Query Results 

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-----------------MEKA-VLA-AAVRNTKER-QNVEGPFMD-----I--ETRRVEK
CS--LIKTFR-LK------A-----------------GNQ---------TMDI---LCTT
IQKES-------LGG-------AVAFISYASI-----GSII-NESFVSE--------ENL
MTKEKLHN-----------------FYLNSKV-VSGTVGSR---KNTS-LSMS-INFT--
-----F-QHEK------------------I-KR-ENE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

QPL-CVY--WQ------GSSWSN
E-GCQVI-SSDE-NQT-VCSCSH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAS---TK--LQVD----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTMITYVGLSLSLLCLFLAALTFLLCRPIQNT-STSLHLQLSICLF
LAHLLFL-TGINQTKP-------K---VLCS---IIAGTLHYLYLASFTWMLFEGLQLFL
TVRNLRVANYISA-GKFKRRFIYPFGYGIPAVIVAVSAGVGHSNYGTH---TH-CWLSF-
-H------GKFIWSFMGP----VFVIAL--------------------------------
-----INLSFYLTTLYIL-KDQLSSLNNEVSR-M--HNT--RMLTFKAIAQLFILG--CS
WSI-GFFL-VEGVLDPIRSIVAYSFTIINVLQGVYIYLVYCLLNHKVRE--EYRNWFKKM
KKRTE-TN-NYDL-------FG-SVTHTR-MMEKT-VGF---------------------
PGK--------SSNLSSWHNVTHTPDSSSCFPESKKEEE---------------------
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----------------

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---------MDCG--PH---GVPWNLSHCVCE----EGF--RAISGKAPFRGTS-ETGC-
EGFTK----------GK------------------DYMKRCLNG----------------
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----------------------SQQETAAS--FRHVLV---------------DSSLWS-
MESREEVASAATLLLQSLGSA-AVT-AALAAPENQTQTATTKL-------MAIPTKLTDE
NCSRQSDILQ-LT------A-----------------HGD---------SLEI---DCTA
VTAAD-------TKG-----PAAVAFLSYTGL-----ESLL-GGRFLQD--------ENP
GSEARPEQ-----------------FRVNSRV-VSASTSNW----RKN-ISRP-INLT--
-----F-LHLE------------------D-KP-LLDR

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

AI-CVH--WDST--GQDAVWSP
Q-GCQNL-HSNV-THT-RCRCHS-LT----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAP---GL--IQVD----FA---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LFVISQTGLIISLICLVLAIVTFLFCRPIRNSHSTFLHLQLSLCLF
LADLLFI-AGIDKTYN-------Q---LACS---ITAGLLHYLFLASFPWMLLEAVSLYL
IVRNLKVERYASL-GTGMRKYMYAFGYGLPAAIVTVSAASAPNSYGTP---YH-CWLNP-
-E------NGFRWHFLGP----VCAVVV--------------------------------
-----INLGFFCLTMKLL-QEHLSSLNAELST-L--RSTSLRSLTFKALAHLLVLG--LT
WGL-GTFQ-FGP----LATVMGYLFTITNSLQGAFIFMVHCLLNQKVRA--EYWKWFKRL
RRSKE-ESSSSKI-------TM-SALPPS-------------------------------
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----------------

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----------MRGPSLLPGLCFLLS-LSEV----MAQKSI---ASC-NCPQHADCV----
------------------------------------------------------------
-----------------------------------------------------------N
STHCTCKHGYTSMHGEEFF-------------------------------T--FPLATCE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECKPPI-SIYCGENAACQN-TDGGFYCHC-------NPGYKLLSGA--PQFQNPNEN
TCQKATSSATTKAMKD--------------------------------------------
--------------------------V------S--T-----------------------
-----------------------------------------SPALEPSQ-LQR-------
-VVETF----------------------------ESLLANK-TLLGTG------------
--------------------------------------------------EKEKVASW-A
TGVLQTL--E------T----------------------------DA-------L-----
----------------DTAL-------KSP-EQKIQ----------KI------------
----------HNS-TVAIETRVVTD-------NCS-------------------------
---EEEQIFS-LN--TH-----------------------M-------NSVDI---HCND
VVQGN-------IQG-----PTAIALISYSSL-----GNI--INATF-FE---------E
SN--EKDRVY-----------------LNSEV-VSAAIGPQ---RNKS-LSKS-VILS--
-----F-QHVK------------------M-KP-NKGKVF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVY--WKST--GDHGQWSR
D-GCFLI-QENK-THT-VCNSTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAL---TS--QEKD----PG---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LTVITYVGLGISLLCLLLAALTFLLCKTIQNT-STSIHLQLSICLF
LAHLLFL-TAIDQTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSV-SKIMKKLMFPVGYGVPAVIVAISAVIKSDLYGTPD---R-CWLNL-
-D------QGFIWSFLGP----VCAIIC--------------------------------
-----VNLVIFLLILWIL-KRKLSSLNSEVST-I--QNI--RMLTLKATAQLFILG--CT
WFL-GILQ-VGP----AAHVMAYLFTIINSLQGVFIFLVYCLLSQQ------VRKWFGEI
TKSKS-ESEAYTL-------ST-KFGADS-KPSESK------------------------
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----------------

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--------------FPVPGLCFLLS-LSVV----MDQKTT---ASC-NCPQHAYCV----
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-----------------------------------------------------------N
DTHCTCEHGYRSDFEQQFF-------------------------------T--FPLTTCQ

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1064)

DINECDPPI-SIYCGANAACKN-VDGGFHCRC-------NPGYKLLSGD--TQFQNSNEN
TCQKTTSSATTKDMKD--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQH-------
-VVETF----------------------------QSLLTNN-TPLGTG------------
--------------------------------------------------EKGAVATW-A
TEVLQTV--E------S----------------------------AA-------L-----
----------------ETAL-------KSP-EHKIQ----------EI------------
----------HNN-TVAIETRVVTD-------NCS-------------------------
---EEGQMFS-LN--TH-----------------------M-------NSVDI---HCND
IVQGN-------IQG-----PTAIAFISYSSL-----GNI--INATF-FE---------E
AN--ERNQVY-----------------LNSEV-VSAAIRPQ---RNLS-LSKS-VILS--
-----F-QHVK------------------R-KP-GT

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

RKAF-CVY--WKSS--GERGQWSR
D-GCFLM-QVNE-SHT-ICSSTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

VAF---TS--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PL---
--------------LAVITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSA-SRVMKKLMFPVGYGAPAIIVAISAASRPHLYGTRD---R-CWLNL-
-D------QGFIWSFLAP----VCAIIC--------------------------------
-----VNLVIFLLILWIL-KRKLSSLNSEVST-I--QNI--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIVKSLQGVFIFLVYCLLSQQQLSHLQVRKWFGEI
MKFKS-ESETYTL-------ST-KFGADS-KPSEGVV-----FP----------------
-----------ELVKRKY------------------------------------------
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----------------

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-------------MGS----------RCLL--VLLSGLTVL-------------------
----------------------------LALPG-SEA-----KNSGASCPPCPKYASCHN
S-THCTCEDGFRARSGRTY-FHD-SS-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1065)

DINE-----------C-------------
------------------------------------------------------------
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------ETG-LAKCKYKAYCRN-KVGGYICSC-------LVEY-TLF-------------
-----NFL------AGI---------------------------------IDYDH-----
---------------------------PDCYENN----------SQG-TT-Q--------
------------------------------------------------------------
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----------------------------SN--VDIWENLRR-------------------
NGSREDFARRATQLIQSVELS-IWN-ASFAS---P-GKGQISEFD-----IVYETKRCNE
----TRENAF-LE------A-----------------GNN---------TMDI---NCAD
ALKGN-------LRE-----STAVALITYQSL-----GDIL-NASFFSK--------RKG
-----MQE-----------------VKLNSYV-VSGTIGLK---EKIS-LSEP-VFLT--
-----F-RHNQ------------------P-GD-KRTKHI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WEGS---EGGRWST
E-GCSHV-YSNG-SYT-KCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VAL----A--PKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITQVGLTISLLCLFLAILTFLLCRPIQNT-STSLHLELSLCLF
LAHLLFL-TGINRTEP-------E---VLCS---IIAGLLHFLYLACFTWMLLEGLHLFL
TVRNLKVANYTST-GRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTF---TH-CWLKL-
-D------KGFIWSFMGP----VAVIIL--------------------------------
-----INLVFYFQVLWIL-RSKLSSLNKEVST-I--QDT--RVMTFKAISQLFILG--CS
WGL-GFFM-VEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRM--EYKKWFSGM
RKGVE-TE-STEM-------SR-STTQTK-TEEVG-KSS-EIFHKGGTASSSAESTKRPQ
PQV--------HLVSAAWLKMN--------------------------------------
------------------------------------------------------------
----------------

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---------------------------------------MWGFWLL--------------
LFWGFSGMNRWG--MTTLPTLGQRLH-----------GVNECQDTTTCPAYATCTDTTD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCT-CKRGFLSSNGQ--TNFQGPGVECQDVNECLQS-----------------------
------------------------------------------------------------
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------------------------------------------------------------
DSPCGPNSVCTNILGRARCSCLSGFSSSTG--KDWILGSSDHFLCADVDECLT-TGICPK
YS------------------------NCS---NSVGSYSCT-------------------
--CQPG-------------FVLNGS---------ICE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DEDECVTRDVCPEHATCHNTLG
S-YYCTCNSGL

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ESSGGGPM-FQG--LDESCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECSR---NS-TLCGPTFICINTLGSY
SCSCPAGFSLPT--FQTLGHPAD-------------------------------------
--------------------------------------------------------GNCT

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1067)

DIDE----C-DDTCPFNSSCTN-TIGSYFCTC-------HPGFASSNGQ--LHFKDLD--
-----------------------------------------------VTCE---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1336)

DIDECTQDPLQCGLNS--------VCTNVP---GSYICGCLPDFQMD--------PE--
-G-----HG-N-F-NCKR-I----------------------L-FK-C-------K-EDL
---IPQS--E-QI---QQCQAVQ--G---RDL--------GYAS---FC-----------
----------TLVNATFTILDNTCENKSAP--VSLQ---SAATSVSLVLE---QAPTWF-
ELSKEETSTLGTILLETVESTM-LA--ALLISSE------NASQTIQTEYLDIESKVITE
ECKEENESIN-LT------A-----------------RGD---------KMNV---GCFI
IKESV-------STG-----APGVAFVSFAHM-----ESVL-NEQFFEDG--------QS
FQ-----K---------------LR--MNSRV-VGGTVTGE---KKED-FSKP-IIYT--
-----L-QHI---Q---------------P-KQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WNTD-VEDG-RWTP
S-GCEIV-EASE-THTV-CSCNR-MA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGTVISLVCLALAIATFLLCRAVQNH-NTYMHLHLCVCLF
LAKILFL-TGIDKTDN----------QTACA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHLCAFGYGLPVLVVIISAFVQPRGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCMIIT--------------------------------
-----INSVLLAWTLWVL-RQKLCSVSSEVSK-L--KDT--RLLTFKAIAQIFILG--CS
WVL-GIFQ-IGP----LASIMAYLFTIINSLQGAFIFLIHCLLNRQVRD--EYKKLLTRK
TDLSS-HSQTSGI-------LLSSMPSTSKMG----------------------------
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------------VLLALLGLEVK-----------------------------NSGAVST-
HSQRTD--F-CPPCLENAICPN-S---PHCSC-------EGEFESMSGK--KYFIKPF--
-----------------------------------------------EKCE

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1166)

DNDQCNST-
LENCAPKTYCINIDGFF-NCSCVIEYP---T-FK--WAYSI---TLR-------------
---------------------------------------------------------NT-
NS----------------------------------------------------------
---------------------------------------------------------KNE
---THKN--K-T-------QNKT-------------------------------------
----------------------KTTK--NK--KKKQ---KTAESFGGVLK---QSHTWS-
EFTKEETSSLATVLLESVESIT-LA--AFLKPSV------NACQTIQTEYLDIESKVIKE
ECIGENISFN-LK------A-----------------KGD---------AMKI---GCST
VELGE-------ISG-----TTGVAFASFEGM-----ESVL-DERFFQDP--------QD
PLANSKRK---------------LK--MNSRI-VRGIMTGE---KKDG-FSDP-VYYT--
-----L-QNN---Q---------------P-KQ-KFE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

RPI-CAS--WDTD-VDGG-RWIA
S-GCEVL-DASE-THTV-CSCKR-LA----NL-AII-

ENSGT00900000140800_1_Linker_21_22 (1838, 1856)

MA-S--ME--LTME----

PF00002 // ENSGT00900000140800_1_Domain_22 (1856, 2196)

YS---
--------------LSIISHVGLVISLVCLVCAIATFLLCRSIHNR-NTDLHLHLCVCLF
LAKILFL-TGVNRTEN----------KLGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNVKMLHLCAFAYGLPGLVVVVSASVQPKGYGMRD---R-CWLNT-
-E------TGFIWSFLGP----VCTIIM--------------------------------
-----INSTLLTWTLLIL-RQKLSSANAEVST-L--KDT--RLLTFKAFAQVFILG--CS
WVL-GIFQ-IGA----MARVMAYLFTVINSLQGAFIFLIHCLLSRQVRE--EYRRWFTAK
TKLSS-QSQTSGI-------VLSSLHSSSKMG----------------------------
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----------------

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---------------------------------------MWSFSFL--------------
LFWGCCGFYSWV--IFTLSPLESMAQS-----------G

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NECTDTTMCPAYATCTNTSDS
YYCS-CKRGFLST

ENSGT00900000140800_1_Linker_1_3 (434, 450)

NGQ--MQFKDPTVECL

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 485)

DIDECSQSPPVCGPHSICKNLPGRYRCSC--
LTGF

ENSGT00900000140800_1_Linker_3_4 (485, 506)

SSPTGNNWILG--KKGRFICT

PF07645 // ENSGT00900000140800_1_Domain_4 (506, 855)

DVDECANPRACPEHASCR-----------------
------------------------------------------------------------
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--------------------------------------------------------NSVG
S-YSCVCKSGFESSTGKMG-IQG--PGETCRDIDECSQ---SP-PACGPHSVCRNLPGSYKCSCLPGFSSPTGDDWIPAKGGRFACV-DI--------NECLQS--GVCPEHSQCTNSLGSYSCSCHVGFT------------------------------------------STNSICEDVDECA--N-PRACPEHASCRN-SVGSYSCVC-------KSGFESSTGK--MGIQGPG-------------------------------------------------ETCRDVDECSSN-STLCGPSSVCTNLPGKY-SCSCLPGFFSPGVWSP--E---KPEAFKC------------------------------------------------------------------------------------------------------------------------------------------------------TGV----------------------P-FK-C-------K-EDV---MPNN--E-WV---QLCQDGA--A---VKP--------KYVS---FC---------------------AVMNATFSVLDDACKKT-TA--VSLK---NTAERFASVIE---KTFTRS-SFTKEEISTLATVLLKSVESTT-LA--SFLKPSA------NVSQTIQTEYLDIESKVINKGCTEEDETFN-LK------A-----------------KGD---------KMKI---WCSTIKESE-------STG-----ISGVAFVSFEHM-----ESVL-DERFFQDP--------QTPWANSKRK---------------LK--MNSRI-VSGIITGE---KKEG-FSKP-VIYT-------L-ENI---Q---------------P-KQ-NFESPI-CVS--WNTD-GKGG-RWTPS-GCVTL-EASE-THTV-CSCNQ-MV----NL-AVI-MA-S--GE--LTME----FA-----------------LFVISHVGTIFSLVCLAVAIITFLLCRTIRNH-NTYIHLHLCVCLFLANLLFL-TGADKTHH----------QIGCA---IIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSS-HNIKMLHLCAFGYGLPGLVVFVAANIHPQGYGMYN---R-CWLNT--E------KGFIWSFLGP----VCTII

PF07645 // ENSGT00900000140800_1_Domain_6 (506, 855)

DVDECANPRACPEHASCR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSVGS-YSCVCKSGFESS

ENSGT00900000140800_1_Linker_6_11 (855, 872)

TGKMG-IQG--PGETCR

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DIDECSQ---SP-PACGPHSVCRNLPGSY
KCSCLPGFSSPTGDDWIPAKGGRFACV-DI--------NECLQS--GVCPEHSQCTNSLG
SYSCSCHVGFT------------------------------------------STNSICE
DVDECA--N-PRACPEHASCRN-SVGSYSCVC-------KSGFESSTGK--MGIQGPG--
-----------------------------------------------ETCRDVDECSSN-
STLCGPSSVCTNLPGKY-SCSCLPGFFSPGVWSP--E---KPEAFKC-------------
------------------------------------------------------------
------------------------------------------------------------
-----------------TGV----------------------P-FK-C-------K-EDV
---MPNN--E-WV---QLCQDGA--A---VKP--------KYVS---FC-----------
----------AVMNATFSVLDDACKKT-TA--VSLK---NTAERFASVIE---KTFTRS-
SFTKEEISTLATVLLKSVESTT-LA--SFLKPSA------NVSQTIQTEYLDIESKVINK
GCTEEDETFN-LK------A-----------------KGD---------KMKI---WCST
IKESE-------STG-----ISGVAFVSFEHM-----ESVL-DERFFQDP--------QT
PWANSKRK---------------LK--MNSRI-VSGIITGE---KKEG-FSKP-VIYT--
-----L-ENI---Q---------------P-KQ-NFES

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WNTD-GKGG-RWTP
S-GCVTL-EASE-THTV-CSCNQ-MV----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1875)

I-MA-S--GE--LTME----FA---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LFVISHVGTIFSLVCLAVAIITFLLCRTIRNH-NTYIHLHLCVCLF
LANLLFL-TGADKTHH----------QIGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-HNIKMLHLCAFGYGLPGLVVFVAANIHPQGYGMYN---R-CWLNT-
-E------KGFIWSFLGP----VCTIIV--------------------------------
-----VNSILLTWTLGIL-RQKLSSLNDEVST-L--KDT--RLLTFKAFAQIFILG--CS
WVL-GIFQ-IGP----IAGIMAYLFTVINSLQGAFIFLIHCLLNRQVRE--AYSRCITGK
TKPGS---QTSGI-------SLSSVPSASKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHTGPTLKPT------------TKD

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 435)

NKCRDSTMCPSHATCTSTVDS
YYCA-CKQGFRSSNGQ--NHFKDPGVECK-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 855)

DIDECT--------
------------------------------------------------------------
----------------------------------------------EMCPINSTCTNTPG
S-YFCTCHPGFAPSNGQLN-FTD--QK--VECR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1324)

DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPD--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQDRT--T---VKP--------EYVS---FC-----------
----------AQMNNIFSVLDNVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESLT-LA--AFLKPSA------NVTQTVRTDYLDIESKVINK
ECSEENVN-----------LSLAAK-------------GD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2069)

-LYVISHVGMIISLVCLVLAIATFLLCQSIRNH-ITYLHLHLCVCLL
LAQILFL-AGIDKTDN----------QTGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIAVSKYDNSLAKCVLEEEQGDLRDLEFP----GT
CAAERINSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYKRWITGK
MKPSS-QSQTSSI-------LLSSMPSTSKT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------YVSANLL--------------
IFFKIYFLFIFL--PFPL---LSAIC-----------G

PF07645 // ENSGT00900000140800_1_Domain_1 (399, 434)

VNECSDTTICPTYATCTNTFES
YFCT-CKEGFLSS

ENSGT00900000140800_1_Linker_1_3 (434, 450)

NGQ--TNFRGPGVECK

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 488)

DVDECSQHPPRCGPNSVCTNLPGRYKCSC--
LRGFSSP

ENSGT00900000140800_1_Linker_3_5 (488, 506)

TGNNWISR--KPGRFACS

PF07645 // ENSGT00900000140800_1_Domain_5 (506, 538)

DVNECILSGVCPEHSDCANSMGSYSCTCHAGFIS-
------------------------------------------------------------
----------------------------------------------KNSICE

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 686)

DVDECSQH
PPRCGPNSVCTNLPGRYKCSCLRGFSSPTG--NNWISGKPGRFACSDVNECIL-SGVCPE
HS------------------------DCA---NSMGSYSCT-------------------
--CHAG-------------FISKNS---------ICE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DVEECANPRACPEHASCHNTFG
S-YSCSCNSGF

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ASSSGNLS-FQG--PGGRCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECSR---NL-TLCGPNSVCINIPGKY
NCSCLPGFFSTY--PWTPGKTDVFQCK-DI--------DECSQD-PSPCGQNSVCSNALG
SYSCNCTV-GF--RPSPE--GSW-----------------------------KYGNFSCK
SVNKCS--D-TTICPIYATCTN-TFESYFCTC-------KEGFLSSNGQ--RNFRGPG--
-----------------------------------------------VECK

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1167)

DVDECSQH-
PPRCGPNSVCTNLPGRY-KCSCLRGFSSPTG-NN--WISGKPGRFAC-SDVN-ECIL-SG
V----------CP--EHSDCANSMGSYSCTCH----AGF--ISKN-----------SIC-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1318)

DIDECSQDPSLCGPNS--------VCSNAL---GSYSCNCTVGFRPS--------PE--
-GSWK--YG-N-F-SCKR-I----------------------P-FK-Y-------K-EDM
---IPNN--E-QV---QLCEGKA--A---KEP--------EYAS---FC-----------
----------ELMSTTFGILDDACKNKTTT--ISLK---KMAEHFGTALE---QTHTWS-
SLTKEETSTLATVLLESVESTT-LA--AFRKPSA------NVSQTIQTKYLAIESKIIKE
ECIQENTAFY-FK------A-----------------KGD---------TMKI---GCST
VEESG-------SSG-----TTGVAFVSFEGM-----ESIL-DVRFFQDP--------HF
PLTNSKRK---------------LK--MNSRI-VRGIMTGE---EKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFESSI-CVT--WDTN-VDSG-RWTS
S-DCVIL-NASE-THTV-CSCKR-LG----NL-AII-VA-S--GD--LTME----

PF00002 // ENSGT00900000140800_1_Domain_22 (1856, 2196)

YS---
--------------LYLISYVGLIISLVCLVCAIATFLLCRSIHNR-NTDLHLHVCVSLF
LAKLLFL-TGVDKTDN----------QLGCA---IITGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVANYFSS-RNIKMLHLCVIGYGLPGLVVLVSASVQPKGYGMHD---R-CWLNT-
-E------TGFIWSFLGP----ICTIIM--------------------------------
-----INSVLLTWTLLIL-RQKLSSVNAEVLT-L--KDT--RLLTFKAFAQVFILG--CS
WVL-GIFQ-IGA----MARVMAYLFTIINSLQGAFIFLIHCLLSRQVRE--EYRRWFTAK
TKPSS-QSQTSGI-------ALLSLSSSSRTVRAR-VFA--QAP----------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------THLTF-DGSLVTD

PF07645 // ENSGT00900000140800_1_Domain_10 (814, 856)

-VNE-----CLDTQACPSKATCTDTVG
S-YFCACKSGYESSN

ENSGT00900000140800_1_Linker_10_12 (856, 872)

GKRH-FND-PG-VTCI

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1245)

DK---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------N-EC-----
-----LN-PALCS--PTARCKNTRGSYLCVCN----PGF--ETPDGGTQFTDS--GGTC-INYKQQYRIN--------------------------Y----------------------------------------------------------------------------------------------------------------------------K-----------------------------------------KDAIKLF--LSNFSNITTKP---------------S-QEHKEETARFATQYLDRVQSA-AYE-AALNRPTGGTLRRESQF-------MVIEALTIKNGCKTENEIVK-LQ------I-----------------EKE---------TMDI---DCTIVTGGG-------TGG-----NSAVVFISYKSF-----GSIL-DGSFVSK--------ENLTLDEKLDH-----------------FQLNSKV-ISGTTGCK---KNCS-LAKP-VNFT-------F-HHIQ------------------M-IG-ESKKSL-CVY--WD------ELVWSNE-GCHVT-FSDG-ART-VCSCSH-LS----TF-AVL-MAS---VE--LKED----PV-----------------LTMITYVGLSLSLLCLFLAALTFLLCRSIQNT-STSLHLQLSICLFLAYLLFL-TGIKRTEP-------K---VLCK---VIAGVLHYLYLAAFTWMFLEGLHLFLTVRNLRVANYTSA-GRFKKRFMYPVGYGVPAVIVTVSAAINPQGYGTT---KH-CWINI--E-

PF07645 // ENSGT00900000140800_1_Domain_13 (872, 1245)

DK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-EC----------LN-PALCS--PTARCKNTRGSYLCVCN----PGF--ETPDGGTQFTDS--GGTC-INYKQQYRIN--------------------------Y----------------------------------------------------------------------------------------------------------------------------K-----------------------------------------KDAIKLF--LSNFSNITTKP---------------S-QEHKEETARFATQYLDRVQSA-AYE-AALNRPTGGTLRRESQF-------MVIEALTIKNGCKTENEIVK-LQ------I-----------------EKE---------TMDI---DCTIVTGGG-------TGG-----NSAVVFISYKSF-----GSIL-DGSFVSK--------ENLTLDEKLDH-----------------FQLNSKV-ISGTTGCK---KNCS-LAKP-VNFT-------F-HHIQ------------------M-IG-ESKKSL-CVY--WD------ELVWSNE-GCHVT-FSDG-ART-VCSCSH-LS----TF-AVL-MAS---VE--LKED----PV-----------------LTMITYVGLSLSLLCLFLAALTFLLCRSIQNT-STSLHLQLSICLFLAYLLFL-TGIKRTEP-------K---VLCK---VIAGVLHYLYLAAFTWMFLEGLHLFLTVRNLRVANYTSA-GRFKKRFMYPVGYGVPAVIVTVSAAINPQGYGTT---KH-CWINI--E-

PF07645 // ENSGT00900000140800_1_Domain_14 (872, 1245)

DK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-EC----------LN-PALCS--PTARCKNTRGSYLCVCN----PGF--ETPDGGTQFTDS--GGTC-
INYKQQYRIN--------------------------Y-----------------------
------------------------------------------------------------
-----------------------------------------K------------------
-----------------------KDAIKLF--LSNFSNITTKP---------------S-
QEHKEETARFATQYLDRVQSA-AYE-AALNRPTGGTLRRESQF-------MVIEALTIKN
GCKTENEIVK-LQ------I-----------------EKE---------TMDI---DCTI
VTGGG-------TGG-----NSAVVFISYKSF-----GSIL-DGSFVSK--------ENL
TLDEKLDH-----------------FQLNSKV-ISGTTGCK---KNCS-LAKP-VNFT--
-----F-HHIQ------------------M-IG-ESK

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KSL-CVY--WD------ELVWSN
E-GCHVT-FSDG-ART-VCSCSH-LS----TF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAS---VE--LKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTMITYVGLSLSLLCLFLAALTFLLCRSIQNT-STSLHLQLSICLF
LAYLLFL-TGIKRTEP-------K---VLCK---VIAGVLHYLYLAAFTWMFLEGLHLFL
TVRNLRVANYTSA-GRFKKRFMYPVGYGVPAVIVTVSAAINPQGYGTT---KH-CWINI-
-E------KGFIFSFLGP----ISAVIL--------------------------------
-----INLIFYSITLWIL-RDRLSSLNKDVSK-I--QNT--RMLTFKAIAQLFLLG--CS
WCL-GFFL-AELIKEPLRTIIAYAFTITNVLQGVYIFLVHCLLNQQVRD--EYVKWLRRM
NKKTE-SD-SYIL-------SS-STSQTH-MMEKS----------SNFLEK---------
-----------------------RSNTSV-------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------HSMLLL-LPQGVA---ALN--PGVFRGRRCTFYSTCF----
------------------------------------------------------------
-----------------------------------------------------------G
ASACRCYLGFISPSGEI-F-------------------------------I--NQMVGSK
DIKACDSHM-TVSCGLYADCLN-TKGS-YCMC-------NPGYKLVSEA--ALFRNESKN
KCQDVDECQR-------------------------------------------------K
SLICKGRSICINTEGSY-TCQCPPGLELN----P--EGP-----EPC-K

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1259)

DVN-ECTLGPN
P----------CH--NSTHCLNFVGRYECRCR----LGW--KPIPGSPNGPNDT-I--C-
EXXXXXXXXXXXXXXXX--------XXXXXX---XXXXXXXX--------XXXXXXXXXX
X---------------------------------------XXX-XXXXX-XXXXXXXXX-
------------------------------------------XXXXXXXXXXXXXXX---
----------------XXXXXXXXX--XXXXXXXXXD---LIQEVGDLLE---SPRDLE-
TLPRSEQHFVATNLLFGLE-DV-LRGLSKALPNGP-LTF---------------------
-SSPTGSXXX-XX--XXX-X-----------------XXXXXXXXXXXXXX-X---XXXX
XXXXX----XX--XX-----XXXXXXXXXXXX-----XXXX-XXXXXXXX----------
--XXXXXXXX----XXXXXXXXXXXXXXXXXX-XXXFISNK---NTQN-LSSP-VTFV--
-----F-QH------------------SVI-PG-PR

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QEVF-CVF--WQRG-QNGNGHWAT
K-GCRMV-DTRD-NST-TCQCTH-LS----AF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YEV--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIRNT-STSLHLQLSLCLF
LAHLLFL-TAIDQTQI-------K---VLCA---IVAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYSGV-NRFMKWFMFPVGYGVPAVIVAISAASRPNLYGTPT---R-CWLHS-
-E------KGFKWGFLGP----VCAIFS--------------------------------
-----VNLALFLMTLWIL-KSKLSSLNSDVST-L--QNT--XXXXXXXXXXXXXXX--XX
XXX-GILQ-VGP----AAVM--ALFTIIN-SQGVFIFLVYCLLSQQVRE--QWRKWFKGS
KKTKA-ESEKYML-------SS-GDTSDA--CRRSG------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------CALRCPPNSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTACRCAPGFISFSGEI-F-------------------------------T--DPLESCD
GINECGPPS-PVYCGSSADCQN-TEGGYYCTC-------SPGYEPVSGA--MIFRNESEN
TCRDVDECQH-------------------------------------------------R
PRVCKGLSVCINTEGSY-TCQCPPGLEFS----P--EDP-----RHC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1259)

DVN-ECTSGKK
P----------CH--SSTHCLNSMGSYECRCR----SGW--KPI-GPPNGPHNT-V--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1308)

DVDECSSRQHQCHNST--------VYVNTV---GSYTCHCRQGWEPKPGFWDKQMNTIC
K---------------------------------------EIS-FPTWT-APSGIKSQA-
--------------------------------------------------LSHFLNR---
----------------IQDLGRNFS--SASVLNTVQD---LVQETGDLLE---TPGDLK-
TLPFSEQHFVVTNLLFGLE-NV-LRGVSKALPKGS-FTF---------------------
-NSSAGIELS-LE--VQV-P-----------------SYRNITLIQKQTKM-M---LTWD
TVHDS----GD--SG-----LAVVGLLSTPGM-----DRFL-AEAPLVLD----------
--AEELTTLR----EIHRGLLQETSHILLSDV-ISAFITNK---DTEN-LRSP-VTFV--
-----F-QHVGPD-------GMEWLTQSVT-PG-PREK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VH-CVY--WEHG-QNGSGHWDT
R-GCWVT-STRD-NST-TCQCSH-LS----IF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAH--YSV--QEED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2025)

-LTVITYVGLSLSLLCLLLVVLTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTES-------KVKLVLCA---IIAGALHYLYLASFTWMLLVGLHLFL
SARNLTVVNYSGI-NRFMKKAMFPVGYGVPAVIVAISAASRPHLYG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MAR----------SCFLPW---GGISCL-------------------
-----------------IFFMNIHN-SSFQVSD

PF07645 // ENSGT00900000140800_1_Domain_10 (814, 856)

-VNK-----CLDTRTCPSTSTCTNTVG
G-YYCTCKSGHTSST

ENSGT00900000140800_1_Linker_10_12 (856, 872)

GEKH-FNS-SG-VTCL

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1065)

DKDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KN--SSICPPTAKCKN-TPGSYYCLC-------NPGFVSTD-------------
-----GRDRFTGSGATC---------------------------------IGINPIS-A-
V---P----------------TQSTFSGDCRQQD----------QKN-SK-R-ICS----
-----D---------------------------------------------LE-------
-------EIKS-----V------------------FE-----------------------
------------------------------------------------------------
-----------------------------------------GRNGT--------------
----------------L-----SLKEVANS--YPEVSNILNES---------------S-
LRSKEETNFLAKHYLQSVESA-AYK-AALEQPTEGTVNVQSSYMA-----I--KALTIKN
GCQEENVTFN-IQ------T-----------------EKA---------SMEI---DCTV
ITGGG-------TRG-------AVVFISYDSI-----GPIL-DGSFVAK--------ENL
VLDENRNR-----------------FQLNSKV-ISTSIGCM---EKCS-LTIP-VNFT--
-----F-QHIQ------------------M-LE-ESQK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PV-CVY--WD------ETVWSN
E-GCQNI-FYDR-NHT-ICSCSH-LS----TF-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VAS----V--ELEEIQKDPV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYLGLSLSLLCLLLAALTFLLCRPIQNI-STSLHLQLSICLF
VAHLLFL-IGIDRTEP-------K---VLCS---IIAGVLHYLYLAAFAWMLFEGLHLFL
TVRNLKVANYTSA-GKFKKRFIYPLGYGIPAVIVAVSAGLKPHGYGTP---TH-CWISL-
-Q------EGFIFSFLGP----IAAVIL--------------------------------
-----MNLVFYLVTLWIL-RDRLSSLNKEVSK-I--QNT--RMLTFKAIAQLFLLG--CS
WCL-GLFL-VEVVKEPFISIIAYAFTITNVLQGVYIFLVHCLLNQQVKA--EYIKWFRAM
NKATR-FD-ISTV-------SA-TTTHTQ-EMEKS-SY----LPRSSSNTSL--------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------M----ASS-------------VAGLTG-------------VCTMRH-
-G-----HPRLLP----GLLMLLLL-PLGA----AAQK---TSGCARWCPPKSTCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATTCRCSPGFSSLSGE-IF-------------------------------S--SPLESCD
DIDECGPPP-LVSCGRLADCQN-TEGSYHCMC-------SPGYALASGA--TTFMNESEN
TCRDVDECQLKPRV----------------------------------------------
---CKSRGICTNTKGSY-TCKCPPGFELNL------GDL-----NLC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1259)

DVN-ECTSGQN
P----------CH--NSTHCLNNIGGYECRCR----PGW--KPVPGSPNGPKST-V--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1309)

DVDECSSGKHTCHYST--------VCINTV---GSYKCRCRRGWKPKPRFQDRQLNT-T
C----------------------------E-------VPAEMS-FPTWT-PPPGIKSQ--
-------------------------------------------------RLSNFFER---
----------------VQELHRDFK--PALAQETIQD---LIQEVDELLE---IPGDLE-
ALPHSEQHCVATNLLVGLE-GV-LRNVSQAMPNGP-WTF---------------------
-NASAGTDLS-LE--VQE-E-----------------GYRNVTLSQNLAKM-M---LKWD
VVHKS----GD--SG-----PSVVGLLSTPGM-----GKLL-AEAPLVLE----------
--PEKQAVLH----GAPKGLLQGVSSVLLSDV-ISVFMSNK---VTQK-LSSP-VTFI--
-----F-SHHS-AT-----------------HE-PKLKVF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVF--WEHS-QDECGHWST
R-GCTVV-DSGD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAH--YDV--QEED----LV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LPVITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLLICLF
LAHLLFL-MAIDRTEI-------K---VLCS---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLMVVNYSSV-SMLMKKLMYPVGYGVPTLIVAISAASRSHLYGTRT---R-GWLNP-
-E------ERFIWSFLGP----VCTIFS--------------------------------
-----VNLGFFLMTLWIL-KSKLSSLNSDVST-L--QNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--EYGKWFKGI
RKTRA-ESEKYTL-------SS-RAMSDV--NKPMM------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------CNPRCPLNSECV----
------------------------------------------------------------
-----------------------------------------------------------S
ATACRCKPGFASSSTEI-F-------------------------------T--DPLEICE
DINECVPPM-KVSCGKFADCHN-MEGSYYCMC-------SPGYGLLSGA--KKFTNASEN
TCQGKRHSDLFPML--------------------------------------AAAGMSPA
PSGAHKDSAIWNTPGP-------PSLHGP-------RDP-----VGK-FRRK--------
------ETR

PF07645 // ENSGT00900000140800_1_Domain_15 (1210, 1259)

GPCH--KSAHCLNQVGSYQCRCR----PGW--KPVRGSPNGLKNT-V--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVDECSSGKHQCHQST--------ICTNTL---GSYQCHCRPGWELIPGSVNGRNSTIC
KGTQPAL----------------------------------------TP-EPPPPHTC--
-------------------------------------------------SLSHFFDK---
----------------VNNLHRDFK--PDQANETIQG---IMQEVDVLLE---TPGDLE-
TLPPSQKHCVATHLLTGLE-SA-LRHLSRGLPEGT-ATF---------------------
-NYSAGTQLS-LE--VQE-R-----------------GDGNVTLSLNQAKM-Q---LNWN
LAQES----GY--TG-----PSVVGLVSTPGM-----DKLL-AEAPLVLE----------
--PEKQVVPH----GTHKDLLPRVSSVLLSDV-VSAFLSSN---DTQN-LSSP-VTFT--
-----F-SHPL-VT-----------------PA-PRHELL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WDHS-QNGCGHWAT
E-GCRTA-GTGD-GST-TCHCTH-LC----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VVH--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSIITCVGLGMSLLCLVLAALTFLLCRAIQNT-STSLHLQLSLCLL
LAHLLFL-MAIERTQP-------K---VLCA---VTAGALHYLYLASFTWMLLEGLFLFL
TARNLTVLSSSSR-NRLMRKLMFPVGYGVPAAIVAMSAAARPHLYGTPA---R-CWLNP-
-E------QGFVWGFLGP----VCAISC--------------------------------
-----VNLVFFLMTLWIV-KSKLSSIDSDVST-L--QNM--RVLTFKAIAHLFILG--CT
WCL-GVLQ-VGS----LAPVMAYLFTIVNSLQGVFIFLVYCLLSQQVRE--QYRTWLKKI
WKWTT-EPESYTL-------SS-KAVSNT--SRPSTVGSLPA-P----------------
-----------RAHVPWYLQDFSPPVHRPCFPCLLDSTIM----------PACALTLHDS
LSLPPI---------------------HLLPSYYHSVP---------------TPIRVS-
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------NECLDTTTCPAYATCTNTLES
YYCT-CKRGFLSSNGL--THFRGPGVACE

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 491)

DIDECSQNPPPCGPHSVCRNLLGRYKCSC--
VPGFSSPTGN

ENSGT00900000140800_1_Linker_3_4 (491, 506)

DWVLG--MPGRFSCT

PF07645 // ENSGT00900000140800_1_Domain_4 (506, 816)

DINEC------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------LS-TGVCPE
HA------------------------ECI---NSLGSYSCS-------------------
--CQVG-------------FISHNS---------VCK-DVDECADPGICPEHATCRNSPGS-YSCVCNPGFESSSGNTN-IQG--PGETCEDVDECAR---NS-TLCGLSSVCINILGRYNCSCLPGFFSPA--VWTPEKPEDFRCV-DI--------DECLH-----------------------------------------------------------------------------------------MCPSNATCTN-TPGSYFCTC-------SPGFAPSNGQ--LSFTGQE-------------------------------------------------VECR----------------------------------------------------------------------------------------------------------------------------------DVDECSQDPSPCGPNS--------VCTNVL---GSYGCSCPGGFEPN--------PE---GSL------N-F-SCKR-I----------------------P-FK-C-------K-EDV---IPNN--E-WV---QLCQVGG--A---VEP--------EYGS---FC---------------------ALLNTTFGVLDDACGNRTAT--VSLK---NTVESFASVLE---QTSTWS-NFTKEETSALATVVLESVKSTT-LA--AFLKPSA------NASQTVRTERLEIESKIIKEECTEENVTFH-FK------A-----------------KGD---------TMEI---GCSTIEESE-------SRG-----TIGVAFASFSGM-----ESLL-DDSFFQDH--------GTPSANSQRK-------------------LKSRV-VQGIMTGA---KKAG-FSEP-VIYT-------L-ENT---E---------------P-KQ-EFERPI-CVS--WDTD-AEGG-RWMPS-GCVVL-EASE-THTV-CSCYQ-MV----NL-AII-MA-S--RE--LTRD----FS-----------------LYIISHVGVITSLVCLVLAIATFLLCRAIRNQ-NTYLHLNLCICLFLAKTLFI-VGVDKTDN----------QMGCA---IIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSS-RNIKMWYLCAFGYGLPVLVVAVSASVQPKGYGMHN---R-CWLNL--E------AGFIWSFLGP----VCTIIT-------------------------------------I

PF07645 // ENSGT00900000140800_1_Domain_6 (506, 816)

DINEC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LS-TGVCPEHA------------------------ECI---NSLGSYSCS---------------------CQVG-------------FISHNS---------V

ENSGT00900000140800_1_Linker_6_10 (816, 819)

CK-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 870)

DVDECADPGICPEHATCRNSPG
S-YSCVCNPGFESSSGNTN-IQG--PGET

ENSGT00900000140800_1_Linker_10_11 (870, 872)

CE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 926)

DVDECAR---NS-TLCGLSSVCINILGRY
NCSCLPGFFSPA--VWTPEKPEDFRCV-DI--------DECLH-----------------
------------------------------------------------------------
------------MCPSNATCTN-TPGSYFCTC-------SPGFAPSNGQ--LSFTGQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1336)

DVDECSQDPSPCGPNS--------VCTNVL---GSYGCSCPGGFEPN--------PE--
-GSL------N-F-SCKR-I----------------------P-FK-C-------K-EDV
---IPNN--E-WV---QLCQVGG--A---VEP--------EYGS---FC-----------
----------ALLNTTFGVLDDACGNRTAT--VSLK---NTVESFASVLE---QTSTWS-
NFTKEETSALATVVLESVKSTT-LA--AFLKPSA------NASQTVRTERLEIESKIIKE
ECTEENVTFH-FK------A-----------------KGD---------TMEI---GCST
IEESE-------SRG-----TIGVAFASFSGM-----ESLL-DDSFFQDH--------GT
PSANSQRK-------------------LKSRV-VQGIMTGA---KKAG-FSEP-VIYT--
-----L-ENT---E---------------P-KQ-EF

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

ERPI-CVS--WDTD-AEGG-RWMP
S-GCVVL-EASE-THTV-CSCYQ-MV----NL-AII-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MA-S--RE--LTRD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-FS---
--------------LYIISHVGVITSLVCLVLAIATFLLCRAIRNQ-NTYLHLNLCICLF
LAKTLFI-VGVDKTDN----------QMGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMWYLCAFGYGLPVLVVAVSASVQPKGYGMHN---R-CWLNL-
-E------AGFIWSFLGP----VCTIIT--------------------------------
-----INSILLTWTLCVL-RQKLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGA----IASIMAYLFTIINSLQGTFIFVIHCLLNRQVRE--EYRRWITRK
IKPSS-ESQTSGM-------LLSSVPSTSKTV----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MQGPLL---LPGLCFLLS-LYGA----VTQKTK---TSCAKCPPNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NTHCTCDHGYTSGSGQKLF-------------------------------T--LPLETCN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1081)

DINECIPPY-SVYCGFNAVCHN-VEGSFYCQC-------VPGYRLHSGN--EQFSNSNEN
TCQDTTSSKTTQGRKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDKL----------------------------ESLLTNQ-TLWRTE------------
--------------------------------------------------GKQEISST-A
TIILRDV--E------S----------------------------KV-------L-----
----------------ETAL-------KAP-EQKVL----------KI------------
----------QND-SVAIETQVITD-------NCS-------------------------
---EERKTFN-LN--VQ-----------------------M-------NSMDI---RCND
IIQGD-------TQ----------------------------------------------
------------------------------------------------------------
-----------------------------M-NP-STKKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKST--GQGSQWSR
D-GCFLI-HMNK-SHT-MCNCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---TS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYVGLSVSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-VGIDQTEP-------K---VLCS---IIAGALHYLYLAAFTWMLLEGVHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTAD---R-CWLHL-
-D------QGFMWSFLGP----VCVIFS--------------------------------
-----ANLVLFILVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GLLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREI
VKSKS-ESETYTL-------SS-KMGPDS-KPSEGDV-----FP----------------
-----------GQVKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------CLSLFPVPGLCILLT-LSGV----MIQKAN---CACPPCPQNAVCV----
------------------------------------------------------------
-----------------------------------------------------------D
GTNCTCNSGYTSQSGKKFF-------------------------------T--YPLEICQ

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DTDECKPPI-SVYCGLNAECQN-VPGSFYCQC-------DPGYKLLSGN--TQFKNSNEN
TCQNITSSSTTKGNKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQR-------
-VVENF----------------------------ESLRTNT-TLWESG------------
--------------------------------------------------EEREVASK-A
TSILQTM--E------S----------------------------NV-------L-----
----------------ETAL-------NAP-DQEIQ----------KL------------
----------QNN-TVAVETRVVTD-------NCS-------------------------
---KERNIFN-LN--AQ-----------------------M-------NSLDI---HCND
IIQGN-------LQG-----PSAVVFISYSSL-----GNI--INATF-FV---------E
IN--EEDRIY-----------------LNSQV-VSAAIGPK---RNTS-LSRP-VILS--
-----F-QHVK------------------M-KP-LS

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

KKVF-CVF--WKST--GEDSHWSR
D-GCFLV-QVNK-SHT-TCRCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAF---TS--KEKD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYMGLSLSLLCLFLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEN-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSV-SRFMKWLMFPVGYGVPAVIVAISAASRPHLYGTPE---H-CWLHL-
-K------QGFIWGFLGP----VCVIIC--------------------------------
-----VNLVFFLLVLWLL-KKKFSTLNSEVST-I--QNT--RMLTLKAAALVLILG--CT
WCL-GILQ-VGP----AERVMGYLFTIINSLQGVFIFLVYCLLSQQNEK--YVRKWFGNI
MKPKS-ESETYTL-------SS-RFGPDS-KHN-AGNI----FS----------------
-----------GQVKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------SCPE

PF07645 // ENSGT00900000140800_1_Domain_3 (451, 487)

INECSQVPQPCGPNTYCLNHQRSFSCMC--
EPGYRSSKGDSWLPG--SVAPLNCSDIDECS-----------------------------
------------------------------------------------------------
--------PVPSVCDLHSSCVNTVGSYSCQCQPGYS-SPGA-------LCSQ

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 686)

DIDECSQN
SSICGLHSSCVNTLGNYSCQCKAGHSSPGG--NSWKPGDNHTLNCTDIDECSQNSSICGL
------------------------HSSCV---NTLGNYSCQ-------------------
--CKAG---------HSS-Y----K-CLCQ

PF07645 // ENSGT00900000140800_1_Domain_10 (811, 852)

DID-EC------SQNSSICGLHSSCVNTLG
N-YSCQCKAGH

ENSGT00900000140800_1_Linker_10_11 (852, 872)

SSPGGNS-WVMG-AE-SLGL

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 911)

DIDECSQ---NS-SICVLGSFCVNTAGSY
SCRCHLGYSSPGGNSWKPDDSHTLNCT-DI--------DECSQN-SSICGLHSSCVNTLG
NYSCQCKAGHSSPGGNS-------------------------------------CFFKQN
YIDECS-PV-PSVCDLHSSCVN-TVGSYSCQC-------QPGYSSPGGN--SWKPDDS-H
---------------------------------------------SLNCTV

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1169)

DIDECSQNS
-SICGLHSSCVNTLGNY-SCQCNTGYSSPGGNSWKPGENHS---LNC-TDID-ECS----
-----QN-SSICG--LHSSCVNTLGNYSCQCK----AGH--S--------------SPG-
F

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1313)

DIDECSQNSSICGLHS--------SCVNTL---GNYSCQCKAGHSSPGGNSCILNIT--
---------------------T-----------------DKIP-FSCLQ---------LL
VTGGDDI--G------LCRIH-----------------LQGIQESKKFC--S--------
-----------FMKDIRERWSSALGNGSNP--VPLQN---ATASFDSFVG---DISELP-
PK---EKVLAATVFLKSVESV-AFE-AALRSPMNQ-------IKPIRTGMMTIAAKAVKD
NCSSQGESIS-LN------A-----------------KNE---------WMAI---DCTT
VVGSD-------RSG-----TGAVVFIVYDQL-----ESVL-KDSVSDQ---------SL
TGAERLNE-----------------VTLNSNV-VSATIGKS---RNLS---RP-FNFT--
-----L-EHKE----------------TT---D-NEE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KSI-CVF--WDVA--GDKGNWSK
E-GCELL-TANS-THT-TCTCDH-MS----IF-SIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

VDR---NA--SQED----GA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSIITHVGLSISLLCLFLAILTFLLCRSLWNV-STSLHLQLCLCLF
MANLLFL-TGMDKAKDK----------IGCA---VIAGLLHYLFLACFTWMFLEGLHLFL
TVRNLKVVNYTSA-SRFKKRYMYPFGYGFPALIVAISAAVNSDGYGST---KH-CWLET-
-D------NGFLWSFLGP----VCLIIL--------------------------------
-----MNCTFFITTLWIL-RDKICSLNSDVST-V--KNT--RLLTFKAVAQLFILG--CT
WSF-GLLP---------GKVMAYLFTIVNSLQGAFIFLVHCLLNRQVRA--EYKRWIQRI
EKPST-RTTTFEI-------SM-SAAPLN-TGIV--------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MDI---NCAD
AFKGT-------LRE-----STAVALITYQSL-----GNIL-NASFFSK--------RKG
-----MEE-----------------VKLNSHV-VSGTIGLK---EKVY-LSEP-VFLT--
-----F-QHHQ------------------P-GD-ERTKHI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WEGS---EGGSWSR
E-GCSHV-HSND-SYT-KCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-LAL----A--PKED----AV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITQVGLAISLLCLFLAILTFLLCQPIQNT-STSLHLQLSLCLF
LAHLLFL-TGINRTEP-------E---VLCS---MIAGLLHFLYLASFTWMLLEGLHLFL
TVRNLRVANYTST-GRFKKRFMYPVGYGIPAVIIAVSAIVGPKNYGTF---TH-CWLKL-
-D------KGFIWSFMGP----VAVIIL--------------------------------
-----INLVFYFQILWIL-RSKLSSLNKDVST-I--QDT--RVMTFKAIAQLFILG--CS
WGL-GFFM-VEEVGKMIGSIIAYSFTITNVLQGVLLFVVHCLLNRQVRM--EYKKWFSGM
QKGVE-TE-STEM-------SR-STTQTK-M-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MGLCFLLS-LSGV----VAQKTK---GTCTHCPQNAFCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATHCTCNHGYRSESKEKYF-------------------------------S--YRFERCE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DVDECKPPI-SVYCGVNAECQN-IIGSFYCHC-------IDGYKLLSGK--AQFNNSNEN
TCQKITPSKTTNSTKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------MQQ-------
-VVEDI----------------------------ESHLTGK-TVLGVE------------
----------------------------------------------------RNFTST-V
TAFLQKV--E------S----------------------------DV-------L-----
----------------KTAL-------KAP-DQKIQ----------KV------------
----------QYS-TVAVETQVVTD-------NCS-------------------------
---KRVILSL-N---AQ-----------------------V-------NSMKI---HCSD
VIQRN-------IKG-----TSAVAFVSYSSL-----GNI--INA-F-FE---------E
MN--EKDQVY-----------------LNSQV-VSAAIEPK---KNTS-LSQP-VILN--
-----F-QHMK------------------V-KP-GVKKIF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVY--WKDT--KEGGRWSK
D-GCALR-QANK-THT-ICSSTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAL---HG--QEED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEN-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSI-NRLMKWLMFPVGYGVPAVIVAISAASRPHLYGTPD---R-CWLHL-
-D------QKFIWAFLGP----VCAIIC--------------------------------
-----VNFVFFVMVFWIL-KRKLSSLNSEVST-I--RNV--KMLTLKATAQLFILG--CT
WFL-GLLQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVMF--QVQKWFGEI
IKSKS-ESEAYTL-------SS-RFGADS-KPS-EGET----YN----------------
-----------HRHSRVV------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------CAPWCPQNSTCI----
------------------------------------------------------------
-----------------------------------------------------------N
ATACRCRPGFSSWSGEI-I-------------------------------T--NPADSCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1064)

DINECEPP-LAVSCGKFVDCQN-VDGSYHCTC-------APGYGLVSGA--TTFRNEIEN
TSQYV-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

PF07645 // ENSGT00900000140800_1_Domain_17 (1263, 1320)

-DECSSGQHRCHNST--------VCVNTM---GSYRCCCRPGWTPLPGFRDNQNTTVC
EE---------------------------------------MS-FPTWT-PPPGIQSQ--
-------------------------------------------------SLSGFFEG---
----------------VQDLRRHFK--PASAQNTVRD---LIQSVDELLK---APGDLE-
TLALPDRHHTVTHLLSGLE-EI-LRTLAKAMPGAS-FTY---------------------
-QSSEGTELS-LV--IQE-Q-----------------GHGNVTLGQSHARM-V---LDWA
MAAGAGPVCLS--AG-----PAVAGILSSPNM-----QKPL-ANASLELD----------
--PERQAELE----ETHDSPLRGIQWRLLSAV-KSVLLSNT---NTTK-LDPK-VTVI--
-----F-SHPSARA-----------------QD-PRGELI-CAF--WKGA-GHGGGHWAT
T-GCRRL-GSRN-GNT-TCLG-L-PG----SM-ASL-VNP--EDV--E--D----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LDVITYVGLSLSLLCLLLAALTFLLCRAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEI-------K---VLCA---LIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSS-------WLMFPVGYGVPAVIVAISAASRPHLYGTST---R-CWLRS-
-E------SGFIWGFLGP----VCAICS--------------------------------
-----VNLAFFLMTLWML-KSRLSSLNSDVST-L--QDT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLRQQVRE--QYGKW----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------LSFS-VTFI--
-----F-NHVM------------------T-PQ-PRKK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VL-CVF--WEHS-RNESGHWAT
T-GCTMV-GTRD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAH--YNV--Q-ED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LDVITYVELSLSLLCLLLAALTFLLCRAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEI-------K---VLCA---LIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSV-SRFMKWLMFPVGYGVPAVIVAISAASRPHLYGTST---R-CWLNT-
-D------KGFIWAFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIV-KNKLSSLSSDVST-L--KNT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIINSLQGVFIFLVYCLLSQQVQQ--QYRRWFKGV
TKTKA-ESEKYTL-------SS-RAMPDA-------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------LR---------------K-
TKRRRDFARSATLLLQTVELS-IWN-ESSSS---P-GKGQNSEFG-----TVYETRRCNE
----TSEKAL-LE------A-----------------GNN---------TMSI---NCTH
AFKGA-------TTG-S---KSVVCLITY--L-----EDIL-NGSFFNN--------KIG
-----MQE-----------------VKLNSHI-VSATIGLK---EKVY-LPEP-IVLT--
-----F-QNTQ------------------P-GG-ARTK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

HI-CVS--WEGL-QEEGGRWST
E-GCSHV-YSDN-SHT-QCKCYH-LA----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MGL----T--HKED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITHVGLTMSVLCLFLAALTFLLCRPIQNT-STTLHLQLSLCLL
LAHLLFL-TGINRTEP-------Q---VLCS---FIAGLLHYLYLAAFTWMFLEGLHLFL
TVRNLKVANYTSM-GRFKKRFMYPVGYGIPAVIVTVSAMIGPQNYGTY---TH-CWLKL-
-D------KGFIWSFMGP----VGVIIL--------------------------------
-----INLVFYFQILWIL-RRKLSSLNKEVST-I--QDT--RVMTFKAIAQLFVLG--CS
WSL-GFFM-VEEVGETVRLVTSYLFTIINILQGVLLFVVHCLLNRQVLM--EYKKWFTGM
WKGVK-TE-STEM-------SQ-TTIHTK-EVRSE-HLE-SL------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--TKKDIVQRTTRLLQKVIVN-TWN-DIFDS---P-RKHENPEIG-----IAYETDRCNE
----TSKRII-LE------A-----------------ENN---------TMDI---DCAH
AFKET-------TRVAG---QKDVALIVYQTL-----GDIV-NGSFFSG--------RKR
-----LQD-----------------VKLNSLV-VSGTNDSE---RRIY-LSKP-VFLT--
-----L-KHTQ------------------P-VG-AR

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

TKLL-CAS--WEGS--KKGGSWST
E-GCSHM-GSNN-SHT-KCQCFH-LP----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAV---IS--KTESVLA

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

DPV---
--------------LAVITSMGLSLSLLCLLLAALTFLLCRPIQNT-STSLHLQLSLCLF
LAHLLFL-VGIDKTEP-------E---LLCS---VIAGALHYLYLASFTWMLLEGLHLFL
TVRNLKVANYTSP-GRFKKRFMYSFGYGIPAVIVAVSACIGHKNYGTD---TH-CWLKL-
-D------KVFVWSFMGP----VAFIIL--------------------------------
-----INLVFYFIILWIL-KTKLSSLNNELST-I--QDT--RVMTFKAIAQLFILG--SS
WSL-GFFM-VEAVGETAGLVIAYMFTIINVLQGVLLFVLHCLLNRQVRM--EYKKWFRRI
QKGVE-ME-STEL-------SH-STAHTK-------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MGGRVFLAFCVWLT-LLGA----ETQD---SRDCARWCPENSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATACRCNPGFSASSE--IF-------------------------------T--SPTEICD
DINECVPPS-KVSCGKSSYCRN-TKGSYDCGC-------SPGYELVSGA--KTFKNESEN
TCQ

PF07645 // ENSGT00900000140800_1_Domain_14 (1084, 1178)

DVDE-CQQ------------------------------------------------N
PRLCKSYGTCVNTPGSF-TCQCLPGFKFK----P--EDP-----KLC-TDVN-ECTFGQN
P----------CH--SSTHCLNNVGSYQCRCR----PGW--QPIPGSPNGPNNT-I--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DVDECSSGLHQCDNST--------VCFNIV---GSYTCRCRPGWEPKHGIPNNQKDTV-
--------------------------------------CEEMN-FPTWT-PPPGVHSQ--
-------------------------------------------------TLSQFFNK---
----------------VQDLDRDFK--TSSAKVTIQS---ILKGLDELLE---APGDLE-
TLPRFQQHCVATHLLDGLE-NV-LRGLSKNLSIGL-LNF---------------------
-SYPAGTEFS-LE--VQK-Q-----------------VDRNVTLRQNQATM-Q---LDWS
LAQKS----GD--P----------------GM-----GKLL-AEAPLVSE----------
--PEKQVVLN----ETHQGLL----PILLSDV-ISAFLSNN---DTQN-LSSP-VTFT--
-----F-SHRS--------------------VI-PRRKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WERG-QNGCGHWAT
T-GCSTM-GTRD-TST-ICRCTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAP--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSLSLLCLLLAVLTFLLCKAIQNT-STSLHLQLSLCLL
LAHLLFL-VAIDRTEH-------E---VLCA---IIAGALHYLYLAAFTWMLLEALYLFL
TARNLMVVNYSSI-NRFTKKLMFPMGYGVPAVIVAISAASRPHLYGTPS---H-CWLQP-
-E------KGFIWGFLGP----VCAIFS--------------------------------
-----VNLALLLVTLWIL-KNRLSSLNNEVST-L--QNT--RMLAFKATIQLFILG--CT
WCL-GVLQ-VGP----AAQVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWSKGF
RKLRT-ESEMHTL-------SS-SAKADT--PKPSTPGTVAQ-A----------------
-----------CNASTL------GGRGGQI------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MMARSIFLPLSGLSCL-------------------
-----------------IFFLNIPN-ASFQVTD

PF07645 // ENSGT00900000140800_1_Domain_10 (814, 856)

-VNE-----CLDTQACPSKATCTDTVG
S-YFCTCKSGYESSNGKRH-FND-PG-VTCIDKNE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
-------LN-STACPLTATCRN-TRGSYLCVC-------NPGFETPDGR--AQFTGS---
-------------RGTC---------------------------------IDKNECL-N-
STACPLTATCRNTRGSY-LCVCNPGFETPDRRAQFTGS----R-GTC-I

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1245)

DKN-EC-----
-----LN-PALCS--PTARCKNTRGSYLCVCN----PGF--ETPDGGTQFTDS--GGTC-
IRINPRSPIPTQVTFSE------------------DY-----------------------
------------------------------------------------------------
-----------------------------------------KQQGTTK------DPNTPV
---T---MVTKG-VPEDNNVTLVLQEIADS--FGNFSNITTKP---------------S-
QEHKEETARFATQYLDRVQSA-AYE-AALNRPTGGTLRRESQF-------MVIEALTIKN
GCKTENEIVK-LQ------I-----------------EKE---------TMDI---DCTV
VTGGG-------TGG-------AVVFISYKSF-----GSIL-DGSFVSK--------ENL
TLDEKLDH-----------------FQLNSKV-ISGTTGCK---KNCS-LAKP-VNFT--
-----F-HHIQ------------------M-IG-ESKKSL

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WD------ELVWSN
E-GCHVT-FSDG-ART-VCSCSH-LS----TF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAS---VE--LKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTMITYVGLSLSLLCLFLAALTFLLCRSIQNT-STSLHLQLSICLF
LAYLLFL-TGIKQTEP-------K---VLCK---VVAGVLHYLYLAAFTWMLLEGLHLFL
TVRNLRVANYTSA-GRFKKRFMYPVGYGVPAVIVAVSAAINPQGYGTT---KH-CWINL-
-E------KGFILSFLGP----ISAVIL--------------------------------
-----INLIFYLITLWIL-RDRLSSLNKDVSK-I--QNT--RMLTFKAIAQLFLLG--CS
WCL-GFFL-AELIKEPLRSILAYAFTITNVLQGVYIFLVHCLLNQQVIG--PILSSPQL-
PAGVL-SC-IYLA-------SP-SLPRDA-LLPDG-VFP--FSPSLPFSTE---------
-----------------------SKSSSPCL-----------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------MCTLNAKCVN
S-THCACLDGFQSRG-SRF-FTD-QS----------------------------------
------------------------T-----------------------------------
----------------------------------------------------------CD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECLGPN-PVNCGPDAKCIN-QPGSFNCSC-------ADGYESSSGK--ARFPNASEN
SC------------------------------------------------RVTLSS----
------------------------------------------------------------
------------------RC----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LQ
-------------------ILKLLQETTRS--FNSLLNRISLG---------------S-
SIGEGQVASAVTVLLQSVELV-ALA-AALRSPGQTTQNMSTES-------IVMETRVITG
NCSQHSEVFQ-LS------A-----------------DGE---------TMEV---HCTT
VTHAA-------TQG---HLGAA-ALIAYSSL-----HSTI-NARLPSS--------GCL
SAGRMLEK-----------------SHLGSRV-VSGAVGDG---GPIC-LSRP-ANFT--
-----L-RHQQ------------------P-RK-EQEV

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

AL-CVY--WKFE--AGKGSWSP
D-GCTTL-HVNS-THT-TCSCDH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAP---SA--VTES----RP---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LTILTYVGLSLSLLCLLLAILTFLLCRSLWNV-STALHLQLCLCLF
LADLLFL-SSQGVYSV-------S---VACA---VIAGLLHYLLLACFTWMFLEGLHLFL
TVRNLKVVNYTSA-SRFKKRHMYPFGYGFPALILAISAAVNPKGYGTS---EH-CWLSL-
-D------RGFRWSFLGP----VCAIIL--------------------------------
-----INVTFFALTLWIL-RSSLSSLNADVST-L--RGH--RLMTFKAIAQLFILG--CT
WCL-GLLH-VGP----AAMLMAYLFTVINSLQGAFIFLVHCLLNRQVRE--EYRRWIRGF
RPPGR-KSQTDDL-------S---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MQGPLL---LPALVFLLS-LFGA----VIQKTK---ASCPQCPENASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NTYCTCDRGYISGSGQKLF-------------------------------T--FPLEICK

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1069)

DINECQPPF-SVYCGVNAACQN-VEGSFYCHC-------VPGYKLHSGE--TQFKSSSEN
TCQDTTSSETTQGGKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IMDDL----------------------------EALLTNQ-TLLRTG------------
--------------------------------------------------ERQEISSR-A
TSILQDV--E------S----------------------------SV-------L-----
----------------ETAL-------KTP-EQKVQ----------RI------------
----------QNS-TVAVETRVITD-------NCS-------------------------
---EERQAFN-LN--VR-----------------------M-------NSMDI---HCRD
VIQGD-------TQG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
MD--EKDRLY-----------------LNSRV-VSAAIGPK---RNVS-LSTP-VTLT--
-----F-RHVK------------------I-NP-RSKKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEST--QQGGQWSR
D-GCFLI-SKNK-THT-MCNSTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---TS--QEED----PM---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSLSLLCLLLAALTFLLCKPIQNT-STSLHLQLSLCLF
LAHLLFL-VGIDQTES-------K---VLCA---IIAGALHYLYLAAFTWMLLESLHLFL
TAWNLTVANYSSI-NRLMKCVMFPVGYGVPTVIVAISAASRPHLYGTTD---R-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLVFFLLVFWIL-KRKLSSLNSEVST-I--QNT--RMLTFKATAQVIILG--CT
WCL-GFLQ-VGP----AARVMAYLFTIINTLQGFFIFLVYCVLSQQVQK--QYQKWFREM
VKSKP-ESETYTL-------SS-KVGPDS-KPSEGDV-----FP----------------
-----------GLVKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MRGSLLLPGLCFLLS-LSGA----VARKTT---GTCHPCPQNAYCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTYCTCSHGYKSESGQIYF-------------------------------T--FPLETCK

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECKPPI-NIYCGVNAKCQN-TEGSFYCHC-------ITGYRLLSGD--EKFSNSSEN
TCQKITPSNKTKDTKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQR-------
-VVERI----------------------------ESLLNNK-TLWGME------------
--------------------------------------------------ERRNIAST-A
TSFLQTV--E------S----------------------------TV-------L-----
----------------DTAL-------KAP-DQKIQ----------KV------------
----------QNS-TLAVETRVVTD-------C-S-------------------------
----QGIMFN-LK--AQ-----------------------M-------NSMDI---HCDD
IIQGD-------IQG-----PSAVAFVSFSSL-----GNI--INATF-FE---------E
MN--DKDRVY-----------------LNSQV-VSAAIGPK---RNTS-LSQS-VILN--
-----F-QHVK------------------M-KP-GIKKIF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WKGT--KEGGHWT-
E-GCVLM-QANE-THT-TCSSTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAF---HS--QKHD----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LNVITYVGLSLSLLCLLLAALTFLLCKPIQNT-STSLHLQLSICLF
LAHLIFL-TAIDQTEP-------K---VLCA---IIAGALHYLYLASFIWMLLEGLHLFL
TARNLMVVNYSSV-NKFMKKLMFPLGYGVPAVIVAISAAFKPHLYGTPD---R-CWLHT-
-D------QGFIWGFLGP----VCAVIC--------------------------------
-----VNFVFFFLVLWIL-KRKLSSLNSEVST-I--QNI--RMLTLKATAQLFILG--CT
WCL-GIFQ-LGP----AAHVMAYLFTIINSLQGFFIFLVYCLLSQQ------VQKWFGEI
IKSKS-ESETHTL-------SS-RFGPDS-KSSENKQR----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------LW----------------------------
----------------VPGLCILLN-LAAVTAQ-RSP-----NEVGSNCPQCPQHARCVN
N-TFCTCEPGFKPTNGKQI-FSD-LL-EVCEDINE-----------CA------------
------------------------------------------------------------
------------------------------------------------------------
------GPS-GVRCGPNADCKN-VDGNYSCSC-------VTGFTLPSGE--NQFKNLSEN
ECQVWVWVGTEPNPASLVMVNTALFPPNGPSTHSNIHIHACGPDSLFLPLA

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1173)

DMDECRHN-
SLLCKPHGVCTNVPGNY-TCTCQPGFGKSQKDTS----------KIC-TDID-ECH----
-----AK-RFPCH--NTASCTNTLGSFKCHCP----KGY--MPVPDSKDVTQN---TIC-
-------QGIAFVSWTL------------------PP-----------------------
------------------------------------------------------------
-----------------------------------------GVTSKSFS--H-FLNNTQN
HIQN---FIAGTAKEIFQGLLEEVDQLLGN--YGDLEALP--------------------
I---STRLKVATTLMTGMEGV-LHN-LFQAL---PSGQLH---------------VRTSK
GTELTLERQV-LE------N-----------------RAESIKLCHRDTQIML---NNDV
VWGKN-------HRG-----WAVAGLISNHGM-----KNLL-ANATLEVDSKKQVSLKKY
ETPKQRGQ-----------------LVLLSTV-SSFFVSNP---ETQM-LSSP-ITLT--
-----F-FHPD----------------V-P-IR-WKQE

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VI-CAF--WERD-NDGSDHWAT
R-GCEKT-GSSY-NST-TCSCTH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAQ---YD--IQED----PM---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTLITYMGLSLSLLCLFLAALTFLLCQGIQNT-STSLPLQLSVGLF
LADLLFL-SGIKRTEP-------E---PSLRWRFSTSVMFHHCWLATFTWMLLEGLHLFL
TLRNLKVANYTSA-SRFKKRFMYPFGYGIPAGIVAITAGVGYRGYGTS---TH-CWIN--
-T------RGYIWSFLGP----ILVIIL--------------------------------
-----INLLFYLTMLWIL-KDRLSSLNKDVST-I--QNT--RTLTFKALAQLFILG--CS
WGL-GFSL-MEPVGDVPKSVLAYAFTITNSLQGVYIFVVYCLLNYQVRE--QYKKW----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------G----SK-SVR-NRC--CRD--EDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTES-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLMVVSYSNV-SKFMKKFMFPVGYGVPAVIVAISAAFRPHLYGTPA---R-CWLQP-
-E------KGFIWGFLGP----VCAILF--------------------------------
-----VNLAFFLMTLCIL-KSKLSSLNSDVST-L--KNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAHAMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWLKQA
GKIQV-ESEQYTL-------SS-GLLSDA-RKHSVVR-----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------M-M---LTWD
TVHDP----GD--SG-----LAVVGLLSTPGM-----DRFL-AEAPLVLD----------
--AEEPTALR----ETHRGLLQETSRILLSDV-ISAFITNK---DTEN-LRSP-VTFV--
-----F-QH------------------SVT-PG-PGEK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VH-CVY--WEHG-QNGSGHWDT
R-GCWVA-STRD-NST-TCQCTH-LS----IF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAH--YSV--QEED----PT---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2028)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAFDRTEN-------K---VLCA---VIAGALHYLYLASFTWMLLVGLHLFL
SARNLTVVSYSSV-NRFMKKAMFPVGYGVPAVIVAISAASRPHLYGTPT---R-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWSFNLL--------------
LFWGYCGIFIWV--MFSL---ESMAV-----------

PF07645 // ENSGT00900000140800_1_Domain_1 (398, 434)

DVNECADTTTCPAYAKCTDTPDS
YYCT-CKRGFLSS

ENSGT00900000140800_1_Linker_1_3 (434, 450)

NGM--EQFKGPGVTCI

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 485)

DIDECSQSPPPCGPNSVCRNLLGRYKCSC--
WPGF

ENSGT00900000140800_1_Linker_3_5 (485, 506)

SSPTGNDWILG--NPGRFICT

PF07645 // ENSGT00900000140800_1_Domain_5 (506, 538)

DINECLSSGVCQEHAECINTSGSYKCRCQVGFIA-
------------------------------------------------------------
----------------------------------------------HNSICK

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 686)

DIDECSQS
PPPCGPNSVCENLLGRYKCNCLPGFSSPTG--NNWISGNPGRFVCTDINECLS-SGVCQE
HA------------------------ECI---NTLGSYKCR-------------------
--CQVG-------------FISHNS---------ICK-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECADPRTCPEHATCHNSPG
S-YSCVCNVGFE

ENSGT00900000140800_1_Linker_10_11 (853, 872)

SSGGKER-LLG--SGEICG

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECAR---NS-TICGLNSVCTNILGKY
NCSCLPGYFSPA--VWTPEKPEDFICT-DI--------DECSQD-PSPCGPNSVCINTLG
SYSCRCNK-GFRPNPGGSSNFTCQ------------------------------------
NVNECA--D-TTTCPAYAKCTD-TPDSYYCTC-------KRGFLPSNGV--KQFKGPG--
-----------------------------------------------VTCI

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1167)

DIDECSQS-
PPPCGPNSVCENILGRY-KCSCLPGFSSPTG-ND--WILGNPGRFIC-TDIN-ECLS-SG
V----------CQ--GHAECINTLGSYKCRCQ----VGF--IAHN-----------SIC-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1318)

DIDECSQDPSPCGPNS--------VCTNTL---GSYSCSCLEGFRPN--------AG--
-GSL------N-F-TCKR-I----------------------P-FK-C-------K-EDV
---IPDN--E-WV---QLCQVGA--A---VER--------EHGS---FC-----------
----------TLMNATFNVLDDACENRNTV--VSLK---STVESFASVLE---QTST-S-
NFTKEETSALATVVLESVKSTT-LA--AFLKPSA------NVSQTIQTEQLEIESKIIKE
ECNEENMTFH-FK------A-----------------KGD---------EMKI---GCST
IEESK-------STG-----TTGVAFVSFLGM-----ESFL-DESFFQDQ--------QM
PLAISQRK---------------VK--MNSRV-VQGIMTGE---KKDG-FSDP-IIYT--
-----L-ENI---E---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

PI-CVS--WDTN-VEGG-RWTS
S-GCVVL-EASE-THTV-CSCNQ-MV----NL-AII-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MA-Y--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGMIISLVCLVLAITTFILCRSIQNH-NTYLHLHLCVCLF
LAKALFL-TGVDKIHN----------KMGCA---IIAGFLHYLYLACFFWMLIEAVMLFL
MVRNLKVVNYFSS-RHIKMWYLCVFGYGIPGLVVAVSVGVQPQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTIIV--------------------------------
-----INSILLTWTLCIL-RQKLSSVNAEVSK-L--KDN--RLLTCKAFAQLFILG--CS
WVL-GIFQ-IGS----MARIMAYLFTIINSLQGAFIFIIHCLLNRQVQE--EYRRCLTRK
IKPSS-ESHTSGI-------LLSSVPSTSKTD----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECEPPS-TVSCGKFAQCWN-TDGSYYCTC-------SPGYQLVSGA--TMFRKESEN
TCQGCPPSQGN------------------------------------------------P
VPANNTSNLTLLLNH-S-------VSISH----T--KFFVKPENTTKDQDSEKCCVRPE-
------------------QDDKNTPTYTLGDL----DEQ--KRL---PSGPDSK-R--D-
HHKEPLPQGQTSPKEVKPG-----SMGGQTD---GGQKKKAKPHWQEAKGLA--------
-----ILC------------------------------PAGII-FPTWA-APSRVKSK--
-------------------------------------------------RFSRFFDR---
----------------VQYLSRNFN--SASVQSTVQE---VIQEVDEMLE---SPGDLG-
NLAPTEQHSVATNLLFGLE-NV-LRGLSKALHNGS-ATF---------------------
-TSSAGTEFS-LK--VME-E-----------------EDRNITLTQNQTKM-L---LTWD
TLHKS----SD--SG-----PIVVGLVSTPGM-----RKLL-ANVSLVLD----------
--TEEEIVLH----EMQMVLRQEISPILLSNV-VSAFINRN---NTQN-LNSP-VTFI--
-----F-QH------------------SVT-LG-PRQKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WENS-QNGSGHWAT
N-GCRMV-GTKD-NST-ICQCTH-LS----SF-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1879)

L-MAH--YEV--QEEN----TS---
--------------LNVI

PF00002 // ENSGT00900000140800_1_Domain_22 (1879, 1990)

TYIGLTLSLLF-------------IQNT-SISLHLQLSICLF
LAHLLFR-IAIDRTEI-------K---VLCS---IIAGALHYLYLASFTWMLLEGLHLFL
TACNLMVVNYSSV-NRFMKKLTFPV-----------------------------CWLHT-
-E------EGFIWTFLGS----INL-----------------------------------
---------VFLITFWIL-KNKLSLLNSDFFL-V--Y----------------VLGNTCI
TCNLGQLVSMHH----ASTYSPFLTLLIYSLEKMY-FITYHVLHTN--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------AAPCPPCPSDALCHN
S-THCVCMEGFRSRSGRKY-FTE-TK-DQCEALSQP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------LNYWRIFKWN-KIGSYICSC-------LGL--HII-------------
-----SWV------AKY---------------------------------LEFNY-----
---------------------------PECYVWL----------ARL-IQ-L--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------I---------------Y-
PCSWSLKFQWITQLLHDVEMT-VWN-QSSAS---L-GKGSNSAFN-----IVYEAKKCHE
-------QTF-LE------A-----------------GNN---------SMNI---NCAD
AFKGA-------RKE-----VSTVALITYQSV-----GDIL-DASFFND--------PRG
-----RRA-----------------VRLNSCV-VSGTVGLR---DKLS-LAAP-VSLT--
-----F-QHTQ------------------T-GA-ENRQYF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEGS--EEGGSWST
D-GCHPL-GGND-SYT-LCECHH-LS----TF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL----R--PKDD----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LSVVTQVGLSLSVLCLLLAALTFLLCRPIRNT-STTLHLHLAVCLL
LAHLLFL-SGIQRTEP-------K---TLCS---IIAGLLHFLYLATFSWSLLEGLHLFL
TVRNLRVANYTSA-HRLKKRFMYPLGYGLPAAVVTVCAAAGHQHYGTS---TH-CWLTV-
-D------RGFIWSFLGP----VAAIIL--------------------------------
-----INFVFYFQILWVL-RSKLSSLNKEVST-I--QDT--RVMTFKAIAQFFVLA--VL
GAL-VILP-GGRRRETVESVVAYFFTIVNVLQGVLLFVVHCLLNRPVRP--AVPLSPPSQ
---------------------------SS-LGRPL-----AFWPLLGLLYS---------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------A---C---PRRCPANSKCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTACHCDSGFKSPSGES-K-------------------------------V--NQWETCE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECEQRG-VKACGRDAECHN-TVGSYYCTC-------IQGYRLVSGA--AKFSNASEN
TCQEIKKAQSS-------------------------------------------------
PKEVNPGAMGTQTMGLQ-----KTELSPS----R--QGP-----QVC-VPDVNECTSGQN
P----------CH--KTTHCLNNVGSYKCRCR----HGW--KPIPGSPNGQINT-I--C-
EEGSECTCHVHTDHHDN--------VSMHSQ---GDVGRHVRGHYKEPSGKLRECVSLLN
GAD---------------------------------------------I-NPAHLRRR--
-------------------------------------------------SSALFSKR---
----------------GHGPSRCWP--GPL-SPCCQQ---LAGAFLHLAP---PPGDQC-
TSYQA-----SASQTATLY-QI-QKGLTEVGPNGH-FYY-------------------R-
-ERVNSNKLS-LE--VKK-Q-----------------GDKNVTLSVNQAKM-L---VNWD
VVQDS----GD--SG-----PAAVGLFSSPGM-----GKLL-VEAPLVLE----------
--TEEQSVLN----ETRKGLQQEVSPVLLSDV-ISVFVSNK---DTQN-LSSP-VTFV--
-----F-KKAHHKQ----D-------LSLT-PG-PM

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEPG-QNGSGHWST
K-GCWIV-GTRD-IST-TCQCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------K---VLCA---MIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSV-SRFMKKFMLPVGYGVPALIVAISAVSRPHLYGTPA---R-CWLHP-
-E------KGFIWGFLGP----VCAILF--------------------------------
-----VNLAFFLMTLWIL-KSKLSSLNSDVST-L--KNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAHAMAYLFTIINSLQGVFIFLVYCLLSQQVRK--QYRKW----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------S-SCQ-----GPTGVECGPNAHCTNEPG
S-FYCTCNDGFKSSSGKARFTQM-GE-NSCS

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 910)

DIDECRG---PSGVNCGPNAHCTNEPGSF
HCACNNGFTSSSGKATFT-HMSENSCQ-DI--------DECRGPSGVICGPNAHCTNVPG
SFYCTCNDGFKSSSE------------------------------------------KIA
DIDECQGPT-GVNCGPNATCTN-EPGSFYCAC-------NNGFTSSSGN--ATFVHM---
---------------------------------------------SENSCQDINECREPS
GVNCGPNAHCINEPGSF-HCACNDGFKSSSGKATFT---HMRE-NSC-S

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1243)

DID-ECQ----
-----GPTGVNCG--PNATCTNKPGSFHCACN----DGF--N

ENSGT00900000140800_1_Linker_15_17 (1243, 1262)

SSSGKATFTHMS-ENSC-
Q

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1306)

DVDECAENPAICGLSL--------YCTNTP---GNYTCQCPPGYTLPPAALSTAGTVPC
P-----------L-LCLRCS-A-----------------GRM----------------LS
SSVLRDV--W------MCCQA-----------------LEGNQESNPFC--T--------
-----------LMEGIKETQSSAFGNGSNP--VSLQK---ATASFDSFVG---NIRELS-
SGHKEEASLVATVFLKSVESV-AFE-AALRSPSNQ-------SEPIKTKMMTIAAKAVKD
NCSSQGESIS-LN------A-----------------KNE---------SMAI---YCTT
VVGSD-------SSG-----TGAVVFIVYDQL-----ESLL-KDCVSDQ---------SL
TGADRLGD-----------------VTLNSNV-VSATIGKS---RNLS---RP-FNFT--
-----L-EHKE----------------GQS-QA-ETPVP---ES--QTNS--LRSGELYP
T-GCPII-KNLK-THSYSCSLNV-VG----TK-ELV-IAR---AD--LALS----DS---
--------------MDLLSTAGRVASIDCTYSALGPFFLNKIAPKK-CEIFNKPLC--HV
GPHTTYS-FPPSPIKSGG-----Q--

PF00002 // ENSGT00900000140800_1_Domain_22 (1947, 2196)

-VACP---VIAGFLHYLFLACFTWMFLEGLHLFL
TVRNLKMVNYTSS-SRNKKRYMYLFGYGFPALIVAISAAANSEGYGTS---EH-CWLNT-
-G------KGFLWSFLGP----VCLIIM--------------------------------
-----TNCTFFITTLWIL-RDKICSLNSDVST-L--KNT--RLLTFKAIAQLFILG--CT
WSF-GFLQ-VGQ----AATFMAYLFTIVNSLQGAFIFLVHCLLNRQVRE--EYKRWIQRI
EKPST-RTTTLEI-------SM-SAAPLS-TGIVV-LFSFSNTAM---------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---KEEASATATAFLKSVESAT-MA--AFNTPSV------NTSQIVRSEYLDIESKVIEK
GCSMEKEVFR-LK------A-----------------KGD---------MLQI---DCDA
VSGET-------SQG-----KSLPPIIPGEHL-----GKWFRKNRYLECG--------NI
SASYG----------------------PN----------SW---HSST-FKSP-SLSSIS
NHSI-S-SCL---Q---------------P-KI-YSDQ

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

LI-CVS--WVSD-GHDG-WWTS
A-GCKME-NSNV-THSV-CSCRH-LA----NL-AII-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MA-S--GE--ITMD----LA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LFVISHVGLILSLLCLCLAIITFLQCRSIQNP-NTSIHLHLCVCLF
LAELLFL-TGVDKTDN----------KTLCA---VIAGLLHYLFLACFTWMLVEAVMLFL
TVRNLKVVNYFSS-RNIKVQHLCVFGYGFPGVIVAAAAGIQSRDYGMHN---R-CWLNT-
-E------SGFIWSFLGP----VCCIIV--------------------------------
-----INLILFTLTLWIL-REKLATVNANVST-L--RNT--RVLTLKASAQLFILG--CT
WIL-GIFQ-LGP----AAKVMAYLFTIINSLQGVFIFFIHCVLNRQVRD--EYRRCITGI
SKRST-KTHTSGV-------MLSTITSSSKT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MRI----------FPPLSISALRVL----------------------
----------------------------MVWSV-VQL-----QNVSASCPQCSENADCYN
S-THCICKDGFWTGPDSRI-IIE-PH-VKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1065)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QLG-IPVCKDVSYCKN-KIGTYICSC-------VVNY-RIF-------------
-----NWV------AGI---------------------------------VDIEN-----
---------------------------PECYD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------ETAVALIAYQSL-----GKYL-NGSFFN---------KEG
-----IQE-----------------VKLNSLI-VSGAIHSE---VKPV-LSEP-VLLT--
-----L-QNTQ------------------P-ID-PRAEHI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVH--WEGS--EEGGSWST
K-GCSHM-HTND-SYT-TCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---S---LEED-SVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2032)

-LSVITYVGLSLSLLCLFLAAVTFLLCRPIQNI-STTLHLQLSICLF
LADLLFL-TGINRTEP-------K---ILCS---LIAGMLHYLYLASFMWMFLEGLHLFL
TVRNLKVANYSSS-GRFKKRFMYPVGYGIPAFIVTVSAITGHENYGTH---T--------
------------------------------------------------------------
-----------------------------------------QVMTFKAIVQLFVLG--CS
WGI-GLFM-VFEFGKTVRLIIAYLFTIINVLQGVLIFVVHCLLNRQVRM--EYKKWFHKM
QKSAE-IE-STEM-------SY-STTHTK-MVSST-PKS-RYGLI---------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--GHIRPTRKPN------------TKG

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NNCRDSTLCPAYATCTNTVDS
YYCA-CKQGFLSSNGQ--NHFKDPGVRCKDIDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQPCGPNSSCKNLSGRYKCSCLDGFSSPTG--NDWVPGKPGNFSCTDINECLT-SSVCPE
HS------------------------DCV---NSMGSYSCS-------------------
--CQVG-------------FISRNS---------TCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECADPRACPEHATCNNTVG
N-YSCFCNPGFESSSGHLS-FQG--LKASC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECT-----EMCPINSTCTN-TPG

PF12662 // ENSGT00900000140800_1_Domain_14 (1047, 1265)

SYFCTC-------HPGFAPSNGQ--LNFTDQG--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFHPN--------PE--
-GSQK--DG-N-F-SCQR-V----------------------L-FK-C-------K-EDV
---IPDN--K-QI---QQCQEGT--A---VKP--------AYVS---FC-----------
----------AQINNIFSVLDKVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESMT-LA--SFWKPSA------NITPAVRTEYLDIESKVINK
ECSEENVTLD-LV------A-----------------KGD---------KMKI---GCST
IEESE-------STE-----TTGVAFVSFVGM-----ESVL-NERFFKDH--------QA
PLTTSEIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-IIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-TYTI-CSCNQ-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGIIISLVCLVLAIATFLLCRSIRNH-NTYLHLHLCVCLL
LAKTLFL-AGIHKTDN----------KMGCA---IIAGFLHYLFLACFFWMLVEAVILFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIV--------------------------------
-----INSLLLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNGQVRE--EYKRWITGK
TKPSS-QSQTSRI-------LLSSMPSASKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MGGRVFLAFCVWLT-LLGA----ETQD---FRDCARWCPENSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATACRCNPGFSASSE--IF-------------------------------T--FPTEICD
DINECAPPS-EVSCGKFSDCRN-IEGSYDCVC-------NPGYELVSGA--KTFKNESEN
TCQ

PF07645 // ENSGT00900000140800_1_Domain_14 (1084, 1178)

DVDE-CQR------------------------------------------------N
PRLCKSYGTCVNTAGSY-TCQCLPGFKFK----P--EDP-----KLC-TDVN-ECTSGQN
L----------CH--SSTHCLNNVGSYQCRCR----PGW--QPIPGSPNGPNNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DVDECSSGLHQCDSST--------VCFNTV---GSYTCRCRPGWEPKHGIPNNLKDTV-
--------------------------------------CEEMN-FLTWT-PPPGVHSQ--
-------------------------------------------------TLSQFFNK---
----------------VQDLGRDFK--TSSAKVTIQS---ILKGLDELLE---APGDLE-
TLPRFQQHCVATHLLDGLE-NV-LRGLSKNLPIGL-LNF---------------------
-SYPAGTEFS-LE--VQK-Q-----------------VDRNVTLRQNQATM-Q---LDWN
LAQKS----GD--PG-----PSVVGLVSVPGM-----GKLL-AEAPLVSE----------
--PEKQVVLN----ETHQGLL----PILLSDV-ISAFLSNN---DTQN-LSSP-VTFT--
-----F-SHRV-SAGGVVGESQSFPSRLWL-VI-PRRKVF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVF--WEHG-QNGCGHWAT
T-GCSTM-GTRD-TST-ICRCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAP--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLL
VAHLLFL-VGIDRTEH-------E---VLCA---IIAGALHYLYLAAFTWMLLEALYLFL
TARNLMVVNYSSI-NRFTKKLMFPVGYGVPAVIVAISAASRPHLYGTPS---RLCWLDY-
-T------AGYIWLFTFESWGILYGYIQ--------------------------------
-----VNLALLLVTLWIL-KNRLSSLNNEVST-L--QNT--RMLAFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWS---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------IPALVFLLS-LFGA----VIQKTK---ASCPQCPENASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NTYCTCDPGYTSGSGQKLF-------------------------------T--FPLEICK

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1075)

DINECQPPF-SVYCGVNAACQN-VEGSFYCHC-------VPGYKLRSGD--AQFKGSSEN
TCQDATSSETTQGGKQ--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDNF----------------------------ELLLTNQ-TLLRTG------------
--------------------------------------------------ERQEISSR-A
TSILQDV--E------S----------------------------SV-------L-----
----------------ETAL-------RTP-EQKVQ----------KI------------
----------QNS-TVAVETRVITD-------NCS-------------------------
---EERQTFN-LN--VQ-----------------------M-------NSMDI---RCRD
IIQGD-------PQG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
MN--GKDRLY-----------------LNSQV-VSAAIGPK---RNVS-LSTP-VMLT--
-----F-QHVK------------------I-NP-RSKKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEST--EQGGQWSR
D-GCFLI-SMNK-SHT-TCNSTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---TS--QEED----PM---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-MGIDQTEP-------K---VLCA---IIAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVANYSSI-NRLMKWVMFPVGYGCPAVIVAISAA---------S---R-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLIFFLLVFWIL-KRKLSSLNSEVST-I--QNT--RMLTFKATAQLFILG--CT
WCL-GFLQ-VGP----AARVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREM
IKSKS-ESETYTL-------SS-KVGPDS-KPSEVRQ-----------------------
-------------VKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------V-------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------

PF07645 // ENSGT00900000140800_1_Domain_6 (654, 685)

-DECSQS
PNPCGPNTRCTNVIGRYKCRCLPG

ENSGT00900000140800_1_Linker_6_9 (685, 707)

FASPRG--NSWIPGRTGPFQCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 816)

DIDECLS-KAACPL
HY------------------------TCQ---NTPGSYKCT-------------------
--CSAG-------------FTLRNS---------QCE-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
DVDECM--D-ATACPTHAICTN-TPGNYFCTC-------KHGYKPSTSE--VNFRGQG--
-----------------------------------------------IQCR---------
------------------------------------------------------------
------------------------------------------------------------
-XXXXXXXXXXXXXXXX--------XXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX---------------------XXXXXXX------XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------
----------XXXXXXXXXXXXXXXXXXXX--XXXX---KAAEDLASVLE---ETSTWH-
NLSQEGTSTLATAFLESVESAT-LA--AFASLSG------NTSQTVENEYLEIKSKVIQD
ECLMENLVLT-LS------A-----------------KGD---------SMQI---ECNT
INESV-------SLX-----XXXXXXXXXXXX-----XXXX-XXXXXXXX--------XX
XXXXXXXX---------------XX--XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX--
-----XXXXX---X---------------XXXXXXXXXXXXXXX--XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX--XXXXXXXX----XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00002 // ENSGT00900000140800_1_Domain_22 (1890, 2207)

XXXXXXXXIMCMIIAGL--LHYLFLACFAWM
LVEAVMLFLTVRNLEVV-------------------------------------------
--------NYFSS-RNIKMCYLCSFGYGLPGLIVVG--SRKPKGYGMKD---R-CWLNT-
-D------TGFIWSFLGP----VCTIIM--------------------------------
-----INSVLLMWTLWIL-RNKLSSVNAEVST-I--KDK--RLLTFKAFAQLFILG--SS
WIL-GIFQ-IGP----IANVMAYLFTIINSLQGTFIFIIHCVLNRQVRK--EYARCFSGV
SKVSP-TSQTSGI-------LLSATSQS--------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MRIKCLS---LLLALS---------------------
--------------------------ILLAVSG-SEA-----QNSGAPCPLCPANAVCYN
H-THCVCMHGFQSHSGRDY-FIG-TK-DKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1060)

DINE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KTG-RAKCKKVSYCKN-KIGSYICSC-------LISS--WL-------------
-----YWI------AGI---------------------------------AEIDR-----
---------------------------PECYENH----------IQK-TP-S-QE-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------NVWELSTQ-------------------
NISKKEIAKRVTRLLHHVEMT-IWN-QSFDS---P-GKGNNPSLN-----IVYETKKCHE
-------KTF-LE------A-----------------GNN---------TMNI---NCAG
AFKGA-------RKD-----VSTVALITYESL-----GNIL-NGSFFNN--------SRG
-----MQG-----------------VKLNSHV-VSGTVGLQ---DKVY-LSEP-VLLT--
-----F-QHTQ------------------P-GI-ENVQHF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEGS--EEGGSWST
E-GCLRM-GRND-SYT-TCKCYH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL----S--PKEG----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITYVGLSLSLLCLFLAAVTFLLCRPIQNT-GTTLHLHLALCLF
LAHFLFL-TGIRRTEP-------K---VLCS---VIAGVLHFLYLAAFIWMLLEGLHLFL
TVRNLQVANYTSA-RRFKKRFMYPLGYGIPAVIVTVCAIVGHKNYGTS---TH-CWLTA-
-D------KGFIWSFMGP----VAVIIT--------------------------------
-----INLGFYFRVLWIL-RSKLSSLNKEVST-I--QDT--RLMTFKAISQLFVLG--CS
WGL-AFFM-AEGVGETVGSAITYLFTIINVLQGVLLFVVYCLLNHQVRM--EYKKWFSRM
WKGTE-TD-SADM-------SH-STTHTK-MEEPR-KPS-EYAL----------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHIWE--MHTGPTLKPTI-----------KNA

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NKCREATMCPAYATCTSNMDS
YYCT-CKRGFLSS

ENSGT00900000140800_1_Linker_1_4 (434, 450)

NGQ--RHFKGPGVECK

PF07645 // ENSGT00900000140800_1_Domain_4 (450, 686)

DIDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQPCGPNSVCKNLSGRYNCSCLHGFSSPTG--NGWISGKPGNFSCTDINECLT-NGICPE
HS------------------------DCV---NLMGSYLCS-------------------
--CQVG-------------FISRNS---------SCE-ENYLGVVACACGGRIARHQEVE
AAVHCAY-----------V-DEC--SRNSN------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
YIDECI-----EMCPINSTCTN-TPGSYFCNC-------HPGFAPSNGQ--LNFTDQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1323)

DIDECLQDPSTCGPNS--------VCTNAL---GSYNCSCIAGFHPN--------PE--
-GSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDI
---IPNN--E-QV---QQCQEGT--T---VQP--------EYDS---FC-----------
----------ALINDMFDILDNACENKTAV--VSMK---SMAESFVPVLE---RMSSWT-
NFTEKEISSLATVFLESVESTT-LA--AFLRPSE------NATQTVQTEYLDIESKVIDK
ECSEENVTLS-LG------A-----------------KRD---------KMKI---GCST
IEESE-------SRG-----TTGVAFVSFVGM-----ESVL-DERFFHNP--------QT
PLANSEEK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WRTD-VEGG-RWTP
S-GCVVL-EASE-VHTI-CSCNH-LA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYVISHVGIIISLVCLILAIATFLLCRSMRNH-NTYLHLHLCVCLL
LAKTLFL-AGIDKTDN----------QMGCA---IIAGFLHYLFLACFFWMLVEAVMIFL
MVRNLKVVNYSSS-RNIKMPCLCVFGYGLPGLVVVISASVQPQGYGMYN---R-CSGHC-
-P--------FVY-----------------------------------------------
----PINSILLTWTLWIL-RQRLSTVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-FGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYKRWITGK
TKPSS-ESQTSRI-------LLSSMPSTSKTVRDC-MLP--VGTGQGRCQPPTDTQLCHV
LGTEW--ELRVLTLGSSRV-KYAVKD--QGIICIY-------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------IYLQNIT---NSASQIL---SDSSWS-
NLSSSAFSAMVNGLLETVELS-VLE-SFSKTPTN--RNFSSPEIE--TDYRDVATKVAEE
NC-----SFLTIT------V-----------------GLN---------SMQV---SCDL
LPKPE-------GQA------NGAVFISYKNL-----GSRL-SGSFLKLS--------E-
-DPEDNNP-----------------AVVNSQV-VTGGITSQ---TREN-LNPP-VSFY--
-----L-NNLQ------------------A-PD-SF

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

HISL-CVY--WDPK----LSGWSQ
R-GCNII-FSNV-SHT-VCSCDH-LS----TF-AVI-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

IAP---CD--IKED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-RG---
--------------LHQVSRIGLGISVLCLFLSLVTFLLCRSLRSA-HTSMLIALCGCLF
LGQLIIL-FGLPQTGV-------K---ILCS---IIAGCLHYILLCAFCWMTLESVLLFL
TVRNLNAMNYLTS-RRSHFPTACIIGFGVPAVIVAISAGVRSDGYGTG---KS-CWLSL-
---------NLIWSFLGP----VCVFIT--------------------------------
-----INTTLLILTFWLL-RVKLASLNTNVSS-L--KNT--RLLAFKALVQLFILG--ST
WIL-GFFQ-CGP----GAIVASYLFTICNSLQGAFIFLVHCLLNHQVRE--EYRKVFHRL
HVQKP-ES--EGV-------SG-STVPMT-LKSVS-LTL---------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MVNVQGLCFLLS-LSGS----IVQEAK---AACPPCPPNAYCS----
------------------------------------------------------------
-----------------------------------------------------------R
DTYCTCNAGYASGSGQKLF-------------------------------T--SPSETCK

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECKPPF-SIYCGVNAECQN-VEGSFYCHC-------VPGYKLLSGA--AQFQNSNEN
TCQNVTTLKTTQGKKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LEQ-------
-IVDKF----------------------------ESLLTNK-TLWTTG------------
--------------------------------------------------KTQEVASM-V
TFGLRKV--E------V----------------------------SA-------I-----
----------------KTAL-------EDP-EQEVQ----------KI------------
----------QTS-TMAIETRVVTD-------NCS-------------------------
---EERKIFN-LG--AQ-----------------------M-------NSMNI---HCND
IVQGN-------TQG-----PSAVTFISYSSL-----EDI--INARF-FE---------E
MD--KKDKVY-----------------LNSKV-VSAAIGPK---KNIS-FSKS-VMLT--
-----F-QNVK------------------M-NH-HNKKAF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKST--EQGGHWSR
D-GCSLV-QVNR-SHT-ICSSSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAF---TN--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------E---VLCT---TIASALHFLYLASFTWMLLEGLHLFL
AAQNLTMVNYSSR-NRLMKKFMFPVGYGVPAVIVAISAASKPHLYGTPD---R-CWLDL-
-D------QGFIWGFLGP----VCVICC--------------------------------
-----MNLVFFLLALWIL-KRKLYSLNSEVST-I--QHT--RMLTLKAIAQLFILG--CT
WCL-GLLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVRK--QYQNWIRGI
MRSKS-VSGIYTL-------SS-NLNIFY-E----GMF----FP----------------
-----------GQVKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------METL-VLE-DAFKSENKI--QAEDDY------VVVDRRVVPNN
SCSERKELFT-LK------A-----------------GED---------IMDI---HCSD
VIRGN-------TTG-----QSVVAFLSYPFL-----GFII-NGSFFEE---------RH
--SRKYVN-----------------ISLNSRI-VSGTTGLR---QNSN-LASS-VILT--
-----F-HHLQ----------------E-N-FS-QDLQ

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

FL-CVY--WDSS--KEGGSWSR
K-GCSLV-KTND-THT-SCSCSH-LS----SF-ALL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAL---TG--QEED----DV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITYVGLSISLLCLFLAVLTFLLCRTIQNI-STSLHLQLSLCLF
LADLLFL-IGIEQTSN-------K---VLCS---IIAGGLHYLYLASFTWMFLEGLHLFL
TVRNLKVANYTSA-SRFKKGFMYPFGYGIPAVIVAVSVGINPHGYGAE---NH-CWLAL-
-H------KSFIWSFVGP----VIAIIL--------------------------------
-----LNLAFYSMTLWIL-RDKLSSLNKEVST-I--QNT--RTLTFKAFAQFFILG--CS
WSL-SFFL-TESITEPAQSVLAYAFTIINSLQGTYIFLVHCVLNRQVQE--EYRKCFKGI
QKRTE-TDTIDML-------SA-PTLHSK-VIEEL-EKSMDFSKRKQSS-----------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------LG-
-G-----NP-YLPSFCVLGLCVLLI-PLGA----IAHK---NGAPCARCPRNAHCT----
------------------------------------------------------------
-----------------------------------------------------------N
ASSCRCDPGFTSLSGKVIF-------------------------------S--TSSEVCT

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECGPPL-YMSCGSLAHCHN-VEGSYYCEC-------APGHELLSGG--TKFQSEKEN
TCQGKTFQSII-------------------------------------------------
----------NFHTGHFVFTQ----------------LF-----DPC-LKVS-EMTKRQG
MFSIHKEKSKLNS--TLNLIFNDSNHFILKCDSNQREGQIPT-SLGWKRFPGSW-V--N-
HY

PF07645 // ENSGT00900000140800_1_Domain_17 (1263, 1306)

VDECSSGKHQCHNTT--------HCINVK---GSYKCYCHHDWVAR----SRPLHGLN
F----------------------------TILVLLPLFPADVH-FPSWT-SPSGVNSQ--
-------------------------------------------------SLSRFFDK---
----------------VQQLSQDFK--PALAKNTIQD---LMQEVDELLE---TPGDLE-
TLAPSEQHCVATHLLVGLE-DV-LRVLSKLLPNGP-LTA---------------------
-HAPAGTGLS-LT--VQD-Q-----------------GIGDVTLGQSQAKM-Q---LKWD
VARES----ND--LG-----PSVVGLVSTPGM-----SKLL-AEAPLVLD----------
--SKQQTVLR----E-HRDFLAGGSPVLLSDV-VSAFVSNK---DTQN-LGSP-VTFI--
-----F-SHHS-VT-----------------PG-PTQKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WEHS-QDGCGHWST
T-GCRMA-ATGD-AST-TCQCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--GHI--QQED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LAVITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDQTKI-------K---LLCA---IIAGALHYLYLASFTWMLLDGLHLFL
TARNLMVVNYSSM-SRFTKRLMFPVGYGVPALIVAVSAASRPSLYGTPT---R-CWLHT-
-E------KGFVWTFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIV-RNKLSSLNRDVST-L--QNT--RMLTFKATAQLLILG--CT
WCL-GLLQ-VGP----AARVMAYLFTIINSLQGMFIFLVYCLLSQQVRE--QYGKWFRGV
RKAKA-EPENYTL-------SS-RTVSDA--SKHSAVRLCSV-P----------------
-----------RALP---------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------GIF-FPTWT-QPHGIKSQ--
-------------------------------------------------RLSHFFER---
----------------VQDLSRKFI--PDSVQDTIQD---LIQGVDELLE---TPEDLE-
DLPPSEQHCVATNLLVGLE-DV-LRNISQALPNGT-LTF---------------------
-NAPAGTDLS-LA--VQE-Q-----------------GHTNVTLSSNQAKM-L---LNWD
VVHET----GD--SG-----PSVVGLVSTPGM-----GKLL-TEAPLVLE----------
--SEKQAVLH----GKQKGVLQGVPSVLLSDV-ISAFMSNR---DTQN-LSSP-VTFI--
-----F-H-HS-AT-----------------LG-PK

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEHS-QDGYGHWST
T-GCRMV-ATRD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PL---
--------------LAAITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSA-SRVMKKLMFPVGYGAPAIIVAISAPPEHDRQRKAL---R-CWLHT-
-D------KGFIWTFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIV-KNKLSSLDRDVST-L--QNT--RMLTFKATAQLLILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIVNSLQGVFLFLVYCLLSQQVRE--QYKKWFKGV
RKTKA-ESEKYTL-------SS-GTMSDA--SKHSEVRLCSV-P----------------
-----------R------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------CDC---------DV-LLL-PFA---GS--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-TL---
--------------LAVITYVGLSLSLLCLLLG--PFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSA-SRVMKKLMFPVGYGAPAIIVAISAASRPHLYGTLT---R-CWLYP-
-S------ERFLWSFLGP----VCVIFS--------------------------------
-----VNLAFVLMTLWIL-KSKLSSLNSDVST-L--QNT--RMLTFKATAQLLILG--CT
WCL-GVLQ-VGP----AAHVMAYLFTIVNSLQGVFLFLVYCLLSQQV-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------PGFLVLL-----L-LSLG---LAAQNLRGC---APWCPRNSVCV----
------------------------------------------------------------
-----------------------------------------------------------S
ATACRCHPGFSSWSGEI-I-------------------------------T--SPADSCA
DINECGPP-LAVSCGKFADCQN-VDGSHYCTC-------SPGYGLVSGA--TTFRNESEN
TCQDVDECQQ-------------------------------------------------K
PRICKGRSVCINTLGSY-TCTCPPGLELN----P--KDP-----NLC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1249)

DVN-ECASGHN
P----------CH--SSTHCLNIVGGYKCHCY----PGW--KPVPGSP

ENSGT00900000140800_1_Linker_15_17 (1249, 1266)

EGPDST-I--C-
ADVDE

PF00008 // ENSGT00900000140800_1_Domain_17 (1266, 1306)

CSSGRHPCHSST--------ICVNTV---GSYRCHCHPGWTPLPGLRDNQNTTVC
EE---------------------------------------VS-FPIWT-PPPGIQSQ--
-------------------------------------------------HLSHFFER---
----------------IRDLRRRFQ--SASAQDTFKG---LIHAVDHLLE---TPGDLE-
TLPRSEQHCVAANLLFGLE-DV-LRGLSQALSNGS-LTF----NS---------------
PA--GTGNLT-LE--VLE-Q-----------------GDRSISLSQNRAKM-L---LNWE
TVQGS----AD--SG-----PSVVGLVSTPGM-----GKLL-AEAPLVLD----------
--PERQEVVW----ETHKDLLQEVTHVLLSDV-ITAFLSNR---DTQN-LSSP-VTFI--
-----F-NHVS----------------PVT-PR-PRKK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VL-CVF--WEHS-GNGSGHWAT
T-GCTMV-GTRD-TST-TCRCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MVH--YNL--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LDVITHVGLSLSLLCLLLAALTFLLCRAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEI-------Q---MLCA---VIAGALHYLYLASFTWMLLEGLHLFL
TARKLTVVNYSSV-SRFMKKLMFPVGYGVPAVIVAVSAASRPRLYGTST---R-CWLNT-
-D------KGFIWAFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIV-KNKLSSLNSDVST-L--KNT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVHCLLSQQVQQ--QYRKWFKGV
TKTKA-ESEKYTL-------SS-RAVSDA--SKHSVVR----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------CPQNAICVN-K---THCAC-------ENGFVTTSGE--KYFSDF---
----------------------------------------------LEICDDLNECLPPI
KIHCGKNASCINTYGGY-YCGCNTGYSLPSGETKFPN-----P-MDC-Q

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1245)

DIN-EC-----
-----ET-IFVCG--QNANCVNTDGSFHCICT----TGY--ALPSGENKFSDAV-MNNC-
QAPALASPPAKDLRF-----------------------FCRTHSLA--------------
------------------------------------------------------------
-------------------------------------QV--------FG--FSFNPQDAD
KSENDIVWPRYTKHKN--TLGSPYQ-------KVSEKNIT---GKNFSLE---HGAR---
-----------HYFLAPALVKARFHFISLNYPD---EKMLTQ-KSFKKSVMTSPSP----
--SKKLTNWM-LR------C-----------------LNN---------TSSP---NVFL
VSILD-------QQN-----INKL--RSVVSL-----KA---KDSNQIT--------PNF
SLEKPGAR-----------------VTIDSSV-VTVFLETT---QNAN-LSTP-VIFT--
-----F-QHNH------------------M-KN-MKE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KSL-CVY--WD------DTVWSN
K-GCKTI-SFND-SHT-VCSCSH-FS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAS---VE--LKED----FV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLGLSLLCLFLAALTFLLCRAIRGT-GTLLHLQLSLCLF
LANLLFL-TGIERTEP-------K---IMCS---IIAGGLHYLYLAAFTWMFLEGLHLFL
TVRNLRVANYTSA-SRFKKRFMYPFGYGIPAVIVAVSAGIVPQGYGTN---HY-CWLNL-
-H------RGFVWSFMGP----VFIIIL--------------------------------
-----INLSFYFTTLWIL-RDRLSSLNKEVST-I--QNT--RTLTIKALAQLFILG--CS
WSL-GFFL-IDSIAESIRLIIAYAFTIINSLQGVYIFLVHCVLNRQVQE--EYKKCFKRS
KERTE-TD-TYVL-------SS-STSHTR-TRALS-KHEIHL------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHTGPTLKPT------------TKDNKCRDSTMCPSHATCTSTVD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCA-CKQGFRSSNGQ--NHFKDPGVECKDVDECSE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SQPCGPNSVCKNLSGRYECSCLHGFSSPTG--NNWKPGKPGNFSCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 855)

DIDECT--------
------------------------------------------------------------
----------------------------------------------EMCLINSTCTNTPG
S-YFCTCHPGFAPSNGQLN-FTD--QK--VECR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1324)

DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPD--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQDRT--T---VKP--------EYVS---FC-----------
----------AQMNNIFSVLDNVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVETLT-LA--AFLKPSA------NVTQTVRTDYLDIESKVINK
ECSEENVN-----------LSLAAK-------------GD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYVISHVGMIISLVCLVLAIATFLLCQSIRNH-ITYLHLHLCVCLL
LAQILFL-AGIDKTDN----------QTGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIA--------------------------------
-----INSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYKRWITGK
MKPSS-QSQTSSI-------LLSSMPSTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------K----HD-CGP-LSA---AS--QEED----PT---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2028)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TATDRTES-------K---VLCA---VIAGALHYLYLASFTWMLLVGLHLFL
SARNLTVVNYSGI-NRFMKKAMFPVGYGVPAVIVAISAASRPHLYGTPT---R-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------MVCQ

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 686)

DVDECSQI
PNPCGLNTNCINVIGSYKCSCLPGF

ENSGT00900000140800_1_Linker_6_9 (686, 707)

SSPSG--NSWLRGATGSFQCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 815)

DIDECLN-ATACLQ
NS------------------------ACW---NTPGSYNCI-------------------
--CNGG-------------FTFRNS---------

ENSGT00900000140800_1_Linker_9_10 (815, 819)

QCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 855)

DVDECLDPTACPEHATCTNGLG
N-YFCTCNRGYKSNNGEMT-FRG--QETQCNNLEHLVPEELHS-R---------------
--------------TWLGTKRK--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------RASPPFWVH--YFR---------------------
--------------------------------------------------------KGV-
DKIGTVDRKPTSEGLQS--------VLPNEM---DLSELLCFILQSSS--------PK--
-GEAI--EG-S-E-KVMR-A----------------------P-IM-C-------K-ADL
---VD-Q--E-QM---KYCQSNSTHP---VLP--------KYI---PFC-----------
----------MLMNSTFNVLEDTCENKTIT--VSLQ---KAAGNFASVLK---ETSTWH-
KLSQKETSTVATVFLDSVESAT-LA--ALASPSG------KMNETVTTEYLEIRSKVIQE
DILVENVALT-FS------V-----------------KGD---------SMKI---ESST
IKESV-------SSG-----ILSVAFVSFLGM-----ESIL-NEAFFYNP--------EP
NMIRKSQK---------------LW--INSRV-VGGIITGS---KKDN-LSNP-VFYT--
-----L-ENIQAST---------------P-KK-KLDT

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

SI-CVS--WDPE-IEGG-RWTP
T-GCMML-DSTE-THTM-CSCNR-LA----NM-AII-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MA-S--GK--ITMD----FA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSLISHVGLILSLLCLAMAIATFLLCRSIQNR-NTTLHLHLCVCLF
LAKLLFL-IGADKTEN----------KTVCA---VIAGLLHYLFLACFAWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMPHLCAFGYGLPGLIVAVAAGIQWEGYGMHN---R-CWLNT-
-D------TGFAWSFLGP----VCIIIT--------------------------------
-----INSILLTWTLWIL-RKKLSSVNAEVST-L--KDS--RLLTFKAFVQLFILG--CS
WIL-GIFQ-IGP----IATIMAYLFTIINSLQGTFIFIIHCILNRQVRE--EYKRCFIRK
TKSSA-TSQTSGI-------LLSSVPSTSKAG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------FLLS-FFGA----VIPKIK---GECSECGPRA-------
------------------------------------------------------------
-----------------------------------------------------------G
PGHCTCDSGYISRSGQKLF-------------------------------T--FPLETCN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1067)

DINECEPPY-SVYCGSNAACHN-VEGSFHCRC-------VPGYRLQSGE--ERFSHSNEN
TCQEGKK------EVQ--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDTF----------------------------ESLLTNQ-TLWRTE------------
--------------------------------------------------GRQEISST-A
TTILRDV--E------S----------------------------KV-------L-----
----------------ETAL-------KAP-EQKVQ----------KI------------
----------QNS-SVGKTIMRPD------------------------------------
----------------------------------------------------T----HWG
LVSSW-------DLG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
MD--EKDRVF-----------------LNSKV-VSAAIGPK---RNVS-LSKS-VTLT--
-----F-QHVK------------------V-GH-RYTQ----------GT---------R
D-GSI-I-PVQE-SIT-M-----------------N-SFS---RS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
VAHLLFL-VGIDQTES-------K---VLCA---IIAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGIPAVTVAISAASRPHLYGTAD---Q-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLVFFILVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GFLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREI
VKSKS-ESETYTL-------SS-KVGPDS-KPSEGDV-----FP----------------
-----------GQVKRK-------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWHFSLL--------------
LFCXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXX--XXXXXXXXXXI-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------DECSLN
SSQCGPNSVCKNMPGRYKCSCLPGFSSPTG--NNWSPGKPGHFSCTDIDECLN-SRLCPE
HS------------------------ECV---SSLGGSHCQ-------------------
--CQDG-------------FVFINS---------LCKXXXXXXXXXXXXXXXXXXXXXXX
X------------------------------------X----------------------
------------------XXXXX-------------------------------------
-----------------------------------------XXXXXXXXXXXXXXXXXXX
XIDECL--D---MCLFNATCTN-IPGSYFYNC-------HPGFALSNRQ--L--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------TV----------------------P-FK-C-------K-ED-
M-I-PN-N-E-QV-Q-Q-CQ-V-G-A-A-L-G----------SEYVPFC-----------
----------ALMNATFSILDAACAKNTTI--VSLE---RTAEKFASVIE---KLSNCS-
SLTKDETSTVGTVLLESVESTV-LA--AFLKPSA------NSSQTIRTEFLDIESKVIED
ECTEENMVFN-MK------A-----------------RGN---------EMKI---GCST
IKESK-------STG-----TTGVALVSFASM-----QSVL-DESFFQDT--------QN
PLANSKRK---------------LK--MNSRV-VAGIMTGE---KKGG-FSDP-VIYT--
-----V-ENI---E---------------P-KQKF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

ERPI-CVS--WSTD-MGSG-RWTP
S-GCMVR-EVSE-TYTV-CSCNR-MV----NL-AII-MA-S--GE--LTXX----XX---
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---X-

PF00002 // ENSGT00900000140800_1_Domain_22 (2035, 2139)

CWLNT-
-E------TGFIWSFLGP----VCTIIM--------------------------------
-----INFILLTWTLWIL-RQKLSSVNAEVST-L--KDT---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MRG-
-R-----YFAFHS-----GLCVLLL-SLGT----IAQK---RRAACARCPRNAHCT----
------------------------------------------------------------
-----------------------------------------------------------N
ATSCRCDPGFTSLSGKVIF-------------------------------S--NPSEICT
DINECGPPL-YVSCGSLAHCHN-VEGSHYCEC-------ASGHELLSGG--TKFQSEKEN
TCQALNHTQTWSPD--------------------------------------M-------
VK----NNSHSSQTIHFMGKQCLSHHRYPVPSIE--GIL-----EIC-I-------SEY-
KY---------CP--NSTLLVSKSSTILLQQH----KGLIPTPLAGSDSQAPQW-T--S-
S

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DVDECSSGKHQCHNST--------HCINVK--GS-YRCYCHHDWVA----RSKPLRGLN
L----------------------------T-------ICEEVP-FSSWT-SPSGVSSQ--
-------------------------------------------------SLSHFFDK---
----------------VQQLSQDFK--PALAKNTIQD---LMQEVGELLE---IPGDLK-
ILTPSEQHCVATNLLIGLE-DI-LRVLSKFLPNGP-LTV---------------------
-HAPAGTELS-LK--VQE-Q-----------------GIGDVTLGQSDAKM-Q---LNWD
VVQES----SD--FG-----PSVVGLISMPGM-----GRLL-AEAPLVLD----------
--PEKQAVLH----GAHKGVLQGVSPVLLSDI-ISAFMSNR---HTQN-LSSP-VTFI--
-----F-SHHS-VT-----------------PG-PR

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

EEVF-CVF--WKHG-QNGYGHWST
T-GCRMV-ATRD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PL---
--------------LAAITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSA-SRVMKKLMFPVGYGAPAIIVAISAASRPHLYGTPT---R-CWLHT-
-D------KGFIWTFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIV-KNKLSSLDRDVST-L--QNT--RMLTFKATAQLLILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIVNSLQGVFLFLVYCLLSQQVRE--QYKKWFKGV
RKTKA-ESEKYTL-------SS-GTMSDA--SKHSEVR----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MAGLAR-------------LCAWRR-
-G-----SRRLLPGL----SVLLLL-SLGA----AAQK--PTAPCAPWCSQHSTCV----
------------------------------------------------------------
-----------------------------------------------------------S
ATACRCHPGFTSLSGEI-S-------------------------------S--SFEEPCE
DINECVPPM-TVSCGKMASCKN-VEGSYECEC-------SAGYMLPSGG--KTFRNESEN
RCQ---------------------------------------------------------
-------------------------------------------------DVN-E

PF00008 // ENSGT00900000140800_1_Domain_15 (1195, 1242)

CTSERT
P----------CH--SSAHCLNKVGGYQCRCR----PGW--

ENSGT00900000140800_1_Linker_15_17 (1242, 1262)

KPAPGSPHGPNTT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DEDECSSGKHRCHEST--------YCVNTI---GAYVCRCRRGWVPKPGCLNNQNTTV-
--------------------------------------CTESS-IPPWA-PPPGISSQ--
-------------------------------------------------TLSGFFDK---
----------------VQTLLRDFK--PTTAQSTIKG---LIQDVGDLLE---TPGDLE-
SLPRSEQHCVAAHLLAGLE-DV-LRGMSKALPNGP-LNA---------------------
-SAPAGTELS-LL--VQE-G-----------------GGDNVTLKLAKAQL-L---LDPD
VAQEP----GD--SG-----PSVVGLVSTPG-------KLL-AEAALVRE----------
--PGKQPL-H----EPLQVWPQARPPILLSSV-ISAFLGHK---VTKN-LSSP-VTFN--
-----F-AH-D-GT-----------------PR-PGQEVV

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CAF--WEHS-QDGCGHWAT
T-GCQML-GTTD-GST-TCRCTH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAQ--GDM--QDED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LAVITYVGLGLSLLCLFLAALTFVLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TGIDRIEP-------K---VLCA---IIAGTLHYLYLAAFAWMLLEGLHLFL
MARNLTVLNYSSV-SRFMKKSMFPVGYGVPAVVVTISAASRPHLYGTPK---R-CWLHT-
-D------NGFIWAFLGP----VCAIFS--------------------------------
-----INLAFFLMTFWIV-KTKLFSLNSEVST-L--QNT--RMLAFKATAQLFILG--CT
WCL-GMLQ-VGP----AAHVMLYLFTIVNSLQGVFIFLVYCLLSQQVRE--QYRNWFKGI
QGMKT-ESEKHTV-------TS-RIIPHA--SKPSTENYDQL-N----------------
-----------QM-SL------SPRKGRKS------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWGFWLL--------------
LFWGCSGVHRCG--MI---TLGQSLQ-----------GVNECEDTTTCPAYATCTDTKD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCT-CKRGFLSSNGQ--RNFRGPGVECQDVNECLQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
DSPCGPHSICINIPGRARCSCLSGFSSPTG--NSWILGSSSNFLCTDVDECLT-ARICPD
YS------------------------NCS---NSVGSYSCT-------------------
--CQLG-------------FTWNGL---------ACE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 854)

DKDECSEHSACPEHASCHNTLG
S-YHCTCDSGFEF

ENSGT00900000140800_1_Linker_10_11 (854, 872)

SGGGST-FQG--LEESCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 915)

DVDECSR---NS-TLCGLTLICVNTLGSY
NCSCPSGFSLSV--SKIPGHPVE-------------------------------------
--------------------------------------------------------SNCI
DIDE----C-DAMCPSNSSCTN-TPGSYFCTC-------HPGFAPSNGQ--VNFTDPE--
-----------------------------------------------VACK---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1322)

DIDECIQDPSPCGRNS--------VCTNVP---GSYICACLPSFRPD--------PE--
-

ENSGT00900000140800_1_Linker_17_18 (1322, 1452)

GSQA--HG-N-F-SCKR-I----------------------P-FK-C-------K-EDL
---IANS--E-QI---HQCLAGQ--A---GDL--------DYAS---FC-----------
----------T

PF16489 // ENSGT00900000140800_1_Domain_18 (1452, 1715)

LVNSTFGILDNTCENKSTP--VSLQ---NATRSVSLILE---QAPTWT-
ELSREETSALGTILLATVESIM-LA--SLLTPSG------NVSQTVQTEYLDIESKVINE
ECNGENVSFN-LK------A-----------------RGS---------EMKV---DCSI
IKESE-------STG-----NAGVAFVSFAHL-----DSVL-DERFFEVG--------QT
SW-----K---------------LK--INSHV-V

ENSGT00900000140800_1_Linker_18_21 (1715, 1779)

GGIVTGE---KKED-FSKT-IVYT--
-----L-QHI---Q---------------P-KQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVL--WNPN-VEDG-RWTR
S-GCEIT-KASE-TYTE-CSCNR-MA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGTVISLVCLALAIATFLLCRAVQNQ-NTYMHLHLCVCLF
LAKFLFL-VGVDKTDN----------QIACA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHLCAFGYGLPGLVVMISASVQPQGYGMHN---L-CWLNT-
-K------TGFIWSFLGP----VCTIIV--------------------------------
-----INSVLLAWTLWVL-RQKICSVSSEVST-L--KDT--RLLTFKAIAQIFILG--CS
WVL-GIFQ-IGS----IASIMAYLFTIINSLQGAFIFLIHCLLNRQIRD--AYRKLITRK
TEPSS-HSQTSGV-------LLLSLQSTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------ICFISALLLLGLSVL-------------------
-----------------LAP-----------SG-LEA-----KEAGVSCPPCPENANCLS
G--TCVCKDGFQFVSQKWF--LK-SV-QKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------ATG-LAKCKQKAYCRN-GIGNYYCSC-------VPHY-PLF-------------
-----NWV------ASI---------------------------------FTINH-----
---------------------------AECYGEN----------LQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------ETLRNNG---------------S-
K---NYIAKQVTQLLQHVELT-IWN-QSFVS---P-GKHENPVFD-----IVYETKKCNE
----TSEKTV-LE------A-----------------GNN---------TMNI---DCPN
AFKGT-------TRD-----RSAVALITYLSL-----GSVI-NGSFFSD--------RRG
-----IKE-----------------VNLNSQV-ISGSIGVK---EKVD-LSKP-VFLT--
-----F-QHTQ------------------P-GG-GRRKYF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKGS--KDGGGWST
E-GCSHL-GSND-SHT-QCKCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL----A--PKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTMITYVGLSLSLLCLLLAALTFLLCRSIQNT-STTLHLQLSICLF
LAHLLFL-VGIDQTEP-------E---VLCK---VVAGVLHYLYLAAFTWMLLEGLHLFL
TVRNLKVANYTTA-GRFKKRFMYPVGYGVPALIVAVSATVGHKNYGTY---TH-CWLKL-
-D------KGFIWSFMGP----VALIIL--------------------------------
-----INLVFYFQVLWIL-RSKLSSLNKEVST-I--QNT--RVMTFKAISQLFILG--CS
WGL-GFFL-VEEVGKTIGSIIAYMFTIINVLQGTLLFVVHCLLNHQVQM--EFKKWFSGV
RKGVE-TE-SSEV-------FR-SATQTK-MEKLE-KSS-EFFCERDSAS-I-----QPP
PGP--------HLVGISWFKTDN-------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MAAL----AG-----------------------------------------------
------------------------------------------------------------
-------------------LHTMRNRY-------LRLLPASGLLLLFLPLGFAALETRSC
AWWCPPNPPCIN---ADNCRCFPGFGSSSE--VTFTG---PLESCDDINECGPSWNVSSE
IHIDCQDFNESYSLCKK-----------------GNSLLS-------------HEMFVNE
CRS----MTSGLEALLI------IT-LKTAAEKLKASDPT---ECAQWCPPNSKCV----
------------------------------------------------------------
-----------------------------------------------------------N
ANSCRCTLGFNSSSGEI-I-------------------------------T--SHSESCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECEPPS-TVSCGKFAQCWN-TDGSYYCTC-------SPGYQLVSGA--TMFRKESEN
TCQV--------------------------------------------------------
---------------------------------------VKPENTTKDQDSEKCCVRPE-
------------------QDDKNTPTYTLGDL----DKQ--KRL---PSGPDSN-R--D-
HHKEPLPQGQTSPKEVKPG-----SMGGQTD---GGQK-KAKPHWQEAK-----------
----------------------------------------GII-FPTWA-APSRVKSK--
-------------------------------------------------RLSRFFDR---
----------------VHYLSRNFN--SASVQSTVQE---VIQEVDEMLE---SPGDLG-
NLAPTEQHSVATNLLFGLE-NV-LRGLSKALHNGS-ATF---------------------
-TSSAGTEFS-LK--VME-E-----------------EDRTITLTQNQTKM-L---LTWD
TLHES----SD--SG-----PIVVGLVSTPGM-----RKLL-ANVSLVLD----------
--TEEEIVLH----ESQMVLRQEISPILLSNV-VSAFINLN---NTQN-LNSP-VTFI--
-----F-QH------------------SVT-LG-PRQKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WENS-QNGSGHWAT
N-GCKMV-GTKD-NST-ICQCTH-LS----SF-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--YEV--QEEN----TS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LNVITYIGLTLSLLCLLLAALTFLLCKPIQNT-STSLHLQLSICLF
LAHLLFL-IAIDRTEI-------K---VLCS---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLMVVNYSSV-NRFMKKLMFPVGYGVPAVIVTISAATRPHLYGTSS---R-CWLHT-
-E------EGFIWTFLGP----VCTIFS--------------------------------
-----INLVFFLITFWIL-KNKLSSLNNDVST-L--RNT--RVLTFKATAQLFILG--CT
WC-LGILQ-VGP----AAHVMAYLFTIINSLQGVFIFLVYCLLSQQVRD--QYRKWYKRV
KETKT-ESEEYTL-------SS-KTISDP--SKHSMEVRISG-S----------------
-----------QTPLASNFQFPDPK-D-NNFWKLAERGLN----------PSMLFIYHTT
GSFCSK-----TYE--------AWGARRLTSTLQTCKG---------------KHKPLK-
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------SCCL

PF07645 // ENSGT00900000140800_1_Domain_1 (398, 434)

DVNECADTTTCPAYATCTNTVGS
YYCT-CKQGFLSS

ENSGT00900000140800_1_Linker_1_4 (434, 450)

NGQ--KQFRGPGVECE

PF07645 // ENSGT00900000140800_1_Domain_4 (450, 1066)

DIDE---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----CV-----DMCPLRSDCTN-TPGSYSCTC-------HPGFAPSHGQ--RHFRGQG-------------------------------------------------VECR----------------------------------------------------------------------------------------------------------------------------------DVDECSQDPPPCGPNA--------VCTNTP---GSYSCRCTAGFRPH--------HE---GSQT--QA-N-F-TCQR-I----------------------L-FK-C-------K-EDM---IPHN--K-QA---QQCQAGA--P---VEL--------EYVSILPFC---------------------ALMNDTFHVLDKTCENKSAV--S-LQVTPFISPQFQVSGGRFRNLMGKN-SVTNSGHSCWCETFQNIFPSFL-VT--GKYRPLL--------PSARTAVLVDIESKVIKEDCLEENG-FS-LK------A-----------------KGD---------GMKI---SCSMIKESR-------SSG-----STGVAFVSFANM-----ESVL-DERFFRGP--------QSPRANVELR---------------LR--MNSRV-VGGITTGE---KKDN-LSEP-VLYV-------L-ENL---Q---------------P-KQ-KSERPI-CVS--WSSD-VGDG-GWTP

PF07645 // ENSGT00900000140800_1_Domain_9 (450, 1066)

DIDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CV-----DMCPLRSDCTN-TPGSYSCTC-------HPGFAPSHGQ--RHFRGQG--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1322)

DVDECSQDPPPCGPNA--------VCTNTP---GSYSCRCTAGFRPH--------HE--
-GSQT--QA-N-F-TCQR-I----------------------L-FK-C-------K-EDM
---IPHN--K-QA---QQCQAGA--P---VEL--------EYVSILPFC-----------
----------ALMNDTFHVLDKTCENKSAV--S-LQVTPFISPQFQVSGGRFRNLMGKN-
SVTNSGHSCWCETFQNIFPSFL-VT--GKYRPLL--------PSARTAVLVDIESKVIKE
DCLEENG-FS-LK------A-----------------KGD---------GMKI---SCSM
IKESR-------SSG-----STGVAFVSFANM-----ESVL-DERFFRGP--------QS
PRANVELR---------------LR--MNSRV-VGGITTGE---KKDN-LSEP-VLYV--
-----L-ENL---Q---------------P-KQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSSD-VGDG-GWTP
A-GCEVL-KVLE-THTV-CSCNR-LA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-L--EE--LPVA----VS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LEIISLVGLSLSLVCLVLAIATFLLCRAIRSR-NTSLHLHLCVCLF
LAKILFL-TGVDKTDN----------QTGCA---IIAGCLHYLFLACFSWTLVEAVTLFL
MVRNLKVVNYFSS-HNISMLYLCAFGYGFPGLVVAISASMYLQGYGTHN---R-CWLST-
-A------RGFIWSFLGP----VSVIIL--------------------------------
-----INFVLLTWTLCIL-RQKLSSVNAEVSK-L--RDT--RLLTFKAFAQFFILG--CP
WVL-GFFQ-IGQ----MASIMAYLFTIINSLQGMFIFVIHCLLSRQVRE--EYRRWLTRK
TKPSS-QSQTSGI-------LLSSMPSSSKTVRVC-CAP--RALVRGMPTAL--------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MQGPLL---LPGLCFLLS-LFGA----VTQKTK---TSCAKCPPNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NTHCTCNHGYTSGSGQKLF-------------------------------T--FPLETCN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECKPPH-SIYCGLNAACHN-VEGSFYCRC-------VPGYRLRSRN--EQFNNSNEN
TCQDTTSSETTQGRKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDEF----------------------------ESLLTNQ-TLWRTE------------
--------------------------------------------------GRQQISST-A
TTILWDV--E------S----------------------------KV-------L-----
----------------ETAL-------KAP-EQKVL----------KI------------
----------QND-SVAIETRVITD-------NCS-------------------------
---EERRTFN-LN--VQ-----------------------M-------NSMDI---GCND
IIQGD-------TQG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
MD--KKDQVY-----------------LNSQV-VSAAIGPK---RNVS-LSKS-VTLT--
-----F-QHVK------------------M-NL-STKKVF

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVY--WKST--GQGSQWSR
D-GCFLI-HVNK-SHT-MCNCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAL---TS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSVSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LGHLLFL-VGIDRTEP-------K---VLCS---IIAGALHYLYLAAFTWMLLEGGHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTAD---R-CWLHL-
-D------QGFIWSFLGP----VCAIFS--------------------------------
-----VNLVLFISVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GLLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYRKWFREI
VKSKS-ESETYTL-------SS-KMGPDS-KPSEGDV-----FP----------------
-----------GQAKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWSFSFL--------------
LFWGCCGIYTWG--MFTLPSLESMARH-----------MNGCTDTTMCPAYATCTNTSTS
YYCT-CKKGFLSSNGQ--TKFRDPQVECKDIDECSQSHPPCGPNSI--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------CRNLPGRY
KCNCLPGFSSPTGNNWNPGKPGHFTCT-

PF07645 // ENSGT00900000140800_1_Domain_12 (929, 1019)

DI--------NECLDS--GICPEHSECTNSLG
SYRCSCQVGYT------------------------------------------SKNSSCE
DVDECA--D-PRTCPKHSTCHN-SLGSYSCAC-------NPGFESSRGK--MSFQGLG--
-----------------------------------------------ETCEDVDECSRN-
STLCGPSSVCTNILGKY-SCSCLPGFFSPGLWSP--E---KPEAFKC-------------
------------------------------------------------------------
------------------------------------------------------------
-----------------RGV----------------------L-FK-C-------K-EDV
---IPNN--E-WA---QLCQVGA--A---VEP--------GYVS---FC-----------
----------ALMNATFGILDGVCKNKTTV--VSLK---STAESFASVIE---QTSVWS-
NFTKEKTSTLATVLLESVESAT-LA--ALLKPSA------NVSQTIQTDHLDIESKIINK
GCTEENEVFS-LK------A-----------------KGD---------EMKI---RCST
IEESE-------STG-----VSGVAFFSFAGM-----ESVL-DERFFQDP--------QT
HLANSKRK---------------LK--LNSRI-AGGIITGE---KKDG-FSKP-VTYT--
-----L-ENI---E---------------P-KR-NF

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

ESPI-CVS--WSTD-VEGG-RWTP
S-GCAVL-EVSE-THTG-CSCNR-MV----NL-AII-MA-A--GE--LTXX----XX-----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX-XXXXXXXX----------XMGCA---IIAGFLHYLFLACFFWMLVEAVMLFLMARNLKVVNYFSS-RNIKMRYLCAFGYGLPALVVAVSAVIQPQGYGMYN---R-CWLNT--E------TGFIWSFLGP----VCTIIV-------------------------------------INSILLTGTLWIL-RQQISSVSTEVSK-L--KDT--RLLTFKAFAQIFILG--CSWVL-GIFQ-FGP----MANIMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYRRCMTRKTKPSS-RSETSGI-------VLSSVPSTSKTG----------------------------------------------------------------------------------------------------------------------------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1804, 2207)

CAVL-EVSE-THTG-CSCNR-MV----NL-AII-MA-A--GE--LTXX----XX---
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXX----------XMGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MARNLKVVNYFSS-RNIKMRYLCAFGYGLPALVVAVSAVIQPQGYGMYN---R-CWLNT-
-E------TGFIWSFLGP----VCTIIV--------------------------------
-----INSILLTGTLWIL-RQQISSVSTEVSK-L--KDT--RLLTFKAFAQIFILG--CS
WVL-GIFQ-FGP----MANIMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYRRCMTRK
TKPSS-RSETSGI-------VLSSVPSTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MESVEI-------------EAPFSYL
CH----------LCLSAPGLLVLLL-FPMGPT---AQN--S-KACALWCPPNSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTACRCTPGFISFSGEI-F-------------------------------T--DPLETCN
DINECGPPS-PVDCGSSADCQN-TEGGHHCTC-------SPGYEPVSGP--AVFRNESEN
TCR

PF07645 // ENSGT00900000140800_1_Domain_14 (1084, 1187)

DVDECQH-------------------------------------------------R
PRVCKGRSICINTKGSY-TCQCPPGLEFN----P--EDP-----RHC-TDVN-ECVSGRK
P----------CH--NSTHCLNSVGSFECRCR----PGW--KPIPGSPNGPNNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1311)

DADECSSGQHRCHSST--------ICVNTV---GSYTCHCRQGWVPRPGFQDKQKNTIC
E---------------------------------------EIS-FPTWT-APSGIKSQA-
--------------------------------------------------LSHFFNR---
----------------IQDLRRNFS--SASVLNTVRD---LVQEVGDLLE---TPGDLK-
TLPFSEQHFVVTNLLFGLE-NV-LRGVSKALPKGS-FTF---------------------
-GSSAGIELS-LE--VQA-P-----------------SYRNITLIQNQTKM-M---LTWD
TVHDP----GD--SG-----LAVVGLLSAPGM-----DRFL-AEAPLVLD----------
--AEEPTALR----ETHRGLLQETSHILLSDV-ISAFITNK---DTEN-LRSP-VTFV--
-----F-QH------------------SVT-PG-PREK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

VH-CVY--WEHG-QNGSGHWDT
R-GCWVA-STRD-NST-TCQCTH-LS----IF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAH--YSV--QEED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2046)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAFDRTEN-------K---VLCA---VIAGALHYLYLASFTWMLLVGLHLFL
SARNLTVVNYSGI-NRFMKKAMFPVGYGVPAVIVAISAASRPHLYGTPT---R-VQKTE-
-HCIFLSHGQPEVLFFEP------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------S

PF07645 // ENSGT00900000140800_1_Domain_15 (1198, 1259)

GQN
L----------CH--SSTHCLNKVGSYECQCR----PGW--KPIPGSPNGPTDT-V--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DVDECSSGQHRCHPST--------VCTNTV---GSYRCRCRPGWKPKPGLPNNQNITV-
--------------------------------------CEG-------------------
-------------------------------------------------GLSRFFEK---
----------------IQYLGRDFK--PASAPGTIKD---LMQNVDELLE---TPGDLE-
SLSRSQQCCVATNLLVGLE-AV-LRELSKLLPDGL-LNY---------------------
-S--AVTELS-LK--VQE-Q-----------------GDGNVTLSQTQAKM-Q---LNWN
LAQKS----GDTDNG-----PSAVGLVSIPGM-----GKLL-AEAPLVLE----------
--PEQLAALR----ERHKGWLQDARPVLLSHV-NAAFLSNK---DTRN-LSSP-VTFV--
-----F-SHR-SVI-----------------PG-PRQKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CAF--WKPG-QKGCGHWAT
T-GCRTV-DPRD-TST-TCHCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--CDV--QEEA----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSG-SRFMRKLTFPVGYGIPAVIVAISAASHPHLYGTPA---R-CWLNP-
-E------KGFIWGFLGP----VCAIVS--------------------------------
-----VNLAFFLMTLWIL-KSRLSSLNSEVST-L--QNT--RMLTFKATAQLFILG--CT
WCL-GMLQ-VGP----AAQVMACLFTVTNTLQGVFIFLVYCLLSQQVRE--QYRKWFKGI
RKSRA-ESEVYVL-------SS-RATSDT--SSPSTVRTRTA-P----------------
-----------RAHH---------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------LCVLVL-LKTA----VFQNTKDSQCRRRGCPQNAICI----
------------------------------------------------------------
-----------------------------------------------------------N
KTHCACEDGFVTTSGEKYF-------------------------------S--DFLEICD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1075)

DVNECVPPI-KIFCGMNADCVN-TYGSYHCTC-------IPGYALPSGE--KNFPNASMN
NCQGKKTCSFPPHTGL--------------------------------------------
--------------NNF---------L------L--T-----------------------
-----------------------------------------EPMPGRTLHFREN-ITKAE
EQNSKF----------------------------NTVLSRC-LFPSPG------------
--------------------------------------------------VPPPIMSSHL
HMFVQYV--Q------K----------------------------TFFVSKSLLIKS---
-----ILF-------LFFSIERSHQNQPSS-LSVLL-------TFQHI------------
----------QNSSLLKIVEEIIFM-------NVR-FFF----TSLM---------SF--
-HAPHVRIFL-LI--QEK-------------------GWEML------TIFQK---HQNL
KLRSH-------VQA-----QKCLIKDLLVSI-----YLI--QNNEYLLEG------SGG
MKGEKKNKIKKVHSREIKGCKRRGKKKMNSLLFLKSIIDPC---LHPS-LH----TFH--
-----L-CRSQ------------------K-KK-EEER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

SL-CVY--WEAQ-GEEGGAWST
K-NCNLI-ESNK-THT-RCNCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1856)

MDL---QQ--QDED----

PF00002 // ENSGT00900000140800_1_Domain_22 (1856, 2196)

YV---
--------------LTVITYVGLSLSLLCLFLAILTFLLCHTIQNT-STSLHLQLSLCLF
LANLLFL-IGIKQTKI-------K---VLCS---IIAGLLHYFYLASFTWLLLEGLHLFL
TARNLMVANYSRV-NHSLRKVMYPLGYGIPAVIVAISAASRANLYGTSS---Q-CWLQT-
-Q------EGFLWAFLGP----VCIIFS--------------------------------
-----INFVFILLIIWIL-QSKLSSLNNEVST-L--QDR--RLLRFKALTQLCILG--CT
WCL-GILQ-IGP----AARIMRYLFTIINSLQGVFIFLVYCLLNHQVQE--QYKKWFKTL
RPTKS-ES--FML-------SS-KVVSGS-TQNHTVRK-TTAFL----------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SLMVA-----TGDMGI----------SYQLHATALGIL----------------------
----------------------------LVWSV-LQL-----QNISASCPQCNENAYCYN
S-SHCICKDGFWSEPDNRK-IIK-PH-VRCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QLE-PSVCIDVSYCKN-KVGTYICSC-------IVKY-PIF-------------
-----NWV------AGI---------------------------------TDIDS-----
---------------------------PECYVRK----------PEN-IK-N-SA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------DVWGKL---I---------------G-
RESKKDVAKAATEVLHEVEVH-VLN-ENSAA---A-TKGENSELG-----IVYETKRCKS
-------MTL-LE------A-----------------GNN---------TMKI---DCNS
VLKET-------KSR-D---ETPVALIAYQSL-----GKFL-NGSYFSN--------KEG
-----VTE-----------------VKLNSLI-VSAAIRSE---VKPV-LSEP-VILT--
-----L-QNIQ------------------P-ID-PRAEHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEGS--EDGGSWST
K-GCSHM-HTND-SYT-TCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---S---LEED-SVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSVITYVGLSLSLLCLFLAAVTFVLCQPIQNT-STTLHLQLSICLF
LADLLFL-TGINRTEP-------K---VLCS---LIAGMLHYLYLASFMWMLLEGLHLFL
TVRNLKVANYSSS-GRFKKRFMYPVGYGIPAFIVAVSAIARHKNYGTH---TH-CWLSL-
-D------KAFIWSFLGP----VAAIIL--------------------------------
-----INLVFYFQTIWIL-RSKLSSLNKEVST-L--QDT--KIMTFKAIVQLFVLG--CS
WGI-GFFM-VIEFGKTVKLIIAYLFTIINVLQGVLIFVVHCLLNRQVRV--EYKKWFRKM
HKGVE-TE-STEM-------SC-STTHTK-M-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMDIWE--THTGPTLKPTI-----------KSANKCRETTTCPAYATCTSNMDS
YYCT-CKQGFLSSNGQ--KYFKGPGVECKDIDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQPCGPNSVCKNLSGRYSCHCLHGFSSPIG--NHWISGKPGNFSCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 815)

DINECLT-SGICPE
RS------------------------DCV---NFMGSYFCS-------------------
--CQVG-------------FISRNS---------

ENSGT00900000140800_1_Linker_9_10 (815, 819)

SCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECLNPRACPEHATCLNTAG
A-YTCLCNPGFESSSGHLS-FQG--LRELC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECI-----EMCPINSTCTN-TPGSYFCTC-------HPGFAPSNGQ--LNFTDRE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1322)

DVDECLQDPSTCGPNS--------VCTNAL---GSYNCGCIAGFRPN--------SE--
-GSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDM
---ISNN--E-QA---QQCQEGT--T---MKP--------EYVL---FC-----------
----------ALINDMFDILDNMCENKTTV--VSMK---SMAESFVPVLE---QMSTWT-
NFTKKQTSSLATVFLENVESTA-LA--AFLRPSE------NATQTVQTEYLDIESKVIDK
EYKEENVTLS-LA------A-----------------KRD---------KMKI---RCST
IKESE-------SRG-----TTGVAFVSFVGM-----ESVL-DERFFHNP--------QT
PLANSEVK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WRTD-VEGG-RWTP
S-GCVVL-EASE-VHTI-CSCNH-LA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYVISHVGIIISLVCLILAIATFLLCRSIRNH-NTYLHLHLCVCLL
LAKTLFL-AGIDKTDN----------QMGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMPYLCVFGYGLPGLVVVISASVQPQGYGMYN---R-CWLNT-
-E------AGFIWSFLGP----VCTVIMI-------------------------------
------NSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-FGP----AAGVMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYKRWITGK
TKPSS-ESQTSRI-------LLSSMPFTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHIRPTRKPN------------TKG

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NNCRDSTLCPAYATCTNTVDS
YYCT-CKRGFLSSNGQ--NHFKGPGVQCKDIDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQPCGPNSSCKNLSGRYKCSCLHGFSSPTG--NDWVLGKLGNFSCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 816)

DINECLS-STVCPE
HS------------------------DCV---NSMGSYSCS-------------------
--CQVG-------------FISRNS---------T

ENSGT00900000140800_1_Linker_9_10 (816, 819)

CE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECADPRACPEHATCNNTVG
N-YSCFCNPGFESSSGHLS-FQG--LEASC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECT-----EMCPINSTCTN-TPGSYFCTC-------HPGFAPSNGH--LNFTDQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1323)

DIDECRQDPPTCGPNS--------ICTNAL---GSYSCGCIAGFHPN--------PE--
-GSQK--DG-N-F-SCQR-V----------------------L-FK-C-------K-EDM
---IPDK--K-QI---QQCQEGT--A---VKP--------AYVS---FC-----------
----------AQINNIFSVLDKVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESMT-LA--SFWKPSA------NVTPAVRTEYLDIESKVINK
ECSEENVTLN-LV------A-----------------KGD---------KMKI---GCST
IEESE-------STE-----TTGVAFVSFVGM-----ESVL-SERFFQDH--------QA
PLTTSEIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-TYTV-CSCNQ-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGIIISLVCLVLAIATFLLCRSIRNH-NTYLHLHLCVCLL
SAKTLFL-AGIHKTDN----------KTGCA---IIAGFLHYLFLACFFWMLVEAVILFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPMLVVVISASVQPQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIV--------------------------------
-----INSLLLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNGQVRE--EYKRWITGK
TKPSS-QSQTSRI-------LLSSMPSASKTVRDC-MLP--AGAGRGRCRPLGDTQLCHV
LGTEW--ELRVPTLVSSWM-KCGVED--WGFICIY-------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MQGSSLLPGLCFLLS-LSGV----VAQKTK---GTCRSCPPLSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATHCTCNHGYISESRQRYF-------------------------------T--YPLETCK

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECTPPI-SIYCGVNAECQN-TKGSFYCQC-------KAGYKALSGK--AQFNNANEN
TCQKTTPSETTSGTKK--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQQ-------
-VVENI----------------------------KSLLTNE-TVWGTE------------
----------------------------------------------------RRKTTT-F
TSILQKI--E------S----------------------------VV-------L-----
----------------EAAL-------KAP-DQKLQ----------KV------------
----------QNR-TVAVETRVVTD-------NCS-------------------------
---TGVIFNL-S---AL-----------------------M-------NSMNI---SCSD
IIQGN-------TQX-----XXXXXXXXXXXX-----XXX--XXXXX-XX---------X
XX--XXXXXX-----------------XXXXX-XXXXXXXX---XXXX-XXXX-XXXX--
-----X-XXXX------------------I-KS-SI

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

KKVF-CVY--WKGT--KEGGHWST
E-GCFLI-QANK-THS-ICNATH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAI---DT--QEKD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2213)

-PT---
--------------LTVITYVGLSLSLLCLLLAALTFLLCKAIQST-STSLHLQLSLCLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLYLFL
TARKLTVVNHSSI-NRFMKKLMFPVGYGVPAVIVTISAASRPHLYGTPD---H-CWLGL-
-Q------KKFIWALLVT----LGVTIC--------------------------------
-----XXXXXXXXXXXXX-XXXXXXXXXXXXX-X--XXX--XMLTLKATAQLFILG--CT
-CL-GVLQ-LGS----AAPVMDYLSTIINSVQGVI--LVCCLLSQQ------VRKWFGEI
IKSKS-EPETHTL-------SS-RFGPDS-KPSEGGGF-----P----------------
-----------GQVY---------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWTFSLL--------------
LFWXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXX--XXXXXXXXXXV-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------DECSAT
PSLCGPASLCKNLPGVYKCSCFPGFSAAHR--TTWVPRKTGRLTCS

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 816)

DVDECLN-SSICPE
NS------------------------DCV---NSVGSYSCS-------------------
--CQAG-------------FVSRNS---------TCE-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
DVDECI--A---TCDFKATYNN-TPGSFFT-S-------YPGFALNNGH--LSFMDQV--
-----------------------------------------------VECL---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECFQDQLLCGLNS--------VCTNVL---G-YNCRCMVEFRPD--------P-E-
S-SW-K-DR-N-F-NC-KRV----------------------T-LK-C-------K-ED-
V-I-PD-N-E-QV-Q-K-CQ-G-R-A-A-M-G--------PGNVTVPFC-----------
----------AIMNATFSVLDGACENKTTA--VSLE---GAVESFASVLE---ETDTWS-
NFTKEETSTLATIVLESVENTV-LA--AFLKPSE------NDSQTIQTESVDVDSKVIKE
ECNEEEAFLN-LK------A-----------------KGD---------GMKI---RCST
IEESE-------SAG-----TTGVALVSFSGM-----ESIL-DERYFQDP--------QD
YLTNS-KK---------------FR--MNSRI-IMGVMTGE---KKDG-FSET-IIYS--
-----L-ENT---Q---------------P-KQAL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1848)

EKPM-CVS--WSTD-IEGG-RWTP
S-GCLVL-NASE-MHTT-CSCNR-MG----NL-AII-MA-S--SE--

ENSGT00900000140800_1_Linker_21_22 (1848, 1855)

PTME---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-FS---
--------------LYVISHVGMIISLVCLALAIATFLLCRAIRSH-NTHLHLHLCVCLF
LAKSLFL-VGIDKTDNKXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---X-XXXXX-
-X------XXXXXXXXXX----XXXXXX--------------------------------
-----VNTILLTWTLWNL-RKKLSCVNTDIST-L--KDS--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----IASLMAYLFTIINSLQGALIFLIHCLLNHQVRE--EYKRWITRK
TKSSS-QSQTSGI-------LLSSVSSTSKM-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
GSRCLVLLSGVSVLLALSSSEVK-------------------------------------
--NSGA--F-CPPCPKNAGCHN-R---THCAC-------HSGFQSMSGK--KYFMESS--
-----------------------------------------------EKCE

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1166)

DIDECKSG-
MANCKGRAYCKNTDGSF-YCSCIITYP---I-FN--WVADI---FNF-------------
---------------------------------------------------------DQ-
PEC---------------------------------------------------------
----------------YG-I----------------------P-FR-S-------K-GNM
---TSRN--K-LV---QRCQEKA--V---SVR--------TQDS---YC-----------
----------GLMSSTFSIVNDAWKT--TT--SSLK---ETAKHFGGVLK---ERHTWS-
KFSKEETSLLGTFLLESVESTT-LA--AFLKPSA------NASQSIQTEYLDIESKVIKE
ECTGENITFN-LK------A-----------------KGD---------AMKI---GCST
VQESQ-------SSV-----TTGVAFASFEGM-----ESVL-DERFFQDP--------QD
PLANSKRK---------------LK--MNSRI-VRGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-QS-RFPHTQ-CRSYHWIGN-IKHS-KYVK
S-GVRQL-KDSK-LYIF-CSCIH-RVGHRTGV-GIM-AG-G--SQ--CMME----

PF00002 // ENSGT00900000140800_1_Domain_22 (1856, 2196)

YS---
--------------LSIISHVGLVISLVCLVCAIATFLLCRSIRNH-NTDLHLHLCVCLF
LAKILFL-TGVNRTKK----------KLGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNVKMRHLCVIGYGLPGLVVLVSASVQPKGYGMHD---R-CWLST-
-E------SGFIWSFLGP----VCTIIM--------------------------------
-----INSILLTWTLMIL-RQKLSSVSAEVST-I--KDT--RLLTFKAFAQVFILG--CS
WVL-GIFQ-IGA----MARVMAYLFTIINSLQGAFIFLIHCLLSRQVRE--EYRRWFTAK
TKPSS-QSQTSGI-------VLSSVPSSSKTVRAR-MF----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MELIH--SRHSDRILLET
DCSQH-----LSAMRS----------SFLV--LLLSGLIVL-------------------
----------------------------LALPR-SEA-----KSYRAPCPSCPEHAYCHN
S-THCTCEHGFQSRSGRTY-FHE-DN-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1060)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KTG-LAKCKYRAYCKN-KIGSYICSC-------WSS--ILI-------------
-----NWA------AGV---------------------------------LINDD-----
---------------------------PDCYENN----------DSQ-GT-Q--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SN--VDIWENLRR-------------------
NASRKEFARKATQLIQNIELS-IWN-ATFAS---P-KKDQISEFD-----LVYETKRCNE
----TRENTF-LE------A-----------------GNN---------TMDI---NCAD
AFKGS-------LRE-----STAVALITYQSL-----GNIL-NASFFSK--------RKG
-----MEE-----------------VKLNSRV-VSGTIGLK---EKVY-LSEP-VFLT--
-----F-QHHQ------------------P-GD-ERTKHI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WEGS---EGGSWSR
E-GCSHV-HSND-SYT-KCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-LAL----A--PKED----AV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITQVGLAISLLCLFLAILTFLLCRPIQNT-STSLHLQLSLCLF
LAHLLFL-TGINRTEP-------E---VLCS---MIAGLLHFLYLASFTWMLLEGLHLFL
TVRNLRVANYTST-GKFKKRFMYPVGYGIPAVIIAVSAIVGPKNYGTF---TH-CWLKL-
-D------KGFIWSFMGP----VAVIIL--------------------------------
-----INLVFYFQILWIL-RSKLSSLNKDVST-I--QDT--RVMTFKAIAQLFILG--CS
WGL-GFFM-VEEVGKTIGSIIAYSFTITNVLQGVLLFVVHCLLNRQVRM--EYKKWFSGI
RKGVE-TE-STEM-------SR-STTQTK-TEEVG-KSS-EFFHKGDTPSSAADSAKHLQ
PQV--------HLVSATWLKMN--------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGECEAE-WG--ARG-------------------GLG

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NNCRDSTMCPAYATCTNTVDS
YYCT-CKQGFLSSNGQ--NHFKGPGVQCK-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------DINECLT-GRVCPE
HS------------------------DCV---NSMGSYNCS-------------------
--CQVG-------------FISRNS---------ICE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECADPRACPEHATCNNTVG
N-YSCFCNPGFESSSGHLS-FQG--LKASC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECT-----EMCPINSTCTN-TPG

PF12662 // ENSGT00900000140800_1_Domain_14 (1047, 1265)

SYFCTC-------HPGFAPSNGQ--LNFTDQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECRQDPSTCGPNS--------ICTNAL---GSYNCGCIAGFHPN--------PE--
-GSQN--DG-N-F-SCQR-V----------------------L-FK-C-------K-EDV
---ISDN--E-QV---QQCQEGT--A---VKP--------AYVS---FC-----------
----------AQINNILSILDKVCENKTTV--VSLK---NTAESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESMT-LA--SFWKPSA------NVTLAVRTEYLDIESKVINK
ECSEENVTLN-LV------A-----------------KGD---------KMKI---GCST
IEESE-------STG-----TTGVAFVSFVGM-----ESVL-NERFFQDH--------QA
PLTTSEIK---------------LK--MNSRV-TGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VEGG-RWTS
F-GCVIL-EASE-TYTV-CSCNR-MA----NL-AVI-MA-S--GE--LTMD----FS---
--------------LYVISHVGIIISLVCLVLAIATFLLCRSIRNH-NTYLHLHLCVCLL
LAKTVFL-AGIEFHHI----------GTGCA---IIAGFLHYLFLACFFWMLVEAVILFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLLVVISASVQPQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCAVIVVSKYY

PF00002 // ENSGT00900000140800_1_Domain_22 (2074, 2196)

NSLAKCVLKEEQGDLVTYSRQ----KF
SFPGQINSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNHQVRE--EYKRWTIGK
TKPSS-QSQTSRI-------LLSSMPSTSKMVRDY-TGW--AR------------WLTPV
IPTLW--EAEVGRLPEARSSRPTWPT--WQNPRLY-------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------RPVPV-----AALCVLLA-LSEA----EAQD---AGGCDRWCPPNAMCA----
------------------------------------------------------------
-----------------------------------------------------------N
TTACRCKPGFSSSGAEI-F-------------------------------T--DFMVSCD
GTAAWGRCL-RGPCGHLDTCLN-PEDAARSGA-------TRGVI--PAL--P---LADVD
ECQQ------------------------------------------------S-------
PRVCGSLGVCRNTLGSHA-CHCPPGFALQ----P--RDP-----KLC-A

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1249)

DVD-ECALGQH
Q----------CH--NSTLCLNNVGGYECRCR----PGW--RPVPGSP

ENSGT00900000140800_1_Linker_15_17 (1249, 1262)

DGPTDT-V--C-
A

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1318)

DVDECSSGQHRCHPST--------FCVNAV---GSYTCRCRPGWRPKPGVPNNQNITV-
--------------------------------------CQETP-FTNWTEPPPGIRSQ--
-------------------------------------------------SLSRFFNK---
----------------IQDLDRDFK--PDSAQ---KT---LMENVHELLE---TPGDLE-
TLLRTQQHCVAGHLLVGLE-DV-LRRLSKSLPDGP-LTV---------------------
-SCPAGTELS-LK--VLK-Q-----------------RDGNVTLSQTQAKM-Q---LNWT
LAQKV----GDT------------------GM-----GKLL-AEAPLVLE----------
--PE-LTALQ----ERHKGWLQDAHPTLLSYV-SSAFLSNK---DTQN-LSSQ-VTFI--
-----F-SHLSSVI-----------------PG-PRQKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CAF--WKPD-QKGYGHWAT
T-GCRML-DLRD-TST-TCHCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--YHV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LAVVTYVGLGLSLLCLLLAALTFLLCRAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------Q---ALCA---LVAGALHYLYLAAFAWMLLEGLHLCL
AARNLTVANYSGT-NRRVRKLMFPVGYGVPAVIVAISAASHPHLYGTPA---R-CWLNP-
-E------KGFIWAFLGP----VCAIFS--------------------------------
-----VNLAFFLMTLWIL-KSKLSSLNSEVST-L--QNT--RMLTFKATAQLCILG--CT
WCL-GMLQ-VGP----AAQVMAYLFIIINSLQGVLIFLVYCLLSQQVRE--QYRKWFKGM
RKLRA-ESEVYMI-------SS-RATSAD-TSSPST------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------KFYFM--------------
IF---PCLYSYS--PISGPL---TL-------LCSLP

PF07645 // ENSGT00900000140800_1_Domain_1 (398, 435)

DIDECHTSGVCPEHSHCANSVGS
YSCN-CQAGFISIK

ENSGT00900000140800_1_Linker_1_4 (435, 450)

S-----------TCE

PF07645 // ENSGT00900000140800_1_Domain_4 (450, 686)

DVDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PPACGPHSVCENMPGTYRCSCLSGFSSPTG--NGWIPGNPGNFGCTDIDECHT-SGICPE
HS------------------------HCA---NSVGSYSCI-------------------
--CQVG-------------FISSES---------TCE-E

PF07645 // ENSGT00900000140800_1_Domain_10 (820, 853)

VDECANPGACPEHATCSNTLG
N-YSCVCNPGFEPSGGPLT-FLG--VGGSC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECA--A--SRCPANAACAN-TPGSYFCTC-------HPGFAPSSGQ--PSFADQR--
-----------------------------------------------VTCT---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1318)

DADECSQDPSPCGPHS--------VCTNVP---GSYSCSCAGGFRPD--------PE--
-GSWK--HG-N-F-SCKR-V----------------------P-FR-C-------K-EDV
---LSNN--K-QA---QQCQGGA--A---LKP--------EYVS---FC-----------
----------ALINATLLVLDDVCGNETTA--VYLEVKINTANSLAAVLE---RTSALS-
EVSKEKTSALGTAILESVESAM-LA--RL--PSA------SITPQLHLGSSDIESRVMGE
ECTGQSTAFR-LR------A-----------------KGD---------EMKV---GCST
IKESA-------SPG-----TVGVAFVSFAGL-----ESVL-DERFSQDL--------QS
PLANPRTR---------------LK--INSRV-IGGVMTGE---KKEN-FLEP-VVYT--
-----L-ENT---Q---------------P-KQ-ESES

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSA---AGG-RWTA
S-GCAVQ-EASA-THTV-CSCRH-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYVISHVGMLMSLVCLILAIATFLLCRSIQNR-NTYFHLNLSVCLF
LAEILFL-VGIDKTDN----------QMSCT---IIAGALHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNVKTLYLCAFSYGLPALVVVVSASVHPRGYGMHD---R-CWLDT-
-K------RGFIWSFLGP----VCTIIT--------------------------------
-----VNSVLLTWTLCIL-RQKLSSVNAEVST-L--KDT--RLLTFKAFAQLFVLG--CT
WVL-GVFQ-IGP----LAGVMAYLFTIINSLQGAFIFLIHCLLSRQVRE--EYRRWITRK
AKPSS-QSQSSGI-------LLSSVPTSSKTVRDR-VRP--AGAGVLAAQRPSVLPGVEC
PRGAG--CA----HLSRFMQ----------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----QLKPRDCK--SHGICINSQGSYTCKGSLT--------------SPEGPT-T--E-
Q

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVNECTSGQNPCHTST--------HCLNNI---GGYECRCRPGWKPVSGSPNGPNNTVC
EGAELRRHILH----------------TLSHLMNGVLPPAEMS-FPTWT-PPPGIQSQ--
-------------------------------------------------SMSHFFEK---
----------------VQDLRRDFK--PALAQRTIQAT--LLPAWDELLE---TPEDLE-
DLPPSEQHCVATNLLVGLE-DV-LRNISQALPNGT-PTF---------------------
-KAPAGTDLA-LV--VQE-Q-----------------GHTNVTLSSNQAKM-L---LNWN
VVHET----DD--SG-----PSVAGLISMPGM-----GKLL-AEAPMVLE----------
--PEKQPVLH----GAQKGVLQGVPSVLLSDV-ISAFTSNR---DTEN-LSSL-ITFI--
-----F-SHRS-AT-----------------LG-PK

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEHS-QDGCGHWST
T-GCRMV-ATRD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2142)

-PL---
--------------LAAITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDRTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSA-SRVMKKLMFPVGYGAPAIIVALSAASRPHLYGTLT---R-CWFHP-
-E------KGFLWSFLGP----VCVIFS--------------------------------
-----VNLAFVLMTLWIL-KSKLSSLNSDVST-L--QNT--R------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGKLVLNSWS--QGIYPPWPPEV--------LGLQVY

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 435)

NKCRDSTMCPSHATCTSTVDS
YYCA-CKQGFRSSNGQ--NHFKDPGVECKGEFISPQ------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
T--LQHLVVKSSKSGRPELAV-------------------------------E-PRSCPT
WH------------------------YSL---GN------R-------------------
--VRLH-------------PRSKKA---------KK---NN

PF07645 // ENSGT00900000140800_1_Domain_10 (822, 855)

IDECTEMCPINSTCTNTPG
S-YFCTCHPGFAPSNGQLN-FTD--QK--VECR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1324)

DTDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPD--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQERT--T---VKP--------EYVS---FC-----------
----------AQMNNIFSVLDNVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESLT-LA--AFLKPSA------NVTQTVRTDYLGRRYPSYQQ
RMRGRRFEVH-LS------LSLVCVCECVCVCVCVCVRSS---------IITIEQTIPSF
FHLGK-------PAG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2069)

-LYVISHVGMIISLVCLVLAIATFLLCHSIRNH-ITYLHLHLCVCLL
LAQILFL-AGIDKTDN----------QTGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RDIKMLHICAFGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIAVSKYDNSLAKCVLEEEQGDLRDLEFP----GT
CAAERINSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTVINSLQGAFIFLIHCLLNRQVRE--EYKRWITGK
MKPSS-QSQTSSI-------LLSSMPSTSKTVRDC-MLP--AGAGQGRCRPLGDTQLCHV
LGTEW--ELRVLTLVSSWM-KCGVED--WGFLCIYQQ---THTHYLSVY---HLSIYHLS
IDLSSIYLSSVIYLS----SIIYLSSIIHLSIIYHLSSMYLSSIYHLSSIYHLSIIYLSS
IYLSSIYHPSIIYQFK

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------FCPPCPENADCYN
S-THCTCKGGFQSTSGRRY-F-K-PN-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1170)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QTG-LAKCQQEAYCRN-QIGSYYCSC-------VPNF-PIF-------------
-----NWV------AGI---------------------------------IKLNH-----
---------------------------ENCYEDA----------GEK-PL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------LS--GNVWXXXXX-------------------
XXSKKHIAKAT---L-SQIEL-IWN-KSFVS---P-GKHENATLD-----IVYETKRCNE
----TSEKTI-

PF00002 // ENSGT00900000140800_1_Domain_22 (1572, 2189)

LE------A-----------------GNN---------TMNI---DCSA
SFKGA-------TRD-----RNVVALSLTGLL-----GIXX-XXXXXXX--------XXX
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------XXXXXXX
XXXXXXX-XXXXXXXX-------E---VLCS---VIAGVLHYLYLASFTWMLLEGLHLFL
TVRNLKVANYTNA-GRFKKRFMYLFGYGLPALIVAVSAIVGHKNYGTY---TH-CWLKL-
-D------KGFIWSFMGP----VALIIL--------------------------------
-----INLVFYFQVLWIL-RSKLSSLNKEVST-I--QDT--RMLTFKAIAQLFILG--CS
WGH-GFFL-VEEILDLIRVI--YSFTIIVLQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MGPT---AQN--S-KACALWCPPNSSCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTACRCAPGFISFSGEI-F-------------------------------T--DPLESCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECGPPS-PVDCGSSANCQN-TEGGYYCTC-------SPGYEPVSGP--AVFRNESEN
TCRDVDECQH-------------------------------------------------R
PRVCKGRSICINTEGSY-TCQCPPGLEFN----P--EDP-----RHC-TDVN-ECTSGRK
P----------CH--SSTHCLNSVGSYECRCR----PGW--KPIPGSPNGPSNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1311)

DADECSSGQHRCHNST--------VCVNTV---GSYTCHCRQGWVPRPGFQDKQKNTIC
E---------------------------------------EIS-FPIWT-APSEIKSQA-
--------------------------------------------------LSHFFNR---
----------------IQDLRRNFS--SVSVLNTVRD---LVQEMGDLLE---TPRDLK-
TLPFSEQRFVVTNLLFGLE-NV-LRGVSKALPKGS-FNF---------------------
-SSSAGIELS-LE--VQA-P-----------------SYRNITLIQNQTKM-M---LTWD
TVHDS----GD--SG-----LAVVGLLSTPGM-----DRFL-AEAPLVLD----------
--AEEPTTLR----ETHRGLLQETSHILLSDV-ISAFITNK---DTES-LRSP-VTFV--
-----F-QH------------------SVT-PG-PREKVH

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WEHG-QNGSGHWDT
R-GCWVA-STRD-NST-TCQCTH-LS----IF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--YGV--QEED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLFFL-TAFDRTEN-------K---VLCA---IIAGALHYLYLASFTWMLLVGLHLFL
SARNLTVVNYSSI-NRFMKKAMFPVGYGVPAVIVAISAASRPHLYGTPT---S-CWLHS-
-E------EGFKWGFLGP----VCAIFS--------------------------------
-----VNLAFFLMTLWIL-KSKLCSLNSEVST-L--QNT--RMLTFKATAQLFILG--CT
WFL-GLLQ-VGP----AAHVMAYLFTIINSLQGVFIFLVYCLLSKQVRE--QYRKWLERI
RKSKA-KSEKYTL-------SS-RTMSDD--CKHSEETYING------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MTRHEQPRWSSSSLD

PF07645 // ENSGT00900000140800_1_Domain_1 (399, 431)

GNGCTDTTMCPAYATCTNTSRS
YYCS-CKRGF

ENSGT00900000140800_1_Linker_1_3 (431, 450)

LSSNGL--KTFKGPGVECK

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 488)

DIDECSQSPTPCGPNSICRNLPGRYRCSC--
MTGFSSP

ENSGT00900000140800_1_Linker_3_5 (488, 506)

TGNNWISG--KQGHFTCR

PF07645 // ENSGT00900000140800_1_Domain_5 (506, 538)

DINECLSHGVCPEHSECTNSLGSYCCSCQVGFTL-
------------------------------------------------------------
----------------------------------------------KNAICAN

PF07645 // ENSGT00900000140800_1_Domain_6 (654, 686)

IDECSQK
PPPCGPNSRCRNLPGRYECSCLTGFSSPTG--NNWISGKPGHFTCTDINECLS-HGVCPE
HS------------------------ECT---NSLGSYRCS-------------------
--CKVG-------------FTSGNS---------TCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 854)

DVDECANPRSCPEHSTCHNSLG
S-YSCVCNPGFQS

ENSGT00900000140800_1_Linker_10_11 (854, 872)

RSGRKS-FQG--PGEMCQ

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DIDECSQ---KP-PPCGPNSRCRNLPGRY
ECSCLTGFSSPTGNNWISGKPGHFTCT-DI--------NECLSH--GVCPEHSECTNSLG
SYRCSCKVGFT------------------------------------------SGNSTCE
DVDECA--N-PRSCPEHSTCHN-SLGSYSCVC-------NPGFQSRSGK--KSFQGPG--
-----------------------------------------------EMCQDIDECSQT-
PPTCGPNSSCRNLPGRY-ECSCLTGFSSPTG-NN--WIPGKSGHFTC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1244)

DIN-ECLS-HG
V----------CP--EHSECTNSLRSFCCSCD----VGF--TS

ENSGT00900000140800_1_Linker_15_17 (1244, 1263)

KN-----------SIC-
EN

PF07645 // ENSGT00900000140800_1_Domain_17 (1263, 1322)

IDECLQDPSRCGPDS--------VCTNTL---GSYSCGCVVGFHPN--------PE--
-GSWK--HG-N-F-SCQR-I----------------------P-FK-C-------K-DDV
---IPSN--M-QV---QLCHAGA--A---VEP--------KYVS---FC-----------
----------ALMNATLSVLDNVCENKTTV--VSLK---STAKRLDSVIE---KTSKWS-
NFTKEETSTLATVLLESVESTT-LA--AFLKPSA------NVSQTIQTKHLDIESKVIDK
ECTKENETFK-LK------A-----------------KGD---------EMKI---WCST
IKESE-------STG-----INGVAFVSFSGM-----ESIL-DERFLKDL--------QI
PWASSKKK---------------LK--MNSRV-VGGIITGG---KKDG-FSKP-VIYT--
-----L-ENI---K---------------P-KQ-DFESAI-CVS--WKPD-VEGG-RWTP
S-GCVLL-EASK-THTV-CGCNQ-MV----NL-AVI-MA-S--GE--VTME----FT---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYLISHVGTIISLVCLAMAIITFLLCRTLRNQ-NTYIHLHLCICLF
LAKMLFL-TGVDKTDN----------QMGCA---LIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYN---R-CWLNT-
-E------TGFIWSFLGP----VCTIIV--------------------------------
-----VNSILLTWTLCIL-RQKLSSVNAEVST-L--KDT--RLLTFKAFAQIFILG--CS
WVL-GIFQ-IGP----MANIMAYLFTIINSLQGAFIFLIHCVLSRQVRE--EYRRCTTRK
TKPSS-ETQTSGI-------LLSSVPSTSKTV----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MGS----------WYLI---LLSGVSVL-------------------
-----------------LVL-----------PS-LEV-----KNFGAFCPPCPKNADCHN
H-THCVCHSGFQSMSGRKY-FME-SY-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------NSG-LKNCKKDAYCTN-TDGSFYCSC-------FIKY-PQF-------------
-----NWV------ANL---------------------------------IGLRP-----
---------------------------PGCYENT----------SEE-TP-S--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------SSS--GNIWENLMING---------------S-
Q---KELAINITKILQQVELT-IWK-ENFNS---T-GIHENSELD-----IVYETKRCNE
----TSKKTF-LA------A-----------------GNN---------TMDI---NCNH
IFKGP-------TRD-----QNAVAFITYRSL-----GNIL-NGSFFSE--------RRG
-----RQG-----------------VKLNSHI-VSGTIGSE---KKVN-LSEP-VSLT--
-----F-QHTE------------------P-GG-ARTE

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

YF-CVY--WEGS--KEGGSWST
G-GCNYK-SSND-SYT-KCECFH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MSL----S--PKAD----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITYVGLSLSLLCLLLAALTFLLCQPIQNT-STSLHLQLSLCLF
MAHLLFL-TGIDRTEP-------A---VLCS---IIAGALHYLYLAAFSWMLLEGLHLFL
TVRNLQVANYTSA-SRFKKRFMYPLGYGIPALIVAVSAIIGYKNYGTR---TH-CWLKL-
-E------KGFIWSFMGP----VAVIIL--------------------------------
-----INLVFYVIILWIL-KSKLSSLNKEVST-I--QDT--RVMTFKAIAQLFILG--CS
WGL-GFFM-VEEVWKTVGLVIAYAFTIINVLQGVLLFVVYCLLNRQVQM--EYKKWFSGK
QKGVG-TE-SSEL-------SR-STTHTK-MEEPV-KSS-ELFHKGDTASPL-----PQP
--T--------QFVSISWVKM--D------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------IPGLCFLLS-FFGA----VIPKIK---GECSECGPRAGPG----
------------------------------------------------------------
-----------------------------------------------------------S
-----------TFLQWKLF-------------------------------T--FPLETCN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1075)

DINECGPPY-SVYCGSNAACHN-VEGSFYCRC-------APGYRLQSGE--ERFSNSSEN
TCQDTNSSKTTQGKKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDTF----------------------------ESLLTNQ-TLWRTE------------
--------------------------------------------------GRQEISST-A
TTILRDV--E------S----------------------------KV-------L-----
----------------ETAL-------KAP-EQKVQ----------KI------------
----------QNS-SVAIETRVITD-------NCS-------------------------
---EERKTFN-LN--VQ-----------------------M-------NSMDI---HCND
VIQKD-------TQG-----TRDGCIQNPSHRAMSLSSGN--CHSTF-FE---------G
MV--TYS-----------------------------AALPM---HMSK-LIKM-------
-------YTFN------------------M-MP-QF-----------------------K
E-G-AII-PVQE-S-----------------V-TVN-SFS---RS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSLSLLCLLLAALTFLLCKTIQNT-STSLHLQLSLCLF
VAHLLFL-VGIDQTES-------K---VLCA---IIAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASRPHLYGTAD---R-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLIFFILVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GFLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREI
VKSKS-ESETYTL-------SS-KMGPDS-KPSEGDV-----FP----------------
-----------GQVKRK-------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MGGRVFL

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECVPPS-KVSCGKSSDCRN-TEGSYDCVC-------NPGYELVSGA--KTFKNESEN
TCQ---------------------------------------------------------
---CKSYGTCVNTLGSF-TCQCLPGFKFK----P--EDP-----KLC-TE----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------FS-LE--VQK-Q-----------------VDRNVTLRQNQATM-Q---LHWN
LAQKS----GD--P----------------GM-----GKLL-AEVPLVSE----------
--PENQVVRN----ETHQGLL----PILLSDV-ISAFLSNN---DTQN-LSSP-VTFT--
-----F-SHRS--------------------VI-PRQKVL

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVF--WEHG-QNGCGHWAT
T-GCSTM-GTRD-TST-ICRCTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAP--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSLSLLCLLLAALTFLLCKAIQNI-STSLHLQLSLCLL
LAHLLFL-VAIDRTEH-------E---VLCA---IIASALHYLYLAAFTWMLLEALYLFL
TARNLMVVNYSSI-NRFTKKLMFPVGYGVPAVTVAISAASRPHLYGTPS---R-CWLQP-
-E------KGFIWGFLGP----VCAIFS--------------------------------
-----VNLALLLVTLWIL-KNRLSSLNNEVST-L--QNT--RMLAFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWSKGF
RKLRT-ESEMHTL-------SS-SAKADT--PKPSTPGTVAQ-A----------------
-----------CNASTL------GGRGGQI------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------CAQWCPQHSTCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATSCCCAPGFISF-GEI-I-------------------------------T--NLLEICE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECKTPT-TVSCGKFTACQN-TEGSYHCMC-------SPGYVLVSGK--TTFRNESEN
TCQG--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------IS-FPTWT-SRPGINSK--
-------------------------------------------------GFSHFLRK---
----------------INDLGRDYN--SASTLDTIQG---IIQVVDDLLE---NSEDLE-
TQPSSEQNCVASNLLLIVE-HV-LRKLSTALSNES-LTF---------------------
-TTAGGTEIS-VK--VME-Q-----------------GQRNITLSVNQAKM-L---LNLD
AVQES----GD--SG-----PSVVSLVSTPGI-----GKLM-AEAPLVLD----------
--TEEQAVLH----ETHKGLLHEVSPILLSDV-VSVVVSNN---DTLN-LSSS-

PF01825 // ENSGT00900000140800_1_Domain_21 (1735, 1838)

VTFI--
-----F-QH-------------------------------------WEHG-QNRSGYWST
K-GCWVV-DTGD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QVED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVFTYMGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-MAIDRTEI-------K---VLCA---IIAGTLHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSV-SRFMKKFMFPVGYGVPAVIVAISAASRPHLYGTST---R-CWLHT-
-Q------KGFIWTFLGP----VCIIFS--------------------------------
-----INLAFFLMTFWIL-KIKLSSLNSDVST-L--QNT--RMLTFKVTAQLFILG--CT
WCL-GILQ-VGP----TAHAMAYLFTIINSLQGVFIFLVYCLLSQQVRK--QYRKWLKEV
KKTKD-KSGRYTL-------SS-MIMSEA--SNPSM------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------G--DPY------A------------------
------------------------------------------------------------
--G----PVCQAQALCV-LL---IL-LEDGPQSTRASA---C---PRRCPANSKCL----
------------------------------------------------------------
-----------------------------------------------------------N
GTACRCDPGFKSSSGEI-D-------------------------------I--SYKDLCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECEQGKLETLCGREADCHN-TKGSYYCTC-------IPGYRLVSGA--AKFSDASEN
TCQGIDER-HL------------------------------------------------N
PRICKSCSNCVNTHGCY-TCTCLAGFEHN----L--QDL-----NLW-KDVNEC-STHKE
Q----------CH--KMTHCHNTEGSYECRSR----QSW--NLIPGSPNGPHNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVDDCKPGQNSCHKST--------QCHNTE---GSYECRCRPGWKPVPGSPNGPHNTVC
EEE--------------------------------------IS-FPTWT-PPPGIKSQ--
-------------------------------------------------SLSRFFEK---
----------------VQDLRQDFK--SASAQDTIQD---IIQEVDNLLE---NPGDLL-
TLPPSEQHFVATNLLTGRE-HI-LREMSKALPNGP-LTF-------------------R-
-TA-AGTELS-LD--VKK-Q-----------------GDKNITLSINQAKM-L---VNWD
VVQDS----GG--SG-----PAVVGLVSSPGM-----CKLL-VGAPLVLE----------
--TE----------ETHKGLQQEVSPVLLSDV-ISAFVSNK---DTQN-LSSP-VTFV--
-----F-KH------------------SVT-PR-PK

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEPG-QNGSGHWST
K-GCWRV-GTGD-TST-ACQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TTRNLTVVNYSNV-SRFMKKFMLPVGYGVPAVIVAISAASRPHLYGTPA---R-CWLHP-
-E------KGFIWGFLGP----VCVILF--------------------------------
-----VNLAFFLMTLWIL-KSKLSSLNSDVST-L--KNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAHAMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKCWKRV
RKIKA-ESEQYTL-------SS-GAMSDA--TKHSVVRPCIP-P----------------
-----------R------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHTGPTLKPT------------TKDNKCRDSTMCPSHATCTSTVD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCA-CKQGFRSSNGQ--NHFKDPGVECKDVDECSE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SQPCGPNSVCKNLSGRYECSCLRGFSSPTG--NNWKPGKPGNFSCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 801)

DINECLT-GRVCPE
HS------------------------DCV---SSMGSYNCN-------------------
--CQVG-------------F

ENSGT00900000140800_1_Linker_9_10 (801, 821)

ISRNS---------IY---D

PF07645 // ENSGT00900000140800_1_Domain_10 (821, 853)

NECANPRMCPEHATCNNTVG
N-YSCFCDPGFESSSGHLS-FQG--LK--CEGRWGCRL---RN-QVQDSFAPA-----TL
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------F--DGQSKRH--
-----------------------------------------------FFLA---------
------------------------------------------------------------
------------------------------------------------------------
-DIDMPPKIHQTCGPNS--------LCTL-----WALQRGSFAGFRPN--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQERT--T---VKR--------EYVS---FC-----------
----------AQINNIFSVLDNVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVLLESVESLT-LA--AFLKPSA------NVTQTVRTDYLDIESKVINK
ECSEENVN-----------LSLAAK-------------GD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1875)

I-MA-S--GE--LTMD----FY---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LYVISHVGMIISLVCLVLAIATFLLCRSIRNH-ITYLHLHLCVCLL
LAKILFL-AGIDKTDN----------QTGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIA--------------------------------
-----INSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GILQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNHQVRE--EYKRWITGK
MKPSS-QSQTSSI-------LLSSMPSTSKTVRDC-MLP--AGAGQGRCRPLGDTQLCHV
LGTEW--ELRVLTLVSSWM-KCGVED--WGFLCIYQQ---THTHYLSVY---HLSIYHLS
IDLSSIYLSSVIYLSIYHLSIIYLSSIIHLSIIYHLCIYHLSIIYHL-AIYHLSIIPLSS
IDLNKISRIRHI----

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------G-----TVAVAFIVYKNL-----EDVL-NNVT--------------
----KVSP-----------------GALISHV-VGGTVGND---KKTT-FSSD-FFIT--
-----L-QHNE------------------S-LQ-EG

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

KEAV-CVS--WKPD--DSKGQWTP
E-GCRRT-GGNN-WSS-ICACNH-FS----SF-AIT-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAT---RE--GNES---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2152)

-HA---
--------------LWVVSCVGLSVSLLCLFLTIVTFVLCRSLWSV-SISLHLQLSICLF
IADLLFL-VAEHLTTK-------K---LLCK---IIAGCLHYFFLASFSWMLLEGLHLFL
TVRNLRVLNYLSA-TRFKRRYIYPVGYGLPAIVVAASAATRPDGYGAE---KH-CWLNT-
-E------GGFIWSFVGP----VCVIIL--------------------------------
-----INLIFFLITLWTL-RKRLASLNADVTA-I--KNT--RLMTFKALAHVCI------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------Q-EIGDSY-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LNFTNLTSQL---------------T-
AGKPKEKAVLVTLYLQNMEKA-VLA-AAVRNTKER-QNVEGPFMD-------IETRRVEK
C--SLMKTFR-LK------A-----------------GNQ---------TMDI---LCTT
IQKES-------LGG-I---PGAVAFISYASI-----GSII-NESFVSE--------ENL
MTKEKLHN-----------------FYLNSKV-VSGTMGSR---KNTS-LSTS-INFT--
-----F-QHEK------------------I-KR-ENE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

QPL-CVY--WQ------GSSWSN
E-GCQVI-SSDE-NQT-VCSCSH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAS---TK--TQVD----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTMITYVGLSLSLLCLFLAALTFLLCRPIQNA-STSLHLQLSICLF
LAHLLFL-SGINRTEP-------K---VLCS---IIAGVLHYLYLAAFTWMLLEGLHLFL
TVRNLKVANYTSA-GKFKKKFMYPFGYGIPALVVAVSAVIGPQNYGTH---TH-CWLKL-
-D------RAFIWSFMGP----VAVIIL--------------------------------
-----INLLLYFQILWIL-RSKLSSLNHEVST-I--QDT--RVMTLKAIAQLFILG--CS
WGL-GFFT-FEELGKVIRLVMAYTFTIINVLQGILLFVVHCLLNRQV-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------VGGHL---AIPGLCFLLS-FFGA----VIPKIK---VSC-NCPPNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NGHCTCNSGYISGSGQKLF-------------------------------T--FPLETCN
DINECEPPY-SVYCGSNAACHN-VEGSFYCRC-------VPGYRLQSGE--ERFSYSSEN
TCQDTNSS

PF12003 // ENSGT00900000140800_1_Domain_16 (1089, 1718)

KTTQGKKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDTF----------------------------ESLLTNQ-TLWQTE------------
--------------------------------------------------GRQEISST-A
TTILRDV--E------S----------------------------KV-------L-----
----------------ETAL-------KAP-EQKVQ----------KI------------
----------QNS-SVAIETRVITD-------NCS-------------------------
---EERKTFN-LN--LQ-----------------------M-------NSMDI---HCND
VIQKD-------TQG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
TD--EKDRVF-----------------LNSQV-VSAA

ENSGT00900000140800_1_Linker_16_21 (1718, 1778)

IGPK---RNVS-LSKS-VTLT--
-----F-QHVK------------------M-NR-SIK

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KAF-CVY--WETT--KQGGLWSR
D-GCFLI-HVNK-SHT-MCNCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAL---TS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
VAHLLFL-VGIDQTES-------E---VLCA---IIAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASRPHLYGTAD---R-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLVFFILVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GFLQ-VGS----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREV
VKSKS-ESETYTL-------SS-KMGPDS-KPSEVSEH----FR----------------
-----------GYTYRMC------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFKLL--------------
LFWGCCVMDIWE--MHTGPTLKSTI-----------KNA

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NKCRETTMCPAYATCTSNMDS
YYCT-CKRGFLSS

ENSGT00900000140800_1_Linker_1_4 (434, 450)

NGQ--RRFKGPGVECK

PF07645 // ENSGT00900000140800_1_Domain_4 (450, 816)

DI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------NECLT-NGICPE
HS------------------------DCV---NVMGSYFCS-------------------
--CQIG-------------FISRNS---------T

ENSGT00900000140800_1_Linker_4_10 (816, 819)

CE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DVDECLNPRACPEHATCHNTVG
A-YTCLCNPGFESSSGLLS-FQG--LRELC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECI-----EMCPINSTCTN-TPGSYFCTC-------HPGFAPSNGQ--LNFTDQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECLQDPSTCGPNS--------VCTNVL---GSYNCGCIAGFRPN--------SE--
-GSQK--DG-N-F-SCQR-L----------------------P-FK-C-------K-EDM
---IPNN--E-QA---QQCQEGT--T---MKP--------EYVS---FC-----------
----------ALINDMFDILDNVCENKRTA--VSMK---VMIESFKLCFE---FQISWA-
HTGCRKTSLWPGV---------------------------VAHTGNSSTLEDIESKVIDK
ECSEENVTLS-LA------A-----------------KRD---------KMKI---GCST
IEASE-------SRG-----TTGVAFVSFVGV-----ESVL-DKRFFHNP--------QT
PLANSEVK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WRTD-VEGG-RWTP
S-GCVVL-EASE-VHTI-CSCNH-LA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2069)

-LYIISHMGIIISLVCLILAIATFLLCRSIQNH-NTYLHLHLCVCLL
LAETVFL-AGIDKTDN----------QMGCA---IIAGFLHYFFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMPYLCVFGYGLPGLVVVISASVQPQGYGMYN---R-CWLNT-
-E------AGFIWSFLGP----VCIVIMVSKYYDSLVKRVLEEEQGDFS----P----SC
CLTLQINSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GLFQ-FGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNHQVRE--EYKRWIPGK
TKPSS-ESQTSRI-------SLSSMPSTSKTVRDC-MLP--VGTGQGRCQPPTDSQLCHV
LGTEW--ELRVPTLGSSWI-KYAVKD--WGVIYILAD---THIIYLNIY---HLSI----
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------QCPACPQNARCHN
S-THCACDEGFQPR------FVK-FY-ERCEDIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QTG-AARCKPVAFCRN-RIGRYICSC-------VVNASFWV-------------
-----NLL------ASF---------------------------------ITVDH-----
---------------------------PDCYKDR----------NQK-ME----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SP--GDVWVNLRR-------------------
NTSKQEFARNATQMLQQVELA-IWN-ASLTS---P-HKGANPLFG-----IVYESKKCHE
----ASEHIL-LE------A-----------------GNN---------TMLI---SCSG
AFQTT-------GGR------N

PF00002 // ENSGT00900000140800_1_Domain_22 (1643, 2207)

AVALS---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LTSLWGMLAIRST-GTSIHLQLTLCLF
LAHFLFL-TGIQRTES-------Q---VLCS---IVAAALHFLYLAAFVWMLLEGLRLFL
TVRNLQVANYTSA-SRFKKRFMYPLGYGVPAVIVIVCASVGYENYGTY---TH-CWLSP-
-D------NGFIWSFLGP----VAAIIL--------------------------------
-----INLVFYFQILWIL-RSKLSSLNKEVST-I--QDT--RLMTFKAIAQLFVLG--CS
WGL-GYFM-VEEMGETVGSVMAYLFTIVNVLQGLLLFVMHCLLDRQVRS--LVPSK----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
VIPGT-----STAMGS----------RCL----LLLSGPMV-------------------
-----------------IFL-----------LY-VSK-----MHSQVSCPPCPENANCLS
G--TCVCKDGFQSVSQKWF--LK-SV-QKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------AKG-LAKCKQKAYCRN-GIGNYYCSC-------VPHY-PLF-------------
-----NWV------ASI---------------------------------LTINH-----
---------------------------AECYEDA----------NNE-TQ----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------VP--GDVWKILRNNG---------------S-
K---NSIAKQVTQLLQRVELT-IWN-QSFVS---P-GKHEDSVLD-----IVYETKKCNE
----TSEKTV-LE------A-----------------GNN---------TMDI---DCPN
AFKGT-------TRD-H---RSAVALITYRSL-----GSVI-NGSFFSD--------RRG
-----IKE-----------------VNLNSQV-ISGSIGVK---EKVD-LSKP-VFLT--
-----F-QHTQ------------------P-GG-GRRK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

YF-CVY--WKGS--KDGGGWST
E-GCSHL-GSND-SHT-QCKCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

VAL----A--PKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2194)

-LTMITYVGLSLSLLCLLLAALTFLLCRSIQNT-STTLHLQLSICLF
LAHLLFL-VGIDQTEP-------E---VLCK---VIAGVLHYLYLAAFTWMFLEGLHLFL
TVRNLKVANYTTA-GRFKKRFMYPVGYGVPALIVAVSATVGHKNYGTY---TH-CWLKL-
-D------KGFIWSFMGP----VALIIL--------------------------------
-----INLVFYFQVLWIL-RSKLSSLNKEVST-I--QNT--RVMTFKAISQLFILG--CS
WGL-GFFL-VEEVGETIGSIIAYMFTIINVLQGTLLFVVHCLLNHQVQM--EFKKWFSGV
RKGVE-TE-SSEV-------FR-SATQTK-MEKLE-KSS-EFFCKRDSAS-I-----QPP
PGP--------HVVGISWFKTDN-------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------GSS------M------------------
------------------------------------------------------------
--F----PELLLTALCV-LL---TL-LEDGPQNTRASA---C---PQQCPPDSSCV----
------------------------------------------------------------
-----------------------------------------------------------S
GTACRCDPGFLSPSGKN-E-------------------------------V--NQGETCE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECEQP-VKVTCGKDARCHN-TKGSYYCTC-------KPGYRPGSGA--TKFSNASEN
TCQGMDKR-QL------------------------------------------------N
PVICKSHRNCVNTHGSY-TCQ--AEFELN----P--QDP-----KLC-KEGDLVQQSGRQ
P----------CH--KMTHCQNIVSSYECRCR----PNW--KLIPGSPNGPHNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVDDCQPGQNSCHKST--------QCHNTE---GSYDCLCRPGWKPVPGSPNGPHNTVC
EQD--------------------------------------IS-FPTWI-PPPGIKSQ--
-------------------------------------------------SLSHFFEK---
----------------VQDLHRDFK--AALAQDTIQD---IIQEVDNLLE---TPGDLF-
TLPRSEQYCVATNLLTGWE-HI-LRELSKALSNGT-LTF-------------------R-
-TA-AGTELS-LE--VKK-Q-----------------GDKNVTLSINQAKM-L---VNWD
MVQDS----GG--SG-----PAVVGLVSSPGM-----GKLL-VGAPLVLE----------
--TEEQSVLN----ETHKGLLQEVSSVLLSDV-ISAFVSNT---DTQN-LSSP-VTFV--
-----F-KH------------------TVT-PG-PR

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEPG-QNGSGHWST
K-GCWMV-GTGD-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TTRNLTVVNYSSV-SRFMKKLMLPVGYGVPAVIVAISAASRPHLYGTPA---R-CWLHP-
-E------KGFIWGFLGP----VCAILF--------------------------------
-----VNLALFLMTLWIL-KSKLSSLNSDVST-L--KNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAQAMAYLFTIINSLQGVFIFLVYCLLSQQVQE--QYRKWWKGV
RKTKA-ESEQYTL-------SS-GIQSDA--PKHSVVRPCIA-P----------------
-----------R------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------FC--S-FVNSTLV
NLET---IC--AQNTTV-----SLEEVAIP--FGSLLNS-SAL---------------S-
AGESKNVRSAVMLLLQSVELA-VLD-AALKSPKMKRQNVTTESMAISTLLIDTNADSCDK
-------GFR-LR------A-----------------QED---------AMDI---DCNT
VTEGG-------SQN-----STAIAFISYSTL-----DVII-NKGIFEE--------GDL
-----MDH-----------------KKLNSRV-VSGAIRAG---RHMN-FSKP-VNIT--
-----L-RHRQ------------------V-KK-EEEKVH

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVH--LKAI--TGKDIWAH
N-DCTVV-HMNN-THT-VCSCNH-LS----SF-AL

ENSGT00900000140800_1_Linker_21_22 (1836, 1875)

L-IGP---MG--VEDS----LP---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LTIITYVGLTLSLLCLLLAILTFVLCRSIRNV-STSIHLQLCLCLF
LADLLFL-TFVTHTSN-------Q---VACA---VTAGLLHYLFLACFTWMFLEGLHLFL
TVRNLKVVNYTSA-SRFKKRYMYPFGYGFPALIVAISAAVNSDGYGST---KH-CWLNL-
-E------KGFHWSFLGP----VCAIIL--------------------------------
-----INLTFFIVILWIL-RDKLSSLNEDVST-L--KDT--RVLTFKAVAQVFILG--CT
WSL-GLLQ-IGS----AKMVMAYLFTIVNSLQGVFIFLVHCLLNRQVRE--EYRRWITST
RKPSP-TT-QTFS--------L-STPAVS-------------------------------
--S--------SPKMVSWEDPVSTLSS---------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MGS----------RCLP---LLSGFSVL-------------------
-----------------LAL-----------LG-SEA-----KNSGALCPPCPENASCFN
S-IHCTCKDGFQSESGKKY-IIG-PY-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1170)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KTG-LAKCKQVSYCRN-EIGSYYCSC-------IPHL-PIL-------------
-----NWV------ASF---------------------------------VKLNH-----
---------------------------SECYENS----------SKE-TE----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------LS--QVIQTILKNN------------------
-GSKENIAKKATQLLQDIEST-IWN-RSFAS---P-GKFENSLLD-----IVYEIKKCNE
----TSEKTV-LE------A-----------------GNN---------TMDL---DCND

PF00002 // ENSGT00900000140800_1_Domain_22 (1621, 2207)

VFKGT-------TGE-----RSAVALS---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------L-----------------ISVLGILPIQNT-NTSLHLQLSICLF
LAHLLFL-TAIDQTEP-------E---VLCS---IIAGVLHYLYLASFTWMFLEGLYLFL
TVRNLKVANYTNT-GRFKKRFTYTLGYGIPALIVAVSAIVGHRNYGTY---TH-CWLSL-
-D------KGFIWSFMGP----VAIIIL--------------------------------
-----INLVFYFQILWIL-RSKLSSLNKEVST-I--QDT--RVMTFKAIAQLFTLG--CS
WGL-GFFM-VNEVGKTIGLIIAYMFTIINVLQGVLLFVVHCLLNRQVKL--IILSKPY--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------GCAPWCPRNSVCI----
------------------------------------------------------------
-----------------------------------------------------------N
AIACRCHPGFSSWSGEI-I-------------------------------T--SPVDSCD
DINECEPP-LAVSCGKFADCQN-VDGSHYCTC-------SPGYGLVSGA--TTFRNESEN
TCQDVDECQQ-------------------------------------------------K
PRICKGHSVCINTLGSY-NCTCLLGLELN----L--KDL-----NLC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1259)

DVN-ECASGHN
P----------CH--SSTHCLNIVGGYKCRCH----PGW--KPVPGSPEGPDGT-V--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
A

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVDECSSRQHRCHNST--------ACINTV---GSYRCRCRRGWTPLPGFQDNQNTTVC
EE---------------------------------------MS-FPTWT-PPPGIQSQ--
-------------------------------------------------CLSGFFER---
----------------VQDLRRRFT--PASAQDTVQD---LIQSVDELLK---APGDLE-
TLALPDRHHTVTHLLSGLE-EV-LRTLAKAMPGAS-FTY---------------------
-QSPAGTELS-LV--IQE-Q-----------------GHGNVTLGQSHARM-L---LDWA
VAAGSA----G--SG-----PAVAGILSNPNM-----QKLL-ANASLELD----------
--PERQAKLE----ETHESPLYGVQWRLLSAV-NSVFLSNT---NTTK-LDPK-VTFA--
-----F-SHPVSPG----AGRAPQDTDVEK-PG-TRQE

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

LI-CAF--WKGA-DDGGGHWAT
S-GCWTL-GSWN-NST-TCQCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAH--YDV--Q--D----PM---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2195)

LAVITHVGLSLSLLCLLLAALTFLLCRAIQNT-STSLHLQLSLCLF
LAHLLFL-TAMDRTEI-------Q---VLCS---VIAGALHYLYLASFTWMLLAGLHLFL
TARNLTVVNYSS-------KLMFPVGYGVPAVIVAISAASRPDLYGTPT---R-CWLRS-
-E------SGFIWGFLGP----VCAIFS--------------------------------
-----VNLAFFLMTLWIL-KSRLSLLNSDVST-L--QNT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AAHVMAYFFTIINSLQGVSIFLVYCLLSQQVRE--QYGKW----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RRTGPTLKPA------------TKD

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 435)

NNCRDSTMCPSHATCTSTVDS
YYCA-CKQGFRSSNGQ--NHFKDPGVECKDEDECAD------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PRTCPEHATCNNTVGNYSCFCNPGFESSSG--HLSFQGL--KVSCE

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 855)

DIDECT--------
------------------------------------------------------------
----------------------------------------------EMCPINSTCTNIPG
S-YFCTCHPGFAPSNGQLN-FTD--QK--VECR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1323)

DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPN--------PE--
-GSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQERT--T---VKP--------EHVS---FC-----------
----------AQINNIFSVLDNVCENKTTV--VSLK---NTTENFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESTT-LA--VFLKPSA------NVTQTVRTDYVDIESKVINR
ECSEENVN-----------LNLAAK-------------GD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGM-----ESVL-NERFFQDH--------QA
PLTISKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AVI-MA-S--GE--LTMD----FS---
--------------LYVISHVGMIISLVCLVLAIATFLLCRSIRNH-ITYLHLHLCVCLL
LAKILFL-AGIDKTDN----------QTGCA---IVAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLVVVISASVQPQGYGMYN-----------
------------------------------------------------------------
-----

PF00002 // ENSGT00900000140800_1_Domain_22 (2106, 2196)

INSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNRQVQE--EYKRWITGK
MKPSS-QSQTSNI-------LLSSMPSASKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------FS-LE--VQK-Q-----------------VDRNVTLRQNQATM-Q---LDWS
LAQKS----GD--P----------------GM-----GKLL-AEAPLVSE----------
--PEKQVVLN----ETHQGLL----PILLSDV-ISAFLSNN---DTQN-LSSP-VTFT--
-----F-SHRS--------------------VI-PRRKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WERG-QNGCGHWAT
T-GCSTM-GTRD-TST-ICRCTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAP--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2022)

-LTVITYMGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLL
LAHLLFL-VAIDRTEH-------E---VLCA---IIAGALHYLYLAAFTWMLLEALYLFL
TARNLMVVNYSSI-NRFTKKLMFPVGYGVPAVIVAISAASRPHLYGTPS-----------
------------------------------------------------------------
-----VNLALLLVTLWIL-KNRLSSLNNEVST-L--QNT--RMLAFKATIQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWSKGF
RKLRT-ESEMHTL-------SS-SAKADT--PKPSTPGTVAQ-A----------------
-----------CNASTL------GGR----------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWGFWLL--------------
LFWGCSGVHRWG--MTTLPTLGQSLK-----------GVNECEDTTTCPAYATCTDTID

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCT-CKRGFKSSNGQ--TNFKGPGVVCEDIDECLQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SSPCGPNSVCKNLLGRAQCSCLSGYSPPMG--QSWILGSSDHFLCT

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 801)

DIDECLT-IGICPS
YS------------------------NCT---NTIGSYNCT-------------------
--CQPG-------------F

ENSGT00900000140800_1_Linker_9_10 (801, 819)

IWHNL---------VCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DDDECVKHNACPEHAACHNTLG
S-YHCTCDSGH

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ESSGGRSM-FQG--LEESCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 915)

DVDECSR---NS-TLCGPTLICINTQGSY
NCSCPSGFSLST--SQVPGHQAD-------------------------------------
--------------------------------------------------------KKCI
DIDE----C-DAICPSNSLCTN-TPGSYFCTC-------HPGFALSNGQ--VNFTDPE--
-----------------------------------------------VACE---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECIQDPSPCGRNS--------VCTNVP---GSYICGCLPNFRPE--------PE--
-GSQA--HG-N-F-SCKR-I----------------------P-FK-C-------K-EDL
---IPNS--E-QI---QQCQAGN--A---RDF--------DSAS---FC-----------
----------TLVNATFSILDNTCANKSAP--VSLQ---NAARSISQVLE---RAPQWA-
ELSREETSALGTILLETVESAM-LA--TLLTPSV------NVSQTIETENLDIESKVINE
DCNEENMPFN-LK------A-----------------RGD---------SMTV---GCSI
IKESE-------STG-----TPGVAFVSFAHM-----ASVL-DERFFEDG--------LA
SW-----K---------------LK--MNSRV-VGGIMTGE---KKEG-FSKT-VVYT--
-----L-QHI---Q---------------P-KQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WNPN-VDDG-RWTR
S-GCKIT-KASE-TYTE-CSCNR-MA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--ITME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGTVISLVCLALAIATFLLCRAVHNQ-NTYMHLHLCVCLF
LAKFLFL-VGVDKTDN----------QTACA---IIAGFLHYLFLACFFWMLVEAVMLFL
TVRNLKVVNYFSS-RNIKMLHLCAFGYGLPVLVVVISASIQPQGYGTHN---L-CWLNT-
-K------TGFIWSFLGP----VCGIIT--------------------------------
-----INSILLTWTLWVL-KQKLCSVSSDVSK-L--KDT--RLLTFKAIAQIFILG--CS
WVL-GIFQ-IGP----MASIMAYLFTIINSLQGAFIFLIHCLLNRQVRG--AYREVIIRK
TESSS-HSQTSGI-------LLTSMQSNSKMG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MGS----------RCLL---LLSGLSVL-------------------
-----------------LAL-----------SG-LEA-----KEAGVSCPPCPENANCLN
G--TCVCKDGFESVS-LWY--SR-SA-QKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------ARG-LAKCKKKAYCRN-GIGNYYCSC-------VPHY-PLF-------------
-----NWV------AGI---------------------------------FTINH-----
---------------------------AECYEDA----------SDK-TQ----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AP--GDIWEMLRNNG---------------S-
K---NYIAKQATQLLQHVELT-IWN-ESFVS---P-GKYENSALN-----IVYETKKCNE
----TSEKTV-LE------A-----------------GNN---------TMDI---DCPN
AFKGT-------TRD-----ASAVALITYRSL-----GDIL-NGSFFSD--------RRG
-----IKE-----------------VNLNSQV-ISGSIGMK---EKVD-LSKP-VFLT--
-----F-QHTQ------------------P-GG-ERRK

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

YF-CVY--WKGS--KDGGSWST
E-GCAHL-GSND-SHT-QCKCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

VAL----V--PKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2194)

-LTMITYVGLSLSLLCLLLAALTFLLCRSIQNT-STTLHLQLSICLF
LAHLLFL-VGIDQTEP-------E---VLCK---VIAGVLHYLYLAAFTWMFLEGLHLFL
TVRNLKVANYTTA-GRFKKRFMYPVGYGVPALIVAVSATVGHKNYGTY---TH-CWLKL-
-D------KGFIWSFMGP----VALIIL--------------------------------
-----INLVFYFQVLWIL-RSKLSSLNKEVST-I--QNT--RVMTFKAISQLFILG--CS
WGL-GFFL-VEEVGKTTGSIIAYMFTIINVLQGTLLFVVHCLLNRQVQM--EFKKWFSGV
RKGVE-TE-SSEV-------FR-SATQTK-MEKLE-KSS-EFFCKKDSAS-I--------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SLMLA-----TGDMGI----------RCLLRATALGVL----------------------
----------------------------LVWSI-LQL-----KNTSASCPQCHENASCYN
S-THCICKDGFWAGPDKGI-IIE-PH-VKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1062)

DINE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------LLE-VLVCKDVSYCKN-KIGTYTCSC-------IIKY-PIF-------------
-----NWV------AGI---------------------------------IDIDD-----
---------------------------PNCYVNN----------GKK-IG-T-QA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------DIWGEW---S---------------E-
RESKKNFAKRATTVLHQVGRH-ILD-EYSGV---P-MKGENSTLG-----IVYETKSCNS
-------MIL-LE------A-----------------GNN---------TMEI---DCTS
ALKES-------KSR-D---ETAVALIAYQSL-----GRFL-NESFFSN--------NEG
-----IQK-----------------VKLNSLI-VSGAIHSE---VKPV-LSEP-VLLT--
-----L-QNTQ------------------P-ID-PRAEHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVH--WEGS--EEGGSWST
K-GCSHM-YTND-SYT-ICKCFQ-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---S---LEED-SVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSVITYVGLSLSLLCLFLAIVTFLLCQPIQNT-STTLHLQLSICLF
LADLLFL-TGINRTEP-------K---VLCS---LIAGMLHYLYLASFMWMFLEGLHLFL
TVRNLKVANYSSS-GRFKKRFMYPVGYGIPAFIVAVSAIAGHENYGTH---TH-CWLSI-
-H------RAFIWSFLGP----VAAIIL--------------------------------
-----INLVFYFQTIWIL-RSKLSSLNKEVST-L--QDT--KMMTFKAIVHLFVLG--CS
WGI-GLFM-VIEFGKTVRLIIAYLFTIINILQGVLIFVVHCLLNRQVRM--EYKKWFYKM
QKGVE-NE-STEM-------SY-STTHTK-M-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------KIGDPY-------------------------------
-----WFL------TNL-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------TSRG---------------T-
TENHKEETRLVTVYLQSMEAA-VLA-AASRNTEET-QKVEGPSM-------AIETRRVKN
C--LLKKTFR-LK------A-----------------EKQ---------TMDI---HCTT
VEKES-------SGG-I---PGVVAFISYASI-----GPII-DKSFVSE--------ENL
MTKEKLHN-----------------FYLNSKV-VSGTMGSR---KNTS-LSMS-INFT--
-----F-QHEK------------------M-KR-EN

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

EQSV-CVY--WQ------GSSWSN
E-GCQVI-SSDE-NQT-LCSCNH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAS---TK--LKVD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PV---
--------------LTMITYVGLSLSLLCLLLAALTFLLCQPIQNT-STSLHLQLSICLF
VAHLLFL-TGIDRTEP-------K---VLCS---IIAGLLHYLYLASFTWMLLEGLHLFL
TVRNLKVANYTSA-GKFKKKCMYPLGYGIPALIVAVSAIVGPQNYGSH---TH-CWLKL-
-D------KAFIWSFMGP----VAVIIL--------------------------------
-----INLVLYIQILWIL-RSKLSSLNKEVST-I--QST--RVMTFKAIAQLFILG--CS
WGL-GLFM-VEEVGKVIGSVIAYTFTIINVLQGVLLFVVHCLLNRQV-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------E-
-G-----GKVFS-----ELLGVLLT-LSGA----GTQK---SKACAPWCPARSTCV----
------------------------------------------------------------
-----------------------------------------------------------N
GTACRCDAGFTSTSGEI-F-------------------------------T--ERTDMCE

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1075)

DINECAPPR-SLSCGKFADCQN-MDGSYYCTC-------NPGYRLISGE--KVFKDESQN
TCQGVVSRSQ------------------------------------------T-------
ELVSHHFQGCLRRVGAPTGALIPGGNRVG----T--EPS-----FLS-PDVN-ECTSGQN
P----------CH--SSTHCMNKAGGYQCLCR----PGW--RPIPGAPNGPNST-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1314)

DVDECSSGQHQCHNST--------VCVNTQ---GSYKCRCRQGWKPIAGSLNGRINTI-
--------------------------------------CEEIH-LPTWT-PPHGIHSQ--
-------------------------------------------------TLSGFLDK---
----------------VQALSRDFK--PALANVTIQN---LMQRVDELLE---SPGDLQ-
TLPHSQQHCVATHLLADLE-QT-LQSLGKNLPQGP-FTS---------------------
-SYPAGTELS-LE--VQE-Q-----------------GVRNVTLSQSQAKM-Q---LDWK
PAWES----GD--TG-----PSVVGLVSTPGM-----AKLM-AEAPLDLD----------
--HEKGAAPY----ETHEGFLQAWPPVLLSDV-VSAFVSSR---NTEN-LGST-VALT--
-----F-SHRPV-I---------------------QEPRL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1838)

CVF--WEQS-HSGCGHWAS
A-GCRTE-SSRG-DST-TCRCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MGY--DGA--QARD----PV---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LRSVTRVGLALSLLCLLLAALTFLLCRTIQNT-STSLHLHLSLCLF
LAHLLFL-TGIDQTQP-------K---VLCA---TIAGALHYLYLASFTWMLLEGLHLLL
TARNLTVLNYSRGGSRLTKQLLLPVGYGVPAVMVAVSAVARPQLYGTPA---R-CWLNS-
-E------KGFLWGFLGP----VCAVFL--------------------------------
-----INLAFFLMTLWIL-QSKLSSLSRDVST-FQHQNT--RTLTFKAMAQLVILG--CT
WGL-GFLQ-VGP----AARVMAYLFTGINTLQGVFIFLVYCILSQPVRE--QYRTWMERM
RASRG-ESETYVL-------SS-RGSD---TSSPSTVR----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LKGLSK---------------------------------
----------------------------------VLFLYCL-------------------
--MQGG-------------WEGHLLYI------VLPTNKGSNCLNPTACPNNSRCIETGK
E-YYCSCNPGFTLASGDCI-FTD--PNEKCEDQDECAD----P-TVCPQYSICISTPGNY
IGSCKSSFVMRNRKNP------VMECQGRI--------NL--------FPCHRILFGTQD
GGHCECKPGFSQTIGEK--------H-----------------------LLVRGVLGKSP

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1067)

DVDKCM--D-VTACPAHAMCTN-APGNYSCTC-------NLGSKSSTSE--VSFRNQG--
-----------------------------------------------TQCKRISPYMKV-
W-----------------------------------------------------------
------------------------------------------------------------
----------SDCGPLS--------VGSHVF---QQRSLQSNQGRHY-------------
--TKK--DE-K-W-GVGRSI------------------------PE-C-------K-EDL
-----DQ--E-QV---QDCHSNSTLP---GLP--------EYTS---FC-----------
----------TLVDSIFNVLEDTCENKTTT--VSLE---KAAEKLTSVLE---DASTWH-
NLNKKETSTLAIIFLDSVESAT-LE--AFDSLSG------NASQTVTNEYLETESKVIQD
DCLAENLVLS---------A-----------------KGD---------SMKI---ECST
INEAI-------SSG-----ITGVAFTSLLGM-----ESIL-DENFFYNP--------EA
NLTSSPQR---------------LW--MNSHI-IGGIITGN---KKDG-FSNP-IIYT--
-----L-ENL---Q---------------P-KK-RSDISI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1838)

-CVS--WDIN-VEGG-RWTP
K-GCVTL-HSTE-THTQ-CSCNH-LA----NM-AVI-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MA-S--GE--ITMD----FA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2069)

-LFVISHVGMILSLVCLALAIATFLLCRSIQNH-NTTLHLHLCICLF
LAKLLFL-TGVAKTEN----------KMVCA---VIDGLLQYLFLACFAWMWVEAVMLFL
MARNLKLVNFFGS-QNIKVFYLCAFGYGLPALIVEVATGSQWEGYGMHN---H-CWLHT-
-D------TGFIWSFVEP----VCTVIMVCKSLVKIGKRGRRKEFNPRPVLHFITTRLKF
LIFLQINSVLLSWTLWIL-RKKLSSVNGEVLT-F--KYN--RVLAFKAFAQLFILG--CS
WIL-GISQ-IGP----IARTMAYLFTIINSQSHSYHFLFLAFLNLQVRE--ENKKCFTGK
TKSST-IPQTSGI-------WLSSMPTTSKMI----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

METKEEVANWRLREEVAGWRPGRRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX---------
--------------------XXX-----XX-X-----XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------------------
------------------------------------------------------------
--------XXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX------------------XXXXX---XXXXXXXXX-----------
---XXXXXXXLQCI----TS----------------GL------------------LFL-
-L-----GPLTCPLCVTGLLCVLLS-LSRA----RAWD---FQPCNPWCPRNSECV----
------------------------------------------------------------
-----------------------------------------------------------N
ATACRCKPGFASSSTEI-F-------------------------------T--NPLVTCH
GVSPWASLQ--LQGKKGGECQW---GSWVREKVVKQRKLLPASMGPGGI--QEWVGRSQD
PSR----EMLVPR-----------------------------------------------
--TQREKGKCMNVGGPYGCTLCHVYIPWP-------KDP-----EGC-MERS--------
GTGKAWDTPGLAH--SSKH-TQEYRGWRSVCG----EHW--SWLQQEPTP--LS-M--S-
P

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1309)

DMDECSSGQHKCHRST--------TCTNTW---GSYSCQCRPGWEPIPGSVNGFYNNIC
K---------------------------------------VMP-FFTRP-LPPGVHSQ--
-------------------------------------------------SLSRFFEK---
----------------VKNLPRDLK--SAMAKDTIQE---IMQEVNELLE---TPEDLE-
TLPPSQKHCVATHLLTGLE-SA-LRNLSRGLPEGT-ATF---------------------
-NYSAGTQLS-LE--VQE-R-----------------GDGNVTLSLNQAKM-Q---LNWS
LAQES----DH--RG-----PSVVGLVSTPGM-----GKLL-AKAPLVLE----------
--LEKQVAPH----GTHKDSLLTASPVLLSDV-ISVFLSRK---DTQN-LSSP-VTFT--
-----F-SHPL-VT-----------------SE-PKREVL

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVF--WDHG-QNGCGHWAT
A-GCKTL-GTKD-GST-TCHCTR-LS----SH-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAS--YNV--QDND----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LDFITCVGLGVSLLCLVLAALTFLLCRAIQNT-STSLHLQLSLCLL
LAHLLFL-TAIDRTQP-------K---VLCA---VTAGALHYLYLASFTWMLLEGLFLFL
TARNLTVLSSSSR-NRLMRRLMFPVGYGVPATIVAVSAAARPHLYGTST---R-CWLRP-
-E------QGFMWGFLGP----VCAISS--------------------------------
-----VNMVFFLMTLCIV-KSKLSSINRDVST-L--QNT--RVLTFKAMAHLFILG--CT
WCL-GVLQ-VGP----IAPIMAYLFTIVNSLQGVFIFLVYCLLSQQVQE--QYKKWLKRI
WKWTT-ESESYTL-------SS-KVVSDT--SRPSTVGSLPD-P----------------
-----------RAHVPWYWHHFSPPVHRPCFPCLLDSTIM----------PACALTLHDS
LSLPPL---------------------HLLPTYYHCVP---------------TLI----
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWGFRLL--------------
LFWGCTGMHRWG--MTMLPTLGQ--K-----------G

PF07645 // ENSGT00900000140800_1_Domain_1 (399, 434)

VNECEDTTTCPAYATCNDTVDS
YYCT-CKRGFLSS

ENSGT00900000140800_1_Linker_1_4 (434, 450)

NGQ--KHFRGPGVECK

PF07645 // ENSGT00900000140800_1_Domain_4 (450, 686)

DVNECVES-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-TPCGPNSICINIPGRAKCSCLSGFSSPTG--NNWILGSSGQFLCTDIDECLT-SRVCPE
HS------------------------HCS---NYVGSYSCS-------------------
--CRPG-------------FVSSGS---------TCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DEDECENPNACPEYATCHNTVG
S-YYCMCNSGL

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ESSGGGTM-FQG--LEQSCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECAK---NS-SLCSPTFICVNTLGSY
NCSCLSGFALSV--SQIHGHPIE-------------------------------------
--------------------------------------------------------EKCI
DIDE----C-DDICPFNSTCTN-IPGSYFCTC-------HSGFAPSNGE--VDFTDPE--
-----------------------------------------------VSCG---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1323)

DIDECSQDPSPCGRNS--------VCTNVP---GSYICGCPAGFRPN--------PE--
-GSQT--YV-N-F-SCKR-V----------------------P-FK-C-------K-EDM
---IPNN--E-QL---RQCQAQA--G---RDP--------GHVS---FC-----------
----------ALVNSTFSILDNTCENKTRP--VSLQ---STAKRFSLVLN---NTPTWT-
KLTQEETSTLGTVLLESVESTT-LA--ALLKPSG------NASQTIQTEYLDIESKVINA
ECNRENASFN-LK------A-----------------KGD---------EMKV---GCSV
IEESE-------SAG-----TIGVAFVSFAHM-----ELVL-DERFFEDN--------ET
SWTKSKRK---------------LK--MNSRV-VGGIMTGE---KKED-FSSP-VIYT--
-----L-EHI---Q---------------P-MQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WNTS-VGDG-RWTT
L-GCKIL-EASE-MHTV-CSCNR-LA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYAISHVGIIISLVCLALAIATFLLCRAIQNH-NTYLHLHLCVCLF
LAKILFL-TGIDKTDN----------QTACA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RRVKMVHLCAFGYGLPGLVVIISTSSQPHSYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTIIV--------------------------------
-----INFVLLTWTLWIL-RQKLCSVNSEVSK-L--KDT--RLLTFKAIAQIFVLG--CS
WVL-GIFQ-IGP----LASIMAYLFTIINSLQGAFIFLIHCLLNRQVRE--EYRKFIIRK
TEPSS-HSQTSGI-------LLSSMPSTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MGS----------RCLP---LLSGLSVL-------------------
-----------------LAL-----------SG-SDA-----KNSGAFCPMCPENASCFN
S-THCACKDGFQSASGGRY-I-K-PH-EKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KAG-LSKCKNKAYCRN-KIGSYYCSC-------IS-N-SIF-------------
-----NWV------ASF---------------------------------IKVDR-----
---------------------------EACYEGT----------SKG-TS----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SS--GNIQEILRNNG---------------T-
TKEQ--IAKIATQLFQEMEVN-IWT-EGLAS---P-GKYDNSTLG-----IVYEIKRCNE
----TSEKTV-LE------A-----------------GNN---------TMNI---NCTD
AFKGT-------TRD-----KSAVAIITYQSF-----GDIL-NGSFFND--------ERG
-----TQE-----------------MKLNSRV-VSGTISMK---KKVR-LSKP-VFLT--
-----F-QHIQ------------------P-GV-ERT

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KPF-CVF--WEGS--EEGGTWST
K-GCYHV-HSND-SHT-KCKCFH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MDF----V--PKVD----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITYVGLSLSLLCLLLAALTFLLCRSIQNM-STSLHLQLSICLF
LAHLLFL-TGINQTKP-------E---VLCS---IIAGVLHYLYLAAFTWMLLEGLHLFL
TVRNLKVANYIST-GKFKKKFMYPFGYGIPALIVAVSAVIGPQNYGTH---TH-CWLKF-
-D------RAFIWSFMGP----VAVIIF--------------------------------
-----INLVLYFQILWIL-RSKLSSLNHEVST-I--QDT--RVITFKAIAQLFILG--CS
WGL-GFFM-VEELGKVIRLVMAYTFTIINVLQGILLFVVHCLLNRQVRM--EYKKCFSGI
CKGAE-TE-STDV-------TH-SMTQMK-MEELR-MSS-EVFPRRDLAS----------
-----------------W------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----WW-------THFGLN-NC--------------FRL---------------------
-SGVSTKEWN-CW--VQK-Q-----------------VDRNVTLRQNQATM-Q---LHWN
LAQKS----GD--PG-----PSVVGLVSVPGM-----GKLL-AEAPLVSE----------
--PEKQVVLN----ETHQGLL----PILLSDV-ISAFLSNN---DTQN-LSSP-VTFT--
-----F-SHRS--------------------VI-PRRKVL

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVF--WEHG-QNGCGHWAT
T-GCSTM-DTRD-TST-ICRCTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAP--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSLSLLCLLLAALTFLLCKAIQNI-STSLHLQLSLCLL
LAHLLFL-MAIDRTEH-------E---VLCA---IIASALHYLYLAAFTWMLLEALYLFL
TARNLMVVNYSSI-NRFTKKLMFPVGYGVPAVTVAISAASRPHLYGTPS---R-CWLQP-
-E------KGFIWGFLGP----VCAIFS--------------------------------
-----VNLALLLVTLWIL-KNRLSSLNNEVST-L--QNT--RMLAFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWSKGF
RKLRT-ESEMHTL-------SS-SAKADT--PKPSTVRSRIA-P----------------
-----------EHFTNR------PT-----------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MLMGA-----TRDMGS----------RCLLHASVPGML----------------------
----------------------------LIWSI-LQM-----MNISASCPQCNENASCFN
S-THCVCKEGFWTGSENRR-IIE-PH-EKCQ

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DINE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------LLK-ELVCKDVSYCRN-KIGTYICSC-------VVKY-PLF-------------
-----NWV------AGI---------------------------------INIDH-----
---------------------------PDCYVNK----------SKN-TG-S-K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------THTLGVL---S---------------E-
FKSKEEVAKGATKLLRKVEHH-ILN-ENSDI---P-KKDENPLLD-----IVYETKRCKT
-------MTL-LE------A-----------------GNN---------TMKV---DCTS
GFKEH-------NSG-G---ETAVAFIAYKSL-----GNLL-NGSFFSN--------EEG
-----FQE-----------------VTLNSHI-VSGAIRSE---VKPV-LSEP-VLLT--
-----L-QNIQ------------------P-ID-SRAEHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVH--WEGS--EEGGSWST
K-GCSHV-YTNN-SYT-ICKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---P---HEED-GVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSVITYVGLSLSLLCLFLAAITFLLCRPIQNT-STTLHLQLSICLF
LADLLFL-TGINRTKP-------K---VLCS---IIAGMLHYLYLASFMWMFLEGLHLFL
TVSNLKVANYSNS-GRFKKRFMYPVGYGLPAFIVAVSAIAGHKNYGTH---NH-CWLSL-
-H------RGFIWSFLGP----AAAIIL--------------------------------
-----INLVFYFLIIWIL-RSKLSSLNKEVST-L--QDT--KVMTFKAIVQLFVLG--CS
WGI-GLFI-FIEVGKTVRLIVAYLFTIINVLQGVLIFMVHCLLNRQVRM--EYKKWFHRL
RKEVE-SE-STEV-------SH-STTHTK-MGLSL-NLE-NFCPTGNLHDPS-----DSI
LPS--------TEVAGVYLST-------------PRSHM----GAEDVNSGTHAYWSRTI
SD----------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------W-TFGL----FPSLCY---SSCAKCPPNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NTHCTCDHGYTSGSGQELF-------------------------------T--FPLETCN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1081)

DINECTPPY-SVYCGFNAVCHN-VEGSFYCQC-------VPGYRLHSGN--EQFSNSNEN
TCQDTTSSKTTQGRKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDKF----------------------------ESLLTNQ-TLWRRE------------
--------------------------------------------------GRQEISST-A
TTILRDV--E------S----------------------------NV-------L-----
----------------ETAL-------KAP-EQKVL----------KI------------
----------QND-SVAIETQVITD-------NCS-------------------------
---EERKTFN-LN--VQ-----------------------M-------NSMDF---RCND
VIQGD-------TQG-----PSAIAFISYSSL-----GNI--INATF-FE---------E
TD--KKDQVY-----------------LNSQV-VSAAIGPK---RNMS-LSKS-VTLT--
-----F-QHVK------------------M-NP-STKKVF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKST--GQGSQWSR
D-GCFLI-HVNK-SHT-MCNCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---TS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYVGLSVSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-VGIDRTEP-------K---VLCS---IIAGALHYLYLAAFTWMLLEGVHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASWPHLYGTAD---R-CWLHL-
-D------QGFMWSFLGP----VCAIFS--------------------------------
-----ANLVLFILVFWIL-KRKLSSLSSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GLLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREI
VKSKS-ESETYTL-------SS-KMGSDS-KPSEGDV-----FP----------------
-----------GQVKRKY------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MPRASLLPELCFLLS-LSGT----VARKAP---PSCRPCPVKASCV----
------------------------------------------------------------
-----------------------------------------------------------N
YTSCTCDSGYASSSG-KFF-------------------------------T--FPLVECN

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECEPPI-SVYCGLNAECQN-VQGSFHCHC-------VSGYRLLSGN--TQFKNSNEN
TCQNTASSKTPPT-----------------------------------------------
------------------------------------------------------------
--------------------------------------------KANKE-LQQ-------
-VVNKV----------------------------EEFVTHN-TLWNKT------------
--------------------------------------------------EKREVASL-A
TSILHSV--E------L----------------------------HA-------L-----
----------------ETAL-------NSP-DQKVQ----------KV------------
----------HKN-SVAIETRVVGN-------NCS-------------------------
---AERKMLS-LQ--AQ-----------------------M-------NTLDI---LCKD
VVQGN-------MQG-----LNALAFISYASL-----GDI--INATF-LK---------E
MN--ESNQLY-----------------LNSQV-VSAAIGPK---RNTS-SSKS-VTLS--
-----F-RHTK------------------M-KP-NG

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1848)

KKVF-CVY--WESS--KEGGHWAT
D-GCFLK-DVNE-SYT-VCSSTH-LS----SF-AVL-IAF---TS--

ENSGT00900000140800_1_Linker_21_22 (1848, 1855)

QEED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PV---
--------------LTVITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSIHLQLSLCLF
LAHLLFL-IGIDQTEP-------K---VLCA---IIAGALHYLYLAAFTWMLLEGLNLFL
TARNLTVVNYSSV-SRFMRKLMFPVGYGVPAVIVAISAAARPHLYGTSA---R-CWLHL-
-D------QGFIWGFLGP----VLAITC--------------------------------
-----VNLVFFLSVLWIL-HRKLSSLNSEVST-V--QNT--KMLTLKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVWK--QYRGWFSRI
VKSKS-EMEINTL-------SS-RAGPDS-KPSK--------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHTGPTLKPT------------TKD

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 435)

NKCRDSTMCPSHATCTSTVDS
YYCA-CKQGFRSSNGQ--NHFKDPGVECKGEFISPQ------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
TL--QHLVVKSSKSG---------------------------------------------
------------------------------------------------------------
------------------------L---------GIE-YD

PF07645 // ENSGT00900000140800_1_Domain_10 (821, 853)

NECANPRMCPEHATCNNTVG
N-YSCFCDPGFESSSGHLS-FQG--LKC--------------------------------
------------------------------------------------------------
-----------------------------------------------------------E

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1067)

DIDECT-----EMCPINSTCTN-TPGSYFCTC-------HPGFASSNGQ--LNFTDQK--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1322)

DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPN--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDM
---IPDN--E-QV---QQCQERT--T---VKP--------EYVS---FC-----------
----------AQINNIFSVLDKVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
NFTKEETSSLATVFLESVESLT-LA--AFLKPSA------NVTQTVRTDYLDIESKVINK
ECSEENVNFS-LA------A-----------------KGD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2069)

-LYVISHVGMIISLVCLVLAIATFLLCRSIRNH-ITYLHLHLCVCLL
LAKILFL-AGIDKTDN----------QTGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAVGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIAVSKYDNSLAKCVLKAEQGDLRDLEFP----RT
CAAERVTYSR--------------------------------------------------
--------------------------------------------QDTEK--KYKRWITGK
NKPSS-QSSMDFHTLKTKKIKMSHYPTT--------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
SLMVA-----TGDMGI----------RCLLHATALGVL----------------------
----------------------------LVWPV-IKL-----QNASASCPQCNENAACYN
S-THCICKDGFWTGPDSRI-IIE-PH-VKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1065)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QLG-IPVCKDVSYCKN-KIGDYICSC-------VVKY-RIF-------------
-----NWV------AGI---------------------------------VDIDN-----
---------------------------PDCYVNS----------GKK-IG-P-QA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------DIWGQL---S---------------G-
QESKKNFAKIATDILHKVELH-ILN-ENSAV---P-TKGENSSLG-----IVYETKRCSS
-------MIL-LE------A-----------------GNN---------TMEI---DCAS
ALKGI-------KNG-D---ETAVALIAYQSL-----GKYL-NESFFN---------NKG
-----IKE-----------------VKLNSLI-VSGAIHSE---VKPV-LSEP-VLLT--
-----L-QNTE------------------P-ID-PRAEHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVH--WEGS--EEGGSWST
K-GCSHM-HTND-SYT-TCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---S---LEED-SVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSVITYVGLSLSLLCLFLAAVTFLLCRPIQNT-STTLHLQLSICLF
LADLLFL-TGINRTEP-------K---VLCS---LIAGMLHYLYLASFMWMFLEGLHLFL
TVRNLKVANYSSS-GRFKKRFMYPVGYGIPAFIVAVSAIAGHENYGTH---TH-CWLSL-
-H------RAFIWSFLGP----VAAIIL--------------------------------
-----INLVFYFQTIWIL-RSKLSSLNKEVST-L--QDT--KIMTFKAIVQLFVLG--CS
WGI-GLFM-VFEFGKTVRLIIAYLFTIINVLQGVLIFVVHCLLNRQVRM--EYKKWFNKM
QKGVE-IE-STAM-------SY-STTNTK-T-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MQGSS---LLPGLCFLLS-FFGA----VIPKIK---ASC-NCPPNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
NSHCTCNSGYISRSGQTLF-------------------------------T--FPLETCN
DINECEPPY-SVYCGSNAACHN-VAGSFHCHC-------VPGYRLQSGE--ERFSNSSEN
TCQDTNS

PF16489 // ENSGT00900000140800_1_Domain_16 (1088, 1719)

SKTTQGKKE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQK-------
-IVDTF----------------------------ESLLTNQ-TLWRTE------------
--------------------------------------------------GRQEISST-A
TTILQDV--E------S----------------------------KV-------L-----
----------------ETAL-------KVP-EQKVQ----------KI------------
----------QNS-SVAIETRVITD-------NCS-------------------------
---EERKTFN-LN--VQ-----------------------M-------NSMDI---HCND
VIQKD-------TQG-----PSAVAFISYSSL-----GNI--INATF-FE---------E
TD--EKDRVF-----------------LNSQV-VSAAI

ENSGT00900000140800_1_Linker_16_21 (1719, 1782)

GPK---RNVS-LSKS-VTLT--
-----F-QHVK------------------M-NH-SIKKAF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WETT--KQGGLWSR
D-GCFLI-HVNK-SHT-MCNCSH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAF---TS--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTIITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
VAHLLFL-VGIDQTES-------K---VLCA---IIAGALHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYSSI-NRLMKWIMFPVGYGVPAVTVAISAASRPHLYGTAD---R-CWLHL-
-D------QGFIWGFLGP----VCAIFS--------------------------------
-----VNLVFFILVFWIL-KRKLSSLNSEVST-I--QNT--RMLAFKATAQLFILG--CT
WCL-GFLQ-VGP----AAQVMAYLFTIINSLQGFFIFLVYCLLSQQVQK--QYQKWFREI
VKSKS-ESETYTL-------SS-KVGPDS-KPSEGDV-----FP----------------
-----------GQVKRK-------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------YCTCKQGFLPSNRQTNFTGPGVDCTVESKPLH
KPPAFGREVRWK--MASLPMLIVRT---SN-IYGLLSLGGQMVNVLSCPLRSQ---RTQG
HLHTQNEGGTPKSHCA--EPLVTPLFLCPDVDECSHTPPPCGPGSVCTNLRGRHRCSC--
LPGFSSPTEITWIPA--YL--LCSSDIDGCL-----------------------------
------------------------------------------------------------
--------SSA-TCLENSDCMKAVGSYSCSCRVGFI-PG-------TPPVKR

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 694)

DVDECA-N
PRACPERPICNNTVISHSCFCNPGFEPSSS--NLTFQGLGESTGCVD--RCIENKGFCNL
STVIH-----DNFMGQKGVEPCAPNLDSPAPWSPLRHLDNITTKKQKRSDFPVPTPPKKI
CKFTLNSFFYYCKKDLKPGPRNICN---SSCQD-VNK-----CDNSTVCPAKSICNNFTE
G-YNCSCEAGYESSSGEKE-FTD-PG-VTCEGEYYLAL---SG-QECWPR-ICEKVWPSI
KCICNVGGASPSGMDAVLPGQLSHC-----------------------------------
----------------------------------------------------------CQ
PEENE-CWG-PMLCLSIATCNN-TVGSYFCVC-------RLGFVSTA-------------
-----G---------GC---------------------------------V

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1195)

DVDECL-N-
PGVCPENTICRNIPGSY-RCTRKPSFTPSGYS--------------T-IP-F-LCS----
-----PE-VWPCV--S---------------------EY--LPCTRWD---LF---MIC-
-------RIAA-----S------------------NT-----------------------
------------------------------------------------------------
-----------------------------------------EEWGKFFL--L-FITTSGV
IWDQ---MDNSNSKEIV-----ERKEIANS--FNLLTNVTSQL---------------P-
TRSHK--EAAVSEYLEVMQTA-SYE-AALKRPTEGTHREETK--L-----IAIETLTLKR
GCKEEGETFE-LK------A-----------------KGN---------SMDI---DCSI
ITEGG-------TGG-----NRAVAFISYDYI-----GSII-NGSFSST--------ENL
TVGEKLEN-----------------FELNSKV-VSCTIGPR---KTAT-LATP-VNFT--
-----F-QHLQ------------------V-IG-EH

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

EKTI-CVF--WD------NTGWST
A-GCQDI-FSNG-TQT-VCSCNH-LS----TF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAS---VV--LTED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PV---
--------------LVMITYVGLSLSLLCLLLAALTFLLCRPIQNT-GTSLHLQLSLCLF
LAHLLFL-TGIDRTEP-------K---LLCS---IIAGALHYLYLASFTWMFLEGLHLFL
TVRNLKVANYTSA-GRFKKGFMYPFGYGIPAAIVAMSAGLKPHGYGTS---VH-CWINL-
-Q------HGFMWSFIGP----VSVVIL--------------------------------
-----INLTFYLITLWIL-RARLSSLNKGVSK-I--KST--RMLTFKAIAQLFLLG--CS
WCL-GFLL-VESIKEPFRSVIAYAFTITNVLQGVYIYMVHCVLNQQV-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------CCG--------------
IFGQAM---------HTVPTLTK------------TS

PF07645 // ENSGT00900000140800_1_Domain_1 (398, 443)

DVNECEDISTCPTHAGCVDTTGS
YYCT-CRQGYQSSNRQ--RHFKGPGVICE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------XXXXXXXXXXXCPSECTNMG--EYCSCFPGFSSPTG--NNWNPGKPGHFACTXXXXXXX-XXXXXXXX--------------------------------------------------------------X---------------X---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------XXXX-XXXXXXXXX-------XXXXXXXXXX--XTFTDQE-------------------------------------------------GQSR----------------------------------------------------------------------------------------------------------------------------------DIGECHKDPSQCGPIS--------VCTNTM---GSYNCSCIEGFRSD--------P-E-V-SQ-R-YG-N-I-TC-KXI----------------------L-FK-C-------K-ED-V-L-PN-S-E-RI-Q-Q-CQ-Q-G-V-V-A-P--------L-GSVGSFC---------------------DLTNTILDVLDEACENKTTP--VSLE---DTAETFAAVLE---QTIT-S-NLSKEETSTLATVFLESVEATT-LA--ALLKPSE------NASQIIQTEYLDIESKVINKECNEE-DGFT-LK------A-----------------KGD---------EVKI---RCSTIEESK-------STG-----PLRVAFLSFEGM-----ESVL-DERFFQDP--------QSPLASSRMK---------------LR--MNSRV-VGGVITGE---KKAN-FSDS-IIYI-------L-KNI---Q---------------P-KQES-ERPI-CVS--WTTD-GKGG-RWTPI-DCVIL-EASK-TRTV-CGLNR-MT----NL-AII-MA-S--GE--LTXX----XX-----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---X-XXXXX--X------XXXXXXXXXX----XXXXXX-------------------------------------INSILLTLTLWIL-RQKLSSVNAEVSS-L--KDT--RILTFKAFAQLFILG--CSWVL-GIFQ-IGP----VAAVMAYLFTIINSLQGAFIFLIHCVLNHQVRE--EYRRCLTRKRKSSF-QSQTSGV-------LLSSIPSTSKTS-----------------------------------------------------------------------------------------------------------------------

PF07645 // ENSGT00900000140800_1_Domain_2 (398, 443)

DVNECEDISTCPTHAGCVDTTGSYYCT-CRQGYQSSNRQ--RHFKGPGVICE-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------XXXXXX
XXXXXCPSECTNMG--EYCSCFPGFSSPTG--NNWNPGKPGHFACTXXXXXXX-XXXXXX
XX----------------------------------------------------------
----X---------------X---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------XXXX-XXXXXXXXX-------XXXXXXXXXX--XTFTDQE--
-----------------------------------------------GQSR---------
------------------------------------------------------------
------------------------------------------------------------
-DIGECHKDPSQCGPIS--------VCTNTM---GSYNCSCIEGFRSD--------P-E-
V-SQ-R-YG-N-I-TC-KXI----------------------L-FK-C-------K-ED-
V-L-PN-S-E-RI-Q-Q-CQ-Q-G-V-V-A-P--------L-GSVGSFC-----------
----------DLTNTILDVLDEACENKTTP--VSLE---DTAETFAAVLE---QTIT-S-
NLSKEETSTLATVFLESVEATT-LA--ALLKPSE------NASQIIQTEYLDIESKVINK
ECNEE-DGFT-LK------A-----------------KGD---------EVKI---RCST
IEESK-------STG-----PLRVAFLSFEGM-----ESVL-DERFFQDP--------QS
PLASSRMK---------------LR--MNSRV-VGGVITGE---KKAN-FSDS-IIYI--
-----L-KNI---Q---------------P-KQES-

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

ERPI-CVS--WTTD-GKGG-RWTP
I-DCVIL-EASK-TRTV-CGLNR-MT----NL-AII-MA-S--GE--LTXX----XX---
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---X-XXXXX-
-X------XXXXXXXXXX----XXXXXX--------------------------------
-----

PF00002 // ENSGT00900000140800_1_Domain_22 (2106, 2207)

INSILLTLTLWIL-RQKLSSVNAEVSS-L--KDT--RILTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAAVMAYLFTIINSLQGAFIFLIHCVLNHQVRE--EYRRCLTRK
RKSSF-QSQTSGV-------LLSSIPSTSKTS----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------CGPNANCIN-QHQYYYCTC-------ADGYKSSSGK--ASFLHASEN
SC------------------------------------------------R

PF07645 // ENSGT00900000140800_1_Domain_14 (1132, 1259)

DIDECLGPP
GVT---------------------------------------------------------
-----------CG--PNANCTNLSGSFYCTCA----DGY--VQSSGKARFPNAN-ENSC-RGVPSSHPLHGRLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSETTRS--FNSFLNRTSLG---------------S-SIGEGEVALAVTVLLQSVERV-ALA-AALQSPGRMTQKMSTES-------IAIETRVITGNCSQHSEVFR-LS------A-----------------QGE---------TMEV---HCTTVTHAA-------TQEPSWHLGAAAAFIAYSSL-----HSTI-NARLPSS--------GSLWAGRMLEK-----------------SHLGSRV-VSGAVGDG---GPIC-LSRP-ANFT-------L-RHQQ------------------P-RK-EQEVAL-CVY--WKFE--AGKGSWSLD-GCTTL-HVNS-THT-TCSCDH-LS----SF-AIL-MAP---SA--AMES----RP-----------------LTILTYVGLSLSLLCLLLAILTFLLCRSLWNV-STALHLQLCLCLFLADLLFL-SSQGV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF07645 // ENSGT00900000140800_1_Domain_15 (1132, 1259)

DIDECLGPPGVT--------------------------------------------------------------------CG--PNANCTNLSGSFYCTCA----DGY--VQSSGKARFPNAN-ENSC-
RGVPSSHPLHGRLK----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------LSETTRS--FNSFLNRTSLG---------------S-
SIGEGEVALAVTVLLQSVERV-ALA-AALQSPGRMTQKMSTES-------IAIETRVITG
NCSQHSEVFR-LS------A-----------------QGE---------TMEV---HCTT
VTHAA-------TQEPSWHLGAAAAFIAYSSL-----HSTI-NARLPSS--------GSL
WAGRMLEK-----------------SHLGSRV-VSGAVGDG---GPIC-LSRP-ANFT--
-----L-RHQQ------------------P-RK-EQEV

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

AL-CVY--WKFE--AGKGSWSL
D-GCTTL-HVNS-THT-TCSCDH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAP---SA--AMES----RP---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 1930)

LTILTYVGLSLSLLCLLLAILTFLLCRSLWNV-STALHLQLCLCLF
LADLLFL-SSQGV-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------SQCCR--QRPQFATCINGTHCVCD----DGF--ASTSGEKYFSDSL-EI-C-
DXXXXXXXXXXXXXX-----------------------XXX-------------------
------------------------------------------------------------
-----------------------------------------------------XXXXX--
-----------XXXXX--XXXXXXX-------XXXXX--X---------X---XXXX---
--------------X-XXXXXXX-X-X-XXXXX---XX---X-XXXXX----XXXX----
--XXXX------------------------------------------------------
---XX-------XXX-----XXXX--XXX--X-----XX---XXXXX-X--------X--
-XXXXXXX------------------------------XXX---XX--------------
--------XXX------------------X-XX-XXXX----------------XX--XX
X-X-------XX-X------------------------------X--XXXX----XX---
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXA

PF00002 // ENSGT00900000140800_1_Domain_22 (1903, 2207)

IKGT-STFLHLQLSLCLF
LANLIFL-IGIKQTQP-------K---VLCS---LIAGGLHFLYLAAFTWMFLEGLHLFL
TVRNLRVANYTSA-GRFKKKFMYPFGYGIPAVIVAVSA-DGPQGYGTV---RH-CWLNI-
-E------KGFIWSFIGP----VFIIIL--------------------------------
-----INLSFYLTVLWIL-RDRISSLNKEVST-I--QNT--RTLTIKALAQLFILG--CS
WSL-GFFM-IDSIPKPVQSVIAYTFTIINSLQGVYIFLVHCVLSRQV-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------LSIL-------------------
-----------------LAL-----------SR-SEE-----MTSSASCAQCSENAVCFN
S-THCVCHEGFWSSAEKRL-FVE-PH-VKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1063)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------AFI-TPVCKEVSYCKN-KVGTYICSC-------VIKY-PII-------------
-----NWV------AGL---------------------------------FDIDH-----
---------------------------PDCYVKK----------TGS-ES-G--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------ELS---------------K-
SGTKKDFAKKVTKILQQVELH-IWS-ENSAL---P-TKGENTTLG-----IVYETKRCTK
-------RTL-LE------A-----------------GNN---------TMEI---NCTS
AFREA-------HRK-D---ESAVALIAYQTL-----GTFL-NGSFFSN--------EGG
-----MQE-----------------VKLNSLV-VSGTIRSE---VKGE-LSEP-VLLT--
-----L-QKTQ------------------P-GD-MKAEHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKGS--EEGGTWST
N-GCIHV-QSND-SYT-TCKCVH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---TP----EDSSVLFA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LSVITYVGLSLSLLCLLLAVLTFLLCQPIQNT-STTLHLHLSICLF
LAYLLFL-TGINRTKP-------E---VLCS---IIAGLLHYLYLAAFMWMFLEGLHLFL
TVRNLKVANYTSI-GRFKKRFMYPTGYGIPAFIVAVSAIVGHKHYGTS---TH-CWLSL-
-D------KGFIWSFLGP----VAVVIL--------------------------------
-----VNVVFYFQIMWIL-RSKLSSLNKEVST-I--QDT--KVMTFKAIVQLFVLG--CS
WGI-GFFM-LHEVGKTMRSAIAYLFTIINILQGIFIFVVHCLLNRQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------FFHFM--GL---LT-MLSVPTASTPED---C---AWWCPLNSKCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATACHCAQGFHSSSGEI-L-------------------------------T--SPFKRCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECEPSS-TVTCGKHADCQN-TEGSYYCMC-------NQGYELVSGA--KKFWKESEN
TCQESDDIQPS-------------------------------------------------
PSLVFLRCLSVSVEGEH-CFGSVNGIPRR----T--QSV-----RSC-SGEE----MQHF
P----------CPGFPRRHSLSSVQMSRLRHR----QGC--WELPGKFRGPGVA-D--R-
TAF-LSAPGISSSTSTGTGTGTGTRTGTGTG---TGTGTGTRTGTGTGTGTGT-----GT
GTG--------------------------------------TG-TGTGT-KHPGINNS--
-------------------------------------------------KVSSLLQK---
----------------FDDFDRDFK--SASDPDKIQD---LIQGVDDLLE---NPGDLE-
TLSHSEQNSVATTLLHRME-HVIFKKLSKAPPNGS-LTF-------------------N-
-AP-GGTELS-LK--IKK-Q-----------------GDRNVTLSVNQAKM-V---LDWD
TVQES----GD--SG-----PSTVGLFSTPVM-----GKFM-AKAPLVLE----------
--TEEQSVLN----ETHKGLLEEVSPVLLSDV-ISVFVSNN---NTQN-LSSP-VTFI--
-----F-KH------------------SVT-PR-PK

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEPG-QNGSGHWST
K-GCWRV-CTRD-TST-TCQCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYLGLSLSLLCLFLAALTFLLCKAIQNT-CTSLHLHLSLCLF
LAHLLFL-TAIDSTEN-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLTVVNYSSM-SRFMKKFMLPVGYGVPAVIVVISAASRPHLYGTPA---R-CWLST-
-Q------KGFIWTFLGP----VCTIFS--------------------------------
-----INLAFFLMTFWIL-KTKLSSLNRDVST-L--QNT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AAHAMAYLFTIINSLQGVFIFLVYCLLSQQVQE--QYRKWLKGI
KESKA-ISEKYTL-------SS-RAMSEV--SKDNVVR----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------SM-TDL-LSA---GS--QEED----PA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSLSLLCLFLAALTFLLCKAIQSI-STSLHLQLSLCLF
LAHLLFL-TAIDRTES-------K---VLCA---IIAGALHYLYLASFTWMLLEGLQLFL
TARNLTVVNYSSA-NRFMKKLTFPVGYGVPAVIVAISSASRPHLYGTPK---R-CWLST-
-E------KGFVWTFLGP----VCTIFS--------------------------------
-----INLVFFLITFWIV-KKKLSSLNSDVST-L--RKT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----APHVMAYLFTIINSLQGFFIFLVYCLLSQQVQE--QYKIWFKGI
KKKKT-ESEEYTL-------SS-RAILEP-SKHSEHGL----FH----------------
-----------AQTLKEE------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------AAAFISYNSI-----GLIM-NNTFISK--------EHL
NTDEELDK-----------------FYLNSKV-VSGTIGDV---KNGS-LAAP-INFT--
-----F-QHIQ------------------C-NI-SYR

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

QPF-CVY--WH------KTTWFN
D-GCHVI-FCNV-TQT-VCSCNH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1874)

MAS---SV--MKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITHVGLGVSLLCLLLAVLTFLLCQSIQNT-SISLHLQLSLCLF
LAHLLFL-TGIKQTKP-------K---VLCS---IIAGLLHYLYLASFTWMLLEGLHLFL
TLRNLKVANYTIT-KRLQKRFLYPFGYGIPVVIVAVSAGLNPHGYGTP---RH-CWLNL-
-K------GGLIWSFIGP----VSVIIL--------------------------------
-----INFIFYLTILWIL-RDRLSSLNKEVST-I--KNT--RTLTFKATAQLFLLG--CS
WGL-GFFL-VEPVKEPFRSVNAYAFTIINVLQGVYIFVIHCLLNRQVQE--EYKKYF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-INECATPS-KVSCGRFSDCWN-TEGSYDCVC-------SPGYEPVSGA--KTFKNESEN
TCQ

PF07645 // ENSGT00900000140800_1_Domain_14 (1084, 1178)

DVDE-CQQ------------------------------------------------N
PRLCKSYGTCVNTLGSY-SCQCLPGFKLK----P--EDP-----KLC-TDVN-ECTSGQN
P----------CH--SSTHCLNNVGSYQCRCR----PGW--QLIPGSPNGPNNT-V--C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1359)

DVDECSSGQHQCDSST--------VCFNTV---GSYSCRCRPGWKPRHGIPNNQKDTV-
--------------------------------------CEDMT-FSTWI-PPPGVHSQ--
-------------------------------------------------TLSRFFDK---
----------------VQELGRDYK--PGLANNIIQS---ILQALDELLE---APGDLE-
TLPHLQQHCVASHLLDGLE-DV-LRGLSKNLSNGL-LNF---------------------
-SYPAGTELS-LE--VQK-Q-----------------VDRSVTLRQNQAVM-Q---LDWN
QAQKS----GD--P----------------GM-----GKLL-AEAPLVLE----------
--PEKQVLLH----ETHQGLLQDGSPILLSDV-ISAFLSNN---DTQN-FSSP-VTFT--
-----F-SHRS--------------------VI-PRQKVL

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVF--WEHG-QNGCGHWAT
T-GCSTI-GTRD-TST-ICRCTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAH--YDV--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LTVITYMGLSFSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-VAIDQTGH-------K---VLCS---IIAGTLHYLYLAAFTWMLLEALYLFL
TARNLTVVNYSSI-NRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPS---R-CWLQP-
-E------KGFIWGFLGP----VCAIFS--------------------------------
-----MNLVLFLVTLWIL-KNRLSSLNSEVST-L--RNT--RMLAFKATAQLFILG--CT
WCL-GILQ-VGP----AARVMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYGKWSKGI
RKLQT-ESEMHTL-------SS-SAKADT--SKPSTPGTVVQ-A----------------
-----------CNASTL------GGQSRKIT-----------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-VDKC-TTG-RGRCRRSVRRTD-TFGSYHGNC-------IPRY-PFW-------------
-----NWV------AGI---------------------------------TDFHH-----
---------------------------PXXXXXX----------XXX-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------XXXXXEAVW---------------N-
HGTPKGIVQNVTKQLQNVIVN-MWN-EIFAS---P-DKYENPEFG-----IAYETSRCKE
T------REN-NE------A-----------------ENN---------AMDI---DCTH
VFEET-------TRE-------N

PF00002 // ENSGT00900000140800_1_Domain_22 (1644, 2207)

VALS---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------TELWGILSIQNT-STPFLLQLSICLF
LVHLLFL-VGIDQTEP-------A---ALCS---VIAGALHYLYLASFTWILLEGLHLFF
TIRNLKAANDTST-GRFKKSVLYPLGYGIPAVIVAVSVGLGHKNYGTN---TR-CWLKL-
-D------KGFIWSFLGP----VCVIIS--------------------------------
-----INFVLYFIILWIL-KSKLSSLNKDVST-I--QNT--RVMTFKAIAQLFILG--CS
WGL-GFFM-FEAVGETAGLVMAYMFTIINVLQGVLLFVVHCLLNRQVRL--IISFL-AIV
PKSY--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MGS----------RWLA---LLSAVSVL-------------------
-----------------LAS-----------SG-SEA-----QTSRDSCPPCPETAVCYN
S-THCVCRNGFKYSWLGRI-FHT-SY-LKCDDADE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------RSE-LAKCQ-EMFCSK-KIGYHLCVC-------VVQR-SFF-------------
-----HWL------SGS---------------------------------LDTEH-----
---------------------------AECHENE----------DGN-MN----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------SQ--QNAWEDLSKNK---------------S-
Q---KDFAEKATILLKQVELE-ILN-KNIDS---P-GKGENPLFD-----LVYETKRCRE
-------ETL-LE------A-----------------GNN---------TMDL---NCTG
AFKDT-------TGD-----KSIVALITYRSL-----GNFL-NGSFFRD--------RRR
-----KLG-----------------ARLNSQV-VSGTVGD-----KVN-LSEP-TFLT--
-----F-QHTQ------------------P-GG-ETAKHL-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WEGS--KDGGSWST
E-GCFHV-GSND-SHT-RCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VAL----S--PKED----LV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LTVITYVGLGLSLLCLLLAVLTFLLCRPIQNT-STTLHLQLSLCLF
LAHFLFL-TGINRTEP-------E---MLCS---IIAGVLHYLYLAAFFWMLLEGLHLFL
TVRNLKVANYTSS-GRFKKRFMYPLGYGIPAVIVTVSAIVGHQNYGTY---TH-CWLKL-
-D------EGFIWSFMGP----VALIIL--------------------------------
-----INLVLYFQILWIL-RSKLSSLNKEVST-I--QDT--RVMTFKAIAQLFVLG--CS
WGL-GFFM-VEEVGQTVGLVIAYLFTITNVLQGVLLFVVHCLLNRQVRM--EYKKWFSRV
QRGVE-TE-STEM-------SR-STTHTR-MEEPG-KSS-ELGH----------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TL-SDLS
S

PF07645 // ENSGT00900000140800_1_Domain_0 (302, 383)

DVDECT-SGQNSCHKSAQCHN-TEGSYECRCSPGWKP-VPGSP-NGPNN----------
--------------------TV

ENSGT00900000140800_1_Linker_0_1 (383, 391)

C-----ED

PF07645 // ENSGT00900000140800_1_Domain_1 (391, 448)

-V-----DECTSGQ-TSCHKSAQCHNTE-G
SYECRCSPGWKPIPGSPSGPN---NTV

ENSGT00900000140800_1_Linker_1_3 (448, 450)

CE

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 504)

DVDECTSGQNSCHKSAQCHNTEGSYECRC--
SPGWKPIPGSPNGPH-----NTVCEDVDECT-----------------------------
------------------------------------------------------------
--------SGQNSCHKSTQCHNTEGSYECRCRPGWKLVPGSPKGP-NNTICE

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 705)

DVDECTSG
QYSCHKSTRCHNTEGSYECRCSPGWKPVPG--SPNGP---NNTICEDVNECSSGQNSC--
---------------HK-----------------S-----------------------TQ
CHN----TEGSYECRCSLGWKPVPG-SPNGPNNTVCE

PF07645 // ENSGT00900000140800_1_Domain_10 (818, 870)

DVDECTSRQNSCHKSTQCHNTEG
S-YECRCSPGWKPVPGSPS---G-PHNTVCEDVDECTS---GQ-NSCHKS----------
----------------------------------------------------TQCHNTAG
SYECRCSPGWKRVPGSP-N-------------------------------G--PNNTICE
DVNECSSG--QNSCHKSTQCHN-TEGSYECRC-------SLGWKPVPGS--PNGP--NNT
VCEDVDECTS-------------------------------------------------G
QNSCHKSTQCHNTAGSY-ECRCSPGWKRV----P--GSPSGPHNTVC-E

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1259)

DVD-ECSSGQN
S----------CH--KSAQCHNTEGSYECRCS----PGW--KPILGSPNGPHNT-I--

ENSGT00900000140800_1_Linker_15_17 (1259, 1262)

C-
E

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1320)

DVDECTSGQNSCHKST--------QCHNTE---GSYECRCSPGWKPVPGSPSGPHNTV

ENSGT00900000140800_1_Linker_17_20 (1320, 1575)

C
EGLEFRSH------------------------------KYNIG-DGPWA-ASAGAYVERA
-------------------------------------------------ASGCFMAL---
----------------LFALLRDIL--PPM--GCARV---MVSEVSVIYS---FKGG---
-----------------FE-RRSRKDVSKDWREGL-IFS----LALSSDMSITSPVTVHP
SAQVGGWVRS-HRT

PF07645 // ENSGT00900000140800_1_Domain_20 (1575, 1613)

DVNECI-----------------LGKNCHKSTQCHNT-

ENSGT00900000140800_1_Linker_20_21 (1613, 1777)

K---TKWE
KIWGSC--NGW--GG-----AEKTGGFGAPLG-----SWVD-------VQ----------
--SLKYMGCF----SDNPLKIQEVSLVLLSDV-ISAFVSNT---DTQN-LSSP-VTFV--
-----F-KH------------------SVT-TG-PR

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKVF-CVF--WEPG-QNGSGHWST
K-GCWMV-GTGD-TST-TCQCSH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAH--YDV--QDDD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-PA---
--------------LAVITYVGLSLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------K---VLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLMVVSYSNV-SKFMKKFMFPVGYGVPAVIVAISAAFRPHLYGTPA---R-CWLHP-
-E------KGFIWGFLGP----VCAILF--------------------------------
-----VNLAFFLMTLCIL-KSKLSSLNSDVST-L--KNT--RMLTFKAIAQLFILG--CT
WCL-GILQ-VGP----AAHAMAYLFTIINSLQGVFIFLVYCLLSQQVRE--QYRKWLKRV
GKIKV-ESEQYTL-------SS-GLLSNA--RKHSVSTSLTD------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------ICPRNAKCVN
S-THCACLEGFLSRG-GRF-FND-TL-ETCDGNGDPRP---TP-DVPDTR-GERGLWVTS
VSQ-----GRESLSVGLGAAPLVQG-----------------------------------
----------------------------------------------------------AA

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DIDECLGPN-PVNCGPDAKCNN-LPGSFYCSC-------ADGYESSSGK--ARFPNASEN
SC------------------------------------------------RDIDECLWPP
GVT---------------------------------------------------------
-----------CG--PNANCTNLPGSFYCTCA----DGY--KTSSGKARFPNA-------
--IPSSHPLHGRLKLSV------------------NAGGRQSERGREG------------
------------------------------------------------------------
-------------------------------------EGELRGSSSGFC--S-FLNSTLR
ILKS---------ECGEGNATLSLEETTRS--FNSFLNRTSLG---------------S-
SRCEGEVASAVTVLLQSVERV-ALA-TALRSPGQATQNMRTES-------MAIETRVISE
NCSQHSEAFR-LS------S-----------------DGE---------TMEV---HCTT
VTHAA-------TQA---HLGAA-AFIAYSSL-----HSIF-NERLFSS--------GCL
SAGGMLEK-----------------SHLGSRV-VSGAVGDG---GPIC-LSRP-ANFT--
-----L-RHQQ------------------P-RK-EQEV

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1838)

AL-CVY--WKFE--AGKGSWSP
D-GCTTL-HVNS-THT-TCSCDH-LS----SF-AIL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAP---TA--VTES----RP---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LNILIYVGLSLSLLCLLLTILTFLLCRSIWNV-STALHLQLCLCLF
LADLLVL-SSQWKTNV-------S---VACA---VIAGLLHYLFLACFTWMLLEGLHLFL
TARTLKEVYYTSI-RRFKKRHMYPFGYGFPALIVAISAAVNPKGYGTS---EH-CWLSL-
-D------RGFRWSFLGP----VCVIIL--------------------------------
-----INVTFFALTLWIL-RSSLSSLNADVST-L--RGH--RLMIFKTIVQLFVLG--CT
WIL-GLLQ-VGP----AATLMAYWFNIINSLQGAFIFLVHCLLNRQVRE--EYRRWIRGF
RPPRK-KSQTDDL-------SM-STVPTT-GTKA--------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-INECAPPT-SVSCGKFADCQN-VEGSYYCMC-------SPGYELASGG--RMFRNKSEN
TCQ

PF07645 // ENSGT00900000140800_1_Domain_14 (1084, 1187)

DVDE-CQQ------------------------------------------------K
PRPCKSPGVCVNTRGSF-TCQCPLGFQLK----P--EDP-----KQC-TDVN-ECSLKRK
P----------CH--NTTHCLNTIGGYRCSCR----PGW--KPLPGSLNGPNDT-V--C-
EDKSNCSSGQH-CHSSS--------CCLYSE---DIHTCHCHQALAPEFGFQNNQTTTA-
--------------------------------------CEKMP-FTSWT-WSSGVNSQ--
-------------------------------------------------SLSRF--D---
----------------KVDLRRDYK--PDLANYXXXN---LTWLVDELLE---TPGDLE-
SLPTLDQHCVATSLLNNLE-NT-LRTLSKALPKGS-LTL---------------------
-HAPAGTDLS-LD--VME-Q-----------------RVRNVTLGQNSTKM-S---LGWD
TAKES----EN--SG-----LSVVGLVSFPGM-----GKLL-AG

PF00002 // ENSGT00900000140800_1_Domain_22 (1665, 2207)

AP--------------
--------LQ----KTRNDLLWGSSPILLSDV-SSAFLSNS---DTQK-LSSP-VTFI--
-----F-SHRP-VT-----------------LG-PGQKVL-CVF--WEHE-KGGCGHWAT
T-DCRMV-DTQE-TST-TCHCTH-LS----SF-AVL-MAH--NDA--QXXX----XX---
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXX-------X---VLCA---IIAGGLHYLYLAAFTWMLLEGLHLFL
TARNLTVVNYTSV-SRRMRKLMFPVGYGVPAMIVAISAACRPYLYRTSA---R-CWLDP-
-E------KGFIWAFLGP----VCTIFS--------------------------------
-----VNLALFLMTLRIL-KNKLSSLNSDVST-L--QNT--RMLTFKATAQLFILG--CT
WCL-GILQ-VGP----AAQVMAYLFTIINSLQGVFIFLVYCLLSQQVQE--QYRKWCIGI
RKLRD-ESEMYTL-------SS-RVMPDV--SKPSG------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------P------DGAVFISYKSL-----DSRL-SGSFLKLS--------E-
-DPEENYP-----------------AVVISQV-VTGSITRE---PTKN-LNPP-VTFY--
-----L-NNLQ------------------A-SN-SS

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QKYL-CVF--WDPE----LSGWSQ
R-GCNMT-HSNV-SHT-VCSCDH-LS----TF-AVI-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAP---CD--IKKD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-RG---
--------------LLFISRIGLGVSVLCLFLSLVTFLLCRSLRSA-HTSMLIALCGCLF
LGQLIIL-FGLPQTQF-------K---ILCS---IIAGCLHYILLCAFCWMTLESVLLFL
TVRNLNAMNYLTS-RRSHFPTACIIGFGVPAVIVAISAAVYSKAYGTG---KS-CWLSL-
---------NLIWSFLGP----VCVFIT--------------------------------
-----INTTLLILTFWLL-RVKLASLNTNVSS-L--KNT--RLLAFKALVQLFILG--ST
WIL-GFFQ-CGP----GAIVASYLFTICNSLQGAFIFLVHCLLNHQVRE--EYHKVFRRL
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MQGPPLLPGLCFLLS-L----SG-VLA-----QKSKGTCRQCPLNASCVN
G-TYCTCNPGYTSRSGQKF-FTF-PL-EICE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1082)

DVDE-----------CK------------
------------------------------------------------------------
------------------------------------------------------------
------PPI-SIYCGVNAECQN-IEGSFYCHC-------NAGYKLLSGN--AQFSNSNEN
TCQKTTSSKTTQGT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------K-------ELQQVVED--IESLLTNKTAW---------------V-
MEEKRDIASKATFILQTVESD-VIK-TALRAPDQKIQKIQNSTVA-------IETRVVTD
SCSK--GIIFNLM------A-----------------QMN---------SLSI---HCND
VIQGN-------TQG-----PSAVAFISYSSL-----GNII-NATFFEE--------TNE
-----KDP-----------------VYLNSQV-VSAAVGPE---RNVS-LSQT-VILS--
-----F-QHVK------------------M-KP-HI

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

KRTF-CVY--WKGT--KEGSHWSR
D-GCVLI-QANK-THT-TCNCTH-LS----SF-AVL-MAF---DS--QXXXXXXXXX---
--------------XXXXXXXXXXXXXXX----XXXXXXXXXXXXX-XXX---XXXXXXX
XXXXXXX-XXXXXXXX-------X---XXXXXXX

PF00002 // ENSGT00900000140800_1_Domain_22 (1955, 2130)

XXXXXXXXXYLAAFTWMLLEGLHLFL
TARNLTVVNYSGV-NRFMKWFMFPVGYGVPAVIVAISAASRPNLYGTP---DR-CWLHP-
-D------QGFIWGFLGP----VCAIIC--------------------------------
-----VNFIFFLLVLWIL-KRKLSSLNSEVST-I--QNI---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
FFWGCCVMHSWE--RHTGPTLKPT------------TKD

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 435)

NKCRDSTMCPSHAICTSTVDS
YYCA-CKQGFRSSNGQ--NHFKDPGVECKDDNECAN------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PRMCPEHATCNNTVGNYSCFCDPGFESSSG--HLSF----QGLKCE

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 855)

DIDECT--------
------------------------------------------------------------
----------------------------------------------EMCPINSTCTNTPG
S-YFCTCHPGFAPSNGQLN-FTD--QK--VECR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1322)

DIDECRQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFRPN--------PE--
-SSQK--DG-N-F-SCQR-V----------------------P-FK-C-------K-EDV
---IPDN--E-QV---QQCQERT--T---VKP--------EYVS---FC-----------
----------AQINNILSVLDKVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
NFTKEETSSLATVFLESVESLT-LA--TFLKPSA------NVTQTVRTDYLDIESKVINK
ECSEENVN-----------LSLAAK-------------GD---------KMKI---RCST
IEESE-------STG-----TTGVAFVSFVGV-----ESVL-NERFFQDH--------QA
PLTTSKIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-EFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-IHTV-CSCNR-MA----NL-AVI-MA-S--GE--LTMD----FS---
--------------LYVISHVGMIISLVCLVLAIATFLLCRSIRNH-ITYLHLHLCVCLL
LAKILFL-AGIDKTDN----------QMGCA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHICAFGYGLPVLVVVISASVQSQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIAVSKYDNSLAKCVLKEEQGDLRDLEFP----GT
CA

PF00002 // ENSGT00900000140800_1_Domain_22 (2103, 2196)

AERINSILLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNHQVRE--EYKRWITGK
MKPSS-QSQTSSI-------LLSSMPSTSKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWGFWLL--------------
LFWGFSGMYRWG--MTTLPTLGQTLG-----------GVNECQDTTTCPAYATCTDTTD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

S
YYCT-CKRGFLSSNGQ--TNFQGPGVECQDVNECLQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
DSPCGPNSVCTNILGRARCSCLSGFSSSTG--KDWILGSLDHFLCADVDECLT-IGICPK
YS------------------------NCS---NSVGSYSCT-------------------
--CQPG-------------FVLNGS---------ICE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DEDECVTRDVCPEHATCHNTLG
S-YYCTCNSGL

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ESSGGGPM-FQG--LDESCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECSR---NS-TLCGPTFICINTLGSY
SCSCPAGFSLPT--FQILGHPAD-------------------------------------
--------------------------------------------------------GNCT

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1067)

DIDE----C-DDTCPLNSSCTN-TIGSYFCTC-------HPGFASSNGQ--LNFIDLE--
-----------------------------------------------VTCE---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1324)

DIDECTQDPLQCGLNS--------VCTNVP---GSYICGCLPDFQMD--------PE--
-GSQG--HG-N-F-NCKR-I----------------------L-FK-C-------K-EDL
---IPQS--E-QI---QQCQAVQ--G---RDL--------GYAS---FC-----------
----------TLVNATVTILDNTCENKSAP--VSLQ---SAATSVSLVLE---QASTWF-
ELSKEETSTLGTILLETVESTM-LA--ALLIPSG------NASQTIQTEYLDIESKVINE
ECKE-NESIN-LA------A-----------------RGD---------KMNV---GCFI
IKESV-------STG-----TPGVAFVSFAHM-----ESVL-NERFFEDG--------QS
FR-----K---------------LR--MNSHV-VGGTVTGE---KKED-FSKP-IIYT--
-----L-QHI---Q---------------P-KQ-KSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WNTD-VEDG-RWTP
S-GCEIV-EASE-THTV-CSCNR-MA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGTVISLVCLALAIATFLLCRAVQNH-NTYMHLHLCVCLF
LAKILFL-TGIDKTDN----------QTACA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHLCAFGYGLPVLVVIISASVQPRSYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCMIIT--------------------------------
-----INSVLLAWTLWVL-RQKLCSVSSEVSK-L--KDT--RLLTFKAIAQIFILG--CS
WVL-GIFQ-IGP----LASIMAYLFTIINSLQGAFVFLIHCLLNRQVRD--EYKKLLTRK
TDLSS-HSQTSGI-------LLSSMPSTSKMG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------S----TY-CNY-F-----SL--EQVD---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2207)

-RG---
--------------LLYISRIGLGVSVLCLFLSLVTFLLCRSLRSA-HTSMLIALCGCLF
LGQLIIL-FGLPQTQF-------R---ILCS---IIAGCLHYILLCAFCWMTLESVLLFL
TVRNLNAMNYLTS-RRSHFPTACIIGFGVPAVIVAISAAVRYDGYGTG---KS-CWLSL-
---------NLIWSFLGP----VCVFIT--------------------------------
-----INTTLLVLTFWIL-RAKLASLNANVSS-L--KNT--RLLAFKALVQLFILG--ST
WIL-GFFQ-CGP----GAIVASYLFTICNSLQGAFIFLVHCLLNHQVRE--EYRKVFHRL
HVQKP-ES--EGV-------SG-STVPMT-LKSVS-LT----------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SPFCFPVPGLCFLLS-LSEV----MAQMTK---ATCPQCPQHAFCV----
------------------------------------------------------------
-----------------------------------------------------------H
GTYCTCDSGYASDSGKKFF-------------------------------T--FPLETCN
DIDECKPPI-SIYCGLNAACQN-VEGSFHCHC-------NPGYKLLSGG--TQFENSNAN
TCQK

PF16489 // ENSGT00900000140800_1_Domain_16 (1085, 1719)

TTSSKTTRDTEE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------LQR-------
-VVEKF----------------------------ESLLTND-TPWAMG------------
--------------------------------------------------EKREVASW-A
TTLFQTV--E------S----------------------------SV-------L-----
----------------ETAL-------KSP-EQKIQ----------KI------------
----------HNS-TVAIETLVVTD-------NCS-------------------------
---EEGKVFS-LN--TY-----------------------M-------NSVDI---RCND
IVQEN-------MKG-----PTAIAFISYSSL-----GNI--INATF-FE---------E
AN--GKDRVY-----------------LNSQV-VSAAI

ENSGT00900000140800_1_Linker_16_21 (1719, 1781)

GPE---RNTS-LPKS-VILS--
-----F-QHVK------------------M-KP-SSEKAV

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVY--WKST--NEGGQWSS
D-GCFLI-QANK-SHT-ICNSTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VAL---TH--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2021)

-LVVITYVGLGLSLLCLLLAALTFLLCKAIQNT-STSLHLQLSICLF
LAHLLFL-TAIDQTKI-------K---LLCA---IIAGALHYLYLASFTWMLLEGLHLFL
TARNLMVVNYSSV-SRLMKRLMFPVGYGVPALIVAISAASRPSLYGTPT-----------
------------------------------------------------------------
-----------------------------------------RMLTFKATAQLLILG--CT
WCL-GVLQ-VGP----AARVMAYLFTIINSLQGAFIFLVYCLLSQQ------VRKWFREI
MKSKP-ESETYTL-------ST-RFGTNS-RPRGD--V----FP----------------
-----------EQLKRKYSN----------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MRI----------FPPLSISALRVL----------------------
----------------------------MVWSV-VQL-----QNVSASCPQCSENADCYN
S-THCICKDGFWTGPDSRI-IIE-PH-VKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1065)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------QLG-IPVCKDVSYCKN-KIGTYICSC-------VVNY-RIF-------------
-----NWV------AGI---------------------------------VDIEN-----
---------------------------PECYD----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------ETAVALIAYQSL-----GKYL-NGSFFN---------KEG
-----IQE-----------------VKLNSLI-VSGAIHSE---VKPV-LSEP-VLLT--
-----L-QNTQ------------------P-ID-PRAEHI

PF01825 // ENSGT00900000140800_1_Domain_21 (1781, 1836)

-CVH--WEGS--EEGGSWST
K-GCSHM-HTND-SYT-TCKCFH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL---S---LEED-SVLSA---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2032)

-LSVITYVGLSLSLLCLFLAAVTFLLCRPIQNI-STTLHLQLSICLF
LADLLFL-TGINRTEP-------K---ILCS---LIAGMLHYLYLASFMWMFLEGLHLFL
TVRNLKVANYSSS-GRFKKRFMYPVGYGIPAFIVTVSAITGHENYGTH---T--------
------------------------------------------------------------
-----------------------------------------QVMTFKAIVQLFVLG--CS
WGI-GLFM-VFEFGKTVRLIIAYLFTIINVLQGVLIFVVHCLLNRQVRM--EYKKWFHKM
QKSAE-IE-STEM-------SY-STTHTK-MVSST-PKS-RYGLI---------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MYSDSILC------------
---------------------------------------------LF-A

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1251)

DIN-ECQ----
-----QN-AGICG--TKAECNNTMGGYKCTCD----SGY--QTKANKTEFCHNENYTKC-
EALCEIYLQER-------------------------------------------------
------------------------------------------------------------
------------------------------------------NKTLSFC--NQKRNISIK
L----LEICK-TLKSTYRLLESSCHDNENK---LDIEXIT---NSASGIL---SDPSWF-
NLSSSLVSTVVNGLLETVELL-VFK-SFHTNPSN--QNFSSPEM-------DVATKVAQE
NC-----SFLTIT------V-----------------GLN---------RMQV---SCDL
LPKPK----------------DGAVFISYKNL-----DSRL-SGSFLKLS--------E-
-DPEENYP-----------------AVVISQV-VTGGITSQ---IREN-LNPP-VNFY--
-----L-NNLQ------------------V-PD-SS

PF01825 // ENSGT00900000140800_1_Domain_21 (1777, 1838)

QISL-CVY--WDPK----LGGWSQ
R-GCNII-FSNI-SHT-VCSCDH-LS----TF-AVI-

ENSGT00900000140800_1_Linker_21_22 (1838, 1855)

MAP---CD--IKED---

PF00002 // ENSGT00900000140800_1_Domain_22 (1855, 2202)

-RG---
--------------LHSVSRIGLGVSVLCLFLSLVTFLLCRSLRSA-HTSMLVALCGCLF
LGQLIIL-FGLHQTQF-------R---ILCS---IIAGCLHYILLCAFCWMTLESVLLFL
TVRNLNAMNYLTS-RRSHFPTACIIGFGVPAVIVAISAAVRYDGYGTG---KS-CWLSL-
---------NLIWSFLGP----VCVFIT--------------------------------
-----INTTLLILTFWLL-RVKLASLNTNVSS-L--KNT--RLLAFKALVQLFILG--ST
WIL-GFFQ-CGP----GAIVASYLFTICNSLQGAFIFLVHCL------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MCLEDATCTHLPGG
HCCP-CKPGFASSSGE--QRVTDPAAQCN

PF07645 // ENSGT00900000140800_1_Domain_3 (450, 489)

DIDECSRDPSPCDPNSICSNMLGSYTCMC--
QAGYLPPSQ--------SGVRFSCTDIDECS-----------------------------
------------------------------------------------------------
--------RDPSPCGPDSICTNTPGSYTCSCREGYL-PPSQPG---APFRCT

PF07645 // ENSGT00900000140800_1_Domain_6 (653, 693)

DIDECSRD
PSPCGPNSICSNTPGSYTCMCRAGYLPPNG--SMYVCGMPFCFFCTNINECSRDPSPCGP
------------------------DSICT---NTPGSYTCR-------------------
--CRSG---------YLTPS----Q-PGA--PF-SC------PVPRLLCLENATCTRIPG
G-HCCPCKPGFASSSGEQR-VTD-PA-VQRN

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 911)

DIDECSR---DP-SPCGPNSTCSNTLGSY
TCMCQAGYLPPSK------SGTPFSCT-DI--------DECSRD-PSPCGPNSICSNTPG
SYTCRCQAGYVPPSKSG-------------------------------------VRFSCT
DIDECS-RD-PSPCGPDSICTN-TPGSYTCRC-------RAGYFPPSQP--GAPFSCT--
-----------------------------------------------DIDE----CSRDP
-SPCDPNSICSNMLGSY-TCMCQAGYLPPSQSG--------VR-FSC-T

PF07645 // ENSGT00900000140800_1_Domain_15 (1190, 1242)

DID-ECS----
-----QD-PSPCG--PDSICTNTLGSYTCRCR----SGS--

ENSGT00900000140800_1_Linker_15_17 (1242, 1262)

LPPSQP-----GA-PFSC-
T

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1306)

DIDECSQDPSLCSPNS--------ICTNTP---GNYTCMCQAGYLPPSQPGA-------
P-----------F-SCTEVTSK-----------------CRAH-FLDEN-----------
-------------------------D-----L-----VPSCHPAQAAYC--S--------
-----------LLKSTFRALAEPCKEKNST--VCLEK---AAGGFASVLE---QTSSWS-
NLSTEQLSVFATIVLHNVERI-VMD-ILTNPTENG-------NLTFHAEQLDVRTTLIGD
GCSREDSVIS-LR------A-----------------KGD---------TMEI---SCRM
VQGST-------AQG-----AAGVAFASYEGM-----ETIM-NGSFF-----------QG
QKATSGRT-----------------IQMISRV-VSAWLTSQ---TKIK-VTDP-VNYT--
-----F-QHIM------------------P-SN-CSE

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

KPV-CVS--WETT--AQGGSWSP
A-GCRIL-SSNA-THT-TCICNH-VS----SL-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAC---GE--IMAD----FL---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LFLITHVGLALSLLCLLLAILTFLLCRSIRNV-NTSIHLQLCLCLF
VADLLFL-TAVDRTRH-------Q---VGCA---VIAGFLHYLFLACFAWMFLEAVVLLL
TVRNLGVVNNFHT-HSPKIWFLSLFGYGFPTLVVAVSATLMPKAYSRQ---EN-CWLSM-
-E------RGFIWSFLGP----VCVIVG--------------------------------
-----INSILFAVTLWML-QRKLSSVTSNVST-L--KDT--RLLTFKAIAQVFILG--CT
WTF-GLLQ-TGP----TAVVMTYLFIILNSLQGVFIFLVHCLLNRQVQE--EYKRWFTSK
SKSYS------EV-------PM-STLATS-SQVVR-EQMA--------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MSLPSVPGLCFLLS-LSGA----EAQVAK---GPCNRCPLHGSCV----
------------------------------------------------------------
-----------------------------------------------------------N
STHCTCNPGFISGSGKQFF-------------------------------T--YPLEICK
DIDECKPPI-SIYCGLNAECKN-VEGSFHCRC-------IPGYALLSGD--VQFNNSNEN
TCQNITSSKTPNGHPE--------------------------------------------
------------------------------------------------------------
--------------------------------------------------

PF16489 // ENSGT00900000140800_1_Domain_16 (1251, 1719)

LQQ-------
-IVNNF----------------------------ESLLTNQ-TFWGAG------------
--------------------------------------------------SKQEVAST-A
SSILQNV--E------S----------------------------KV-------L-----
----------------ETAL-------RAP-GQKIQ----------KV------------
----------QNS-TVAVETRVVSD-------NCS-------------------------
---EEREAFR-LH--TQ-----------------------M-------NSMVI---HCID
VIQGR-------AQG-----PSAVAFVSYASL-----GNV--LNATF-FE---------K
AD--EKDPLY-----------------LNSQV-VSAAV

ENSGT00900000140800_1_Linker_16_21 (1719, 1782)

APR---RNSS-LSQS-VTLT--
-----F-QNLK------------------M-KP-SSRKAF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVY--WKIT--EAGGHWSR
D-GCFLT-QVNQ-SHT-VCNSTH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-VAF---TS--QDED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LDIITCVGLGVSLLCLVLAALTFLLCRAIQNT-STSLHLQLSLCLL
LAHLLFL-TAIDRTQP-------K---VLCA---VIAGALHYLYLAAFTWMLLEGLFLFL
TARNLTVVNYSSV-NKLMKWLRFPVGYGAPAVIVAISAAARPHLYGTPA---R-CWLRL-
-D------QGFIWGFLGP----VCAIIL--------------------------------
-----VNLVFFLSVLWLL-RKKLSSLNSEVST-I--QNT--RMLTLKATAQVLILG--CT
WCL-GVLQ-VGP----AGQVLAYLFTIINSLQGFFIFLVYCLLSQQVRK--QYRKWFSDV
TKSKS-KSEIQTL-------SS-RLGPDL-KLSE--------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MRGFNLL--------------
LFWGCCVMHSWE--RHIRPTRKPN------------TKG

PF07645 // ENSGT00900000140800_1_Domain_1 (400, 434)

NNCRDSTLCPAYATCTNTVDS
YYCT-CKRGFLSSNGQ--NHFKGPGVQCKDIDECSQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQPCGPNSSCKNLSGRYKCSCLHGFSSPTG--NDWVPGKPGNFSCTDINECLT-STVCPE
HS------------------------DCV---NSMGSYSCS-------------------
--CQVG-------------FISRNS---------TCE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 853)

DVDECADPRACPEHATCNNTVG
N-YSCFCNPGFESSSGHLS-FQG--LEASC------------------------------
------------------------------------------------------------
-----------------------------------------------------------E
DIDECT-----EMCPINSTCTN-TPG

PF12662 // ENSGT00900000140800_1_Domain_14 (1047, 1265)

SYFCTC-------HPGFAPSNGH--LNFTDQE--
-----------------------------------------------VECR---------
------------------------------------------------------------
------------------------------------------------------------
-DIDECHQDPSTCGPNS--------ICTNAL---GSYSCGCIAGFHPN--------PE--
-GSQK--DS-N-F-SCQR-V----------------------L-FK-C-------K-EDM
---IPDK--K-QI---QQCQEGT--A---VKP--------AYVS---FC-----------
----------AQINNIFSVLDKVCENKTTV--VSLK---NTTESFVPVLK---QISTWT-
KFTKEETSSLATVFLESVESMT-LA--SFWKPSA------NVTPAVRTEYLDIESKVINK
ECSEENVTLN-LV------A-----------------KGD---------KMKI---GCST
IEESE-------STE-----TTGVAFVSFVGM-----ESVL-NERFFQDH--------QA
PLTTSEIK---------------LK--MNSRV-VGGIMTGE---KKDG-FSDP-VIYT--
-----L-ENI---Q---------------P-KQ-KFER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VKGG-RWTS
F-GCVIL-EASE-TYTV-CSCNQ-MA----NL-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTMD----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LYIISHVGIIISLVCLVLAIATFLLCRSIRNH-NTYLHLHLCVCLL
SAKTLFL-AGIHKTDN----------KTGCA---IIAGFLHYLFLACFFWMLVEAVILFL
MVRNLKVVNYFSS-RNIKMLHICAVGYGLPMLVVVISASVQPQGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCTVIV--------------------------------
-----INSLLLTWTLWIL-RQRLSSVNAEVST-L--KDT--RLLTFKAFAQLFILG--CS
WVL-GIFQ-IGP----VAGVMAYLFTIINSLQGAFIFLIHCLLNGQVRE--EYKRWITGK
TKPSS-QSQTSRI-------LLSSMPSASKTG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------DFSPLLKLRLCFLLS-LSGD----VAQTPK---ATCPNCPSNASCV----
------------------------------------------------------------
-----------------------------------------------------------N
STHCTCNPGFVSGSKQTFF-------------------------------T--FPLETCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1075)

DVNECLPPF-SIHCGLNAECQN-TEGSFHCRC-------VPGYELPSGD--TEFKNLSEN
TCRSKKT-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------L-LQR-------
-IIDQF----------------------------ETLITNN-TLWQMG------------
--------------------------------------------------KKHEVAST-A
TSILRDV--E------L----------------------------DV-------L-----
----------------NTAL-------KAP-EQKVQ----------KV------------
----------QNS-TVAIETRVVTD-------NCP-------------------------
---EEKKTFS-LE--AQ-----------------------M-------NSLDI---HCHD
IVQGS-------MQG-----TCDSCLQDLSHR-----AVS--L-----------------
-----------------------------------IPRGQE---FETS-LSKS-KTQ---
-------QEDR------------------L-SP-------------------HGTRGYDR
D-LCF-------------------------------------PGW--QEED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LAVVTYVGLGLSLLCLLLAALTFLL---------TSLHLQLSLCLF
LAHLLFL-TAIDRTEP-------Q---ALCA---LVAGALHYLYLAAFAWMLLEGLHLCL
ALSNLTVANYSGT-NRLMKWLMFPVGYGVPAVIVAISAASHPHLYGTPD---R-CWLSL-
-D------QGFIWAFLGP----VCAVFC--------------------------------
-----VNLAFFLSVLWIL-KRKLSSLNSEVST-I--QNT--RMLTLKATFQLFILG--CT
WCL-GVLQ-VGP----AARVMAYLFTIINSLQGFFIFLVYCILSQQVNNGLSLCCFNEDS
---PL-SSEFGGL-------PR-ERGPDA-RPLTPNAWQQSEHS----------------
-------------VSTKIHQK---------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MWGFWLL--------------
LFWGFSGMHRWG--MTTLSTLVYSLN-----------GVNECQDTTTCPAYATCTDTAD

PF12662 // ENSGT00900000140800_1_Domain_2 (420, 453)

G
YYCT-CKRGFLSSNGQ--TNFQGPGVECQDINECLQS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
DSPCGPNSVCTNILGRARCSCLSGFSSSTG--KDWILGSSDHFLCA

PF07645 // ENSGT00900000140800_1_Domain_9 (707, 816)

DVDECLT-IGICPK
YS------------------------SCS---NSVGSYSCT-------------------
--CQPG-------------FVLNGS---------T

ENSGT00900000140800_1_Linker_9_10 (816, 819)

CE-

PF07645 // ENSGT00900000140800_1_Domain_10 (819, 852)

DEDECVTGNACPEYATCHNTLG
S-YYCMCNSGL

ENSGT00900000140800_1_Linker_10_11 (852, 872)

ESSGGGQV-FQG--LEESCE

PF07645 // ENSGT00900000140800_1_Domain_11 (872, 909)

DVDECSR---NS-TLCGPTFICINTLGSY
NCSCPAGFSLST--FQIFGHPVD-------------------------------------
--------------------------------------------------------GNCT
DIDE----C-DDTCPFNSSCTN-TIGSYFCTC-------NPGFASSNGR--LNFTDPE--
-----------------------------------------------VTCE---------
------------------------------------------------------------
------------------------------------------------------------
-

PF07645 // ENSGT00900000140800_1_Domain_17 (1262, 1324)

DIDECSQDPLQCGQNS--------VCTNVP---GSYICGCLPGFQMD--------PE--
-GSQG--HG-N-F-NCKR-I----------------------P-FK-C-------K-EDL
---IPQS--E-QI---QQCQAVQ--G---RDL--------DYAS---FC-----------
----------ALVNATFTVLDNTCENKSAP--VSLQ---SAATSVSLVLE---KAPTWF-
ELSKEETSTLGTILLETVESTM-LA--ALLIPSG------NASQTIQTEYLDIESKVINE
ECNEENVSIN-LE------A-----------------RGD---------KMNV---GCFI
IEESE-------STG-----APGVAFVSFAHM-----ESVL-NERFFEDG--------QS
FQ-----K---------------LR--MNSRV-VVGTVTGE---KKED-FSKP-IIYT--
-----L-QHI---Q---------------P-KQ-MSER

PF01825 // ENSGT00900000140800_1_Domain_21 (1779, 1836)

PI-CVS--WSTD-VEDG-RWTP
S-GCEIV-EASE-THTV-CSCNR-MA----NL-AI

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

I-MA-S--GE--LTME----FS---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2196)

-LFIISHVGTVISLVCLALAIATFVLCRAVQNH-NTYMHLHLCVCLF
LAKILFL-TGIDKTDN----------QTACA---IIAGFLHYLFLACFFWMLVEAVMLFL
MVRNLKVVNYFSS-RNIKMLHLCAFGYGLPVLVVVISASVQPWGYGMHN---R-CWLNT-
-E------TGFIWSFLGP----VCMIIT--------------------------------
-----INSVLLAWTLWVL-RQKLCSVSSEVST-L--KDT--RLLTFKAIAQIFILG--CS
WVL-GIFQ-TGP----LTRIMAYLFTIINSLQGAFIFLIHCLLNRQVRD--EYRKLLTRK
TDLSS-HSQTSGI-------LLSSMPSTSKMG----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MA-VSLEPK-SDLKQE-VFVTH-TDQDK-----------------------------
------------------------------------------------------------
--------TSS-VPGLAVVCI-MRN-------KNL-LLPGILM-LLLLTLG-AAAQYSR-
-DINMCERP---L----------------------------RKSCATYA-----------
---DCRSMDDKYCM----CGP-------------RQELIS-------------ETAFRN-
-E-----SENMCQ----GILVLLLL-TLGPAQKLKVSV---PTDCAQWCPPKSTCV----
------------------------------------------------------------
-----------------------------------------------------------N
ATACRCSPGFISSSGV-IF-------------------------------T--SLSESCD

PF07645 // ENSGT00900000140800_1_Domain_13 (1021, 1082)

DINECVPSS-TASCGKFADCWN-TVGSYYCTC-------IPGYKLASGA--RTFRNESEN
TCQVHNPERRPDDQ----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------DPEG--------CCVESKQNNTEAPPYTRGELGDEKGLPSRPNSSGR
H----------------------------R-------GRPGIF-FPTWT-PPHGIKSR--
-------------------------------------------------RLSHFFKR---
----------------FEDLGRNFI--PAFVQDTIQD---VVQGVDELLQ---TPEDLE-
ALPRSKQHYVATNLLAGLE-NV-LSNLSQALPNGT-LTF---------------------
-NASAGTDLS-LK--VRE-Q-----------------GDKTVILSHNQVTM-M---LNWD
VVHES----ED--SG-----PSVVGLVSIPGM-----AKLL-VEAPLVLE----------
--PEKKAVLH----GARKGV-------LLSDV-ISAFMNNK---DTQN-LSSP-ITFI--
-----F-SHHS-VT-----------------TG-PKQ

PF01825 // ENSGT00900000140800_1_Domain_21 (1778, 1838)

NVF-CVF--WEHS-LDGYGHWST
T-GCRIV-TTED-TST-TCQCTH-LS----SF-AVL-

ENSGT00900000140800_1_Linker_21_22 (1838, 1875)

MAH--YDV--QEKD----TW---
--------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1875, 2196)

LAVITYLGLGLSLLCLLLAALTFLLCKTIQNT-STSLHLQLSICLF
LAHLLFL-MAIDWTEI-------K---VLCA---IIAGALHYLYLASFTWMLLEGLNLFL
TARNLTVVNYSSV-SSIMKKFMFPVGYGVPAIIVAISAASRPHLYGTPT---R-CWLHT-
-N------KGFIWTFLGP----VCTIFS--------------------------------
-----INLVFFLMTFWIV-KNKLSSLNSEVST-L--QNT--RMLTFKATAQLLILG--CT
WCL-GILQ-VGP----AAHVMAYLFTIINGLQGVFIFLVYCILNQQVRE--QYKKWFKGV
GKTKA-ESEKYTL-------SS-RTMSDD--SKHSMENYNEQ-L----------------
-----------SLKNL------SLRK----------------------------------
------------------------------------------------------------
----------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MRIKCLS---LLLALS---------------------
--------------------------ILLAVSG-SEA-----QNSGAHCPPCPADALCHN
R-THCVCMDGFQSRSGRKY-FTG-TK-DKCE

PF07645 // ENSGT00900000140800_1_Domain_12 (872, 1052)

DIDE-----------C-------------
------------------------------------------------------------
------------------------------------------------------------
------KTG-QAKCKDKSFCKN-RIGSYICSC-------LISR--LL-------------
-----FWA------ARF---------------------------------IDMDR-----
---------------------------PECYENP----------AQK-TP-P-QE-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------NVWELLAE-------------------
NVSKKEIARWATKLLHHVEMT-IWN-QSFAS---P-GKGNNTELN-----IVYETKKCHE
-------KTF-LE------A-----------------GNN---------TMSI---NCAD
AFKGA-------REA-----VSTVALITYQSL-----GNTL-NGSFFNN--------SRG
-----KRG-----------------VKLNSRV-VSGTVGLQ---DKVY-LSEP-VSLT--
-----F-QHTQ------------------P-GV-ENAQHF-

PF01825 // ENSGT00900000140800_1_Domain_21 (1782, 1836)

CVF--WEGS--EEGGSWST
E-GCLHV-GSSD-SYT-TCKCHH-LS----SF-AV

ENSGT00900000140800_1_Linker_21_22 (1836, 1874)

L-MAL----S--PKED----PV---
-------------

PF00002 // ENSGT00900000140800_1_Domain_22 (1874, 2195)

-LKAITYGGLSLSLLCLVLAALTFVLCRPIQNT-GTTLHLHLALCLL
LAHCVFL-IGIKRTEP-------Q---ILCS---VTAGLLHYLYLAAFTWMLLEGLHLFL
TVRNLKVANYTSA-SRLQKRFMYPLGYGIPAAIVTVCAIVGHKNYGTS---TH-CWLRV-
-D------KGFLWGFLGP----VAVIIS--------------------------------
-----INFVFYFQVLWIL-RSKLSSLNKEVST-I--QDT--RVMTFKAIAQFFLLG--CS
WGL-GFFL-VEGVGETVGSVIAYLFTIINVLQGVLLFVVHCLLNHQVRM--EYKKWFGGV
WKGVG-TD-SADM-------SR-STTHTK-M-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------