Query Results 

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAPDSGKTL------GS---
--GPAAP--ALPPAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAESMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSVILRFLHRNRI
SSLVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLIRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDVSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTITDQLDTQYDASSLISSMASVSQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDEWKLQELRQFVKSRIGCSADDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARTEAEK-N
ILCAQGKKEA-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQII
WNFYSKLKQNPRKECICAQTLLLQLLQSCFSVLQEDTRAAP-EEKPPAQRSEE----MEA
AKALYAHFCD-------VVDRVDEDSVPMGILKQEVRNTLLNGAAIFFPDRQTRRSHLFT
MMKNISEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLSV
AARECELLMLSGAQGEVDSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKELAVDLIEKYVV
QFLASTRMILESFLSQYSGKTIVEKLCNSVFSMATRQLVIFLLDFCALDIPHCTLLREFS
TLTELLRKLCSDPEG-GLSKLDAEAWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QIGSNMAI
PQAKMASVLNSPLWKPVFRHQICPELELEASWPTCPHQDGKEVKNIPDDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSRGKIPLSEDFAQVYSLADGIRIWML------------EMKQKSLMNLGNEADEKH
GLE-AAEVNPESL--AKECIQKSLLLLKFLPTGESSKEHCHKLLTV-NENDHL--QPLDR
HQRKSSVVEDHFQASVSPTETS-SSTAGD---KSPGLDVHPK----------LPPSSGPP
ATEAF--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPLPTVKEKYPVLKDVMD
FIKDQSLSHDSVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWCEKIAQEDPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EDVDGEKLDPQAHSHATTLRSQCMQLAGDCLMKAHQGK--GLKALALLGILPEDGPTPE
---MQAMTVTVPACTSE------------E---------------------------GKR
-AIDQEM-RPLDYKQRN---KA-DESLL-VMKDPSCQTQIVDVAAD-ANLPS---ELPAA
ET--SEA-SSQKPIEEKAVTPNPEQVFAECSQKRILGLLAAMLPPMKSGP--TVPLIGLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFATGDN
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWQDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESS-----DSQAQLSQYSQHFACIASHLLQTS
MDSHCPEAVEATWILSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELEEQEE----EVEQPVSSPVEPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQRKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAMDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKDLNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPRHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCTQSDLCD-LALLKPLWQLFTHMEYALFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVMQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATS
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTPG----------
-PGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKRNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLVVMDTLVSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRAILESLLSQYGGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVR-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPRRNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-SHL--QPLNK
RQRTSSVVEEHFQASISPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKERYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSSPE
---DQALPVTVPTGASEEQLEKKAAQGAELSEAG----------------------NGKR
-AVYEEV-RPVDFKQRN---KAD-KGVS-LSKDPSCQTQISDSPADASP----PTGLPDA
ED--SEV-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSRAQLSQYSQHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISALAEHGDLQLDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDYFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPALCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

VAAAPDARDRDSMGNAPSQSSEDEAAAAGGEGW-GS-HQDWAADSGXXX------XX---
------------------------------XXXXP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALRN

ENSGT00890000139411_0_Linker_0_1 (185, 278)

SS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSECKEGVGVHASLILRFLHRNRL
SGAAVPCPMLDRCGNVCSMRSSVLKESLDQLLQREK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVASTDQS
YMPQQVTVAVGRSASDLQDVRDVHIPSNVTGYVTLLENANISQHYVQVNIKRCLSDGCDT
RIHGLRAVGFQRVKKSGLSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPSVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVARVLDSLCTVTDRLDAQYDASSLISSMASVRQSLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRVGCSADGLGEDDPVGW
FELEEEWDEADVKVQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPLRADAEL-H
VVCAHCRRDGDDSVCGATLLLKTLQFIQQLAHDL--VQQKESGIKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVWAQTLLLRLLQSCLPVLQRDGPAASEETKPPRQSPGG----AAA
AKELHTHLCD-------VVDRVDGDSAPMETLKQEVRNTLLNGAAVFFPDRQTRRSRLFA
MM-NVTEQERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKGDVADMNSSEVLAGMSTLLSV
AARECEMLVLTGAQGEAGSVLFSLFWAVQGSLLSWCYLQLKSTDSAARGRAADLIDQYVR
QVLARMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLIELLRQLCADLEG-TPNKLDGETWQQ-ESPVVLHTWTKESAHNYENNCHDVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWALDLQLLVSRLMGRLAAQCMALKSAH-QFGSDMAV
PPAKMASVLNSPLWKPVFRHQLSPELGFAASWPTPPRQDSKEVKDIPDDPCHHFLLEFAQ
SDPAQTFCGPFSELFKGFIQACRKQAPKTDIVAGSTIDRAVNAAFAALVCRTPGLYEKLQ
THVKSGGSTALSEEFAQVYCLADGIRIWML------------EMKQKSLMNMGTEKEEKH
GSG-AAEVNPESL--AKECIQKSLLLLRFSPVGVSSKESRDRLAGA-DDTDHL--QSQDK
RPRTSSVLEEHFQASVSPGEAGAP-AAGN---GGPGSDTRLK----------LPPGSSPP
ATELSSATTEEPSSPSAPARRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDVLD
FIKDQSLSHESVVKVLALRKAQAQSVLEVLRVIQYCTEALGQPHCFHPPCILFLLELLTC
QKDFTNYFSHLEGCGAHLHREIRDTYYQFVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPHLLMKMSQENISVHDSVISQWSEEDELANAKQNSE
WMDECQDGMFEAWYEKIGQEDAEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VSMEFTCDHCQGLIVGRRMNCNVCEDFDLCY
GCYAAKKYSYGHLPTHSVTAHPMVTVRISDRQRLIQPYVHNYAWLLFAALALYSAHLASA
-EDVDGEKLDPRDRSSASTLRSQCMQLVGDCLMQAHQGK--GLKALALLGILPDGDSGPE
---SRAPPDSVPACPLREER---AVQGAEDL--NS--FT--------------FCFQDKR
-DGPKEV-GPLDSKPRS---KANEDGVS-SMKGPACQTPSSDSPAD-GGA---PTGHPDA
EN--TVV-LSQKPIEERAVTPSPEQVFAECSQKRILGLLAAMLPPIKLDP--TVPVIHLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLITRLSPAEVDAAVVQVLSAKHTLFASGDG
-SVVPDGWKTAHLLFSLGAVCLD---SRVGLDWACSMAEILRSLSSAPLWRDVIAAFTDH
CVKQLPFQ--LRHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHSVIILKHFTEKN
RAVIVDVQTRKRK-TVKDYQLVQKG--QEGS-----SSQAQLSQYSQHFAFIASHLLQTS
VDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLPTDLLKLLVTRCSKGTGFSK
TWLLRDLEILSIMLYSSKKEIHTLAEHTAPERDERGDQEEEV-EGTVSSPGEPEQRKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQKSRFDGDELTT
DERIRTLAQRWQPSRSLRLEEQGAKAVDTDMIILPCLSRPARCEQATAESNPVAQKLIAS
TESELQHSYAKQRRSQSAALLHKELNCKS-------KR-AVREYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDTLELSGPAHMTYILDMFMQLEEKQQWEKILRNVLQGCHGSMLG
AMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSVKFDSQCSTEEGCDE
LAMSSSSDFQQDRHTFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEDRVVPHLPLGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIARCCTHSDLCD-LALLKPLWQLFSHMEYSLFEDVTQPGIL-PPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------KKISQAFWWAPV
IP------AT------------------------------REAEVVPLHSCLVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFVDIFSESKEALGVHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSDVLGSHKHFWFRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSADFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLLLSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFYAEEHFKRFAKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCVHCRKDTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEKEKAPTQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKEEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLANMNISEVLAVMNTLLSV
AARECELLMLSGAPGEAGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDTAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTGLLKKLCGDPEG-GLTKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPHRDSKEVKNIPDDPCRHFLLEFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVHSGGRIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEGKR
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGMSSQESCDKLVTADET-NHL--QPLDK
RQRTGSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPR----------LLPSSGLP
VTDVSPAAAEEPVSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSIVKVLALRKAQAQGILEVLKITQYCAESLGQPHCFQPPFILFLLELLTC
QKDFTNYFGHLEGCGANLHKEIRDTYYQLVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAGA
-EDVDGEKLDPQTRSSAAALRSQCMQLVGDCLMKAHQGK--GLKALALLGILP------E
---DQALPATVPTQASEEQLEKKAVQGAERSEAG--PSV--------------HC-NGRR
-AVHEEV-RPVDFKQRD---KAD-KGVS-LMKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPTEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-STVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLDSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMSALAEHGDLESDERGDREEEE-ERPASSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQQWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
PMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLLEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCATQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QAFAQFDAEGDGAVDVEGMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSEPTERRAVHASLILRFLHRNRI
SSTAIPYPVLEHCNNICTMRSSVLRDSLDQLAQKEK-ECPGDPRGSQESDKL-KSVAKCY
TYIETSSNSA

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 426)

DIDKMTNGETSSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNSGSLQEVRDVHIPSNVTGYVTLLENANISQPYVQINIKRCLSDGCDT
RIHGL

ENSGT00890000139411_0_Linker_1_2 (426, 1903)

RAVGFQRIKKVGVSVSDASAIWYWSL---LTSLVTASMET------NPVFV---Q
TILHNTQKALQHMPPLSLSPGSADFSNFLSPNVLEEVDSFLVRITSCCATPDVELTLLAF
ALARGSIAKVMSSLCTISGHLDAQFKASSLISSMATVRQNLLYKY---GKPLQLTLQACD
VKGKEDKSGPENLLAEPWTGD-GFLTETGKTRASAIFSTGTGSPFQVTQIRIKVRRGGIG
AQCGLVFAYNCP-AERFHAEEHFKRFAKYDTWKLHQFRQFLKDSRSGGLSELGEDEPVGW
FELEEEWDEVDAKMQQCRIAKYLMVKFLCPRQENAERLGVQGLSLFGYLRPETLEPEP-G
ANCAHCRQDGEGTVCGATLLLKTLCFVQQLAQDL--VQQKERGLKYRSFLDFSGLDWQLF
WDFYKALKENPREECASAQTVLLQLLQSCFSVLTGDSQTTGAQAQGA-AASSEKSDGAQA
AQELYRHLCG-------VVDSVGDDPAPTETLRQEIWNTLLHGAALFFPDRHARRSQLFA
MMKDITEQERKQSVPLTFRSLCTYFSDRDPSGLLLLPEKGSEAEPDVGQVLEVMDTLQRV
AARECELLLQAGASRESGSALSSLFWSVQGNLLSWCYLQLQASDAGARELAGDIIRKYVS
QFLSSVRAILGSLLSRHGGQTVVEKLCNSVFAMATRQLVIFLLDFYTLDIPHWALLQEFS
TLTDLLKKLGSELGG-SPHKVDLEAWQQ-EQPVVLRTWTVESPHNYENNCHEVSVFVSPG
ATYFEVEFDDKCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFSVTAFGLPDVAVSWGLDLQLLICRLMGRLGSRCLALRSPP-EPGGQPEP
SPAKVAAVLNSPLWTPVFRHRLGAE--VGADQPPRRLSESQEAKDFPTDACRNFLLRFAK
SDPAQGFCGQSSELFKGLTQACKKQAPKTDIVAGSTVDRAVNSTFAALVYLTPDLYGKLQ
KYVNSGGQVPLDEDFTQVYSLADGIRLWML------------EMKQRSLSSQGLEEEEKP
GAE-MGEVNPKSL--AKQCVQKSLLLLRFAPPGPKMEDAADETSEVPEEQGRPRPPTPCP
WPGPGPVVEEHFRASEGPGEP--SRPP----------DPAARKKPGGSLSPAPAPASAPP
DRPAAQPEDAPPSPPSTPTRRAQLGRGRLRLLSFRSL--EEPKPAPTVKEKYPILKSILD
FVKDQSLSHESVLQVLSLRRAQAQRVRDVLQTVRLCLEQLAQPHCFHPPCVLFLLELLAC
QKDFAGYFGHLEGCGAELLQEIRDSFYQLVLFLVNAVRGFGGLND---RSLLPALSCVQT
SLL-HLLDMGWEPGDLEFFVTIQLPSLLLTMAQENISVHDSGICQWSEEDEMADYEQNRE
WMDGCQDGMFEAWYEKISQADPEKQRRMHMFIARYCNLLKVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPEGH

ENSGT00890000139411_0_Linker_2_3 (1944, 1952)

EDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEYACDQCRGVIVGRRVNCTVCDDFDLCY
GCYSAKRYSDSHLPSHNVTVLPMVTVRISDRQGLIQPYVHNYSWLLFAALALYSADLAGP
-QDGDGERLDPKVARQAAVLRCQCIQLVGDCLLKAQHGR--SLKALALLCPLPENERVSG
SS---SADSSTVALGEPPKKKAAE-----ARAPGGGTDLSGPWSGSRVSGVSLSSLEHGG
HPSLGM-------------------GGL---GEGTEPRLENGLLESPGVGNHLPPSLPPQ
GFKPHPQVGSRSLTGAKPVIPTPEQVFADCSQKRILGLLAAMLPPLKPARGCRGGSVQRK
PLWPEAFVIEPKASGFSPRSP-----RMGSQAERFILSPAKRPVGHLGSPEHLVAS----
----SGHWEACA------------------------PAQFVSQLVRQSVVSVERVLCAEH
CANTVELVGTIPAHNELTVPIPPEIP---TPVKMTKCPHQLDR-NHSHSFASLLSPSPPP
QP-----VVVPRP-AVKDYQLVQQSGREGPGDPGGRALCPQLERHLEHLAFITSHLLQTG
LDPGFAEAVEATWVLSLALKGLYKTLQSHGFEE-SRAAFVRSGLLKLLVKKCSKGTGFSK
TWLLRDLEILAITLYSSKKEMGSVAQRDDLALERDAGSEA-----ESAATSPVDRGKLDP
LEGLDEAT---KICLLMTH-DALNAPLHVLRTVYELQMSRTDPSFPEAQK-RFDNDGIPT
EEQLRSLARTWQPGPR--PEEQSSKALDTDMIILPCLSEPGPCDKAAAELTPATQKLITN
TEGDLQLAYAKQRRSKSSALLHKELDSRC-------K-RPARPYLYRVNEATAVLYARHV
LASLLADWPDHVPLGEETLDLSGAAHMTYILDTLMQLEEKQLWEKILRKVLRVCDTSMLG
TMALTACQFMEEPGMAVQVRESKHPYNNNTNFEGGRESQSAF------SGQEETLGGEQG
-IGDQNSELE---ESMAAR----------------------------------------A
LSWI--------------------PPLLCPALNPQPHPRLDSFWEWQVGVALPAQTGHQR
LKAVHLL-RIVQCGTRSDLCD-LTLLKPLWQLFTQMENSLGQDGTRPGTL-LPLHRALTE
-LFFVTENRVQHNTALSTLEAPMTALCTLEVARTAPCPLQALKNIAAISLAINYPNKTTS
FWT---

------------MGNVTSHSSEDEAAAAGGEGW-GP-HQDWAADSGTTP-----------
GPGLPAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHASMILRFLHRNRI
SSMVIPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVAKCY
AYIETSSNPTDVDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANISQPYVQINVKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKAGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVTKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVMIHYV--------------
------------------------------------------------------------
-TCLHCGQPQVFSL---IQPLGNLSLPNLSPPIP--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVCAQTLLLQLLQSCFSVLQGDALAASEEEKAPAQSPKG----VEA
AKELYTHLCD-------VVDRVGGDSVPVEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLADMNISEVLAVMNTLLSV
AARECELLMLNGAQGEAGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCMLDISHCTLLREFS
ALTEQLKKLCGDPAG-ELNKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAR-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPHQDTKEVKNIPDDPCRHFLLDFAQ
SQPAQNFCGPYSELCKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKR
GSE-AAEANPESL--AKECIQKSLLLLKFLPTGISSKESCEKSVTADET-DHL--QPLDK
RQRTSSVVEEHFQASASPTEAAPS-ATGD---RSPGVDVQPK----------LLPSSGPP
AAEVSSATTEEPLSPSTPSRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGAELHKAIRDAYYQLVLFLVKAIKGFSSISD---RSLLPALSCVQT
TLL-HLLDMGWEPGDLTFFVDIQLPELLMKMSQENISVHDSAISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLEPQARSSATTLQSQCMQLVGDCLMKAHQGK--GLKALALLGILPEGDSTPE
---NQALPVTVPTQTSEEQLKKKVAQDAEALSE-VGPF---------------------K
-AVHVEV-RPLDYKQRK---KAD-EGMS-LMKDPSCQTQISGSPADASP----PTELPDP
EN--SEA-SSQKPIEEKAVTASPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLILRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SSVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQEGS-----DSQAQLSQYSQHFAVIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHDFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDEQGDPEEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSVKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYARQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCQENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVAENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AFAQFDAEGDGTVDAENMLE
ALKSSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKESLGTHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLVRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQQYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLVRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTRYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SAKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILCAHCRKDT-ENICGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQSDPPVASEEEKPAAECPER----MQA
AQELYTRICD-------VVDRADGDSMPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFT
MMKNVTEHEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLANTNTSEVLAVMNTLLSV
AARECELLMLSRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTDTTAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRFDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSV--KLGSNMVV
SQAKLASVLNSPLWKPVFRHQICPEVELEASWPTHPQHNRKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKITLSEEFSQVYSLADGIRIWMVSLIVWLLSSPQLEMKQRSLLSLGSETEEKR
GLE-AVEVNPESL--AKECIQKSLLLLKFLPTSKSSKENGDKLVPVVDEPDHL--QPLDR
RQRTSSVVEEHFQASASPTEAA-TPTTGD---KSPGLEIQPK----------LPPSSGSP
GAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVXX--XXKAQAQSILEVLRIIQYCTESLGQPHCFHPPCILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EHVDGEQLDPQARSNAAVLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPK--------------TVQLAEEPADVG--LF--------------VTCNKNR
-ATDKEV-RPLDYKQRK---TA-TEGLS-LTKDLSCQTQTSDAPAS-A---PVPPGPPDA
EH--PEV-SSQTPVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIQSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDTAVVKVLSAKHNLFATADN
-GIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQAQLSQYSQHFAFIATHLLQTS
MDSHCSEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTEHGDLELDERGDQEEE-VDRPGGIPGESEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPVRSDQATAESNPVTQKLIPS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDFLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCREGMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNTSSNSSEDEAAAAGGEGW-GP-HQDWAADSGTTL------GP---
--GPAAA--ALPPAAALLEPVRLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALRNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLSVHSSMILRFLHRNRI
SSTVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEIDKLTKSVTKCY
AYIETSSNPA

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 428)

DIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVASTDQS
YMPQQVTVAVGRNANDLQEVRDVHIPSNVTGYVTLLENANITQLYVQINIKRCLSDGCDT
RIHGLRA

ENSGT00890000139411_0_Linker_1_2 (428, 1903)

IGFQRIKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPFSLSPGSADFSTFLSPNVLEEVDSFLLRITSCCSTPEVELTLLAF
ALARGSVAKVMKSLCTITDHLDTQYEASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKNRASTIFSTGTDSAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQETADRLGVQGLSISGYLRPARVETEQ-N
ILCTHCRKDS-ENVCGATLLLKTLQFIQQLAHDL--VQQKESGLKCKSFLDFTGLDLQIF
WKFYSKLKQNPREECIYAQTLLLQLLQSCFSVLQEDAPAAS-EEKSTAQHSEG----VQA
AKELYTHLCD-------VVDRADGESMPMEILKQEIRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTHFSDKDPGGLLLLPEKSDLTNTNISEVLAVMNTLLSV
ATRECELLMLSGAHGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSAAKELATDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAPRQLVIFLLDFCTLDISHCTLLREFS
ALTELLKRLCSDPEG-GLNKLDVETWQQ-EQPVVLHSWTKESSHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSYMAM
PQAKMTSVLNSPLWKPIFRHQICPELELEASWPTHPYQDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KY------------------------GWLL------------RFKQKSLMSLGSEAEDKH
CLE-VAEVNPESL--AKECIQKSLLLLKFLPTGKSSNEKCDKVVTA-DEIGHL--QPLDT
CQRTSSIAEEHFQASTSPTEAK-LLTVGE---KSSGLEIQPK----------LPTSSGLP
ATELS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEAKPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLKKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGVDLHKEIRDTYYQLVLFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAEKKYSSCHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFASLALYSAHLTST
-EDVDGERLDPQTHSSAATLRSQCMQLVGDCLMKAHQGK--SLKALALLGILPDSDSTSE
---NQALPAMTPTQSSEE------------QTVTR--LL--------------RPCSGKG
-AADTEV-RPLDDKQRE---EA-GEGFS-LMRSPSCQTQTSDAPAN-AQMRP---GLPDA
EN--SEV-SSQEPIKEKAITPNPEQVFAECSQKRILGLLAAMLPPIKMGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVIKVLSAKHNLFTAGDS
-AIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFH--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQEYG-----NSQAQLSQYSQHFAFIASHLLQAS
MDSHCPEAVEATWVLSLALKGLYRTLKAHNFEE-MHATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLDEHGDLELDERGDQEEEA-ERPISSPGEQEQKKLDP
LEGLDEPT---RVCFLIAH-DALNAPLHILRAVYEQQMKKTDSFFLEVQK-RFESDELTT
DEKICSLAQKWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AIRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSVKFDPQCNTEEGCDE
LTMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEEKVIPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVLCCTHSDLCD-LALLKPLWQLFTYMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATH
LWNVEC

------------MGNAPSNSSEDEAAATGGEGW-SP-HQDWAADSGMTP------GS---
--GPVAP--ALPPAAALLEPARLREAAAALRPAPP-------CETLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAESMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKESLGAHSSMILRFLHRNRI
SSTMIPYPMLDHCNNMCTMRSSVLKESLDQLVQKER-ESPGDLIRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLVRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCAIMDQLDTQYDASSLISSMASVSQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLRELRQFVKSRIGCSADDLGEDDPVGW
FELEDEWDEADVKLQQCRVAQYLMVKFLCTRQESAERLGVQGVSISGYLRPTRTEAEK-N
FLCTQCRKEA-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPRKECICAQTLLLQLLQSCFSVLQGDALSAP-EEKPPARCPEE----VEA
AKALYTHLCD-------VVDRQDGDFVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVSEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLAV
AARECELLMLSGARGEAGSVLFSLFWSVQGSLLSWCYLQLKSSDSAAKELAVDLMEKYVV
QFLASTRVILESFLSQYSGKTIVEKLCNSVFSMATRQLVIFLLDFCTLDIPHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVEAWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKEGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QIGSNVAI
PQAKMASVLSSPLWKPVFRHQICPGLELEASWPTRPHQDGKEVKNIPEDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSRGKVPLSEDFAQVYSLADGIRIWML------------EMKQKSLMNLGSEAEEKH
GLE-AAEASPESL--AKECIQKSLLLLKFLPLGKSSKEPCDKLVTA-EENDHL--QPLDR
RQRTSSVVEDHFQASVSPTEAS-PSTAGD---KSPGLDMLPP----------LPPVSGPP
AAEGL--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLSC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFIDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMEECQDGMFEAWCEKIAQEEPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDIDGEKLDPQARSHATTLRSQCMQLAGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---MQALAVTAPTCASEELLEKRVVQLVVEPAEAG--PI--------------VHCHGKR
-TIDEEI-RPLEYKQKN---KA-DDNLL-IMKDPSCQTHIVDASAD-VNLPS---GLSVA
EN--SEA-SSQKPIEEKAITLNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIGLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVVKVLSAKHSLFAAGES
-AALPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWQDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESG-----DSQAQLSQYSQHFACIASHLLQTS
LDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEIHTLAEHGDLELNEQEE----EVEQPASSPGESEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQRKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAVDTDMIILPCLSRPARCEQATAESSPVTQKLIAN
TESELQQSYAKQRRSKSAALLHKELNCKG-------KR-AVREYLFRVNEATAVLYARHV
LASLLAEWPGHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESQHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLARVWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTQSDLCD-LVLLKPLWQLFTHMEYALFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVMQDYLLAL-----TTDDHLLRCTAQALQNIAAISLAIGYPNKATR
LWNVEC

------------CRNAPCN----------------------ICLRGSSE-----------
SPASASQ---GAETTGTHHCAQLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVTKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCPLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAL
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKECIEKSLLLLKFLPTGIRSKESCDKLETADDT-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFPRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVLD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQALPVTAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPADFKQRS---KAD-KGVS-LTKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
---------------------------SGARPPHR-------CEERGDTK---AGEWMNE
RTNECTSERRRGESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELGHIIRQLQACSLVPGFIDIFSESKEGLGVHASLILRFLHRNRL
SGMAVPCPMLDHCNNMCSMRVSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-

PF03256 // ENSGT00890000139411_0_Domain_1 (294, 429)

KSVAKCY
AYIETSSNPADIDKMTNGDTASYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSVGELQDVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1902)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCAITDHLDTRYEASSLISSMASVRQNLLLKY---GKPLQLILQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SEKFHAEEHFKRFEKYDKWKLQEFRQFVKSRAGCSPGDLGEEDPVGW
FELEEEWDEADVKLQQCRVAQYLMVKFLCTRQESAERLGVQGLSISGHLRPARTGAEQ-H
VVCTRCVKDTEDSVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLRLLQSCFSVLRSDGPAASQDAKAPRQSPAG----AGA
AKELHTHLCD-------VVDRLDGDSVPMETLKQEVKNTLLNGAAIFFPDRQTRRDHLFA
MMVSVVT------------DLC-PFSDKDPGGLLLLPEKGDVASMNSSDVLAVMSVLLSV
AARECELLVLSGAQGEAGSVLFSLFWAVQGSLLSWCYLQLKSTHSGARELAADLLDQYVA
QFLASLRVILESLLSQYSGKTLVEKLCNSVFSMAARQLVIFLLDFCTLDISHCVLLREFS
TLPELLKQLCGDPEG-GPNTLDVEPWPQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATCFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWASDLQLLVSRLLGRLAAQCMALKSTH-KLGGDVAV
PPAKMAAVLNSPLWKPVFRHQLCLELGLAASWPTSPRQDSKEVTCIPEDPCRRLLLEFVQ
ADPAQSCCGPLSELCKGLIQACRKQAPKTDRVAGSTIDQAVNATFAALVCRTPDLYEKLQ
KYVKSGGHTALSEEFAQVYYLADGIRIWML------------EMKQKSLMSLGSEAEGRH
GSE-AAELNPESL--AKECIQKSLLLLRFLPMGVSSEESRDKLAAT-DDVDHL--QPRDR
RPRTSSVVEEHFQASLSPVEAATP-AVRD---GGPGSEAQPH----------LPPRVPPA
-------APEEPSSPSAPTRRPPFTRGRLRLLSFRSV--EEARPAPTVKEKYPLLRDVLD
FIKDQSLSHESVVKVLSWRKAQAQSVLEVLRIVQYCAESLGQPHCFQPPCILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIQLPDLLMKMTQENISVHDSVISQWSEDDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYSELLHV

PF00569 // ENSGT00890000139411_0_Domain_2 (1902, 1934)

DISCDGCDEIAPWHRYRCL
QCSDMDLCTTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1951)

G--GVKPEGHGDDHEMV

PF00569 // ENSGT00890000139411_0_Domain_3 (1951, 1993)

SMEFTCDQCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSVTAHPMVTIRISDRQRLIQPYIHNYAWLLFAALALYSTHLASA
-EDAGGERLDSRARSSAAALHSQCMQLVGDCLMKAHQGK--GDCHSNL------------
---------------------------------HS--FA--------------FCFQGKR
-DGH-KV-RPFDCKQRS---KED-EGAS-LMKDPARQTQVSDSP----------AGLPDA
DT--SVV-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKLDP--AVPVIDLE
RALPLMFQVVISNAGHLNETYHLTLGLLGQLITRLLPAEVDAAVVKVLSAKHTLFAAGDS
-SVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLSGAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGIP---QVLCVGTRCVYVDNANEPHDVIILKHFTEKN
RAVVVDVKTRKRK-TVKDYQLVQKG--QECN-----DCQAQLSQYSQHFAFIASHLLQTS
MESHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEIHTSVEHTGLEPDERGDQGEDT-EGAVSSPGEQEQRKLDP
LESLDEPT---RICFLMAH-DALNAPLHVLRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TEGELQQSYAQQRRSKSAALLHKELGCKS-------RR-AVREYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEETLELSGPAHMTYILDMFMQLEEKHQWEKILRKVLQGCRGSMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDAQCSTEEGCDE
LAMSSSSDFQQDRHTFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAQIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFLVTENRAQELGLLQEYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVKC

--------------------------------------------XXXXX-----------
XXXXXXX--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECIAAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPVEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSSDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEANPESL--AKECIEKSLLLLKFLPTGVRSKESCDKLETADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDE-----
---DQALPVTAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPIDFKQRN---KAD-KGVS-LTKGPSCQTQISDSPADAST----PTGLPDA
QD--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QAFAQFDAEGDGTVDVENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRI
SSTAIPYPVLEYFNNICMMRSSVLKDSLDRLLLKER-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

EYPSDLNGNEESDKL-KSVTKCY
THIETSSNSADIDKMTNGETTSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVAVGRNASSLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLRAVGYQRVKKVGVSVCDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---H
TILQNTQKALQHMPPLSLTPSSTDFSSFLSPNVLQEVDSFLIRITSCCTTPDVELTLLAF
ALARGSVAKVISSLCTITDHLDTPYKASSLIASMATVRQNLLYKY---GKPLRLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASIILSTGTESSFQVTQIRIKVRRGAIG
AQCGLVFAYNSA-SEKFHAEEHFKRFESYDKWKLKEFKQFLKNRSSCSSDELGDDDPIGW
FEVEEEWDEVDVRMQQCRVAQYLMIKFLCTRQDTAERLGVQGLNVLGYLRPMREEPSR-S
MHCLQCRRTDDETVCGTTLLLKTLHFIQQLAQDL--VQQKESGLKCKSYLDFTELDLQLF
WNFYNKLHQNPREECIFAQTLLLQLLQSCFSVLTGDNKTSKPQETLQ----SKTPGHTKA
AEDLYRHLCE-----GAVVDMEDTNFMPVKMLKQEVKNTLLSGAAIFFPDRQTRRNQLFA
MMKNITEQEHKQSVHLAFRSLCTHFSDQDPGGLLLLPEKGVSANFDISEVLSVMDTLLLV
AARECEMMMLDVAQQESGTVLSSLFWSVQGSLLSWCYLQLKGSDSSAKDLAIEILKNYVG
QFLTNIRMILQSLLSQYSGKTIVEKISNSVFAMATRQLVIFLLDFCTLDIPYCTLLQEFS
TLVEPLKKLCSEPHK-----MEIESWQQ-EQPVVLRTWTVESPHNYENNCHEVSVFLCHG
ATYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVCRLMGRLASRSMALKSLR-ELGSEADL
PPLKVTSVLNSPLWKPVFRHQMCPEAEPGASETSRGRQDKKEARSSHQDDCRNFLIDFAK
SDPAQDFSGQKSELFKGLVQTCRKQTPKTDTVAGSTVDRAVNSTFAALVYLTPALYEKLQ
KYVNSGGKVPLSDDFAQVYSLADSIRIWML------------EMKQKSLMGRGNDTEEKQ
STE-ASEVNPETL--AKLCMQKSLLLLNFLPVRAKTKGSTSDNLESQDGGN-VHQSVIDK
NQRKSSLVETDFQAAHSSSSNGVTRSVSVEGEQTTQSDK------------EASAFHSKP
SENAASQQEDVSSPPSTPTRKSQFSRGRLRLLSFRSM--EEPRAVPTLKEKYPILKNILD
FIKDQSLSHESVLKVLALRKSQGQNILEVLRTIRRCLDSLGQPHCFHPPCVLFLLELLAC
QKDFTNYFGNLEGCGAVLHKEIRESYYQLVLFLVNSVKGFSAIND---RSLLPALSCVQT
TLL-HLLDMSWEPSDLSFFVEIQLPQLLMTTSQENISIHDSVICQWSEEDEIADYKQNCE
WMDECQDIMFESWYEKIAQADPEKQRKMHMFVARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1945)

LNVDISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPEGHE

ENSGT00890000139411_0_Linker_2_3 (1945, 1950)

DDHEM

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEYACDHCQGVIIGRRMNCNVCDDFDLCY
GCYSAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLANG
-EEVEGEKLDSQILSHARVLQHQCIQLIGDCLMKAQQGK--GLKNLALLCMLPEGESLSE
ND---TVSVSPPTDGALKS-HTGD-----K--AGKGKDE-KPSTGSLM------HSHGKR
DTH-NEIQPPAGDKVQKHGSESDHNTVS---AKNAVLRQGSELSVEDNIT---PTGKIDD
CI----SEDSAQKQTEKVLIPSQEQVFAECSQKRILGLLAAMLPPFKSGS--TMSLINLE
QILPLMFQVVISNAGHLNETYHLTLGLLGQLILRLKPAEVDAAVAKVLSTKHSLFAAGDP
-STVPEGWKTTHLLFSLGAVCLD---SRVGLDWASSMADILRSLNSSAQWHSVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGTRSVYMDNANEAHNVIILKHFTEKN
RAVVVDIKTRKRK-TVKDYQLIQKCEQEGSDS------QAQLRQYLQHFVLICTHLLQTT
IDSSYAEAVEATWVLSLALKGLYRTLKIHGFQE-VQAAFLQSGLLKLLVKKCSKGTGFSK
TWLLRDLEV---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGTTP------GS---
--GPAAP--ALPPAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSTVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLIRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTITDQLDTQYDASSLISSMASVSQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSADDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARTEAEK-N
ILCAQCKKEA-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPRKECICAQTLLLQLLQSCFSVLQGDTLAAP-EEKPPTQRPEE----TEA
AKALYAHLCD-------VVDRVDGDCVPMGILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNISEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLSV
AARECELLMLSGVQGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKELAADLIEKYVV
QFLASTRVILESFLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDIPHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QIGSSMAI
PQAKMASVLNSPLWKPVFRHQICPELELEASWPTYPHQDGKEVKNIPDDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSRGKIPLSEDFAQVYSLADGIRIWML------------EMKQKSLMSLGSEADEKH
GLE-AAEAHPENL--AKECIQKSLLLLKFLPTGKSSKEHLDKLLTV-DENDHL--QPLDR
HQRTSSVVEDHFQASASTTEAS-PSTARD---KSPGLDIHPK----------LPPSSSPP
ATEAS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDVMD
FIKDHSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAVKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSMISQWSEEDELADAKQNSE
WMDECQDGMFEAWCEKIAQEDPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EDVDGEKLDPQAHSHATTLRSQCMQLAGDCLMKAHQGK--GLKALALLGILPDGGSTPE
---MQALAVTVPSCTSE------------EPAEAG--PF--------------VQCNGKR
-VVDEEI-GPLDYKQRN---KA-DEGLL-VMKDPSCQTQTVEVSAD-ADLPS---GLPAA
EN--SEA-SSQKLMEEKAVTPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIGLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPVEVDAAVIKVLSAKHNLFAAGDN
-AIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWQDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESS-----DCQAQLSQYSQHFAFIASHLLQTS
MDSHCAEAVEATWVLSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLEMDEQEE----EVEQPVSSPGEPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQRKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTQSDLCD-LALLKPLWQLFTHMEYTMFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGMMQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------FTDIFAESKESLDVHSSVILRFLHRNRA
SGTAIPYPMLDHCGNMCTMRASVLKESLDQLVQKEK-XXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIRGLRAXXXXXXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXX
XXXXXXXKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCSSTPEVELTLLAF
ALARGSVAKVLNSLCTITDHLDTHYDALSLISSMALVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAIQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKRRIGCSPDDLEENDPIGW
FELEEEWDEADVKLQQCRIAKYLMVKFLCTRQESAERLGVQGLSISGYLRPIRAEAEQ-S
VVCAHCKKDSEERVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYRSFLDFAGLDLQIF
WNFYNKLKQNSREECICAQTLLLQLLQSCFSVLQGETPAASQRTKKT---TNQNPGRIEA
AKELYSHLCD-------VVDRVNEDSVPMEILKQEVRNSLLNGAAVFFPDRQIRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKGDQADLNIDEVLAVMSTLLSV
AARECELLMLNGTQGEFGSVLFSLFWSVQGSLLSWCYLQLKSTDSEAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHDVSIFVSPG
ATYFEVEFDEKCETEKRYDYLEFTDSRGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKTVH-KLGSNMAL
SQAKMASVLNSPLWKPVFGHQICPELKLETNWPTHTSQNSKEVKNIPDDPCHRFLLEFAQ
SDPSQNFSGPYSELFKGFTQACKKQALKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKAALSEEFAKVYALADGIRIWML------------EMKQKLLMRLGNEAEDQC
ELEAAAEANPEIL--AKECIQKSILLLKFLPVGINSKENCDRMVTT-DETAQL--QPLDK
RPRTSSVVEEHFQASPSPTEAASSA--AG---DSSGVDVQTK----------MPASNGPV
TPDVTSAMIEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEVRAVPPMKEKYPVLKDVMD
FIKDQSLSHEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXYFGHLEGCGADLHKQIRDTYYQLVLFLVKAIKEFNSLNDXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX---X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLANT
-EEVDGEKLDPQARSSAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGNFASE
---NQAPSATVPTKTSEDQLTK-TVPTAEELSDSG--QS--------------VQCNGER
-DVNKET-RPLDCKKRN---KADE-GIL-----LTKQTQISDSPADANT----TTELPDA
EN--SEV-LPQKTIEEKAVTPNPEQVFAECSQKRILGLLAAMLPPLRTDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDN
-SVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGQ-ECR-----NSQAQLRQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKILKVQGFQE-THATLLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELAT
DEKIRTLAQKWQPRRSLRLEEQNAKAVDTDMIILPCLSRPVCCTQATPESNPVTQKLISC
TESELQKSYAKQRRSKSAALLHKELNCKT-------K-RAVRDYLFRVNDATAVLYARHV
LASLLAEWPSNIPVSEEILELSGPAHMTYILDMFMQLEEKQQWEKILQKVLRGCQESMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GYEILKKMLSEKKVVRHLPLSKIWEWMVGVAC-RQTGHQR
LKAIHLLLRIVRCCNRRDLCD-LALLKPLWQLFTNMEYSVMEDVTQRRIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATC
LWNVEC

------------MGNVPSNSSEDEAAAAGAEGW-SP-HQDWAADSGTTS------GS---
--GPGAP--ALPPAAALLEPARLREAAAALRPSPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMD

PF03256 // ENSGT00890000139411_0_Domain_1 (291, 429)

KL-KSVTKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLYNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSLAKVLNSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKQFEKYDSWKLQELRQFVKSRIGCSSDDLGEHDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEK-N
ILCAHCRKEA-ESVCGGTLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQRDALAAP-EEKPSTQCLGE----VEA
AKALYIHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVSEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLSV
AARECELLMLSGAQGQIGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKELAVDLIEKYVV
QFLASTRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDIPHCTLLRDFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLSSQCMALKSVH-QVGSNMAI
PQAKMASVLNSPLWKPVFRHQICPELELEASWHTHPHQDGKEVKNIPDDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPELYEKLQ
KYVNSGGKTPLSEDFAQVYSLADGIRIWML------------EMKQKSLMNVGSEAEEKH
GLE-AAETNPESL--AKECIQKSLLLLKFLPMGKSSKEHCDKLVTA-NETDHL--QPLDR
HQRTSSVMAEHFQASVSPTEAS-PSTVGD---RSPGLDIHPK----------LPPSSGPP
AAEVS--TAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKTQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLAC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAVKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIQLPDLLMKMSQENISVHDSMISQWSEEDELADAKQNSE
WMDECQDGMFEAWCEKIAQEDPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EDMDGEKLDPQAHSHATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDTTPE
---MQALPITVSTCTSE------------EPAEPG--PF--------------VYCNGKR
-AVDKEI-RPLGYKQRN---KT-DEGLL-IMKDPSCQTQIAGVPAD-ANLSS---GLPAA
EN--SEA-SSQKPVEEKTAPPNPEQVFAECSQKRILGLLAAMLPPVKLGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFASGDN
-AVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESI-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQTTFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEEVEQQPVSSPGEPEQKKLDP
LEGLDEPT---RICFLIAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPEHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTHMEYGLFEDMTQPGIL-LPLHRALTE
-LFFVTENRAQELGLMQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATH
LWNVEC

------------MGNATSNSSEDEAAAAGGEGW-GP-HQDWAADSATTP-----------
GSGLAAP--SLPSAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLGTHSSMILRFLHRNRI
SSTSIPYPLLEHCNNMCAMRSSVLKEALEQLVQKEK-ESPGDLTRSPEMDKL-KSVTKCY
AYIETSSNPAD

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRGPSDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQKVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPTFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLLRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYEASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTDSAIQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFRAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSADLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILCAHCRKDTD-GVSGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKKNPREECICAQTLLLQLLQSCFPVLQRDVLAATEEGKPPAQSPAG----AAA
AKALYTHLCN-------VVDRAAGDSVPMEILKQEVRNTLLNGAAVFFPDRQTRRNHLFA
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSELADMNISEVLAVMNTLLSV
AARECELVMLHGAQGEAGSVLFSLFWSVQGSLLSWCYLQLKSSDSAAKDLAADLIEKYVG
QFLASMRAILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDLCPLDISHCTLLREFS
TLTELLKKLCSDSGG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALRSVH-QLGHNMAV
TQAKMALVLNSSLWKPVFRHQICPELELEANWPTHPHHDRKEVKNIPDDPCRRFLLDFAQ
SEPAQNFCGPYSELFKGFTQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTTLSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNETEEQR
GSE-AAEANPEIL--AKECVQKSLLLLKFLPTSIHSKDSSDKQVAVDEPDHL---QPLDK
RPRTSSVVEEHFQASASPTEAAPA-TAGE---RSPGVDVQAR----------LSPGSGPP
AAEGSCATAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSQESVVQVLALKKAQAQGILEVLRIIQYCAESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGAELHKEIRDTYYQLVLFLVKAIKGFSSIND---RSLLPAFSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAYPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAGT
-EDVDGEKLAPEARSSAATLRSQCMKLVGDCLMKAHQGK--GLKALALLGILPDGNSAPE
---HQAPAVPGPCCISEEPLPKKGTRAAEEPPEA--------------------NPCGEE
-AFCKEV-SPSGDKQRA---KAG-EDA-------SLTAQTSDSPANAGP----PAGLPDT
EN--AEA-SSQKPVEEKAVTPHPEQVFAECSQKRILGLLAAMLPPLKSDP--TIPLMDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQVIVRLLPAEVDAAVIQVLSAKHNLFAAGDS
-AVVPDGWKTTHLLCSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWHDVLAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYIDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRKTG---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------

------------------------------------------------P-----------
APPPPGP--ARGPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRGLEE
RL------GRGEESVTLEQFRELLMARVARCNG--ENFHVAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLIPGFIDIFSESKEGLDVHAAMILRFLHRNRL
SSTVIPYPMLDHCNNMSTMRASVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPAD

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCRSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLAEPWTRDVGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDILGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-N
IVCAHCRKGTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSALQGDAPAATEDAKAPSPRPRP----VEA
AEELYAHLCS-------VVDRLDGDSVPMEILKQEVRNTLLNGAAIFFPDRLTRRNHLFT
MMHVT-EQERKQSMQLTFRSLCTYFSDKDPGGLLLLPEKGELADMDISEVLAVMNTLLSV
AARECELLMVDGAQREVGSVLSSLFWSVQGSLLSWCYLQLKSTDSGAKDLAADLTDRYVG
QFLARMRVILESLLSQYSGKTIVEKLCNSVLSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTELLKELCSDPDG-GVNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQIHPELGLEASWPTHPPQDIKEVKNIPDDPCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALSEEFAQVYSLADGIRIWML------------EMKQKSLMNLGSEAEDQR
GPE-AAEANPESLDSAKECYQKSLLLLTFLPTGGGSKESCDKSVAVDDTDHLQ---PLDK
RQRTSSVVEEHFQASASPTEAAPP-TAGD---RSPGPDVQPT----------LAPSSGPP
ALEVSSVPAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDLMD
FIKDQSLSHESVVKVLSLRKAQAWSILEVLRIIQCCTESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFNSKND---RSLLPALSCIQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISAHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMHCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQVRSSAATLRSRCLQLVGDCLMKAHQGK--GLKALALLGVLPDGGSPPE
---NQALPVTVPTQTSEEQPEKKAVQAAAEP-AHAGPAG--------------HRS-GKR
-DAPKEF-RPLDCKQRS---KAS-EGIS-LRKDPSCLTQISDSPADACT----PTGLPDA
EN--SEA-SSQKPIEEKAVIPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPVEVDAAVTKVLSAKHNLFAAGDS
-SVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVVATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRKTAVKDYQLVQKGGGQEGS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKVHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGELELDERGDQEEEV-ERSASSPGDQEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPVRCEQATVESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEDKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTQMEYSLFEDVTQAGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGATP------GP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGTHSSMILRFLHRNRV
SSMVIPYPMLDHCNNMCTMRSSVLKDSLDQLLQKEK-ESPGDLARSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCAISDHLDTQYDASSLISSMASVRQSLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDRWKLQELRQFVKSRIGCSPDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILYAHCRRDT-ENIYGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDPQAVSEEEKPAAQRPEG----IQA
AKELYTHLCD-------VVDRADGESMPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFT
MMKNVTEHERKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLATMNTSEVLAVMNTLLSV
AARECELLMLGRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNLAI
SQAKLTAVLNSPLWKPVFRHQICPELELEASWPTHPHQDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVHSGGKIALPEEFSQVYSLADGIRIWML------------EMKQKSLVSMGNDSEEKR
GLE-TAEVNPENL--AKECIQKSLLLLKFLPMSKSSKENCDKLVPV-DETDRL--QPLDR
RQRTSSVVEEHFQGSASPTEAA-TPAADD---KSPGLEMQPK----------LLPSSGPS
AAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESIVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFSSIND---RSLLPAVSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISIHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRFIQPYIHNYSWLLFAALALYSAHLTST
-EHVDGEQLDPQARGSAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTVSIQASEEQLEKKTAQPAEGPADAG--LF--------------VPCNGKR
-ATDKEV-GPLDCKQKK---KA-GEDLS-IMKDPSCQIQVSDPPAS-DHV---PPGLPDA
EH--PDR-SSQAPMEEKAITPSPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSAKHNLFATADN
-AVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKTHGFEE-THATFLHTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTEHGDLELDERGDQEEE-LDRPVSSPGEAEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSDQATSESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRESMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LGLLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLVAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPADLTRSPEMDKL-KSVAKCY
AYI

PF03256 // ENSGT00890000139411_0_Domain_1 (304, 429)

ETSSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECIAAQTLLLQLLQSCFSVLQGGVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSSDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKIIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEANPESL--AKECIEKSLLLLKFLPTGIRSKESCDKLETADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSIVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQAVPVTAPTQASEEQLEKKTLQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LTKDPSCQTQISDSPADAST----PKGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFITSHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAASGGEGW-GP-HQDWAADSGTTP-----------
GQGPAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFGELLEARGAGFSG--ERFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDVHAAMILRFLHRNRL
SSTVIPYPMLDHCNNMSTMRASVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-

PF03256 // ENSGT00890000139411_0_Domain_1 (294, 429)

KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCRSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLAEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDILGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IVCAHCRKGTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDAPAAAEDAKDPSPRPRP----VEA
AEELYAHLCN-------VVDRLDGDSVPMEILKQEVRNTLLNGAAIFFPDRLTRRNHLFT
MMKHVTEQERKQSMQLTFRSLCTYFSDKDPGGLLLLPEKGELADMDISEVLAVMNTLLSV
ATRECELLMVDGAQREVGSVLSSLFWSVQGSLLSWCYLQLKSTDSGAKDLARDLTDRYVG
QFLARMRVILESLLSQYSGKTIVEKLCNSVLSMAARQLVIFLLDFCTLDVSHCTLLREFS
ALTELLKELCSDPDG-GVNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQIHPELGLEASWPTHPPQDIKEVKNIPDDPCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALSEEFAQVYSLADGIRIWML------------EMKQKSLMNLGSEAEDQR
GPE-AAEANPESL--AKECYQKSLLLLTFLPMGGGSKESCDKSVAMDDTDHLQ---PLDK
RQRTSSVVEEHFQASASPTEAAPP-TAGD---RSPGPDVQPT----------LAPSSGPP
ALEVSSVPAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDLMD
FIKDQSLSHKSVVKVLSLRKAQAWSILEVLRIIQCCTESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFNSKND---RSLLPALSCIQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISAHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMHCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPEVRSSAATLRSRCLQLVGDCLMKAHQGK--GLKALALLGVLPDGGSPPE
---NQALPVTVPTQTSEEQPEKKAVQA----------------------------A-GKR
-DAPKEF-RPLDCKQRS---KAS-EGIS-LRKDPSCLTQISDSPADACT----PTGLPDA
EN--SEA-SSQKPIEEKAVIPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVTKVLSAKHNF------
---------------------------RVGLDWACSMAEILRSLNSAPLWRDVVATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQEGS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKVHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGELELDERGDQEEEV-ERSASSPGDQEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPVRCEQATVESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELSCRS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGRVPVSEDILELSGPAHMTYILDMFMQLEDKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGFGTGLYLFRGKSSRAFPYTLYYRFTSDMSN
TE----FTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTQMEYSLFEDVTQAGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

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------------------------------------------------------------
------------------------------------------------------------
--------------------------------FIDIFSESKESLGAHSAMILRFLHQKRV
ASLALPYPLLDYCHTMCAMRSSVLRESLDHLVQKDK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

EGPGELNSSQESEEL-KAIAKCY
TYIETSSNSADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTVAVGRSAGNLQEVRDVHIPSNVTGYVTLLENANISQLYVQINVKRCLSDGCDT
RIHGLRAVGFQRVRRGGVSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------SPVFV---Q
TILQNTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRILQPSLQACD
VKGKEDRSGPENLLAEPWTGDXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
XXXXXXXXXXXXXSEKFHAE-EFKRFEKYDTWKLRELRHFLKSXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXYLMIKFLCTRKDAAERLGVQGLSMYGYLRPAGVELGP-S
AVCATCIPK--ASICGMTLLLKTLSFVQQLAQDL--ARQKESGLKHKPLLDTAGLSLQLF
WGFYSKL--EPREECVLARCMLLQLLQSCLSELLVPSA------------------QSAA
PEELYAHLCQGSWGGGAVVDQVGDDSGSLKRLQVEVRNTLLQGAAVFFPDGHARRRHLFA
ML-TITEPEQKPSAHLTFRALCTYFSGRDPGGLLLLPEKGGPEGLDMGEVLAVMDMLQAA
AARECDMLMQEEAPGGESPALFSLLWSVQGSLLSWCYLQLKGSEPRAKKLAAEMVERYVG
QFLASMRVVLRSLLSQYSGKTIVESLCDSVFAMATRQLVIFLLDFCPLDIPHLALLKDLS
TLTDLLKGLCSDPSG-GPSQMDMDIWQQ-EKPVVLNTWTMESAHNYNNNCHEVAVFLSPG
ATTFEVEFDDKCETETRYDYLEFTDSRGLKTRYDTKVGTDKWPKKVTFKVGPQLHFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCLALRAD--QLGGDVGL
PMAKVTPVLHSPLWKPVFRHQLCPERVPGACGPATLPQDGKESRSAQADICRDLLVDFAK
SDPAQGFCGQSPELFQGLTQACKKQAPQTDSVASSAVDRAVNAAFAALVYLTPQLYEKLQ
SYVNSGGQGVLSEEFAXXXXXXXXXXXXXL------------EMKQKFLLDKGDEMAGEV
DAA-MQEVNPENL--ARQCAQKSLLLLRFLPVGVSPKVGPWEVSAGPDEVVPL--QLQGH
RHRGSSVGEEHFQASGPE---------------SPWQQRG------------F------S
ASGTPLVTAGRPSPPSTPTRKPALGRGRLRLLSFRSV--EEARPVPTVTEKYPLLKDVMD
FIKDQALSRESVLKVLSLKKALAERVLDALKATQPRVELLGRPHCFQPPCLLFLLELLTC
QKDFVNYFGHLEGCGAELHREIRHAYHQVVQFLVEAVKGFSALKD---RSLLPALSCVQA
SLL-HLLDMGWEPSDLPFLLEIRLPELLMAMSQENISLHDSVICQWSEEEELASYKQMSE
WMEECQDGMFEAWYEKIAQMDSDKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1945)

LNVDISCDGCDEIAPWHRYRCL
QCHDMDLCKTCFLG--GVRPEGHE

ENSGT00890000139411_0_Linker_2_3 (1945, 1950)

DDHEM

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEYACDHCRGVIVGRRMNCNVCDDFDLCY
GCYSAKKYSASHLPSHGITVYPMVTIRTSDRQRLIQPYIHNYSWLLFAALMLYSADLASG
-GEVEGEKPGTRPN-SAVALQGQCLQLIGDCLVKAQRAK---------------------
------------------------------------------------------------
------------------------------------------------------------
--------SSLKTVEEKFVALSPEHVFAECSQKRILGLLAAMLPPLQSGS--TISWANLE
HILPLMFQVVISNAGHLNETYHLTLGLLGQFIIRLLPAQVDAAVTMALSAKHTLFSAGDG
-SPVPEGWKTVHLLFSLGAVCLD---SRVGLDWACSMADILRALHGAP-WHGVVAAFTEH
CLKQLPCQ--LKHTNIFTLLVLVGFP---EVLCVGARSVYLDNGNEPHDVIVLKHFTEKS
RAVVVDVKTRKRN-TVKDCQLARPCGQGSV------ASSTPLSSHLQYFTSISSQLLRSC
LDHSCSEAVEATWVLSLALKGLYRTLKAHSFEG-IHTVFLESGLLKLLVKKGSRGTGFSK
TWLLRDLEILSVLLYSSKEEHRAPQEPGAG------------PLQPGSPPGDTGQSKPDP
LEGLDEAT---KVCFLMTH-DALNAPLPILRAMYELQMKRTESFFLEVQR-RFDGDVITT
DEQIRTLAQKWQPRKHLQLEEPASRAVDTDVTVLPSWSKPATCDRVAEESDPVTQKLITS
TEGDLQLSYAKQRRAKSAGLLHKELGSQA-------K-GAARAYLHRVNEATAILYARHV
LASL-AQWXXXXXXXXXXXXXXXXXXXXXXXDMLMQLEETQLWEEILHKVLRGCSEDMLG
PMALAACHFMEEPGTAVQARESKHPYKNNTTFEDKVHIPGAIYLSVKFDPQCSTEEGCDE
LTVSSSSDLQQDRHSFSGSSQKWIDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKKLLSEERTRPHLPLANIWAWQVGVAC-RQTGHQR
LKAIHLLLKMVQCSAP--------------------------------------------
------------------------------------------------------------
------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QVFAQFDVEADGPVDVENMLE
ALKSSR-GASLPG--ELSHITRQLQACSLVPGFIDIFSEGTESLGAHSAMILRFLHRNRI
ASMALPYPLLDYCHTICAMRSSVLRESLDQLVQKDK-EAPGELNGSPESDQL-KAVAKCY
TYIETSSNSADI

PF03256 // ENSGT00890000139411_0_Domain_1 (313, 395)

NKMTNGETSSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTVAVGRSASSLQEVRDVHIPSNVTGYVT

ENSGT00890000139411_0_Linker_1_2 (395, 1903)

LLENANISQLCECGR-----------
--GPSRAGGLVRRR----------APWGLTNVAAQTRLVRPPVLPVPAGPERRAYVPQPH
LCPASSRKALQHMPPLSLSPASTDGASFLSPSVLGEVDGFLVRITSCLANPEVELTLLAF
ALARGSVAKVLSSLCAITDHLDAPYQASALIASMAAVRQNLLYKYAWPGRILQPTLQACD
VKGKGEKSGPENLLAEPWSGD-GFLTETGKTRASIIFSTGTEAAFQVTQLRIKVRRGGIG
AQCGLVFAYNTP-SERFQAEEHFQRFEKYDTWRLPEYRQFLKSRVGSAWADLGEDEPAGW
FEAEEDWDEVEVKMQPCRVAKYLMVKFLCTRRDTAERLGVQGLSVYGYLRPADADLGP-G
TRCATCDPEA-DRICGMTLLLKTLSFVQQLAQDL--ARQRESGFKHKPLLDTAGLSLQLF
WGFYSKLEARPREECILARTMLLQLLQSCLSELTAGPQATAGSPPPPSSCV------PAV
PEDLYAHLCQ-------VVDEAGDDPVPLKRLQAEVRNTLLQGAAVFFPDGRARRRHLFA
MMKNITEPEQKPSAHLTFRSLCTYFRPGGGGGGGCEEACCRPALATAGQGPAVTPCPHLG
PPSQCDMLMQDASPGESGPALFSLFWSVQGSLLSWCYLQLKGSEPRAKQLAAETLDRYAG
QVLASVRTVLRSLLSQFSGKKVVEKLCNSVFAMATRQLVIFLLDFCPLDIPHLALLKAFS
TLTDLLKDLCSDPNG-SPEQMDVDTWQQ-EQPVVLNTWAMESAHNYENNRHEATVFLSPG
ATSFEVEFDDKCETETRYDYLEFTDARGLKTRYDTKVGTDKWPKKVTFKAGPQLHFLFHS
DSSNNEWGYKFTVTAYGLPDVAISWGLDLQLLVSRLMGRLASQCLALRADR-ELGSDMGL
PVAKVTPVLHSPLWKPVFRHQLCQEGLLGACGPTPAPQDGRESRSAQADPGWDLLVDFAK
SDPAQGFCGRRPELFQGLAQACKKQAPQTDSVAGSAVDRAVNAAFAALVYLTPQLYEKLQ
SYVTGGGQGVLSEDFAQVYSLADGIRIWML------------EMKQKALLEQGDEGSGEP
DAD-VHEVNPESL--ARECAQKALLLLQFPPMRASRQRG---------------------
----GSVGEEHVPA------------SGP---ESPRQQVEAA----------LGPSSRPL
E-RSTSQQDEGLSPPSTPTRRPTFGRGRLRLLSFRSV--EETRPMPTVTEKYPLLKDVMD
FLKDQALSHESVLKVLSLKRAQAKSVLDALSTARTCMEQLGRPHCFHPACLLFLLELLTC
QKDFADYFGHLEGCGAALHAEIRHAYHQLVRFLVDAVKGFGNLKD---RSLLPALSCVQA
SLL-HLLDMGWEPSDLPFLAEMRLPELLMTMAQENISLHHRAICQWSEDEEMAEYRQTSE
WMEECRDGMFEAWYEKIGQADAEKQRKMHMNIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCHDMDLCKTCFLG--GVKPEGHEDDHEMVNMEYACDPCQGVIVGRRMNCDVCDAA----
------PLLCSHLPSHGVTVYPMVTIRTSDCQRLVQPYVHNYSWLLFAALTLYAADLAGG
-AEAEGERPDPGALQAAATLQAQCLRLLGECLLKAQRNAENELVS---IGSSQDGAGEEK
AAETTGTPTAVPSWASLLIIGPRGRQGRDPP----------------------VRGRAGR
-SGCRGV-PGTEAGWAL---MAD-LGGD-PPPTPCCWTGPTGSPGAPDPPAPRPLGLGQA
GD--AGA-SPVWAMREPIVPPSPEQVFAECSQKRILGLLAAMLPPIQSGS--TVSWANLK
DILPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVTGVLSAKHGLFSAGEG
-AAAPEGWDTVHLLFSLGAVCLDSFGSRVGLDWACSMADILHTLHGCPHWHGAVAAFTEH
CLKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGARSVYLDNANEPHDVIVLKHFTEKS
RAVVVDIKTRKRK-TVKDCQLVRPCGQG-GT-----ASPTPLSAHLRHFTFISSHLLQSS
LEPGCPEGPGASTLASLLRFPVLLP--SFALPNPAASAFLR-------------------
-------------------------------------------GETLPRPGVS---AALP
LPCLSLPSLLLALTLQMTH-DALNAPLPILRAMYELQMKRTDSFFLEVQR-RFDGDVITT
DEKIRSLAQKWQPRKRLRLEELTSRAVDTDMIVLPCWAKPVACDRAAEESDPVTQKLIAS
NESDLQLSYAKQRRAKSAGLLSGRRQRAC-------AGSRAR----------------DL
--------------------------------------CPSCPRQILHKVLQSCSQDMLG
PMALTACHFMEEPGTAVQVRESKHPYKNNTTFEDKVHIPGAIYLSVKFDPQCSTEEGCDE
LAMSSSSDFQQDRHSFSGSSQKWIDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKKMLSEERVVPHLPLAKIWAWQVGVAC-RQTGHQR
LKAIHLLLKMVQCRGHRGGALWAALSAPRWELVESPCRGWTVPVREVVLR-VPSQSAFCD
PLGLAVGREPQELGSPQDYLLAL-----TTDDYLLCCTAQ--------------------
------

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGTTH------RP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMSTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGSESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SNKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYHRPGRAEAEQ-S
ILYAHCRRDT-ENIHGATLLLRTLQFIQQLAHDL--VQQKEGGLKYKSFLDFAGLDLQIF
WKFYSKLKQNRREECICAQTLLLKLLQSCFSVLQGDPQAASEEEKPTAQRSER----IQA
AKELYTHLCN-------VVDRPNGNSMPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFT
MMKSVTENERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLATMNTSEVLAVMNTLLSV
AARECELLMLNRANGAVGSVLFSLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
SQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHSHKDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALTEEFSQVYSLADGIRIWML------------EMKQKSLLSLGNESEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPMSKSSKENCDKLVPV-DETDHL--QPLDR
RQRTSSVVEEHFQGSGSPTEAA-TPAAGD---RSPGLEIQPK----------LLPSSGPS
VAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYTAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EQVDGEQLDPQAHTNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTESFQASEEQLEKKAAQLFEERADAG--LF--------------VPCNGKR
-AADKEV-RPLDYKQKK---RA-GEDLS-IMKDPSCQTQVSDARAS-AHV---PPGLPDA
EH--PEV-SAQAPVEEKAITPNPEQVFAECSQKRILGLLAAMLPPMKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSAKHNL------
---------------------------RVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQSQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEE-LDRPVSSPGEAEQKKLDP
LENVDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRCLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSDQATPESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATSVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LGLLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSYSSEDESAAAAGEAW-GP-RQDWAGESGT-------------
----------------LLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEELVTLEQFRELLEARGAGCSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALKN

ENSGT00890000139411_0_Linker_0_1 (185, 278)

SS-GANLQG--ELSHIIRQLQACSLVPGFVDIFSESKEGLGVHASMILRFLHRNRI
SSTVIPYPMLDHCNNLCSMRSSVLKESLDQLLQKEKA

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ETPGDLTGSPETDKL-KSVAKCY
SYVETSSNPADADKMTNGETSSYWQSD--GSSCSHWVRLKMKPDVVLRHLSIAVAATDLS
YMPQQVTVAVGRTPSDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLRDGCDT
RIHGLRAVGFQKVKKSGVSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPSVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSSGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRIAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARADTEQ-S
VVCAHCRKDSEESVCGATLLLKTLQFIQQLAHDL--VQQKESGFKYKSFLDFAGLDLQIF
WNFYNKLKQNPREECIYAQTLLLQLLQSCFSVLQGDAPVVSEKEKAPKQIPKG----MEA
AKELYTHLCD-------VVDRVSGDSAPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLADMNIIEVLAVMNTLLSV
AARECELLMPSGAQGEAGSVLFSLFWSVQGSLFSWCYLQLKSTDTGAKDLAVDLIEKYVQ
QFLARMRVILESLLSQYSGKIIVEKLCNSVFSMAARQLVIFLLDFCTLDMPHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTEKWPRKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLRSNMIV
PQAKMVLVLNSPLWKPVFRHQICPELELEAYWTTPPHQDSKEVKNIPDSPCRNFLLDFSQ
SDPARDFCGPYSELFKGFIQACRKQAPKADIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQRSLMGLGNEAEEKL
NSE-TTEANPESL--SKECIQKSLLLLKFLPAGIHSKESCDQLVTAAET-DSL--QPPDK
RQRTSSVVEEHFQASASPTEAAPP-VAVD---GRLGLDVQPK----------LLPSSGAS
TTEVSSATAEEPSSPSTPTRRPAFTRGRLRLLSFRSM--EEARPVPTIKEKYPVLKDVMD
FIKDQSLSHDSVVKVLSLKKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLTC
QKEFTNYFGHLEGCGAELHKEIRETYYQLVLFLVKAVEGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVSIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMEECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCGL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFACDHCRGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHVASA
-EDVDGEKPDPQARSSATTVQSQCVQLIGDCLMKAHQGK--GLKALALLGMLPDGGSTPE
---NQSLPVPLPTRTSGMLLEKKAVQAAEEPS-EAGAFV--------------D-CSGKG
-AAHKET-RPLDCGQRG---KAG-EGVS-LTKDPSCQTQTADSAADVST----PPGLPGA
EN--SEP-SPQKPVEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDQE
HVLPLMFQAVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVTKVLSARPN-------
--------------------------LRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIVLFNFLKAG
LNIMAGTEVRH-RPSVKDYQLVQKGGEQEGS-----DSQAQLSQYSQHFAFIVSHLLQTS
MDTHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDVLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNILTEHGDPELTEQEDQEEEA-ERSVSSPSETEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHVLRAIYELQMKRTESFFLEVQK-RFDGDELTT
DERIRTLAQKWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCEQATAESNPVTQKLISS
TESELQQSYAMQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHMPVNEDVLELSGPAHMTYILDMLMQLEEKQQWEKILQKVLRGCRENMLG
TMALTACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGRD----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLARIWEWLVGVAC-RQTGHQR
LKAIHLLLKIVRCCTHRDLCD-LTLLKPLWKLFTQMEYSLSEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATL
LWNVEC

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGTTP------GP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGSDSAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SNKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILYAHCRRDT-ENIHGATLLLRTLQFIQQLSHDL--MQQKESGLKHKSFLDFAGLDLQIF
WKFYSKLKQNRREECICAQTLLLKLLQSCFSVLQGDPQAASEEEKPTAQRSEG----IQA
AKELYTHLCN-------VVDKPNGNSMPMEILKQEVRNTLLNGAAIFFPDRQTRRSQLFT
MMKSVTEHERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLATMNTSEVLAVMNTLLSV
AARECELLMLNRSHGAVGSVLFSLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFISPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
SQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHPHKDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALTEEFSQVYSLADGIRIWML------------EMKQKSLLSLGNDSEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPMSKSSKENCDKLETV-DETDHL--QPLDR
RQRTSSVVEEHFQGSASPTEAA-TPAAGD---RSPALEIQPK----------LLPSSGPC
VAEVS--TAEEPSPPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQGQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHREIRDTYYQLVLFLVKAIKRFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYTAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EQVDGEQLDPQARTNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTVSFQASEE------------QADAG--LL--------------VPCNGKR
-AADTEV-RPLDYKQKK---KA-GEDLS-IVKDPSCQTQVSDAPAS-AHV---PPGLPDA
EH--PEV-SAQVLVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSAKHNL------
---------------------------RVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQSQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEE-LDRPVSSPGEAEQKKLDP
LENLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSDQATPESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AIRDYLFRVNEATSVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEV---------------------------------QCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLALGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCSHSDLCD-LGLLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNVTSHSSEDEAAAAGVEGW-GP-HQDWAADSGTTP-----------
GPGLPAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHASMILRFLHRNRI
SSTVIPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVAKCY
AYIETSSNPTDVDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANISQPYVQINVKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKAGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVTKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFDKYDKWKLQEFRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
AVCVHCKKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVCAQTLLLQLLQSCFSVLQGDALAASEEEKAPAQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPVEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLADMNISEVLAVMNTLLSV
AARECELLMLNGAQGEAGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVA
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAR-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPPQDSKEVKNISDDPCCHFLLDFAQ
SQPAQNFCGPYSELCKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKR
GSE-ATEANPESL--AKECIQKSLLLLKFLPMGISSKESCDKLVTADET-DHL--QPLDR
RQRTSSVVEEHFQASASPTEGAPP-ATGD---RSPGLDVRPK----------LLPSSGPP
AAEVSSATTEEPLSPSTPSRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGAELHREIRDAYYQLVLFLVKAIKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIQLPELLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLGPQARSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---NQALPVTVPTRTSEEQLEKKAAQDAEALSE-R--E---------------------K
-AVHEEV-RPLDYKQRN---KAD-ESIS-LIKDPSCQTQISGSPADASP----PTELPDA
EN--SEA-SSQKPIEEKAVTASPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLILRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQEGS-----DSQAQLSQYSQHFALIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHDFEE-THATFLQTDLLKLLVKKCSKGL----
--------ILSIMLYSSKKEINTLAEHGDLELDERGDPEEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSVKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYARQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVAENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAGAAGGEGW-GP-HQDWAADASAIP------GS---
--GPAAP--ALPPAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEEAVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
TLKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHASLILRFLHRNRL
SGMAIPCPMLDHCSNMCSMRASVLKESLDQLVQREK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPAD

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQDVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDVSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSCLCTIADHLDTRYDASSLISSMASVRQTLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SEKFHAEEHFKRFEKYDKWKLQEFRQFVKSRVGCSADDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYVRPMRVEAEQ-H
IVCAHCRKDGEESVCGTTLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLRLLQSCLSVLQRDGPATPEEAKAPRQSPGG----AGA
AKELHAHLCD-------VVDRVDGDSVPMETLKQEVRNTLLSGAAVFFPDRQSRRSHLFT
MMKNVTEQEHKQSQQLTFQSLCTYFSDKDPGGLLLLPEKGDLADMNSSEVLAVMSTLLSV
AARECELLLLTRAQGQPGSVLFSLFWAVQGSLLSWCYLQLKSTDAGARGLAAHLIDQYVG
QFVASTRVILESLLSQYSGQTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCALLREFS
TLTELLKQICADPTG-APDKLDEDTWQQ-ECPVVLHTWTKESAHNYENNCHEVSVFISPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTEKWPRKVIFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWALDLQLLVCRLMGRLAAQCMALKSAH-QFGGDMAV
APAKMALVLNSPLWKPVFRHQLSPELGLAVSWPTHLHQDSKEVKNIPDDPCHHFLLEFAQ
SDPAQNFCGPFSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVCRTPGLYEKLQ
KYVNSGGNTALSEDFAQVYCLADGIRVWML------------EMKQKSLMNLGNEAEEKH
GPE-AAEANPESL--AKECIQKSLLLLRFLPMGVSSKESCDKLVAAV-ETDHL--QPCDR
CPRTSSVVEEHFQASESPMDTGTLA-ASS---GGPSSDVPLK----------LLPSGGPP
ATEVSFATAEEPSSPSAPARRPPFTRGRLRLLSFRSV--EEARPVPTVKEKYPVLKDVLD
FIKDQSLSHESVVKVLALRKAQAQSILEVLRIIQYCTESLGRPHCFHPPCILFLMELLTC
QKEFTNYFAHMEGCGARLRKEIRDTYYQFVLFLVKAVKEFSSMND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIGLPHLLMKLSQENISVHDSVISQCSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1951)

HGDDHEMV

PF00569 // ENSGT00890000139411_0_Domain_3 (1951, 1992)

SMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKRYSYGHLPTHGVTAHPMVTIRISDRQRLIQPYIHNYAWLLFAALALYSAHLASA
-EDVDGEKLNPQDRGSASLLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGEPSPE
---SRAPPVTVPTHTAEEER---AVWGPEDLPHTG--LS--------------MCYSGKE
-DGPKEV-RPLDSRQRS---KADEEGAS-LMNGPSCQTPISDTPAD-GS---TPARLPDA
EN--TVM-LSQESIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKLDP--TVPVIDLE
HVLPLMFQVVISNVGHLNETYHLTLGLLGQLITRLLPAEVDAAVVKVLSAKHTLFATGDS
-SVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIAAFTDH
CIRQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDHANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKG--QECS-----SSQAQLSQYSRHFAFIASHLLQTS
MDSQCPEAVEATWVLSLALKGLYKTLKAHSFEE-THTTFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKESHTSAEHTALERDERGDQEEEV-DGTVSSPGEPDQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRGLRLEEQSTKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQHSYAKQRRSKSTALLHKELNGKS-------KR-AIREYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDTLDLSGPAHMTYILDMFMQLEEKHQWEKILRKVLQGCRGSMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDSQCSTEEGCDE
LAMSSSSDFQQDRHTFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCTHSDLCD-LALLKPLWQLFTHMEYSLFEDVTSPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTDDHLLRCAAQALQNVAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------VSPLMSNIYR----------------------------------T
AVLGAC-GEGWEGREKVRILIPHSYYDSVSSGFIDIFSESKESLGAHSSMILRFLHRNRI
SSTMIPYPMLDHCNNMCTMRSSVLKESLDQLVQKER-ESPGDLIRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTHLK----P---------------------------PFSTTCCSTPEVELTLLAF
ALARGSVAKVLSSLCAIMDQLDTQYDASSLISSMASVSQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLRELRQFVKSRIGCSADDLGEDDPVGW
FELEDEWDEADVKLQQCRVAQYLMVKFLCTRQESAERLGVQGVSISGYLRPTRTEAEK-N
FLCTQCRKEA-ESVCGATLLLRTLQFIQQLAHDL--IV---------------------F
SKFYQA--SCLKEECICAQTLLLQLLQSCFSVLQGDALSAP-EEKPPARCPEE----VEA
AKALYTHLCD-------VVDRQDGDFVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVSEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLAV
AARECELLMLSGARGEAGSVLFSLFWSVQGSLLSWCYLQLKSSDSAAKELAVDLMEKYVV
QFLASTRVILESFLSQYSGKTIVEKLCNSVFSMATRQLVIFLLDFCTLDIPHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVEAWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKEGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QQTNCSIL
FR-----------------CA---------------------IFKKPSFPCLYFLPLLL-
---------SFSVLFLFFF-------------------------FPTLIL----LLPAKL
LHVNSRGKVPLSEDFAQVYSLADGIRIWML------------EMKQKSLMNLGSEAEEKH
GLE-AAEASPESL--AKECIQKSLLLLKFLPLGKSSKEPCDKLVTA-EENDHL--QPLDR
RQRTSSVVEDHFQASVSPTEASPS-TAGD---KSPGLDMHPP----------LPPVSGPP
AAEGL--MAEEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPVPTVKEKYPVLKD---
------------------------------------------------------------
-KDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFIDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMEECQDGMFEAWCEKIAQEEPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLE--IXXX------------XNLLDHCQGVLLTCTT------------
--GLKTSYLCSHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDIDGEKLDPQARSHATTLRSQCMQLAGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---MQALAVTAVVQ------------------------L--------------VVEPGKR
-TIDEEI-RPLEYKQKN---KAD-DNLL-IMKDPSCQTHIVDASAD-VN---LPSGLSAA
EN--SEA-SSQKPIEEKTITLNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIGLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVVKVLSAKHSL------
---------------------------RVGLDWACSMAEILRSLNSAPLWQDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESG-----DSQAQLSQYSQHFACIASHLLQTS
LDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEIHTLAEHGDLELNEQEEE----VEQPASSPGESEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQRKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAVDTDMIILPCLSRPARYEQATAESSPVTQKLIAN
TESELQQSYAKQRRSKSAALLHKELNCKG-------KR-AVREYLFRVNEATAVLYARHV
LASLLAEWPGHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESQHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLARVWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTQSDLCD-LALLKPLWQLFTHMEYALFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVMQDYLLAL-----TTDDHLLRCTAQALQNIAAISLAIGYSNKATR
LWNVEC

-------------XNASSHSSEDEAGAAGGE-A-GP-HQDWVA-SGTIS-----------
GPGPAAP--RCRP-AALLEPARLREAAAALRPAPP-------FESLVSRHHGALLRWLEE
RL------GRGEESVTLDQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRL
PSAVVPYPMLDHCNNVCTMRASVLKESLDQLVLKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNSA

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 427)

DIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAAADQS
YMPQQVTVAVGRTAGDLQEIRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKPGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTKIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSPDDLGEDDPIGW
FELEEEWDEAEFKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSVSGYLRPARTEAEQ-S
VVCARCRKDAEERVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNSREECICAQALLLQLLQSCFSVLQRDAPAASEDAQARRPSPGG----VEA
AKELYTHLCG-------VVDRVDGDSVPLEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMRNVTEQDHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKGDLADLHVSEVLAVMSTLLSV
AARECELMLD--GAGEVHSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLLEKYVG
QFLTSMRVILESLLSQYSGKTVVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-GLDKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQICPELGLEASWPTHPHQDSKEIKNVRDDPCHHFLLHFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVHSGGKTALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKL
GSE-AAEANPESL--AKECIQKSLLLLKFLPMGVSSKESCDKLVTLDES-DHL--QPLDK
RQRTSSVVEEHFQASASPTEAVTP-AAGD---RSPGLDVHPK----------LPPSSGPL
AAEVSSATAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQARSILEVLRIIQYCAESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEACGADLHKEIRDTYYQFVLFLVKAIKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYAWLLFAALALYSAHLASA
-EDVDGEKLDPQARSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTPE
---NQALSVTVPTGTSEEQLEKKAVEVAEE-------PE--------------YG-NGKR
-DVHKAV-VPLDFKQRS---KAD-EGVL-LMKDPSCQTQISDSPADAST----PTGLPDA
EN--SEA-SSEKPVEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLSPAEVDAAVIKVLSAKHNLFAAGDS
-SIMPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNGAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVVVDVKTRKRK-TVKDYQLVQKGGGQECG-----SSQTQLSQYSQHFAFIASHLLQTS
MDSHCSEAVEATWVLSLALKGLYKTLKAHSFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAEHGDLELDERGGQEEEV-EQSVSSPSEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRMDEQSAKAVDTDMIILPCLSRPTRCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRMVRCCTHSDLCD-LALLKPLWQLFTHMEYSLSEDVTQPVIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCTAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNSASHSSEDEAAAAGGEGW-GP-HQDWAADSGTTS-----------
GPGPAAP--ALPPAAALLEPARLREAAAALRPVPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALKN

ENSGT00890000139411_0_Linker_0_1 (185, 278)

SS-GANLQG--ELSHIIRQLQACSLVPGFIDIFAESKEGLDVHSSVILRFLHRNRA
SGMSIPYPMLDHCSNMCTMRASVLKESLDQLVQKE--

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCFSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSADFSTFLSPNVLEEVDSFLIRITXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX---XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXFLTETGKTRASTIFSTGTESAFQVTQIRIKVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKFQEFKQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEVDIKLQQCRIAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARTEAEQ-S
VVCAHCRKDTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYNKLKQNAREECLCVQTLLLQLLQSSFSVLQAGDTPAAE-----SKTPTQNPGRVEP
AKELYTHLCD-------VVDRVDGDSIPMEMLKQEVRNTLLNGAAIFFPDQQTRRNHLFT
MM-NITDQEHKQSLQLTFRSLCTYFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVS
QFLASMRVILESLLSQYSGKTVVEKLCNSVFSMASRQLVIFLLDFCTLDIAHCTLLREFS
TVTELLKKLCSDPEG-GLNKLDAETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKXXXXXXXXXXXXXXXXXXXXXXXXXXXXKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVVAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGNNMAV
SQSKMTLVLNSPLWKPVFRHQMCPELGTEASWPTHPYPDRKEVKSIPDDPCRHFLLDFAQ
SDPAQNFSGPFSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWMXXXXXXXXXXXXXX------------X---X
XXXXXXXXXXXXXXXXKECIQKSLLLLKFLPVSLSSKENCDKLATT-DEPAHL--QRLDR
RQRTSSVVEEHFQASASPTETAPPA-AGD---GSPGLDAQPK----------PLSSSGPL
AADMSSSVADEPSSPSTPSRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIRDQSLSHENVVKVLSLRKAQAQNILEALRINQYCTESLGHPHCFHPPYILFLLELSDS
RKEFTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHIVMVDYCDLLNVDISCDGLDEIAPWHRYRCL
QCSDMDLCKTCFLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLKALALLGILPDGDSTPE
---NQTLPVTVPTSKSEEQLGKNTVQAAEEPSDTG--PL--------------VQSNEKR
-DIHKDT-RPLDYEQGN---KADE-SVS-LSKDPSSQAEVTGSPADTS----VPTGLTDV
EN--PEVSSQKPIEEKAEVTPSPEQVFAECSQKRILGLLAAMLPPLKSDP--AVPLIDLE
HVLPLMFQVVISNAGHLNE-YHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDN
-SNMPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILK-FTEKN
RAVIVDVKTRKRK-TVKDYQLIQKGGQE-CS-----NSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX-XX--XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXMAH-DALNAPLHVLRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQNAKAVDTDMIILPCLSRPARCDQATAESSPVTQKLISS
TESELQQSYAKQRRSKSAVLLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPTHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLRGCRESMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXALQNIAAISLAINYPNKATG
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRI
SSTAIPYPVLEYFNNICTMRSSVLKDSLDRLLLKER-EYPSDLNGNQESDKL-KSVTKCY
THIETSSNS

PF03256 // ENSGT00890000139411_0_Domain_1 (310, 430)

ADIDKMTNGETSSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTVAVGRNASSLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLRAVG

ENSGT00890000139411_0_Linker_1_2 (430, 1903)

YQRVKKVAVSVCDASAIWYWSL---LTSLVTASMET------NPAFV---H
TILQNTQKALQHMPPLSLTPGSTDFSSFLSPNVLEEVDSFLIRITSCCTTPEVELTLLAF
ALARGSVAKVLSSLCAISNHLDTPYKASSLISSMAAVRQNLLYKY---GKPLRLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGRTRASIILSTGTESSFQVTQIRVKVRRGAIG
AQCGLVFAYNGA-SEKFHAEEHFKRFESYDKWKLREFKQFLKTRSSYSCDDFGDDDPIGW
FEVEEEWDEVDVKMQQCRVAKYLMIKFLCTRQDSAERLGVQGLSVLGYLRPLREEPCR-T
LSCLQCRKTEDDTVCGTTLLLKTLHFIQQLAQDL--VQQKESGLRYKSFLDFTGLDLQLF
WNFYNKLHQNPREECIFAQTLLLQLLQSCFSVLTGDNKTAKPQETPQ----SKTAGHTEA
AEELYRHLCE-------VVDMEDSNSMPMKMLKEEVKNTLLGGAAVFFPDRQTRRQQLFT
MMKNITEQEHKQSLHLAFRSLCTHFSDQDPGGLLLLPEKGVSANFDISEVLSVMDTLLLV
AARECEMMMLDVAQQESGVVLSSLFWSVQGSLLSWCYLQLKGTDDSAKDLAVEILKSYVG
QFLSNIRTILQSLLSQYNGKKIVEKISSSVFAMATRQLVIFLLDFCTLDIPHCTLLQGFS
TLIEPLKSLCSEPHK-----LDMESWQQ-EQPVVLRTWTMESPHNYENNCHDVSVFLCHG
ATYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFSVTAYGLPDVAVSWGLDLQLLVCRLMGRLASRSMALRSPR-ELGSEADL
PPLKVTSVINSPLWKPVFRHKMCPETLPGAR------QSKNEARSSPHDVCRNFLIDFAK
SDPAQDFSGQKSELFRGLIQACKKQTPKTDIVAGSTVDQAVNSTFAALVYLTPDLFEKLQ
KYVNSGGKVPLSDEFAQVYSLADSIRIWML------------EMKQKSLMGRGNDAEEKQ
NTE-ASEVNPEIL--AKLCVQKSILLLNFLPVRAKTK----ENLEAQDMDD-PQQYVSDK
CQRQGSAVDMDFQAAQPASSSAGIHPVSKEGGQTPQSDLKVKQIPGLHQAEAASALHSKP
VENTGSQQEEVSSPPSTPTRKSQLGRGRLRLLSFRSM--EEPRAVPTVKEKYPILKNILD
FIKDQSLSHESVLKVLALRKSQGQSIMEVLKTIRQCLDSLGQPHCFHPPCVLFLLELLAC
QKDFTNYFGNLEGCGAELHKEIRESYYQLVLFLVNAVKGFSTIND---RSLLPALSCVQT
ALL-HLLDMSWEPSDLSFFVEIQLPHLLMTTSQENISTHDSVICQWSEEDEIADYKQNCE
WMDECQDVTFETWYEKIAQADPEKQRKMHMFVARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPEGH

ENSGT00890000139411_0_Linker_2_3 (1944, 1952)

EDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEYACDHCQGVIIGRRMNCNVCDDFDLCY
GCYHAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLASG
-EEVDGEKLDPQVLSHARVLQHQCIQLIGECLMKAQHGK--GLKNSALLCMLPEDESFSE
SD---TVSGSPPTDSAPKS-HPAD-----R--AGKGRDE-KRSTGSLL------RRGGKG
DPH-KEIQSPAEDKVGKQE--IEIKAVS---AKKAVVRQESVDGND---------PATGD
SL----SEDSIQKPTEKVLIPSQEEVFAECSQKRILGLLAAMLPPFKSGS--TMSLMNLE
QILPLMFHVVISNAGHLNETYHLTLGLLGQLILRLMPAEVDAAVTKILSAKHNLFVPGDG
-SAVPEGWKTTHLLFSLGAVCLD---SRVGLDWASSMADILRSLNSSAQWHHVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGTRSVYMDNANEPHNVIILKHFTEKN
RAVVVDIKTRKRK-TVKDYQLIQKCGQEGSDS------QTQLRQYLQHFVLISTHLLQTS
MDSSYAEAVETTWVLSLALKGLYKTLKIHGFKE-IQSAFLQSGLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKQDISSLAEQEDSELEDREQDQDV-EQQPVVAPADSEQNKLDP
LEGLDEAT---KICFLMTH-DALNAPLHILRAMYELQMKRTDSFFLEVQK-RFDGDVITT
DERIRTLAQKWQPSKRLRLEEQSSKAVDTDMIILPCLSKPVLCDKATEETNPVAQKLITN
TESDLQLSYAKQRRTKSSILLHKELDSRS-------K-KAVREYLYRVNEAIAVLYARHV
LASLLAEWPDDVAINEEILDLSGPAHMTYILDMLMQLEEKQLWEKILQKVLHGCKESMLG
TMALTACQFMEEPGMAVQMRESQHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LLMSSSSDFQQDRHSFSGSPQKWTDFELPGE-----------------CTDSRLSSIFI-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCPLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEEH
RSE-ATEANPESL--AKECIEKSLLLLKFLPTGICSKESCDKLETADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQALPATAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPADFKQRS---KAD-KGVS-LTKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAGAAGGEGW-SP-HQDWAADSGTTP-----------
GPGPAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFREVLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDVHSSMILRFLHRNRL
SSTVVPYPMLDHCNNMCTMRASVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-

PF03256 // ENSGT00890000139411_0_Domain_1 (294, 429)

KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASELQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFA---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTVSDHLDTHYDAASLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRVGCSPDDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IVCAHCRKDAEESVCGATLLLRTLQFIQQLAHDL--VQQKGSGLKYKSFLDFTGLDLQIF
WNFYSKLKENPREECVCAQTLLLQLLQSCFSVLQGDVPAASEDAKAPRQSPGQ----VEA
AKELYAHLCD-------VVDRVDGDSVPMELLKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNV-TEQNTSNP-------CSS------------------------------------
-------------------------------LSAHC-----------------AHILDVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTELLKELCSDPDG-GLNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNVAI
PQAKMALVLNSPLWKPVFRHQIRPELGLEASWPTHPHQDNKEVKNIPDDPCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEDRR
GSE-AAEANPESL--AKECIQKSLLLLKFLPIGASSKESCDTLVTADETDHLQ--QPRDR
RQRTGSVAGEHFQASGSPTEAAPP-AAGD---RSPGLGVQLP----------PPPSSGPP
AADVSSATAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPAVKERYPVLRDVMD
FVKDQALSPESVVKVLSLRKAQACSILEVLRIAQCCSESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFGSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHVASA
-EDVDGEKLAPQARRSAAALRSRCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSPPE
---NQAPPVTAPTGTAEEQREKAAAQAAAAP-ADAGPLA--------------HCS-GKR
-DVPKEV-RPLDPKQRS---KAD-EGVS-LMKEPSCRTQTSDAAADACT----PTGLPDA
EN--SEA-SSQKPMEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TGPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVTKVLSAKHNLFAAGDS
-SLVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLIQKGGGQEGS-----DAQAQLSQYSQHFAFIASHLLQTS
VDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEVLSIMLYSSKKEINTLAEHGELEPDERGDQEEDV-ERSVSSPGEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPARCEQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LTLLKPLWQLFTQMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNVPSAYSDDDELEGPGEAG-AAPGAGPVAAGADAPGLHRSPGPEGS
PSAAAAG--GLPRAPALLEPGALREAAARLSPGATPSPSPASTSGASGRPQAALLRWLEE
RR------IRGDIVVSVEQLREALEARGAGDEA--EERPQVVGQFEAEGDGTVDVETALE
ALKSAR-GASLPG--ELSHVTRQLQACPLVPGFVDIFAEAREGLGAHCSLILRFLHRHRV
ASAAIPYPLLDYCHTISALRSLVLKEALERLARRDK-EGPGELGGGQEAEQL-KSVAKCY
AYIETSSNSID

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGDTASFWQSD--GSARSHWVRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTVAVGRSANSLQEVRDVHIPSNVTGYVTLLENANISQLYVQINVKRCLSDGCDT
RIRGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVRRGGVSVSDASAIWYWSL---LTSLVTASMET------SPAFV---Q
TVLQNTQKALQHMPPLSLSPASTEGASFLSPSVLGEVDSFLVRITSCSAKPEVELTLLAF
ALARGSIAKVLSSLCAITDRLDTPYQASGLLSSMAAVRQNLLYKY---GRILQPTLQACD
VKGKGEKSGPENLLAEPWTGD-GFLTETGKTRASVIFSTGTEAAFQVTQLRIKVRRGGIG
AQCGLLFAYNSA-SEKFHAEEHFKRFEKYDTWKLPEFRQFLKSRMGNSSTDLGEDEPAGW
FEAEEDWDEVEVKMNCCRVAKYLMVKFLCTRRETAERLGVQGLSVYGYVRPAAAELGT-G
TACARCEPEA-DRICGMTLLLRTLSFIQQLAQDL--ARQKESGLKHKPLLDTAGLHLQLF
WSFYSRLESRPREECVLARTLLLQLLQSCLADLTADPPPPAGQGCPPGERPESRRRAQAA
PEELYAHLCQ-------VVDQDAADSLPARRLQEEVRNTLLQGAAVFFPDGHARRRHLFA
MMKNVTEQEQKPSAHLTFRSLCAYFSGCDPGGLLLLPDKGGSEGLDVQEALAVMDTLQAA
AARECDALMLGTAQGESSPALFSLFWSVQGSLLSWCYLQFKGNEPHAKRLAAEVVERYVG
QFLASVRRALRSLLSRYSGKEVVERLCNSVFAMATRQLVIFLLDFCTLDLPHLTLLKEFS
TLTEPLKSLCGDPDGGGPDRLDMETWQR-EQPVVLNTWSMESAHNYENNCHEVAVFVSPG
ATSFEVVFDDKCETETRYDYLEFTDARGVKTRYDTKVGTDKWPKKVTFRAGPRLHFLFHS
DSSNNEWGYKFTVTAYGLPDVAISWGLDLQLLVSRLMGRLASQCLSLKPD--HLGSDGGL
PPAKVAAVLHSPLWKSVFRHQLCPQEVPGACGPSLPAPGGKESPSARADACRDVLLDFAT
AAPAPASGGRSSELVQGLAQACRRQAPQTDRVAGSAVDGAVNATFAALVYLTPPLYEKLQ
SYVSSGGQLALSEDFAQVYALADGIRIWML------------EMKQKFLLDQGDEVEGEP
GAE-MREVNPENL--AKQCVQKSLLLLRFVPKGAGPRGGPRDRLARQDEAAPL--QPQGA
GQKAACVVEEYFQASEGSPAPGPESPSPG---GPPKKGHDSP----------FQQAEPSP
AACGNLLPEDVASPPSTPTRKPGFSRGRLRLLSFRSM--EEARPVATVTEKYPCLKDVMD
FIKDQTLSHESVLKVLSLKKAQAQGILDVLKTSQQCLEPLGQPHCFHAACLLFLLELLSC
QKDLADYLEHLEGCGAELHTEIRRSYHQLVRFLVDAVKGFGKLDDSFPRGLSPPLSEVRG
GLCSLLLGNGGEPSDLPFLVDIQLPELLMTMSQENISLHDSVICQWSEEDEIADYKQTSE
WMDECQDGMFEAWYEKISQMDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCHDMDLCKTCFLG--GVKPEGH

ENSGT00890000139411_0_Linker_2_3 (1944, 1952)

EDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEYACDHCQGVIVGRRVNCNVCDDFDLCY
GCYSAKKFSDSHLPSHGITVYPMVTIRTSDHQRLIQPYIHNYSWLLFAALTLYTADLAGG
-GEGEGQRLGAEDHQAAATLRDQCLELIGDCLVKAQRAKDRGPQSPHLLCMLPDGELPSE
---NETVPKSSSRDGATEMKDKASAVSST-----V--VP--------------TSGDGAS
-PLNKEV-SPVNFLNNS---T-SLLGVL-IFIDTLCQEKSLPSPHS-PPPPPSPPGPQ--
PY--GGA-SSLETVEENVTALSPEQVFAECSQKRILGLLAAMLPPLQSGS--TISWANLD
HILPLMFQVVISNAGHLNETYHLTLGLLGQLVVRLQPAKVDAAVSEALSAKHTLLSAGDG
-SASPEGWKTVHLLFSLGAVCLD---SRVGLDWACSMADILRALHACPQWHSVVAAFTDH
CMKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGARSVYLDNANEPHDVIVLKHFTEKS
RVVVVDVKTRKRK-TVKDCQLVRPSGPGSA------AERAPLHAQLPYFTFISSRLLQDG
LDQGYPEAVEATWVLALALKGLYRTLMAHSFEE-IQAAFLESGLLKLLVKKCSRGTGFSK
TWLLRDLEILSVLLYSSKREMSGGTEQEAGA----------GPPQPGSPPGDVGQSKPDP
LEGLDEAT---KVCFLMTH-DALNAPLPILRAMYELQMKRTDSFFLEVQR-RFDGDVIAT
DDRIRALAQKWQPRKRPRLEELSARAVDTDMIVLPCWSRPAACDQAAEESDPVTQKLIAG
TESDLRLSYAKQRRAKSAGLLHKELGARA-------KGAATRAYLHRVNEATAVLYARHV
LASLLAQWPEPVPITVDVLELASPAQMAYILDTLMQLEERQLWEKILEKALLGCSHDMLG
PVALTACQFMEEPGTAVQVCESKHPYSNNTTFEDKVHIPGAIYLSVKFDPQCSTEEGCDE
LAVASSSDFQQDRHSFSGSKQKWTDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKKMLSEERVVPHLPLARIWEWQVGVAC-RQTGHQR
LKAIHLLLKIVQCSTPSDLCD-LTLLKPLWKLFAQMEKGLCQDVGQSSVL-LPLHRALTE
-LFFVTENRVQELGSLQDYLLAL-----TTDDYLLCCTAQALRNIAAISLAINYPNKSTS
VWT---

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKDCIEKSLLLLKFLPTGIRSKESCDKLETAEET-NHL--QPLEK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDAYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSIPE
---DQALPATAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPADFKQRS---KAD-KGVS-LTKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPISSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTPG----------
-PGVAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDIHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTISDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVR-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-SHL--QPLNK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSSPE
---DQALPVTVPTGASEEQLEKKAVQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LSKDPSCQTQISDSPADASP----PTGLPDA
ED--SEV-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSRAQLSQYSRHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDYFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
SMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
---------------------RLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ENPGELTRSPEMD

PF03256 // ENSGT00890000139411_0_Domain_1 (291, 429)

KL-KSVTKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTIAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSADFSTFLSPNVLEEVDTKLP------------------
----------------------------------------SFLWS---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFNAEEHFKRFEKYDRWKLQELRQFVKHRAGCSSEDLGEGVPIGW
VELEEERDETDVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILCAHCKKDT-ESACGATLLLRTLQFIQQLAHDL--VQQKKSGLKYKSFLDFTGLDLQIF
WKFYSKLKQSPREECICAQTLLLQLLQSCFSVLQGDVPTASEEGKPPAQHPER----VQA
AKELYTHLCD-------VVDKVDGDSVLVEILKQEVKKTLLNGAAIFFPDRQTRRNHLFT
MMKNITEQEHKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLAGMNIGEVLAVMNTLLSV
AARECELLMLSEAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDL----------
AFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCSLDISHCTLLREFS
TLTELLKKLCNDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNLAV
PQAKMASVLNSPLWKPVFRHQICPGLELEASWPTHLHQNEKEVKKIPDDPCRRFLLDFAQ
SEPAQNFCGPNSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKL
SSE-AVEANPESL--AKECIQKSLLLLKFLPMDKSSEETFDKLVTV-NETDHL--QPLDR
HQRTSSVVEEHFQASASPTEAGPS-TAGD---NSPDWEVPSK----------LPPSSGPP
SAEVP--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPLPTVKEKYPVLKDAMD
FIKDQSLSYDSVVKVLSLKKAQAKSILEALRVIQYCTESLGQPHCFHPPYVLFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKTKD--------------------LT
ALL-HLLDMGCEPCDLAFFVDIQLPDLLMKMSQENISVHDSMISQWNEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHVTST
-EDMDGEKLGPQARSSAAILRSQCMQLVGDCLMKAHQGK--GLKTLALLGILPDGDSTPE
---HQALPITVSTPTSEEQLEKKTTGSLVQC-----------------------NCSGL-
----------FLYAYI----------------------------KT-GKSENLVFCHIDA
EI--SES-SSQKPIEEKAVTPNPEQVFAECSQKRILGLLAAMLPPAKLGP--TLPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNL------
---------------------------RVGLDWACSMAEILRSLNNAPLWQDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYIDNANEPHNVIILKHFTEKN
RAVIVDAKTRKRK-TVKDYQLTQKGGGQECN-----DSETQLSQYSQHFAFIASHLLQTS
MDSHCSEAVEATWILSLALKGLYKTLKAHGFEE-IHATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEVRNKAPPPSTA-----------------------TQGS--S----------P
SRGLLNLS----SCMFILC--------------------------------R-----ISV
DNLILLPSP---------------------------------------------------
---------------------------------------------------------RWI
FPVVAMDFPGQVPASGRLCLFPPETTDKPC---L----YPLASCQILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDFFNELKQFH---------QTHLSCFP
LLPL--------------CPAFSLLLHDPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWLLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTDDHLLRCAAQALQNVAAISLAINYPNKATH
LWNVEC

------------MGNAPSNSSEDEAAAAGGEGW-NP-HQDWAADSGTTP------GP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGSDSAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SNKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILYAHCRRDT-ENIHGATLLLRTLQFIQQLSHDL--MQQKESGLKHKSFLDFAGLDLQIF
WKFYSKLKQNRREECICAQTLLLKLLQSCFSVLQGDPQAASEEEKPAAQRSEG----IQA
AKELYTHLCN-------VVDRPNGNSMPMEILKQEVRNTLLNGAAIFFPDRQTRRSQLFT
MMKSVTEHERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLATMNTSEVLAVMNTLLSV
AARECELLMLNRSHGAVGSVLFSLFWSVQGSLLSWCFLQLKSTDAAAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFISPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
SQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHPHKDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALTEEFSQVYSLADGIRIWML------------EMKQKSLLSLGNDSEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPMSKSSKENCDKLETV-DETDHL--QPLDR
RQRTSSVVEEHFQGSASPTEAA-TPAAGD---RSPALEIQPK----------LLPSSGPS
VAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPIPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQGQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHREIRDTYYQLVLFLVKAIKRFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYTAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EQMDGEQLDPQARTNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTVSFQASEE------------QADAG--LL--------------VPCNGKR
-AADKEV-RPLDYKQKK---KA-GEDLS-IMKDPSCQTQVSDAPAS-AHV---PPGLPDA
EH--PEV-SAQVPVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSAKHNL------
---------------------------RVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQSQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEE-LDRPVSSPGEAEQKKLDP
LENLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSDQATPESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AIRDYLFRVNEATSVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLALGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LGLLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

----------------------HSTAAAGGEGW-VP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLDTHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLRESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARTEAEQ-S
ITCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKTPIQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYNGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
ILTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGRIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEANPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-SHL--QPLDK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---WSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDNHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDASPE
---DQALPVTVPTRASEEQLEKKAVQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LTKDPSCQTQISDSPADASP----PTGLPDA
ED--SEV-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLAQW-LT-----HVIPALWEAEA--------------GRSVELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPVRCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYGLFEDVTCTAHL-VLS------
--LTAPALSLQELGVLQDYLLAL-----TTDDHLLRCAAQP---------AINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWATVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGGSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTVTDHLDTQYDASSLLLSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFYAEEHFKRFAKYDKWKLQELRQFIKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEKEKAPTQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKEEVRNTLLNGAAIFFPNRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLANMNISEVLAVTNTLLSV
AARECELLMLSGAPGEAGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDIAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALIGLLKKLCGDPEG-GLTKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMAI
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPHQDSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSAGRIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSMGNEAEGKR
SSE-ATEVNPESL--AKECIEKSLLLLKFLPMGISSQESCNKLVTADET-NHL--QPLDK
RQRTGSVVEEHFQALVSPTEAAPP-ATGD---RSPGLDTQPR----------LLPNSGLP
AADVSPAAAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSIVKVLALRKAQAQGILEVLKITQYCAESLGQPHCFQPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAGA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILP------E
---DQALPATVPTQASEEQLEKKAVQGAERSEAG--PSV--------------HC-NGRR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LMKDPSCQTQISDSPSDACT----PTGLPDA
ED--SEA-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPSEVDAAVIKVLSAKHNLFAAGDT
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLDSTPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMSALAEHGDLEPDERGDREEEE-ERPASSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQQWQPSKGLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
PMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLLEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCATQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MLE
ALKHSS-GANLQG--ELSHTIRQLQACSLVPGFIDIFSESKEGLGVHASLILRFLHRNRL
SGTAVPCPMLDHCANVCAMRASVLKESLDQLLQREK-ESPGDLTGSPEMDKL-KSVAKCY
AYIETSSNPAD

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQDVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTISEHLDTQYDASSLIASMASVRQSLLLKY---GKPLQLILQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRAGCPSEELGEDDPIGW
FELEEEWDEADVKLRQCRVAQYLMVKFLCTRQESAERLGVQGLSISGYLRPVSAEAEQ-P
AVCTLCRKDGEDSICGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLRLLQSCFSMLQRDGPAACPQAKAPRQSPAG----AMA
AKELHTHLCD-------VVDRVDGDSAPMETLKQEVRNTLLNGAAVFFPDRQSRRDHLFA
MMKHVTEQEHKQSLQLTFRSLCAYFSDKDPGGLLLLPEKGDVADLNSPEVLAVTSTLLSV
AARECELLVLTGAQGEAGSVLLSLFWAVQGSLLSWCFLQLKSADPAARGRAADLLEQYVR
QFLASLRVILESLLSQHSGKTIVEKLCNSVFSMAARQLVIFLLDFCALDIPHCTLLREFS
TLTGLLRRLCADPEG-LLDKLDAETWRQ-ECPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWALDLQLLVSRLMGRLAAQGMALKSVH-QFGSDMVV
PPAKMASVLNSPLWKPVFRHQLSPELGLAASWPTPPHQDSKEVKNIPDDPCHHFLLEFAQ
SDPAQNFCGPFSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVCRTPGLYEKLQ
KYVKSGGSTALSEEFAQVYCLADGIRIWML------------EMKQKSLMTLGDEAEGRR
GSE-AAEVNPEGL--AKECIQKSLLLLRFLPVGVSSKESCDGLVAA-DETDHL--QPRDR
RPRTSSVVEEHFRASVSPVEVGTP-AAGD---GGPGSDVQPK----------LPPSSGPT
AADLSSATTEEPLSPSAPARRPPFARGRLRLLSFRSV--EEARPAPTVKEKYPVLKDVLD
FIKDQSLSHDSVVKVLALRKAQAQSVLEVLRIIQYCLESLGQPHCFHPPYVLFLLELLTC
QKEFTNYFVHLEGCGARLHKEVRDTYYQFVLLLVEAVKGFHSIHD---RSLLPALSCVQT
ALL-HFLDMGWEPGDLAFFVDIQLPHLLMKMSQENISVHDSVISQWSEDDELTDAKQNSE
WMDECQDGMFEAWYEKIAQEEPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1951)

HGDDHEMV

PF00569 // ENSGT00890000139411_0_Domain_3 (1951, 1992)

SMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSVTAHPMVTIRISDRQRLIQPYVHNYAWLLFAALALYSAHLASG
-EDAAGERLGPREHSSASALRSQCLQLAGDCLMQAHQGK--GLKTLCLLGILPDGESGPD
---RWAPPVTVPSRALEED---RAVRAVEDPLHAG--PS--------------VLCHGKR
-DGPEEV-GPLDSKQAS---KADEEGVS-LAKGPLCQTQASNSPAD-GGT---APRRPDA
EN--AGV-LSQKPLEEKAVPASPEQVFAECSQKRILGLLAAMLPPLKLDP--TVPVMPLE
RVLPLMFQVVISNAGHLNETYHLTLGLLGQLIARLSPAEVDAAVVTVLSAEHALFASGDS
-SVVPDGWKTTHLLFSLGAVCLD---SRMGLDWACSMAEILRLLSSTPQWRDVIATFTDH
CVKQLPFQ--LKHTNVFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIVLKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKG--QGCG-----GSQARLSQYAQHLAFIASHLLQTS
VGSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKESHTSAEHTALERDERGDPEDEV-EGMVSSPTEPEQKKLDP
LESLDEPT---RICFLMAH-DALRAPLHVLRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSGGLRLEEQSAKAVDTDMIILPCLARPARCEQATAESNPVSQKLIAS
TESELRQSYAKQRRSKSAALLHKELNSKS-------KR-AARDYLFRVNEATAVLYARHV
LASLLADWPGHVPVSEDTLELSGPAHMTYILDMFMQLEEKHQWEKILRKVLQGCRGSMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSVKFDPQCSTEEGCDE
LAMASSSDFQQDRHTFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWQLFTHMEYSRLEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATG
LWNVEC

------------MGNAPSNSSEDEAAAAGGESW-SP-HQDWAADSGTTP------GP-GP
GPGPAAA--ALPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKESLGTHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLVRSPEMDKL-KSVTKCY
AYIE

PF03256 // ENSGT00890000139411_0_Domain_1 (305, 429)

TSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQQYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLVRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTRYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SAKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ILCAHCRKDT-ENICGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQSDPPVASEEEKPAAQCPER----MQA
AQELYTHLCD-------VVDRADGDSMPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFT
MMKNVTEHEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLANTNTSEVLAVMNTLLSV
AARECELLMLSRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTDTTAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRFDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMVV
SQAKLASVLNSPLWKPVFRHQICPEVELEASWPTHPQHNRKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKITLSEEFSQVYSLADGIRIWML------------EMKQRSLLSLGSETEEKR
GLE-AVEVNPESL--AKECIQKSLLLLKFLPTSKSSKENGDKLVPVVDEPDHL--QPLDR
RQRTSSVVEEHFQASASPTEAA-TPTTGD---KSPGLEIQPK----------LPPSSGSS
GAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPCILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EHVDGEQLDPQARSNAAVLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTVSIQTSGEQLEKKTVQLAEEPADVG--LF--------------VTCNGKR
-ATDKEV-RPLDYKQRK---TA-TEGLS-LTKDLSCQTQTSDAPAS-A---PVPPGPPDA
EH--PEV-SSQTPVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIQSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDTAVVKVLSAKHNLFATADN
-GIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQAQLSQYSQHFAFIATHLLQTS
MDSHCSEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTEHGDLELDERGDQEEE-VDRPGGIPGESEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPVRSDQATAESNPVTQKLIPS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDFLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCREGMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAATGGEGW-GL-HQDWAADSGTTP-----------
GSGPAAP--ALPPAPALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCTG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALKN

ENSGT00890000139411_0_Linker_0_1 (185, 278)

SS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEG-GVHSSMILRFLHRNRL
SSTVIPYPMLDHCNNVCTMRASVLKESLDQLVQKEK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLHEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPSSV---Q
TVLRNIQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTPYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGNESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRISCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRIAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IICAHCRKDVEESVCGATLLLRTLQFIQQLAHDL--VQQKESCLKYKSFLDFAGLDLQIF
WNFYSKLKQXXXXXXXXXXXXXXXXXXXXXXXXXXXASAASEDEKAPCKSLRG----AED
AKELYTHLCD-------VVDRVDGDSVSMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMXXXXXXXXXXX-XXXXXXXXXXXXDKDPGGLLLLPEKGDLADMNISEVLAVMSTLLSV
AARECELLMLNGAQGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVE
QFLAHMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDTRGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQISPELGLEASWPTHPYQDSKEVKNIPDDSCHHFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALTEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
GSE-AAEANPESL--AKECIQKSLLLLKFLPMGISSKESCDRLVTTNET-DHL--QPLDK
RQRTGSVVEEHFQASASPSEATPP-AAGD---RSPGVDVQVK----------LPHSSGPL
ATEVSSATAEEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCAESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAIKGFSSIND---RSLLPALSCIQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XLKALALLGILPEGDSTPE
---NQAPPVTVPTRTSEEQLEKEAVQGAEEL-SDLGPFV--------------HY-NGKR
-ISYKEV-RHLDRKQKN---KAD-GSVL-LMEDPSCQSQISDLSADAST----PTGLPDT
EN--SEA-SSQKPIEEEVVTPNPEQVFAECSQKRILGLLAAMLPPLKSDL--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLILRLLPAEVDAAVIKVLSAKHNLFAAGDN
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKG-GQECS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAEHGDLELDERGDQEEEV-ERSVSSPSEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPWHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPXXXXXXXXXXXXXXXX---------------
--XXXXXXXXXXXXXXXXX-XFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCSHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQV---------------------------AALQNIAAISLAINYPNKATH
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHTIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNS

PF03256 // ENSGT00890000139411_0_Domain_1 (310, 427)

ADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKHKSFLDFAGLGLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKECIEKSLLLLKFLPTGIRSKESCDKLETADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQALPVTAPTQASEEQLEKKTVQGAELSEAGNDPGI--------------TCDNGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LTKDPSCQTQISDSPTDAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDQEEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QAFAQFDAEGDGTVDVENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRI
SSTAIPYPVLEYFNNICTMRSSVLKDSLDRLLLKER-EYPSDLNGN

PF03256 // ENSGT00890000139411_0_Domain_1 (287, 446)

QELDKL-KSVTKCY
THIETSSNSADIDKMTNGETTSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVAVGRNASSLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLRAIGYQRVKKVGVSVCDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---H
TILQNTQKALQHMPPLSLTPGSTDFSSFLSPNVLQEVDSFLIRITSCCTTPEVELTLLAF
ALARGSVAKVISSLCTITDHLDTPYKASSLIASMATVRQNLLYKY---GKPLRLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASIILSTGTESSFQVTQIRIKVRRGAIG
AQCGLVFAYNSA-SEKFHAEEHFKRFERYDKWKLQEFKQFLKNRSSCSSDDLGDDDPVGW
FEVEEEWDEVDVKMQQCIVSQYLMIKFLCTRQDTAERLGVQGLSVLGYLRPMREEPNR-S
MNCLQCRKTGDDTVCGTTLLLKTLHFIQQLAQDL--VHQKESGLKYKSFLDFTGLDLQLF
WNFYNKLQQNPREECIFAQTLLLQLLQSCFSVLTGDNKIAKPQETSQ----NKTPGHTEA
AEELYRHLCE-----GAVVDMGDSNLMPVKMLKQEVKNTLLSGAAIFFPDRQTRRNQLFT
MMKNITEQEHKQSVHLAFRSLCTHFSDQDPGGLLLLPEKGVSADFDISEVLSVMETLLLV
AARECEMMMLDVAQQESGTVLSSLFWSVQGSLLSWCYLQLKGSDNSAKDLAVEILKNYVG
QFLSNTRRILQSLLSQYSGKTIVEKISNSVFAMATRQLVIFLLDFCTLDIPYCTLLKGFS
TLVEPLKNLCSEPHK-GILKMEMESWQQ-EQPVVLRTWTMESPHNYENNCHEVSVFLCHG
ATYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFSVTAYGLPDVAVSWGLDLQLLVSRLMGRLASRSMALKSLR-ELGSEADL
PPLKVTSVLNSPLWKPVFRHQMCPEAIPGASQTSRLHQNKKEARNSHQDDCRNFLIDFAK
SDPAQDFSGQKSELFKGLIQACKKQTPKTDIVAGSTVDQAVNSTFAALVYLTPDLYEKLQ
KYVNSGGKVPLSDEFAQVYSLADSIRIWML------------EMKQKSLMARGNDTEEKQ
NTE-ASEVNPETL--AKLCMQKSLLLLNFLPVRAKTKSSSD-------SSE-VQDIVSDK
CQRIGSVVETDFQAAPSLSSSRVTHPVSIERGQITQSDTKT----------------NKP
AENATSQQEDVSSPPSTPTRKSQFSRGRLRLLSFRSI--EEPRPVPTVKEKYPILKNILD
FIKDQSLSHESVLKVLALRKSQGQSIMEVLKTIHQCLDSLGRPHCFHPSCVLFLLELLAC
QKDFTNYFGNLEGCGAELHKEIRESYYQLVLFLVNSVKGFSTIND---RSLLPALSCVQT
TLL-HLLDMSWEPSDLSFFVEIQLPQLLMTTSQENISIHDSVICQWSEEDEIADYKQNCE
WMDECQDVMFETWYEKIAQADPEKQRKMHMFVARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1945)

LNVDISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPEGHE

ENSGT00890000139411_0_Linker_2_3 (1945, 1950)

DDHEM

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEYACDHCQGVIIGRRMNCNVCDDFDLCY
GCYSAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLANG
-EEVEGEKLDSQVLSHARVLQHQCIQLIGDCLMKAQHGK--GLKNLALLCMLPEGESFSE
ND---TVSVSPPTDGAPKS-CVGD-----K--EVKGKDE-KPSG--------------KR
DTH-NEIQSPAEDKVQKQGSESNHSAVL---AKKAVLRQESDLSVDDNAS---PTE-ADD
CT----SEDSAQKQAEKVLIPSQEQVFAECSQKRILGLLAAMLPPFKSGS--TMSLINLE
QILPLMFQVVISNAGHLNETYHLTLGLLGQLILRLMPAEVDAAVAKVLSAKHNLFAAGDG
-STMPEGWKTTHLLFSLGAVCLD---SRVGLDWASSMADILRSLNSSAQWHNVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGTRSVYMDNANEPHNVIILKHFTEKN
RAVVVDIKTRKRK-TVKDYQLIQKCGQEGSDS------QTQLRQYLQHFVLISTHLLQTS
MDSSYAEAVEATWVLSLALKGLYRTLKIHGFKE-VQAAFLQSGLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISSLAEREDTELEEREQDQDV-EQ-SVVGSADLEQNKLDP
LEGLDEAT---KICFLMTH-DALNAPLHILRAMYELQMKRTDSFFLEVQK-RFDGDVITT
DEKIRTLAQKWQPSKRLRLEEQSSKAVDTDMIILPCLSKPVLCDKATEETNPVAQKLITN
TESDLQLSYAKQRRTKSSILLHKELDSRS-------K-KSVRDYLYRVNEATAVLYARHV
LASLLAEWPDDVAINEEILDLSGPAHMTYILDMLMQLEEKQLWEKILQKVLHGCSGSMLG
TMALTACQFMEEPGMAVQMRESKHPYNNNTNFEDKVQIPGAIYLSIKFDSQCNTEEGCDE
LLMSSSSDFQQDRHSFSGSPQKWNDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQTAGFEILKQMLSEERVVPHLPLAKIWEWQVGVAC-RQTGHQR
LKAIHLLLKIVQCS-AQRDCD-LTLLKPLWQLFTHMENNLCHDVTKPGIL-LPLHRALAE
-LFFVTENRVTELGSLQEYLLA---L--NTEDHLHRCTAQALKNIAAISLAINYPNKSTS
FWNV--

------------MGNAPSHSSEDEAAVAGGEGW-GP-HQDWAAELGTIP------GA---
--GPAGP--ALPPASALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALKNST-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVRKEK-EGPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXX------XXXXX---X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXLSPSVLEEVDSFLIRITSCSSTPEVELTLLAF
ALARGSVAKVLSSLCTIVDHLGTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSSGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQEFRQFLKSXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X
XXXXHCRKDA-ESVCGT--LMKTLKFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLKIF
WNFYSKLKQXXXXXCICAQTLLLQLLQSCFSVLQGDALAVSENEKAPNQSPEG----VEA
AKELYTHLCD-------VVDRLDGNSVTMI--LQQVRNTLLS-TAIFFPDRQTRRNLLFT
KMXXXXXXXXXXX-XXXXXXXXXXXXDKDPGGLLLLPEKSDLADMNISEVLAVMNTLLSV
AARECELLMLSGPRGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDTGAKDLAVDLIEKXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXLDVETWQQ-EQPVVLHTWTKESAHNYENNCHDVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPQLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVKNIPDDPCCTFLLDFAQ
SDPAQSFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKAALSEDFAQVYSLADGIRIWML------------EMKQKSLMGLGNELEEKH
NSE-AKEANPESL--AKECIQKSLLLLRFLPMGVSLKESSDKLVTA-DETDHL--QPLDK
RQRTSSVVEEHFQASSSPTEAAPP-ATGD---RSPGLDVQTK----------LLPSSGPP
TTEVSSATSEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPILRDVLY
FIDQS-V-SREVVKVLSLKKAQAQSILEVLKIIQYCAESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGAELHKEIRDTYYQLVLFLVKAVKGFSSIND---XXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--GVKPEGHGDDHEM

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRFIQHNIHNGEV---PALPLTSKRAASA
-EEEVVEKLHRRDRSRADTLRGQCVPVMGASLMRARGKX--XXXXXXXXXXXXXXXXXXX
---XXXXXX-------XXXXXXXXXXXXXXXXXXX--XX--------------XXXXGKG
-EVHEEI-RPLDCKQKN---KVD-ESVP-LIKDPSSQTQISDSSAD-AGT---PTGLSDA
VY--SET-STQKSVEEKALTPSPEQVFAECSQKRILGLLAAMLPPL--GP--AVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIHLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIMPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVVATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIVLKHFTEKN
RAVIVDIKTRKRK-TVKDYQLVQKGGGQECS-----DSETQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLSLKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAERGDLGLDDRGDQEEEV-ERAVSSPSEPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHVLRAIYELQMKRTDSFFLEVQKXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXXXXXXX-------XX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKIHIPSAIYLSIXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCNHSDLCD-LALLKPLWQLFIHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQXXXXXXXXXXXX-----XXXXXXXXXXXXALQNIAAISLAINYPNKATQ
LWNVEC

------------MGNAPSYSSEDESAAAGGEAWS--LHQDWAVDSGTAP-----------
--SPGPVAPALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGARCSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

QFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESREGLDVHSSMILRFLHRNRV
SSMVIPYPLLDHCNNVCTMRSSVLKESLDQLVQKEK-ENPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADVDKMTNGETSSYWQSD--GSARSHWIRXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKPGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLQNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYEALSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSSGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRIAK---------------------------------------
------------------------------------VQQKESGLRYKSFLDFVGLDLQIF
WNFYNKLKQNPREECICTQTLLLQLLQSCFSVLQDDVAVSEKEKSP-----KQIPKKMEA
AKELYTHLCD-------VVDGVSGDSVPMETLKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXCELLMLNGAQGEVGSVLFSLFWSVQGSLFSWCYLQLKSTDTGAKDLAVDLIEKXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMSLKSIH-QLRSSMAV
PPAKMVLALNSPLWKTVFRHQICPELELEA-HPTHPHQDSKEVKNIPDKPCRDFLLDFVQ
SDPAQNFCGPYSELLQGFIQACRKQAPKTDVVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALGEEFAQVYSLADGIRIWMX------------XXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXX--XKECIQKSLLLLKFLPMGISSKESYDKLVTAVE--THPLQ-PLDK
RPRTSSVVEEHFHASASPTEAAPLAVAD----KTLGLDVQPKLL---------LPSSGTS
TAEVSSATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHDSVVKVLSLKKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLAC
QKEFTNYFGHLEGCGAELHKEIRETYYQLVLFLVNAVKGFSRLND---RSLLPALSCIQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFACDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYVHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQARSSATTLQSQCVQLVGDCLMKAHQGK--GLKALALLGMLPNGAPTPE
DQ---SLPVLPPTHASGEQLKRTAVQAAEEPSEAGGKDASHKETRPLD-----CRQKDKA
DERMSIMKDP------------------------SCQSQTADTAADTGTSR----ALPDA
E---DAEASSRKPVEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVHLIDLE
HVLPLMFWVVISIAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFASGDS
-SAVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGEQECSD------SAQLSQYSQHFAFIASHLLQTS
MXXXXXXXXXXXXXXXXXXXXXXXXXXAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX
XXXXXXXX---XXXXXMAH-DALNAPLHVLRAIYELQMKRTDSFFLEVQK-RFDGDELTI
DERIRTLAQRWQHSKSLRLEEQSAKAVDTDMIIMPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHMPVSEDILELSGPAHMTYILDMFMQLEEKQQWEKXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXX--X
XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATL
PWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MLE
ALKNSN-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEQLGLHASMILRFLHRNRI
SSIVIPYPVLEYFNNICTMRSSVLKDSLDKLLLKEK-ESPSDLNGNQDMDKL-KTVTKCY
THIETSSNSA

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 427)

DIDKMTNGETLSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVAVGRNAINLQEVRDVHIPSNITGYVTLLENANISQMYVQINIRRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGYQRVKKVGVSVCDASAIWYWSL---LTSLVTASMEA------NPAFV---H
TILQNTQKALQHMPPLSLTSGSTDFSNFLSPNVLEEIDSFLIRITSCCATPEVELTLLAF
ALARGSVAKVISSLCTITDHLDSLYKASSLISSMATVRQNLLYKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASIILSTGTESTFQVTQIRIKVRKGAIG
AQCGLVFAYNSS-SEKFHAEEHFKKFESYDKWKLQEFRQFLKNRSDLSCDELGEDDPVGW
FEVEEEWDEVDVKMQQCRVSQYLMVKFLCTRQDTAERLGVQGLTVLGYLRPTVVEPNR-S
MNCLKCKAT-DDGICGTTLLLKTLHFIQQLAQDL--VHQKERGLKYRSLLDFTGLDLQLF
WNFYNKLRQNPREECLFAQTVLLQLLQSCFSVLTGDNKT---QEVSQ----SKTSGQTEA
AQELYRHLCE-------VVDVSDSNFTPMTMLKQEVKNTLVNGAAIFFPDRQTRRDQLFT
MMKNITEQEHKQSVHLTFRSLCMYFSDQDPGGLLLLPEKEVSEDFDISPVLSVMDTLFLV
AARECEMMMLDIAQQESGTVLSSLFWSVQGSLLSWCYLQLKGSDNTAKSLAIEILKKYVG
QFLSNIRTILESLLSQYSGKLIVEKLSNSVFAMATRQLVIFLLDFCTLDIPHCTLLQGFS
ILIPLLKNLCSEPGE-SLNKVDLESWQQ-EQPVVLRTWTMESPHNYENNCHEVSVFLCPG
ATYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFSVTAYGLPDVAVSWGLDLQLLVSRLMGRLASRSMALRSQL-ELGSEAEL
PPSKVTSVLNSPLWKPVFRHQMCPEASLETNEPTQVHQNKKETKNSHADDCHNFLLDFAK
SDPCQDFYGQNSELFKGLIQACKKQAPKTDVVAGSTVDQAVNATFAALVYLTPDLYGKLQ
KYVNSGGKISLNDEFAQVYSLADGIRIWML------------EMKQKFLMGKGNDTAEKQ
NTE-TSEVNPEIL--AKHCIQKSLLLLKFLPERAKAKDPVSDNWDASALED-VQQYHDDK
RQRTSSIVEADFKAANSLSSNGVNHPPSAERSGVVDVDTKIKLMSDSSQTEVASESQSKP
LENTVSQQEDIASPPSTPTRKPQFSRGRLRLLSFRSM--EESKSVPTVKEKYPILKNILN
FIKDQSLSHESILKVLALRKAQAQNILEVLKTVRQCLESLGQPHCFQPPFVLFLLELLAC
QKDFSNYFGHLEGCGAELHKEIRESYYQLVLFLVNAMKGFNSISD---RSLLPALSCVQT
SLL-HLLDMSWEPSDLSFFVDIQLPLLLMTMSQENISIHDSVICQWSEEDEIADYKQNSE
WMDECQDIMFETWYEKIAQADPEKQRKMHMFVARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPKGH

ENSGT00890000139411_0_Linker_2_3 (1944, 1952)

EDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEYACDHCKGDIIGRRMNCNVCDDFDLCY
GCYSAKKYSDSHLPTHSITIYPMVTIRISDRQRLIQPYIHNYSWLLFAALTLYCADLASG
-DEVE-EKLDSQILSHARVLQHQCIQLIGDCLMKAQHGK--GLKALALLCMLPEGETLSE
NE---TTSVSPPIGGTTEV-YAKD-----K--VIKGTNK-KPRTSSFV------HCNGKG
DDVFGEIQSSINKQEKEESQNNLSNAHL---TKKDILRQDSEILALNSAGDSISLCLPGA
EN----SEDSSQKQAEKVLMPSQEQVFAECSQKRILGLLAAMLPPFKSGC--TISLINLE
QILPLMFQVVIANAGHLNETYHLTLGLLGQLILRLMPAEVDAAVTKVLSAKHSLFAGGDG
-STVPEGWKTTHLLFSLGAVCLN---SRVGLDWSCSMADILRALNASTQWHSVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGTRSVYMDNANEPHNVIILKHFTEKS
RAVVVDIKTRKRK-TVKDYQLVQKYEKESAES------QTQLRQYLQHFAFITSHLLQTS
LDSSYSEAVEASWVLSLALKGLYRTLKTHGFEE-TQAAFLHSGLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISSMAEHEDTELEERERDQDV-DQ-SV-SPIDLDQSKLDP
LEGLDEAT---KICFLMTH-DALNAPLHILRAMYELQMKRTDSFFLEVQK-RFDGDVITT
DEKIRTLAQKWQPSKRLKLEEQSSKAVDTDMIILPCLSKPVLCDKATEESNPITQKLITN
TESDLQLSYVKQRRTKSSILLHKELDSRS-------K-KAVRDYLYRVNEATAVLYARHV
LASLLAEWPDGVAVNEEILELSGPAHMTYILDMLMQLEEKQLWEKILQKVLHGCNESMLG
TMALTACQFMEEPGMAIQVRESKHPYNNNTNFQDKVHIPGAIYLSIKFDSQCNTEEGCDE
LIMSSSSDFQQDRHSFSGSLQKWTDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVIPHLPLAKIWEWQVGVAC-RQIGHQR
LKAIHLLLKIVQCS-NQRDCD-LTLLKPLWQLFTQMENNQCNDVSKPGVLLLPLHRALTE
-LFFVTESRVNELGSLQDYLLA---L--NTEEHLHRCTAQALKNIAAISLAINYPNKSTS
LWNV--

------------MGNAPSHSSEDEAAAPGGESW-SP-HQDWAADWGTTP------GP---
--GPAAP--ALPLAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEXXXXXXXXXXXXXXXXXXXX
XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX-XXX-XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXFKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTASDLQEVRDVHIPSNVTGYVTLLENANISQQXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXIWYWSL---LTSLVTAPMET------NPAFV---K
TVLHNTQKALQHMPPLSLSAGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVVSSLCTISDHLETQYEASSLLSAMASVRQSLLLKY---XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XFLTETGKTRASTIFSSGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSA-SDKFHAEEHFKRFEEYDRWKLKEFRQFVKSRIGCSSDDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARTDAEPSA
AVCAHCRKDSEESICGATLLLRTLQFIQQLAHDL--VQQKEGGLKYKSLLDFAALDLQIF
WNFYNKLKQNPREECIYAQTLLLQLLQSCFSVLQGDAQVVSEKQKAPKQRPER----MED
AKELYTHLCD-------VVDKVDGDSVLMDVLKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MM-NVTEQEHKPSQQLTFRSLCTHFSDKDPGGLLLLPEKSDLADMNINEVLAVMNTLLSV
AARECELLMLNGAQGEVGSVLFSLFWSVQGSLFSWCYLQLKSTDPVAKDLAVELLEKYVQ
QFLAKMRVILESLLSQYSGKIIVEKLCNSVFSMGSRQLVIFLLDLCTLDISHCTLLRAFV
PLTELLKKLGSDPEG-GLNELDVETWQQ-EQPVVLHSWTKESAHNYENNCHDVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCLALKSAH-QLGKDMAV
PQAKMASVLNSPLWKPIFRHQIYPEMDFEAHGPTCPPQDSKEVKTISDNPCRDFLLDFTH
SDPAQNLSGPYSELSKGVIQACRKQTPKTDIVAGSTIDQAVNATFAALVYCTPDLHEKLQ
KYXXXXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXLGNEAEEKR
NSE-ANETNPESL--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX
XXXXXXXXXXXXXX-XXXXXXXXX-XXXX---XXXXXXXXXX----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXKEKNPVLKDVND
FIKDQSLSHESVVKVLSLKKAQAQSILEVLRIIQYCAXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXYFGHLEGCGAELHKDIRETYYQLVLFLVKAMKGFSNLKD---XXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEDDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMLMFIARXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--GVKPEGHGDDHEM

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1993)

VNMEFACDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXX-X--
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX--------------XXXXEKG
-AAQKAV-GSTDCKPRK---KM-EAGVL-LMKAPPCQILTASSPAD-ASKPPG---HPXX
XX--XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXST--TLPLIDLE
HALPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVIKVLSATHNRLQSGDS
-SLXXXXXXXXXXXXXXXXXXXX---XRVGLDWACSMAEILRSLNSAPLWRDVLAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCIYMDNANEPHGVIVLKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECS-----DSQAQLSQYSQHFALIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYQTVKAHGFEE-THATFLHTDLLKLLVKKCSKGTGFSK
TWLLRDLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX
XXXXXXXX---XXXXXMAH-DALNAPLHVLRAIYELQMKRTDSFFLEVQK-RFDGDELAI
DERIRSLAQKWQPGKSLRLEEQSAKALDTDMIILPCLXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XX-AARDYLFRVNETTAVLYA-HV
LASLLAEWPGHVPVSEDVLELSGPAHMTYILDMFLQLEEKQQWEKILQKALQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LSMSSSSDFQQDRHIFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAQIWEWLVGVAC-RQTGHQR
LKAVHLLLKIVRCCTLSDLCD-LALLKPLWKLFTHMEYSLAEDVTQPGIL-LPLHRALTE
-LFFVTENRAQXXXXXXXXXXXX-----XXXXXXXXXXXXALQNIAAISLAINYPNKATL
LWNVEC

------------MGNAPSNSSEDEAAAAGGESW-GP-HQDWAADSSTTP------GL---
--GPAAP--ALPPAAALLEPARLREAAAALRPAPP-------YESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMD

PF03256 // ENSGT00890000139411_0_Domain_1 (291, 429)

KL-KSVTKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTGYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-N
ILCAHCRKDT-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLRIF
WNFYSKLKQNPREECICAQTLLLRLLQSCFSVLQGDALAASGEEKPPTQRPEG----VEA
AKELYIHLCD-------VVDRVDGDSMPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLADMNISEVLAVMNTLLSV
AARECELLMLSGTQGEAGSVLLSLFWSVQGSLLSWCYLQLKATDTAAKGLAVDLIEKYVA
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-GPNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSTY-QLGSNMVI
PQAKMASVLNSPLWKPVFRHQICPELELEASWPTHPHQDRKEVKSIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSRGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGSEAEEKH
SLE-ATEANPESL--AKECIQKSLLLLKFLPMAKSSKESSDKVATA-DETDHL--QPLDR
RQRTSSVVEEHFQASASPTETA-APTVGD---KSPGLEIPPK----------LPPSSGPP
TAEPS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSISNESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVMFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDNCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EVVDGERLDPQAHSNAIILRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---NQTLPLNVPTRTSE------------EQAEAG--PF--------------VHCKGRR
-AADKEI-RPLDYKQRS---KA-NAGIL-FMKDHSGQTHIPNVPAD-AHIPP---GFPDA
EN--SEV-SPQEPIEEKAVTPNPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDAAVIKVLSAKHNLFAAGDS
-AIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSYCSEAVEATWILSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAEHGELELDERGDQEEEV-ERPVSSPGDPDQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIFELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAMDTDMIILPCLSWPARCNQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVHCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AFAQFDAEGDGTVDAESMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRL
SSMVIPYPMLDHCNNMCTMRASVLKESLDELVQKEK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ESPGDLTGSPEMDKL-KSIAKCY
AYIETSSNPTDIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVASTDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDGSTFLSPNVLEEVDSFLIRITSCCSTPDVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTATESALQVTQIRIMVRRGGIG
AQCGLIFAYNSS-SDKFHAEEHFKRFEKYDKWKLKEFRQFVKSRIGCSPDDLGEDDPIGW
FELEEEWDEAEIKLQQCRVARYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
AICAHCRKDMEESVCGASLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLEIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFLVLQRDATAASEDAKAPRQSPRA----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLSGAAIFFPDRQTQRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDRDPGGLLLLPEKGDLADTNIGEVLAVMRTLLSV
AARECELLMLNKAQAEVGSVLFSLFWSVQGSLLSWCYLQLKSTDPGAKELAIDLIEKYVE
QFLGSTRSILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCKLLREFS
TLTELLKRLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQICPELGLEASWPTHPQQDSKEVKNIPDDPCHRFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGTTALSEEFAQVYSLADGIRIWML------------EIKQKSLVSLGNEAEEKR
GSE-AAEANPESL--AKECIQKSLLLLKFLSMGISSKESSDKLVTTDEPDHHL--QPLDK
RQRTSSVVEEHFQASASPTDTAPP-AAGD---RSPGLDVQPK----------LPPSSGPP
ATEVSSATAEEPSSPSTPTRRPPFTRGRLRLLSFRSMKPEEARPVPTVKEKYPVLRDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLKIIQYCAEALGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGAALHKEIRDTYYRFVLFMVKAIKGFSSIND--------ALSCVQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFETWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRSSDRQRLIQPYIHNYAWLLFAALALYSAHLASS
-EEVDGEKLDPRARSCAVTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGNSTPG
---NQAPPVIVPTRTAEEQLEKEAVQVAEEP-ADTGPFV--------------HCNSREV
-KSTDST-Q-ITWASHP---GAK-RS--------SEASRPRSGRSPARA----KTWVPDA
DN--LGA-SSQKPVEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKLDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPSEVDAAVIKVLSAKHNLFAAGDN
-SIMPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFSLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHDFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLESDERGDQEEEV-ERSVSSPSEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRALAQKWQPSRSLRLEEQSAKAVDTDMIILPCLSQPTRCDKATAESNPVTQKLISS
TESELQQSYAKQRRTKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAILYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYIFDMFMQLEEKHRWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVLCCNHSDLCD-LSLLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATC
LWNADC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAADSGMTP------GL---
--GPAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEXXXXXXXXXXXXXXXXXXXX
XXXXXX---XXXXXXXXXXXXXXXXXXXXXXXFIDIFSESREGLGVHSSMILRFLHRNRI
SSLGIPYPMLDHCNNMSTMKASVLKESLDQLVQKEK-XXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTPYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IICAHCRKDAEESVCGATLLLRTLQFIQQLTHDL--VQQKESGLKYKSFLDFTGLDLKIF
WNFYSKLKQNPRGECICAQTLLLQLLQSCFSVLQGDALAASEQEKAPAPNPEG----VKA
AKELYTHLCD-------VVDRVNGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLASMNISEVLAVMNTLLSV
AARECELLMLSGAQGEASSVLLSLFWAVQGSLLSWCYLQLKSTDSEAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKMIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTDLLKKLCRDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKIRYDTKVGTDKWPRXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XLGINMAV
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQDSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSAIDQAVNATFAALVYRTPDLYEKLQ
KYVHSGGKVALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEDKR
SSE-AAETNPESL--AKECIQKSLLLLKFLPTGMSSKESCDRLVAA-DETDHL--QPLDR
RPRTSSVVEEHFQASASPTEAAPA-TAGD---KSPGSGVQPK----------PLPRSSPP
IAEVSSATADEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPVPTVKEKYPVLKDVMD
FIKDQSVSHESVVKLL---KAQAQSILEVLRIIQ-CAESLGQPHCFHPPFI-FLLELLTC
QKDFTNYFGHLEGCGTDLHREIRNTYYQLVLFLVKAMKGFSNIND---RPLLPALTCVQT
ALL-HLLDVGCEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKXXXXXXXYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1943)

LNVDISCDGCDEIAP-HRYRCL
QCSDMDLCKTCFLX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XLKALALLGVLPDGNSTPE
---NQALPDIAPTRTSEEQLEKRAVQTAKEPSGAV--PS--------------VHGNDKR
-AVHKEV-RLVDYKRNR---ANEG--GP--LEKGTWQTQIPNSPAD-ART---PTGLPDA
EN--SDV-SSQKPVEEKAVTPNPEQVFAECSQKRILGLLAAMLPPLKSGP--SVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLITRLLPAEVDAAVTKVLSAKHSLFAAGDS
-AVVPDGWKTTHLLFSLGAVCLD---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX--XXXXXXXXXXXXXGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THSTFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISILAEHGDLELDERGEQDEEM-ERPVSSPGEPEQKKLDP
LEGLDEPT---RICFLMARSDALNAPLHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVREQ-HPYN-HTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQSGHQR
LKAIHLLLRIVRCCSLSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQXXXXXQDYLLAL-----TTDDHLLRCAAQ--------------------
------

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCPLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKECIEKSLLLLKFLPTGIRSKESCDKLETADDT-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVLD
FIKDQSLSHRSVVKVLSLRKTQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSNLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQALPATAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRS---KAD-KGVS-LTKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGTTP------GP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGSETAFQVTQMRIMVRRGGIG
AQCGLVFAYNSP-SNKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKFLMVKFLCTRQESAERLGVQGLSISGYLRPRRTEAEQ-S
ILYAHCRRDT-ENIHGATLLLRTLQFIQQLAHDL--VQQKDSGLKYKSFLDFAGLDLQIF
WNFYRKLKQNPREECICAQTLLLQLLQSCFSVLQGDSQAASEEEKPAARRLEG----IQA
AQDLYTHLCN-------VVDRTDGDSMPMEILKQEVRNTLLNGAAIFFPDRQTRRSQLFT
MMKSVTEQERKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLAAMNTSEVLAVMNTLLSV
AARECELLMLNRAHGAVGSVLFSLFWSVQGSLLSWCFLQLKSTDTAAKELAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
SQAKLTSVLNSPLWKPVFRHQICPELELEASWPTHPHQDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALTEEFSQVYSLADGIRIWML------------EMKQKSLLSLGNDSEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPMSKSSKENCDKLVPV-DETDHL--QPLDR
RQRTSSVVEEHFQGSASPTEAA-TPAAGD---RSPGLEIQPK----------LLPSSGPS
VAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYTAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EQVDGEQLDPQARTNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPVTVSCQASEEQLEKKAAQLSEEQADAG--LF--------------VPCNGKR
-AADKEV-RPLDYKQKK---KA-GEDLS-IMKDPSCQTQVSDAPAS-AHV---PPGLPDA
EH--PEV-SAQAPVEEKAITTNPEQVFAECSQKRILGLLAAMLPPIKLGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLQPAEVDAAVMKVLSTKHNL------
---------------------------RVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQSQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTELGDLELDERGDQEEE-LDRPVSSPGEAEQKKLDP
LENLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPARSGQATPESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLGKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LGLLKPLWQLFTHMEYGLFEDVTQTGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWATVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGGSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEALGVHSSMILRFLHRNRL
SSTVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAASDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLLLSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFYAEEHFKRFAKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEKEKAPTQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKEEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLANMNISEVLAVMNTLLSV
AARECELLMLSGAPGEAGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDIAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTGLLKKLCGDPEG-GLTKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMAI
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPHQDSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGRIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEGKR
SSE-ASEVNPESL--AKECIEKSLLLLKFLPTGISSQESCDKLVTADET-NHL--QPLDK
RQRTSSVAEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPR----------LLPSSGLP
AADMSPAAAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSIVKVLALRKAQAQGILEVLKITQYCAESLGQPHCFQPPFILFLLELLTC
QKDFTNYFGHLEGCGANLHKEIRDTYYQLVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTCSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILP------E
---DQALPATVPTQASEEQLEKKAVQGAERSEAG--PSV--------------HC-NGRR
-AVHEEV-RPIEFKQRN---KAD-KGVS-LMKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPTEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKLGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLDSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMSALAEHGDLEPDERGDREEEE-ERPASSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQQWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
PMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLLEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFAHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTPG----------
-PGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLDSHSSMILRFLHRNRL
SSAVMPYPMLEHCNTVCTMRSSVLKEALDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNS

PF03256 // ENSGT00890000139411_0_Domain_1 (310, 427)

ADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKG----AEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCALDIPHCALLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRTNKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEANPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-NHL--HPLDK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLSD---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSSPE
---DQALPVAVPTRASEEQLEKKAVQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LTKDPSCQTQISDSPADASP----PIGLPDA
ED--SEA-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALSAPLHILRAIYELQMKKTDYFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHA-------------------------------------------
-----------------------------------------LQNIAAISLAINYPNKATR
LWNVER

------------MGNAPSNSSEDEAAAAGGEGW-SP-HQDWAADSGTTP------SP---
--GPAAA--VLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGTHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLVRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTRYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKFALRSF------TSERLGVQGLSICGYLRPARAEAEQ-S
ILCAHCRKDT-ENIYGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQSDPPAASEEEKPAAQCPEG----MQA
AKELYTHLCD-------VVDRADGDSMPMEILKQEVRNTLLNGAAIFFPDRQTRRDQLFT
MMKNVTEHEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSDLTNTNTSEVLAVMNTLLSV
AARECELLMLSRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTDTTAKELAVDLIEKYVG
QFLASMRMILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
SQAKLASVLNSPLWKPVFRHQICPELELEASWPTHPHQDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFSQVYSLADGIRIWMVSLIVWLLSSPQLEMKQKSLVSLGNEAEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPTSKSSKENCDNLVPV-DETDHL--QPLDR
RQRTSSVVEEHFQASASSAEAPA-PKTGD---KSPASETQPQ----------LPPSSGPS
AAEVS--TAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLRDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EHVDGEQLDPQARSNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSE
---NQALPKT--------------VQLAEEPADAG--LF--------------VPSSGKK
-AADKEV-RPLDYKQSK---TA-AEGLS-LTKDPSYQTQTSDVPGS-THGPPGPPGPPDA
EH--PEV-SSQTPVEEKAITPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDTAVIKVLSAKHNLFATADN
-GIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQAQLSQYSQHFAFIASHLLQTN
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQSDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTEHGDLELDERGDQEEE-VDRPVSSPGEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPVRSDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCREGMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNATSHSSEDEGAAAGGEGW-GP-NQDWAADSGTTP-----------
SPGLAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGAVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLEHCNNMCSMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNS

PF03256 // ENSGT00890000139411_0_Domain_1 (310, 427)

ADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENASISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKAGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYEASALISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARADAEQ-S
AICVHCRKDSEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNQREECICAQTLLLQLLQSCFSVLQEEVAAASEGEKAPTPSPRG----AAA
AKELYTHLCD-------VVDRVDGDSVTMEILKQEVRNTLLSGAAIFFPDRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPSGLLLLPEKNDLAGMNISEVLAVMSTLLSV
AARECELLMLNGAQGEAGSVLFSLFWSVQGSLLSWCYLQLKGTDCGAKDLAVDLIEKYVR
QFLASTKVILDSLLSQYSGKTIVETLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
AITELLKKLCSDCDG-GLNKLDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNKAV
PQAKLALVLNSPLWKPVFRHQICPELELEASWPTHPHQDSKEVKNIPDDPCCHFLLDFAQ
SQAAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKMALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNETEEKH
GSE-AAETNPESL--AKECIQKSLLLLKFLPMGISSKESCDQLVTTDET-DHL--QLLDK
RQRTSSMVEEHFQASASPTEVA-P-SPGH---QSPGLDVHPK----------LLPSSGPS
AAEGSSAMVEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYLVLKDIMD
FIKDQSLSSESVVKVLALKKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRNAYYQLVLFLVKAIKGFGSIND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIQLPELLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMEECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPSHRYRCL
QCNDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRIHCNVCYDFDLCF
GCYAAKKFSCGHLPTHSIRAHPMVTIRISDRQKLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQVRDSATTLRSRCMQLVGDCLMKAHQGK--GLKALALLGVLPDGEPTPA
---NEDLPVTVPTQTSEEQLQKKAVHDAGALSE-AGP--------------------GKE
-AVHEEV-RPSDHKQRN---KTD-EAMS-LMKDPSCQTQISGSPTDASS----QTGLPGA
ED--SEV-SSRNPTEEKAVTSSPEQVFAECSQKRILGLLAAMLPPLKLGP--IVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLILRLLPAEVDGAVIKILSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSSPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKSRKRK-TVKDYQLVQKGGGQEYG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHSFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTWAEHRDLKLDEQGDSGEEV-DRPVSSPDNLERKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIFELQMKRTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLKVEEQIAKAVDTDMIILPCLSRPAHCEQATAEANPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAIRDYLFRVNEATSVLYARHV
LAALLAEWPGRVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEESGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVPCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDMTQPGIL-LPLHRALTE
-LFFVTENRAQELGMLQDYLLAL-----TTDDHLLRCAAQALQNIAAISVAINYPNKATS
LWNVQC

------------MGNAPSHSSXXXXXXXXXXXX-XX-XXXXXXXXXXXXX----------
XXXXXXX--XXXXXXXXXXXXXXXXXXXRCCPHPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GVNLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLVRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTISDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVR-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-SHL--QPLNK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSSPE
---DQALPVTVPTGASEEQLEKKAVQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LSKDPSCQTQISDSPADASP----PTGLPDA
ED--SEV-SSQKPIEEKAVTPSPEQVFAECSQKRTLGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSRAQLSQYSQHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDYFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGAEGW-GP-HQDWATVSGTTP-----------
SPGLAAP--ALPPAATLLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGGSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGIHSSMILRFLHRNRL
SSAVMPYPTLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPDMDKL-KSVAKCY
AYIETS

PF03256 // ENSGT00890000139411_0_Domain_1 (307, 429)

SNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTRKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLLLSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFYAEEHFKRFAKYDKWKLQELRQFVKSRIGCSPDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCKKDTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFFVLQGDVLAASEKEKAPTQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKEEVRNTLLNGAAIFFPNRQTRRNQLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLANMNISEVLAVMNTLLSV
AARECELLMLSEAPGESGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDIAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAPRQLVIFLLDFCTLDISHCTLLREFS
ALTGLLKKLCGDPEG-GLTKLDVETWQQ-EQPVVLHTWTKESAHSYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGSNMAI
PQAKMALVLNSPLWKPVFRHQICPELELEASWPTHPHQDSKEVKNISDDPCHHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGRIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEGKR
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGISSQESCDKLVTADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTKAAPP-ATGD---WSPGLDTQPR----------LLPSSGLP
AADVSPAAAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKNVMD
FIKDQSLSHRSIVKVLALRKAQAQGILEVLKITQYCAESLGQPHCFQPPFILFLLELLTC
QKDFTNYFGHLEGCGANLHKEIRDIYYQLVLFLVKAVKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIIPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGEDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDCQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILP------E
---DQALPATVPTQASEEQLEKKAVQGAEGSEAD--PSV--------------HC-NGWR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LMKDPSCQTQISDSPADTST----PTGLPDA
ED--SEA-SSQKPIVEKAVTPSPEQVFAKCSQKRILGLLAAMLPPLKSSP--TVPLRDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKATHLLFSLGAVCLD---SQVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTETN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
VDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMSALAEHGDLERDEQGDREEEE-EQPASSPGNPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDKLTT
DERIRSLAQQWQPSKSLRLEEQSAKAVDTDMIILPCLSWPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
PMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSVKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLLEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCSHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENLAQELGVLQDYLLAL-----TTDDHLLRCATQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------QAFAQFDTEGDGMVDVENMLE
MLKSSAAGGSLHG--ELSHVIRQLQACSLVPGFIDIFSESNERLSHHASTILRFLRRHRI
ASTAIPYPVLEYFNNICTMRSAVLKDSLDRMLLKEK-ECPGDLSGNQELDKF-KSVSKCY
THIETSSNSE

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 427)

DIDKMTNGETSSYWQSD--GSARLHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVSVGRTASNLQEVRDVHIPSNVTGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVRKGGVSVCDASAIWCWSL---LTSLVTASTQT------SPPIV---H
AILQNTQKALQHMPPLSLSPGSTDFSRFLSPNVLEEVDSFLLGITSHYVTPEVELTLLAF
SLARGSVSKVLSALCAIADHPETPYQAAPLTASMAAVRQKLLYKY---GASLRLTLQACD
VKGKEDTSGPENLLVEPWTGDEGFLTETGKRRASVILASGTEAALQVTQIRIKVRRGAIG
ARCGLVFAYNDPSSEKFHAEGHFKRFESYDKWKLEDFREFLKNRSGAPSDELGEDDPVGW
FEAEEEWDEVEVKVQPCRVAQFLMVKFLCPRQEKAERLGVQGLCALGYLRPPSPQPGR-S
LACLHCPRPEGATLCGVTLLLRTLAFVQQLAQDL--VQKKESGLRYRPYLDFSGLDLKLF
WNFYRKLLDNPRQECVEGQALLLRLLRSCFSALPSPDGAPESQAAAEAGTPSADPGDRQA
AEELHRHLCQ-------VVDGDS-ELPSLQALKQEVTDTLLNGAAIFFPQRRIRREQLFA
ML-NITEQEHKPSVQLTFRSLCAYFSDQDPGGLLLLADKGTSAEVDIDQVLSVMETLLMV
MSRECEMLALGAAQPDSGPVLSSLFWSVQGSLLSWCYLQMKGSQAAPKKLAADILTKYVR
QFLSSATAVLEPLLAEHGGKSLEEALGSSVFSLVSRQLMTFLQDFCALDVPHRTLLQDVS
TLTPLLKELSLGPGEGAPHQMGLEGLQQ-EQPVVLRVWTVESPHNYDNNCHDFTVFLCPG
ATYFEVEFDDRCETERRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYRFCVTAYGLPDLEVSWGLDLHLLVARLMGRLAAHSMALHHQHHEAGNEADL
LPAKVTAVLSSPLWKPVFRHRMCSEQDAAESGPSQEA------SVSEASDCRQFLLDFSK
SDPGQAFSGPNSELFEGLAQACRKPAPKTDIVAGSTVDQAIQSAFAALVYLSPDLFEKLQ
TYVNSGGQMPLSEEFAQVYSVADGIRIWML------------EMKQKFLMDQGSDGEERP
GGE-VDQVSPETL--AQQCIQKSRLLLSFPSGAEGGASGG-GV--GGAEAGGR--CPREG
PRRTSSLLEADFQPSTDSSSPAPPPSGWP---GFPFPGEPKRTPP---PQAVVPPAVVP-
--PPPSPPPEAPSPPSTPTRKPPFSRGRLRLLSFRSM--EESRPAPSIKEKHPILKHALD
FIKDQSLSHQSVLRVLAMRKAQAQNVLEVLRMTLRCLEALGRPHCFAPPCVAFLLELLAS
HKDFTTHLGHLEGCGAKLHREIRASYHQLLLFLVKALKGFDNLRD---KSLLPALSCVQT
CLL-HLLDMGWEPSDLSFFVDIQLPRLLLTVSQENIGSHLTASRQWSEEEEMSDYKQNSE
WMDECQEGVFEIWFDKISQADPEKQRKMHMFIARYCDLLRVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1933)

FSCNGCDEISPWHRYRCL
SCNDMDLCKACF

ENSGT00890000139411_0_Linker_2_3 (1933, 1951)

LGKAGVRPEGHEAHHEMV

PF00569 // ENSGT00890000139411_0_Domain_3 (1951, 1987)

HMA-HCGQCRGVIVGQRAHCDVCQDLDLCF
GCYSTKKPPDSHLPSHSVTLHPTLTVRASERHRPIQPYLHNYSWLLFSALALYSADLAGG
GGPAEGEPPDPQAVSSARALRQEFLELLGDCLVKAQPGK--GLKGPTLLSMLPEGENFDE
NA---APSVGASADTETQHFA------NEDVVGSL--LA--------------TPGNGKD
-TLDER--DPDSRKGVS---GA-SNGLPPTKKATSCSESLSPGKGT-----SS--FLQTV
QV--VLVSVSVPGSEWAKAASVQEALFAECSQKRILGLLAAMLPRLKPGPG-TLPLPGLD
VVLPLLFQEVISNAGRLNEAYHLALGLLGQVVRRLPPAEVDATLGKVFSAKHGPAAAGEG
PSAAPHGWKTTHLLFSLGAACLD---SRLGLDWACILAEALGALGASPQWHGVVSSFTEH
CVRQLPFQ--LKHTNLFALLVLVGFPERRQVLCTGSRAAYVDVANEAHDVVVLKHFAEKD
RAVIVDVKTRKRK-AVKDIQLVQPCGRDDDNS---GEPEGHLRPYVRHFVSIACHLLQSG
VDSGSAEAVEATWVLSLVLKGLYQTLKTQAFEE-IRTAFLQTGLLKLLVKKCSKGTGFSK
-WLLRDLEILSMMLYSCKKQAGSLAEEHKEEEPDPERD-----PDQAAAATGATQGRLDP
LEGLDETT---KICFLMTH-DALDAPLHILRAMYELQMKRRDSFFLEVQKRRFDGDVVTT
DERIRTLAQKWQPGKRLRPEEHGNKALDTDMVIVPGLSKPAPCASASEESSPVTQKLISS
TEADLRLSYAKQRRAKSAVLLRKELEPSPSPSPRRGGPRGARGFLYRLHKATAVLYARHS
LALLLAQWPPQDPLGPEMLELSGPAHMAYILDMLLQLEEKTLCEKILLKVLRSCDEGMLS
TMALTACQFMEEPGVAVQARESQHPYNNNTNFEDKVHIPGAIYLSVKFDPQCNTEEGCDE
LVVSSSGDFAHDRHTFSGPPHKWADFELPGD-----------------TLHYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERAVPHIPLGEVWAWQVGVAC-RQTGHQR
LKALHLLLRIVQRCGRGD-CD-LALLRPLWRLFGCLESGLRHEASKPGLL-LPLHRALTE
-LFFVAESKARDLGSLQDYLLAL-----NTDDHLHHCTAQALQNIAAISLAINYPNKSTG
PWNV--

------------MGNAPSHSSEDEAAAAGGEAW-GP-HQDWAKDSGTTP-----------
GPGPAAP--ALPPAAALLEPARLREAAAALRPAPP-------YESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFGELLEARGAGFSG--E

PF00036 // ENSGT00890000139411_0_Domain_0 (157, 185)

RFEEAFAQFDAEGDGTVDAENMLE
ALKN

ENSGT00890000139411_0_Linker_0_1 (185, 278)

SS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDVHSSMILRFLHRNRL
SSTVIPYPMLDHCNNMSTMRASVLKDSLDQLVQKEK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 446)

ESPGDLTRSPEMDKL-KSVAKCY
TYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASA

ENSGT00890000139411_0_Linker_1_2 (446, 1899)

IWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCSSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLILQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCPSDNLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IVRTHCRKGVEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYRSFLDFAGLDLQIF
WDFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDVSATSEDAKAPSMSRRR----VEA
AKELYTHLCD-------VVDRVDGDSAPMEILKQEVRNTLLNGAAVFFPDRQTRRDHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKGDLADTDISEVLAVMSTLLSV
AARECELLMVDGAQGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAADLIEKYVG
QFLARMRVILESLLSQYSGKTVVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTELLKELCSDPDG-GLNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLNSPLWKPVFRHQICPELGLEASWPTHPPQDNKEVKNIPDDPCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYXXXXXXXXXXXXXXXXXXXXXXXXXXXL------------EMKQKSLMSLGNEAEEQR
GPE-AAEVNPESLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX
XXX---XXXXXXXXXXXXXXXXXX-XXXX---XXXXXXXXXX----------XXXXXXXX
XXXXXXXXAEEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPLPTVKEKYPVLKDAMD
FIKDQSLSHESVVKVLSLRKAQARSILEVLRIIQCCTESLGQPHCFHPPFILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFSNVND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLTFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1993)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-EDVDGEKLDPQARSSAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTSE
---KQAPPVAVPTQTSEEQPEKKAIQAAVEP-ADAGPFV--------------HR-SGKR
-DAPKEV-RPLDCKQRS---KAG-GAAS-LLKGPSCQTQISDSPADACA----PTELPDA
EN--AEA-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLSPVEVDAAVTKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCAGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVNVKTRKRK-TVKDYQLVQKGGGPECS-----NSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAEHGELELDERGDQEEEV-ERSVSSPGEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPARCDQATTESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRESMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGPQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVSVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LMLLKPLWQLFTQMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMD

PF03256 // ENSGT00890000139411_0_Domain_1 (291, 429)

KL-KSVTKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLYNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSLAKVLNSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKQFEKYDSWKLQELRQFVKSRIGCSSDDLGEHDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEK-N
ILCAHCRKEA-ESVCGGTLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQRDALAAP-EEKPSTQCLGE----VEA
AKALYIHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVSEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLSV
AARECELLMLSGAQGQIGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKELAVDLIEKYVV
QFLASTRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDIPHCTLLRDFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLSSQCMALKSVH-QVGSNMAI
PQAKMASVLNSPLWKPVFRHQICPELELEASWHTHPHQDGKEVKNIPDDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPELYEKLQ
KYVNSGGKTPLSEDFAQVYSLADGIRIWML------------EMKQKSLMNVGSEAEEKH
GLE-AAETNPESL--AKECIQKSLLLLKFLPMGKSSKEHCDKLVTA-NETDHL--QPLDR
HQRTSSVMAEHFQASVSPTEAS-PSTVGD---RSPGLDIHPK----------LPPSSGPP
AAEVS--TAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKTQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLAC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAVKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPGDLAFFVDIQLPDLLMKMSQENISVHDSMISQWSEEDELADAKQNSE
WMDECQDGMFEAWCEKIAQEDPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EDMDGEKLDPQAHSHATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDTTPE
---MQALPITVSTCTSE------------EPAEPG--PF--------------VYCN--R
-AVDKEE-ISLGYKQRN---KT-DEGLL-IMKDPSCQTQIAGVPAD-ANLSS---GLPAA
EN--SEA-SSQKPVEEKTAPPNPEQVFAECSQKRILGLLAAMLPPVKLGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFASGDN
-AVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGTQESI-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-TQTTFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEEVEQQPVSSPGEPEQKKLDP
LEGLDEPT---RICFLIAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPSRNLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPEHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQKDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTHMEYGLFEDMTQPGIL-LPLHRALTE
-LFFVTENRAQELGLMQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATH
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTPG----------
-PGVAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRL
SSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKG----VEA
AKELYTHLCD-------VVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVR-QLGSNMVV
PQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEVNPESL--AKECIEKSLLLLKFLPTGISSKESCEKLETADET-SHL--QPLNK
RQRTSSVVEEHFQASVSPTEAAPP-ATGD---QSPGLGTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSSLE
---DQALPVTVPTGASEEQLEKKAVQGAELSEAG----------------------NGKR
-AVHEEI-RPVDFKQRN---KAD-KGVS-LSKDPSCQTQISDSPADASP----PTGLPDA
ED--SEV-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSRAQLSQYSQHFAFIASHLLQSS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-IRATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDYFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRL
SSTVIPYPVLDHCNNMCTMRASVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADIDKMTNGETSSYWQSD--GSARSHWIRXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVQINIKRCLSDGCDT
RIHGLRAVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXKPLQLTLQACD
VKGKEEKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEYRQFVKSXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXYLMVKFLCTRQESAERLGVQGLSISGYLRPTRAEAEQ-S
IVCAHCRKAGEESICGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQN-REECICAXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXX
XXXXXXXXXXXXXXXXXXVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVG
QFLASLRVILESLLSQYSGKTIVEKLCNLVFSMAARQLVIFLVDFCTLDISHCTLLREFS
TLTDLLKELCGDPDG-GVNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCLALKSMH-QLGSNLAV
PQAKMALVLNSPLWKPVFRHQMCPELGLEASWPTHPHQDDKEVKNIPDDPCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALGEEFAQVYSLADGIRIWML------------EMKQKSLVSLGNEAEEQR
GSE-VAEANPESL--AKECIQKSILLLKFLPMGVSSKESCDQSVTA-GEVDRP--QPRDR
RQRTSSAAEEHFPALACPSGAAAP-AAGD---RSPGLDGQPT----------LLPSGGPP
AAEASSAAAEEPSSPSTPSRRPPFTRGRLRLLSFRSM--EEARPVPTVKERYPVLKDVLD
FIKDQSLSHDSVVKVLSLRKAQARSILEVLRIIQGCTESLGQPHCFHPPYILFLLELLTC
QKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYASKRYSYGHLPTHSVTAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAGA
-EDVDGEKLDPQARGNANTLRSQCLQLVGDCLMKAHQGK--GLKALALLGILPDGDSTAE
---DQAPPGTVPSRAPEERLEKKASEAAA------------------------EAADGKR
-DVPKEV-RPLDCKLRS---KADKGGA--LMKDPSCQTQISDSPADAST----STGLPDA
EN--SEA-SSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TVPLIDLE
HVLPLMFQVIISNAGHLNETYHLTLGLLGQLIIRLLPAEVDVAVTKVLSAKHNLFAAGDS
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWREVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTDKN
RAVIVDVKTRKRK-TVKDYHLVQKGGGQEYS-----DSHAQLSQYSQHFAFIASLLLQTS
MYIHCPEEVQATCVLSLVL-NLYXXXXAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISTLAEHGELELDERGDQEEEV-ERSASSPGEPEQKKLDP
LESLDEPT---RICFLMAH-DALNDPMHIFRAIYEVQMKRTDSFFLEVQK-XXXXXELAA
DERIRTLAQRWQPSRSMRMDEQNAKAVDTDMIILPCLSRPARCEQATAEANPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
------XXXX-XXXXXX-X-XXXXXX-------XXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXDLCD-LTLLKPLWQLFTQMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQ--------------------
------

------------MGNVVSGGSGDEEETGMEQEEAATTGTDATAGSG----AQANPLQPGV
-PGPAPPLLLPPSPGVLLEQARLREAAARLREIGA-------PESVVSRNQSALLRWLEE
RL------SRGEELLSKDQFIEMLESRASGR----EECEEAFSQFDAEGDEVVDLESMLE
AIKSSS-GASLKG--ELSHVIRQLQACSLTPGFIDIFSKSKEPLSLHSAKILGFLHRNRV
PSTAIPYPMLECCNNICTMRASVIKDYLERLLKKEK-

PF03256 // ENSGT00890000139411_0_Domain_1 (278, 451)

ECPAVVSSDEESLQF-KTVTKCY
SQIETSSCASDIYKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRQLSIAVSAADQS
YMPQHVAVAVGRNPSNLQEVREVHIPSHITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLRAVGYQKIKR-AVSISDASAIWYLS

ENSGT00890000139411_0_Linker_1_2 (451, 1899)

L---LTSLVTTSMET------NPSLA---Q
AVQQHTQKALQHMPPLSLTLGATEFPNFLSPNVLEEVNSFLLRIASCCPTPEVNLDLLAF
ALARGNVAKVITALCSIMEHVDLQYKACALISSMESVRMNLLYKY---AKPLQFTLIACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASVILSSDTESAFQVTQMRIRVRRGDIG
AKCGLIFAYNS--SEKFHAEEHFRRFEKYDAWKLPEFKQFVKERTKKPDIELGENDPVAW
FELEEEWDEVDIQMQQCKTAKYWMVKFLCAREETAERLGVQGLSSYGYLRKLDEESKV-N
IMCLQHKEVAKESVCGMTLVLKTLLFIQQLAHDMYFLQEKENRSKYKPLLDFSGLDLQLL
WQFYKKLEDNPREEYVFIKTVVLQLLQSCSSVITTRKLAQDE------------SNDFHC
SQELYKHLCN-------ALDNMDSTSLPSSILKQEITNTLLNGAAIFFPDRLSRRERLFS
LMRSITEEEQPLSVRITFQSLCSYFSEQDPGGPLLLPEAELPADFDISQALSVMDKLLLM
VIRESKLLVVDATQGECSSVLHSLFWAVQGSLFSWCYSQLKGNDPVWQVKARELLVQYVE
LFLIKMKNILECLLVKCSGKEITEKLSISVFGMATRQLMTFMLEFCSLDIPHCSLLQSFS
TLTELLKKLCGNLGK-STYKEEMESWNLVQQPVVLQTWNMESPHNYENNCRDITVFLCPG
ATYFEVEFDDKCETERRYDYLEFTDARGGKVRYDHKVGSDKWPKKVTFKAGPQLQFLFFS
DSSNNEWGYKFTVTAYGLPDIPLSWSTDLQLLVARLMGRLASRCLSLKNMC-ELGSVAEL
PFAKVTSVVSSPLWKSVFRHQMGTDNELKAEL-TSLHQGNKETKNSHADDCRNFLLDFAN
SDPTQDFCGPNSELFKGLTQAILKQPPKSEIVAGSVIDQAVNSTFAAMVYLTPQLHRKLQ
RYVLNGGSIPLCEEFAQVYALAEGIRMWML------------EMKQKSLQTMGSDKLSQ-
---DITETNPQML--AKQCIEKSLLLLKFLPVVSTPLLDSCHS----VEDAHL--LHC-E
ERRKSSVVETDFQAASASPETTYPPFLGKL--QIPCSEA-LKTQE---SH-HETPSGVPI
--KNPEKVEQPISPPPTPSRKAPFSRARLRLLSFRSV--EEARLTPTVKEKYPLLRSILD
FIKDPTISHESILQVLSLRKAQAESVVKVLKVVQDCVQTLGQPHFFHPPCVLFILELLSC
QTDFTNYFGHLEGCGGDLHRAVKESYYQLVLLLVNAVKSFSSLNE---GSLLPALSSMQT
VLL-HMLDMSWEPEDLSFFLSIDLPSLLFSMCQENISSHDSIVSLWDEEDERADYRQNLL
WLEECKDGMFEIWYETIAQADPDVKRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1945)

LNVEISCDGCDKIAPWNRYRCL
QCNDMDLCKTCFLG--GVKPEGHEYTHNMLQLCFGLGKAPKN-YIRRMRCSVCREYRFVR
GWTL--EHFFSHLPTHSITIYPMVTNRISDNQRLIQPYIHNYSWLLFTALALYCSDLASE
-GEIEGEKLDLSVVSSAQLLQANCTDLVANCLMKTQKGK--GLRMSSLLSVWSNNKLFSE
HKASSSSLL---------ELKKSDLPNNNTDQSNLRKKQ--------------LCCDQQA
-PVKSS--------------------VL-LVCNQFCRQQSNSGCLKLQ-ILP---LLIKL
ED---DISSHCVLVIKNAVIPSPDEVFAECSQERILGLVGAMLPPLKSSS--LVCVTNLQ
HVLPLMFQVVISNAGHLNESYHLTLGLLGQLILRLPPADVDAAVNKVLSSKCNIQS----
--------------------------SKVGLDWACTMVDILRELNGSPQWHKVIALFADH
CIKELPQQ--LKNTNIFTLLVLVGFP---EVLCMGTQSVYVDNAKEPHDVVILKHFTEKN
RAVVVDVKTRKRK-TVKDNQLIHQSDSEN------QGLQEQLKKYLQHFACITSNLMKSN
LNNGSAEAVEATWVLSLSLKGLYKTIKNHCFEE-LQSAFINSGLLKLLVKKCSKGTGFSK
TWLLCDLEVLSIMLYSSKKEISAVSEKDDSGSEKQDQDKDL-------YTSHDSTVKSDP
LEGLDEAT---KICFQVIH-DALNAPLHILRAVYEMEMKSTESLLQEVHK-KFDEKTGVI
DEKVKKMAQKWQPCKPGKSEEQSLKAVDTDMIIQPCTLKPVLCEKATEESNPVSQKLIVT
SESDLQRSFAKQRRAKSSVLLRKELDSRS-------K-IAVRDYLFHVNEATAVLYARHV
LASLLAEWPYGVPLNDDILELSGPAHITYILNMLMHLEEKQLWEKILQKVLGGCSESMLG
TVALTACQFMEEPGTAIQVRESKHPYNNNTIFEDKVHIPGAIYLSVKFDPLCNTEEGCDE
LVISTSSDFKQDLHRFSGPPKKWIDFELPGD-----------------TLYYRFTSDMSY
TVWGYKFTVAAGHRGRFQTAGFEILKQMLSDQRVEPHLPLSDIWDWQVGVAC-RQTGHQR
LKAIHLLLKILKLGPGR-DCD-LKLLKPLWPLFTGMEKMVNQDSGSNGVL-LRLHRALTE
-LFFIAENLANETGCLQEYLMTL-----ITEEQISHYTAQALNNIAAISFAINYPNKSTS
VWTA--

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAADSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHCALMRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSTVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-

PF03256 // ENSGT00890000139411_0_Domain_1 (294, 429)

KSVAKCY
AYIETSSNPADIEKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVASTDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVMHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCAITDHLDTQYDASSLISSMASVRQNLLLKY---GKSLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGNESAFQVTQIRIMVRRGGIG
AQCGLVFTYNSS-SDKFHAEEHFKRFEKYDTWRLQELRQFVKSRIGCSSDDLGEDDPVGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
ITCAHCRKDTEESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYNKLKQNPREECICAQTLLLQLLQSCFSVLQGDGAA-SAEEKAPTKSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERNDLTDMNISEVLAVMNTLFSV
AARECELLMFSGTQGEVSSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLLEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMASRQLVIFLLDFCILDISHCTLLREFS
ALTELLKKLCSDPEG-GPNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRFASQCMALKSTC-QLGSNMAI
PQAKMALVLNSPLWKPVFRHQICPELELEANWPTHLHQDNKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSEFFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIVLSEEFTQVYSLADGIRIWML------------EMKQKSLMNLGNETEEKH
GSE-AAEANPESL--AKECIQKSLLLLKFLPMGLSSKESCDKLVAADET-DPL--QQLDK
RQRTSSVVEEHFQASTSPTNTALP-AAGD---QSPGLDVQPK----------LLPSSGPP
AAEVSPVTAEEPLSPTTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFSSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGERLDSQARSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---SQVLPVTVSTRTSEEQLEKKTAQGAEELLE-ADPFM--------------HC-NGKN
-AAHEEV-RSLDYKNRN---KAE-EGIS-LSKDSSFQIQILDSPSDTST----PTGLPDA
ED--SEA-SSQKPLKEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-STVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIIDVKTRKRK-TVKDYQLVQKGGGQECG-----DSHAQLSQYSQHFAFIASHLLQTS
MDSHFPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKNQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSVKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATC
LWNVDC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAESVTNP-----------
GPGPAGP--ALP-AAALLEPARLREAAAALRPSPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGVGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPADI

PF03256 // ENSGT00890000139411_0_Domain_1 (313, 427)

EKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSTGDLQEVRDVHIPSNITGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCSSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLISSMTSVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSSGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQRCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VVCAHCRKDAEESVCGATLLLKTLQFIQQLAHDL--VQQKESSLKYKCFLDFTGLDLKIF
WNFYSKLKQNLREECICAQTLLLQLLQSCFSVLQGDAPA-PEEEKAQNQSPEG----VEA
AKKLYTHLCD-------VVDRVDRDSVTMEILKQEVRNTLLSGAAIFFPDRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTHFSDKDPGGLLLLPEKSDLADMNISEVLAVMNTLLSV
AARECELLMLRGAQGEVGPVLFSLFWSVQGSLLSWCYLQLKTTDTGAKELAVDLIEKYVE
QFLASTRVLLESLLSQYSGKIIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-RLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHDVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTITAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSAH-QLGNNMAV
PQGKMALVLNSPLWKPVFRHQMCPELELEASWPTHPHQDSKEVKNIPDDPCCNFLLDFAQ
SDPAQSFCGPNSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKAALSEEFAQVYSLADGIRIWML------------EMKQKSLMGLGNEIEEKH
DAE-ANDANPERL--AKECIQKSLLLLKFLPMGVSSKESCDKLVTADET-DHP--QPLDK
RQRTSSVMEEHFQASSSPTEAAPP-AVGD---GSPGVDIHTK----------LLPSSGPP
IADVSSATSEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FVKDQSISCESVIKVLSLRKAQARSILEVLKIIQYCAESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGAELHKEIRDTYYQLVLFLVKAIKGFSNIND---RSLLPALSCVQT
TLL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASS
-EDVDGEKLDPQARSNANTLRSQCVQLVGACLMKAHQGK--DLKALALLGILPDGGSSPE
---NQALTVTPPSQIPEEQLKRKAVEVAEE-LSGADPLV--------------HC-NGKV
-HIHKEI-RYLDCKQRN---KTD-ESIS-LMKDPSCQTQISDSSAVAST----CTELPDA
EY--SEA-LSQKPVEEKTVTPSPEQVFAECSQKRILGLLAAMLPPLKLGP--TVSLVDLE
HVLPLMFQVVISNAGHLNETYHPTLGLLGQLIIRLSPAEVDSAVVKVLSAKHNLFAAGDS
-SITPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDIKTRKRK-TVKDYQLVQKG-GQECG-----DSQTQLSQYSQHFAFITSHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-IHATFLQTDLLKLLVKKCSKGTGFNK
TWLLRDLEILSIMLYSSKKEISTLTERGELEVDDRGDQEEEV-ERAVSSPSEPEQKKLDP
LEGLEEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPGKSLRLEEQSAKALDMDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPGRVPVSEDILELSGPAHMTYILDMFMQLEEKQQWEKILQKVLRGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCSTHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATH
LWNVEC

------------MGNAPSNSSEDEAAAAGAEGW-SP-HQDWAADSGTTP------GP---
--GPAAA--ALPPAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFRELLEARGVGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGTHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKL

PF03256 // ENSGT00890000139411_0_Domain_1 (293, 429)

-KSVTKCY
AYIETSSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSADFSTFLSPNVLEEVDSFLLRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTRYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSAGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SEKFHAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKFALHSF------TSERLGVQGLSISGYLRPARAEAEQ-S
ILYAHCRKDT-ENICGATLLLRTLQFIQQLAQDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQNDPPAASEEEKPAVQCPEG----MQA
AKELYTHLCD-------VVDRADGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNQLFT
MMKNVTEHEHKQSLQLTFRSLCTYFSDRDPGGLLLLPEKSDLASTNTSEVLAVMNTLLSV
AARECELLMLSRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTDTAAKELATDLIEKYVG
QFLASTRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCNLDVSHCTLLREFS
TLTELLKKLCSDPEG-GLSKMDVETWQQ-EQPVVLHTWTKESTHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDSRGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-HLGSNMAV
SQAKLASVLNSPLWKPVFRHQISPELELEANWPTHQHQDGKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKITLSEEFSQVYSLADGIRIWMVSLIVWLLSSPQLEMKQKSLVSLGNEAEEKR
GLE-AAEVNPESL--AKECIQKSLLLLKFLPTSKSLKENCDKLVPV-DETDHL--QPLDR
RQRTSSVVEEHFQASASPTEAAAATTGGD---KSPGLEIQPK----------LPPSSGPS
ATQVS--TAEEPSSPSTPTRRPAFTRGRLRLLSFRSM--EETRPVPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMNMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTGT
-EHVDGEQLDPRARSNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTSK
---NQALPGTMSIQTSEDQLEETKVQLAEEPVDAS--LL--------------VPCSGKR
-AADKEV-RPLDYKQRK---MA-GESPT-LMKDPLYQTQTSDAPAN-AHMPP---GPPDA
EH--PEV-SSQT-AEEKAITPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIVRLLPAEVDTAVIKVLSAKHNLFAAADN
-GVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNNAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----TSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLTEHGDLELDERGDQEEE-MDRPVSSPGEPEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSRPVRTDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCREGMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHIPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAADSGTTP-----------
GQGPAAP--ALPPAAALLEPARLREAAAALRPTPP-------CESLVSRHHGALLRWLEE
RL------GRGEESVTLEQFGELLEARGAGFSG--ERFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDVHAAMILRFLHRNRL
SSTVIPYPMLDHCNNMSTMRASVLRESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIETSSNPAD

PF03256 // ENSGT00890000139411_0_Domain_1 (312, 427)

IDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRTASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLRNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCRSTPEVELTLLAF
ALARGSVAKVLSSLCTVTDHLDTHYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEEKSGPENLLAEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFHAEEHFKRFEKYDKWKLQEFRQFVKSRIGCSSDILGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
IICAHCRKSTEESVCGATLLLKTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDAPAAAEDAKAPSPRPRP----VEA
AKELYAHLCS-------VVDRLDGDSVPMEILKQEVRNTLLNGAAIFFPDRLTRRNHLFT
MMNVT-EQEHKQSMQLTFRSLCTYFSDKDPGGLLLLPEKGDLADMDISEVLAVMNTLLSV
AARECELLMVDGAQREVGSVLSSLFWSVQGSLLSWCYLQLKSTDSGAKDLAADLTDRYVG
QFLAHVRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
ALTELLKELCSDPEG-GVNKLDVETWQQ-ERPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQIHPELGLEASWPTHPPQDNKEVKNIPDDHCHQFLLDFAQ
SDPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKTALSEEFAQVYSLADGIRIWML------------EMKQKSLMNLGSEAEEQR
DPE-AAEANPESL--AKECYQKSLLLLKFLPTGGGSKESCDRSVAVDDTDHLQ---PLDK
RQRTSSVVEEHFQASASPTEAAPP-TAGD---RSPGPDMQPT----------LPPSSGAP
ALEVSSVPAEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPAPTVKEKYPVLKDLMD
FIKDQSLSHESVVKVLSLRKAQAWSILEVLRIIQCCTESLGQPHCFHPPYILFLLELLTC
QKEFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVKAVKGFNSKND---RSLLPALSCIQT
ALL-HLLDMGWEPSDLTFFVDIQLPDLLMKMSQENISAHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1943)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEG

ENSGT00890000139411_0_Linker_2_3 (1943, 1952)

HGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEFTCDHCQGLIIGRRMHCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDVDGEKLDPQVRSSAATLRSRCLQLVGDCLMKAHQGK--GLKALALLGVLPDGGSPLE
---NQALPVTAPTQTSEEQPEKKAVQAAAEP-APTGP--------------------GKR
-DGPKEV-RPLDCKQRS---KAS-EGVS-LRKDPSCPPQISDSPADACT----PTGLPDA
EN--SEA-SSQKPIEEKAVIPSPEQVFAECSQKRILGLLAAMLPPLNSDP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVTKVLSAKHNLFAAGDS
-SVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVVATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQEGS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKVHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGELELDERGDQEEEV-ERSVSSPGDQEQKKLDP
LESLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELTT
DERIRTLAQRWQPSRSLRLDEQSAKAVDTDMIILPCLSRPVRCEQATVESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVREYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEDRHQWEKILQKVLQGCRESMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPYLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTQMEYSLFEDVTQAGIL-LPLHRALTE
-LFFVTENRAQELGLLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQGCSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPQMD

PF03256 // ENSGT00890000139411_0_Domain_1 (291, 429)

KL-KSVAKCY
AYIETSSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNVAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKDCIEKSLLLLKFLPTGIRSKESCDKLETADET-NHL--QPLEK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDAYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSIPE
---DQALPATAPTQASEEQLEKKTVQGAELSEAG----------------------NGKR
-AVHEEV-RPADFKQRS---KAD-KGVS-LTKDPSCQTQISDSPADAST----PTGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPISSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGTAASHSSEEEEEGAEEG-------MEGAAGA---------------
----PQAAPLLPPAEVLLEQARLREATARLREAAL-------PEPLVSRHHSALVRWLEE
RL------SRGDEAVSLEQFCEVLESVSRLAAGSRGESEEAFAQFDAEGDGTVDVENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRI
SSTAIPYPVLEYFNNICTMRSSVLKDSLDRLLLKER-EYPSDLNGNQESDKL-KSVMKCY
THIETSSNSA

PF03256 // ENSGT00890000139411_0_Domain_1 (311, 427)

DIDKMTNGETSSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVAVGRNASNLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLR

ENSGT00890000139411_0_Linker_1_2 (427, 1903)

AVGYQRVKKVGVSVCDASAIWYWSL---LTSLVTASMET------NPAFV---H
TILRNTQKALQHMPPLSLTPGSTEFSSFLSPNVLEEVDSFLIRITSCCTTPEVELTLLAF
ALARGSVAKVLSSLCAITDHLDTPYKASSLISSMAAVRQNLLYKY---GKPLRLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASIILSTGTESSFQVTQIRLKVRRGAIG
AQCGLVFAYNSA-SEKFHAEEHFKRFESYDKWKLREFKQFLKTRSSCSCDDLGDDDPIGW
FEVEEEWDEVDVRMQQCRVSQYLMIKFLCTRQDSAERLGVQGLSVLGYLRPLRDEPCS-T
MSCLQCRKTEEDTVCGTTLLLKTLHFIQQLAQDL--VQQKESGLKYKSFLDFTGLDLQLF
WNFYNKLHQNPREECIFAQTLLLQLLQSCFSVLTGDNKTAKPQETPQ----SKTAGHIEA
AEELYRHLCE-----GAVVDMGDSNFMPMKMLKEEVKNTLLSGAAVFFPDRQTRRHQLFT
MMKNITEQEHKQSVHLAFRSLCTHFSDQDPGGLLLLPEKGVSANFDISEILSVMDTLLLV
AARECEMMMLDVAQQESGTVLSSLFWSVQGSLLSWCYLQLKGTDNSAKDLAVEILKNYVG
QFLSNIRTILQSLLSQYSGKTIVEKISSSVFAMATRQLVIFLLDFCTLDIPYCTLLQGFS
TLIEPLKSLCSEPHK-----TDMESWQQ-EQPVVLRTWTMESPHNYENNCHEVSVFLCHG
ATYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFSVTAYGLPDVAVSWGLDLQLLVSRLMGRLASRSMALKSLR-ELGSEADL
PPLKVTSVLNSPLWKPVFRHQLCPEALPGARQTSAKHQDKNEARSSPHDVCRNFLTDFAK
SDPAQDFSGQKSELFKGLIQACKKQTPKTDIVAGPTVDQAVNSTFAALVYLTPDLFEKLQ
KYVNSGGKVPLSDEFAQVYSLADSIRIWML------------EMKQKSLMGRGNDAEEKQ
NTE-ASEMNPETL--AKLCVQKSLLLLNFLPIRAKTKDSASDSLEAQDMDD-PQQYVSDQ
CQRQGSAVDMDFQAAPSVSSSAGIHPVSKERGQASQSDPKVKQIPDLHQ-----------
----AEEQEDVSSPPSTPTRKSQLSRGRLRLLSFRSM--EEPKPVPTVKEKYPILKNILD
FIKDQSLSHESVLKVLALRKSQGQSIMEVLKTIRQCLDSLGQPHCFHPPCVLFLLELLAC
QKDFTNYFGNLEGCGAELHKEIRESYYQLVLFLVNSVKGFSTIND---RSLLPALSCVQT
ALL-HLLDMSWEPSDLSFFVEIQLPHLLMTTSQENISIHDSVICQWSEEDEIADYKQNCE
WMDECQDVMFETWYEKIAQADPEKQRKMHMFVARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1944)

ISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFLG--GVKPEGH

ENSGT00890000139411_0_Linker_2_3 (1944, 1952)

EDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1992)

MEYACDHCQGVIIGRRMNCNVCDDFDLCY
GCYHAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLANG
-EEVEGEKLDPQVVSHARVLQHQCIQLIGDCLMKAQHGK--GLKNLALLCMLPEDESISE
NC---SVSGSPPTDSAPKS-HPGD-----R--A---------------------------
------------------------------------------------------------
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------

------------MGNATSHSSEDEAAAAGVEGW-GPPSQDWASEKSSTP------GP-GL
A---AAP--ALPSAAALLEPARLREAALTLRPAPS-------CHSLVSRHHGSLLRCLKK
RI------DRL-KSVTLEHFRELLVARAAGCSD--K--FKAFAQFDAEGDGTVDAENMLE
TLKNSS-GANLQG--ELSHIIRQLQACSLVPGFTDIFSESKESLDLHASMILRFLHRNRI
SSTVIPYPLLEHCNNVCAMRSSVLRESLEQLVQKEK-ESPGDLTRSPEMDKL-KSVTKCY
AYIETSSNPADIDKMINGETSSYWQSD--GSARSHWIRXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVQINIKRCLSDGCDT
RIHGLRAVGFQKVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLQNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLLRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTESGKTRASTIFSTGTDSAIQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFRRFEKYDKWKLQELRQFVKSRIGCSSADLGEDDPIGW
FELEEEWDEVDVKLQQCRVAKYLMVKFLCTRQETAERLGVQGLTISGYLRPARAEAEQ-S
IPCAHCRKDT-DSVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKKNPREDCICAQTLLLQLLQSCFPVLQRDALAAAEEGKPPTRNPEA----VAA
AKELYMHLCD-------VVDKAAGDSVPMEILKQEVRNTLLNGAAVFFPDRQTRRNHLFT
MM-NVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKSNLADTNVVEVLAVMNTLLSV
AARECELVMLHGVQGESGSVLFSLFWSVQGSLLSWCYLQLKSTDSAAKHLAADLIEKYVG
QFLASMRMILGSLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDLCPLDIPHCTLLREVS
TLTELLKKLCADPAG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMALVLNSPLWKPVFRHQTCPELELEASWPTHPHHDRKEVKSIPDDPCCRFLLDFAQ
SEPAQNFCGPYSELFKGFTQACRKQALKTDIVAGSTIDQAVNATFAALVYRTPELYEKLQ
KYVNSGGKAALSEEFAQVYSLADGIRIWML------------EMKQKSLMSLDSEAEEKR
GAD-VAEVNPENL--AKECIQKSLLLLKFLPPGVSSKGSNDKLVAA-DEPDHL--QPLDK
RSRTSSVVEEHFQASMSPTETAAP-TTGD---QSPGLDVQSR----------LAPGSGPT
TADASSATVEEPSSPSTPTRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPVLKDVMD
FIKDQSLSQESVVQVLSLKKAQAQSILEVLQVIQYCMESLGQPHCFHPPCILFLLELLTC
QKDFTN--------------------------------------D---RSLLPAFSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKTSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDL

PF00569 // ENSGT00890000139411_0_Domain_2 (1899, 1949)

LNVDISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFLG--GVKPEGHGDDHE

ENSGT00890000139411_0_Linker_2_3 (1949, 1950)

M

PF00569 // ENSGT00890000139411_0_Domain_3 (1950, 1994)

VNMEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYA-KKYFYGHLPTHSITAYPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASA
-EDMDGEKLDPQARSNATILRSQCMKLVGDCLMKAHQGK--GLKALALLGVLPDGHSAPE
---QEALVVPGSCCTSEETLQKKGTQTAEEPAD-----------------------SGGK
-AVHKEV-SPLNGKQRS---KTD-EDVS-LIKEPSSDTPMSDPPAD-AST---PTGLSDT
EN--SEV-LSQKPLEEKAVTPHPEQVFAECSQKRILGLLAAMLPPLKSXX--XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXX---XRVGLDWACSMAEILRSLNNAPLWQDVLAAFTDH
CVQQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYVDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGADCN-----DSQAQLSQYSKHFALIASHLLQAS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-IHATFLQTDLLRLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGEPELEERGEQEEEV-ERTVSSPGEPE-RKLDP
LNGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKRTDSFFLEVQK-RFDGDELAT
DEKIRSLAQKWQPGRSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESSPVTQKLISS
TESELQQCYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATSVLYARHV
LASLLAEWPAHVPVSEDILELSGPAHMTYILDMFMQLEEKQQWEKILQKVLQGCRESMLG
TMALAACQFMEEPGMEVQVRESKHPYSNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCSHSDLCD-LTLLRPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTDEHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSNSSEDEAAAAGAEGW-GP-HQDWAADSGTNP------GP---
--GPAAA--TLPSAAALLEPARLREAAAALRPAPP-------CESLVSRHHGALLRWLEE
RL------GRGEEAVTLEQFRELLEARGAGCSG--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSMVIPYPMLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLARSPEMDKF-KSITKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNPADIYRMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSIAKVMSSLCTITDHLDTQYDALSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFENYDKWKLHNLRQFIKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAETEL-S
IVCAHCRKDT-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WIFYSKLKQNPREECICAQTLLLQLLQSCFSVLQGDTPATS-EEKPAAQRPEG----VQA
AKELYTHLCD-------VIDRADGDSIPMEILKQEVRNTLLNGAAIFFPDRQTRRSHLFT
MMKNVTEHEHKQSLQLTFHSLCTYFSDKDPGGLLLLPEKSDLANTNISEVLVVMNTLLSV
AARECELLMLSRAHGEAGSVLFSLFWSVQGSLLSWCFLQLKSTDSGAKELAMDLIEKYVG
QFLASMRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDISHCTLLREFS
TLTELLKKLCSDPEG-GPNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKSYS-----------------------GEKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAV
PQAKMASVLNSPLWKHVFRHQISPELELEASWSTHPHQDGKEVKNIPDDPCHHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSEGKIALSEEFAQVYSLADGIRIWML------------EMKQKSLVSLGSETEEKH
GLE-AAEVNPESL--AKECIQKSLLLLKFLPMGKSSKENNDKLVPV-DETDHL--QPLDR
RQRTSSVVEEHFQASASPTEAA-LPTPGD---KSPGLQSQPK----------LPPSSGPS
ATEVS--TTEEPSSPSTPSRRPPFTRGRLRLLSFRSM--EEARPVPTVKEKYPMLKDVMD
FIKDQSLSHESVVKVLSLRKVQAQSILEVLRIIQYCTESLGQPHCFHLPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVRAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTST
-EDMDGEQLDPEARSNAATLRSQCMQLVGDCLMKAHQGK--GLKALALLGVLPDGDSTLG
---NQALPATLLTQTSEHCYL----------TNVG--LL--------------IP--EKR
-SEDKEI-RPLDYKQKK---T--NEDLS-LMKDPSCQTQISDASAN-VHMTPEFPA----
----KKP-SSEVPVEEKTVTPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDTAVIKVLSAKPNLFATADN
-AVVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVVILKHFTEKN
RAVIVDVQTRKRK-TVKDYQLVQKGGGQECG-----SSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEE-VDRPISNPREPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHIIRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSRSLRLEEQSAKAVDTDMIILPCLSQPAHSDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHVPVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRESMLG
TMALAACQFMEEPGMEVQMRESKHPYNNNTSFEDKVHIPGAIYLSIKFDPQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVQCCTHSDLCD-LALLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLLQEYLLAL-----TTEDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLAAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPEMDKL-KSVAKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESSFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFTGLDLQIF
WNFYSKLKQNPREECISAQTLLLQLLQSCFSVLQGDVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
RSE-ATEANPESL--AKDCIEKSLLLLKFLPTGIRSKESCDKLETADET-NHL--QPLEK
RQRTSSVVEEHFQASVSPTEAATP-ATGD---RSPGLDTQPK----------LPSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDAYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDE-----
---DQALPATAPTQASEEQLEKKTVQGAELSEAE--PST--------------RCNIGKR
-AVHEEV-RPADFKQRS---KAD-KGVL-LTKDPSCQTQISDSPADAST----PIGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPISSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELTT
DERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYRFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCGHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSHSSEDEAAAAGGEGW-GP-HQDWAAVSGTTP-----------
GPGLVAP--ALPPAAALLEPARLREAAAALLPTPP-------CESLVSRHRGALFRWLEE
RL------GRGEESVTLEQFRELLEARGAGCSS--EQFEEAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLDAHSSMILRFLHRNRL
SSAVMPYPMLEHCKNMCTMRSSVLKESLDQLVQKEK-ESPADLTRSPEMDKL-KSVAKCY
AYI

PF03256 // ENSGT00890000139411_0_Domain_1 (304, 429)

ETSSNSADIDKMTNGETSSYWQSD--GSACSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAF
ALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSS-SDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLSISGYLRPARAEAEQ-S
VTCAHCRKDTEESVCGATLLLRTLQFTQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECIAAQTLLLQLLQSCFSVLQGGVLAASEEEKPPIQSPKG----VEA
AKELYTHLCD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFT
MMKNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLLSV
AARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSSDSGAKDLAVDLIEKYVG
QFLASMRVILESLLSQYSGKIIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFS
VLTELLKKLCSGPEG-GLRKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEASVFVSPG
ATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSHNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVH-QLGSNMAI
PQAKMALVLSSPLWKPVFRHQICPELELEASWPTHPHQNSKEVKNIPDDPCRHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQ
KYVNSGGKIALSDEFAQVYSLADGIRIWML------------EMKQKSLMSLGNEAEEKH
SSE-ATEANPESL--AKECIEKSLLLLKFLPTGIRSKESCDKLETADET-NHL--QPLDK
RQRTSSVVEEHFQASVSPTEAALP-ATGD---RSPGLDTQPK----------LLSSSGLP
AADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSM--EEARLVPTVKEKYPVLKDVMD
FIKDQSLSHRSVVKVLSLRKAQAQSILDVLRITQYCAESLGQPHCFHPPFILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLND---RSLLPALSCVQT
ALL-HLLDMGWEPSDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSE
WMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDHCQGLIIGRRMNCNVCDDFDLCY
GCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLTSA
-EDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPDGDSTPE
---DQAVPVTAPTQASEEQLEKKTLQGAELSEAG----------------------NGKR
-AVHEEV-RPVDFKQRN---KAD-KGVS-LTKDPSCQTQISDSPADAST----PKGLPDA
ED--SEA-SSQKPREEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGP--TVPLVDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDS
-TIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLVQKGGGQECG-----DSQAQLSQYSQHFAFITSHLLQTS
MDSHCPEAVEATWVLSLALKGLYKTLKAHGFEE-THATFLQTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEMNALAEHGDLELDERGDREEEV-ERPVSSPGDPEQKKLDP
LEGLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWQPGKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISS
TESELQQSYAKQRRSKSAALLHKELNCKS-------K-RAVRDYLFRVNEATAVLYARHV
LASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHSFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCSHSDLCD-LALLKPLWQLFTHMEYSLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGVLQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATR
LWNVEC

------------MGNAPSNSSEDEAAAAGGEGW-SQ-HQAWAADSGTTP------GS---
--ECK-----------------------------------------------FYREWVE-
--------------------------------------ERAFAQFDAEGDGTVDAENMLE
ALKNSS-GANLQG--ELSHIIRQLQACSLVPGFIDIFSESKEGLGVHSSMILRFLHRNRI
SSTVIPYPLLDHCNNMCTMRSSVLKESLDQLVQKEK-ESPGDLTRSPETDKL-KSVTKCY
AYIET

PF03256 // ENSGT00890000139411_0_Domain_1 (306, 429)

SSNPADIDKMTNGETSSYWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAATDQS
YMPQQVTVAVGRSAGDLQEVRDVHIPSNVTGYVTLLENANISQLYVQINIKRCLSDGCDT
RIHGLRAV

ENSGT00890000139411_0_Linker_1_2 (429, 1903)

GFQRVKKSGVSVSDASAIWYWSL---LTSLVTASMET------NPAFV---Q
TVLHNTQKALQHMPPLSLSPGSTDFSTFLSPSVLEEVDSFLIRITSCCSTPEVEQTLLAF
ALARGSVAKVLNSLCTITDHLDTQYDASSLISSMASVRQNLLLKY---GKPLQLTLQACD
VKGKEDKSGPENLLVEPWTRD-GFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIG
AQCGLVFAYNSP-SDKFHAEEHFKRFEKYDKWKLYELRQFIKSRIGCSADDLGEDDPIGW
FELEEEWDEADVKLQQCRVAKYLMVKFLCTRHESAERLGVQGLSISGYLRPARAEAEK-N
ILCAHCRKEA-ESVCGATLLLRTLQFIQQLAHDL--VQQKESGLKYKSFLDFAGLDLQIF
WNFYSKLKQNPREECICAQTLLLQLLQSCFSVLQRDALAAP-EEKPSTQRLRE----VEA
AKALYAHLFD-------VVDRVDGDSVPMEILKQEVRNTLLNGAAIFFPDRQTRRNHLFT
MMKNVSEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPERSDLAGMNISEVLAVMNTLLSV
AARECELLMLNGAQGEISSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKELAVDLIEKYVV
QFLASTRVILESLLSQYSGKTIVEKLCNSVFSMAARQLVIFLLDFCTLDIPHCTLLREFS
TLTELLKKLCSDPEG-GLNKLDVETWQQ-EQPVVLHTWTKESAHNYENNCHEVSVFVSPG
ATYFEVEFDERCETEKRYDYLEFTDARGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVSRLMGRLSSQCMALKSAH-QLGSNMAI
PQAKMASVLNSPLWKPVFRHQICPELELEASWPTHPHQDGKEVKNIPDDPCCHFLLDFAQ
SEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPELYEKLQ
KYVNSGGKTLLSEDFSQVYSLADGIRIWML------------EMKQKSLMNLGSEAEEKH
GLE-AAETNPESL--AKECIQKSLLLLKFLPVGKSSKEHCDKLVTA-DETDHL--QPLDG
HQRTNSVVEEHFQASASPTEAS-PLTVGD---KSPALDIHPK----------LPPSSGPP
AAEVS--AAEEPSSPSTPTRRPPFTRGRLRLLSFRSV--EEARPAPTVKEKYPVLKDVMD
FIKDQSLSHESVVKVLSLRKAQAQSILEVLRIIQYCTESLGQPHCFHPPYILFLLELLTC
QKDFTNYFGHLEGCGADLHKEIRDTYYQFVLFLVRAIKGFNSIND---RSLLPALSCVQT
ALL-HLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDNVISQWSEEDELADAKQNSE
WMDECQDGMFEAWCEKIAQEDPEKQRKMHMFISRYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCSDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHGDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEFTCDYCQGLIIGRRMNCNVCEDFDLCY
GCYATKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLAST
-EDVDGEKLDPQAHSHATTLRSQCMQLVGDCLMKAHQGK--GLKALALLGILPEGDSTVE
---MQASTVT---------------------------------------------KVGKR
-AIDKKI-TPLDYKHRN---MA-DEGLL-IMKDPSCYTQIKDVPAD-ANLPS---GLSAA
EN--SEE-SSQKPIEEKTVTPNPEQVFAECSQKRILGLLAAMLPPIKSGP--TVPLIDLE
HVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDN
-SIVPDGWKTTHLLFSLGAVCLD---SRVGLDWACSMAEILRSLNSAPLWRDVIATFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---QVLCVGTRCVYMDNANEPHNVIILKHFTEKN
RAVIVDVKTRKRK-TVKDYQLIQKGGTQENS-----DSQAQLSQYSQHFAFIASHLLQTS
MDSHCPEAVEATWVLSLSLKGLYKTLKAHGFEE-TQATFLHTDLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEINTLAEHGDLELDERGDQEEEVEQ-LVSSPGELEQKKLDP
LEDLDEPT---RICFLMAH-DALNAPLHILRAIYELQMKKTDSFFLEVQK-RFDGDELAT
DERIRSLAQRWHPSRNLRLEEQSAKAVDTDMIILPCLSRPARYDQATAESNPVTQKLISS
TESELQQSYAKQRQSKSAALLHKELNCKS-------KR-AVRDYLFRVNEATAVLYARHV
LASLLAEWPGHMTVSEDILELSGPAHMTYILDMFMQLEEKHQWEKILQKVLQGCRENMLG
TMALAACQFMEEPGMEVQVRESKHPYNNNTSFEDKVHIPGAIYLSIKFDSQCNTEEGCDE
LAMSSSSDFQQDRHNFSGSQQKWKDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVVPHLPLAKIWEWLVGVAC-RQTGHQR
LKAIHLLLRIVRCCTHSDLCD-LTLLKPLWQLFTHMEYGLFEDVTQPGIL-LPLHRALTE
-LFFVTENRAQELGLMQDYLLAL-----TTDDHLLRCAAQALQNIAAISLAINYPNKATH
LWNVEC

------------MGTAASHSSEEEEEGAEEG-------MEAAAQPGDPF-----------
--PAASPAPPLPPAEVLLEQARLREATARLREAAL-------PESLVSRHHGALVRWLEE
RL------SRGDEAVSLEQFCEVLESVSRLTAGSRGESEEAFAQFDAEGDGTVDVENMLE
ALKNSS-GANLQG--ELSHVIRQLQACSLVPGFIDIFSESKERLGLHASMILRFLHRNRI
SSTAIPYPVLEYFNNICMMRSSVLKDSLDRLLLKER-EYPSDLNGNEESDKL-KSVTKCY
THIETSS

PF03256 // ENSGT00890000139411_0_Domain_1 (308, 428)

NSADIDKMTNGETTSFWQSD--GSARSHWIRLKMKPDVVLRHLSIAVAANDQS
YMPQQVTVAVGRNASSLQEVRDVHIPSNITGYVTLLENANISQMYVQINIKRCLSDGCDT
RIHGLRA

ENSGT00890000139411_0_Linker_1_2 (428, 1903)

IGYQRVKKVGVSVCDASAIWYWSL---LTSLVTASMET------NPAFV---H
TILQNTQKALQHMPPLSLTPSSTDFSSFLSPNVLQEVDSFLIRITSCCTTPDVELTLLAF
ALARGSVAKVISSLCTITDHLDTPYKASSLIASMATVRQNLLYKY---GKPLRLTLQACD
VKGKEDKSGPENLLVEPWTGD-GFLTETGKTRASIILSTGTESSFQVTQIRIKVRRGAIG
AQCGLVFAYNSA-SEKFHAEEHFKRFESYDKWKLKDFKQFLKNRSGSSSDELGDDDPIGW
FEVEEEWDEVDVRMQQCRVAQYLMIKFLCTRQDTAERLGVQGLNVLGYLRPMREEPSR-S
MHCLQCRKTDDETVCGTTLLLKTLHFIQQLAQDL--VQQKESGLKCKSYLDFTDLDLQLF
WNFYNKLHQNPREECIFAQTLLLQLLQSCFSVFTGDNKTSKPQETLQ----GRTPGHTKA
AEDLYRHLCE-------VVDMGDTNFMPVKMLKQEVKNTLLSGAAIFFPDRQTRRNQLFA
MMKNITEQEHKQSVHLAFRSLCTHFSDQDPGGLLLLPEKGVSANFDISEVLSVMDTLLLV
AARECEMMMLDVAQQESGTVLSSLFWSVQGSLLSWCYLQLKGSDSSAKDLAVEILKNYVG
QFLTNVRMILQSLLSQYSGKTIVEKISNSVFAMATRQLVIFLLDFCTLDIPYCTLLQEFS
TLVEPLKKLCSEPHK-----MEIESWQQ-EQPVVLRTWTVESPHNYENNCHEVSVFLCHG
ASYFEVEFDEKCETERRYDYLEFTDARGAKTRYDTKVGTEKWPKKVTFKAGPRLQFLFHS
DSSNNEWGYKFTVTAYGLPDVAVSWGLDLQLLVCRLMGRLASRSMALKSQR-ELGSEADL
PPLKVTSVLNSPLWKPVFRHQMCPEAEPGASETSRGHQDKKEARSSHQDDCRNFLIDFAR
SDPAQDFSGQKSELFKGLVQTCRKQTPKTDTVAGSTVDRAVNSTFAALVYLTPALYEKLQ
KYVNSGGKVPLSDEFAQVYSLADSIRIWML------------EMKQKSLMGRGNDTEEKQ
STE-ASEVNPETL--AKLCMQKSLLLLNFLPVRVKTKGSTSDSLEAQDGDN-VHQYVNDR
NQRKSSVVETDFQAAHSSSSSGVTRSVSVEGEQTTQSDTKIKQISDPLQTEEVSAFHSKP
SENTALQQEDVPSPPSTPTRKSQFSRGRLRLLSFRSM--EEPRAVPTLKEKYPILKSILD
FIKDQSLSHESVLKVLALRKSQGQNILEVLRTIRRCLDSLGQPHCFHPPCVLFLLELLAC
QKDFTNYFGNLEGCGAALHKEIRESYYQLVLFLVNSVKGFSAITD---RSLLPALSCVQT
TLL-HLLDMSWEPTDLSFFVEIQLPQLLMATSQENISIHDSVICQWSEEDEIADYKQNCE
WMDECQDIMFESWYEKIAQADPEKQRKMHMFVARYCDLLNVD

PF00569 // ENSGT00890000139411_0_Domain_2 (1903, 1934)

ISCDGCDEIAPWHRYRCL
QCNDMDLCKTCFL

ENSGT00890000139411_0_Linker_2_3 (1934, 1952)

G--GVKPEGHEDDHEMVN

PF00569 // ENSGT00890000139411_0_Domain_3 (1952, 1993)

MEYACDHCQGVIIGRRMNCNVCDDFDLCY
GCYSAKKYSDSHLPTHSITVYPMVTIRISDRQRLIQPYVHNYSWLLFAALTLYSADLANG
-EEVEGEKLDSQVLSHARILQHQCIQLIGDCLMKAQQGK--GLKNLALLCMLPEGESLSE
ND---TASVSPPTDGAPKS-HTGD-----K--AGKGKDE-KPSTGSFM------HSNEKG
ETL-NEIQSPAGDKVQKHGSESDRNAVS---AKKAVLRQESELSMEDNIT---PT---DD
CI----SEDSAQKQAEKVLIPSQEQVFAECSQKRILGLLAAMLPPFKSGS--TMSLINLE
QILPLMFQVVISNAGHLNETYHLTLGLLGQLILRLKPAEVDAAVAKVLSTKHSLFAAGDP
-STVPEGWKTTHLLFSLGAVCLD---SRVGLDWASSMADILRSLNSSAQWHSVIAAFTDH
CIKQLPFQ--LKHTNIFTLLVLVGFP---EVLCMGTRSVYMDNANEPHNVIILKHFTEKN
RAVVVDIKTRKRK-TVKDYQLIQKCEQEGSDS------QAQLRQYLQHFVLICTHLLQTT
IDSSYAEAVEATWVLSLALKGLYRTLKIHGFQE-VQDAFLHSGLLKLLVKKCSKGTGFSK
TWLLRDLEILSIMLYSSKKEISSLAEREDTELEEREQDQDV-EQ-SIVGPADVEQNKLDP
LEGLDEAT---KICFLMTH-DALNAPLHILRAMYELQMKRTESFFLEVQK-RFDGDVITT
DERIRTLAQKWQPSKRLRLEEQSSKAVDTDMIILPCLSKPVLCDKATEETNPVAQKLITN
TESDLQLSYAKQRRTKSSILLHKELDSRS-------K-KAVRDYLYRVNEATAVLYARHV
LASLLAEWPDDVAINEEVLDLSGPAHMTYILDMLMQLEEKQLWEKILQKVLLGCNESMLG
TMALTACQFMEEPGMAVQVRESKHPYNNNTNFEDKVQIPGAIYLSIKFDSQCNTEEGCDE
LLMSSSSDFQQDRHSFSGSPQKWNDFELPGD-----------------TLYYRFTSDMSN
TEWGYKFTVTAGHLGRFQT-GFEILKQMLSEERVIPHLPLARIWEWQVGVAC-RQTGHQR
LKAIHLLLKIVQCS-AQRDCD-LTLLKPLWQLFTHMENNICHDVTKPGIL-LPLHRALAE
-LFFVTENRVTELGSLQEYLLA---L--NSEDHLHRCTAQALRNIAAISLAINYPNKSTS
FWNV--