV---------NLNKRY
T-LRLVKEHPSQKERVQELL------AIGQTAAKTRD------SA--MSSIKIEPLFD--
PDEENTEPV----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVVLQGAAGIGKTILARKI-----MLDWA--S---------GKLYK
D--------RFDY-LFYIYCREVSLMT-------KKSLGD-LIIS-CC-----PD-PKPP
LSKIVS-KP----SKILFLMDGFDE-LQGDFDEH------MG-D-----FCTDWQKA-ER
-GDILLSSLIRKRLLPEASLLIT-TRPVALEKLQHLL-D-----HSR--HVEILGFSEAR
RKEYF----------------F--KY-FSE---------EHQAKEAFRLIQE-NEILFTM
CFIPLVCWIVCTGLKQQMESGK-SL-AQ--T-SKTTTAVYVFFLSSLLQHRGGTQEHP--
------------LSANLRGLCSLA---ADGI-WN-QK----ILFDED-------------
--DLRLHGLQRV-DVSAFLRM----NLFQKEVD-CE-KLYSFIHMTFQEFFAAMYYLLE-
EEEE--------REMRNMSQ--H--TLPNRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTSYLEKKLSCK---------------I--SQQ-IRQ-ELLKWIEAKAK
AK-----------------------------------KLQIQPSQLELFYCLYEMQE-ED
FVQRAMNH---------------------F-------------------PKIEINLSTRM
---DHVVS--S----FCIG-NCQR-VES-LSLG----------------LFHN-----LT
KEEEE--------E------------------------------------E---------
---------------EEGQRHHVVSCVSPGS-----------------------------
------------------------------------------------------------
--------------------------HDACS----Y-----------HLV---------N
Y-----------------------------------------------------------
--------CLT---SS-FCR---GLFSALST-NQ

PF00560 // ENSGT00900000140813_0_Domain_8 (1775, 1801)

SLTELDLSDNTVGD-PGMRVLCET--
LQH-PGCNIQRL-W----------------------------------------------
------------------------LGRCGLS-----------------------------
----------------------------HHCCLGLSS-----------------------
--------------------------------VLSSNQ

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2064)

KLVE---LD-LSDNG-LGD---
-------SGVRLLCVGL----RHLFCNLQKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSDCCPDLALV-LSTNQSLTRLY
M-GENALGDSGVG-ILCEEIKHP--QCN----L---------------------------
-----------------------QKLGL--VNS-----GLTSACCPAL------------
-------SLAL-STNQ

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2385)

NLTHLYLRDNALGDKGVKV-LGEGLM-NA-NC-KLQMLE--LD-
--N-CNLTSHCCW--------------------DLSTVLTSNQ

PF00560 // ENSGT00900000140813_0_Domain_17 (2444, 2463)

SL-RKLSLGNNDLSDLG
IMLLCE--------VLKQ-NCL--LN--S-------------------------------
---LQLSKT-YFNNETKCA------LE----------TLQ-EEKPELSIVFEPSW-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MVDSPTFSSFTDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LLLYLEELN--N---EELNKFKLLLK-------
---------E--TIEPE--------H--CLM-PWTA-VKMAD-RQQLANLINKYYPEEQA
QKMTLEL----FA-KLNLREMCERAR-AKINWTPE-TMEQEM------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------AEEAELSAGTKYKIQ-
--------IKEK----------------FHIL---EKNSLLREASDFHHGLS--------
----------------------------------------------EEHQKLLVHLFDVE
IT--TGQQI----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RTVVLQGAAGVGKTALMRKA-----MLAWA--E---------GNLYR
H--------KFTY-VFYLNGKEISQVK-------EKSFAQ-LISK-DW-----PS-TEIP
IEKILS-QP----SNLLFIIDSFDE-LNFAFEEP------EF-A-----LCGDWTQV-HP
-VSFLISSLLRKVMLPESSLLVT-VRRTASNRLKRLL-TQRLLRSRL--YVDLQGMSTDA
RKEYI----------------Y--QF-FED---------RTWAMNAFNSIRS-NEMLFNM
CRVPLVCRFICACLKQQMEKND-DV-T--KT-CQTATAVFTCYISSLFAPV-GEHFPNLP
------------NEAQLRNLCYLA---AKGV-WT-MT----HVLYRN-------------
--DLRKHGFTTC-DTSTFLDI----NILQKDTE-YE-NCYVFTHLHIQEFLGAMFYLLK-
RDLKH--------------KEHS--SQSLEDLK-LLLESRSDQ--DPHLTQLKYFL----
----FGLLNADIVKQLEETFKCR---------------L--SLK-IKW-EVLQWVKVLGN
RD-----------------------------------TFPPWLVFMDLFHYLYETQD-EA
FVAQAMGK---------------------F-------------------SKVVINMSKEI
DL---PVS--S----FCLK-HCRC-LQT-LKLA----------------IN---------
------MV----NSSA-----AA--E------------------------NGQI-DGNHI
TQCWQNLF-SVLHTNEHLTQLDLSHSNLDEL---------IMKIFC--QELRHP------
NC--K-LQKFLLRC---------VSF-PHGYQDIFSFL----------------TCQ

PF13516 // ENSGT00900000140813_0_Domain_6 (1618, 1642)

QNL
MYLD-LKGN-KIEDN-GIKSLCEALQYPECK----LQNL--------RLE---------S
CN----------------------------------------------------------
---------LT---PI-CCA---DISKALIK-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SQNLVFLSLSTNNLLD-EGVKLLCEA--
LGH-PECYLERL-S----------------------------------------------
------------------------LESCGLT-----------------------------
----------------------------EASCEALSL-----------------------
--------------------------------ALI

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNKRLTH---LC-LSNNK-VGD---
-------HGIKLLSAAL----KHPEC----------------------------------
--------------------------TLQ-SLV---------------------------
-------------------------------LRCCHFTPISSEYLSTS-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

HNKSLIHLD
L-GSNCLQDDGAN-LLCNVFRKP--SCN----L---------------------------
-----------------------QDLEL--IGS-----VLTTACCPDL------------
-------ASAI-L

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2374)

NSPNLLSLDLGYNDLRDEGVKI-LCEALR-NP-KC-NIQRLG--LE-
--H-CGLTSLCCQ--------------------DLSSALLSNKRL-VKMNLTQNTLGREG
IRTLCE--------VLRCTECK--LQ--V-------------------------------
---LGLWKD-TFDKEAQRL------LE----------AVR-VSNPNLAIDDSYNN-----
--K---------------------------------------------------------
--------------------------------------------------EWWSWWWYL-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MA---ASFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 322)

-LMWYLEELK--K---EEFRKFKEHLKQ------
---------M--TLHLE--------L--KRI-PWTE-VKKAS-REELANLLIKHYEEQQA
WNITLRI----FQ-KMDRKDLCMKVM-RER------------TG--------------YT
Q---------------------------------------------------TYQA----
------------------------------------------------------------
----------------------------------------------------------H-
--------AKQK----------------FSRL--WSSKSVTEIHLY--------------
---------------------------------F-------QAEVRQEECEHLDHLFAPT
ET--GKQ-P----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

RTVVIQGPQGIGKTTLLIKL-----LMAWS--D---------NKIFR
D--------RFLY-TFYFCCRELRELP-------ATSLAD-LISR-EW-----PDP-AAP
ITEIVS-QP----ERLLFVIDSFEE-LQGGLNEP------DS-A-----LCHDVMEK-RP
-VQVLLSSLLRRKMLPEASLLVA-VQPVCPKELRDRV-A-----ISE--IYEPRGFNESD
RLVYF----------------C--CF-FKD---------PKRALEAFNLVRE-SEQLFSI
CQIPLLCWILCTSLKQEMQKGK-DL-T--VT-CQSTTSVYSSFIFNLFTPEG-AEGPTP-
-----------QSQCQLKALCSLA---AEGM-WT-DT----FEFRED-------------
--DLRRNGVVDA-DIPALLGT----KVLLKYGE-RE-SSYVFLHACVQEFCAALFYLLN-
SHLDH-----------------P--HPAVRCVQ-ELLIAHFEKRRRAHWIFLGCFL----
----TGLLNKQEQQKLDAFFGFQ---------------L--SQE-IKQ-QLHQCLKSLGE
H-G----------------------------------DPQGQVDSLAIFYCLFEMQD-PA
FVKQAVNL---------------------L-------------------HKADFHIIDNA
DL---VVS--A----YCLK-YCSS-LRK-LSFS----------------VQN-----VFK
-KED-EHS-----------S-----------------------------------TSDYS
LVCWHHIC-SVLTTSGHLTELQVQDSTLSES---------TFVTWC--NQLRHP------
SC--R-LQRLGINN---------VSF-SGPSGQLFEVL----------------FYQPDL
KYLS-FTLT-KLSRD-DVRSLCDALNYPAGN----VKEL--------AL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------VNCFLS-----------------------------
----------------------------PIDCEVLAF-----------------------
--------------------------------LLT

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2036)

NNKKLTY---LN-VSCNH-LD----
-------TGLPLLCEAL----CNPDTVLVYL-----------------------------
------------------------------------------------------------
------------------------------MLAYCHLSEQCCEYISEM-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

HNKSVRYLD
L-GANVLKDEGLK-TLCEALKRP--DCR----L---------------------------
-----------------------DSLCL--VKC-----FITAAGCEDL------------
-------ASAL-I

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

SNQNLKILQIGCNEIGDVGVKL-LCGALM-RP-DC-HLEILG--LE-
--E-CGLTSTCCK--------------------DLASVLTS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SKTL-QQLNLTLNALDYAG
VVVLCE--------ALRHPECA--LQ--V-------------------------------
---LGLRKT-DFDEETQAL------LM----------AEE-ERNPNLTITDD-CDTITRV
I-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MVSSA----QMGFN--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LQALLEQLS--Q---DELSKFKYLITT------
---------F--SLAHE--------L--QKI-PHKE-VDKAD-GKQLVEILTSHCDSYWV
EMASLQV----FE-KMHRMDLSERAK-DEVREAAL-KSFN----KRK------PLSLG--
------ITRKERPP---------------------------------LDVDEMLERLK-T
EALAFP---------------------------------ET---KGNVI-----------
-------CLG-------------------------------KDVFKGKKPDKDNRCRYI-
--------LKTK----------------FREM--WK--SWPGDSKEVQV-----------
---------------------------------------------MAERYKMLIPFSNPR
VL--PGPFS----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLYGPAGLGKTTLAQKL-----MLDWA--E---------DNLIH
---------KFKY-AFYLSCRELSRLG-------PCSFAE-LVFR-DW-----PE-LQDD
IPHILA-QA----RKILFVIDGFDE-LGAAPG------ALIE-D-----ICGDWEKK-KP
-VPVLLGSLLNRVMLPKAALLVT-TRPRALRDLRILA-E-----EPI--YVRVEGFLEED
RRAYF----------------L--RH-FGD---------EDRAMRAFELMRS-NADLFQR
GSAPAVCWIVCTTLKLQMEKGE-DP-V--PT-CLTRTGLFLRFLCSRFPQ-------GAQ
------------LRGALRTLSLLA---AQGL-WA-QT----SVLHRE-------------
--DLERLGVQES-DLRLFLDG----DILRQDRV-SK-GCYSFIHLSFQQFLTALFYALE-
KEEEE-------------DRDGH--TSDIGDVQ-KLLSGVERL-RNPDLIQAGYYY----
----FGLANEKRAKELEATFGCR---------------M--SPD-IKQ-ELLRCDISCKG
G------------------------------------H-STVTDLQELLGCLYESQE-EE
LVKEVMAQ---------------------F-------------------KEISLHLN-AV
DV---VPS--S----FCVK-HCRN-LQK-MSLQ----------------VIK-----ENL
-PENVTAS----ES--------------------DAEVER------------SQDD-QHM
LPFWTDLC-SIFGSNKDLMGLAINDSFLSAS---------LVRILC--EQIAS-D-----
TC--H-LQRVV--F-KNISPA--DA----HR-NLCLAL----------------RGHKTV
TYLT-LQGN-DQDD--MFPALCEVLRHPECN----LRYL--------GLV---------S
C------S----------------------------------------------------
---------AT---TQ-QWA---DLSLALEV-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1795)

NQSLTCVNLSDNELLD-EGAKLLYTT--
LRH-PKCFLQRL-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EANCKDLAA-----------------------
--------------------------------VLVVSRE

PF13516 // ENSGT00900000140813_0_Domain_11 (2020, 2054)

LTH---LC-LAKNP-IGN---
-------TGVKFLCEGL----RYPEC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LWNCDITSDGCCDLAKL-LQEK

PF13516 // ENSGT00900000140813_0_Domain_13 (2214, 2237)

SSLSCLD
L-GLNHIGVKGMK-FLCEALRKP--LCN----L---------------------------
-----------------------RCLWL--WGC-----SIPPFSCEDL------------
-------CSAL-SC

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2377)

NQSLVTLDLGQNPLGSSGVKM-LFETLT-CS-SG-TLRTLR--LK-
--I-DDFNDELNK--------------------LLEEIEEKNPQLIIDTEKH----HPWE
---------------ERPSSHD--FM----------------------------------
----I-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------M-SDVNPPSD------------T-PVPFSSS-------------S-T
H---SSCNPPWTFSCYPGSPCENG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

VMLYMRYVS--N---EELQWFKQFLLN------
---------E--L-RAG--------T--TPI-TWDQ-VKRAS-WAEVVHLLIERFPGRRA
WDVTSNI----FA-AMKRDKMCALVH-REINAILP-TLEPEDLNVG------E-------
------------------------------------------------------------
------------------------------------------------------------
-------TQV-------------------------------NLEEGES--GKIRQYKLN-
--------VTVK----------------CFPT--WDFMTWPGNQSDFFYQDV--------
----------------------------------------------HRHREYLPCLLLPK
RP--QGRQP----K

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 929)

TVVIQGAPGIGKTALAKTV-----MLEWA--S---------NRFYA
H--------KPWC-AFYFHCQEMNQTT-------EHSFSE-LIEH-KW-----PG-SQDL
VAKIMS-KP----DQLLLLLDGFEE-LTSTLI------NRPQ-D-----LSEDWRQK-LP
-GSVLLSSLLSKRMLPEATLLIM-IRCTSWPTCKPLL-K-----CPS--LVTLPGFNTME
KIKYF----------------Q--MY-FGH---------TE-TDRVLSFAME-NTILFSM
CQVPVVCWMVCSGLKQQMERGN-NL-T--QA-CPNATSVFVRYISSLFPTRA-ENFSRKI
------------HQAQLEGLCRLA---ADGM-WH-RQ----WVFGKE-------------
--DLEEARLDQT-GVAAFLGM----SVLRRIAG-EE-DRYTFTLLIFQEFFAALFYVLC-
FPQRL--------------QNFH--VLSHVNIQ-RLIASPR-G-SKSYLSHMGLFL----
----FGFLNVTCASAVEQSFRCK---------------V--SFN-NKR-KLLKVIPLLQK
CE-----------------------------------PPSPCSGVPQLFYCLREIRE-EA
FVSQALNG---------------------Y-------------------RKAVLKIGNSK
DV---QVS--A----FCLK-RCEH-LQE-VELA----------------VTL-----NLR
-NVWKLSS----G-------------------------------SCPGS--EAPES-KEL
HCWWQDLC-SVFATNDKLEVLTLTNSALGPP---------FLKALA--AALKH-P-----
QC--K-LQKLL--L-RRVNST--ML---N-Q-DLIGVL----------------MGNKHL
RYLE-IQHV-EVESN-VVKLLCKALRSPRCR----LQCL--------RLE---------D
C------L----------------------------------------------------
---------AT---PR-IWT---DLGSNLRV-NRHLKTLILTKNSLEN-CGACY------
--L-SVAQLERL-S----------------------------------------------
------------------------IENCNLT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QLSCESLASC-LRK

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2236)

SKMLTHLS
L-AENALKDEGVK-HIWNALSHL--RCP----L---------------------------
-----------------------QRLVL--RKC-----DLTFDCCQDM------------
-------ISAL-C

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNKTLKSLDLSFNSLKDDGVIL-LCEALK-NP-DC-TLQILE--LE-
--N-CLFTSICCQ--------------------AMASMLC

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2465)

KNQHL-RHLDLSKNVIEVDG
ILTLCE--------AFSSQKKR--EE--V-------------------------------
---I------LET-LSPKN------NN----------NNG-DIAIGTRS-----LIE---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MAGSSGYG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLKPLQKLS--D---EEFQRFKELLRK------
---------E--PEKFK--------L--KPI-SWTK-IENSS-KEDLVTLLNTHYPGQ-A
WDMVLSL----FL-QVNREDLSIMAQ-KKKRH----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------KQTKYKKF-
--------MKTT----------------FQRI--WTMETNTHIPDR--------------
---------------------------------N-------YHLIVETQYKALQEIFDSE
-----SE-P----V

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TAIVTGATGEGKTTFLRKA-----MLDWA--S---------GVLLQ
N--------RFQY-VFFFSVFLLNKTT-------ELSLAE-LISS-TL-----PES-SET
VDDILS-DP----KRILFILDGFDY-LKFDLE-L------RT-N-----LCNDWRKR-LP
-TQIVLSSLLQKIMLPGCSLLLE-LGQISVPKIRHLL-K-----YPR--VITMQGFSERS
VEFYC----------------M--SF--FD---------NQRGIEVAENLRN-NE-VLHL
CSNPYLCWMFCSCLKWQFDREE-EG-Y--FK-AKTDAAFFTNFMVSAFKSTY-AHSPSK-
-----------QNRAQLKTLCTLA---VEGM-WK-EL----FVFDSE-------------
--DLRRNGISES-DKAVWLRM----QFLQNHG-----NHTVFYHPTLQSYFAAMFYFLK-
QDKDI-----------------C--VPVIGSIP-QLLGNMYAR-GQTQWLQLGTFL----
----FGLINEQVIALLQPCFGFI---------------Q--PIY-VRQ-EIISYFKCLGQ
QEC----------------------------------NEKL-ERAQNLFSCLRDSQE-ER
FVRQVVDL---------------------F-------------------EEITVDISSSD
VL---SVT--A----YALQ-KSSK-LKK-LHLH----------------IQKR----VFS
-EIYCPDH-----------C-------------------K-T-------RTSI-GKRRNT
AEYWKTLC-GIFC---NLHVLDLDSCQFNEK---------AIQDLC--HSMSPSPTVPLT
AF--K-LQSLLCSF---------MTD-FGD-GSLFHTL----------------LYLPHL
KYLN-LYGT-YLSSD-VIEKLCSALRCSACR----VEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GKCGIS-----------------------------
----------------------------SKACGIIAT-----------------------
--------------------------------SLINS-KVKH---LS-LVENP-LKN---
-------KGVMSLCEML----KDPSCVLQSL-----------------------------
------------------------------------------------------------
------------------------------MLSYCCLTFIACGHLYEA-LLSNKHLSLLD
L-GSNFLEDTGVN-LLCEALKDP--NCT----L---------------------------
-----------------------KELWL--PGC-----FLTSECCEEI------------
-------SAVL-TCNRNLKTLKLGNNNIQDTGVRQ-LCEALS-HP-NC-NLECLG--LD-
--L-CEFTSDCCK--------------------DLALALTTCKTL-NSLNLDWKTLDHSG
LVVLCE--------ALNHKRCN--LK--M-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------R------------LEARP----DLREF------FSL-N
L---RSHTWSTMTSP----QL

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 326)

EWT---LQTLLEQLN--E---DELKSFKSLLWA------
---------L--PLEDV--------L--QKT-PWSE-VEEAD-GKKLAEILVNTSSENWI
RNATVNI----LE-EMNLMELCKMAK--AEM-----------------------------
------------------------------------------------------------
--MEYG---------------------------------QVQETDNPEL-----------
-------EDA-------------------------------EEDSELAKPGVKEGRRNS-
---------MEK----------------QSLV--WKNTFWQGDIDSFHDDVT--------
-----------------------------------------------LRNLRFIPFLNPI
TP--RKLTP----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLHGPAGVGKTTLAKKC-----MLDWT--D---------CNLSP
---------TVRY-AFYLSCKELSHMG-------PCSFAE-LISK-DW-----PE-LQDD
IPSILA-QA----QRILFVVDGLEE-LKVPPG------ALIQ-D-----ICGDWEKK-KP
-VPVLLGSLLNRYMLPKAALLVT-TRPRALRDLQLLA-Q-----QPI--YIRVEGFLEED
RRAYF----------------L--RH-FGD---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DP-V--PT-CLTRTGLFLRFLCSRFPQG-------AQ
------------LQGALRTLSFLA---AQGL-WA-QM----SVFHQE-------------
--DLERLGVQES-DLRLFLDG----DILRQDRV-SK-GCYSFIHLSVQQFFAGLFYALE-
KE------EE--------DRDGH--AWDIGDIQ-KLLSGEERV-RNPDLIQVGHFL----
----FGLANEKRANELEAAFGCR---------------I--SPD-IKQ-ELLRCKAHLHA
NK-----------------------------------P-LSMTDLKEVLVCLYESQE-EE
LAKVVVAP---------------------F-------------------KEISIHLTNTS
EV---MHC--S----FSLK-HCQD-LQK-LSLQ----------------VAKG----VFL
-ENY-MDS----EL--------------------DIEFERC-TYL--TIPNWARQD-LRS
LCLWTDFC-SLFSSNSNLKFLEVKQSFLSDS---------SVRILC--DHITR-S-----
TC--H-LQKVV--I-KNVTPD--TA----YR-DFCLAF----------------IGKKTL
THLT-LEGH-IEWERTMMLMLCDLLRNHKCN----LQYL--------RLG---------G
H------C----------------------------------------------------
---------AT---PE-QWA---EFFYVLKA-NQSLKHLHISANVLLD-EGAKLLYKT--
MTH-PEHFLQML-S----------------------------------------------
------------------------LENCRLT-----------------------------
----------------------------EASCKDLAA-----------------------
--------------------------------VLVVSKKLTH---LC-LAKNL-IGD---
-------TGVKFLCEGL----SYPEC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LQQCSITKLGCRYISEA-LQEACSLTNLD
L-SLNQIA-RGLW-ILCQALENP--NCN----L---------------------------
-----------------------KHLR---------------------------------
---------------------------------------------------------LK-
--S-YGTSLEIKK--------------------LLEEVKEKNPKLTIDCNAS------GA
---------------MAPRCCD--FF----------------------------------
----C-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MLHL----AGRDGLCR

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LSTYLEELE--A---VELKKFKFYLGT------
---------V--TELGE--------G--GRI-PWGR-METAG-PLEMAQLLITHFGTAEA
WRLALSI----FE-WMNRKDLWERGQ-REDLVKDT----P--PG--------GPSSL---
------------------------------------------------------GN----
------------------------------------------------------------
---QS-TCLL-------------------------------EVSVATPKKDPQEAYRDY-
--------VRRK----------------FRLM--EDRNARLGECV---------NLSHRY
TRLLLVKEHSNPMRAQQQLL------DTGREHARTVG--------HQTSPIKIETLFEPD
EE--RPEPP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RTVVMQGAAGIGKSMLAHKV-----MLDWA--D---------GKLFQ
G--------RFDY-LFYINCRELNQSAA------ERSMQD-LISS-CW-----PE-PGEP
LRELVH-VP----KRLLFIIDGFDE-LKPSFHDP------QG-P-----WCLCWEEK-RP
-TELLLSSLIRKKLLPELSLLIT-TRPTALEKLHRLL-E-----HPR--HVEILGFSEAE
REEYF----------------Y--KY-FHD---------AEQAGHVFNYVRD-NEPLFTM
CFVPLVCWVVCTCLQQQLEGGG-LL-R--QT-SRTTTAVYMLYLLSLMQPKPGT-PRL--
-----------QPPPNQRGLCSLA---ADGL-WN-QK----ILFEEQ-------------
--DLRRHGLDGA-DVSAFLNM----NIFQKDIN-CE-RYYSFIHLSFQEFFAAMYYLLD-
Q--GE--------------R--G--AGPEQDVN-RLLAEYAFS-ERSFLALTTRFL----
----FGLLNEETRSHLEKSLCWK---------------V--SPC-IKT-QLLQWIQSKAQ
SA-----------------------------------GSTLQQGSLELFSCLYEIQE-EE
FIQQALSH---------------------F-------------------QVIVVSNIA-S
QM-EHVVS--S----FCLK-NCRS-AQV-LHLY----------------GA------RYS
-ADREDRA--R-CS---------------------------------------AGT---H
TL------------------------L-------------------------V-------
QL--R--------PERTVLLD-------AYSEHLAVAL----------------CTNPNL
IELA-LYRN-ALGSR-GVKLLCQGLRHPNCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------GIS---SS-ACE---DLATALIA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NRNLTRLDLSSNGIGL-PGMTLLCEG--
LRH-PRCRLQMLQ-----------------------------------------------
------------------------LRKCQLE-----------------------------
----------------------------SGACQEMAS-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

TNPHLVE---LD-LTGNA-LED---
-------LGLRFLCQGL----RHPVC----------------------------------
--------------------------RLQ-TLW---------------------------
-------------------------------LKICHLTAPACEGLAST-LSV

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NQSLTELD
L-SLNDLGDPGAL-LLCEGLRHA--TCK----L---------------------------
-----------------------QTLRL--GIC-----RLGAGACEGL------------
-------SAVL-QA

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2373)

NPHLRELDLSFNDLGDWGLWL-LAEGLQ-HP-TC-RLRKLW--LD-
--S-CGLTAKACK--------------------SLYFTLGV

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NQTL-TELYLTHNALGDTG
VQLLCK--------RLSHPGCK--LR--V-------------------------------
---LWLFGM-DLSKMTHGR------LA----------ALR-VTKPYLDIGC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
------------SPSENDS-----------------R----A------------------
--ILKDN-----GS-EEVEQT----SGFQAGSE-QE------------------------
---------------------Q---TLDNGGYL----QDYKTH-MIAKFDTSVDLY----
----YDSPEVKLLSDAFKPYQKTFQP

PF05729 // ENSGT00900000140813_0_Domain_3 (1227, 1408)

HTIILHGRPGVGK--SVL-ARS-IVLDWAQDKLF
------------------------------------------------------------
-------------------------------------------------QKMSY------
---VFSLD--L----FSVD-NTHE-LCP-VVAL----------------Q----------
------------------------------------------------------------
-------------------------ETQCKP---------LL------------------
----------------MEWWG--N----FCS-VLGSHWN---------LKELDLGLRQSE
LYLN-LGNT-PMKDD-DMKLACEALKHPKCS----LETL--------RLD---------S
CELTLIGY----------------------------------------------------
---------EM-------------ISTLLIS-SSSLKCLSLAKNTVGV-KSMISLGNA--
LSS-STCPLQKL-I----------------------------------------------
------------------------LDSYGLT-----------------------------
----------------------------HASCHLLVS-----------------------
--------------------------------SLF

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNQNLTH---LC-LSNNS-LGT---
-------EGVQLLCQFL----RNPEC----------------------------------
--------------------------ALQ-RL----------------------------
------------------------------ILNHCNIVDDAYSFLALR-LA

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

NNTKLTHLS
L-TMNPVGDDAMK-LLCEALKEP--TCY----L---------------------------
-----------------------XELEL--VDC-----QLTQNCCEDL------------
-------ACMI-TTT

PF13516 // ENSGT00900000140813_0_Domain_15 (2356, 2378)

KHLKSLDLGNNTLGDKGVIT-LCEGLK-QS-IS-SLRRLG--LG-
--A-CRLTSKCCE--------------------ALSLALSC

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NPHL-NSLNLVKNDFSTSG
KLKLCS--------AFQSPVSN--L-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MA---ESFFSDFG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 322)

-LLWYLKELR--K---EEFWKFKELLKQ------
---------E--PLKFE--------L--KPI-PWTE-LKKAS-KEDVAKLLDTHYPGKRA
WELTLNL----FL-QISRKDLWTKAQ-EEM-S----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------NLNPYRKQ-
--------IKEK----------------FQLI--WEKETCLHVPER--------------
---------------------------------F-------YKESMRHECTVLNKAYTVA
------AAP----V

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVVEGPDGIGKTTLLRKV-----MLDWA--E---------GNLWK
D--------RFTF-VFFLTVYEMNSIT-------ETSLPE-ILSR-DW-----PES-SEK
IEDIFS-QP----ERILLIMDGFEQ-LKLDLD-H------QA-D-----VCDDWRQR-QP
-LPIILSSLLQKKMLPECSLLLA-LGQMGMRKNYFVL-E-----HPK--LIKLSGFTEPE
RKMYF----------------S--CF-FGE---------KNKALKVFNFVRE-IGPLFIL
CHNPFICWLVCTCMKYRLERGE-DL-E--IN-SQNTTSLHASFITNVFQAGS-QSSPPK-
-----------LNRARLRNLSALA---AEGL-WT-HT----FVFGRE-------------
--DLRRNGLSES-EGLMWVSM----KLLQRSG-----DCFTFIHVCIQEFCAAMFYLLR-
GPKDS-----------------P--NPAIGSIT-QLVRASVAQ-PQNFLTQMGVFV----
----FGISTEEIASMLEMSFGFP---------------L--SKD-LQR-EIAQCLKSFSQ
CE-----------------------------------ADREAIGFQELFSCLFETQE-KE
FVTQVMNF---------------------F-------------------EEVYIYIANIE
HL---VIA--S----FCVK-HCRN-LTT-LRLC----------------MEN-----IFP
-DDSGCVS-----------E-------------------R-N-------EK---------
LMYWRELC-SMFSNNKNFQTLDMENTSFDDA---------SLAILC--KALAQP------
VC--K-LQKLMLTF---------MSD-FGHDTELFRAV----------------LHNPHL
KILS-LYGT-SLCHT-KVKHLCETLRHPMCR----IEEL--------ML-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MYCCLT-----------------------------
----------------------------CVSCEAISE-----------------------
--------------------------------G---------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------LARSKSLSLLD
L-GSNHLEDSAVA-LLCEALKHP--DCS----I---------------------------
-----------------------RELWL--MAC-----FLTSDSCKDI------------
-------ADVL-ICNEKLKILKLGHNEIGDAGVRQ-LCEALK-HP-NC-KLECLG--LQ-
--T-CRITHACCE--------------------DLAAALVASKTL-RSLNLDWITLDPEG
VVLLCA--------ALSHPDCA--LQ--M-------------------------------
---LGLQKS-AFDEESQKM------LM----------ALE-EKCPHLSISHEPWIEE---
--EYR-----IR------------------------------------------------
--------------------------------------------------GVIP------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
--------------------------------------------MKVAEGLEL-GAVDLL
QDPLLNLVTLSTGPTCSMLPKNP------------L-------------------FPQ-N
L---SSQPCLKMEGDKSLTFSSYG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LQWCLHELD--K---EEFQTFKELLKK------
---------K--SSEST--------T--CSI-PQFE-IENAN-VECLALLLHEYYGASLA
WATSISI----FE-SMNLPTLSEKAR-DDMKRHS-----PEDLEPTTT--GQGPSKEEVP
GI-----SQAVQQESA--TAAE-------------------------TKEQEISQAME--
QE-GATAA---------ETEAQEISQAMEQEGA---------------------------
-----T---A-------------------------------AETEEQECGGDKWDYKSH-
--------VVTK----------------FAVK--EDVH-RGFEKT---------------
------------------------------------A-------DWPEM-QMLAGAFNSD
Q---WGFRP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 925)

HTVVLHGKSGIGKSALARRI-----VLCWA--Q---------GGLYQ
G--------MFSY-VFFLPVREIQQKK-------ETSVAE-FISR-EW-----PD-PQAP
VTEIMS-RP----ERLLFIIDGFDD-LG-SVLNS------DT-K-----LCKDWAEK-QP
-PFILIQSLLRKVLLPESFLMVT-VRDVGIEKLKSEV-V-----SPR--YLFVRGITAEQ
RIHLL----------------L--ER-GIG---------EHQKTQGLCAIMN-NRKLFDQ
CQVPAVGSLICVALQLQDVVGE-SI-A--PF-GQTLTGLYAAFVFHQLTPRG-VARRCLN
----------LEERVVLKRFCRMA---VEGV-WN-MK----SVFDGD-------------
--DLMVHGLGES-ELRTLFHM----NILLRDSH-CE-EFYTFFHLSLQDFCAALYYVLE-
GLEIE--------------PALC--PLFVEKTK-RSMELQQAG-FHIHLLGMKRFL----
----FGLVSEDVRKPLEVLLGCP---------------V--PL-GVKQ-KLLHWVSLLGQ
QPN----------------------------------AA-APGDTLDAFRCLFETQD-KE
FVRSALNG---------------------F-------------------QEVWLPINQNL
DL---IAS--S----FCLQ-HGPY-LRK-IRVD----------------VKG-----IFP
-RDELAEA----WP--------------------VV-----------PR--WMRGK-TLM
EDQWEDFC-SVLSTHPHLRQLDLGSSILTER---------AMKTLC--AKLRH-P-----
TY--C-LWSA----------------------APLENL----------------IANREP
KILN-LGGT-HLKEE-DVRMACESLRYVS-------------------------------
------------------------------------------------------------
-----------------GRA---FISQILTT-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SPSLKSLSLAGNEVTD-QGVTPLSDA--
LRV-SQCALQKL-T----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------LPHC----------------------------------
--------------------------SLR-RLM---------------------------
-------------------------------LNRCNLDTAGCGFLALA-LMG

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NAWLTHLS
L-SVNPVEDNGMK-LLCEVMREP--SCH----L---------------------------
-----------------------QDLEL--VKC-----HLTAACCESL------------
-------SCVI-SR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

SRHLQSLDLTDNALGDGGVAV-LCEGLK-QK-KS-VLTRLG--LK-
--A-CGLTSDCCE--------------------ALSLALSC

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NQH-LTSLNLVQNNFSPEG
MMKLCS--------AFACPTSN--LQ--I-------------------------------
---IGLWKW-QYPVQIKKL------LE----------EVQ-LLKPQIVIDGSWHSFD---
--E---------------------------------------------------------
--------------------------------------------------DDRYWWKN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MKME----STRCK---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LARYLEDLE--D---VDLKKFKMHLED------
---------Y--PPQKG--------C--ISL-PRGQ-TEKAD-HVDLATLMIDFNGEEKA
WAMAVWI----FA-AINRRDLYEKAK-RDEPKWGSDNAR--VS---------NSTVI---
--------CQ-----------------------------------EDSI-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LEYLSRISICKKKKDYCKKYRKY-
--------MRSR----------------FQCI--EDRNARLGESV---------SLNKRY
TPLRLIKEHRSQQEREHELL------AIGKT--KTWE------SP--VSPIKMELLFD--
PDDEHSEPV----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVVFQGAAGIGKTILARKI-----MLDWA--S---------GTLYQ
D--------RFDY-LFYIHCREVSLVT-------QRSLGD-LIMS-CC-----PD-PNPP
IRKIVS-KP----SRILFLMDGFDE-LQGAFDEH------IG-P-----LCTDWQKA-ER
-GDILLSSLIRKKLLPEASLLIT-TRPVALEKLQHLL-D-----HPR--HVEILGFSEAK
RKEYF----------------F--KY-FSD---------EAQARAAFSLIQE-NEVLFTM
CFIPLVCWIVCTGLKQQMESGK-SL-AQ--T-SKTTTAVYTFFLSSLLQPRGGSQEHR--
------------LCSHLWGLCSLA---ADGI-WN-QK----ILFEES-------------
--DLRNHGLQKA-DVSAFLRM----NLFQKEVD-CE-KFYSFIHMTFQEFFAAMYYLLE-
EEKE--------GR-TNVPGSRL--KLPSRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTCYLEKKLSCK---------------I--SQQ-IRL-ELLKWIEVKAK
AK-----------------------------------KLQIQPSQLELFYCLYEMQE-ED
FVQRAMDY---------------------F-------------------PKIEINLSTRM
---DHVVS--S----FCIE-NCHR-VES-LSLG----------------FLHN-----MP
KEEEE--------E------------------------------------E---------
---------------KEGRHLDMVQCVLPGS-----------------------------
------------------------------------------------------------
--------------------------HAACS----H-----------RLV---------N
S-----------------------------------------------------------
--------HLT---SS-FCR---GLFSVLST-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SQSLTELDLSDNSLGD-PGMRVLCET--
LQH-PDCNIRRL-W----------------------------------------------
------------------------LGRCGLS-----------------------------
----------------------------HECCFDISL-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNQKLVE---LD-LSDNT-LGD---
-------FGIRLLCVGL----KHLLCNLKKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSACCQDLASV-LS

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2232)

TNCSLTRLY
V-GENALGDTGVA-ILCEKAKNP--QCN----L---------------------------
-----------------------QKLGL--VNS-----GLTSVCCSAL------------
-------SSVL-S

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

TNQNLTHLYLRGNTLGDKGIKL-LCEGLL-HP-DC-KLQVLE--LD-
--N-CSLTSHCCW--------------------DLSTLLTS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SQSL-RKLSLGNNDLGDLG
VMMFCE--------VLKQQSCL--LQ--N-------------------------------
---LGLSEM-YFNYETKRA------LE----------TLQ-EEKPELTIIFEPSW-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MDQPEAPCSSTGPR--LAVAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLAALEELS--Q---EQLKRFRHKLRD------
------------VGPDG-----------RSI-PWGR-LERAD-AVDLAEQLAQFYGPEPA
LEVARKT----LK-RADARDVAAQLQ-EQRLQR---------L---------GLG-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SG-TLLSVSEYKKKYREH-
--------VLQL----------------HARV--KERNARS------------VKITKRF
TKLLIAPESAAPEEE--ALGPAE-------EPEP--------GRARRSDTHTFNRLFRRD
E---EGRRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYQ
G--------QVDF-AFFLPCGELLERPG------TRSLAD-LILD-QC-----PD-RGAP
VPQMLA-QP----QRLLFILDGADE-LPALGGP--------EAA-----PCTDPFEA-AS
-GARVLGGLLSKALLPTALLLVT-TRAAAPGRLQGRL-C-----SPQ--CAEVRGFSDKD
KKKYF----------------Y--KF-FRD---------ERRAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLRQQLELGR-DL-S--RT-SKTTTSVYLLFITSVLSSAPVADGP---
-----------RLQGDLRNLCRLA---REGVLGR--R----AQFAEK-------------
--ELEQLELRGSKVQTLFLSKKELPGVLET-----E-VTYQFIDQSFQEFLAALSYLLE-
DGGVP-------------------R-TAAGGVG-TLLRGDTQP--HSHLVLTTRFL----
----FGLLSAERMRDIQRHFGC-----------------MVSER-VKQ-EALRWVQGQGQ
GCPGVAPEVTEGAKGLEDTEEPEEE-----------EEGEEPNYPLELLYCLYETQE-DA
FVRQALCG---------------------L-------------------PELALQRVRFC
RM-DVAVL--S----YCVR-CCPA-GQA-LRLI------------------SC----RLV
------AA----------------------------------------QEK--K---KKS
----------------------------------------LGKR----------------
------LQAS---L--------------GGS------S-----------------SRGTT
KQ---LPAS-------LLHPLFQAMTDPLCH----LSSL--------TLS---------H
C-----------------------------------------------------------
--------KLP---DA-VCR---DLSEALRA-APALTELGLLHNRLS-EAGLRMLTEG--
-LAWPQCRVQTV------------------------------------------------
----------------------------RVQ-----------------------------
---------------LPDP---------QRGLQYL-------------------------
------------------------------VSVLRQSPALTT---LD-LSGC-QLPAPMV
--T--------YLCAVL----QHQGCGLQTLSL--ASVELSEQ-----------------
----------SLQELQAVKRAKP-------DLV----------------------I--TH
PALD-------------------GHPQPP-KELISTF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------INPYKKH-
--------MKEK----------------FRLI-------WKNEAC---------------
----------------LQVP------E-----CFYKE-------VTNNEFEELHDAYNA-
EE--FRQRS----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

LTVAMQGPRGVGKTTFLRRV-----MLEWA--E---------GNFCK
D--------RFTF-VFFLDARGLNHVK-------EASLVE-LISR-DW-----PE-CSEP
IEDIFS-QP----QKILFIIDGFEE-LKFDLELY-------T-N-----LCHDWTQQ-QP
-MPIVLSSLLQKKMLPESSLLIA-LGTVGMQKNHFLL-K-----HPK--YIRLVGLSEHE
RELYF----------------S--HF-FCE---------KKKVLQALSFVRD-NSPLFSI
CQSPLLCWLICTCMN-QLERGE-DF-E--IS-WQTTTSLYASFFTNVFNRGE-XXXXXXX
XXXXXXXXXXX----XXX-XXXXX---XXXX-XX-XXXXXXXXXXXX-------------
--XXXXXXXX-XXXXXXXXXX----XXXXXX-X-XX-X-XX-XXXXXXXXXXXXXXXXX-
XXXXX----------------XX--XXXXX-------XX-XXX--XXXXXXXXXXX----
----XXXXXXXXXXXXXXXXXXX---------------X--XXX----------------
XXX-----X-----XXXXXX-X---------------XXXXXXXXXXXXXXXXXXXX-XX
XX-XXXXX---------------------X-------------------XXXXX-XXXXX
XX-X-XXX--X--------XXXXX-XXX-XXXX----------------XX---------
----XXXX----XX---------------------------XXXXXX----XXXXH-NER
LGLWRDLC-SVFSTSKDLQVLELDNCSLDGA---------SLAILC--KALAQ-P-----
TC--T-LQRL--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
---MLI----------------------SVGRLHPGRESCLSTPRTKGQRPPL-------
-------------FIRSLCRKHR------------LEARP----DLREF------FSL-N
L---RSHTRSTMTSP----QLEWT---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LQTLLEQLN--E---DELKSFKSLLWA------
---------F--PLEDV--------L--QKT-PWSE-VEEAD-GKKLAEILVNTSSENWI
RNATVNI----LE-EMNLTELCKMAK--AEM-----------------------------
------------------------------------------------------------
--MEDG---------------------------------QVQEIDNPEL-----------
-------GDA-------------------------------EEDSELAKPGEKEGWRNS-
---------MEK----------------QSSV--WKNTFWQGDIDNFHDAVT--------
-----------------------------------------------LRNQRFIPFLNPR
TP--GKLTP----Y

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLHGPAGVGKTTLAKKC-----MLDWT--D---------CNLSP
---------TVRY-AFYLSCKELSRMG-------PCSFAE-LISK-DW-----PE-LQDD
IPSILA-QA----QRILFVVDGLDE-LKVPPG------ALIQ-D-----ICGDWEKK-KP
-VPVLLGSLLKRKMLPKAALLVT-TRPRALRDLQLLA-Q-----QPI--YVRVEGFLEED
RRAYF----------------L--RH-FGD---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DP-V--PT-CLTRTGLFLRFLCSRFPQG-------AQ
------------LRGALRTLSLLA---AQGL-WA-QM----SVFHRE-------------
--DLERLGVQES-DLRLFLDG----DILRQDRV-SK-GCYSFIHLSFQQFFAALFYALE-
KE--E---EE--------DRDGH--TSDIGDVQ-KLLSGEERL-KNPDLIQVGHFL----
----FGLANEKRAKELEATFGCR---------------M--SPD-IKQ-ELLRCKAHLHA
NK-----------------------------------S-LSVTDLREVLGCLYESQE-EE
LAKVVVAP---------------------L-------------------KEISIHLTNTS
EV---RHC--S----FSLK-HCQD-LQK-LSLQ----------------VAKG----VFL
-ENY-MDF----EL--------------------DIEFERC-TYL--TIPTWARQD-LRS
LRLWTDFC-SLFSSNSNLKFLEVKQSFLSDS---------SVRILC--DHVTR-S-----
TC--H-LQKVE--I-KNVTPD--TA----YR-DFCLAF----------------IGKKTL
THLT-LAGH-IEWERTMMLMLCDLLRNRKCN----LQYL--------RLG---------G
H------C----------------------------------------------------
---------AT---PE-QWA---EFFYVLKA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1795)

NQSLKHLRLSANVLLD-EGAMLLYKT--
MTR-PKHFLQML-S----------------------------------------------
------------------------LENCRLT-----------------------------
----------------------------EASCKDLAA-----------------------
--------------------------------VLVVS

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

KKLTH---LC-LAKNP-IGD---
-------TGVKFLCEGL----SYPDC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LQQCSITKLGCRYLSEA-LQEACSLTNLD
L-SVNQIA-RGLW-ILCQALENP--NCN----L---------------------------
-----------------------KHLRL--WSC-----SLMPFYCQHL------------
-------GSAL-L

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2377)

SNQKLETLDLGQNHLWKSGIIK-LFGVLR-QR-TG-SLKTLR--LK-
--T-YETNLEVKK--------------------LLEEVKEKNPKLTIDCNAS------GA
---------------TAPPCCD--FF----------------------------------
----C-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------S

PF02758 // ENSGT00900000140813_0_Domain_0 (201, 328)

LRCR---LVRYLEELT--N---EEFKKFKLYLED------
---------T--SPREG--------A--LRI-PRGQ-VKKAD-STDMAELMVHHYGEWES
WEVALMI----WE-KMGLRELWEQAK-RESPQIXX-----XXXXXX------XXXXXXX-
------------------------------------------------------------
------------------------------------------XXXXXXX-----------
XXXXXX-XXX-------------------------------XXXXXXXXXXYKEKYRDQ-
--------VRKK----------------FQVL--VERNARLGEWV---------YLSHHY
TRLLLVSGHASPGSREQELL------ASGM---GISG-----R-SVEPI--ELQALFDAD
KG----EAV----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

PTVVLLGIAGIGKTTLARKV-----LLDWA--L---------GTFYP
G--------QFDY-AFYVNCRTVDVAAQ-------RTVAELLLSW-LE-GTGPAS-GAAP
VSSMLA-QP----ERLLFVLDGFDE-SGHWGPAW------VP-----------REEK-QR
-VDVHLRNLLGKRLLPESSLLIT-TRPMALEKLQQLL-E-----QPR--VARVLGFRALE
RKAYF----------------Y--RY-FPD---------PGQAGRAWATVQA-NEVLFAL
CFVPLVCWTVCTGLRQQMERGE-AL-A--QT-GRTTTAVYTAFLSSLLHPDRPT------
-----------QESANLWGLCSLA---ATGQ-QE-QR----LWFREQ-------------
--DLVRHGLDMATVS-TFLHM----DQFQDEAK-CE-AIYSFFHSTFQEFFAALFLVLK-
QLGGPS----------------------------VVLAENCRL-AEADLPLTIRFL----
----FGLSSRERAGTLEKMVGGP-----------------VPQR-SQR-ILLKWIRAQAA
Q-------------------------------------RPRQTKTLELLYCLFETQE-PE
FVRSAMAC---------------------F-------------------REVKVRVCT-R
-M-DGLVV--A----FCXX-XXXX-XXX-XXXXXXXXXXXX--XXXXXXXXXX----XXX
XXXXXXXXXX---XXX--XX------------------XXXXX-----------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------XXXX-------X--------XXX---------X
XXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX--XXXXXXX--X-XXXXXXXXXX
XXXXXXXXXXX--XXXXXXX---XXXXXXXX--------------------------X--
XXX-XXXXXXXX-X----------------------------------------------
------------------------XXXXXXX-----------------------------
----------------------------XXXXXXXXXXXXX-------------------
------------------------------XXXXXXXXXXXX---XXXXXXXX-XXXX--
-------XXXXXXXXXX----XXXXX----------------------------------
--------------------------XXX-XXX---------------------------
-------------------------------XXXXXXXXXXXXX------------XXXX
X-XXXXXXXXXXX-----XX----------------------------------------
---------------------------X--XXX-----XXXXXXXXXX------------
-------XXXX-XXXXXXXXXXWWQHLSTFGSLSL-QTLGEF-NN-DLGVLR-VL--GG-
----EV---LEQQSWWHL------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAMTKA-RNPREA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALSDLE--E---NDFKKLKFYLRD------
---------M--TLSE--------------------------------ELLISKYGEKEA
VTVVLKG----LR-VMNLLELVDQLS-HIC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LH--DYREIYREH-
--------VHC-----------------IE------EW---QEA----------GVNGRY
SQVLLVA-KSSSESPES-AH------PI-------PE-----Q-ELDSV--MVEALFDSG
EK--PSLAP----S

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

LVVLQGSAGTGKTTLARKM-----VLDWA--T---------GSLYP
G--------RFDY-VFYVSCKEVVLLLE-------SKLEQ-LLFW-CC-GD-----NQAP
VTEILR-QP----EWLLFILDGFDE-LQRPFEEK------LK-K-----RG-----L-SP
-KESLLHLLIRRHTLPTCSLLIT-TRPLALRNLEPLL-I-----QAR--HVHILGFSEEE
RARYF----------------S--SY-FTD---------EKKADSAFDIVQK-NDILYKA
CQVPGICWVVCSWLKGQMERGK-AV-------------------STFLPPVD-DGGCSEF
----------S-RHRVLRSLCSLA---AEGI-QN-QR----FLFEEA-------------
--ELRKHNLDGPRLA-AFLSS----NDYQLGLA-IK-KFYSFRHISFQDFFHAMSYLVK-
EDQSRL----------------G--KESRRELQ-RLLEAKEQE-GNDEMTVTMQFL----
----LDISKKDSFLNLELKFCCR-----------------MSPC-LAQ-DL-KHFKEQM-
E-------------------------------------SMKHNRTWDLEFSLYEAKI-KN
LVKGIQMK---------------------D-------------------VSFKIKHSN-E
KK-SQSQN--S----FSVK-SSLS-HGP-KEEQ------------------KR----PSV
---RGQKEGK---DNI--A-------------------GTHKE-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AST----------------GKG---------R
-GTGE-TDEEVRS-PKN--TYI--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 940)

VVLQGCAGIGKTAVVHKF-----MFDWA--A---------AMVSR
G--------RFDY-LIYVTCRERSHIA-------NLSAAD-LIIN-TF-----QD-IDGP
ILDIILVYP----EKLLFILDGFPE-LQYLVGNQ------EE-D-----LSANPQEK-KP
-VETLLCSFVRKKLFPESSLLIT-ARPTTMKQLHSLL-K-----QPI--QAEIVWFTEAE
KRAYF----------------L--SQ-FSG---------ADAAMGVFYELRQ-NESLDIM
SFLPIISWMIC----PQGDGDR-TL-M--RS-LQTMTDVYLFYFSECLKTLTGIS-VW--
-----------KGQSCLWGLCSLA---AEGL-RN-HQ----VLFEVS-------------
--DLRRHGIGVYDINCTFLNH-----FLKKTEK-SV-NVYTFLHFSFQEFLTAVFYTLK-
NDSSW---------------------MFFDQVGKTWQEIFQQY-GKGFSSLTIQFL----
----FGLLHKGKGKAVETTFGRR---------------V--SP------ELLKWTEKEIK
DK-----------------------------------SSRLQIEPTDLFHCLYEIQE-EM
FLKSVLSA---------------------C-------------------QSTSGVH----
------------------------------------------------------------
--RH----------------------------KP--------------------------
---------PCFQ-----------------------------ALHC--TAQI--------
CS--K-IKK---------------------------------------------------
KDIN-EPRD-ISENA-GHKYT-----NSVCV----------------------------C
VH------------YI----SKTLSTSQWLTDLEFSETKLEASALKLLCEDLKDPNCK-L
QKLNDN------NIEY-ICGFIYFFLTVLIC-NP

PF00560 // ENSGT00900000140813_0_Domain_8 (1775, 1805)

NLTELDLSENPLGD-TGVKYLCEG--
LRH-SNCKVEKL-D----------------------------------------------
------------------------LSTCYLT-----------------------------
----------------------------DASCMELSS-----------------------
--------------------------------FLQVSQTLKE---LF-VFASA-LGD---
-------TGVQHLCEGL----RHAKGILENL-----------------------------
------------------------------------------------------------
------------------------------VLSECSLSAACCESLAQV-LSSTRSLTRLL
L-INNKIEDLGLK-LLCEGLKQP--DCQ----L---------------------------
-----------------------KDLAL--WNC-----HLTGECCQDL------------
-------CNAL-YTNEYLRDLDLSDNALGNGGMQV-LCEGLK-HP-SC-KLHTLW--LA-
--E-CHLTDACCG--------------------ALASVLNRNE

PF00560 // ENSGT00900000140813_0_Domain_17 (2444, 2475)

NL-TLLDLSGNDLKDFG
VQMLCD--------SLIQPICK--L-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MDGPEASCPSMGPR--AAVAREL---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLAALEDLS--Q---EQLKRFRHKLRD------
------------SLADG-----------RSI-PWGR-LELAD-AVDLAEQLTNFYGPEPA
LDVARKT----LK-RADVRDVAARLK-EQRLQR---------L---------GRS-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SS-ALLSLSEYKKKYREH-
--------VLRQ----------------HAKV--KERNARS------------VKISKRF
TKLLIAAESGALEEE--ALGPAE-------APEP--------QRARRSDTHTFSRLYRRD
K---EGQRP----L

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGPAGIGKTMAAKKI-----LYDWA--A---------GKLYQ
S--------QVDF-AFFMPCGELLERPG------ARSLAD-LILD-QC-----PD-RGAP
VQQMLG-QP----QRLLFILDGADE-LPAPDAP--------EAA-----PCTDPFEA-TS
-GARVLCGLLNKALLPTARLLVT-ARASAPGRLQGRL-C-----SPQ--CAEVCGFSDKD
KKKYF----------------Y--KF-FQD---------EWRAERAYRFVKE-NETLFAL
CFVPFVCWIVCTVLRQQLELGR-DL-S--RT-SKTTTAMYLLFIASVLSSAPAADRP---
-----------RVQGELRKLCRLA---REGVLGH--R----AQFAEK-------------
--DLERLELRGSKVQTLFLSKKELPGVLET-----E-VTYQFTDQSFQEFFAALSYLLE-
DEGSP-------------------G-GEAGGLG-TLLRGDAQL--RHYLALTTRFL----
----FGLLSAERMRDIEHHFGC-----------------VVSER-VKQ-HALRWVQGQGC
PR-----ATPEGTEVLEDKEEPEE-E---------E-EEEELNYPLELLYCLYESQE-DA
FVRQALGS---------------------F-------------------PELALERVSFS
RM-DIAVL--S----YCVR-CCPT-GQA-LRLV------------------SC----RLA
------AA----------------------------------------QK-R-K---KKS
----------------------------------------LVKR----------------
------LQGH---L--------------GSS------S----------------SSRATT
KQ---LPPS-------SLCPLFEAMTDQQCG----LTSL--------TFS---------H
C-----------------------------------------------------------
--------KLP---DT-VCR---DLSEALRA-APALTELSLLHCRLS-EVGLRLLSEG--
-LAWPQCRVQTL------------------------------------------------
----------------------------RLQ-----------------------------
---------------LPGP---------QGALQYL-------------------------
------------------------------VAMLRQSPALTT---LD-LSGC-QLPGSMV
--T--------YLCAVL----QHPACSLQTLSL--TSVELSEG-----------------
----------SVQELQAVKTEKP-------DLV----------------------I--MH
PALD-------------------SRPEPPAGLSRAL------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MS------------------
----------FSVTTWEDGGTNQG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LLPYLVALD--Q---YQLEEFKLCLEPRQLMDF
WSA----------PQGH--------F--PHI-PWAN-LRAAD-PLNLSFLLDEHFPKGQA
WKVVLGI----FQ-TMNLTSLCEEVR-AKMKGNVH-TQELQGPTQE------DVEMLEAA
----AGNMQTQGCQ-----------------------D----------PNQEEPEELE--
E-----------------------ETGNV----------QVQGCQDPNQ-----------
------EEPE-------------------------------MLEEA----DHRRKYREK-
--------MKAK----------------LLET--WDNIDWPKDHVYIRNTSE--------
----------------------------------------------G-EHEELQRLLDPK
R---TRTQA----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TTVLVGRAGVGKTTLAMQV-----MLHWA--N---------GVLFQ
Q--------RFSY-VFFLSCHKIRYMK-------ETTFAE-LISL-DW-----PD-SDAP
IEEFMS-QP----EKLLFIIDGFEE-IIISEPSS--ESLDDG-S-----PCTDWYQE-LP
-VTKILLSLVKKELVPLATLLIT-IKTCFVTDLKPSL-V-----NPC--FVQITGFTGED
LWVYF----------------M--RH-FED---------SREVEKILQQIRK-NENLLHS
CSAPMVCWTVCSCLKQSKVRYY-DL-Q--SI-TQTTTSLYAYFFSNLFSTAE-VDLADES
------------WPGQWRALCNLA---KEGL-WS-MN----FTFDRE-------------
--DTELEGLEVP-FIDCLYKF----NILQKGND-CR-DCITFTHLSFQEFFAAMSFVLE-
EPREL--------------L-PH--STKPQEMK-ILLRDVLLN-KEAYWTPVVLFF----
----FGLLKKNLARELEDTLHCK---------------M--SPR-VTE-ELLKWGEELVK
AE-----------------------------------SASLQFHVLQLFHCLHESQE-ED
FANKMLGH---------------------I-------------------FEVDLNILGDE
DL---QAA--S----FCLK-HCKR-LDK-LRLS----------------VGS-----HIL
-ERDLEIL----ET--------------------------------------S-EV-DSR
MHAWNSIC-STLVTNENLHELDLSNSKLHAS---------SVKGLC--LALKN-P-----
RC--N-VQKLT--C-KSVTPE--WV---L-Q-DLILVL----------------QG

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1633)

NSKL
THLN-FSSN-KLGAT-V-PLILKALKHSACN----LKYL--------CL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------EKCNLS-----------------------------
----------------------------AASCQDLAL-----------------------
--------------------------------FLTSI

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

QHVTR---LC-LGFNQ-LQD---
-------DGIKLLCAAL----THPKC----------------------------------
--------------------------ALE-RLE---------------------------
-------------------------------LWFCQLGAPSCRYLSDA-LL

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

QNRSLAHLN
L-SKNRLGDEGVK-FL

ENSGT00900000140813_0_Linker_13_14 (2237, 2247)

CEALGHP--D

PF13516 // ENSGT00900000140813_0_Domain_14 (2247, 2348)

CN----L---------------------------
-----------------------QSLNL--SGC-----SFTREGCQEL------------
-------

ENSGT00900000140813_0_Linker_14_15 (2348, 2354)

ANAL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNHNVKILDLGQNDLQDDGVKL-LCEALK-PS-HR-ALHTLG--LA-
--K-CNVTTACCQ--------------------HLSSVLSSSKSL-VNLNLLGNELDPDG
VKMLCK--------ALRKSTCR--LQ--K-------------------------------
---LG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MAMTKA-RNPREA---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWALSDLE--E---NDFKKLKFYLRD------
---------M--TLSEG--------Q--PPL-ARGE-LEGLI-PVDLAELLISKYGEKEA
VTVVLKG----LR-VRNLLELVDQLS-HVC------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LH--DYREIYREH-
--------VRC-----------------IE------EW---QEA----------GVNGRY
NQVLLVA-KSSSESPESSAH------PI-------PE-----Q-ELDSV--MVEALFDSG
EK--PSLAP----SL----

PF05729 // ENSGT00900000140813_0_Domain_2 (680, 940)

GSAGTGKTTLTRKM-----VLDWA--T---------GSLYP
G--------RFDY-VFYVSCKEGVLLLE-------SKLEP-LLFW-CC-GD-----NQAP
VTEILR-QP----ERLLFILDGFGE-LQRPFEEK------LK-K-----RG-----L-SS
-KESLLHLLIRRHTLPTCSLLIT-TRPLALRNLEPLL-K-----QAG--HVHILGFSEEE
RARYF----------------S--SY-FTD---------EKKADSAFDIVQK-NDILYKA
CQVPGICWVVCSWLKGQMERGK-AV-L--ET-PRNSTDIFMAYVSTFLPPVD-DGGCSEF
----------S-RHRVLRSLCSLA---AEGI-QN-QR----FLFEEA-------------
--ELRKHNLDGPRLA-AFLSS----NDYQLGLA-IK-KFYSFRHISFQDFFHAMSYLVK-
EDQSRL----------------G--KESHREVQ-RLLE----------MTLTMQFL----
----LDISKKDSFLNLELKFCCR-----------------ISPC-LAQ-DL-KHFKEQM-
E-------------------------------------SMKHNRTWDLEFSLYEAKI-KN
LVKGIQMK---------------------D-------------------VSFKIKHSN-E
KK-SQSQN--S----FSVK-SSLS-HGP-KDEQ------------------KR----PSV
---RGQKEGK---DNI--A-------------------GTHKE-----------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AST----------------GKG---------R
-GTEE-A-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------LVTLPTGPVHSTLPKNP------------L-------------------FHQ-N
L---SFQSCIRMAEDKLPAFSIDG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LQWCLKELD--K---EEFQTFKELLKK------
---------K--SSELT--------K--SSI-PLVE-VVNAD-VEHLAFLLHEYYTGPHA
WEMSINI----FE-EMNLPTLSEKAK-DEMKKHSV-AEIPGDFEPIKT--DQGPSKEEGS
EIS-QAMEIDG----A------------------------TEAE---TEKQEISQAIE--
QG-GATAA---------ETKEQV-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RK-----SIS
-KDE--EA----WS--------------------VI-----------PR--RVWGK-GLI
DQQWETFC-RVLCNHRNLQHLDLGTSILTEW---------AMKKLC--AELKS-P-----
TC--T-VQNLV--F-RDTQI---MA---GLQ-HLWLTL----------------I

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1640)

SNHHI
KCLN-LGST-LLKDE-DVKAACEALKHPNCF----LESL--------RLD---------L
C------A----------------------------------------------------
---------IS---QA-GYL---MISQVLTTRS

PF13516 // ENSGT00900000140813_0_Domain_8 (1774, 1795)

ISLNYLGLAGNKVTD-EGVKPLFEA--
LKA-PQCTLQKL-T----------------------------------------------
------------------------LESCSLT-----------------------------
----------------------------AVGCHALAS-----------------------
--------------------------------ALD

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNRSLTH---LC-LSSNH-LGI---
-------EGMYMLCQSI----RLPSC----------------------------------
--------------------------SLR-RLI---------------------------
-------------------------------LNQCGVNVDTCDFLVIA-MMG

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NTLLTHLS
L-NWNPLQDEGVN-LLCKVMLKT--WCQ----L---------------------------
-----------------------QDLEL--VGC-----HLTAACCTNL------------
-------SSVI-TR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

SKHLKSLDLASNAVGDSGVAV-LCEGLK-HE-KG-SLRRLG--LQ-
--A-CGLTSNCCE--------------------VLSSTLSC

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NQSL-TSLNLVQNSFSPEG
MVKLCS--------AFAHPLCS--LQ--V-------------------------------
---IGLWKC-QYPVQVQKL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------EKYQNQ-
--------KRES----------------SCPTQSW-------RNE---------YLHQKF
TQLLLIRRSQPRGYDF---L------LRRRRNHEV--------VDEQRHLMEIGHLFGPG
LR--TRKEP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

PTVVVHGVAGIGKSTLARQV-----RRAWE--E---------DWQFR
D--------RFKH-VFYFNCRELAQSK-------TMSLAE-LITK-DW-----AA-PDAP
IGQILS-QP----EQLLFILDNLDE-PKWDLKKQ------SS-A-----LCPHWSQQ-QQ
-VHTLLGSLLKKTLLPTASLLIT-ARITALRKLIPSL-K-----HPR--WVEVLGFSESA
RKEYF----------------F--QY-FID---------ESQAIRAFTSVES-NPALFTM
CLMPLVSWLVCTCLKQQMEQEQ-PL-S--LT-SQTTTALFLHYFFHVLQ--------AQ-
-----------SLGAKLRGLCSLA---AKGT-CQ-RK----TLFSPE-------------
--DFRKYRIDEA-NIPILLNM----GVLQEH---PTLRSYSFLHRCFQEFFAAMSYASG-
D------RKL--------KRGGF--INI-KTIT-DLTDVYDRR--DLFGEPTTCFL----
----FGLLSDQGMRELESIFKRS---------------L--SRK-RHS-YLLQLAQREVD
-----------------------------------CKHPNLEPYCWHLLHCFYENQD-TR
FLTEMMSN---------------------F-------------------YGMRICVQTHM
EL---LVF--T----FCFK-FCHR-MMT-LQLN----------------DGGE-------
------K-K---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------L------------
------AQSP--------------------------------------------------
-------------------SDVVLYSWGPFT-----------------------------
----------------------------DSWWQMFFS-----------------------
--------------------------------ILKVPG

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2057)

SLRE---LD-LSGNY-LSC---
-------SAVKSLCDAL----KSPHCRLETLT----------------------------
------------------------------------------------------------
-------------------------------LVSCGL-----------------------
------------------------------------------------------------
----------------------------------------TS------------------
------------------------------------------------------------
---------GCCQ--------------------DLVSMLSNNIML-SELDLRQNDLGNLG
VRLLSE--------GLRQSNCR--LK--Y-------------------------------
---LWLDGT-QLSAEVTEM------LR----------LLQ-QDKSHLVISY-EWALRRIA
QMDEMDEETTPLQ-----------------R-----------------------------
----------------------------QEPESEPLGD---IPVSSIG-TDDDFWGPTGP
VTPEVGDE-DRGLYRVHFPVAGSYHWP---NTGIYFVVRGPV-------TIEIEFCAWDQ
FLDQIVPQHSWMVAGPLFDIKAEPGA-VEAVYLPHFIALQEE--------HVDISWFQVA
HFKEDGILLEKPTMVEPHYIVLENPSFSPMGVLLRKIHSFLN-IPVISNVLLYHRLHSEE
V-NFHLYLLPSDCTIEKAVDIEKKKFQFVRIHKPPPLTPLHIGSRYIVSGS---------
QKMEIIPEELELCYRSPGKAQLFSEFYVDHLGSGIRLQIKSKNDETVVWEALVKSGDLRP
AAPLVS-----------------------------QALTASPSSPNAPNL

PF00619 // ENSGT00900000140813_0_Domain_19 (3051, 3135)

LHFVDQHRAQ
LVARVTSVDAVLDKLH-GPVLSDEQYERVRAEPTNPDRMRKLFSIIKSCDWACKDQLYRA
LKEIHPHLIEELLEK---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------SSQTAG--
HDGGAEGT---------Q--EQXXXXXXXXXXXXX------XXXXXXXX----------X
-----X---X-------------------------------XXXXXXXXXXXXXXXXXX-
--------XXXX----------------XXXX--XXXX-X--------------------
--------------------------------------------XXXXX-XXXXXXXXXX
X---XXXXX----XXXXXXXXXXXXXXXXXXXX-----X-XXX--X---------XXXXX
X--------X-XX-XXXXXXXX---XX-------XXXXXX-XXXX-XX-----XX-XXXX
XXXXXX-XX----XXXXXXXXXXXX-XXXXXXXX------XX-X-----XXXXXXXX-XX
-XXXXXXXXXXQVLLPGCFLVVT-IRNADLAKLQP-L-T-----APL--YLAMSGLSVQR
RIQLL----------------Q--EH-VPN---------EQGKMQVLHSVMD-NHQLFDQ
CQVSTVCLLVCRALELQEATGN-SAGA--PG-CQTLTALYAAFVFHQLAPEG-VLQHCLG
----------RPERAMLLGLCRLA---AESV-WA-KR----SVFHAE-------------
--ELRALGLSDE-ELSAPPLM----SVLLPANRNHAEERYAFLHLSLRDFFAALYYVLE-
GLGSL--------------PAPC--SLQSPGTG-----RSSAD-RRPHPLGMKRFL----
----FGLMSQEVLRALEVLLGCA---------------V--PQGTARQ-ELTSWISLLGL
QAG----------------------------------TL-APESAMESFYCLFETQD-KE
FVLLALDS---------------------F-------------------QDLWLRVSQKM
DL---IVS--S----FCLQ-CCRH-LRK-IRVD----------------VRD-----LFL
-KEEIP-T----WP--------------------RI-----------PQ--WMQCK-TIV
DEWWENFC-SVLATHPQLQQLDLGHSILNEW---------AMKMLC--AKLRH-P-----
TC--K-IQRLX--X-XXXXXX--XX---XXX-XXXXXX----------------X-XXXX
XXXX-XXXX-XXXXX-XXXXXXXXXXXXXXX----XXXX--------XLD---------F
C------G----------------------------------------------------
---------LN---QS-CCL---MISQVLHK-STSLKILGMAGNKVTD-WGLKVLCDA--
LRP-SWCALRRL-T----------------------------------------------
------------------------LEDCGLM-----------------------------
----------------------------ATSCHILAL-----------------------
--------------------------------ALTNNR

PF00560 // ENSGT00900000140813_0_Domain_9 (2019, 2132)

SLTH---LC-LSRNP-LDP---
-------EGLSPLCRAI------PDS----------------------------------
--------------------------SLQ-RLV---------------------------
-------------------------------LNHCGLDIAGCGYLVFA-LRDNRQLTHLS
L-SQNPLGDSGIK-LLYEAMREL--SCH----L---------------------------
-----------------------QDLEV--AGC-----QLTAACCESL------------
-------SHMI-MRSK

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2381)

HLKSLDLGSNALGDSGVAA-LCEGLK-QR-SS-ALQRLG--XX-
--X-XXXXXXXXX--------------------XXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXX--------XXXXXXXX--XX--X-------------------------------
---XXLCKE-QYPEETRKL------LE----------GVQ-HAKPHVVIDGDWYSHD---
--E---------------------------------------------------------
--------------------------------------------------EDQHWWRS--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MAESNSDFD---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWYLENLS--D---KEFQSFKKYLAR------
---------K--ILDFK--------L--PQV-PLIN-LRA-T-KEELANLLPISYEGQHI
WNMLYSI----FL-MMRKEDHCMKI---IGRRN---------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RNQEACKAL-
--------MRRK----------------LMLR--WENHTFGEFHYKFFCNVA--------
----------------------------------------------SDVFYVLQLAYDST
SC--YSAND----LN

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 930)

VFLMGDRASGKTMTINLA-----VMKWI--N---------GEMWQ
N--------MISY-VVHLTSHEINQMT-------DSSLAE-LIAK-DW-----PD-GQAP
IADILS-DP----KKLLFILEDVDN-LRFELNVN------EQ-A-----LCSNSTQK-VP
-IPILLVSLLKRQMAPGCWFLIS-SRPTREENIKMFL-K-----TTD--CYVTLQFSNEK
RELYF----------------H--SF-FND---------RQRASTALMLVHD-DEILTGL
CRVAILCWITCTVLNRQMDKG-HDP-Q--HC-CETPTDLHAHFLADALTSKAGLT-AN--
----------QYHLGLLRRLCLLA---AGGL-FL-ST----LNFSGE-------------
--DLRCVGFTEV-DVSVLQAV----NILLPSST-HK-DRYKFIHLNVQEFCAAIAFLMAV
PNCLI-----------------P----SGSR-G--Y--KEKRE-QYCNFNQVFTFI----
----FGLLNENRRKILETTFGYQ---------------LPMVDS-FRR-YSVEYMKHLGR
DQ-------------------------------------EKLTHHGSLFYCLFENQE-EE
FVKKVVNT---------------------L-------------------KEVTVYLQSNK
DM---MVS--L----YCLE-YCCH-LRT-FKLS----------------VQR-----IFE
--YKEPLV-------------------------------------------RPTASQMKS
LVYWREIC-SLFCTMDTLWELHLFDSDLNDI---------SERILS--KALEHS------
SC--K-LRTLKLSY---------IST-ASGFEDLLKAL----------------ARNRSL
IHLS-LNCT---------------------------------------------------
------------------------------------------------------------
--------------------------------------------SISL-NMFSLLREI--
LDK-STCQIRHL-S----------------------------------------------
------------------------LMKCDLR-----------------------------
----------------------------ASECGEIAS-----------------------
--------------------------------LLVNGGSLRK---LT-LTNNP-LRN---
-------DGVNILCNAL----LHPNCTLTSL-----------------------------
------------------------------------------------------------
------------------------------ALVFCCLTEKCCSSLGRV-LLLGRTLKQLD
L-CVNHLQNYGVL-HVTFPLIFP--TCQ----L---------------------------
-----------------------EELYL--SGC-----FFTNDICQYI------------
-------AIVIA-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NETLRSLEIGSNSIEDAGMQL-LCGGLR-HP-DC-MLVNIG--LE-
--E-CMLTGACCE--------------------SLASVLT

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2464)

TNKTL-ERLNILQNQLGDEG
VVKLLE--------SLILPECV--LQ--I-------------------------------
---IGLPLN-DVSAETRRM------VM----------TVK-ERKPNLIFLSETWSVKEGR
EIGVI-------------------------------------------------------
-------------------------------------------------------PASQP
GSV-----------------IPNSNLD---YM--FFKFPRMSTAMRMSSTASRQPL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MNN---------------------------QKKRKDMEPA-----
--------CTWS------------------------------------------LLSE--
-----------------------------------------KR-----------------
----VASSSL-------------------------------ASFSWRELTDYREVFRKH-
--------LKEK----------------YLKI-GVDKCYHHGK--------------HIE
SRLLLVKEHGISEKTPCGIP-------------------------QQDHFIEMEHIFDPD
EE--GSSSS----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 929)

RTVVLQGCAGSGKTAVVHKF-----MFDWA--A---------GMVTP
G--------RFDY-LIYVNCREISHIA-------NLSAAD-LITN-TF-----QD-INGP
ILDIILIYP----EKLLFILDGFPE-LQYPVGDR------EE-D-----LSAHPHER-KP
-VESLLCSFVRKKLFPESSLLIT-ARPTAMKKLHSLL-K-----QPI--QAEILWFTDAE
KKAYF----------------L--SQ-FSG---------ANAAMKVFYGLRE-NEGLDIM
SSLPIVSWMICSVLQSQGDGDR-TL-L--RS-LQTMTDVYLFYFSKCLKTLTGIS-VW--
-----------KGQSCLWGLCSLA---AEGL-QN-HQ----VLFAVS-------------
--DLRRHGIGVYDSNCAFLNH-----FLKKAEG-DI-NVYTFLHFSFQEFLTAVFYALK-
NDNSW---------------------MFFDQVGKTWQEIFQQY-GKGFSSLMIQFL----
----FGLLHKGKGKAVETTFGRK---------------I--SPG-LRE-ELLKWTEREIK
DK-----------------------------------SSRLQIEPVDLFHCLYEIQE-EE
YSKKIIDD---------------------L-------------------QSVILLQPTYT
KM-DILAM--S----FCVK-SSHSHLS----------------V-----SLKCQHLPGF-
-EEEEPAS----------------------AFVP--------------------------
---------PALTLNESCQ-----LHNLPVS---------RLHLLC--QALRNP------
YC--K-IKDLKL---IFCHLT------ASCGRD---------------LSAVFET

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1642)

-NQYL
TDLE-FVKN-TLEDS-GMKFLCEGLKQPNCI----LQTLR--------LYRCLI-SPA-S
CG------------AL----AAVLSTNQWLTELEFSETKLEASALKLLCEGLKDPNCK-L
QKLKLCASLLPESSEA-VCK---YLASVLIC-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NPHLTELDLSENPLGD-RGVKYLCEG--
LRH-SNCKVEKL-D----------------------------------------------
------------------------LSTCYLT-----------------------------
----------------------------DASCVELSS-----------------------
--------------------------------FLQMSQTLKE---LF-VFANA-LGD---
-------TGVQHLCEGL----KHAKGIIENL-----------------------------
------------------------------------------------------------
------------------------------VLSECSLSAACCEPLAQV-LSSTRSLTRLL
L-INNKIEDLGLK-LLCEGLKQP--DCQ----L---------------------------
-----------------------KDLAL--WTC-----HLTGACCQDL------------
-------CSAL-Y

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

TNEHLRVLDLSDNALGDEGMQV-LCEGLK-HP-CC-KLQTLW--LA-
--E-CHLTDACCG--------------------ALASVLNR

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NENL-ILLDLSGNDLRDFG
VQTLCD--------ALIHPICK--LQTFY-------------------------------
------IDTDHLHEDTFRK------ME----------ALK-MSKPGITW-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSLDIQCEQ-LSD-ARWT----------------EL---------
----LPLI-------------------------------QQYEVV------RLDDC-GLT
EVRCKDIS-SAVQA

PF13516 // ENSGT00900000140813_0_Domain_4 (1515, 1542)

NPALTELSLRTNELGDA---------GVGLVF--QGLQS-P-----
TC--K-IQKLS--L-QNCGLT--EA---GCG-ILPGML----------------RS

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

LSTL
RELH-LNDN-PMGDA-GLKLLCEGLQDPQCR----LEKL--------QLE---------Y
C------N----------------------------------------------------
---------LT---AT-SCE---PLASVLRV-KADFKELVLSNNDLHE-AGVRILCQG--
LKD-SACQLESL-K----------------------------------------------
------------------------LENCGIT-----------------------------
----------------------------SANCKDLCD-----------------------
--------------------------------VVASK

PF13516 // ENSGT00900000140813_0_Domain_11 (2018, 2054)

ASLQE---LD-LGSNK-LGN---
-------AGIAALCPGL----LLPSC----------------------------------
--------------------------KLR-TLW---------------------------
-------------------------------LWECDITAEGCKDLCRV-LRAKE

PF13516 // ENSGT00900000140813_0_Domain_13 (2215, 2237)

SLKELS
L-ASNELKDEGAR-LLCESLLEP--GCQ----L---------------------------
-----------------------ESLWV--KTC-----SLTAASCPYF------------
-------CSVL-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNRSLLELQLSSNPLGDAGVQE-LCKALG-QP-DT-VLRDLW--LG-
--D-CDVTNSGCS--------------------SLANVLLA

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2464)

NRSL-RELDLSNNLMGGHG
VLQLLE--------SLKQPSCA--LQ--Q-------------------------------
---LVLYDI-YWTNEVENQ------LR----------ALE-EQRPSLRIIS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MEETHGYN---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 321)

LTLCLLKLS--D---EDFMEFKDSLRK------
---------V---LGFK--------P--KPI-PRTK-IATAS-RRGLAMLLNKHYPGQ-V
WDIVLSL----SQ-RAKWKKLFDRAE-RLKRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------ERRPYKET-
--------MEII----------------FKYI--WDFENYIHVPSH--------------
---------------------------------E-------YNIITEMQHRTLKDIFDLQ
-----LE-S----VT

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 929)

AVILGNKGEGKTTFLRKA-----MLDWA--A---------GDLWQ
N--------RFHY-VFFFSLMSLNNIT-------ELSLAQ-LILS-KL-----SES-SET
LEDIVS-DP----RRILFILEGFDY-LKFDLG-L------QT-N-----LCNDWRKK-AP
-TQIVLSSLLQKVMLQESSLLLE-LGNLSVPKIYPLL-Q-----KPR--EITIGGYTEAS
VKYYC----------------C--SF-MHS---------FKKGSEIFNYLQA-IQLLLTL
CKNPYKRWMVCRTLKCQFKRGE-KL-N--IA-FKPDSVLYTSFMVSSFRAKY-AGYPSR-
-----------QNRNKLMTLCTLA---VEGM-WK-SV----FVFKYE-------------
--DLLRNGISES-EQILWMKM----YFLNTRG-----DCFVFYHPALQLYFAALFYFLR-
QDKDK-----------------H--HPIIGSLP-QLLREIYAH-GQNQWLLTGKFV----
----FGIATEKIAAILEPHFGFI---------------P--CEK-MRQ-EIFKCFRSLSQ
GEC----------------------------------GEKL-ISPQSLFDSLVENQE-EQ
FITQVMDM---------------------F-------------------EEMTVDISSAD
VL---SVA--T----TCLL-KSQS-LKK-LHLH----------------IQQR----VFS
-EIYNPED-----------G-------------------D-L-------E-VFKHEKNNA
IKHWRMLC-RVFQ---NLEVLDLDSCKFNVT---------VIFLLY--LSMSPTHRGPLN
AF--K-LQSFSCSY---------LTN-FGC-GLLFHTL----------------LQLPHL
KSLN-LYGT-NLSND-VVENMCCVLKSPSCR----VEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GKCDIS-----------------------------
----------------------------SEACGVIAT-----------------------
--------------------------------SLTKC-KVKH---LS-LVENP-LKN---
-------KGVMLVCEIL----KHPSCVLETL-----------------------------
------------------------------------------------------------
------------------------------MLSYCCFTFIACGHLYEA-LLHNKYLSLLD
L-SSNFLEDTGVN-ILCEALKDP--RCN----L---------------------------
-----------------------RELWL--SGC-----YLTSDCCKAI------------
-------SAVL-SCNQNLKTLKLGSNNIQDTGIKQ-LCEALR-NP-GC-KLQCLG--LD-
--M-CEFTTDSCA--------------------DLALALTTCKTL-TVLSLDWMTLGHNG
LELLCE--------ALNHKGCT--LK--V-------------------------------
---L--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MSPDYREKYREH-
--------VRKK----------------YCSP--EDGNPCLMVQI---------PPNEKY
TKMVVAS----GKEKEHEIL------TRPWRHTQLLF----EQ--MP--ATTIDVLFDTE
ND-----AP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLFGVAGVGKTLMARKI-----MQDWA--T---------RSQSP
E--------RFDS-VFYLSCRQMNLIVGE------VNLAE-LILN-NH-SE--PR-LGEA
INKLLI-NP----GKCLFIIDGFEE-LNCSIKQE------GD-N-----LSISPYEK-KP
-VELILSSLFCKTLFPESCLMIT-TRPNTLESLEDCL-P-----SPR--YVRHLGFSEEG
KKEYF----------------C--KF-FGE---------EELAAQALSYIKR-NEALLAI
SFVPGVCWIICTMMKEQLDRAEKDL-V--PV-SDTLTGVYALYLSHLFKSFCTGS-----
-----------EQLDLMKTLCSLA---ADGL-WE-KK----PFLKEE-------------
--DIRKE---------LALHG----TLFRKDPD-CE-GSYSFFHPSIQEFLAALFYVSE-
DLSRG-----------------T--ETTKENMN-IFLDACH-E-VRGDLTLTVQFV----
----FGLLNKEIMKYLKEQFEWN-----------------ISPK-IKT-DLIEWFQLDT-
QIE----------------------------------FIRPNYGQLERFYSLYEVKEEEE
FVKHALNH---------------------L-------------------TELTLQDLTFT
QM-DQVVL--C----YCIN-NCLN-LET-LS------------------LYRC----LFL
LEECETEVLQRLPNYP--DQPLQKTEK-PSAI--DLLCQTLKDPDGKIKKVELDGC-QFT
DTFWEDLS-VVLSTSLVLVELDLQMTNLKDS---------GVRLLR--EGLIH-P-----
NC--K-LNKLG--L-WGCDLT--HA----CGDDLFTIL----------------SHSHTL
MELK-LGCNSSLGIQ-GVQLLCEGFKHPNCK----LQSL--------GLD---------E
CGLNAAGCQ-----HFIPVLSI----SQTLRKLTLESNKLGDVGVKLLCEGLKHPQCQ-L
ETLSLATCELS---PA-CCG---DLSSVLSI-SQTLRELELEYNKLED-TGLRLLCEG--
LKQ-PQCKLEKL-G----------------------------------------------
------------------------LAGCGIT-----------------------------
----------------------------AA----SCGDLAC-------------------
------------------------------ALAVKW--TLKH---LD-IEYNK-LGD---
-------SGVKMLCEGL----KHPHC----------------------------------
--------------------------RME-TLN---------------------------
-------------------------------LFTCDLTAACTKDLASI-LCCNQTLAQLF
L-GGNMLGDSGLK-QLCEGLKHS--QCK----I---------------------------
-----------------------KKLCL--CDT-----GITAAGCMEL------------
-------SSVL-STSQALEDIDLWQNTLEDSGLRL-LCEGLK-HP-------------D-
----CK---LEVLSMWGCKFTSASCG-------DLQCVLSTNQNL-KKLQLENNKLGDSG
VLLLCE--------GLKHPNCK--LK--S-------------------------------
---IGLDIE-ELSEDTVRE------LK----------YLK-RMKPRLTIDT---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MAESNSTDFD---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

LLWYLENLS--D---KEFQSFKKYLAR------
---------K--ILDFK--------L--PQV-PLIN-LGA-T-KEELANLLPISYEGQHI
WNMLYSI----FL-MMRKEDHCMKI---IGRRN---------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------RNQEACKAL-
--------MRRK----------------ITLR--WENHTFGEFHYKFFCNVA--------
----------------------------------------------SDVFYVLQLAYDST
SC--YSAND----LN

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 930)

VFLMGDRASGKTMTINLA-----VMKWI--N---------GEMWQ
N--------MISY-VVHLTSHEINQMT-------DSSLAE-LIAK-DW-----PD-GQAP
IADILS-DP----KKLLFILEDVDN-LRFELNVN------EH-A-----LCSNSTQK-VP
-IPILLVSLLKRQMAPGCWFLIS-SRPTREENIKMFL-K-----TTD--CYVTLQFSNEK
RELYF----------------H--SF-FND---------RQRASTALMLVHD-DEILTGL
CRVAILCWITCTVLNRQMDKG-HDP-Q--HC-CETPTDLHAHFLADALTSKAGLT-AN--
----------QYHLGLLRRLCLLA---AGGL-FL-ST----LNFSGE-------------
--DLRCVGFTEV-DFSVLQAV----NILLPSST-HK-DRYKFIHLNVQEFCAAIAFLMAV
PNCLI-----------------P----SGSR-G--Y--KEKRE-QYCNFNQVFTFI----
----FGLLNENRRKILETTFGYQ---------------LPMVES-FRR-YSVEYMKHLGR
DQ-------------------------------------QKLTHHGSLFYCLFENQE-EE
FVKKVANT---------------------L-------------------KEVTLYLQSNK
DM---MVS--L----YCLE-YCCH-LRT-FKLS----------------VQR-----IFE
--YKEPLV-------------------------------------------RPTASQMKS
LVYWREIC-SLFCTMDTLWELHLFDSDLNDI---------SERILS--KALEHS------
SC--K-LRTLKLSY---------IST-ASGFEDLLKAL----------------ARNRSL
IHLS-LNCT---------------------------------------------------
------------------------------------------------------------
--------------------------------------------SISL-NMFSLLREI--
LDK-STCQIRHL-S----------------------------------------------
------------------------LMKCDLR-----------------------------
----------------------------ASECGEIAS-----------------------
--------------------------------LLVNGGSLRK---LT-LTNNP-LRN---
-------DGVNILCNAL----LHPNCTLTSL-----------------------------
------------------------------------------------------------
------------------------------ALVFCCLTEQCCSSLGRV-LLLGRTLKQLD
L-CVNHLQNYGVL-HVTFPLIFP--TCQ----L---------------------------
-----------------------EELYL--SGC-----FFTNDICQYI------------
-------AIVIA-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

NETLRSLEIGSNSIEDAGMQL-LCGGLR-HP-DC-MLVNIG--LE-
--E-CMLTGACCA--------------------SLASVLT

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2464)

TNKTL-ERLNILQNQLGDEG
VVKLLE--------SLILPECV--LQ--I-------------------------------
---IGLPLN-DVSAETRRM------VM----------TVK-ERKPNLIFLSETWSVKEGR
EIGVI-------------------------------------------------------
-------------------------------------------------------PASQP
GSV-----------------IPNSNLD---YM--FFKFPRMSTAMRMSSTASRQPL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------LVTLSTGPTCSMLPKNP------------L-------------------FPQ-N
L---SSQPCLKMEGDKSLTFS

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 326)

SYG---LQWCLHELD--K---EEFQTFKELLKK------
---------K--SSEST--------T--CSI-PQFE-IENAN-VECLALLLHEYYGASLA
WATSISI----FE-SMNLPTLSEKAR-DDMKRHS-----PEDLEPTTT--GQGPSKEEVP
G-----NSHVVGQESA--AAAE-------------------------TKEQEISQAME--
QE-SATAA---------ETEEQEISQAMEQEGA---------------------------
-----T---A-------------------------------AETEEQECGGDKWDYKSH-
--------VVTK----------------FAVK--EDVR-RGFEKT---------------
------------------------------------A-------DWPEM-QMLAGAFNSD
Q---WGFRP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 922)

HTVVLHGKSGIGKSALARRI-----VLCWA--Q---------GGLYQ
G--------MFSY-VFFLPVREMQQKK-------ESSVAE-FISR-EW-----PD-AQAP
VTEIMS-RP----ERLLFIIDGFDD-LG-SVLNS------DT-K-----LCKDWAEK-QP
-PFILIQSLLRKVLLPESFLMVT-VRDVGIEKLTSEV-V-----SPR--YLFVRGITAEQ
RIHLL----------------L--ER-GIG---------EHQKTQGLCAIMN-DRKLFDQ
CQVPAVGSLICVALQLQDVVGE-SI-A--PF-GQTLTGLYAAFVFHQLTPRG-VARRCLN
----------LEERVVLKRFCRMA---VEGV-WN-MK----SVFDGD-------------
--DLMVHGLGES-ELRTLFHM----NILLRDSH-CE-EFYTFFHLSLQDFCAALYYVLE-
GLEIE--------------PALC--PLFVEKTK-RSMELQQAG-FHIHLLWMKRFL----
----FGLVSEDVRRPLEVLLGCP---------------V--PL-GVKQ-KLLHWVSLLGQ
QPN----------------------------------AA-TPGDTLDAFRCLFETQD-KE
FVRSALNG---------------------F-------------------QEVWLPINQNL
DL---IAS--S----FCLQ-HGPY-LRK-IRVD----------------VKG-----IFP
-RDELAEA----WP--------------------VV-----------PQ--WMRGK-TLM
EDQWEDFC-SVLSTHPHLRQLDLGSSILTER---------AMKTLC--AKLRH-S-----
TC--K-IQTLM--F-RNAQI---AS---GLQ-HLWRTL----------------IANRNL
RSLN-LGGT-HLKEE-DVRMACEALKHPKCL----LESL--------RLD---------R
C------G----------------------------------------------------
---------LT---HA-CYL---KISQILTT-SPSLKSLSLAGNEVTD-QGVTPLSDA--
LRV-SQCALQKL-T----------------------------------------------
------------------------LEDCGIT-----------------------------
----------------------------ATGCQSLAS-----------------------
--------------------------------ALVSNRSLTH---LC-LSNND-LGN---
-------EGVNLLCRSM----RLPHC----------------------------------
--------------------------SLR-RLM---------------------------
-------------------------------LNRCNLDTAGCGFLALA-LMGNAWLTHLS
L-SMNPVEDNGMK-LLCEVMREP--SCH----L---------------------------
-----------------------QDLEL--VKC-----HLTAACCESL------------
-------SCVI-SRSRHLKSLDLTDNALGDGGVTA-LCEGLK-QK-KS-VLTRLG--LK-
--A-CGLTSDCCE--------------------ALSL-ALSCNRHLTSLNLVQNNFSPEG
MMKLCS--------AFACPTSN--LQ--I-------------------------------
---IGLWKW-QYPVQIKKL------LE----------EVQ-LLKPRIVIDGSWHSFD---
--E---------------------------------------------------------
--------------------------------------------------DDRYWWKN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MEEISGYD---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 321)

LALCLQKLS--Q---ADFMTFKVLLRK------
---------A--PEEFE--------L--NPI-PWTE-IKMAS-RKGLVMLLNKNYPGK-V
WDIALSL----FQ-KVKRKDLFAMTE-ALRRD----------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------KGTPYKET-
--------MKTL----------------FNFI--WNFESGIYVPYH--------------
---------------------------------E-------FEIITEMQYSSLQVVFEPQ
-----SQ-P----VT

PF05729 // ENSGT00900000140813_0_Domain_2 (676, 905)

AVILGNKGEGKTTFLRRA-----MLDWA--S---------GDLWQ
N--------RFQY-VFFFSLMSLNDIT-------ELSLAQ-LLLS-KL-----SES-SES
LEDILS-DP----RRILFILEGFDY-LKFDLE-L------RT-N-----LCNDWRKT-VP
-TQIVLSSLLQKVMLPESSLLLE-LGNLSVPKIYPLL-Q-----KPR--DITLGGYTDEA
IKYYC----------------M--SF-MYS---------YTEGSAIFNYLQT-MQPLLTL
CKNPYKRWMVCSTLKCQRKRGE-NM-N--ID-YKPDSALYASFMVNSFRAEY-ANRPSR-
-----------QNRDQLKPLCTLA---VEGM-WK-LV----FVFKPE-------------
--DLYRNGISES-GQIVWLKM----NFLNTRG-----DHFVFYHPALQLYFAALFYFLR-
QDEDR-----------------P--HPVIGSLS-QLLREIYAH-DQNQWLLTGIFV----
----FGIATEKVAAILEPHFGSI---------------P--SEE-MRQ-EILKCFRNLSR
GEC----------------------------------GEKL-RSPQSLFASLVDNQE-EG
FIRQVMDL---------------------F-------------------EEMTIDISSAD
AL---SVA--T----TCLL-KSQR-LKN-LHLH----------------IQHR----VFS
-EKYKPED-----------A-------------------T-R-------NNGMLSHCSNA
IKHWRMLC-RVFQ---NLEVLDLDSCNFNET---------AISLLY--LSMYPSHRGALN
AF--K-LQSFSCSF---------VTN-FGH-GVLFHTL----------------LQLPHL
KSLN-LYGT-NLSND-VVENMCCVLKCSTCR----VEEL--------LL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GKCNLS-----------------------------
----------------------------SEACGIIAT-----------------------
--------------------------------SLIFC-KVKH---LS-LVENP-LKN---
-------KGVMLLCETL----KRPSCDLETL-----------------------------
------------------------------------------------------------
------------------------------MLSYCALTFIACGHLYEA-LLHNKYLSLLD
L-SSNFLGDTGVN-ILCKALKDP--MCP----L---------------------------
-----------------------QELWL--SGC-----YLTSDCCEEI------------
-------SAVL-T

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

HNQKLKTLKLGNNNIQDTGVRQ-LCEALS-NP-EC-KLQCLG--LD-
--M-CEFTTGSCA--------------------DLALALTTCKTL-TMLNLDRMTFDRDG
LKLLCE--------ALNHKDCN--LK--V-------------------------------
---LGLDKS-AFCEESQKI------LQ----------EVE-KKN-TLDILHYPWIKE---
--ESK-----KR------------------------------------------------
--------------------------------------------------GVRLVWNSEN
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASFISDFG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LIWYLRELN--K---KEFMKFKDFLIQ------
---------E--ILELK--------L--KQV-SSTK-VKKAS-REDLANLLLKCG-ENQA
WDMTFRI----LQ-KINRKDLTERAT-GAI------------VG--------------NP
N---------------------------------------------------LYRD----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKK----------------LTHD--CPKKFNVRIQDF--------------
---------------------------------I-------KETFIQNDYDAFENLLISK
GT--ERK-P----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

MVFLKGMAGVGKTLMLKNL-----MLAWS--K---------GLVFQ
N--------KFSY-AFYFCCQDVKQLK-------TASLAE-LISR-EW-----PSP-SAP
IEEILS-QP----EKLLFIIDSLEG-MEWDLTKQ------ES-E-----LCDDCMEK-QP
-VSTLLSSLLRRKMLPESSLLLS-TTPETFEKMEDRI-Q-----CTD--VKTATAFDERS
MKIYF----------------H--RL-FQD---------RKRAQEAFSLVRE-NKQLFTI
CQVPLLCWMVATCLKEEIEKGG-DP-V--SL-CRRTTSLYTTHIFSLFIPQS-AQYPSK-
-----------KSQDQLQGLCSLA---AEGM-WT-DT----FVFGKE-------------
--ALRRNGIFDS-DIPTLLDI----GMLGKIRE-FE-NSYIFLHPSVQEVCAAIFYMLK-
RHVEH-----------------P--SQDVKNIE-TVLFMFLKK-VKTQWIFLGCFI----
----FGLLQKSEQEKLGVFFGHR---------------L--SKN-IHH-KLYQCLETLSG
NAE-----------------------------------LQEQIDGMRLFSCLFEMED-EA
FLVKAMNC---------------------M-------------------QQINFVAKNYS
DF---IVA--A----YCLK-HCST-LKK-LSFS----------------TEN-----VLN
--EG--DQ-----------S-----------------------------------YMEEL
LICWNNMC-SVFVRSKDIQELRIKDTNFNEP---------AIRVLY--ESLKYP------
SF--T-LNKLVANN---------VS--FGDNHVLFEL-----------------IQNSSL
QYLD-LSCS-FLSHN-EVKLLCDILNQAECN----IEKL--------MI-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------AHCKLS-----------------------------
----------------------------PDDCKIFGS-----------------------
--------------------------------ILMSSKSLKV---LN-LASNN-LN----
-------QGISSLCKAL----CHPHCTLEYL-----------------------------
------------------------------------------------------------
------------------------------VLSNCSLSEQCWDYLSEV-LR

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2233)

QNKTLSHLD
I-SSNDLKDEGLK-ILCRSLILP--YCV----L---------------------------
-----------------------ESLCL--SCC-----GITERGCQDL------------
-------AEVL-K

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

NNQNLKYLHVSYNKLKDTGVML-LCDAIK-HP-NC-HLKDLQ--LE-
--A-CEITDASNE--------------------ELCYAFMQCETL-QTLNLMGNAFEVSR
MVFFPR--------F---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MLRT----AGRDGLCR

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LSAYLEELE--A---VELKKFKLYLGT------
---------A--TELGE--------D---KI-PWGR-MEMAG-PLEMAQLLITHFGTEDA
WRLALST----FE-RMNRKDLW

ENSGT00900000140813_0_Linker_0_1 (323, 536)

ERGQ-REDLVRDT----P--PG--------GPSSL---
------------------------------------------------------GN----
------------------------------------------------------------
---QS-TCLP-------------------------------GVSPVTPRKDPQEA

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 658)

YRDY-
--------VRRK----------------FRLM--EDRNARLGECV---------NLSHRY
TRLLLVKEHSNPMQAQQQLL------DIGRGHTRTVG--------HQASPIKIETLFEPD
EE--RPEPP----RAVVMQGVAGIGKSMLAHKV-----MLDWA--D---------GKLFQ
G--------RFDY-LFYINCREMNQSDT------ECSMQD-LISS-CW-----PE-PSAP
LQELVR-VP----ERLLFIIDGFDE-LKPSFHDP------QG-P-----WCLCWAEK-RP
-TELLLNSLIRKKLLPELSLLVT-TRPTALEKLHCLL-E-----HPR--HVEILGFSEAE
RKEYF----------------H--KY-FHD---------TEQAGQVFNYVRD-NEPLFTM
CFVPLVCWVVCTCLQQQLEGGG-LL-K--QT-SRTTTAVYMLYLLSLMQPKLRT-ARL--
-----------QPPPNQRGLCSLA---ADGL-WN-QK----ILFEEQ-------------
--DLRKHGLDGA-DVSAFLNM----NIFQKDIN-CE-RYYSFIHLSFQEFFAAMYYILD-
D--GE--------------R--G--AGPDQDVI-RLLTEYGFS-ERSFLALTIRFL----
----FGLLNEETRSYLENSLCWK---------------V--SPH-IKR-ELLQWIRSKAQ
SD-----------------------------------GSTLQQGSLEFFSCLYEIQE-EE
FIQQALSH---------------------F-------------------QVIVVSNIA-S
KM-EHMVC--S----FCVK-NCRS-AQV-LHLY----------------GA------TYS
-ADGEDRA--R-CS---------------------------------------AGA---H
TL------------------------L-------------------------V-------
QL--R--------PERTVLLD-------AYSEHLAAAL----------------C

PF13516 // ENSGT00900000140813_0_Domain_6 (1616, 1642)

TNPNL
VELS-LYRN-ALGSR-GVKLLCQGLRHPSCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------RIS---SS-ACE---DLSAALIA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

NKNLTRMDLSGNGVGF-PGMMLLCEG--
LRH-PQCRLQMIQ-----------------------------------------------
------------------------L-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------KICHLTAAACEELAST-LSV

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NHSLRELD
L-SLNELGDPGVL-LLCESLRHP--TCK----L---------------------------
-----------------------QTL-----IC-----RLGSAACEGL------------
-------SAVL-QV

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2373)

NHHLRELDLSFNDLGDWGLWL-LAEGLQ-HP-TC-RLQKLW--LD-
--S-CGLTAKACK--------------------NLYFTLGI

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NQTL-TELYLTNNALGDTG
VRLLCK--------RLNHPGCK--LR--V-------------------------------
---L--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------RWCGAPRGSSGCSGPRRQ
LSEEPTARARSLEPR--AAAAREL---LLAALQYLS--Q---DQVKRFLLKLRD------
------------AP------------------------------------LTHFYGPEPA
LDVTRRT----LK-RADVHDVAARLK-AQRLQPP--------S---------CRA-----
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------PT-SASLPKEFQKKYRER-
--------VLQQ----------------HAEV--KE----------------------RF
TKLLIAPESAAPGEKEVALGPAE-------KPKP--------GRAWRSDTRTFSRLLSSD
A---EGPRP----P

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 890)

TVLLQGPAGIGKTMAAKKI-----LYDWA--A---------EKLYR
G--------QVDF-AFFLQCRELLEWPG------ARSLAD-LILD-QC-----PD-RGAP
LSRMLA-QP----QRLLFILDGA---------------------------------A-AS
-GARVLGGLLRKALLPSARLLVT-TRATASGKLHFGL-C-----APK--CAAFPPETRRN
T----------------------------------------STSSSGRSAGR-TETLFAL
CFVPAVCWIVCTVLRRQLELGQ-DL-S--RT-SKTTTSVYLVFLASALSSV-GAEGP---
-----------GVRAKLPKLRRLA---REGVLGH--K----AQFSEG-------------
--DLERLELRGSVVQH-FLIKKELPSVLET-----E-VIYQFINQSFQEFFAALSYLLE-
DVGAP-------------------G-VSTGGLE-TLLCLGSEG--RSHLMLTTRFF----
----FGLLNMERVQDVERHFGC-----------------VVPAH-VKQ-DALRWVQGQSH
LR--VASEGTDGTKGLKDTEEPEEK-----------EEEEEPNFPLELLYCLYETQD-EA
FMYQALSS---------------------L-------------------PELMLERVCFH
RM-DLDVL--S----YCMR-CCPA-GQVL-WLV------------------SC----SLM
------A-----------------------------------------GQEKKR---KRS
----------------------------------------LVKR----------------
------LK-G---------------------------------------------SQAAM
KQ---LRVS-------PLHPLFG-------------------------MS---------R
C-----------------------------------------------------------
--------KLP---DR-IYR---DLSMALRA-APALTELGLLHCRLR-EAGLRVLNEG--
-LAWPQCRVQTL------------------------------------------------
----------------------------RVL-----------------------------
---------------LLKP---------LEAFQCL-------------------------
------------------------------VALPWQSPTLTT---PD-LSGC-YLPDPMV
--TY--------LCAAR----QHPGCSLQTLR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
--------------------------------------------MKVAEGLEL-GAVDLL
QDPLLNLVTLSTGPTCSMLPKNP------------L-------------------FPQ-N
L---SSQPCLKMEGDKSLTFSSYG--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LQWCLHELD--K---EEFQTFKELLKK------
---------K--SSEST--------T--CSL-PQFE-IENAN-VECLALLLHEYYGASLA
WATSISI----FE-NMNLPTLSEKAR-DDMKRHS-----PEDLEPTTT--GQGPSKEEVP
G-----ISEAMQQETA--TAAE-------------------------TKEQEISQDME--
QE-GATAA---------ETEEQEISQAVEQEDA---------------------------
-----T---A-------------------------------AGTEEQECGGDEWDYKSH-
--------VVTK----------------FAVK--EDVR-RGFEKT---------------
------------------------------------A-------DRPEM-QMLAGAFNSD
E---WGFRP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 925)

HTVVLHGKSGIGKSALARRI-----VLCWA--Q---------GGLYQ
G--------MFSY-VFFLPVREMQQKK-------ESSVAE-FISR-EW-----PD-SQAP
VTEIMS-RP----ERLLFIIDGFDD-LG-SVLNS------DT-K-----LCKDWAEK-QP
-PFVLIQSLLRKVLLPESFLMVT-VRDVGIEKLKSEV-V-----SPR--YLFVRGISAEQ
RIHLL----------------L--ER-GIG---------EHQKTQGLRAVMN-NRKLYDQ
CQVPAVGSLICVALQLQDVVGE-SI-A--PF-GQTLTGLYAAFVFHQLTPRG-VGRRCLN
----------LEERVVLKRFCRMA---VEGV-WN-MK----SVFDGD-------------
--DLMVHGLGES-ELRTLFHM----NILLRDSH-CE-EFYTFFHLSLQDFCAALYYVLE-
GLDIE--------------PALC--PLFVEKTK-RSMELQQAG-FHIHLLWMKLFL----
----FGLVSEDVRRPLEVLLGCP---------------V--PL-GVKQ-KLLHWVSLLGQ
QPN----------------------------------AA-APGDTLDAFRCLFETQD-KE
FVRLALNG---------------------F-------------------QEVWLPINQNL
DL---IAS--S----FCLQ-HCPY-LRK-IRVD----------------VKG-----IFP
-RDELAEA----WP--------------------VV-----------PQ--WMRGK-TLM
EEQWEDFC-SVLSTHPHLRQLDLGSSILTER---------AMKTLC--AKLRH-S-----
TC--K-IQTLM--F-RNAQI---AP---GLQ-HLWRTL----------------IANRNL
RSLN-LGGT-HLKEE-DVRMACEALKHPKCL----LESL--------RLD---------R
C------G----------------------------------------------------
---------LT---HT-CYL---KISQILTT-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SPSLKSLSLAGNEVAD-QGVTPLSDA--
LRV-SQCALQKL-T----------------------------------------------
------------------------LEDCGIT-----------------------------
----------------------------ATGCQSLAS-----------------------
--------------------------------ALV

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

NNRSLTH---LC-LSNND-LGN---
-------EGVNLLCRSM----RLPHC----------------------------------
--------------------------SLR-RLM---------------------------
-------------------------------LNRCNLDTAGCGFLALA-LMG

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2237)

NTWLTHLS
L-SMNPLEDNGMK-LLCEVMREP--SCH----L---------------------------
-----------------------QDLEL--VKC-----HLTAACCESL------------
-------SCVI-SR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

SRHLKSLDLTDNALGDGGVTA-LCEGLK-QK-KS-VLTRLG--LK-
--A-CGLTSDCCE--------------------ALSL-ALSC

PF13516 // ENSGT00900000140813_0_Domain_17 (2443, 2465)

NQHLASLNLVQNNFSPKG
MVKLCS--------ALACPTSN--LQ--I-------------------------------
---IGLWKW-QYPVQIKKL------LE----------EVQ-LLKPRIVIDGSWHSFD---
--E---------------------------------------------------------
--------------------------------------------------DDRYWWKN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MVSST----QVNFN--

PF02758 // ENSGT00900000140813_0_Domain_0 (207, 323)

-LQALLEQLS--Q---DELSKFKSLLRT------
---------V--SLGNE--------V--QKI-PQKE-VDEAD-GKQLAEILISHCHSYWT
ELATIQV----FE-KMHRVDLSERAK-DELREAAL-KSFN----KNK------PLSLG--
------ITRKERQP---------------------------------LDVEEMLERFK-A
GTLECT---------------------------------ET--EEDVTV-----------
-------LTE-------------------------------VFKVKGEKSDNENRYRLI-
--------LKTK----------------FREM--WQ--SWPGDRKEVRV-----------
---------------------------------------------VAERYRMLIPFSNPR
ML--PGPFS----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

HTVVLHSPAGLGKTTLANKL-----MLDWT--E---------DNLIQ
---------KFKY-AFYLSCRELNRLG-------PCSFAE-MVFR-DW-----PE-WQDD
IPHILA-QA----QKILFVIDGFDE-LGAPPG------ALIQ-D-----LCGDWEQQ-KP
-VPVLLGSLLKRKMLPKAALLVT-TRPSALRDLRFLA-E-----QPI--YIRVEGFLEED
RRAYF----------------L--RH-FGD---------EDQAMRAFELMRS-NAALFQL
GSAPAVCWIVCTTLKLQMEKGE-DP-A--PT-CLTSTGLFLRFLCSQFPQ-------GAQ
------------LQGALRALSHLA---AQGL-WA-QM----SVLHGE-------------
--DLERVGVQES-DLRPFLDR----DILRQDRV-SK-GCYSFIHLSFQQFLTALFYALE-
KEEEE-------------DRDGH--AWDIGDVQ-KMLTREERL-RNPDLIQAGRFF----
----FGLANEKRAKELEATFGCQ---------------M--SPE-IKQ-ELLRCDVSRKN
G------------------------------------H-SMVADLKELLCCLYESQE-DE
LVKEVMAQ---------------------F-------------------KEITLHLN-AV
DI---APS--S----FCVK-HCRN-LQK-MSLQ----------------VIK-----ETL
-PENVAAS----ES--------------------NAEAER------------SQDD-QDM
LPFWTDLC-SIFGSNKDLMGLEINNSFLSAS---------LVKILC--EQIAS-D-----
NC--H-LQRVV--F-KNISPA--DA----HR-NLCLAL----------------RGHKTV
THLT-LQGN-DQKD--VLPALCEVLTHPECN----LRYL--------GLV---------S
C------S----------------------------------------------------
---------AT---TQ-QWA---DLSLALEA-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1795)

NQSLMCVNLSDNELLD-EGAKLLYTT--
LRH-PKCFLQRL-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EANCKDLAA-----------------------
--------------------------------VLVVSRELTH---LC-LAKNS-LKD---
-------TGVKFLCEGL----SYPEC----------------------------------
--------------------------KLQ-ALV---------------------------
-------------------------------LWNCDITSDGCCSLAKL-LQEK

PF13516 // ENSGT00900000140813_0_Domain_13 (2214, 2237)

SSLSCLD
L-GLNHIGVTGVK-VLCEALSKP--LCN----L---------------------------
-----------------------RCLWL--WGC-----SIPPFSCEDL------------
-------CSAL-SC

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2377)

NQSLITLDLGQNPLGSSGVKM-LFKTLT-RP-NS-TLQTLR--LK-
--I-DDFNDELHK--------------------LLEEIEENNPQLIIDTEKH----DPWK
---------------KRPSSHD--FM----------------------------------
----I-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MKTEDEE-MED------------
------------------------------------------------------------
----------------------QL------------------------------------
-------SKE-------------------------------EIVSEDKEF----DYRTI-
--------IKEN----------------FFII--WDKTSLLGESATLNCVTT--------
----------------------------------------------HKDQKLLEHIFDVN
IQ--TSKSP----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

TVVLYGAAGIGKTTLLKKA-----VLEWA--D---------GNLYQ
---------QFTH-VFYLSGREISQEK-------EKNFAQ-LISK-HW-----PS-SEGP
IEQILC-KP----SSLLFILDSFDE-LDFSFEEP------EF-A-----LCRDWTQK-HP
-VSFLISSLLRKVMLPESYLLVT-TRTTAWKRLVPLL-Q-----KPH--RVKLPGLSRSS
RIDYI----------------H--HL-LKD---------KTWAMNAVCSIRM-NAKLFNM
CHVCHVCQMICTFLKEQVEKGG-NV-E--MT-CQTSTALFTYYICSLFPRI-AGSSVTLP
------------NETLLRSLCQAA---VEGI-WT-MK----HVLYQQ-------------
--NLRKHELTRE-DLSLFLEA----NVLQQDTE-CE-NCYTFTHLQVQEYFAALFYLLR-
ENPEE--------------KDHP--LEPFENVH-LLLESNHFH--DPHLEQMKCFL----
----FGLLNKDRVQQLEETFNLT---------------I--SRA-VRE-ELLVCLEALEK
DD-----------------------------------SPLSQLRIQDLLHCIYETQD-EE
FITQALTY---------------------F-------------------QKIMVKVDEES
KL---LIY--S----YCLK-HCHS-LQT-VRLT----------------ARA-----DLR
-----NML------DP-----TA--E------------------------ICLEDAAVRI
IHYWQDLF-SVLHTNESLLEMDLYESRLDES---------LMKILN--EEFSHP------
KC--N-LQKVMFRA---------VCF-LNSCYD-FSFL----------------AF

PF13516 // ENSGT00900000140813_0_Domain_6 (1617, 1642)

NNTV
THLD-LKDT-DLGDN-GVKTLCEALKYQGCK----LRVL--------RLE---------S
CD----------------------------------------------------------
---------LN---VT-HCQ---NLSKALQS

PF13516 // ENSGT00900000140813_0_Domain_8 (1772, 1796)

-NRSLVFLNLSTNSLSN-DGVKSLCEV--
LEN-PNCPLERL-A----------------------------------------------
------------------------LASCGLT-----------------------------
----------------------------KVGCEVLSS-----------------------
--------------------------------ALTKTK

PF13516 // ENSGT00900000140813_0_Domain_11 (2019, 2054)

RLTH---LC-LAHNV-LED---
-------EGIELLSYTL----RHPRC----------------------------------
--------------------------TLQ-SL----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------VL--MGC-----VLTSEACGDL------------
-------ASVL-VNNSNLWNLDLGNNILDDAGLNI-LCEALR-NP-NC-QIRRLG--LE-
--N-CGLTPGCCQ--------------------DLLDLLSNNQSV-IQMNLMKNSLDYEA
IRNLCK--------VLRSPTCK--ME--F-------------------------------
---LALDKKDLFKKKIKKF------LV----------DVR-INNPHLVIRPQCPN-----
--T---------------------------------------------------------
--------------------------------------------------ESGCWWQYF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------M-SDVNPPSD------------T-PIPFSSS-------------S-T
H---SSCNPPWTFSCYPGSPCENG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 322)

VMLYMRYVS--N---KELQSFKQFLLN------
---------E--L-RAG--------T--TPI-TWDQ-VKRAS-WAEVVHLLIERFPGRRA
WDVTSKI----FA-VMNCDKMCALVH-REINAILP-TLEPEDLNVG------E-------
------------------------------------------------------------
------------------------------------------------------------
-------TEV-------------------------------NLEEGES--GKIQQYKLN-
--------VIVK----------------CFPT--WDFMTWPGNQRDFFYQDV--------
----------------------------------------------HRHMEYLPCLLLPK
RP--RGRQP----K

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 928)

TVVIQGVPGIGKTTLAKTV-----MLEWA--S---------NRFYA
H--------KPWC-AFYFHCQEMNQTT-------EHSFSE-LIEH-KW-----PG-SQDL
VAKIMS-KP----DQLLLLLDGFEE-LTSTLI------NRPE-D-----LSEDWRQK-LP
-GSVLLSSLLSKRMLPEATLLIM-IRCTSWPTCKPLL-K-----RPS--LVTLPGFNTTE
KIKYF----------------Q--MY-FGY---------GE-TDRVLSFAME-NTILFSM
CQVPVVCWMVCSGLKQQMERGN-NL-T--QA-CPNATSVFVRYISSLFPTRA-ENFSRKI
------------HQAQLEGLCHLA---ADGM-WH-RQ----WVFGKE-------------
--DLEEAKLDQM-GVAAFLGM----SVLRRIAG-EE-DRYTFTLLIFQEFFAALFYVLC-
FPQRL--------------QNFH--VLSHMNIQ-RLIASPR-G-SKSYLSHMGLFL----
----FGFLNGTCALAVEQSFRCK---------------V--SFN-NKR-KLLKVIPLLQK
CE-----------------------------------PPSPCSGVPQLFYCLHEIRE-EA
FVSQALNG---------------------Y-------------------HKAVLKIGNSK
DV---QVS--A----FCLK-RCEH-LQE-VELT----------------VTL-----NLK
-NVWKLSS----G-------------------------------SRPGS--EAPES-KEL
HCWWQDLC-SVFATNDKLEVLTLTNSALGPP---------FLKALA--AALKH-P-----
QC--K-LQKLL--L-RRVNST--ML---N-Q-DLIGVL----------------MGNEHL
RYLE-IQHV-EVESN-VVKLLCKALRSPRCR----LQCL--------RLE---------D
C------L----------------------------------------------------
---------AT---PR-IWT---DLGSNLQV-NRHLKTLILTKNSLEN-CGACY------
--L-SVAQLERL-S----------------------------------------------
------------------------IENCNLT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------QLSCESLASC-LRK

PF13516 // ENSGT00900000140813_0_Domain_13 (2213, 2236)

SKMLTHLS
L-AENALKDEGVK-HIWNALSHL--RCP----L---------------------------
-----------------------QRLVL--RKC-----DLTFNCCQDM------------
-------ISAL-C

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

KNKTLKSLDLSFNSLKDDGVIL-LCEALK-NP-DC-TLQILE--LE-
--N-CLFTSICCQ--------------------AIASMLC

PF13516 // ENSGT00900000140813_0_Domain_17 (2441, 2465)

KNQHL-RHLDLSKNVIEVDG
ILTLCE--------AFSSQKKR--EE--V-------------------------------
---I------FFP-LPPSG------CN----------HSS-FSGA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MPRT----VVKD

PF02758 // ENSGT00900000140813_0_Domain_0 (204, 328)

GLCRLSVYLEELE--A---VELKKFKLHLGT------
---------A---TDMG--------E--DGI-PWGR-METAG-PLEMAQLLVAHYGIGEA
WVLALSI----FD-RINRKDLWERGQ-REDLVMDT----S--PG--------GLSSL---
------------------------------------------------------GS----
------------------------------------------------------------
---QS-ACSL-------------------------------KIFTGTPRKDPRETYRDY-
--------VRRK----------------FRLM--EDRNARLGECV---------NLSHRY
TRLLLVKEHSNPMWAQQKLL------DTGWGHARTIG--------HQTSLIQMETLFEPD
EE--RPEPP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RTVVLQGAAGMGKSMLAHKV-----MLDWA--D---------GRLFR
D--------RFDY-VFYIHCREMNQSAS------DQSVQD-LLSS-CW-----PE-PSAP
LWELVQ-VP----ERLLFIIDGFDE-LRPSFHDS------QG-P-----CCLCWEEK-QP
-TELLLSSLIQKKLLPELSLLIT-TRPAALEKLHRLL-E-----HPR--HVEVLGFSEAE
RKEYF----------------Y--KY-FHN---------TEQAGQVFNFVRD-NEPLFTL
CFVPLVCWVVCTCLKQQLEGGG-LL-R--QT-SRTTTAVYMLYLLSLMQPKPGS-PTL--
-----------QPPPNQRGLCSLA---ADGL-WN-QK----ILFEEQ-------------
--DLRKHGLDGV-DVSSFLNM----NIFQKDIN-CE-KFYSFIHLSFQEFFAAMYYIMD-
G--GE--------------S--G--ASPHQNLR-RLLAEYAFS-ERSFLALTVRFL----
----FGLLNEETRSYLEKCLCWK---------------V--SPN-IKV-ELLQYIRSKAQ
SE-----------------------------------GSTLQRGSLEFLSCLYELQE-KE
FIQQALGH---------------------F-------------------QVVVVSSIT-T
KM-EHMVS--S----FCMK-NCRS-ILV-LHLY----------------GA------AYS
-ADEEDGA--R-WT---------------------------------------SGP---R
M-------------------------PL------------------------T-------
PS--R--------PERNILPD-------AYSEQLAAAL----------------STNPNL
MELA-LYRN-ALGNR-GVKLLCQGLQHPNCK----LQNL--------RLK---------R
C-----------------------------------------------------------
--------LVS---SS-ACQ---DLTAALMT-NKNLMRMDLSSNDLGL-PGLKLLCEG--
LQH-PKCRLQMIQ-----------------------------------------------
------------------------LRKCHLE-----------------------------
----------------------------ARACQEMAS-----------------------
--------------------------------VLSTSR

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2052)

HLVE---LD-LTGNA-LED---
-------LGLKLLCQGL----RNPVC----------------------------------
--------------------------RLQ-ILW---------------------------
-------------------------------LKICHLTAASCEDLAST-LSVNQSLMELD
L-SLNDLGDPGVL-LLCEGLRHP--QCK----L---------------------------
-----------------------QTLRL--GIC-----RLSSAACEGL------------
-------STVL-QLNR

PF00560 // ENSGT00900000140813_0_Domain_15 (2357, 2385)

HLRELDLSFNDLGDRGMWL-LCEGLR-HP-TC-RLQKLW--LD-
--S-CGLTAKASE--------------------DLSSILGVNQTL-IELYLTNNSLGNTG
VRLLCK--------RLSHPGCK--LR--V-------------------------------
---LWLFGM-DLNKMTHRR------LA----------ALR-VTKPYLDIGC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MKMA----STRCK---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LARYLEDLE--D---VDFKKFKMHLED------
---------Y--PPQKG--------C--IPL-PRGQ-TEKAD-HVDLATLMIDFNGEEKA
WAMAVWI----FA-AINRRDLY

ENSGT00900000140813_0_Linker_0_1 (323, 536)

EKAK-RDEPKWD--NAC--AS---------NHTVI---
--------CQ-----------------------------------QDSI-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LGYLSRISICKKKKDYGKK

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 658)

YRRH-
--------VRSR----------------FQCI--EDRNARLGESV---------SLNKRY
TPLRLIKEHRSQQEREQELL------TIGRT--KAGD------SP--VSPIKMESLFE--
PDAEHAEPV----HTVVFQGAAGIGKTILARKI-----MLDWA--S---------GTLYQ
D--------RFDY-LFYIHCRELSLVT-------QRSLGD-LIMS-CC-----PD-PNPP
IHRIVR-KP----SRILFLMDGFDE-LQGAFDEH------IG-P-----LCTDWRKA-ER
-GDILLSSLIRKKLLPEAFLLIT-TRPVALEKLQHLL-D-----HPR--HVEILGFSETK
RKEYF----------------F--KY-FSD---------EAQAREAFSLIQE-NEVLFTM
CFIPLVCWIVCTGLKQQMESGK-SL-AQ--T-SKTTTAVYIFFLSSLLQPRGGSQEHT--
------------LSAHLWGLCSLA---ADGI-WN-QK----ILFEES-------------
--DLRNHGLQKA-EVSAFLRM----NLFQKEVD-CE-KLYSFIHMTFQEFFAAMYYLLE-
EEKE--------GGTQNVPGSCL--TLPSRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTSYLEKKLSCK---------------V--SQQ-IRL-ELLKWIEVKAK
AK-----------------------------------KLQIQPSQLELFYCLYEMQE-ED
FVQRAMDH---------------------F-------------------PKIEINLSTRM
---DHVVS--S----FCIE-NCHR-VES-LSLG----------------FLHN-----MP
KEEEE--------E------------------------------------E---------
---------------KEGRHLDVAQCVPPGS-----------------------------
------------------------------------------------------------
--------------------------LTACS----L-----------GLV---------N
S-----------------------------------------------------------
--------HFT---SG-FCR---GLFSVLST

PF13516 // ENSGT00900000140813_0_Domain_8 (1772, 1796)

-NQSLTELDLSDNSLGD-PGMRVLCET--
LQH-PGCNIRRL-W----------------------------------------------
------------------------LGRCGLS-----------------------------
----------------------------HECCLDLSL-----------------------
--------------------------------VLSS

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2054)

SQKLVE---LD-LSDNA-LGD---
-------FGIRLLCVGL----KHLLCNLKKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSACCQDVASV-LS

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2233)

TNHSLTRLY
M-GENTLGDAGVE-ILCEKAKNP--QCH----L---------------------------
-----------------------QKLGL--VNS-----GLTSACCSAL------------
-------SSVL-STNG

PF13516 // ENSGT00900000140813_0_Domain_15 (2357, 2378)

NLTHLYLRGNTLGDKGIKL-LCEGLL-HP-DC-KLQVLE--LD-
--S-CSLTSHCCW--------------------DLSTLLTS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SRSL-RKLSLGNNDLGDLG
VMMFCE--------VLRQQSCL--LQ--N-------------------------------
---LGLCEM-FFNYETKRA------LE----------TLQ-EEKPELTIVFEPSW-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MACI----PPEFS---LE

PF02758 // ENSGT00900000140813_0_Domain_0 (210, 322)

TLLEQLS--E---DELRRFKSLLKN------
---------L--PLQGK--------L--RMT-PWSE-LEEAN-GKKLAEILIDKSPKYWI
RSVTVNI----LE-KMNLTQLSRRAK-AQIPEGVP-EQ------GI--DA---PKLGD--
------TE------------------------------------------------ENL-
------------------------------------------------------------
---------------------------------------------DVEKPGKMGEHRNT-
---------VEK----------------PRLV--WNNKFWQGDGDYFLDDVT--------
-----------------------------------------------RRSQKFIPFLHPK
TP--TQPIP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVVLHGPAGVGKTTLAKKL-----MLDWT--E---------TSPNQ
---------TSRY-AFYLSCGELSRMG-------TCSFAE-LISK-DQ-----PT-GQED
ISKVLA-QA----QKILFIIDGFEE-LKVPEG------TLIR-D-----ICGDWEQR-KP
-VPVLLGSLLKRKMSPKAMLLVT-TRSEAMRELRLLV-E-----QPL--LLEIEGFLEQD
RKAYF----------------L--RH-FED---------EDGALRALDLVKS-NAALFRM
SAAPAVCRIICTCLKLQMESKQ-DP-A--PS-CLTTTSLFLRFLCGQFMPA-PGGSPSHH
------------LRGPLRTLCLLA---AQGT-WT-QT----WVFDAE-------------
--DLGSLGVQEA-DLRPFLDK----GVLQQGRD-CE-GCYSFVHLSIQQLLAATFYILE-
REEEDD--DD--------DWESH--TRDIGDVQ-KLFSKEERL-KNPNLIQVGYFL----
----FGLSNEKRAQELEMTFGCR---------------V--SLK-IRE-ELLKYKANLDE
NK------------------------------------PFSDTDTKEFLYCLYESQD-EG
LVKDAMAR---------------------F-------------------QEVSVRVTDPF
EM---MCS--F----FCLK-HCQN-LQK-ISLQ----------------VAEG----VFL
-END-PAS----EP--------------------QSQLESKCSCL--FFPSRVGCD-RHS
LRLWRDSS-VG-QLKQDL-----SSLDMMTP---------LVRILC--DHITL-S-----
PV--T-CRKVV--SKKNVTPD--SA----YR-DFCLAL----------------IGKKTL
TRLT-LEGH-VQCDEMLLTMLCEILRHKQCS----LQHL--------RLG---------F
L------S----------------------------------------------------
---------VT---TQ-QWA---DLSSALQI-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1795)

NQSLTCLDLSANELLD-EGVKVLHTT--
FKD-PKCFLQRL-S----------------------------------------------
------------------------LEDCHLT-----------------------------
----------------------------EACCKTLAS-----------------------
--------------------------------VLVV

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2054)

NQQLKY---LC-LAKND-LGN---
-------TGVKLLCKGL----GYPDC----------------------------------
--------------------------KLE-TLV---------------------------
-------------------------------LQQCNINKRGCRHLSKL-LQEHSSLRNLD
L-GLNPIA-AGLW-FLCEALKNP--NCN----L---------------------------
-----------------------KFLGL--WCC-----SIPPFSCQDL------------
-------ASAL-I

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2377)

SNQKLETLDLSQNNLGNSGVTV-LLEALK-QK-NG-PLKTLR--LK-
--A-NDYDWKIQK--------------------LLEEIKEVNPRLAIEYNGA------RT
---------------TRLSCC---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MGPDDART-QE------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------EQDGQETVQGDGTEYRIQ-
--------IKEK----------------FCIM--WDKKSLFGEPEDFHLGVA--------
----------------------------------------------QEHQELLEHLFDVD
VK--TGEQP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

QTVVLQGAAGVGKTTLVRKA-----IVDWA--Q---------GNLYQ
Q--------RFSY-VFYFNAREINQLR-------EQSFVQ-MISK-DW-----PS-REGP
IERIMS-EP----SSLLFIIDSFDE-LNFAFEEP------EF-V-----LCEDWTQV-HP
-VSFLMSSLLRKVMLPESSLLVT-TRPTACKKLKPLL-K----N-QR--SVELLGMSESA
RKEYI----------------Y--QF-FED---------KKRAFQVFNSLRS-NEKLFSM
CKVPLVCCAICTYLDQQMEMGG-DV-S--LT-CKTTTTLFTCYISSFFAPV-DGSCTSLP
------------NQSQLRSLCHLA---ARGV-WT-LT----SVFYRE-------------
--DLRKHGLTKS-DVSIFLDR----NILQKDTE-YE-NCYVFTHLHVQEFLAAMFYVLK-
DNWET--------------RDRS--LQSFEDVK-LLLEANSGQ--DPHLTQMKCFL----
----FGLLNEDLVKQLETTLNCT---------------M--SLE-IKG-KILQWLEILGK
SE-----------------------------------HFPTQLEFLELFLCLYETQD-EA
FISQAMKP---------------------F-------------------QKAVIDVCEKV
HL---LVS--S----FCLK-HCQY-LRA-VKLS----------------VTV-----SCE
-----TML----NSSR-----PA--A------------------------LWQR-DDGHF
THCWQDLC-SVLHTNEHLRELELCHSNLGEL---------AMKTFY--QELRHP------
NC--K-LQKLLLRF---------LSF-PGGCQDIANSL----------------IDNQNL
MHLD-LKGS-DIGDN-GVKSLCEALKHPECK----LQNL--------SLE---------S
CN----------------------------------------------------------
---------LT---TV-CCL---NISKALLR-SQSLRFLNLSTNHLLD-DGIKLLCEA--
LGH-PKCHLERL-S----------------------------------------------
------------------------LESCGLT-----------------------------
----------------------------VAGCEDLSL-----------------------
--------------------------------AVINNKRLTH---LC-LADNI-LGD---
-------DGIKFVTDAL----KNPQC----------------------------------
--------------------------NLQ-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------SLVL--LGC-----ALTSTCCLDL------------
-------ASAI-LNNTHLRSLDLGHNDLQDYGVKV-LSEALR-HP-NC-NIERLG--LE-
--Y-CGLTSLCCQ--------------------DLSSVLRSNQNL-IKINLRQNTLGHEG
VMKLCE--------VLRSPECK--LK--V-------------------------------
---LGVCKE-AFDEEARKL------LE----------AVQ-VSNPHLIIKHDYTDHN---
--D---------------------------------------------------------
--------------------------------------------------EDGSWWRCT-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSMA----S

PF02758 // ENSGT00900000140813_0_Domain_0 (201, 328)

VRCK---LARYLEDLE--D---ADFKKFKMHLQD------
---------Y--PSQKG--------C--SPL-PRSQ-TEKAD-HMDLATLMIAFNGEEKA
WAMAVWI----FA-AINRRDLYEKAK-RDEPEWAGALHL-RAD---------NAHVV---
--------CR-----------------------------------EESL-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LGYLSRLSICKKKKDYCKKYKKH-
--------VRSR----------------FQCI--KDRNARLGESV---------NLNKRY
TRLRLVKEHQSQQEREHELL------AIGRTSAKMLD------SP--VSSLNMELLFE--
PEDQHSEPV----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

HTVVFQGAAGIGKTILARKI-----MLDWA--S---------EKIYQ
D--------RFDY-LFYIHCREVSLGT-------RRSLGD-LIVS-CC-----PD-PSPP
IHKIVS-KP----SRILFLMDGFDE-LQGAFDER------TE-A-----LCTNWQKV-ER
-GDILLSSLIRKRLLPEASLLIT-TRPVALEKLQHLL-D-----RPR--HVEILGFSEAK
RKEYF----------------F--KY-FSD---------EQQATEAFRLIQE-NEILFTM
CFIPLVCWIVCTGLKQQMDSGK-SL-AQ--T-SKTTTAVYVFFLSSLLQSCGENQKHQ--
------------VSANIRGLCSLA---ADGI-WN-QK----ILFEEC-------------
--DLRNHGLQRA-DVSAFLRM----NLFQKEVD-CE-KFYSFIHMTFQEFFAAMYYLLE-
EEKQ--------GGIRNLPRSGS--KLPNRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTSYLEKKLSCK---------------I--SQQ-IRL-ELLKWIKEKAK
AK-----------------------------------NLQIQPSQLELFYCLYEMQE-ED
FVQKAMGH---------------------F-------------------PKIEISLSTRM
---DHVVS--S----FCIE-NCHS-VES-LSLR----------------LLHN-----SP
KEEEEEEE----------------------------------------------------
---------------EVAQHSEVDHYVLLDP-----------------------------
------------------------------------------------------------
--------------------------HAAYT----H-----------RLV---------N
C-----------------------------------------------------------
--------HVT---IS-LWQ---GLFSVLSTNSL

PF00560 // ENSGT00900000140813_0_Domain_8 (1775, 1798)

TLTELNLSDNALGD-TGIKVLCEM--
LQR-PGCNIRRL-W----------------------------------------------
------------------------LGQCCLS-----------------------------
----------------------------HQCCFNISS-----------------------
--------------------------------VLSSNQ

PF00560 // ENSGT00900000140813_0_Domain_11 (2019, 2064)

KLVE---LD-LSHNT-LGD---
-------FGIRLLCVGL----RHLSCNLKKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSACCEDLASV-LSTSQSLTRLY
L-GENALGDAGVG-ILCEKAKHP--QCK----L---------------------------
-----------------------QKLGL--MNS-----GLTSGCCPAL------------
-------SSVL-STNQKLTHLYLRGNALGDTGMKL-LCEGLL-HP-NC-KLQILE--LD-
--G-CSLTSHCCW--------------------DLSTLLTSNK

PF00560 // ENSGT00900000140813_0_Domain_17 (2444, 2463)

SL-RELSLGSNDLGDLG
IMLLCE--------VLKQRGCL--LK--S-------------------------------
---LKLCGM-YFNYDTKCA------LE----------TLQ-EEKPELTIVFEPFW-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MADSSSSSFFP

PF02758 // ENSGT00900000140813_0_Domain_0 (202, 328)

DFG---LLLYLEELN--K---EELNTFKLFLK-------
---------E--TMEPE--------H--GLI-PWNE-VKKAR-RDDLANLMNKYYPGEKA
WSVTLKI----FG-KMNLKDLCQRAK-EEINWSAQ-SIGPDDAKV-GE------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------TQ-DQETVLGDGTEYRIR-
--------IKEK----------------FCIT--WDKKSLAGKPEDFHHGIV--------
----------------------------------------------EKDRKLLEHLFDVD
VK--TGEQP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 930)

QTVVLQGAAGVGKTTLVRKA-----MLDWA--E---------GNLYQ
Q--------RFMY-VFYLNGREINQLR-------ERSFAQ-LISK-DW-----PS-TEGP
IERIIS-QP----SSLLFIIDSFDE-LNFAFEEP------EF-A-----LCEDWTQE-HP
-VSFLMSSLLRKVMLPEASLLVT-TRLTTSKRLKQLL-K----N-HR--YVELLGMSEGA
REEYI----------------Y--QF-FED---------KRWATKAFSSLKS-NEMLFSM
CQVPLVCWATCTCLKQQMEKGG-DV-T--LT-CQTTTALFTSYISSLFTPV-GGCSPRLP
------------NQVQLRRLCQVA---AKGI-WT-MT----YVFYRE-------------
--NLRRFGLTKS-DVSSFLGN----NIIQKDTE-YE-NCYVFTHLHVQEFFAAMFYMLK-
GNWEA--------------GNPS--CQPFEDLK-SLLQSTSYK--DPQLRQMKCFL----
----FGLLNEDRVKQLERTFNCK---------------M--SLK-IKS-KLLQCMEVLGN
SD-----------------------------------YSPSQLEFLELFHYLYETQD-KA
FISQAMRY---------------------F-------------------SKVAINICEKI
HL---LVS--S----FCLK-HCRC-LRT-IRLS----------------VTT-----VFE
--K--KTL----KTSL-----PT--N------------------------TW---DGDRI
THWWQDLC-SVLHTNEHLRELDLCHSNLDKS---------AMNILH--QELRHP------
NC--K-LQKLLLKC---------ITF-PDGCQDISTSL----------------IHNQNL
MHLD-LKGS-DIGDN-GVKSLCEALKHPECK----LQTL--------RLE---------S
CN----------------------------------------------------------
---------LT---VF-CCL---SISNVLIR-SQSLIFLNLSTNNLLD-DGVQLLCEA--
LRH-PKCYLQRL-S----------------------------------------------
------------------------LESCGLT-----------------------------
----------------------------EAGCEDLSL-----------------------
--------------------------------ALISNKRLTH---LC-LADNV-LGD---
-------GGLKLMSDAL----QHAQC----------------------------------
--------------------------TLQ-SLV---------------------------
-------------------------------LRHCHFTSLSSEYLSTS-LLHNKSLTHLD
L-GSNWLQDNGMK-LLCDVFRHP--SCN----L---------------------------
-----------------------QDLEL--MGC-----VLTNACCLDL------------
-------ASVI-VYNPNLRSLDLGNNNLQDDGVKI-LCDALR-YP-NC-NIQRLG--LE-
--Y-CGLTSLCCQ--------------------DLSSALICNQRL-IKMNLTQNTLGYDG
ITKLYK--------VLKSPRCK--LQ--V-------------------------------
---LGLCKE-AFDEEAQKL------LE----------AVG-VSNPQLIIKPDYNYHN---
--E---------------------------------------------------------
--------------------------------------------------ENESWWRCF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------M---ASLFSDFG---F

PF02758 // ENSGT00900000140813_0_Domain_0 (209, 323)

MWYWKELN--K---VEFMKFKELLIL------
---------E--ILQMG--------L--KQI-SWTE-VKNAS-REDLAILLVKYCEGKQA
WDTTFKV----LQ-KISRHDLTERAT-GEI------------AA--------------HA
N---------------------------------------------------IYRA----
------------------------------------------------------------
----------------------------------------------------------H-
--------LKKK----------------LTRD--CSRKFSISIQNF--------------
---------------------------------F------------QDEYDHLENLLIPK
VT--EEK-P----Q

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 930)

LVFLKGIAGIGKTILLKNL-----MIVWS--E---------GLVFQ
N--------KFSY-IFYFCCQDVKQLK-------TTSLTE-LISR-EW-----PSS-SAP
IEEILS-QP----EKLLFIIDSLEG-MEWDFTKQ------ES-E-----LCDNCLEK-QP
-VNVLLSSLLKKKILPESSLLIS-ATFETFEELKDWI-E-----YTN--VRTITGFKESN
IKMYF----------------H--SL-FQD---------RNRALEAFSFVRE-NEQLFTL
CQAPVICCMVATCLKNEIEKGK-DP-V--SI-CRRTTSLYTTHIFNLFIPPN-VQYPSK-
-----------KSQDQLQGLCFLA---VEGM-WT-DI----SVFSEE-------------
--TLRRNGILDS-DIPTLLDI----GILEQSRE-SQ-NSYIFFHPSVQEFCAAMFYLLQ-
THMNH-----------------P--SPDVLHVE-KLLFSFLKE-VNTQWIFLGRFI----
----FGLLNELEHEKLEAFFGYQ---------------L--SQQ-LKQ-ELFEWLELLLD
P--------------------------------------EVKVNTMKFFYCLFEMEE-EV
FVQSAMNC---------------------R-------------------EEIDVVAKDYY
DF---IVA--A----YCLN-HGSA-LRD-LSIS----------------TQN-----VLN
-EKL--NQ-----------R-----------------------------------YMENL
LMLWHNIC-SVFARNKDIHILQMKDTIFNEP---------VFQILY--NYLKNS------
SC--I-LEVLVAND---------VSF-LCDKYLFFDL-----------------IQSYNL
ELLD-LSGT-FLSHS-DVVILCNILNKAEYK----IQEL--------ET-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------TAFNLW-----------------------------
----------------------------T--CVLFFY-YPC-------------------
--------------------------------IDFLTLKLDH---NG-LSTGP-SQ----
-------NAMPMRSLTLFHTECASLLILFAI-----------------------------
------------------------------------------------------------
------------------------------MLANCSLSEQSWKYISDV-LC

PF13516 // ENSGT00900000140813_0_Domain_13 (2212, 2237)

QNKTLRHLD
I-SSNDLKDEGLK-VLCKALTLP--DSV----L---------------------------
-----------------------LTLSV--KAC-----FITTVGCQYL------------
-------AEVL-R

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

NNHKLMFLTLSENKLEDSGVKL-LCDAIK-HP-RC-QLAQLD--LE-
--A-CELTGACCE--------------------DLASTFTQCKTL-GWINLVKNALDFNG
LVVLCK--------ALKQKTSN--LK--E-------------------------------
---LRLRIT-DFDNKSQTF------LL----------SEE-KGNKFLNIEND-E------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 328)

LLAILEELE--E---EQRKKFKFKLNT------
---------T--ELREG--------Y--KNI-PKGL-LQKAD-VTDMVDLLMKYYQEEYA
VEVVINV----LD-QINNKDLAERLR-RNV------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------NWKLILGGH-
PN----------------------------------------------------------
-----LKKHHQVEDKEHELL------SRGKRHMEIMR----KPSSFEDSHVKVEHLFDTL
SD--G-TIT----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 940)

RKVILQGVAGIGKTATVGKI-----MYDWS--C---------GTLYQ
G--------RFDY-VFHWSCRELNRRTE------KLSLVQ-LILQ-NW-GH-----PKPA
IGEILS-CP----SKVLFIIDGFDE-LRFPEDYD------ESKI-----LSCDLDTP-HS
-AAAVVESLLSSRSLSEACFLVT-TRPLAVAKLETHM-K-----ADL--WAEILGFLEED
RKEFF----------------K--KF-FKD---------EKKAAIAYHYIQE-NDVVFTM
CFVPLICWIVCTTLNLQMKHGE-EF-V--QK-VSTTTQIFTYFVATLLQSHGRS---QTS
------------TQNLFHNLGSLA---YAGM-RD-QK----VLFDES-------------
--MLRKCNLEVCKGPSTFLTE-----LLQGDIF-VE-TIYSFVHLSVQELFAALFTYWN-
KKEAF-----------------------------ELLKEAFVE-KKSHLILTVRFL----
----CGLNNDESLKPLKRYYETE------------------TGI-SKN-ELLKWIKKAL-
LIC----------------Q----------------GQEKQSNLLLELLHCLFEIQD-EE
FVIRALEE---------------------V-------------------KGLGFFVCLFL
FL-FCFVL--K----FTNG-MKRI-KYT-LDMR-----QRMKSLRTSNGR--Q----LWF
FESSNRD--------A--VHRIRFLNV-QSHL--RALCLDENSIDD--------------
------------------------------------------------------------
------------------------------------------------------------
--------------E-LMKTLCNSLNSTEYR----LQSL--------SLR---------S
NNLTQESIA-NICS----LFHC----NM-AVSLNLQSNSVGDEGVKILATCLKSKGCC-L
EKLSL-PGAGL--TED-CVP---AITSLFSQ-KNTLRWLDLSFNNLGD-GGVKALCSA--
LKD-KESRLEKL-I----------------------------------------------
------------------------LENNGIT-----------------------------
----------------------------NSCEKELIQLIET-------------------
------------------------------TP------SLQY---LC-LDNNE-FSST--
-------SRAHI------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------YDIWEEYHEEEE-------GGG-GR-D-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
--------------------------------------------TKVVEGLEL-GA----
---ATRLVTLSTGPTS------H------------F-------------------PHR-T
P---TSRPRVSMEE-KLLTFSIYG---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LRWCLDELD--K---EEFQTFKQLLKK------
---------T--SSEST--------T--CTI-PQSD-IENAN-VECLALLLHEYYGRSLA
WSTSIRI----FE-TMNLRTLSEKAR-DDMKSEQ-----GQL----------VPDRLDSW
LIT-QYIAVYSSPFSF--AEISQA--------------------------------VK--
QD-SAAAS---------EAEDREMSQPTEQGGA---------------------------
-----M---A-------------------------------AETEEQGPGGDTWNYKCH-
--------VMTK----------------LTAK--EDVP-CGFEKP---------------
-----------------------------------AA-------DWLEM-QMLVGAFGAD
Q---WGFRP----

PF05729 // ENSGT00900000140813_0_Domain_2 (674, 926)

HTVVLHGKSGIGKSALARRI-----VLSWA--Q---------GQLFQ
N--------MFSY-VFFLPIREVQRRK-------EASVAE-LISR-EW-----PD-SQVP
VTEIVS-RP----ERLLFILDGFDD-LGGSDVHS------DT-K-----LCRAWAER-QP
-TGALIHSLLRKVLLPESFLIVT-VRDVGVERLKSQV-V-----SPR--YLLVRGISAER
RIHLL----------------L--EH-GAG---------EHQKAQVARAMMS-NRGLLDQ
CEVPAVGVLVRVALQLQDVEGE-GV-------SLTLTGLYAAFVFHQLTPRD-VARRCLD
----------LEERAVLQRLCRMA---VEGV-WN-MK----SVFDRD-------------
--DLLIHGLGES-ELRALFGT----DVLLRDGH-CEEEHFTFFHLSLQDFCAALYYVLE-
GLDVE--------------PALC--PLFMEKGK-RSVELRQAG-FHSHLLGMKRFL----
----FGLMNEDVRRPLEVLLGCP---------------V--PL-GVKP-KLLHWVSLLGQ
QTD----------------------------------AT-APADTLDAFHCLFETQD-EE
FVRSALKG---------------------F-------------------REVWLPICETM
DL---TVS--S----FCLQ-HCPN-LRK-IRVD----------------VKG-----LFL
-RDESAEA----WP--------------------VV-----------PQ--WLRGK-TLV
DEQWENFC-SVLGTHPHLQQLDLGSSMLTER---------AMKTLC--AKLRP-P-----
AC--K-IQTLR--L-RNAQM---TH---GLR-HLWRTL----------------ITDRNL
RSLN-LGST-HLKEE-DVRMACEALKHPRCM----LESL--------RLD---------R
C------G----------------------------------------------------
---------LT---LT-CYL---KISQILTT-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1795)

SPSLSSLSLAGNEVTD-DGVKVLGEV--
FKV-AQCALQKL-T----------------------------------------------
------------------------LQDCGIT-----------------------------
----------------------------ATGCHSLAS-----------------------
--------------------------------ALVT

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2054)

SHSLTH---LC-LSNNH-LGN---
-------EGVSLLCRSL----RLPHC----------------------------------
--------------------------GLQ-RLM---------------------------
-------------------------------L----------------------------
------------------------------------------------------------
------------------------------VSC-----RLTAECCESL------------
-------SYVM-AR

PF13516 // ENSGT00900000140813_0_Domain_15 (2355, 2378)

SRYLRSLDLSDNAVGDVGVTA-LCEGLK-QR-KC-VLRRLG--LK-
--S-CGLTSGCCE--------------------ELSLALSC

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

NRHL-AGLNLAQNNFSPAG
MRKLCS--------AFACPTSN--LR--I-------------------------------
---IGLWKW-QYPVQIRKL------LE----------EVQ-LLKPRMVIDGSWYSFD---
--D---------------------------------------------------------
--------------------------------------------------DDRYWWKN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MKMA----STRCK---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LARYLEDLE--D---VDLKKFKMHLED------
---------Y--PPQKG--------C--IPL-PRGQ-TEKAD-HVDLATLMIDFNGEEKA
WAMAVWI----FA-AINRRDLY

ENSGT00900000140813_0_Linker_0_1 (323, 536)

EKAK-RDEPKWGSDNAH--VS---------NPTVI---
--------CR-----------------------------------EDSI-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LEYLSRISICKMKKDYRKK

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 657)

YRKY-
--------VRSR----------------FQCI--EDRNARLGESV---------SLNKRY
TRLRLIKEHRSQQEREQELL------AIGKT--KTCE------SP--VSPIKMEMLFD--
PDDEHSEPV----HTVVFQGAAGIGKTILARKI-----MLDWA--S---------GTLYQ
D--------RFDY-LFYIHCREVSLVT-------QRSLGD-LIVS-CC-----PD-PNPP
IHKIVR-KP----SRILFLMDGFDE-LQGAFDEH------IG-P-----LCTDWQKA-ER
-GDILLSSLIRKKLLPEASLLIT-TRPVALEKLQHLL-D-----HPR--HVEILGFSEAK
RKEYF----------------F--KY-FSD---------EAQARAAFSLIQQ-NEVLFTM
CFIPLVCWIVCTGLKQQMESGK-SL-AQ--T-SKTTTAVYVFFLSSLLQPRGGSQEHR--
------------LCAHLWGLCSLA---ADGI-WN-QK----ILFEES-------------
--DLRNHGLQKA-DVSAFLRM----NLFQKEVD-CE-KFYSFIHMTFQEFFAAMYYLLE-
EEKE--------GR-ANVPGSRL--KLPSRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTSYLEKKLSCK---------------I--SQQ-IRL-ELLKWIEVKAK
AK-----------------------------------KLQIQPSQLELFYCLYEMQE-ED
FVQRAMDY---------------------F-------------------PKIEINLSTRM
---DHVVS--S----FCIE-NCHR-VES-LSLG----------------FLHN-----MP
KEEEE--------E------------------------------------E---------
---------------KEGRHLDMVQCVLPGS-----------------------------
------------------------------------------------------------
-------------------------SHAACS----H-----------GLV---------N
S-----------------------------------------------------------
--------HLT---SS-FCR---GLFSVLST-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SQSLTELDLSDNSLGD-PGMRVLCET--
LQ----------------------------------------------------------
------------------------LGRCGLS-----------------------------
----------------------------HECCFDISL-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNQKLVE---LD-LSDNA-LGD---
-------FGIRLLCVGL----KHLLCNLKKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSACCQDLASV-LSTSHSLTRLY
V-GENALGDSGVA-ILCEKAKNP--QCN----L---------------------------
-----------------------QKLGL--VNS-----GLTSVCCSAL------------
-------SSVL-S

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

TNQNLTHLYLRGNTLGDKGIKL-LCEGLL-HP-DC-KLQVLE--LD-
--N-CNLTSHCCW--------------------DLSTLLTS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SQSL-RKLSLGNNDLGDLG
VMMFCE--------VLKQQSCL--LQ--N-------------------------------
---LGGTFF-FSSHSPLQC------STSYVLCHFLVYLLS-ISAPKI-------------
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---------------MNLLELVDWLS-HIC------------------------------
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----------------------------------------------LN--DYREMYREH-
--------VRC-----------------LE------ER---QEG----------GIRGSY
NQLLLVT-RSNPESADPSAC------PL-------PE-----Q-ELASV--SVETLFDPG
EE--SYQAP----P

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 940)

TVVLQGSAGTGKTTLARKM-----VLDWA--T---------GTLYP
G--------QFDY-VFYVSCREVVLLSE-------GTPDQ-LLFW-CC-GD-----NQAP
VKEMQR-EE----ERLLFILDGFDE-LQRPFATG------LK-R-----LS-----L-NP
-MENVLHRLIRREVFSRCSLLIT-TRPVAMCSLEPLL-K-----QSR--YIHILGFSEDE
RRRYF----------------S--SY-FAD---------EEQARNAFDIVQG-NDVLYKS
CQIPGICWVICSWLKEWMERGR-EI-S--ET-PSNGTDIFMAYVSTFLPPSH-NEDCAEL
----------T-SHRVLRGLCSLA---AEGI-QH-QR----FIFEEA-------------
--DLRKHNLDGASLD-AFLSS----MPYQEGGH-AK-TFYTFRHISFQEFFHAVSYLVK-
EDQSDL----------------G--KESHRELR-RLLEEEKEE-ENGEITLSMQFL----
----LDILKKETSSNFELKFFLK-----------------VSPS-LKQ-EL-MYFKEQM-
K-------------------------------------SIKHKRAWDLEFSLNPFKI-RN
LVKGIQIS---------------------D-------------------VSLKVGQSN-K
-K-SHDRK--S----FSVK-TSLR-DEQ-KEKQ-------------------G----PVV
--------GK---DNI--V-------------------KTQKE-----------------
------------------------------------------------------------
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----------------------------TSN----------------GKG---------R
-EMEK-------------------------------------------------------
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----------MRNPR----KQQFT---MK

PF02758 // ENSGT00900000140813_0_Domain_0 (210, 323)

DILKTLT--Q---AELSNFKSVLKN------
---------W--FLPHT--------L--KQI-PQIA-LNMAD-ADHVVEILHEYCPSDWI
EIIIKEV----LQ-TINQLDKAELVR-KQLEGKAF-KVAS----L---------------
------------------------------------------------------------
------------------------------------------------------------
---------L-------------------------------LLRFL--VGVILHKHKKK-
--------WKKE----------------YRVR--WKFNFWPKCIENFYV-----------
---------------------------------------------ETESYRTLLTLCNPK
A---KMPSA----H

PF05729 // ENSGT00900000140813_0_Domain_2 (675, 931)

AIVLHGPPNSGKTTMAMRL-----MLQWS--E---------SKQAQ
---------MFPC-AFFISCRAVNNTK-------SCTFAQ-LLSL-KS-----AS-RRDY
VEKSLA-LE----EKLLFVVDGFDE-LRVPAG------ALFQ-D-----ICSDWNTK-KP
-AAVLLSSLLKRKMAPHATLLVT-TQTQTLRQIYLMI-D-----QPF--LIENQGFSEQD
IQEYF----------------Q--RF-FNDEEGEEEDK-EEKAMRALNAVRC-NAALYDM
ASSPAASLIFCLCLEIAMKKGE-DL-A--LI-CQSQTSMFLNFLCKMFSPETYESYLKNI
------------FQISFKNLCLLA---VNNL-LE-QL----PILSKK-------------
--DLLELLLDRE-ILHPFLCR----YIVKSDD--YS-YCYSFVYLKVQQLLAAIAFADG-
LE--------------------N--DTSKYIMQ-NMLSKEARL-KNPNLSGVLLFI----
----FGLLNETRLQELATIFDWQ---------------I--SIG-VKR-KFLECE--PGE
NK-----------------------------------PFLLLMDLQEILSCLYESQE-EG
FVKEAMAL---------------------F-------------------EEISLHLKTNM
DL---MHA--S----FCLK-NSQN-LQT-VSLQ----------------VEKG----IFP
-END-DVL----ES--------------------TARDQG------------SQDD-QRL
LNFWTDFC-DMFHSNKKLVFLDISESFLSSS---------SLQILC--DKLSS-S-----
AC--H-LQKVV--L-KNISPA--DA----YK-KLCLIF----------------NGYETL
SHLT-LKGD-NLCT--ILPSLCGVVKHPSCK----LKYL--------SLS---------S
C------P----------------------------------------------------
---------TA---IQ-KWN---DFFQVLKV-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SQSLTCLDLTDNKLLD-QGIRLLCNT--
WKQ-PNNTLQRV-S----------------------------------------------
------------------------LENCHLT-----------------------------
----------------------------EGCCKDISS-----------------------
--------------------------------ILVV

PF13516 // ENSGT00900000140813_0_Domain_11 (2017, 2051)

SQTLTH---LN-LAKNT-LGD---
-------NGVKILCESL----SYPEC----------------------------------
--------------------------KLQ-TLV---------------------------
-------------------------------LWSCNITSDGCCHLSKM-LRQT

PF13516 // ENSGT00900000140813_0_Domain_13 (2214, 2237)

PSLKHLD
L-GQNCIRNAGAK-FLCEALKEP--HSN----L---------------------------
-----------------------KSLWL--CGC-----SMTPANCQDF------------
-------SKIL-RNNKSLNTLDLAQNSLGTDAIKT-FCEDLK-LG-IC-PLQTLR--LK-
--F-DDANPSIQK--------------------LIQKMKESHPQLTINSDQP----DPRK
---------------KEPSFPH--FI----------------------------------
----F-------------------------------------------------------
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-----------MKMA----STRCK---

PF02758 // ENSGT00900000140813_0_Domain_0 (208, 323)

LARYLEDLE--D---VDLKKFKMHLED------
---------Y--PPQKG--------C--IPL-PRGQ-TEKAD-HVDLATLMIDFNGEEKA
WAMAVWI----FA-AINRRDLY

ENSGT00900000140813_0_Linker_0_1 (323, 536)

EKAK-RDEPKWGSDNAC--VS---------NPTVI---
--------CQ-----------------------------------EDSI-----------
-----------------------------------------------------EEEWMG-
------------------L-----------------LEYLSRISICKMKKDYRKK

PF14484 // ENSGT00900000140813_0_Domain_1 (536, 657)

YRKY-
--------VRSR----------------FQCI--EDRNARLGESV---------SLNKRY
TRLRLIKEHRSQQEREQELL------AIGKT--KACE------SP--VSPIKMEMLFD--
PDDEHSEPV----HTVVFQGAAGIGKTILARKI-----MLDWA--S---------GTLYQ
D--------RFDY-LFYIHCREVSLVT-------QRSLGD-LIMS-CC-----PD-PNPP
IHKIVR-KP----SRILFLMDGFDE-LQGAFDEH------IG-P-----LCTDWQKA-ER
-GDILLSSLIRKKLLPEASLLIT-TRPVALEKLQHLL-D-----HPR--HVEILGFSEAK
RKEYF----------------F--KY-FSD---------EAQARAAFSLIQQ-NEVLFTM
CFIPLVCWIVCTGLKQQMESGK-SL-AQ--T-SKTTTAVYVFFLSSLLQPRGGSQEHR--
------------LCAHLWGLCSLA---ADGI-WN-QK----ILFEES-------------
--DLRNHGLQKA-DVSAFLRM----NLFQKEVD-CE-KFYSFIHMTFQEFFAAMYYLLE-
EEKE--------GR-TNVPGSRL--KLPSRDVT-VLLENYGKF-EKGYLIFVVRFL----
----FGLVNQERTSYLEKKLSCK---------------I--SQQ-IRL-ELLKWIEVKAK
AK-----------------------------------KLQIQPSQLELFYCLYEMQE-ED
FVQRAMDY---------------------F-------------------PKIEINLSTRM
---DHVVS--S----FCIE-NCHR-VES-LSLG----------------FLHN-----MP
KEEEE--------E------------------------------------E---------
---------------KEGRHLDMVQCVLPGS-----------------------------
------------------------------------------------------------
-------------------------SHAACS----H-----------GLV---------N
S-----------------------------------------------------------
--------HLT---SS-FCR---GLFSVLST-

PF13516 // ENSGT00900000140813_0_Domain_8 (1773, 1796)

SQSLTELDLSDNSLGD-PGMRVLCET--
LQH-PGCNIRRL-W----------------------------------------------
------------------------LGRCGLS-----------------------------
----------------------------HECCFDISL-----------------------
--------------------------------VLS

PF13516 // ENSGT00900000140813_0_Domain_11 (2016, 2054)

SNQKLVE---LD-LSDNA-LGD---
-------FGIRLLCVGL----KHLLCNLKKL-----------------------------
--------------------------------W---------------------------
-------------------------------LVSCCLTSACCQDLASV-LSTSHSLTRLY
V-GENALGDSGVA-ILCEKAKNP--QCN----L---------------------------
-----------------------QKLGL--VNS-----GLTSVCCSAL------------
-------SSVL-S

PF13516 // ENSGT00900000140813_0_Domain_15 (2354, 2378)

TNQNLTHLYLRGNTLGDKGIKL-LCEGLL-HP-DC-KLQVLE--LD-
--N-CNLTSHCCW--------------------DLSTLLTS

PF13516 // ENSGT00900000140813_0_Domain_17 (2442, 2465)

SQSL-RKLSLGNNDLGDLG
VMMFCE--------VLKQQSCL--LQ--N-------------------------------
---LGLSEM-YFNYETKSA------LE----------TLQ-EEKPELTVVFEPSW-----
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