Query Results 

----------------------PLSVFQGDHVWLDLHSTNKTGLAIGGLIKET-KPGKVL
VEDDEGKDHWIHTEDLGSLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVRNLLIRYRQHKIYTY
TGSILVAVNPFQMLPLYTVEQVRLYYNRQMGELPPHVFAIANTCYFNMQRSKRDQSCIIS
GESGAGKTETTKLILQFLAMVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYSMLLGMRAQDKELLCLGM
PSEYHYLTMGNCTSYEGLNDAKDYAHVCSAMKILQFSNSETWDLSKLLAAILHLGNVEFV
AAVFENLDSSDVGETPAFPTVMKLLEVQHQALRDCLIKHTILICGEYVTRPLNITQAIDR
RDAFAKGIYGHLFLWIVRKINTVIFTPPDQDPKHARRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSEGIAWDYIHYTDNRPTLDLLALKPVSIISLLDEES
RFPQ--GTDITMLQKLNSVH----ANNKAFLQPKNIHD--TRFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVHSSKNKFLREIFNLELAES-----------------------
--------TDSAKRPSTLAGQFKQSLDKLIKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVLIRKSGFPIRYSFAEFSQRFRVLLPSDVRA-QLKDKFREMTIGIADT
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDDQDSLLEIQRNQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAVSIQRVLRGYKH-RQE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYCDRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILVGFERLQAIARSHLLARQYQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RVVRLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVLVIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

QQRKASKLLWKILTLKLKITQEHDKDTG-G
KLGGTFWAERQETALSCLWPKGH----------EEEVPLVIPAAEEQKNESALPTTKR-K
SIYDTIT--DTEMVEEVFGFLPAMIGGQEGQASPLFKDLEAK--TQKLPEVDLDTVPMLE
E---PEEDMDDLAGYTFPKFAVTYFQKAASHTHIQQPLRYPLLYHEDDADCSAALAVWNI
ILRFMGDLPEPVLYARSR--QGSSVIQQLHHTLDREGSAQRLQQADGSSLIPILRPDRKD
KGTKEISSMKLKRSSRQPSLGFKVA----SQL-NTGEETFEPSGLVAD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NVRRSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFIDRGPAGYGPFCAERLRRTYANGVRMEPPTWLELQAVKSKKHIPIQVT
LVTGESLTI---TIDSASTSQEI--CHHIAHKQDLRDHLGFSL-----QIAVYDKFWSL-
GGGCDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
KLIYRQVLHGVWT-GEYSFEKEEGLVELLARHCYVQFGAL--AEDKAIQELLPSCVPPKL
YRTKLPEKWASLVTAAHSK-APYTQTQATRL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTMLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQQ-E--KMLLELSFPEVTR---------LASNRWGS---------------
-------QAMGLGR-----DKMGYYVV---------------------------------
------------------------------------------------------------
--PRAWEGLEWVGVGSPN--HTV--FLSREAQGSQRLLLSTLH-GEYELLSLSSVAITEM
VALFLEGLKERSVFAMALQDSPRP---AYDPTFL-PFKKGDLLVLKQKQGLLASE-NWVL
GHNDRTDKTGMVPMDCLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQLAEPPPEEQ-P
GKKPHTLEEFSYEF-FRAPEKGTASRAVKPLVSTRGHLWAYSPEPLRQPLLKRV----HA
NVDL-------RDIACQTFVA--TP----ILKYMGDYPSRQAWPT

PF00784 // ENSGT00900000140810_6_Domain_12 (2326, 2430)

LELTDQIFSLALQDS
SLQDEVYCQILKQL-THNSNRHSEDRGWQLLWLCTGIFQPSKVLLPHVQKFIDTRRGK-L
LAPDCSRRIHRVLRTGPRKQPPHQVEVEAAEQNVTHICHKVYFPNDTSE--MLEVCSNTR
VRDVCDSITTRLQLASWEGCSLFIKIADKQTQVISQKEGDFFFDSLRQVSDWMKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVVPGKDVKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNDRSQLASIPKILRELVPENLTRLMSSEEWKKS-ILLSYDKHKDKTVE
EAKVAFLRWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLATHPFTKISS
WSSGSTYFHMVLGSLGRSSRLLCETSLGYKMDDLLTS-----YVQQLLSTMNKQQGSKSL
P--------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
HLYK-

PF00784 // ENSGT00900000140810_6_Domain_7 (1326, 1368)

LKYLLNFINRGPASYGPFCAERLQRTCANGVRMEPPTWLELQAVKSKKHIPIQVI
LVTGQNLTV---MVDSASTSREV--CLHIAQKQDLTDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQVLHGVWS-GEYSFEKEEELIELLARHCHVQLGAS--SGSNAIQDLLPSCIPPKL
YKTKTPEKWTSLVTAAQAK-APYTKTGATAL-------------------------EVR-
QQVVDT---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAV
NWKGINFLDQR-E--RTVLELSFPEITS---------LVTDRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AWGGQRLLLSTLHGEEYEFTTPSSVAITEL
VALFLEGLKERSVFAMALQDQKATD----DVTLL-PFKKGDLLVLTKKQGLLTSE-NWTL
AQNDRTGKTGLVPTACLYAIPTVVKPSAQLLSLLAMSPEKRKLVAQEG-PSELLPEEQ-P
KEKPHTLEEFSY-KFFRAPEKETISRAMMPLGRTRGHLWSYSLEPLRQPLLKQV----HD
KADL-------RDIACQIFLDILPY----QLPYTGDYPSRQAWSTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSSALQEP
ALQDEVYCQILKQL-THNANRHSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-K
LASDCSRRIQVVLRTGPRKQPPHQVEVEATEKNISRICHKIYLPNDTSE--MLEVGTNHR
VREVCEAIATKLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GAA-ATLPYQVYFMRKLWLNVVPGKDMNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDQSQLSSVPKILRDLVPENLTRLMSSEEWRKS-LLLECNKHRNKTVQ
EAKVAFLKYICRWPTFGSAFFEVKQASEPSYPDIVLIAINRHGVLLIHPKSK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLSS-----YVQQILNVVNRHRGSQAT
ALAVL----------------------------------

MSALGCITCPTPELDGMVLTKNPMNWGGGDHVWLNPLPANKTSVAIGCIIKET-KPGKIL
VEDDEGKEHWIRAEDIDTLSPMHPNSMQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLSEADMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNHHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLQGMSAEEKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMETPAFPIVLKLLEVKWQALRDCLIKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVRHVFTMEQEEYLSEGIAWDYIQYSDNRPTLDLLALKPMSIISLLDEES
HFPQ--GTDTTMLQKLNSVH----ANNKAYLQPKNIHD--ARFGIAHFAGKVYYQTEGFL
EKNRDV---LSTDILTLVYSSENKFLKEIFKLESAGTKMGHGTIIRAKAGS--QL-----
----FKS-ADSGKQPSTLAGQFKKSLDQLMKILTSCQPYFIRCIKPNEYKKPLLFDRELC
IRQLRYSGMMQTVYIRKSGFPIRYTFDAFSQRFRVLLPSAVRF-QLRDKARQMTLRIAET
WLGTDKEWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDKQDTLLELQRSEMLN

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAVSIQKVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRGYYNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KQILLGFERLQAIARGLLLAKQYQMMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

RQQKANGL----------------------
--------------------------------------LV-LPARKQKSQDAVPTRKR-K
SIYDSVI--DTEMVERVFGFLPSVIGGQEGQSPRDFEDLEAR--TQKLPEVDLDTVPMVE
E---YEEDVDGLAEYTFPKFAATYFQKSASHTHIRRPLRYPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPVLLARNGLRGS-SMMQHLHDTPGGENSTRSPQQRG--------------
--------------------STQVT----SQL-NIGEEAFDPDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPN--LRDEIYCQ-ICKQLSE-NFKMSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGKGPAGYGPFCAERLRRTYANGVRTEPPAWLELQAVKSKKHIPIHVI
LVTGESLIV---MVDSASTSREV--CLHIAHRQGLSDHVGFSL-----QVAVYNKFWSL-
GSGRDHVMDAVAQCEQLARERGENER-----QSPWRIYFRKE--F-FTPWHNSQEDSIST
QLIYRQILHGVWS-GEYSFEKEEELLQLLARHCYVRLGAS--LRSEAVQELLPSCVPSRL
YKTKPPEKWASLVTAAHAK-AQYTQKQAKPL-------------------------AVQ-
EQVVEA---AR-----------------------------------------LQWPLLFS
RLFELTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGMYFMDKK-E--KMLLELSFPEVMS---------LITNREAQ---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLLLSTLHQEEYEFMSPSSVAIAEL
VALFLDGLKERSVFAMALQDRKATEDA----TIL-PFKKGDLLILTKKQGLLASE-NWTL
GQNDRTGKTGLVPTACLYAIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPPEPLPEEQ-S
KEKPHTLEEFSYEF-FRDPEKETVSRAMLPLARTRGHLWDHSSEPLRQPLLKRV----YA
NTEL-------RDPACQ-I-F--IA----ILRYMGDYPSRQAWTPV

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

DLTNQIFSLALQES
ALQDEVYCQILKQL-THNTRRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-P
LAPDCSRRIQRILRTGPRKQPPHLVEVEAVEQNITRICHKICFPNDTSE--MLEVGTYTR
VRDLCQSVATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLREVSDWVRKNKPQK
E----GAP-ATLPYQVYFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSQEDAV
HLAGLIYKAQFDNDRSQLASIPKILRQLVPENLTRLMSSEEWKKN-ILLAYDKNKNKTVE
EAKMAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLARGSRLLCETSLGYKMDDLLTS-----YVQQFLSTMKKQRGSQAP
TDP------------------------------------

----------------------MSVFRLGDHVWLDPPSSSKTGVAIGGIVKET-KLGKTL
IEDDEGKEHWVCAEDLSTLRPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSPEEKQMLSLGM
PSEYHYLTMGSCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFPLAMKLLEVQHEALRDCLIKHTIPVLGEFVSRPVNIAQATDR
RDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSIH----ANNKSFLSPRSIHD--TRFGIAHFAGDVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQVK--AGSQL-----
----FKS-SDSTKRPVTLASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERM-QFQNKPRQMTLHIADL
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTVLEIRRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAIRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYSQRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILVGFERLQAIARSHLLMRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVIIQAHARGMVVRKS

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YWQQK--------------------------
-----------------------------------STGPQVILAKEPKAQGAVHERKR-K
SIYDTVT--DTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLHEVDLDTVPMMA
M---PEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALAVWII
ILRFMGDLPEPVVYGRDSLTGS-SVMRQIHDKLGKDSVTQ---RNRS-------------
---------------------SQVA----SQL-NFGEETFKFDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGKSLTI---SVDSASTSREI--CQHVAQKQGLRDNLGFSL-----QVAVYDKFWSL-
GSGCDHLMDAVAQCEQLARERGESQR-----QAPWRIYFRKE--F-FTPWHDSREDPVST
ELIYHQVLRGVWS-GEYNFEKEEELVELLARHCYVQLGAT--VKSNAVQELLPSCVPSKL
YRTKSPEKWASLVTAAHAK-AQYTQSKATPL-------------------------AVR-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGMYFLDQK-E--RTLLGLSFAEVMG---------LVANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGKKLLLATLQ-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRRATD----DITLL-PFKKGDLLILTKKQGLLASE-NWAL
GQNDRTGKTGLVPTACLYTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVRAPEPPLEEQ-L
TESPYTLEEFSYQ-FFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSV----HD
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLALQDP
ALQDELYCQILKQL-THNSIRFSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKK-P
LALDCSRRLHRVLRVGPRKQPPHHVEVKAAEQNVSKLHHEVYLPNDTSK--TMEVGSSSR
VRDLCEGIATRLQLASWDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAS-VTLPYQVFFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLGGLICKIQFGSDSSQLASVSKVLKELVPQNLTRLMSSEEWKKS-LLLECDKHKRKTVA
EAKVEFLKYIYRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYPFTKISS
WSSGNTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQLLNTVNKQRGFRAP
ALANP----------------------------------

----------------------MSVFRLGDHVWLDPPSTSKTGVAIGGIVKET-KLGKVL
IEDDEGKEHWICAEDLSTLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLVRYQQHKIYTY
TGSILVAVNPFQMLPLYTPEQVQIYYSRHMGEQPPHVFAIANSCYFNMRKNKRDQCCIIS
GESGAGKTESTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSPEEKKLLGLGM
ASDYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILHFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETSAFSFAMKLLEVQHQALRDCLIKHTIPIRGEYVSRPLNMAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPQSVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWDYIHYTDNQPILDLLAVKPMSIISLLDEES
RFPQ--GTDATMLQKLNSVH----ANNKFFLRPRNIHD--TRFGITHFAGEVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNLESPQAKLGHGTIRQMKAGS-QSA-----
----FKP-SDSTKRPLTLAGQFKQSLEQLMRILTHCQPYFIRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVQIRRSGFPIRYTFDEFSQRFRVLLPSPEQK-QFQDKHRQMALRIADL
CLGTDKDWKMGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIRRSQVLDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAISIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RQ-
--AAVTLQAVWRGHCQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 892)

F-ELILVGFRRLQAIARSRLLMRQFQTMRQKL

PF00612 // ENSGT00900000140810_6_Domain_5 (892, 907)

VQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVIIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

RQQK--------------------------
-----------------------------------SIGPPVILANEPKGQGAVPDRKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLLEIDLDTVPMTE
M---PEEDVDGLAEYTFPKFAATYFQKSASHTHIQKPLRYPLLYHEKDTDHLTALAIWPI
ILRFMGDLPEPVLYARNSLSGS-SVTKQIRDRPGKDRDTQGPEHTEY-------------
---------------------AQVA----RKL-KTGEEAFKSDVPVSD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKKSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGGSLTI---SVDSASTSREI--CQHIAQKQGLRDHLGFSL-----QVAVYDKFWSL-
GSGCDHVMDAVAQCEQLARERGESQR-----QSPWRIYFRKE--F-FAPWHDSQEDPVST
ELVYWQVIRGVWS-GEYSFEKEEELVELLARHCYVQLGAT--VKSDAVRELLPSCVPSKL
YRTKSPEKWASLVTAAHAK-APYTQSRATPQ-------------------------AVR-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGMCFLDQK-E--RTLLELSFAEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRLLLSTLH-EEYEFVSPSSVAIAEL
VALFLGGLKERSVFAMALQDRKATD----DATLL-PFKKGDLLILTKKQGLLASE-NWIP
GQNDRTGKTGLVPVACLYIIPSVTKPSAQLLSLLAMSPEKRKLAVQEVRAAE-LPEEQ-P
AESPYTLEEFAYQ-FFRTPDKETISRATMPMARSRGHLWAYSPEPLRQPLLKCV----HD
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLAQQDP
ALQDELYCQILKQL-THNSIRYSEERAWQLLWLFTGLFPPGKMLLPHAQKFIDSRRKK-P
LAPDCSRRLHRVLRMGPRKQPPHHIEVKAAEQNASKLCHEVYFPNDTSE--TMEVGSSSR
VRDLCESIATRLQLASLDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAA-MTLPYQVLFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDVI
HLAGLIYRVQFGSDRSQLASVSKILKELVPQNLTRLMSSEEWKKS-LLLECDKYQHKTVA
EAKVDFLKWIYRWPTFGSSFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYPFTKISS
WSSGSTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQLMSVVNKQRGPRAP
ALANP----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_1 (90, 180)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYLNMKRNKRDQCCII

ENSGT00900000140810_6_Linker_1_0 (180, 237)

S
LAT--------------------------------------------------SSE

PF00063 // ENSGT00900000140810_6_Domain_0 (237, 798)

HRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFAMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDLTMLQKLNSVH----SNNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLREIFNLESAETRLGHGTIRQAKAAN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFEEFSQRFGALLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTVQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1265)

QQRR--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQASPRFEDLESKTQ--KLPEVDLDTVPMVD
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQAPQH-RF-------------
---------------------AQVA----SQL-NIGEEALEPDGLGAD-------RPMSN
LEKV

PF00784 // ENSGT00900000140810_6_Domain_7 (1265, 1368)

HFTVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CLHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESQAVQELLPSCVPHRL
YRTKPPDRWASLVTAACAKVTPYAERQATPL-------------------------SF--
------------------------------------------------------------
---TTLSGN-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DTTLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLTMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIAST---PIL--------RYMGDYPSRQARPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVTPGKIVS------TTQELPKYLH---------AI
HLAGLIYKASSNKTRSQLASVPKILRELVPKDLTHDV-LEEWKKH-PSAYDKATKDKTVA
MSPRGLQKWICRSAHLGPASLSLCPTPGPPAQQALLISPRTL-------PTH--------
-------------------------------PLCPQDL-----------LTTYPFTKISS
WSSGSTYFHMVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_1 (90, 180)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCII

ENSGT00900000140810_6_Linker_1_0 (180, 237)

S
LAT--------------------------------------------------SSE

PF00063 // ENSGT00900000140810_6_Domain_0 (237, 798)

HRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGELVTRPLNIVQAADR
KDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFAMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLVDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFEEFSQRFGALLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTVQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQAPQH-RF-------------
---------------------AQVA----SQL-NIGEETLEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERSESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--VESKAVQELLPSCIPHRL
YRTKPPERWASLVTAACAK-APYAERQATPL-------------------------AVR-
EQVVDA---AC-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTF
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLTMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIAST---PIL--------RYMGDYPSRQARPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-TQNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNITPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLANVPKILRELVPKDLTRLMSSEEWKKS-IRLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAISRRGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAAMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAVANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFMATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSVEDKQLLSLGT
PSEYHYLTMGNCTSCERLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASEVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNQAFLQPKNMYD--ARFGIAHFAGEVYYQVEGFL
EKNRDV---LSTDILTVVYSSKNKFLREIFNLESAETRLGRGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELG
LRQLRYSGMMETVHIRKSGFPIRYAFEEFSQRFGVLLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLVRQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPCFEDLELKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIQRPLRYPLLYHEDDADCLAALTVWNV
ILRFMGDLPEPVLYARSSQQGS-SMMRQIHDTLSRGHGAQAPQHSRF-------------
---------------------AQVA----SQL-NIGGEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPLQVI
LATGESLTV---SVDSASTSQEM--CVHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEQELVELLARHCYVQLGAS--AESQAIQELLPSCIPHRL
YRTKPPDRWASLVTAACAK-APYTQRQATPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVAKRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFASPSSVAVAEL
VALFLEGLKERSVFAMALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
SQNDRTGKTGLVPMACLYTIPTVTKPSAQLLVTGTLPCPQEP---QGGRAPRCQPRDA-S
QAAPGRR-AYRLSMAWAAPWAR-----VGPAAHLPGPIL--CQPALRQPLPLKRGSSTRP
TLPS-------ADIACQIF---------------GRRYPSAAWPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFMAGP---
A--------ILKQLTTTPTGLHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRHIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYFPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLSYQVYFMRKLWLNITPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
------------------------------------GL-----------LTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALAST----------------------------------

----------------------MSGLRLGDHVWLGLPSNHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDFGALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQQKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGDLPPHVFAIANNCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEQSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGM
PSEYHYLTMGNCTSCEGLDDAKDYAHIRSAMKILQFSDSENWNLSKLLAAILHLGNVGFI
ASVFENLDSSDLMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNVAQAADR
RDAFVKGIYRHLFLWIVKKINAAIFTPPPQDPKNVWRAIGLLDIFGFENFKNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYHSENISWDYIHYTNNRPILDLLALKPMGIICLLDEES
RFPK--GTDLTMLQKLNSVH----TNNKAFLQPKNVHD--ARFGIAHFAGDVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLKEIFNLELAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSSKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFQEFSQRFGVLLPGAVRM-QLRDKFRQMTLGITDM
WLQTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQMLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYYNRRNF-KLILVGFERLQAMVRSQLLARQYQAMRQRMVQLQALSRG
YLVRQQVQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RKAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ASVPLVIPAEAQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPHFEDLESKTE--KLPEVDLDAIPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGG-SVMRQIHDTLGREHGAQALQHGGSAQ-----------
-----------------------VA----SQL-SIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFISQGPATYGPFCAERLRRTYANGVRVEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESHR-----QSPWRIYFRKE--F-FTPWHNSQEDPVST
ELIYRQVIHGIWS-GEYSLEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCVPRKL
YRTKPPDRWASLVTAACAK-ASYTQKQATPL-------------------------AVR-
EQVVDA---AL-----------------------------------------LQWPLLFS
RLFEVITLS-GSRL----------------------------------------------
----------------PKTK----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQKLLLSTMH-EEYEFVSPNSVAITEL
VALFLEGLKERSLFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTF
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQPEELQTKEP-P
KEKPHTLEEFSYE-FFRAPEKETGSRAVLPLSRARGHLWAYSSEPLRQPLLKQV----HA
DIDL-------WDVACQIFVAIL--------RYMGDYPSRQAWPTV

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHE
ALRDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKGLLPHAQKFIDTRRGK-L
LAPNCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRICHKIFFPNDTSE--MLEVGANTR
VRDMCDSIATRLQLASWEGCSLFIKITDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNDQSQLASVPKILRELVPENLTRLMSLEEWKKS-IPLAYDKHKDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRRGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMDKQRGSKAPALAST
---------------------------------------

---------------------------------LDPPSANKTTVAIGGIIKKT-EPGKVL
VEDDEGKEHWICAKDLGSLSLMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQNKIYTY
TGSILVAVNPFQALPLYTLEQVQLYYRHHVGELPPHVFAIANSCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVHNDNSSRFG
KYIDIYFNHSGVIEGARIEQFLLEKSRVCRQAPDERNYHIFYCMLMGMSAEEKRLLCLGM
PSEYHYLTMGNSSSCEGLDDAKDYAHIRSAMKILMFSDSENWDISKLLAAILHLGNVEFM
AAVFENLDSSDVMEPSTLPIVMKLLEVQHQALQDCLTKHSIIIRGEFVIRPLNITQAADR
RDAFVKGIYGHLFLWVVKKINAAIFTPPSQDPKHVRRAIGLLDIFGFENFQSNSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYREEHIAWDYIHYTDNRHTLDLLALKPMSIMSLLDEES
RFPQ--GTDITMLQKLKSVH----AHNKAFLQPKTIHD--VRFGIAHFAGEVYYKTEGFL
EKNRDV---LSTDILSLVYSSNNKFLKEIFKLEATETK----------------------
--------TAEAKRPPTLAGQFKQSLDQLMKILTTCQPYFIRCIKPNEYKKPLLFDRELC
LQQLRYSGMMETVQIRKSGFPIRYTFEEFSQRFQVLLPSAMRM-QLRDKFQQMTLCIADM
WLKTDKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDHQDTLLEIQRSQAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

DAAALSIQRVLRGYKH-RKEF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

KW-
--AAVTLQANWRGFSTRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILLGFERLQAIARSHLLARQYEAL

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RERIIRLQAQCRG
YLIRRTA

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QER

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVIIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

RRRKANWQEEVYLAS-VRCAAAS-------
------CL--------SLS-TVRPAVT-FLH-GCMQGPLV-IPAAQQRDPSAPPAKKR-E
SIYDTVT--DTEMVEKVFGFLPSMIGGQEGQAPPRFEDLETR--TKQLPEVDLDTVPMVE
E---TEEEAYGLAEYTFPKFAATYFQKSASHTHIRRPLRHPLLYQEDDADCEAALAVWGI
ILRFMGDLPEPVLFARTKRRDS-SAIQQIHNTLGAEGSTQPPQSGGSAQ-----RPSHRD
RGTKEISSMKLKRSSRI---TSQVV----SQL-SIEKEAFELNGPISD-------QP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVHFIVAHAILRPN--LRDEIYCQ-ICKQLSE-NFKMSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPAGYGSFCAERLRRTYANGVRMEPPTWLELQAVKSKKHIPIHVI
LVTGESLII---MVDSASTAREV--CLHIARKQGLSDHVGFSL-----HVAVYDKFWSL-
GSGRDHIMDAIAQCEQLARERGESER-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEREEELVELLARHCYVQLGAS--AGSEAIQELLPSCIPTKL
YRTKPPEKWASLVAAAHTK-APYTQKQATAL-------------------------AVR-
EQVVDM---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PRAK----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KLLLELSFPEVTG---------LVTNRTAR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLTLSTLREEEYELATPSSVAIAEL
VAMFLEGLKDRS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2180)

VFAMALQDSPTP-APRDDATLL-PFKKGDLLILTKKQGLLASE-NWTL
GQNDRTGRTGLVSTACLYI

ENSGT00900000140810_6_Linker_10_12 (2180, 2323)

IPTVVKPSAQLLSLLAMSPEKRKLVAQERRPAEPSPEEQ-P
KEKVHTLEEFSYEF-FRAPEKESVSKAMFPLARTRGHLWAHSSEPLRQPLLKRV----HA
NADL-------RDCACQ-T-F--LP----ILKYMGDYPSRQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

WSSLELTDQIFSLALQEE
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKELLPHAQKFVDTRRKK-Q
LAPDCSRRLQRVLRVGPRKQPPHQVEVEAAEHNVTRICHKVYFPNDTSE--MLEVGTNTR
VRDACQSIATKLQLASWEGCSLFVKIADK---VFSQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTVPYQVFFMRKLWLNVSPGKDVNADTILHYHQELPKYLRGFHKCSREDVL
HLAGLIYKAQFDNDRSQLASIPKILRQLVPENLTRLMSSEEWKKESIPLAYDKHVDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIVLIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKIAS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLTTMNRQRGSRAP
D--------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------

PF00784 // ENSGT00900000140810_6_Domain_7 (1328, 1370)

YLMNFINQGPAGYGDFCAERLRRTYANGVRLEPPTWLELQAV

ENSGT00900000140810_6_Linker_7_8 (1370, 1373)

KTK

PF00788 // ENSGT00900000140810_6_Domain_8 (1373, 1417)

KHIPVNVI
LVMGESVTI---TVDSASTAKEV--CQHIAQKRGLRDHLGFSL-----HMAVYNKFWSL-
GSGHDYVMDAV-ACEQLARERGESEC-----QSXXXXXXXXXXXX-XXXXXX--XXXXXX
XXXXXXXXXXXXX-XXXXXXXEEDLLGLLARHCYVQLGSGTSPENAAIQELLPTCVPTKL
YRSKPPEQTSL-IAATWPKXXXXXXXXXXXX-------------------------X---
------------------------------------------------------------
-----------XXX----------------------------------------------
----------------XXXXXXX-------------------------------------
-------------------------------------------------------XXXXX
XXXXXXXXXXX-X--XXXXXXXXXXXXX---------XXXXXXXX---------------
------------------------------------------------------------
------------------------------------------------------------
------XXXXXXXXXXXXXXXXX--XXXXAARGQQSLRLSTLHEEEYEFATPSCVAIAEM
VAMFLEGLKERS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2180)

TFAMALQDRKATD----DPTLL-PFKKGDLLVLMEKQGQQASD-KWTL
VQSNRLGRTGLVPTACLYI

ENSGT00900000140810_6_Linker_10_11 (2180, 2323)

IPTVVQPSERLLSLLAMSPEKRKLAGRQGRPADVLPEEQ-P
QEKPHTLEEFSQQ-FFRAPEKETISKATMSWASTRGHLWTHSSEPLRQPLLKSV----HA
IADL-------WDIAYQTF-----R----ILKYMGDYPSRQS

PF00784 // ENSGT00900000140810_6_Domain_11 (2323, 2358)

WSSVELTDQIFSAALQEV
VLQDEVYCQILKQL-TNNSNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXLGPRKQPPHQVEVEAAEQNITRIRHKVCFPNDTSE--MMEVGTSSR
VRDVCQSITAKLQLASWEGCSLFVKIADKXXXXXXXXXXX---XXXXXXXXXXXXXXXXX
X----XAP-VTLPYQVFFMRKLWLNVTPGKDVKADTILHYHQELPKYLRGFHKCSREDVL
HL-SLIYKVQFDNDRSQLANVPKILRQLVPENLTRLMTSEEWKKS-IPLAYDKHTDKTVE
EAKVAFLKRICRWPTFGSAFFEVKQTSEPSYPEIVLIAINRFGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKIAS
WSSGSTYFHMVLGSLGHGNRLLCETSLGYKMDDLLTS-----YVQHFLGTVNKQRSSQAP
VLASF----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------

PF00063 // ENSGT00900000140810_6_Domain_2 (690, 798)

MKILGSCQPYFIRCIKPNDYKKPLLFDRELC
TRQLRYSGMMETIRIRKAGYPIRYSFAEFFERYRALLPVSARE-QLQGDARRCCIYISET
VLGKDEDWKTGRTKIFL

ENSGT00900000140810_6_Linker_2_3 (798, 816)

KDYHDMVLEVQRDKALTE

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

KVILIQKVLRGFKD-RKQ

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVKLQAAWRGYYGRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

RLVLLGFERLQSLFRSRQLAKQYKTA

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 906)

RASVVKFQALCRG
YLMRK

ENSGT00900000140810_6_Linker_5_6 (906, 912)

KTAEQM

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 932)

KAVCVIQAYARGMFVRRSF-

ENSGT00900000140810_6_Linker_6_7 (932, 1259)

QRMKREHQHRLEARRLGLEEEKRLIPIIG
SMRAK---------------------QEAMKLEKEHLAALER---EEEQRKHNSLSDK-Q
PLYDAIS--DQEMVDKMFGFLPTVIGGQEGQSPLGFEDLEAKA--GMLDEVDLDMLPMSV
QLEE---EVDDLAEYTFPKFAATYFQGSSTHTHMRKPLRHPLLYHDEKDDILASLAVWNI
ILRFMGELSEPVMFAKNTNSKSSSVMTQIYDTLGKKSQVQLTGN---NTPQPG-GYRRDN
RLSKGISSVKLKRSSKL---TGKVV----SQL-NSREELIQEQSTISD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1327)

SN
LEKVHFVIGNAILRPA--IRDEIYCQ-ICKQLSE-NNNKSSRARGWILLSLCLGCF--PP
SDKF-VKVSCPRSLDQA-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEA-KPGKVL
VEDDEGKEHWIQAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVTKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRM-QLQGKFRQMTLGITDV
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

RQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-R
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQASPRFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQRSASHTHIRRLLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSSQQGS-SVMRQIHDTLGREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREM--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIAQCEQMAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLQGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQKQVTPL-------------------------AMR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQQ-E--KMLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALLLEGLKERSIFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DTTLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPMAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEP-P
KEKLHTLEEFSYE-FFRAPEKDMVSMAMLPLARARGHLWAYSCEPLRQPLLKR----VHT
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQKVVRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLREVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNISPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQRGSKAP
ALAST----------------------------------

----------------------MSVFRLGDHVWLDPPSTSKTTVAIGGIVKET-KPGKVL
IEDDEGKEHWIHTEDLSNLRAMHTNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLVRYKQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHVFAIANSCYFSMKKNKKDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEDKKLLGLGM
PSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILHFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFSFAMKLLEVQHQALRDCLIKHTIPIRGEFVSRPLNIAQATDR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPQSVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQTILDLLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSVH----ANNKSFLKPKNIHD--TRFGIVHFAGEVYYQVEGFL
EKNRDT---LSTDILSLVHSSKNKFLKEIFNLESQQIKLGQGTIRQMKAGS-Q-H-----
----FKS-SDSTKRPLTLTGQFKQSLDQLMKILSQCQPYFIRCIKPNEYKKPLLFDRELC
IRQLRYSGMMETVQIRKSGFPIRYTFEEFSQRFRMLLPSPERK-QFQDKHRQMTLRIADR
CLEADKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RR-
--AAVTIQAAWKGHCQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 889)

F-ELILVGFKRLQAIARSHQLMRQFQTMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVVIIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQQK--------------------------
-----------------------------------TIGPQVILANEPKDQGAVPDRKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGPSPTRFEDLEVKTQ--KLPEIDLDTVPMME
M---PE-DLDGLAEYTFPKFAATYFQKSASHTHIQKLLRYPLLHHENNTDHMAALAVWPI
ILRFMGDLPEPVLHARNS-----SVMQQNHDRLGKDSGTQGPQHNGY-------------
---------------------AQVA----RKL-NIGEEAFKPDVPVSE-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAITRPG--LRDEVYCQ-ICKQLSE-NNKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFLGQGPGSYGPFCAERLQRTFTNGVRSEPPTWLELQAVKSKKHIPIQVV
LATGGSLTV---SVDSASTSREI--CQHIAQKQGLRDHLGFSL-----QIAVYDKFWSL-
GSDCDHVMDAVAQCEQLAQERGESQR-----QAPWRIYFRKE--F-FTPWHDSREDPVST
ELIYCQVLRGVWS-GEYNFEKEEELVGLLARHCYVQLGAT--VKSDAVRELLPSCVPSKL
YRTKSPEKWASIVTAAHAK-APYTQSKATPL-------------------------AVK-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGMYFLDQK-E--RTLLELSFTEVMG---------LIANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRMLLSTLH-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRKATD----DATLL-PFKKGDLLILTKKQGLSASE-NWVP
GQNDRTGKTGLVPMAYLYIIPSITKPSAQLLSLLAMSPEKRKLATQEVRAAEPLLEEQ-A
TESPYTLEEFSYQ-FFRAPDKETISRAAMPMARSRGHLWAYSPEPLRQPLLKCV----HE
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLAQQDT
ALQDELYCQILKQL-THNSIRYSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKK-P
LAPDCSRRLHRVLKMGPRKQPPHHVEVKAAEQNVSKLRHEVYLPNDTSE--TMEVNSSSR
VRDLCEGIATRLKLASLDGCSLFIKITDK---VISLKEGEFFFDSLRQVSDWVKKNRPQK
E----GAP-ITLPYQVFFMRKLWLNVTPGKDMNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDVI
HLAGLIYRVQFGCDQSQLASVSKILKELVPQNLTRLMSSEEWKKS-LLLECDKHKNKTVA
EAKVEFLKWICRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYTFTKISS
WSSGSTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQIMNAVNKQRGFRAP
ALANP----------------------------------

----------------------MAVFKQGDHVWVSLFSNKENGVPIGAVVKDNTYPNKIL
IQDDEGKERWIEAQNFKSLQPMHPSSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 708)

VEDMILLGDLNEAGLVHNLLIRYQKNKIYTY
TGAILVAVNPYQVLPIYTMDQIQLYHNQRVGQLPPHVFAIADSCYFDMKKNKRDQSCIIS
GESGAGKTETTKLILQFLAIISGQHSSIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIEIHFNQNGVIEGAQIEHFLLEKSRVCRQAPEERNYHIFYCMLLGMNEEQKKLLSLGT
VSEYKYLTMGNCMSCEGRNDVKDYASLRSAMKVLMFSDSENWNISKLLASILHLGNVEFS
AAVSDNLDCSDVMPTSHFLAAVKLLEVKNMELQSCLTNHYIIIRGEGVSRPLNILQASDR
RDAFVKGIYGHLFLWIVNKINSAIFNKPSQDPQNVRRSIGLLDIFGFENFHTNSFEQLCI
NFANEHLQQFFVRHVFTMEQEEYHRENITWNYIHFNDNRPILDLLALKPMNIISLLDEES
KFPK--GTDATLLQKMNHLH----SNSKIYVAPKNIHD--TKFGIVHFAGLVHYQAEGFL
EKNRDV---LSTDIIKLIYSSKNNFLRQIFQLELSETKLGRGTIRQATFPDT--------
----LSKNADATKRPPTLASQFKQSLDSLLKILKHCQPYFIRCIKPNEF-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

---------------------FHIFRILGDHVWLEPASTNKTEVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDFGVLSPMHPNSVEG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 713)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQLYYGRHVGELPPHVFAIANSCYFSMKKNKKDQCCVIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNTSGVIEGARIEQFLLEKSRVCRQAAEERNYHIFYCMLMGMSVEEKKLLGLGM
PSEYHYLTMGNCTSYEGLNDAKDYAHVRSAMKILLFSDSENWDISKLLAAILHLGNVEFM
AAVFENLDSSDVMETPAFPIMMNLLEVQYQALRDCLIKHTILIRGEYVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFPPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RLPQ--GTDITMLQKLNSVH----ANNKAFLKPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDM---LSADILTLVYSSKNKFLREIFNLESAETKLGHGTIRQAKTRN--QF-----
----FKG-TDSTKRPSTLASQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLVSRNL--
----EHPNILPM----------------VSVPNGTEPPPVFPV-QLQDKFRQMTLCITEV
CLGTDKEWRVGKTKIFLKDHQDTLLEIQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

EAAIRIQRVMRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAEWRGYCSRKNF-KLILVGFERLQAIARSHLLMRQFQATRQRMVQLQARCRG
YLVRQQIQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAIVTIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRRK--------------------------
-----------------------------------AKGPLVIPVKEQESENVLPSKKR-K
SIYDTVT--DTEMVEKVFGFLPSMIGGQEGQAPTGFEDLEVKTQ-KKLPEIDLDTVPMLK
E---PEEDVDGLAEYTFPKFAVTYFQKSATHTHIQRPLRYPLLYHEDDTDYSAALAVWNI
ILRFMGDLPEPMLYAKNSLSGS-PVMQQIHNTLDKENGPRGLQHGS--------------
---------------------AQVA----SQL-NIGEEPFDLDGPISE-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSG-NSRKSSTARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPAGYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LVTGESLAV---MVDSASTSREI--CQHIAQKKGLRDYLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAQEKGASQR-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--LRGRAVQELLPGCVPSKL
YKTKPPEKWASLVTDAHTK-APYTQTRATTL-------------------------AVQ-
EQVVDT---AL-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQR-E--RKLLELSFPEIMG---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AKGGQRLLLSTLH-EEYEFVSPSCVAIAEL
VALFLEGLKERSVFAMALQDRKATD----DVTLL-PFKKGDLIILTKKQALLVSE-SWTL
GQNDRTGKTGLVPTACLYTIPTLSKPSSQLLSLLAMSPEKRKLAAQEKQSSEPLPEEQ-P
KEKLHTLEDFSYE-FFRTPEKETVSRAMMPLARTRGHLWAYSLEPLRQPLLKRV----HD
RADL-------RDAACQIFQDILPQ-----PPYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSLPLQDS
ALQDEVYCQILKQL-TQNSNRYSEERGWQLLWLCTGLFPPGKALLPHAQKFLDTRRKK-L
LAPDCSRHIQKVLRTGPRKQPPHQVEVEAAEQNVSRLCHKIYFPNDTNE--MLEVGANTR
VRDVCESIATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLRHMSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWINVAPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDRSQLASIPKILRELVPENLTRLMSSEEWKKS-LLVECDKHKDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIVLIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKISN
WSSGSTYFHMALGSLGRGTRLLCETSLGYKMDDLLTS-----YVQQLLSAVNKQRGPRAP
SLAST----------------------------------

----------------------MSVFRLGDHVWLDPPSSTKSGVAMGGIVKET-KLGKTL
IEDDEGKEHWIRAEDLSSLRPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTTRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLGLGM
PSEYHYLTMGSCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNMRWAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALRPMSIISLLDEES
RFPQ--GTDVTMLQKLNSIH----ANNKSFLSPRSIHD--TRFGIAHFAGDVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQAK--ARSQI-----
----LKS-SDSTKRPVTLASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRMLLPSPERM-QFQNKPRQMTLRIADL
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIHRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAIRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAAWRGYSQRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILVGFERLQAIARSHLLMRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVIIQAHARGMVVRKS

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YWQQK--------------------------
-----------------------------------STGPEIILAKEPKAQGAVHERKR-K
SIYDTVT--DTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLHEVDLDTVPMMA
M---PEEEMDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALTIWII
ILRFMGDLPEPVVYGRSSLTGG-SVMRQIHDRLGKDSVTQGSQHNRS-------------
---------------------SKVA----SQL-NLGDEAFKFDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFIRQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGKSLTI---SVDSASTSREI--CQHVSQKQGLRDNLGFSL-----QVAVYDKFWSL-
GSGSDHVMDAVAQCEQLARERGESQR-----QAPWRIYFRKE--F-FTPWHDSREDPVST
ELIYHQVLRGVWS-GEYNFEKEEELVELLARHCYVQLGAT--VKSNAVQELLPSCVPSKL
YRTKSPEKWVSLVTAAHAK-AQYTQSKATPL-------------------------EVK-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPFR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------SPLD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGKKLLLSTLH-EEYEFISPSSVAIAEM
VALFLGGLKERSVFAMALQDRRATD----DVTLL-PFKKGDLLILTKKQGLLASE-NWAL
GQNDRTGKTGLVPTACLYTIPSVTKPSAQLLSLLAMSPEKRKLAAREVSAPEPPLEEQ-L
TESPYTLEEFSYQ-FFRAPEKETINRAMMPLARSRGHLWAYSPEPLRQPLLKSV----HD
KAKL-------RDAACQIFLDIL--------PTNLP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------MVVLRKGDHVWLDTQPKSEFNVPIGAVVKES-HSGRIL
LEDDEGKEHWITARNMHMVHLMHPSSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLHEAGMVHNLLIRHQEHKIYTY
TGSILVAVNPYQLLPLYTVDQIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTESTKLILQFLAAVSGQHSWIEQQILE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNQNGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNTEQKKMLNLGT
ASEYTYLTMGNCMSCDSRNDAKDYAHIRSAMKILMFSDSEHWDISKLLAAILHLGNVEFQ
AAVYDNLDCSDVIDSPHFSIATKLLEVDSSELQNSLTNLSIIVRGESVSRPLNVVQAANG
RDAFVKGIYGRIFLWIVNKINSAIFNPASQKPKDRHQSIGLLDIFGFENFSNNSFEQLCI
NIANEHLQQFFVHHVFKLEQEEYLAEHIAWNNIDFTDNHQALEVIALKPMNIISLIDEES
RFPK--GTDATMLVKINSLH----GKSKVYIPPKSVHD--TKFGINHFAGVVFYESKDFL
EKNRDT---LSANVMQVVHSSKNKFLREIFQVQM--------------------------
-----ANGLDTTKRLSTLGGQFKQSLEKLMKILEQCQPYFIRCIKPNDYKKPLLFDRELC
IKQLRYSGMMETIQIRKAGYPVRYSFEEFFERYRFLLPWAIDPCILKNDTRQSCISISEA
VLGKDESWQVGRTKIFLKDHHDTVLELQRQNILTDKVLLIQKVMRGLKD-RSQFLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--SAVAIQSAWRGYCCRKEF-RTVLLGFGRLQALYRSRQLAQQYETMRARIVAFQALCRG
FLLRQRLAEQK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 932)

KAACVIQAYARGMLARQTY-

ENSGT00900000140810_6_Linker_6_7 (932, 1259)

RRIKREYKSRVLSRLIFQSYKGKLTSTVG
WHSGS--A----------RKESQHSVRLFLCL-KEHLPT-QGREEAEARPRRNVLANK-P
ANHDVIS--DQEMVDKIFGFLPSVIGGQEGQAPLGFEDLETKP--NKLEEVDLDMVPMSV
ELEE---EALGLEDYTFPKFAATYFQGSSTHTHIRRQLRHPLLYHEDKDNVLASLAVWVI
ILRFMGDLPEPAMFAKSATTKSSSVMTQIYDTLGRKNQERKKTKISSLEHLSK-EGRRDN
KISKGISSLKLKRSSKL---TGKVT----EQL-RSGEEAFQEDISISQ-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1369)

SN
LEKVHFIIGNAILRPA--IRDEIYCQ-ICKQLTE-NSNRSSYARGWILLSLCLGCF--PP
SDTF-VKYLLNFIHHGPTGYAPYCAERLRRTYSNGARTEPPSWLELQGIEDQPPRSGHTS
IHSGTTG--QKQPPEESS----Y--YHF---WKELSNAYAFKMKGRREYDGAILSSTSF-
KCHPSHLSTDAHKAAPKSHQDKAHEK-----SINWHCYCCSR--DVIYIYESPCFDALK-
KLVIQTKIEKT---HFLNGPKEEDLVEIGAKYCYIQFGDT--IHNELVQKVLHDCIPVKQ
LKSKPLEKWVSLVTYAHAK-APYTQDHLSSQ-------------------------TVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNH----------------------------------------
-------------------------------------------------------FIIAI
NWKGICFLDES-E--KRLLELSFPEITGIH---------TNSWCKVILFRS---------
------------------------------------------------------------
Y----------------------------------------------------------K
KAPCEDCQNGSVRFS-DALVTNCSIIHRAVKSFGQSCTLITLRAEEFVLTSVNSVVIAEL
VVMFLEGLKKRSQFAVAMHEKKSQV-G-KDPGIL-SFKKGDLLIFTEGKRLDSDS-GWIC
AQNERTGKTGNVFLEDIYIIPSLTKPSSQVLSLLMMSPDQRRTASQNSFMEEPD-EED-I
KVKPYTLEEFSYE-HFRTPEKESISKAVLQKSRGHSQLWAHSKEPLKQPLLKRA----CT
DPDL-------RDLAS----H--SP----IMKFMGDYPSKQAHS

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2430)

SVEVTDQIFVPAIQEE
VLRDEIYCQIMKQL-TENRNRYSETKGWQLLWLCTGLFPPSKSLLKHAQKFIETRQK-ET
LAPGCRRRIQTVMRSGCRKWAPHPVEVEAILQNNTKISHKICFPNETEL--TFDVGTNTK
IQTLCQNIASKLELHSWEGFSLFVKIADK---VISQNEADYFFDSLRQVTDWNRRNKPGK
D----GAA-LSVAYEVYFMRKLWLNVTPGKDLKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

FHYHQELPKYLRGYHKCSKEEAV
QLAGLICKARFNNDRTQLAAIPKILKELVPDNLLRAVAPDEWKKS-IIAAYSKHEGKTVD
EAKIAFLKMIHRWPTFGSAFFEVKQASEPNFPEIVLIAINKQGVSLIHQKTK--------
-----------------------------------------------DILVVYPFNKISN
WSSGSTYFHMTIGNLVRGNRLLCETSLGYKMDDLLTS-----YVRLLMNAVNKQKN----
---------------------------------------

---------------------------QGEHVWLEASSSSQSKVPIGAVVKNS-HGTETL
VVDDDGKEHWISARNISSVHPMHPSLAHG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGELNEAGIVHNIHIRYKENNIYTY
TGSILVAVNPYQELPLYDTEQLEMYRNRRIGELPPHIFALGDTCFFNMQRTNTDQCCVIR
YKW-------IRKIIQFNAVPHNQRARAKWQVA--WHPPVIFAAFGNAKTIRNDNSSRFG
KYIEIHFSNKHVIEGARIEQFLLEKSRVCRQSPGERNYHIFYCMLLGMGSEQKKQLNLES
PSDYKYLTMGNCTNCDGRDDHKAFSQIRTAMKILLLSEIEQQEIFKMLAAILHLGNLKFK
AAMCGNLECCDVPESIHLSTVATLLEVDSAQLTNCLSNHTIIVRGESVSKPLSCTQASDS
RDAFVKGIYGRLFMWIVNKINKAIFTPDSE---NGRRSVGLLDIFGFEHFDTNSFEQLCI
NFANEHLQQFFVRHIFKLEQEEYNAEQIPWEHIDFSDNQRTLDVIALRPLNIISLIDEES
KFPQ--GAKLGFLHKSYWVHNKLLKADNIFQPSKNLLKCFFRFTVPHLAKYSFIIHTGFL
DKNRDL---LSTDIMLMIHTSSNYFLKQVFQMEVT-------------------------
------QTADTNRSLPTLGGQFKQSLEQLMKILESCQPYFIRCIKPNEFKKPKMFDRELC
IRQLQYSGMMETIRIRKAGYPIRYSFSEFFQRYRVLLPIQSPY-RKKENFREGCIDIAKS
VIGKHEDWKVGKTKLFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDNHDTKLEVERDKAI

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

TASAIRIQKVVRGYKD-RKRF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RE-
--AAIKIQSAWKSYYCRKTF-QKMLHGFQRLQAIIRSRPVQMQYKKKREVIIQLQGLSRG
YLLRKKIAKR

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KNAVLVLQTYTRGMLARKEY

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

RRMKRNEYPSQQDWEEAEKRKEMQKALLLQ
QEKENLEM----------VEQGS--RMVPVCKEMQKK-EMQKKENSRSAKRTERLVND-P
YNVKDYPFCSLQATGK-----SFTNSGEEGIAPNYFAQDMDTS--PFSDEIDLDTLLY--
-------EPDKEEEYTFPKFAATYFQGSATDTHIRKALQQPLLYHEDKNDVLASLAVWKI
ILRFMGELPEPALYTPNSSSERSSVLTQIYDTLTRKNNITAGIKDNFFQ---V-PKVNKK
GKGKEISSMKLKRASKL---AGQVS----RQL-SNGEEIMLEESSIID-------KP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKIHFIAGNGILRPE--IRDEIYCQ-ICKQLSG-NNNKTSVARGWILLALCLGCF--PP
SDKF-LRYLQNFIRTSQIAYNAICIKRLNRTLQNGVRSEPPSWLELQAIKGVGSFSVPVT
LMTGHSMNI---QTDSATNAREM--CKVIAQKLQLKDTFGFSV-----YISVYNKVWSL-
GFGSEHLMDGISQCEQLAKEQGEQER-----HSPWRLNFRKE--I-FTPWHDSSTDSVST
ELIYCQVIRGLCF-GEYRCDKEQELAELMLKHHYIKYGEV--LTDQHVESVMQDCVPPKQ
LETKQMSHWLSLLKERQAV-AQYVKEKHPAL-------------------------QVK-
EAFVEY---SR-----------------------------------------LQWPLLFS
KFFEASKFTEGPSI----------------------------------------------
----------------SRNH----------------------------------------
-------------------------------------------------------FIVAI
NWKEINFLDEK-E--KRLLQLSFPELIGIR---------TKSKAHNVAFQT---------
---------------------------N------------------------------SV
L----------------------------------------------------------Q
SLGLVLLEIPWAGWPPNLECAVYCLICRAEKTFGQCCILNTLRGEEFVLTSQHSDEIAHL
LLYFLDELKARSHYAVALQDSSHTV-K-DEPDLL-SFRSGDVLLLDRSPELQLRA-NWIF
AKNERTGKTGAVSLSSIHIIPTLSTPSSEILRLIVMSPEERKSEFYNALVEDF--EKQ-E
EVKPYTLEEFSLH-HFRNPDPESLSRAVLQRSRGKTHLWAYSREPLRQPLLRKV----CE
ISDL-------RDYACTAFT----A----IMKYMGDYPSKQT

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

HSPVELTDQIFSGPIKEE
ALRDEIYCQILKQM-TGNSKSYSVNSGWQLLWLCTGLFPPTKLLLVHVKKFIENRQK-EP
LAKASLRRILRVQQYGARKQPPHLVEVEAIQQMSTKIYHKVYFPNGKEE--TFEVGTNTK
VRELCQNISSKLQLTSWEGFSLFLKIGDK---VISQNEQDYFYDSLRQLNDFIRKTRPTA
DMAVAGTP-AFASFQLYFMRKLWINVQPGKDIKADCIFHYHQEVPKYMRGYNLCSVEDAV
NLAGLMYKVQYNNDRTHLATLNKNVRDLVPEYLLRLSTPEEWKKN-IIAAYNKHEAKTVD
EAKVAFLRQICRWPTFGSAFFEVKQSSEPSYPDIVLIAINKHGVSLFHPKTK--------
-----------------------------------------------ELLITHPFNKISR
WNSGNTYFQMTTGSLVRDNKILCETSLGYKMDDLLTS-----YIHYIMSKHQK-------
---------------------------------------

----------------------MSGLRLGDHVWLNPTPADKTRVAIGGIIKET-KPGKIL
VEDDEGKEHWIQAEDLGTLSSMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTVEQVQLYYKRHVGELPPHIFAIANSCYFNMKKSKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNSSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEEKKLLGLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILMFSDSENWDLSKLLATILHLGNVEFM
AAVFENLDSCDVMETPAFPTVMKLLEVKDQALRDCLTKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKHVQRTIGLLDIFGFENFQKNSFEQLCI
NLANEHLQQLFVRHVFTVEQEEYRAESIAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDATLLQKLKSVH----ANNKDFLQPKNIHD--AQFGIAHFAGEVHYHVEGFL
EKNRDV---LNRDILALVHSSQNKFLREIFGLESKESRRGPGTIVRVKAGS--QQ-----
----FKS-ADSSKQPSTLAGQFKQSLDQLMKILTNCQPYFVRCIKPNDYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYSFEEFSQRFRVLLPSAVRT-QLRNKFRQMTVCIAER
WLGTDKEWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KENQDTLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

EAAIRIQRVLRGYKH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAWWRGHYNQRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILLGFERLQAIARSHLLAKQYQALRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVKLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

RQQKATVP----------------------
--------------------------------------LV-IPEEEQKSPSAVPKRKR-K
SIYDTIT--DTEMVEQVFGFLPSLTGGQDGPATPHIEDPEEM--SQKLPEVDLDTVPTME
E---PEDD---LAKYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPVLFTRSILHGG-SVMGQIHDALGKDSSSQPPQHSRSA--QKLSRRDR--
-GTKDISSMKLKRSSWV---TGQVA----SQL-NIGEEAFEEDSPLSD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVQFVVGYAILRPS--LRDEIYCQ-ICKQLSE-NYKTSSLAR------ACLGCF--PP
SERF-LKYLLNFIGQGPVGYGPFCAERLRRTCANGVRAEPPSWLELQAVKSKKHIPIHIS
LATGESLTV---MVDSASTSREV--CLHIANKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDALAQCEQLARERGESER-----QAPWRLYFRKE--F-FTPWHDSQEDPVST
HLIYRQILHGVWL-GEYPFEKEDELVELLAQHCYVQLGAS--AGSQAIRELLPSCVPSKL
YRTKTPEKWASLVTTTYAK-APYTQKQARPL-------------------------TVQ-
EQVVDT---AC-----------------------------------------LKWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQK-E--KVLLELSFLEVMS---------LITNREAR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLTLCTLHEEEYEFRSPSSVAIAEL
VAMFLEGLKERSVFAMALQDRKATEDS----TLL-PFKKGDLLILTKKQGLLASE-NWTL
AQNDRTEKTGLVPTSCLYAIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEAPPEEQ-P
EENLHTLEEFSYEF-FRIPEKETVSRAVLPLARMRQPLLRRVHANAELRD----------
-------------AACQ-I-F--ID----ILSYMGDYPSRQAWT

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2430)

SLELTDQIFSSALQEA
ILQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-V
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRVCHKVHLPNDTSE--MLEVGANTR
VRDACDSIAARPQLAPRAGRRPSLHL-PQ---VISQKEGDYFFDSLRHVSDWVKKNKPQK
E----GAP-VTIPYQVYFMRKLWLNVAPGKDVKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKARFGDDRPQPASIPKILRELVPENLTRLMSLEEWKKN-ILLACNKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAS
WSSGSTYFHMVLGGLGRGSRLLCETSLGYKMDDLLTS-----YVQQLISTVNRQRGPRGS
VSSYL----------------------------------

-----------------MQVGRKATLGAGDHVWLDPPSTSQTGVAIGAIVKET-KPGKVL
IEDDEGKEHWIRTEDLSTLRAMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLVRYKQHKIYTY
TGSILVAVNPFQMLPLYTVEQVQIYYSRHMGELPPHVFAVANSCYFSMKKNKKDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSPEEKKMLGLGM
PSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILHFSDSENWDISKMLAAILHLGNVGFM
AAVFENLDSSDVMETPAFSFAMKLLEVQYQALRDCLVKHTIPVRGEYVSRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAVIFTPAAQDPQSVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVRHVFTMEQEEYLSENITWDYIRYTDNQPILDLLALKPMSIVSLLDEES
RFPQ--GTDVTMLQKLSSVH----ANHKSFLRPKNIHD--TRFGIVHFAGDVYYQVEGFL
EKNRDM---LSTDILNLVHSSKNKFLKEVFNLDSPQTKLGQGTIRQLNAGS--QF-----
----FKV-GSSP---------------HRMRVEVGCRPEEIFCLL-----SPQLFDRELC
IRQLRYSGMMETVQIRKSGFPIRYTFDEFSKRFRMLLPSSERK-QFQDKHRQMTLRIVDR
CLGTDKDWKMGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTTMEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVCIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RQ-
--AAVTVQAAWRGHYQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 889)

F-ELILVGFKRLQAIARSHQLVRQFQTMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVTIQAHARGMAARRK

ENSGT00900000140810_6_Linker_6_7 (930, 1307)

LCKQK--------------------------
-----------------------------------STGPPVIMPDKPKDRGAAPDRKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLPEIDLDTVPMTE
M---PE-DVDGLAEYTFPKFAATYFQKSASHTHVQKLLRYPLLHHENNTDHSAALAVWPI
ILRFMGDLPEPVLYAGSS-----SLTPQNHDRLGKGSDTRDPQHNGY-------------
---------------------AQVA----RKL-NAGEEVFKPDVPVSE-------RPMSN
LEKVHFIVGYAIMRPG--LRSVSLLA-SAQRFR---PLRWHLAHGG

PF00784 // ENSGT00900000140810_6_Domain_7 (1307, 1368)

IILSVCLECL--PL
PTIFHHQYLLNFLGQGPASYGPFCAERLQRTFSNGVRAEPPTWLELQAVKSKKHIPIQVV
LATGGSLTV---SVDSASTSGEI--CQHIAQKQGLRDRLGFSL-----QIAAYDKVSTG-
SLGLH-M----PPIHTRARGRGEG-E-----EEPWVHICRSSPRV-GPHWHPSRPC----
--------------HRRHCTQEEELVALLARHCYVQLGAS--VKSDAVRELLPSCVPSKL
YRTKPPEKWASIVTAAHAK-APYTQSKAAPL-------------------------AVK-
EQTVEA---AR-----------------------------------------VLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGMCFLDRK-E--RMLLELTFAEVMG---------LIANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRMLLSTLH-EEYEFLSPSSVAIAEL
VALFLGGLKERSVFAMALQDRKATD---

PF14604 // ENSGT00900000140810_6_Domain_10 (2129, 2177)

-DATLL-PFKKGDLLILTKKQGLLASE-NWVL
GQNDRTGKTGLVPTAY

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYIIPSLTKPSAQLLSLLAMSPEKRKLATQEVRAAEPLLEEQ-S
SESPYTLEEFSYQ-YFRAPDKETISMATMPMARSRGHLWAYSPEPLRQPLLRSV----HE
KAKL-------RDMACQIFLDIL--------P-TSDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLAQQDP
ALQDELYCQILKQL-THNSIRYSEERAWQLLWLCTGLFPPSKTLLPHAQKFIDSRKKK-P
LAPDCSRRLHRVLRMGPRKQPPHHTEVKAAEQNASKLCHEVYLPNDTSE--TMEVNSSSR
VRDLCEGIATRLKLASLDGCSLFINIIGK---VISLKEGEFFFDSLRQVSDWVKKNRPQK
E----GAP-ITLPYQVLFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKVQFGIDQSQLANVSKILKDLVPQNLTRLMSSEEWKKN-LLLECDKHKNKTTA
EAKVEFLKWISRWPTFGSAFFEVKQTSEPSYPDILLIAINRRGLLLIHPKTK--------
-----------------------------------------------ELLNTYPFTKISS
WSSGSTYFHMALGSLGQGSRLLCETSLGYKMDELLTS-----YVQQLMNAVNRQRGFAAP
ANP------------------------------------

----------------------MSGLRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDFGALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSENWDLSKLLAAILHLGNVGFI
ASVFENLDSSDLMETPAFPTVMKLLEVQYQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTLPAQDPKNMRRAIGLLDIFGFENFKNNSFEQLCI
NFANEHLQQLFVQHVFTMEQEEYRSENISWDYIHYTDNRPILDLLALKPMSIISLLDEES
RFPK--GTDLTMLQKLNSVH----TNNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSTKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFQEFSQRFGVLLPSALRM-QLRDKFRQMTLGITDK
WLQTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDQQDTLLEVQRSQLLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILVGFERLQAMVRSQLLARQYQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RKAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ASVPLVIPAEAQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPHLEDLESTTE--KLPEVDLDAIPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPLLYARNSQQGG-SVMHHIHDTLGRGHGAQALQHGGSAQ-----------
-----------------------VA----SQL-SIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPR--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERL-TKYLLNFISQGPATYGPFCAERLRRTYANGVRVEPPTWLELQAVKSKKHIPIQVT
LATGESLTV---PVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQEKGESHR-----QSPWRIYFRKE--F-FTPWHNSREDPVST
ELIYRQVIHGVWS-GEYSLEKEEELVELLAQHCYVQLGAS--AESKAVQELLPSCVPHKL
YRTKPPDRWASLVTAACAK-APYTQKQATTL-------------------------AVR-
EQVVDA---AL-----------------------------------------LQWPLLFS
RLFEVITLS-GSRL----------------------------------------------
----------------PRTK----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFTMAL

PF07653 // ENSGT00900000140810_6_Domain_10 (2119, 2177)

QDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-KWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQPAELQTKEP-P
KEKPHTLEEFSYE-FFRAPEKETGSRAVLPLSRARGHLWAYSSEPLRQPLLKQV----HA
NIDL-------WDVTCQIFVAIL--------RYMGDYPSRQARPTV

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHE
ALRDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQSVSRICHKIFFPNDTSE--MLEVGANTR
VRDVCDSIATRLQLASWEGCSLFIKITDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNDRSQLASVPKILRELVPENLTRLMSLEEWKKS-IPLAYDKHKDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRRGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQRLLSAMDKQRGSKAPALAST
---------------------------------------

----------------------MSALRLGDHVWLNPTSAHQTDVAIGGVIKGT-KPGKVL
VEDDEGKEHWVPAEDGVALSPMHPNLAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGELHEASMLHNLLIRYREHKIYTY
TGSILVAVNPFQALPLYTLEQVHLYYNRHVGELPPHVFAIADSCYFSMRKNKQDQCCIIR
NNDGAGLWATIHQLSMFLAYSCSQYSFYNSFLFL---PPPLLPAFGNAKTIRNDNSSRFG
KYIDIYFSPSGVIEGARIEQFLLEKSRVCRQAPGERNYHIFYCMLMGMSPEEKRLLGLGT
PSEYHYLATGDGTSCEGRHDAQDYAHVRSAMKILLFSDAENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDLRETPAFPVILELLEVQHQALRACLVKHSIVIRGELVTRPLTLAQAADR
RDALVKGIYGHLFLWVVGKILWGEGVAVVEAEKGRPR--GPGVVRGHPQAPPHSFEQLCI
NLANEHLQQFFVQHVFSLEQEEYRSEDIAWDHIHYADNRPTLDLLSLRPLSVISLLDEES
RFPQ--GTDATXPDTFNSLT----PNS-ILQASRSQID--CAFGVVKFFGFSSYINTSFL
EKNRDV---QSTDILALVHASKNKFLREVFKLESAEIRLGHGTVRRAKAGS--QL-----
----FQS-ADSAKQPSTLAGQFKQSLDQLMKILASCQPYFIRCIKPNEYKKPLLFDRALC
LRQLRYSGMLETVQIRRSGFPVRYTFEEFSQRFRVLLPGAERR-QLQGKFRQMTLQIADT
WLGTNKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDQQDTRLETERSQAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 834)

EKAAVNVQRALRCYRH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQSWWRGYCTRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

RLILLGFERLQAIARGRLLERQYQAT

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 906)

RRSVVRLQAVCRG
YLARR

ENSGT00900000140810_6_Linker_5_6 (906, 911)

EAESR

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 929)

RRAVLVIQAHARGMAARRSARRRR--------------------------
-----------------------------------ASAPLVIPAGQREGRSASPAQKR-R
SIYDTVT--DTEMVEQVFGFLPSMIGGQEGPAPPRFEGSCDRAH--RLPAGAC--VPAGR
A---QGVCSRGAGGHRWARHPTEGVQAQALASRSPGSTRVHGVPREVAASCQPGLSRGGF
VERRRE-------------AGP---------------GGLCRRHGGCRSTSPPRTGHSLP
GGQKDA---------RPPPPWRGFA----EVF-TPLHPCFSWEGPASG-------SESRS
ILKLWLCLAVAELHPR--KVAPISVFLRCV--ST-K---RAVLYIYTRIFFSTVCWA-AS
SPSLAHQYLLNFIGHGPVGYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPVHVV
LGTGQSLTV---MVDSASTSLEV--CLHIARTRGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLARERGEGER-----QAPWRIYFRKE--F-FTPWHDSREDAVST
ELIYRQVLHGVRS-GEYSFEKEEKLVELLARHCYVQLGAS--AGREAVQELLPACVPAKL
HRTKPPERWASLVTAALAQ-APYVQARTPPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFQVTTLS-GPRL----------------------------------------------
----------------PKAQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVTS---------LITNRA-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ARDGQRLELSTLHEEEYKFMAPSSVAVAEL
VGLFLEGLKERSVFAMALEDRRATD----DTALL-PFKKGDLLILTEKQGPPASE-SWTL
AQNERIGRTGLVPTACLFIIPTISKPSPQLLSLLAMSPEKRKLAAQEGHPAEPPPVEE-P
KETPHTLEEFSYE-FFRAPEKETVSRAVFSLARPRGHLWAHSPEPLRQPLLKRV----HA
SAEL-------WDCT--YQISIAAP----ILRYMGDYPSRQAWSS

PF00784 // ENSGT00900000140810_6_Domain_12 (2326, 2430)

LQLTDQVFTPAVQDA
ALRDEVYCQILRQL-THNHHRYSEERGWQLLWLCTGLFAPGKALLPHAQRFLDTRRKT-Q
LAPDCSRRLQRVLRVGPRTQPPHQVEVEAAEQNVARICHRVYFPNDTSE--MLEVGASTR
VRDLCQAIATRLQLASWEGCNLFVKIADK---VISQKEGDFFFDSLRQVSDWMRKNKPQK
E----GEG-GFWAGAGRVVRAMGIEVGEGGGVGWGG------------------------
--GGEVWGG------------------VG-------GESMGWGRGGESMGWGEKREHGVE
VG--------------------------------------------------------GG
ERMGWKQERIGWD----------------------------------GIGWEHPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTVHRQRGTRAP
PEP------------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAVANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDLTKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMRLLEVQHQELQDCLIKHTILIRGEFVTRPLNVAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFKNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYHSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ASNKAFLQPKDIHS--ARFGIAHFAGEVYYQAEGFL
EKNRDM---LSTDILTLVYSSKNKFLREIFNLELAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAVRM-QLQGKFRQMTLGITDM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQTK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ASAPLVIPAEGQKSQGALPAKKR-R
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSSQQGS-SVMQQIHDTLGREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NTGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPANYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREM--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQRQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KMLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAITEL
VALFLEGLKERSVFAMALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKMGLVPTACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFSEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDIVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIACQIFVAIL--------RYMGNYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPVCSRRIQRVLRTGPRKQPPHQVEVEAVEQNVSRICHKIYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKSKPQK
E----GAP-VTLPYQVYFMRKLWLNISPGKDVNADTILHYHQ------------------
--------------------------------------------S-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTLNKQRGSKAP
ALAST----------------------------------

--------------------VSVFGELIGDHVWLDPPSTDKSNVAIGGIIKET-KPGKIL
VEDDEGKEHWIQAEDLGALSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQLLPLYTLEQVQLYYGRHVGELPPHVFAIANTCYFNLRKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVHNDNSSRFG
KYIDIYINPSGVIEGARIEQFLLEKSRVCHQALEERNYHIFYCMLMGMSEAEKKLLDLGT
PSEYHYLTMGNCTTVKGLNDTMDYAHIRSAMKILLFSDSENWDISKLLAAILHLGNIEFM
AAIFENLDSSEVMETPTFPIVVKLLEVEHQPLRDCLIKHTILIRGEYVTRPLNIGQASDR
RDAFVKGIYGHLFLWIVKKINAVVFTPPAQDPKIVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYRSENLTWDYIHYTNNQPTLDLLALKPMSVISLLDEES
RFPK--GTDLTMLQKLNNVH----TNNKAFLKPKSIHD--ARFGIAHFAGEVYYQTKGFL
EKNRDV---LSTDILTLVHSSKNKFLRQIFNLESAETKLGHGTIRQAKTGS--QL-----
----FKQSTDSAKQSPTLAGQFKQSLEQLMKILTRCQPCFVRCIKPNEYKKPLLFNRELC
LRQLRYSGMMETVRIRKSGFPVRYTFEEFTQRFWVLLPTTQRT-QV-YNFRQMTLSIADL
CVESDKAWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEIQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAVRIQRVLRGYKH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLRQKQ-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVTLQARWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KMILVGFERLQAIAQSHILARQFQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQARCRG
YLVRKQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHTRGMAARRCF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRQK--------------------------
-----------------------------------ASGPVIIPAEEQKNQSALPTKKRSK
SIYDTVT--DTEMVEKVFGFLPSMLGGQEGQAPARFEDLETKTP--KLPEIDLDTVPMVE
E---PKEDMDDLAEYSFHKFAVTYFQKSASHTHIRRLLRYPLLYHDDNTDYSAALAVWTI
ILRFMGDLPEPVLYAKNSLRGS-PVMPQIHDRLGQEGMAQGAQHTGPVQ-----------
-----------------------VA----SQL-GTGEEAFNPDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NPKVSSQARGWILLSLCLGCF--PP
SERF-LKFLLNFIGQGPAGYGPFCAERLRRTCANGVRTEPPTWLELQAVKSKKHIPIQVI
LVTGQNLTV---TVDSASTSWEV--CLHIAQQQDLIDHLGFSL-----QVAVYDKFWSL-
GSGKDHVMDAVARCEQLTQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQILHGVWS-GEYSFEREEDLVELLARHCHVQLGAS--SGTEAVRDLLPSCIPPKL
YKTKPPEKWASLVTAAQAK-ALYTQTGATAL-------------------------AVR-
QQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGLHFLDQR-G--RMLLELFFPEVTS---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------SRGGQRLLLSTLHAEEYEFTTPSSVAVAEL
VALFLEGLKERSVFAMALQDRKTTD----DVTLL-PFKKGDLLVLTKKQGLLVSE-NWAL
GQNDRTGKTGLVPMACLYTIPTVIKPSSQLLSLLAMSPERRKLAAQEGLPSDLLPEEQ-P
REKPHTLEEFSY-KFFRAPEKETVSRAMMPLARTRGHLWSYSMEPLRQPLLKHV----HD
KADL-------RDVA---FAPIL--------KYTGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSLALQEP
SLQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRKK-L
LALDCSRRIQRVLRTGPRKQPPHQVEVEAAEKNVSRVCHKIYFPNDTSE--MLEVGTNKR
VREVCELIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GTL-VTLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFYKCSREDAI
HLAGLIYKAQFDNDRSQLASVPKILRDLVPENLTRLMSSEEWRKS-LLLEFDKHQDKTVQ
EAKVDFLKWICRWPTFGSAFFEVKQASEPSYPDIVLVAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMVRGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSVVNKHRGSRAA
PLATP----------------------------------

----------------------MLAFRLGDHVWLDPPSTGKSSVAIGGIIRET-KPGKVL
VEDDEGKEHWIQADDVGALSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQLLPLYTLEQVQLYYGRQVGELPPHVFAIANTCYFNLRKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIHNDNSSRFG
KYIDIYINPSGVIEGARIEQFLLEKSRVCHQALEERNYHIFYCMLMGMSETEKKLLDLGT
PSEYHYLTMGNCTACEGLNDAKDYAHIRSAMKILLFSDSENWDISKLLAAILHLGNIEFM
AAIFENLDSSEVMETPAFPIVMKLLEVHHQPLRDCLIKHTILIRGEYVTRPLNIGQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFAMEQEEYCSESLAWDYIHYTDNQPTLDLLALKPMSIISLLDEES
HFPK--GTDLTMLQKLNNVH----ANNKAFLKPKNIHD--ARFGIAHFAGEVYYQAKGFL
EKNRDV---LSTDILTLVHSSKNKFLREIFNLESAETKRGHGTIRQMKMGS--QL-----
----FKS-ADSARRPSTLAGQFKQSLEQLMKILTRCQPCFVRCLKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPVRYTFEEFAQRFWVLLPSSQRT-QLRDNFRQMTLSITDL
CLESDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTLLEIQRGQALEG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVHIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLRQKQ-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVTLQAGWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KMILVGFERLQAITQSRVLARQFQAIRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVVIQAHARGMAARRR

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YLQQQKASVSAHP------------------
---------------------------------AFEQGPVVIPAEEQKNQSALPTKKRSK
SIYDTVT--DTEMVEKVFGFLPSMIGGQEGQAPVRFEDLETKTP--KLPEIDLDTVPTTE
D---LQEDTDGLADYTFHKFAVTYFQKSANHTHIRGPLRYPLLYHDDNTDYSAALAVWTI
ILRFMGDLPEPVLYAKNSLQGS-PVMRQIHNRLGQEGTAQGAQHPGSVQ-----RRSRRE
RGTKDISSMKLKRSSWV---TGQVA----SQL-STGEEAFDPDGPVSD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGCAILRPG--LRDEIYCQ-ICKQLSE-NPKASSQARGWILLSLCLGCC--PP
SERF-LKYLLNFIRQGPAGYGPFCAERLRRTCANGARMEPPTWLELQAVKSKKHIPVQVT
LVTGQSLTV---TMDSASTSREV--CLHIAQQQDLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVARCEQLAQERGESQS-----QSPWRIYFRKE--F-FTPWHDSREDPIST
KLIYRQVLHGVWS-GEYSFEKEEELVELLARHCHVQLGAS--SGTKAVQDLLPGCIPPKL
YRTKAPEKWAGLVTAAQAK-ASYTQTGASAL-------------------------AVR-
QQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLHFLDQR-G--RMLLELSFPEVTS---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AWGGQRLLLSTLHAEEYEFTTSGSVAVAEL
VALFLEGLKERSVFAMALQDRKATD----DVTLL-PFKKGDLLVLTKKQGLLASE-NWAL
CQNDRTGKTGLVPMACLYTVPTVVKPSGQLLSLLAMSPEKRKLAAHEGQPSEPLPEEQ-P
REEPHTLEEFSY-EFFRAPEKETVSRAMMTLARTRGHLWSYSMEPLRQPLLKRV----HD
KADL-------RDFACQIFLAIL--------KYTGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSWALQEP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRKK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEKNVSRIRHKIYFPNDTSE--MLEVGTNSR
VREVCETIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GTP-VALPYQVYFMRKLWLSVVPGKDLNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNDRSQLASVPKILRDLVPENLTRLLSSEEWRKS-LLLEFDKHQDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQASEPSYPDIVVVAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSVVNKQRGSRAA
P--------------------------------------

------------------------------------------------------------
----------------------------------------------------------

PF00063 // ENSGT00900000140810_6_Domain_0 (119, 798)

TY
VGAILVAVNPYQVLPIYTMDQIQLYYNRKIGELPPHVFAIADSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLAIISGQHSSIEQQVLE---ANPILEXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXGTDATMLQKMNHLH----SNSKVYVAPKNTHD--MKFGIVHFAGLVHYQAEXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXXXXXXXXXXX
XXXXXXXNADATKRPSTLASQFKQSLDQLMKILNNCQPHFIRCIKPNEFKKPMLFDRQLC
IQQLHYSRMLETVKIKEISYSIRYTFEDFFQRYKILLPXXXXX-XLQDKPRQATLRISEN
WVGKDENWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDYQDIQLEVQRSQVL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

NKNAVIVQKAIRGYKY-RKEF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LSQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

KR-
--AAVTLQAAWRGHACRRNY-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KMILLGFERLQAFVRRHQLTKQYKAT

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RAKVIQFQALCRG
YLIRQKV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

AEK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KRAVVVIQAHARGMIARQNFNRRKIEERLA--------------------
--------------------------------------VL--EGENRKNQMDQPTKKR-A
SIYDPVN--DTEMVEKVFGFLPIIIGGQKGQAPQGFEDLETTT--QKLTEVDLDTIPMSV
EPEE---DMDDLDEYTFPKFAATYFQKAATHTHIRRPLHHPLLYHEEDEDFQIALVIWKI
ILRFMGEFPEPQLFAKSSNPQGTLVTRQIRDSLGKKNNARFLTDSKTEK-----------
-----------------------VA----KKL-SSGEEAFKEESPITE-------RPMSN
LEKVHFIIRNGIQQPNIXXXXXXXXX-XXXXXXX---XXXXXXXXXXXXXXXXXXX--XX
XXXX-XX

PF00784 // ENSGT00900000140810_6_Domain_7 (1328, 1370)

YLLNFISKGPSGYRSFCTEQLRRTYANGVRTEPPNSLELQAVKSKARIPVNVT
LMNGESLTI---AADSASSSREV--CQHIADKLRLKDLFGFSI-----YVAIYDKXXXXX
XXXXXXXXXXXXXXXXXXXXXXX--X-----XXXXXXXXXXX--XXXXXXXXXXXXXXST
ELIYHQIIRGFRF-GEYRLEKXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-APYIQNLSSPL-------------------------SVK-
EQIVSE---VC-----------------------------------------FQWPLLFS
KLFEVTKISV--------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------FIKNM
SSHRAQSERDSGQIREETLGSDFP------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SYWHSHQQ-VSALRIHRAPQVFKQNFTLSTLNTEEYVFVSSESVAITEL
IAMFLEGLKKKSMYAMATRDKKS---T-DDPTIL-MYKKGDLLILTKDEGIAPND-NWIL
AHNDRTDKTGAVSIEDIYIIPTIVKPTPQMMSLAM--PEDRKLATQNAQTK---VEKE-L
KEKPYTLEEYSYE-YFRLPEKETINKAMFPKARGKSQLWEHSWEPLRQPLLKRV----HA
NVDL-------RDVACQTFA----P----ILKYMGDYPSKQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

RDPVELTDQIFAAAIQEA
TLRDEVYCQIMKQL-TKNTKSYSLERGWQLLWLCTGLFPPSKTLLPHTQKFIESRRKNQP
IAPDCSRRIQRVMRTGPRKWPPHQAEVEAIQQNIIKICHKVYFPNDTEE--IFEVGANTK
VQELCQNISTHLQLNSWEGCSLFVKISDK---VISQNEKDFFFDSLRQVSDWIRKTKPTK
E----GTT-APLYYHVYFMRKLWLNVSPGKDLKADTILHYHQELPKYLRGFHKCSREDAI
QLAGLIYKVQFDKDRSQLATVSRILKDLVPENLIHLMSSEEWKKN-IFAAYNKCEEKTVD
EAKVAFLKLIYRWPTFGSAFFEVKXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------
-----------------------------------------------XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXGYKMDDLLTS-----YVQLLLSAVNKQKNSRAL
DGG------------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEA-KPGKVL
VEDDEGKEHWIQAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVTKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRM-QLQGKFRQMTLGITDV
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

RQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-R
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQASPRFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQRSASHTHIRRLLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSSQQGS-SVMRQIHDTLGREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREM--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIAQCEQMAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLQGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQKQVTPL-------------------------AMR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GSRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQQ-E--KMLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALLLEGLKERSIFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DTTLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPMAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEP-P
KEKLHTLEEFSYE-FFRAPEKDMVSMAMLPLARARGHLWAYSCEPLRQPLLKR----VHT
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSE--MLEVVANTR
VQDVCDSIATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLREVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNISPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQRGSKAP
ALAST----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_1 (90, 180)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCII

ENSGT00900000140810_6_Linker_1_0 (180, 237)

S
LAT--------------------------------------------------SSE

PF00063 // ENSGT00900000140810_6_Domain_0 (237, 798)

HRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFEEFSQRFGALLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQALQH-RF-------------
---------------------AQVA----SQL-NIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAITQCEQLAQERGESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHRL
YRTKPPDRWTSLVTAACAK-APYTERQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLTMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIAST---PIL--------RYMGDYPSRQARPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQAEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNITPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSHLASVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------PTGSGGT-----------LPTHPLCPQDL
WSSGSTYFHMVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------FINRGPVSYGPFCAERLQRTCANGVRMEPPTWLELQAVKSKKHIPIQVI
LVTGQNLTV---MVDSASTSREV--CLHIAQKQDLTDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQVLHGVWS-GEYSFEKEEELIELLARHCHVQLGAS--SGSNAIQDLLPSCIPPKL
YKTKTPEKWTSLVTAAQAK-APYTKTGATAL-------------------------EVR-
QQVVDT---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGINFLDQR-E--RTVLELSFPEVTS---------LVTDRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AWGGQRLLLSTLHGEEYEFTTPSSVAITEL
VALFLEGLKERSVFAMALQDQKATD----DVTLL-PFKKGDLLVLTKKQGLLTSE-NWTL
AQNDRTGKTGLVPTACLYAIPTVVKPSAQLLVSHTLTSAQL---DTEG-TAS--------
--------FFRYLTTPEAPEKETISRAMMPLARTRGHLWSYSLEPLRQPLLKQV----HD
KADL-------RDIACQIFLDILPY----QLPYTGDYPSRQAWSTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSSALQEP
ALQDEVYCQILKQL-THNANRHSEERGWQLLWLCTGLFPPGKALLPHVQKFIDTRRRK-K
LASDCSRRIQVVLRTGPRKQPPHQVEVEATEKNISRICHKIYLPNDTSE--V--------
--KVCEAIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GAA-VTLPYQVYFMRKLWLNVVPGKDMNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDQSQLSSVPKILRDLVPENLTRLMSSEEWRKS-LLLECNKHRNKTVQ
EAKVAFLKYICRWPTFGSAFFEVKQASEPSYPDIVLIAINRHGVLLIHPKSK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLSS-----YVQQILNVVNRHRGSQAT
ALAVL----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------

PF00063 // ENSGT00900000140810_6_Domain_2 (729, 798)

MMETVKIRKAGYPIRYTFEDFFQRYKTLLPADAHV-QLKDKPREGARRISET
WLRKDKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_2_3 (798, 815)

KEQQDTLLEVQRRQALY

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KNAVIIQKVIRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLSQKR-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVTLQAMWRGYTCRKNY-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLIVLGFERLQAMFRGHQLSRQYKATRAQ

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 906)

VIQLQALCRG
YLIRR

ENSGT00900000140810_6_Linker_5_6 (906, 911)

KVAEK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHLRGMVARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

RRRKREERR---------------------
-------------------------------------PALETEGESRKKQAAPPPRKR-Q
SIYDPVS--DTEMVEQVFGFLPMIIGGQEGQAPQGFEDLESTPH--KLTEVDLDAVPMSE
E---PEEDAEDPDEYTFPKFAATYFQKAASHTHIRRPLRHPLLYLEEDEDFRIALLVWKI
ILRFMGEFSEPQLFAKNSSLQGTAVTRQIQDTLGKKNSAHFLKAGEPE-----QNSTWRN
KGTRDISSMKLKRSSRL---TGQVA----RKL-SSGEEAFEEESPVTE-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

TN
LEKVHFIIRNAIQRPN--IRDEIYCQ-ICKQLSE-NYNKSSFARGWILLCLCLGCF--PP
SEKF-MKYLLNFISKGPTGYRAFCSERLRRTYANGVRSEPPNSLELQAVKSKTRILFHVT
LMNGESLTL---TADSASSSREA--CQHIADKLHLKDLFGFSL-----YIAIYDKVTRL-
SLHVPPSL-------QRGIESGQGERDISGRARPMALSS-------LTLNDHTKQNPEER
TLRARLVEEMNFL-LPIERLQEEDLVEVVAKHCYIEFGSS--IQNSDIQKTLSTCIPGKV
LKTKPQGQWVSLVTAACAKVRTSRWHIGVIKKRKGKISHVNISGFIFSESFGLVRGDVQE
SSMVEV---QEFKYPNSFELEKRAISNLPLFTQQVRRNKVSYQLCPKISLILFSHPLPFS
RIENTILLH-KPNKKIDFSSMFFFFKPLPSILESVLLNVLFGTRSTDSMKRHRHFLSFHY
DFEHYRYDNSIKGFMWPPLWSFPSCNLQGRNTSAGHPRFFFSILGFLHTKSLLSTVGKGT
NCGYGLFSVASTIFQLIGKGNREENVGDGLRQGAIPQVFIKNIFLFPGPSLPKTELIVAI
NWKGLCFIDKS-E--KKLLDLSFPEITG---------IATNRS-----------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------VLKQNFILSTLKAEEYVFISSESVAIAEL
VAMFLEGLKKRSIYAMAMRDKKSTD----DPTVL-AHKKGDLLILIKSNGTVSSD-KWIP
AHNDRTDKTGEVSVESIYIIPTVMKPTPEMMTLLAMSPEDRKLAIQNAQPEEPAEE---P
KEKPYTLEEYSYE-HFRLAEKETLNKAMFPKGRGKSQLWEHSREPLRQPLLKRV----HA
NVDF-------RDIACQIFTDILFLLGQHLSQIPGDYPSKQARD

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2431)

PVELTDQIFLAPLEEA
TLRDEVYCQIMKQL-TSNRNSYSLERGWQLLWLCTGLFPPSKTLLPHTQKFIETRRKKQQ
LAPDCSRRIQRVMRISPRKHPPHHVEVEAIQQNITRICHKVYFPNDTNE--VFEVGTNTK
VQDLCQNISTHLQLNSWEGCSLFVKISDK---VISQKETDFFFDSLRQVSDWIRKTKPTK
E----GATTVTLTYHVYFMRKLWLNVFPGKDLNADVI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCTREDAI
QLAGLIYKVRFDNDRSQLATVSKILKDLVPENLIRSMSSEEWKKN-IFAAYSNSEKKTVD
EAKVAFLKMIYRWPTFGSAFFEVKQSSEPAYPDIILIAINKRGLQLIHPKTK--------
-----------------------------------------------EVLHTYPFSKISS
WSSGSTYFHLVLGNLMKGSRLLCETSLGYKMDDLLTS-----YVQLLMSAVSKQNSRTSD
---------------------------------------

----------------------MSAFQLGDHVWLDPPSANKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDLGALSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMICLGDLNEAGMVHNLLIRYRQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNHHVGELPPHIFAIANNCYFDMRRNKRDQSCVIS
GESGAGKTETTKLVLQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIDIYFNLSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMRAEDKELLCLGT
PSEYRYLTMGNCTSCEGLSDAKDYTHVCSAMKILQFSDSENWDLSKLLAAILHLGNVEFM
AVVFENLDSSDVMETPAFPAVTKLLEVQHQALRDCLIKHTILICGEYVTRPLNIAQAADR
RDAFAKGIYGHLFLWIVKKINTAIFTPLSQDPKNVRKAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSEGIAWDYIHYTDNRPTLDLLALQPVSIISLLDEES
RFPQ--GTDITMLQKLNRVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGS--QL-----
----FKS-ADSAKQPSTLAGQFKQSLDKLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVKIRKSGFPVRYSLEDFSHRFRVLLPSAAGM-QLRDKFRQMTIGIADM
WLGTDRDWKVGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KGYQDTLLEIQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAVSIQRVLRGYRH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILVGFERLQAIARGHLLARQYQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQE

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVLVIQAHARGVAARQSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRRK--------------------------
-----------------------------------ANALLVTPAAEKKSQSALPAKKR-K
SIYDTVT--DTEMVEEVFGFLPAMIGGQEGQAPPCFEDLEAKTR--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAATYFQKSASHTHIRQPLRYPLLYHEDDTDCSAALAVWNV
ILRFMGDLPEPVLYARSS-QGS-SVMQQIYDTLGRASGAQSLQQAGSA------------
----------------------QVA----SQL-NTGEEASEPSGPVTD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGCAILRPG--LRDEIYCQ-ICKQVSE-NFRPSSLARGWILLSLCLGCV--LP
SERF-MKYLLNFIGRGPAGYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
MVTGESLTV---TVDSASTSREI--CLHIARKQGLSDYLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
KLIYHQVLRGVWS-GEYSFEKEEGLVELLARHCYVQLGAS--VGDKAVRELLPGCIPPKL
YRTKPPEKWASLVTAAYAK-APYTQTQAAPL-------------------------AVQ-
EQVVDT---AY-----------------------------------------LQWPLLFS
RLFEVTTLS-GPCL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAV
NWKGLYFLDQQ-E--KMLLELSFPEIMC---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTLH-KDYEFLSPSSVAIAEL
VALFLEGLKERSVYAMALQDRKATD----DPTLL-PFKTGDLLVLTKKQGLLTSE-NWTL
AQNDRTGKTGLVPTACLYAIPTLTKPSAQLLSWLAVSPEKRRLAAQEGQPARPPAAEQ-P
WEEPHTLEEFAYE-FFRAPDKGTVSRAVLPLARTRGHLWAYSPEPLRQPLLKRV----HA
SADL-------RDIACRIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSLALQDS
SLQDEVYCQILKQL-THNSNRRSEDRGWQLLWLCTGLFPPSKALLPHAQKFIDTRRGK-L
LAPDCSRHVQRVLRMGPRKQPPHQVEVEAAEQNVSRICHRVYLPNSTSE--MLEVGSSTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQLYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNHWSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHRDKTVE
EAKVAFLTWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLATHPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTMDKPRGPRAP
ALASP----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------

PF00063 // ENSGT00900000140810_6_Domain_2 (598, 798)

GFL
EKNRDT---LGADILNLFHSSKNKFLKEIFHLDKS-------------------------
------PGSDATKRPSTLGGQFKQSLDQLMKILASCEPYFIRCIKPNEFKKPLLFDRELC
IRQLRYSGMMETVKIRKAGYPIRYTFEEFNKRYNFLLPGSS-ECQMQGDPRQNTLHISKV
LLGNDQDWKMGKTKIFLKSEHDTLLEIQRSKIIESKAILIQKVLRGYKC-SQHLTKLRLN
TWREALIQKIWEDSHWRVQH-NIILLGFERLQALIHSRQLAQRYKTTR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 906)

ANIIRFQALCRG
YLTRQ

ENSGT00900000140810_6_Linker_5_6 (906, 911)

KIARE

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 932)

RKAACVLQAHTRGMYARRNF-

ENSGT00900000140810_6_Linker_6_7 (932, 1311)

QRKKREYQLRADVREIHLASSESVFKQRN
---GQKLV----------EREERRNKESTNCIIVEKSLGILEKEVGDRKKQDPRSNKR-R
SIYDTIS--DTEMVEKVFGFLPKMIGGQEGEAPKGFEDLETPP--QKLDEVDLDTIPMSV
DLNE---EVDDLAEFTFPKFAATYFQKSATHTHIRRSLRYPLLYHEDDSEILASLAVWNV
ILRFMGEFPEPLLYAKNNSLKGSSVMTQICDTLGKKSNARFVSGRSLDQVMVP-KG----
-------PLALTQNEHF---SEDMHLPEENRM-QWQNKWLRHFCGISQSNTYYNNNKKKK
KKKGHSLIGDLLIFESTTCPDRFFRK-IDDPGTVLSSWESMIQQSW---Q

PF00784 // ENSGT00900000140810_6_Domain_7 (1311, 1370)

TCSQSH--LP
NSVS-TQYLLNFLSKGPSAYGPYCAERLKRTFTNGVRSEPPSWLELQAIKTKRPIVFSVT
LVNGQSITV---MADSASSSKET--CQYIAEKQKLKDQFGFSL-----YVAIFDKVQSS-
RPDSFPIPSHLEECLVTCLGQGGKSL-----KINNALFCPLS---LLPFWHPPSPLP---
-LYYSQLLLQVGI-EELRTSKEEGLVEIAARHCYVLFGHS--IKNEQVQKMLPDCIPAKL
LKTKPPEKWVSLITSAHAK-VSISRRQPES---------------------------FK-
TGVGPLHLIRT-----------------------------------------LDSPLSHP
RIYPDFYFR-RPDV----------------------------------------------
----------------APA-----------------------------------------
-------------------------------------------------------LLLSL
PISLLYSIGHSNT--LYLIPLSFQLVSSYYARFGRR-VFSNSQCLDRVDTK---------
---------------------------C------------------------------KL
A----------------------------------------------------------V
ITLFKMVHLLWTRWACN-----------GDSSLQVENSMDTLPERLQVEVGRSGRDVSVV
SLWVRDDLTAKDKENIQVSDHSTPA-P-LLPQFWSFLQKGDLLILNNDRKIVATK-DWMG
AENERTGKSGAVPLDAIYVIPTVLKPSPQMLSLLAVSPEERKLMRQNSHQEKPQ-EEE-S
QVQPFTLEEFAYE-FFRAPEKETISKAVLPKARGKSYLWAYTREPLKQPLLKKV----HA
IAEL-------RDPAYQAFI----D----ILSYMGDYPSSQAR

PF00784 // ENSGT00900000140810_6_Domain_12 (2324, 2431)

SPVELTDQIFTAAIYED
ALKDEIYCQILKQL-TENSNSYSVERGWQLLWLCTGLFPPSKSLLKPVQKFIDTRRK-KL
LAPECGRRIQKVMRVGPRKWPPHLMEVEAIQRNSTKFSHKIFFPNGTEE--TFEVGTNTK
VRDLCQNISSKLQLSSWDGCSLFVKISDK---VISQNEADFFFDSLRQVSDWTQKNKPVK
D----GAL-LNLPYTVHFMRKLWLNVTPGRDLNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSPDDAV
LLAGLIYKVKFDADNSQQATIPKMLKDLVPENLIRLMAAEEWKKN-IILAYNKYSGKTVN
EAKIAFLKYISHWPTFGSAFFEVKQTSEPNYPEIIQIAINKHGVLLIHPKSK--------
-----------------------------------------------ELLNTYPFNKISN
WSSGSTYFHMMIGNLVRGNRLLCETSL---------------------------------
---------------------------------------

----------------------MSVFRLGDHVWLDPPSTSKTTEAIGGIVKET-KPGKVL
IEDDEGKEHWIHTEDLSNLRAMHTNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLVRYKQHKIYXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXRHMGELPPHVFAIANSCYFSMKKNKKDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEDKKLLGLGM
PSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILHFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFSFAMKLLEVQHQALRDCLIKHTIPIRGEFVSRPLNIAQATDR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPQSVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQTILDLLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSVH----ANNKSFLKPKNIHD--TRFGIVHFAGEVYYQVEGFL
EKNRDT---LSTDILSLVHSSKNKFLKEIFNLESQQIKLGQGTIRQMKAGS-Q-H-----
----FKS-SDSTKRPLTLTGQFKQSLDQLMKILSQCQPYFIRCIKPNEYKKPLLFDRELC
IRQLRYSGMMETVQIRKSGFPIRYTFEEFSQRFRMLLPSPERK-QFQDKHRQMTLRIADR
CLEADKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RR-
--AAVTIQAAWKGHCQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 889)

F-ELILVGFKRLQAIARSHQLMRQFQTMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVVIIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQQK--------------------------
-----------------------------------TIGPQVILANEPKDQGAVPDRKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGPSPTRFEDLEVKTQ--KLPEIDLDTVPMME
M---PE-DLDGLAEYTFPKFAATYFQKSASHTHIQKLLRYPLLHHENNTDHMAALAVWPI
ILRFMGDLPEPVLHARNS-----SVMQQNHDRLGKDSGTQGPQHNGY-------------
---------------------AQVA----RKL-NIGEEAFKPDVPVSE-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAITRPG--LRDEVYCQ-ICKQLSE-NNKTSSLARGWILLSLCLGCF--PP
SGKF-MKYLLNFLGQGPGSYGPFCAERLQRTFTNGVRSEPPTWLELQAVKSKKHIPIQVV
LATGGSLTV---SVDSASTSREI--CQHIAQKQGLRDHLGFSL-----QIAVYDKFWSL-
GSDCDHVMDAVAQCEQLAQERGESQR-----QAPWRIYFRKE--F-FTPWHDSREDPVST
ELIYCQVLRGVWS-GEYNFEKEEELVGLLARHCYVQLGAT--VKSDAVRELLPSCVPSKL
YRTKSPEKWASIVTAAHAK-APYTQSKATPL-------------------------AVK-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGMYFLDQK-E--RTLLELSFTEVMG---------LIANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRMLLSTLH-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRKATD----DATLL-PFKKGDLLILTKKQGLSASE-NWVP
GQNDRTGKTGLVPMAYLYIIPSITKPSAQLLSLLAMSPEKRKLATQEVRAAEPLLEEQ-A
TESPYTLEEFSYQ-FFRAPDKETISRAAMPMARSRGHLWAYSPEPLRQPLLKCV----HE
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLAQQDT
ALQDELYCQILKQL-THNSIRYSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKK-P
LAPDCSRRLHRVLKMGPRKQPPHHVEVKAAEQNVSKLRHEVYLPNDTSE--TMEVNSSSR
VRDLCEGIATRLKLASLDGCSLFIKITDK---VISLKEGEFFFDSLRQVSDWVKKNRPQK
E----GAP-ITLPYQVFFMRKLWLNVTPGKDMNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDVI
HLAGLIYRVQFGCDQSQLASVSKILKELVPQNLTRLMSSEEWKKS-LLLECDKHKNKTVA
EAKVEFLKWICRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYTFTKISS
WSSGSTFFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQIMNAVNKQRGFRAP
ALANP----------------------------------

----------------------MPRFRLGDHVWLNSPSANKTDVAIGGVIRET-KPGKIL
VEDDEGKEHWIHSEDLGALSSMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLDEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQALPLYTLEQVQLYYSRLVGELPPHVFAIANSCYFNMQKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNNNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKKLLGLGT
PSEYRHLTMGNCTSCEGLDDAQDYAHIRSAMKILLFSDSENWDLSKLLAAVLHLGNLEFT
AAVFENLDSSDVMETPAFPIVMKLLEVQHQALRDCLIKHTILIRGEYVTRPLNSTQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPRNVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYRSENIAWDYIHYADNRPTLDLLVLKPLSVISLLDEES
RFPQ--GTDATLLQKLNSVH----TNNKAFLQSRNIHD--TRFGIAHFAGQVYYQAEGFL
EKNRDV---LSTDILTLVHSSKNKFLKEIFNLESAETKRGHGTIRQAKTGS--QL-----
----FKS-ADSAKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFPEFSQRFHVLLPSAVRL-QLRDKFRQMALDIANR
WLETDKDWKVGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEMQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAISIQRVLRGYRH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RW-
--AAVTLQAAWRGYGTRKNL-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILLGFERLQAIVRSQVLARQYQVMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKVVQLQARCRG
HLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRQK--------------------------
-----------------------------------ANALLVIPTKEQKNQSPLPAQKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPGFEDLEAKTQ--NLLEVDLDTVPMVE
Q---PEQDVDGLAEYTFPKFAATYFQKSASHTHIRQPLRHPLLYHEDDADCLAALAIWNI
ILRFMGDLSEPVLYARSR-QGS-SVVWQVQDTLGRGGGVQFPQQGGS-------------
---------------------AQVT----SQL-NSGEEAFEPDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRSG--LRDEVFCQ-ICKQLSG-NPKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPAGYGPFCAERLRRTCANGARTEPPTWLELQAVKSKKHIPIQVN
LATGEGLTV---TVDSASTSREV--CLHIARQQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
RLIYRQVLRGVWS-GEYSFEKEEELVELLARHCYVQLGAS--VGSQAVQELLPSCIPSKL
YRAKPPERWASLVTAAHAK-ASYTQTQATLL-------------------------TVQ-
EQVVDT---AH-----------------------------------------LQWPLLFS
RLFEVTPLS-GSRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KMLLELSFPEVMR---------LSTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTLH-EEYEFLSPSSMAVAEL
VALFLEGLKERSVFAMALQDRKATG----DATLL-PFKKGDLLVLTKKQELLASE-NWTL
AQSDRTGKTGLVPMACLHTIPTVTKPSAQLLVTHTLTCPPYRAQVPGAER---------P
RGKPSL-----HPPPVRTPEKETVGKAVLPLARTRSHLWAYSPEPLRQPLLKRV----HA
NVDL-------HDIACQIFVDILA-------QYMGDYPSRQAWPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2414)

ELTDQIFSLALQDS
SLQDEVYCQVLKQL-THNTNRYSEERGWQLLWLCTGLFPPSTSLLPHAQKFVDTRRGK-L
LAPDCSRRIQRVLRGRAGPGPPEWRVEGEAQEGLGRLT-----GHLSSQ--MLEVGSGTK
VRDVCDSVATRLQLASWEGCGLFIKIADK---VLSQKEGDFFFDSLRQASDWVKKNKPQK
E----GGG-GLCG--AGQARKRWLHCRVGKGAPV-----AT

PF00373 // ENSGT00900000140810_6_Domain_14 (2562, 2661)

QELPKYLRGFHKCSREDAV
HLAGLVYKAQFDGDRSQLAHVPKVLRELVPESLTRLMSAEEWKKS-ILLAYDKHKDTTVE
EAKVAFLKWISRWPTFGSAFFEVKQTSEPSYPDIILIAINRAGAALQE------------
------------------------------------GCLLPNPLSPQDLLTTHPFTKIAS
WSSGSTYFHMVLGTLGRGSRLLCETSLGYKMDDLLSS-----YVQHLLSTMNKQRGSRDP
TLVSP----------------------------------

----------------------LYYLQVGDHVWLETQTSSEFNVPIGAVVKDS-DSGRIL
LEDDEGKEHWIMAQNMHMVRPMHPSSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLHEAGMVHNLLIRHQQHKIYTY
TGSILVAVNPYQLLPLYTVDYIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTESTKLILQFLAAVSGQHSWIEQQILE---ANPILEAFGNAKTVRNDNSSRFG
KYIDIRFNRSGVIEGAQIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNLEQKKMLNLGT
ASEYTYLTMGNCTSCDGRNDAKEYAHIRSAMKILMFSDSEHWDISKLLAAILHLGNVEFE
AAVYDNLDCSDVMDSPHFSIATKLLEVDSSELQNSLTNLSIIVRGESVSRPLNVAQAADG
RDAFVKGIYGRIFLWIVNKINSAISNPTSEKPKNTHQSIGLLDIFGFENFSNNSFEQLCI
NIVNEHLQQFFVHHVFKLEQEEYLAEHIAWNNIEFPDNHQALEIIALKPMNIISLIDEES
KFPK--GTDATMLIKINSLH----GKSKVYIPPKSDHD--TKFGINHFAGAVFYESKGFL
EKNRDT---LSTNVMQVVHSSKNKFLRQIFQQYCV-------------------------
-----SKGLDTTKRVSTLGGQFKQSLEKLMKILGQCQPYFIRCIKPNDYKKPLLFDRELC
IKQLRYSGMMETIQIRKAGYPIRYTFEEFFDRYRVLLPWSVQQ-QLKNDARQCCIGISEA
VLGKDESWQAGETKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDHHDTVLELQRQKIL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

TDKVLLIQKVMRGFKD-RKQF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RK-
--SAVAIQAAWRGYCCRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

RMIMLGFGRLQALYRSRQLAKQYETT

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RARVIKFQAACRG
YLIRQKIGTWKKAVCLIQAQCKGRVCLPNF-AKDEERYKNRVLKEATRFEENSKTQSCKL
TCKDD-------------LEMGQVMLNQILCL-KKHLSTLEINEEEERQRRTDVFASR-P
ANDEVIS--DQEMVDKIFGFLPSMIGGQEGQAPLGFEDLETKP--HKLEEVDLDTIPMSV
ELEE---ETDGLEEYTFPKFAATYFQGSSTHTHIRRPLRHPLLYHDDKDNVLASLVVWVI
ILRFMGDLPEPAMFARNVT-KNSSVMTQIYDTLGRKNQVQFKSDS----PGMR-ESRKDN
KISKGISSLKLKRSSKL---TGKVT----DQL-RSGEEGFQEDTSISE-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVHFIIGNAILRPA--IRDEIYCQ-ICKQLSE-NSNRNSYARGWILLSLCLGCF--PP
SETF-LKYLLNFIHKGPSGYAPYCAERLRRTYVNGARTEPPSWLELQATKQKKPIVFNVT
LMNGQSI--TV-PADSASIAKEI--CQFIADKTKLKDVFGFSL-----YIAVFDKVWSL-
GGGRDHVLDAISQCEQLAKEKGTHER-----NAPWRLYFRKE--I-FTPWHNSQEDPIST
DLIYHQVIRGIRF-GEYRCEKEEDLVEIGAKYCYIQFGDS--IHNELVQKALHDCIPVKQ
LKSKPLEKWVSLITYAHAK-APYTQDRLSRQ-------------------------TVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNH----------------------------------------
-------------------------------------------------------FILAV
NWKGICFLDES-E--KQILDLTFPEITGIH---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RAVKSFGQSCTLITLRAEEFVLTSVNSIVIAEL
VVMFLEGLKKRSRFAVAMNEKRPQVFS-EDPAIL-SFKKGDLLILTEDKRLDASS-GWIY
AQNERTGKTGNVFLEEIYIVPSLTKPSSQVLSLLMMSPDQRRTASQNSYMDQPD-EED-L
KVKPYTLEEFSYE-HFRTPEKESISKAVLQKSRGRNQLWAHSKEPLKQPLLKKA----CT
DPDL-------RDLACQAFKH--LP----IMKFMGDYPSKQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

HSSVEVTDQIFVAAIQEE
VLRDEIYCQIMKQL-TENRNRYSVTKGWQLLWLCTGLFPPSKSLLKHAQKFVETRKK-EP
LAMECSRRIQTVMRNGSRKWAPHPVEVEAILQNNTKISHKICFPNETEE--TFDVGTNTK
IRTLCQNIASKLQLSSWEGFSLFVKIADK---VISQNEADYFFDSLRQVTDWNRRNKPVK
D----GAA-MSVAYEVYFMRKLWLNVTPGKDLKADSIFHYHQ------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------LSILPKGDHVWLDSPPTNKIGVAIGGVIKET-KPGKIL
VEDDEGKEHWIRTEQLGVLSPMHPTSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNRHVGELPPHVFAIANSCYFNMKKNKQDQGCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCHQAAEERNYHIFYYMLMGMSAEEKQLLGLGT
PSEYHYLTMGNCTSCEGLDDAKDYAHVRSAMKILQFSDSENWDVSKLLAAILHLGNVEFM
AAVFENLDSSDVMDTPAFPIVMKLLEVQHQALRDCLIKHTILIRGEYVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINATIDTPPSQDPKNVRRAIGLLDIFGFENFHNNSFEQLCI
NFANEHLQQFFVQHVFSMEQEEYRSENIAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDMTMLQKLNSVH----ANNKGFLQPKSIHD--ARFGIAHFAGEVYYQVEGFL
EKNRDV---LSADILTLVYSSKNKFLREMFNLESAES-----------------------
--------TDSTKRPSTLAGQFKQSLDQLMKILTSCQPYFIRCIKPNQYKKPLLFDRELC
LQQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFCVLLPSTERV-QLKDKFRQMTLHIAET
WLGTAKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDALLEIQRGQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAMTIQRVVRGYRH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRGYHSRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILLGFERLQAIARSHVLARQFQALRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

KMVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVVIIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

QRKKAKPWEQFLSR--------HHWP-P-G
SRRKPGPEEQ----RKRAWERIGPQTGQQLALLPRREPGL-AATDKPKNRSDPPAEKR-K
SIYDTIT--DTEMVERVFGFLPAMIGGQEGQAPSRFEDLESKTQTQQLPEIDLDAVPMAE
E---PEEDMDVLAEYTFPKFAATYFQKSASHTHIQRPLRYPLLYHENDADCQAALAVWNI
ILRFMGDLPEPVLYARNSLGGD-SVMQQIHDTLGGAGSARGSSPAGSSQIS--DGRLI-P
ITQHWSPSISLKKKKKI---TSQVA----SRL-SIGEEDFNPDGPISD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIVGYAILKPS--LRDEIYCQ-ICKQLSG-DVRKSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPVGYGPFCAERLRRTCANGVRMEPPTYLELQAVKSKKHIPIQVI
LATGESLMV---MVDSASTSREI--CLHIARKQDLNDHLGFSL-----QVAVYDKFWSL-
GNGRDHVMDAVAQCEQLARERGESQR-----QSPWRIYFRKE--F-FTPWHDSKEDPVST
KLIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AGSKAIQELLPSCVPPRL
YRSKPPERWASLVTAAQAK-PLFEVQATTPQ-------------------------AVR-
EQVVDS---AR-----------------------------------------LRWPLLFS
RLFEVSTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWQGLYFLDQR-E--KTLLELSFPEVMS---------LVTNREAQ---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLLLATLH-DEFEFVSPSSVAIAEL
VALFLEGLKERSVFAMALQDRSL--GPADDATLL-PFKKGDLLILTKKQGLLASE-NWTL
GQNDRTGKTGLVPTACLYAIPTLTKPSAQLLSLLAMSPEKRKLVAREAQPTEPLPEEQ-P
QEEPHTLEEFSLEAFQRAPEKETISRAMPSLSRTRGHLWAYSAEPLRQPLLKRV----HA
NVDL-------RDAACQ-I-F--LD----ILLYMGDYPSRQAWATL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2430)

ALTDQIFSMALQDS
ALQDEVYCQILKQL-TRNSNRYSEERGWQLLWLCTGLFPPSKALLPHAQKFIDTRRKK-P
LALGCSRRLQRVLRTGPRKQPPHEVEVEAAEQKVSRICHKVFFPNDMSE--MLEVGSVSR
VRDVCEGIATRLQLASWEGCSLFIKITDK---VISLKEADFFFDSLRQMSDWVKRHRPQK
E----GAP-LTLPYQVYFMRKLWINVVPGKDLNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDKDQSQLASVPKILKELVPANLTRLMSTEEWKKS-LLLAYDKHRDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLMTS-----YVQQLLSAVNRQRAPGNP
A--------------------------------------

--------------------CAIFRIIHGDHVWLDPPSTSKTGVAIGGIVKET-KLGKVL
IEDDEGKEHWISAADLNTLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLVRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQLYYSHHMGELPPHVFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNPSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSPEEKKLLGLGM
PSDYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILHFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDLMETPAFSFAMNLLEVQFQALRECLIKHTIPIRGEYVSRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINATIFTPPGEDPRSVRRAIGLLDIFGFENFEKNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENISWNYIHYMDNQPILDLLAVKPMSVISLLDEES
RFPQ--GTDVTMLQKLNSVH----ANNKSFLRPKNIHD--TRFGIVHFAGDVYYQAEGFL
EKNRDV---LSIDILNLVQSSKNKFLKEIFNLESPQTKMGHGTIRQLKAGN-Q-F-----
----FKP-SDSIKRPLTLAGQFKQSLDQLMRILTNCQPYFIRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVQIRKSGFPIRYTFEEFSQRFHMLLSSPERK-QFQDKHRQMTLRIADL
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AATCIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RQ-
--AAVTLQATWRGHCQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 889)

F-ELILVGFKRLQAIARSHQLMRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 908)

QRIVQLQAHCRG
YLVRQQFQAKRKAAATKQVHARGLAARWSFPQQK--------------------------
-----------------------------------PVKPRVILASEPKGQGAVLDRKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGPAPTGFEDLEVKTQ--KLPEVDLDAVPMTE
M---PEEDRDDLAEYTFPKFAVTYFQKSANHTHIQKLLKYPLLYHENETDHLAALAVWPI
ILRFMGDLPEPVLYIRNSLSD--SVTRQTHNRLSKDSGTQGPQHNGH-------------
---------------------AQVA----RKL-NPGEEAFNSDVPVSE-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSG-NHKTSSVGRGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPASYGPFCAERLQRTFSNGVRSEPPTWLELQAVKSKKHIPIQVI
LAAGGSLTV---SVDSASTSQEV--CQHIAQKQGLKDQLGFSL-----QVAVYNKFWSL-
GNGSDHVMDAVAQCEQLARERGESQC-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYSQALHGVWS-GEYTFEKEEELVELLARHCYVRLGAT--VKSSAVQELLPSCIPAKL
YRTKSPEKWASIVMAAHAK-APYTQTKAKPL-------------------------AVK-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLYEVTTLS-GPSL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGLCFLDQK-E--NQLLELSFAEVMS---------LVANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRLLLSTLH-EEYEFFSPSSVAIAEL
VALFLGGLKERSVFAMALQDRKATD----DATLL-PFKKGDLLILTKRQGPSASE-NWIP
GQNDRTGKTGLVPVACLYIIPSLTKPSAQLLKLLAMSPEKRKLAAQEVRAAEPLLEEQ-S
TESPYTLEEFSYQ-FFRAPDKETISRSTMPMARNRGHLWAYSPEPLRQPLLKCV----HD
KAKL-------RDPACQIFLDIL--------P-TSDYPSRQSWNSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLALQEP
ALQDELYCQILKQL-THNSVRYSEERAWQLLWLCTGLFPPGKKLLPHAQKFIDSRKKK-L
LAPDCSRRLHRVLRMGPRKQPPHHVEVKAAEQNVSKLRHEVYLPNDTNK--TMEVGSSSR
VRDLCESIATRLQLASWDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAS--TLPYQVFFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYRVQFGSDRSQLASVSKILKELVPQNLTRLMSSEEWKKN-LLLECDKHKNKTVA
EAKVEFLKRICRWPTFGSAFFEVKQTSDPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYSFTKLSS
WSSGSTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQLMNTVNKQRGSRVP
APANP----------------------------------

----------------------KKGNSKGDHVWVDLS----SSVPIGAVVKNNTNPNKIL
IEDDEGKELWIEAQYFKRLQLMHPSSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMILLGDLSEAGMVHNLLIRYQEHKIYTY
TGAILVAVNPYQVLPIYSMDQIQLYYNRRVGELPPHVFAIADNCYFSMKKNKRDQCCIIS
GESGAGKTETTKLILQFLAIISGQHSSIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIELHFNKNGVIEGAQIEHFLLEKSRVCRQAPEERNYHIFYCLLMGMNEDQKKLLSLGT
VSEYNYLTMGHCTSCEGRNDVKDYASLRSAMKVLTFSDSENWDISKLLAAILHLGNVEFS
AAISGNLDCSDVVDTPHFLAAVKLLEVKNMELQACLTNHYITIRGEGVSRPLNILQASDR
RDAFVKGIYGHLFLWIVNKINAAIFKKPSQDPQNVHRSIGLLDIFGFENFHTNSFEQFCI
NFANEHLQQFFVRHVFTIEQEEYHVENISWNYIHFNDNRPTLDLLALKPMNIISLMDEES
KFPK--GTDATMLQKMNHVH----SNSKIYVAPKNMHD--MKFGIAHFAGLVHYQAEGFL
EKNRDV---LSTDIIQLVYSSQSKFLKHIFQLESSHIQLGHGTIRLARSSDS--------
----TSKNADATKRPSTLASQFKQSLDQLMKILNNCQPYFIRCIKPNEFKKPMLFDRELC
IQQLRYSGMMETVKIRKSGYPIRFTFEDFFQRYKLLLPVPARV-ELQDKPRQGTLRISET
WLGKNEDWKMGKTKVFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDYQDTLLETQRSQELY

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KNAVIIQKAIRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLSQKR-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVAIQAMWRGYAGRKNY-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KTILLGFERLQAIVRRHQLAKQYNATR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 906)

AKIIQFQARCRG
YLIRR

ENSGT00900000140810_6_Linker_5_6 (906, 912)

KIAEKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 928)

QAVVVIQAHTRGMFAR

ENSGT00900000140810_6_Linker_6_7 (928, 1264)

QGCMKRKKQE-----------------------
-----------------------------------HLTVPEKEEDDSKNQMDQPARNL-H
SIYDPIS--DTEMVEKVFGFLPMIIGGQKGQAPQGFEDLETTT--QKLTEIDLDTIPMSV
ESEE---DMDDLDEYTFPRFAATYFQKAASHTHIRRPLYYPLLYHEDDEDFKTALIVWKI
ILRFMGEFPEPQLFAKSSNLQHTSITREIKDTLGKKNAAQFLTDSMSEKIIL--------
------------------------------DC-SFREEFMEESGGGGG-------KGLST
IET

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1370)

VHFMLHAHCLCPS--YRDEIYCQ-ICKQLSE-NYNKNSFARGWILLCLCIGCF--PP
SEKF-IKYLLNFISKGPVGYRSFCTERLRRTCANGLRTEPPNSLELQAVKSKNRILFNVT
LMNGESLTI---TADSASSSKEV--CQHIAEKLHLKDLFGFSL-----YIAVYDKEMGTL
NPVSFHICVLCGNCNILANFLEESAK-----QSPQKYIYFSR---VLTHYKDSKDEYLKE
SMVHGHILRPNTSTFYFTNSREEDLVEVVAKHCYIEFGSS--IQRSDIQKTLSTCIPGKI
LKTKSQEQWVNLVTAAYAK-VPCIQSHSSPL-------------------------LVK-
EEIGTM---VC-----------------------------------------FQWPLLFS
KFFEVTKIS-GPSL----------------------------------------------
----------------PKNQ----------------------------------------
-------------------------------------------------------LILAI
NWKGLCFLDKS-E--KKLLDLTFPEITGIV---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RALQVSKQNFTLSTLKTEEYVFISNESVAIAEL
VAIFLGGLKKRSIYAMAIRDKKST------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------MSAFRLGDHVWLNPLSANKTSVAIGSIVKET-KPGKIL
VVDDEGKEHWIQAKDLDTLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGELNEAGMVHNLLIRYRQHKIYTY
TGSILMAVNPFQVLPLYTLEQVQLYYNRHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIDIHFNPNGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYGMLLGMTAEEKKLLSLGT
PSEYHYLTTGNCTSCEGLNDAKDYAHVRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMETPAFPTVLKLLEVEYQALRDCLIKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINTAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYLSENIAWDYIHYNDNRPTLDLLALKPMSIISLLDEES
HFPQ--GTDTTMLQKLNSVH----ANNKAYLQPRNIHD--ARFGIAHFAGEVYYQTEGFL
EKNRDM---LSTDILTLVYSSKNKFLKEIFKLESAGTKLGQSTIIQASAGS--QL-----
----FKS-ADSSKQPSTLAGQFKKSLDQLMKILTSCQPYFIRCIKPNEYKKPLLFDRDLC
LRQLRYSGMMETVHIRRSGFPIRYTFQEFAQRFGVLLPSAVRL-QLRDKARQMTLRIAEM
QLGTDKEWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDNQDTLLEVQRTQTLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAINIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQARWRGYYNKRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KQILLGFERLQAIARSQWLAKQYQTMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

QQQKANGP----------------------
--------------------------------------LV-IPAEGQKSQSILPTRKR-K
SIYDTIT--DTEMVEQVFGFLPSMIGGQEGQAPWRFEDLEAK--SQKLPEVDLDTVPLVE
E---SEDDVDGLAEYTFPKFAATYFQKSASHTHIRRPLRYPLLYHEEDADCSAALAVWNI
ILRFMGDLPEPVLFARNGPPGG-SVTRQIRDSLGREGGTRSPPHCGST--QKSSRRDR--
-GSKDISSMKLKRSSKI---TSQVT----SQL-NIGEEAFEPDGPISD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIVGYAILRPN--LRDEIYCQ-ICKQLSE-NFKTSCLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPAGYGPFCAERLRRTYANGVRTEPPTWLELQAVKSKKHIPIHVI
LVTGESLTV---MVDSASTSREV--CLHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDTVAQCEQLARDRGENER-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
QLIYRQVLHGVWS-GEYNFEKEDDLVQLLAKHCYVQLGAS--VGSEAVQELLPSCIPSKL
YKTKPPEKWASLVTAAHAK-AQYTQKQAKPL-------------------------AVQ-
EQVVDT---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGMYFLDQR-E--KILLELSFPEVVS---------LITNREAQ---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLVLSTLHEEEYKFMSPSSVAIAEL
VAMFLEGLKERSVFAMALQNRKATDDTT----IL-PFKKGDLLILTKKQGLLASE-NWTL
GQNDRTGKTGLVPTACLYTIPTVTKPSAQLMSLLAMSPEKRKLAAQEVQPTEPLPEEQ-P
KEKPHTLEEFSYEF-FRAPEKETVRRTMLPLARTQGHLWAHSSEPLRQPLLKQV----HA
NAEL-------RDPACQ-I-F--IG----ILRYMGDYPSRQAWT

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2430)

SVELADQIFSLALQES
ALRDEVYCQILKQL-THNTTRYSEERGWQLLWLCTGLFPPGKALLPHAQKFVDTRRKK-L
LAPDCSRRIQRILRTGPRKQPPHPVEVEAIEQNISRICHKIYFPNDTSE--MLEVGTYTR
VRDVCQGIATRLQLSSWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVTPGKDVNAD

PF00373 // ENSGT00900000140810_6_Domain_14 (2556, 2661)

TVLHYHQELPKYLRGFHKCSQEDAV
HLAGLIYKAQFDNNRSQLASIPKILRELVPENLTRLMSSEEWRKN-ILLAYDKHKDKTVE
EAKVAFLKGICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLARGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQRGSQTP
ALADP----------------------------------

----------------------MSGLRLGDHVWLNPTSANKISVAIGGIVKET-KPGKIL
VEDDEGKEHWIQAGDLDTLSPMHPNSAEG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTVEQIQLYYNRHVGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNSSGVIKGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEEKKLLGLGT
PSEYHYLTMGNCTSCEGINDSKDYAHIRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMETPAFPTAMKLLEVKDQALRNCLIRHSITVRGEFVTRPLNLVQAADR
RDAFVKGIYGHLFLWIVGKINAAIFTPPDQDPKNVRKTIGLLDIFGFENFQKNSFEQLCI
NLANEHLQQLFVQHVFTVEQEEYRAENIAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
HFPQ--GTDTTLLQKLKSVH----AKNKAFLQPKNIHD--ARFGIAHFAGEVYYQTEGFL
EKNRDV---LSEDILTLVYSSQNKFLREIFRLESVETKRGLGTIIQANAGS--RL-----
----FKS-SDSGKRPSTLASQFKQSLDKLMKILTNCQPYFVRCIKPNEYKKPLLFDRELC
IRQLRYSGMMETVHIRKSGFPIRYSFEEFSQRFRVLLPSAVRK-ELRDKFRQMALRIAEM
WLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDNHDTLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAVSIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRGYYNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILLGFERLQAIARSHLLTKQFQALRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAR

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RKAVVVIQAYARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1263)

RRQKASEP----------------------
--------------------------------------LA-IPAVEQKSPNVVPSRKR-K
SIYDTIT--DTEMVEQVFGFLPSLVGGQEGPAPPRFEDLDVK--TQKLPEVDLDTVPMLE
E---PEEDEDGLAEYTFPKFAMTYFQKSASHVHIRRPLRYPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPVLFARNTLRDG-SVMRQIHDALDKGSSTQLPQQGGSS--QRPSRRDR--
-GTKDISSMKLKRSSRV---TGQVA----SQL-NIGEEA--SDGPLSE-------RPMSN
LE

PF00784 // ENSGT00900000140810_6_Domain_7 (1263, 1368)

KVQFIVGFAILRPS--LRDEIYCQ-ICKQLSE-NYKKSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFIGQGPASYGPFCAERLKRTCVNGVRMEPPSWLELQAVKSKKHIPIHVT
LATGESLTI---MVDSASTSREV--CLHIAHKQGLSDCLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLARERGETER-----QSPWRLYFRKE--F-FTPWHNSQEDPVST
QLIYRQILHGVWS-SEYSFEKEEELVAFLAQHCYVHLGAS--ARSEAIQELLPSCIPSKL
YRTKTPEKWASLVTAVHTK-APYTQKRATPL-------------------------SVQ-
EQVVDT---AC-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTH----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQK-E--KMLLELSFLEIMS---------LITNREAR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLVLSTLHEEEYEFQSPSSVAIAEL
VALFLEGLKERSVFTMALQDRKATDDV----TFL-PFKKGDLLILTKKQGLLASE-DWTL
AQNDRTGKTGLVPTACLYAIPTVTKPSAQLLSLLAMSPEKRKVAAQEGRLAEPPPEEQ-P
EEKLHTLEEFSYEF-FRAPEKETLSRAMLPMARTRGHLWAHSPEPLRQPLLKRV----HA
NVEL-------RDVACQ-I-F--IA----ILRYMGDYPSRQAWTSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSLALQDA
ALQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPSKALLPHAQKFIDTRRRK-V
LAPDCSCRIQRVLRMGPRKQPPHHVEVEAVEQNIFRICHKIYLPNNTDE--MLEVGTNAR
VRDVCESVATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAR-VTLPYQVYFMRKLWLNVAPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSQEDAI
HLAGLIYKAQFADDRSQLASIPKILRELVPENFTRLMSSEEWKKN-ILLAYDKHRDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIVLIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQTLMSAVNKQRGSRAP
PANP-----------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MNGQSI---TVPADSASIAKEI--CQLIADKTKLKDTFGFSL-----YIAVYDKVWSL-
GSGRDHVMDAISQCEQLVKEQGAHER-----NAPWRLYFRKE--I-FTPWH

PF00373 // ENSGT00900000140810_6_Domain_9 (1492, 1581)

NSKEDPVST
ELIYHQIIRGVRF-GEYRCDKEEDLVEIGAKYCYIQFGDS--IRNELVQKLLQDCIPAKL
LKSKPQEKWVSLLTYAHAK-APYTQDRLSPQ-------------------------TVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNH----------------------------------------
-------------------------------------------------------FIVAI
NWKGICFLEES-E--KRLLDLSFPEITGIH---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RAVKSFGQCCTLITLRAEEFVLTSVHSVVIAEL
VVLFLEGLKKRSQYAVAMQDSKQ---Q-GDPAIL-AFKKGDLLILTQDKELEANRGAWVY
AQNERTAKTGAVSLEAIYVIPSIAKPASQILSLLMMSPDQRRLASLTSRTEEAE-EEE-V
KVKPYTLEEFSYE-HFRVPEKESLSKAVLHKSRGRSQLWAHSKEPLKQPLLKKV----CA
DPGL-------QDLACQAFI----A----IMKFMGDYPSKQAR

PF00784 // ENSGT00900000140810_6_Domain_12 (2324, 2431)

SSVELTDQIFVAAIQEE
VLRDEIYCQIMKQL-TENSNRYSVNSGWQLLWLCTGLFPPSKSLLKHAQKFMETRQK-EP
LALDCSRRIQRVMRYGCRKWAPHNVEVEAI

ENSGT00900000140810_6_Linker_12_13 (2431, 2441)

QQNITKISQK

PF09379 // ENSGT00900000140810_6_Domain_13 (2441, 2541)

VCFPNDTEQ--VFEVGTNSR
IRSLCQNIASKLQLSSWEGFSLFIKTTDK---VISQNEADYFFDSLRQVTDWTRKNKPVK
D----GGA-VAVTYQVYFMR

ENSGT00900000140810_6_Linker_13_14 (2541, 2558)

KLWLSVTPGKDLKADSI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

FHYHQELPKYLRGYHKCSKEEAA
QIAGLIYKVRFDRDRSQQAAIPKILRELVPDNLVRAMALEEWKKN-IISAYSRHEGKTVD
EAKVAFLKMIHRWPTFGSAFFEVKQTSEPNFPDIVLIAVNRQGVSLIHPKTK--------
-----------------------------------------------DILIVYPYNKISN
WNSGSTFFHMTIGNLVRGSRILCETSLGYKMDDLLTS-----YVQLLMNAVNKQRNPRLP
A--------------------------------------

----------------------MSVFRLGDHVWLDPPSSSKTGVAIGGIVKET-KLGKTL
IEDDEGKEHWVHAEDLSTLRPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLSLGM
PSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQATDR
RDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSIH----ANNKSFLSPRSIHD--TQFGITHFAGDVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQVK--AGSQL-----
----FKS-SDSIKRPVTLASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERM-QFQNKPRQMTLHIADL
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTVLEIRRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAIRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYSQRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILVGFERLQAIARSHLLMRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVIIQAHARGMVVRKS

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YWQQK--------------------------
-----------------------------------STGPQVILAKEPKAQVAVHERKR-K
SIYDTVT--DTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLHEVDLDTVPMMA
M---PEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALAVWII
ILRFMGDLPEPVVYGRNSLTGS-SVMRQIHDKLGKDSVTQ---HNRS-------------
---------------------SQVA----SQL-NFGEEAFKFDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPPSYGPFCAERLRRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGKSLTI---SVDSASTSREI--CQHVAQKQGLRDNLGFSL-----QVAVYDKFWSL-
GSGCDHLMDAVAQCEQLARERGESQR-----QAPWRIYFRKE--F-FTPWHDSQEDPVST
ELIYHQVLRGVWS-GEYNFEKEEELVELLARHCYVQLGAT--VKSNAVQELLPSCVPSKL
YRTKSPEKWASLVTAAHAK-AQYTQSKATPL-------------------------AVR-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGMYFLDQK-E--RTLLGLSFAEVMG---------LVANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGKKLLLATLQ-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRRATD----DITLL-PFKKGDLLILTKKQGLLASE-NWAL
GQNDRTGKTGLVPTACLYTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVQALEPPLEEQ-L
TESPYTLEEFSYQ-FFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSV----HD
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLALQDP
ALQDELYCQILKQL-THNSIRFSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKK-P
LALDCSRRLHRVLRVGPRKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSK--SMEVGSSSR
VRDLCEGVATRLQLASWDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAS-VTLPYQVFFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLGGLICKIQFGSDSSQLASVSKVLKELVPQNLTRLMSSEEWKKS-LLLECDKNKRKTVA
EAKVEFLKYMYRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYPFTKISS
WSSGNTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQLLNTVNKQRGFRAP
APANP----------------------------------

----------------------ESVFECGDHVWLDSSS-TKMSVAIGGIIKET-KPGKIL
VEDDEGKEHWIPTENSDALRLMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMICLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTMEQVQLYYGRHVGELPPHVFAIANSCYFNMKKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEG--NPSPICCDPGTLFR
KFLPVHDNPKPH--GLHSLAYY-LCEYLSSQAPEERNYHIFYCMLMGMNAEEKSLLGLGM
PSEYHYLTMGNCMSHEGLNDAKDYAHVRSAMKILLFSDSENWDISKLLAAILHLGNVEFM
AAVFENLDSSDVMESTAFPIAMKLLEVQHQVLRDCLIKHTILIRGEYVTRPLNIAQAADR
RDAFVKGIYGHLFLWIIKKINASIFPPPSPDPNSVRRSIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENITWDYIHYTDNRPTLELLALKPMSIISLLDEES
RFPQ--GTDTTMLQKLTSVH----ASNKIFLKPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILALIHSSKNKFLRKIFDLESAETKLGHGTVRQAKAGS--QL-----
----FKP-TDSTKRPSTLAGQFKQSLEQLMRILTSCQPYFIRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFEEFTYRFRVLLPSAERT-QLQDKFRQMTLRILDV
CLQTDRDWKMGKTKVFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTLLEIQRGQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVRIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAEWRGYCNRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILVGFERLQAIVRSHPLTRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRVVRLQARCRG
YLVRQQVQAKRRAVLVIQAHARGRATRQILQQQK--------------------------
-----------------------------------AQEPLAILDEEQRRPKPLPEKKC-K
SIYDTIT--DTEMVEKVFGFLPSMIGGQEGPAPARFEDLEAKTQ--TLPEIDLDTVPITE
E---IEEHVDSLDEYTFPKFAATYFQKSATHTHILRSLRYPLLYHENDTDYSAALAVWNI
ILRFMGDLPEPLLYARNSVSDD-SVMRQIHDRLGKDSIFGGPQHGGT-------------
---------------------AQVA----SQL-NIGEEAFDPDGPVSD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NFKMSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIDHGPASYGPFCAERLRRTCANGVRAEPPTWLELQAVKSKKHIPIQVI
LAAGESLTI---MVDSASTSREI--CLHIAQKQGLKDHLGFSL-----QVAVYDKFWSL-
GSGRDHLMDAVAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
ELIYRQVLQGVWS-GEYSFEKEEPLVELMARHCYVQLGAS--AGINHIQELLPSCLPRKL
YKTKTPEMWASLITAAYTK-APHTQKRLMPQ-------------------------AVR-
AQVVDA---AL-----------------------------------------LQWPLLFS
RLFQVTPVS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------MILAV
NWKGLYFLDQR-E--KTLMELSFPEVMG---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AVGGQRLLLSTLH-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRKATD----DVTLL-PFKKGDLIILTKNQELLASE-NWTM
GQNDRTGKTGMVPTACLYSIPTVVKPSAQLLSLLAMSPEKRRLAAQEMQHSELLPEEQ-P
KEAPHTLEEFSLQ-FFRAPEKETIGRARLPLARNRGHLWAYSTEPLRQPLLRRV----QD
KADL-------RDIAFT------PI-----LKYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSLALQDS
ALQEEVYCQILKQL-TNNSNRYSEERGWQLLWLCTGLFPPSKALLPHTQKFIDTRRKK-L
LASDCSRRLQRVLRTGPRKQPPHQVEVTAAEQNVSRLSHQVHFPNDTSE--ILEVGSSSR
VRDVCEAITARLQLASWEGCSLFIKITDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVSPGKDINADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLICKAQFDNDRSPLASFPKVLKELVPENLIRLMSSEEWKKS-LLLECDKHRDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIVLIAINRHGVMLIHPKTK--------
-----------------------------------------------ELLITYPFTKIAS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAVNRRRGPRPP
ALAHS----------------------------------

----------------------KMCHQKGDFIWLESPSSSEFSVPIGAVVKIS-ESGRFL
VEDDEGKEYWITTRNIGTVRPMHPASVHG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMICLGDLNEAGMVRNLLIRYKEHKIYTY
TGSILVAMNPYQVLPLYTTEQIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTESTKLILQFLAAISGQHSWIEQQILE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNQNGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNLEQKKMLNLGT
ASEYTYLTMGECTSCEGRNDAKEYAHIRSAMKILMFADSEHWDISKLLAAILHLGNVEFE
AVVYDNLDCSAVLDSAHFSIATKLLEVDAGELHNSLTNHSIIIRGESVSMPLSVAQAAGV
RDAFVKGIYGLLFLWIVNKINAAIYNPPSPDHKNTHRSIGLLDIFGFENFNTNSFEQLCI
NFANEHLQQFFVLHIFKLEQEEYMAEHISWTHIDFTDNSSALEVIALKPMNIVSLIDEES
RFPK--GTDTTMLNKINMHH----GRSKIYIPPKNVHD--TVFGINHFAGVIYYQSKGFL
EKNRDM---LSSDIMQLVHSSKNKFLRQIFQVDTT-------------------------
------MGSDTTKRLSTLGGQFKQSLEQLMKILGSCQPYFIRCLKPNDHKKPMQFDRELC
IRQLRYSGMMETIRIRKAGYPIRYSFADFFERYKILQPVSARE-QLKNDVRQCCISVCER
VIGKRDEWKIGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHHDTVLEVQREKGLR

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

EKAILIQKVMRGFKD-RKC

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--CAVIIQTAWRGYCCRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KMILLGFERLQALFRSRQLMKQYEAA

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 906)

RASVIKFQALCRG
FLMRQ

ENSGT00900000140810_6_Linker_5_6 (906, 912)

KAAEQM

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 932)

KAVCVIQAYARGMFARRSF-

ENSGT00900000140810_6_Linker_6_7 (932, 1259)

QRMKREQQHKLEARRLHLKDDKYLAPIIR
EKK----V----------MKASHTIERVGRCKESPAVPEP---KGYVEKLKKQDVVND-E
HEYDAIS--DQEMVDRVFGFLPSLIGGQEGQAPLGFEDLEAKTQKQKLNEVDLDAIPMIM
ELEE-EEETDDQAEYTFPKFAATYFQGSATHTFSRRPLRHPLLYHDEKDDILISFAIWTT
ILQFMGDLPESV---KNTSSKSTSEVTQVYDSFGRKSHLQP---SGSYSPDLV-DNRKDS
KFAKVISSVKLKQNSKM---TGKVA----IQM-TNGEDTLREESSASE-------GPT

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1369)

SN
LEKVHFIINNAIHHPD--IRDEIYCQ-ICKQLTE-NNKKQSRNRGWILLALCLGSF--SP
SEKF-EKYLQNFMRSGPSLNALYCQERLRRTLMNGTRSEPPSWLELQAALRKKPIVLSVT
LMNGNSI--TV-LADSASTAKEI--CQMVADKMQLKDTFGFSL-----YIALYDKYSSL-
GSGREHIMDAISQCEQQQREKGGHER-----HTPWRFYFRKE--I-FTPWHNSKEDPVST
ELIYHQIIRGIRY-GEYRCEKEEDLVEIGAKYCYVQVGES--IQNELVLKILQECIPSKA
AESKSQEKWVSLITYAHAK-ALYTQDRLSPQ-------------------------SVK-
EQVVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNN----------------------------------------
-------------------------------------------------------FIVAV
YCKGICFLDDS-E--KRLLDLSFPEITGIH---------TSSECSFSAELG---------
---------------------------N------------------------------AD
Y----------------------------------------------------------W
ELLVSTSSAGPSS---NS--SYLNWPIMAIKTFGQSCTLTTLRAEEFVLTSVNSVVIADL
IVKFLDELKKRSQYAVAIIENKPQ--E-NDPTIL-AFKKGDLLILTQDKSQGETQ-DWIY
AQNERTDKFGLVSREAIYVIPTVTKPSSQILSLLMMSPEQRRLASLNSRTEETE-EEE-A
KVKPYTLEEFSYE-HFRVPEKESISKAVLHKSRGRSQLWAHSREPLKQPLLKKV----CT
NLDL-------WDFACQSFIDILPA----IMRYMGDYPSKQER

PF00784 // ENSGT00900000140810_6_Domain_12 (2324, 2431)

SPMELTDQIFVAAIQEE
LLRDEIYCQIMKQL-TENNNRYSLNSGWQLLWLCTGLFPPSKPLLNHAQKFMETRQK-EK
LASDCRRRIQRVMRSGCRKWAPHSVEVEAIQRNITKIPQKVYFPNGTEQ--VFEIGTNAK
VRSLYQTIASKMELNYPEGFSLFVKIADK---VISQNEADYFFDSLRQVSDWTRKNRPGK
E----VVP-ITTNYQILFMRKLWLNVVPGKDLKADCI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

FHYHQELPKYLRGYHNCSKEDAI
QLAGLIFKVYANNDKTHYAAIPKILKELVPENMIRTASPEEWRRN-IISATNKHEQKSVD
EAKIAFLKYIYRWPTFGSAFFEVKQTSEPNFPDIVLIAINKQGVSVIHPKTK--------
-----------------------------------------------EILMVYSFTKISN
WSSGSTYFHMTIGNLVRGSRILCETSLGYKMDDLLTS-----YVQLLMNAVNKQKNPK--
---------------------------------------

----------------------SSLCLQGDHVWLNPLSANKTSVAIGCIVKET-KPGKIL
VEDDEGKEHWIRAEDLATLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLTRYRQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYCSHHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMAAEEKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILMISDSEHWDLSKLLAAILHLGNVQFM
AAVFENLDSSDVMDSPAFPTVLKLMEVEYQALRDCLIKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINTAIFTPPGQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYLSENIAWDYIHYNDNRPTLDLLALKPMSIISLLDEES
RFPK--GTDITMLQKLNNVH----ANNKAYLQPKNIHD--ARFGITHFAGEVYYQTEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFKLESAGT-----------------------
-----KS-TDPSKQPSTLAGQFKKSLDQLMKILTGCQPYFIRCIKPNEYKKPLLFDRELC
IRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVVLPSAVRL-QFLDKARQMTLRIAEM
RLGTDKEWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDNQDTLLEVQRSEAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 834)

DKAAVNIQRVLRGYKSSRKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYYNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KQIILGFERLQAIARSQLLAKQYQIM

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RQRMVQLQALCRG
YLVRQQV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

RQQKANAVRRDEQQH---RALTRHSY-P-L
RVQSHYCSRS----SHHLGHVGHPQEHAGCG-IEEASCSV-SPTEEQKSQTALPTRKR-K
SIYDTIT--DTEMVEQVFGFLPSMIGGQEGQAPQRFEDLEAR--TQKLPEVDLDTVPMVE
E---SEDDTDSLDEYTFPKFAATYFQKSASHTHIRRPLRSPLLYHENDADCSAALAVWSI
ILRFMGDLPEPVLFAGNGLHGG-SVTQQIHDTLGRENSTQPPQHGAST--QTPAGSCV--
-QT-KCIEIQLKRSPRI---TGQVT----SQL-NIGEESFEPDGPISD-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVQFIVGYAILRRN--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPAGYGPFCAERLKRTYANGVRTEPPTWLELQAVKSKKHIPIHVA
LETGESLTV---MVDSASTSREV--CQHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLARERGENER-----QAPWRIYFRKE--F-FTPWHDSQEDSVST
QLIYCQVMHGVRS-GEYTFEKEEELVQLLAQRCYVQHGAS--VGSEAIRELLHSCVPSKL
YRTKPPEKWASLVTAALAK-AQYTQKQAKPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGIYFLDQK-E--KMLLELSFPEVMS---------LITNREAQ---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLVVSTLHEEEYEFMSPSSVAIAEL
VAMFLEGLKERSVFAMALQDRKATGAQPG-GEGR-IVWKGDLLILTKKQGLLASE-HWTL
GQNDRTGKTGLVPTACLYAIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEPLPGEQ-P
KDKPHTLEEFSYEF-FRAPEKETVSRAMFPLARTRGHLWAHSPEPLRQPLLKCV----HA
SAEL-------RDLACQ-I-F--ID----ILPYMGDYPSRQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

WTSVELTDQIFSLALQDS
ALQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFVDTRRKQ-L
LAPDCSRRIQSILRTGPRKQPPHPMEVEAVEQNISRICHKIYLPNDTSE--MLEVGTHTR
VRDVCQSVATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVTPGKDVNADTILHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDRSQLASIPKILRELVPENLTRLMSSEEWKKN-ILLAYDKHKDKTVG
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------EPLTTYPFTKISS
WSSGSTYFHMALGSLARGSRLLCETSLGYKMDDLLTS-----YVQQLLSSVNKQRGSQAP
A--------------------------------------

----------------------MSVFRLGDHVWLDPPSSNKTGVAIGGIVKET-KLGKTL
IEDDEGKEHWISAEDLSTLRPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHVFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEEKNMLGLGM
PSEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFPFAMKLLEVQHQALRDCLIKHTIPILGEFVSRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSIH----ANNKSFLRPKSIHD--TRFGIAHFAGDVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNLDLPQTKLGHGTICQVKTKTGGQI-----
----FKP-SDSTKRSVTLSSQFKQSLEQLMKILTNCQPYFVRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERV-QFQNKHRQMTSRIADL
CLGTDKEWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAIRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLRQKR-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVTLQAVWRGHNQRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILMGFERLQAIARSHLLMRQFQTMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVIIQAHARGMVARKS

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YWQQK--------------------------
-----------------------------------SSGPPVILAKEPKGQGVALDRKR-K
SIYDTVT--DTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLHEVDLDTVPMTE
M---PGEDVDGLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALAVWII
ILRFMGDLPEPQAYGRSSLTGS-SVMRQIHDRLDKDSVTQGPQHNRS-------------
---------------------TQVA----SQQ-NIGEEVFKFDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPASYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGRSLTI---SVDSASTSREI--CQQIAQKQGLRDKLGFSL-----QVAVYDKFWSL-
GNSCDHVMDAVAQCEQLAWERGESQR-----QAPWRIYFRKE--F-FTPWHDSREDPVST
ELIYHQVLRGVWS-GEYNFEKEEDLVELLARHCYVQLGAT--VKSNAVQELLPSCVPSKL
YRTKSPEKWASLVIAAHAK-APYTQSKATPL-------------------------EVK-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGMYFLDQK-E--RTLLGLSFAEVMG---------LIANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGKSLLLSTLH-EEYEFASPSSVAIAEM
VALFLAGLKERSVFAMALQDRKATD----DVTLL-PFKKGDLLILTKKQGLLASE-NWVL
GQNDRTGKTGLVPTACLYTIPSVTKPSAQLLNLLAMSPEKRKLAAQEVQASEPPLEEQ-L
TELPYTLEEFSYQ-YFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSV----HD
KAKL-------RDSACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLALKEP
ALQDELYCQILKQL-THNSIRFSEERAWQLLWLCTGLFPPGKALLPHAQKFIDSRKKK-P
LALDCSRRLHRILRVGPRKQPPHHVEVKAAEQNVSKLHHEVYLPNDTNK--TLEVSSSSR
VRDLCEGIATRLQLASWDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAS-TTLPYQVFFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYMRGFHKCSREDAI
YLAGLIYKIQFGSDRSQMASVSKILKELVPQNLTRLMSSEEWKKS-LLLECDKHKNKSVA
EAKVEFLKRIYRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLDTFPFTKISS
WSSGNTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQILSAVNKHRGFRAP
APAQPDHENLWRLPVCPPDRPQGTESPTQACRKCCVLSI

----------------------MSGLRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDFDALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIHNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQALEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDTKDYAHIRSAMKILQFSDSENWDLSKLLAAILHLGNVGFT
ASVFENLDSSDLMETPAFPTVMKLLEVQHQELQDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAVGLLDIFGFENFKNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYHSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPK--GTDLTMLQKLNSVH----TNNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETKLGH-TIRQAKAGN--HL-----
----FKS-ADSTKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFQEFSQRFGVLLPSAVRM-QLRDKFRQMTLSITDM
WLQTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQGLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALHIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILVGFERLQAMVRSQLLARQYQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RKAVVVLQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ASVPLVIPAEAQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTE--KLPEVDLDAIPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNF
ILRFMGDLPEPVLYARSRQQGG-SVMPQIQDTLGRGRGAQALQHGGSAQ-----------
-----------------------VA----SQL-SIGEEALEPDGLSAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRVEPPTWLELQAVKSKKHIPIQVI
LATGESLTI---PVDSASTSREV--CVHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESHR-----QSPWRIYFRKE--F-FTPWHNSQEDPVST
ELIYRQVIHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACTK-APYTQKQATPL-------------------------AVR-
EQVVDA---AL-----------------------------------------LQWPLLFS
RLFEVITLS-GSRL----------------------------------------------
----------------PKTK----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQQ-E--KTLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSMFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLATQEGQPAELQTKEP-P
KEKPHTLEEFAYE-FFRAPEKETGSRAMLPLSRARGHLWAYSSEPLRQPLLKQV----HA
NIDL-------WDVTCQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFMLALQHE
ALRDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRHIQRVLRTGPRKQPPHQVEVEAAEQNVSRICHKIFFPNDTSE--MLEVGANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVAPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSQEDAI
HLAGLIYKAQFDNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-IPLAYDKHKDKTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMDKQRGSKAPALAST
---------------------------------------

----------------------------GDHVWLDSPSTSKMSVAIGSVIKET-KPGKVL
VEDDEGKEHWIRAEDLAALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQLLPLYTLEQVQLYYGRHMGELPPHVFAIANSCYFNLRKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIHNDNSSRFG
KYIDIYVNTSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSTEEKKLLDLGT
PSEYHYLTMGNCTSCEGLNDSKDYAHIRSAMKILLFSDSENWDISKLLAAILHLGNIEFM
AAIFENLDSSQVMETPTLPTVIKLLEVQHQPLRDCLTRHTILIRGEHVTRPLNMAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFAMEQEEYRSENLAWDYIHYTDNQPTLDLLALKPMSVISLLDEES
RFPK--GTDLTMLQKLNGVH----ANNKAFLKPKNIHD--ARFGITHFAGEVYYQVEGFL
EKNRDV---LSADILTLVHSSKNKFLRQIFNLESAETKLGHGTIRQAKAGN--QI-----
----FKS-TDAAKRPSTLAGQFKQSLEKLMKILTRCQPYFVRCIKPNEYKKPLLFDRALC
LRQLRYSGMMETVRIRKSGFPVRYMFEEFARRFRVLLPSAQRA-QFQDNFRQMTLSIADL
CLETDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTLLEIRRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVSIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRGYCSRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KMILVGFERLQAIARSHILSRQFQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRCF

ENSGT00900000140810_6_Linker_6_7 (931, 1263)

QQRK--------------------------
-----------------------------------ANEPVAIPAQEPKDQSALPTKKR-K
SIYDTVT--DTEMVEKVFGFLPSIIGGQEGQAPAGFEDLETKSP--KLPEIDLDTVPTVE
E---PEDDPEGLAEHAFPKFAVTYFQKSASHTHIRQLLRYPLLYHDNDTNYSAALSVWTI
ILRFMGDLPEPVLYAKNSLRES-PVMRQIHDRLGQRPTGQGSGHGGSAQ-----------
-----------------------VA----SQL-GTGEEVFDPDGPISD-------RPMSN
LE

PF00784 // ENSGT00900000140810_6_Domain_7 (1263, 1368)

KVHYIVGYAILRPS--LRDEVYCQ-ICKQLSE-NPKASSRARGWILLSLCLGCF--PP
SERF-LKYLLNFIGQGPAGYGPFCAERLRRTCANGVRMEPPTWLELQAVKSKKHIPIQVI
LVTGQSLTI---TVDSASTSREV--CLQIARSQDLTDYLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAQERGESQR-----QAPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQVLHGVWS-GEYSFDREEELVELLARHCHVQLGAS--SGSEAVQGLLPSCIPPKL
YKTKPPERWASLVTAAQAK-ASYTKTGATAL-------------------------VVR-
QQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGLHFLDQR-E--RTVLELSFPEVTS---------VVTNRA-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ARGGQRLLLSTLRGEEYEFTTPSSVAIAEL
VALFLEGLKERSVFAMALQDRKATE----DVTLL-PFKKGDLLILTKKQGLLTSE-NWTL
GQNDRTGKTGLVPTTCLYAIPTVVKPSAQLLSLLAMSPEKRKLAAQEG-PEEPLPEEL-P
KEKPHTLEEFSY-EFFRAPEKETISRAMIPLARTQGHLWSYSLEPLRQPLLKRV----HD
KADL-------RDAACQIFLDIL--------SCRCDYPSRQAWPAL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQVFSSALQEP
ALQDEVYCQILKQL-THNPNRHSEERGWRLLWLCTGLFPPGKALLPHAQKFIDSRRKQ-K
LAPDCSRRIQRVLRTGPRKQPPHQVEVDAAEKSISRICHEVYFPNDTSE--MLEVGPNNR
VREVCEAVAARLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRKNKPQK
E----GAP-ATLPYQVYFMRKLWLSVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAT
HLAGLIYKAQFDNDQSQLANVPKILRDLVPENLTRLMSSEEWRKS-LLLECSKHRNQTVQ
EAKVAFLKYICRWPTFGSAFFEVKQASEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLASYPFTKLSS
WSSGSTYFHMALGSLGSSKRLLCETSLGYKMDDLLSS-----YVQQLLSVVNKQRGSRGP
PLANP----------------------------------

----------------------MSVFRLGDHVWLDPPSTNKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDLGALGPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGIVHNLLIRYRQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNRHVGELPPHIFAIANNCYFNMRRNKRDQSCVIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ATPILEAFGNAKTVRNDNSSRFG
KYIEIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMRAEDKELLCLGM
PSEYHYLTMGNCTSCDGFSDAKDYAHVRSAMKILQFSDSENWDLSKLLAAILHLGNVEFM
AAVFENMDSSAVTETPAFPAVVKLLEVQHHALQDCLIKHTILIRGEYVTRPLNITQAADR
RDAFAKGIYGHLFLWIVKKINTAIFMPPAQDPKSVWKAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSEGIDWDYIRYTDNRPTLDLLALKPVSIISLLDEES
RFPQ--GTDITMLQKLNSVH----ASNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSADILTLVYSSKNKFLREIFNLESAETKLGHGTIRQAKAGS--QL-----
----FKS-ADSAKRPSTLAGQFKQSLDKLMKILTNCQPYFIRCIKPNEYKKPMLFDRELC
LRQLRYSGMMETVQIRKSGFPIRYSLEDFSQRFCVLLPSTVRT-QLRDKFRQMTIRIADM
WLGTDKDWKVGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KGYQDTLLETQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAVSIQRVLRGYRH-RRQ

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AATALQAWWRGCYSRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILLGFERLQAIARGHLLVRQYQAMRHR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

MVQLQALCRG
YLVRQE

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVLVIQAHARGMAARRSF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRRK--------------------------
-----------------------------------ANAPLLIQAA-EKSQGALPDQKR-K
SIYDTVT--DTEMVEEVFGFLPAMIGGQEGQAPPRFEDLEAKIR--KLPEVDLDTVPMVE
E---PEEDVDGLADYTFPKFAATYFQKSASHTHIRRPLRYPLLYHEDEADCSAALAVWNV
ILRFMGDLPEPVLYARSN-QGS-SVMQQIHDTLGKAGGAQSLQQAGSAQ-----RPGHKD
KTT-KISSMKLKRSSRV---TGQVA----SQL-NTGEEAFEPSGPVTD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NFRPSSLARGWILLSLCLGCV--PP
SERF-MKYLLNFIGRGPAGYGPFCAERLRRTYTNGMRTEPPTWLELQAVKSKKHVPIQVI
MVTGDSLTV---TVDSASTSREI--CLHIARKQGLSDYLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPVST
KLIYRQVLHGVWS-GEYSFEKEEGLVELLARHCYVQLGAS--VGDKAIQELLPSCLPPKL
YRTKPPEKWTSLVTAAYAK-APYTQTQATPL-------------------------AVQ-
EQVVDA---AC-----------------------------------------LQWPLLFS
RLFEVTTLS-GPGL----------------------------------------------
----------------PKTP----------------------------------------
-------------------------------------------------------LVLAV
NWKGLYFLDQR-E--KMLLELSFPEIMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLTTLH-EDYEFLSPSSVAVAEL
VALFLEGLKERSVHAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DPTLL-PFKKGDLLVLTKKQGLLASE-NWTL
AQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYAIPTVTKPSVQLLSLLAMSPEKRRLAAQEGQPAQPPAVEQ-P
GEKPHTLEEFSYE-FFRAPDKGTVSRAVLPLARARGHLWAYSPEPLRQPLLKRV----HA
NVDL-------RDIACQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSLALQDS
SLQDEVYCQILKQL-THNSNRHSEDRGWQLLWLCTGLFPPSKALLPHAQKFIDTRRGK-L
LAPDCSRRVQRVLRAGPRKQPPHQVEVEAAEQNVSRICHKVYFPNSTNE--MLEVGSGTR
VRDVCDSIAARLQLASWEGCSLFIKVADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDRSQLASVAKILRELVPENLTRLMSPEEWRKS-ILPAYDKHRDKTVE
EAKVAFLRWLCRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPRTK--------
-----------------------------------------------DLLATHPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTMDRQRGSRAP
ALASP----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFMATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYYMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFAMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFEEFSQRFGALLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKLGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTMQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQAPQH-RF-------------
---------------------AQVA----SQL-NIGEETLEPDGLGAD-------QPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERSESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--VESKAVQELLPSCIPHRL
YRTKPPERWASLVTAACAK-APYAERQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQRLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGKLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNITPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLANVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

----------------------MVVLRKGDHVWLESFSNSEFSVPIGAVVKIS-DSGQIL
VEDDEGKEHWITARNISAVRPMHPTSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 597)

VEDMIRLGDLNEAGIVRNLLIRHQEHKIYTY
TGSILVAVNPYQVLPLYTVEQIQLYSNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGSGKTESTKLILQFLAAISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFSRSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNLEQKKMLNLGT
ASEYTYLTMGDCTSCESRNDAKEYAHIRSAMKILMFSDSEHWDISKLLAAILHLGNVEFE
AAVYENLDCSDVLDSSHFSVATKLLEVDSKELQNSLTNHSIIIRGESVSKPLSVAQAADG
RDAFVKAIYGHLFLWIVNKINAAIFNPPSQDPKSSRRSIGLLDIFGFENFNTNSFEQFCI
NFANEHLQQFFVRHVFKLEQEEYLAEHISWNHIDFTDNHQALEVISLKPMNIISLIDEES
KFPK--GSDTTLLNKINSQH----GKSKVYIPPRSVHD--TKFGINHFAGVVYYQSKGER
RAPPPPPRRLHRGHCPVAHS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------MSAFRLGDHVWLNPLSANKSSVAIGCIVKET-KPGKIL
LEDDEGKEHWIRAEDLDTLSPMHPISVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSHHMGELPPHVFAIANNCYFNLKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYSMLMGMSAEEKQLLSLGT
PSEYHYLTMGNCTSCEGLDDAKDYAHVRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMDTPAFPTVLKLLEVEYQVLRDCLIKHSIIIRGESVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINTAIFTPSAQDPKNVQRSIGLLDIFGFENFQKNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYLSENIAWDYIHYNDNRPTLDLLALKPMSIISLLDEES
HFPQ--GTDTTMLQKLNNVH----ANNKAYLQPRNIHD--ARFGITHFAGEVYYQTEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFKLESAETKLGHGTIIQAKTGS--QL-----
----FKS-TDPSKRPSTLASQFKKSLDQLMKILTSCQPYFIRCIKPNEYKKPLLFDRDLC
IRQLRYSGMMETVHIRKSGFPLRYTFQEFSQRFGVVLPSAVRL-QLRDKARQMTLHIAEM
WLGTDKEWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDNQDTLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAVNIQRVVRGYKW-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRAHYNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KQILLGFERLQAIARSQLLAKQYQTMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

MVQLQALFRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVVIQAHARGMAARRN

ENSGT00900000140810_6_Linker_6_7 (930, 1259)

FWQQKANGP----------------------
--------------------------------------LV-IPAEEQKSPSALPTRKQ-K
SIYDTIT--DTEMVEQVFGFLPSMIGGQEGPAPQRFEDLETE--TQKLPEVDLDAVPMVE
E---PEDDTDSLAEYTFPKFAATYFQKSASHTHIQQPLRYPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPVLFSRNSLRGG-SVMRQIHDTLGKENNTQSPQLHVST--QRPSRRDR--
-GSKDISSMKLKRSSRI---TGQVT----SQL-NIGEEAFEPDGPISD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIVGCAILRPN--LRDEIYCQ-ICKQLSE-NSKTSSLARGWILLSLCLGCF--PP
SERF-LKYLMNFIGQGPAGYSPFCAERLRRTYANGVRMEPPTWLELQAVKSKKHIPIHVI
LVTGESLTV---MVDSASTSWEV--CLHIAHKQGLSDYLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLARARGENER-----QAPWRIYFRKE--F-FTPWHDSQEDSVST
QLIYRQVLHGVWS-GEYSFEKEEELVQLLAQHCYVQLGAS--VGSEAVQELLPSCIPSKL
YRTKPPEQWASLVTAAHTK-ARYTQKQAKPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
QLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGIYFLDQK-E--KMLLELSFPEVMS---------LITNREAQ---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLVLSTLHAEEYEFMSPSSVAIAEL
VAMFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATDDTA----LL-PFKKGDLLILTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2325)

LYAIPVVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEPLPEEQ-P
KDKLHTLEEFSYKF-FRAPEKETVSRAMFPLARTRGHLWAHSSEPLRQPLLKRV----HA
NAEL-------RDLACQ-I-F--IA----ILRYMGDYPSRQAWT

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2430)

SVELTDQIFSPALQDS
ALQDEVYCQILKQL-THNTKRYSEERGWQLLWLCSGLFPPGKALLPHTQKFIDTRRKK-L
LAPDCSRRLQRILRTGPRKQPPHSVEVEAMEQNISRICHKIYFPNDTSE--MLEVGTNTR
VRDVCQSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLSVIPGKDTNA

PF00373 // ENSGT00900000140810_6_Domain_14 (2555, 2661)

DTILHYHQELPKYLRGFHKCSREDAI
HLASLIYKAQFNNDRSQLASIPKILRDLVPENLTRLMSSEEWRKN-ILLAYDKHKDKTVE
EAKVAFLQWICRWPTFGSAFFEVKQTSETSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMALGSLARGSRLLCETSLGYKMDDLLTS-----YVQQLLSTMNKQQGSQAP
AQADL----------------------------------

----------------------MSVFKLGDHVWLNPYSANKTSVAIGGIIKEM-KPGKIL
VEDDEGKEHWIQTKDLGTLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQRHKIYXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXFGNAKTIRNDNSSRFG
KYVDIYFNTSGAIEGARIKQFLLEKSRVCRQAPEERNFHIFYCMLLGMSVEEKELLGLRT
PSEYHYLTTGNCTSCEGLNDAKDYAHVRSALKILMFSDAENWDLSKLLAAILHLGNVEFM
PAVFENLDSSDVMETPAFPTVMKLLEVKHQALQDCLIKHSIIIRGEFVSRPLNIAQATDR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYHSESIAWDFIHYTDNRPILDLLALKPMSIISLLDEES
RFPQ--GTDITMVQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVHSSQNKFLKEIFKLESADTKLGHGTILRGKAGS--QF-----
----FKS-ADSSRQPATLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKAGFPLRYTFEQFSLRFGVLLPSAIRL-QLQDKFQEMTLRIAEM
WLGTNKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDNHDTLLEVQRSQAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

EKAAISIQRVLRGYKY-RKEF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAAWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILLGFERLQAITRSYLLARQYQAM

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RQRMIQLQALCRG
YLVRLQI

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVIIQAHARGMAARRNFQRQKANGL----------------------
---------------------------------------LVIPTEEQKDQSALHTRKR-K
SIYDTIT--DTEMVEQVFGFLPSMIGGQEGQAPPRFEDLETK--TQKLPEVDLDTVPMVE
E---PKEDVDGLAEYTFPKFAATYFQKSASHTHIRRLLPYPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPVLFARNNLCGS-SVMQKIHDTVGSKSSTQSPQHSV--------------
--------------------SAQVA----SQL-SVGEEAFEPDGSISD-------RPMSN
LEKVHFIVIYAILRPS--LXXXXXXX-XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXPTGVRTEPPTL-LLQAVKSKKHIPIHVI
LVTGESLTV---TIDSASISQEV--CLHIARKLGLTDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIGQCEQLTRERGESER-----QSPWRLYFRKE--F-FTPWHDSSEDAVST
ELIYRQVLHGVWS-SEYNFEKXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-ALYTQKQATPR-------------------------TVQ-
EQVVDA---AR-----------------------------------------LRWPLLFS
RLFEVTTLS-GFTL----------------------------------------------
----------------S-PLARPPTAQDSGPKGEDALRTLFPRG-HESD---HQQVGDP-
-------WEGA-QISLSSEGDPRPP----VPGSTAPLVLH----LQIMHCPLSLSLKKS-
TKKGHVSLQPL-V--CICL-GSFSSL-----VMKVQTIWEEVKRQGLARPDP---HPHGS
LLSSPQNASKPFGKAPQCIMTYNWYQTCREHLATAPSSHSITQSADEKLRQAEAGL---Q
SWH------LISPPMFF-AVSLGSGTLATSLSAQGRPEVAPPTA--SEGHTVELGLTA-Q
ILALQWQSCFLVR--RRPLITSP--FVSREAQGGQRLVLSTLHEEEYEFASPSSVAIAKL
VATFLEGLKERS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2180)

VFAMALQDRKATD----DVTLL-PFKKGDLLILTKKQGLLTSE-NWIQ
GQNDRTGKTGLVLTTCLYA

ENSGT00900000140810_6_Linker_10_12 (2180, 2323)

IPTVTKPSAQLLSLLAMSPEKRKLAAQERRQAESPLEDQ-A
IEKLHTLEEFSYGF-FRAPEKETVNRAMFPLARSRGHLWAHSPEPLRQPLLKRV----HA
NAEL-------RDVACQ-IFT--TP----ILRYMGDYPSRQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

WTSVELTDQIFSLALQDT
ALQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-P
LAPDCSRRIQRVLRTGPRKQPPHQLEVEATEQNISRICHKIYFPNDTSE--MLEVGANTR
VREVCESIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKSKPQK
E----GAP-MMLPYEVYFMRKLWLSVAPGKDMNADTILHYHQELPKYLRGFHKCSREDAV
HLAGLIFKAQFDNDQSQLASIPKILRELVPENLTRLMSSEEWKKS-ILLACDKHRDKTAE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPAIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKIAS
WSSGSTYFHMALGSLGRGNRLLCETSLGYKMDDLLTS-----YVQQLMSTVNKQRSARVP
ALADP----------------------------------

--------------------VSVFGELIGDHVWLDPPSTDKSNVAIGGIIKET-KPGKIL
VEDDEGKEHWIQAEDLGALSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQLLPLYTLEQVQLYYGRHVGELPPHVFAIANTCYFNLRKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVHNDNSSRFG
KYIDIYINPSGVIEGARIEQFLLEKSRVCHQALEERNYHIFYCMLMGMSEAEKKLLDLGT
PSEYHYLTMGNCTTVKGLNDTMDYAHIRSAMKILLFSDSENWDISKLLAAILHLGNIEFM
AAIFENLDSSEVMETPTFPIVVKLLEVEHQPLRDCLIKHTILIRGEYVTRPLNIGQASDR
RDAFVKGIYGHLFLWIVKKINAAVFTPPAQDPKIVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYRSENLTWDYIHYTNNQPTLDLLALKPMSVISLLDEES
RFPK--GTDLTMLQKLNNVH----TNNKAFLKPKSIHD--ARFGIAHFAGEVYYQTKGFL
EKNRDV---LSTDILTLVHSSKNKFLRQIFNLESAETKLGHGTIRQAKTGS--QL-----
----FKQSTDSAKQSPTLAGQFKQSLEQLMKILTRCQPCFVRCIKPNEYKKPLLFNRELC
LRQLRYSGMMETVRIRKSGFPVRYTFEEFTQRFWVLLPTTQRT-QV-YNFRQMTLSIADL
CVESDKAWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEIQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAAVRIQRVLRGYKH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 842)

FLRQKQ-
-

PF00612 // ENSGT00900000140810_6_Domain_4 (842, 862)

-AAVTLQARWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KMILVGFERLQAIAQSHILARQFQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQARCRG
YLVRKQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHTRGMAARRCF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QRQK--------------------------
-----------------------------------ASGPVIIPAEEQKNQSALPTKKRSK
SIYDTVT--DTEMVEKVFGFLPSMLGGQEGQAPARFEDLETKTP--KLPEIDLDTVPMVE
E---PKEDMDDLAEYSFHKFAVTYFQKSASHTHIRRLLRYPLLYHDDNTDYSAALAVWTI
ILRFMGDLPEPVLYAKNSLRGS-PVMPQIHDRLGQEGMAQGAQHTGPVQ-----------
-----------------------VA----SQL-STGEEAFDPDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NPKVSSQARGWILLSLCLGCF--PP
SERF-LKFLLNFIGQGPAGYGPFCAERLRRTCANGVRTEPPTWLELQAVKSKKHIPIQVI
LVTGQNLTV---TVDSASTSWEV--CLHIAQQQDLIDHLGFSL-----QVAVYDKFWSL-
GSGKDHLMDAVARCEQLTQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQILHGVWS-GEYSFEREEDLVELLARHCHVQLGAS--SGTEAVRDLLPSCIPPKL
YKTKPPEKWASLVTAAQAK-ALYTQTGATAL-------------------------AVR-
QQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAI
NWKGLHFLDQR-G--RMLLELFFPEVTS---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------SRGGQRLLLSTLHAEEYEFTTPSSVAVAEL
VALFLEGLKERSVFAMALQDRKTTD----DVTLL-PFKKGDLLVLTKKQGLLVSE-NWAL
GQNDRTGKTGLVPMACLYTIPTVIKPSSQLLSLLAMSPERRKLAAQEGLPSDLLPEEQ-P
REKPHTLEEFSY-KFFRAPEKETVSRAMMPLARTRGHLWSYSMEPLRQPLLKHV----HD
KADL-------RDVA---FAPIL--------KYTGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSLALQEP
SLQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRKK-L
LALDCSRRIQRVLRTGPRKQPPHQVEVEAAEKNVSRVCHKIYFPNDTSE--MLEVGTNKR
VREVCELIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GTL-VTLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFYKCSREDAI
HLAGLIYKAQFDNDRSQLASVPKILRDLVPENLTRLMSSEEWRKS-LLLEFDKHQDKTVQ
EAKVDFLKWICRWPTFGSAFFEVKQASEPSYPDIVLVAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSVVNKHRGSRAA
PLATP----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 637)

VDDMIRLGDLNQAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFMATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFAMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDLTMLQKLNSVH----TNNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRQAKAGN--HL-----
----FK------------------------------------------------------
---------------------------------------------LRGKFRQMTLGIADM
WLPTDKDWKVGKTKIFLKDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTVQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRR--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQALQH-RF-------------
---------------------AQVA----SQL-NIGEETLEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CMHIAQKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVQLLARHCYVQLGAS--AESKAVQELLPSCIPHRL
YRTKPPDRWASLVTAACAK-APYAERQATPL-------------------------AVR-
EQVVDA---AC-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLTMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQARPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQAEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNITPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHVVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

----------------------LLSALQGDHVWLNPTSANKTSVAIGGIIKET-KPDKIL
VEDDEGKEHWIRAEDFGTLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLNEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNRHMGELPPHVFAIANNCYFNMKRNKRDQCCVIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMSTEEKQLLGLGT
PSEYRYLTMGNCTSCEGLNDAKDYAHIRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMETPAFPTAMKLLEVKHEALRDCLIKHSIIVRGEFVTMPLNLAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQLFVQHVFTMEQEEYRSEGIAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
HFPQ--GTDITMLQKLNSVH----ANNKAFLQPRNIYD--ARFGIAHFAGKVYYQAEGFL
EKNRDV---LSTDILALVHSSENKFLREIFNLEAPG------------------------
--------AHSSKRPPTLAGQFKRSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYAFDEFARRFRVLLPSAERT-QLRDKFRQMTLRIAEM
WLGTDKDWKVGKNKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KESHDVLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

KAAVSIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTIQAGWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILLGFERLQAIARSHQLAKQYQATRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 912)

VQAKK

PF00612 // ENSGT00900000140810_6_Domain_6 (912, 931)

RAVVVIQAHARGMAARRDF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

QRQKANVGQRNTKRR-LQVSAQERLK---G
RAQGDRARAR----A---SKRADPQTR-QQQ-ASPAGPLA-IPAEEQKSRSALPTRKR-K
SIYDTIT--DTEMVEQVFGFLPSMIGGQESQASPRFEDLEAR--SQQLPEVDLDTVPMVE
E---PEEDLDDLAEYTFPKFAVTYFQKSASHTHLRRPLRYPLLYHEDSADCSAALAVWCI
ILRFMGDLPEPVLFARNSLRGGSSVMQQIHDTLGRGNSTPDQQMLRAGGEALRTPPHVKD
KGIKGISSMKLKRSSRI---TGQVA----SQL-NIGEEAFEPDGPISE-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIVGCAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIGHGPASYGPFCAERLRRTYANGVRTEPPTWLELQAVKSKKRIPIHVI
LVTGERLTV---MVDSASTSREV--CLHIAHKQGLNDHLGFSL-----QVTVYDKFWSL-
GSGRDHVMDAIAQCEQLAWERGEKER-----QAPWRIYFRKE--F-FTPWHDSREDPVST
QLIYRQVLLGILS-GEYSFEKEEELVELLARHCYVQLGAS--PGSEAVQELLPGCVPSKL
YRTKSPEKWASLVTAAHTK-AQYTQKRATPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
QLFEVTPLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQR-E--KMLLELSFPEIMS---------LITNSGPR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------QAAVSVLLLSTLHKEEYEFLSPSSVAIAEL
VALFLEGLKERSVFAMALQDRKATGGC--DVTLL-PFKKGDLLILTKKQGLLASE-NWIL
GQNDRTGKTGLVPMAYLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQPPELSPDEQ-P
KE-PHTLEEFSYEF-FRAPEKETISRAVFPMGRTRGHLWAHSVEPLRQPLLKRV----HA
SAELCD-------V---AS-A--AP----ILRYMGDYPSRQAWTS

PF00784 // ENSGT00900000140810_6_Domain_12 (2326, 2430)

LELSDQIFSLALQDP
ALQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRKK-L
LAPDCSRRLQRVLRTGPRKQPPHQVEVEAMEQNVSRICHKIYFPNDTSE--MLEVGSNTR
VRDVCNSISTTLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRHVSDWVKRNKPHR
E----GAA-VTLPYQVYFMRKLWLHVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFGNDRAHLASIPKILRELVPENLTRLMSSEEWRKS-ILLACEQHRDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKIAS
WSSGSTYFHMVLGTLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTVNKQRGSQAP
ALAEL----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEA-KPGKVS
VEDGEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 667)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDITKLLATILHLGNVGFM
ASVFENLDASDVMEMPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPRNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSIH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAE---
------------------------------------------------------------
------S-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRM-QLRGKFRQMTLGITDV
WLRTDKDWKVGKTKIFLKDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

RQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-R
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQASPRFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSSQQGS-SVMRQIHDTLGREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NIGEEALEPNGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREM--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIAQCEQMAQEKGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQKQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSIFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DTTLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPMAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPCPEEP-P
KEKLHTLEEFSYE-FFRAPEKDMVSMAMLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSE--VLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VMLPYQVYFMRKLWLNISPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQRGSKAP
ALAST----------------------------------

---------------------MSAVFRLGDHVWLNPPSTDKTCVAIGGIVKDT-KLGKIL
IEDDEGKEHWIQAEDLGTLSLMHPNSSQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMICLGDLNEAGMVHNLLIRYQQNKIYTY
TGSILVAVNPFQMLPLYTLEQVQLYYSHHLGELPPHVFAIANSCYFNMKKNKRDQSCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIESARIEHFLLEKSRVCRQAAEERNYHIFYSMLMGMNPEEKKLLGLGM
PAEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILQFSDSENWDTSKLLAAILHLGNVEFT
AAVFENLDSSDVMDTPAFPLAMKLLEVQHKALRDCLIKHTIPILGEYVSRPLNIAQAVDR
RDAFVKGIYGHLFLWIIKKINAAIFTPPSQDPKNIRRAIGLLDIFGFENFQSNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYHSENISWNYIHYTDNRPTLDLLGLKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSVH----ANNKAFVKPKNIHD--TRFGIIHFAGEVHYQVEGFL
EKNRDM---LSTDILALVHSSKNKFLREIFNLESPQAKLGHGTINQAKARS--QF-----
----LKQ-ADSTKRPSTLGGQFKQSLDQLMRLLAHCQPYFVRCIKPNEYKKPLLFNRELC
IQQLRYSGMMETVHIRKSGFPIRYTFEEFSKRFHMLLPGPERT-ELRDKFRQMTLCIVDK
CLGTNKDWKVGRTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTMLEIQRGQALNG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVRIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRK

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RQ-
--AAVTLQARWRGHHQRKN

ENSGT00900000140810_6_Linker_4_5 (860, 889)

F-ELILVGFQRLQAIALSHLLMKQFQTMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QKMVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQQK--------------------------
-----------------------------------PNGPPVILAKEQKGQSAALERKR-K
SIYDTIT--DTEMVEKVFGFLPDMIGGQEGPAPMRFEDLEVKTQ--KLPEIDLDTVPMME
I---PEEDVDGLSEYTFPKFAATYFQKSASHTHIRKPLQYPLLYHENDTDHSVALAVWTI
ILRFMGDLPEPVFYARNSLSGS-SVMRQIHDRLDKDSI-KGSQHNGP-------------
---------------------TQVA----NQL-NVGEEILD----TSD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKMSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFICRGPPSYGPFCTERLQRTFANGVRTEPPTWLELQAVKSKKHIPIQVI
MATGESLTI---TVDSASTSQEI--CLHIAQKQGLTDHLGFSL-----QVAVYDKFWTL-
GSSRDHVMDAVAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHNSQEDSVST
ELIYRQVLHGVWS-GEYRFEKEEELVELLACHCYMKLGAS--VRSEAVQELLPSCVPSKL
YRTKTPEKWVNLINAAHAK-ALYTQARATPL-------------------------QVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTIS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGIYFLDQR-E--KILLELSFPEVMG---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGERKLLLSTLH-EEYEFVSPSSVAIAEL
VALFLGGLKERSVFAMALQDRKATD----DTTLL-PFKKGDLLILTKKQGLLVSE-TWAQ
GQNDRTGKTGMVPMACLYAIPTLTKPSTQLLSLLAMSPEKRKVAAQEGQASEPPSEEQ-P
TETPYTLEEFSYQ-FFRAPEKETVSRATMPLARSRNPLWAYSPEPLRQPLLKHV----YD
KANL-------RDIACQIFLAIL--------KYTGDYPSRQAWQSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2428)

ELTDQIFSPALQDP
ALQDELYCQILKQL-THNSIRFSEERAWQLLWLCTGLFPPGKVLLPHAQKFIDSRRKK-L
LAPDCSRRLQRVLRIGPRKQPPHHMEVKTAEQNVSRIRHQIYLPNATTE--TMEVSSSSR
VRDVCEGIATRLQLASWEGCSLFIKITDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAS-VTLPYQVLFMRKLWFSVTPGKDMNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDRSQLTSIPKILKELVPQNLTRLMSSEEWKKS-LLLECDKHKDKTVA
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPITKISS
WSSGNTYFHMTLGSLGQSSRLLCETSMGYKMDDLLTS-----YVQQLLSVVNKQRGSLVP
ALANP----------------------------------

----------------------------GDHVWLDSPSTNKIGVAIGGVIKET-KPGKLL
VEDDEGKEHWIRMEELGVLSPMHPSSVEG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYNRHVGELPPHVFAIANSCYFNMKKNKQDQSCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXGNCTSCEGLDDAKDYAHVRSAMKILLFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMDTPGFPLVMKLLEVQHQALRDCLIKHTILIRGEYVSRPLNIAQAADR
RDTFAKAIYGHLFLWVVKKINTAIYPPPSQDPKHVRRVIGLLDIFGFENFQSNSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYRIETITWDHIQYTDNRPTLDLLALKPMSVISLLDEES
HLPQ--GTDLTMLQKLNSIH----ANDKAFLQPKNIHD--ARFGIAHFAGEVYYQVEXXX
XXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX-----
----XXX-XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXRYAFEEFSQRFRVLLPSAECL-KLKDKFRQMTLRIIEA
YLEGDKDWKVGKTKIFLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XKEFLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--SAVVLQAAWRGYCGRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILLGFERLQAIARSHLLVRQFQAL

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RQKMVQLQARCRG
YLVRQQV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KRAVVIIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

QRQK--------------------------
-------------------------------------GLVVTPTGKPKNRSPSPAKKR-T
SIYDTVT--DTEMVEQLFGFLPAMIGGQEGPAPRRFEDLEPKTQ--KLPEIDLDAVPMLE
E---PKEDEDGLAEYSFPKFAATYFQKSASHTHIQRPLRYPLLYHESDTDCQAALAVWTI
ILRFMGDLPEPILYARSSLHGG-SMMRQIHMLRGEHLAL---------------------
--------------------PPSVA----SQL-NIGEDALDLDGPISD-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVHVIVAYAILKPD--LRDEIYCQ-ICKQLSG-NAKKSSVARGWILLSLCLGCF--PP
SERF-MKYLLNFIRQGPVGYGPFCAERLRRTCANGVRMEPPTYLELQAVKSKKHIPINVI
LINGESLTV---MVDSASTSREI--CQHIAQKQDLRDHLGFSL-----QVAVYDKFWSL-
GCGRDHLMDAVAQCEQLAQEKGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
KLIYRQVLHGVCS-GEYGFEKEEELVELLARHCHVQLGPS--AGSKAIQELLPGCVPLRL
YRTKSPEKWASLVMAAQAK---SPQVQDTPQ-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFQVIPFS-GSHL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGLCFLDQR-E--KILLELSFPEVMS---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLTTLR-DDYEFVSPSCVAIAEL
VALFLEGLKERSV

PF07653 // ENSGT00900000140810_6_Domain_10 (2114, 2180)

FAMALQDRKATE----DATLL-SFKKGDLLILTKKQELLASE-SWTL
GQNDRTGKTGLMPTNCLYV

ENSGT00900000140810_6_Linker_10_12 (2180, 2323)

IPTLTKPSAQLLSLLAMSPEKRKLAARETGRMEPLAEEP-P
QEMLHTLEEFSYT-SFRAPEKETVGRALPSLARMRGHLWAYSAEPLRQPLLKRVHNN---
-ARA-------TLVPLSLT---RAP----ILKYMGDYPSRQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

WSTLELTDQIFSGL--QE
VLQDEVYCQILKQL-THNANRYSEERGWQLLWLCTGLFPPGKALLPHVQKFLDTRRTK-P
LAPDCSRRLQRVLRTGPRKQPPHQVEVEAAGQKLSRMYHNVFFPNDTSEXXXXXX--XXX
XXXXXXXXXXKLQFSSWEGCSLFIKITDK---VVSLKEADFFFDSLRQMSDWAKKNRPQK
E----GAL-VTIPYQVYFMRKLWINVVPGKDMNADNILHYHQELPKYLRGFHKCSQEDAV
HLAGLIYKAQFDKDQSQLASVPKILKELVPMNFTRIMSTEEWRKS-LLLAYNMHKSKTVQ
EAKVAFLKWISRWPTFGSAFFEVKXXXXXXYPDIILIAINRRGILLIHPKTK--------
-----------------------------------------------ELLTTYPFNKISS
WSSGSTYFHMVLGSLGRGNRLLCETSLGYKMDDLLTS-----YVQQLTSAMNRQRAPGTS
ALGSP----------------------------------

----------------------------G

PF00063 // ENSGT00900000140810_6_Domain_0 (30, 798)

DHVWLNLSS---SRVAIGGIIKET-KPGKIL
IEDDEGK-----------------------------------------------------
------------------------------------------------------------
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTVRNDNSSRFG
KYIDIYFNASGVIEGARIEQFLLEKSRVCRQAPDERNYHIFYSMLXXXXXXXXXXXXXXX
XXXXXXXXXGNCTSCRELNDAKDYAHVRSAMKILMFSDSENWDLSKLLAAILHLGNVKFM
AAVFENLDSSDVMDMPAFTIAMKLLEVQHQDLRDCLVKHSMIVRGEFVVKPLNITQAADR
RDAFVKGIYGHLFLWIVKKINSAIFKPPDKDPKNVRRAIGLLDIFGFENFQKNSFEQLCI
NFANEHLQQFFVHHVFTMEQEEYRSENIKWNYIEYIDNRPTLELLALKPMSIISLMDEES
RFPQVCGTDITMLQKLNNVH----ANHKAFLKPKNIHD--TRFGIAHFAGNVYYETEGFL
EKNRDV---LSKDILTLVYSSKNKFLKEIFNLESAETKLGNTTIFKANSGS--QI-----
----FKS-PDSSKQRSTLAGQFKQSLDQLMKILNNCQPYFIRCIKPNEYKKPLLFDRELC
LQQLRYSGMMETVHIRRSGFPIRYTFEEFSNRFRVLLPTPLSR-QLRDRHRQMAQRIAEM
WLGTDKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDNQDTLLEIHRTQAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

DRAAISIQRVLRGYKY-RQQF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AARTIQAMWRGHISRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

QMIFLGFERLQAIARSHLLRKQYLDT

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RKRIIQLQARCRG
YLVRQQV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

EAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KRAVVVIQAHTRGMAARRKF

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

QQQR--------------------------
-----------------------------------TNGPLGIPAKAPKKKTDPPSKKR-A
SIYDTIN--DTEMVERVFGFLPSMMG-QNGQISPVLEDLEAKSH--KLPEIDLDTVPMVE
ETEEPDDEADSLSQYSFSKFAATYFQKSATHTHIRKALRSPLLYHEDDADCSAALAVWSI
ILRFMGDLPEPMLFARNTMRGS-SVMRQIHDTLSKGSSTRPEQHDAL-------------
---------------------AQVT----SQL-SVGEEAFDPDRPISE-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVQFIVSFAILRPN--LRDEIYCQ-ICKQLTQ-NSKTSSLARGWILLSLCLGCF--QP
SQRF-MKYLQNFISNGPPTYGPFCAERLRRTVANGTRMEPPTWQELQXXXXXXXXXXXXX
XXXXXXXXX---XXXXXXXXXXX--XXXXXXXXXXXXXXXXXX-----XXXXXXXXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXX--X-XXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXEEELVQLLAQHCYVQLGAS--PRKEAVQELLPSCIPSKL
YRTKPLEKWVSLITAALAKXXXXXXXXXXXX-------------------------XXX-
XXXXXX------------------------------------------------------
------------XX----------------------------------------------
----------------XXXX----------------------------------------
-------------------------------------------------------XXXX-
XXXXXXXXX---X--XXXXXXXXXXXXX---------XXXXXX-X---------------
------------------------------------------------------------
------------------------------------------------------------
------XXXXXXXXXXXXXXXXX--XXXXEARGGQRLLMSTLHEEEYEFLAPACVAIAEL
VALFLEGLKERS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2180)

VFTMALQDRSNAD----DPTLL-PFKKGDLLILNKRQGLLASE-KWTQ
GQNDRTGKSGLVPLACLYVIPTITKPPTQQLSLLAMSPEKRKLAAQEVPTRAT------L
SEEKHTLEEFSYE-YFRTPEKESVSRAMLPAARARCHLWAHSSEPLRQPLLKRVNPNXXX
XXXXXXXXXXXXXXXXXXXXX----------X-XXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXX-XXXXXX-XX-XXXXXXXXX--
-XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMPEVNSGTR
VREVCENIAKRLKLSSWEGCSLFIKIADK---VISVNEGEFFFDALRNISDWVKKNKPQK
E----GAS-VALPYQVFFMRKLWLNVTPGKDVNADTILHYHQELPKYLRGFHKCSREDAL
QLAGLIYQAQFGKDRSHLASIPKILRELVPENLTRLMSTEEWKKN-ILLACDKHKDKTVE
EAKVAFLKLISRWHTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAN
WSSGSTYFHMSLGGLGRSSRLLCESL----------------------------------
---------------------------------------

----------------------MSGLRLGDHVWLNFTSADKTSVPIGGVIKET-KPGKIL
VEDDDYKEHWIRAEDLGTLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMILLGDLNEAGMVHNLLIRYRQHKIYTY
TGSILVAVNPYQALPLYTVEQVQLYYKRHVGELPPHIFAIANNCYFNMKQHKMDQCCIIS
GESGAGKTETTKLILQFLATISSQHSWIEQQVLE---ANPILEXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAPEERNYHIFYGMLMGMSAEEKDLLCLGA
PSEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILMFSDSENWDLSKLLAAILHLGNVEFM
ATVFENLDSSDVMETPAFPTVMKLLEVKDQELRDCLIKHSIIIRGEFVTRPLNISQAADR
RDAFVKGIYGHLFLWILKKINAAIFTPPAQDPKNVRRTIGLLDIFGFENFQKNSFEQLCI
NLANEHLQQLFVQHVFTMEQEEYRTECIPWDYICYNDNLPMLDLLALKPLSIISLLDEES
RFPQ--GTDITLLQKLKNIH----ANNKVFLQPKNIHD--ARFGIAHFAGEVYYQAEXXX
XXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX-----
----XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLFNRELC
IWQLRYSGMMETVHIRKSGFPIRYSFEEFSQRFTVLLPSAARR-ELRGKFRQMTLRIAES
RLGTDKDWKMGKTKIFLKXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXKEFLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGNYSRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILLGFERLQAIARSHLLAKQYQDM

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RQRMVQLQALCRG
YLVRQQV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAYARGAAVRRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

RRQKANES----------------------
---------------------------------------LVIPAAEQKSPSAVPSRKR-K
SIYDTVT--DTEMVEQVFGFLPSLMGGPEGQATPHVKDLEER--TQKLPEVDLDTVPMME
E---AEEDADGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEEDADCSAALAVWNI
ILRFMGDIPEPVLFARNTLRGG-SVMPQTHDTPGRESGAQPPAHGGS-------------
---------------------TQVA----SQL-NIREEAFDPDEPISD-------GP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVQFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NYKTSSLARGWILLGLCLGCF--PP
SERF-MKYLLNFIGQGPVGYGPFCAERLRRTCANGVRTEPPSWLELQAVKSKKRVPIHVT
LATGESLTV---SVDSASTSREV--CLHIAHKQGLSDHVGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLARERGESER-----QTPWRLYFRKE--F-FTPWHDSREDPVST
RLIYHQVLHGVRS-GEYSFEKEKELVQLLAQCCAVQLGAS--VRSQAVQELLPSCVPPKL
YRTKPPEKWASLVTAALAE-APYTQKQTTPL-------------------------AVQ-
EQVVNT---AC-----------------------------------------LKWPLLFS
RLFEVTTLS-GFTL----------------------------------------------
----------------LSPSARPPTAQDSGPEGEGAPRTLFPGG-HKPD---HQQVGAL-
-------REDL-----SP-QGTHLP----VPGSTVH----------ITHCLLRLPLERSP
PWKGHISLQPP-G--CTFTYGSFPSHGAGEALTRVPAVWEGSEGQGCPGGTSDALSLCSP
RLSPSEKASMPFGKATARCGHCGQYQVCRALA-TTPVSPPSTQSAINKRKHIEAGLPSSP
GWR------SISAPPSL-RW---PSTLATTLPARSPHRRAPPLRLEPMGHTAGPGTGADL
LLALPWLLGFFIGWSRPLVTLPP--FPLREAQGGQRLVLLTLHEEEFQFRSPSSVAIAEL
VAMFLEGLKEKS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2180)

VFAMALQDRKATE----DAALL-PFKKGDLLILTEKQGLLTSE-NWTL
AQNDRTKKTGLVPTACVYT

ENSGT00900000140810_6_Linker_10_12 (2180, 2323)

IPTVTKPSAELLSLLAMPPEKRKLAAQEGRPAEPAPEEQ-P
EEKLHTLEEFSYEF-FRVPEKETVSRAVLPLARPRGRLWAHSAEPLRQPLLRRV----HA
DAEL-------RDVACR-IFT--AP----VLRYMGDYPSRKA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2416)

WTSLELTDQIFSAALQEA
ALQDEVYCQILKQL-THNTNRHSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-V
LAPDCSRRIQRVLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--MVQVGTNTR
VREVCDSIAARLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVADWVKKNKPQK
E----GAA-VTLSYQVYFMRKLWLSVAPGRDVKADTILHYHQELPKYLRGFHKCSQEDAV
HLAGLIYKAQFGNDRSQLASMPKVLRELVPENLTRLMSSEEWKKR-ILLACDKHRDMTVE
ETKVAFLKI-C-QPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTVNKQREPRTS
VPASP----------------------------------

----------------------MSVFRLGDHVWLDPPSSSKTGVAIGGIVKET-KLGKTL
IEDDEGKEHWVHAEDLSTLRPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGVVHNLLIRYQQHKIYTY
TGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLMGMSPEEKQMLSLGM
PSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFM
AAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQATDR
RDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEES
RFPQ--GTDVTMLQKLNSIH----ANNKSFLSPRSIHD--TRFGIAHFAGDVYYQAEGFL
EKNRDV---LSTDILILIHSSKNKFLKEIFNVDSSQTKLGHGTICQVK--AGSQL-----
----FKS-SDSIKRPVTLASQFKQSLDQLMRILTNCQPYFVRCIKPNEYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERM-QFQNKPRQMTLHIADL
CLGTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTVLEIRRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAIRIQRVLRGHKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAGWRGYSQRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILVGFERLQAIARSHLLMRQFQAMR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRIVQLQARCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 930)

RRAVVIIQAHARGMVVRKS

ENSGT00900000140810_6_Linker_6_7 (930, 1264)

YWQQK--------------------------
-----------------------------------STGPQVILAKEPKAQVAVHERKR-K
SIYDTVT--DTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ--KLHEVDLDTVPMMA
M---PEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWII
ILRFMGDLPEPVVYGRNSLTGS-SVMRQIHDKLGKDSVTQ---HNRS-------------
---------------------SQVA----SQL-NFGEEAFKFDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAIMRPG--LRDEIYCQ-ICKQLSE-NYKTSSRARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGRSLTI---SVDSASTSREI--CQHVAQKQGLRDNLGFSL-----QVAVYDKFWSL-
GSGCDHLMDAVAQCEQLARERGESQR-----QAPWRIYFRKE--F-FTPWHDSQEDPVST
ELIYHQVLRGVWS-GEYNFEKEEELVELLARHCYVQLGAT--VKSNAVQELLPSCVPSKL
YRTKSPEKWASLVTAAHAK-AQYTQSKATPL-------------------------AVR-
EQTVEA---AR-----------------------------------------LLWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAI
NWKGMYFLDQK-E--RTLLGLSFAEVMG---------LVANRD-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGKKLLLATLQ-EEYEFVSPSSVAIAEM
VALFLGGLKERSVFAMALQDRRATD----DITLL-PFKKGDLLILTKKQGLLASE-NWAL
GQNDRTGKTGLVPTACLYTIPSVTKPSTQLLSLLAMSPEKRKLAAQEVRALEPPLEDQ-L
TESPYTLEEFSYQ-FFRAPEKETISRAAMPMARSRGHLWAYSPEPLRQPLLKSV----HD
KAKL-------RDAACQIFLAIL--------KYTGDYPSRQSWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQMFSLALQDP
ALQDELYCQILKQL-THNSIRFSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKK-P
LALDCSRRLHRVLRVGPRKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSK--SMEVGSSSR
VRDLCEGIGTRLQLASWDGCSLFIKITDK---VISLKEGDFFFDSLRQVSDWVKKNRPQK
E----GAS-VTLPYQVFFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLGGLICKIQFGSDSSQLASVSKVLKELVPQNLTRLMSSEEWKKS-LLLECDKNKRKTVA
EAKVEFLKYMYRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIHPKTK--------
-----------------------------------------------ELLNTYPFTKISS
WSSGNTYFHMALGSLGQGSRLLCETSLGYKMDDLLTS-----YVQQLLNTVNKQRGFRAP
APANP----------------------------------

----------------------------GDHVWLEPPSTHKTGVAIGSIIKET-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEHVQLYYSRHMGELPPHVFAIANNCYFNVKRNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTVGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDLTKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFESNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQVCGTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGVAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAVRM-QLRGKFRQMTLGITDL
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1260)

QQRK--------------------------
-----------------------------------ANAPLIIPAEGQKSQGALPTKKR-R
SIYDTVT--DTEMVEK-VGFLPAMIGGQEGQAPPRFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSRQQGS-SVMRQIHDTLDREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NTGEEALEPDDLGAD-------RPMS

PF00784 // ENSGT00900000140810_6_Domain_7 (1260, 1370)

N
LEKVHFVVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKRIPIQVI
LATGESLTV---PVDSASTSQEM--CVHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQRQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LAT--------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------NEFVSPSSVAIAEL
VALLLEGVKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2326)

LYTIPTVTKPSAQLLSLLA-------------------------
-----------------------------------MHLWAYSSEPLRQPLLKLVHANRGA
AP----------APCSLTATPIL--------RYMGDYPSRQAWPT

PF00784 // ENSGT00900000140810_6_Domain_12 (2326, 2430)

LELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAADCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRICHKVYFPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNISPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFDNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
ETKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
------------------------------------DL-----------LTTYPFTKISS
WSSGSTYFHIALGSLGRGSRLLCETSLGYKMDDLLAS-----YVQQLLSAMNKQRGSKAP
ALAST----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEA-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRM-QLQGKLRQMTLGITDV
WLRTDKDWKAGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

RDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQKVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQPLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-R
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQ--KLLEVDLDTVPMAE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNV
ILRFMGDLPEPVLYARSSQQGS-SVMRQIHDTLGREHGAQVPQHSRS-------------
---------------------AQVA----SQL-NIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREM--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHMMDAIARCEQMAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLRGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHKL
YRTKPPDRWASLVTAACAK-APYTQKQVTPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQQ-E--KMLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSIFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DTTLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPMAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEP-P
KEKLHTLEEFSYE-FFRAPEKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKR----VHA
NVDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKISDK---VISQKEGDFFFDSLREVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNISPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQRGSKAP
ALAST----------------------------------

----------------------CLPLKKGDHVWLNPTPADKTRVAIGGIIKET-KPGKIL
VEDDEGKEHWIQAEDLGTLSSMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTVEQVQLYYRHHVGELPPHIFAIANSCYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNASGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMSAEEKKLLCLGT
PSEYHYLTMGNCTSCEGRNDAKDYAHVRSAMKILMFSDSENWDLSKLLATILHLGNVEFM
AAVFENLDSSDVMETPAFPTVMKLLEVKDQALRDCLIKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVQRTIGLLDIFGFENFQKNSFEQLCI
NLANEHLQQLFVQHVFTVEQEEYRAESIAWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDTTLLQKLKSVH----ANNKGFLQPKNIHD--AQFGIAHFAGEVHYHVEGFL
EKNRDV---LNRDILALVHSSQNKFLREIFGLES--------------------------
-----ES-ADSSKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNDYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYSFEEFSQRFRVLLPSAVRT-ELRNKFRQMTLRIAER
WLGTDKEWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KENQDTLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

EAAIRIQRVLRGYTH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGHYSQQNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILLGFERLQAIARSHLLAKQYQALRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVRLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

RQRKANVGGHCPLGQ-MKEGMQKEWA-A-T
KAQETRVRSP----EHSTGTVAR----------ARKSAEP-QTSEEQKSPSAVPKRKR-K
SIYDTIT--DTEMVEQVFGFLPSLTGGQDSPATPDIEDLKEM--TQKLPEVDLDTVPMME
E---PEDD---LAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDYSAALAIWSI
ILRFMGDLPEPVLFTRNTLRGG-SVMRQIHDALGKEGSTQPPQHSRSA--QLTTSHQPPS
APKHQACHRKLKRSSWV---TGQVA----NQL-NIGEEAFEEDSPLSD-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVQFIVGYAILRPD--LRDEIYCQ-ICKQLSE-NYKTSSLARGWILLGLCLGCF--PP
SERF-LKYLLNFIGQGPVGYGPFCAERLRRTCANGVRTEPPSWLELQAVKSKKHIPIHIS
LATGESLMV---MVDSASTSREV--CLHIARKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDALAQCEQLARERGESER-----QAPWRIYFRKE--F-FTPWHDSQEDPVST
HLIYRQVLHGVWL-GEYPFEKEEELVELLAQHCYVQLGAS--AGSQAIRELLPSCVPSKL
YRTKTPEKWASLVTTTYAK-APYTQKRARPL-------------------------TVQ-
EQVVDT---AC-----------------------------------------LKWPLLFS
RLFEVTTLS-GPQL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQK-E--KVLLELSFIEVMS---------LITNREAR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLMLSTLHEEEYEFRSPSSVAVAEL
VAMFLEGLKERSVFAMALQDRKATGTQPEDSTLL-PFKKGDLLILTKKQGLLASE-NWTL
AQNDRTEKTGLVPTSCLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEAPPEEQ-P
EENLHTLEEFSYEF-FRVPEKETVSRAVLPLARTRGQLWAHSAEPLRQPLLRRV----HA
NAEL-------RDAACQ-I-F--ID----ILSYMGDYPSRQAWT

PF00784 // ENSGT00900000140810_6_Domain_12 (2325, 2430)

SLELTDQIFSSALQEA
VLQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-V
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRICHKVYLPNDTSE--MLEVGANTR
VRDACDSIAARLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTIPYQVYFMRKLWLNVAPGKDVKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLASLIYKARFGDDRPQLASIPKILRELVPENLTRLMSPEEWKKN-ILLACNKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAS
WSSGSTYFHMVLGGLGRGSRLLCETSLGYKMDDLLTS-----YVQQLISAVNRQRAPRGS
VPSHP----------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAAMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAVANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFMATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSVEDKQLLSLGT
PSEYHYLTMGNCTSCERLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASEVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYRHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNQAFLQPKNMYD--ARFGIAHFAGEVYYQVEGFL
EKNRDV---LSTDILTVVYSSKNKFLREIFNLESAETRLGRGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELG
LRQLRYSGMMETVHIRKSGFPIRYAFEEFSQRFGVLLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLVRQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPCFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIQRPLRYPLLYHEDDADCLAALTVWNV
ILRFMGDLPEPVLYARSSQQGS-SMMRQIHDTLSRGHGAQAPQHSRF-------------
---------------------AQVA----SQL-NIGGEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPLQVI
LATGESLTV---SVDSASTSQEM--CVHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESQAVQELLPSCIPHRL
YRTKPPDRWASLVTAACAK-APYTQRQATPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVAKRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFASPSSVAVAEL
VALFLEGLKERSVFAMALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
SQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSFE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NIDL-------WDIACQIFVAIL--------RYMGDYPSRQAWPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFMLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYFPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLSYQVYFMRKLWLNITPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALAST----------------------------------

----------------------------GDHVWLDSPSTNKTDVAIGGIVKET-KPGKIL
VEDDEGKEHWIQAEDLGTLSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGMVHNLLIRYRQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHVGELPPHVFAIANNCYFNMKKNKRDQCCVIX
XXXXXXXXXXXXXXXXXXXXXXXXXXWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMSAEEKKLLSLGT
PSEYHYLTMGNCTSCEGLNDAKEYAHVRSAMKILLFSDSENWDLSKLLAAILHLGNVEFM
AAVFENLDSSDVMETPALPVVMKLLEVQHQVLRDCLIKHTILIRGEYVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAGDSKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENLAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQVYGTDITMLQKLNNVH----ASNKAFLQPKNIHD--TRFGIAHFAGKVYYQAEGFL
EKNXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX-----
----XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLFDRELC
-RQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFRVVLPSAERM-QLRDKFRQMTQRIAEV
WLGTDKDWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDHQDTLLEIQRSQAL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

EAAAVNIQRVLRGYKY-RKEF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--GAVTLQAHWRGYCTRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILMGFERLQAIARSHLLLRQYQAM

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RQRMVQLQALCRG
YLVRQQV

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

KRAVVVIQAHARGMAARRRV

ENSGT00900000140810_6_Linker_6_7 (931, 1259)

QQQK--------------------------
-----------------------------------GNGPLIVPAEEPKSQSALPAKKR-M
SIYDTVT--DTEMVEEVFGFLPSMIGGQEGQAPARFEXXXXXXX-XXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXXXX---XXXXXXXX---X-XXXXXXXXXXXXXXXX-XX
XX-XXXXXXXXXXXXXXX-XXX-XXXXXXXXXXXXXXXXXXXXXXXX-------------
-XX------XXX-X------XXXXX----XXXXXXXXXXXXXXXXXXX-------XXX

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

XX
XXXXXXXXXXXXXXXX--XXXDEICQ-ICKQLSE-NYRRSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFINQGPAGYGPFCAERLRRTYANGVRTEPPTWLELQAVKSKKHIPIQII
LVTGESLTL---SVDSASTSREI--CLHIAQKRGLSDHLGFSL-----QVAVYDKXXXX-
XXXXXXXXXAVAQCEQLAKERGESQR-----QAPWRLYFRKE--F-FTPWHDSGEDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLAQHCYVQLGAS--VGSKAIQELLPSCVPTKL
YRTKPPEKWTSLVTAAHIK-APYTQTRATPL-------------------------AVQ-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTALS-GTRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KMLLELSFPEVMG---------LVTNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------ARGGQRLLLSTLH-EEYEFVSPSSVAIAEL
VALFLEGLKERSV

PF07653 // ENSGT00900000140810_6_Domain_10 (2114, 2180)

FAMALQDRKATD----DATLL-PFKKGDLLILTKNQGFPTSE-NWTQ
CQNDRTGKTGLVPTACLYIIPTTAKPPEQLLRLLAMSPEKRKLAAQEGQPAEPP--EKPS
KEEPYTLEEFSYE-FFRAPEKDTVSRARLPLARARGHLWAYGSEPLRQPLLKRVHAIXXX
XXXX-------XXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXX-XXXXX-XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXTGPRKQPPHQVEVEAAEQNVSRICHKVYFPNDTSEXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXX---VFSQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLSVVPGKDVSADTILHYHQELPKYLRGFHKCSREDAV
HLASLIYKAQFDNDRSQLANVPKILRELVPENLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIVLIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSTVSKQRGSKTQ
ATAN-----------------------------------

----------------------------GDHVWLEAPYVNKTNVAIGGIVKNT-KPSKIL
VEDDEGKEHWIHADNLGALSHMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 733)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQALPLYTLEQVHLYYKRHVGELPPHVFAIADNCYFNMKKNKKDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQATEERNYHIFYSMLMGMSAEEKRLLGLGT
PSEYYYLTMGNCTSCEGLNDAKDYAHLRSAMKILMFSDSENWDLSKLLAAILHLGNVKFM
AAVFENLDSSDVMETPSFAIVLKLLEXXXXXXXXXXXXHSIAIRGEFVTRPLSVSQAADR
RDAFVKGIYGHLFLWIVKKINAAIFVPPPDNPKHVRRAIGLLDIFGFEIFK-NSFEQLCI
NLANEHLQQFFVQHVFTMEQEEYRSENITWDYIQYTDNRPTLDLLALKPMSIISLLDEES
RFPQVCGTDATMLQKLNSVH----ANNKAFLQPKNVHD--GRFGIAHFAGKVHYHVEGFL
EKNRDV---LSSDILTLVHSSKNKFLQEIFKLEATEIKLGRGTIFKTKAGSQ--------
----LFKSSESSKQPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-
--XXXXXXXXXXXXXXXXXXXXXIHMGFESLQAIARRHLLANQYQMM

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RHRVVQLQALCRG
YLVRQQM

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QVK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVLLQAHARGMAARRKL

ENSGT00900000140810_6_Linker_6_7 (931, 1281)

QHLKVNXXXXXXXXXXXXXXXXXXX-XX--
--X-----------------------XXX------XXXX-XX-XXXXXXXXXXXXXX--X
XXXXXX---X---XX--XX--XXXXXXXXXXXXXXXXXXXXXX--------X-XXXXXXX
XXXX---XXXXX--XX----XXXX-XXXXXXXXX----XXX-XXXXXXXXX-XX-XX-X-
---XXXXXXXXX---XXXX-XXXXXXX---XXXX----------X----XXXX-XXXXXX
XXXXXXXXXXXXXXXXX---XXXVT----SKL-NVGDDTFEPDGPISD-------RXXXX
XXXXXXXXXXXXXXXX--XX

PF00784 // ENSGT00900000140810_6_Domain_7 (1281, 1327)

DEVYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX
XXXXXXX---X-XXXXXXX---X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFWSL-
GSGRDHVMDAIAQCEQLTRERGENER-----QSPWRLYFRKE--F-FTPWHNSQEDPVST
KLIYCQVLHGVWS-GEYSFEKEEDLIELLARHCYVQLGAS--VESQAVQELLPTCIPSKL
YRTKLPEKWASLVTEAHAK-APYTQQQAKPQ-------------------------AVR-
EQVVDA---AL-----------------------------------------LQWPMLFS
RLFEVSTVS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDKK-E--KLLLELSFVEVMSLV---------THR------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------EARGGQRLMLSTLHEEEYEFLSPSSVAIAEL
VALFLEGLKERSVFTMAMQDRKA---T-DDSAIL-TFRNGDLLIWTLAKRQNKRQRGA--
-----IGNEHXVPMASLYTIPTVTKPSPWLLNLLAMSPEKRKLVVQEGRPAEPLPEEQ-P
QEKSHTLEEFSYE-FFRAPEKETVSRAMLPLARTRGHLWAHSAEPLRQPLLKCV----HA
----------------NAFSLAATP----ILRYMGDYPARXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-XXXX

PF00784 // ENSGT00900000140810_6_Domain_12 (2360, 2431)

XXYSEERGWQLLWLCTGLFPPGKALLPHVQKFIDTRRK-KP
LAPDCSRRIQRVLRIGPRKQPPHQVEVEAIGKNVFRINHKVFFPNDTSE--MLEVSSSTR
VRDVCESISAKLQLASWEGCSLFIKIADK---VIIQNEGDFFIDSLREVSDWVKNNKPQK
E----GGP-MTLPYQVYFMRKLWLNVTPGKDVNADITLHYHQELPKYLRGFHKCTREDVV
HLAGLIYKAQYGNDRAQLASLPKILRELVPENLTRLMSSEEWRKS-ILLACEKHKDKTSE
EAKVDLLKWICRWPTFGSAFFEVKQSSEPSYPDIIIIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTL-PF--KAS
WSSGSTYFHMALGSLGHGSRLLCETSLGYKMDDLLTS-----YVQQLLNTLNKQRGSRAV
ALAE-----------------------------------

----------------------MVIYRKGDHVWLEAQPHSEFNVPIGAVVKDS-DSGRIL
LEDDEGKEHWITARNMHMVRPMDPSTAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLHEAGMVHNLLIRHQQHKIYTY
TGSILVAVNPYQLLPLYTVDLIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTESTKLILQFLAAVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNHSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNLEQKKMLNLGT
ASEYSYLTMGNCTSCDSRNDAKEYAHIRSAMKILMFSDSEHWDISKLLAAILHLGNVEFE
AAVYDNLDCSDVMDSPHFSIATKLLEVDYSELQNSLTNLSIIVRGESVSRPLNVAQAADG
RDAFVKGIYGRIFLWIVNKINSAIFNPTSQKPKNTRQSIGLLDIFGFENFSNNSFEQLCI
NIANEHLQQFFVHHVFKLEQEEYLAEHITWNNIDFTDNRQTLEVIALKPMNIISLIDEES
KFPK--GTDATMLIKINSLH----GKSRVYIPPKSDHD--TKFGINHFAGAVFYESKDFL
EKNRDT---LSANVMQAVHSSKNKFLKEIFQVETTPTSLGRGTIRHLGSDQAYK------
-------GLDTTKRLSTLGGQFKQSLEKLMKILGQCQPYFIRCIKPNDYKKPLLFDRELC
IKQLRYSGMMETIRIRKAGYPVRYTFEEFFERYRVLLPRSALE-PLKNDARQCCIRISEA
VLGKDESWQAGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDYHDTILELERQKILT

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

DKVLLIQKVMRGFKD-RKQ

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RK-
--SAIAIQAAWRGYCCRKDF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

RMIMLGFGRLQALYRSRQLAKQYETARA

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 906)

HIIRFQAACRG
YLIRQKN-----------------------------KVKL--EARNIRLEEEKRLISV--
--LGP-------------VKAR----EEAMKLEKEHLAI-LEEEEEEGQRMNNDFVDR-H
TNYDVIS--DQEMVDKIFGFLPSMIGGQEGQAPLGFEDLETKP--SKLEEVDLDMIPMSV
ELEE---EADGLEDYTFPKFAATYFQGSSTHTHIRKPLRHPLLYHDDKDNVLASLVVWVI
ILRFMGDLPEPTMFAKNA--KSGSMMTQIYDTLGRKNQVQFKN-S----PDTR-ESKKDN
KISKGISSLKLKRSSKL---TGKVT----DQL-KSGEEGFQEDSSISE-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIIGNAILRPA--IRDEIYCQ-ICKQLTE-NSSRSSYARGWILLSLCLGCF--PP
SDTF-VKYLLNFIHNGPSGYAPYCAERLRRTYVNGARTEPPSWLELQATKQKKPIMFNVT
LMNGQSI--TV-PADSASIAKEI--CQFIADKTKLKDIFGFSL-----YIAVFDKVWSL-
GGGRDHVLDAISQCEQLVKERGTHER-----HAPWRLYFRKE--I-FTPWHNSQEDPIST
DLIYHQVIRGIRF-GEYRCEKEEDLVEIGAKYCYIQFGDT--IHNELVQKVLHDCIPVKQ
LKSKPLEKWVSLITYAHAK-APYTQDRLSRQ-------------------------AVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNH----------------------------------------
-------------------------------------------------------FILAV
NWKGICFLDES-E--KRLLELTFPEITGIH---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RAVKSFGQSCTLITLRAEEFVLTSVNSIVIAEL
VVMFLEGLKKRSRFAVAMHEKK---FQ-EDPAVL-SFKKGDLLILTEDKRLDANS-GWIH
AQNDRTGKTGNVFLEEMYIIPSLTKPSGQVLSLLMMSPDQRRTASQNSYIEEPD-EED-L
KVKPYTLEEFSYE-HFRTPEKESISKAVLQKSRGHSQLWAHSKDPLKQPLLKAA----CT
DPDV-------RDVACQAFI----D----ILLLFSLGPENSRGKE-ELRP--W--NTSTE
IIPR--------------------PHYWGHTYIKQR---------RRSGGFISSA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

---------------------------------LNPTPADKTRVAIGGIIKET-KPGKIL
VEDDEGKEHWIQAEDLGTLSSMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTAEQVQLYYKRHVGELPPHVFAIANSCYFNMKKSKRDQCCIIS
GESGAGKTETTKLILQFLATISGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFTSSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLLGMSAEEKKLLGLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHVRSAMKILMFSDSENWDLSKLLATILHLGNVEFM
AAVFENLDSCDVMETPAFPTVMKLLEVKDQALRDCLTKHSIIIRGEFVTRPLNITQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVQRTIGLLDIFGFENFQKNSFEQLCI
NLANEHLQQLFVRHVFTVEQEEYRAESIAWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDATLLQKLKSVH----ANNKDFLQPKNIHD--AQFGIAHFAGQVHYHVEGFL
EKNRDV---LNRDVLALVHSSQNKFLREIFGLESKESRRGPGTIVRVKAGS--QQ-----
----FKS-SDSSKQPSTLAGQFKQSLDQLMKILTNCQPYFVRCIKPNDYKKPLLFDRELC
IQQLRYSGMMETVHIRKSGFPIRYAFEEFSQRFRVLLPSAVRT-ELRNKFRQMTLCIAER
WLGTDKEWKMGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KENQDTLLEVQRSQALD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

EAAIRIQRVMRGYKR-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGHYSQRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

KLILLGFERLQAMARSHLLAKQYQALR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 907)

QRMVKLQALCRG
YLVRQQVQAKRRAVVVIQAHARGMALGW-WQLRPHGVP----------------------
--------------------------------------LV-IPAEEQKSPSAVPKRKR-K
SIYDTIT--DTEMVEQVFGFLPSLTGGQDGPATPHIEDLEEM--TQKLPEVDLDTVPMME
E---PEDD---LAQYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCSAALAVWSI
ILRFMGDLPEPVLFTRSILHGG-SVMGQIHDALGKDSSSQPPQHSRSA------------
----------------------QVA----SQL-NIGEEAFEEDSPLSD-------RPMSN
LE

PF00784 // ENSGT00900000140810_6_Domain_7 (1263, 1368)

KVQFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NYKTSSLARGWILLGLCLGCF--PP
SQRF-LKYLLNFIGQGPVGYGPFCAERLRRTCANGVRTEPPSWLELQAVKSKKHIPIHIS
LATGESLTV---MVDSASTSREV--CLHIANKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDALAQCEQLARERGESER-----QAPWRLYFRKE--F-FTPWHDSQEDPVST
HLIYRQILHGVWL-GEYPFEKEEELVELLAQHCYVQLGAS--AGSQAIRELLPSCVPSKL
YRTKTPEKWASLVTTTYAT-APYTQKQARPL-------------------------TVQ-
EQVVDT---AC-----------------------------------------LKWPLLFS
QLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLYFLDQK-E--KVLLELSFLEVMS---------LITNREAR---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------GG--QRLTLSTLHEEEYEFRSPSSVAIAEL
VAVFLEGLKERSVFAMALQDRKATEDS----TLL-PFKKGDLLILTKKQGLLASE-NWTL
AQNDRTEKTGLVPTSCLYAIPTVTKPSAQLLSLLAMSPEKRKLAAQEGRPTEAPPEEQ-P
EENLHTLEEFSYEF-FRIPEKETVSRAVLPLARTRGHLWARAPRPARLRARPLR----VG
GDQLRARLRIGGDGRCSLT-A--AP----ILRYMGDYPSRQAWTSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFSSALQEA
VLQDEVYCQILKQL-THNTKRYSEERGWQLLWLCTGLFPPGKALLPHAQKFIDTRRRK-V
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNVSRVCHKVHLPNDTSE--MLEVGANTR
VRDACDSIAARLQLASWEGCSLFIKIADK---VISQKEGDYFFDSLRHVSDWVKKNKPQK
E----GAP-VTIPYQVYFMRKLWLNVAPGKDVKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKARFGDDRPQPASIPKILRELVPENLTRLMSLEEWKKN-ILLACNKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSHPDIILIAINRHGVLLIHPKTK--------
-----------------------------------------------DLLTTYPFTKIAS
WSSGSTYFHMVLGGLGRGSRLLCETSLGYKMDDLLTS-----YVQQLISTVNRQRGPRGS
VSSPL----------------------------------

----------------------MVVFRKGDHVWLDTQPKSEFNVPIGAVVKES-DSGRIL
LEDDEGKEHWITARNMHMVRLMHPSSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLHEAGMVHNLLIRHQEHKIYTY
TGSILVAVNPYQLLPLYTVDQIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTESTKLILQFLAAVSGQHSWIEQQILE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIHFNKNGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNTEQKKMLNLGT
ASEYTYLTMGNCMSCDSRNDAKDYAHIRSAMKILMFSDSEHWDISKLLAAILHLGNVEFQ
AAVYDNLDCSDVIDSPHFSIATKLLEVDYSELQNSLTNLSIIVRGESVSRPLNVVQAANG
RDAFVKGIYGRIFLWIVNKINSAIFNPTSQKPKDRHQSIGLLDIFGFENFSNNSFEQLCI
NIANEHLQQFFVHHVFKLEQEEYLAEHITWNNIDFTDNHQALEVIAVKPMNIISLIDEES
RFPK--GTDATMLVKINSLH----GKSKIYIPPKSVHD--TKFGINHFAGVVFYESKDFL
EKNRDT---LSANVMQVVHSSKNKFLREIFQVETTPPSLGRGTIRHLGSDHVYKCGFLLS
RTPGHGQGMDTTKRLSTLGGQFKQSLEKLMKILEQCQPYFIRCIKPNDYKKPLLFDRELC
IKQLRYSGMLETIQIRKAGYPIRYSFEEFFERYRFLLPWSLRQ-KLKNDTRQSCISISEA
VLGKDESWQVGKTKIFLKDYHDTVLELQRQNVLTDKVLLIQKVMRGLKD-RKQFLKQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RK-
--SAVAIQSAWRGYFCRKEF-

ENSGT00900000140810_6_Linker_4_5 (862, 889)

RMVLLGFGRLQALYRSRQLAQQYEATR

PF00612 // ENSGT00900000140810_6_Domain_5 (889, 906)

ARIVRFQAVCRG
YLLRQ

ENSGT00900000140810_6_Linker_5_6 (906, 911)

KVAEQ

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 932)

RKAACVIQAYARGMFARQTY-

ENSGT00900000140810_6_Linker_6_7 (932, 1259)

RRIKGENKM--EARNIHLKEEKHLVPV--
--LGP-------------LKGG----EEAERLEKEYLPT-QETEEAEAGQRRNVLDDK-P
TNYDVIS--DQEMVDKIFGFLPSVIGGQEGQAPVGFEDLETKP--NKLEEVDLDMVPMSV
ELEE---EAHGLEEYTFPKFAATYFQGSSTHTHIRRQLRHPLLYHDDKDNVLASLAVWVI
ILRFMGDLPEPPMFAKTATTKSSSVMTQIYDTLGKKSQVQLRNDS----PNMR-EGRRDY
KISKGISSLKLKRSSKL---TAKVT----DQL-QSGEEAFQEDVSISQ-------RPM

PF00784 // ENSGT00900000140810_6_Domain_7 (1259, 1370)

SN
LEKVHFIIGNAILRPA--IRDEIYCQ-ICKQLTE-NSNRSSYARGWILLSLCLGCF--PP
SDTF-VKYLLNFIHHGPTGYAPYCAERLRRTYTNGARTEPPSWLELQATKQKKPIMFNVT
LMNGQSI--TI-PADSASTAKEI--CQFIADKIKLKDVFGFSL-----YIAVFDKVWSL-
GGGRDHVLDAISQCEQLVKERGTHER-----HAPWRLYFRKE--I-FTPWHDTHEDPVGT
DLIYHQVIRGIRF-GEYRCEKEEDLVEIGAKYCYIQFGDT--IHNEFVQKVLHDCIPVKQ
LKSKPLEKWVSLITYAHAK-APYTQDHLSSQ-------------------------TVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNR----------------------------------------
-------------------------------------------------------FIVAI
NWKGICFLDES-E--KRLLELSFPEITGIH---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RAVKSFGQSCTLITLRAEEFVLTSVNSVVIAEL
VVMFLEGLKKRSRFAVAMHEKK---SQ-EDPSIL-SFRKGDLLIFTEDKTLDADS-GWIS
AQSERTGKTGNVFLEDIYIVPSLTKPSSQVVSLLMMSPDQRRTASQNSFMEEPD-EED-I
KVKPYTLEEFSYE-HFRAPEKESISKAVLQKSRGHSQLWAHSKEPLKQPLLKRA----CT
DPDL-------RDLACQAFI----A----IMKFMGDYPSKQAH

PF00784 // ENSGT00900000140810_6_Domain_12 (2324, 2430)

SSIEVTDQIFVPAIQEE
VLRDEIYCQIMKQL-TENRNRYSETKGWQLLWLCTGLFPPSKSLLKHAQKFIETRQK-ET
LAPSCRRRIQTVMRSGCRKWPPHPVEVEAILQNNTKISHKICFPNDTEQ--AFDVGTNTK
IQTLCQNIASKLQLQSWEGFSLFVKIADK---VISQNEADYFFDSLRQVTDWNRRNKPGK
D----GAA-LSVAYEVYFMRKLWLNVTPGRDLKADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

FHYHQELPKYLRGYHKCSKDEAV
QLAGLIYKARFNNDRTQLAAIPKILKELLPDNLLRAVSPDEWKKS-IIAAYSKYEGKTVD
EAKIAFLKMIHRWPTFGSAFFEVKQASEPNFPEIVLIAINKQGVSLIHQKTK--------
-----------------------------------------------DILVVYPFNKISN
WSSGSTYFHMTIGNLVRGNRLLCETSLGYKMDDLLTS-----YVRLLMNAVNKQKNLPA-
---------------------------------------

----------------------MVVFRKGDHVWLEAHPNSEFNVPIGAVVKDS-DSGRIL
LEDDEGKEHWITARNMHMVRPMDPSTAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VEDMIRLGDLHEAGMVHNLLIRHQQHKIYTY
TGSILVAVNPYQLLPLYTVDLIRLYCNKRIGELPPHVFAIADNCYFNMKRNKRDQCCVIS
GESGAGKTAGSTRLIRD-----IEHIWITRKSVIKVLSVLFPSAFGNAKTIRNDNSSRFG
KYIDIYFNHSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMNAEQKKMLNLGT
ASEYTYLTMGNCTSCDSRNDTKEYAHIRSAMKILMFSDSEHWDISKLLATILHLGNVEFE
AAVYDNLDCSDVMDSPHFSIATKLLEVDYSELQNSLTNLSIIVRGESVSRPLNVAQAADG
RDAFVKGIYGRIFLWIVNKINSAIFNPTSQKPKNTRQSIGLLDIFGFENFSNNSFEQLCI
NIANEHLQQFFVHHVFKLEQEEYLAEHITWNNIDFTDNRQALEVIALKPMNIISLIDEES
KFPK--GTDATMLIKINSLH----GKSRVYIPPKSDHD--TKFGINHFAGAVFYESKDFL
EKNRDT---LSANVMQVVHSSKNKFLKEIFQQTACAY-----------------------
----SSQGLDTTKRLSTLGGQFKQSLEKLMKILGQCQPYFIRCIKPNDYKKPLLFDRELC
IKQLRYSGMMETIRIRKAGYPVRYTFEEFFERYRVLLPRSALE-PVKNDARQCCIRISEA
VLGKDESWQAGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDYHDTILELERQKIL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

TDKVLLIQKVMRGFKD-RSVMLQKN--
---AGLLHMQWRSSCCGYSHTYKIMLGFGRLQALYRSRQLAKQYEAA

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RAHIIRFQAACRG
YLIRQKVAAQMKAVSVTYRHRQGACLLARLHKQGHLENKVKLEARNIRLEEEERLISILG
PVKA---------------------REEAMKLEKEHLATLEEKEEEEGQRMNNDFVDR-H
TNYDVIS--DQEMVDKIFGFLPSMIGGQEGQAPLGFEDLETKP--SKLEEVDLDMIPMSV
ELEE---EADGLEDYTFPKFAATYFQGSSTHTHIRKPLRHPLLYHDDKDNVLASLVVWVI
ILRFMGDLPEPTMFAKNAT-KSGSMMTQIYDTLGRKNQVQFKNDS----PDMR-ESKKDN
KISKGISSLKLKRSSKL---TGKVT----DQL-KSGEEGFQEDSSISE-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVHFIIGNAILRPA--IRDEIYCQ-ICKQLTE-NSSRSSYARGWILLSLCLGCF--PP
SDTF-VKYLLNFIHNGPSGYAPYCAERLRRTYVNGARTEPPSWLELQVTFLFARVMLPCP
FLYMSALVLLIFPSST-PRHKNTHNYQSVT-STSIYS--AFQ-----ILIFLCWEVWSL-
GGGRDHVLDAISQCEQLVKERGTHER-----HAPWRLYFRKE--I-FTPWHNSQEDPIST
DLIYHQVIRGIRF-GEYRCEKEEDLVEIGAKYCYIQFGDT--IHNELVQKVLHDCIPVKQ
LKSKPLEKWVSLITYAHAK-APYTQDRLSRQ-------------------------AVK-
EQLVDF---AR-----------------------------------------FQWPLLFS
RFFEVTKFS-GPSL----------------------------------------------
----------------PKNH----------------------------------------
-------------------------------------------------------FILAV
NWKGICFLDES-E--KRLLELTFPEITGIH---------TN-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RAVKSFGQSCTLITLRAEEFVLTSVNSIVIAEL
VVMFLEGLKKRS

PF00018 // ENSGT00900000140810_6_Domain_10 (2113, 2177)

RFAVAMHEKKS---Q-EDPAIL-SFKKGDLLILTEDKRLDANS-GWIY
AQNDRTGKTGNVFLEE

ENSGT00900000140810_6_Linker_10_12 (2177, 2323)

MYIIPSLTKPSSQVLSLLMMSPDQRRTASQNSYIEEPD-EED-L
KVKPYTLEEFSYE-HFRTPEKESISKAVLQKSRGHSQLWAHSKDPLKQPLLKAA----CT
DPDV-------RDVACQAFIA-RSP----IMKFMGDYPSKQT

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

HSSVEVTDQIFVAAIKEE
VLRDEIYCQIMKQL-TENRNRYSVTKGWQLLWLCTGLFPPSKSLLKHAQKFIETRQK-EP
LALECKRRIQTVMRSGSRKWAPHPVEVEAILQNNTKISHKICFPNETEQ--TFDVGTNTK
NRTLCQNIASKLQLSSWEGFSLFVKIADK---VISQNEADYFFDSLRQLTDWTKRNKPVK
D----VTV-PWSSETAFFV--GWFILTPGKDLKADSIFHYHQELPKYLRGYHNCSRDEAV
QLAGLIYKVRFNNDRTQLATIPKILKELVPDNLLRVTSPDEWKKS-ITAAYSKHEGKTVD
EAKIAFLKIIYRWPTFGSAFFEVKQTSEPNFPEIVLIAINKQGVSVIHQKTK--------
-----------------------------------------------EILTVYPFNKISN
WSSGSTFFHMTIGNLVRGSRILCETSLGYKMDDLLTS-----YVHLLMNAVNKQKS----
---------------------------------------

----------------------MAVFKLGDYVWLYPPSASETTVAIGGIIRKR-EPGKVL
VEDDEGKEHWICV-DFGSLSSMHPNSAHG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIHLGDLNEAALVHNLLIRYQQH-IYTY
TGSILVAVNPFQLLPLYTLEQVRLYYSHHVGELPPHIFAIANICYFNMKKNKRDQCCIIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEVFGNAKTIHNDNSSRFG
KYIDIYFNHSGVIEGARIEQFLLEKSRVCRQAQEERNYHIFYCMLVGMSAEEKNLLCLGT
PSEYRYLTMGNCSSCEGLDDTMNYAHVCSAMKILMFSDSEKWDISKLLAAILHLGNVEFM
AVVSENLDSSDVMEPSTFPIVIKLLEVQRQALQDCLTKHSIIIRGEFVTRPLNITEAADR
RDAFVKGIYGNLFLWVVKKINAAIFTPPSQDPRRVRRAIGLLDIFGFENFQSNSFEQLCI
NLANEHLQQFFVQRVFAMEQEEYRVEDIAWDYIHYSDNRHVLDLLVLKPMSIISLLDEES
HFP---GTDITLLQKLKSVH----AHNKAFLQPKTIHD--ARFGIAHFAGEVYYKTDXXX
XXXXXX---XXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXX-----
----XXXSTESTKQPSTLAGQFKQSLDQLMKILTTCQPYFIRCIKPNEYKKPLXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XLRNNFRQMTLCIADM
WLGTDKDWKMGKSKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 814)

KDHQDTLLEIQRSQVL

PF00612 // ENSGT00900000140810_6_Domain_3 (814, 835)

ATAALSIQRVLRGYKH-RKEF

ENSGT00900000140810_6_Linker_3_4 (835, 838)

LRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

KQ-
--AAVTLQVNWRGFSTRKNF-

ENSGT00900000140810_6_Linker_4_5 (862, 888)

KLILLGFERLQAIARSHLLAREYQAL

PF00612 // ENSGT00900000140810_6_Domain_5 (888, 908)

RERIVHLQARCRG
YLIRRAA

ENSGT00900000140810_6_Linker_5_6 (908, 911)

QDK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVIIQTHARGMAVRKSL

ENSGT00900000140810_6_Linker_6_7 (931, 1258)

WRQK--------------------------
-----------------------------------ADEPLVVPAAQQRGPSDLPAKKW-K
SIYDTVT--DTEMVEEVFGFLPSMIGGQENQVSLGFEDLESRTE--QLPEVDLDTISMVE
E---PEEEVDSL-AYTFPKFAATYFQKSASHTHIQRLLRHPLLYQEDDKDCSXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--------XX-XXXXX-XX-------------------
------XXXXXXXXXXXXXXXXXVA----SQL-SIEKEMFELSNSISD-------RP

PF00784 // ENSGT00900000140810_6_Domain_7 (1258, 1370)

MSN
LEKVHFIVARAILQPN--LRDEIYCQ-ICKQLSE-NFNMSSLARGWILLSLCLGCF--PP
SERF-MKYLMNFIGQGPAGYGAFCAKRLRRTFANGVRMEPPTWLELQXXXXXXXXXXXXX
XXXXXXXXX---XXXXXXXXXXX--XXXXXXXXXXXXXXXXXX-----XXXXXXXXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXX-----XSPWRIYFRKE--F-FTPWHDSRADPVST
ELIYRQVIRGVWS-SEYSFEREEELVELLAQHCYVQLGAS--AGSKAIQELLPSCIPTKL
YRTKPPEKWASLVATVYTKXXXXXXXXXXXX-------------------------XXX-
XXXXXX---XX-----------------------------------------XXXXXXXX
---XXXXXX-XXXX----------------------------------------------
----------------XXXX--------XX-XXXXX------XX-XX---------XX--
---------XX----------------------XXXXXXX----XXXXXXXXXXXXXXXX
XXXXXXFLLRS-Q--KLLT-LG---------------VIPGGEGQGLTTNPPQ----EPP
RLSS-----TGNASESTRSVTTGWFPVWCYAQTTVQMSK----------KHTEAQLTQGP
SRSTGQSQYPVSAVAVYTALLCVAQYPPTSLPPQIPHILASPLLA-P------------K
RPPVVLALALLLLLRQGPLVMMP--CVFRTPQGEQRLTLSTLHEEEYEFATSSSVAIADL
VAMFLEGLKERSVFTMALQDRKATXXX----XXX-XXXXXDLLILT-KMGLLASE-NWTM
GQCDRTGRMGLVPMSCLYIVPTVVKPSAQLLRLLAMSPEKRKLAAQEERPTEPSPEEQ-S
KENSHTLEEFSYE-FFRAPEKETVSKAVFPLARARAHLWAYSSEPLRQPLLKHV----HA
NASL-------RDCACQTF---TVP----ILKYMGDYPSKQA

PF00784 // ENSGT00900000140810_6_Domain_12 (2323, 2431)

WSSLELTDQIFSLALQEV
ALQDEVYCQILKQL-TYNSNRRSEERGWQLLWLCTGLFPPSKVLLPHTQKFVDTRRKK-L
LALDCSHRLQKVLRAGPRKQPPHQVEVEAAEQNVTRICHKVYFPNDTSE--MLEVGTNTR
VRDVCQSIATKLQLASWEGCSLFVKITNK---VFSQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-TMIPYQVFFMRKLWLNVTPGKDVNADIIFHYHQELPKYLRGFHKCSREDVL
HLAGLIYKAQFDNDRSQLASVPKILRQLVPENFTRLMSSEEWKKS-IPLAHDKHMDKTVE
EAKVAFLKWICRWPTFGSAFFEVK------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------

----------------------MSGFRLGDHVWLGPPSTHKTGVAVGGIIKET-KPGKVL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELAPHVFAVANNCYFNMKRNKRDQCCIIS
GESGAGKTETTKLILQFMATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGEFVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNQAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRRAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMLETVRIRKSGFPIRYAFEEFSQRFGVLLPSAVRM-QLQGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDRQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RRE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 890)

KLILVGFERLQAIARSQQLARQYQAMRQ

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RMVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPCFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALTVWNV
ILRFMGDLPEPVLYARSSQQGS-SMMRQIHDTLGRGHGAQAPQH-RF-------------
---------------------AQVA----SQL-NIGEEALESDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREM--CVHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESQAVQELLPSCIPHRL
YRTKPLDRWASLVTAACAK-APYTQRQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVITLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFASPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSFE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDF-------WDIACQIFVAIL--------RYMGDYPSRQAWPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYFPNDTSE--MLEVAANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLSYQVYFMRKLWLNITPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLASVPKILRELVPKDLTRLMSLEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGSLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALANT----------------------------------

----------------------MSGLRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDFGALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHIGELPPHVFAIANNCYFNMKKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPVLEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSAEDKQLLSLGM
PSEYHYLTMGNCTSCEGLDDAKDYAHIRSAMKILQFSDSENWDLSKLLAAILHLGNVGFI
ASVFENLDSSDLMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRPLNIAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFKNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYYSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEES
RFPK--GTDLTMLQKLNSVH----TNNKAFLQPKNIHD--ARFGVAHFAGEVYYQAEGFL
EKNRDV---LSTDILTLVYSSKNKFLREIFNLELAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSTKRPSTLAGQFKQSLDQLMKILTKCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFQEFSQRFGVLLPSAVRM-QLRDKFRQMTLGITDM
WLQTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQLLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALRIQRVLRGYRH-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTLQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAMVRSQLLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RKAVVVIQAHARGMAARRNF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQRK--------------------------
-----------------------------------ASVPLVIPAEAQKSQGALPAKKR-K
SIYDTVN--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTE--KLPEVDLDAIPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDFPEPVLYSRSSQQGG-SVMQQIHDTLGRGRGAQALQHGGSAQ-----RPGRKD
RGTKDISSMKLKRSSRV---TGQVA----SQL-SIGEEALEPDGLGAD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPS--LRDEIYCQ-ICKQLSE-NFKTSSLARGWILLSLCLGCF--PP
SERL-MKYLLNFIGQGPVTYGPFCAERLRRTYANGVRVEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---PVDSASTSREV--CTHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERGESHR-----QSPWRIYFRKE--F-FTPWHNSQEDPIST
ELIYRQVIHGVWS-GEYSFEKEEELVELLAQHCYVQLGAS--AESKAVQELLPSCVPHKL
YRTKPPDRWASLVTAACAK-APYTQKQVTPL-------------------------AVR-
EQVVDA---AL-----------------------------------------LQWPLLFS
QLFEVITLS-GSRL----------------------------------------------
----------------PKTK----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LATNRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGGQRLLLSTMH-EEFEFVSPSSVAIAEL
VALFLEGLKERSMFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLALE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQPAELQTKEP-P
KEKPHTLEEFSYE-FFRAPEKETVSRAVLPLSRARGHLWAYSSEPLRQPLLKQV----HT
NIDL-------WDVACQIFVAIL--------RYMGDYPSRQAWPTV

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHE
ALRDEVYCQILKQL-THNSNRHSEERGWQLLWLCTGLFPPGKGLLPHAQKFIDTRRGK-L
LAPDCSRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKIFFPNDTSE--MLEVGANTR
VRDVCDSIATRLQLASWEGCSLFIKITDK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVAPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDVI
HLAGLIYKAQFDNDRSQLASVPKILRELVPENLTRLMSSEEWKKS-IPLAYDKHKDQTVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRRGVLLIHPKTKVAAGPPEG
LGATWSRDPCKWGCGHLCGVSCLSPVPEHAQPTGSGGALPTHPFCPQELLTTYPFTKISS
WSSGSTYFHMALGSLGRGSRLLCETSLVSPGPFSQPR-----------CTGQSCWGLASP
PHPFQVAH-------------------------------

MPPV-------CSVAQPSPSFTANIVLSGDHVWLDLPSINKTSVAIGGIVKET-QPGKVL
VEDDEGKEHWIRAEDLGALSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMILLGDLHEAGVVHNLLIRYQQHQIYTY
TGSILVAVNPFQTLPLYTPEHVQLYYGRHVGELPPHVFAIANSCYFSMKKNKRDQCCVIS
GESGAGKTETTKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIRNDNSSRFG
KYIDIYFNPSGVIEGARIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSPEEKKLLGLAT
PSEYHYLTTGNCTPHEGLNDAKDYAHVRSAMKILLFSDSENWDISKLLAAILHLGNVEFM
AAVFENLDSSDVMESPAFPCAMKLLEVQHQALRDCLVKHTIPIRGEYVSRPLNIAQAADR
RDAFVKGIYGHLFLWIIKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NFANEHLQQFFVQHVFTMEQEEYMSENIAWDYIHYTDNRPTLDLLAFKPMSIISLLDEES
RFPQ--GTDITMLQKLNSVH----ANNKAFLKPKNIHD--AHFGIAHFAGEVYYQTEGFL
EKNRDM---LSTDILTLVRSSKNKFLKEIFNLESPQAKLGHGTIRLTTEMK--QL-----
----FKP-SDTTKRPPTLAGQFKQSLEQLMKILTHCQPYFVRCIKPNEYKKPLLFDRELC
TLQLRYSGMMETVRIRKSGFPVRYTFEEFSQRFGMLLRSPERM-QLRDKSRQMSLRIADV
CLGTDKDWKVGRTKMFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTLLEIQRSQALNG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVCIQRLLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 860)

RQ-
--AAVTLQAGWRGYCHRKN

ENSGT00900000140810_6_Linker_4_5 (860, 890)

F-ELILVGFQRLQAIARSLTLARQFQALRH

PF00612 // ENSGT00900000140810_6_Domain_5 (890, 907)

RVVRLQARCRG
YLVRQHVQTKKKAVVTIQALARGMAVRRGIKKQK--------------------------
-----------------------------------D--SLVIPAKE---QKAVPERKR-Q
SIYDTIT--DTEMVEKVFGFLPSMIGGQEGAAPTRFEDLETNTP--RLPEIDLDTVPMVE
G---PEEEVDELNEYTFPKFAMTYFQKSASHTHTQKLLRYPLLYHENDTDHSAALAVWTI
ILRFMGDLPEPVLYARNSLGGG-SVMRQIHDRLGNESRT---------------------
---------QLKRSSRT---TGQVA----SQLSNIGEEAFEPDGPISD-------RPMTN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRPG--LRDEIYCQ-ICKQLSE-NFKKSSLARGWILLSLCLGCF--PP
SERF-MKYLLNFISQGPAGYGPFCAERLRRTYANGVRTEPPTWLELQAVKSKKHVPIQVI
LATGESLTV---TVDSASTSQEI--CMHIAQKRGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAHERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDAVST
ELIYRQILHGVWS-GEYRFEKEEQLVELLARHCYVRFGAT--LRSEAVQELLPSCVPSKL
YKTNSPEKWASLVIATHAK-APYTQQRAAAL-------------------------AVQ-
EQVVDA---AL-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGMYFLDQK-E--RILMELSFPEVMG---------LVAKKE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------APGGQRLLLCTLQEEEYEFVSPSSVAIAEL
VALFLGGLKERSVFAMALKERKATD----DVTLL-AFKKGDLLILTKKQGLLCSE-NWVL
AQNDRTTKTGLVPTSCLYTIPVVTKPPAQLVSLLAMSPEKRKLAAQEWRPSEPHLEEEPA
KETLPTLEDFSYE-FFRAPEKETVSRAMLPLARTRGHLWAYSAEPLRQPLLKRV----HD
KADL-------RDAACQVFLDILP-------PYTGDYPSRQGWHSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2428)

ELTDQIFSLALQDL
DLQDEAYCQILKQL-THNPNRYSEERAWQLLWLCTGLFPPGKSLLPHAQKFIDARRKK-S
LALDCSRRLQKVLRTGPRKQPPHHVEVKTAEQNVSRICHQVYLPNDTSEVSVLDVGSNSR
VRDVCESIATKLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNVTPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDRSQLASVPKILKELVPENLTRLMSSEEWRKN-LLLECEKHKSMAVQ
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLFIHPKTK--------
-----------------------------------------------ELLVTYPFTKISS
WSSGSTYFHMALGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAVSKQRGSRAR
P--------------------------------------

----------------------MSGFRLGDHVWLEPPSTHKTGVAIGGIIKET-KPGKIL
VEDDEGKEHWIRAEDFGVLSPMHPNSVQG

PF00063 // ENSGT00900000140810_6_Domain_1 (90, 180)

VDDMIRLGDLNEAGMVHNLLIRYQQHKIYTY
TGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFNMKRNKRDQCCII

ENSGT00900000140810_6_Linker_1_0 (180, 237)

S
LAT--------------------------------------------------SSE

PF00063 // ENSGT00900000140810_6_Domain_0 (237, 798)

HRFG
KYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYYMLMGMSAEDKQLLSLGT
PSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILHFSDSESWDLSKLLAAILHLGNVGFM
ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLTKHTILIRGELVTRPLNIVQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCI
NFANEHLQQFFVQHVFAMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSVISLLDEES
RFPQ--GTDLTMLQKLNSVH----ANNKAFLQPKNIHD--ARFGIAHFAGEVYYQAEGFL
EKNRDV---LSTDILTVVYSSKNKFLRELFNLESAETRLGHGTIRQAKAGN--HL-----
----FKS-ADSNKRPSTLAGQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPIRYTFEEFSQRFGALLPSAVRM-QLRGKFRQMTLGIADM
WLRTDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 815)

KDHQDTLLEVQRSQVLD

PF00612 // ENSGT00900000140810_6_Domain_3 (815, 834)

RAALSIQRVLRGYRY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RR-
--AAVTVQAWWRGYCNRRNF-

ENSGT00900000140810_6_Linker_4_5 (862, 891)

KLILVGFERLQAIARSQQLARQYQAMRQR

PF00612 // ENSGT00900000140810_6_Domain_5 (891, 907)

TVQLQALCRG
YLVRQQ

ENSGT00900000140810_6_Linker_5_6 (907, 911)

VQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRNFQQRK--------------------------
-----------------------------------ANAPLVIPAEGQKSQGALPAKKR-K
SIYDTVT--DTEMVEKVFGFLPAMIGGQEGQAPPRFEDLESKTQ--KLPEVDLDTVPMVE
E---PEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDADCLAALAVWNV
ILRFMGDLPEPVLYARSNQQGS-SVMRQIHDTLGRGHGAQAPQH-RF-------------
---------------------AQVA----SQL-NIGEETLEPDGLGAD-------RPMSN
LEKVHFIVGYAILRPS--LRSVPT------PIPA-PFRASDPLAGS------HVFL--PS
PLLI-YQYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVI
LATGESLTV---SVDSASTSREV--CMHIAHKQGLSDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAIAQCEQLAQERSESQR-----QSPWRIYFRKE--F-FAPWHDSREDPVST
ELIYRQVLHGVWS-GEYSFEKEEELVELLARHCYVQLGAS--AESKAVQELLPSCIPHRL
YRTKPPERWASLVTAACAK-APYAERQATPL-------------------------AVR-
EQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LILAV
NWKGLCFLDQR-E--KTLLELSFPEVMG---------LVANRE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQGRQRLLLSTMH-EEYEFVSPSSVAIAEL
VALFLEGLKERSVFAM

PF07653 // ENSGT00900000140810_6_Domain_10 (2117, 2177)

ALQDRKATD----DATLL-AFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTAC

ENSGT00900000140810_6_Linker_10_12 (2177, 2327)

LYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQLAEPRPEEP-P
KEKPHTLEEFSYE-FFRAPEKDTVSMAVLPLARARGHLWAYSSEPLRQPLLKR----VHA
NVDL-------WDIAST---PIL--------RYMGDYPSRQARPSL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

ELTDQIFTLALQHP
ALQDEVYCQLLKQL-THNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGK-L
LAPDCGRRIQRVLRTGPRKQPPHQVEVEAAEQNISRICHKVYLPNDTSE--MLEVVANTR
VRDVCDSIATRLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVKKNKPQK
E----GAP-VTLPYQVYFMRKLWLNITPGKDVNSDTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAI
HLAGLIYKAQFNNDRSQLANVPKILRELVPKDLTRLMSSEEWKKS-ILLAYDKHKDKTVE
EAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDIILIAINRHGVLLIHPKTK--------
-------------------------------D-----L-----------LTTYPFTKISS
WSSGSTYFHMVLGNLGRGSRLLCETSLGYKMDDLLTS-----YVQQLLSAMNKQWGSKAP
ALASA----------------------------------

----------------------------GDHVWLDPPSTNKTSVAIGGIIKET-KPGKVL
VEDDEGKEHWIQAEDLGALSPMHPNSAQG

PF00063 // ENSGT00900000140810_6_Domain_0 (90, 798)

VDDMIRLGDLHEAGIVHNLLIRYQQHKIYTY
TGSILVAVNPFQLLPLYTLEQVQLYYGRHFGELPPHVFATANSCYFNLRKNKRDQCCVIS
GESGAGKTETSKLILQFLATVSGQHSWIEQQVLE---ANPILEAFGNAKTIHNDNSSRFG
KYIDIYVSPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGMSKEEKKLLDLGT
PSEYHYLTMGNCTSCEGLNDSKDYAHIRSAMKILLFSDSENWDISKLLAAILHLGNIEFM
ASIFENLDSSEVMETPAFPTVMKLLEVQHQPLRDCLTKHTILIRGEHVTRPLNMAQAADR
RDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFQNNSFEQLCI
NLANEHLQQFFVQHVFAMEQEEYRSENLAWDYIHYTDNQPTLDLLALKPMSVISLLDEES
HFPK--GTDLTMLQKLNGVH----ANNKAFLKPKNIHD--ARFGIAHFAGEVYYQVEGFL
EKNRDV---LSTDILTLIHSSKNKFLRQIFNLESAETKLGRGTIRQAKTGS--QL-----
----FKS-TDSAKRPSTLAGQFKQSLEQLMKILTRCQPYFVRCIKPNEYKKPLLFDRELC
LRQLRYSGMMETVRIRKSGFPVRYMFEEFAKRFGVLLPSAQRV-QLRDNFRQMTLSITDL
CLETDKDWKVGKTKIFL

ENSGT00900000140810_6_Linker_0_3 (798, 816)

KDHQDTLLEIQRSQALDG

PF00612 // ENSGT00900000140810_6_Domain_3 (816, 834)

AAVSIQRVLRGYKY-RKE

ENSGT00900000140810_6_Linker_3_4 (834, 838)

FLRQ

PF00612 // ENSGT00900000140810_6_Domain_4 (838, 862)

RQ-
--AAVTLQAGWRGYCNRRNF-KLILLGFERLQAIARSHILVRQFQAMRQRIVQLQARCRG
YMVRQQVQAK

PF00612 // ENSGT00900000140810_6_Domain_6 (911, 931)

RRAVVVIQAHARGMAARRCF

ENSGT00900000140810_6_Linker_6_7 (931, 1264)

QQQK--------------------------
-----------------------------------ASGPVIIPAEEQKDQSALPTKKR-E
SIYDTVT--DTEMVEQVFGFLPSMIGGQEGQAPARFEDLETKTP--KLPEIDLDTVPMVE
E---PEEDTDGLAEYTFPKFAVTYFQKSASHTHIRRLLRYPLLYHDNNTDYLAALAVWTI
ILRFMGDLPEPVLYAKNSLRSS-PVMRQIHSRLGQEGAAEGPQHSGSVQ-----------
-----------------------VA----SQL-STGEEDFDPDGPISD-------RPMSN
LEK

PF00784 // ENSGT00900000140810_6_Domain_7 (1264, 1368)

VHFIVGYAILRSG--LRDEIYCQ-ICKQLSE-NPKASSRARGWILLSLCLGCF--PP
SERF-LKYLLNFIGQGPAGYGPFCAERLRRTCANGVRTEPPTWLELQAVKSKKHIPIQVI
LVTGQNLTI---TVDSASTSREV--CLHIAQKQEITDHLGFSL-----QVAVYDKFWSL-
GSGRDHVMDAVAQCEQLAQERGESQR-----QSPWRIYFRKE--F-FTPWHDSQEDPIST
KLIYRQVLHGVWS-GEYSFEREEDLVELLAQHCHVQLGTS--SGSEAVQGLLPSCIPPKL
YKTKSPEKWASLITAAQAK-APYTKTRATAL-------------------------AVR-
QQVVDA---AR-----------------------------------------LQWPLLFS
RLFEVTTLS-GPRL----------------------------------------------
----------------PKTQ----------------------------------------
-------------------------------------------------------LVLAV
NWKGLHFLDQR-E--RTMLELSFPEVTS---------LVTNRG-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------AQRGQRLLLSTLQGEEYEFTTPSSVAIAEL
VALFLEGLRERSVFAMALQDRKATD----DIALL-PFKKGDLLVLTKKQGLLASE-NWTL
GQNDRTGKTGLVPTACLYAIPTVVKPSPQLLSLLAMSPEKRKLAAQEG-PSEPLPEEQ-P
KEKPHTLEEFSY-EFFRTPEKETVSRAVMPLGRTQGHLWSYSLEPLRQPLLKHV----HD
KADL-------RDVACQIFLAIL--------KYTGDYPSRQTWPTL

PF00784 // ENSGT00900000140810_6_Domain_12 (2327, 2429)

QLTDQIFSLALQEP
ALQDEVYCQILKQL-THNSNRHSEERGWQLLWLCTSLFPPGKALLPHVQKFIDTRRKK-K
LAPDCSRHIQRVLRTGPRKQPPHQVEVEAAEKNVSRIFHKVYFPNDTSE--MLEVGTNNR
VREVCEAIATKLQLASWEGCSLFIKIADK---VISQKEGDFFFDSLRQVSDWVRRNKPQK
E----GAP-ATLPYQVYFMRKLWLNVVPGKDVNADTI

PF00373 // ENSGT00900000140810_6_Domain_14 (2558, 2661)

LHYHQELPKYLRGFHKCSREDAV
HLAGLIYKAQFDNDQSQLASVPKILRDLVPENLIRLMSSEEWRKS-LLPECSKHQNKTVP
EAKVAFLKYICRWPTFGSAFFEVKQASEPSYPDIVLIAINRHGVLLIHPKTK--------
-----------------------------------------------ELLTTYPFTKLSS
WSSGSTYFHMALGSLGRSKRLLCETSLGYKMDDLLTS-----YVEQLLNVMNKQRGSRAP
APATP----------------------------------