Query Results 

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSQRETKEGARIVVEVDDKVAKIRNLKVDSRPDGFGDSREKVVAFG
FDYCYWSVSPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTP-
----------------------------------------GLFIKEEDCVSLPSSCNIKV
SFLEIYNERVRDLLKQSDKKKSYTLRVREHPERGPYVQGLSEHVVTNYQQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILDNNCPSEMASKINLVDLAGSERADPNYCK
DRMTEGANINKSLVTLGIVISTL-AQNSQMFSNCRILSSTA-SNGGDCGIPSSSSGTSSR
GAPSQRWSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYNETISTLRYASNA-KS

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELKEEIKRLKAMLLSFELM------------------------
-DKLIKEWTQKWDDWQTLMEHYNVDISKKRAGVLIDSSLPHLLALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPTQGARCTVNGREVTAACR
LTQGAVITLGKAHKFRFSHPAEAAVLRQR-RQVGEAVGNS--GSLEWLDLDGDVTASRLG
LCPVLWK-ERKLLGEPRDRKHQSPRDGE------IQ--QQQCYVEDLRQEILAGQIRAEK
ELESSRACVHQQTKGNQQWLLRQEPWLASLQEQQ-----ADRGAGE--------ELEVSV
APDAWIQTGLETPPTPLVRNQ-KRVVRLQFLRRHALRVAERSIRRRKVS--FHLGRIIKN
QRLQEAQRRLELISTPCWPQDDSTWKSPCQIPLV------PVPR-HRSRWASCCSLGV--
QKFC---NG-FP-------------YLHSIFLNWDPPTTLLLMPNPTH----QKPDKAPP
APPFPLRI------R--------------HLCRRN---PHPTASTPDPCLTVSSHE----
AMDIQEVERVGKQPCQMASLGFMSL-------KPKDR-LKTLTPVIQTRTA-----S---
-VSPQAEWQKDW-DLGTHKPA------KGAICCP---------LYSHGPKQAAGHGKGTK
TFQ--AKAKPTFPNKTTKRQQK--VLAARVRDIARQSFHLPHGNPLRRQPNSGNPDSMTA
LPDSSPVVDHTREE-NDLSDADSNYSVDSLSCVCAEV-QREPPKSEDPQG-KWSLPEPEN
SESDNSQISEDSLAENGYQCPNEFLRDNHPT-NHG----HPRTRTTASLRGFCT-PLDCG
PCAQAHRGFSLDSLIRAEE------DQQEEPCLGSVDEMPAETFWHLPNSAFPVGDQ--E
AASRPGLIDHRIE-AKLNAVLPMSSSCYLDPHFQP------------------RCECLKS
EVEAGYFEQAGSSQC-TQLLRGS---PLVSTDSWFSCDSKINSGSPPGVVSSLCASPDIQ
EAQPCAEEKTGYRLTTEEQKPSGSS--------RLLQGGPEPPCGARDP------Y----
-----------PAS-TSDPPKLPAWEAQRLH------------PGIF--EGREIPVITQQ
GGSEASHSSSVSSMLASSATSF---IHVESLPERDW------DSLQQKYLLELSHPVSDA
VGELKQ-----ALFCPKEDS--GSLAEASGKKGDTGVPVGSGISSNLNVNNFLVHLSRTT
HLRTEKDQVSSSTKLESASDFLSTSDKEVSCHGAYS----ADVESLT-SASAH--VQVQT
AKSKVPHSVT-----GAHEGGQNNLEE-GFHGS-RKRVLLTSSD----------DNGT-V
ATKAEDWLPDQALFRKKSDSQAGPLSQSS-HP-PPLREEKNHCQESAD-KAGRRHKNIS-
--FTSPSVPELHLHSAPWNPFPTS-LHPPPLETFYTTKSRDALTETALEIPAYREVRGPS
PSPREAWGFHPSHQDLQEPHLENSLPMSSQSHDLKMASFH-QVTT---DRSVDLCAREVI
GKLEECLGNIE-E-----SH-----------------------SSVYCFFAHNRHCVPST
STQVCEFESQVGILNIE----QHGER---EK-AP-V------QSLCSASLDSSES-----
-------------VSAQVCWCPSEAEGEEDPGP-------SVVVLQAQPREKGRQSLSGL
RSGFVCETTDLGLEKDIP--LTAS----AALMSRSGQHRMK--KTMSQGNSPAHTW----
EGKNETGLVGKALYPKDSPEECKLPGLES-------ACEG--VRSVKCSK-KRHP--GGC
KGPRK-SQV----MVGI--KGEPCEKKHTQNTT--SADEMDKLIRSVRQ--LENSISEIE
SQQNNRLHASHTPGVSKESMFQDQ-NHR-RTGHPLR---PGSSAIHLSYKE-PSVPRQID
DAIFR--YSKAGGV--EVYS--------CHRVTT----SPFRSSEHAQDCQSVGAHTHTA
DVALDRVSRGTC--NP--------------SGRGTAQGE-----STNTTLHLGR------
------------MKKLARALPTRLEGS---GKDI-ELGGE-----S--AN--SKEQTWDL
ESFEELETV-----KGFQMNQIAECSSGS--------------EPEDPVVQGRLEQMARK
SRRCPLKENI-DLIKTQKLLNPSQ-HCLDTVSSQETAFPLLTQTDFS-ATTYCQDLRNNS
LPLGSPRLPRNHLHASD-SLNMSSVE---TLLDPTMLKIHESP-LGTRVGH-QDQSGG--
TGSPEG-SVS-----------------------------------GGFSMPPTAWYGSEM
PT-------PMESDGQSVISDS-SIPLGTEDWMTSSTSS-HDQGRDLRIALMALSTQEDL
GSETEAAIPKK--RSSSLNRISGRLEKRVSFLLEEDTDQSGE-TREK---TEEA-EDP--
--GP----------------ASSTSLEPISLP----------------------------
-QEPEAEPMLSD-SSVHASMCL-----AILKE----------IRQVTTQRKQLGDFAMLG
TVLPHYEMSLEPESSLGTTE--ICWQMDP----------LQVLDRTQNEDEAQGL-----
SATPGHL--SPDEPE-V-QA--------TLL-CEDDFQPRSDSEMNEG------------
-PRHHSRASSPRAT--S------DKEL-RYVLEASEQFVCHSSS-ETTGMEEEAPRAPSS
ADPWVS-HRLSSDMER--------------------------------------------
----------------------------------DRRVSSQAPCCDPGRAPQ-----RQS
HL-AAWETEDGTFSGRWDNRPGLREP--KRPESPYG-----------SGSSSFFVAAQG-
GK----------RAHVERQPMVCDFHSATSLPGPRADAIQCPEASSTDLEEAMTSAKHPA
VLAGALRKVSM-----GAPKQQHVKWKEKTESMLPEA-CR--------------------
AGGKAFR--PT-------------------------LPNQRPRPDPRGVGEE-PPCACQT
ETLASFVL-ESPEDSGPLGLSRKEEESKAFPCQPLGS-ALI-AGNVCTFHSSPPLCARDG
DPRKGIARA----HHSSFIEPSRFCEMDE-GEGSSTEPDMPLAHSL----ELKERN----
-VDSSPLEPSTTAAGLSRTQGCSSSFT-PGTR-ASSFTPSTADGSSGLVGDPEKKGS---
---T-------E------LEGSYLEAPRTLTESSIGDQHGQAAD-MEPEPP--VTAWGLH
SPNGSKGFTVSELAVE-EQHRQLENT-IRSLLEKTQP-------KS-LDPQAKCV-RLKH
VCSP--QAD-CAWEEEEQQRDEPS-GE-KDSARHRN-----PPPSDG-------------
DA-----------------EAAMTNSPVFQSFFSGFEDT------QSEVPQPAAWRPG-Q
PCSDRKQPAP-HHRHSHPIIAVFSGPQH-FKSSSRPRFSVINSSRSLQELMSK-A-CPCP
REGDL-QSLC---P---SHRSSRKPMA------RAALRAEDSNQMVLSNFY----SSSAD
HGAQKPVTPPY---PTLPTCSC-------MPAP---SFVSSCMYSSWE--QAPQ-GKPET
LGVQVRPENCFSP-VDKGMLTLDSSDSTPSIPPLSPDGSVCIGWKQYVFGSTADLLFSQK
-----PSNVAHGTG--MDSGLEDQNSPLKSQVGAHA--RTLSRTHRSTEHAQSC------
----------------------------------------------VEPLL--AEENAAT
PVDRAGLLGRAE-AHPGGL-ARRNTLEQGTQTPG-CR-------RRWSCTDIS-TQPDSD
RRPAC-DLASWSSMHSLSLRLSQLLHNTSQLLGSLSQPNVASRKQTTN--VSAPEEALP-
-VLKMEGATQTTLDKGTQTDLISP----------FPPAP-APGTKPPEVNV-SLEVLAS-
---GIKTTS----------LGKGDTPVALEKREA-EETPPK-MAA-----SPEVH-----
-EGRC----QSPPT-PLSPLRLQKVSLE--QSLPSVSPLASE-AAPPPAPQPGCPG--MD
NSPHI------PCPLRLVPST-PDFPLEL--GVQKQP-GPAS-ATVDRASSPILILSASC
QESDP-------AQPPST----PPPGGHLGPS-TS---PQLGP---SASRPPGDEGPDGL
DGSLSI-------EAQSQGQKHS----ERS-----TDSFLLEPSSPRSPRR---------
-----------RSRVQAA--GQPQ---QPSPTPG----------AQC---------RQPS
PTPGPS-----------PTPEA-QC-RQPPPVNSTGA----QCR------QPSPTTSTEA
Q-PPLQPLP-WSAD-------------------------------------TAES-RGPA
SGSPHACRPQKLLRS---ISHMCLVSERQHHSQRDR---------YGVQDDSSGGLGMSE
-KLRT----CS-RQKRR-RPPQL---------PCDQSHNAEWSQA------KPIPLQTGV
HKPSLSMELMEAKLHHGFGEVDALLQVLQNGTGEALAPEPPA-GSWE--ELYTRQ-----
----------RKAIETLRRERAERLQHFYQTQNLCPKKQLNLQLTHDPPTWEPDLPSRRR
EYLQQLRKEVVETTRSPEEASR-SAEQTCDIELMLRDYQRAREEAKLEIARARDQLWERT
EQEKLGIRQKIISQLLK-------EEEKLHTLVNSSPQSTS-SNGSLSSGITSGYNSSSA
-FSGQPQSPEAMG-D------------------TDLSDS--RDTWLGEGQCRPAVRNSHL
DVAGSAWKSSVY-----SRRASLGS--CY-S--------QSSISSLVNCF---SASSYQE
LAKHIVDMTMADVMAACSDNLHNLFSCQATAGWNYQGEEQEV---------QVYYKEFS-
-STRHGFLG--AGVVSQPLPHVWAAVSDPTLWPLYHKPIHTARLHQRHNLGL--GYYTDH
T----LNSSSELTALCS---------QGHLSIMAAQSVYDTSMPRPSRRMVRGEVLPSAW
ILQPVSVEGKEITRVIFLAQVELGAPGFPPHLLSSFIKQQPLVVAKLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVTKGYNISVFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSSQKKSYALRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTVHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQFFIPYRDSVLTWLLKDSLGGNSKTIMIATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-TSLNDEKDENLKKLVLQNELK
IDQLTKDWTQKWNDWQALMEHYNVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LSPLLWK-EERVLEEQCDEDHQPPRDGETSRSAQIQ--QQQSYVEDLRQQILAEEIKAER
ELELDQACISQQIKKNQQCLLREETWLASLQQQQ-QE---DHVAEK--------EVEGSV
ALDAWLQTDHEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAEQNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQD-------YDA--IVPEPR-CRSRSSSCSSLSP--
ERLC---SKHVPQLQS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EEHLPQAASYPPRAGHLHKNGL-HSLGHGQHYTARAAKARKGASAPDTCLTMSSKS----
-LGIQEMRRVGKQPCQMMSQGLVSLRQSANELKPRDE-PKILTSTTQTRRAKGLADP---
-RHTQAGWQKEG-NLGTHKSA------MGASCSS---------PYPHGPKTTAGCGKAVK
TFR--MEYKPPSPSRALKRHQR--VLAARVRDITKKSSHLPLGSPLKIQQNARDPDTMAP
LTDFSPVEDHSREKDSDLSDTDSSYSVDSLSCVFAKA-LIEPLKPEDPQGRKWDFPEPEN
SESDDSQISEDSLAEKSTKSSKDRLWGNHPTNSHG----HPRIRTRAFVRDFTA-PSESD
LLAQTHKSFSLDSLIDAEE--ELVEDHQEEAFPGSADEIPTETFWHLDNSNLPLMDQ--E
AICRCGPINYRTG-ARLDAVLPMSSSFYLDPQFQP------------------HHEQAES
QVEPSYPEQADYLQG-IRLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFQPCDGERPGYWLNTEELKLSGAETVP-PDSSKLHQGSTELLCSARDE------H----
-----------RTS-ASDKSRLSLWGVQRLV---QPG-----ADGTF--QGRGIPDMTQQ
GRSEASHSSSVSNVLAASATTL---THVGSTHERDW------SALQQKYLLELSHPVLEA
VGEPRP-----AFPYLEEDS--SSLAQAPSKGGDILFSVGPRVSSNLDLNNFPLHLSRIR
HLRAEKEQDSLNAKLEGVSDFFNTGEKVVSYDETYS----ADLESLTACGSTD--AQVFA
AENMIPNSMA-----EACEVKQNNLEE-CLQNC-RKPGLTTSSDECFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPRQLSSN--SH-YPLEEEKIDCQESSE-EVVRRHV----
--FAFPSGPELYLHSAPWNPFSPS-LQPPPLETFYVTKSRDALTETALEIPTCREVRVPS
PPPREAWGFGHNHQVLQNAYLKDNLPVLLQNQNSKIASSQ-QVTA---E----MNTREVI
RESGKCPGNII-E-----ESC----------------------NSVYSSVTQNRHFFSST
STKVCEFENQVGILSKKHSF-PSLEG---EE-AT-A------QSCCSASSDSTVS-----
-------------GKPLALFCESEAGNEEEL----------------------------D
PNTVLRQTISVGLEKDMP--GEST----VSLKSRSVYHRVSSPVMVAQDESPTPKW----
KGKNETRLFGKALHPKDSSEEVKLPGTKP-------AYER--FRLVTRLQ-ERNS--SEC
K-------E----MLNP--KGEPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQSKQVHASHAPGVNKEFVFQDQ-KEQEKTDHALR---PDSSGNALPSKDQLFSPRQTV
DTVIR--DSEAGEM--EINN-AG-NHPLVQKTTV----NPLRSRKGVQENESVREHTH--
PAGSDRSSRDIC--AS--------------LGTHTTFRE-----FTNTFLHPQR------
------------IKALARALPLQPRLGRSSENDG-QLVKA-----S--AS--LRGQPWGL
GSLEELETV-----KGFQESQTAEHIS-S--------------NQEEPKAQGKVEEMPMQ
RGGSLQEENK----VTQKLPTLSQ-LCRDTFFSHETVSPLPSQTECS-TAPSHQDL-SNT
LPLNSPRLPRSCLHASD-ALGISSLD---CVLDLTMSKTHNSP-LVTGVEH-PDQSAETK
SHSPEG-NVR-----------------------------------GGSSEARTAWCGSVR
SM-------AVVSHSQSGIPES--IPLGTEDRISASSSP-QDQGRDLRITLIGFSTSEDF
ASEAKVAVQKEIG-VSSLNKVSRQPEKRVSFSLEEDNDQGSE-PRQE---EEKETEDL--
--RL----------------TSSVFLASVSLP----------------------------
-RMPNPEPRLLE-PFDHASMCL-----AILEE----------IRQAKAQRKQLDDSVARG
TVLSYCETLLEPECSSSIAGRPQCKQID-----------QSSSDRTRNEVEAPGFHVTSL
SAEQGHL--STDERK--DQG--------TSL-FVDSFQPLPNTGTDRE------------
-PWHPVQAFSHAAS--ALDKKHCTGEL-RQFAGAGEQFLRHSSS-ENIEKKKDATRTLPS
ADPLAPDSLY-LAPVEG--VRRVVSK-----------------------------MV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGT--GSQDSSPEHQEP--RTLYTTYG-----------EVSNNLLMTTQG-
EK----------TAHFESQSVICDVQKSTSPSGPRQDHLQCPEASTGFEEGR-ASPKQDT
LLPGALARLEL-----EAPIQQCVKWKESVGSGLTEV-CR--------------------
TGSKHSR--PT------------------------PLPDQRSSPSPEGIGEG-VPCRYPR
EALDCPVFSRNTEGSRTLSPSRGE-ESRTLPCQQPSSSQPV-TTHADSSHFSTLLCYRGG
DLGKELFKVAPHSVHPPCVAPSRAFEMDERREFSSRGPDVHMTHGL----EPKDVNREFR
PTESNTCEPSTVAAVLSRAQGCSSPSA-SDVR-IRSFSHSATDGSLGLIGVPEKNVA---
---EKQAS--TELETASFTAGMHSEPLRQFRDSSLDGQNAQVSQ-TNPEPP--ATTQGPH
TLDLSEGSAESELVAE-PQHGCLENT-TRCLLEKPQFPTESRDNNC-MDFQTKFVVKLKH
TCSP--QDN-SPWEKEEQQRDQAS-GGGEGFAQGVN-----PPPSDK-GGSAGCQILDAG
RK-----------------EVAVAKPLMSKILSEGFKDPATVLLRQNETPQPVAQRPG-H
LCTGREQPAP-NHRCSLPVIAVFSGPKHS-KSSPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNSHLKGCSSGKSVS------RTSLQAEDCNQKGSSHLD----DDTAD
HRPPKPVTPPY---PMPSSLSC-------MSTP---DFMTGWLSGTLE--QAQQ-GKPEK
LGVQVRPENWCSQ-MDKGKLHFGSSDINPYSLSRCPEEPVRISWKPCVFGSAVDVSCSQK
PQGLTPSNVVRCSS--MDNGLEDQNSPFHSHLSTYANTQDLSSTHSSTENAQGSNEACEI
FSGTSSTALGNPHILTSPEGVAPTSV-HDRRPQFRSPSSEVD-CLRSKPPV--AEGGAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFKQGTQTLS-SR-------CHWSSSDISFAQPEAS
TVSAS-DLASWASMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTN--RDILDEAPK-
-AHMMDGSTQTTVDEGSQTDLTSP----------SLCLQ-ASVAKLQEVNV-ILAELGS-
---DISTMS----------QEKGDVPGVPQKREA-EETAWK-MAQ-----PPYRQ-----
-EESTPCKPQSPPIP-SSHLRFQKASPG--QHLPSVSPSVSDAF-LPHSSQPEESPCIAV
SSPSP----SPSHSPGLFPST-SKYPRHS--RVQKKL-GPPSALLVDRASSPILTLSAST
QDPGL-PPGFLTLSAPSV----HPVEDHQKLD-SS---PHPVG-A--PRTP-MDNYSQPT
NESGGS---QRG-------RSSL----QRN-----DRRTFLELGSPNSPQQ---------
-----------SPKFQVNFLGQPPQQLQPRTAIGVQS-------------------RLLP
PPLRQR----SQMLADSFVPEEVAS-PEHGPLIGREP---SQWWSMTENGGEGSTSPVEL
Q-CTLDLSS-SWRG--F--------QHLSP--CPVSEFT-------------AGL-QDSA
LGLPQSCQPEGLLCH---NCQMCMAPEPQHHSLRDLPVHNKFSNWYGVQKGSPGRLDLTE
-ELGASCDLSS-EKQ-EQSPPQP---------PNDHSQDPEWSQR------EQIPLQVGA
QNISLSVELTEAKLHHSFGETDALLQVLQSGTGEMLATDEPVISTWK--DLYVRQ-----
----------KETIQTLRREQAKGLQNFSQTRSLSPQRQLSLLPNKDRLIRDLDLPSRRR
EYLQQLRKDVVETTRSPEAVSR-SAHPAFDIELMLRDYQQAREETKLEIARAQDRLRERT
KQEKLRIHQQIVS--QLL-----REEEKLHTLANSSSLCTS-SSGSLSSGMTSGYNSSPA
-LSGQLQSPESVG-C------------------TNLTDS--WDSWIGDERGHSAN-----
---------SAY-----SELWAMLG--IATL--------PS---QDLHLF---IV-GRRD
LAKHVVDTSMADVMAACSDNLHNLFSCQAAAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTNSINLVYLVCD
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGREVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

------------------------------------------------------------
------------------------------------------------------MLGTPA
SVGLTP-RICEVQTLLTGYFQSRSLLSNPFSEIPTLWF

PF00225 // ENSGT00890000139327_7_Domain_0 (159, 421)

VQGLFTKEEDSASLSSSCRIKI
SFLEIYNERVRDLLKQSNQKKSYTLRVREHPEMGPYVEGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNFPSEIASKINLVDLAGSEKADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLKSTA-NTGGDSGIPV-SPGTSSR
GGSSQRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKAMLLSFELRNF-SSLNDEKDENLKELILRNELK
IDKLTKEWTQKWNDWQALLEHYSVDINKRSAGVVIDCSLPHMMALEDDVLSTGVVLYYLK
EGIT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGPLIERDHCIITNTCGAVILRPAQGARCTVNGREVTASCR
LTQGALITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKAQKFRFYHPAEAAILRQQR-QVEKTFGGS--GSLEWLDLDGYVTASRLS
LYPLLWK-ERRVLEEQYDEDHQPLRDGERSHRAQIQ--QQQCCVEALRQRILAGQITAER
ELAFNQAYISQETKDNQQWLLREESWLYSLQEQQQ-Q--EDCGTGK--------ALEASL
APNAWLQTHPDTPPSPLVPKQ-KRLVQLQLLRRHALRAAEGNIWRKKVL--FQLDRSIRK
QRLLESQKRLEQLRALCWFQDDSRHKSPCLAPNSNA--TVPGPQ-HRSKWTSCSSLSL--
QRLY---SQHLP-------------HLHRVFLNWDLSTMLPPMPDPTH----HISEKNPS
KYHFPQTAAYPPNTRCLCKNGL-HSPGQAQLYTARGALTRKGASTPHTCLTVSSES----
-VDIQETKRVGKWPYWMVSRGLTSLCQSTNKLKPREG-PKILTPTSQTRKAKGLVDS---
SSSTQAGWQKEE-NLGIHEAA------KGTSCSF---------SYPHGLREAARLGKIAK
TFQ--AESKP-PPNRALQQHQR--VPAARIRDIAKKSSHLSNSSSLKRQCSVDDPDTMTS
LTDSSQIVDCAKEKENDLSDTDSNYSVDSLSFVYAKSSLLKLLKPEDPRGK-WDHPEPEN
SESDNSQISEDSLTEKGYQSPKESPQSSLPTNDHV----HPRNRAGSSVQNFTT-SSDC-
-GLLAHRSFSLDSLINAEK--ELGKDQQGVTFLDSSDEMPTETFWHLQNPILPIVDQ--E
VTCRHGSTYHRTG-AMLNAILPMNSSFYLNPELQL------------------HCKQPES
QVEVSYSEPTDSLQG-IQVSRGS---PLVSMDSWFSCDSKINP-------SSLCPSPNVQ
EVQPCGEERPGYWLNIGKLKPLGTETVL-QCSSKFPQGSTELPCNARDV------Y----
-----------PTS-TSDTSKLSLWEAQSFL---QPA-----ADGSF--QGISITDTMQQ
GSSEVSHDSSVPTVLAPSAASF---IYVGSTHERDW------AALQQKYLLELSHPVLEA
VGKPRL-----AFPCPEEDS--GSLAEASGKGKDTRLSVGSGLSTSSDFNNFPIRLSKIK
HLRAEKNQDSLRAKLEIASDFLSTSEKEVSCNGAYS----ADLESLA-SGSEK-------
---RIQNSMK-----KTCEIKQNNLKE-CFN-S-RKPGLITSSEEYFLQNNAYHNNVT-V
STKTDHWPQGLAPLRNNSTVHPEQLSQN--SHHH-LQKEKVDCQKSSK-EVVERYTNVS-
--FAFPSGPELYLHSAPWNPFPSS-LQPPPLETFYITKSRDALTETALEIPAYREVHVPS
PPPREAWGFGYNHQDLQEACLKNDLPVIF--QNSKVASSQ-QVTA---EMPVDLKTREAI
GELGKCAGNIKEE------SH----------------------NSVYVFVTQNRHFLPST
STKVYESKNQIGILSKKHNLPALKEG---KK-AT-V------QSHCSVSSGSSGS-----
-------------GKPFIFVGGSETGGEDEQNQ-------NAVLQQIQVCDINGQIPSGA
RSDFICKTTSVDLEKDVA--GETT----VSSKFRSVHHRVSSHILMAQDESLTHKW----
EGRNEIGLLGKAFHPKNIPEEFKLPGIES-------TYER--FQSVTYAQ-ERKP--SEC
KGPGE-SQE----ISNY--KEEPLGKKKNERIS--NADEMARLIRSVMQ--LENDILEIE
SKQLHAS-S--TPGISKEFVFQDQ-RDQENGDHVLR---PGSSGNNLSFKDQPSSPRQAD
GIIFN--NSETREM--EVNSPTVDDPQ-AQRITL----SPFSSRECVKQSQSVREH-TY-
LAGLDRPARNTC--DS--------------LGKDSTHRE-----STNTSLHPRK------
------------MKTLTRALSLQPRPERF-EKGD-ELVDA-----S--AN--PKEQPWNL
GNLEELETM-----KGFLESQIARHQSSS--------------KPDRPKAQGKIEEMAMQ
KEGSLQDENN-MVLSTQKHPSSSQ-HPMGTFFNQETIFPLLSQTDFS-TAPSHQDL-SNT
LPLHSPRLPRSYIHSFVTEEGISSFE---YVLNPTVLKIHNSP-LITEIDY-QNQSGETR
SHSPQG-NDR-----------------------------------GGSAMEHSAWCGSVI
HR-------AMGSHGQSSAPEN--TPPGTEDRITASTSP-QHQQGELRITLMGLSTQEGF
GSEVEAAIQKEIQA-SSLNSISRQFEKRVSFSLEENSDQGKG-ARQK---AEKESEDPG-
--FP----------------TSGACLAGVSLP----------------------------
-RVADPEPRQS-EHSVPISMCL-----AILEE----------VRQAKAQRKQLNDFVAGG
TVLPCYETSVEPECSSGATGRQ-CKQMD-----------QLVSDGIRNEGEAQALHVASL
SATPRHL--LTDEGKSQA-I--------PLC--ENSFPSLPNTETNRG------------
-PQHPSQASSHVAP--ALDKGHCTREL-RHVLGASEQFICHPGSPEITEKKKEAPRTPSY
ADPLAFSGLFSP-AVEG--DRRVGS-----------------------------EKA---
----------------------------------VSVFSSQAPCDDPGLILH-----EQS
QS-AAGETAKDMSSGIQDSSPV-QEL--KTQDTTYE-----------GVLDNFSVSAQE-
KK----------AAHFESQSVICNVQNSLSCLGPKQDYVQCPEVSNGSEEGK-ASPKLHA
VLPGGLRSIEL-----EAPTQQPEKWKGNVGSALAET-CR--------------------
FGNINPR----------------------------S----------TPLQDQ-RPCRCPE
ETRDPLVFSGNTENSRTLSSSREEEESRTVPCQQLCNSQPI-ATHASPSHCSISLVYRDG
DLEKGIPKAALHPIHPPFIVASRVCEMHQIGESSSKESHVLLAHGL----EPKGFHMELG
PIDSPSFEPSTRTSVLSLAQSSSSLST-PDIR-TSSHIHSAAEGSSRSKGNQEEKLA---
--EK--AS--PEVEIVSFPAAMYSEPLRNLKDSSVCGHNVQASQ-MKPEPL--ATTHRPY
TLNLNESSVENELVVVEPQLKCLRKT-IRCLSEKLQSSAESRDHNC-SNPPAKLVTRLKP
ICYP--QID-SLWEEEEQQKDQAL-GGSEDPIQVRN-----SPPSNE-GDLDSYHTSSAR
RE-----------------EMSVPKTPESQTSLSAFEDLAFAPLEQSKVPQSAAQRPS-Q
HCFDKEQLAL-HRKCSLPVIAVFSGPKHS-KSYPRPQFSVVSSSRSLQELNLS-VEPPSP
IDEDA-SGPNILWDPHLKTYSLENQVS------RMSTKAEVCSQKVSSNLD----NGHAD
HRPPKPATPPY---PTSSTRSC-------MPTP---DLMTGWMSRSLE--QAQQ-GKPEK
LGIQIRPENWYSQ-MDKEMLHFGSSDINPYLLPWCPEEPVHIGWKQYVFGNTVDVSCTQK
PHGLIPSNVARCSS--MDSDLEEQSSPFHSRLSTFAKTQDLSSTHSSTDNIQGSNEAWEV
CS--SLFPLRDSHILTGREGLTPILG-SDKKTEFKGTIDEAG-CLRSEHTLPSAEGSSAG
LLDEIVLLYPPEADCPVGL-TRTNTFEQGTQTLG-CR-------LPWSCANISSAQPDAC
TGSAS-DLTSWTSMHNLSLHLSQLLHNTSELLGSLSQPSVGKKEQSTR--RNTPDEAPQ-
-ALMMDGTTQTTIDEEIQTDLALS----------PLDLQ-TSEAKSQEVSV-ILEVLGS-
---DISAMS----------QQKGNIPGTLQSTEA-EETSWK-MAA-----PPDLH-----
-EESTHHRLQSPLIPI-SHK----REVL--SNLPCISPPASPNASLPPSSQPEESSCMVV
NSPNC----SICLTPGLFPSTSGGSNQEP--EVQEKL-SPGSALMVDRASSPILTFSAST
QESGLL-SGALILSAPSD----YALESHQKLD-SS---PDLVF---GVPRPPMDNYSQTA
DKLGGS---QRVETLGREGTSSL----RRS-----NESLFLESNSPCTTQQ---------
-----------SPRLQVSLLGKPPQQLQPRATTEVQS-------------------RLPP
LPPWDK----SQRLANSFVPEEVAS-PDHSLLSTRGP---SPLQSNPENEGENSILPVEP
Q-PTLNLAS-SRRS--L--------QHFSP--HPVSELTD-----------TASL-QGSN
VDQPQACQPEGMPCP---SSQACIAPQ--RCSLRDLLVHNKLSNWDGVQNDSFGELSISK
-ELGAITDLSP-GEQ-IQKPPQP---------PDDQSQDPEWSQR------EQIPLQVGA
QKPSLSLELTEAKLHHGFGEADALLQVLQSGTGETLVPEEHMMSTWE--ELYARQ-----
----------KKAIETLRRERTERLQNFRRTR--SPPKQLSLLPSRDLLTQNFDLPSRRR
EYLQQLRKDVVEITRSPESASR-SAPSPSDIDLMLRNYQQAREEAKTEIAKARDRLREQT
EQEKLRIREQIISHLLR-------EEERLHTLANSSSLCTS-SNGSLSSVVTSGYNSSPA
-LSGQLQSPESVG-D------------------SNLPDS--RDTWIGDGQAHSAVRN--L
YLAGSVWKNSAY-----RYRTSSGN--CRCF--------PSSPSS----F---SS-SYQD
LAKHMVDTSMADVMAACSNNLHNLFSRQATAGWSYQGEEQEV---------HLYYKEFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVNKSISLVYLVCD
TTVCALKQPRDFCCVCVEAKEVPALLVGHLSIMAVQSVYDTSMPRPNRKMVRGEILPSAW
ILQPVTMEGKEITRVIYLAQVELGAPGFPPHLLSSFIKQQPLVVARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 220)

RVRPLSKRETKEGGRIIVEVDGKVAKVRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGELLWSWR---SETKLKPGKLS
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--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVELDGKVAKIRNLKVDNRLDSFGDSREKIMAFG
FDYCYWSVNPDDPQYASQDVVFQDLGMEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREEDYASPPSSCRIKV
SFLEIYNERVRDLLKQSVQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSSLSLNSSA-SNGGDSGIPSSTSGTSSG
GGPFRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELKEEIERLKAMLLSFELRNF-SSLNDEKDEDLKELVFQNELK
INQMTKDWTQKWNDWQALLEHYSVDIDRRKAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRSDSDQEQDIVLQGQWIERDHCTITSACGVVILRPARGARCTVNGREITASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5682)

GKAQKFRFNHPAEAAVLRRR-RQVGEAVGGS--GSLEWLDLDGDVTASRLG
LYPLLWK-ERRVLEEQCDEDHQPPRDGETSHKAQIQ--QQQCYVNDLRQEILAGQIRAEK
ELEFDQACISQQIKENQQWLLREETWLASLQQQQ-KD---NHVAEK--------EVEASV
APDVWLHTHPENQPSPLVQSQ-KRVVQLQLLQRHAVRAAERNARRKSVS--FQLERIIKK
QRLLEAQKRLEQLRALCWLQDDSTQKSPYWLPSPDA--MLPVSR-CRGRSTNCSSLSR--
RRLC---SQRSPQLHS-------------VFPNLDPSTMSSPVPDPTH----QISEKTPS
EEYMPRAAAYPPRTGRIRKNSL-RSSGPGKPCAGRGALASRGASAPDTYLTVSPES----
-IDIQEMDRVGKQPHWMVSQSLASRSQSANKLKPRDE-AKTLTPTTQIRRAKGLAGP---
-GHIQAGWREEG-NLETHKAA------KGATCSS---------LYPQGPKQTAVHGKAAK
TCW--ARYKPPPSSKASKRHQR--VLAARVRDFAKKSSHLPHGSPLKRQHSAGDLDTMAS
LRDSSPVVFCVRKKEDDLSDTDSNYSEDSLSCVYAKA-PKEPLKPEDPQGKKWNLPEPEN
SESDDSQISEDSLTEKEYQSPNKSPGGSHLT-NNG----QPRVRTRTSVRGFTV-PSDSV
LLAQAHRS--CDSLIDAGG--DLEEDQQEEPVFGSAGEIPTETFWRPQNYSLPIVDQ--E
AMCRLDSIDHRVG-GRLDAILPISSSFYLDASFHP------------------HYEPSES
EVEASCSERANPPQD-MQLSRDS---PLMSMDSWFSCDSKVNPSSPPGIVGSLCPSPDVQ
EFQSCDEERTGYWLNIKELKPSSIQTVL-SYSSKLPRGSTELPCSVRDE------D----
-----------TTS-ASDTSKLSLWGTQSCL---QRG-----ADGTS--QGRGIPDTAQQ
GSSEVSHSSSVSGVPTASATSF---TDVGSGQERDW------AALQQKYLLELSHPGLEA
IEEARP-----AFLCLEEDS--GSLTQASGKGGDTVLPIGPRVSGSLDFNNFPICLSKIR
RVRAEKEQDSLSAKLEGTSDFFSTSEKEMSYNETYS----ADLESLA-SGSMK--AQIFS
EENEIPNSMI-----ESREVKQNNLQE-CFQGS-RKPELKTSSDEYFFQKSTCHSTVT-I
ATKANHPPQGWAPLRKNSVIQPRQLSPN--SH-YPLQEEKADCQEGTR-EVVERHTNVS-
--VAFPSGPELCLHSAPWTPFPSS-LQPPALETFYVTKSRDALTETALEIPACREARVPS
PPAREAWGFGP-HLVLQNAYLKNNLPVLSQNQNSRIASSQ-WVTA---ERPVDLNTKEVV
RELGKCSGNIK-E-----ESH----------------------NSVYFFVAQNRPFLPSA
STKVCEFENQVGILNIKHGL-EALEG---EE-A--------------ASSDSLES-----
-------------GKPLLLICESEASGEEEQ----------------------------G
QSTVLR-PIRACLEKDMP--GETA----VSLESRSVHHRVSSPVIVAEDES--PMW----
DGKNETGLLGKALHPQDSSEEFKLPGTES-------THER--FQLVTCSR-ERNP--SEC
K-------E----MLNP--KEEPSGKKQNKRVN--GADEMARLIRSVMQ--LENGILEIE
SKQVKQLHASHTPGINK-FVFQDQ-KN-QKTDHVLR---TASSGHCLSFKGQPSSPKQTD
DVIFR--GGKTREM--EVNSSTG-NDPQVQKITP----SPFVSRECVRESRSVRGQTH--
SSKLDRSTKDVC--DS--------------LGTCTTHRE-----SPNTSLHPRR------
------------MKSLARALPLQPSPVSSSENDS-EWVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQTAEHISSS--------------MRKEPKAQGRVE-MAMQ
GGGSLQEEENETVSLTQKLCSLSQ-LYMDTFFSQETVCPLSSQTDPS-TAPP-QDL-ENT
LPLISPGLPISCLHDCD-AVGISSVD---FVLDPTMLKILNSP-LVTGVEL-QDQSGETR
SHSPQG-NG------------------------------------GGSSVAYAAPCESLI
SM-------ALGSHCQSGAPES------TEARISARTSL-QDQGGDLRIASMDLSTREGF
ASEAEVAVPKKTR-ASSLSRISSQLEKRVSFSLEDDDHQSTE-ARLK---AAEEAEAL--
--RH----------------SSSTSLAPVSLP----------------------------
-RVPTPEARLLE-PSVYASMCL-----AILEE----------IRQAKAQGKQLNDLVSGE
TVFPYRETLLELECSSRAAGRPQCTQMD-----------HSVSDGTRSEGKAQGSHGASL
SAEPGRL--SVDKRK--VQA--------TPL-SADSFQPPPTTEIDRE------------
-PRHPMQALSYGAS--ALGRRHSTGEL-GHFLGACEQVSCPSGSFEIIEK--EATRTSSS
AVPLALDSLLSSAAVEG--DRKAISE-----------------------------EV---
----------------------------------VAALSSQAPCDDLGVILR-----GRS
KP-AAWETAEGIPPGSRDSSPEHQEP--RTLEATYG-----------GGLDDFLLTAEG-
KE----------TAQLESQSVICDAQNSTSLS-SKQDHVQSLEASIGLEEGR-ARLKQGT
VLPETMRRVEL-----GAPAQEHVKWKGSIVSGLTEA-CG--------------------
AGSKHPR--PT------------------------SFPDQRPSPDPGGGREE-TPCRCRR
ETLDCPVFSGSIEGRRTLSPARGK-EESRISCCQLCNSHRV-ATC--SSCSSTLLRCRDG
DLGKETFMTSPHTVYPACVVASRACEMEEREESSSREPDMLLAHDR----EPQNMNMEFR
PTESSTLEPSSVDAVLFPTQGCNSHSA-PDVK-TGFLSHSAADRSSRSLEVPEKTVT---
---EKKAS--TELEVAPFPTGRYSEPLRKFQDSSVGCQNAQVSQ-TKAEPP--ATTRGPH
TLNLSERSAESGSVVE-SQHGCFKNT-ITCLSENPRLATESRDHNC-LDTQAKFVARLKY
TCSP--QGD-CPWEEEEQQRDQDS-GGGEDPAQGRK-----TPPSKE-GGLDGCRIINAG
KE-----------------EVAVAKP-----FSLGFEDPAGVSSGQSEVPQPAAQRPG-Q
---------P-HHRCSRPVIAVFSGLEHS-KSSPRPYFSVVSSSRSLQELNLS-AKTTSP
ADEDM-QGPNRLWNPHLRGFSMGKSMV------RTCLKTEDCHEKPSSNLD----DCTAD
HRPLKPAIPPY---PTYSTHSC-------MPTP---TLVTSWMAGALD--QAQQ-GKPEQ
LGIQVRPENLFSQ-VDKGMLHFGSRDINPYVPPRHPEGPVCIGWKQYVFGSAVGVSCNQE
PQGMMPSNESQCPG--TDNGLEDQNSPFHSHLHTCASARDLTSTCSSIATAQASN-AW--
---GSSLVLGGPHVLTGPEEAAPTVG-PDKRPCSP---GGAG-CLRGESHL--AEGSAAG
PVDEVMPPCLSETDCPVGQ-VRMNTFEQGTQTLG-CR-------LHRSCTDVSSAQLKDN
MASAP-DLASWASMHSLSLHLSQLLHSTSELLGSLSQPGVAKKEQNTK--KDTLDEAPQ-
-ALMMDGYTQTTVDEASQTDLASP-----------LCHQ-ASEAKPQENNV-ILEVLSS-
---GISTMS----------QAKGDVSGAFQKREA-EETAWK-MAQ-----FPDLQ-----
-QASTHCRSQSPLTC-SAPLRFQKDPLV--QALPSVIPPVPDTF-LPPISPLEESHCMAV
SSSSL----GTSHSPVLFHHA-SDFIREP--GMQKKL-GPTSALLVDRASSPILTLSASA
LELDL-PRGSLIPSAPSA----HPLDGHQKLY-SS---PDPPP-A--TLEPLMDNYPQTI
EESD---------------KGLS----ERS-----NGRCFLELCSPHSPRQ---------
-----------SPELQVGLVGQPPQHLEPSTVIEDPS-------------------RLLP
PPPPRR----SRRPADSLVPEEVVS-PEHGPLSSRGP---SRWQSRTENGGESSVSPVEP
Q-PTLDVSS-SWGG--L--------RHLSL--CPESELTG-----------TAKL-QGSA
LSPSQACKPEGLRRP---SSQMCMAPEPQHHGLRDLPVHNKFSNWCGVQDGSSEGLGVTK
-ELGTSCDASL-GEQ-GRGPLQP---------PKGQSQDPEWSQS------KQIPLQVGA
QNVSLSMELTEAKLHRGFGEADALLQVLQSGTGEALAPVEPVPSTLE--EIYARK-----
----------KTTIETLRRERAERLENFRRTRSLSPQKQVSLLPSRDVPSRDLDLPSRRR
EYLQQLRKDVVETTRSPESASR-PAHPPSDIELMLRDYQRAREEAKVEIARARDRLRERA
EQEKLRIRQGIRS--WLMLIWPSQEEEKLHTLANSSSLCTS-SNGSLSSGITSGYNSSPA
-LPSQLQSSEGEG-H------------------MNLPDS--KDTWIGDGQGRLAVR----
-----------N-----SHLASLGSC-CCCS--------PSSLSSLGTSL---SS-SYQD
LAKHIVDTSMADVSNCSSSSRHSF--------DQTSGEEQAV---------QLYFKVFS-
-STRHGFLG--AGVVFQPLSHVWAAVSDPTLWPLYHKPIQT

PF01852 // ENSGT00890000139327_7_Domain_2 (5682, 5806)

ARLHHRVTNSINLVYLVCN
ASLCALKQPRDFCCVCVEAKE------GQLSIVAVQSVYDTSMPRPNRKMVRGEILPSAW
ILQPATMEGKEITKVIYLAQVELGAPGLPPQLLSTFIKQQPLVIARLASFLGS

--MANVRVAL

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 422)

RVRPLSKREAKDGGRIIVEVDGRVATIRNLKVDDRPDGFGDSREKVVTFG
FDYCYWSVNPEDPRYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SMGLTP-RICE-----------------------------GLFSREEDHPSLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSAA-SDGGDSGIPSSSSRTSSG
GRPSRKQSYIPYRDSVLTWLLKDSLGGNSKTIMVAS-------YSETMSTLRYASNA-KN
I

ENSGT00890000139327_7_Linker_0_1 (422, 559)

INKPRVNEVRP---------------------SSRNF-SSPNDEKDENLKELVLQNELK
IDQLTKDWTQKWSDWKALMEYYSVDINRRRAGLVIDSSLPHLMALEDDVLSTSVVLYHL-
------------------

PF00498 // ENSGT00890000139327_7_Domain_1 (559, 610)

-KGQWIERDHCTITSACGVVVLRPTPGARCTVNGREVTASCR
LTQGAVITLGKARKFRFNHPAEAAVLRRR-RQVGEAVGGN--GSLEWLDLDGDVTASRMG
LYPLLWK-ERGVLGEQGEEDHPQPGNGATSHGAQIQ--QQQCYAEDLRQHILAGSIRAEQ
ELELDQAVLNQQIKDNQQWLLREETWLASLQQQQ----QQDCVAEK--------ELEASV
APDAWLQTDGEAQPPPLFQSQ-KRAAQLQLLRRHALRTAERNVWRKTAT--FQLERTIEK
QRLLEAQRSLDQLKALCWLQDDSTQQPPDQV---------PGPR-RRSRAAGCSSLSL--
QR----------------------------------------------------------
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--MANVKVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 395)

RVRPLSKRECAEGGRVIVEVDDKVTTVRNVKVDSRLDGTWDSREKTAAFS
FDYCYWSVDPEDPKYASQEMVFQDLGTSVLSGAFRGYNICLFAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFSRKDDYSDQTASCRVKV
SFLEIYNERVRDLLKQSDHKKPYTLRVREHPETGPYVQGLSQHLVTDYKQVVELLEEGIA
K--RITAATHIHNASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQIFSSCQSINTLT-SEGESSHMDSPSTG---S
VSGSRRPAYIPYRDSILTWLLKDSLGGNSKTIMIASEFDSC-------------------
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--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKREIKEGGRIIVEVDDKVTKIRNVKVCSRPESFGDSREKVVAFG
FDYCYWSVNPEDPQYASQEVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SAGLTP-RICE-----------------------------GLFIREDDYASLPSSCSIKV
SFLEIYNERVRDLLKRSSQNKSYSLKVREHPEMGPYVQGLSQHVVTDYQQVIRLLEEGIA
N--RITAATHVHEASSRSHAIFTVHYTQATLQNSLPSETISKINLVDLAGSERADPSYCK
NRITEGANINKSLVTLGIVISTL-AQNSQVFSSYQSLSAA--SSGGDSGVPSTASGTSSG
GGPVRRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPQVNEDANVKLIQDLREEIDRLKAMLLRFELI------------------------
-DHLTQDRMRKWNDWQILMEHYGVDINRRRAGVVIDSSLPHLMAVEDDVLSTSVVIYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVILQPTQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5671)

GKAQKFRFNHPAEAALLRHHRLQVGEALGSS--GSLEWLNLDGDVTASRLG
LCPVLWK-ERKVLQEGCDKNQQTSRNGKISHRAQTE--QQQCYVEDLRQQAIEGQSRVQK
EPELDQTHNSQKIKDNQQWLLRGETWLASLQETQQ-E--DDSGKEK--------ELAAFV
APDAWLP---QILPSALVQSQ-KRVVQLQRLRRRTSQASVWNIRQKKVS--FQLERIIKK
WRLLETQKRLEQLRAFYWLQDDGASKAPSCVSSSNT--SGPGSQ-RRSRWTACSSLSL--
QRLC---SQRLS-------------QLHSAFMNWNPSTMSPPVPDLTH----QIPKKALS
ADSVPQVTAYPPRTGCLGRNSL-HPSGWRKLYPARGASTRRRVSTQGTCLTVSHKS----
-VNSQETETLGKQPCQMSSQGLV-----TKKLKPRDG-SRTT--ATQTRRAKGLVVS---
-GNTQTEWQKEG-SCGTYKPH------KETTSHS---------TCLSGSEQAAGHGKVVK
TFQ--AESKPSPPSRTLKKHQR--VLPARGRDVAKKFSHLPHGSPLKRQPSTGNPDTLAS
FTDSRPMMDCVRENDNDLYDTDSSYSVDSLSYVYAKVP-KELQKPEDLQEK-WDLPDQEN
FQNDNSQISEDSLAEKGYQSPPENSGGEYSIMVPG----QSRARNSFSIRHFPK-PSDSC
LCVQAHRSFSLDSLIDAE---ELKEDRQEELFLGSADEMPTETFWHLQKATLAAVDQ--E
ATCRPSPVNHRTG-VRPNAFQPKSNSFYLDPHFQP------------------HCES-ES
EMAANYSEQANCLQG-MQLARES---PLVSVDSWFSCDSKVNLSSPSVTVQSLCPSPDVH
EIQPHD-EMPRYWLNIEEVKPPGT--VL-PHSSKLSQGSAEPPCS-SDL------Y----
-----------ANS-ASDTSKPSVCGSQRLL---QPG-----ADGAF--QGKEILDMIYQ
GISEESHNFDMSSVLAPSATSL---THVGTIHEEDW------AALQQKYLLELSNSVLEA
VGEPRP-----AFSFLEEDS--SSLTEASEK-VDTHLPVGPGVSKNLDFSYFPVHLSKIR
HLRAKKDRDNLSANLESSSDLFSTIE-KVSYNGAYS----ADLESLT-SGSVN--AQSCT
EGHKISNYVT-----EAWEVKQASLEG-CLQGS-RNSGLTTSSGQYFFQKKAYHNHDT-L
ATKADQCPQDGALLRKNTAVPSRLLSYH--SHPHPLLEEKAASQQQAK-EAGGTHTDTS-
--CTSPSGPELFLHSAPWNPFPSS-LQPPPLETFYVTKSRDALTETALEIPACREAWIPS
PPPREAWGFGHSYPVLQKAHQKNNLPNLSCSQNSKIDSSH-QVTTKTTKCSTNLNTGEVT
AELEKCTRKMSEE-----GNL----------------------DSAYCFVAHNKHHLPST
SFKVCECGNELGIFNKKYSLSVHKEG---EG-AS-A------WHHCSVAFDGTES-----
-------------K-TVLFICDSKASE---EEQ-------SLLPPQEQACGAH-SQPSGT
RSDFIGKITSLDLEKVIP--EETA----VSLKSRSLHCRVSSPVIMARSGNLTHRW----
EERNETVLFRE-VISKDIQEESSLPGTQY-------TRER--CHLVMCPQ-ERKP--IEC
KAHGQ-LQE----IK-S--KEEPLGEKQNMRVN--NADEMARLIRSVMQ--LETGILEIE
SKQNKQLQA--SQTTSTEFMLQAL-QDQERADHALI---PGSSGKHLFFDNQLSFPVQTE
DDILG--DSEAREM--EGNNAVSNNTQ-TLKSIG----SSFRSGGYAHKKQSKSEHYHP-
PPGIEGLAQDTC--AF--------------CGKSTTLRE-----PSNISFHSRR------
------------MKVLARALPLQPSVESSPEEED-ELLKA-----S--AD--FQDYAWTL
GNLEEPETM-----GSFQESQIVELPSDS--------------GLQDIKAHGRVEGLAVG
KGGNLQEE-N-MVSSTQKLPAPSH-QCKGTFSSQETVSPFHSQTGFS-AALPYAEP-SGT
PPLQSPSLPRRCLHAS-DTKGISSFE---YMLEPTMLKINRSS-LTTGVGH-QDYCGEIR
SSSPQR-SVT-----------------------------------RDASTAHTAWCGAVT
PM-------VMRADHQSVTPES--ILLETEDWITVSTSLQEDQRGDFRITSTGLTTQEGL
GSEYEATVQKEIKT-SSLDGVSRQTEKRVSFLLKEDSEHGKE-EMQK---AEKSE--DQ-
--QP----------------ASSACLTPLSLL----------------------------
-RAPDPEPLPLPDSSIHASICL-----AILAE----------IRQAKAQRKHLNDFAAEE
TVLPCETSQ--EECFSEAAVRP-GEKMV-----------KLGCDSTRTGDKAQGLHVASS
FAM-TDL--LAAERKAQP-M--------PPS--AGGFQHLPNPETDRG------------
-PGHHLLASTPIVP--NLEERPCTGEP-SGVSR-------WSDSSGVIEKKKETSRTLSS
VDPLAPDRLLSTSAVEQ--DGRVGS-----------------------------EK----
----------------------------------VSVLPSQNSCDDPGRIMC-----GQS
QL-AAWKTAAGICFGSQDSIPEYQEP--RSLDGTCG-----------GGSGKLLVTTQE-
RK----------AGNSECQSVICSVGNSAGLSGSKQDHVQCSDASTGLEEMK-ASPKSYA
VHPGAPRNVEA-----EAHMWHPVKWKNV-DSGLAEV-HG--------------------
ADSKNPV----------------------------SLLDQRPILHLSRVRED-APGLCPK
---ECLVFEGSTGGSRPPGLSYEEEENRTIPCPQLTGSQPT-AVHARCSHSSTLPCYRDG
FLRKETPQAAPHPVHSHFIVPSRACEVDRTVESFSKDSQVFLAHDL----EHKHVHVEFG
PIDSSIPNPSTAAAVSSRAQSCYPIPT-SEVK-ANCLTFAVAGGK-SVEGSEKKTSG---
--KKASTA--PQDAYPTSPAGSHSESLRT--EDNSVGENIQASQ-ANPEPA--VVIQGPH
TLSLNEGSVDSELVMAA-QYEHLGNI-TRRCSEKTQPSTEVRGHSC-LGSQANFIDRLKH
TCHP--QTE-TSWEEEEQQRDQAL-GDGKDHAQVRN-----LASSNE-GGFDGSHTRDSE
KE-----------------EVVVAKSPVSQTFFSDLEDPASLPLGQTEASQPDAQTPD-Q
LFSGREQLTF-RHRHTLPVIAVFSGPKLA-RYSPRPHFSVVSSSQSIHELNMR-VEAPSP
ADEDA-QAPKRLWSPHLRACSSEKPMS------T-SPETQDCNLKAPCDVN----NSPID
HRPLKPVIPPY---PTSSTVSC-------MPTP---DFMTDWIPGTLE--QAHQ-GKTDK
LNVQGMPETWHSQ-VDKEVLHFGSSDINPYVLPWCPQEPMDIGWKQYVFGSVADVSCSQK
PQSLIPSNMTQCSR--MNNALDDKKSPFHSHLRTYTQTRDLPNVCNRIENDQSSNEGWEM
QS--PSLAVEKPHILIGSEGVAPTWD-PDKRPPFRGSSEEIG-CLRSELSL--AGGSVPA
PVDEIVLLCPSETACEVGQ-ARMNTFEQGTQTLG-SR-------LHLSCTDVSA-QSDSR
TMSDF-EMASWTSMHNLSLHLSQLLHSTSELLGSLSQPNVIPKKQSIQ--NDSPDEAPQ-
-TLMMDGSTQTSEDEGIQTDLALS----------PLSFK-APEVKPQEVNV-ILEVMDS-
---GITTMF----------QEKEDVPGVFPKRGT-EE-----AAE-----APDLH-----
-EGNTHYNLQSPSMPS-PCLRFQKAHLG--QNLTFESPPASTNGSSPPSLQPEASS-MVV
NSPSI----LH---HSELLLGAPELTQEP--DTQKKP-GPSSALLVDRASSPILTFSAST
QDLSNT-LASLTLSVPSA----HSLGDVQETA-IS---PDLAV---DNPRPLMDNSQA-T
SGFSVS---QRAGSLEREGKSPL----GKS-----SEGLVLDSSSPCSPQR---------
-----------SSSLQVSFLGQAPQQLQPMNTTGDQS-------------------SLPS
PPPRHR----SLKLDDSFVPKKVAS-IEHGPQSSRRP---SQCQDRTANEDENSVFMVEP
Q-LSLDLSS-PWRD--L--------QPLSP--CPISD--------------TAGL-PSPA
EEPPQACQFEGLLCP---GSHVSVAPDLQHHSLRDLPVHNKFDNWYGVQDGSCGGLPVSE
-NLGIGCDFHS-VDQ-TQRSLKP---------SDNYNQEPEWPQF------ERVPLQVGV
QKPSLSVELTEAKLHRGFGETDALLKVLQNGTGEVYAPQEPAMSSCG--EFYTRQ-----
----------KKTIETLRRERAEGLPNFRRTRSLSPQKHLSFLLSKDLPTWEHDLPSRRQ
GYLQQLRKDVVETTRIPEPAPR-SAHPPSDIELMLRDYHQAREEAKVEIAKAQDRLRQRT
EQEKLKIRQQIISQLLK-------EEEKLQGLANSSSLCTS-SNGSLSSGITSGYNSSTA
-FSGHLPSLEVKE-D------------------SRVPDF--RDTWIGDWRGRSTVRNSQL
YLTGSSWKSLAH-----RCRAPLGS--GSCS--------PSSLSSLGTCF---SS-LYQD
LAKHIVNTSMADVMAACSDNLYNLFSRQATAGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--AGVVLQPLSRVWAAVSDPT

PF01852 // ENSGT00890000139327_7_Domain_2 (5671, 5806)

LWPLYHKPIQTARLHQRVSNSISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPNRKMVRGEILPSAW
VLQPVIMEGKEITRVVFLAQVELGAPGLPPHLLNSFIKQQPLVVAKLATFLGS

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 323)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRTDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSAVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENSLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-GIF---------------------------------
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--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSVILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLSDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGR--GSLEWLDLDGDLAASRLG
LSPLLWK-ERRALEEQCDEDHQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIRAEK
ELEFDQAWISQQIKENQQCLLREETWLASLQQQQ-QE---DQVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVHLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDA--TVPRPR-CRSKLTSCSSLSP--
QRLC---SKHMPQLHS-------------IFLSWDPSTTLPPRPDPTH----QTSEKTSS
EEHLPQAASYPARTGCLRKNGL-HSSGHGQPCTARAALARKGASAPDACLTISPNS----
-VGIQEMEMGVKQPHQMVSQGLASLRKSANKLKPRHE-PKIFTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHKAA------KGASCNS---------LYPHGPRQTAGHGKAVK
TFW--TEYKPPSPSRTSKRHQR--VLATRVRNITKKSSHLPLGSPLKRQQNTRDPDTMVP
PTDFSPVMDHSREKNNDLSDTDSNYSVDSLSCVYAKA-LIEPLKPE---ERKWDFPEPEN
SESDDSQLSEDSLAEKRYQSPKNRLGGNRPTNNRG----QPRTRTRASVRGFTA-ASDSD
LLAQTHRSFSLDSLIDAEE--ELGEDQQEEPFLGSADEIPTETFWHLEDSSLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQHHCEQAES
QVEPSYSEQADSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFHPCKGERPGYWPNTEELKPSDAETVL-PYSSKLHQGSTELLCSARDE------H----
-----------TAS-AADTSRLSLWGIQRLI---QPG-----ADGTF--QGRCVPDMTQQ
GSSEASHNSSVSKVLAASATTL---THVGSTHERDW------SALQQKYLLELSCPVLEA
IGAPKP-----AYPYLEEDS--GSLAQASSKGGDTLLPVGPRVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETYS----ADLESLSASRSTN--AQVFA
AENAMPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEDFFQKNACHSNVT-T
ATKADHWSQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINVS-
--FALPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQ-QVTA---EIPVDLNTREVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVVILNKRHSF-PALEG---GE-VT-A------QSCCSASSDSTES-----
-------------GKSL-LFRESEAQEEEEL----------------------------D
QNTVLRQTITVSLEKDMP--GESA----VSLKSRSVDRRVSSPVMVAQDGGPTPKW----
EGKNETGLLEKGLRPKDSSEEFKLPGTKP-------AYER--FQLVACPQ-ERNP--SEC
K-----SQE----MLNP--NREPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGTDKELVFQDQ-KEQEKTDHAFR---PDSSGNPLPSKDQPSSPRQTD
DTVFR--DSEAGAM--EVNS-TG-NHPQVQKITP----NPFRSREGVRESEPVREHTH--
PAGSDRTARDIC--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALARALPLQPRLERSSKNNG-QFVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQVAEHVSSS--------------NQEEPKAQGKVEEMPMQ
RGGSLQEENK----VTQKFPSLSQ-LCRDTFFRQETVSPLLSRTEFC-TAPLHQDL-SNT
LPLNSPRWPRTCLHVPV-ALGISSLD---CVLDLTMLKIHNSP-LVTGVEH-QDQSTETR
SHSPEG-NVR-----------------------------------GRSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--IPLGTEDRISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIR-VSSLNKVSSQPEKRVSFSLEEDNDQASK-PRQK---AEKETEDV--
--GL----------------TSGVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDHASMCL-----AILEE----------IRQATAQRKQLHDLVARG
TVLSYCETLLEPECSSRVAGRPQCKQID-----------QSSSDQTRNEGEAPGFHVASL
SAEAGQIDLLPDERK--VQA--------TSL-SADSFQSLPNTETDRE------------
-PWDPVQAFSHVAP--AQDRKHRTGEL-RQFAGASEPFICHSSSSEIIEKKKDATRTPSS
ADPLAPDSLRSSAPVEE--VRRVVSK-----------------------------KV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPPGSQDSSPEHQEP--RTLDTTYG-----------EVSDNLLVTAQG-
EK----------TAHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGR-ASPKQDT
ILPGALTRVAL-----EAPTQQCVQCKESVGSGLTEV-CR--------------------
AGSKHSR--PI------------------------PLPDQRPSANPEGIGEE-APCRHPR
EALDGPVFSRNPEGSRTLSPSRGK-ESRTLPCRQPCSSQPV-ATHAYSSHSSTLLCFRDG
DLGKEPFKAAPHTVHPPCVVPSRAYEMDETGEISSRGPDVHLTHGL----EPKDVNREFR
LTESSTCEPSTVAAVLSRAQGCRSPSA-PDVR-TGSFSHSATDGSVGLIGVPEKKVA---
---EKQAS--TELEAASFPACMYSEPLRHFRDSSVGDQNAQVCQ-TNPEPP--ATTQGPH
TPDLSEGSAESKLVAE-PQHECLENT-TRCFLEKPQFSTELRDHNR-LDSQAKFVARLKH
TCSP--QED-SPWQEEEQHRDQAS-GGGEGFAQGVN-----PLP-DE-DGLDGCQILDAG
RE-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETSQPAAQRTG-H
LYTGREQPA-------LPVTTIFSGPKHS-RSSPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNPHLRGYSSGKSVA------RTSLQAEDSNQKASSCLD----DGTTD
HRHLKPATPPY---PMPSTLSH-------MPTP---DFTTSWMSGTLE--QAQQ-GKREK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRPEEPARISWKQYMSGSAVDVSCSQK
PQGLTLSNVARCSS--MDNGLEDQNSPFHSHLSTYANICDLSTTHSSTENAQGSNEAWEV
FRGSSSIALGDPHIPTSPEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPPL--AEGSAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFEQGTQTLG-NR-------RHWSSTDISFAQPEAS
AVSAF-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLTLP----------TLCLQ-TSEAEPQGANV-ILEGLGS-
---DTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQSPSIP-SSHLRFQKAPVG--QHLPSVSPLVSDAF-LPPSSQPEESHCLVV
SSPSP----SSPHSPGLFPST-FEYPGDS--RVQKKL-GPTSALLVDRASSPILTLSAST
QEPGL-SPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVD-A--PRTP-MDNYSQTT
DELGGS---QRG-------RSSL----QRS-----NGRSFLELHSPHSPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTIGVQS-------------------RLLP
PPLRHR----SQRLGNSFVPEKVAS-PEHCPLSGREP---SQWQSRTENGGESSASPGEP
Q-CTLDRPS-SWGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEELLCF---SCQMCMAPEHQHHSLRDLPVHNKFSNWCGVQKGSPGVLDMTE
EELGASGDLSS-EKQ-EQSPPQP---------PNDHSQDSEWSKR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGETDALLQVLHSGTGEALAADEPVTPTWK--ELYARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERT
EQEKLRIHQQIIS--QLL-----KEEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQFPENMG-H------------------RNLPDS--RDVWIGDERGGHSAVR---
-------KNSAY-----SRRASLGS--CCCS--------PSSLSSLGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSRVWAAVSDPTLWPLYYKPIQTARLHQRVTDSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

------------MTEGESEIKEGGKIIVEVNGKVAKIRNLKVDGRPNGFG

PF00225 // ENSGT00890000139327_7_Domain_0 (51, 421)

DSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRKENCAPLPASCSIKV
SFLEIYNERVRDLLKQSDQKKTYNLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAFLENNLPSEIASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFNNCQSLNSAA-RDGGDSGLPSSPSGTSSG
VGPSRRQSYIPYRDSVLTWLLKDSLGGNSRTIMVATISPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIGRLKAMLLSFELRNF-HSLNEGKDENLKELILQNELK
TDQLSKDWSRKWNEWQALMEHYRVDINKRQAGLVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVILRPARGARCTVNGREVTSSCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5610)

GKAQKFRFNHPAEAAVLRQRR-QVGEALGGS--GSLEWLDLGGDVAASQMC
LCPLLWK-ERRALGEQSNKDHWPLRAGETPCGTQIPQQQQQHLVGDVRQQILVGQIRAKQ
EAEPKQLHTGLRVEDDQG--LLQGAKSKKPGQQP--Q--QDHAAEK--------ELEAAV
PSHSWCQTDPKTQPYPQVRSQ-SNVVHPQFLRR-----HEWNIRQRRAS--FKLERVIKK
QRLLEAHRGPEQLRALCWLQDDRLRRTPFPALCPGA--LIPGPH-RRSRLTSCSSLRL--
RRPC---SRHSA-------------QLRSVFVNRDPSTTLPPMPDPTE----QLSEE---
--YLPLAASYPPRIGHLIQHAL-RSSGEGQFGTARKALAWKGASHLGTCLTESSES----
-ASVQEVERMGKQPHQMVAQSLVSLGQSAHKSLPLPL------------RPGGLRPCASR
VVNKREPW--------AHEVV------EGASCSS---------SHLHGS----KHGKAAK
TFW--AGFIPLSPSEASKRQQR--VLAARF----EKSSCLSHGSLLKRQHRVGDPD--TG
LTHSSPIVALAREK-GDVSDTNSGYSVGSLFCVCAQA-LPAPLELEETQRKERDLPEPDN
SESDDSQISEDSLAEKGPRNPRDSPGHSYLTSGCG----HSQARARASGRGFTT-SSGSR
PFTLAHRSVSLDSLIDAEE--EPGDHWQGKPFFGSTDEMPTETFWRLQSPILPAGGQ--E
AVCRLGSISHRRA-PRLDAILPVSSSFYLEPQAQQ------------------PCEQPEV
AVAGSPTEPATMLQD-VQPSRGS---PLVSMDSWFSCESKINPSSPQ---HSLCPSPDIQ
EVQCCGWERPGYWLNTEELKSPGTETIL-PFSSTLPPASTELPCSIRSV------Y----
-----------TGP-VSGS--VSLCDPCSLL---HPG-----AEGTF--QASGVPDTAQQ
GVSEAS-NSSVSSLLAASASSF---TYVGSACERDW------AALQQKYLLELSHPVLEA
TGAPRP-----VSPSLKENS--DFPIQASGRGGDTILPVGPGASSSPDFNNVPTHLSKIR
RLRAEKEQDSLNVKVEGTSDFFTTSEKEASHSGTYS----ADVESLT-SGPTN--AQVSA
AENKMAYPVT-----AVRGVKKSSLEE-SSQSS-KKPGLMTSSDECFILKKPCHHIVT-I
ATKDPHCPRGGAPLKKKRAGPERQLGQK--SH-RPPQEEKTDSQESSM-EAGGRHSRPS-
--CPFPSGPELYLHSAPWNPLPSS-LQPPPLETFYVTKSRDALTETALEIPACREARVPS
PPLREAWGFGHEHQVLQSVYVENKLPVQLQNQNSKIVSSQ-QVAA---ERPVDLNTKEVC
REEGKCFGKVKET------SH----------------------NSVYFFVTQNGHFFPST
SIKVCKFENQVGILN-RHSLTTLGQG---AK-AP-V------QSHCSVSSNSSGS-----
-------------GKPLLAS-ESETGEEEGQGQ-------NTVLTQAQAFDAKRHFPSRV
RSDFTCKSIYLAPDKDKP--QGAA----LPLKSRSVRCKVSSPETLALGESPAHKE----
ERRNETGLLGKAPHYRDGSEEFKLSQTES-------TYEQ--FQSVTCCQ-ERNL--SKC
KVPGK-VLK------AN--PKEPPGKTWGERVN--NADEMARLIRSVMQ--LENGISEIE
SKQGKQLHASHPPGVSKEFIFQYQ-QDQETADSVLR---TGSFGNHPPFKDQLASPKRTD
DVICR--ADEAGEV--EVNGSADPW---------------------GPGSRFVRGHT-Y-
LAVLDTPAKDSG--GY--------------LGVCTVCRE-----CTNASAHP-R------
------------MKASAGALPLQPRPKGASEEGK---VVS-----A--VC--LRRQPRSL
GSLEELETG-----DGVQESHPAKCIH----------------KQEEPAVRGRVEEMAAQ
RGSL--EERN-TVSATQRLPGLCH-HCVHTSFSHKT-GLLPSQADSC-MAP-HQDL-SHT
LPLNSTRLPRSNLSAP-NTLGISSVD---CVLDPTMLEMPTSP-LAAGVEQ-QDQIGVSG
RHSLQG-GSR-----------------------------------QCSSVAHSARPGSVP
SV-------AMGPHGQSSPPGS--IPLGAEGKRSASTGP-QDQGGHLRSSSMGPGSRVGS
PSRAKAAEPRGPDRAGALNGAFSLLERRVGSPLEEADNQGRE-VRQE---AE-----DL-
--SP----------------AGGAFSAPMSPP----------------------------
-VVPQSEPSAQ------PPTSL-----AVLEE----------TGQAKTQGKQLYDVVAGA
AVLPSSKTLLEPECSSRAPSRLQCPQMG-----------QSVANRTPNEAEAR-NHMASL
SVEPGHL--SVDKRTTVLQA--------IPP-SADRFHSLPSTDTDMG------------
-LQCPSRTCSHTDP--APGGSHGTGKP-ERFLGAGEQSVCHTSSSEITENSKEATGASPS
ADALVSDGLPSSAASRE--EDRRVMT----------------------------GEV---
----------------------------------VAASLSQAPFEDSGQIAQ-----GRE
VL-AA---AEGMLPGHQESSPAHQEP--GTLDCTWG-----------GGSDNFQAVAQR-
GR----------TTCFESHLVISVVQNSTSLSEPNQDQGQCLEASTSLEEGR-ASPKRGT
LLPGALRGFGP-----EAPSQPRVKQEGSVGFGPAEA-CR--------------------
ASMESPR--PA------------------------LLPDQS----PRGVREE-ALSRCPR
EDSGFGVSSWSPGGSKTLGLSQGQEESRSGPCWQPCSPQPV-VWGAHSSPPSTSLCYRDG
DLGRGASTAPLHPYH-PSRVPSRPWGMERR-EGLGGESGVLLAHGL----EPKGINVELG
PADSSTPEAS-ATGVLPLTGGCSSPSG-PDMK-TSPLSHSLTDGSSRSVGDPEKKAA---
---EKKVR--AELEAIPFPEGKCSETPGRVQDSSGGGQGAKGSQ-PKP-----AAAEGPH
TLNLSDRCVESELPEG-LQQGCLGND-IRCLSEEPQLPPGSRDHGG-LHPQAKLITELKY
ISRS--QVD-SLWEEEEQQRDQAT-GGREDPAGVRS-----PPHADE-GGSDSCQTRGPD
RE-----------------GRTVARSPVSKTILSSFGDSATVSLGQRRAHWPAAQGPG-Q
PPSGREQPAP-HHRASRPIIAVFSGRRHS-----RPQFSVVSSSRSLQELNLS-VEPPSP
TEEDI-AEPNRLWTSHPRGTSSGKSVV------RTSLNAEGCDQEGFPDLD----SIAAD
LRPLPPAPPPY---SATSGFLR-------MPTP---NLTSVHPSGALE--QAQS-GKPER
QGGQARPEQRHSTDVGGGALLLCPSDVNPCFLPWHPKGPARPGWRQHVFGSAVSVSRRPT
SQGPAPPNVAQ-SS--MDSRLEDQSSLFHSHLSTLASAQSLLNKRSSGGNARGSREAWEV
WG--SLPALRNPDILISSEEAAPLKG-PDERAQFRGTPGEVG-SLRREPPW--AEGSAAG
PVDEIMRLYPPEVGGPIAQ-SRMDTLEQGTQTLG-CG-------SHWSYSDFSSAQS---
------DLASWASMHNLSLHLSQLLHSTSELLGSLSQPSVAEKEWNAK--RDTPHEVPQ-
-TQMMDGSTQTTVDEGIQTDLASP----------PLHLQ-APEADPQKVNV-ILEGLGS-
---DLASMS----------QGKGRVPGTLQKREA-EETVWK-TAG-----PLDLQ-----
-GEDTLCRPQSAPVPS-FHFNFQKGPFE--QNLPSLSPQASPDALLPPSSQPEEPTCLAV
GRPCL----SAFSSPGPCTQA-AESVGEL--RVQKEQ-GSASTLLVDRASSPILTLSAST
PGSGIP-LSALSLSSPSA----LSLDSRQKLM-SS---PSLPL---PAPRPPVGNFSQTT
DEADGS---RRAGAPCGEGRSSL----EEG-----DCRPFLGVSSQGSPQQ---------
-----------STKLQVCFVQQPLQQCLPRATAGVQS-------------------RLSP
PPLGNR----SQRLADSFLPEDVAS-VECGPLSRRGP---GGWQSRAEKRGEHSASPVEL
R-PALDV------------------QRHSP--CPFSELTD-----------TPGL-QGCV
LGPPVACQPGGLLPP---GSQMHTAPEPQHHGLRDLPVHNKFSDLCGPQNNSPGGPGTMD
-SLGTRCDCSS-GEQ-SQRLPQA---------PEDQSRAPEWPQK------EQIPLKVGA
QNLSLSTELREAKLHHGFGEADALLQVLQSGTGEALTAEEEELY--------ARP-----
----------KHPAETLQRERSEELQNSRRTRSLSPKKQLTFA-------RDFDLPSRHR
EYLQQLRKDIVETTRSSGSASR-SSHPPSDIELMLQEYQRAREEAKVEIARARDRLRERT
EQEKLRIRQQIISQLLQ-------EEEKLHTLATSGSRCTS-SNGSLSSGVTSGYNSSPA
-LPSQLQSPDSVG-D------------------TNLPDS--RDSWIGEVRGRSSVRNNQL
NLASSAWKCLAY-----SRRAALGS--CCCS--------PSSLSSLGTSF---SS-SYKD
LAKHIVDLCMADVMAACSDNLNNLFSCRA

PF01852 // ENSGT00890000139327_7_Domain_2 (5610, 5806)

AAGWNHQGEEQE--------VQLY-YKMFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNSINLVYLVCN
TTVCALKQPRDFCCVCVEARE------GQLSVMAAQSVYDASMPRPSREMVRGEILPSAW
ILQPLTVEGKEITRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDTREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICVFAYGQTGSGKTYTMLGTPV
SI-IIR-YIPN-----------------------------GLFVREKDCASRPSSCRIKV
SFLEIYNERVRDLLKQSSQKKSYALRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RFVSIILLSSHS--FPVIFQQHYKDSVLFAFV--------SVFIDCFSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQFFIPYRDSVLTWLLKDSLGGNSKTIMIATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-TSLNDEKDENLKKLVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LSPLLWK-EGRVLEEQCDEDHQPPRDGETSRSAQIQ--QQQSYVEDLRQQILAEEIKAER
ELELDQACISQQIKENQQCLFREETWLASLQQQQQQQ--EDHVAEK--------ELEGSV
ALDAWLQTDHEIQPSPFVQSQ-KRVVQLQLLQRHTLRAAEQNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEHPYWVSSPDA--IVPEPR-CRSRSSSCSSLSL--
QRLC---SKHVPQLQS-------------VFLSWDPSTTLPPMPDPTH----QTSEKTSS
EEHLPQAASYPPRAGHLRKNGL-HSLGHGQHYTARAAKARKGASAPDTCLTMSPKS----
-IGIQEMQRVGKQPCQMMSQGLVSLRQSANKLKPRDE-PKILTSTTQNRRAKGLADP---
-SHTQSGWQKEG-NLGTHESA------MGASCSS---------PYPHGPKTTAGCGKAVK
TFW--IEYKPPSPSRASKRHQR--VLAARVRDITKKSSHLPLGSPLKRQQNARDPDTMAP
LTDFSPVEDHSREKDNDLSDTDSSYSVDSLSCVFAKA-LLEPLKPEDPQGRKWDFPEPEN
SESDDSQISEDSLAEKSTKSSKDRLLGSHPTNNHG----HPRIRTRAFVRDFTA-PSDSD
LLAQTHRSFSFDSLIDTEE--ELGEDQPEEAFPGSAYEIPTETFWHLENSNLPLMDQ--E
AICRLGPANYRTG-ARLDAVLPMSSSFYLDPQFQP------------------HHEQAES
QVEPSYSEQPNYLQG-VQLSRES---PLMSMDSWFSCASKINPSSPPGIVGSLCPSPDVQ
EFQPCDGERPGYWLNTEELELSGAETVL-PDSSKLHQGSTELLCSTRDE------H----
-----------TTS-ASDKSRLSLWGIRRLV---QPG-----ADGTF--QGRGIPDMTQQ
GSSEASHNSSVSNVLAASATTL---THVGSTHERGW------SALQQKYLLELSHPVLEA
IGEPRP-----AFPYLEEDS--SSLAQASSKEGDTLFPFGPRVSSNLDLNNFPLHLSRIR
RLRAEKEQDSLNAKLEGASDFFNTSEKVVSYDETYS----ADLESLAACESTD--AQVFA
TENMIPNSVA-----EACELKQNNLEE-CLQSC-RKPRLTTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPRQLSSN--SH-YSLEEEKIDCQESSK-EVVRRHINVS-
--FAFPSGPELYLHSAPWNPSSLS-LQPPPLETFYVTKSRDVLTETALEIPTCREVRVPS
PPPREGWGFGYNHQVLQNAYLKNNLPVLLQNQHSKIASSQ-QVTA---EIPVYLNTREVI
RESGKCPGNII-E-----ESR----------------------NSVYSSVTQNRHFFPST
STKVCEFENQVEILSKKHSF-LALKG---EE-AT-V------QSCCSASSDSTVS-----
-------------GKPLTLFCESEAGKEEEL----------------------------D
PNTVLRQTISVGHEKDMP--GESA----VSLKSRSVYHRVSSPVMVAQDESPTPKW----
EGKNETRLFVKALHPKDSSEEVKLPGTKP-------AYEK--FRLVTCPQ-ERNP--SEC
K-------K----MLNP--KGEPSVKKQNKRVN--NTDEMPRLIRSVMQ--LENGILEIE
SKQSKQFHASHTPGVNKEFVFQDQ-KEQEKTDHALR---PDSSGNALPSKDQLSSPRQTD
VTVIR--DSEAGEM--EVNN-AG-NHPQVQKTTV----NPLRSREGVQENEPVREHTH--
PAGSDRSSRDTC--AS--------------LGTHTTFRE-----FTNTFLHPER------
------------MKALARALPLQPRLERSSENDG-QLVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQIAEHIS-S--------------NQEEPKAQDKVEEMPMQ
RGGSLQEENK----VTQKLPSLSQ-LCRDTFFSHKTVSPFLSETEFS-TAPSHQDL-SNT
LPLNSPRLPRSCLHAPD-ALGISSLD---CVLDLTMSKTHNSP-LVTGVEH-QDQSAETK
SHSLEG-NVK-----------------------------------GGSSEAHTAWCGSVR
SM-------AVVSHSQSGIPES--VPLGTEDRISASSSP-QDQGRDLRITLMGFSTSKDF
ASEGKVAVQKEIG-VSSLNKVSRQPEKRVNFSLEEDNDQGSE-PRQK---AEKETEDL--
--RL----------------TSGVFLASASLP----------------------------
-RMPNPEPRPLE-PFDHASMCL-----AILEE----------IRQAKAQRKQLDDCVARG
IVLSYCETLLEPECSSSVAGRPQCKQID-----------QSSSDWTRNEGEVLGFHVASL
SAEQKLL--STDERK--DQG--------TSL-FADSFQPLPDTGTDRE------------
-PSHPVQAFSHAAP--ALDKKHCTGEL-RQFAGAGEQFLCHSSSSEIIEKKKDATRTLPS
ADPLAPDSLY-LAPVEG--VRRVVSK-----------------------------MV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QA-VPQETAEG--PGSQDSSPEHQEP--RTLDTTYG-----------EVSNNLLMTTQG-
EK----------TAHFESQSVICDVQKSTSPSGPKQDHLQCPEASTGFEEGR-ASPKQDT
LLPGALTRLEL-----EAPTQQCVKWKESVGSGLTEV-CR--------------------
TGSKQSR--LT------------------------PLPYQRSSPSPEGIGEG-APCRYPR
EALDCPVFSRNTEGSRTLSPSRGE-ESRTLPCQQPSSSQPV-TTHADSSHFSILLCYRGG
DLGKELFKVAPHSIHPPCVAPSRAFEMDERGEISSRGPDMPLTHGL----EPKDVNREFR
PTESNTCERSTVAAVLSRAQGCSSPSA-PDVR-TSSFSHSATDRSVGLIGVPEKNVA---
---EKLAS--TELETASFTAGMHAELLRQFRDSSLDDQNAQVLQ-TNPGPP--ATTQGPH
ALDLSEGSAESELVAE-PQHGCLENT-TRCLLEKPQFPTESRDNNC-LDFQTKFVAKLKH
TCSP--QDN-SPWEKEEQQRDQAS-GGADGFAQCVN-----PPPSDK-GGSAGRQILDAG
RE-----------------EVAVAKPLMSKILSEGFKDPATVLLRQNETPQPVAQRPG-H
LCTGREQPAP-NHRCSLPVIAVFSGPKHS-KSPPTPQFSVVSSSRSLQELNLSSVEPPSP
TEEDT-QGPNRLWNSHLRGYSSGKSVA------RTSLQAEDCNQKGSSHLD----DDTAD
HRPPKPATPPY---PMPSTLSC-------MPTP---DFVTSWMSGTLE--QAQQ-GKPEK
LGVQVRPENWCSQ-MDKGKLHFGSSDINPYALSQHPEEPAHIGWKPHVFGSVVNVSCSQK
PQGLTPSNVVQCSS--MDNGLEDQNSPFHSHLSTYANTQDLSSTHSSSENAQGSNEAWEI
FSGTSSTVLGNPHILTSPEAIAPTSG-HDRRPQFRGPSSEVD-CLRSKPPV--AEGGASG
PVDEIMLLYPSEAGCPVVQ-TRTNTFKQGTQTLS-SR-------RHWSSTDVSFTQPEAS
AVSAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDILDEAPK-
-ALMMDGSTQTTVDEGSQTDLASP----------SLCLQ-ASVAKPQEVNV-ILEGLGS-
---DISTMS----------QEKGDVPGVPQKREA-EETAWK-MAQ-----PPYHQ-----
-GESTPCKPQSPPIP-SSHLRFQKASLG--QHLPSVSPSVSDAF-LPHSSQPEESPCIVV
S---------PSHSPGLFPST-SEYPGHP--RVQKKL-GPPSALLVDRASSPILTLSAST
QDPGL-PLSFLTLSAPSA----HPVEDHQKLD-SS---PDPVG-A--PRTP-MDNYSQPT
SESGGS---QRG-------RSSL----QRN-----DRRTFLELDSLHGPQQ---------
-----------SPKFQVSFLGQPPQQLQPRTTIRVQS-------------------RLLP
PPLRQR----SQMLADSFVPEEVAS-PEHGPLSGREP---GQWQSMTENGGEGSASPVEL
Q-CTLDLSS-SWRG--L--------QHLSP--CPVSELT-------------AGL-RGSA
LGLPQACPPEGLLCQ---SCQMCMAPEPQHHSLRDLPVHNKFSNWCGVQKGSPSGLDLTE
-ELGASCDLNS-EKQ-EQSPPQP---------PNDHSQDPEWSQR------EQIPLQVGA
QNISLSVELTEAKLHHGFGEADALLQVLQSGTGEVLATDEPVISTWK--DLYVRK-----
----------KDAVETLRRERAKRLRNFSQTRSLSPQKQLSLLPSKDRLIRDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHPAFDIELMLRDYQQAREEAKLEIARAQDRLREQT
KQEKLRIHQQIIS--QLL-----REKEKLHTLANSSSLCTS-SSGSLSSGMTSGYNSSPA
-LSGQLQSPENVG-C------------------TNLPDS--RDSWIGDERGPSANSAYSE
LW---AMLGIVT-----CHRASLGS--CCCS--------PCNPSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTDSINLVYLVCD
TTLCALKQPRDFCCVCVEAKE------GHLSVIAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGREVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

------VVGVNVLGLFSRETKEGGRIIMEVDGKVAKIRNLKVDNRPDGFG

PF00225 // ENSGT00890000139327_7_Domain_0 (51, 421)

DSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREEDYAPLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYSLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQAFSSCQSLNSAA-SDGGDSGIPSSPSGTSSG
GGPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KH

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IVNKPRVNEDANIKLIRELREEIRRLKAMLLSFELRNF-SSLNEEKDENLKELVLQNELK
IDQLTKDWTRKWNEWKALLEHYRVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPAQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5671)

GKAQKFRFNHPAEAAVLRQR-RQVGEVVSGN--GSLEWLDLDGDVTASRLG
LCPLLWK-ERKVLEEQSDQDRQPLGAGEAPHRAPIQ--H-QHYVGDLRQRILAGQIRARQ
ELEFDQAHLSRQIKDNQQWLLIEEPRLAGLQQQQQQQ-QQDHIAEK--------ELEACV
RPGAWLQTDLETPPPPLVRSQ-KREVRLQLGRRNVLRAAQRDIRRRKAS--FQLERIIKK
QRLLEAQTGLEQPKTLCGLQDDHTQKPPYRLPGAGA--MVRESQ-HRSRLTDCRSLSL--
QRLC---SQYLP-------------RLHSIFLSRDPSTMVPPLPDPTD----QMSETIPS
EEYLPQAASYPPRTGHFSKNAL-CSSGKGHLCKARGALARKGASASGTCLTVSSES----
-ASIQEMESVGKQPCWMVSQSLASLDHSANKLKPKDE-PEALSPSTYTGRGRGLADS---
-DHTRSGWRKEG-NVGTHKTA------KGARCSS---------SHPCGPRQASGHGKAAK
TFW--VESKPPSSSKASKRQQR--VLVARARDIVRNSSCLPHGSSLRRQHSAGDPDSTSS
LTDCSPRVDLVREKDGDLSDADSSYSVDSLSYVYAKA-QMEPLKPEDLQGKEQDLPESEN
SESDDSQISEDSLAEKGYESPPDSSGSSYLTNHYG----HPRARAKVPVRGFTM-SSDGE
LFTQTCRSFSLDSLIDAKE--ELGEDQ-QEPFFSSADEMPAETFWHLQTSSLPIVDQ--E
AMCRLGPINHRTG-TRLDAILPMSSSFYLGPPPQP------------------HCEQPES
EVEVSSSEQANTLQG-LQLSRGS---PLLSMDSWFSCDSKINSSSPSGIVGSLCPSPDIQ
EFQPQGQERPGQWQNMEELKPSRAETLL-PYNSKVPQGGTELPCHIRGV------Y----
-----------TIP-ASDTSRLSFWGSYSLL---QPR-----VAGIF--RARGTPDTAQQ
GNSEASNTSSLSSVLAASAASL---TDVGSAPERDW------AALQQKYLLELSHPVLEA
VREPRP-----AFPSLEEDS--TSLTQASGKETDTVLPVGFGVSSSLHFSTFPLHFSKIR
HLRAEREQDSLSAEIEGTSDFLTTREKEVSHSGTYS----ADVESLT-SGTIN--APVFV
AENKVANSMT-----QAREDKQNSLEE-SSQSN-GKPGLMTSSDECFFLKSPCHSNVT-I
ATKENHGPRGWAPLRKNSAGQEGHLSHS--SY-LPLQEEKVNYQESSR-EVVGRHTSVS-
--F--ASGPEPYPHSAAWNPFLSS-LKPPPLETFYVTKSRDALTETALEIPACRESRVPS
PPPREAWGFGHDHQVLHNVYVKNNLPVLLQNHNSKIPSSQ-QVTA---GRPVHLNTKEVI
RKMGKCPGNTE-E-----ESH----------------------NSVYLFVGQNRHFLSS-
STKVCEFENQVGILNEH-SLSALEEK---EK-AT-I------QSYCNVSSNHCRS-----
-------------GRP-LLVCESEADGEEEQDH-------HVVLRQTQA-----------
-SDFIYKTINLALDKDTL--GETA----VSLQSKSVCHRVRGPEMMAQDESPAHKGGGKA
EGKSESGLLGKSLHSKGCSKEFKLPQTES-------TYER--FQSVISSQ-EKNL--SEC
KGSGR-SQE----TLNP--KEEPSGRKQNKRVN--SADEMARLIRSVMK--LENGILEIE
SKQNKQLYAPPTQGVSKESVFQDQ-RDREMADCALR---SGSSGNHLSFKDQPSSPKQID
DITFR--DSEAGEM--EVNNNIGKGPQ-VRKIIL----SPFKLRECIQDIKFMTEHPPP-
-AVLDRPSWDTC--DC--------------VGTCTAGRG-----FADTCGN-PR------
------------TEASASALPSQPRLKMSSEKES-EAGNA-----S--AC--PRGQPCSL
GGLEELETV-----KDFQESQVAKHVSSS--------------KQKGPKAQGRVEEMIVR
TGGSLLEEDK-MVSWTQKVPSPSP-HCVSTSFSQET-GPLLSQPDSS--VAAHRDL-SGT
LPLDSARLPRNYLHACD-SVH---ID---YVLDPTMFKMTDSP-LVTGAGC-QDQSGEPR
SYSPQG-DVR-----------------------------------GGFSLAHTAWCESVI
AT-------AMASHGQFHVPES--ISLGAESRRSA--ST-QDEGGDLRSIVMGMSPRESF
ASEAEAAVQRGSERASPLKRGFSPLEK-TSCLLEEGNSQGQQ-AKQK---AEKEAKDL--
--SP----------------AGGAFSAPVSLP----------------------------
-RVPHPEHCA------HTSTDL-----SVLEE----------IRQAKAQGKQLHGLGADG
NVLPYYVTLLEPEHSSGARGRPQCPQRD-----------QSVSDRTRNEGEAQGFYVTSL
SAEPGHL--STD------EA--------TPL-PADSFQHLPNTETKTG------------
-PRHPSQTSSHAAP--VPGKSHCTGER-RHFLGAGERFVCHCSSSEIMEEKKKATRTPSS
ADPVSS-DSFPST-LVV--DRRVRSE-----------------------------KA---
----------------------------------VAALSSWALSGDPGMILC-----GGS
QL-AQWETAEGTRPGGQETNPVHHGP--RILDPTCG-----------GGSGNFSVAAQG-
GK----------TTCSESGLVTCDVQNSVSLSGRTQDHGRCFEASIGLEEGG-ASPKQGT
ILPGAPRRADT-----EAPSQHHMKWEESDDCGLAEA-CSPAN----------------S
ASSKHPR--PT------------------------PLPYQRPSPDS-EVQEE-SQCRHPQ
ETLDRVVISGRMEGSRALSPPRGQEDSGTSPCWHLCNPQPM-DSRACASLSYTLSCYRDG
DLRKRSAKTALHTLQPPCIVSSRACGMDETAESYSRAPEVLWTPGL----EPKGIRVVFA
PADISSWEPSASAPVLSLAQEGSSPSA-PDVM-TCSLSHSVADGSSRSGEDPEKKVA---
---EKKAS--LEPEATFSSADMYSEPLREFQDSSVGGQNAQDSQ-TKPEPP--LTTGRPY
TLNLSEGSIESELLGE-PQHGCLEDA-IQCLPEKPQLSTESRGHSG-LGPQARFVAKLKH
ISRH--QAD-SPWDEEEQQRHQAS-DGREEPAQGRS-----SQPSHE-GGLDSCRIIDAG
RE-----------------EASVAHLSVSKMLSSGFEDSASMPLGQSGAPWPTPQSPG-L
PASGREQLAP-HHGCSLPVISVFSGPKH-SRSSPRPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QEPNRWWTPHPRGHFKGKSAA------GTSLKAEGCSQKASSNWD----MSTAG
HQPPQPANPPY---PKSSDLSC-------MPIP---DFMTGWTSSTLE--ESWQ-EN---
------PEKWHSR-VDKGTLHFGSRDINPYILSSRPEGPVHIGWKQYVFGSAADVSCTQ-
--GPIPSNMAHCSS--MDDGLEDQNSPLHSHLSTYANGRDLGSTQSSIRNAQGSHEAWEV
WG--SSFALGSPHILNTREGTIPSKG-LDKRAQTLGTPDEAG-CLRSRPLL--AEENAAG
PVDEIMLLYPSEACGPVGQ-SRMNTLEQGTQTLG-CS-------VCWSSTDIS-AQPETS
AVPGS-GLVSWTSMHNLSLHLSQLLHSTSELLGSFSQPSVAEKERNVK--RESPDEMTQ-
-ALMMDCCTQTTMDEGIQTELALP----------PLHLP-TPEANPQEVNV-VLEVLGS-
---DVPIMS----------QKKGHVTGILQRREP-EETAWK-MAG-----PSESQ-----
-EESPHFRPQSFPAPA-YHSRLQRAHFG--QNLPSVIPQASLNASLSPSVQAEEPSCLAV
NSPSL----KGSHSPGPCPSP-AESMGNP--KVQKEL-GTVGTLLVDRASSPILTLSAST
QGLGLSP-DSLSLTAPSA----Y-----------------LFL---DSPRPPVDNYSQIV
NESGDS---QRVGAPCGEGGSPL----ERS-----DGSSLLEVRSPVSPPQ---------
-----------SPKLQVCFIEQPPQQLQPTTTTL----------VQS---------RPPP
PSLRSQ----SPNLAVDFVPEDVAS-LECGSLSSREP---SEWRSKTENEG-------EP
Q-PTLDFSS-SRGG--L--------HHLRP--CSVSELTA-----------TAGL-QGPT
LSP--TCQSEVLLSS---SSQVCMAAEAQHHGLRDSSVHNKVSHWSGVQDGSPGGLDV-E
-SLGTRCDLSS-GKQGQ-KPLQS---------PDNQSQDPEWSQR------EQIPLQIGA
QNLSLSTELTEAKLHHGFGEADALLQVLQSGTGEALAAEEPLQSTWE--ELFARRLIAGC
SFLLCSILRWRRAFRALRRERAERLQNLHQTRNLSPQKQLSLLPNRDLPTRDLGLPSRRR
EYLQQLRKDVVETTRSPGSASR-SAHPASDIALMLQEYQRAREEAKVEIARARTRLQERT
EQEKLRIRQQIISQLLR-------EEEKLHTLAASSSLSAS-SNGSLSSGLTSGYNSSNA
LLSDQLQSPDSVV-S------------------GQILTM--SHGARA-------------
------------------TETGVGA--GSSE-----------------------------
------------------PSSHLFFVFPTLGVPSHQGEEQEV---------HLYYKMFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPT

PF01852 // ENSGT00890000139327_7_Domain_2 (5671, 5806)

LWPLYHKPIQTARLHQRVTNSINLVYLVCS
TALCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRDMVRGEILPSAW
ILQPLTVEGRDITRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKREIANGGRIIIEVDDKVAKIKNLKVDSRPDGPGGSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMIGTPA
SLGLTP-RICE-----------------------------GLFSKEDDSSNQPSSCRIRV
SFLEIYNERVRDLLKQSDQKKPYTLRVREHPETGPYVQGLSQHVVTNYKQIMSLLEEGVA
N--RITAATHVHKASSRSHAIFTIYYTQVILENNLSSEIASKINLVDLAGSERADPSYCK
DRITEGASINKSLVTLGIVISTL-AQNSQIFIGYQSPNSTS-SEGSSGGLSCSSV-AGSI
GGAPRKQLYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPANSSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVRLIRELREEIQRLKGMLLSFELGNL-SPFTNEKKGNLRELVLHDEFK
RDQLSKDRTQKWDTWKALLEQYSVDINKEKAGVIIESSLPHLIALDDDVLSTGVVLYHLR
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSVCGVVTLQPALGARCTVNGQEVTASCR
LTQGAIIILGETRKFRFIHPAEAAALRQR-RLLGEVSAGSSNCSLKWLNLDGAAPAPHLG
IE----E-DRTVCGAITEAYHQKRLDLAVSHRTQIR--HQKRLVKDLKQDILVGRIRAEQ
ELEFDQALIKQEIKAKQQWFLKEENWLAGLQRQEDES----VLTET--------DSKIPH
VTKSRIKLESEASSSSLD-GGRKRLVQLQILWKNALWAAERKVRRKKVK--FQLEGIIKK
QKLLEAQKKLEQLETLCWDDNS--SQPMESEPSLDT--GFLTHKKKSKFSSSYSSLDN--
QRLC---GLPLS-------------PSQSTLKCEITAK---LSAEAAH----RTPEIPPL
EEYLLQAS--VPRGNTSSLNNS-CSLNRWEFCERKRASFGEDSLAQRARSTTSLKIAPAM
NRKCQEIDR--KKELAQLHRNLVSVSRSAEQLQSREK-PDTFIARPQIVRAKPLGSY---
-GQLPRRWRKEG-QLLSSRAF------RGNSPQGA-----RARSLLRGRFQASRLRQAAW
TFQHWEPSMA-LSPRASARLRG--HLLSRRDSRNKRFLQVPQS-PENSEGEKRTRSTKGL
LVSPGSLSAQPQEKGNDFSDSDSMYSMDSLSYACSRS-LLKLQEQEAPEPKP-LCSEPEN
TESDDSQMSQDSLMEKRSRTQRWLLPPPLPPQDSE----RSEAESVTSPEG-PHLLLGGA
LSWENVRAISLDSLDNEEEEEEVEASGGESKKALSPDEMPAEAFWQMKSSQSPTRCP--E
KVLEFQASEQGPGVAEPDVTLKPCDSFYLASQPQP------------------QPQPQL-
---QPQGEDCKPLQE-TPNLRNN---SLASLESWFSCESGSHHNSSQEVPRYSQINLAVP
ELK---------VQEMEKLKA--------------PVEGGELQKPVPKTASTRHSFSRFK
GRASVSSTTSEGNS-ESTSEADTTWASSNLR---SDS---SVSQESFHMEGIGLPKLAGY
CSSALSSS-TLSSSRSAAPASLL-SHKGSSTLRKGW------PIV--EYLCEFSHSSLGA
TVKSTQ-----VSSCPQKDT--SCRTFTSGKRWDSFFPLCSEIPGDFDFNNLSFPSSSTR
HLRMEQEQDDVSFELDDLSSFFRMIEKDAHH-GSSP----TDLDQGD-LSFEN--AWVFA
TETKVPTSMP-----EMPQICQGSSEQ-PQ-P-LRKAGSTVSFDESFFLRDISNNSSP-M
TVKEDRHPPAWTQQEKIPPSKQAPLRVD--GP-LPQPVLKAEFFQASN-EEIN-TESFS-
--LAFPTDSELF---PPWDPFPSP-EQLSPLETVYVLESRDAVTETALEIPACRDWGDDT
LPTGRVEGLSNTFQFFRNL--DSDLLLLLHTPNHKKPSFQ-RIGT---ENSFGPGTWEDP
D--G--TGVPQ-S-----MEIYN--------------------NPVSFSSAQNRLLLESI
SMATCQVGKSAGTLKNNHSKSPLT-K---ES-AS-A------QPLWGVPFNESGA-----
-------------TKHLPVMSSIEVDHEHSQSEDDIQGKRAVYLLGIDSADFDEQISSGS
NSNFVYNTEGSSQPQPRA--NMQEKVLGPLQCSSSSHSESTSPVMMGKDETLSHPK----
-EETESVYPGMFLHSKDSSEELMLSGGDQ-------DHSY--TKDSTLNLLPAMS--TNA
EGPIV-SEEPESLMVIPSSQGRKSRRRASQGKIVGHSDEMARLISSVSQ--LESSIMEIE
SRQKYHPRALYMAEAYKRAMFRER-KDQERAHLPRR---PKDFRNSLYYKDQPRSSKRIQ
EKEVVPYSTEARESKELVDTCVQVSHQ-TEKIPP----NLTMPAEFTEEDKTEREPTLL-
-RVPEPSARDPS--DY--------------LLIRVSQRPTAQKDPTNVPESPEI------
------------VEPLARIESSRLKEERFEGTCR-EEPVV-----E--LNP-QSYASIGT
GSGPDLEPQ-----VSFQESQTAENLTSTMITA----------KYKEPRVCDRETSP--L
EEKSLPTETQ-PDPLAQELPSLSQIMHMGRFHTQEMAHPLTSQESYP-VTSTQEEP-SNV
FLSDPPKLSEGYFRAPTKTMSFSPTN---YERELQFLKMQGTP-CLEGKVEQQKTNGEVR
NHSSLR-SISC----------------------------------KDSSVEESVWQRSHC
QL-------NGSGNG-SGRPSRNNYSLEEMEASAPAMLM-EWQERDSQVTSKDSNLGNLS
LTEAEVTLLRNIKKANLLN--QCPLEKRTNQQWSDSDFQVAQ-TLEK---KLWKIDDFAM
DPSTTGSPLSASNEGNLAWVSVGPWGGPASSSRYSEVNEETTVKDSTPSEEGGKSSKDSS
PKVSSFSSGPWG-TSTNSSRYSEMNEEATMKD----------SRQPEDHGKS-----SKD
STCDIIVPLLEPEVFSGTSKQPHYSQRD-----------QQESERSKKENEASGCLVQNK
ATRGNTQ--EASSGT-VPEK--------H----PDKNKPLANLSMADGLQLMNDVTPPSR
GQDHATQLSSGTIT--IPGI------S-KSINTQTGDFACGSSEG-----KEEDI-RSSA
GSLLSS-GNLPFLSTLKENKTDEIPR------QHLFTPSLHA---ISDRIKVIQQELNQA
LPSKQRGELLEVERTFPGSKENIRRAWGGLKSQ-STAYESWCSGDSGNSSEA-----IGN
LQ-AHWETSIQSPWKDAS---LHAGSGISMAEMAYMTANSTTLWPVFVSQGSFHIRKQP-
GSYEAEIVEAKEPPYCDSPLEALDIKQAGSFPTHP-SHI------HSLGEGGEQASHRED
MVSRTVGGGIT-----GDALPQCPKLRGLAVSGLSVP-Y--------------------S
IGSKGPR--PT------------------------FLLDQRSASAFVGEMEN-----CPE
RSLIQSTLLETSESNVIANSSPSQEEPVASPARPPCISQQG-PVWVNSPLFTNSLSHGSS
DPERRISRSASDTMLPVFLGPSKSSVPS-----QPNVPNIPLAHNL----DFREVPPEL-
-------------------------------------KLEAPNTGLFSTEGPKKED----
------IK--AKPEATPSPVSTCPEKLENLQETPKTSQNRQAFP-HVDESGNHVAGGRMK
AIPVSEGIPKNELTIG-SLHLSSGNS-DENLAPGPSFSKDPRDPSA-PVPHSRTEAGEKF
VCSN--NLPSSLWKKDENEQPLSN-IG--NTMWDTN-----CRRSGASGQASPPKARDIA
RP-----------------EPKSLKVLF-KRTSDPFDVPRACPL------------PG-D
---SQVCHQD-SQGASAPSVALTSIPEYPPKNFSILKFSSRTSSRTLQELNMS-VEPPSP
TEDEE---SHGIEKPGLSDFSPEESEMMMPVDLGKLPRYVDCNQTAVSNSN----SEAPL
PQAPEPGPATY---PTSLPLLA-------KPVR---ES---RLSES----------LVEE
QNGHPRNREWLAP-ETMDALHFISNDITPFLQSWQQEGPARIGWKQYMFGSASDISCSQT
SWGLDTQRAIRCSS--VDNGLDSQSSPFHSYLSSYANTRGTFSTFSSIEDPQGSEEERKV
LT--ASHIFKNEHRFSYTSTIAPSARTPDNAG--EGLPEKGRLPEGENVPA--EEGRAPA
QAEDNELPYPLGPEAWP-K-VSKVTCDQGTVTLA-LPPPQEVHQHLHNCVDIIHPNPEAA
IFGAHPCPSTWTNVQSLSMHLSQLLHNTSELLGNLTHQGMAERERAMK--AEAPEEV---
--LRVDSSTQTTVDVGIQTVGMDSTSR--EGSSLLSHRE-GKLASPQEVTV-TAPSQGF-
---KAPDAS----------QEKEDRSLGLQGRGP-EDTAKK-PIS-----PSPGS-----
-QR-LCVIPQNALGTSHLSVCFQKLFPG--QDLFSLRASRVTSSALS--SHV-DGSYAAA
SSPTSGTVSSVSSTPSPQEGG-PAGKSGA--QKNKKE-GFRGALLVDRASSPILTLSAST
LCPRSFSSNASHAKSPRS----HSLGHHQPPG----------------VSPPVNSSCQTC
HEGKAGEVSKDVGNAAG--KNPS----KGFPAPTPSGAMKQGGWVPG---S---------
-----------STSVSTGPLNHLQQQQQLRTSSESLSWEDHQAGAKKK------PFYLSL
PPQGPSKEQPEASGPHRFLAEGA-S-EAPKPVSARLGSQEARCPKRVEAGANPPEQPLQS
P-PAPESLP-WGAV--L--------SH-FH--CPISVSEVS-V-----------A-PAHS
SSLARDTQSEVLLSS---CTQKEQTPEPKHYSLRDLPVHNKFSNWRGVQGISSEGSVPPA
-VANAGSTSSE-GVEKP-T-------------LLRLSQGPEQLPREQVQVLAGVPLELGP
QGPPLSVELAEAKLLYGLGETDALLRVMQTGTGEALVTDASASPHQD--GMYFRH-----
----------LKTVEAVRKERVDRVQSFRRARSLSPMKQFHLLPTQEAFPRDPDLPSRRR
EYLQQLRKDVVETTRNLESSSDAASHQPSDIEVLLRDYQRAREETKMEIARARDRLRERA
EQEKQRIRQQIVTQLQR-------EEAKLQNLVGVNTLCTTSSADSLSSNLTSGYNSSVL
TLAGQAQPPEKQG-D------------------ASVPCF--KETSAGDMRGRSMVRNRQL
YLKPAGESHHVS--LHGSHKSLL------------------SQSNSDSCLPTSPGALYHD
LVKHILASTMTEVMAACSDNLQNLFNCQAAAGWKYQGEEKEV---------LTYYKAFPS
-ATRHGFLG--AGVVPQPLPRVWAAVRDPTMWTLYDKSIQTAQLYQRVTSTIKLVYLVSS
TSMSCLKQPRDFCCVIAEAKE------GQLAIMVAQSVYDKAMPRPSRNVIRGEILPSAW
LLQPHTVDGKEVTKVIHMVQVELGAPGLPPGLLTHCAKQQPLVIANLASFLCG

-----------------RERAEGGRVIVEVDDKVA

PF00225 // ENSGT00890000139327_7_Domain_0 (36, 421)

KVRNIKVDS----SWDSREKTVSFS
FDYCYWSVDPEDPKYASQEMVFQDLGTSVLSGAFRGYNICLFAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFSRKDDYSDQMASCRVKV
SFLEIYNERVRDLLKQSDRKKPYTLRVREHPETGPYVQGLTQHLVTDYKQVVKLLEEGIA
K--RITAATHIHNASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQMFSSCQSISSIP-SEGESGGVDG----PPSG
GSGGRRPAYIPYRDSILTWLLKDSLGGNSKTIMIATISPASSSYNETMSTLRYAANA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIDRLKAMLMSFELRNSSPSWSDDRDGNLTERVLQNEMK
IEQLTKDWTSKWTDRKAIMEEYSVDINKEKAGVTIDSNLPHLMAMDDDILSTGVVLYHLR
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRSDSDQDQDIVLQGQWIERNHCLIENQGGIVTLRPVPGARCSVNGSEVSGSCR
LSQGALVVLGKSHKFRFNHPAEAAILRLR-RSINETPPTLSCGALDWLNLDGSCINSPHY
ILSSLYKKPIREIDAVHEEYKQKLRDQEAFHRKQIQ--RQQLYVEDLKQQILRGQIKAEQ
ELENDQALINQQIQENQQWLINENKRLAALQQQQ-----REFAVQT--------ESTLCA
EAEVQSIPGLETCLSLLQQNK-KRLVQLELLQRYSLKKAERSIRRKKVK--FRLERIVKK
QKLLEAKQNLEQLEASCWLSEECVKQPQALSDNIAVWSSLDHHLQKRQKSLGSSSSQH-R
HLFC---DSYLPQV---------------------PRVLLSTSPNTDQHCKGGTTGRLSP
VEYLYRSGKDISGSDDLNDEKGISFSIQRQLTEKNKTSSI-ENKKGAEKDSNDSAIMAYI
NKKYKKIEKLDDSPGQAGSQNQTSKGSSPDLFIEKDE-PKTFITGRRMTKSKVLGDL---
-SQPASSNVAQN---------------------RENFPKQMKK-TVYGNPPSLHLNQTVK
NWKREENSVLPSHEKSSVEQKEFLMAATSVGNLTKMNSQTPLSYVEKKWHSAEILSAGVS
KTATDVLGNWQEDDENEISDTDSSYSVDSLSCAYAKA-LPDKLKLEDFDRNK-CLANPED
SESDDSQMSQDSLIEKENKAKKRNTSQFHKLKAHHEPAKLFKSRTENHISSLVTSYASHR
RLGKAERSFSLDSLADGEE--MPVEDLVEESKSDSSDEVPAEIFWKLQTPKLPATQI--E
EDHESKTCDRDTE--GTNCDVKLSSSFYLNTKPQTA--------------SSNACKQLLK
GAKVSFVEQERSLDRRLYYASGN---PLLADDAWSSCDSKVDTSNPRITASSSHENLEFQ
DAHLCSLSKPELWLKKDDLKQSAAEVSF-VSGSKQIHSITHSPHLVNQINS---------
------------VF-SSDTLEVPLPETTTASGTSENGSLNKVFKGWTNSN----------
ENSSLESQNVMSSFVSSVGSSS---SFVPTSADHDYHEHSRSQHPEQEQLGELS--TYRS
ATECAG-----TFSCLESSSTADCLSLVSKKEESSLPTTHPELPKNHTLKKTPFISVLPV
QI---VEQRNGCVDADLEDDLVRSFSKDELDNDYNNLMTKSSVTDSS-SGSASVSAPAAE
CSMGLAHNMASTQTSAVKHIQFGNCGQ-LF----PVQKIPTCCDEGFFLSDLNKNCSL-V
SSY---KLQTVAGQGAESADTEELPRSG--ES-NLETMQETDHEQTPA--EVTAETDFSS
QKTTYQCHPLVVAVSASYDQSATP-IEMPQKERICMEISTDSLADIVPEVPSFSDHEEYV
-SKDEGLSSLNHYEFKCKPDSKDYSPDCALADNQTSCLSQ-QIS----------------
ENYTLCTDNIREVSRKSKEHNVLNSQAVVQKEFSPKYKTPAVNEVGYFLLNVNGKNTESF
PAAICENINDFLPESNSSLFYKVSTKGNIFQSASETENYDKLLQHVTVVKGDCDATSNLT
VEVSVTESCSDAHSGCLCPTCSSKSTGQ--------------------------------
-KNTTHKMTDISAEFNASILLESETHNK--------------------------------
-SLIESREEKEAFFESDCPEDIIRVEHDANT-ELGRVFECNTNASAAISQEDSSYENKES
KFFRNKEMDTEEAMA------------PYQNTGTARDEEIIKQINNTSL-------SEYR
DSQD----SSYENKE--SKFFRNKEMDTEEAMAPYQ--------N---------TGTARD
EEIIK-----------QINNTSN-----LEKSAL---------EKCIKSRHTESLPDRP-
PAQVQSVSEDRSGKDFKDISLTQNPKKPTDMAACEVLCE----FNTNLCLTHEEVDKDEL
QEAGTGAEHTQESKALEHSGS-QLETSNFGQKEKSEKIEAGIYSTELSVAPKTTPSPVCS
HTTAKLENEGQINSNNLIEHCIPNC-----LPQEGKVNECEVTGSEEQITMTNTEELVIM
RQEDLCTEDD--------------------------------------------------
----------------------------SRCHDPSE------------------------
-MSEDGDSVDSATEIGNVDACEYSVDDNAGIDQYRTEQKFTSVG----RHRYMSCS----
-V-------QSLEHSTSEN-----LNVGIN------------------RKSSDICELDQV
GSRAEEE------KVQLLKLVEMAKADKQKQIFVENTEEEIM-------------KTLA-
--------------------SNKIHQHH--------------------------------
-RTVQKKNKNCKTPHASLPICL-----YILEEDV--------PTALKGCTKPSNSNLGTG
AVLPYYKTLMESEIGVDTSVTAS-KIED-----------EHLPGKTQSR------SVALL
QTRTMQQ--RQEEESSVFKNGPDYPISVQPVNENSSFTPYSAGGLESGTLVLQQRAE--G
SSFSLEKLDSSEDIIQDTNNAYEEHSMDLMVNKLLKDCLN---SIENTAQEVKDAVVPDS
LALDTL-NLLSSSEKEE--IDSALS-----------------------------------
------------------------------------------------------------
-------------EGLDKSS--KENP-----------------------HYSSLIVSNG-
DKGKNGIVLSEETKYFESESTDLNVSA--TFPGVSQKGDGKE-NNSAVA---EATYAQSN
KLPEKVVGTELKEKIVQGYFQNCGDTKEDKIHEFSEH-CSNTNSVTIPESGLLTFQSQGQ
TGQDQSKAPPSHSAEDTPPGTAFQSSKSFGTFNTSSLLGDSESPVFSQLEDS-LQDSCLT
EKASCNS--------------ADVCSVKEGHLPQSFARVNY-PALTAFSEFPLTADIGHG
EISTCDTSHSNILKQSPFA----VLQIQDTQSDKAVVFDEPVCASGSILLSLAKENRHFP
MSDINCISYENSALDEGAAYGSNSKKPYSDTK---------IDQHHWD-KVPPQDAC---
---NKHIQKIPNDDSLFLPSLPFWDTRRAI-------------------PI--KEGQMRN
ILNESKEELHSNIEAE---HFTIKTEQRKTLS----REPAEKQPYHTVLGFERNPADLQD
NCQYVPAGE-----QIEQVPDRTYTGGRKEILLCKNNSCPSIDSPAADAGTDTCSAMGDT
IMRNNTLKSGGLNFSVKSNETTSIKFLPENHDSTS-------------------------
----QESKFMQSHRVSAPAIAVFSDTEYTLEASSKADPVLYSASKSLQDLNMS-VEPPSP
TEDDF-YGIERFSKQESKDFLQVKSKPRFQQKKAQTKKLASCDPKNLQNFA----ARSQS
IQSLKDCTSQSPSPSLPTACSTVCAEANVHSKS---SSVAQCSEGKGEEAGYRT------
------ESDLFLQ-DNKDVMHFRSSDINPYIHPWQQDGACKIGWKQYVFGSASDVSSNQI
PLNMENRKVMRCSS--VDNGLNSQNSPFRSHLSSYATAKVLSSTLSSIEGLQEWDSVRQD
FQ--SACSSDSTKQYSNISSETLETNSENN------------TAELENPSA--QPGNSSM
QVDEIVLLYPSESEKSSKK-PPGITCEQGTQTAT-TGRYKRQRRHQRSYTDVSAKKEETN
RDLFH-QPSSWTSVQNLSMHLSQLLQNTSELLGNLSQQSIIDNETNAKINQKGTEGAVK-
-AIRSDSCTQTTADVGTQTEILEKPQS--K----------HEEKQI--VNV-DWKGIGA-
-------------------DTVGEIPKRKEETSSLEERTQE-QTGMKNLGNSDFHDSLDS
ILEDSFMHLPCLLKTSTPTLLSQKTSLNAQQNIAFAGTRASPLTSSLPSSGQDGSSCTVV
SSPTN----STSQSPTSYTQD-KRSVNETETPAERKF-WYKNTLLVDRASSPILTLSASP
SSQIAFSKSVCPNKEPLG----YSSVASSPLH-TQRKLRAGPQ---FSMQHHVDSFSQTE
TDSESSTS-REHKSIR---KKPGTF-SDKK----AAKEPL-GQDGSKGLEQQHSLRVDTH
TTICAERLYHSSSMLEVSGHSAVVTGDVRDQG--SVA-----------------------
-----------HSLHCMY-----------VTRGGRGS-------SGKTNAGTSSEPLVEA
--SSLQFHDFFWKN--E-----------NSCPPPVSDA---------SDVQTSFREDSTD
SVTGSECDTEIPLSR---NTTPAKPHRPRSYSLRDLPIHNKFSNWCGVKSSPPPLLLGLS
---GSVTDLRS-QAEKKPRSSRSTEM------------------EERAQIMSSIHLD--L
HQHPLTVELTEAKLNYGIGETDALLRVLQRGAADEPGA----IPVKQ--QLYERH-----
----------MRTIETLRKERVKRLQRYQRSRSLSPQKHLSLSQTLDASQRDLDLPSRRR
EYLQKLRRDVVENTRVQEPKRR-SVQHPSDIELLLRDYQRAREETKTEIARARDKLRERA
EQEKRRIREQIFSQLQK-------EEARLKTLASTSTLCTD-SSLSLSSGPTSGYNSSNT
-ATYTFVFPTSNGRSH-------------FCTFLNQ-VSSGNTLVSRDARGRSAVRNSQL
FTLEQLHKASTGT------SCRF-------THG--------LTIS----VNSSSTKGYQD
LSKHILANATTEVMAACSHNLRNLYTCQAAAGWKYQCTEEEV---------QVYYKVFPS
-ATKHGFLG--AGVIERPLPCVWGLVRDPGKRHLYDSSINTARIHKKVTSHIHLVYLVTD
TSLCYLKQPRDFCCITVEAKE------ENLSVLAIQSVYDASMPHPCKEAVRGEILPSAW
ILEPDIVNGREITRVIYMAQVDLGAPAIPARLLSSMAKRQPLVIARLAHLLSA

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---------------NKENMHFSSSDINPFVHSWQLEGNGKGGLKPCVFNSTSDVSCSKF
-----QDKIMRCSS--VAEGLNTHVSPFHSHYYPLSEEAVALN-----------------
----YDCGPQHD-----------------S------------SYE---LKP--KSENGSM
QVDEIMVLYTSESETCNND-IIKVKSEQ--ETQT-KGRYRRLNRHQRSHTDVSSIKGAKC
R--NQ-RPASWSNMQNMSLHLSQLLYETSELLGNISQHDSGQI------HADSTEKAV--
TKAMRDSFTQTTVDRGIQTDCQVSNYMQNK----------DDEKENLRSNI-IVAGTGS-
-------------------QTQHQKS--QEKQTAHDASIAK-TQSLPNLHDVSSCKQREP
LYSS------SHVRTSTPFLAHMPAGIS-PSSYA---TRLSSF-SPFSENPPSEGSCTEV
GGSAL----SATQ--TLYNI----EHNTTEKLSERCN-VGEGTVMVERATSPILTLKASK
KSLHKNT--VAPALN------------------SQNMVKVLRH---RSTKEHG--SSETG
SDSENSTS-QSSSEKANTFRLPSSRESAWKRLKEDHKRPYRFKSEDCIVREEHPFQRNRS
SSIS-----------ELSSIGRPYK--RRDKGDGTSA-----------------------
-----------TALNAQH------------PL-GRS--------PSLENLSPIKQPAPNK
ISQSKRYPTL-ENE--F-----------ENYPIPSSNLLLKDKSHSMSILEASHFQEDGL
SFVESGCNTDVLLNP---DSCTSTSRKSHNHTLQGLPMHNKFSNWSGVQCTPSRLLPGSP
---ANPSLRDS-PTKTEYSMQKEEQEHSPITVDESRTREIEMLQRERVEIMSGIHLD--L
NLQPLTVQLAEAKLSYGIGETDALLRVMQNGTTDDKKDI---TSLKK--QLYDRH-----
----------IKVIEGLRKEREDRLQIFRRSRSLSPQKQLSASQGSLTSLRESDLPSRRR
EYLQQLRKDVVDHTRFQEPKRE-PAQCPSEIELMLKDYQKAREEAKSEIARARDKLRERA
ELEKKRLQQS---CLIK-------EETKLKSLMSTSTLCTS-SNLSLSSGPTSGYNSSSI
-TATQDK------RSHQDLKE------------TKT-SSRRMDLAPGASRGRSAVRNGHL
MSLSQKEPVPGLK------KSSQNT--KECSPN--------SCIGL-PSGLSHPAVSYQD
IARQAQATAVTQ

PF01852 // ENSGT00890000139327_7_Domain_2 (5593, 5809)

IMAACCGNIKNLFQYQAAAGWNYQCTERDV---------LVYYKAFPS
-STKHGFLG--AGVIRRPLHDVWGMVKDTDTRHLYDKSILTAQVHQRVGNNIQLVYVRSD
VSLCYLKQPRDFCCITMESKE------GAGYSLCFQSVYSESMPRPSSDTVRGELLPSAW
MLQPDTINGENVTRVVYLLQVDFGAPAVPSRLLKVISKRQPLVIASLARFLSV

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-----------------------------------------------R---PCSTSYDTK
NSKPEQRPYLQSHRLSAPALAVFSDLDDTFKASSLADSLLYSASRSLQDLNMS-VEPPSP
TEDDL-HLIERFSKQESKNILQ--------QRMTHTKKTANCDPKNLQNYA----ARTQS
SQSLKDSTVHSPSSLLPTAHSSVGAKENIHSKS---SSVAQCSE----EAGYQP------
------GTDLFLQ-DSKDAMHFSSSDINPYIHPWQQEESCKIGWKQYVFGSASDVSYHQM
PLNLDNRKVTRCSS--VDNGLNSQNSPFHSHLSSYATAKVLSSTLSSIE-----------
---------------------------END------------AAELKNPSA--QPGSSSV
QVDEIVLLYPSESERSSKK-SPGATCEQGTQTVA-TARYKRQRRHQRSYTDVSARRQETN
RDLFQ-QHSSWTSMQNLSMHLSQLIQNTSELLGNLSQQNIIDNEQNIKIYQRRIEKGAKA
TSTTSDSCTQTTADIGTQTEILEESQI--K----------HEEKQV--QTK-LE---NE-
-------------------YTTDKVPKRKEKTFSLEERPQE-GTEMRNLGNADFHDSLDS
ILTS------------TSTLDFQKPSLNAQQNFAPASARVSSIPSPSVSSVQDDSSCTVV
SSPTR----SIFQSPSSYAQG-KRSVNELEVPAERKL-RCKNTLLVDRASSPILTLSASP
KSQNAFSKPFCPIKEPFG----SSNDASSPLH-SQRKKRSGQH---SGMDPHVDNFSQTE
TDSECSIS-RDSNGIG---NISGSC-LDDV----RDPSPL-ARSLRCMNY------VGN-
---SDTALIH--------NHS------LSD------------------------------
-------------SGLLF-----------NPKRSASC-------SSQANVNESSEPLAGA
--ASLQLHD-FWKN--E-----------NSCSL-FSDL---------SDAQISLQNDNPN
SVSEIECDTEIPLKK---STTLVKPYRPRSYSLRDLPIHNKFSNWCGVKGSPPASSLSLS
---GSATDLHS-QAESKPGSQQAVETEGKSQLWGSRSREIERLQRERAQIMSGIHLD--L
HQHPLTVELTEAKLNYGIGETDALLRVLQSGTADDLMT----VPVKQ--QLYERH-----
----------MRTIETLRKEREKRLQRYQRSRSLSPQKHLSLLQTLDASNRDLDLPSRRR
EYLQQLRRDVVENTRVQEPKRR-SIQHPSEIELMLRDYQRAREETKTEIARARDKLRERA
EQEKRRIREQIFAQLQK-------EEARLKTLASTSTLCTE-SSLSLSSGPTSGYNSSNT
-ATYTASK---------------------LSSWEGQ-VSSGSALLSRDTRGRSAVRNSQL
FMIEQLQKDSTLA------LLYS-------LWR--------GCEE----VSSSSTQGYQD
LSKHILANATTE

PF01852 // ENSGT00890000139327_7_Domain_2 (5593, 5813)

VMAACSHNLRNLYTCQAAAGWKYQCTEKEV---------LVYYKVFPS
-ATKHGFLG--AGVIERPLAYVWGIVRDPGKRHLYDRSINTARIHKKITSHIQLVYFVTD
TSLCYLQQPRDFCCITVEAKE------KNLSVLAIQSVYDASMPHPCKDVVRGEILPSAW
ILEPDVVNGRDITRVIYMAQVDLGAPAIPARLLSSIAKRQPLVIARLAHFLAS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPEGFGDSREKVVAFG
FDYCYWSVNPEDPHYASQDVVFQDLGMEVLSGVAKGYNISVFAYGQTGSGKTYTMLGTPV
SIKIR--YIPN-----------------------------GLFVREEDCASLPSSCRIKV
SFLEIYNERVRDLLKQSSQKKSYALRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGISSG
GAPSRRPFFIPYRDSVLTWLLKDSLGGNSKTIMIATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPQVNEDANVKLIRELREEIERLKTLLLSFELRNF-TSLNDEKDENLKKLVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGIVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5677)

GKAQKFRFNHPAEAAILRQR-RQVGEAAAGG--GSLEWLDLDGDLTASPLG
LSPLLWK-EGKVREEQCDEDHQPPRDGETSRSAQIQ--QQQSYVEDLRQQILAEEIKAER
ELELDQACISQQIKENQQCLLREETWLASLQQQQ-QE---DHVAEK--------DLEESV
VLDAWLQTDHEIQPSPFVQSQ-KRVVQLQLLRRHTLLAAEQNVRQKKVS--FQLERIVKK
QRLLEAQKRLEQLTTLCWLQDDSTQEHPYWVSSPDA--IVPEPR-CRSRSSSCSSLSP--
QRLC---SKHVPQLQS-------------VFLSLDPSTTLPPMPDPTH----QTSEKT-S
EEHLPQAASYSPRAGHRHKNGL-HSLGHGQHYTARAAKARKEASAPDTCLTMRSKS----
-IGIQEMQRVGKQPCQMMSQGLVSLRQSANELKPRDE-PKILTSTTQTRRAKGLADP---
-SHTQAGWQKEG-NLGTHKSA------MGASCSS---------PYPHGPKTTAGCGKAVK
TFW--IEYKPPSPSKALKRHQR--VLAARVRDITKKSSHLPLGCPLKRKQNARDPDTMAP
LTDFSPVEDHSREKDNDLSDTDSNYSVDSLSCVFAKA-QIEPLKREDPKGRKWDFPEPEN
SESDESQISEDSLAEKSTKSLKDRLWGNHPTNNHG----HPRIRARAFVRDFTA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELGKDQLEEAFPGSADEIPTETFWHLENSNLPLMDQ--E
AICRLGPISYRTG-ARPDAVLPMSSSFYLDPQFQP------------------HHAEAES
QVEPSYCEQADYLHG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFQPCDGERPGYWLNTEELKLSGADTVP-PDSSKLHQGSTELLCGVRDE------H----
-----------TTS-ASDKSRLSLWGIQRLV---QPG-----ADGTF--QGRGIPDMTQQ
GSSEASHNSSVSNVLAASATTL---THAGSTHERDW------SALQQKYLLELSHPVLEA
IGEPRP-----AFSYLEEDS--GSLAQASRKGGDTLFPVGPRVSSNLDVNNFPLHLSRIR
RLRAEKEQDSLNAKLEGVSDFFKTSEKVVSYDETYS----ADLESLAACESTD--AQVFA
AENTIPNSMA-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSTVT-T
ATKADHWPQGWASLRKNSAVQPRQLSSN--SH-HPLEEEKIDCQESSE-EVVRRHINVS-
--FAFPSGPELYLHSAPWNPFLPS-LQPPPLETFYVTKSRDALTETALEIPTCREIRVPS
PPPREAWGFGHNHQVLQNAYLKSNLPVLLQNQNSKSASSQ-QVTA---EIPVDLNTREVV
RESGKCPGNII-D-----ESH----------------------NSVYSSVTQDRHFFPST
STKVCEFENQVGILSKKHTF-PALEG---EE-AT-A------HSCCSGSSDSTVS-----
-------------GKPLALFCESEAGEEEKL----------------------------D
PNTVLSQTISVGLEKDMP--GESA----VSLKSRSVYHRVSSPVMVAQDESPTPKW----
KGKNETGLFGKALHPKDSSEEVKLPGTKP-------AYER--FRLVTCPQ-ERNS--SVC
Q------KE----MLNP--KGEPFGKKQNKRVN--NIDEMARLIRSVMQ--LENGILEIE
SEQSKQVHASHVPGVSKEFVFQDQ-KEQEKTDHALR---PDSSGNALPSKDQLSSPRQTD
DTVIR--DSEAGEM--EVNN-AG-NHPQVQKTTV----NSLRSREGVQENEPVREHTH--
PAGSDRSSRDIC--AS--------------LGTHTTFRE-----FSNTFLHPQR------
------------MKALARALPLQPRLERSSENDG-QLVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQIAEHIS-S--------------NQEEPKAQGKVEEMPVQ
RGGSLQEENK----VTQKLPSLSK-LCRDTFFSHKTVSPLLSQTEFS-TAPTHQDP-SNT
LPLNYPRLPRSCLHASD-ALGISSPD---CVLDLTVSKTHHSP-LVTGVEH-QDQSAETK
NHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AVVSDSQSGVPES--IPLGTEDRISASSSP-QDQGRDLRITLMGFSTSEDF
ASEAKVAVQKEIG-VSSLNEVSRQPEKRVSFSLEEDNDQGSE-QRQK---AEKETEDL--
--RL----------------TSGVFLPSVSLP----------------------------
-RMPNPELRLLE-PFDHASMCL-----AILEE----------IRQAKAQRKQLDDSVARG
TVLSYCETLLEPECSSSLVGRPQCKQTD-----------QSSSDWTRNEGEAPGFHVASL
SAEQGHL--STDARK--DQG--------TSL-FEDSFQPLPDTGTDRE------------
-PWHPVQAFSPAAS--ALDKKHCTGEL-RQFAGAGEQFFHHSSSSEIIEKKKDATRTLPS
ADPLAPDSLY-LAPVEG--VRRVVSK-----------------------------ML---
----------------------------------VAALSSQAPCDDPRVTLR-----ELS
QS-VPQETAEG--PGSQDSSPEHQEP--RTLDTTYG-----------EVSNNLLVTTQG-
EK----------TAGFESQSVICDVQKSTSPSGPKQDYLQCPEASTGFEEGR-ASPKQDT
LLPGALTRLEL-----EAPTQQCVKWKESVGSGLIEV-CR--------------------
TGSEHSR--PT------------------------PLPYQRSSPSPEGIGEG-APCRYPR
EALDCPVFSRNTKGSRTLSPSRGE-ESRTLPCQQPSSSQPV-TTHADSSHFSTLLCYRGG
DLGKELFKVAPHFIHSPCVAPSRAFEMDERGEISSRGPDVHLTHGL----EPKDVNREFR
PTESNTCEPSTVAAVLSQAQGCSSPSA-PDVR-ISSFSHSATNGSLGLIGVPEKNVA---
---EKQAS--TELETASFTAGMHSEPLRQFRDSSLNGQNAQVSQ-TNPEPP--ATTQGPH
AWDLSEGSAESELVAE-PQHGCLENT-TRCLLEMPQFPTESRDNNC-LDFQTKFVAKLKH
TCSP--QDN-SPWEKEEQQRDQAS-GGGEGFPQGVN-----PLPSDK-GGSAGCQILDSG
RE-----------------EVAVAKPLMSKILSEGVKDPATVLLRQNETPQPVAQRPG-H
LCTVREQPAP-NHRCSLPVIAVFSGPKHS-ESSPTPQFSVVS-SYSLQELNLS-VEPPSP
TDEDT-QGPNRLWNSHLRGYSSGKSVA------RTSLQAEDSNQKGSSHLD----DGTAD
HKPPKPATPPY---PMPSSLSC-------MPTP---DFMTGLMSGTLE--QVQQ-GKPEK
LDVQIRPENWCSQ-MDKGKLHFGSSDINPYALSRRPEEPARISWKPCVFGSAVDVSCSQK
PHSLTPSNVVRCSS--MDNGLEEQNSAFHSHLSTYANTQDLSSTHSSTENAQGSNEAWEI
FSGT-STALGNPHILTSPEGVAPTSV-HDRRPQFRGPSSEVD-CLRSKPPV--AEGGAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFKQGTQTLS-SR-------RHWSSTDVSFAQPEAS
AVSAS-DLASWASMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDVLDEAPK-
-ARMMDGSTQTTVDEGSQTDLALS----------SLCLQ-ASVAKPQEVNV-ILAGLGL-
---DTSTMS----------QEKGDVPGVPQKREA-EETAWK-MAQ-----PPYRQ-----
-EESTPCKPQSPLIP-SSHLRFQKASLG--QHLPSVSPSVSDAF-LPHSSQPEESPCIAV
SSPSP----SPSHSPGLFPST-SEYPGHP--RVQKKL-SPPSALLVDRASSPILTLSAST
QDPGL-PPGFLTLSAPSA----HSVEDHQKLD-SS---PDPVG-A--PRTP-VDNYSQPT
NESGGS---QRG-------RSSL----QRN-----DRRTFLELGSPHSPQQ---------
-----------SPKFQVDFLGQPPQQLQPRTTTGVQS-------------------RLLP
PPLRQR----SQMLADSFVPEEVAS-PEHGPLSGREP---SQWRSMTENGGEGSASPVEL
Q-CTLDLSS-SRRG--L--------QHLSP--CPVSELT-------------TGL-QGSA
LGLPQACQPEGLLCP---SCQMCMAPEPQHHSLRDLPVHNKFSSWYGVQKGSPGRSNLTE
-ELGASCDLSS-EKQ-EQSPPQP---------PNDNSQDPEWSQR------EQIPLQVGA
QNISLSMELTEAKLHHGFGEADALLQVLQSGTGEVLATDEPVISTWK--DLCVRQ-----
----------KEAIETLRREQAKRLRNLNQTRSLSPQKQLSLLPNKDRLIRDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHPAFDVELMLRDYQQAREEAKLEIARAQDRLRERT
KQEKLRIHQQIIS--QLL-----REEEKLHTLANSSSLCTS-SSGSLSSGMTSGYNSSPA
-LSGQLQSPENVG-C------------------TNLTDS--RDSWIGEERGHSAN-----
---------SAY-----SELRAMLGI--ATL--------PS---QGLHLF---IV-GHRD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPTLWPLFY

PF01852 // ENSGT00890000139327_7_Domain_2 (5677, 5806)

KPIQTARLHQRVTNSINLVYLVCD
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDISMPRPSRKMVRGEILPSAW
ILQPVTVEGREVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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PF00225 // ENSGT00890000139327_7_Domain_0 (87, 405)

TEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREENCAPLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKTYNLRVREHPEMGPYVQGLSQHVVTSYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENHLPSEISSKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFNSCQSFGSTV-SDGSDSGIPSSPSRTSSG
AGPSQRQSYIPYRDSVLTWLLKDSLGGNSRTIMVASEAAGAGSVLRLVL-----------
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--MSNVRVAL-

PF00225 // ENSGT00890000139327_7_Domain_0 (12, 326)

VRPLSKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXICLFAYGQTGSEKTYTMLETPA
SVGLTP-RICE-----------------------------GLFIREEDHPSLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEAGIA
NXXXXXXXXXX--XXXXXXXXXXXXXXXAVLENDLPSEIASKINLVDLAGSERADPSYCR
DRITEGANINKSLVTLGIVISTLGIV----------------------------------
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--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHDASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLQPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPPRDGETSHRAQIQ--QQQSYVEDLKHQILAEEIQAEK
ELEFDQSWISQQIKES-RCPPLNVTWLASCTAQQ-ED---HVAQPE--------ERNL--
------RGGEKNHHPIFPKAE-KVAANAAPMRRHNSRQPERCPARKSSKSRAALRRAPQK
KRLGG--KQLND-IVLASRRNSPPPGPPYQVRSPDA--QSPL---NCDKLTSCTSLSP--
PKGSASKHHSFPCLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRIGCLRKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQDMERVGKQPHQMVIQGLASLRKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHTAP------KGASCNS---------PYPHGPRQTAGHGKAVK
TFW--TEYKPPSLSRASKRHQR--VLAARVRNITKKSSHLPLGSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQDRKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRARASVRGFTA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPFPGSADEIPTETFWHLEDSNLPVMDQ--E
AICWLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELPP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSRPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGEGGDTPLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQFFA
VGNTIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWSPLRKNSAVQPGQLSPD--SQ-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNRQALQDAYLKNNLPVLLQNQNSKVASSQ-QVTA---EIPVDLNTGEVI
RESGKCPGNIT-E-----ESR----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPGMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
K-------E----MLNP--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVNKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPVREHTH--
LAGSDRLARDIF--ES--------------LEKHTTCRE-----FTNTSFRPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KGFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RGRSLQEENK----VTHKLPSLSQ-LCRDTFFSQETISPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRWPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVHH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGTEDKISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEKETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSLEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECPSGVAGGPQCKQIE-----------LSSSDQTRNEGEAPGFHVASL
SAEAGQTDLSTDERK--VQA--------TPP-SADSFQSLPNTETDRQ------------
-PWDPMQAFSHAAP--ALDKKHCAGEL-RQFAGTSEPFICHSDSSEILEKKKDATRTPSS
VDPLAPDSLLSSASVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RALNTTYG-----------EVSGNSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
VLPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALHGPVFSRNPEGSRTLSASRGK-ESRTLPCRQPCSSQPV-ATRSYSCHSSTLLCCRGG
DLGKEPFKAALRTVYPPCGVPSRVYEMDETGETSSRGPDVLLTHGL----EPKDVNREFG
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--TELEATSFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVENKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHDC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDIR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPVTAIFSGPERS-KSSPTPQISVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKSMA------RTSLRAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QGQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRPEEHARIGWKQYVFGSTVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPLHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSVSLGDPHILTSSEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPPL--AEGSAAG
PADEIMLPYPSGAGCPVGQ-TRMNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAT
AASAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASP----------TLRLQ-ASEAEPQGANV-ILEGLGS-
---HTSTLS----------QEEGDVPGVAQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEESSCIAV
SSPSP----SPCHSPGLLPST-SEYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG-A--PRTP-MDNYSQTT
DELGGS---QRG-------GSVL----QRS-----NGRSFLELHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPSTTIGVQS-------------------RLLP
PPLRHR----SQTLADSFVPEEVAS-PERGPLSGKEP---SQWRSRTENGGESSASPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKG----MDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKELFVWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVS--QLL-----REEDKLHTLATSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQAPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVSN---------------CSCPYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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----LTVELAEAKLNYGIGETDALLRVLQRGAADEPGA----IPVKQ--QLYERH-----
----------MRTIETLRKERVKRLQRYQRSRSLSPQKHLSLSQTLDGSQRDLDLPSRRR
EYLQQLRKDVVENTRAQEPKRR-SVQHPSDIELLLQDYQRAREETKTEIARARDKLRERA
EQEKRRIREQIFSQLQK-------EEARLKTLASTSTLCTD-SSLSLSSGPTSGYNSSNT
-ATYTASEKPVLGETDVPWNRDECLGKGCYHSFIRI-TWIGG--------------SSGE
FK-IQPPLPSSGT------SCRF-------THG--------LTIS----VNSSSTKGYQD
LSKHILANATTEVMAACSHNLRNLYT

PF01852 // ENSGT00890000139327_7_Domain_2 (5607, 5802)

CQAAAGWKYQCTEKEV---------QVYYKVFPS
-ATRHGFLG--AGVIERPLPYVWGLVRDPGKRHLYDSSINIARIHKKVTSHIHLVYLVTD
TSLCYLKQPRDFCCITVEAKE------ENLSVLAIQSVYDASMPQPCKEAVRGEILPSAW
ILEPDIVNGREITRVIYMAQVDLAAPAIPARLLSSVAKQQPLVIAQLAQLLTA

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQSWISQQIKENQQCLLREETWLASLQQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPRPQ-CRSKLTSCSSLSP--
QRLC---SKHVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRIGCLRKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLRKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASGNS---------PYPHGPRQTAGHGKAVK
TFW--TEYKPPSLSRASKRHQR--VLAARVRNITKKSSHLPLGSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYTKA-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRARASVRGFIA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPFPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKCLLELSHPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGEGGDTSLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPGSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SQ-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNRQALQDAYLKNNLPVLLQNQNSKVASSQ-QVTA---EIPVDLNTGEVI
RESGKCPGNIT-E-----ESR----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPGMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
KGPGN-SQE----MLNP--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
ATVFR--DSEAGEI--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPVREHTH--
PAGSDRLARDIF--ES--------------LGKHTTCRA-----FTNTSFRPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KGFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RRRSLQEENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVHH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGTEDKISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEKETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSLEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECPSGVAGGPQCKQIE-----------LSSSDQTRNEGEAPGFHVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPNTETDRQ------------
-PWDPMQAFSHAAP--ALDKKHCAGEL-RQFAGTSEPFICHSGSFEILEKKKDATRTPSS
VDPLAPDSLLSSAPVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RALNTTYG-----------EVSGNSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
VLPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALHGPVFSRNPEGSRTLSASRGK-ESRTLPCRQPCSSQPV-ATRSYSCHSSTLLCCRGG
DLGKEPFKAALRTVYPPCGVPSRAYEMDETGETSSRGPDVLLTHGL----EPRDVNREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--TELEATSFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVESKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHDC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDTR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPMTAIFSGPERS-KSSPTPQISVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKSMA------RTSLQAEDSNQKASSHLD----DGITD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QGQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRPEEHARIGWKQYVFGSTVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPLHSHLSTYANILDLSTTHSSTENAQGSNEAWEV
FPGSSSVSLGDPHILTSSEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPPL--AEGSAAG
PADEIMLPYPSGAGCPVGQ-TRMNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAT
AASAS-DLASWTSMHTLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLTSP----------TLRLQ-ASEAEPQGANV-ILEGLGS-
---HTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LMYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPLR--QHLPSMGPSVSDAF-LPPSSQPEESSCIAV
SSPSP----SPCHSPGLLPST-SEYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSVL----QRS-----NGRSFLELHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPSTTIGVQS-------------------RLLP
PPLRHR----SQMLADSFVPEEVAS-LERGPLSGREP---SQWRSRTENGGESSASPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKGSPGGVDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPSKELFVWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVSQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQSPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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----------------------------------------------------------VT
EELGASCDLSE-GEQ-GQSTPHP---------LEGQSQGPEWSQR------EQIPLQVGT
QNLSLSMELTEAKLHRGFGESDALLQVLQSGAGEALAPDKPALSTWE--ELHARQ-----
----------KTTIENLRRERAERLQNFHRTRSLSPQKQLTLLPNRDFPIQDLDFPSRRR
EYLQQLRKDVVETTRSPESVSR-PVHSPLDIELMLQDYQRAREEAKAEIARARDQLRERV
EQEKLRIRQQITS--QLL-----REEEKLHSLANSSSLCTS-SNGSLSSGVTSGYNSSPA
-LSGQLQSPENVE-Y------------------LSLVDS--KDTWIEDGQGLSTSAQ---
-------KSSAY-----SRRVSLGS--CCCS--------PISQSSLGTSY---T--SYQD
LAKHIVDTSMADVMAACSDNLHNLFSGQAAAGWNHQGEEQAV---------QLYFKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPTLWPLYHKPIQTVRLYQRVTNNINLVYLLCN
TTLCALKQPRDFCCVCVEAKE------GPLSIMAAQSVYDTSMPRPSQKVVRGEILPSAW
ILQPVTMEGKESTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSVILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLSDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGR--GSLEWLDLDGDLAASRLG
LSPLLWK-ERRALEEQCDEDHQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIRAEK
ELEFDQAWISQQIKENQQCLLREETWLASLQQQQ-QE---DQVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVHLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDA--TVPRPR-CRSKLTSCSSLSP--
QRLC---SKHMPQLHS-------------IFLSWDPSTTLPPRPDPTH----QTSEKTSS
EEHLPQAASYPARTGCLRKNGL-HSSGHGQPCTARAALARKGASAPDACLTISPNS----
-VGIQEMEMGVKQPHQMVSQGLASLRKSANKLKPRHE-PKIFTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHKAA------KGASCNS---------LYPHGPRQTPGHGKAVK
TFW--TEYKPPSPSRASKRHQR--VLATRVRNITKKSSHLPLGSPLKRQQNTRDPDTMVP
PTDFSPVMDHSREKNNDLSDTDSNYSVDSLSCVYAKA-LIEPLKPE---ERKWDFPEPEN
SESDDSQLSEDSLAEKRYQSPKNRLGGNHPTNNRG----QPRTRTRASVRGFTA-ASDSD
LLAQTHRSFSLDSLIDAEE--ELGEDQQEEPFPGSADEIPTETFWHLEDSSLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAES
QVEPSYSEQADSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFHPCKGERPGYWPNTEELKPSDAETVL-PYSSKLHQGSTELLCSARDE------H----
-----------TAS-AADTSRLSLWGIQRLI---QPG-----ADGTF--QGRCIPDMTQQ
GSSEASHNSSVSNVLAASATTL---THVGSTHERDW------SALQQKYLLELSCPVLEA
IGAPKP-----AYPYLEEDS--GSLAQASSKGGDTLLPVGPRVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETYS----ADLESLSASRSTN--AQVFA
AENAMPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEDFFQKNACHSNVT-T
ATKADHWSQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINVS-
--FALPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQ-QVTA---EIPVDLNTREVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVVILNKKHSF-PALEG---GE-VT-A------QSCCSASSDSTES-----
-------------GKSL-LFRESEAQEEEEL----------------------------D
QNTVLRQTINVSLEKDMP--GESA----VSLKSRSVDRRVSSPVMVAQDGGPTPKW----
EGKNETGLLEKGLRPKDSSEEFKLPGTKP-------AYER--FQLVACPQ-ERNP--SEC
K-----SQE----MLNP--NREPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGTDKELVFQDQ-KEQEKTDHAFR---PDSSGNPLPSKDQPSSPRQTD
DTVFR--DSEAGAM--EVNS-TG-NHPQVQKITP----NPFRSREGVRESEPVREHTH--
PAGSDRTARDIC--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALARALPLQPRLERSSKNNG-QFVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQVAEHVSSS--------------NQEEPKAQGKVEEMPMQ
RGGSLQEENK----VTQKFPSLSQ-LCRDTFFRQETVSPLLSRTEFC-TAPLHQDL-SNT
LPLNSPRWPRTCLHVPV-ALGISSLD---CVLDLTMLKIHNSP-LVTGVEH-QDQSTETR
SHSPEG-NVR-----------------------------------GRSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--IPLGTEDRISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIR-VSSLNKVSSQPEKRVSFSLEEDNDQASK-PRQK---AEKETEDV--
--GL----------------TSGVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDHASMCL-----AILEE----------IRQAKAQRKQLHDLVARG
TVLSYCETLLEPECSSRVAGRPQCKQID-----------QSSSDQTRNEGEAPGFHVASL
SAEAGQIDLLPDERK--VQA--------TSL-SADSFQSLPNTETDRE------------
-PWDPVQAFSHAAP--AQDRKHRTGEL-RQFAGASEPFICHSSSSEIIEKKKDATRTPSS
ADPLAPDSLRSSAPVEE--VRRVVSK-----------------------------KV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPPGSQDSSPEHQEP--RTLDTTYG-----------EVSDNLLVTAQG-
EK----------TAHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGR-ASPKQDT
ILPGALTRVAL-----EAPTQQCVQCKESVGSGLTEV-CR--------------------
AGSKHSR--PI------------------------PLPDQRPSANPEGIGEE-APCRHPR
EALDGPVFSRNPEGSRTLSPSRGK-ESRTLPCRQPCSSQPV-ATHAYSSHSSTLLCFRDG
DLGKEPFKAAPHTVHPPCVVPSRAYEMDETGEISSRGPDVHLTHGL----EPKDVNREFR
LTESSTCEPSTVAAVLSRAQGCRSPSA-PDVR-TGSFSHSATDGSVGLIGVPEKKVA---
---EKQAS--TELEAASFPACMYSEPLRHFRDSSVGDQNAQVCQ-TNPEPP--ATTQGPH
TPDLSEGSAESKLVAE-PQHECLENT-TRCFLEKPKFSTELRDHNR-LDSQAKFVARLKH
TCSP--QED-SPWQEEEQHRDQAS-GGGEGFAQGVN-----PLP-DE-DGLDGCQILDAG
RE-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETSQPAAQRTG-H
LYTGREQPA-------LPVTTIFSGPKHS-RSSPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNPHLRGYSSGKSVA------RTSLQAEDSNQKASSCLD----DGTTD
HRHLKPATPPY---PMPSTLSH-------MPTP---DFTTSWMSGTLE--QAQQ-GKREK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRPEEPARISWKQYMSGSAVDVSCSQK
PQGLTLSNVARCSS--MDNGLEDQNSPFHSHLSTYANICDLSTTHSSTENAQGSNEAWEV
FRGSSSIALGDPHIPTSPEGVAPTSG-HDRMPQFRGPSGEAD-CLRSKPPL--AEGSAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFEQGTQTLG-NR-------RHWSSTDISFAQPEAS
AVSAF-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLTLP----------TLCLQ-TSEAEPQGANV-ILEGLGS-
---DTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQSPSIP-SSHLRFQKAPVG--QHLPSVSPLVSDAF-LPPSSQPEESHCLVV
SSPSP----SSPHSPGLFPST-FEYPGDS--RVQKKL-GPTSALLVDRASSPILTLSAST
QEPGL-SPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVD-A--PRTP-MDNYSQTT
DELGGS---QRG-------RSSL----QRS-----NGRSFLELHSPHSPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTIGVQS-------------------RLLP
PPLRHR----SQRLGNSFVPEKVAS-PEHCPLSGREP---SQWQSRTENGGESSASPGEP
Q-CTLDRPS-SWGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEELLCF---SCQMCMAPEHQHHSLRDLPVHNKFSNWCGVQKGSPGVLDMTE
EELGASGDLSS-EKQ-EQSPPQP---------PNDHSQDSEWSKR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGETDALLQVLQSGTGEALAADEPVTPTWK--ELYARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERT
EQEKLRIHQQIIS--QLL-----KEEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQFPENMG-H------------------RNLPDS--RDVWIGDERGGHSAVR---
-------KNSAY-----SRRASLGS--CCCS--------PSSLSSLGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSRVWAAVSDPTLWPLYYKPIQTARLHQRVTDSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKREIKEGGRIIVEVDGNVAKIRNLKVDSRPDGFGDFREKIVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPT
SVGLTP-RICE-----------------------------GLFIREEDYAPLPSSCRIKV
SFLEIYNERVRDLLKQSDKKKSYSLRVREHPELGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHIHEASSRSHAIFTIYYTQAVLENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQAFSSCQSLNSAA-SD-GDSGIPSSPSGTSSG
AGPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KH

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIRRLKAMLLNFELRNF-SPLNEEKDENLKELVLQNELK
IDHLTKDWTQKWNEWKALVENYRVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVILRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAVGGS--GSLEWLDLDGDVTTSRLG
ISPLLWK-KRRVLEELSDEDHQPLRAGEAPHRAQIQ--Q-QHYVGDLRQRILAGQIRAKQ
DLELDQAHISRQIKDNQQWLLGDEIWLTGLQQ-------QDHVAEK--------ELKACV
PSGAWLQTDSETQLSPLVRSQ-KREVRLRLGCRNALRVAQRDIRRRKAS--FQLERI-KK
QRLLESQKGLEPSKASCWLQDDCTQKPPYWVPSTDA--MLPGPQ-HRSRLPGCSSLSL--
RGLC---SWYFP-------------QLHSIFLNRDPST----MPDPTD----QISEKIPS
EEYFPQAAAYPPRTGHFSKNAH-CSSGRGPLCTARGALARKGASVSGTCLTVSSES----
-ASIQEMERAGKQPCRMVSQSLASLDHSVNKLKPRDNKPVALTPSTYIRWGRGLADS---
-DHTRAEWQKEE-NLGTHKTA------KGACCSS---------SQPCGPKQASGHGKAAE
IFW--VESKPPSQSRASKRQQR--VL---VKDIVKKSSCLPHGSPLRRQYHVGDPDSTSS
LTDSSPRVDHIRDRNGDLSDTNSRYSVDSLSCVYAKA-LMEPLKPEDPQGKEQGLPEPEN
SESDDSQISEDSLAEKGYESPPDNPGSSYLPSGHG----HPRTRVMASVRGFTT-SSNSG
LFTQTHRSFSLDSLIDAKE--ELREEQQEEGFFSSADEMPTETFWHLQTSSLPIVEQ--E
AMCRLGPISNGTV-ARLDAILPMSSSFYLGPPPQP------------------PCEQPES
EVEASSSEQTNMLQG-LQLSRGS---PLLSMDSWFSCDSKINSSSPSGIVGSLCPSPDVQ
ESQPHGWERPGHGQNIEELKPSGAEILL-PYTSKLPQGGTELPCCVRGV------Y----
-----------TIP-ASDTSKLSFWGSHRLL---QPR-----VAGIF--QARGIPDTAQE
GNSEASNNSSVSSVLAASAASF---THVGSTHERDW------GALQQKYLPELSHPVLEA
IRESRP-----TFSSLEEDS--ASLTQGSGKETDTLLPVGSGVSSSLDFSNFPVHLSKIQ
CLRAEKEQDSLSAELEGTSDFFTIREKEVSHSGTYS----ADVESLT-SGTTNV-VPVFA
AESKMANSMR-----EVCQVKQNNLEE-SSQSS-GKPQRMSSSDECFFLKSPCHSNIT-I
VSKENHWPQGWAPPMKNSAAQEGQLSHP--GY-PPLQEEKVDYQESSR-EVVRRHPSVS-
--FAFLSGPKMYPHSGAWNPLPSS-LQPPPLETFYVTKSRDALTETALEIPACRESRVPS
PSPREAWGFGHDHQVLQNIYFKNNFPVLLQNQNSKTASSQ-QVTA---GRPVDLNTKEVS
RERGKCPGNIE-E-----ESH----------------------NSVYFFVAQNKHFLSST
STKVCEFENQVGILNNH-NLSALKER---EK-AT-V------QSCFNVCSSHSRS-----
-------------RKP-LLVCESEADGEEEQDH-------NVVLRQTQALDMNRQFPSGA
RSDFIYETINLALDNDML--GEAA----ISLQSRSVHHRVSGPKIMAPDESPAHKG----
ERKNESGLLGKAFHPKDSSKEFKHPKTES-------IYER--FQSVTCSQ-EKNL--NES
KGPGR-SEE----MLSP--KEEPSGKKQNKRVN--SGDEMARLIRSVIQ--LEDGILEIE
SKQNKQLSASQTLGVGKEFVFWDQ-RDQEMADYVLR---PSSFGNYVSLKDQPSSPKQTD
DVTFR--DSEAREM--EVDSSTGEGLQ-AQKITL----SPFRSRECIQDTKFAKEDTCP-
-AVLNRSSRDTC--DY--------------VRTCTVCRE-----FTDTCAN-PR------
------------TKALASALPLQPSPKMSSEKES-EAENA-----S--ASP-PTRQPCGL
GSLEELETV-----KDFWETQVAKCISSS--------------KQEEPKVQGRVEEMAVR
RGGNLQEENT-VVSLIQQLPSPSQ-CCIGTSSSQEI-GPLLSQPDFS--EAPHGNL-HSS
LPLNSPRLPRDCLHVHD-TVGISSVD---YVLDPTILKIPNSP-LVTGAES-QDLCGEPQ
SHSPQG-TIR-----------------------------------EGSSSAHSAWCGSVI
ST-------SMRSHGQFCVSEN--IPLGAEGKRSV--ST-QDQGGDLRSILMGLSSRDGF
ASEAEAAVQRGTERATSLNRASSPLEKKASCLLEEGNSQGCP---------AEEAEDL--
--YL----------------PSGTFSAPVSLP----------------------------
-RMPLPERCA------HTSMGL-----GVLEE----------ITQAQAEGKQLHDLGAGG
NILPYYETLLGPECSSGVT--------D-----------QSLSDRTRNEAEAQRFHVASL
SAEPGHL--LTNERK-VSQA--------TPL-PADSFQHLPSTETHIV------------
-PQPTSQISSHVAP--TLGKSYCSGEL-RLFLGAGEQLVCHSSSSGIIEKKKKATTTPSS
ADPESS-GNFPSV-AVE--DRREIPE-----------------------------KV---
----------------------------------VAALPSWTPLNDPGMIPH-----RGS
HS-ALQATIEATLPGGQESSPAHQEP--RILDTTYG-----------GSSGNVLVAAKG-
GK----------TTCFESQLVTCDVQNSVSLSGCIQDYAPCLEAFTGLEEGR-ASPKQGT
NLPRALRRVEL-----EAPSQQRVKRKESVGCGLAET-CH--------------------
GGSKHSR--LT------------------------SLPDQRPSPSPGGVQEE-AQCRCPR
EASYCVVFLGNIEHSRTLSLSRGQEDNR-TTPCHLCNPKPI-ASLISFSPLSTLPGYRDG
DLGKESSKAALHTLQPPCIMPSRISGMDERGESCSRELEGLLAPGL----EPKVIHREFG
PTDSSTQEPSASAAVLSLVQGVSSPSA-PGMR-TSSLSHSVADGSSRSVEDPEKEVA---
---EKKPS--TELETAFSSADMCSEPLRKFQGSSVGGQNTQESQ-TKPELP--LTVERPH
TLNLSEGSVESELPGE-PQHGCLGNV-IQHLPEKPQLSTEFRDHSG-LGPQAKFVAKLKH
ISRH--QAD-GPWEEEGQQRDQAL-SGSKEPAQDRS-----SQPSHE-GGLDGCQIRDAG
TE-----------------EASTAKSFVSKMFLTGFEDSATMPLGQSGAPRLTPQSPG-L
PASGREQPAP-HHRCSLPVIAVFSGPKH-SRSSPRPQFSVVSSSRSLQELNLS-VEPPSP
TDEDI-QEPNRLWSPHHRDYFSDESAV------RTSLKAEGCSQKASSNAD----NRTDN
HWPPKPTTLPY---PRSSALSC-------MPTP---DFMASWTPRTLE--ESWQ-ENLER
PGSQARPEKWHSE-ADKKMLHFDSSDINPYILSSHPERPVQIGWKQYVFGSALDVSCGQT
PQGLIPSNKTRCSS--MDKGLEHQNSPLYSHLSTHANARDLSSTHSSIGNAQGSCEAWGV
WG--SSFALGNLHILNSPEGATPSKG-ADKRAQFWDTPDEVG-CLRNDPLL--AEGSAAS
PVDEIMLLYPSEVGGPVGQ-SRINTLEQGTQTLG-CS-------LHWSSTDIS-AQPETR
AVPVS-GLVSWTSMHNLSLHLSQLLHSTSELLGSLSQPSVAEKEQNIK--RETPDEVTQ-
-ALMIDGYTQTTMDKGIQTDLAFP----------PLHLQ-APEAGPQEVSG-VLEVLGS-
---DIPIMFP---------QERGHVTHNLQKRET-EEMTSK-MAR-----PSELQ-----
-EESTHCRPQSLPAST-SHVRFQKAHFG--QNLPSVSPQAFPDASLPPSSQPEVPSCLAV
GSPSL----SSSQSPEPCLSA-AESVRDP--QVEKGL-GTIGTLLVDRASSPILTLSAST
QRLGFPS-DSLSLTVPSA----CPPEGHQKLV-SS---PDLLL---DTSRFPVVNNPQTT
DESGGS---QRVGALCGEGRSPL----ERS-----DGRPFLKISSPDGLPQ---------
-----------SPKLQVCLLEQPPQQLQPRTTTL----------IQS---------GLPP
PSLRSQ----SQRLANGLVPDDLAS-LECDPVSSRGP---SRWQSKTEHGDESSASPVEP
Q-PTLDFLS-SRED--L--------QPLIP--CPVSGLTEGSVH----RALSTGL-QGSA
LGPTEACQTEMLLCS---GSQVCVAPEPQHHSLRDFPVHNRYTHWCGVQDGSPVGLGLME
-SLGPRCDLSS-GEQGQ-KPLQP---------PDDQSQGPHWSQR------EQIPLQVGA
QNLSLSMELTEAKLHHGFGEADALLQVLQSGTGEALSAEEPVRSTWE--ELYARQ-----
----------KQTIETLRRERAERLQNLHWMQ-IRPRKQLSLLPNRDLPTRDLDLPSRRR
EYLQQLRKDVVETTRSPGSASR-SAHPASDIAVMLQEYQRAREEAKVEIALARDRLRERT
EQEKLRIRQQIISQLLK-------EEEKLHTLAMSNSLSTS-SNGSLSSGVTSGYNSSTA
-LPDQLQSPDSVG-D------------------INLLDC--SDSWIGDVRGSSTVRTSHL
SLAGSAWKSLAS-----GPRTSLGS--GCCS--------PSSLSSLGACF---SS-SYQD
LAKHIVDLSIADVMAACSDNLHNLFSCQAAAGWNYQGEEQEV---------RLYYKMFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNSINLVYLVCD
TTLCALKQPRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEITRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGC

--MANVRVAL

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 327)

RVRPLSKRETKEGGKIIVEVDGKMAKIRNLKXXXXXXXXXXXXXXXXXXX
XXYCYWSVNPADPHYASQDVVFQDLGTEVLSGAARGYNICLFAYGQTGSGKTYTMLGTPX
XXXXXXXXXXX-----------------------------XX-XXXXXXXXXXXXXXXXX
XFLEIYNERVRDLLKQSDQKKSYTLRVTEHPEMGPYVQGLSQHVVTNYEQVIQLLEEGIA
N--RMTAATHVHEASSRSHAIFTIHYTQATMENNLPSETASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISAL-GILW--------------------------------
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--MAGVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGKIIVEIDDKVAKIRNLKVDSRPDSFGDSREKVVAFS
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAEGYNICLFAYGQTGSGKTYTMLGTP-
----------------------------------------GLFIREEDCASLLSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYSQAIVENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQAFSSCQGLSSPA-SSSCGDNETPGAPGTSSG
RGPSRRQAYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIRRLKAMLLSFELM------------------------
-NKLTKDWTQKWHDWQALVEHYRVDISRRRAGVVIDSSLPHLMALEDDVLSTGVALYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPAQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5659)

GKAQKFRFSHPAEAAVLRRR-RQVGEAIGSS--GSLEWLDLDADVTASRLG
LCPFLWK-ERRVLEEQSEEDHHPPRNGETSHRAQIQ--QQQCCVEELRQQIQAEQISAKK
ELEFDQTCTHQKIGDNQQWRFREDTWLAKLQKQQQQQQEDDLGAEK--------ESEVSV
APDARLQTYSEAVLCPLVQNKKNRLVQLQLPQRRAPQAGEHNIPRKKAS--LQVDGFIKK
QRLLEAQESLEQLRELCWLQDDSTHQSPCWVPTSDS--TAPEPP-PRNRRTSCSSLSY--
QRL-------LP-------------PLHSAFLNGGHSTMLPPMPDPTH----QVSEKIPL
ADHVSPAAACLPRMGCLYNSDL-CPSGQPQLYT----------SALGTCLTLSHKS----
-VNIQEVERMGKQLSQMVSQGLS-----PDNLKSRDG-PKTL-----TSGTQRLADS---
-GNTQAVSQKGR-NLGAHKAA------RGASYSY---------SYPGGPKQAAELGRVAN
TFR--TESKLPFPGRESKRLQR--VLAAKVRDIAKKYSPLPHGRPLKGLHSAGDPNTTAS
HTDSSPVMDCARGE-DDLSDTDSSYSVDSLSCVYAKA-SLTEPLTPEDLPGKWYLPASEN
SESHNSQISEELLVEKGDQSSKERLGGSHPPNKCS----HLKTRTKTCMRNFPR-PLDSS
LLA---ESFSLDSLIDQ-----------EEPCLGSADEMPTEIFWHRQNSILPVVDQ--E
AMCRPGPISHRAG-TGLSAILPVSSSFYLNPQVQP------------------DKEQSES
EMEASYPERASSFQG-IQLSRES---SLVSMDSWFSCDSKINPSSPGGVQDSLLLSPDVQ
EVQPYDEEKPGCLRSIKEL------------NLKLPQGNTELACTARDV------H----
-----------TTS-ASDISKLSLRGTQRLL---QPG-----ADDLF--QGRA-SDTTQQ
GNSEVSNS-SVSSGPAASATSF---TYVGSTHEEDW------ATLQQKFILELSHPVSEA
IREPRP-----PFLYLEEDS--SSLAENSSKGGDTQQQVGSGISSSLNFNDFPVHLSKTS
HLRAEKEQDSLSATLESASDFLSTSEKEVGCNGAYS----ADLESLA-SGFTN--IQVCV
AENKITYSLK-----EACEVRQKSLEG-CYQDS-RKTAVITSSDTY--------------
ATNADHWPQGQSPLRKNSSVQRGQLSHN--NH-HFQQKKKADYQESSE-EVVGRHTDVS-
--FASLSDPEPHVRCAPWNPFSSS-PQPPILETFYVTKSRDALTETALEIPARREVWVPS
PPPREAWGFSHDHQVLQKTYL-NSLPVLLQNRNSKVAFSQ-QVTA---ERPVDLNTKEVT
GKLGECAENTK-E-----GSH----------------------NSVHFLVAQNRHIFSFT
GTEVPEHENEFGILNKKHSLPVLNEK---EK-AP-T------QPCWDVFSDSSGS-----
-------------GKPFLFICEPEAGRKEEQA-------------QIQAHDMSRQIPFGP
RSDFICKTTDLGLEKDMP--GETA----VFMKSGSVCHGVSSPMIIAQDESPTHKW----
GEKSETGLLGGTVHPTDSPAEPELSEIGS-------TCES--APSVTCYQ-ESCP--IKC
QGPRG-SQE----MLNS--KDEFLGKKQYKGVS--NADEMARLIRSVMQ--LENGILEIG
SKQNKQLHASHTSGVSEEVVSQDQ-KDQESSDHVLR---PGSSGNHLSYKDQSSFPRQAG
DVVFG--DSEAGEM--EANRTTGNENQ-VQKIPP----GPSRSRECVQQCQRVVAHTRP-
-AGADSASRDTC--D---------------LGKGAACKE-----PTDTALHQRR------
------------MKALSRAPSLHPWPESSGKEVR--LVQA-----S--AS--FEEQPWGL
GNLEDLETM-----EVFQDSQVAECISDS--------------KPDGLRAQSEVEEMALH
LGRGPKDKSN-MVSLTQEHPGPNQ-HCTCTCFSQET-VSLPSHTDFS-TAPSNQDW-SNT
LPLPSPRLPGSCFHGPD-IIGISSVD---HVLDPTILKIPDSP-LEHGVGC-DSQSRENR
SPHLQG-DIR-----------------------------------RGSSMAYTAWCGDVR
PM-------ALGLHGQSDAAEN--VPLGTEEQITA--ST-SQDRGDLEITSLGLTAQESF
GNETEAAGQKEIQ-ATSSNMTSRELEKQVSLSLEEGNDQGRG-AKCK---TQEEAKDQ--
--GP----------------VSRTCSGSVSMP----------------------------
-KVPDPEPILLE-TSVHASICL-----AILEE----------IRQANIWRKWPNDFGTGG
TVLTDYEPSVEPERSSGAAGRTQCEQMD-----------QLMPGRTRSEGEAPECHVASV
FATPGHL--LADERK-A-QA--------MPV-CIDGSGPLPSPEMNRG------------
-LQLPPQSSSHAAP--APGKRCYPRDL-RLFQEAKEGFSDHSGSPGIIAKKKQASRTFSS
A---------------------VGSE-----------------------------KA---
----------------------------------VSALS---SYDDPGPVLC-----GQN
QL-ATRDTVEGMSPGSRTGSPEHREP--EAVDTTYG-----------AVSGNFSVTAQG-
GK----------TAHFESQSVSCSVGNSSSSSATKQDQVQCHKASTGLEEVR-ASPKQQA
ALPGAPRNAEV-----EAGAQQ--------------------------------------
-GNKNLS--PT------------------------PSPDPR--------GDE-APC----
--GDCIVFSGSTEGSSARSTVREAKESGTIPCQQSCYHQTT-ATR---------TCQRDG
DWQ-TNSQAAPYPVYPPFIAPSRAHEMSEIGKTSFKEADILLAHSC----G------TLG
PADGSMVEPLTAAAIRSPTQGCNSLGT-SYVR-THSLSESATDRSLRTVGGPEEEVA---
---KKKAS--TELEAAPCPAGTCSEPLRNLRDHSVGGHSAQVSQ-TKPEPP--TETQGPH
TLRLSEGSLESE-------HGCLENT--KRLSEKPNPSTECRD------PLAKCVA--KH
ICSP--QGD-SPWEDQEQQRDSAS-VGGEALPQGRN-----PPLDDQ-GGLNGYHIRGV-
---------------------AVTTFPVSQSFLPGFGDPASVEV-----PQPVGWRPG-R
LYPSEEQPTP-HHGPSLPVITVFSGSKH-CMPHPRPQFSVVN-SQSLQELHMR-VEPPPP
PDEDA-QGLHRLWHPHIRDCSSGKMVT------ETPLKTEDSNPSAPSNLS----DGPAE
HMPLKHATPPY---PVSSTVSS-------MPTS---DFMNSWVSSTLA----LQ-RKPEK
LGVQVRSEDG--Q-VEKGMLYLGSKDINRYISPWCPEGPVHIGWKQCVFDRAADVSCSLK
AHGPRPSNVAQCSS--MDNVLGDQNPPFYSHLSTYSQTQDLSSTHSSTENVQDSNE----
----------------------------------------------SGLPL--AEGSSVG
AVDEVVLLYPSETGSPVAQ-AKVNTYEQGTQTLG-CQ-------LPQSCVDVLPAQPDTS
EVSPC-DLASWASMHNLSLHLSQLLL---------SQPSVA-KEHNTK--RDPIAEALQ-
-ALRTDRATQTSVEKDSQAELASP----------SLHPQ-APEAKTQEVSV-IVEVLSS-
---DTASVS----------QEKGDVTGALESD-T-EEMARK-ATV-----PSDLL-----
-EESTPCALGSPPQK------------------PSLSPPASLDA-----SQPGDSCCVVV
HSPGL----STSRTPGPSPSA-SEPTREP--QVQRKP-GPMSACLVDRASSPILTLSAST
QEPGPTP-GILTLSAPSA----CPPEGHQKLD-FS-------------LRPPADSCSQIT
HEPGGS---QTLKALDGKG----------S-----SGKSVLELSCPCSPPQ---------
-----------SLSVQVSFLGQPVQQPEPRTITG----------GQS---------SPPV
PPSRYW----SQRLTDSFLSEEAAS-PEQGPLS-------SQWQSRPENWGECSAPPVEP
Q-LAANPSS-W-KG--S--------QHLGP--SPGAELTD-----------PAGM-RGCT
AGLPQVCQLEE-MCP---SSQICVAPEPQHCSLRELPVHNKFSNWYRVQHGSSRGLGVSK
-ELEVSSDLCS-GEQKQ-MLPQP----------GDRSVHPEWSPR------EQVSLQVGA
QSTPLSIELTEAKLHRGFGEADALLQVLQRGTGAALAPDEAVGESV---MFCLRQ-----
----------KQVIETLKREQAERLHTFRRTRSLSPQKQLSLLPNRAFPSWDLDLPSKRR
EYLQQLRKDVVETTRSPESALS-SAHPPTDMEQMLRNYQQAREEAKVEIARARKRLRERT
TQEKLRIRQQIISQLLR-------EEEKLHALASSSSLCTS-SNGSLSSGVTSGYNSSPA
-LAGQLPSPESVV-S------------------GQGPGLLRQETWRDP---WTSTRNSNL
YLAGSAPKSTDC------SKGFLGS--CCCA--------PSSLSSLGTCF---SS-SYQD
LAQHIVDTSMADVMAACSDNLHNLFSRQATAGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--AGVVAQP

PF01852 // ENSGT00890000139327_7_Domain_2 (5659, 5804)

LSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNSISLVYLVCS
ASLCALKQPRDFCCVCVEAKE------GHLCVLAAQSVYDTSMPRPRREMVRGEILPSAW
ILQPVTVEGKEITRVIYLAQVELGAPGFPPHVLSSFIKQQPLIVARLASFLGS

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--------------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (87, 403)

TEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRQEDCAPLPSSCRIKV
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFS-CQSFNSAA-SNGGDSGVPSSPSGTSSG
GGPSRRRSYIPYRDSVLTWLLKDSLGGNSRTIMVASEGMPELVL-----CWDWCSASEKG
PW----------------------------------------------------------
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----------------------------------MTKVQVSCLWLER--VPQLRQ-----
----------KKTIEILRRERAERLHHFRRTRSLSPQKQFGFLSSKDLPIWELDLPSRRR
EYLQQLRKDIVETTRIPELASR-SARPLSDIELMLQDYHQAREEAKVEIAQAQDRLRERT
EQEKLRIRQQIISQLLK-------EEEKLQTLANSSSLCTS-SDGSLSSGITSGYNSSPA
-FSGHLQSPEVKE-D------------------TQVPDF--QDTWTGDWRGRSTVRNSQL
YLTGSAWKSLAY-----SRRASLGS--GGCS--------PSSLSSLGTSF---FS-LYQD
LAKHIVNTSMADVMAACSDNLHNLFSRQATAGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG-

PF01852 // ENSGT00890000139327_7_Domain_2 (5651, 5806)

-AGVVSQPLSHVWAAVSDPTLWPLYHKPIHTARLHQRVSNSISLVYLVCD
TTMCALKQLRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPSRKMVRGEILPSAW
VLQPAIMEGKEITRVIFLAQVELGAPGFPPHLLSSFTKQQPLVVARLASFLGS

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANLKLIRELREEIERLKALLLSFELRNF-SSLSD---ENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGR--GSLEWLDLDGDLAASRLG
LSPLLWK-ERRALEEQCDEDHQTPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIRAAK
ELEFDQAWISQQIKENQQCLLREETWLASLQQQQ-QE---DQVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVHLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDA--TVPRPP-CRSKLTSCSSLSP--
QRLC---SKHMPQLHS-------------IFLSWDPSTTLPPRPDPTH----QTSEKTSS
EEHLPQAASYPARTGCLRKNGL-HSSGHGQPCTARAALARKGASAPDACLTMSPNS----
-VGIQEMEMGVKQPHQMVSQGLASLRKSANKLKPRHE-PKIFTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHKAA------KGASCNS---------LYPHGPRQTAGHGKAVK
TFW--TEYKPPSPSRASKRHQR--VLATRVRNITKKSSHLPLGSPLKRQQNTRDPDTMVP
LTDFSPVMDHSREKDNDLSDTDSNYSLDSLSCVYAKA-LIEPLKPE---ERKWDFPEPEN
SESDDSQLSEDSLAEKRYQSPKNRLGGNRPTNNRG----QPRTRTRASVRGFTA-ASDSD
LLAQTHRSFSLDSLIDAEE--ELGEDQQEEPFPGSADEIPTETFWHLEDSSLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAES
QVEPSYSEQADSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFHSCKGERPGYWPNTEELKPSDAETVL-PYSSKLHQGSTELLCSARDE------H----
-----------TAS-AADTSRLSLWGIQRLI---QPG-----ADGTF--QGRCIPDMTQQ
GSSEASHNSSVSNVLAASATTL---THVGSTHERDW------SALQQKYLLELSCPVLEA
IGAPKP-----AYPYLEEDS--GSLAQASSKGGDTLLPVGPRVSSNLNLNNFPVHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETYS----ADLESLSASRSTN--AQVFA
TENAIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEDFFQKNACHSNVT-T
ATKADHWSQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINVS-
--FALPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQ-QVTA---EIPVDLNTREVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVVILNKKHSF-PALEG---GE-VT-A------QSCCGASSDSTES-----
-------------GKSL-LFRESEAREEEEL----------------------------D
QNTVLRQTINVSLEKDMP--GESA----VSLKSRSVDRRVSSPVMVAQGGGPTPKW----
EGKNETGLLEKGLRPKDSSEEFKLPGTKP-------AYER--FQLVACPQ-ERNP--SEC
K-----SQE----MLNP--NREPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGTDKELVFQDQ-KEQEKTDHAFR---PDSSGNPLPSKDQPSSPRQTD
DTVFR--DSEAGAM--EVNS-IG-NHPQVQKITP----NPFRSREGVRESEPVREHTH--
PAGSDRPARDIC--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALARALPLQPRLERSSKNNG-QFVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQVAEHVSSS--------------NQEEPKAQGKVEEMPMQ
RGGSLQEENK----VTQKFPSLSQ-LCRDTFFRQETVSPLLSRTEFC-TAPLHQDL-SNT
LPLNSPRWPRRCLHVPV-ALGISSLD---CVLDLTMLKIHNSP-LVTGVEH-QDQSTETR
SHSPEG-NVR-----------------------------------GRSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--IPLGTEDRISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIR-VSSLNKVSSQPEKRVSFSLEEDSDQASK-PRQK---AEKETEDV--
--GL----------------TSGVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDHASMCL-----AILEE----------IRQAKAQRKQLHDFVARG
TVLSYCETLLEPECSSRVAGRPQCKQID-----------QSSSDQTRNEGEAPGFHVASL
SAEAGQIDLLPDERK--VQA--------TSL-SADSFESLPNTETDRE------------
-PWDPVQAFSHAAP--AQDRKRRTGEL-RQFAGASEPFICHSSSSEIIEKKKDATRTPSS
ADPLAPDSPRSSAPVEE--VRRVVSK-----------------------------KV---
----------------------------------VAALPSQAPYDDPRVTLH-----ELS
QS-VPQETAEGIPPGSQDSSPEHQEP--RTLDTTYG-----------EVSDNLLVTAQG-
EK----------TAHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGR-ASPKQDT
ILPGALTRVAL-----EAPTQQCVQCKESVGSGLTEV-CR--------------------
AGSKHSR--PI------------------------PLPDQRPSANPGGIGEE-APCRHPR
EALDGPVFSRNPEGSRTLSPSRGK-ESRTLPCRQPCSSQPV-ATHAYSSHSSTLLCFRDG
DLGKEPFKAAPHTIHPPCVVPSRAYEMDETGEIS-RGPDVHLTHGL----EPKDVNREFR
LTESSTCEPSTVAAVLSRAQGCRSPSA-PDVR-TGSFSHSATDGSVGLIGVPEKKVA---
---EKQAS--TELEAASFPAGMYSEPLRQFRDSSVGDQNAQVCQ-TNPEPP--ATTQGPH
TLDLSEGSAESKLVVE-PQHECLENT-TRCFLEKPQFSTELRDHNR-LDSQAKFVARLKH
TCSP--QED-SPWQEEEQHRDQAS-GGGEGFAQGVN-----PLP-DE-DGLDGCQILDAG
RE-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPAAQRSG-H
LYTGREQPAP-NHRGSLPVTTIFSGPKHS-RSSPTPQFSVVGSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNPHLRGYSSGKSVA------RTSLQAEDSNQKASSRLD----DGTTD
HRHLKPATPPY---PMPSTLSH-------MPTP---DFTTSWMSGTLE--QAQQ-GKREK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRPEEPARISWKQYMSGSAVDVSCSQK
PQGLTLSNVARCSS--MDNGLEDQNSPFHSHLSTYANICDLSTTHSSTENAQGSNEAWEV
FRGSSSIALGDPHIPTSPEGVAPTSG-HDRRPQFRGPSGEAD-CLRSKPPL--AKGSAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFEQGTQTLG-SR-------RHWSSTDISFAQPEAS
AVSAF-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLTLP----------TLCLQ-TSEAEPQGANV-ILEGLGS-
---DTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQSPSIP-SSHLRFQKAPVG--QHLPSVSPSVSDAF-LPPSSQPEESYCLVV
SSPSP----SSPHSPGLFPST-SEYPGDS--RVQKKL-GPTSALFVDRASSPILTLSAST
QEPGL-SPGSLTLSAPST----HPVEGHQKLD-SS---PDPVD-A--PRTP-MDNYSQTT
DELGGS---QRG-------RSSL----QRS-----NGRSFLELHSPHSPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTIGVQS-------------------RLLP
PPLRHR----SQRLGNSFVPEKVAS-PEHCPLSGREP---SQWQSRTENGGESSASPGEP
Q-RTLDRPS-SWGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEELLCF---SCQMCMAPEHQHHSLRDLPVHNKFSNWCGVQKGSPGGLDMTE
EELGASGDLSS-EKQ-EQSPPQP---------PNDHSQDSEWSKR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVTSTWK--ELYARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERT
EQEKLRIHQKIIS--QLL-----KEEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQFPENMG-H------------------TNLPDS--RDVWIGDERGGHSAVR---
-------KNSAY-----SHRASLGS--CCCS--------PSSLSSLGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-PTRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSRVWAAVSDPTVWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPITVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKRQPLVIARLASFLGR

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--------------------------------EKPQLSSESR------DAQAGFVARLNH
TQST--RVD-CPWEEEEQQRDQAS-GDGGNPLQGGS-----PPPSDE-DGLNGQ-IRDAR
TK-----------------EEAVPK---LERFSPDFEDSATVRLGQNGPPSPI------Q
PCSGRGQSPS-RHRGSVPVIAVFSGPKHSLRALPRPQFSMVSSSRSLQELNLS-VEPPSP
TDEDP-QGPNRLWSPHPKDCCSKELVA------STSLKAQHCSQKALSNLD----SRIAD
HGPLKPATLPY---PASSALSC-------LPTQ---DVLTSWMPGTLE--QTCE-GSSEK
PSGQTRPTEWLSG-VDKGVLHFDSSDINPYILPWRSEGPERVGWKQCVFGSAVNVSCSQT
PQGLAPSDVAPGSS--IDSGLEDQNSPFHSHLSTYANAQDLSSTRGSIENALASNEAS--
--------------------------------------------------E--VWGSATG
PVDEIPRLYPSAADHTGGQ-ARMGTLEQGTQTLD-CR-------LRPSCTDVSSAMPEAS
AMSVS-HLASWTSMHNLSLHLSQLLHSTSELLGSLSQPSAARKEQNTK--V-APGEAPQ-
-ALRMDSCTQTAVDKGSQTDLASL----------PLPLQ-VPEASNAQEANVTLEVLGS-
---DTLTMS----------PEKGAVPRALEKREA-EETAWK-TPG-----SSDLR-----
-EESIHCRPQRPLVL-PSHLRFQKDPLG--QKLPSVSPQDSPNVALASSSQQETSACLAV
SSSRL----SICHSSGLLPNT-AEATGEP--RVQKKQPGLMSALLVDRASSPILILSASA
QGSCP-VPGTLSISALSP----QPLEGHQKLD-IS---PVP---------APVDGYPQPS
DEAVDL---PGVDAHCGGGRGPW----ERS-----DERPFLELSSLSSPQH---------
-----------CPELPDGVLGQPPQQHQPRTTQAVPTWVQRS--------------TRPP
LPLRSR----SHRLAKSFVPEEVAS-PDCDPLSSRGP---APWQSRTESGSERPALLVGP
Q-PTPGNSS-PWGD--T--------RHLSP--CPVSEETD-----------TTVL-RDSA
SGPAGARQPEGLWSP---TSQTCMASEPSHHSLRDLPVHNKFTNWCVLCGDSPVGLGVTE
-ELETRCDLGS-GEQ-GERPPHA---------PEDQSQAPEWPQR------EQIPLKVGA
QNLSLSLELTEAKLHRGFGEADALLRVLQSGTGAALAAEHPMLATWE--ELHARQ-----
----------KKAIQTLRKERAERLQNFRRTPSLSRQKQLSLLPSMDFPKWELNFPSRRR
DYLQQLRKDIVETTRSSEAVPR-SAHPPSDIELMLRDYQRAREEAKVEIARARERLRERT
QQDKLRIQEQIVSQLQ-------REEEKLQTLANSSPLCTS-SNASLSSGVTSGYDSNPA
-LSGQLQSPDTLG-D------------------TDLSDS--RDAWMGDGRGRPAVRSHHL
CLAGPSWKNSAY-----GHGASLGS--GCCS--------PSSLSSSRTCF---SS-SYQD
LAKHIVDISVAD

PF01852 // ENSGT00890000139327_7_Domain_2 (5593, 5813)

VMAACSNNLHNLFIRQAAAGWSYQGEEQEV---------RLYYKVFS-
-STRHGFLG--AGVVPQPLPQVWAAVSDPTLWPLYHKPIQTAQLHQRVTNSISLVYLLCS
TALCALTQPRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPRREVVRGEILPSAW
VLQPLTLEGKEVTRVIYLAQVELGAPGLAPQLLNTFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 323)

RVRPLSKRETKEGGRIIVEIDGKVAKIRNLKVDSRPDGFGDSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRDEDYAPPPSSCRIKV
SFLEIYNERVRDLLKRSNKKKSYPLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTKAILENDLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-GIW---------------------------------
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--MANVQVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQD

PF00225 // ENSGT00890000139327_7_Domain_0 (80, 421)

VL---------------------------------------
------------------------------------------------------------
----------------------------------------SQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENSLPSEMASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGDDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLSDEKDEKLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAACG--GSLEWLDLDGDLAVSRLG
LSPLLWK-ERRALEEQCDEDHQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIRAEK
ELEFDQAWISQQIKENQQCLLREETWLASLQQQQ-QE---DQVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVHLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVLSPDA--TVPQPR-CRSKLTSCSSLSP--
QRLC---SKHMPQLHS-------------IFLSWDPSTTLPPRPDPTH----QTSEKTSS
EEHLLQAASYPARTGCLRKNGL-HSSGHGQPCTARAALSRKGASATDTCLTMSPNS----
-VGIQEMEMGVKQPHQMVSQGLASLRKSANKLKPRHE-PKIFTSTTQTRVAKGLADP---
-SHTQAGWRKEG-NLGTHKAA------KGASCNS---------LYPHGPRQTAGHGKAVK
TFW--TEYKPPSPSRASKRHQR--VLATRVRNITKKSSHLPLGSPLKRQQNRRDPDTMVP
LTDFSPVVDHSREKDNDLSDTDSNYSVDSLSCVYAKA-LIEPLKPE---ERKWDLPEPEN
SESDDSQLSEDSLAEKRYQSPKNRLGGNRPTNNRG----QPRTRTRASVRGFTA-ASDSD
LLAQTHRSFSLDSLIDAEE--ELGEDQQEEPFPGSADEIPTETFWHLDNSSLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPTSSSFYLDPQFQPHCELQPHCELQPHCELQPHCEQAES
QVEPSYSEQADSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSTPGIVGSLCPSPDMQ
EFHPCKGERPGYWPNTEELKPSDAEKVL-PYSSKLHQGSTELLCSARDG------H----
-----------TAS-AADMSRLSLWGIQRLI---QPG-----ADGTF--QGRCIPDMTQQ
GSSEASHNSSVSNVLAASATTL---SHVGSTHERDW------SALQQKYLLELSCPVLEA
IGAPKP-----AYPYLEEDS--GSLAQASSKGGDTLLPVGPGVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETYS----ADLESLSASRSTN--AQVFA
AENAIPDSMT-----EACEVKQ-NLEE-CLQSC-RKPGLMTSSDEDFFQKNACHSNVT-T
ATKADHWSQGWAPLRKNSTVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINVS-
--FALPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSH-QVTA---EIPIDLNTREVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVVILNKKHSF-PALEG---GE-VT-A------QSCCSASSDSTES-----
-------------GKSLLLFRESEAREEEEL----------------------------D
QNTVLRQTINVSLEKDMP--GESA----VSLKSRSVDRRVSSPVMVAQDGGPTPKW----
EGKNETGLREKGLHPKDSSEEFKLPGTKP-------AYER--FQLVACPQ-ERNP--SEC
K-----SQE----MLNP--NREPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGTDKKLVFQDQ-KEQEKTDHAFR---PDSSGNPLPSKDQPSSPRQTD
DTVFR--DSEAGEM--EVNS-IG-NHPQVQKITP----NPFRSREGIRESEPVREHTH--
PAGSDRPARDIY--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALARALPLQPRLERSSKNNG-QFVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQVAEHVSSS--------------NQEEPKAEGKVEEMPMQ
RGGSLQEENK----VTQKFPSLSQ-LCRDTFFSQETVSPLLSRTEFC-TAPLHQDL-SNT
LPLNSPRWPRRCLHVPV-ALGISSLD---CVLDLTMLKIHNSP-LVTGVEH-QDQSTETR
SHSPEG-NVR-----------------------------------GRSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--IPLGTEDRISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIR-VSSLNKVSSQPEKRVSFSLEEDNDQARK-PRQK---AEKETEDL--
--GL----------------TSGVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDHASMCL-----AILEE----------IRQAKAQRKQLHDFVARG
TVLSYCETLLEPECSTRVGGRPQCKQID-----------QSSSDQTRNEGEAPGFHVASL
SAEAGQIDLLPDERK--VQA--------TSL-SADSFQSLPNTETDRE------------
-PWDPVQAFSHAAP--AQDRKHRTGEL-RQFAGASEPFICHSSSSEIIEKKKDATTTPSS
ADPLAPDSPRSSAPVEE--VRRVVSK-----------------------------KV---
----------------------------------VAALSSQAPCDDLRVTLH-----ELS
QP-VPQETAEGIPPGSQDGSPEHQEP--RTLDTTYG-----------EVSDNLLVTAQG-
EK----------TAHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGR-ASPKQDT
ILPGALTRVEL-----EAPTQQCVQCKESVGSGLTEV-CR--------------------
AGSKHSR--PI------------------------PLPDQRPSANLEGIGEG-APCRHPR
EALDGPVFSRNPEGSRTLSPSRGK-ESRTLPCRQPCSSQPV-ATHAYSSHSSTLLCFRDG
GLGKKPFKAAPHTIHPPCVVPSRAYEMDETGEISSRGPDVHLTHGL----EPKDVNREFR
LTESSTCEPSTVAAVLSRAQGCRSPSA-PDVR-TSSFSHSATDGSVGLIGVPEKKVA---
---EKQAS--TELEAASFPAGMYSEPLRQFRDSSVGDQNAQVCQ-TNPGPP--ATTQGPH
TLDLSEGSAESKLVAE-PQHECLENT-TRCFLEKPQFSTELRDHNR-LDSQAKFVARLKH
TCSP--QED-SPWQEEEQHRDQAS-GGGEGFAQGVN-----PLP-DE-DGLDGCQILVAG
RE-----------------EVAVAQPPVSKILSQGFKDPATVSLRQNETPQPAAQRPG-H
LYTGREQPAP-NHRGSLPVTTIFSGPKHS-RSSPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNPHLRAYSSGKSVA------RTSLQAEDSNQKASSRLD----DGTTN
HRHLKPATPPY---PMPSTLSH-------MPTP---DFTTGWMSGTLE--LAQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWRLEEPARISWKQYVSGSAVDVACSQK
PQGLTLSNVARCSS--MDNGLEDQNSPFHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FRGSSSIALGDPHIPTSPEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPPL--AEGGAAG
PVDEIMLLYPSEAGCPVEQ-TRTNTFEQGTQTLG-SR-------RHWSSTDISFAQPEAS
AVSAF-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPDVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLTLP----------TLCLQ-TSEAEPQGANV-ILEGLGS-
---DTSTVS----------QEEGDGPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQSPSIP-SSHLRFQKAPLG--RHLPSVSPSVSDAF-LPPSSQPEESYCLVV
SSPSP----SSPHSPGLFPST-SEYPGDS--RVQKKL-GPTSVLLVDRASSPILTLSAST
QEPGL-SPGSLTLLAPSA----HPVEGHQKLD-SS---PDPVG-A--PRTP-VDNYSQTT
DELGGS---QRG-------RSSL----QRS-----NGRSFLELHSPHSPQQ---------
-----------SPKLQFSFLRQHPQQLQPRTTIGVQS-------------------RLLT
PPLRHR----NQRLGNSFVPEKVAS-PEHCPLSGREP---SQWQSRTENGGESSASPGEP
Q-RTLDRPP-SWGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEELLCS---SCQMCMAPEHQHHSLRDLPVHNKFSNWCGVQKGLPGGLDMTE
EELGASGDLSS-EKQ-EQSPPQP---------PNDHSQDSEWSKR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVTSTWK--ELYARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERT
EQEKLRIHQQIIS--QLL-----KEEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQFPENMG-H------------------TNLPDS--RDVWIGDERGGHSAVR---
-------KNSAY-----SRRASLGS--CCCS--------PSSLSSLGTCF---SS-SYRD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

NKNTQLEVSVMV-LAV

PF00225 // ENSGT00890000139327_7_Domain_0 (17, 422)

SRESAEGGRVIVEVDDKVATVRNIKADSRLDGTWDSREKTVAFS
FDYCYWSVDPEDPKYASQEMVFQDLGTSVLSGAFRGYNICLFAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFSRKDDYSDQTASCRVKV
SFLEIYNERVRDLLKQSDHKKPYTLRVREHPETGPYVQGLSQHLVTDYKQVVELLEEGIA
K--RITAATHIHNASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQMFSSCQSINTLT-SEGESSHVDSPSTG---S
VSGTRRPAYIPYRDSILTWLLKDSLGGNSKTIMIAT----SSSYNETMSTLRYASNA-KN
I

ENSGT00890000139327_7_Linker_0_1 (422, 559)

INKPRVNEDANR----------------------NS-SPSWSDDRDGNLTELVLQNEMK
IEQLTKDWTSKWMDRKAIMKEYSVDINKEKAGVTIDSSLPHLMAMDDDILSTGVVLYHL-
------------------

PF00498 // ENSGT00890000139327_7_Domain_1 (559, 610)

-RGRWIEKDHCVIDNICGIVTLRPVQGAHCTVNGCEVTGSCR
LSQGALVVL

ENSGT00890000139327_7_Linker_1_2 (610, 5593)

GKSHKFRFNHPAEAAVLRQR-RSINDIPPILSCRALDWLNLDKNMQKSLTC
VMQTLWR-ENREIDAVHEEYQQKLRDQEAFHRKQIQ--RQQLYVEDLKQQILRGQIKAEQ
ELENDQALINQQIQENQQWLINENNRLAALQQQQ-----REFAVQT--------ESTLYA
EAEVQSSIGQEICPSLLQQNK-KTLVQLELLRRYSLKKAERNIRRKKVK--FQLERIVKK
QKLLEAKQNLEQLEASCWLSEVCVKQPRVLNQNIAVQASRDHPLQKRRRSLGSSSLQHRQ
HSFC---NFHLPRV-------------PSCLLKGETISKLSTSPNTDQCCEGNTSEKLSS
VEHPFRKVKDVSRDDDLNDEKGTSFLVQKQLTEKQKASSF-RSKKGAERDSNDSAIMAHI
NKNDQKMEKLNDSTGQAGCQNQTSKGSSPDHFKEKDE-PQTFITGTRMTKAKVPGDL---
-SQPANSYLEQNRAQVS----------------------KMKKDVVYGNLPSAHLNQTAK
NLKREPTSALRNHEKSSVEQQEFLMVATSVGNLTKINTQTPLSYAEKKWHSAELLSAGVS
KTATDMLGNWQEDDENEISDTDSSYSVDSLSCAYAKA-FAEKLKQEDFSRNK-CFANPED
SESDDSQMSQDSLVEKENKVKMRNKSQFHKLKAPHQPARLCKSRTEHHLSSLVTSYASHR
RLGRAERSFSLDSLGDGEE--VPAEDPVEESKSDSSDEVPAEIFWKLQTPTSPTIQT--E
EDCESRNCDRDTE--GTRYNLKLSSSFYLDTKSQP------------------ASSNAC-
----------------KQF-LKE---ATVSFVQQSSCDSKVEIGSPRITVPSSHGNLEFQ
NAHLYSLSKPEGWLKKDDLKQSAAEFSF-VSGSKQIHSITHLSHSINELNS---------
------------SF-SSDTSEIPLPETTAASRVSENGSLNRITEEWTN----------AN
ENSPLESQDITSSFVSSAKPDY---YEHSTSNH-----------PEQEQLNELS--SYRS
TTECTQ-----TFGCLESTSTADCLSLVPGKEEDSLPTTHPELPKDHNLEKAPFISVLPV
HV-LEQ--RNGCVDSDLEDDFFRTIEKDDLDDDYNNLTE-SKITDLN-TGSASVNSPAAE
SSTGLTYNMASTQSSAVEQVQFGNHVQ-LF----PRREIPTCCDEGFFLSNLTNQNCS-L
GSVYEL--QVLARQGAESAVTL-GLRSG--ES-NLETMQDTDYEQIPA-EEITIDTDFSS
KKVTYKCNPLVLAYSASYDQSATP-VELSQKEKICMETSMDSLAEIVSEAPSFRDDEEYE
-PKDPELSSSNHYEFKSKPVSKNYSPECVLADGPVGCLSQ-HI-S---------------
ENSTLCTDNIR-A-----ESSESDSQVVVQKDFLPKYKNLMVNEASYLTVNVNGKDTESF
PAAVCESTNNLLPESNSSVFYQASPK---SA-SE-T-------ESCDIDS----------
--------------NDLCTTCSSKSPGE--------------------------------
-KNSMYKLTDISVEFDATIQLETKTKNKSSLES---------------------------
------RVEKEACFESDCPEDILLVEDHVN--SEFGVFEYNTNKLATVSQEESLYINKEY
KFLRKTKTDPEEAMF------------PYQNAKANTDEEETKLMNSAVN--LEKNMLEIK
SGQVESLPD--YPVPKAQSVTADR-SAENKPIDIVASEVQCEVYTNLCLTHEEAEKD---
-------ES-------QVGSTDVEHTQESKAFMCSDSCLKT-NSFCPKK-KTVCSHTT--
-----DVTQDTL--GF--------------LDACEGLLQ-----INRTTENVFD------
------------MEDVAATVLITGRQGNSLEKN--EKQVE-----S--------------
--------------SNLPEHFIPNCLPHANFDQENKVSGCEVTESEEQIIMTNTEGPTMK
HEVICA--DK-NV-LFPEE--------------------------SSALHQMNCDRDDEE
EILNQYEIPERYLTASGLEENVPSV-DDSQYCDPTEMR--------EDGGSA--------
---DPA-TDARNTVMTDTDVYECSVDDNINIDKYTIGQESKRLRFKEDSHTYMSCS----
-V-------QYPEHGTSEKLNESI------------------------IIKREICGLDSI
GSRL------GDEKVHLMNLEQMDKTDRERQMFLENTEEVELIILQNLSELFPENKDGCH
DDS-----RLDEILRESQWVSTSFSGSNEDTSKQ-----------QNP------------
PATLKSTENIHE-DSDKDSLCQSVNQLFYL----G-----------EGHTKPSNSCAGTG
AVLPYYETLVENEVCVSTPGK-TVN---------KEGADASLSDKIQSRNEAFPQNKTAL
D---------R------QEE--------EPV-V-------CGDES-ETVALKQGAEE---
NPFSVEKIDSSEDKIQDNSNSNEEPSVDLMVNNISKDCF--N-SIEERFQEEKDTIMPDS
LHLDNS-NLLSFS----EK--EVIINMTEK---ELHSG--SPS-QHDDKEKCLNTSC---
----SITSSKNDNAGFPGISGYQHEPRENQGHRTSEKCCVD--CPESAISEN-ISTLSES
LKNSLWENPHSNK--------ELL----NY-------KSSPGLMHSPVSFAEFLIDSNG-
DKCKNDAVLSEVLSRIA----MILNNT-SSMTVPE-------------------------
--------------------SG-------------MLAVQSLR----------------E
IGSKESKCLPA------------------------YFAEDAP--T-VS---------HLE
DSLQDPILTEQVSS-----GSADVQSVKEDLPQ-TCAEVNY-PSLTAFSESSSAADIDHG
VTGTCGISHTSILKHPPFA----VLQMQDTQSDKSVVFDEPVHASGSILLSLAKENRHYP
VSDT---DPTLCGTCIYDADSLSLPSL-PLWD-TGRNE-----EQLHSSTEAKQSVV---
---EKKQR--KTVNRE-------AEKQTAVSSD--------------------STSELID
PQDVTDTDFPGDVNVD-PEHTCDSF------GPAKSRSSDPRQLYHTVLGFEKSPADLQG
NCHYVPTGGANPGQTNTDARKWIV-LCKNNA------------GSSIDADADSCSTTGGD
TMKNETLKSERLKFYLMNNETNSLKFLTEDHDLPTQESKLV-QFRSKR-SWSAIQNTNSC
TRSEQRPYLQ-SHRLSAPAIAVFSDLDYTSEASSKVDPLLYSASKSLQDLNMS-VEPPSP
TEDDL-HGVERFSKQESKNFLQVKSKPRFQQRMTQTKKLANCDLKNVHYAARTQSSQSSK
DRTV---HSPS---LLHTAHSAVGAEENTHSKS---SSVAQCSEGRAEEAGYQ-------
-----PGTDKFSQ-DNKDAMHFNSSDINPYIHPWQQDELCKIGWKQYVFGSASDVSCNQM
PLNLDSRKVTRCSS--VDNGLNSQNSPFHSHLSSYATAKVLSSTLSSIEGLQGWDV-RQG
FE--SAYSSDNTKQYSNVSIETPKTN-TEN----NT-------AEFENPSV--QPGNSAM
QVDEIVLLYPSESERSSKK-SPGITCEQGTQTVA-TARYKRQRRHQRSYTDISARKQETN
RDLLQ-QHSSWTSMQNLSMHLSQLIQNTSELLGNLSQQNIIDNEQNAKISQRKTEEGAK-
-AARSDSCTQTTADIGTQTETLEEPRSKHEEKQVQVKME-NELRAAQTADC-DLEGV---
---------V---------ADVGKIPKRKEET-----LTLE----------ERAQEQTIL
--EDSFMRLPFLPRASTPTLDFQKTSLNTQQNAAFASTRVSSVTSSSLSSGKDDSSCTVV
SSPTN----STFQSPASCTLD-KRSVNEPEVPVERKL-RYKNTLLVDRASSPILTLSASP
KSQNAFSKPACSIKEPLG----YSGDALSPLH-SQRKQRSGLQ---SGIEPHVDNFSQTE
TDSESSTS-RDSKGVRNTSGGFS----DKK-----AARKFLGKDGSEDVEQQHRYTVGAH
TTICAKRLYHSSSMLEVSGHTQTLMSPQNLWKQG-QSPS---------------------
---------QSEKAKTE-------T----DSESSTS------------R-----------
------DSK-YVTGGG--------------------RGSLGGIR----HENYVGNSDSAL
IYNYSPPKSDLLFHQKSSATCLSKPYRPRSYSLRDLPIHNKFSNWCGVKGSPPPSLLSLS
---GSVTDLQS-QAETKPGSKQAME------------------IEGKSQIMSGIHLD--L
HQHPLSVELTEAKLNYGIGETDALLRVLQSGTADDLMA----IPVKQ--QLYERH-----
----------MRTIETLRKEREKRLQRYHRSRSLSPQKHFSLLQTLDASHRDLELPSRRR
EYLQQLRRDVVENTRVQEPKRR-SIQHPSEIELMLRDYQRAREETKTEIARARDKLRERA
EQEKRRIREQIFSQLQK-------EEARLKTLASTSTLCTE-SSLSLSSGPTSGYNSSNT
-AAFQTKSPHFCS-F------------------LNQVSSGNVLL-SRDARGRSAVRNSQL
YMIHRLSS-ISC-----------------RF--------THG---LTISVSSSSTKGYED
LAKHILANATTE

PF01852 // ENSGT00890000139327_7_Domain_2 (5593, 5813)

VMAACSHNLRNLYMCQAAGGWKYQCTEKEV---------LVYYKVFPS
-ATKHGFLG--AGVIERPLPSVWGLVRDPGKRHLYDRTINTARIHKKVTSHIQLVYLVTD
TSLCYLKQPRDFCCITVEAKE------ENLSVLAIQSVYDASMPHPCKDVVRGEILPSAW
ILEPDVVNGREITRVIYMAQVDLGAPAIPARLLSSIAKRQPLVIARLAHFLAS

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-------WRKEG-NLRTHKPA------KGASCSS---------SHPRGPKQAAGHGKPAR
TLC--AESKPPSPNRASKRQQR--VLAARVRDISKKPSCLPHGRCMKRQHSAGGPDMMAS
LTDASPVTDHARENDDDLSDTDSSYSVDSLSHVYAKA-LTEPLKPEDPQGKERDLPEPEN
SESNDSQISEDSLAEKEYQSPQDSPGGSCLTNSQG----HPRARARASVRGFST-SSDSG
LFAQTHRSFSLDSLVDAEE--ELGGD-QEEPFFGLADEMPTETFWHLQTSSLPIVDQ--E
AMCRLGPITYRTG-ARLDAILPTSSSFYLALQ--P------------------HCEQSES
EVEAQSSEQASTLRG-MQLSRGS---PLLSMDSWFSCDSKINPSSPPGVVGSLCPSPDVQ
EFQRCGWERSGYWLNMEELKPTGAETVL-PCSPRLLQGGARD------A------N----
-----------AVP-AVDTSRLSRWGSHRLL---QPG-----ADGTF--QARGIPDMAQQ
GHSEAS---SVSSMLAASAASF---THVGSTPEKDW------TALQQKYLFELSHPVLEA
IGEPRP-----AFSSLKEDS--GSLNQAPIKGGDTLLPVGSGVSSSLDFNNFPIHLSKIR
RLRAEKEQDSMSLELEDTSDFFTTSEIEESNSGTYS----ADVESLT-SGTTN--AQVFA
AENKIANSMV-----EAREVKQNNLEESSSQGS-RKPGLMTSSDECSLPKNPCHSNVT-I
ATKEDHWPQGCAPLRKNRAGQEGQLTHK--SH-HPLQEEKADYQESSK-EVGRRHTNLS-
--FAFPSGPELSLHSALWNPFPSS-LQPPLLETFYVTKSRDVLTETALEIPACREARVPS
PPPREAWGFGYDHQVLQNVYLKNNLPVLLQNQNSKIASSQ-QVTT---QRPIDLNTKEVS
RETGKCLGNVKEE------SH----------------------NSDYFFVAQNRHFLPST
STKVGEFESQVGILN-KHSLPALKEG---EK-AT-V------QSYCNVSSHSSGS-----
-------------WKPLLVCES-EVGGEEEQHQ-------NAVLRQTQAFGTNRQFPSGA
KSDFVYKTINLGLDKDML--GETA----LSLKSRSVHHRVSSPEKMTRDESLTHKE----
EGKNETGLLGKALHPKDSSEEGKLPWTEF-------TYER--FQSVACSQ-ERNP--NEC
KGPGQ-SQE----MLNT--KEELSGKKQNKRVN--NADEMARLIRSVMQ--LENGILEIE
SKQNKQLCVSNTLGVSKEFVIQDQ-KDQEMADHEPV------PIRHFSFKDQPSSPKQTD
DVIFR--DGEDGEM--GVDSSSGKDPQ-VRKITL----SPFQSRECIQDVKFVREHT-H-
PAVLDRPTRDTC--DY--------------LGTCTAHRE-----STNTSVNPRR------
------------TKALARALPLQSRPNKSSEKEG-KLVNA-----S--AS--PKGEPCGL
GSLEELETV-----KGFQESHVAKCVSSS--------------KQEEPKVQGRVDEMAVQ
RGGSLQEENK-MISLIQKLPSPSQ-HCMGTFFSQET-GPLLNQPGFS-RAPH-QDL-SNT
LPLNSPRLPRSYPLAS-DSIGISSVD---YVLDPTMLKMSDSP-LVTGAVC-QDQSGEPR
SCSPQG-TVA-----------------------------------GGSSIVHSAWCGSAI
SM-------AMGSRGQSSVPES--IPLGAEGRRSASTSP-QDHGENLRNTLMGLSTRVGS
APEDEAAVQGGTSRASSLNRVSSPLEVRASCLLEEGNDQGRE-VRQK---AEEVAE-DL-
--SP----------------TSGAFSAPVSLP----------------------------
-TVPHLEPSAP------TSTGL-----AMLEE----------TSQAKAQGKQLHDLVVGD
TVLPYYETLLEPECSSRAPGRPQCQQMD-----------PSVLDMTRNEGEVQGFHVASL
SAEPGHL--LTDERKVLQAT--------LLS--ADSFQPLTNTETNTR------------
-PCHPSQTSSHADP--VLGESHCTGEL-RHFLGAREQFL----SSEIIEKKKEATRTPSS
ADPLGSDSLPHSTAVEE--DRRVIP-----------------------------EKV---
----------------------------------VAALPSQALSDHPGVIPH-----GQS
QL-APRETVEDVPPGSQESSLAHKEP--RTLDTTFG-----------GDSGNFLLAAQG-
EK----------TTYFESQLVICDVQNSASLPGPKQDHVQCLEASTSLEG-R-ASPKQGP
VLPGALRRGEL-----EAPLQQCVEWKGSVGSGQPEA-CR--------------------
AGSEHPR--PP------------------------PLPDQRPSPDPGGVREE-APCRCSQ
ETLDCVVFSGSVEGSRTESPSRGQEDSRILPCRQPCGPQPI-ASHACFSPSSTLLCYRDG
DLGKGTSKAA-PH-TLHPALPSMACGMDERGESNPREAGMLLARIN----------VEFG
ASDSSTLEPSTNAAVLPLAQGCSSPAA-PEVG-TSALSHTIAATSSGSVGDPKKRIA---
---EK-AI--MELEAAPFPAGMYSEPLRKFQDSPVGGQNAQESQ-TKPEPP--VTTGRSH
TLNLSEGFVESELLV-EPQHGCLENA-VRCLPEKPQFSAESRNHSG-LVPQAKFTAKLKH
MSSP--QAD-SPWEEEEQQGYQAS-GGGEEPAQGRS-----PPRSHE-GGLDGCQIRDAS
RE-----------------EAAAAK---PKTFSSGFRESA-----ASGITQPAAQSPG-Q
PPSVREQPAA-PHRCSLPLIAVFSGPEHS-KSPPRPQFSVVSSSRSLQELNLS-VEPPSL
TDEGT-KEPNRSWNTCPRDYSSGKSAA------RTSLKMEGCDQKASSNVD----NSTAD
HRPLQPATPPY---PTSAAVSC-------MPTP---DFRTSWMSGTLE--QAQQ-EKLKR
QGGQARPEKCHSE-VDKGLLHFGSSDVNPYVLPWWPEGPAHVGWKQYVFGSAVDVSCSQT
PQGLIPSNTARCSS--MDNGLENRNSPFHSHLSTHANAQGLSSTHSSIENAQSSHEAWEV
WG--S----------------------------------------------------AAG
PVDEIMLLYPSEVGGPVEQ-SRMNTLEQGTQTQG-CR-------LHWSYTDISSAHSEAS
AVPVS-DLSTWASMHNLSLHLAQLLHSTSELLGSLSQPSVTEKEQNTK--RETPDEAPP-
-VLMMDTYTQTTVDEGVQTDLASP----------PLRLQ-APEANPQEVNV-VLEVLGT-
---DISTTS----------QEKGHVLGTLQKREA-EETAWK-TAG-----PPDPQ-----
-AESPDCRPQSPPGPS-SHLRFQKASSG--QNLPSVSPQASPDVSLPPSSQPEEPSCLAV
SSPNL----SISHSPGPCPSA-VESVGEP--RVQKEL-GPMNALLVDRASSPILTLSAST
HGLGLS-PASSSLSAPSA----HPLEDHQKLV-SS---LDLPL---DAPRPPMDNYSQTT
DESGGS---QRVGALCGEDRSPL----ERS-----SGRSFLEMSSPGSPQQ---------
-----------SPKLQVHFLEQPPQQLQPRTTTWVQS-------------------RLPP
PPLRSR----SQRLADGFVPEDMAS-LECGPLSSRGL---SQGQSKTENGSESSSSLMEP
Q-ATLDISS-SRAG--L--------PHLSP--CHVFKLTD-----------TTGL-QGST
LGPTEAYHPEGLLHP---RSQMHMAPEPQHHSLKDLPMHNKFSNWCGVQDGSPGGLGMME
-LLGTRCDLSS-EEQ-AQRPPQP---------LNDQSQDPEWSRK------EQIPLQVGA
QNLSLSVELTEAKLHRGFGETDALLRVLQSGTGEALTADEPVLSTWE--ELYARQ-----
----------KQTIETLRRERAERLQNFRRTRSLSPQKQLSLLPNRDLPSRDLDLPSRRR
EYLQQLRKDVVETTRSPGSASR-SAHPPSEIELMLREYQRVREASKVEIAQARARLQEQT
EQEKLRIHQQIISQLLR-------EEEKLHTLATSSSLCTS-SNGSLSSGVTSGYNSSPA
-FPGQLQSPDSVG-D------------------TNWPDS--RDSWTGDVRGRSAVRDSHL
NQAGSTWRTLAY-----SRRASRGS--CC-S--------PSSLSSLGTCS---SS-SYQD
LAKHIVDLSVADVMAACSNDLHNLFSHQAAAGWNYQGEEQEV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5805)

VVAQPLSHVWAAVSDPTLWPLYHKPIQTARLHRRVTKSINLVYLVCN
TALCALKQPRDFCCVCVEAK------EGQLSIMAAQSVYDTSMPRPSREMVRGEILPSAW
ILQPLTVEGKEITRVIYLAQVELGAPGFPAQCLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVVSFG
FDYCYWSVNPEDPQYASQDVVMSFIIFLSLSSNAF--LFSV--------------FQASV
G--LTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSSKKKSYALRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIH--YSVLFAFV--------SVFIDCFSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNAQAFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQFFIPYRDSVLTWLLKDSLGGNSKTIMIATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-TSLNDEKDENLKKLVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVVLRPAHGARCTVNGREVTTSCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAAG--GSLEWLDLDGDLTASRLG
LSPLLWK-ERTVLEEQCDEDHQTPRDGETSHSAQIQ--QQQSYVEDLRKQILAEEIKAER
ELELDQACISQQIKENQQCLLREETWLASLQQQ--QQ--EDHVAEK--------ELEGSV
ALDAWLQTDHEIQPSPFAQSQ-KRVVQLQLLRRHTLRAAEQNVWRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCQLQDDSTQEHPYWVPSPDA--IVPQPR-CRRRSSSCSSLSP--
QRLC---SKHMPQLQS-------------IFLSWNPSTTLPPMPDPTH----QTSEKTSS
EEHLPQAASYPPRAGHLCKNGL-HSLGHGQHYTARAAKTRKGASAPDTCLTMSPKS----
-VGIQEMQRVGKQPCHMMSQGLVSLRQSANKLKPRDE-PKILTSTTQTRRTKELADP---
-NYTQAGWQEEG-NLGTRKSA------MGAGCSS---------PCPHGPKTTAGCGKAVK
TFW--IQYKPPSPSRASKRHQR--VLAARVRDITKKSSHLPLGSPLKRQQNARDPDTMAP
LTDFSPVEDHSREKDNDLSDTDSSYSVDSLSCIFAKA-LIEPLKPEDPQGRKWDFAESEN
SENDDSQISEDSLAEKSTKSSKDRLWGNHLTNNHG----HPRIRTRAFVRDFTV-PSDSD
LFAQTHRSFSLDSLIDAEE--ELGEDQ-EEAFSGSADEIPTETFWHLENSNLPLMDQ--K
AICSLGPINYRTG-ARLDAVLPMSSSFYLDPQFQP------------------RHEQAES
QVEPSYSEQADYLQG-MQLSRES---PLMSMDSWFSCDSKINPSTPRGIVGSLCPSPDVQ
EFQPCDGERPGYWLNTEELQLSGAETVP-PDSSKLHQGSTELLCSVRDE------H----
-----------TTS-ASDKSRLSLWGIQRLV---QPG-----ADGTF--QGRGIPDMTQQ
GNSEASHNSSVSDVLAASVTTL---THVGSTHERDW------SALQQKYLLELSHPVLEA
IGEPRP-----AFPYLEENS--GSLAQASSKGGDTLFPVGPRVSSNLDLNNFPLHLSRIR
RLRAEKEQDSLNAKLEDVSDFFNTSEKVVSYDETYS----ADLESLATCGSTD--AQVFA
AENMIPNSMA-----EACEVKQNNSEE-CLQSC-RKPGLTTSSDEYFFQKNACHSYVT-T
ATKADHWPQGWAPLRKNSAVQPRQLSSN--SH-YPLEEEKIDCQESSK-EVVRRHTNVS-
--FAFSSGPELYLHSAPWNPFSPS-LQLPPLETIYVTKSRDALTETALEIPTCREVRVPS
PPPREAWGFGHNHQVLQNTYLKNNFPGLLQNQNSKIASSQ-QVTA---EIPVDLNTREVI
RESGKCPGNII-E-----ESH----------------------NSVYSSVTQNRHFFPST
STKVCEFENQVGILSKKHSF-PALEE---EE-AT-A------QSCCSASSDSTVS-----
-------------GKPLALFCESETGKEEEL----------------------------D
PNTVLRQTISVGLEKDLP--GESA----VSLKSRSVYHRVSSPVMVAQDESPTPKW----
EGKNETRVFGKVLHPKESSEEVKLPGTKP-------AYER--FQLVTCPQ-ERNP--SEC
R-------E----MLNP--KGEPSGKKQNKRVN--NTDAMARLIRSINQ--LENGILEIE
SKQSKQVYASHPPGVNKEFVFQDQ-KEQEKIDHVLK---PDSSRNALPSKDQLSSPRQTD
DTIIR--DSEAGEM--EVNN-AG-NHPQVQKTIV----NPLRSREGVQENEPVREHTH--
PDGSDRSSRDIC--AS--------------LGTHATFRE-----STNTFLHPQR------
------------MKALARALPLQPRLERSSENDG-QLVT---------AS--LKGQPWGL
GSLEELETV-----KGFQESQIAEHIR-S--------------SQEKPKAQSIVEEMPMQ
KGGSLQEENK----VTQKLPSLSQ-LCRDTFFSHETVSPLLSQAGFS-TAPSHQDL-SNT
LPLNFPRLPRSCLHAPD-ALGISSLD---CVLDLTMSKTHNSP-LVTRVEH-QDQSAETK
SHSPEE-SVR-----------------------------------GDSCEAHTVWCGSVR
SM-------AVVSHSQSGVPES--ISLGTEDKISASSSP-QDQGRDRRITLMGFSTSEDF
ASEAKVATQKEIG-VSSLNKLSRQPEKRVNFPLEEDNDQARE-PRQK---AEKKTEDL--
--RL----------------TSGVFLASVSLP----------------------------
-RMPNPELRLLE-PFDHASMCL-----AILEE----------IRQAKAQRKQLDDSVARG
TVLSYCETLLEPECSSSVAGRPQCKQID-----------QSSSDWTRNEGEAPGFHVASL
SAEQGHL--STDERK--AQG--------TSL-FADSFQPLPDTGTDRE------------
-PWHPVQAFSHAAP--TLDKKHCTGEL-RQFVGADEQFLHPSGSSEIIEKKKNATRTLPS
ADPLAPDCLY-LAPVEG--VRRVVSK-----------------------------MI---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEG--PGSQDSSPEHQEP--RTVDTTYG-----------EVSNNLLVTTQG-
EK----------TAHFESQSVICDVQKSTSPSGPKQDHLQCPEASTGFEEGR-ASPKQDT
LLPGALTRLEL-----EAPTQQCVKSKESVGSGLTEV-CR--------------------
TGSKHSR--LT------------------------PLPDQRSSPSLEGNGEG-APCRYPR
EALDCPVFSRNTEGSRTLSPSRGE-ESRTLPCQQPSSSQPV-TTQADSSHFSTLLCYRGG
DLGKELFKVAPHSIHLPCVAHSRAFEMDEKGEISYRGPDVHLTHGL----EPKDVNREFR
PTESNTYEPSTVAAVLSQAQGCSSPSA-PDVR-TSSFSYSATDRSLELIGVPETNVA---
---EKQAS--TELETASFTAGMHSEPLRQFRDSSLDGQNAQVFQ-TNPEPP--ATPQGPH
ALDLSEESAESELVAE-PQHKCLENT-TRCLLEKPQFPTESRDNNC-LDFQTKFVAKLEH
TCSP--QDN-SPWEKEEQQRDQAS-GSGEGFAQGVN-----PPPSDT-GGSAGCQILDAG
RE-----------------EVAVAKPLMSKILSEDFKDPATVLLRQTETLQPVAQRPG-H
FCTGREQLAP-NYRCSLPVIAVFSGHKHS-KSSPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNSHLRGYSSGKSVA------RTSLQAEDCNQKDSSYLD----DGTAD
HRCPKPATPPY---PMPSSLSC-------MPTP---DFVTGRMSGTLE--QAQQ-GKPEK
LGVQVRPENWCSQ-MDKGKLHFGSSDINPNALSQCPQEPALISWKPCVFGSAVHVSCSQK
PQGLTPSNVVRCSS--MDNGLEDQNSPFHSHLSTYANTQDLSSTHSSTENAQGSNEAWEI
FSRSFSAALGNPHILTSPEGRAPTSG-HDRRPQFRGPSSEVD-CLRSKPPV--TEGGPAG
PVDEIKLLYPSEAGCPGGQ-TRTNTFKQGTQTLS-SR-------RHWSSTDVSFAQPEAS
AVSTS-DLASWASMHNLSLHLSQLLHNTSELLGSLSQPGVARRVQNTK--RDILDEAPK-
-ALMMDGSTQTTVDEGSQTDLTSP----------SLYLQ-ASVAKPQEVNV-ILEGLGS-
---DISTMS----------QERGDVPGVSQKREA-EETAWK-MAQ-----PPYRQ-----
-EESTPCKPQSPPIP-SSHLRFQKASFG--QHLPSVSPSVSDAF-LPHSSQPEESPCIVV
SSPSP----SSSHSPGLFPST-SKFPGHL--RVQKKL-VPPSALLVDRASSPILTLSAST
QDLGL-PPGFLTLSAPSA----HPVKDHQKLD-SS---SDPVG-A--PRTS-VDNYSQTT
NESGGS---QRG-------RSSL----QRN-----DRRIFPELGSPHSPQQ---------
-----------SPKFQVSFLGQPPQQLQSRTTVGVQS-------------------RLLP
PPLRQR----SQMLADRFVPEEVAS-PEHGPLSSREP---IQWWSMTENGGEGSASPVKL
Q-CTLDLSS-SWRG--L--------QHLSP--CPVSELT-------------AGL-QGSA
LGLPQACQPEGLLCP---SCQMCMAPEPQHHRLRDLPVHNKFSNWCGVQKGSPGRLDLTE
-ELGANCDLSS-EKQ-EQSLPQP---------PNDHSQDPEWSQR------EQIPLQVGA
QNISLSVELTEAKLHHGFGEADALLQVLQSGTGEVLATDEPVISTWK--DLYVRQ-----
----------KEAFETLRREKAKQLRNFSQTRSLSPRKQLSLLPNKDRLIRDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHPAFDIELMLRDYQQAHEEAKLEIARAQDRLRERT
KQEKLRIHQQIIS--QLL-----REEEKLHTLANSSSLCTS-SSGSLSSGMTSGYNSSPA
-LSGQLQSPENVG-C------------------TNLPDS--RDSWIGDQRGRSAVRNN--
---------HLY-----LARASLGS--CCCS--------PCSPSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPLQTARLHQRVTNSINLVYLVCD
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGREVTRVIYLAQVELGAPAFPPQLLNSFIKQQPLVIARLASFLGS

--HSNVGSKPRLRPT-PQETKEGGRIIVEVDGRVAKIRNLKVDGRPDGFG

PF00225 // ENSGT00890000139327_7_Domain_0 (51, 421)

DSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPV
STGMGMLYLSK-----------------------------GLFIREDDCTPLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRLTEGANINKSLVTLGIVISTL-AQNSQVFSSCQSFSSSA-SDGGNSGVPSSPSGTSSD
GGRSRRQSYIPYRDSVLTWLLKDSLGGNSRTIMVATVSPAHTSYSETMSTLRYASNA-KN
IINKPRVNEDANVKLIRELRDEIGRLKAMLLSFELI------------------------
-DQLTKDWTRKWDEWKALVEHYRVDINRRRAGLVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTTKIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPARGARCSVNGREVTASCR
LTQGAVIILGKAQKFRFNHPAEAAILRQQ-RQVGEAVGGS--GSLEWLDLDGDVTASRLG
LCPLLWK-ERRALGEQIDEDHRPPRARETPHRSQVQ--QQHRYLGDVRQRILVGQIRAQQ
EPELVGASAGRQIKEDHQWLLREETWLP----------QQDHVAEK--------ELEAPV
PSDSWCQTDPETQPFPRVRSQ-KRLVHPQLLRKHALRVAEQKVKWRRAS--FQLERIVKR
QRLLEAHRRPEQLRALCWLQDDHPRRPLFQAPNPGA--LVSGPQ-CRSTWTRCSSLSL--
RRPY---G--FH-------------CLHSVFLNQDSSTTLPPLPDPTD----QLSEKIPS
ED----------------KHAL-CSSGEEQLCTAKK------ASAPGTCLTTSSGS----
-ASDQQIEGVGKQPYAVAPRSGVAVSCGVGRRCGSD-------PMLLWLWCRPAATA---
-PNGPPAWEPPY-AVGAALKK------------------------------------DEK
TNKQ-NQKQNKPQKTPNKRQQR--VLAVRVRDAAQKSSCLPHDSPLKRQHN-----TVAS
LIDASPVVDHAGEKTSDFPDAERSYSVDSLSHVCAKA-LTESLKLEEPQWKEQDLPEPEN
SESDDSQISADSLAEKGYQSPQDSPGDSYLTLGRS----HLRARAQASVKGFTT-SSGSG
LLTQTHRSFSLDSLIGEPF-----------LSAGAADEMPAETFWHLQTFSLPTGDK--E
AACRLGSVSHRTG-ARLDTVLPVSGSFYLEP--QP------------------RCEQPEL
VVEASSSEQA------VQLSRGS---PLVSMDSWFSCDSKINPSSPP---DSLCPSPNGQ
DFQPCGWERPGYWRNMEALKSSGTETAL-PHS-----PGAEPPSSVRGV------Y----
-----------PVP-ASNSSRLSLWGSSRLL---QPG-----VEGTF--QARSVSDPAQQ
GFSEASSS-SGSSLLAASATSF---TYVGSTRERDW------AALQQKYLLELSFPVLEA
TGEPRP-----VCPSLQEDS--GSLTQVSGRGGDAVLPVGPGVSGSLDVNSSPVHLSKIR
RLRAEKEQDSLSVEVEGTSDFFTTSEKEVSYSGAYS----ADVESST-SGATN--ARVSA
AESRIEHSMM-----EAPEVKQNSLEV-SSQSS-EKPGPITSSDECFVLKNPCHHIVT-I
ATKDPHWPQAE------------QLGQN--SH-PPSQDEKTDSQESSK-EAGERRSRLS-
--FTFPSGPELYLHSAPWNPLPSS-LQPPPLETFYVTKSRDALTETALEIPAFREVRIPS
PPAREAWGFSHEHQVLQNVYMKKKSPVLLP--NSKITSSQ-QVTE---ERPIDLTTKQVC
REKGERPGNVE-E-----ESH----------------------NSVYFFVTQNRHFLPST
EIKIGEFENEAGILNKH-RLPTLKPG---EK------------AYCSVSSSSCGS-----
-------------REP--LLCESEADKEEEQGQ-------NAVFRQSQAFDTKRQCPSGF
RSDFIHRTFSLGLDKDMQ--GEDA----LPLKSRLVHHRVSSPETSAQDERPAHKG----
EGKNEPKLLRKALHPRDSSRGFKLPQAKS-------AFER--LHSVTCSQ-ERSL--GER
MVPAK-PQE---TWLNP--KEEPPGKKRNKRVN--NADEMARLIRSVMQ--LENSILEME
SRQSKQLCASYTLGVSGECVSQDQ-KHQEMANDVLR---PGSSGNHQSFKDQPSALRGTA
DVTFG--DGEAGEV--EVHSRAGKDPQ-VC------------------DARSVRGHTYP-
-AVLDSPTGDTL--DH--------------SGICTVFRE-----PTGTGADPRR------
------------TKAPAGAVSSQPRPQRTSE---------------------AGRQSCGL
GSLEALEVV-----KGFQESQPAKGVYSS--------------KQDELKIQGRIEEMVVS
-RGSLHEGNR-VVSLTHKLPGPCQ-HWEDTFFSQES-SLLLSQPDSC--TAPRQDL-SNT
LPLNSARLPRSYPHAPD-AIGIPSVV---YVLDPTMLKMPTSP-LVTGVRC-QDQSGDPG
CHGPRG-DIG-----------------------------------GVPSVAHPAWAGSVI
SM-------AAGSHGQSSAPES--ITLGAEGRRSESTSP-QDHRGDFRSTSMGLSSRAGS
PSEAETAVQRGPERASSLNRASGPLERRAGCPLEEGSTRGLV-MSQK---AEEEAKDP--
--GP----------------TCGFFSAPASLR----------------------------
-QVPQPEPSARP-PS-----RL-----VVLGE----------MGQAEAQRKQPHDVVTRG
TVLCYSETLLEPEGSSGAPGRPQHPQMS-----------QSMSDRARHEGEAQGLHVAPL
SAEPGHL--SIDERTSVLQA--------TPP-STDSFCPLLNADTHPG------------
-PQCPSRPSSRADP--ALGKSHRNGKL-EHFLGAGEQSVCHSTSFEMIEQKEATR--RSS
ADPLGS-NSLPPSAAVEEA-RRVKTE-----------------------------GV---
----------------------------------EAALASQAPCDDAGGIPR-----GGG
QSTAHQEAAEDVSSGGQESSPVQQEP--GTLDNMRE-----------GGPGNFLMSAQG-
RK----------PTSLES---HQDVQNPGSLSGPNQGQVQCLEPPTGLEGR--VSPKQGI
VLPGALRGVEP-----EAPLQQRVKQEGSVSSGPAED-CR--------------------
AGGEGPR--PI------------------------PLLA----PSPGAVRED-TPHRCLQ
QSPDSVVFLGSTGGGRTLGPSGGLGGSKSHPPQHLCSPQPI-ASQGHASPSSDSLCYRGG
DLGSWASKAAPHMCHSPCMEPLGAGEW------------------------TRGESAILG
PADSSPLEPPAAAADLPLAQGCSSPSA-PDVR-TGSLSCSVADGSSRSVGNPEKKLE---
---ERKAS--TELEAAAFRTGRSSEPPRGFQDSCAGGQSAQGSQ-PKPQQP--STAG---
-------GQHSEPLVG-PQHGCLGNT-ISCLPEKTQLSTEFRDHRG-LDPKAKYVAKFKY
IPSP--QAD-SPWEEEEQQRDWAS-GGGEDPAWNRS-----PPPPEED----SC------
----------------------------------------RGSATQCGAPQPVARVPA-Q
ASSGGDQPAP-HHRCALPVLAVFSGPEH-----LRPQFSVISSSQSLQKLNLS-VEPPSL
TDEDV-QEPSRLWTPLPGGSSSGMSSV-----ARPSVKTEGCDQGASGDLD----KSTAD
PRHLPPAPPPH---PGMAHPPC-------VPTP---NFTASQLSGSLE--QAWP-GEPER
LGAQARPGELCSG-AGTEDLLFGSSDIHPRVLPWHPAGPERVGWKQCVFGGMVDVSRGCK
S---------QCC---NTDGVEGQDSAFHSCPSTCASACGLASTH-STENTQGSH-----
----------------------------------------------QELPL--TEGSAVG
PVDEVMMLCPSEAHGPVGP-PGMSTLEQGTQTLG-SGPHGN-------HPAIC-------
--CAQSDAASWASMHSLSLRLSQLLHSTSELLGSLSQPSVAEREWNTK--RETPDEAPQ-
-ALMMDSCTQTTMDEGIQTDLASP----------PLHLQ-APEANPQKVDV-VLEGLGP-
---DISITS----------QEKGHVLGTLEKREA-EETVRK-TVG-----LQDLQ-----
-EESTQCRSRSPLEPS-SHLSFWKGCFG--QNLPSLSPQASPDASPPPSSQPEEPSSLAG
SSPGT------ALPSKPCTHT-LESLGEP--RVLKKQ-GLSSALLVDRASSPILTLSAHT
QGLGLPS-GALCLSTPLA----HSLEGHQKLI-SS---PSLPL---YAPRPPMGNS-QAT
DESADT---QRVGALCGEGKSSS----EGG-----DRRPSQEVSSQGSPRP---------
-----------SAKLQVRFQQ---QQQQPGTTTG----------GPS---------RLRP
PPTRSQ----THRLALGFGPEDTAS-LECGPLSSRGP---SQRWSRTENGCVSSASPAEP
R-PALHDSF-SWEG--L--------QRHSP--CPFSEVTH-----------TPGL-QGYI
LGPTEACQPEGPLHP---SSRMCMDQ-----NLRDLPMHNKFSDWCGVQDGSPREPGVMD
-LPGTGRDCGS-GEQGQ-RPAQP---------PDDQSQ-AEWSKR------EQIPLQVGA
RSLSLSVELTEAKLHHGFGETDALLQVLQSGTGEALTAEEEAFIV-------------SF
TESIAFSLRSKQAMENLPRERAGPPQSFRRTRSLSPQKQPISTSHQDLLTRDLDLPSRRR
EYLQRLRRDVVETTRNPRSASR-SAHPPSDIELMLQEYQRAREEARVEIARARDRLRERT
EQEKLRIRQQIVSQLLQ-------EEEKLHTLATSSSRCTS-SDGSLSSGVTSGYNSSPA
-LPGQLQSPDIVA-D------------------TNSPDS--RDAWLGDVRGRSAGRNSQP
NLAGAAWRSLVYSEWGVGGGGRLRA--TC----------------LVVCFVPCPL-----
---IGVWSLCPQVMAACSDNLNNLFSRQAAAGWNHQGEEQEV---------QLYYKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNNINLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GQLSVMAAQSVYDASMPRPSKEVVRGEILPSAW
ILQPLTVEGKEITRVIYLAQVELGAPGFPPQVLSAFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDRASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQSWISQQIKENQQCLLREETWLASLQQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPRPQ-CRSKLTSCSSLSP--
QRLC---SKHVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLRKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLRKSANKLKPRHE-PKILTSTTQTRRAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASCNS---------PYPHGPRQTAGHGKAVK
TFC--TEYKPPSLSRASKRHQR--VLAARVRNITKKSSHLPLGSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRARASVRGFTA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPCPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDMSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSCPVLEA
IGVPRP-----AFPYLEEDS--GSLAQASGEGGDTSLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPGSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPHGWAPLRKNSAVQPGQLSPD--SQ-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNRQALQDAYLKTNLPVLLQNQNSKVASSQ-QVTA---EIPVDLNTGEVI
RESGKCPGNIT-E-----ESR----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPGMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
K-------G----MLNP--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPMRQHTH--
PAGSDRPARDIF--ES--------------LGKHTTCRE-----FTNTSFHPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KGFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RGRSLQEENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVHH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGTEDKISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEKETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSLEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECSSGVSGGPQCKQIE-----------LSSSDQTRNEGEAPGFHVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPNTETDRQ------------
-PWDPMQAFSHAAP--ALDKKHCAGEL-RQFAGTSEPFICHSGSSEILEKKKDATRTLSS
VDPLAPDSLLS-SPVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETVEGIPAGSQDSSPEHQEP--RALNTTYG-----------EVSGHSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANAKQDT
VLPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALHGPVFSRNPEGSRTLSASRGK-ESRTLPCRRPCSSQPV-ATRSYSCHSSTLLCCRGG
DLGKEPFKAALRTVYPPCGVPSRACEVDETGETSSRGPDVLLTHGL----EPKDVNREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--TELEATSFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVESKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHYC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQRRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSRQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPMTAIFSGPERS-KSSPTPQISVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRWWNPHLRGYSTGKSMA------RTSLQAEDSNQKASSHLD----DGTTD
HRPPKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QGQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALPWHPEEHARIGWKQYVFGSTVNVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPLHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSVSLGDPHILTSSEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPRL--AEGSAAG
PADEIMLPYPSGAGCPVGQ-TRTNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAS
AASAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDVPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASP----------TLRLQ-ASEAEPQGANV-ILDGLGS-
---HTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPPR--QHLPSVGPSVSDAF-LPPSSQPEESSCIAV
SSPSP----SPCHSPGLLPST-SEYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-SPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSVL----QRS-----NGRSFLELHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPSTTIGVQS-------------------RLLP
PPLRHR----SQTLADSFVPEEVAF-PERGPLSGREP---SQWRSRTENGGESSASPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKGSPGGVDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKELFVWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVSQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQCPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVSN---------------CSCLYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--LSGLQMTS

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 422)

RCLGLVSRETKEGGRIIVEIDGKVAKIRNLKVDSRSDGFGDTREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLNGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKECAPPPSSCRIKV
SFLEIYNERVRDLLKPSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAVLENNLPSEVASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSVT-RNGGDSGISSS-SGTSIG
GGPSRRQSYIPYRDSVLTWLLKDSLGGNSRTIMVAN-----SSYSETMSTLRYASNA-KN
I

ENSGT00890000139327_7_Linker_0_1 (422, 559)

INKPRVNEVRPS--------------------SERNF-SSL-SEKDGNLKELVLQNELK
IDQLTRDWTQKWNEWKALMEHYRVDINRRRAGVVIDSSLPHLMALEEDVLSTGVVLYHL-
------------------

PF00498 // ENSGT00890000139327_7_Domain_1 (559, 610)

-KGQWIERDHCTITSACGVVVLRPARGARCLVNGREVTASCR
LTQGAVITLGKAQTFRFSHPAEAAVLRQR-RQVGEAVGGS--GSLEWLNLDGDVTASRLG
LCSLLGK-KSKVLGEQSDEE-QLPRAGETPQRAEIQ--QQ-----DSRQRILARQIRANQ
DLEFEQAPVSWQIKEDQQWLLREETWLASLQQQ---Q-QQDHIAEK--------ELEASV
PTDSWLQTYPETQSSPLVRSQ-KRAVPLQLLRRRALRAAERNVRRKKVS--FQLERSIKK
RRLLETQKRLEQLKALYWLRDEGSQEPPHQVPSPDA--F-PGRQ-CRSKSTSSSFLSL--
RELC---LRYLP-------------QLRSVFLNRDPSSTLPPISDSTD----QTSEKTQS
EESLSQAASYPPRTGNFSNNVL-CSLGEGQLCTARAAMAGRRAWASGTRLSMSSMS----
-SSNQERGSGSQQPHWVVSQSLASLGQPANMLKPRDE-PEALTPSTQARRTKRLSGS---
-GHGPAGWQKEG-DLETHKAA------DGASCSC---------PHPHGPKQAAGHGKAAK
TFW--KESQPPSPNRASKGQKK--VLGTKVRDITKKSSHLPHGSPLKRQHSAGSPDTMAS
LTDAGPVEDPTGEKDGDLSDADSSYSVDSLSCVCAKA-LTEPRKPGNPPRREWHLPESEN
TESDNSQISEDSLTEKGNQSPQDSPGDSYLTSGHG----DPRARARASMRRFTT-SSDRG
LFAQAHRSFSLDSLIDAEE--ELGEDQQEEPFFSSADEMPTETFWRLQTSSLPVVSQ--E
AMCRLGPITHRKG-ARLDAILPMSSSFYLDSQPLP------------------RCAM---
-----------------PLSRGS---PLLSMDSWFSCDSKINPNSPLGIVGSLCPSPDVQ
EFQPSGWERPGFWPKMEELKPSGTEAVL-PYTSKLPPGGAELPCSVRAV------Y----
-----------SIP-ASDTSRLSLWGSYRLL---PSR-----VDGTF--QARGVSDPVQQ
GNSETSNNSSVPSVLPASATSF---TYVGSTCERDW------AALQQKYLLELSHPVSEA
IGEPRP-----AFTSLEEDS--GSLTQASSRGGDTVLVVGSGLSSSLKFNNFPIHISKIR
HLRAEKEQDSLGVELEGTSDFFTTSEKEVSCSGNYS----ADIESLT-SGATN--AQVSA
AENKVANSMM-----GACEIKQNHLEE-SSQSSGRKPGLMTSSDECFFLKNPCHSNVT-I
ATKEDPRPQSCAPLRKNSIGLAGPVNHN--SH-LPRQEEEADCRESSQ-EVVGRHANLS-
--FAFPSGPELYLHSAPWNSCPSS-LQPPPLETFYVTKSRDALTETALEIPACREARVLS
PPPREAWGFGQDYQALQNVYLKNNLPVLLQKQNAKIASLQ-QVTV---ERPLDLNTTEVS
GEIGKCAGSR---------------------------------NSVYFFVAQNRHFLTSA
SPKVCEYENQFGNLNKH-SL-PALEG---EK-AT-I------QSGCTVSSDSSGS-----
-------------GKP-LSVCESQARGEEGQEQ-------NAVLGQSQA-----------
----------SGFDKDML--GATA----RSLKSRSAYHRVRSPEVMAQDGSPTHRG----
EWKNETGLPGKSLQPKDSSEEFKQPWTES-------TQER--FQSVIYSQ-ERNL--TER
RGPGK-LQE----VLIP--KEPPSGKKQNKRVN--NADEMARLIKSVMQ--LENGILEIE
SKQNKQLYASHTLGVSHEFVFQD----KEMADRVAK---PGSSRNHL------SSPEYTD
DTDFR--DGDAGEM--ETSSSTGEDPQ-DQKIML----SPFKSRDWVQDIKFVREHNPP-
-AVLDRPARDPC--DY--------------LGVCTTHSE-----CTRTFVNPRR------
------------RKALARAVPFQPRPEWPSEEES-EVVHA-----S--AS--PRRQPHGL
ESLEESETM-----KGCQESHVPKHISSF--------------YPEKPKVQGRVKEMTMQ
RGESLHEQYK-MVSSTQKFLSPSQ-RCMGTFFSQET-GSLLSQPDSS--MAPHQDL-SNT
LPLSSPRLPRSYLHAPD-TIGISSVD---YVLDPTVLKMPNSL-WVTEAGC-QSQSGVPR
SHSPQG-NVQ-----------------------------------EASSRAHTACCGSAV
FV-------AVGSWDQSGAPET--IPLGTESRRSASTSP-QDLGGGPRSTSMGLSTRVDS
ASEAKVAVQKGAERASSLNWGSSPLKNRVNCPLEEGNNQCRK-VRQK---AEAAAEDL--
--SP----------------TGATFSAAVSLE----------------------------
-THPE--------PSAHTSTGL-----AVLEE----------IRETKAHGEQLHDLVTEG
TVRPYYETLLEPACSSRVPHRPQCQQMD-----------QPVSDRTGNEGEAQGFHVASP
SAEPGHL--WTDKRK-ALKT--------TPL-SGDSFQPLPNTEGNKG------------
-PRQPSQTSSHADP--ALGKSHYPGKL-RPFLRADEQCICYSGPFEIMEKKQEAIRI--S
ADPVGP-DSLPSSAIEE--ARRVTAG-----------------------------KV---
----------------------------------GAALSSQEPSDSPGVSQH-----GKS
QS-VPWEMAEGMPPGSQESNQAHQEP--RTLHTTYG-----------GESGSFTVAAQG-
GK----------TTCFESQLVIRNVQNSASLSGANQDHVQDLEASNGLEEGR-ARPKRSS
VLPGTLRRAEL-----TAPSQQCVKA-GSVGSGLAEA-CR--------------------
AGSKHLE--PA------------------------PWPDQRPSPDPGGVREE-ALCRCPQ
ETSDCVVFSGSTEGRKTLSPSGGQEGSRTLPCQQPCNPQAI-ASYACSSPSSTLLCYRDG
DLGK----AAPQTLHPACKVSCRACGMDERGESYSSDPDVFLTHGL----EPKGIHVKFG
PSDSSTLEPSATTSVLSLAQGCSSPSA-PDMK-AGSLSPSVAAGDPE-------EKA---
---KKTAR--AELEAAPFPKGVCSEPLKKFQDSSVGGQNAQESQ-TKPELP--ATTRRQH
TLNLSEGSVESELLVE-PQHECLENA-VRCLPEKPQFSTESRDHSS-LDPQAKFAAKLKH
ISRP--QVG-SPWEKKKQQREQAS-GSGEDPAQRMH-----PPRSDE-GDLDGFEMRDAG
GE-----------------EGAAAKASVPQMFSPGFKDSASDPV------VPAAQSPG-Q
PSSGREQPAL-PHRRSLPVIAIFSGPRH-SRSSPQPQFSVISSSRSLQELNLS-VEPPSP
TDEET-QGPNKLWSPHPRGHSLEKSAV------GTSLEAEGCDQKASSNVN----SSSAD
HRPLQPASPPY---PTPSAPLC-------MPTP---SFMTCWMSGTVE--PTQQ-GKPQS
LGGQARPEKWLSE-ADRGALHFSSSDINPYVLPCPPAGPAPIGWKQYVFGNTVDVSCSQS
PQGLVPSKMAGCSS--MDNGREDQNSPFHNHLSTCAN-------------SRGSHEAWEV
WD--SSLALGNHHILKGPDGAAPAKG-PDERAQFQGPPAEAG-PLRSESPW--TEGSATG
PVDEMLLLCPSEAGGPGGQ-SRMNTLEQGTQTLG-CR-------LHWSHTDIASAHLEAS
AVPVS-DLASLASMHNLSVRLSQLLHSTSELLGSLSQPGVAEKQQNTK--RESPDEAPQ-
-TLMMDGCTQTTMDEGVQTDLASP----------PLHLQ-APEASPQEVSV-VLEVLGS-
---GISTTS----------QEKGHDPGTVQKREA-EGTAWK-TTR-----PPDLQ-----
-EESTPCRPQSPAVPS-PHLRVQKAPLG--QNLPFVSPQASPNAAQPPGAQPSEPSCLAV
SSPSL----SLPHSPGPCANA-AESVGEP--RVPKKL-CPTSALLVDRASSPILALNAST
QGSELPL-GSLSLSTPLA----HPLEGHQKLV-SS---PDLPL---DSPKPPMDNYSQAI
DEAGS-------------------------------------------PQH---------
-----------SSKTLVCFLEQPHQQLQPQSPSG----------VQS---------RLPP
LLLRIR----SPRPAEGLVPEDMAP-LECGPLCSSGP---NKWQSRTENGGESSASAVEP
Q-PTANNPS-SGEG--W--------QHLSP--CPVSELTD-----------KTRL-QGST
SGPTEACQPQGLLRP---SSQTCMAPEPQHHSLRDLPVHNKFRNWCGVQDGSRGELGVTG
-LLGPR-HVST-EEQGQ-HPSQP---------PGAQSQDPARSQK------EQMPLQVGA
RNLPLSTELAEAKLHHGFGKSDALLEVLQSGTGEALTAQEPVLSTWE--ELHARQ-----
----------KQTIECLRRQRAERLQNFRRTRSLSPQKQLSFLPNRDLPTRNLDLPSRRR
EYLQQLRKDVVETTRNPGSASR-SAQPPSDIELMLREYQQAREEAKVVIARARDRLREQT
EQEKLRIRQQIISQLLR-------EEEKLHTLAASSSLCTS-SNGSL-SGVTSGYNSSPA
-LSVQLQSPGSVG-D------------------TNLPDS--GDSWVGDVRGRSAVRNSQL
NLAGSAWKNWVY-----SRRASLGS--CCCS--------SSSVSSLGSCF---SS-SYQD
LAKRIVDICLADVMAACSGDLHNLFSRQAAAGWNYQGEEQEV---------QFYNKVFS-
-STRHGFLG--TGVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNNIHLVYLVCN
PALCALKQPRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPSREMVRGEILPSAW
ILQPLTVEGKEVTRVIYLAQIELGAPGFPPHVLSSFIKQQPLVIARLASFLGS

--MANVKVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPVSKRERAEGGRVIVEVDDKVAKIRNIKVDSRLDSSWDSREKTVAFS
FDYCYWSVDPEDPKYASQEMVFQDLGTSVLSGAFRGYNICLLAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFSRKDDYSDQMASCRVKV
SFLEIYNERVRDLLKQSDRKKPYTLRVREHPETGPYVQGLTQHLVTDYKQVVKLLEEGIA
K--RITAATHIHNASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQMFSSCQSINTLT-SEGESSRVDSPPSG---G
SSGTRRPAYIPYRDSILTWLLKDSLGGNSKTIMIATISPASSSYNETMSTLRYAANA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIDRLKTMLMSFELRNSSPSWSDDRDGNLTELVLQNEIK
IEQLTKDWTSKWTDRKAIMEEYSVDINKEKAGVTIDSNLPHLMAVDDDILSTGVVLYHLR
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRSDSDQDQDIVLQGQWIERNHCWIDNHCGIVTLRPAPGARCSVNGSEVSGSCR
LSQGALVVLGKSHKFRFNHPAEAAILRLR-RSINETPPTMSYGALDWLNLDGSRISSPHY
ILSSLSK----EIDAVHEEYKQKLRDQEAFHRKQIQ--QQQLYVEDLKQQILRGQIKAEQ
ELENDQALINQQMQENQQWLINANKHLAALQQKQ-----REFAVQT--------EPTLCA
EAEVQSSTGLETCLSLLQQNK-KRLVQLELLQRYSLKKAERNIRRKKVR--FRLERIVKK
QKLLEAKQNLEQLEASCWLSEECVKQSQAPGDNIAVRSSLDHHLQKRQKLLGSSSLQHRH
L-FC---DSYLPQVPRVCTVHSLFICLTCCFLKKESISRLSTSPNIDQYF----------
---------------------------QRQLTEKQKTSSI-ENKKGGAKYSNDSAIMAYT
IKNYKKIENLDDSPGQAGSQNQTSKGSSPALFKEKGE-PKTLITGRKMTKSKVL-DL---
-SQPSSSNVAQNRAQVSNKKIRMDINGKGHRSSPESFPKQMKK-TVYGNPPSVHLNQTV-
NWRKEANSVLPSHEKSSVKEKEFLMAATSVGNLTKMNSQTPLSYVEKRWHSAEMLSAGMP
KTATDMLENWQEDDENEISDTDSSYSVDSLSCAYAKA-FPEKLKLEDFDRNK-CLANPED
SESDDSQMSQDSLIEKENKAKKQNTSQFHKLKSHHEPAKLYKSRTENHISSLVTSYASRR
RLGKAERSFSLDSLADGEE--MPAEDLVEESKSDSSDEMPAEIFWKLQTPKLSAIQI--E
EDHESKTCNRDTE--GTNYDLKLSSSFYLN------------------------------
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----------------MNNESTLVKFLPTNHGVPSQESKVV-QFRSRR---PCSMTHNTK
NCKTEHRPYLQSHRLSAPALAVFSDLDDTFKASSLADSLLYSASRSLQDLNMS-VEPPSP
TEDDL-HVIERFSKQESKNILQ--------QRMTQTKKIANCDPKNLQNYA----ARTQG
SQSLKDSTVHSPS-LLPTAHSSVGAKENIHSKS---SSVAQCIE----EAGYQP------
------GTDLFLQ-DSKDAMHFSSSDINPYIHPWQQEESCKIGWKQYVFGSASDVSCHQM
PLNLDNRKVTRCSS--VDNGLNSQNSPFHSHLSSYATAKVLSSTLSSIE-----------
---------------------------END------------TDKLKNPSA--HPGNSSV
QVDEIVLLYPSESERSSKK-SPGNTCEQGTQTVA-TARYKRQRRHQRSYTDVSARRQETN
RDLFQ-QHSSWTSMQNLSMHLSQLIQNTSELLGNLSQQNIIDNEQNIRIYQRRTEEGAKA
TTARSDSCTQTTADVGTQTEILEESQS--K----------HEEKLV--QAK-SE---NE-
-------------------LRAAKVPKRKEQTFSLEGRPQE-GTEMRNLGNTDFHDSLD-
--TS------------TSTLDFQKPSLNAQQNIAPASARVSSITSSSVSSGQDDSSCTVV
SSPTS----STFRSPSSYAQD-KRSVNELEMPAERKL-RYKNTLLVDRASSPILTLSASP
KSQNAFSKPFCPIKEPFG----SSRDTSSSLH-SQKKQKSGPR---SGMEPHVDNFSQTE
TDSECGIS-RDSKGIR---NASGSF-LDKK----A--------AKKHENY------VGN-
---SDTALIH--------NHS------PPD------------------------------
-------------SDLLF-----------NPKCSATC-------SSQANINESSEPLVGA
--ASLQFHD-LWKN--E-----------NSCSL-LSDV---------SDAQISLQNDNTN
SITETEHDTEIPLKK---STTLVKPYRPRSYSLRDLPIHNKFSNWCGVKGSPPPSSLSLS
---GSATDLRS-QAGSKPGSQQAVEIEGKSQLWGSRSREIERLQRERAQIMSGIHLD--L
HQHPLTVELTEAKLNYGIGETDALLRVLQSGTADDLMA----VPVKQ--QLYERH-----
----------MRTIETLRKEREKRLQRYHRSRSLSPQKHLSLLQTVDASHRDLDLPSRRR
EYLQQLRRDVVENTRVQEPKRR-SIQYPSEIELMLRDYQKAREETKTEIARARDKLRERA
EQEKRRIREQIFAQLQK-------EEARLKTLASTSTLCTE-SSLSLSSGPTSGYNSSNT
-ATYTASK---------------------LSSWEGQ-FSSGSALLSRDTRGRSAVRNSQL
FMIEQLQKDSTLA------LLYS-------LWR--------GL-------SSSSTQGYQD
LSKHILANATTEVMAACSHNLRNLYT

PF01852 // ENSGT00890000139327_7_Domain_2 (5607, 5805)

CQAAAGWKYQCTEKEV---------LVYYKVFPS
-ATKHGFLG--AGVIERPLAYVWGLVRDPGKRHLYDRSINTARIHKKITSHIQLVYLVTD
TSLCYLQQPRDFCCITVEAKE------KNLSVLAIQSVYDASMPHPCEDVVRGEILPSAW
ILEPDVVNGRDITRVIYMAQVDLGAPAIPAQLLSSIAKRQPLVIARLAHFLAS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKREIKEGGKIIVEVNGKVAKIRNLKVDGRPNGFGDSREKVVAFG
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRKENCAPLPASCSIKV
SFLEIYNERVRDLLKQSDQKKTYNLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAFLENNLPSEIASKINLVDLAGSERADPSYCK
DRIAEGANINKSLVTLGIVISTL-AQNSQVFNNCQSLNSAA-RDGGDSGLPSSPSGTSSG
VGPSRRQSYIPYRDSVLTWLLKDSLGGNSRTIMVATISPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIGRLKAMLLSFELRNF-HSLNEGKDENLKELILQNELK
TDQLSKDWARKWNEWQALVEHYRVDINKRQAGLVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSEQEQDIVLQGQWIERDHCTITSACGVVILRPARGARCTVNGREVTSSCR
LTQGAVITLGKAQKFRFNHPAEAAVLRQRR-QVGEALGGS--GSLEWLDLGGDVAASQMC
LCPLLWK-ERRALGEQSNKDHWPLRAGETPCGTQIPQQQQQHLVGDVRQQILVGQIRAKQ
EAEPKQLHTGLRVEDDKL--R-GETWLANLRQQP--Q--QDHAAEK--------ELEAAV
PSHSWCQTDPKTQPYPQVRSQ-SNVVHPQFLRR-----HEQNIQQRRAS--FKLERVIKK
QRLLEGHRGPEQLRALYWLQDDRLRRTPFPALCPGA--LIPGPH-RRSRLTSCSSLRL--
RRPC---SWHSA-------------QLRSVFVNRDPSTTLPPMPDPAE----QLSEE---
--YLPLAASYPPRIGHLIQHAL-CSSGEGQFGTARKALAWKGASHLGTCLTESSES----
-ASVQEVERM--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------A-LPAPLELEETQGKERDLPEPDN
SESDDSQISEDSLAEKGPRNPRDSPGHSYLTSGYG----HSQARARASGRGFTT-SSGSR
PFTLAHRSVSLDSLIDAEE--EPGDHWQGKPFFGSTDEMPAETFWRLQSPILPAGGQ--E
AVCRLGSISHRRA-PRLDAILPASSSFYLEPQPQQ------------------PCEQPEV
AVAGSPTEPATMLQD-VQPSRGS---PLVSMDSWFSCDSKINPSSPQ---HSLCPSPDIQ
EVQCCSWERPGYWLNTEELKSPGTETIL-PFSSTLPPASTELPCSIRSV------Y----
-----------TDP-VSGS--VSLCDPCSLL---HPG-----AEGTF--QASGVPDTAQQ
GVSEAS-NSSVSSLLAASASSF---TYVGSACERDW------AALQQKYLLELSHPVLEA
TGAPRP-----VSPSLKENS--DFPIQASGRGGDTILPVGPGASSSPDFNNVPTHLSKIR
RLRAEKEQDSLNVKVEGTSDFFTTSEKEASHSGTYS----ADVESLT-SGPTN--AQVSA
AENKMAYPVT-----AVQGVKKSSLEE-SSQSS-KKPGLMTSSDECFILKKPCHHIVT-I
ATKDPHCPRGGAPLRKKRAGPERQLGQN--SH-CPPQEEKTDSQESSM-EAGGRHSRPS-
--CPFPSGPELYLHSAPWNPLPSS-LQPPPLETFYVTKSRDALTETALEIPACREARVPS
PPLREAWGFGHEHQVLQSVYVENKLPVQLQNQNSKIVSPQ-QVAA---ERPVDLNTKEVC
REKGKCFGKVKET------SH----------------------NSVYFFVTQNGHFFPST
SIKVCKFENQVGILN-RHSLTTLGQG---AK-AP-V------QSHYSVSSNSSGS-----
-------------GKPLLVS-ESETGEEEGQGQ-------NTVLTQAQAFDAKGHFPSRV
RSDFTCKTIYLAPDKDKP--QGAA----LPLKSRSVRCEVSSPETLALGESPAHKE----
ERRNETGLLGKAPHSRDGSEEFKLSQTES-------TYEQ--FQSVTCCQ-ERNL--SKC
KVPGK-VLK------AN--PKEPPGKTWGERVN--NADEMARLIRSVMQ--LENGISEIE
SKQGKQLHASHPPGVSKEFIFQYQ-QDQETADSVLR---TGSFGNHPPFKDQLTSPKRTD
NVICR--ADEAGEV--EVNGSADPR---------------------GPGSRFVRGHT-Y-
LAVLDTPAKDSG--GY--------------LGVCTVCRE-----CTNASAHR-R------
------------MKASAGALPLQPRPKGASEEGK---VAS-----A--VC--LRRQPRSL
GSLEELETG-----DGVQESHPAKCIH----------------KQEEPAVRGRVEEMAAQ
RGSL--EERS-TVSATQRLPGLCH-HCVHTSFSHKS-SLLPSQPDSR-MAP-RQDL-SHT
LPLNSTRLPRSDLSAP-NTLGISSVD---CVLAPTMLEMPTSP-LAAGVEQ-QDQSGASG
RHSLQG-GGR-----------------------------------QCSSVAHSARPGSVP
SV-------AMGPHGQSSAPGS--IPLGAEGKRSASTGP-QDQGGHLRSSSMGPGSRVGS
PSRAKAAEPRGPDRAGALNGAFSLLERRVGSPLEEADNQGRE-VRQE---AE-----DL-
--SP----------------AGGAFSAPVSPP----------------------------
-VVPQSEPSAQ------PPTSL-----AVLEE----------TGQAKTQGKQLYDVVAGA
TVLPSSKTLLEPECSSRAPGRLQCPQMG-----------QSLANRTTNEAEAR-NHMAPL
SVEPGHL--SVDKRTTVLQA--------IPP-SADRFHSLPSTDTDMG------------
-PQCPSRTRSHTDP--APGGSHCTGKP-GRFLGAGEQSVCPTSSSEITEKSKEATRVSPS
ADALGSDGLPSSTASRE--EDRRVMT----------------------------GEV---
----------------------------------VAASLSQAPFEDSGQIAQ-----GRE
VL-AA---AEGMLPSHQESSPAHQEP--GTLDCTWG-----------GGSDNFQAVAQR-
GR----------TTCFESHLVISVVQNSASLSEPNQDQGQCLEASTSLEEGR-ASPKRGT
LLPGALRGLGP-----EAPSQPRVKQEGSVGSGPAEA-CR--------------------
ASMESPR--PA------------------------LLPDQS----PRGVREE-ALSRCPR
EDLGFGVSSWSPGGSKTLGLSRGQEESSSGPCWQPCSPQPV-VWGAHSSPPSTSLCYRDG
DLGRGASTAPLHPYH-PSRVPSRPWGMERR-EGRGGESGVLLAHGL----EPKGINVELG
PADSSTPEAS-ATAVLPLTGGCSSPAG-PNMK-TSPLSHSLTDGSSRSVGDPEKKAA---
---EKKVR--AELEAIPFPEGKCSETPGRVQDSSGGGQGAKGSQ-PKP-----AAAEGPH
TLNLSEWCAESELPEG-LQQGCLGND-IRCLSEEPQLPPGSRDHGG-LHPQAKLITELKY
ISRS--QVD-GLWEEEEQQRDQAA-GGREDPAGVRS-----PPHADE-GGSDSCQTRGPD
RE-----------------GRTVARSPVSKTILPSFGDSATVSLGQRRAHWPAAQGPG-Q
PPSGREQPAP-HHRGSRPIIAVFSGRRHS-----RPQFSVVSSSRSLQELNLS-VEPPSP
TEEDI-AEPNRLWTSHPRGTSSGKSVV------RTSLNAEGCDQEAFSDLD----SIAAD
LRPLPPSPPPY---SATSGFLR-------MPTP---NLTSVHPSGALE--QAQL-GKPER
QGGQARPEERHSTDVGGGALLLCPSDVNPCLLPWHPKGPARPGWRQHVFGSAVSVSRRPT
SQGPAPPNVAQ-SS--MDSRLEDQSSLFRSHLSTLASAQSLLNKCSSGGNARGLREAWEV
LG--SLPALRNPDILISSEESAPLKG-PDERAQFRGTPGEVG-SLRREPPW--AEGSAAG
PVDEIMRLYPPEVGGPIAQ-SRMDTLEQGTQTLG-CG-------SHWSYSDFS-AQS---
------DLASWASMHNLSLHLSQLLHSTSELLGSLSQPSVAEKEWNAK--RDTPHEVPQ-
-TQMMDGSTQTTVDEGIQTDLASP----------PLHLQ-APEADPQKVNV-ILEGLGS-
---DLASMS----------QGKGRVPGTLQKREA-EETVWK-TAG-----PLDLQ-----
-GEDTLCRPQSAPVPS-FHFNFQKGPFE--QNLPSLSPQASPDALLPPSSQPEEPTCLAV
GRPCL----SAFSSPGPYTQV-AESVGEL--RVQKEQ-GSASTLLVDRASSPILTLSAST
PGSGIP-LSALSLSSPSA----LSLDSRQKLM-SS---PSLPL---PAPRPPVGNSSQTT
DEADGS---RRAGAPCGEGRSSL----EEG-----DCRPFLGVSSQGSPQQ---------
-----------STKLQVCFVQQPLQQCLPRATAGVQS-------------------RLSP
PPLGNR----SQRLADSFLPEDVAS-VECGPLSRRGP---GGWQSRAEKRGEHSASPVEL
R-PALDVPS-SWGG--L--------QRHSP--CPFSELTD-----------TPGL-QGCI
LGPPVACQPGGLLPP---GSQMHTAPEPQHHGLRDIPMHNKFSDLCGPQNNSPGGPGTMD
-SLGTRCDCSS-GEQ-SQRLPQA---------PEDQSRAPEWPQK------EQIPLKVGA
QNLSLSTELTEAKLHHGFGEADALLQVLQSGTGEALAAEEEELY--------ARP-----
----------KHPAETLQRERSEELQNSRRSRSLSPKKQLTFA-------RDFDLPSRRR
EYLQQLRKDIVETTRSSGSASR-SSHPPSDIELMLQEYQRAREEAKVEIARARDQLRERT
EQEKLRIRQQIISQLLQ-------EEEKLHTLATSGSRCTS-SDGSLSSGVTSGYNSSPA
-LPSQLQSPDSVG-D------------------TNLPDS--RDSWIGEVRGRSSVRNNQL
NLASSAWKCLAY-----SRRAALGS--CCCS--------PSSLSSLGTSF---SS-SYKD
LAKHIVDLSMADVRFPAADS----------ARWGGRRERGGTGQTRASLAALYLYKRGN-
-SGNTGLRDSSKGLLCTNCAH---------------------------------------
------------------------------------------------------------
-----------------------------------------------------

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQSWISQQIKENQQCLLREETWLASLQQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPRPQ-CRSKLTSCSSLSP--
QRLC---SKHVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLCKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLRKSANKLKPRHE-PKILTSTTQTRRAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASCNS---------PYPHGPRQTAGHGKAVK
TFC--TEYKPPSLSRASKRHQR--VLAARVRNITKKSSHLPLGSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRARASVRGFTA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPCPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDMSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSCPVLEA
IGVPRP-----AFPYLEEDS--GSLAQASGEGGDTSLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPGSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SQ-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQDAYLKTNLPVLLQNQNSKVASSQ-QVTA---EIPVDLNTGEVI
RESGKCPGNIT-E-----ESR----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPGMVAQDESPAPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTYPQ-ERNP--SEC
KGPGK-SQG----MLNP--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPMRQHTH--
PAGSDRPARDIF--ES--------------LGKHTTCRE-----FTNTSFRPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KGFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RGRSLQEENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVHH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGTEDKISASTSP-QDHGKDLRITLLGFSTSKDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEKETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSLEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECSSGVSGGPQCKQIE-----------LSSSDQTRNEGEAPGFHVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPNTETDRQ------------
-PWDPMQAFSHAAP--ALDKKHCAGEL-RQFAGTSEPFICHSGSSEILEKKKDATRTLSS
VDPLAPDSLLS-SPVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RALNTTYG-----------EVSGHSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANAKQDT
VLPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALHGPVFSRNPEGSRTLSASRGK-ESRTLPCRRPCSSQPV-ATRSYSCHSSTLLCCRGG
DLGKEPFKAALRTVYPPCGVPSRACEVDETGETSSRGPDVLLTHGL----EPKDVNREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--AELEATSFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVESKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHYC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQRRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPMTAIFSGPERS-KSSPTPQISVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNSHLRGYSTGKSMA------RTSLQAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QGQQ-GKPEK
LGVQVRPENWYSQ-MDKGMLHFGSSDISPYALPWHPEEHARIGWKQYVFGSTVNVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPLHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSVSLGDPHILTSSEGVTPTLG-HDRRPQFRGPSGEAD-CLRSKPRL--AEGSAAG
PADEIMLPYPSQVGCPVGQ-TRTNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAS
AASAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDVPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASP----------TLRLQ-ASEAEPQGANV-ILDGLGS-
---HTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEESSCVAV
SSPSP----SPCHSPGLLPST-SEYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSVL----QRS-----NGRSFLELHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPSTTIGVQS-------------------RLLP
PPLRHR----SQTLADSFVPEEVAS-PERGPLSGREP---SQWRSRTENGGESSASPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWGGVQKGSPGGVDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QKLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKELFVWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVSQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQCPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLTNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MATVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRESKEGGKIIVEIDDKVAKIRSLKVGSRPDGFGDSREKIVAFS
FDYCYWSVNPEDPQYASQDVVFQDLGTEVLSGAAEGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFR-KEDCASLCSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYSQAIVENNLPSEIVSKINLVDLAGSERADPSYCK
DRIIEGANINKSLVTLGIVISTL-AQNSQAFSNCQGLSSSA-NSSGD------NSGITSN
GGPSQRQSYIPYRDSVLTWLLKDSLGGNSKTIMIATVSPAHTSYTETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELKEEIRRLKAMLLSFELRNF-SSLHD-RDENLKELVLQNELK
MDRLTKDWTQKWHEWQALIELYSVDISRRKAGVVIDSRLPHLMALDDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPVQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFSHPAEAAVLRRRK-QVGEAIGSN--GSLEWLNLDADVTASRLG
LCPFIWK-ERRVLEELSDKDRHPPRDGERSHRAQIQ--QWQCCVADLKQGIQAEQIGAKK
KLEFDQIGTRQKIGDNQQWPFREETWLANLQEQQKQQ--DNLGTKK--------ESEASV
ALDTQLQTDSEAPLPPLVRSQKNRLVQLHLPQRRVPQAGKHNILRKKAS--LQLDGYIKK
LKLLEVLERLKQLTALSWLQDDSTYQSPRWVPTSDA--AAPESP-CRSRSTSDSSLNC--
QTLG---GQHLP-------------PLHSAFLNGDLSTMLPPMPDPAH----QVSEKITL
AGHVSLASSCLPRIRCLHRSGL-CLSGQGHG----PCMAKKDTTALGTCLTVSHKS----
-VDIQEMQSMGKQLSQMVFQGLTSFCQSTDKLKSRDG-PKTFTSATQVRRDKGLPNS---
-GSAQAVSQKEG-NLGVHKAA------KGASYSY---------YYPRGLKQVAGLGRVAK
TFR--TESKLPLLGRESKRLQK--VLATRVRDIAKKYCPLPHGHPLKKQHRARDQD--AP
HTDSSPVMDCAR-GEDNLSDTDSNCSVDSLSHAYAKASLKEPLILEHPRGK-WYLPESEN
SESHNSQISEDSLVEKRDQSSKENLGGSHPTNERS----CLKTGTKASMRGFLM-PSDSG
FLARAHRSFSLDSLIDAEE--ELEEDQQEEPFLGSADEMPTEIFWHLQK---PIVDQ--E
TTYRSGPISHRAK-MELNTILPLNSSFYLNPQVHP------------------HKEWPES
ELEARYPEGTSSFQD-IQLSRGN---SRVSIDSWFSCDSKINPSSPPGIEGSSLLIPDVQ
NAQPSDEERFQYLQNIKELKPPGAETVL-PGSLKLPQGSTELPCNTGDV------L----
-----------TAF-ASGTSKLSLWRTQRLL---QPV-----TDDLL--QRGGNPDTTQP
RNSEVS---SVSSEPAASGTSF---IYVGSTHEGDW------AALQQKYLLELSQPVLEA
VGESRQ-----PFPYLEEDS--SSLAKNSDKGGGIQLSVGSAMSSSQNLNEFPIHLSKTR
HLRAEKKQDSLSAKLENASDFVSTSEKEVSCNGAYS----ADLESLA-SGSTN--VQICA
TENKTIYSLK-----EACEVRHKSLEE-CCQGS-RKLGVMTASDKYVLQKNACCRNVA-Q
ATKADHWPQGQCPLRESSSVQQGQLSHN--SS-HSQQEEKADCQKNSE-EVVGRHTDVS-
--FALPSGPELYLHSAPWNPFISS-PQPSVLETFYVTKSRDALTETALEIPACREVWVPS
PPPCEAWGFSHDHQILKKTYL-NSFPVLLQPQNSKIAFSQ-QVTA---EKPVDLNTNEVT
DKLGECAENTRKE------SH----------------------NSVHFLVAQNRHFLPFT
GTEVFELENEVGILNNKHTLPVLQER---EK-AP-T------KSCWSIFSDNSGS-----
-------------GKPFIFIYEPEISR--------------KKQAQIQAHDMSRQLPSES
RSDFICKTIDLGLEKDTP--GETA----VFMKSRSVCDRVTSST----------------
VTAQETGLLGETVHPRDSPAELKLSERVS-------TCER--VPSVICYQ-ESGP--SEC
QGPKR-SQE----MLNS--KKEHLRKKQFKRFN--NADEMARLIKSVMQ--LENGILEIG
SKQNKQLYASHTPGVSEEVVSQER-ADHDLRPGS--------SGNYLSCKDQSSSPRRAD
DVVFR--DSEAREM--ETNRTTGNKNQ-VQKMPP----SPVRSRECVQESQIVVEHT-H-
RARVGRSPRDMG--DS--------------SGRGTACKK-----STRTTLHQKR------
------------MKVLCRAPPLYPWLE-NSGKEV-RLVQA-----S--AK--FKEQPWGL
ENLEDLETV-----EVFQESQVTECINSS--------------KPNSPRAQGEIEEMALQ
MGGRPTDKSN-MVSLTQKHPGPNQ-HSTCIYFSQETISPLLSQTDFS-MAPSNRNL-SNT
LSLPSPKLPGSCFQAP-DTIGNSLVD---HVLDPTILKIPDSP-SEHGVGY-DSQSRENR
RPHVQG-EIR-----------------------------------RGSSAAYSAWDGDVR
PL-------DLELHGQSDTAES--VPLGTQERITVNTSP-KDQGGDLGVTSIDLSAQEGF
GSETEAAVQKEIPA-TPSKTVSTQLDKRVSFSLEEEDDQSRG-ARQK---SHE-TE-DQ-
--GP----------------ASRAHSASISMP----------------------------
-RVPDLDPRVI-ETSVHASICL-----AILEE----------IRQAKFWRKWPSDFRAEN
AVLTYRETSVEPECSSGDPNRTHTEQIN-----------QLTQGRTRHKGETPEGHVASL
SAAPQHL--LADKRKDQA-T--------HLC--IDGSGSLPSSDMNSE------------
-PQLPPQSASFAAP--APGKRYCPRDL-WSFQESREGFVDHSSSSTIIEKKKEVFRTPSS
AGPLILDRLLPPGAVEA--DRMVGS-----------------------------EKA---
----------------------------------VSALSSQAPHDDPGPILC-----GQR
SL-AAWHTGEGMSPGSCTSSPEHQEP--EAIDTTYG-----------ELSGNFLVTAQG-
RK----------TALFESQSVIRSVERSLSFSEIKQDHNQCPEASTGLEDVR-ANPGQQV
VLPGAQRNAEL-----EFPTQQSVKWEENVGV-------R--------------------
IGSKNLR--PT------------------------PLLDQRPGPDPR--RDE-ALCRGPE
ETGDCPILPGATEGSRALSTVRDAEEIKTVPCQQLCCSQTT-AAHTCSSHSSTLLCHRHG
DLGTNSQAVP-CPVYPPFIVPSRACEMDEIGETSSKEADMFLAHGS----EPKG--MDFG
PAD-GVLGPSTAAAVGLPPQGCSSLCT-SSVR-THSLTPSATNGSLRTVEDLEEKVA---
--KRK-VS--TEFESAPCLAGMHSEPLRNLRDHFVGGQNAQVFQ-TKREPP--AETQGPH
IQRLSEEFIE-------SEHGCLEN--SRCLSEKPQPSTESRDP------PAKFV--AKH
ICSS--QGD-SPWEDKEQQRDWPS-GGGKDRPQGRN-----LPLPDQ-GSLNSHHIRGAE
RE-----------------EVAVTTFPASQAYLAGFEDPAPMLLGHSEVQQPAAQRPG-Q
LYSNEEQSTP-HHRCSFPMTAVFSGPKHSSRSNPRSQFSVVSSSQSLQELNMR-VEPPSP
DKD-A-QGLHGLWNPHLPGYSSAKMMT------GTPLKTEDSNPMDPFKLN----SSPAD
HMPLKSATPPY---PVSSTVSG-------MPTP---DFMNSWVSGTMV--PQGEPEKLDV
-----QVRSENGQ-IDKGMLCLGSSDINPCFPPWCPEGPMHIGWKQYVFGRAVNVPCSQK
ALGPVPSNVAWCSS--MDNSLGDQNPPFLSTY---TQTQDLSSTHGSTENVQDSNETWNI
LG--TSFALGC-----------NPSG-PDKIPQFKDPTSKAG-CLKSGLPL--AEGSSVG
TVDEIVLLYPSETDSHLAR-ARTNTYEQGTQTSG-CQ-------LHQSCADVFSAQPDTS
VVSPC-DLASLASMHNLSLHLSQLLNSTSELLGSLSHPGVAKE-QTSK--RDPSAGALH-
-TLRLDSGTQTCVEKDSQTDLTLP----------PLHLQ-APEAKTQEVIV-IPEVLSS-
---DTTPES----------QVTGA-----LERDA-EEVTWK-ATV-----PSDLH-----
-EESAHCRLRSPPVPS-LHLRFQKALRE--QNLSSVSPPASLDAS-----QARDASYVIV
NNTSL----STSHTPGPFPTA-SESAKEP--QVQEKL-DPTSA-LVDRASSPILTFSAST
QELGPP-LGFLTFSASST----CPLECHQKLD-F-------------SPRPAADSCSQIT
HEPGGF---QPVEALGGKG----------------SSKSFLESSPPCSPPQ---------
-----------SLSVQVSFLEQPLQQPQPSTTTGGQS-------------------SPPP
PPPRHC----GQKLTDSFVSVEAVL-PEHGPRSSQGP---SQWQSRPKNGGESAAPLVEP
Q-FPEDLSS-SWKG--P--------LHHNS--CPAAELTE-----------PAGT-RGST
AGSPQACHLQGVLCP---GSQMCMAPEPHHCSLRQLPVHNKFSNWFGVQHGSRG-LGVNE
-L-EASSDLSS-GEQ-GQMFP-Q---------LDNQNPDPEWSPR------EQVSLQVGA
QSTPLSVELTEAKLHHGFGQADALLQVLQRGTGAALAPDEAVMSTRE--EFHARQ-----
----------RQTAETLKREQAERLQNFRRTRSLSPHKGLSLQPNRAFPSWDLDLPSKRR
EYLQQLRKDVVETTRSPESALS-SAHPPTDMERMLRNYRWAREKAKVEIAQARERLRERT
AQEKLRIHQQIVSQLLK-------EEEKLHNLAHSSSPCTS-SSGSLSSGITSGYNSSSA
-LSGQLQSPESVR-D------------------SHLPGS--RETWMVNGRSRSAFRNSHM
YLAGSTLKSSAY-----GHRGSVGT--CCWS--------PSSLSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSCEATAGWNYQGKEQEV---------QLYYKEFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5785)

GMVVQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTKSISLVYLVCN
ASLCALKQPRDFCCVCVEAKEVPAS-QGHLSVMAAQSVYDTSMPRPSRQMVRGEILPSAW
ILQPVTMGGKEITRVIYLAQVELGAPGFPPHHLSSFVRQQPLIVARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGKIIVEIDDKVAKIRNIKVDSRPDSFGDSREKVVAFS
FDYCYWSVNPEDPQYASQDVVFQGLGTEVLSGAATGYNVCLFAYGQTGSGKTYTMLGTPV
S--LSPVVSCS-----------------------------GLFIREEDCASLPSSCRIKV
SFLEIYNEQVRDLLKQSDKKKSYTLRVREHPEMGPYVQGLSQHVVTSYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYSQVIMENSLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQPFSNRQSLSSPA-RSGGGDSGTPCSLGTSSA
GGPSQRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYRETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IVNKPCVNEDANVKLIRELREEIRRLKAMLLSFGLM------------------------
-DKLTKDGTQKWHDWQALMEHYSLDVGRSRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVTLRPAQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5612)

GKAQKFRFSHPAEAAVLRRR-RPVGEAIGSS--GSLEWLDLDADVTASHLG
LCPLLWK-ERRVLEKQSDKAHQPPRDGETSHRAQIQ--QQQCCVDDLRQQIQAGQIRVEK
ELELDQACSRQKIGDNQQWLFREETWLARLQEQQQQE--DNLGAEK--------ESEASG
TPDAWLRTDPEALPPSLVRSH-K-------------RVVEQNIPRQKAS--LQVDRFIEN
QRLLEAQARVEQLRALCWLQDDSTQQSPCWIPCFDA--TAPEPP-RGSRWTPCSSLSC--
QRLC---NR-FP-------------CLHSAFLNWDLCTVLPPMPDPTH----QVSEKIPL
ADPVSPAAACLPRTRHLHK------------------------SAPGTCLSTSHKS----
-VNIQEMERVEKQLSQMVSHGIASLCQLPDKLKPRDG-PKTLTSTTQTRRAKGLADC---
-GNTQAVSQKEG-NIGANKAA------RGTSYSY---------SYPHGPKQAAGLGRVAK
TFQ--TESKLPFPGRESKRHQR--VLAARVRDIAKKYCHLPHGHPWKRHHSVCDPDTTAS
HTDSSPRMYCARGD-DDLSDTDSSYSVESLSCVYAKI-SLTEPLTLEDPPGKWYLPESEN
SESYNSQISEDSLVERGDQSL---KGGSHATNELS----HPRSRIKASARGFPT-PPDSG
LLARAHRSFSLDSLVDED--------HQEEPFLGSADEMPTEIFWRLQNSILPVVDQ--E
AMCRPGPTSHRTG-VGLNAILPVSSLFYLNPCFQA------------------D-KWPES
EVEASHPERASSLQG-TQLLRES---SLVSMDSWFSCDSKINPSSPPGIEGSLCLRPDVQ
EVQPFDEERLPYLQNSKEVKP----VVL-PRGLKLPQASTELPCNTDVR-----------
-----------TTF-ASNISKLSLWGTQRVL---QPG-----ADDFF--QGRSSPDTTQR
GNSVVSNSIAL-SEPTASTMSF---THVGSTHEGDW------AALQQKYLLEVSHPVLET
VGQPRP-----AFP-LEEDS--SSPVKNFGKGRDTQLPVGPGVSSSLNFNNFPIHLSKTR
CLRAEKEQESLSAKLESASDFFSTSEKEVSCNGAYS----ADLESLA-SGSTN--AQDCA
TENKLTYSLK-----EASKVRQKSMEE-CCQGS-RKPGVTTSSDKC----NACCRSVT-Q
ATKADHWPQGWSPLRKNSAVHQGQISHN---C-YPQQEEKEDCRESSK-EVVGRNTDVS-
--FALPSGPQPYFHSAPWNPFSSSLLQPPVLETVCVTKSRDALTETALEIPACREVRVPS
PPPREPWGFSHDHHILKKTNLKNNLPVLLQNQNSKFAFSQ-QSTA---ERPVDQNTVEVT
GELGECTENIK-E-----ERH----------------------NSVHFLVAQNRCFLPFT
GTEVCELEKEVRVLNKKHSFPALNER---EK-AP-T------QSCWSVSLGNSGP-----
-------------EKPFLFICEAEAGRKEDQA-------------QIQAHDLSSQFPSGR
TSDFICKTTDLGLEKDMP--GETA----AFLKSRSECHRVSSPTIVAQDESSTHKW----
EGRNETGFLGETVHPKDSPTELKVSETEC-------TCER--VQSVTCYQ-ERSP--REC
QSPGG-SQE----MLNS--KEELLGKKQYKGVN--NTDEMAKLIRSVMQ--LEDGILEIE
SKQNKQLHASHTPRVSEEVMSQDQ-KDPERADHVPR---PRSSGNRLSCKDQPSSPRRAD
DVDFR--DSEAGGM--KANRTTGNENQLIQNVSP----SPFRSGECVQETQSVVDHAPP-
-AVLDRTLRDTC--DS--------------LGKGADCKE-----STNTALHQRR------
------------MEALSRAPSLHPRVESCGKDDR--LVQA-----S--AN--FQEQPWSL
GSLEELETM-----EGFHEGQVVEFISSS--------------KPEGARAQGGVEGVTLE
MGGSSQDKSN-VVSLTQRHPDASQ-HCLCTYFSQETVSPLLSQTDFL-KVPSNQDL-SNT
WSLPSPKLPGSCLHTPD-IIGISSVD---QVLDPTILKIPDSP-SEHGVQY-DSPRREDR
SPHLQG-HTS-----------------------------------GGSSMAYTAWCGNAR
PT-------ILGLHGQSDAAKS--APLGTEERVTASISP-QDQGGDLRITFMGLSAQESF
GNEIEAAVQKKIQ-TTSLNMTSRQLKKRVSFSLEEDGDQGRG-ARQK---TQEEAKDQ--
--SP----------------TSSTCLVSVSLP----------------------------
-RAPNPEPRLLE-ISVHVPSCL-----AILEE----------IRLAKVWKKWPNDFGTGV
AVLPYYETSVEPECSSGAADRTHCEQMD-----------QLMPGRTRGEDEAPEFDVASL
SAAPGHL--LADGKK--GQA--------TPL-CTNSSGPLLGPEMNRG------------
-PQPFPQSSSQAAP--APGTRSCTGDL-SDVQGARKD------SFQITEKKEEVPRTPSF
TGPLILDRLLPSKAVEV--DRILRSK-----------------------------KA---
----------------------------------VYAVSSQAP-KHSGPILH-----GQS
RL-ATWHTVEGKSPGSCTSNPEHQEA--ETLDTTYG-----------GGSGNFLVTAWG-
GK----------TAHFENQSVIFGVENSLSFSGPEQDHVQCSETFTGLEEVR-ASLKQQA
VLPGALRNADL-----EAPSQQYVNWKENVWV---------------------------R
TGIRNLR--QP------------------------LLLDQRPSPDPGG--DE-ALCRGLE
GTRDCLVLSGTTEGSRALSAVREAEESR--IRRHLCHPQTT-ATYACSSHFSTLLCHRDG
DLGTN-SKATPCPVYPPFIVLSRGCEMGET-ETSSKEADVLLAHGC----ETRGV--DLG
PVGSGVLEPSTAAAVRPPTRGCSSLCT-SYVR-THSLTQSATDGSFKIVKGTE-EVA---
---ERKAS--PELEAVPCPADPYSEPLRNLRDHSVGGHSAQVSQ-TKPEPS--AETQGPH
TLRLSEGSVESE-------HGCLEN--IRHLSEKPRPSIESRD------PPAKFLA--KH
ICSP--RGG-SPWEEQEQQRDWAS-GGGEDPPQGRN-----PPLAEQ-GGLNGCHIRD--
-------------------EVAVTKSPVSQTFLTGFEGPAS--------------RPG-Q
LDSSAEQLTP-HHRCSLPIITVFSGPKH-SKSSPRPQFSVVSSFRSLQELNTR-VESPSP
PDEDA-QGLHRLWNTHLRGYSTGKMVT------GTPLKTEDCNPTASSNQN----DGPTD
HMTLKHATPPY---PVSSTVSC-------MPTS---DFMNSWVSGTLA----PQ-GKPEK
LDVQVRPENG--Q-EDKGMLYLGSDDINPCIVPWCPEGPVHIGWKHCVFDRAVDDSYSQK
AHGPLPSNAAWRSS--MDNSLGEQNSPVYSCLSTYAQTQDLSSTHGSTENVQGSNETWNI
------------------------------------------------------EGNSVG
AVDEIVLLCPSESGCPLAQ-GKTDTYEQGTQTLG-CQ-------LHQSGADVSSAQPDTS
VAPPC-GLASWASMHSLSLHPSQLLHSTSELLGSLSQPGVT-KEQNTK--RDPTGGALQ-
-ALRMDSATQTSVEKGSQTDLSLP----------PLYFQ-GPEAKPQEVSV-ILEVLSS-
---DTTPVS----------QEKGGVIGDLERE-E-EEMAWK-AIV-----PSDLH-----
-KESAHCRQRSSPVSS-SHLRFQKALRE--QNLPSGSPPGSLDASPLPRSHPGDSSCVVV
NSPSL----GMCHTPAPLPRA-SEPNLEP--QVQRKP-SPTSASLVDRASSPILTLSANI
QEVGLPP-GFLTLSAPSA----HPLKGHPKLD-FS-------------PKPPADNCSQTT
HEPIEA---------------LD----QGV-----SRKSFLELSLPCSPPQ---------
-----------SPSVQVSCLGQPLQQPQPRTTTG----------AQS---------SPPL
PPRRHW----SWRQADSCVSEGVTS-PEHGPLNSRVP---GQWQSRLENEDESSGPPVEP
Q-LTADLSS-SWKG--P--------QHLSP--FLGAELTD-----------PAGT-RGST
ACSPQACQPQG-VCS---SSQMCMSPEAQHCNLRDPPVHNKRSNWCGVQCGSPGGLVVSE
-DLEASSDLSS-GEQRQ-GLPQP----------GDQSLYPEWAPR------EQVSLQVGA
QNTLLSVELTEAKLHHGFGEADALLQVLQQGTGAAFVPDEAAVSSWE--QHHARQ-----
----------RQAIKILKREQAERLQNFPRTRSLSLQKKLSLLSNRTFPSWHLDLPSKRR
EYLQQLRKDVVEITRSPESALN-SAKPHSDIERMLRDYQQAREEAKVEIERAQERLQEQT
TQEKLRICQKIISQLLR-------EEEKLLTLASSSSPCTS-SSGSLSSGVTSGYNSSRA
-LSGQLQPPES-R-D------------------LNLLDS--RDTRIGDGRSCSAVRSSHP
YLARSAPKSSAY-----SCRGSLGS--CCCS--------LSSLSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSRQATS

PF01852 // ENSGT00890000139327_7_Domain_2 (5612, 5806)

GWKYQGEEQEV---------QLYYKEFS-
-STRHGFLG--AGVVAQPLSQVWAAVSDPTLWPLYHKPVQTARLHQRVTNSISLVYLVCN
ASLCVLKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKIVRGEILPSAW
ILQPVTVEGKEMTRVVYLAQVELGAPGFPPHLLSSLIKQQPLIVAKLASFLGS

-----------------------GKIIVEIDDKVAKIRNIKVDSRPD

PF00225 // ENSGT00890000139327_7_Domain_0 (48, 421)

SFGDSREKVVAFS
FDYCYWSVNPEDPQYASQDVVFQGLGTEVLSGAATGYNVCLFAYGQTGSGKTYTMLGTPV
S--LSPVVSCS-----------------------------GLFIREEDCASLPSSCRIKV
SFLEIYNEQVRDLLKQSDKKKSYTLRVREHPEMGPYVQGLSQHVVTSYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYSQVIMENSLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQPFSNRQSLSSPA-RSGGGDSGTPCSLGTSSA
GGPSQRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYRETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IVNKPCVNEDANVKLIRELREEIRRLKAMLLSFGLM------------------------
-DKLTKDGTQKWHDWQALMEHYSLDVGRSRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVTLRPAQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5612)

GKAQKFRFSHPAEAAVLRRR-RPVGEAIGSS--GSLEWLDLDADVTASHLG
LCPLLWK-ERRVLEKQSDKAHQPPRDGETSHRAQIQ--QQQCCVDDLRQQIQAGQIRVEK
ELELDQACSRQKIGDNQQWLFREETWLARLQEQQQQE--DNLGAEK--------ESEASG
TPDAWLRTDPEALPPSLVRSH-K-------------RVVEQNIPRQKAS--LQVDRFIEN
QRLLEAQARVEQLRALCWLQDDSTQQSPCWIPCFDA--TAPEPP-RGSRWTPCSSLSC--
QRLC---NR-FP-------------CLHSAFLNWDLCTVLPPMPDPTH----QVSEKIPL
ADPVSPAAACLPRTRHLHK------------------------SAPGTCLSTSHKS----
-VNIQEMERVEKQLSQMVSHGIASLCQLPDKLKPRDG-PKTLTSTTQTRRAKGLADC---
-GNTQAVSQKEG-NIGANKAA------RGTSYSY---------SYPHGPKQAAGLGRVAK
TFQ--TESKLPFPGRESKRHQR--VLAARVRDIAKKYCHLPHGHPWKRHHSVCDPDTTAS
HTDSSPRMYCARGD-DDLSDTDSSYSVESLSCVYAKI-SLTEPLTLEDPPGKWYLPESEN
SESYNSQISEDSLVERGDQSL---KGGSHATNELS----HPRSRIKASARGFPT-PPDSG
LLARAHRSFSLDSLVDED--------HQEEPFLGSADEMPTEIFWRLQNSILPVVDQ--E
AMCRPGPTSHRTG-VGLNAILPVSSLFYLNPCFQA------------------D-KWPES
EVEASHPERASSLQG-TQLLRES---SLVSMDSWFSCDSKINPSSPPGIEGSLCLRPDVQ
EVQPFDEERLPYLQNSKEVKP----VVL-PRGLKLPQASTELPCNTDVR-----------
-----------TTF-ASNISKLSLWGTQRVL---QPG-----ADDFF--QGRSSPDTTQR
GNSVVSNSIAL-SEPTASTMSF---THVGSTHEGDW------AALQQKYLLEVSHPVLET
VGQPRP-----AFP-LEEDS--SSPVKNFGKGRDTQLPVGPGVSSSLNFNNFPIHLSKTR
CLRAEKEQESLSAKLESASDFFSTSEKEVSCNGAYS----ADLESLA-SGSTN--AQDCA
TENKLTYSLK-----EASKVRQKSMEE-CCQGS-RKPGVTTSSDKC----NACCRSVT-Q
ATKADHWPQGWSPLRKNSAVHQGQISHN---C-YPQQEEKEDCRESSK-EVVGRNTDVS-
--FALPSGPQPYFHSAPWNPFSSSLLQPPVLETVCVTKSRDALTETALEIPACREVRVPS
PPPREPWGFSHDHHILKKTNLKNNLPVLLQNQNSKFAFSQ-QSTA---ERPVDQNTVEVT
GELGECTENIK-E-----ERH----------------------NSVHFLVAQNRCFLPFT
GTEVCELEKEVRVLNKKHSFPALNER---EK-AP-T------QSCWSVSLGNSGP-----
-------------EKPFLFICEAEAGRKEDQA-------------QIQAHDLSSQFPSGR
TSDFICKTTDLGLEKDMP--GETA----AFLKSRSECHRVSSPTIVAQDESSTHKW----
EGRNETGFLGETVHPKDSPTELKVSETEC-------TCER--VQSVTCYQ-ERSP--REC
QSPGG-SQE----MLNS--KEELLGKKQYKGVN--NTDEMAKLIRSVMQ--LEDGILEIE
SKQNKQLHASHTPRVSEEVMSQDQ-KDPERADHVPR---PRSSGNRLSCKDQPSSPRRAD
DVDFR--DSEAGGM--KANRTTGNENQLIQNVSP----SPFRSGECVQETQSVVDHAPP-
-AVLDRTLRDTC--DS--------------LGKGADCKE-----STNTALHQRR------
------------MEALSRAPSLHPRVESCGKDDR--LVQA-----S--AN--FQEQPWSL
GSLEELETM-----EGFHEGQVVEFISSS--------------KPEGARAQGGVEGVTLE
MGGSSQDKSN-VVSLTQRHPDASQ-HCLCTYFSQETVSPLLSQTDFL-KVPSNQDL-SNT
WSLPSPKLPGSCLHTPD-IIGISSVD---QVLDPTILKIPDSP-SEHGVQY-DSPRREDR
SPHLQG-HTS-----------------------------------GGSSMAYTAWCGNAR
PT-------ILGLHGQSDAAKS--APLGTEERVTASISP-QDQGGDLRITFMGLSAQESF
GNEIEAAVQKKIQ-TTSLNMTSRQLKKRVSFSLEEDGDQGRG-ARQK---TQEEAKDQ--
--SP----------------TSSTCLVSVSLP----------------------------
-RAPNPEPRLLE-ISVHVPSCL-----AILEE----------IRLAKVWKKWPNDFGTGV
AVLPYYETSVEPECSSGAADRTHCEQMD-----------QLMPGRTRGEDEAPEFDVASL
SAAPGHL--LADGKK--GQA--------TPL-CTNSSGPLLGPEMNRG------------
-PQPFPQSSSQAAP--APGTRSCTGDL-SDVQGARKD------SFQITEKKEEVPRTPSF
TGPLILDRLLPSKAVEV--DRILRSK-----------------------------KA---
----------------------------------VYAVSSQAP-KHSGPILH-----GQS
RL-ATWHTVEGKSPGSCTSNPEHQEA--ETLDTTYG-----------GGSGNFLVTAWG-
GK----------TAHFENQSVIFGVENSLSFSGPEQDHVQCSETFTGLEEVR-ASLKQQA
VLPGALRNADL-----EAPSQQYVNWKENVWV---------------------------R
TGIRNLR--QP------------------------LLLDQRPSPDPGG--DE-ALCRGLE
GTRDCLVLSGTTEGSRALSAVREAEESR--IRRHLCHPQTT-ATYACSSHFSTLLCHRDG
DLGTN-SKATPCPVYPPFIVLSRGCEMGET-ETSSKEADVLLAHGC----ETRGV--DLG
PVGSGVLEPSTAAAVRPPTRGCSSLCT-SYVR-THSLTQSATDGSFKIVKGTE-EVA---
---ERKAS--PELEAVPCPADPYSEPLRNLRDHSVGGHSAQVSQ-TKPEPS--AETQGPH
TLRLSEGSVESE-------HGCLEN--IRHLSEKPRPSIESRD------PPAKFLA--KH
ICSP--RGG-SPWEEQEQQRDWAS-GGGEDPPQGRN-----PPLAEQ-GGLNGCHIRD--
-------------------EVAVTKSPVSQTFLTGFEGPAS--------------RPG-Q
LDSSAEQLTP-HHRCSLPIITVFSGPKH-SKSSPRPQFSVVSSFRSLQELNTR-VESPSP
PDEDA-QGLHRLWNTHLRGYSTGKMVT------GTPLKTEDCNPTASSNQN----DGPTD
HMTLKHATPPY---PVSSTVSC-------MPTS---DFMNSWVSGTLA----PQ-GKPEK
LDVQVRPENG--Q-EDKGMLYLGSDDINPCIVPWCPEGPVHIGWKHCVFDRAVDDSYSQK
AHGPLPSNAAWRSS--MDNSLGEQNSPVYSCLSTYAQTQDLSSTHGSTENVQGSNETWNI
------------------------------------------------------EGNSVG
AVDEIVLLCPSESGCPLAQ-GKTDTYEQGTQTLG-CQ-------LHQSGADVSSAQPDTS
VAPPC-GLASWASMHSLSLHPSQLLHSTSELLGSLSQPGVT-KEQNTK--RDPTGGALQ-
-ALRMDSATQTSVEKGSQTDLSLP----------PLYFQ-GPEAKPQEVSV-ILEVLSS-
---DTTPVS----------QEKGGVIGDLERE-E-EEMAWK-AIV-----PSDLH-----
-KESAHCRQRSSPVSS-SHLRFQKALRE--QNLPSGSPPGSLDASPLPRSHPGDSSCVVV
NSPSL----GMCHTPAPLPRA-SEPNLEP--QVQRKP-SPTSASLVDRASSPILTLSANI
QEVGLPP-GFLTLSAPSA----HPLKGHPKLD-FS-------------PKPPADNCSQTT
HEPIEA---------------LD----QGV-----SRKSFLELSLPCSPPQ---------
-----------SPSVQVSCLGQPLQQPQPRTTTG----------AQS---------SPPL
PPRRHW----SWRQADSCVSEGVTS-PEHGPLNSRVP---GQWQSRLENEDESSGPPVEP
Q-LTVDLSS-SWKG--P--------QHLSP--FLGAELTD-----------PAGT-RGST
ACSPQACQPQG-VCS---SSQMCMSPEAQHCNLRDPPVHNKRSNWCGVQCGSPGGLVVSE
-DLEASSDLSS-GEQRQ-GLPQP----------GDQSLYPEWAPR------EQVSLQVGA
QNTLLSVELTEAKLHHGFGEADALLQVLQQGTGAAFVPDEAAVSSWE--QHHARQ-----
----------RQAIKILKREQAERLQNFPRTRSLSLQKKLSLLSNRTFPSWHLDLPSKRR
EYLQQLRKDVVEITRSPESALN-SAKPHSDIERMLRDYQQAREEAKVEIERAQERLQEQT
TQEKLRICQKIISQLLR-------EEEKLLTLASSSSPCTS-SSGSLSSGVTSGYNSSRA
-LSGQLQPPES-R-D------------------LNLLDS--RDTRIGDGRSCSAVRSSHP
YLARSAPKSSAY-----SCRGSLGS--CCCS--------LSSLSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSRQATS

PF01852 // ENSGT00890000139327_7_Domain_2 (5612, 5806)

GWKYQGEEQEV---------QLYYKEFS-
-STRHGFLG--AGVVAQPLSQVWAAVSDPTLWPLYHKPVQTARLHQRVTNSISLVYLVCN
ASLCVLKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKIVRGEILPSAW
ILQPVTVEGKEMTRVVYLAQVELGAPGFPPHLLSSLIKQQPLIVAKLASFLGS

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--------------------------------------GVSCLWLEG--VSQLQQ-----
----------KKTIETLRRERAEGLPNFRRTRSLSPQKHLSFLLSKDLPTWEHDLPSRRQ
GYLQQLRKDVVETTRIPEPAPR-SAHPPSDIELMLRDYHQAREEAKVEIAKAQDRLRQRT
EQEKLKIRQQIISQLLK-------EEEKLQGLANSSSLCTS-SNGSLSSGITSGYNSSTA
-FSGHLPSLEVKE-D------------------SRVPDF--RDTWIGDWRGRSTVRNSQL
YLTGSSWKSLAH-----RCRAPLGS--GSCS--------PSSLSSLGTCF---SS-LYQD
LAKHIVNTSMADVMAACSDNLYNLFSRQATAGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVLQPLSRVWAAVSDPTLWPLYHKPIQTARLHQRVSNSISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPNRKMVRGEILPSAW
VLQPVIMEGKEITRVVFLAQVELGAPGLPPHLLNSFIKQQPLVVAKLATFLGS

-----------------------------------------V

PF00225 // ENSGT00890000139327_7_Domain_0 (43, 327)

DSRPDGFGDSREKVVAFG
FDYCYWSVNPEDPHYASQDVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXA
SVGLTP-RICE-----------------------------GLFVREEDYAQSSSSCRIKV
SFLEIYNERVRDLLKQSDPKKPFSLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATQVHEASSRSHAIFTIHYSQXXXXXXXXXXXXXXXXXXXXXXXERANPSYCK
DRITEGANINKSLVTLGIVISTL-GIC---------------------------------
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--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVELDGKVAKIRNLKVNCLG------RRTTMTFS
LL--------------LLLQVFQDLGMEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTP-
----------------------------------------GLFVREEDYASLPSSCRIKV
SFLEIYNERVRDLLKKSGQKQSCTLRVREHPEMGPYVQGLSQHVVTNYKEVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSSLSLNSSA-SNGGDSGIPSSTSGTSSG
GGPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPQVNEDANVKLIRELREEIERLKTMLLSFELRNF-SSLNDEKDEDLKELVFQNELK
IDQMTKDWTQKWNDWQALLEHYSVDIDRRKAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRSDSDQEQDIVLQGQWIERDHCTITSACGVVMLRPARGARCTVNGKEVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5677)

GKAQKFRFNHPAEAAVLRRR-RQVGEAVGGS--GSLEWLNLDGDVTASRLG
LYPLLWK-KRRVLEEQCDEDHQAPRDGETSHRAQIQ--QQQCFVNDLREQILAGQIRAEK
ELKFDQAYISQQIKENQQWLLREETWLASLQQQQ-QE--DNHVAEK--------EVETSV
APDVWLQTDSETQPSPLVQSQ-KRVVQLQLLRRHALRATERNVRQKNVS--CQLERIIQK
QRLLEAQKRLEQLKALCWLQDDSTQKSPYRVPSPDA--TVPGPQ-HRGRSTNCSSLSL--
RRLC---SQHSPQLHSTWL-----KCITFVFLNLDPSTMSPPVPDPTH----QISDKTPS
EEYLPRAASYPPRTGRLCKNGL-HSSGPGKPCTARGALASRGASAPDTCLTVSPES----
-VGIQEMYRVGKQPQWMVSQSLASWSQSANKLKPRDE-PKTLTPTTQIRRAKGLADP---
-GHIQAGWREEG-NLETHRAS------KRATCSS---------LYPQGPKQAAVHGKAAK
TFR--AEYKPPSPSKASKRHQR--VLAARVRDIAQKSSHLSHGSPLKRQHNDGDLDSMAP
LRDSSPVVFHAREKDNDLSDTDSNYSEDSLSCVYAKA-LNEPLKPEDSQGKKWNLPEPEN
SESDNSQISEDSLAEKEYQSPKDSPGGSHPT-NYG----QPRTRARTSVRGFTV-PSDSV
LLAQAHRSFSMDSLIDAGG--ELGEDQQEEPFLGSAGEIPTETFWHPQNFNLPIVDQ--E
AMHRLDAVDHRAG-ARLDAILPMSSSFHLDPQFQP------------------HYELSES
EVEASCSERANSPQD-MQLSRDS---PLMSMDSWFSCDSKINPSSPPGIVGSLYPSPDMQ
EFQSCDEERTGYWLNIEELEPSGVQTVL-SYSSKLLQGSTELPCSARDE------D----
-----------TTS-ASGTSKLSLWGTQSLL---QPG-----ADGSS--QGRGIPDTAQQ
GSSEVSHNSSVSGVPAASAATF---THVGSTQERDW------AALQQKYLLELSHPGLEA
IEEPRP-----AFLCLEEDS--GSLTQASGKGGDTILPTGPRVSGSLDFNNFPIYLSKIR
RVRAEKEQDSLSAKLEGTSDFFSTSDKEVSYNETYS----ADLESLA-SGSMN--AQVFS
EENKIPNSMI-----ESGEVKQNNLQE-CFQGS-RKPGLMTSSDEYFFQKSACHSTVT-I
ATKADHPPQGWAPLRKNSVIQPRQLSPN--SH-CPLQEEKADCQESAK-EVVERHTNVS-
--YAFPSGPELYLHSAPWNPFPSS-LQPPALETFYVTRSRDALTETALEIPACREARVPS
PPAREAWGFGH-HQVFQNAYLKNNLPVLSQNQNSKIASSQ-WVTA---ERPVDLNTKGVI
RELGKCSGNIK-E-----ESH----------------------NSVYFFVAQNRPFLPST
STRIGEFENQAGILNIKHGL-EALEG---EE-A--------------TSSDSLGS-----
-------------GKLLFLICESEASGEEEQ----------------------------G
QSTVLR-LTQACLEKDMP--GETA----VSLESRSVHHKVSSPVIVAEDES--PMW----
EGKNETGLLGKALHPQDSSEEFKFPGTES-------AHER--FQLVTCSR-ERNP--SEC
K-------E----MLNP--KEEPSGKKQNKRVN--SADEMARLIRSVMQ--LENDILEIE
SKQDKQLHASHTPEINKEFVFQDQ-KDQEKADHILR---PASSGNGLAFKDQPSSPKQTD
DVIFR--DGEAREM--EVISSTG-NW--VQKITP----NPFVSRECVQESRSVRGLTH--
SAELDRSARDVC--DS--------------LGTCTTLRE-----SINTSLHPRR------
------------VKSLARALPLQPRPERSSENDS-EWVKV-----S--VS--HKGQPWDL
GSLEELETM-----KGFQETQTAEHISGS--------------TQEEPKAQGRVE-MAVQ
GGGSLQEEENKMV-STQKLPSPSQ-LYMDTFFSQETVCPLLSQTDPS-TTPP-QDL-GNT
LPLNSPSLPRSCLHESD-AIGISSAD---FVLDPTMLKIHNSP-LVTGVEL-QDQSGETR
SHSPQG-NG------------------------------------GGSFVAHAAHCESVI
ST-------ALGSHRQCGAPES------TEARISARTSP-QDQAGDLRIASMGLSTREGF
ASEAEVAVQKKIR-ASSLRRISSQLEKRVSFSLEDDDDQGTK-ARQK---AEEEAEAL--
--RL----------------SSSTFLAPVSLP----------------------------
-RVPTLEPRLLE-PSVYASMCL-----AILEE----------IRQAKAQGKQLNDLVAGG
TVFPYCETLLELECSSRAAGRPQCTQMD-----------QSVSDGTRNEGEAQGPHGVSL
SAERRH--LSVDKRK--VQA--------TPL-SADSFQPPPNSEIDRG------------
-PQHPMQAVSHATS--ALGKRHCTGEL-KHFLGACEQVTCHSSSFEIIEK--EATRTSSS
ADPLASDSLLSSAAVEG--DRKAISE-----------------------------EV---
----------------------------------VAALSSQAPCNDPGVILC-----GRS
QP-AAWETAEGMLPGSKDSSPEHQKP--RTLDTTYG-----------GGSGNFLETAQG-
EE----------RAQLKSQSVICDAQNSPSLS-SKEDHVQSFEASIGLEEGR-ASPKQGT
VLPGTMRRVEL-----GAPAQQHVKWKGSIVSGQTEA-CG--------------------
ADSKHPR--PT------------------------SFPDQRPSPDPGGVREE-ALCRCRR
ETLDCPVFSGSIEGSRTLSPSRGK-EESRIPCCQSCNSQHV-ATHACSSHSSTLLCCGDS
DLGKETFKTAPHTVHPACVVASTACEMDERRESSSREPDMLLAHDL----EPQDMNMEFR
PTESSTLEPSSMAAVLFPAQGCNSHSA-PDVK-TGFLSHPAADRSSSSVGVPEKKVT---
---EKKAS--TELEVAPFPAGTYSEPLRKFQDSSVGCQNAQVSQ-TKGEPL--ATTREPH
TLNLSERSAESGSVIE-SQHGCLENT-IRCLSENPQIAMESRDHNC-LDPQAKFVARLKH
TCSP--QGD-SPWEEEEQQRDQDS-GGGEDPAQGRN-----TPPSKE-GDLDGRQIMNAG
KE-----------------EVAVAKP-----FSLGFEDPAAVPLGQREAPQPAAQRHG-Q
---------P-RHRCSRPVIAVFSGPEHS-KSSPRPQFSVVSSSRSLQELNLS-VKPPSP
ADEDT-QGPNRLWNPYLRGFSSGKSVL------RTSLKAEDCHEKASSNLD----DGTAD
HRPLKPATPPY---PTYSTLSC-------MPTP---ALVTSWMAGALD--QAQQ-GKPEH
LGVQVRPENWFSQ-VDKGMLHFGSSDIDPSVPPWRPEGPACIGWKQYVFGSAVDVSCSQE
PQGLIPSNVALCSGSTMGNGLEDQNSPFHSHLSTHASARDLTSTSSSIENAQASN-VW--
---SSSFVLGDPHVLTGPEGAAPTLG-PDKRPRP---PGGAG-CLRGESRL--AEGSAAG
PVDEVMLPYQSETDCPAEQ-VRANTFEQGTQTLG-CR-------LHWSCTDIS--QPEAS
AASAP-DLASWASMHSLSLHLSQLLHSTSELLGSLSQPGVAKKEQNTK--RDTLDQAPQ-
-ALMMDGYTQTTVDEGSQTDLASP----------SLCHQ-ASEAKPQGDNVMIFKVLSS-
---DISTMS----------QKRGDIPGASQEREA-EETAWK-MAQ-----PPDLQ-----
-EECTHCRSQSPLTP-SAHLRFQKDPLG--QAHPSVIPPVPDAF-LPPISQPAESCCMAV
GSSSL----GTSHSPGLFPHT-SESIREP--GVQKNL-GPTSTSLVDRASSPILTLSANA
PESGL-PPGSLTPSAPSV----HPLDGHRKLD-SS---PALPP-A--TLQPLMDNYSQTF
DESDGS---QRAK--------TL----ERS-----YGRPFLELRSPRSPRQ---------
-----------SPELQVGLVGQLPQQRQPSTAIAVPS-------------------RLLP
PPPLRR----SQVLADSFVSEEAVS-PEHGPLSNREP---SQWQSRT-------VSPVEP
Q-PTLDFSS-SWGG--L--------RHLSL--CPVSELTV-----------TAKL-QGSA
LSPPQACQPEGLLRP---SSQMYVAPKPQHHGLRDLPVHNKFSNWCGVQDGSSGDLGVTE
-ELGASCDVSS-G----RGAPQP---------PEGQSQDPEWSQR------EQIPLQVGA
QNPSLSMELTEAKLHHGFGEADALLQVLQNGTGEALAPVEPVRSTWE--EICARQ-----
----------KTTIETLRRERAERLQNFRRTRSLSPQKQLSLLPNRDLPSRDLDLPSRRR
EYLQQLRKDVVETTRSPEPASR-SAHPPSDIELMLRDYQRAREEAKVEIARARDRLRERT
EQEKLRIRQQIVSQLWLMLIWPSQEEEKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LPGQLQSPENVG-H------------------VNLPDS--KDTWIGDGRGRPAVRNSHL
ECRRV----------------GYSHLYCCAEPHLLIVGRRASLSSLGTSL---SS-SYQD
LAKHIVDTSVADVMAACSDNLHNLFSGQATAGWNHQGEEQAV---------QLYFKVFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPTLWPLYH

PF01852 // ENSGT00890000139327_7_Domain_2 (5677, 5806)

KPIQTARLHQRVTNSINLVYLVCS
TSLCALKQPRDFCCVCVEAKE------GHLSIVAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTMEGKEITRVIYLAQVELGAPGFPPQLLNSFIKQQPLVIARLASFLGS

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------------------------------------------------------Q-----
----------RQTAETLKREQAERLQNFRRTRSLSPHKGLSLQPNRAFPSWDLDLPSKRR
EYLQQLRKDVVETTRSPESALS-SAHPPTDMERMLRNYRWAREKAKVEIAQARERLRERT
AQEKLRIRQQIVSQLLK-------EEEKLHNLAHSSSPCTS-SSGSLSSGITSGYNSSSA
-LSGQLQSPESVR-D------------------SYLPGS--RETWMVNGRSRSAFRNSHM
YLAGSTLKSSAY-----GHRGSVGT--CCWS--------LSSLSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFSCQATAGWNYQGKEQEV---------QLYYKEFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5785)

MVVQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTKSISLVYLVCN
ASLCALKQPRDFCCVCVEAK------EGHLSVMAAQSVYDTSMPRPSRQMVRGEILPSAW
ILQPVTMGGKEITRVIYLAQVELGAPGFPPHHLSSFVRQQPLIVARLASFLGS

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDDKVAKIRNVKVDSRPESFGDTREKVVAFG
FDYCYWSVNPEDPHYASQEVVFRDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREDDCASRPCSRSIKV
SFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHVVTNYQQVIQLLEAGIA
N--RITAATHVHEASSRSHAIFTIHCTQAILQNNLPSETASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLSSAA-SSGGDSGVPSTTSGASSG
GGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKAMLLNFEL-------------------------
IDMLTQHWTEKRNDRQALMEHYGVDINRKRARVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVILRPTQGARCTVNGREVTASCR
LTQGAVITLGKAQKFRFNHPAEAAVLRHQRLKVGEALGSS--GSLEWLDLDGDVSASRLG
LCPVLRK-ERRVLEEQCDRDQQPSRNSEIPYRAQTE--QQQCCVEALKQQAKEGQSRVKK
ELELDHTHISRQIKDNQQWLHKEETWLASLREIQ-QE--GDCGEEK--------ELEAFV
APDAWLPTVPQTPPSPLVQSQ-KRVVQPQCSPRHTTRATVWNIRQKKVS--FQLERIIKK
RRLLEAQRRLEQLSALFWIQDDGASRDPSWASSSNT--SGPGSQ-RRSRWTTCSSLSL--
QRLG---SRHLPQLHS-------------DFMNWDPSAMSPPVPELTH----QMPEKTLS
TDFI------PPRAGRLGRNSF-HSSRWRKFSPG----------------TVSHKS----
-VSSQEIESLGKQPCQMSSQDQ-----STKKQKARDG-SRTFIPAAQTRCAKGLVAS---
-VNTQTGWQKEG-TCGTYKAP------KETASQS---------MDLSGLEPAAGHRKVVK
TFQ--ADSKPPPSSRASKKHQW--VLAARARDIVKKFSRLPHGSPLKKQPCPGDPDTPAS
FTDPRPIKDPVREEDRDLSDTESSYSVDSLSYIYAKV-PKKLLKPEDLQ-GKWNLPDSEN
SESDNSQISEDSLAGKGHKSLPENSGGEYSMKDHR----HSRARTSASVRGLPM-PSDSS
LCTQKYRSLSLDSLIDPEN-------RQGEPFLGSADEMPTETFWHLQNATLSSVDQ--E
AMDRSSPTNHRMG-VGVNVLLPKSNSFYLDPQFQP------------------PCEQLES
EMEASYSEHTNPLRG-LQLARES---PLLSMDSWFSCDSKVSPSSPSGVIHSLCPSPDIH
EIQPHD-EKPKHWLSVEEAKP--------PGTCKLPHSSTEPPCSS-DL------Y----
-----------ATS-ASDTSKPSVCESQGLL---QPG-----DGGFF--QGREMPDMTNQ
GISEESHNSDMSSVLAPSPTSF---TQVCSISKKDW------AALHQEYLLELSDSGFEA
VGEPRP-----ALPFLEEDS--SSLAEASDK-VDTQLPTGPGLPRNLDFSSFPVHVSKTR
HLRAEKGHDSPSAKVESASDLLSTAER-MSSNGAYP----ADIESLT-SGSIH--AQPYA
AGNVIPSSMT-----EAWEVNRASLEG-CLQGD-RHSVLITSSG----QKRAYHNDDI-L
ATEGDCLPQDGAFLRKNAKVQPGLLSHN--SHQQPLLEEKAASQQCTDEEVAGTHIDAC-
--CTFPSGPELFLHSAPWSSFPSS-LQQPPLETFYVTKSRDALTETALEIPACREAWVPS
PPPREAWGFDHSHQVSQKAHWKNNLPKMSQSQNSKIDSPQ-QTTT---KRPTDLDTGEGT
EELGKHSRNMREE-----ENH----------------------DSAYSFVAQNRQHLPST
RLKACECGNQLGILNKEYNASVHEDE---EG-AS-A------WHHCRVAFNGSE------
-------------SKTLLFICDSKASGEEQSP----------LLPQIQSCGMHSQS-PGA
RSDFIFKIANLDLEKVIP--KETA----VSSKSRSLHCL-SSPVIMAGGRSPARRW----
EGRNETVLLGE-VISKDIQEEFSLPGTQY-------ICER--CHLVMCSR-ERKP--TEY
KANGE-SQE----V-QS--KEEPLEENQNKRVN--NTDEMARLIRSVMQ--LETGILEIE
SKQNKHLHASHMPST--ELVLQDL-EDQEKADHVPK---PESSGEHLCFEDQPSFPIQIK
DDIFE--DSKAREI--EANNGTSNNNTQIQKLTG----SSFRSREYVQTRESESEPSYP-
PPGADRLARDTC--DS--------------LGKGTALRK-----PSNISLHSRT------
------------VRGLARALPLQPSIERPK-KDN-ELLKA-----S--EK--FQGQTWAL
ESLEELEKM-----ESFPESQIVVVPSGS--------------ELEDAKTRG-AEEMTVD
WRGSLQGKKD-MVSSTQKVPTPSQ-HWKGTVFSQEAVSPFYNQTGFS-AALPHGEL-SGT
QPVHFLSFPRSGLHGSD-TKGISSFE---YILEPVMLKTNRTS-LATAAGD-QDHGGESR
SSSPQG-RAS-----------------------------------GDVSTTHTPWGGSVM
PV-------VMRVSGKAVTSDS--TLLNTEDWITVSTSSQEDQEGDFRDTPTGSITQEAL
GSEAEATVQEERK-TSSLDRISRQAEKRVSFLLQEDSNQGEE-ERQK---AEEKSEDQ--
--QL----------------PNSAYLTPMSEL----------------------------
-KGPDPEPLLLPDSSIHASICL-----GILAE----------IRQAKEQRKQLNDLVTKG
TVLPYE-TSQEAEWFSEAAGKPQTQKVK-----------L-GWGSTRNDAKAQRLHEASP
SAVS--ADLLADERK--AQV------------SAGSFHHLPNPETDRG------------
-PQHHLLASPHIVS--ELEKRFCSGKP-RQFCGASGW----SDSSEVIEQRKEASRTKSS
VDPLPSDRLLSIPAVEQ--DGGVGSE------------------------------K---
----------------------------------VSVLPSQ-T-YAPGRILH-----GQG
QL-TAQETIKGISFGGKDSIQGHQ-P--RNLDSTHG-----------GGSEKISVTTQK-
GK----------AVFSECPSVICTVDNAVDLSQSKQDHVQGLDASTGLEETK-ASPKSCA
VHPEAPGNVEV-----EANIRHPVKWKN-VDSGLAEA-CG--------------------
GDSKNPW--ST------------------------PFLDQRPSLHPSGVREE-APGPCPK
E---CLVFERNTGGSRPLG-SYEEAENRTIPCPHLSGSQPTAAVHACCSHSSTLLCCRDG
VLRKGTPWAAAPPDHSPCIVPSRVCEVDGTGESLSP---VSLAHDL----KHK-----CG
PVDNSIPNPPTTPPVSSPAQNCSCLST-SEMR-AGCLTHTFARGRS-VEGSGEE-TT---
---GKKASTAPEDTFPCSPAGMSSEPLRTLKNNSID-ENGQASQ-TMPEPP--AVTQGPR
TLNSN-ESVDSKLVIA-AQSGHLENT--KSCSEKMQPSTKVRGHSC-LAPQVRFVDMLKP
TCHP--KIE-TSWEEEEQQRDQVS-GNSKDHAQVRN-----LVPSNV-GSFDGCQTRDGE
T-----------------------KSSVPQTFFSDFE-------AQTEPSQPAAQTHS-Q
HCSDREQLPRS-HRHLLPVIAIFSGPKHA-RYSPRPKFTVVSSSRSLQELNLS-VEPPSP
TDEDA-QRPDSLWRPHLRGHSSEKPVS-------TSLKTQDYSQKALCNLN----NSSSN
HRPLNPVIPPY---PTSSTVSC-------MPTP---EFMTTWMPGALE--QAHQ-GKTDK
LSVQGMPENWHSQ-MDKEMLHFGSSELSPSVLSSHPQGPVHIGWKQYVFGSAVDVSCSQK
PQFLIQSNMAQCSS--MDNVLEDKKSPFHSHPKTDAQTQDLPNIHSDMENDQSSN-----
-----------------------------------------------ELPL--AGGSAAA
QVDEVVLLYPPEAGCVVGG-ASMNTFEQGTQALG-SR-------HHWCCTDVSV-QPEAR
TMSDS-ELASWTSMHNLSVHLSQLLHSTSELLGSLSHPGVVIKEQNVK--RESLDEAQQ-
-ALRVDGSAPTTVDEGIQTDLALP----------PLAFQ-GPEVKSKEVSA-ILEVMGS-
---GITTVA----------QEKGDVPGVFQKREA-EEAA-----E-----TLGLH-----
-EGSTHDKLQSPPLP-SPHLRFQKADLG--QNFTFMSPPASPDG-SPPPSLRPEESCMVV
NMPR------ISPHSGVSLGA-SESTQEP--RTQKRL-CGSSAVLVDRASSPILTFSASN
QELSN-PLACVTLSAPSV----HPLEDLQKFDDIN---SDLAV-G--DPRPPVDNS-QAT
DGSGDF---QRAESLDREGKSPF----GKS-----SERLLLDTSSPCSPQQ---------
-----------SSTFQISFLGTAPQQLQPKITTGGQS-------------------KLPS
PPPR---------LDDSCVSEKVTS-IEHGPL---RP---RQWQGRTTNKDGGSEFMVEP
Q-PNLDQPS-SPRG--L--------QPLSP--CQISD--------------TTGL-RSPA
VDPPQACYPVGLLCS---GSHMHVAPGPQHYNLGDLPVHNNFNNLYGVQDEPGGGLHVGE
-SLGVRCDSSS-VG--THRPLQL---------SDKYSQSLESLRL------EHIPLQAGV
QKLDLSVELTEAKLHHGFGETDALLKVLQSGTGELLAPQEPAVASSE--EFYTRQ-----
----------KKTIETLRRQRAERLHNFRRTRSLSPQKQLGLLPSKDLPTWELNLPSRRQ
EYLQQLRKHIVDTTRIPEPAPR-LARPTSDIELMLQEYRRAREEAKVEIAQARDRLKERT
EQEKMRIRQQIIS--QLL-----KEEEKLQTLANFSSLYTS-SNGSISSGVTSGYNSSPA
-FSGHLQSLEVSE-D------------------SQVPDS--QDTWIGDWRDRSTVRNSYL
YLTGSSWKSLAH-----SRRASMGS--GCCS--------ASSLSSLGTCF---SF-PYQD
LAKHIVNTSMADVMAACSDNLHNLFIRQATDGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--ASVVSQPLSQVWAAVSDPTLWPLYHKPIQTARLHQRVTNSISLVYLVCD
TTLCELKQLRDFCCVCVEAKE------GRLSIMAAQSVYDASMPRPSRKMVRGEILPSAW
VLQPVIIEGKEITRVIFLVQVELGAPGFPPHLLNSCIKQQPLVVAKLASFLR-

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGKIIVEIDDKVAKVRNIKVDSRPDSFGDSREKVVAFS
FDYCYCSVDPEDPQYASQDVVFQGLGTEVLSGAAKGYNVCLFAYGQTGSGKTHTMLGTPA
SLGLTP-RICE-----------------------------GLFIREEDCASLPSSCRIKV
SFLEIYNERVRDLLKQSDKKKSYTLRVREHPEMGPYVQGLSQHVVTSYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYSQAIVENNLPSKIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVSSSCQSLSSPT-SSGGGDNGTPYTLGTSSG
GGASRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IVNKPLVNEDANVKLIRELREEIRRLKAMLLSFELRNF-NSVNDKENENLKELVLQNELK
MDKLTNDWTQKWHDWQALMEHYSVDVGRRRAGVVIDSSLPHLMALEEDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVILRPAQGARCTVNGRKVTASCR
LTQGALITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFSHPAEAAVLRQQ-RQVAEAIGSS--GSLEWLDLDADVPASRLS
LCPLLWK-ERRVLEEQSDKDHQPPRDRGTSYRAQIQ--QQQCCAEDLRQQIKAGHIGAEK
DLEWDQAYTHQKIGDNQQWLFREQQ-----------Q-EDDFGAEK--------ESEASG
TPDTCLQTDPEAPSPPLVHSQ-KRLVQLQLSERRAPQAVEPNIPRKKAS--LQVDGFIKN
QRLLEAQARLEQLRALYWLQDERTQQSLCWIHSSDS--TAPQPP-SGSRWTHCSSLSC--
QRLC---SEHLP-------------PLHSAFLNWDLSTVLPPMPDPTQ----QVSEKIPR
ADHVSSAAACLPRTRCLHKSDR-CPSGQGLLCMA-----KKDTLAPGTCLTVSHKS----
-VNIQEMETVEKQLSQMVSQGIASLCQLPNKLKPRDE-PKTLTSTTQTRRAKELADS---
-GNTKAVSQKEG-NFGANKAA------RGTSYSY---------SYPHGPKQATGHGRVAK
TFQ--MKSKPPFPGRESKRHQR--VLAARVRDIAKKYCHLPHGHPLKRHHNVGDPDATAS
HTDSSLVMDCARGE-DDLSDTDSNYSVDSLSPVCAKA-LLTEMLMPEDPPGKWCLPESEN
SESHNSQISQDLLVDRGDQSL---KGGSHPINKYS----HPRSRTKASARIFPT-PLDSG
LLARAHRSFSLDSLVDAEE--ELEEDLQEEPFLNSANEMPTETFWGLQNSILPVVDQ--E
AMCRPGPTSHRTG-VGLNTILPMSSSFYLNPQFQA------------------NKEWSES
EVEARYPEQASSLQG-TQLSRES---SLVSMNSWFSCNSKINPSSPPRREGSLCLSPVVQ
EVQPFDEERLAYMQNSKELKPLGTEAVP-PDSSKWPRGSTELPCSTGDV------L----
-----------TTS-ASSISKLSFWGTQRLL---HPG-----ADDFF--QGSSSPDTTQP
GNSEVSNSSVLS-EPTTSATSF---TRVGSTHEGDW------AALQQKYLLEVSHPVLEA
VRQPRP-----SFPYLEEDS--SSLVENSGKGRDSQLPVSPGTSSSLNFNNLPILLSKTR
CLRAEKEQDSLGAKLESASDFFCTSEKEVSCNGAYS----ADLESLA-SGSTN--AQVCA
TENKITYSLK-----ESREVRQKSLEE-CCQDS-RKPGVMASSDKYVFQKNAYCRNVT-Q
ATRADHRLQGWSPLRKNSAVHQGQISHN--NC-YPQQEEKACCRESSE-EVVGRCTDIS-
--FALPSGPEPYFHSAPWNPLSSS-LQPPVLETYYVTKSRDALTETALEIPACREVQVPS
PPPREAWGFSHDHQILKKTYLKNNLSVLLQSQNSNIAFSQ-QATA---ERPVDLKTREVS
DELGEYTENFK-E-----ERH----------------------NSVHFLVAQNRHFLPFT
GTEVCELEKEVQILNKKHSLPALTER---DE-GP-A------LSCWSVSLDNSEP-----
-------------EKPFLFICDSEAGRKEEQV-------------QIQDHDVSRQFLSAP
MSDFICKTTDSGL-KDMP--GETA----IFLKSRSECHRVSSPMIIAQDESSTHKW----
EGSSETGLLGETVHPKDTPTELKLSEMRC-------TCER--VKSITCYQ-ERSP--SEC
QGPEG-SQE----MLNS--KEELLGKKHYKGVNNNNADEMAKLIRNVMQ--LENAILEIE
SKQNE-LHASHKARVSEDIMSQDQ-KDPERSDCVLS---PRSSGKHLSCKDQPSSPRQAD
GIDFR--DSEAGGT--KDNRTTGNKNQ-VLNVSP----SPFTSGECVQHSQSVVEHALP-
-DGLDRFPRDTC--DS--------------LGKGLPCRE-----STNTAFHQKR------
------------MEALSRAPSLHTQLESSGMGD---RLVS-----A--LAS-FKEQPWGL
GSLEALEAI-----KGLQEGQAVKYISSS--------------KPEWPRAQGGLEEMTLE
MGGSPQDKSN-MVSLTQKHRSPSQ-HCICTYCSQETSFPLLSKTDFS-TAPSNRDL-SAT
WSVPSPTLPESCLHTPD-MIGISSVD---HVLDPTILKISDNP-SEHEVEY-DSK--RRE
DRSMQG-DTR-----------------------------------GGSSMAYTAWYGDVR
PM-------VLGLYGQSDAAKS--ISLGTEERITAN-IP-LDRGGYLRITSMGLHAQESF
GNETEAAVQKEIR-G-TFLNTASRLEKRVNFSLEEDDDQGRG-AKQK---TQEEAKDQ--
--SP----------------TSSTCSVPVSLP----------------------------
-RAPSQEPLLLE-TSVHASICL-----AILEE----------IRQAKVWRKQPNDFGAGA
TVLPYYETSVEPECSSGTAGRTHCEQTD-----------QLMPGSTRNEDEAPECDGASL
SAAAGHL--LAVEKK--GQI--------TPL-YTDGSGPLPSPEMDRA------------
-PQPLPQSSSLAAP--TPGTKSCTGDL-RDFQGARKEFTDHSISSEITEKKKSCRILSSG
SPLVLD-RLLPSRAVEV--DRVVRSE-----------------------------KA---
----------------------------------VYAESSQAP-QDPGLILH-----GQS
QL-ATWHTAEGKPPGSCTSSPEHQEP--ETLDTTYG-----------GGLCNLLVTAWG-
GK----------TAHFESQSVICGVENSLSFSGTKQDHVQCFETSTGLEKVR-ASPKQA-
VLPGAPRNAGL-----EAPLQQCVNWEENAWV---------------------------R
TGSKNLR--PT------------------------PLLDQRPNPDPR--EDE-APCRGPE
KTRDCLVLSGNTQGTRAVSTARETEES--RTCQLLCYPQTT-AADACSSHSSTLLCHSDG
DLWTN-SKATPYPVYPPFIVHSRACEMGEIGETFSKEADVLLAHSR----EPKGI--DLG
PIDGSMLEPSTAAAVRLPAQGHSSLCT-SCVR-TQSLTQSAADGSSKKVAGTE-EVA---
---ERKAS--RELEAAPCLADPYSEALKNLRHHSVGGHSAHVSQ-TKLEPS--AETQGPH
TLRLREGSVENE-------YGCLQN--IRCLSEKPQHSTKSRD------PPVKFVA--KH
ICST--QGG-SPWEEEEQRRDWAS-GGNEDLPWDRS-----PPLTEQ-VGLNGCHIRDAG
RE-----------------EVVVTKSLVSQTFLPGFEHPASVPLGHGAVPHPADQRPG-Q
LFSNAEQLTP-YSRRSLPMITVFSGPKH-SKSSPRPQFSVVS-SRSLQELNR--VESSSP
PDEDA-QGLHRLWNSHLPGYSAGKMVT------GTPLKTEDCNSTASSNQN----SGPTD
HMPLKCATPPY---PLSSTVSC-------MVTP---NLMNSWVSGALP----PQ-GNPEK
LGVQVSPKNG--Q-EDKGM-YLGSSDTNPCIVPWCPEGPVHIGWKHHMFGGAVDVSCSRK
APGPIPSNAAWCCS--TDNSLRDQNPPVCSCLHTYAQTHYLSSTHSSTENLQGSNEAWNI
GG--VSCALGHPHILSG----------PHKVPQFKGPTDEAG-CLKSGLPL--AEGISVG
AVDEIVLLCPSESGCPLAQ-GKTDTYEQGTQTPG-CE-------LHQSGADVFSPQPDTS
VASPC-GLASWASMHSLSLHLSQLLHSTSELLGSLSQPGVAK-EQNTK--MNPTAGALQ-
-ALRMNSATQTSVEKGSQTDGASP----------PLHFQ-GPEAKPQEVSV-ILEVLSS-
---DITPVS----------QEKGDVTGPLGRV-A-QEMAWK-AAM-----PSDLH-----
-EESAHCTLRSSSVSS-SYLRFQKAPLE--QNLPSGSHPASLDASSSPSSHPEDSSCVVV
NSPSL----SMSHTPGSFPRA-SEPTLEP--QVQKKP-CPTSTLLVDRASSPILTLSANT
QELGLPS-GFF-PQAPSA----HPSEGHPKLD-FT-------------PRPPAGNCSQTT
HDLTIE-------A-------VD----QGG-----SRKSFLELSPRCSPTQ---------
-----------SSSIQVSFLGQPLKQRWPRTTTG----------GQN---------TPSL
PPQSHL----SQRLADSCVSEGMTS-PEHGPLSSR-P---GQWQGTPEHEGKSSIPPVEP
Q-LTVDLSS-WKGP--Q--------H--SS--CPGAEPTD-----------PTGS-RGST
ADL------PQGVYP---SSQMCMGPESQPCNLRDLPVHNKFSNWHGVQHDSSEGLGVSE
-EIEASSDLSS-GEQRQ-GPPQP----------GDQSLDPEWSPR------KRISLQVGA
RSTPLSVELTEAKLHHGFGEADALLLVLQRGTGVALVPDEAVMSTWE--QRHARQ-----
----------RQAIEILKREQAEQLQNFPRTRSLSPQKKMSLLSNRAFPSWDQDFPSRRR
EYLQQLRKDVVEITRSPQSAPS-SAHPPSDIERMLRDYQQAREEAKVEIARAQERLRERT
TQEKLRIRQQIISQLLRM---RSGEEEKLHTLACSSSPCTI-SNGSLSSGVTSGYNSSPA
-LSGQLQPPESVR-D------------------SNLPDS--RDSWIGDGRSCSAMRNSHL
YMARSAQKSSAFSEWWAGRRGSLSS--CCCS--------ASSLSSLGTCF---SS-SYQD
LAKHIVDTSMADVMAACSDNLHNLFIRQATAGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVAQPLSHVWAAVSDPTLWPLYHKTVQTARLHQRVTNSISLVYLVCN
ASLCVLKQPRDFCCVCVEAKE------GHLSIVAVQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVKGKEMTRVIYLAQVELGAPGFPPHLLSSFIKQQPLIVAKLASFLGS

------------------------------------------------------------
--------------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (87, 419)

TEVLSGAAKGYNICLFAYGQTGSGKTYTMIGTPA
ALGLTP-RICE-----------------------------GLFSKEDGYSNSPSSCRIRV
SFLEIYNEKVRDLLKQPDQKKPYTLRVREHPETGPYVQGLSQHVVTNSRQIIGLLEEGVA
N--XXXXXXXXXXXXXXXXXXXXXXXXXAVLENNLSSEIASKINLVDLAGSERADPSYCK
DRITEGASINKSLVTLGIVISTL-AQNSQMFISYQSPNSTS-SEGGDGGSLSSPSVAGSI
GGVPRKQSYIPYRDSVLTWLLKDSLGGNSKTIMVAS-----ECLGSAP----YVRAM-SG
PEDGP-------------------------------------------------------
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----------------------------------MPKVQMSCLWLEA--VLQLWQ-----
----------KKAIETLRREHAERFQNFHWTRSISPQKQVGLLSNKD-------LPSKRR
EYLQQLRKEVVETTRSPEPASR-SAYLSSDIELMLRDYERAREEAKVEISQAQDRLRKQT
EQEKLRIHQQIISQLLR-------EEEKLQTLANSSSLCTS-SNGSLSSGVTSGYNSSPA
-FSAHLQSSEGVE-D------------------SHVPDS--RDTWIGDWRARSTVRNSQL
YLTGSTWRSLAY-----SCRASMGS--GFCS--------PSSPSSLGTRF---SS-SYQD
LAKHIIDTSMADVMAACSGNLHNLFSRQATAGWNYQGEEQEV---------Q

PF01852 // ENSGT00890000139327_7_Domain_2 (5633, 5806)

LYYKEFS-
-STRHGFLG--AGVVSQPLSHVWAVVSDPTLWPLYHKPIQTARLHHRVTNNISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPSRKMVRGEILPSAW
VLQPVTMEGKEITRVIFLAQVELGAPGFPPHLLSSFIKQQPLVVAKLASFLGS

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--------------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (87, 406)

TEVLSGATKGYNICLFAYGQTGSGKTYTMLGTPA
SMGLTP-RICE-----------------------------GLFIREEDYASLPSSCKIKV
SFLEIYNERVRDLLTKSGQRKSYTLRVREHPEMGPYVQXXXXXXXXXXXXXXX--XXXXX
XXXXITAATHIHEASSRSHAIFTIHYTQANLANNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQGLSSCQSISCVASSRG------------TSA
GRAPRRRSYIPYRDSVLTWLLKDSLGGNSKTIMVASKWAAGAGSLELLASVSS-------
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--LINMKKTL

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RMRPLDFREHAEGRRIIVEVEDKVAKVRNIKVDNRQENLWDTKERIVAFG
FDYCYWSVDPDDSKYASQEVVFQDLGTSVLSGAFKGYNICLFAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFLREDDYTKQSASCRVEI
SFLEIYNERVRDLLKQTDNKKPYTLRVREHPVMGPYVQGLSKHVVTDYKQVVGLLEAGIA
N--RITAATHVHDASSRSHAIFTIQYTQAILYNNLPSEITSKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISSL-AQNSQMSCSCQSINSIG-SEVDSSHTDNHCGT---S
ISSNRRQAYIPYRDSILTWLLKDSLGGNSKTIMIA-----SSCYNETMSTLRYASNA-KN
IINKPRVNEQ-------------------------RNASPSWSDDKEGNLTELVLQNEIK
IEQLTKDWTDKWINKKAIMEEYSVDINKKKAGVVIDSSLPHLMAMDDDILSTGVVLYHL-
-------------------RGQWIKKDHCVVDNQHGIVTLQPLQEAHCIVNGHEVTDSIR
LSQGAVIILGKAHKFRFNHPAEAAILRQR-RSVSDS-SVVNCRSLEWLDLDGNFSS-LSY
SFSPPET-KSEQREAVHEECHLKRKNQAILQKREIL--QQQLYVEELQQQIFDGEIKAAQ
ELEHDQVIINQQIKETQQWLIDEKKRLI--SQQQ-----RECAVQT--------EVKSYA
EAGIQNILESEIGPSVTEQNK-KKLVQLELLRKYSLRKAERHLSRKKVK--LHLERIVKK
QKLLEAKKNLEQLEASCWISEDNTNQMNFQ---LIKPSSTSLP-----------------
RLNC---NNTLSSCYCLWGLPITWKYFHSLFLKRIPLGYLPQHPE---------------
--NLPKTLKSLSRRDYSHDERDDSFTTQKQIIKNQKILYF-GNKGIVKNNSTNTDILSLI
CKNNQTMEKANNRPRQTRTKSQVPKNSSPDYFKRKCE-PETAKQGTKA---KTSGDS---
-NRHSEKHLEKGEALEGSRKFKRDKRKKIQSSLPGNSTKEFKKSTVSEKPPLQHLSQISK
NV----------------------KVATSARSLTNISTSTSLCRGEKRWHSAEMLSVGIS
KGVHGPLRSWQEDEDAEFSDTDSNYSVDSLSCGNAKI-LTEALTREEESVEM-DTVNLED
SESDDSQMSQDSLTEKINKTESENVKHFPEVHKE--ETKFHKENDLKPLSLIPNTSLTNS
NLTMNERSFSLDSLGDVDD--VSGEEVTEESKLESFDEVPAELFWKMQNLCSESIKS--N
KQHNLEQCNETVI--SDDLNLN-TSSFFLDASAQP------------------SSSNIC-
----------------DQS-IIL---AD----AWLSCDTKNGKSSPIIAMPSSQDHTEFR
VTELHPVNK--PWMKRDDLRQSAAELSF-VSCYEKPYRVPHEP---NNIKM---------
------------LL-SSATPSVPLPETRKYVEIEALGAISSFSLSTF-------------
----------------SRKHSY---CEVASSLE-----------SVCQQSNDFS--EHKS
TDEWKQ-----TSSSLKETSRTNSSSQVSLGQGISVSSVYPEISKDQDLKNNSLISVLST
AS-SQK--GEVYLNTNFEECLFRTIEKEDESDSN-STKD-TKILELN-HEEKL-FSPLPD
GFSDLTS-------MLSPKSSYKDREH-LF----SNDKTTLISDESFYLSDILGNHTHSV
NDV--------GKYSA--DQLY-MMRLD--ES-NIEVVQKTKCQQLYA-DNQLYDTETTA
-------------F-QHSDQLPLS-VETSETEKVSIQENRDVLTETALEVPSFREAEEEK
-DKCEEWCLENDFKVHTKPLLTNSCAGLKAVSSE-NSFSQ--G-K---------------
ESSDLCVFFNN-S-----GKVLRNDGIV--STMASQEQNLSLNKVSRY----EKERVVSI
ALTACEDS----------------------K-SE-H-------NRKTINS----------
--------------EELTKLI---------------------------------------
--NSVN-----KLEFDI-------------LEM---------------------------
------KYNQN-----KCLRNFLGVESQSLNADNTGTFENDS--LAQT------------
-----LDGDHEK--------------------------GVTNLLTTVTHEEIDKERIQLI
S----VNKE--KPCVSKTAMETDK-NIETNS--INYHEVQGNSTENSCLADIKPDPI---
-------------------------AQTLEKVLCYESRAATESTECRQD-NTLNSSEE--
-----DETKSIT--NE--------------TSLIESLMT-----NPKT-AQEKN------
------------IDGVNIDSQSVDVERTVAAKN--EKYVK-----S--------------
--------------ES--------------------------------------------
-TELYT--DK-NVDLFQENPGHVF-----------------MNPNNDIERTNQCDTESQE
TNSTAFKLEEKQ--------GVPQLVEAACLCAEEAYDDNRSTSICTHMGSINE---TLD
NSNDSG-SDGCRAV-----TTQCRISEEFK--------------TEENINKYKSSC----
-T-------NYLANTMSEHPDLNLVEVDVSKCLPSNYVP-KEKGTIHPVMQVKLATTEIL
GQSV-----------NVQNSSTFKTENN-GR---------------NLKENSGNLENKC-
-SN-----LFTEVLKEDEWVPHSFSQNNASIIDN-----------SIL------------
AGHMDPPQSTNK-DSDLSSV--AVKNFPYPEINRNEGNRKRSPPVTSSPTMPSSNYISSE
IFLQYYETHMDSELEAEILCANTVEINDSSNIIIQNKYVTFLPDQMSKGKEHLASEIATF
T---------T------PEQ--------SPV-KDDGCSKSCATEFHESLAVADIAQN---
KAIALKKLLSPGNTSSEMGR--FHSEFNRGEQRQSEECL--K-TLNIYQKERSDCLILGK
----TT-PPLIFG----ENNEDIISSLPELSTQDCFNNVMSQKEHYDQTQKCP-DNC---
----TEAECKRRSQKFTGELESQAETTEILVSKHLLDLCEGHSSDTGATSED-RANLSGH
SDQALWENAQYSE--------GNAS---GYNMNSYISEYSAGDYDSSTSLPHFLLKHRI-
DEYNADDLYFEESQYLDPQNVDIPVGT-VGVCVPQ-------------------------
--------------------QQNSKITSDTDCTTSIQTSIVLK----------------T
VGTLESSTSPD------------------------FLTSSVC--RPYI---------DSH
DAFLTPSFSTSFRG-----PES------QVIPDTTCL----------SSETSHSYDMSHS
ETERDTILYAATASSPSLS----TCQMQESQCDNFDILDQQLCASESTSFSLTKENPCLS
VCDIEDNSQRSSGKCTFKSEQIFQES--------GVHH-----E----------------
----PRNR--A-------------LLQKSFSED--------------------SGKSLYG
TLN-SVHDIEGDQNRS-H-------------------VDDQSD----IV--NVPTTNTDS
NCAYEVLKNKTA------------------------------------------------
-----LFTANQPNISVI-NNSMSSKYLSENSCLTLQEEPASERLGKDN-IVLTSQNTTKS
KDNKQRPGLH-SHSLSAPTIVVIPNSEFASETS-KTDFSVHHASKSLQELNMS-VQPPSP
TEDNM-HKLESVSKLKTGSVIPIKYKPRFQRKSIQAQHSSHCDKRNVRERILGSYS--TD
LSPV---RHPV---AVTL--------TTDNPID---TEIRKCSNNANSIHGYNI-GENEG
LRHQMEATDKLPQ-DNRDAMHFSSSDINPYIHPWQQDEPCKIGWKQYVFGSASDVSSNPP
PLSLDNQMAMRCSS--VDNGLNSQNSPFHSHLSSYANARVLSSTISSTEDLQEWDIAREG
FE--TAHLDENGKHFSNVSHDKLETT-PKK----SCISHCENVVPGVRCSQ--QSGNTPV
QVDEIVLLYPSKSEISSSKSHTVLTCEQETQTEA-PSKHKRQKRHRRSYTDLSARKIDSG
NSSVQ-HPSSWLSMQNLSMHLSQLLHNTSELLGNFSVQTAKDNEH---IGHKATEESTR-
-GATSDNSTQTTEDIGIQTDIFGHFQNEIKERHINTNVE-SDPAKSQEVNI-IVKLMHS-
---DTKERTP---------ENTGRILQSMPDI-----RSYH-TDT-----TEDSCKSTLK
KNSNSPSEVPKIPVNVPPAVVL-------------GGSKNYPIASSSK-HESTIGNCSAS
---------TLSLSPEYYSQD-KRLAAKTSSAEAREL-FPKKSLLVDRASSPILTLSAST
INYQSLSDT----------------------------------------------SSQTE
VESESTTS-RESNEMCKISRNVL----DKN-----TAKELD--SKSFDNSKNHRFTINTH
TAVHTKRLYHSSSTLELSSHGDYLVDDHRETIPVEHSFC---------------------
---------QIQRIKDGLNYDNLTR----NSESSSV------------NKSIRKSLSEQH
T-PSLLKND-WATDCTFDSFSPQFNKRHKK--CPFTMSEMGDMQ----DNNVDDDTRSE-
--TESECNTEILL---GENTSLMKTQRHRSYSLRDLPLHNKFSNWCGVKGGPHSSLITLT
---QSANDIHS-QEERKTMSTTATETEERFLLSERRAREIERLRRERAQIMSGVHLN--M
NPPPLTVELTEAKLTYGIGETDAQLRILQSGLGEDLTA----MPIKQ--QLYERH-----
----------RKSIEILRKQREERLQSFRRSRSLSPQKHLSLLQTLDTNQRDVDLPSRRR
EYLQQLRRDVVENTRVQEPKMR--LQHPSDIELLLRDYQRAREETKTEIARARDKLRERA
EQEKRRIREQLHSQLHK-------EEVKLKTLASTSTLCTD-STLSLSSGPTSGYNSSNT
-ATSATSIVGKQEYQ------------------INQISPEDIEQSREGGRGRSAVRNHQL
YILEQWQKGSSC-----------------VF--------LCS-HLSLSTFPASPMKEYED
LSKHVLANATAEVMAGCSNDLKNLYNGLATAGWKYQCVEKDV---------LIYYKGFSS
CATKHGFLG--AGVIKRPLSAVLSLLKDASKRHLFDKTVTTAQVYKKITSNIELVYVVSD
VSLCYQKQPRDFCCISVEARE------ENVCILAIQSVYEESMPHPCKEIVRGEILSSAW
ILEPDTVNGKDVTKVVYMIQVDLGPPAIPASLLSSVAKRQPLVIARLAHFLAG

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 422)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVVAFG
FDYCYWSVNPEDLQYASQDMVFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRKEDSAPLPSSCRIKV
SFLEIYNERVRDLLKQSDQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENSLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQAFSSCQSLSSAA-SDGGDSGIPSSPSGTSSG
AGPSRKQSYIPYRDSVLTWLLKDSLGGNSKTIMVASE-------CETMSTLRYASNA-KH
I

ENSGT00890000139327_7_Linker_0_1 (422, 559)

INKPRVNEVRT-------------------S-FETNY-SPLNEEKDENLKELILQNELK
IDQLTKDWTQKWNEWKALVEHYRVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHL-
------------------

PF00498 // ENSGT00890000139327_7_Domain_1 (559, 610)

-KGQWIERDHCTITSACGVVILRPAQGARCTVNGREVTASCR
LTQGAVITLGKAQKFRFNHPAEAAVLRQR-RQVGEAVGGS--GSLEWLDLDGDVTASRLG
LCPLLWK-KRRVLEEQSDKDHQPLRAGEAPHRAQIQ--Q-QHYVGDLRQRILAGQIRAKE
DLELDQAHISRQIKDNQQQLLGKETWLAGLQQQ------RDYVAEK--------ELEVCV
PPGAWLQADPETLLPPLVRSQ-KREVRLQLGRRIVLRAAQRDIRRRKAS--FHLERILRK
QRLLEAQKGLEQPKALCWLKDDHAQKPPYWVPSTDT--MVPGPQ-HRSRRAGCSSLSL--
QRLC---SRYLP-------------QLHSIFLNRDPSTMLPPMPDPTD----QISEKIPS
EEYLPQAASYPPRTGHFSKNAL-YSSGKRHLCTPKVALARNGALASGSCLTVNSES----
-ASIQEIQRVGKQPCQMVSQSLASLDHSANKLKPRDE-PGALTPSTYTKRGRGLADP---
-DHTRAGWQKEG-NFGTHKTA------KGTCCTS---------SHPRGPKQASGCGKAAK
TFW--VESKPPPPSQASKRQQR--VL---VKDIAKKSSCLPHGSPLRGQYSVGDRDSTSS
LTDFSPRVDHVRDKDGDLSDADSSYSVDSLSCVYAKA-LMEPLKPKDPEGKEQDLPEPEN
SESDDGQISEDSLAEKGYESPPDSPRRSYLPSGHG----HCRARVRASVRAFTT-SSNSG
LFTQTQRSFSLDSLIDAKE--ELREDQQEEAFFSSADEMPTETFWHLQTSNLPTVDQ--E
ATYRLGPINHRAG-AKLDAILPMSSSFYLGPLPQA------------------PC-----
----------------LQLSRGS---PLLSMDSWFSCDSKINSSSPSGIVGSLCASPDIQ
ESQPHGWERPGHWQNMEELKPSGAETLL-PYSSKLPRGGAELPCRVSGV------Y----
-----------TIP-ASDTPRLSLSGSYRLL---QPR-----VAGIF--QARGVPDTAQE
ASSEASNNSSVSGVLAASAASF---THVGSAHERDW------AALQQKYLLELSHPVLQA
VREPRP-----TFSSLEEDS--ASLTQASGKETDTLLPVGSGVSSSQDFSNFPIHLSKIR
HLRAEKEQDSLSAELEGTSDFFTAREKEVSHSGTYS----ADIESLT-SGTTN--APVFV
AENKIANSMT-----EACEVKQNSLEE-SSQSS-GKPRLMTSSDECFFKKSHCHSHVT-I
ATKENHWPHGGAHLRKNSAGQEGQFSPS--LY-PPLQEEKVDYQESSR-EVVGKHPSVS-
--FAFPSGPKRYSHSAAWNPFPSS-VQPPPLETFYVTKSRDALTETALEIPACRESRVPS
PPPREAWGFGHDHQVLQNIYLKNKLPVLLQNQNSKIASSQQGVTA---GRPFDLNTKEVS
RERGKYPGNIE-E-----ESH----------------------NSVYFFVAQNRHFLSST
STKVCEFENQVGILNKH-SLSALQEG---EK-AT-V------QSYCNVCSSHSRS-----
-------------RRP-LLICESEADEEEEQDH-------NVVLRQ--------------
------ETINLALDKEIL--GGTA----ISLQSRSVHRRVSGPKMMAPDESPAHKS----
ERKNESGFLGKALYSKGSSKEFKLPQTET-------TYER--FQSVTCSQ-EKNL--SEC
KGSGK-SQE----MLSP--KEEPSGKKQNRRVN--SADEMARLIRSVMQ--LESGILEIE
SKQNMQPNASHTLGVSKEFVFQDR-MDQEMADYVLK---PDSFGNHLSLKDQPSSQKQTD
DVTFR--DSEAGEM--EVNSSIGKGPQ-VQKITL----YPFKSRECVQDIKFAKEHTCP-
-AVLDRPSWHMC--DD--------------VGTCAARRE-----FADMCAD-PR------
------------TKGLASGLPLQPSPKMSSEKEG-EVGNA-----S--AS--PRGQPCGL
GSLEELKTM-----KSFWETQVANCVSSS--------------KQEEPKVQGRVEEMAVQ
RGGSLQEQNT-VVSSTQKLFSPSQ-HCMGTSYSQET-GPLLSQPGSS--AVPHGDL-SST
LSLNSSRLPRDCVHAHD-TVGISSVD---YALAPTMLKMPNSP-LVTGAGS-QNQSGEPQ
GHSPQG-NVR-----------------------------------GGSSLAHSAWCGSVI
ST-------AMGSHGQSHVSES--IPLEAEGHRSV--DM-QDQGGDLRSISMGLSPREGF
ASEAEADIQRGTERTRSLNRVSSPLEKKARCLLEEGHSQGQQ-VKQK---AEKEAEDL--
--SS----------------PSGTFSAPVSLP----------------------------
-GVSHPEHCA------HTSTGL-----AVLEE----------ISQAKAQGKQLHDLGAGS
KILPYYETLLGPECSSGAPSRSQCPQRD-----------QLVSDRASNEAEAQGFHVASL
SAQPGHL--LTNERK-VPQA--------TPL-PADSFQHPPKTETKTG------------
-PQLPSQNSSPAAP--TPGKSHCAGEL-RHFLGADEQFVCHTC-SEIIEKKKKATTTPSS
SDLMGL-GSFPST-TVE--DRREISE-----------------------------KV---
----------------------------------VAPLSSWAPNDHPGMIPH-----GGS
QL-ALWETAEAMRPGGQERSPMHQEP--RVLDTTCG-----------GGSGNFLVAAQE-
GK----------TTYFESQLVTCDVQNSVSLSACIQDSSQCLEASTGLEEGT--------
ILPRALRSIEL-----EAPLQHCVKWKENVGCGLAEA-CG--------------------
AG-SHPR--LT------------------------PLPDQRPSPGPGGVQEE-AQGRCPQ
QASYCVVFLGNIESSRTLSPSRGPEGRT-TPCQHLCNPQPI-ASLACFSPPSTLPCYRDG
DLGKGSSKTALHTLQPPCIVPSRACGMDERGEGCSGEPEVLLAPGL----EPKGIHKDLG
PTDSSTREPSASAAVLSLAQGGSSPSA-SHGG-ASSLSHSVADGGSRSVEDPEKSAA---
---EKKAS--TELEAACSSAGMCSEPQRMFRDSPGGGQNARETQ-AKPEPP--LTTEIPH
TLDLSEGSVESELLGE-AQHGYLGNA-MQCLPEKLQLSSKSRDHSG-LDPQARFVAKLKH
ISRY--QAD-GPWEEEEQQRDQES-GGGEEPAQGRT-----SQPSHE-GGLDGCQIRDAG
RE-----------------EACAAKPSVSKMFSSGFKDSATMPLGQSGAPWPTPPSPG-L
PAFGREQPAL-PNRCSLPVIAVVSGPRH-SRSSPRPQFSKVSSSRSLQELYMS-VEPPSP
TDEDT-QEPNRLWFPHPTDYFSGNSAV------RTSLEGESCGQKASSNLD----NSTAD
YWLPKPATPPY---PRSSALSC-------MPTP---DFMTGWTSSTLEE-EGWQ-ESPER
PGGQPRPEKWNSK-ADKGTLHYDSSDLNPYILSSRPEGPVQIGWKQYVFGSAVDVSCGQI
PQGLIPSNMAHCSS--MDNGLECQNSPLYFHLSTYANARDLSSPH-SIGNAQGSRKPWEV
WG--SSFAWENVHILNSPEGATPGKG-PDKRAQFPGTPDEAG-WLRREPLL--AEGSAAG
PVDDIMLPYPSEVGGPVGQ-SRMGTLEQGTQTLG-CS-------LCWSSTDISSAQPETG
ALPVS-GLVSWTSMHNLSLHLSQLLHSTSELLGSLSQPSVAEKEQNIK--RETPDEVTQ-
-AFMIDGCTQTTMDKGIQTDLALP----------PLHLQ-APEANPQEVNV-VLEVLAS-
---DIPTMS----------QRQGYVTGTLQKKEA-EETAWK-MAA-----SSELR-----
-EESPHCRPQSLLAPP-SHLRFQKAHFG--QNLPSVSPQAS-DASLPPSSQPEEPSCLVV
GSLSL----TGSQSPEPCPSA-AESRRDP--KVEKDL-STMGMLLVDRASSPILTLSAST
QGLGLPA-DSLSATTPSA----CPLEGHQELV-SS---PDLLP---DTSRPPVDNHSQTT
DESGDS---QRVGAPCGEGRSPL----EKS-----DGRSFLEVSSPGSLPQ---------
-----------SPKLQVCFLEQAPQQLQPKTATL----------LQS---------GLPT
PSLRSR----SQRLADSFVSEDLAS-LECGPVSSRGA---GQWQSKTENGGESSASPVEP
Q-PTLDFSS-SRGG--L--------QPLSP--RPISELTD-----------TSGL-QGST
LGPTKACQSEVLLCS---SSQVCMAPEPQHHSLRDFPVHNKFTHWSGVQDGSPGGLGVK-
---ETRCDPSS-GEQGQ-KPLQP---------PDDQSQDPQWSQR------EPIPLQVGA
QNLPLSMELTEAKLHHGFGEAAALLQVLQTGTGEALAAEEPVRSTWE--ELYARQ-----
----------KQTIETLRRERAERLHNFHWTRSLGPQKQLSFLPNRDLPTQDLDLPSRRR
EYLQQLRKDVVETTRSPGSASR-SAHPASDIALMLQEYQRAREEAKVEIARARARLQEQT
EQEKLRIRQQIISQLLR-------EEEKLHTLAMSNSLCTS-SNGSLSSGVTSGYNSSTA
-LPDPLQSPDSVG-D------------------TNLPDS--SDSWIGDVRGSSTVRNSHL
SLAGSTWKSLAY-----SRRTSLGS--CCCS--------PSSLSSLGTCF---SS-SYQD
LAKHIVDLSVADVMAACSDNLHNLFSCQAAAGWNYQGEEQEV---------RLYYKVFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVTNSINLVYLVCD
TALCALKQPRDFCCVCVEAKE------GHLSIVAAQSVYDTSMPRPSREMVRGEILPSAW
VLQPITMEGKEITRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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--------------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (87, 397)

TEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFLREEDYAPLPSSCRIKV
SFLEIYNERVRDLLKQSVQKKSYSLRVREHPEMGPYVQGLSQHVVTNYEQVIQLLEEGIA
N--RITAATHVHEASSRSHAVFTIHYTQXXXXXXXXXXXXXXXXXXXXXXXERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSVS-SDGGGSGMPSFPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSQTIMVASEWDAGVGSVLG---LVLCHRE-RD
MPG---------------------------------------------------------
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--MANVKVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 422)

RVRPLSKRESAEGGRVIVEVDDKVTTVRNVKIDSRPDGTWDSREKTVAFS
FDYCYWSVDPEDPKYASQEMVFQDLGTSVLSGAFRGYNICLFAYGQTGSGKTYTMMGTPA
SIGLTP-RICE-----------------------------GLFSRKDDYSEQTASCRVKV
SFLEIYNERVRDLLKQSDHKKPYTLRVREHPETGPYVQGLSQHLVTDYKQVVELLEEGIA
K--RITAATHIHNASSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQIFSSCQSINTIM-SEGESSHVDNPSTG---S
VSGSRRPAYIPYRDSILTWLLKDSLGGNSKTIMIATISPASSSYNETMSTLRYASNA-KN
I

ENSGT00890000139327_7_Linker_0_1 (422, 544)

INKPRVNEDANVKLIRELREEIDRLKTLLMSFELRN-SSPWSDDRDGNLTELVLQNEMK
IEQLTKDWTSKWMDRKAIMEEYSVDINKEKAGVTIDSNLPHLMAMDDDILSTGVVLYHLR
EGT

PF00498 // ENSGT00890000139327_7_Domain_1 (544, 610)

TKIGRSDSDQDQDIVLKGQWIEKDHCMIDNNCGIVTLRPLQGAYCTVNGCEVTGSCR
LSQGALVVLGKSHKFRFNHPAEAAVLRQR-RSINDVPPILSCGALDWLNLDGSHTHSTHY
ILSSLQ------KSTFNEEYKKKLKEQEAFHRKQIQ--QQQLYVEDLKQQILKGQVKAER
ELENDQALINQQILENQQWLINESNRLAALQQQQ-----REFAVQT--------ESTLYA
EAEVQSSLALEISPSLLQQNK-KRLVHLELLRRCSLKKAERNIRRKKVK--FQLERIVKK
QKLLEAKQNLEQLEANCCLSEVRVKQSYIPNDQIIPSDSFTRMILPW-------TLKLTN
LLKQ---NTALHST-------------KIRLLNGETISKLSTSPNTDQCSEM--------
-----------------------------QLSEKQKVSSF-GNKKGAERVSNDSAVMAHI
NKNDQKMEKLNDSRGQTGCQKQTSKGSSPDHYKEKNE-PETFITGTRMTKTKVLGDL---
-SQPANSCLEQNRAQVSNKKTRMDINTKGHSPSPENFVNKMKKAAVYGNLASAHPNQAAK
NLEREAPSDLESHENSSVEHQEFLMVATSVGNLTKMNTQAPLSYVEKKWHSAELLSAGMS
KTATDVLGNWQEDEENEISDTDSTYSVDSLSCAYAKA-FTEKLKQDDFHRNK-CLANPED
SESDDSQMSQDSLVEKENKAKKQNKSQFQKLKARYQPAKLYKSRSEHRVSSLVTSYASHR
RLGEAERSFSLDSLGDGEE--VPTEDPVEESKSDSSDEVPAEIFWKLQTPRPQTVQT--E
EGHESKICNRDAE--GTNYNLKLSSSFYLD------------------------------
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--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDDKVAKVRNVKVNSRLESFGDTREKVVAFG
FDYCYWSVNPEDPHYASQEVVFRDLGTEVLSGASKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREDDCASMPYSRSIKV
SFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHAVTSYQQVLQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHCTQATLQNNLPSETASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLSSAA-SSGGDSGIPSTTSGTSSG
GGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPQVNEDANVKLIRELREEIERLKAMLLNFEL-------------------------
IDTLTQHWTQKPNNRQALMEHYGVGINRNRARVVIDSSLPHLMALEDDVLSTGIVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

RIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVILRPSQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5632)

GKAQKFRFNHPAEAAALRQERLKVGEVLGSS--GSLEWLDLDGDVSASRLG
LCPVLRK-ERRVLEEQSDKDQQPLRNGKISYRAQTE--QQQCHVEALKQQAKEGQSRVQK
ELKLDQTHINRKITDNQQWLLREETWLSNLRETQ-QE--GDCGEEK--------ELEAFV
APDAWLPTVPQTPPSPLVQSQ-KRVVQPRCLRKHTSRATVWNIRQKKVS--FQLERIIKK
RRLLEAQRRLEQLNALFWIQDNGTSKAPSWASSSNT--TGSGSQ-RRSRWTTCSSLSL--
QRLC---SQRLSQLHS-------------AVMNWDPSAMSPPVPDLTQ----QMPEKTLS
TDTVPQATACPPRTGCLGRNSL-HSSRWRKFSPARG------------------AS----
-VSSQKIESFGKQSCQMSSQGQ-----STKKQKPTDG-SRIFTPAAQT-KAKGLVAS---
-VNTQTVWQKEE-SCATYKAP------KETTSHP---------TYLSGSEQVAGHRKVVK
TSL--AESKPPPPSRASKKHQR--VLAARARDIAKKFSRLSCGCPLKKQPSAEDPT---S
FTDSRPIMDHVREEDKDLSDTESSYSVDSLSYIYAKV-PKELLKPEELQ-GKWDLPDPDN
SESGNSQISEDSLAGKGHQSLPENSAGEYSMKDYG----HSRARPSASVRGLPM-YSDSS
LCTHTDRSFSLHSLIGPEN-------RQGEPFLGSADEMPTETFWHLQKATLSAIDNRQG
ATDRPSPINHRVG-VRVNNILPKSNSFYHDLQYQP------------------RCEQLES
EMETSYSEQINPLRG-IQLARES---PLLSVDSWFSCDSKVNPSSPSGVIHSLCPSPDIH
ETQPYS-EKPQHWLSSEE-----------PNTCKLPQTSTEPPCSS-DL------Y----
-----------ATS-ASDTSKPSVCGSQRLL---QPG-----VDGFF--QGREMPDMTNQ
GISEESHNSDMSSVLATSATSF---THVRSINKKDW------AALHQEYLLELSDSIFEA
IGEPRP-----AFPFLEEES--SSLADASDK-VDSPLPTGPGLSRNLDFCSFPAHLSQIR
HLNAEKDHDSLSANVESASDLFSTVER-MSCNEAYP----TDIESLT-SGSIN--AQACT
AGNAIPSSMT-----EAWEVNQASLEG-CLQGG-RHSALKTSSGQYFFQKRTYHNHDT-S
ASEVDYLPQDETLLRKNTPVQPGLLSHN--SHQHPLLEEKAASQECSE-EVAGTHIDAC-
--CTFPSGPELVLHSDPWSSFPSF-LQSPSLETFYVTKSRDALTETALEIPACREAWVPS
PPPREAWGFGHSHQVPQKAHKKNNLPKLSQSQNSKIDSPH-QTIT---KRPTDTNIGEVT
GELGKRPRNMKKE-----EPH----------------------DSAYCFVAQNRQHLPST
RLKACECRNQLGILNKYSLS-VHEDG---EG-AS-A------WHHCSVAFNGSE------
-------------SKTLLFICDSKASGEEQSP----------LLPETQSSGTHSQSPPGD
RSDFIGKITNLDLEKVMP--EETA----VSLKSRSLHCRS-SPAIMAGGRSPTHRW----
EGRNETVLLRE-VISKDIREEFSLPGTQY-------TCER--CHLVMCSQ-ERKP--TEC
KAHGQ-SQE----I-QC--KEKPLGEKQNKRVN--STDEMARLIRSVIQ--LETGILEIE
SKQNKQLHASHTPST--ELMLQDL-QDQKKTDQVPE---PESSGKHLCFEGYPSFPIQIE
DGIFE--DNKAREI--EGNSAIS-NNAQVQKITG----SPFRSRDCKQTRGSEREHTYP-
PPGAHRLARDIC--GS--------------LGKGEALRK-----PSNMSLHSRR------
------------MKALARSLLLQRSPERAE-KDD-ELLKA-----S--AK--FQEQTWAL
ESLEELESV-----ESFQESQIIAVPSDS--------------ELEDVKTPGRVEEMTVD
RGGNLKEKENVEI------STPSQ-HWKGTVFRQENVSPFHNQRDFS-AALPYGEL-SGI
QPVHSPSFPRSCCHVSD-TKGVSSFE---NILEPTMLKTNRNS-LATGVGD-QDHSGETG
SSSLQG-SVS-----------------------------------GDASTTHTPWGGSVM
PM-------LMRANGQSVTSDS--IQLETEDWITVSTSSQEDQEGDFRVTSTGLTTQEGL
GSEAEATEQEETK-TSSLDTVLRQTERRVSFLLQEDSDQGEE-ERQK---AEEKSEDQ--
--QL----------------PNSACLPPVSVL----------------------------
-KGPDPEPLLLPDSSVHASICL-----SILEE----------IRQAKAQRKQLNDFVAEG
TVLPYE-TSQEAECFSEAAGRSQTQTVT-----------L-GWDSTRNDAKTQGLHVASP
PPVF--ANLLADERR--AQA------------SAGSLQHVLNPETDRG------------
-PQHHLLASSHIIS--GLAERYCTGEA-RQFCGARGW----SDFSEVIE-KKETSRTMSS
VGPLDSDRLLSILAVEQ--NERVGSE------------------------------K---
----------------------------------VSVLPSQTSCDGPGRILH-----GQS
QL-AAWETAEDISFGGKDTVLGHQKP--S-LDSTCG-----------GDSGKISVTTQK-
GK----------AVHSERQSVIRTVDNTVYLSQPKQDHVQCSDASAGLEGME-ASPKSCA
LQPGAPRKVEA-----EANIWHPVKWKN-VDSGLAEA-CG--------------------
SDSKNLR--ST------------------------PFIDKRPSLHPSGVREE-APGLCPE
E---CLVFKGNTGGSRPLGLSYGE-EEN---CPHLSGSQPAAAVHDCRSHSSTLPCYRDG
VLRKGTLWAAPHPDHSLFIVPSRVCEVDGAGESFSKDSQVSLAHGL----KHK-----CG
PVDNSIPNPSTIALVSSPAQNCSCLCT-SEMKA-NCLTHTVARGRS-VDGSGEKT-T---
---GKKASTAPEDSYPSSPAGMSSEPRRTLKNNSVS-ENVQASQ-TTPEHP--AVTQRPY
SN---EESVDSKLEIA-AQFGHLENT-IRCCSKKMPPSTKVRGHSC-LDSQAKFVDMLKH
TCHP--QIE-TSWEEEEQQRDQVS-GDGKVHAQVRN-----LVSSNI-GSFDGCQTRDGE
RK-----------------EIVVAKSSASQTFFSDFE-------AQTEPSQPAAQTPS-Q
LCSDREQLPP-SHRHLLPVIAIFSGPKRA-RYSPRPQFTVVSSSRSLQELNLS-VKPPSP
TDEDA-QGPNCLWSPHLRGHSSQKPVS-------TSQKSQDYSQKASCNLS----NSHTD
HRPLNPVIPPY---PTSSTVSC-------MPTP---EFMTTWMPGTLE--QAHP-GKTDK
LSVQGMPENWHSQ-VDKEMLHFDSSNLSPYVLPWCPQGPVHIGWKQYVFGSAVDASGSQK
SQCLIQSKMAQCSS--MDNVLEDKKSPFHFHPKTDAQTQDLPNIHSGIGNDQSSN-----
-----------------------------------------------ELPL--AGGSTTA
QVDEIILLCPPETGCAGGE-ASMNTFEQGTRTLG-SR-------LHSNCTDVSV-QPDAR
TMSDS-DLASWTRMHNLSLHLSQLLHSTSELLGSLSQPSVIVKEQNGN--SESLDEAQQ-
-ALMMDGSTQTTVDEGIQTDLALP----------PLAFQ-APEVKSEEVSV-ILHVMDS-
---GITTVA----------QEKGDVPVVFQKKEA-EEAA-----E-----PPDLH-----
-KGSTHVKLQSPPVT-SPHLRFQKADFG--QNFTFMNPPASPDG-SPLPSLQPEESCMVV
NMSR------ISHHSRLTLGA-SEFTQEP--STQNRL-GSSSAVLVDRASSPILTFSASI
QELSN-PLACLTLSVPSA----HPLEDFQKLD-IN---PDPEV-G--DLRPPMGNSQ-AT
DKAGVS---RRAESVDREVKSPL----GKS-----SERLFLYSSSPCSPQQ---------
-----------SSSPQVSFSGKAPQQLQLKSTTGDQS-------------------KSPS
SPPRH------RILDDSVVSERVAS-TEHGPPSSGRP---SQCQGRAANEDGKSVFMVES
Q-PNVDRPS-SRRG--L--------QPLSP--CQISA--------------TTGL-QSPA
VDPPQVCQPVGLLCP---GSQMYVASGPQHHNLRDLSVHNKFNNWYGVQDGPCKSLHVGD
-SLGVRCDLSS-VG--TQRPLQP---------SDKYSQEPEYLRL------EHIPLQAGV
QKPSLSVELTEAKLHHGFGETDALLKVLQSGTGEVFAPEEPAMLSCE--EFYTRQ-----
----------KKTFETLRRERTERLHNFRRTRSLSPQKRLRFLPSKDLPTGELDLPSRRQ
EYLQRLRKHVVETTRIPEPAPR-LARPPSDIELMLQEYRQAREEAKAEIAQARDRLKERS
EQEKKRIRQQIIS--QLL-----KEEEKLQILANSSSLYTS-SNGSISSGVTSDYNSSPA
-FLGHLQSLEVLE-D------------------SQVPDS--QDTWIGDWRGRSTVRNSYL
YLTGSSWKNLAH-----SCRASMGS--GCCS--------PSSLSSLGTCF---SF-PYQD
LAKHIVNTSMADVMAACSDNLHNLFIRQASAGWNYQGEEQEV---------

PF01852 // ENSGT00890000139327_7_Domain_2 (5632, 5806)

QLYYKEFS-
-STRHGFLG--AGVVSQPLSQVWAAVSDPTLWPLYHKPIQTSRLHQRVTNSISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GHLSIMATQSVYDASMPRPSRKMVRGEILPSAW
VLQPVLLEGKEITRVIFLVQVELGAPGFPPHLLNSFIKQQPLVVAKLASFLRR

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--------------------------------EEPQLAPGSRDHGG-LNPQEKFITELKY
ISRS--QVD-SLWEEEEQQRDQAA-GGREDPAGVRS-----PPCADE-GGSDSCQIRSAD
RE-----------------GRTVARS-VSKTISPSFGDSAAVSLGQRRAHWPAAQGPR-Q
PSSGGEQPVP-HHRSARPIIAVFSGRRYS-----RPQFSVVSSSRSLQELNLS-VEPPSP
TEEDI-VEPNRLWTSHPRGTSSEKSAV------RTSLNAEGCDQEASSDLD----SIAAD
LRPLPPAPPPY---SATSGFSR-------MPTP---NLTSVHPSGALE--QAQS-GKPER
LGGQARPEEWHSTDVDRGALLLGPSDVNPCILPWHPKGPARAGWRRHVFGGAVSVSRRPT
SQGLTPPNVAQ-SS--MDSHVEDQSSLFRSHLSTLASAQSLLNKRSSVGNARGS------
----------------------------------------------REPPW--AEESTAG
PVDEIMLLYPSEVGGPIAQ-SRMDTLEQGTQTLG-CG-------SHWSYSDFSSAQS---
------DLASWASMHNLSLHLSQLLHSTSELLGSLSQPSVAEKEWNAK--RDTPHEVPQ-
-TQMTDGSTQTTVDEGIQTDLASP----------PLHLQ-APEADPQKVNV-ILEGLGS-
---DLTSMC----------QGEGRVPRALQKRKA-EETVWK-TAG-----PLDLQ-----
-GEDNLCRPQSAPVPS-FHFNLQKGPFG--QNLPSLSPQASPDALLPPSSQAEEPSCLAV
GRPCL----SAFSSPGPCPHP-VESVGEL--RVQ-EQ-GSASTLLVDRASSPILTLSAST
PGSGIP-PSALSLSSPSA----LSLDSLQKLV-SS---PSLPL---PAPRPPVGNFSQTT
DEADGS---QRARAPCGEGRSSL----EGG-----NHRPFFGVSSQGNPQQ---------
-----------STKLQVRFVQQPLQQCLPRTTAGVQS-------------------RLSP
PPLGNR----SQRLADSFLPEDMAS-LECGPLSRRGP---GGWQSRVEKRGERSASPAEL
Q-PSLDGPC-PRGV--L--------QRHSP--CPFSELTD-----------TPGL-QGCV
LGPPVACQPGGLLPP---SSQMHMAPEPQHHGLRDLPVHNKFSDWCGPQNSSPGGPGTVD
-SLGTRCDCSS-GEQ-SQRLPQA---------PQEQIRAPEWPQR------EQIPLKVGA
QNLSLSTELTEAKLHHGFGEADALLQVLQSGTGEALAAEEEELNARDSVTFCLRP-----
----------KHTAETLQRKRAEGLQNSRWTRSLSPEKQLSFA-------RDFDLPSRRR
EYLQQLRKDVVETTRSSVSTSR-SSHPPSDIELMLQEYQRAREEAKVEIARARDRLRERT
EQEKLRIRQQIISQLLR-------EKEKLHTLATSGSRCTS-SDGSLSSGVTSGYNSSPA
-LPSQLQSPDSVG-D------------------TNLPDS--RDSWIGEVRGRSSVRNNQL
NLAGSAWKSLAY-----SRRAALGS--CCCS--------PSSLSSLGTSF---SS-SYKD
LAKHIVDLSMADVMAACSDNLNNLFSCWAA

PF01852 // ENSGT00890000139327_7_Domain_2 (5611, 5806)

AGWNHQGEEQEV---------QLYYKMFS-
-STRHGFLG--AGVVSQPLSHVWAAVSDPTLWPLYHKPVQTARLHQRVTNSINLVYLVCN
TTVCALKQPRDFCCVCVEAKE------GQLSIMAAQSVYDASMPRPNREMVRGEILPSAW
ILQPLTVEGKEITRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVMAFG
FDYCYWSVNPQDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5653)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPPRDGETSHRAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQSWISQQIKENQQCLLREETWLASLQQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPRPQ-CRSKLTSCSSLSP--
QRLC---SKHVPQLHS-------------IFLSWDPSTILPPMPDPTH----QTSEKTSS
EECLSQAASYPPRIGCLRKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPSS----
-VGIQEMERVGKQPHQVVIQGLASLRKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASCNS---------PYPHGPRQTAGHGKAVK
TFW--TEYKPPSLSRASKRHQR--VLAARVRNITKKSSHLPLRSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DSDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRARASVRGFAA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPFPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSRPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGEGGDTSLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLGGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPGSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNTCHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SQ-YSLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNRQALQDAYLKNNLPVLLQNQNSKVASSQ-QVTA---EIPVDLNTGEVI
RESGKCPGNIT-E-----ESR----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPGMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
KGPGK-SQE----MLNS--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPVREHTH--
PAGSDRLARDIF--ES--------------LGKHTTCRE-----FTNTSFRPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KSFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RGRSLQEENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRWPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVHH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGTEDKISASTSP-QDHGKDLRITLLDFSTSEDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEKETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSLEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECPSGVAGGPQCKQIE-----------LSSSDQTRNEGEAPGFHVASL
SAEAGQTDLSADERK--VQA--------TPL-SADSFQSLPNTETDRQ------------
-PWDPMQAFSHAAP--ALDKKHCAGEL-RQFAGTSEPFICHSDSSEILEKKKDATRTPSS
VDPLAPDSLLSSAPVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RALNTTYG-----------EVSGNSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPEQDHVQCPEASTGFEEGR-ANLKQDT
VLPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALHGPVFSRNPEGSRTLSASRGK-ESRTLPCRQPCSSQPV-ATRSYSCHSSTLLCCRGG
DLGKEPFKAALRTVYPPCGVPSRAYEMDETGETSSRGCDVLLTHGL----EPKDVNREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--TELEATSFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVESKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHDC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDTR
RQ-----------------EVAVAKPPVSKILSQGFKNPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPVTAIFSGPERS-KSSPTPQISVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKSMA------RTSLQAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVSSTLSH-------MPTP---DFMTSWMSGTLE--QGQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSDISPYALLWRPEEHARIGWKQYVFGSTVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPLHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSVSLGDPHILTSSEGVAPTLG-HDRRPQFRGPSGEAD-CLRSKPPL--AEGSAAG
PADEIMLPYPSGAGCPVGQ-IRMNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAT
AASAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASP----------TLRLQ-ASEAEPQGANV-ILEGLGS-
---HTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEESSCIAV
SSPSP----SPCHSPGLLPST-SEYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GGVL----QRS-----NGRSFLELHSPHNPRQ---------
-----------SPKLQFSFLGQHPQQLQPSTTIGVQS-------------------RLLP
PPLRHR----SQTLADSFVPEEVAS-PERGPLSGREP---SQWRSRTENGGESSASPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQK----GMDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKELFVWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVSQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQAPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

------------------------------------------------------------
--------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (81, 421)

VFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMIGTPA
SLGLTP-RICE-----------------------------GLFSKKDDYSNLPPPCRIRV
SFLEIYNERVRDLLKQSDQKKPYTLRVREHPQTGPYVQGLSQHVVTNSKQIIGLLEEGVA
N--RITAATHVHEASSRSHAIFTIYYTQAILENNLSSEIASKINLVDLAGSERADPSYCK
DRITEGASINKSLVTLGIVISTLEAQNSQMFINYQSPNSTS-SEGGDSGSLSSPSVAGSI
GGIPRKQSYIPYRDSVLTWLLKDSLGGNSKTIMVAN-----SSYSETMSTLRYASSA-KS
IINKPRVNEGN--------------------------L-SPFMDGRNGNLKELVLHNEMK
RDQLSKDWTQKWDDWKVLME-CNVDINKKKAGVMIDSNLPHLMVLDDDVLSTGVVLYHL-
-------------------RGQWIERNHCTITSVCGVVTLQPALGARCTVNGQEVTDSCR
LTQGAIIILGETQKFRFIHPAEAAALRQR-RLLGEVSAGNSNCSLEWLDLDGDVTAPQLG
ISSVLED-SNRRVRDVSEAYHQKHLDQAVSHRTQIR--QQKRLVKDLRQDILVGQIRAEQ
ELEFDQALINQQIKDNQRWLLREESRLASLQQQQQQQQQEEEQQQQQQEDGTSAEEDTEI
FHEAESQIGPETPSASLDGGR-TRLVQLQVLWRNALWAAERKVRRKKVK--FQLEKIIKK
QKLLEAQKKLEQLETLSWKDNPSRLNPD-----LDA--NFSAFQKKSDSSTSSSSLVD--
ASLL---SSHQ-----------RKLYTSLIFLEAGSDTSLAPQLS--AETVHHLPEKPQS
GDYLFQAASV-PRGSITPPDAS-GPPSLWQPCEGQAEPGNGQEEAAAGAATPTPG-----
DRRSQEMGR-RKQPLGRLHRPLASVSRSAEQLRSRDR-PDSFFLSPRSVREKPSGSH---
-SLPRRRWRRER-DLLTNRCS------------P--HSQGARRSVVYGKIQATRLCQAAW
ALQRWEPGAASLARGSTWP------------------RGRLFGNPMRREGEEGTWSAGIL
RAIPGSLGARAQENDDDFSDTDSTYSLDSLSYTYTRT-LIKPQEQEAPEPKA-RCTELEN
SESDDSQMSQDSLVEKRNRTPRRLLPVSPLLQGPE----RSEVRSMASSKASL-PSSGSE
LPWEKMSTFSLDSLNNEEE--DFREESKEGPASHSSDEMPAELFWQVKSSRSLPECQ--E
QELEFQASDQGPGSAGPDATLKPSTSFYLTLQPET-------------------------
----------------TQNPRNS---SLVSMDSWFSCDSDSKPNDPQEVSLYSQMNLGIQ
QLQVRDMEKPVVLVGVGGVQQPAPELATEVYSFSPLLGSGLVPRTAHEG-----------
----------SGKP-SLEVPSEAPWRSPGPC---KPGSDAAGSLQALPEEGRDLASLTGY
CSPVPSNSTL-PCSLSAAPAALL--SHKGSILGKGR------PV--VEYLCEFSHSSLGA
TVRSTQ-----VSSSSQKDT--SYLPFTSGKKWDSFFPVCPKMPGDFDFNDASSSLPSTR
QLRTEQERNGGSLELDDLSTLFRTIEKDAHHSCP-S----ADLEAGD-PGLEN--AWVFA
AENKVSASGA-----QAHPAHQGIPKQ-SSPVACRRAGSAVPFDESFFLRDISNSNSP-M
NAKEEQSPPAWAQREENLPSRLVPLKLN--NP-LSQPAMKTELLQNTS-EQIDRERSFS-
--LALTTDSE-----PSWDFFPSP-ERLHPVETFYMLESRDALTETALEIPACREWGEDM
PSASRAEELNNTFQFFRTV--DSDLLLLLHTPKAKNPSSQ-QVAG---ERSFSPGNKKDL
TG----TGVPQ-S-----MEKFS--------------------NPFAFSAAQNRLLLESI
SMAACHLGKPGGILNNKHPQSTLKIK---EE-DP-D------QPPWGVPFSDSGA-----
-------------VI-----SSIEGDHKHRESEK--------------------------
-------TDSSNQAQHRV--NMQENALISKKRSSSNHSECTSPAIMSKDETSPHPK----
-EGTESVSLGMALHPKDCSEESVTQRRDP-------PYGKDSASNPTLST--------KE
EGTIA-NKEPEN----------------LMGKIVNHSEEMARLISSVSQ--LESSIMEID
SRQKYHPCALYMAEAYRRAMCRDR-KDHGKAHLTLR---PNDFREILYHRDQPHSPKKVQ
EEEVP-NSIEAREIK-KVNNCIQ-----TQKITP----NLTRPTEVTEEGKTEREHTPL-
-SVPELSVRCPS--DY--------------LFLRFSQRCTAQKKSASAPESPEG------
------------VEPLVRTEPTRAKEERSEGSRN-EESAS-----E--LNP-QSHATLGT
GSFPKLEPK-----PTFQENQTAGNLTSTVMTA----------KCKEVRVHDIDQETNIL
RGKSMQAGTY-PAPLTQGLSGVSQILHTGRYRTQETAHPRPSQEGYPAVSTKE----GNI
FFSDPPKLSEKYFRSTMKAVSLSSAA---SEPDLEFLKTQAPT-PSEGREEQQKINGEAR
NHSSLR-SISCKNS----------------------------------FVEQSVWQSFSL
RTVSGLCYQPNGAGSSPGEASNDSYSMEEMKASATAVLL-EQQREDTRITPRDLNLGNSS
LTEAELTLLRNIKRASSLI--QSPLEKRTSHQWADRELQIPQAV-EK---KLWRTEDFA-
----------------------RFWGTSATPSMYP-------------------------
-KMKVETP-----ASTTPSVYPKMNVEITVEN-----------KLSQECRKCSKDSSDKQ
IIMSHSESLLELEALSGSPKQPHYNQRD-----------QLELARTHREDESQVYFVQNQ
AARRHLQ--EASPGT-------------ASV--------LASGNMLSP------------
----------------SALEDNCEESV---------------------------RLAPSF
H-------------------------------------------GISNNIRLIQQELSQA
LLCKQIEAHSEVERTSLGSKESIQRLWEEFRSQNT-AYGNLSGGDSSEAVVDPQTHLVAS
-MQSPWK-----------DAPLQAGSAMSAVEMSYAVVDSTTPGPVFASQGSFHIRKQPI
ISCEAETIETEDPSYLDSPLAASDIKQSRSLPAHP----RCV-PSPGLGERR-ASHKQEP
AGSGTVEGGST-----GGALPQYPKLKGVALSGQSLA-YG--------------------
VGNRCPR--PA------------------------PLLDQRLV----GEMEE-SSEGSLV
QSK-----AEVSKSTIMFRPLASQREAVTSPSRPPCMSLQG-DAFIDSPSFTNSLSHGNN
DPEKRISRSSSDTMLPVFLTSSKLTVG-----HQSRGPNIPLAHSL----DLRERQQELR
L--------------------------------------AASNTSLCGIESPGSEDI---
---KKKAA--FKPETTSLSSQTYSEKLENLQEEHEASQNEWEFLPGAEEPGNHVKIGRLE
AMHVSEDIFENEPTMG-F----------PHLAQGPSFPKDSRDHST-PIPYPRTKMGKKC
IFSN--VSG-NLWKTDENEQLSNN-VG--NTMWDRN-----HHHLGTSGRVSPQGPRGSP
RTDGKVSTPE----------------RLLKTNNGPFDDEEPCLLSEGS------------
--QDDLDTGS-HDRDLAPCVAFSCSPGHSPKDFSPLKASVGTSSKFPQELNMS-VEPPSP
TEDEESRGTERLYL---NDLSPDESE-MMLVELGRCPRPADRGQTAPPDYG----LEASG
LRSPAPGSPPY---PTSSTLLT-------MPVP---EGR---LADVLE----------EE
QHDPLRNKGWLTL-ENMDVTQGTSAKINPFVQSWHQEGPGRIGWKQYVLGSASDTSCNQI
SWSLDTQRAVRCSS--VDNGLDTSSSPYHSQLSSSANPHELSSPS-SIEDPRGLEEERKS
FK--TSSVVRSHHGFSDTSLTVPSSGIPDKVG--EGLPE------DECTLF--EQREVSG
KMGDLALLYPTESSPK----ADTATCEQGTMTLT-STQLQQVHMHCQVCVDAPH------
---P-SHPATWKSMHNLSMHLSQLLHNTSELLGNLSHQGTPERERGIK--AEAPEEPPK-
-AMTMDSSTQTTVDVGIQTDEMDPAPQDV-----SLHSSGDQLASPQEANV-TTLKHSSL
DGMDAL-DTPQELEHSLVLQEKVDHPLVLQEENK-GTVETKETSS-----SSGSQ-----
--KESSFS-PDSLDTSHRNLSFQEHSFS--QEV--VRLQASSATSPSSSSHKLGSSCTAV
PNTTSCTASSL---RDSSSQE-GESTCESSTQNNKKA-GYKNTLLVDRASSPILTFSASA
QGPHSSSSSTSSSSSSSSSSSNPPCLGSSHFH-STILHQKLR----ASRVSSAHSFSQAN
NEDSGK----------SMGKKLN----KGFLASNPTGT----------LKP---------
----SSLWLHGSSSSTSTGLLSSPQQLQVRASLGLLGWEEQLAGEKKKKHSWERPLYLSL
PTTGLS-------------PTEV-------QLASP---STSWCQKRTGTGADTSEQLLKS
P-LPSE-TP-FLGR--------VVNHCHGP--SSISEISVA---------------PG-H
GSIARDTQSEVLLTS---CTQKVQTADPKKYNLKDLPVHNKFSNWCGVQGSSPQGTVPAE
-AAVNAANSSSEGLQE--KSAQL---------SKHLSQMPEQLQREQVQVLAGVPLELGP
QTPPLSVELAEAKLLYGLGETDALLRVMQSGTGEALAPDAPRSSQKE--EMYFRR-----
----------LKTIEVMRRERSDRLQNFRRARSLSPMKQLGLLPTPEVFPRDADLPSRRR
EYLQQLRKDVVETTRNLESASDTASHQPSDIEVLLRDYQRAREETKMEIARARDRLRERA
EQEKQRIRQQIVSQLQR-------EEAKLQTLVSVSTLCTTSSMDSRSSSPTSGYDSSNL
TLASQSQPPEKQG-N------------------ANIPCF--KETTGGDLRGRSALRGKS-
------------------HRASFDR--PHKS--------LLSQSNSDSCLSTSPGILYHD
LVKHILTSTMAEVMAACSDNLQNLFSCQATAGWKYQGEEKDV---------LTYYKGFPS
-ATRHGFLG--AGVVPQPLPRVWAAVRDPTTWTLYDKSIQTAQLYQKVTNTIKLVYLVSS
TSINCLKQPRDFCCVSAEAKE------GHLTIMVAQSVYDKSMPRPSGNMIRGEILPSAW
LLQPHTVDGKEVTKVIHMVQVELGAPGLPPGLLTHCAKQQPLVIANLASFLCG

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDDKVAKIRNVKVDSRPESFGDTREKVVAFG
FDYCYWSVNPEDPHYASQEVVFRDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIREDDCASQPCSRSIKV
SFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHVVTNYQQVIQLLEAGIA
N--RITAATHVHEASSRSHAIFTIHCTQAILQNNLPSETASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLSSAA-SSGGDSGVPSTTSGASSG
GGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKAVLLNFEL-------------------------
IDTLTQHWTEKRNDRQALMEHYGVDINRKRARVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSTCGVVILRPTQGARCTVNGREVTASCR
LTQGAVITLGKAQKFRFNHPAEAAVLRHQRLKVGEALGSS--GSLEWLDLDGDVSASRLG
LCPVLRK-ERRVLEEQCDRDQQPSRHSEIPYRAQPE--QQQCHVEALKQQAKEGQSRVQK
ELELDHTHISQQIKDNQQWLLTEETWLASLRETQ-QE--GNCGEEK--------ELEASV
APDAWLPTVPQTPPSPLVQSQ-KRVVQPQCSPRHTTRATVWNIRQKKVS--FQLERIIKK
RRLLEAQRRLEQLSTFFWIQDDGASRAPSWASSSNT--SGPGSQ-RRSRWTTCSSLSL--
QRLG---CRRLPQLHS-------------DFMNWDPSAMSPPVPELTH----QMPEKTLS
TDCI------PPKAGRLGRNSF-HSSRWRKFSPARRA------STQGTHLTVSHKS----
-VSSQEIESLGKQPCQMSSQGQ-----STKKQKARDG-SRTFIPAAQTRW-----AS---
-VNTKTGWQKEG-TCGTYKDP------KETTSQS---------TDLSGLEPAAGHRKVVK
TFQ--AESKPSPSSRASKKHQR--VLAARARDIVKTFSRLPHGGPLKNQPRAGDPGTPAS
FTDSRPIKDPVREEDRDLSDTESSYSVDSLSYIYAKV-PKKLLKPEDLQ-GKWNLPDSEN
SESDNSQISEDSLAGKGHKSLPENSRGEYSMKDHG----HSRARTSASVRGLPM-PSDSS
LCTQKYRSFSLDSLIDPEN-------RQGEPFLGSADEMPTETFWHLQNATPSSVDQ--E
AMDRPSPTNHRMG-VGVNVLLPKSNSFYLDPQFQP------------------PCEQLES
EMEASYSEHTNPLRG-LQLARES---PLLSVDSWFSCDSKVSPSSPSGDIHSLCPSPDIH
EIQPHD-EKPKHWLSIEEPKP--------PGTCKLPQSSTEPPCSS-DL------Y----
-----------ATS-ASDTSKPSVCESQGLL---QPG-----DGGFF--QGREMPDMTNQ
GISEESHNSDMSSVLAPSATSF---TQVCSVN-KDW------AALHQEYLLELSDSGFEA
VGEPRP-----AFPFLEEDS--SSLAEASDK-VDTQLPTGPGLPRNLDFSSFPVHISKIG
HLRAEKDHDSLSAKVESASDLLSTVER-MSSNGTYP----ADIESLT-SGSIN--AQPYT
AGNVIPSSMT-----EAWEVHRASLEG-CLQGD-RHSVLITSSG----QKRAYHNDDT-L
ATEGDCLPQDGALLGKNTKVQPGLLSHN--SYQQPLLEEKAASQQCTDGEVAGTRIDAC-
--CAFPSGPELFLHSTPWSSSPSS-LQPPPLETFYVTKSRDALTETALEIPACREAWVPS
PPPREAWGFDHSHQVSQKAHWKNNLPKLSQSQNSKIDSPQ-QTTT---KRPTDLDTGEGT
EELGKHSRNMREE-----ENH----------------------DSAYSFVAQNRQHLPST
RLKVCECGNQLGILNKEYSLSVHQDE---EG-AS-A------WHHGSVAFNGSE------
-------------PKTLLFICDSKASGEEQSL----------LLPQIQSCGMHSQS-PGA
RSDFIGKIANLDPEKVIP--EEAA----VSLKSRSLHCL-SSPVIVAGGRSPTRRR----
EGRNETGLLRE-VISKDIQEEFSLPGTQY-------ICER--CHLLLCSR-ERKP--TEC
KAHGQ-SQE----V-QS--KEEPLEEKQNKRVN--NIDEMARLMRSVMQ--LETGILEIE
SKHNKHLHASHMPST--ELMLQDL-EDQEKADHVPT---PESSGEHLCFEDQPSFPIQIK
DDIFE--DSKAREI--EVTNATSNNNTQIQKLTG----SPFRSREYVQTRESESEHSYP-
PPGADRLARDTC--DS--------------LGKGTALRK-----PSNISLHSRT------
------------MRGLARALPLQPSIERPK-KDN-ELLKA-----S--AK--FQGQTWAL
ESLEELESM-----ERFQESQIVVVPSGS--------------ELEDAKTQGGVEEMTVD
RRGSLQEKED-MVSSTQKVPTPSQ-HWKGTFFSQEAVSPFYYQTGFS-AALPHGEL-SGT
QPVHSLSFPRSGLHGSD-TKGVSSFE---YILEPVMLKTNRNS-LATGVGD-QDHSGETR
SSSPQE-RAS-----------------------------------GDVSTTHTPLGGSVM
PV-------VVRASGQAVTSDS--TLLNTEDWITVSTSSQEDQEGDFRDTSTGSTTQEAL
GSEAEATVQKERK-NSSLDRISRQAEKRVSFLLQEDSNQGEE-ERQK---AEETSEDQ--
--QL----------------PNSAYLTPISEL----------------------------
-KGPDAEPLLLPDSSINASICL-----GILAE----------IRQAKTQRKQLTDLVAEG
TVLPYE-TLQEAEWFSEAAGKPQTQKVK-----------L-GWGSTRNDAKAQRLHEASP
SAVS--ADLLADERK--AQV------------SAGSFHHLPNPETDRG------------
-PQHHLLASPHIVS--ELEKRYCTGKP-RQFCGASGR----SDSSEVIEKRKEASRTKSS
VDPLPSDRLLSIPAVEQ--DGGLGSE------------------------------K---
----------------------------------VSVLPSQTS-YAPGRILH-----GQG
QL-TARETVKGLSFGGKDSILGHQEP--RSLDSTHG-----------GGSEKISVTTQK-
EN----------AVFSECPSVICTVDNAVDLSQSKQDHVQGLDASTGLEETK-ASPKSGA
VHPEAPGNVGA-----EANIRHPVKWKN-VDSGL--A-CG--------------------
GDSKNPW--ST------------------------PFLDQRPSLHPSGVREE-APGPCPK
E---CLVFERNTGGSRPLGSSYEEAENRTIPCPHLSGSQPTTAVHACCSHSSTLLCCRDG
VLRKGTPWAAAPPDHSLCIVPSTVCEVDGTGECLSR---VSLAHDL----KHK-----CG
PVDNSIPNPPTTTPVSSPAQNCSCLST-SEMR-ARCLTHTFARGRS-VEGSGEE-TT---
---GKKVTTAPEDTFPSSPAGMSSEPLRTLKNNSVD-ENGQASQ-TMPEPP--AVTQGPG
TLNSN-ECVDSKLVIA-AQFGHLENT--KCCSEKMQPSTKVRGHSC-LAPQARFVDMLKP
TCHP--KIE-TSWEEEEQQRDQVS-GDGKDHAQVRN-----LVPSNV-GGFDGYQTRDGE
T-----------------------KSSVPQTFFSDFE-------AQTEPSQPAAQTHS-Q
HCSDREQLPRS-HRHLLPVIAIFSGPKHA-RYSPRPQFTVVSSSRSLQELNLS-VEPPSP
TDEDA-QRPDSSWRPHLRGYSSEKPIS-------TSLKTQDCSQKALCNLN----NSSSN
HRPLNPVIPPY---PTSSTVSC-------MPTP---EFMTTWMPGALE--QAHQ-GKTDK
LSVQGMPENWHSQ-TDEEMLHFGSSELSPSVLSSCPQGLVHIGWKQYVFGSAVDVSCSQK
PQCLIQSNMAQCSS--IDNVLEDKKSPFHSHPKTDAQTQDLPNIHSDVENDQSSN-----
-----------------------------------------------ELPL--VGGSATA
QVDEILLLCPPEMGCAGGE-ASVNTFEQGTQALG-SR-------RHWCCTDVSL-QPEAR
TMSDS-ELASWTSMHNLSVHLSQLLHSTSELLGSLSHPGVVIKEQNVK--RDSLDEAQQ-
-ALRMDGSASTTVDEGIQTDLALP----------PLAFQ-GPEVKSEEVSV-ILDMMDS-
---GITTVA----------QEKGDVPVVFQKREA-EGAA-----E-----TPGLH-----
-EESTHNKLQSPPLP-SPHLRVQKADLG--QNFTFMSPPASPDG-SPPPSLRPEESCMVV
NMPR------FSPHSGLSLGA-FESTQEP--RTQKRL-CGSRAVLVDRASSPILTFSASI
QELSN-PLACVTLSAPSV----HPLEDFQKLDDIN---SDLAV-G--DPRPPVDNS-QAT
DESGDS---QRAESLDREGKSPL----GKS-----SERLLLDNSSSCSPQQ---------
-----------SSSLQVSFLGIAPQQLQPKTTTGDQS-------------------KLPS
PPPRHK----NPKLDDSCVSEKVTS-VEHGPL---RP---SQWQGRTTNKDWGSEFMVEP
Q-PNLDQPS-SRRG--L--------QPLSP--CQISD--------------TTGL-QSPA
VDPPQACHPVGLLCS---GSHMHVAPGPQHYNLRDLPVHNNFNNLYGVQGGPGRGLHEGE
-SLGVRCDSSS-VG--THRPPQL---------SDKYSQNLEWLRL------EHIPLQAGV
QKLALSVELTEAKLHHGFGETDALLKVLQSGTGEVLAPQEPAVPSSE--EFYTRQ-----
----------KKTIETLRRQRAERLHNFRRTRSLSPQKQLGLLPSKDLPTWELDLPSRRQ
EYLQQLRKHIVDTTRIPEPAPG-LARPPSDIELMLQEYRRAREEAKVEIAQARDRLKERT
EQEKMRIRQQIIS--QLL-----KEEEKLQTLANFSSLYTS-SNGSISSGVTSGYNSSPA
-FSGHLQSLEVSG-D------------------SQVPDS--QDTWIGDWQDQSTVRNSYL
YLTGSSWKSLAH-----SRRASMGS--GCCS--------ASSLSSLGACF---SF-PYQD
LAKHIVSTSMADVMAACSDNLHNLFIRQATDGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--ASVVSQPLSQVWAAVSDPTLWPLYHKPIQTARLHQRVTNSISLVYLVCN
TTLCELKQLRDFCCVCVEAKE------GCLSIMAAQSVYDASMPRPSRKMVRGEILPSAW
VLQPVIIEGKEITRVISLVQVELGAPGFPPHLLNSCIKQQPLVVAKLASFLRS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRKLKVNSRPDGFGDSQEKVVAFG
FDYCYWSVNPEDPQYASQDVVFRDLGAEVLSGATKGYNICLFAYGQTGSGKTYTMLGTPA
SLGLTP-RICE-----------------------------GLFIREEDYASLPSSCRIKV
SFLEIYNERVRDLLKQSDQRKSYTLRIREHPEMGPYVQGLSQHLVTSYKQVIQLLEEGIA
N--RITAATHVHETSSRSHAIFTIHYTQAILENNLPSEIASKINLVDLAGSERADPNYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSRCQSLSYAA-SS----------SGTSGG
GRPPRRQSYIPYRDSVLTWLLKDSLGGNSRTIMVATVSPAHTSYNETMSTLRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANIKLIRELREEIERLKAMLLSFELRNF-HWLHSENDGNLKELVSQSEVK
IDQLTKDWAEKWNDWQALMEHYSVDINRRRAGVVIDSNLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPVQGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKALKFRFNHPAEAAVLRQR-RQVGEPVGGS--DSLEWLDLDGDATASRPG
LCPLLWK-QRTALEEQCSEDHQLLKCGATSHRAQTQ--QQRCHVENLRQQILAGQRRAEK
ALELGQAHFSQQIKGGQQWLLR-ETWLSGLQQQ------QQQQQQE--------DRGS-E
KEREASVADLETQSSPRLRSQ-K-----QLPRKHTLRATKWNIRRRKIP--LQLERVIKK
QRLLEAQRRPEQLRALCRLQDDSTQEPSCQIPRSDA--TVPGPQ-RRNKPASCSVLSL--
RKLC---SQRLP-------------QLPSVFSKWDLSTMLPPMPDPTH----QALVKAPS
EAQFPKAASYLPRTARLHKNRI-RFSGQQQFFATRGALARKVALTPGTRITVSPKS----
-V---EMERVG-KPCEIVAQGLASLSQSVNKLKSKNE-PKTHTP-TMTRKMKELANP---
-EHTKAEWQKEE-NLGTHKPA------KGGS------------LCPHGPKQAAGRGKAAK
PYR--AESKPPFPSRASKRHQK--ILVARVKDIARTSSHLLHGRLSKRRHGAADPDTAAP
LTDSSPAVHNARGKDKGFSDTDSSYSADSLSCVCAKA-LTAPLKAEGPQGNKWNLPGTEN
SESDDSQISEDSLAEKGLTDSKDSPRSNQPTNDHG----HPRTRIKATGRDFSMVSSDSG
LLAQSQRSFSLDSLIDAEE--EVGEEGQKEPLLAPANEMPTETFWRLQNSSLPVLEQ--E
ATCRLGPINHQTG-ARLATILPVSSSFRLDPQFQP------------------HCEQPES
EVEASYSERANSLQG-IQVSRES---PLVSMDSWFSCDSKISPNSPHGIVGSLCPSPDAQ
EVQPCGGEGPGYWLNIEELKSSGTGTVF-PCSSKLSEGSTDQPCNVRNV------Y----
-----------TTS-TSDTSKLSLWGGQKLL---QTR-----AEGVF--QDSGIPDATQQ
GSSGASQNSSVSSVLAASAASF---TYVGSTSERDW------AALQQKYLLELSHPIFEA
IGEPRA-----ALPCLGGDS--GSLAEACGTGGDTVLVTGSGVSSDLNCSSFPNHPSKIR
HLRAEKEQDSLNTRLESTSDFFSTSEKEVSYNETYS----ADLESLA-SGPTK--AQVFA
AENKIPNSTT-----EAYEVKQNHLQE-CFQGS-RKSGLMASSHGYFFQKNVCHNHLT-I
ATKADHWSHSWTPLRTTSAVQSEQFSHG--SH-SSPQAEKAGRQESSQ-EVVARHTDVS-
--FAFSSGPELVLHSAPWNPLPSS-LQPPPLETFYVTKSRDALTETALEIPACREVRAPS
PPPREAWGLGPDRQALQSAYFEDNLPVLLQNQNSKMAAAQ-QGIA---GKPVDLNAREVI
RELGRCPGNIQ-E-----ESSNA--------------------NSVYFFVAEDRHFIPSS
GTGVREYENQVGIFY--------HEG---EE-AA-A------RSCGNVSSGSSGS-----
-------------GKPLLLICESETGE-EEQGQ-------TSVLRQAQAQDRNRQLSSGA
RIDFIYKTTRLELKKGRP--GESD----DSFVSRALHYRGNSPVIAGPDESLPRKW----
EAENETGLLGKTLHPEDSAEEMKLRGTEC-------IYDR--CQSVTCSQ-ERNP--SAY
RGPG---QA----VLNP--KEEPSGKGKKKRIS--NADEMARLVRSVMQ--LEDSILEIG
SKQNKQLHASHTPGVSEESVFQD----QEKADHVLR---TGGPGNPWTFEDQLPTPRQTG
DVIVS--DNEAGEV--DVNSSAGNDSQ-ARK-TV----NPFKSWERVQESKLVREYTHP-
-AELDPPTRDTC--DS--------------SGTCPAHKE-----STNTYFHPRR------
------------MTALAKAVPLEPRPQRSSETVK-SVK-A-----S--VS--PSEQLWGL
G--KELKTV-----ADFKESQISSHMSSS--------------KQEEPKAQDRVEVMAMQ
RGGDLQEETK-MVSLAQKLSGPCR-LCMGTFFSPETVCPLLSQTDFT-SAPTHPGL-SNT
LPLISPRLPRHHLHTPA-TVGASL-----DMLDLTTLEIHDTP-LVPG--H-QDRNGETR
IHSPEG-DGS-----------------------------------GGSSVEISACCRSAV
SM-------AMGSLGQPGAPEN--IPLGTEDKVSASISP-QDQEGNLRVTSMGLNARERL
DSETEAPVQEEL-RTSTLNRVCRLLEKRVHFPLEDDNDQGRK-ARQK---AEKEAEDT--
--EL----------------SSDMFLAPASLP----------------------------
-RVPNSKPRLLE-PSVHASMCL-----AILEE----------IRQAKAQRKPLSDFVPEQ
TALPYREAL--PDSSSGATGGPHWKQTG-----------HLVSGRTGSEDETQGFCVSSP
SAATN--------ER-QGQT--------TPI-AAGRFHPLRNTDSDTR------------
-WRHPSQASSPAAP--AAG----AGEL-KPLLGAGTQCMGSFL-----------------
----------SSAAVED--NEEEAPE-----------------------------KV---
----------------------------------AVALPSQAPCDGSGVILR-----RQS
HL-AAWETAEGMPTGSQDSSPERQEP--RTVDCAYG-----------GLSGS--------
------------------------------------------------------------
------------------------------------------------------------
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-----------TRGSRTLSSSKGQEESR-RLCRQLCDAQPA-ALLACASPSCSSLCYGDG
HPGRRTSKAGLHASHPPCTLHSRACEMDETGQNSYRESEVLLAHGL----EPKSMNMELR
PADSSALEPSTTAATLCPARGDGSPSV-PEVR-TGSFSRTAADGSSRSVRDPEKKGP---
---VE------------LSTARFPEPPRRFQDNSVGSQNTQVSH-SMPAPL--PTAWGPH
PLNVSEDSV-SELVEE-PHNGCLEST-ARCLSEKTQLPIEAGDQSF-LNPQVQFVTRLKL
VCSP--RVE-SPWEEEEQQRDQAL-GGGENP-----------TPPDD-GGSDGCQSRETV
RK-----------------EMAVTESPVSNSFSPNLG-----------------------
-QSETLEPAA-HHRCSLPVIAVFSGHKH-SKSSPRPQFSVVSSSRSLQELNLS-VEPSSS
ADKDT-QEVNRLSNPHLRGCFSEKSVA------GTSLKAEHCDQKSPSSVA----DSPAD
HRPLEPATAPY---PTS-AASC-------MPTP---GSVTSWMSGTLE--QAQQ-GKAEK
LSVQVRPGSWHSE-VNKGMLLSGSSGINPCVLPKCPEGPVCIGWKQYVFGSMTNDSCSQK
SQGLTSSNVAQCSS--VDNGSEDQNSSSHSHLCPCAKTLALLGSQNSTEIAQDSDEACRV
WS--SSFDVGEPHVPTGPAAAPATLD-PDERPQFKDLPDEAG-CLGHDRPL--AEGSAVG
PVDETLLLCEPEAGCAGGQ-AGVNTSEQSTQTVG-CR-------CPWSRADLASAQPGAS
AVSAS-DLSAWTRMHSLSLHLSQLLRSTSELLRSLSQPSVTNRQHDAK--KDTLEKPSQ-
-APMMDGSTQTTLDKGSQTDLALP----------ALCLQ-VQEEKLKKTNM-ILDVLGS-
---EVSTMFP---------EGR-DVSGPLQEE-----GTGE-TSG-----PPDLQ-----
-EGSTHERPQSPPGPS-SHLRFQKAPLG--QDLHSVSTSGPLGASRPPSAQPKGSSCTVV
RSPSL----VISQLPGLFPST-SESTGEP--RVRTR--SPVSALLVDRASSPILTLSAST
QELGLHL-GLLAASAPSA----PPLESHQRLD-SS---PDLPV---GAPRPPVDNYFQPT
DESGGS---QRVEAP-GEGTSSL----ERS-----EGRLFLESNSLCSSQQ---------
-----------SSKLQVGFLEQPPQQLQPPTTIR----------VPS---------KLPA
PPPRHE----SQRWAVRFVPEEVAS-TEHGPLSDTGP---SQWQSRPGNGGEAPTPLVEL
H-PTPPAVS-SWGG--L--------QHLSS--CPVSVLRD-----------PVGL-QGPA
LSPLPVCQPEGLLHP---SSQMCVAQEPQHHTLGDLPVHNKFSNWCGVQDGSPRGLGAAE
-DSGASCDLSS-GEQGL-RPPQP---------PEDRSQTPEWSQR------EQIPLQVGT
QSVSLSVELTEAKLHRGFGEADALLQVLQSGSGEALAPDGPVMSAWE--KLHARQ-----
----------KETIDTLRRERANRLQSFRRARSLSPQKQLSLLPSRGLPPQDLDLPSRRR
EYLQQLRKDVVETTRSPESAPR-AAHLPSDIELMLQEYQRAREEAKVEIAQARARLRERT
EQEKLRIRQQMVSQLLR-------EEVKLHMQANSSSLCSS-SNGSVSSGMTSGYNSSPA
-LAGQLQSPESVG-D------------------MNLSDS--RDTWLEDGRGRSAERSSHL
HLARSAWKGSAY-----SHRPAQGT--CCCS--------PTRLPSPATCF---SS-SYQD
LAKHVVDTSMADVMAACSGNLHSLFSRQAAAGWNYQGEEQEV---------QLYYKVFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSHVWAAVSDPTLWPLFHKPIQTARLFQQVTNSINLVYLVCN
TTTCALKQPRDFCCVCVEAKE------GPLCVMAAQSVYDASMPRPSKKMVRGEILPSAW
ILQPGTVQGKGVTRVVYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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----------------------------------ITKVQMSGLWLEG--VPQLQQ-----
----------KKTIETLRRERAERLHNFRRTRSLSPQKQLGFLPNKDLPTWEFDLPSRRR
EYLQQLRKDVVETTRIPEPTSR-SANLPSDIELMLRDYHQAREEAKVEIAQARDRLRERT
EQEKQRIRQQIISQLLK-------EEEKLQTLANSSSLCTS-SSGSLSSGITSGYNSSPA
-FSGHPQSLEVKE-D------------------SRVPDF--RDTWIGGWQGRSTVRNSQL
YLTGSTWKSLAH-----SRRASLGS--GCCS--------PFSLSSLGTCF---SS-PYQD
LAKHIVNTSMADVMAACSDNLHNLFSRQATAGWNYQGEEQEV---------QFYYKEFS-
-STRHGFLG--A

PF01852 // ENSGT00890000139327_7_Domain_2 (5653, 5806)

GVVSQPLSHVWAAVSDPTLWPLYHKPIQTARLHQRVSNSISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GHLSIMAAQSVYDTSMPRPSRKMVRGEILPSAW
VLQPVIMEGKEITRVIFLAQVELGAPGFPPHLLNSFIKQQPLVVAKLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQFASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFVREKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKSYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LSPLLWK-EGRVLEEQCDEDHPPPRDEETSHRAQIQ--QQQSYVKDLRHQIPAEEIRAEK
ELEFDQAWISQQIKENQQCLLREETWLASLQQQQ-QE---DHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KSVVQLQLLRRHTLQAAERNVRREMVS--FQLERIIKK
QRLLEAQKRLEKLTTLCWLQDDSTQEPPYQVHSPDA--TVPRPR-CRSKLTSCSSLSP--
QRLC---GKHVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EERLPQAASYPPRTGCLHKNSL-HSSGHGQPCTARAALARKGASAPDTCLTVSPNS----
-VGIQEMEMGVKPPHQMVSQGLASLRKSANKLKPRHE-PKILISATQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHKAA------KGASCNS---------LYPHGPRQTAGHGKAVK
TFW--TEYKPPSPSRASKRHQR--VLAARVRNITKKSSHLPLGSPLKRQQNTRDPDTMVP
LTDFSPVVDHSREKDNDLSDTDSNYSVDSLSCVYAKA-LIEPLKPE---ERRWDFPEPEN
SESDNSQPSEDSLAEKRYQSPKNRLGGNRPTNNHG----HPRTRTRASVRGFTA-PSDSD
LLAQTHRSFSLDSLIDAEE--ELGEDRQEEPFPGSADEIPTETFWHLEDSSLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QVEPSCSEQADSLQG-MQLSRES---PLMSMDSRFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHPCKGERPGYWPNTEELKPSDAETVL-PYSSKLHQDSTELPCNARDE------H----
-----------TAS-ASDMSRLSLWGIQRLI---QPG-----ADGTF--QGRCIPDTTQQ
GSCEASHNSSVSHVLTASGTTL---THVGSTHKRDW------SALQQKYLLECSRPVLEA
IGVPRP-----AFPYLEEDS--GSLAQSSSKGGDTLLPVGSRVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEASYDETFS----ADLESLSASRSTN--AQVFA
AENTIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSNEYFFQKNACHSNVT-T
ATKADHWSQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESFK-EAVRRHINVS-
--FAFPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVLS
PPPREAWGFGHNHQALQGAYLKNNLPVLLQNQNSKIASSQ-QVTA---EIPVDLNTREVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSITQNRHFLPST
STTVCEFENQVGILNKKHSF-PALEG---GE-VT-A------QSRCSVSSDSTES-----
-------------GKPLLLFRESESREEEEL----------------------------D
QNTVLRQTINVSLEKDMP--GESA----VSLKSRSVHHRVSSPVMVAQDGGPTPKW----
EGKNETGLVEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--SEC
KGPGK-SQE----MLNP--NGEPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGIDKELVFQDQ-KEQEKTDHALR---PDSSGNPLPSKDQPSSPRQTD
DTVFR--DSEAGEM--EVNS-IG-NHPQVQKIIL----NPFRSREGVQESEPVREHTH--
PAGSDRSARDIC--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALARALPLQPRLERSSENNG-QFGKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQKSQVAEHVSSS--------------NQEEPKAQGKVEEMPMQ
RGGSLQEENK----VTQKFPSLSQ-LCRDTFFSQETVSPLLSQTDFS-TAPSHQDL-SNT
LPLNSPRQQRRCLHVPV-ALGISPLD---RVLDLTMLKIHNGP-LVTGVEH-QDQSTETR
SHNPEG-NVR-----------------------------------GRSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--IPLGTEDRISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAIQKEIG-VSSLNKVSSQPEKRVSFCLEEDNDQASK-PRQK---AEKETEDL--
--GL----------------TSGVSLAPVSLP----------------------------
-RVPTPEPRLLE-PSDHASMCL-----AILEE----------IRQAETQRKQLNDFVARG
TVLSYCETLLELECSSRVAGRPQCKQID-----------QSSSDQTRNEGEAPGFHVASL
SAEAGQIDLLPDERK--VQA--------TPL-SADSFQSLPTMETDRE------------
-PWDPMQAFSHAAP--ALDKKHHTGEL-RQFAGASEPFICHSSSSEIIEKKKDATRTPSS
ADPLAPDSLLSSVPVEG--VRRVVSK-----------------------------KV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VLQETAEGIPPGSQDSSPEHQEP--RTVDTTYE-----------EVSDNLLVTAQG-
EK----------TGHFESQSVTCDVQNSTSASGPKQDHVQCPEASTGFEEGR-ASPKQDT
ILPGALTRVDL-----EAPTQQCVKWKESVGSGLTEV-CR--------------------
AGSKRSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRHPR
EALDGPAFSRNPEGSRTLSLSRGK-ESRTLPCQQPCSSQPV-ATHAYSSHSSTLLCFRDG
DL-KEPFEAAPHTIHPPCVVPSRACEMDETGEISSKGPNVHLTHGL----ELKDVNREFR
LTESSTCEPSTVAAVLSRAQGCRSPSA-PDVR-TSSFSHSATDGSVGLIGFPEKKVA---
---EKQAS--TELEAASFPADMYSEPLRQFRDSSVSDQNAQVSQ-TNPEPL--ATTQGPQ
TLDLSEGSAESKLVAE-PQHECLENT-TRCFLEKPQFPTELRDRNC-LDSQAKFLARLKH
TCSP--QED-SPWQEVEQQRDQAS-GGGEGFAQGVN-----PPPSDE-DGLDGCQILDAG
RE-----------------EVAVAKPPVSKILSQGFKGPAIVSLRQNETPQPAAQRSG-H
LYTGREQPAP-NHRGSLPVTTIFSGPKHS-RSTPTPQFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPNRLWNPHLRGYSSGKSVA------RTSLQAEDSNQKASSRLD----AGTTD
HRTLKPATPPY---PMPSTLSH-------MPTP---DFMTSWMSGTLE--QAQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLQFGSGDINPYALPWRPEEPARISWKQYVSGSAVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPFHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FQGSSSIALGDPHILTSPEGVAPTLG-HDRRPQFRGPSDEAD-CLRSKPPL--AEGSAAG
PVDEIMLLYPSEAGCPVGQ-TRTNTFEHGTQTLG-SR-------CHWSSTDIYFAQPEAS
VVSAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASS----------TLCLQ-TSEAESQGANV-ILEGLGS-
---DTSTVC----------QEEGDVPGVPQKREV-EDKAQK-MAQ-----LLYLQ-----
-EESTPYKPQSPSIP-SSHLRFQKAPVG--QHLPSVSPSVSDAF-LPPSPQPEESYCLVV
SSPSP--SPSPSHSPGLFPST-SEYPGDS--RLQKKL-GPTSVLLVDRASSPILTLSASI
QEPGL-PPGSLTLSALSA----YPVEGHQKLD-SS---PDPVG-A--PRTP-MDNYSQTT
EELGGS---QRG-------RSSL----QRS-----NERSFLELHSLHSPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTIGVQS-------------------RLLP
PPLRHG----SQRLGDSFVPEEVAS-PEHGPLSGREP---SQWQSRTENGGESSGSPGEP
Q-CILDRPS-SWGG--L--------QHLSP--CPVSELTD-----------TAGF-QGST
LGLPQACQPEELLCS---SCQMCMAPEPQHHSLRDLPVHNKFSNWCGVQKGSPGGLDLTE
-ELGASSDLSS-EKQ-EQSPPQP---------PNDHSQDPGWSKR------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELYARQ-----
----------KKAIETLRRERAERLGNFCRTRSLSPQKQLSLLPNKDLFIWDLDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAHTPSDVELMLQDYQQAHEEAKVEIARARDQLRERT
EQEKLRIHQQIIS--QLL-----KEEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQFPENVG-H------------------TNLPDS--RDVWIGDERGGHSAGR---
-------KNSAY-----SRRASLGS--CCCS--------PSSLSSLGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQQVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPITVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 431)

RVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDSRPDGFGDSREKVIAFG
FDYCYWSVNPEDPQYASQDVVFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRQKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTVYYTQ--------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------D

ENSGT00890000139327_7_Linker_0_1 (431, 545)

ANVKLIRELREEIERLKALLLSFELRNF-SSLNDEKDENLKELVLQNELK
VDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDGDCQPPRDGETSHGAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQTWISQQIKENQQCLLREETWLARLRQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPWPQ-CRSKLTSCSSLSP--
QRLY---SKYVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLRKNVL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLGKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASCNS---------PYPHGSRQTAGHGKAVK
TFW--TEYKPPSPSRASKRRQR--VLAARVRNTTKKSSHLPLGSPFKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERTWDFLEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNNHG----HPRTRTRASVRGFTA-PSDND
LLAQTHRSFSLDSLIDAEE--ELAEGQQEEPFPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRESPLSPLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFHPCKEERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCISRDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCICDMTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSRPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGKGGDTPLPIGPKVSSNLNLNSFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQDAYLKNNLPVLLQNQNSKVASSE-QVTA---EIPVDLNTEEVI
RESDKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSYCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVMRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPVMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
KGPGK-SQE----MLNP--NGEPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
VTVFR--DSEAGEM--EVNS-TG-NHPQVQKITP----NPFRSREGVQESGPVREHTH--
PAGSDRPARDIF--DS--------------LGKYTTCRE-----FTNTSLHPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKGQPWGL
GRLEELETV-----KGFQESQVAEHISSS--------------NQEEPKAQGKVEEMPIQ
RGGSLQGENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTELS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVDH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--ISLGTEDRISASTSP-QDHGKDLKITLLGFSTSEDF
ASEAKVPMQKEIG-VSSLNKVSSQPEKRVSFSLEEDNDQVSK-PRQK---AEEETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVAGG
TVLSYCETLLEPECSSGVAGRPQCKQID-----------LSSSDQTRNEGEAPGFRVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPSTETDRE------------
-PWDPVQAFSHAAP--ALDKKHCTGEQ-RQFAGTSEPFICHSGSSEILEKKKDATRTPSS
VDPLAPDSLLSSAPVEG--VRRV-------------------------------------
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RTLNTTYG-----------EVSGNLLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
ILPGALTGVEL-----EAPTQQCVNWKESVGSGLTEI-CG--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEEIGEG-APCRYPR
EALHDPVFSRNPEGSRTLSTSRGK-ESRTLPCPQPCGSQPV-ATHAYSSHSSTLLCCRGG
DLGKEAFKAALRTVHPPCGVPSRAYEMDETGETSSRGPDVHLTRGL----EPKDVIREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATNGSLGLIGAPEEKVA---
---EKQAS--TELEAASFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
ILDLSEGSVESKVVAE-PQHECFENT-TRCFLEKPQFSTELRDHNC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGVN-----PLPSNE-GSLDSCQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVAQGPG-N
LYTGREQPAL-NHRGSLPVTAIFSGPEHS-KSSPTPQFSVVSSSHSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKAVA------RTSLQAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QAQQ-GKPEK
LGIQVRPENWCSQ-MDKGMLHFGSSDINPYALPWRTEEHAHISWKQYVFGSTVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPFHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSIALGDPHILTSSEGVAPTSG-HDRRPQFRSPSGEAG-CLRSKPPL--AEGSTAG
PVDEIMLLYPSGAGCPVGQ-TRTNIFEQGTQTLD-SR-------CHQSSTDISFAQPEAS
AVSAS-DLASWTSMHSLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKASQ-
-ALMMDGSTQTTVDEGSQTDLATP----------TLCLQ-ASETEPQGANV-ILEGLGS-
---DTSTMS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPLTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEESSCMAV
SSPSP----SPCHSPGLLPNT-SEYPGDP--RVKKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSAL----QRS-----NGTSFLEVHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTTGVQS-------------------RLQP
PPLRHR----SQRLADSFVPEEVTS-PEHGPLSGREP---SQWRSRTENGGESSASPGKP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKGSPGGMDMTE
EELGASGDLSS-EKQ-EEGTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAVETLRRERAERLGNFCRTRSLSPQKRLSLLPNKELFIWELDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLQDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIISQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGHLQSPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

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--------------------------

PF00225 // ENSGT00890000139327_7_Domain_0 (87, 409)

TEVLSGAAKGYNMCLFAYGQTGSGKTYTMLGTPV
ALGLTP-RICE-----------------------------GLFIREEDYPSLPSSCGIKI
SFLEIYNERVRDLLMQPDQKKSHTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RVTAATHVHETSSRSHAIFTICYTQAVLENNLPSETASKISLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSCCQSLIRAA-SDGDDGGIPSSSSGTSSG
GRTSRRQSYIPYRDSVLTWLLKDCLGGNSKTIMVASEWGPEDGSMGLVS----ASET-G-
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PF00225 // ENSGT00890000139327_7_Domain_0 (87, 402)

TEVLSGAAKGYNVCLFAYGQTGSGKTYTMLGTPX
XXXXXXXXXXX-----------------------------XX-XXXXXXXXXXXXXXXXX
XFLEIYNERVRDLLKQPDHKKSYTLRVREHPEMGPYVQXXXXXXXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXAILENNLPSEIANKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLSSTA-SDGGERGIPSPPSGISRG
GGTSRRQSYIPYRDSVLTWLLKDCLGGNSKTIMVASEWNKLVLFWDWYSALE--------
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--------------------------------------M

PF00225 // ENSGT00890000139327_7_Domain_0 (280, 421)

ASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTSSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
IDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDRQPLRYGETSHRAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQTWISQQIKENQQCLLREETWLASLQQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPQPQ-CRSKLTSCSSLSP--
QRLC---SKHVPQLHS-------------IFLSWNPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLRKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLRKSANKRKPRHE-PKILTSTTQTGGAKGLADP---
-SHTQAGWRKEG-NLGTHTTA------KGASCNS---------SYPHGPRQTAGHGKAVK
TFW--TEYKPPSPSRASKRHQK--VLAARVRNITKKSSHLPLGSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKT-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNHHG----HPRTRTRSSVRGFTV-PSDSD
LLAQTHRSFSLDSLIDAEE--ELAEDQQEEPFPGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPVNYRTA-ARLDAVLPMNSSFYLDPQFQPHCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHHCKGERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCIHDTTQQ
GSSEASHNSSVSNALSASATTL---THVGGTHERDW------SAFQQKYLLELSRPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGEGGDTPLPVGPKVSSNLNLNNFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPDSMT-----EACEVKQNNLEE-RLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SQ-YPLEEEKTDCQESSQ-EAVRRHINIS-
--FAFPSGPELYLHSAAWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNGQALQDAYLKNNLPVLLQNQNSKVASSQ-QVTT---EIPVGLNAGEVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACKEEDL----------------------------D
QNTVLRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPVMVAQDESPTPKW----
EGKNEIRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
KGPGK-SQE----MLNP--NGEPSEKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQAHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQAD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPVREHTH--
PAGSDRPTRDIF--DS--------------LGKHTTCRE-----FTNTSFRPQR------
------------MKALTRALPLQPRLERSSEDNG-QLVKA-----S--AS--LKEQPWGL
GSLEELETV-----KGFQESQVAEHLSSS--------------NQEEPKAQGKVEEMPMQ
RGRSLQEENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTEFS-TAPLHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVAGVPH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMRSHSQSGVPES--ISLGKEDKISASTSP-QDHGKDLRITLLGFSTSEDF
ASEAEVAVQKEIG-VSSLNKVSSQPEKRVSFSLEKDNDQASK-PRQK---AEEETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSQEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECCSGVAGRPQCKQIE-----------LSSSDQTRNEVEAPGFHVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPNTESDRQ------------
-PWGPMQAFSHAAP--ALDKKHCTGEL-RQFAGTNEPFICHSGSSEILEKKEDATRTPSS
VDPLAPDSLLSSAPVEG--VRRVVSK-----------------------------QV---
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RALNTTYR-----------EVSGNSLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
ILPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPW
EALHGPVFSRNPEGSRTLRTSRGK-ESRTLPCRQPCSSQPV-ATRSYSCHSSTSLCCRGG
DLGKEPFKAALHTVHSPCGVPSRAYEMDETGETSSRGPDVLLTHSL----EPKDVNREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---ENQAS--TGLEAASFPAGMYSEPLRQFRDSSVGDQNVQVSQ-TSPEPP--ATTPGPH
PLDLSEGSVESKLVAE-PRHECFENT-TRCFLEKPQFSTELRDHDC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVSQGPG-N
LYTGREQPAL-NHRGSLPVTAIFSGPERS-KSSPTPRFSVVSSSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRAYSSGKSVA------RTSLQAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QAQQ-GKPEK
LGVQVRPENWCSQ-MDKGMLHFGSSAISRYDLPWRPEEHARIGWKQYVFGSTIDVSCSQK
PQGLTPSNVARCSS--VDNGLEDQNSCFHSHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSISLGDPHILTSSEGVAPTSG-HDRRPRFRGPSGEAD-CLRSKPPL--AEGSAVG
PADEIMLLYPSGAGCPVGQ-TRTNIFKQGTQTLG-SR-------CHQSSTDISFAQPEAS
AASAS-DLASWTNMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKAPQ-
-ALMMDGSTQTTVDEGSQTDLASP----------TLRLQ-ASEAEPQGANV-ILEGLGS-
---HTSTVS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLGFQKAPLR--QHLPSVGPSVSDAF-LPPSFQPEESSCIAV
SSPSP----SPCHSPGLLPST-SQYPGDP--RVQKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSAL----QRS-----NGRSFLELHSPHNPQQ---------
-----------SPKLQLSFLGQHPQRLQPRTTIGVQS-------------------RLLP
PPLRHR----SQTLADSFVAEEVAS-PERGPLSGGEP---SQWRSRIENGGESSTSPGEP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKGSPVGVDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAIETLRRERAERLGNFCWTRCLSPQKQLSLLPNKELFVWDLDLPSRRR
EYLQQLRKGVVETTRSPESVSR-LAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIVSQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQSPENAG-Y------------------TNLPDS--RDVWTGDERGGLSAVR---
-------RNSAY-----SRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSHVWAAVSDPSLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVRVAVRVRPLSKRETKEGGRIIVEVDGKVAKIRNLKVDNRPDGFGDSREKVMAFG
FDYCYWSVNPEDPQYASQDV---------------------------------------A

PF00225 // ENSGT00890000139327_7_Domain_0 (121, 421)

SVGLTP-RICE-----------------------------GLFIRQKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIRLLEEGIA
N--RITAATHVHEASSRSHAIFTIHYTQAILENNLPSEMVSKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTTSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-GSLNDEKDENLKELVLQNELK
VDQLTKDWTQKWNDWQALMEHYSVDINR-RAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5652)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDEDCQPPRDGETSHGAQIQ--QQQSYVEDLRHQILAEETQAEK
ELEFDQTWISQQIKENQQCRLREETWLASLRQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDAEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAEQDVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPGA--TVPRPQ-CRSKLTSCSSLSP--
KRLC---SKDVPQLPS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLHKNGL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLRKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHMAA------KGTSCNS---------PYPHGSRQTAGHGKAVK
TFW--TEYKPPSPSRASKRHQR--VLAARVRNITKKSSHLPLDSPLKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DSDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERKWDFPEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNNHG----HPRTRTRASVRGFTV-PSDSD
LLAQTHRSFSLDSLIDAEE--ELVEGQQEEPFPGSADEIPTETFWHLEDSSLPVMDQ--E
AICRLGPINYKTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRES---PLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDVQ
EFHPCKEERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCIARDE------H----
-----------TAS-ASDTSRLSLWGIQKLS---QPG-----ADGTF--QGRCIRDTTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSCPVLEA
IGAPRP-----AFPYLEEDS--GSLSQASGKGGDTPLPVGPKVSSNLNLNNFPIHQSRIR
RLRAEKEQDSLNAKLEGVSDFLSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLNPE--SH-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNRQALQDAYLKNNLPVLLQNQNSKVASSQ-QVTA---EIPVDPNTREVI
RESGKCPGNIT-E-----ESY----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILNKKHSF-PALEG---GE-VS-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVLRQTISVDLEKDLP--WESA----VSLKSRSVHHRVSSPVMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTCPQ-ERNP--GEC
KGPGK-SQE----MLNP--NGEPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALK---PDSSGNLLTAKDQPSSPRQTD
ATVFR--DSEAGEM--EVNS-TG-NHPQVQKITL----NPFRSREGVQESGPVREHTH--
PAGSDRPARDIF--DS--------------SGKHTTYIE-----FTNTSLRPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKGQLWGL
GSLEELETV-----KGFQESQVAEHISSS--------------KQEESKAQGKVEEMPMQ
RGGSIQEENK----VTQKLPSLSQ-LCRDAFFSQETVSPLLSWTEFS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVDH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMGSHSQSGVLES--ISLGTEDRISASTSP-QDHGEDLRITLLGFSTSEDF
ASEAEVPMQKEIG-VSSLNKVSSQPEKRVSFCLEEDNDQASK-PKQK---AEKETEGL--
--GL----------------TSGVSLAPVSLP----------------------------
-RAPSPEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVARG
TVLSYCETLLEPECSSGVAGRPQCKQID-----------LSSSDQTRNEGEAPGFRVTSL
SAEAGQTDLSTDEKK--VQA--------TPL-SADSFQSLPNTETDRQ------------
-PWDPVQAFSHAAP--ALDKKHCTGEL-RQFAGTSEPFICHCGSSEILEKKKDATRTPSS
VDPLAPDSLLSSAPVEG--VRRV-------------------------------------
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RTLNSTYG-----------EVSGNLLVTAQE-
EK----------TAHFESQSVTCDVQNSTRPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
ILPGALTGVEL-----EAPTQQCVKWKESVGSGLTEI-CR--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEGIGEG-APCRYPR
EALDGPVFSRNPEGSRTLSTSGGK-ESRTLPGRQPCSSQPV-ATRAYSSHSSTLLCCRGG
DLGKEPFKAALRTVHPPCGVPSRVYEMDETGETSSRGPDVHLTHDL----EPKDVNREFS
ITESSTCEPSTLAAILSGAQGCRSPSA-SDVRRTSSFSHSATDGSLGLIGAPEKKVA---
---EKQAS--TELEAASFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
TLDLSEGSVESKMVAE-PQHECFENT-TRCFLGKPQFSTELRDHNC-LDSQAKIVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSDE-GGLDSCQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNKTPQPVAQGPD-N
LYTGREQPTL-NHRGSLPVTAIFSGPEHS-KSSPTPQFSVVSFSRSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKAVA------RTSLQAEDSNQKASSHLD----DGTTD
HKPLKPATPPY---PVSSTLSH-------MPTP---DFMTSWMSGTLE--QAQQ-GKPEK
LGVQGGPENWCSQ-MDKGMLHFGSSDINPCALPWRPEEHAHTSWKRYMFGSTVDVSCIQK
PRGLTPSNVARCSS--MDNGLEDQNSPFHSHLSTYASIRDLSTTHS-TENAQGSNEAWEV
FPGSSSIALGDPHILMSSEGAAPTSG-HDRRPQFRSPSGEAD-CLRSKPPL--AEGSAAG
PVDEIMLLYPSGAGCPVGQ-TRMNIFEQGTQTLG-SR-------CHQSSTDISFAQPEAS
AVSAS-DLASWTSMHNLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKASQ-
-ALMMDGSTQTTVDEGSQTDLTSP----------TLCLQ-ASEAEPQGANV-ILEGLGS-
---DTSTMS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPSTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEEPSCIAV
SSPSP----SPCHSSGLLPNT-SEYPGDP--RFQKKL-GPTSALLVDRASSPILTLIAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSAL----QRS-----NGTSFLEVHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTIGVQS-------------------RLLP
PPLRHR----SQRLADSFVPEEVTS-PEHGPLSGREP---SQWRSRTENGGESSASPGKP
Q-CTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLLAHNKFSNWCGVQKGSPRGVDMTE
EELGASGDLSS-EKQ-EQSTPQP---------PNDHGQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLQSGTGEALAADEPVISAWK--ELHARQ-----
----------KKAVETLRRERAERLGNFCRTRSLSPQKRLSLLHNKELFVWELDLPSRRR
EYLQQLRKDVVETTRSPESVSR-LAQPPSDIELMLRDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIISQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGQLQSPENAG-Y------------------TNLPDS--RDVWIGDERGGLSALR---
-------KNSAC-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWSYQGEEQAV---------QLYYKVFS-
-STRHGFLG--

PF01852 // ENSGT00890000139327_7_Domain_2 (5652, 5806)

AGVVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS

--MANVQVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 421)

RVRPLSKRETKEGGRIIVEVDDRVAKIRNVKVDSRPESFGDTREKVVAFG
FDYCYWSVNPEDPHYASQEVVFRDLGTEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIAEDDCASLPYSRSIKV
SFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHVVTNYQQAIQLLEEGVA
N--RITAATHVHEASSRSHAIFTIHCTQAVLQNSLPSETASKINLVDLAGSERADPSYCK
DRITEGSNINKSLVTLGIVISTL-AQNSQVFSSCQSLSSAA-SSGGDSGVPSTTSGASSG
GGSARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKAMLLNFEL-------------------------
IDTLTQHWTEKRNDWQALMEHYGVDINRKRARVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIEKDHCTITSTCGVVILRPTQGARCTVNGREVSASCR
LTQGAVITLGKAQKFRFNHPAEAAVLRHQRLKVGEALGSS--GSLEWLDLDGDVSASRLG
LCPVLRK-ERRVLEEQSDKDQQPSRNGEIPSRAQTE--QQQCHVEALTQQA-KGQCRVQK
ELELDHTHISRQRNDNQQWLLKEETWLASLRETQ-QE--GYCGEEK--------ELVASV
APDAWLPTVAQTPPSPLVQSQ-KRVVQPQCSPRHTSRATVWNIRQKKVS--FQLERIIKK
RRLLEARRRLEQLSALFWVQDGGASRAPGWAPSSNT--SGPGSQ-RSSRRTTCSSLS---
-------RRRLPQLHS-------------AFMNWDPSAMSPPVPELTH----QMLEKSLS
TDFI------PPRAGRLGRNSL-HSLWWRKFSPARRA------STQSTHLTVSHKS----
-VSSQEIESLGKQPCQMSSQGQ-----STKKQKTRDG-SRTFIPS--STWAKGLTAS---
-VSTQTGWTKEG-SCGTYKTP------KETTSQS---------TDLSGLEPAAGHRKVVK
SFQ--AESKPPPPSRASKKHPR--ALAARARDFAKTFSRLPQGSPLKDQPRAGHPDTPAS
FTDSRPIKGRVREEDRGLSDTESSYSVDSLSYVCAQV-PEKLLKPEGLQ-GKWKLPDPEN
SESDNSQISEDSIAGKGHGSLSTNSRGEYSMKDHG----HSRARTSASVRGLPM-PSDSN
LYTQKYRSFSLDSLIDPEN-------RQGEPFLGSADEMPTETFWHLQNATLSSVDQ--E
AMARSSPTNHRMG-VGVNVLLPKSNSFYLDPQFQP------------------SCDQLES
EMEASYSEHTNPLRG-IQLARES---PLLSVDSWFSCDSKISPSSPSGVIHSLCPNPDIH
EIQPHG-EKPKHWLSIEEVKP--------LGTCKLPQSSTEPPCSS-DL------Y----
-----------ATS-VSDTSKPSVSESQGLL---QPG-----ADGFF--QGREMPDMTNQ
GISEESHNSDMSSMLAPSTTSF---THVCSINKKDW------AALHQEYLLELSDSGFEA
VGEPRP-----AFPFLEEDS--SSLTEASDR-VDTHLPTGPGLSRNLDFSSFPVHISKMG
HLRTEKDHDSRSAKVESASDLFSTVER-MSSNGTYP----ADVESLT-SGSIN--AQPYT
AGNVMPSSMT-----EAWEVSHASLEG-CLQGG-RHSALITSSG----QKRAYHNHDT-L
ATEGDCLPQVGALLRKNTTVQPGLLSHS--GHQHPLLEEEAASQQCTDEEVARAHIDAC-
--CTFPSGPELFLHSAHWSSFPSS-LQPPPLETFYVTKSRDALTETALEIPACREAWVPS
PPPREAWGFGHSHQISQKAHWKKNLPKLSPSQNSKIDLPQ-QT-T---KRPTDLDTGEGT
EELGKHSRNMREE-----ENH----------------------DSADSLVAQNRQHLPPT
KSKACECGNHLGILNKEYTLSVHENP---EG-AS-A------WHHCSVAFNGSE------
-------------SKTLLFICDSKASGEEQSP----------LLPQIQSGGMRSQS-PGA
RSDFIGKITNLDLEKVIP--DETA----VSLKSRSLHCL-SSPVSLAGGGSPTHRW----
EGTNETVLLRD-VISKDIQEEFSLPGTQY-------ICER--CHLVICSQ-EREP--TEC
KAHGQ-SQE----V-RS--KEEPLEEKQNERVN--HIDEMARLIRSVMQ--LETGILEIE
SKQNKQLHASHRPST--ELMLQDL-EGKEKADHVPK---PESSGEHLCFEDQPSFPIQIK
GGIFE--DSSTREV--EVNNTTSNNNTQIQKL---------RSREYVQTRGSESEPSCP-
PPGADRLARDTC--DS--------------LGKGTALRK-----PSNISLHSRT------
------------MRALARALPLQPSIERHE-KDN-ELLKA-----S--AK--FQGQTWSL
ESLEELESM-----ESFQESQIVVVPSGS--------------ELENAKTQGGVEEMTVD
RRGSLQEKEA-MVSSIQKVSTPSQ-HWKGTFFSQEAVSPFHNQTAFS-AALPHGEL-SGT
QPVHSLGFPRSGLHGSD-TKGISSFE---YILEPVMLKTNRNS-LATGVGD-QDHIGETR
SRSPQE-SAS-----------------------------------GDVSTTHTPWGGSVM
PV-------VMRANGQTVTPDS--TLLNAEDWITVSTSSQEDQEGGFRDTSTGSATQETL
DSEAEATVQKERK-TSSLDRISRQAEKRVSFLLQEDSNQGEE-ERQK---AEEKSEDQ--
--QL----------------PNSAYLTPVSVL----------------------------
-KGPDPEPLLLPDSSIHASLCL-----GILAE----------IRQAKAQRKQLNDFVAEG
TALPYE-TSQEAECFSEAAGKPQTQKAR-----------L-GWDSARNDAKVQRLHEASP
TAVS--ADLLADERK--AQA------------TAGSFHHLPNPETDRE------------
-PQHHLLASPHVVS--ELEERYCTGKP-RQFCGASGW----SDSSEVIEIRKEASRTKSS
VGPLPSDRLLSIPAAEQ--DGRVGSE------------------------------K---
----------------------------------VSVLPSQTSCDAPGRILH-----GQG
QL-AAQEIVKGISFGGKDSIQGHQEP--RSLDSTHG-----------GGSGKISLTTQK-
GK----------AVFSECLSVMCTVDNAVDLSRPKQDHVHGLDASTGLEEMK-ASPKSCA
VHPEAPRKVEG-----EANIRHPVKWKN-VHSGLAVA-CG--------------------
GDSKNPW--ST------------------------PFLDQRPSLHPSGVREE-APGPCPK
D---CLVFERNTGGSRPLGSSYEEAENRTIPCPHLSGSQPIAAVYACCSHSSPLPCYRDG
VLRKGTPWAAPHPDHSPCIVPSRVCEVDGAGESFSP---VSLAHGL----KHK-----CG
SVDNSIPNPPTTTPVSSPAQNCSCLSI-SAMR-ASSLTHTFARGRS-VEGSGEE-TT---
---GNKASTAPEDTFPSSPAGMSSEPLRTLKNNSVD-ENGQASQ-TMPEPL--AVTQGPR
TLNAN-ESVDSKLVIA-AQFGHLENT-IKCCSEKMQPSTKVRGHSC-SGPQAQFVTMLKP
TCHP--KIE-TSWEEEEQQRDQVS-GDGKDHAQVRN-----LVPSNV-GGFDGCQTRDGE
T-----------------------KSSVPQTFFSDFE-------AQTEPSQPAAQTHS-Q
HCSDRKQLPRSHHRHLLPVIAIFSGPKHA-KYSPSPKFHMVSSSRSLQELNLS-VEPPSP
TNKDA-QGPDSLWRPHLRGHSSEKPVS-------TSLKTQDYSQKALCNLN----NSSTD
HRSLNPVIPPY---PTSSTVSC-------MPTP---EFLTTWMPGALE--QAHQ-GKKDK
LSVQCMPENWHSQ-TDKEMLHFGSSELSPSVLPSCPQGPVHIGWKQYVFGSAVDVSCSQK
PQCLIQSNMAQHSS--MDNVLEVKKSPFHSHPKSDAQTQDLPNIHSNIENDQSSN-----
-----------------------------------------------ELPL--AGGSATA
QVDEIVLLCPTETGCAGAE-ASMNTFEQRTQALG-SR-------CHWSCTDVSV-QPEAR
TMSDS-ELASWTSMHNLSVHLSQLLHSTSELLGSLSHPGVVMKEQNVK--SESLDEAQQ-
-ALIRDGSALTTVDEGIQTDLALP----------PLAFQ-NPEIKSEEVSV-ILEVMDS-
---GITTVA----------QEKGDVPVVFQKREA-EEAA-----A-----PLGLH-----
-EGSTHDKLQNPPVPPVPHLRFQKADLG--QNFTFMSPPASPDG-SPPPSLQPEESCMVV
NMPR------ISPHSGLFLGA-SESTQEP--KTQKRW-CGSSAVLVDRASSPILTFSASI
QELSK-PLACVTLSVPSA----HPLEDFQKL-DIN---SDLAV-G--DPRPPVDNS-QAS
DESGDS---QRAESLDRGGKSPL----GKS-----PERLLLDTSSPCSPQQ---------
-----------SSSLQVSVLGTAPQQLQPESTTGDQS-------------------KLPS
PPPGHR----NPKLDDSCVTEKVTS-IEHGPL---RP---SQWQSRAAN--KGSEFMVVP
Q-PNLNQPS-SRRG--L--------QPVSP--CQISD--------------STGI-QSPA
VDPPQACHPVGLLCS---GSHMHVAPGPQHYNLRDPPVHNNFNNLYGVQKGPCGGLHVGK
-SLEVRCDSSS-VG--TQRPQQP---------SEKYSQNLDWLQL------EHIPLQAGV
QKLSLSVELTEAKLHHGFGETDALLKALQSGTGEMLAPQEPAVPSSE--GFYTRQ-----
----------KKTLETLRRQRAERLHNFRRTRSLSPQK-LGFLPSKDFPTWELDLPSRRQ
EYLQQLRKHVVDITRIPEPAPR-LARPPSDIELMLQEYHRAREEAKAEIAQAQNRLKERT
EQEKMRIRQQIIS--QLL-----KEEEKLQTLANFSSLYTS-SNGSISSGVTSGYNSSPA
-FSGHLQSLEVSE-D------------------SQMPDS--QDTWIGDWRGRSTVRNSYL
YLTGSSWKSLAH-----SRRASMGS--GCFS--------PSSLSSLGTCF---SS-PYQD
LAKHIVNTSMADIMAACSDNLHNLFIRQATDGWNYQGEEQEV---------QLYYKEFS-
-STRHGFLG--ASLVSQPLSQVWAAVSDPTLWPLYHKPIQTARLHQRVTNSISLVYLVCD
TTLCALKQLRDFCCVCVEAKE------GCLSIMAAQSVYDASMPRPSRKMVRGEILPSAW
VLQPVIIEGKEITRVIFLVQVELGAPGFPPHLLNSCIKQQPLVVANLASFLRS

--MANVRVAV

PF00225 // ENSGT00890000139327_7_Domain_0 (11, 287)

RVRPLSKRETKEGGRIIVEVDGKVAKIKNLKVDSRPDRFGDSREKVVAFG
FDYCYWSVNPEDPQFASQDVIFQDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTMLGTPS
V-GL-T-RICE-----------------------------GLFIKEEDYASLGSSCRIKV
SFLEIYNERVRDLLKQSDQKKSFTLRVREHPEMGPYVQXXXXXXXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXAILENNLPSEIASKINLVDLAG----------
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PF00225 // ENSGT00890000139327_7_Domain_0 (81, 421)

VFQDLGMEVLSGVAKGYNICLFAYGQTGSGKTYTMLGTPA
SVGLTP-RICE-----------------------------GLFIRQKDCASLPSSCRIKV
SFLEIYNERVRDLLKQSGQKKPYTLRVREHPEMGPYVQGLSQHVVTNYKQVIQLLEEGIA
N--RITAATHVHEASSRSHAIFTIYYTQAILENNLPSEMASKINLVDLAGSERADPSYCK
DRITEGANINKSLVTLGIVISTL-AQNSQVFSSCQSLNSSV-SNGGDSGILSSPSGTRSG
GAPSRRQSYIPYRDSVLTWLLKDSLGGNSKTIMVATVSPAHTSYSETMSTLRYASSA-KN

ENSGT00890000139327_7_Linker_0_1 (421, 545)

IINKPRVNEDANVKLIRELREEIERLKALLLSFELRNF-SSLNDEKDENLKELVLQNELK
VDQLTKDWTQKWNDWQALMEHYSVDINRRRAGVVIDSSLPHLMALEDDVLSTGVVLYHLK
EGTT

PF00498 // ENSGT00890000139327_7_Domain_1 (545, 610)

KIGRIDSDQEQDIVLQGQWIERDHCTITSACGVVVLRPARGARCTVNGREVTASCR
LTQGAVITL

ENSGT00890000139327_7_Linker_1_2 (610, 5654)

GKAQKFRFNHPAEAAVLRQR-RQVGEAAAGG--GSLEWLDLDGDLTASRLG
LFPLLWK-EGRALEEQCDGDCQPPRDGETSHGAQIQ--QQQSYVEDLRHQILAEEIQAEK
ELEFDQTWISQQIKENQQCLLREETWLARLRQQQ--Q--EDHVAEK--------ELEASV
ALDAWLQTDPEIQPSPFVQSQ-KRVVQLQLLRRHTLRAAERNVRRKKVS--FQLERIIKK
QRLLEAQKRLEQLTTLCWLQDDSTQEPPYQVPSPDA--TVPRPQ-CRSKLTSCSSLSP--
QRLY---SKYVPQLHS-------------IFLSWDPSTTLPPMPDPTH----QTSEKTSS
EECLSQAASYPPRTGCLLKNVL-HSSGHGQPCTARAALSRKGASAPDTWLTVSPNS----
-VGIQEMERVGKQPHQMVIQGLASLGKSANKLKPRHE-PKILTSTTQTRGAKGLADP---
-SHTQAGWRKEG-NLGTHTAA------KGASCNS---------PYPHGSRQTAGHGKAVK
TFW--TEYKPPSPRRASKRRQR--VLAARVRNTTKKSSHLPLGSPFKRQQNTRDLDTMAP
LTDFSPVVDHSRE-DNDFSDSDSNYSVDSLSCVYAKA-LIEPLKPEDPQERTWDFLEPEN
SESDDSQISEDSLAEKRYQSPQNRLGGNHPTNNHG----HPRTRTRASVRGFTA-PSDND
LLAQTHRSFSLDSLIDAEE--ELAEGQQEEPFSGSADEIPTETFWHLEDSNLPVMDQ--E
AICRLGPINYRTA-ARLDAVLPMSSSFYLDPQFQPRCELQP------------HCEQAES
QGEPSYSEQANSLQG-MQLSRESPLSPLMSMDSWFSCDSKINPSSPPGIVGSLCPSPDMQ
EFHPCKEERPGYWLNTEELKPSDAETVL-PYSSKLHQGSTELLCISRDE------H----
-----------TAS-ASDTSRLSLWGIQKLI---QPG-----ADGTF--QGRCICDMTQQ
GSSEASHNSSVSNVLSASATTL---THVGGTHERDW------SALQQKYLLELSRPVLEA
IGAPRP-----AFPYLEEDS--GSLAQASGKGGDTPLPIGPKVSSNLNLNSFPIHLSRIR
RLRAEKEQDSLNAKLEGVSDFFSTSEKEVSYDETYS----ADLESLAASRSTN--AQVFA
VGNTIPDSMT-----EACEVKQNNLEE-CLQSC-RKPGLMTSSDEYFFQKNACHSNVT-T
ATKADHWPQGWAPLRKNSAVQPGQLSPD--SH-YPLEEEKTDCQESSK-EAVRRHINIS-
--FAFPSGPELYLHSAPWNPLSSS-LQPPLLETFYVTKSRDALTETALEIPACREVRVPS
PPPREAWGFGHNHQALQDAYLKNNLPVLLQNQNSKVASSE-QVTA---EIPVDLNTEEVI
RESGKCPGNIT-E-----ESH----------------------DSVYSSVTQNRHFLPST
STKVCEFENQVGILN-KHSF-PALEG---GE-VT-A------QSCCSVSSDSTES-----
-------------GKPLLLFLESEACEEEEL----------------------------D
QNTVMRQTINVGLEKDLP--WESA----VSLKSRSVHHRVSSPVMVAQDESPTPKW----
EGKNETRLLEKALHPKDSSEEFKLPGTKP-------AYER--FQLVTRPQ-ERNP--GEC
KGPGK-SQE----MLNP--NGEPSGKKQNKRVN--NTDEMARLIRSVMQ--LENGILEIE
SKQNKQVHASHTPGVDKESVFQDQ-KEQEKTDHALR---PDSSGNLLTSKDQPSSPRQTD
VTVFR--DSEAGEM--EVNS-TG-NHPQVQKITP----NPFRSREGVQESGPVREHTH--
PAGSDRPARDIF--DS--------------LGKHTTCRE-----FTNTSLHPQR------
------------MKALTRALPLQPRLERSSENNG-QLVKA-----S--AS--LKGQPWGL
GSLEELETV-----KGFQESQVAEHISSS--------------NQEEPKAQGKVEEMPIQ
RGGSLQGENK----VTQKLPSLSQ-LCRDTFFSQETVSPLLSWTELS-TAPPHQDL-SNT
LPLNSPRRPRSCLHVPG-VLGISSLD---CVLDLTMLKIHNSP-LVTGVDH-QDQSTETR
GHSPEG-NVR-----------------------------------GGSSEAHTAWCGSVR
SM-------AMGSHSQSGVPES--ISLGTEDRISASTSP-QDHGKDLKITLLGFSTSEDF
ASEAKVPMQKEIG-VSSLNKVSSQPEKRVSFSLEEDNDQVSK-PRQK---AEEETEDL--
--GL----------------TSSVSLAPVSLP----------------------------
-RVPSPEPRLLE-PSDYASMCL-----AILEE----------IRQAKAQRKQLNDFVAGG
TVLSYCETLLEPECSSGVAGRPQCKQID-----------LSSSDQTRNEGEAPGFRVASL
SAEAGQTDLSTDERK--VQA--------TPL-SADSFQSLPSTETDRE------------
-PWDPVQAFSHAAP--ALDKEHCTGEQ-RQFAGTSEPFICHSGSSEILEKKKDATRTPSS
VDPLATDSLLSSAPVEG--VRRV-------------------------------------
----------------------------------VAALSSQAPCDDPRVTLH-----ELS
QS-VPQETAEGIPAGSQDSSPEHQEP--RTLNTTYG-----------EVSGNLLVTAQE-
EK----------TAHFESQSVTCDVQNSTSPSGPKQDHVQCPEASTGFEEGR-ANPKQDT
ILPGALTGVEL-----EAPTQQCVNWKESVGSGLTEI-CG--------------------
AGSKHSR--PT------------------------PLPDQRPSPNPEEIGEG-APCRYPR
EALHDPVFSRNPEGSRTLSTSRGK-ESRTLPCPQPCSSQPV-ATHAYSSHSSTLLCCRGG
DLGKEAFKAALRTVHPPCGVPSRAYEMDETGETSSRGPDVHLTRGL----EPKDVIREFS
ITESSTCEPSTVAAILSGAQGCRSPSA-SDVRRTSSFSHSATNGSLGLIGAPEEKVA---
---EKQAS--TELEAASFPAGMYSEPLRQFRDSSVGDQNAQVSQ-TSPEPP--ATTPGPH
ILDLSEGSVESKVVAE-PQHECFENT-TRCFLEKPQFSTELRDHNC-LDSQAKFVARLKH
TCSP--QED-SRWQEEEQHRDQAS-GGGEGFTQGMN-----PLPSNE-GGLDSCQILDAR
RQ-----------------EVAVAKPPVSKILSQGFKDPATVSLRQNETPQPVAQGPG-N
LYTGREQPAL-NHRGSLPVTAIFSGPEHS-KSSPTPQFSVVSSSHSLQELNLS-VEPPSP
TDEDT-QGPDRLWNPHLRGYSTGKAVA------RTSLQAEDSNQKASSHLD----DGTTD
HRPLKPATPPY---PVPSTLSH-------MPTP---DFMTSWMSGTLE--QAQQ-GKPEK
LGIQVRPENWCSQ-MDKGMLHFGSSDINPYALPWRTEEHAHISWKQYVFGSTVDVSCSQK
PQGLTPSNVARCSS--MDNGLEDQNSPFHCHLSTYANIRDLSTTHSSTENAQGSNEAWEV
FPGSSSIALGDPHILMSSEGVAPTSG-HDRRPQFRSPSGEAD-CLRSKPPL--AEGSTAG
PVDEIMLLYPSGAGCPVGQ-TRTNIFEQGTQTLD-SR-------CHQSSTDISFAQPEAS
AVSAS-DLASWTSMHSLSLHLSQLLHSTSELLGSLSQPGVARREQNTK--RDIPDKASQ-
-ALMMDGSTQTTVDEGSQTDLATP----------TLCLQ-ASETEPQGANV-ILEGLGS-
---DTSTMS----------QEEGDVPGVPQKREA-EETAQK-MAQ-----LLYLQ-----
-EESTPYKPQNPLTP-SSHLRFQKAPLR--QHLPSVGPSVSDAF-LPPSSQPEESSCIAV
SSPSP----SPCHSPGLLPNT-SEYPGDP--RVKKKL-GPTSALLVDRASSPILTLSAST
QELGL-PPGSLTLSAPSA----HPVEGHQKLD-SS---PDPVG----APRTPMDNYSQTT
DELGGS---QRG-------GSAL----QRS-----NGTSFLEVHSPHNPQQ---------
-----------SPKLQFSFLGQHPQQLQPRTTTGVQS-------------------RLQP
PPLRHR----SQRLADSFVPEEVTS-PEHGPLSGREP---SQWRSRTENGGESSASPGKP
Q-RTLDRPS-SCGG--L--------QHLSP--CPVSELTD-----------TAGL-RGSA
LGLPQACQPEGLLCS---SCQMCMAPEPQHHSLRDLPAHNKFSNWCGVQKGSPGGMDMTE
EELGASGDLSS-EKQ-EEGTPQP---------PNDHSQDPEWSQG------EQIPLQVGA
QNLSLSVELTEAKLHHGFGEADALLQVLHSGTGEALAADEPVISTWK--ELHARQ-----
----------KKAVETLRRERAERLGNFCRTRSLSPQKRLSLLPNKELFIWELDLPSRRR
EYLQQLRKDVVETTRSPESVSR-SAQPPSDIELMLQDYQQAHEEAKEEIARARDQLREQT
EQEKLRIHQQIISQL--L-----REEDKLHTLANSSSLCTS-SNGSLSSGMTSGYNSSPA
-LSGHLQSPENAG-Y------------------TNLPDS--RDVWIGDERGGLSAVR---
-------KNSAY-----GRRASLGS--CCCS--------PSSLSNSGTCF---SS-SYQD
LAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAV---------QLYYKVFS-
-STRHGFLG--AG

PF01852 // ENSGT00890000139327_7_Domain_2 (5654, 5806)

VVSQPLSHVWAAVSDPTLWPLYYKPIQTARLHQRVTNSISLVYLVCN
TTLCALKQPRDFCCVCVEAKE------GHLSVMAAQSVYDTSMPRPSRKMVRGEILPSAW
ILQPVTVEGKEVTRVIYLAQVELGAPGFPPQLLSSFIKQQPLVIARLASFLGS