Query Results 

MSAFPACGRND-SDVLGSPPLPRSSTPRVPAQSSRLQPHLKSDVSECENDDSLLRSASKI
RDINSTYVISACKKTGDRPLSPKPAGRLTLQRRVTR-NKEASSLCSEL-----GDSTEKT
AETRLTLQRRAKAESVGK----------------------WKTTQNVGGETGNNCAPREP
CTNV-KIVNNYKLSSVASSVPLAED--PKDVEMTADEKCKETFST-LSG-ANENAALKYL
SNRAP-IGSQSQV-VVRSGHS-AAKPLQSKSDSKVSGTGNLHHRSTGKDVAKTP-NKFES
LEK--------------------------------------------------RTPTKCI
T-EHRLTPKGGVFQLKSPAES-MLKHRMP--SLQVKHKP--KNSLL-ANKKEGSQENT--
----LPPEGETAVQN-AAPETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSQREKMDKASQVVFLNGDEI
A-VEHPDMKQVYTFSYDV---------SFWSFDDRHPDYASQTAVYEALAAPLLQR--AL
QGYNTCLFAYGQTGSGKSYTMMGLSE-EPGIIPRFCEDLFAQVTKK-QTQEISYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSLNVVSSYSDIQ-SWLELG
CKQRASAATGMNDKSSRSHSVLTLLMTRTKTESVEGEEHDHRITSRMNLVDLAGSERCAA
AHTCGERLKEGVSINK-SLLTLGKVISALSEQA-GRKSVFVPYRDSVLTWQYN---TILG
GNSKTTMIATVSPAASNI-EETL---STL-RYASKARMIINVARVNEDVNARLIRE--LK
AEIEKLKAAQRNSRTIDPEQYRLCRQEITSLRMKLYQQERDMAEM---QRMWREKLKQAE
KRKLQETEELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHKPNSSHD
IQLSGVLIADDHCTIKSFDGTVTIVPVGEAKTYVNGKRILEPTVLHHGDRVILGGDHYFR
LNHPVEVQKGPRPSGRD--ALTSEGPKDFEFAKNELLLAQRAQLEAEIKDARLKAKEEMM
QGIQIAKEMAQQELSSQKATYEGKIRALEAELKEESERKKMQEITNQKAHHKIEELEKAK
QLLEQEICINRKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQSQTNR
DKTFTIQLNWRSMKLSMLIQEANAISSKLNKCYVFARHDIADNGSGPDTS--VRVRNLRL
GISTFWSLEKFESKLAAMKELYESNPGNKS-EDVFCDPEDEWEPDITDAPVSSFSRR-RS
RSLMKNRRISGCLQDVQAHSMQNMHSSH--SSGLLEKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYNEEQTMADSLINNFLKIDDGLLAISKAHEEQDEDS---PCNLFSSDRATQS
FTIQVAGAFEQLVVLTTHWLSDSVSCT-STASLGDELRQEVKNLGGYLQLFLQGCCSDIS
SMVKEARKEVTQIVQGAVKSVGQLAALKGSQL-FMEGSLSKAAGVREEFVDAVCEGVGMG
VKTLLDSGLEKARELRQEV---LMQCAQDEATEQLSARAVRLIGSLENIFAEWRTKSFRT
HVQEESSGYQDLKEMLDLAPEFLKLKQCLEQTVEMVISALRGC--RGDVGLLR-RRLESL
CSLARGLRDDSRLC---AASAAGPESS--DPQADPRELESLASSLLFLFRS---------
------------------------------------------------------------
-----------

MSVYTASIQNP-SNALGISSSRNNSSVNIITKSSRLGQQLKTQISVCKNDNLLSQSIKKI
QDVNRTYVVSACKRIGDNPVTPKTDGRLTLQRRTVK-STESPFPGDQL-----ATEPEKT
RERPFTLRHRERTDSLEKCKINKSV----------------------GSGGK-NAISVAQ
QNYKEKVANADKDSYTRSTGPLVET--QRDLKVKPNPKSTESSSTP--KEENGTVSLKSL
TNKVS-TNLQNP-NEVRVGHLNAIKSIENTVEIQIPPRGTMNDRIPGEETVCTSDNKYGS
LER-------------------------------------------------SRTPRQWT
T-GQKISSKRTASRVNSPATSCLKSRASCLQVMTNKKGN--SNSLP-ANKSGILQHNN--
----PLDQEEMATQI-SRTEAGLVKVENSKVTVAA

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSNREKTEKASQVVFMNGQET
T-VQHPDMKQIYSFIYDF---------SFWSFDECHPNYASQMKIYEQLAVPLLER---F
EGYNTCLFAYGQTGSGKSYTMMGFGE-ERGIIPRFCEDLFARVAQQ-KTQEISYHLEMSF
FEVYNEKIHDLLVVKAENGQKKQPLRV-REHPVSGPYVEDLSVNVVSSSSDVQ-SWLELG
NKQRATAATGMNDKSSRSHSVVTLVMTQTKTEYVEEEEHDHRITSRINLIDLAGSERCTT
AQTSGERLKEGASINK-SLLTLGKVISALSDQVYNQKRVFIPYRDSVLTWLLK---ESLG
GNSKTTMIATISPAASNL-EETL---STL-RYAKQARLIVNIAKVNEDMNAKLIRDLELK
AEIEKLKAAQRSTQNIDPERYSRCRQEITSLRMKLHQQERDIAEM---QRAWKQKFEQAE
LRKVQETKELQKAGITFKMDNRLPNLVNLNEDPQLSEMLLYMIKEGQT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSNHD
IQLSGVLIADDHCVIKNFDGTVSITPLGEAKTYVNGKHISELTVLHHSDRVILGGDHYFR
FNHPVEVQKGKRSAYGT--VLPSDGAKDFEFAKNELLMAQRSE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPEQYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVKILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPRICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKKMANHAPEFLKLKHCLEKTIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSRIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSVHTIHNRNN-GIFLEVPSSQKSSSLSGVTHSSQLKLPLKSDMSECKKDDPLLRAACKI
RDLNSTYVISACKTTGDTSLTINPTSKLTLQRRATR-SKESSLLN-ES-----RDTTEKT
AETSLTLQRRAKTVSTEK----------------------WKTLQNVGNETESNCASQRT
RINV-KTVNNNPSSFVTSHTQIAED--SKDLALMGDQKYKETFSAL--SRANENTAVKHS
SSSSL-MGSQDQREAGRPGPL-ATKLIQSNLNVKVLGTENLH-PSVGKDTAKNS-SKFGS
LDK--------------------------------------------------RTPVKCT
T-EYKSTPKHDLPHLKSPGTS-ILKNRTP--RFQVKQRP--KNSF--SSKREISQKNA--
----LPIEEETAVQN-TSTETDLLKVENSQVTVAVRVRPFSKRYVICFKSKAKLVP----
---------------------------------------------CNVFLIPLLLE----
--------------------------------------------------------SIQV
SSIYNEKIHDLLVCKGENGQRKQPVRLK--------------------------------
-----------------------QFIIFTKTEI

PF00225 // ENSGT00890000139327_5_Domain_1 (694, 819)

VEGEEHDHTITSRINLVDLAGSERCSA
THTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRIFIPYRESVLTWQVS--FELLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_1_2 (819, 874)

IVNIARVNEDVNAKLIRE--LX
XXXXXLKAAQRNHPNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKQKFEQAE
KRKRQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIAEDHCTVKNFGGTVSIIPVAEAKTYVNGKHILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSSRD--TFISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELFSQKAAYESRIQALEAELKEESQRKKMQEINNQKANHKIEELEKTK
LHLEQEVYVNKKRLEMETLATKQALEDHSIRHAKILEALENEKQKIAKEVQILQQSRNNR
XKSFTIQSSWNSMKVSMMIQETS-----------------------------IRVRNLQL
GVSTFWSLEKFESKLAAMKEFYE----------------------ITNAPISSFSRR-RS
RSLMKNRRISDCLHDV-------------------HKSSTIYSTSAESFLPGICKELIGF
SVDSLGHSFDEEKTIADSLMNNLLKIYNGLLTISKAHEEQDEES---PDNCKQSH-----
------------------------------------CFTKIKKLGGYLQLFLQGCCSDIS
SMVKEAQKKAIHIIRQAVKYVGKLAVLKGNKLYFLESSNNKA--AKEEFIDAVWDGVGSG
MKILLDSGLEKAKGLQHDL---LRESAQNEVTEQMKANAIELIRFLENIFSEWKTKSFRT
QVQEDDSGYQDSKNITDLALKFLKLSHCLEKTIQISISALRGC--CSDVHLLK-NCVETI
CTLVNDVCSDFRES---STSVDHCENK--ISQVGHRELESLAKSLLLCFESEERPDLLKP
WESCNQDTGGEEEKEKSNSRWT--------------------------------------
-----------

MSVHTAHNRKN-SNILGSPSSEESSSLSALTHSSRLKLHLKSDMSECENDDPLLRSACKI
RDINSTYVISAGKKTGDTPLKSNPVSSLTLQRRATR-NKESSLLGGER-----GDTIEKT
AETCLTLQRRAKTDSAEKWKTTQMD-----------SFKKLKMTQNVGGETETNCASKET
SKNV-KIVSNDKNSFVASSLSSAKD--PKDFEMMADKKYKETFS-ALKG-ANENDSLRYS
SSRAP-IGSQSQIEVGRSEHL-ATKPIQSQLDIKVSGTGNLYHRSIGKDITKNS-SKFGS
LEK--------------------------------------------------RTPTKCI
T-EHKLTLKCGMPQFKSPTAS-ILKNRMS--NLQVKQRP--KSSLL-ANKRERSQENT--
----LPPEEDAAIQN-TSIVTDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTRREKIEKASQVVFMNGKEV
T-VEHPDMKQVYNFIYDI---------SFWSFDECHPHYASQTTVYEMLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-ERGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKSENGQRKQPLRV-REHPISGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLVDLAGSERCST
THTSGDRLKEGVSINK-SLLSLGKVISALSEQG-NQRRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKTAQKNNRNIDPERYRLYQQEIASLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQRERDMAEM---QRMWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLSEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TLGKYKPNSRHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGDAKTYINGKHILEPTVLHHGDRIILGGDHYFR
FNHPVEVQKGKGPSSKD--TLIIEGPKDFEFAKNELLLAQKSQLEAEIKEAQLRAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIRALEVELKEESQRKKMQEINNQKANHKIEELEKAK
HHLEQEIYINKKRLEMETLTTKQALEDHSIHHARILQALETEKQKIAREVQILQQNWSNR
DKTFTIQTNWNSMKLSMMIQEANAISSKLKIYYVFGRHDVS--GS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITNAPISSFSRR-RS
RSLMKNRRISDCLHDIQVHPIQNLHSSH--SSGVMEKPSTIYSNSGESFLPGICKELIGS
SLAFLIQSYDEENTIADSLMNNFSKIYKGLVAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQIACAFEQLVVLIKHWLNGLLPYT-STARLEDELKQEVKKLGGYLQLFLQGCCSDIS
SMVKEAHKKVIQSVQQAVKCVGQLAVLKGSKLHFLENSDDEAASIQEELMDAICDGVCLG
MNVLLDSGLEKAKELQHEL---LKQSTQNEVTKQIKANAMGLIRSLENIFAEWKIKGFRT
RVQEDNSGYRYSMKIVNLAPEFLKLKHCLEKTIQIIISSLRGC--NSDENL-S-NYVESI
CNLASDFHNGFSVS---PASVDNSENG--VPQSGHKELESVAKSLLLCFESEERPDLVKP
WETCNQNARE-EE-QQSKSSKTDCSKNKGVPKRVYELH--GSSPAASSEECTPSRI----
--QWV------

--MHSAHSRNH-SDSLCLPSSHKGSSLAALAHTSRLQLCLKSDVSECENDDPLLKSASKI
RDINSTYVISACKKTGDLPLTPNPKSRLTLQRRTPR-NKESSLLGSEP-----GVTAENT
VEPRLALQRRVNTHCVEKRGA-----------ANVDSAGRWGTTQDVGCETGNDRASEGT
DANV-NIVNNDKTSFVASSVQLAEG--LKDMEVMAEEKYKETLSVL--SGANENVALKCG
SESAP-CGSRGGTEVGRSGYL-AVKRTQSKLDVRVPGIGNFHHRSIGKDSAKNT-NKLGN
FEK--------------------------------------------------RTPVKCM
T-ERRLTPKCSALQHKSPAAS-TPKNRTP--NSLVQQRP--KSSLL-ANKRERSQENT--
----LPAEEEIAVQN-TSAETDLLKVESSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 696)

RVRPFSKREKSENASQVVFMNGEEI
T-VEHPDMKQVYTFVYDV---------SFWSFDEHHPHYASQTAVYETLASPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQIAKK-RTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVFGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX-----XX
XXXXXXXXXXXXXXXXXX-XXXX---XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXLK
AEIEKLKAAQRNIRNIDPERYRLCRQEITSLRMKLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLLNLNEDPQLSEMLVYMIKEGT

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGKYRADASHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGKRILEPTVLHHGDRVILGGDHYFR
FNHPVEVQIGKRTTGRD--TLTSEGPKDFEFAKNELLVAQRSQLEAEMKEEWLKAKEEMM
QEIQIAKEMAQQQLSSQKAAYEGKIKALEAELKEECQRKKMQEINNQKANHKIEELQEAK
QHLEQEVYLNRKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNK
DKSFMVQSSWSSMKLSMMIQEANAISNKLKKYYVFGXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX----XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXS
RSLMKNRRISGCLQDIQVHPIQNLSAH---SSGLMEKSSAIYSNSPESFLPGICKELIGS
SLEFLGQSYDEEKTIEDSDCL----TYNGLAVP--KPGEQDEXX---XXXXXXXXXXTQS
LTIRIACVFETLVLLLRHWLRDALPCA-GAARLDDELRQEVKKLGGYLQLFLQGCCSDIS
SM-KEAQKKVIQIIQQAVKYVGQLTVLKGSKLHFLEDSNHKVASDQEELVVAVCDGIGLG
MKILLDCGLEKAKELQQEL---SKECTQEEVTEQIKANAIGLIRSLEDIFAEWKMEHFRT
Q--EENSGYQDSKKIVILAPEFLKLNQCLEKAIQMIISTLRGC--HQDVSLLR-DCVEGI
CNVARGFHSDVCLP--SSTSVDSCQRG--PPQAGHRELESLAKSLLLCFEFEERPNLLKP
WETRNQNSRKEE--QQPRPGRTDCSRPKGVPKRVYELH--RPSPAGGADGCMPARI----
--QWV------

MSVYTAQRG-PSSGLPGAPASQRSSSPDGLGLGSSRKQLSSSDVSERENDDPFLRSARKL
RDINSTYVISACKAPGDAPLTPNPAGRLTLQRRVTR-NKESSLLGSEV-----GESSERK
TETRLKRTTA----------------------------KADSTTQSVGGAAASDGASRDT
SRKV-RIVSNKKNSPIASSAPSPED---GDTGLVADEKDRGTFSAL--RGANDSVTREYF
SHSTP-IRPQKEAEEARPGRL-ATKPFQSPLDVRASGTGSWHHRNLGEDVAKSR-NEFES
LGRGTPAKRTA-------------------------------------------------
--GHTWTPRRGTPQPQSAAMS-TLRPRTP--SSQGQQKP--KRSLF-ANKREGSHKHT--
----LPPTEEAAAQS-ASTERDPLKAENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 803)

RVRPFSKREKDEDAAQVVFLDGEEI
A-VRHPDLRQAYSFLYDV---------SFWSFDECHPRYAGQAAVYQTLAAPLLAR--AL
EGYNACLFAYGQTGSGKSYTMMGFGE-EPGIIPRFCEDLFAQVAKH-QTQEVRYHLEMSF
FEVYNEKIHDLLVGRGDGRQGKQALRV-REHPVSGPYVEALAVNAVGSYSDIQ-GWLQLG
SKQRATAATGMNDKSSRSHSVLTLLLTRTQTRSGDGNEQTTRDHC----ISLLAWRQQAP
GSGGLHWHQEGVSINK-SLLTLGKVISALAEHG-GRRRAFIPYRESVLTWQVS--FELSF
VELLPALWVVVAPEMGDRAVECL---SHSGSLCGGERYPSNRVGVKRVVVASEIRETEKT
-------ASRRWKHSCRPGEDRRGE-TTPHARHPCPRWARALCV---LERAWKEKFEQAE
QRKHHEIKELQKAGITFQVDNRLPNLVNLSEDPQLSETLLYVIREGT

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TAVGKRGPTSRPD
IQLSGALVADEHCTISHVDGTVSIAPVGEARTYVNGTHVLGPTVLHHGDRVVL

ENSGT00890000139327_5_Linker_3_4 (1014, 1176)

GGDHYFR
FNHPAEVRSGKRPPGGG--APASEGPKDFEFAKNEWLAAQRSHEFGGQRWG---------
------------------------------ELQG-EGSRRLQEMSNQEAHLRIEELERVK
QRLEQEVQANRRRLQLERLAAQQALEDHSVRHTRI

PF01271 // ENSGT00890000139327_5_Domain_4 (1176, 1196)

LEALEAEKQKIAQEVQALQQNQGSK
DRAPPVPTSWGSLKLSLMIQEANALSSRSQRQYVFGRHEAPDRGGGSGPR--VRVRNLRL
GVSTLWSLEKFESKLAALKELDESNCQS---EDLFCDPEDEWEPDLTDAPAASFSRR-RS
RSLVKNRRVSGYLHDIQAHAAPSLPSSR--SSGSGEKPGSLGSSSAASSLPGICRELIGS
SLAVLGRSGE-EETVADGLVDSLLRV-HGLLAISQAHAAQDEDS---PDDLFSADRAAQA
RAVQVACAFGQLAVLAPLWPGDAPPGP-HAARLAEELRQEVEKLGSYVQMFLQGCSSDIP
SMVTDAQSRATQAVRQAVACAGQLAVLSGSRLRLLDPGAYGGADAQEDLVDALWDGVGAG
VRLLIDSGLERAAELRREL---SGQHPQSEAAQQLRAKAEALIRCLETIFAEWRTESSRT
RAQGEPSGGGAPREMADRAPEMLNLTRCLEQTIEAVVSALRGR--RGDGGALR-TCVERV
CVLAGGGATD------------SCA-------QSRGDLTSAAKSLLLCFEAEDRPDLSEP
WDACPQNSRTGPA----------------AGRGVYALP---SRPPRSSGERAPSGT----
--QWV------

MSVHTSHSRHN-IGSLEVSSSQKISASSGLVHSSRLELHLKADMSECENHDPLVNAGSKT
IDINSTYVISACKKTRETPVTSDP-RRLTLQRRTACGNRESSLLGSEL-----GDTTRRT
ADTSLRLQRRH-D--------------------RADYVGKWETLNPVGGNPGSNSASQAS
RTE-AKGVNNDT--HVLSSVVSVKD--SNDTGL---TRCKDPGP--PVGASNEKVTVKDT
NSRAP-VGSQRQTEAMRSGHL-VVQPTESKSDTPVSGGRNSHRGNAGKDTAKQV-GTFGS
SDTRTPVKCVLEHRWTPRHDPPPPKSPALSTPKNNGKGIPKHGSTFRSASSESRTPVKCV
P-EHRWTPRHDLPPPKSPALS-TLKNRIA--SPRVKPRP--KSSLF-ANKRESSQEST--
----LPPEEESLVQK-TFTEPDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKTEKASQVVFTNGEEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPGYASQTTVYETLAAPLLDR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIVPRFCEDLFAQIAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEGLSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITSRINLVDLAGSERCST
AHSSGQRLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESTLTWLLK---ESLG
GNSKTAMIATVSPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRSNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEI---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

VT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHTPSSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFR
FNHPVEVQKGKKLSSRN-NLTTSEGPKDFEFAKNELLTAQRSRLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYERKIQALEAELREESQRKRLEELNNQKASHKIEELERAK
QHLEQEVYVNRRRLEMETLATKQALEDHRIRHARILEALEIEKQKIAEEVQMLQENRGNR
DKTFTIQPNWNSMKLSTMIQEANAISDKFKKCYIFGRHDASDKGR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNGGDRD-EDVFCDPADEWEPDITSTPVSSLSRR-RG
RSLMKNRRVSGCLHDI--HPIQSMQSSH--SSGLMEKPSTIYSNSSESFLPEICKELIGS
SIDFLGQSFDEEKTIADSLINNLLRLHNGVIAISKAHEEQDEES---QDNLFS-DRAAQA
LTIQVACAFEQLVVLFKHWLSDFLPCT-GSARLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVMEIIQQAVQCVGQLAVLKGSKLCVLENSNKV--SSTQEFMAALQDGVTSG
MKSLLDSGLETAQDLRQDL---SRQSAREEVTKQMKASTVEWVGSLENAVAEWRTKSFRT
QAQEGS--RQQVSKLLSLASEFLKLKSCLQQTVEMIVSALRGC--PSDLHCLR-SCTETI
CSLARKLHSDFSAL---SASAGSCGNE--LPRADCEELESLAKSLLLCFECEESPGLSKP
WESCSSNSKE----EQCKSDRADCGK--SEPRRACEPHGD-ATPAVSSGDCTPNRI----
--QWV------

MSVYTTHSRDH-DNILGIPPAPESSSLKVLTHGSRHKLHLKSDLSECEQDDPLLRSASKI
RDMNSTYVISARNKTGDVPLTPNPVGKLSLQRRVTR-NEESSVLHREL-----RDSTEKG
AETPLALHR-VRTDLVEK----------------------WKRERNTGG--ENNCASQET
GTNV-KTVKNDKSSFVTSFAPSSGD--SKDVRTMSTESHKETCSTF--CRANESVVLMCL
GGREP-AASQSQNEVAQSGRLT------AKPDAKVSGIGSLGHKSTGKDSAKNA-NKFGS
LEK--------------------------------------------------RTPTKCF
P-EHRLTQRHGLSQPKSPAAS-LLRNRMP--GLHEKQKP--R-SFL-VNKRERSQENT--
----LPPEEETAVHN-TSAEADPLKVENSQVTVAI

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKREKIENASQVVFMQGGEV
A-VEHPDMKQVYSFVYDL---------SFWSFDECHPHYASQTTVYKTLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTXXXXXX-XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXLRV-REHPVSGPYVESLSMNVVSSYADIQ-SWLGAR
NKQGATAATGXXXXXXXXXXXXXXXXXXXXTELVEGEEHDHRIMSRINLIDLAGSERSST
AQTSGDRLKEGVSINK-SLLTLGKVISALSDQA-NGKRVFIPYRESVLTWQHK---DVLG
GNSKTAM-ATISAAASSI-EETL---STL-RYASQARMIVNVAKVNEDMNAKLIRE--LK
AEIKL--KAAKNSRNIDPERYRLCXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX

PF00498 // ENSGT00890000139327_5_Domain_3 (974, 1014)

TIQNFNGAVSIIPVGEAKTYVNGKHILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPFSRD--AFTFEGPKDFEFARNELLVAQRSQLEAEIKEAQLKAKEEMT
QGIQIAKEMAQQELCSQKAAYESKIKALEAELKEESQKKKMQEINNQKANHKIEALEMAN
QRLEQEIHVNKKRLEMETLATKQALEDHSIRHARILEALEAEKQKIANEVQMLQQNQSCR
DKTFTIQANWSSMKLSMMIQEANAISNKFNKCYVFGRHDGSGRGNSSDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNNGNKS-EDVFCDPEDEWEPDITNASLSSFSRR-RS
RSLMKNRRISGCLNDVQAHSVQNLQSLH--SSGLMEKSSTLHSNSAESFLPGICKELICS
LLDSLGQNYDEEKTMADSLISSFLTIYNGLFAISKAYEDQDEES---QDTXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXVKKLGGYLQLFLQGCCSEIS
SMVKEAQMKVIEIVQQAAKCVGQLAVLTGSRLHFLESSAKAVQVQEEELMSAVYEGTNLG
MKSLLSSGLEKAKDLQQDL---LRQCTQNEVTQTMRTHAMRLMESLESMFAEWKTINFRT
QVKEESPGYQYLRKMTNLASKFLKLKHCLEQTIQMVTTVLRGS--HCDVSLVR-NRVESI
CSLARDFHDACGVH---PTAIDSCEKR--ISQADPGELESVAKLLLLCFESEERPGLLES
WETCNPNAREGQ--QHRNPSRPEASRSRGVPKRVYRLL--DSSPAVTSEACTPHRT----
--QWV------

MSVFTTHNRNN-SDILGIPPSPGSSSLNVLTHGSRPELHVMSDMTECEHDDPLLRSARKI
RDINSTYVISACKKTGDVPLTPNPVGRLALQRRVTR-NKESSLLGSEL-----GDSAENT
AETRLTLRRRAKTESV-----------EKRKTAQTDCGEKWKTTQNVGSAAENDGASLEA
STNA-RTVHKDKNPCIAPVVPLS-D--PKRIEMTADEKHKETFV-ALPG-ANEKVALKYL
SNRAP-TGSQGQTEAVPSGRL-ATKPLPSKVNIKVS--GNLPHRSIGKDTAKSA-NKFES
LEK-------------------------------------------------RRTPTKYI
A-GHRLTPKCDTSQLTSPAASSLLKKRVP--SLQATQKR--TSSLP-ANERERSRENT--
----LPLEEETAGQN-PPAETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKVEKASQVVFMNGEEI
A-VEHPDMKQVYNFIYDV---------AFWSFDESHPNYASQTTVYETLAIPLLER--AF
EGYNACLFAYGQTGSGKSYTMMGLSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKIESVEGEEHDHRITSRINLIDLAGSERCST
AQTSGERLKEGVSINK-SLLTLGKVISALSEQA-NRKRGFVPYRESVLTWLLK---ESLG
GNSKTAMIATVSPAASNI-EETL---STL-RYASQARM

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IINIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---HRAWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYGPNSSHD
IQLSGVLIADDHCIINNSDGIVSIIPVGEAKTYINGKHILESTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TLISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLRAKEEMI
QGIQIAKEMARQELSSQKAAYENKIKALEAELKEESQRKKMQEINNQKANDKIEELEKAK
QRLEQEIYVNKKRLEMETLAAKQALEDHSIRHARILEALETEKQKIAKEVQILQQNQSNR
DKTFLIQPNWSSMKLSMMIQEANAISNKFKKYYVFGRHDVSDKGSSLDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNSNNKS-EDIFCDPEDEWEPDITNAPVSSLSRR-RS
KSLMKNRRISGCLHDIQAYPIQNLHSSH--SSGLLEKSSTISPSSAESFLPGICKELIGS
SLDFLGQSYDEEKSMADSLINNFLKIYHGLFAISKAHEEQDEES---QDNLFSSDRATQS
LTIQVTCAFEQLVVLIKHWLDDILPCT-STARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQNKIIQIVQQAVKYVGQLAVLKGSELHFLENSSNKATGVQEDFMDALCDGVGLG
VKILLDSGLEKAKELQHGL---LRQCTQNEVTKQMKANAMGLIGSLENIFAEWKTKSFRS
KLQQENSGYQDLKKMVNLAPKFLKLKHYLEQTIQIIISALRGC--HSDKNLLK-NCVESL
CNLTKDFHDDFSIH---SASLDSCEKR--MPQGSHRGLEALVKSLLFCFESQESPNLLKP
WETCNQNTGE-EG-QQPKSSRTDSVRNKGVPKRVYELH--GSYPAVASEESTPSRI----
--QWV------

MSVYTAQ-SRNDSNILGIPSAPKSSSLPVLPHGSRLKQHSKSDMSERENDDPLLISASKT
RDINSTYVISACKKTEDTPLPPNPVGRLTLQRRVAR-SKEPSLLG-EL-----GDTTVKT
ADTCLALQRRAKPDAVEK----------------------WKAAQNVGGKGEDDCASPET
TINA-KAVNNDRNFLATPSVPLAAD--PKDPEVKAGGKYKETLSTV--GGADENVALKSL
SDRPP-AGSQSQTEAVRSGRL-ATKPIQSKLDIRVSGTGSLHHRSAGKDGAKLA-PKSES
LEK--------------------------------------------------RTPSKCV
T-EHRSTPKRGIPQFKSPATS-VLKNRMP--TLQVKQRP--KSSLL-ANKRERSRENI--
----FLLEEETALRR-TSTETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 770)

RVRPFSTREKSEETSQVVFLNGEEI
A-VEHPGMRQVYSFVYDL---------SFWSVDECHPRFASQTAVYEALAAPLLEQ--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEGLFAEIAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQTLRV-REHPASGPYVEGLSTNVVSSYSDIQ-XXXXXX
XKRKATAASGMNDKRFPSHSEFTLVMTQTKTEFVEGEELDHRIRSRINLVDLAGSERCSE
TQTSGERLKEGVSINK-SLLTLGKVISALSEQA-SGKRTFIPYRESVLTXXXX---XXXX
XXXXXXXXXXXXXXXXXXXXXXX----XX-XXXXXXXXXXXXXXXXXXXXXXXIRX--XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXMWKEKLEQAE
NRKLQVTKELQKAGITFQMDNHLPNLVNLNEDPQLSEILLYMIKEGT

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1007)

TTVGKYKPNSSRD
IQLSGVLIADEHCTINNFDGTVSIIPAGEAKTYVNGRLILEPTVLHHXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXLEAEIKEAQLKAKEEMM
QGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEECQRKKIQEINNQKANYKIEELEKAK
QRFEQEIYVNKKRLEMETLATKQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXQPSWSSMKLSVMIQEANTISNKLKKNYVFGRHV-SDKGSSSDTC--IQVRNLQL
GVSTLWSLEKFESKLAAMKELYESHCSNKC-EDVFCDPEDEWEPDITDVPVSSFSRR-RS
RTLMKNRRISSCLHGIAVPAAQDLHSSH--SSGLAGKSSPVYPDSAESFLPGVCKELIGS
SLELLGQSDDEENTVADNLISNFLKIHDGILAVSRAHEEQDEDS---QSNVFS-DRANQS
LAVQVASAFERLVVLTRHWLSGVPPRP-G-TGLRAELRREVRKLGGCLQLFLQGCSSDIS
SMVKEAQKQVIQIVHQAIKYAGQLAALSGDQLRSLESSDCGAASLQDDFMGAICDGVGLG
MESLLDSGLEKAKELR-AL---RKQSPQDEVTKQMKANAVGLIESLESLFAEWKTKSFRT
QVQEENSGYQDLKKMLNFAPEFLKLKHCLEQTIQIIISALR-------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINRTYVISASKKTADMPLTPNPVGRLALQRRTTR-NKESSLLVSEL-----EDTTEKT
AETRLTLQRRAKTDSAEKWKTAEID-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFVASSVPLDED--PQVIEMMADKKYKETFS-APNR-ANQNVALKYS
SNRPP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCSLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSLL-ANKQERSAENT--
----ILPEEQTVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRYCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNIVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTNGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRSVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLKMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAAGVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---FRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGC--HSDINLLQ-TCVESI
CNLANDFYSDFNVP---STSVGSYESR--VTHIVHQELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSSEECTPSRS----
--QWV------

MPIYTVPARSP-AGTRCTATFQKASSHNSLASSKASGQQLRSQVLG-EKDGLPSCPQNKA
EEINSTYVISACEKVNDVST-CKLEGRLTLQRRTGA-SKNSVSGSDTT-----QNTEELQ
TEKRLTLRRRVGTASTEGSTINHNIVPRKGNDN-FDARGKDK------------------
-ITLPHN--SKGTDGVKPNLKLSES--QSSTKLQHNLNSKDTFDLV--GGACENAINTCL
KDKTSTADTKFRNEVPKSEGFVTPKCTDSLSGEQQNEKGNIN-KLAGKQRVQHLMIKQSS
LEI-------------------------------------------------PRTPAKVL
AERF--TPKNSTSQNQPSLKP-VSNEQTPHLQISAKKLPSVSSSLP----VGTS------
--SGTKVSTETLAES-SSTGEDVFKVKNSKVIVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 818)

RVRPFSNREKTENSFPVIYMNGSET
I-VRNLSTNQVYNFSYDF---------SFWSFDKDHPNFASQAMIYKTLALPLLER--AF
EGYNACLFAYGQTGSGKSYTMMGFDE-DRGIIPRLCEDLFNQIAQM-DKEQVLYHLEMSF
FEVYNEKIHDLLVFKAENGQKKQQLRV-REHPVLGPYVEGLTVNVVRSYSDIQ-SWLELG
NKQRATAATVMNDKSSRSHSVFTLVMTQTKVEFVNEEKCDRRLTSHINLIDLAGSECCTK
AQTTGERLKEGVSINK-SLLTLGRVISALSKQSQNGKKTFIPYRESVLTWLLK---ESLG
GNSQTTMIATVSPAGSST-EETL---STL-RYAKQACSIINIAKVNEDVNVKLIRE--LK
AEIEKLKAAQKSALNTDREKYRRYLQEITSLRVELHQQERNMAEMQR-LRAWKEKLEQAE
KRKLEDIKELQKAGIAFKMDNRLPNLVNLNEDPQLSEVLLYMIKEGET

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGRCTQNSKHD
IQLSGVLIADDHCVIKNTVGQVSIIPLREAKTYVNGKCILDPTILHHGDRVILGGDHYFR
FNHPAEVQKVKTPSCGT--SCLHDGPKDFEFAKNELLIAQRAQLESEIEEARLKAKEEMM
QSVQIAKEMVQQELTAQKEAYESKIKSLEAEVREESRKKQIQELNNQKATTKIQELEKAK
KSLELELNFSKKRLEMETLATKQALEEHTIHHAKIVEALEAEKQKIAEEIHTLQKNHGSG
NKPVMIPLNWKSLKLSVMIKEANTISNALGKNTVFCRHDKIDDKTGSVSSVQVQVRNIKL
GITTFWSLEKFECKLAAMKELYESNDRNKAVVDVFYDPADEWEPDLSDSSISLLS-RRRS
RSFMKNKRISGCLSEIKLQSIQNKQTSY--ISDSLNK-PSICSSTSELFLPGICKETISS
ALDLLEQNHEGGKSIADSILTNLFIILSGASAISKAYEQQDEEC---QENFFSLDRAAQS
YSIRIVSAFDQIVVISKLWLNSIQKCP-GSRKVDEEMKQEIKNLGGYLQLLLQGCSSDIS
SMVTEAWSKVNQTVKQTMKYVGHMAVVTTTDISFPEENNIPALSLQ-EFVLAIYDGVGSG
LDCLIDAVQEKARKAQKEL---VKLCPQNEIQNRIKDNVVALARFLENNMPYCRKKETES
QLPED-SLYREIKKSTKIAVKYLELEQCLTEVCQIVSSMLQGL--YRNTSPLR-SSAENI
SVIAGYFNNYFSLFALSS--ANNPNQKMHVPFMNLDELDSLVDSLIMNFELEQGQPSLQS
QIIHNETTETRGG-QVETDQVEFAWKWNGIPECT------------QTPELSPGRI----
--EWV------

MSVHTSHSRHN-VGSLEVSSSQKISASSGLVHSSRLELHLKADMSECENHDPLVNAGSKT
IDINSTYVISACKKTRETPVTSDP-GRLTLQRRATCGNKESSLLGSEL-----GDTTRRT
ADTSLRLQRRH-D--------------------RADYVGKWETLDPVGGNPGSNSTSQAA
RTEAAKRVNNDT--RVLSSAVSVKD--SNDTGL---TRCKDPCP--T---SNEKVTVRDT
NSRAP-VGSQCQTEAMRSGHL-VVQQTESKSDTPVSGGRHSHRGNAGKDTAKQV-GTFGS
SDTRTPVKCVLEHRWTPRHDPPPPKSPALSTPKNNGKDIPKHGSTFRSASSESRTPVKCV
P-EHRWTPRHDLPPPKSPALS-TLKNRIA--SPRVKPRP--KSSLL-ANKRESAQEST--
----LPPEDKSIVQK-TFTEPDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKTEKASQVVFTNGEEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPGYASQTTVYETLAAPLLDR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQIAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEGLSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITSRINLIDLAGSERCST
AHSSGERLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESTLTWLLK---ESLG
GNSKTAMIATVSPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRSSRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEI---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

VT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHTPSSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFR
FNHPVEVQKGKKLSSRN-NLTTSEGPKDFEFAKNELLTAQSSRLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYERKIQALEAELREESQRKRLEELNNQKASHKIEELERAK
QHLEQEVYVNKRRLEMETLATKQALEDHRIRHARILEALEIEKQKIAEEVQMLQENRGNR
DKTFTIQPNWNSMKLSTMIQEANAISDKFKKCYIFGRHDASDKSR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESDGGNRG-EDVFCDPADEWEPDITSTPVSSLSRR-RS
RSLMKNRRVSGCLHDI--HPIQSMQSSH--SSGLMEKPSTIYSNSSESFLPGICKELIGS
SIDFLGQSFHEEKTIADSLINNLLRLHSGVIAISKAHEEQDEES---QDNLFS-DRAAQA
LTIQVACAFGQLVVLFKHWLGDFLPCT-GSARLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVMEIMQQAVQCVGQLAVLKGSKLCVLENSNKV--SSAQEFLAALQDGVTSG
MKSLLDSGLETAQDLRQDL---SRQSAQEEVTKQMKASTVEWVGSLENAVAEWRTKSFRT
QVQEGS--RQQISKLLSLASEFLKLKSCLQQTVEMIVSALRGC--PSDLHCLR-SCIKTI
CSLTRKLHSDFSAL---SASAGSSGNE--LPRADCEELESLAKSLLLCFECGESPGLSKP
WESCSSNSKE----EQCKSDRADCGK--SEPRHVCEPHGD-ATPAVSSGDCTHNRI----
--QWV------

MSIYTTYNKNN-SNILGIPSSQRSSPLNVLTHSSRRKLHLNSDMSKCENDDPLLKSASKI
RDINSTYVISACKETGDVPLTPNPTGRLALQRRVTR-NKESSLCGREL-----GDSTEKT
AETRLTLQRRAKTESVAKWKTARTESV--------------KTTQNVGSATEKDCASLEA
STNV-TIVNKDKNSFVASSVPLAKD--PKDIEMMADEKHKETFSKALPG-ASENVALKYL
RNSAP-TDSQSQTKVVPSGHL-ATKPLQSKLNTKVPGTGALHHGSIGKDMAKHS-NKFES
LEK---------------------------------------------------TPTKYI
V-GHKLTPRCGTPQLTSPAAS-ILKNRMP--SLQVK-KP--RSSVL-ANERERSQENI--
----LPLEEEITGQY-TSIETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREMVEKACQVVFMNGEEI
T-VEHPDMKQVYNFIYNI---------GFWSFDECHPNYASQTTVYETLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDIFAQVAKK-QTQEVSFHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVNSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTESVDGEEHDHRITSRINLIDLAGSERCST
AQTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---NTL-RYASQARMIVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRMKLHQQERDMTEM---QRAWKEKLEQAE
RRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGMT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFDGIVSIIPIGEAKTYINGKHILESTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGGD--TLTNEGPKDFEFAKNELLMAQRSQLEAEIKEAHLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELIEESQRKKMQEINNQKANDKIEELEKTK
QRLEQEIYVNKKRLEMETLAAKQALEDHSIRHARILEALETEKQKIAKEVQILLQNQNNR
EKTFLIQTNWNSMKLSMMIQEANAISNKFKKCYVFGRHDVSDKGSSSDIC--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNNSNKS-EDVFCDPEDEWEPDITNVPVSSFSRR-RS
RSLMKNRRISGCLYDIQAHPIQSLHSSH--SSGLMEKSSTIYSSSAESFLPGICKELIGS
SLDFLGQSYDEEKTMADSLINNFLKIYHGLFAISKAHEEQDEES---PDNLFSSDRAAQA
LTIQVTCAFEQLVVLIKHWLDDTLPCT-STARLEEELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKIIQTIQQAVKYVGQLAVLKGSKLHFLRNSSNKVASVQEDFMDALCDGVSLG
MKILLDSGLEKAKELQHEL---LRQCTQNEVTKQMKAKATELIGCLENMFAEWKTKSFRT
QLQQ-NSGYQDVKKMVNFAPEFLKLKHCLEQTIQIIISALRGC--HSDKNLLQ-NCVESL
CSLAKDFHDDLSMC---STSLDNCEKR--IPQVGHGGLESVVKSLLLCLESEERPDLLKS
WETCNQNTRE-EG-QQSKSSRTDSVRNKGVPKRVYELH--GSSPAGTSEESTPRRI----
--QWV------

MSVSMVYPRQD-SDLLGVPSSPKNSLGGGLSRSSSLKPPLKSEQAEGEGNDPLLRCASGS
REINSTYVISACEKAGGFPPGPQPVGRLTLQRRVTR-KAESSWLGSEL-----GDTFEKT
AEQRLTLQRRAHADPGEKWKAVE------------------------GGGTESHGASQET
GSSG-KAANPGGNALVASSVAFIED--SKSSALVTEEKRQETFSAP--REETGSAAPRYL
THGGP-AGSRSHIELVRAGPLATXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX
XXX--------------------------------------------------XXXXXXX
X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXLQVAQRP--QSSLL-ASKSERSQETT--
----LPPEAETTAQN-ACTEADPFKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKRERIEEASQAVFVNGEEV
V-VQHPSMKQVYNFMYDV---------AFWSFDECHPNYAGQAAVYETLALPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKQ-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGHTKQPLRV-REHPISGPYVEALSMNVVSSYSDIQ-SWLALG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXEGVSINK-SLLTLGKVISALSEQA-NRKRGFIPYRESVLTWQXX---XXLG
GNSKTAMIATVSPAASNL-EETL---STL-RYANQARLIVNVAKVNEDTNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITALRMKLHQQEKDMAEM---QRVWKEKFEQAE
KRKRQETKELQKAGITFQMDNHSPNLVNLNEDPQLSEMLLYMIKAGK

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGKYKPNSSHD
IQLSGVLIADDHCVINNFDGTVSIIPAGEAKTYVNGKHILEPTVLHHGDRVIL

ENSGT00890000139327_5_Linker_3_4 (1014, 1176)

GGDHYFR
FNHPMEVQKGKRPSSRD--TLISESPKDFEFAKNELLIAQRSQLEARIEAARLKAKEEXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEESQRKRVQEINNQKANYKIEELEKAK
QHLQQEIYVNKKRLEMETLATKQALEDHSIRHARI

PF01271 // ENSGT00890000139327_5_Domain_4 (1176, 1196)

LEALETEKQKIAREVQILQQNQSNR
DKTFTIQPNWSSLRLSMMIQEANAISHKLRKGYVFDXXXXXXXXXXXXXXXX---XXXXX
XXXXXXXXXXXXXXXXXXXXLYESNGSNRG-EDVFCDAGDEWEPDLTTASASSFSKR-RS
RSLMKNRRISGCLHDIQVHPTQSLHSSR--SSGLMEKPSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEEETTADTLTANLLKIYSGIAAIAQAHDRQDEDS---PES----------
----LACAFEQLVVLSRHWLSVAPPCT-RTARLGDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKVADIVQQAVRCVGQLVVLQGSQLRFLDNNHNEAVSLQEGFMDAVCDGVCLG
VKILLDSGLEKTKELQHEL---LKQCPENEVTTQMKANAMGLLRSLENFLAGWKTKDPSA
QAREKNHGCQEWTQLATFASEFLKLQRCSQQTVQLTISALRGS--HRDGHLLK-NCVESI
CNLTDKFQDYFSMP----------------PTSANRELASLAKSLLLCFESEERPALSKP
WKTCHQNAREQQQ---SK------PRHTGAPKRPCELP--GSSPAPASEEHTSRRS----
--QWV------

MSEHTVHNRNN-SKILGIPSSQKSSSLSTLTFKSRLKLHLESNMSECENDDPLLRSTSKN
KDINSTYVISART--------STPEGKLALQRRTTR-NKESSLLGSEL-----GDTIEKT
GEKCLTLQRRAKTDSSEKWKTTKTD-----------CVQKWKTVQDVGGKTENNCASKET
SANV-KVVNNDKNSFVASAVPLTKD--PQDIEMMADEKYKETFSAL--REANENVALKYS
STRAP-IGSQSPIEVVKSGHL-AAKPIQTKLDMKVLGAGNVHHRSIGKDTTKNS-NKFGS
LEK--------------------------------------------------RTPVKCI
I-EHKSISKCGMKEMKKEKKS-LNKSFKS--LMQS--AF--RSAVY-AGIFYLSLERA--
----VMVVEEGVMTTARGKEPPVYKLEGETIGIT--VTTTNSQKKLMIQTHI-IVGGMEK
GKEEKSYKKEIWKYILPLSSGTGVTGNIFWKPS---------KIMFAGLHFPHKTKELPC
LGRMLCLTSSQXLIHNVVSR

PF00225 // ENSGT00890000139327_5_Domain_0 (561, 819)

MMGFSE-EPGIIPRFCEDLFAQVVKK-QTQEVRYHLEMSF
FEVYNEKIHDLLVCKGVNGQRKQPVRL-KQSGLVGPYRSNIKSQIVYRDARVA-QWVRHR
--PHIPRVVGLNPALAKLHNCFIIPLKFT----TSGEFHLIKIFCKI-IFSTAGHERCST
AHSSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYASQARLIVNVAKVNEDTSAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLSQQEITSLRMKLHQQERDMAEM---QRAWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCSLKNFGGTVSITPVGEAKTYVNGKCIMEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSSRD--TLISEGPKDFEFAKNELLLAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAFESKIKALEAELKEESQRKKIQEINNEKANHKIEELEKAK
QHLEQEIYVNKKRLQMETLATKQALEDHHIRHARILEALETEKQKIAKEVEILQQNRNIR
DKTFTIQTNWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKGS-ADTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRS-EDVICDPEDEWEPDITSAPVSSFSRR-RS
KSLMKNRRISGCLHDIQIHPVQNLHSSL--DIGLLEKSSIIYSNSAESFLPGICKELIGS
SLDFLGQSYDEEKTIADSLMNNFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRATQL
LTVQIASAFEQLVVLIKHWLSDFLPCT-STAKLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQEKVIQIVQQAIKHVGQLAVLKESKLHFLENSNNKAASIQEELMGAICDGIGLG
MKILLDSGLEKTKELQHEL---LSQCTQNEVTKQMKANAMGLIRSLENIFAEWKIKSCRT
QMEEENSGYQDFKKMINLAPEFFKLKHCLEQTIQIIMSSLRGY--NNDVNLLK-NSVESI
CNLASDFHGDFSVP---CTPVDSCENK--VPPIGHRELESVAKSLLLYFESEERPNLLKP
WETCDQNPTEKE--QQSKPSRTDCSKKKGVPKRVYELH--GSSATVTSEGYTPCRI----
--QWV------

MSAHTIHNRSN-RDFLEVPSSQKSSSLSTLTHSSRFKFPLKSEMSEYEKGDSLLRSARTI
RDLNSTYVISACKTTGDMPLTINPTERLTLQRRATR-NKESSLLSSES-----RDTTEKT
AEASLTLQRRAKTVSVEKWKTAKAD-----------SVAKWKTRQDVGSETESNCASQRT
RTNV-KFVNNNKNSFVTSSTQIAED--SKDAMLMVDQKYKTFSA-P-S--GANENTLKHS
SSSTL-VGSQDQREAGGPGPL-AAKPIQSNLNIKVSGTGNLH-PSTGKDIAKNS-SKFGS
LDK--------------------------------------------------RNPVKCM
T-EYKSTPKHDLPQLKSSGTS-ILKNRTP--SLQVKQRP--KSSLL-SSKREISQKNT--
----LPIQ-ETEVQN-TSIETDFLKIENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKIEKASQVVFMNGEEI
I-VEHPDMKQVYSFIYDV---------SFWSFDQCHPHYASQVTVYETLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHFEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPFVEALSMNVISSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTETVEGEEHDHRIISRINLVDLAGSERCSA
AHTSEDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIARVNEDINAKLIRE--LK
AEIEKLKAAQRNNLNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKRQETKELQKAGITFQMDNRLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKNKPNSSHD
IQLSGVLIADDHCTVRNFGGTVSIIPVAEAKTYVNGKHILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSSRD--TFISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIQALEAELREESQRKKMQEISNQKASHKIEELEKTK
LHLEQEVYVNKKRLEMETLATKQALEDHSIRHAKILEALETEKQKIAKEVQLLQQSRNNR
GKTFTIQPSWSSMKVSMMIQEANTISSKLKKYYVFGRHDASVKGS-SETS--IRVRNLQL
GVSTFWSLEKFESKLAAMKELYESNGTNRG-EDVFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISDCLHDIQVHPMQNLCSSR--SSGLMEKPSTIYSTSAESFLPGICKELIGS
SMNFLGHSFDEEKTIADSLINNLLKIYNGLLVISKAHEEQDEES---QDNLFSSDRAVQS
CTVQIACSFEQLVVLIRHWLNDFLPCT-CIAKLEDELRQEMKKLGGYLQLFLQGCCSDIS
SMVKEAEKKVIQIIQRAVKYVGKLAVLKGNKLYFLEGSHNKAANVQEEFIDAICDGVGSG
MKILLDSSLEKAKELEYDL---LRECAQNEVTKQMKANAIELVRSLENIFSEWKTKSFRT
QVQEDDSGYQDSKKITDLALKLLKLKHCLEKAIQISISTLRGC--CSDVHLLK-NCVETI
CSLVSDICNDFSEL---STSVDHCENK--ISQVDHRELESLAKSLLLCFESEERPDLLKP
WESCNQDTGGGEEKEESNSGQTGCSRNKSVPKRVYELH--EACPAASSEVCTPSRV----
--QWV------

MSFYTAHTRNN-SDILGIPSSPKNSSLNVLTHSSSLKLHLKSDTSECENDDLLLRSASKI
KDINSTYVISACKRTGDIPPTPNPAERLALQRRATR-KKESSLLCSEM-----EDNIEKT
AETRLTLQRRTKTDSVEK----------------------WKRAQNVGGKTENNCASQES
SRNV-KIVKTDKNSFVVSSIPLAD---LKDNQMMADEKCKETFSTP--SGANENVDLKYL
SNRAL-IGSQSQNEVARTGHL-ATKPIQSKLDIKVIGTGNLHHRSIGKDIVKNSNNKFGS
LEK-------------------------------------------------ERTPIKCI
T-EHKSTPKFSMSQLRSPASL-VLRNRML--SLQVKQRP--KSSLL-ANKRERSQEKT--
----LNTEEETALQN-TFTETDPLKVENTQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RIRPFSKREKIEKASQVVFLDGEEI
T-VQHPGLKHVYNFIYDV---------SFWSFDECHPIYASQTTVYKTLALPLLER--AF
QGYNTCLFAYGQTGSGKSYTMMGLSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGHRKQPLRV-REHPISGPYVEALTMNVVSSFSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSIFTLVMTQTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLK---ESLG
GNSKTAMIATISPAASNI-DETL---STL-RYAQQARLIVNIAKVNEDVNAKLIRXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXXXXXXXXXXKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGKTTVGKYKPNSRHD
IQLSGVLIADDHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLEAEIEEARLKAKEEMM
QGIQIAKEMAQQELSSQKATYESKIKALEAELKEESQRKKIQELSNQKANYKIEELEKAK
QHLEQEVYVNKKRLEMETLATKQALEHHSMRHARILEALESEKQKIAKEVQILQQNRSNR
EKTFTIQPNWSSMKLSMMIQEANAISNKLRKYYVFGRHDVSDKGSSPETSVQVQVRNLQL
GISTFWSLEKFESKLAAMKELYESSGG-----------EDEWEPDITNTSVSSFSRR-RS
RSLMKNRRISGCLHHIQVHPIQNLHSSH-SLXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGCCSDIS
SMVKEAQNKVIQIVHQALKYVGQFAVLKGSKLHFLENNNNKAASLQEDFIDAICDGVGLG
MKLILDSGLEKTKELQHEL---QKQCTQNVVTKQMKANAMELIRYLENVFTEWKTKSFRT
QIQEENFRYQDSKMLVNLAPEFLKLKHCLEQIMQVIISILKGS--HSDVKLLK-NCVENI
CNLARDFHDYVNVP---SSFVNSYENR--KPLVDPRELESLAKSLLLCFETGER-----P
WETCNQNTKEEE---QCKSSRTEPSRNKGVPKRVYELH--GPSPAVSSEESTPART----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRKIDPEQYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVKILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYPNSAESFLPRICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKKMANHAPEFLKLKHCLEKTIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSRIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSMYNTTFIQNRNDAFGLS-SQNKSSLTALNQSSRLKQHMKSEIPECENDDSLSKSLNKI
KEVNRTYVISACKKVPEVSLTPNLEGKLALQRRTRK-IQEQPLLGSQL-----QEE---T
T-GKLTLQRRITTDTLEKCKTNKNV----------------------PNGVYNEKSGLQQ
SNKSVKTANTDKLSLGKSVSSVVED--IKQKNPPIDEKNNEKFSIP--RAENGNLLHDRS
SVFQA-VEPQSQNEVSRLGHSAGMKPMQNSSDVKITTTGNLSHRSVGKETTKNLNNKFGS
MEK-------------------------------------------------PRTPRQWI
MEESKFTPKSSIPQGRVTALS-IPKNRTCLQIVQKQKST--PSSFL-ENKRERSQENT--
----LLREE-T-TQN-TYRQSNLLKVENSQVIVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 817)

RVRPFSSREKTDNASQVVFMNGQET
T-VQHPDMKQNYNFVYDF---------SFWSFDKCHPNYASQSTVYETLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFGE-ELGIIPRFCEDLFSQIAKK-ETQEVSYHLEMSF
FEIYNEKIHDLLVCKAENGQKKQPLRI-REHPVSGPYVEALSVNVVSSYSDVQ-GWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEDEEHDHRIISRINLIDLAGSERCST
TRTSGERLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASSI-EETL---STL-RYAKQAGLIINIAKVNEDVNAKLIRE--LK
AEIEKLKATQRNTRNIDPERYRRCQQEITSLRMKLHQQEKEIAEM---HRAWREKLEQAE
KRKLQETKELQKAGITFKMDNRLPNLVNLNEDPQLSEMLLYMIKEGKT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSDHD
IQLSGVLIADDHCIIKNFDGTVSIIPLGDAKTYVNGKHISESTILHHGDRVILGGDHYFR
FNHPVEVQKGKISFCGS--LLTNDCPKDFEFAKNELLMAQRSQLEAEIEEARLKAKEEMM
QGIQIAKEMAQQELSSQRAAYENKIKALETELKEESERKKMQEINNQKANDKIQELEKAK
QHLEQKVHANKKRLEMETLATKQALEDHTVRHTKILEALEAEKQKIVKEVQILQQNRNNK
DKMLTIQPNWNFMKLSMMIQEANTISNKLRKCYVFYRHDISSEGNTIEPFVQVQIRNVQL
GISTFWSLEKFESKLAAMKELYENNSSVKS-EDIFYDPEDEWEPDLANTTVSSFSRRSRS
RSLMKNRRISGCLQDIKVHPVQNLNSTS-GGGGLMEKSDSIYSNSTESFLPGICKELIGS
ALDFLSQND-EEKTMEDSLITSFLKIHSCMIAISKAYEQQDEES---QDNFFSTDRATQL
FCIQMTSAFEQLVVLTKHWLNDFPQST---SIPDDDLTQEVKKLGGYLQLFLQGCCSDIS
SMVNEVQKKIIQTVLQGLRYVGQIAVLKGAKFHLSENNRDKMVNLQEDFINAICDGVRFG
LNTLLNSGLEKIRQLLHELELFRQQCSQNKVLEKMKTNAMALTRFFENTIADWKKKGFRA
QVKEEESVYQGAEKLINFATEFLKLKHCLEQISQIVISTLKGLGSSSDVILLK-NCVENI
CILAKHFNDNFSLFTSLSDSTSAHDDR--ISDVDFREIQSLAKSLLLDFESEEQLYLLKP
KEISKQNSKDEEK---YKLIRT------DEPKYDCKFQ--IPSSALCTEELSPNNI----
--EWV------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------SACKNS---QASLKTTRP--GSKFI-LQRRERSSKDE--
----IQPKGDTAFSN-FNLEEEHFKAENCAVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKREVNEKAVQVVFMNGQET
T-VQHPDSKQNYIFCYDF---------SFWSFEKSQPSFVGQASVYEKLAVPLLEW--SL
LGYNTCLFAYGQTGSGKSYTMMGFDG-EPGIIPRFCSDLFSRIQAT-MKQKLSFHLEISY
FEVYNEKIHDLLIFKAENGQKKQPLKV-REHPLTGPYVEDLSMNVVSSFQDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHDHRITSRINLVDLAGSERCST
AQTSGERLKEGVSINK-SLLTLGKVISALSENSQTRKKTFIPYRESVLTWLLK---ESLG
GNSKTSMIATISPAATNM-EETL---STL-RYAKQARLIINVAKVNEDLNAKIIRE--LK
AEIEKMKASQLSAKNKDSEKYRQCHQEVTSLKLKLCQQEREMSEL---RRAWKDKLEQAE
QRKKVEMQELQKAGITFKMDNRLPNLVNLNEDPQLSEMLLYMIKEGQ

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGKYKAGSSHD
IQLSGALIAEDHCIITNNENIVCIKPFGDAKTYVNGNQISGSTILHHGDRLIL

ENSGT00890000139327_5_Linker_3_4 (1014, 1174)

GGDHYFR
VNHPMEVNRLN------ATTQVSDGPKDYEFAKNELLSAQRSQLAEEIEEARLRAKEEMM
EGIQIAKEMAQQELTSQKFAYEEKIRDLEAQLKKESQHKELQEMNSQRATTRIQELEEMK
IHLQQEVQFNKKRLEMETLATKQALEDHNVRHA

PF01271 // ENSGT00890000139327_5_Domain_4 (1174, 1196)

KILQALEAEKQKIAKEVQMLQRERNSQ
DRAMAVQPTWNNMKLSVMIQEANSISSKLKKHTVFSRHDVTDKENLPTNPVQIQVKNLKL
GIVTYWSLEKFEYKLAAMKDLYENHGSTKD-DDVFYDPGDEWEPDLSNTSVSRFSRR--N
RSLMKNRRISGCLYEIRVHPIQSLQSGH--ASALHLGSSSVSSNPSDSHLPGICKDLIAS
SLDYLGRSHVDESNMADSMIDSVKRACIGVRTVSQAYEQQKEDS---TDMLFLANREAQS
HSVQLTSAFQQLVVLNKHWPRLLPEIQ-EMTKPADNVSLYIRKLGGYLQLLLQGCTSDIA
SMVTEARDKSFHIAEQILQNIGQLAALTNTELHFLEEELKDEKDLQKLFSRSVSEGLRFG
LQSIMESVLKATHDIYTHI---QRFIVQDEHLTEIKTNAIRLTTFLQKCLA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSASTAH-SRNDRDLLGVPS-TKTSSLSVLPQGSKLKLHPRSDSSECENDDPLLRSASKV
RDINSTYVISACKKTEDTRLLPNPVGRLTLQRRATR-SKEPSLLGRES-----GDAGAKT
AETRLALQRRTKTDYMGK----------------------WKGMQDLGGRTENSRPSPET
GISV-KAVSSDKDLPVAPSVPLTPD--PKDPEMKADGKCAATRSAL--SGVGENVALKSL
RERAP-AGSQSQTEAVRTPCV-AVRPTESRLETRESGAGASHHRGAEKEATKLP-RRFES
LEK--------------------------------------------------RTPFKCI
S-ELRSTPRRGVLQPPSPAAL-VLRSKRP--TLQVKQTP--QSSLL-ASQRERSRENT--
----FLLEEETALQK-TSAETGPLKVESSQVTVAVLPKP

PF00225 // ENSGT00890000139327_5_Domain_0 (460, 746)

FPEREKREGAPQAVFLDGEEI
A-VEHPGTRQVYSFAYDL---------CFWSVDERHPRFASQMAVYQALAAPLLGQ--AF
QGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAEIAKK-QTEEASYHLEMSF
FEVYNERIHDLLVCKGENGQRKQTLRV-REHPASGPYIEGLSTNVVSSYSDIQ-VWLELG
NKQKATAATSMNDKSSRSHSVLTLVMTQAKTEFVEGQELDHRIRSRINLVDLAGSERCSA
TGTSGERLKAGIVRVNDGSVCLYYVLIATSKLLREHLKLIFPSQIRLLHMLVT---EN--
----KACVYDVHPSFSALASRGFEPSWWL-QNFTKDRIVTHVLKSPHRLLFHKCLE--LK
AEIEKLKAAQRSSQNIDPERYRLCRQEITSLRMKLHQQERHMADM---QS--EEKLEQAE
KRRLQVTEELQKVGIAFRMDDHLPNLVNLSEDPQLSEILSYMIKEGTTT

PF00498 // ENSGT00890000139327_5_Domain_3 (950, 1014)

VGKCRPGSSHD
IQLSGVLIADDHCTITNSDGTVSIIPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFR
FNHPVEVQKREQPPSRE--NPVSKGPEDFESARNDLLMAQRLQLEAEIKEAEVRAKEEMM
QGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNEKANHKIEELEKAK
QRFEQEIHVNRKRLEMEALAAKQALEDHRIRHAKILEALETEKQRIAQEVQILQQNQSHR
DKAFAAQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSSDAC--IRVRNLQL
GVSTVWSLEKFESKLAAMKELYESRGSSRG-EDVFCGPEDEWEPDITHVPVSSFSRR-RS
RSLLNNRRVSGCLHGVEAHAGRDLRSSGCADTGLVGKSSPVYLDSAEPFLPGICKELIGS
SLELLGQSDDEEGTVADSLMSSFLRIHDGVLAVSRAHEEQDEDS---QCSLFT-DRANQS
LAVQVTSAFEQLAVLTGPWVSGVLLEA-GRAALLAELRQEVRTLGSRLQLFLQGCSSDIS
PMVKEAQKQVIQTVCRAVACVGRSVALTGGRLHLLESGAHGAPGLQDDFVGAVCDGVDMG
VRSLLDAGIEKAEELEREL---GRQSPQDEVTKQMKANALGLIESLGNLFAEWKTKSFRT
QVQEENSKYKDLKMMINLAQEFFKLKCGLEQTIQIIISALRGH--RGDVALLQ-DCVQRL
CSSARGLHGDRAGCP---------EDS--RAQASRRELESRATSLLLGFEFEEGPVLWGP
WEACDQGPRAAEQ-EQPRSDRPGPQRTRGVPKRVYELP--GPALGGSEQGVLPTRESAGE
GSPPAREQ---

MSVHTAPNRYN-SNILGITSTPKSSSLSALTHSSRLKLRLKSDMSECENDDPLLRSASKT
RDINSTYVISASKKTEDVSLTPNPVGKLVLQRRTTR-NKEPSLLGSEL-----GDTTEKT
AEKCLTLQRRAKTESSEKWKTAKTD-----------YMEKWKTMQDVGGERENNCASKET
TTNV-NTVNNVKNSFVASPVPLAKD--PKDTEMVADEKYKETFS-ATSG-ANENVTLKYS
SNRVP-AGSQSQTEVVKSGHL-AAKPIQSKLDVKVLGIGNLHQRNIGKDIAKNS-NKFGS
LEK---------------------------------------------------TPTKCI
T-EHKLTPKCGMPQLKSPAAS-GLKNRVP--NLQVKQRP--KSSLL-VNKRESSQENT--
----LPAVEQTAVQN-TCKETDPLKIENSRVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMNEEEI
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYETLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QSQEASYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPISGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSM
AGTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYASQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRIWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCSIKNFGGTVSIIPVGEAKTYINGQCILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--ILISEGPKDFEFAKNELLMAQRSQLEAEISQAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELKEESQRKKMQEINNQKANHKIEELEKAK
KHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVEILQQNRSNR
DKTFTIQTNWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKGS-SDTS--IRIRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNKS-EDVFCDPEDEWEPDITNAPVSSYSRR-RS
RSLMKNRRISGCLHDIQVYPIQNLHSSR--ASGVMEKSSTIYSNSAESFLPAICKELIGS
SLDFLGQSYDEEKTIADSLMNNFLKICDALFAISKAHEEQDEES---QDNLFSSDRATQS
LSIQIACAFEQLVVLIKHWLNDLLPCT-RIAKLEDELREEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKVIQTVQQAVKYVGQLAVLKGSKLHFLENSDNKAASVQEEFTDAVCDGVGLG
MKILLDSGLEKAKELQREL---LRQSTQNE-------------------------KSFRT
QVQEENPRYQDFKKMINLAPEFLKLKHCLEQTIQIIISSLR-------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

----MAALDGNSSDILGVPA-----SWSALAHGSRFKLPLKSQPFQCENGDPLLRSASKA
KDTHSSYVISACKKTGDAPVTPSPVGRLTLQRRATR-NKESSLLGSEL-----GDTAEQA
GGRRLTLQRRAKAESVEQ----------------------WKRTQSVRREAENVCAPEGA
RTSV-KRANNDPSAFVASSGPSAKD--LKDTAVAAAERCREPCPAP--SGASDGSSQKHL
GSGAP-AGPRGQTEVGRVGHL-AAKPVQSKSDSRVSGTGSLYHGGIGKHVAKNP-NQFGS
LDR--------------------------------------------------KTPTKFS
A-EHNVTAKGSVSQPKSPAAS-VLKNRTQ--SLHLKQRP--KSPPP-EGRRDRAPEET--
----LPPEEERAILN-ASVEADTCKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKIEKASQVVFMNGEEI
I-VEYPDMKQTYTFTYSV---------SFWSFDECHPRYASQTAVYETLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPASGPYVEALSMNVVRSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHEHRITSRINLIDLAGSERSST
AHTSGERLKEGVSINK-SLLTLGKVISALSEQA-NRKKVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYASQARLIVNIAKINEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRFCRQEITSLRMKLHQQERDMAEM---QRAWKEKFEQAE
KRKHQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKSDSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYINGKHILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKEKRPPGRD--TLTSEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIRALEAELKEESQRKKLQELHTQQATDRIAELERTK
QRLEQEVHVRSRRLEMEALAAKQALEDHSIRHTRILEALEAEKQKIAKEVQILQQNRSNR
DKTFTIQPNWSSMKLSMMIQEANAISSKFRKCYVFGRHDVSEKGH-SHTS--VRVQNLQL
GISTFWSLDKFESKLAAMKELYESNGDNKD-EDIFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRVSGCLHDMQVHPARNLHSPR--SSGLMEKSCTIYSKSAESFLPGICKELIGS
SLDSLGRSYDEEKTLADSLMDSFLTIYSGLFSISKAHEEQDEES---QENLFASDRAAQS
HSLQIACAFEQLVVLIKHWVSDFLPGT-RIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKETQEKMIQIVHQAIKYVGQLTVLKGSKLYFLENSDDKAASVQEEFVDAVCDGVGLG
MKVLLDSGWEKAKELRHEL---LRQCSPIEATKQMKVNAIELIRSLEDIFAEWKKESFGT
QVQEKDSGHQDSKEMINLAPEVLKLIHCVEKTVQIIISALKGC--HDDVNLLR-SCVGSI
CRLAREVHEGFSVR---SSSVDCRGGR--VPPGGLRELESRAESLLLCLGSEEGASVLTP
WESCDQNTREERQPLQSKPRRADCGRRRGAPTRVCELP--ALAPSVGSEECLPRRI----
--QWV------

-----VSIRKT-YKARRSTASQKIASQNASASSEMLGQQLASQVSGKDQDSLLSCSQNKS
EEVNRTYVISACKNVDDTSLTLKPQDRLTLQRRTRT-SKNLALSSEQSDKNIPQGTENKQ
MEKKLTLQRRVKSGSVEKSTINGNTVSGTENSV-FDAEGKYK------------------
-IAFQRGISNNDTHYIKSSCKLAEG--QQVTKLSYKSNSKDLFGNI------ENDGSLHS
KCRMSAAVAKL-EKVPISEQIATSEYVNQISGEQLNEQGDLR-RIAGKTRLQQL--KHNS
LER-------------------------------------------------PRTPTKAW
TEEFKLTPKNSTFQIKSSLSA-SSKQTANLPTVSEKK----TSSPP----VGIS------
--AKADENAETLAES-NSTVRDIFKVENSKVVVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSSREKNENLLPVVSMSGSET
A-VRNPSTNQLYSFSYDF---------SFWSFDKCHPNFASQEMIYKTLALPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFDE-DRGIIPRLCEDLFTRIAQM-DQQQVLYHLEMSY
FEVYNEKIHDLLVFNAESRQKKQPLRV-REHPVLGPYVEDLTVNVVSSYSDIQ-SWLELG
NKQRATAATVMNDKSSRSHSVFTLVMTQTKVKFVDEEQRDHRLTSHVNLIDLAGSECCST
AQTTGERLKEGVSINK-SLLTLGKVISALSKLSRNGKKTFIPYRESVLTWLLK---ESLG
GNSQTAMIATISPAASST-EETL---STL-RYAKQACSIINMAKVNEDVNAKLIRE--LR
AEIEKLKAAQKSAQNRDPEKYRHYLQEITSLRIKLHQQERDMTEMQSMLRAWKAKLEQAE
KRKLEDIKELQKAGIAFKMDNRLPNLVNLNEDPQLSEVLLYMIKEGE

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGRYTADSKHD
IQLSGVLIADDHCVIKNTTGQVSIIPLREAKTYVNGNCIVNPTVLHHGDRVILGGDHYFR
FNHPVEVQKIKGLSCGT--TLLHDGPKDFEFAKNELLIAQRAQLESEIEEARLKAKEEMM
KSVQIAKEMVQQELTSQKEAYESKIKSLEAEVREESHKKEVQELNNQKAASKIQELEKAK
QNLELELQFNKKRLEMETLATKQALEDHTIHHAKILKALEDEKQKIAEEIQTLQKNRASG
NKTVNTPLSWNSLKLSVMIKEANTISSELGKNTIFNRHEKTDDKTGSVSSVQVQVRNIKL
RIATFWSLEKFECKLAAMKELYESNDSNKA-ADVFYDPADEWEPDLSDASVSSLS-GRRS
RSFMKNKRISGCLSGIKLQPIQNTQASY--ISGAQNK-SSICPNFFDSLLPGICKESISS
ALDLLEQNHEGGKSIADHLLINLFTISSGVSAISKAYELKINVISELPFTITYLDLDAQS
YGIKITSAFDQLVVLIKTWLNDVQKCI-GSMKINEEIKQEVKNLGGYLQLLLQGCSSDIS
SMVTEAQSKVNEAVKQTMKCIGHLAVFTRTDISFFEENTISTISLQKDFVRAVYDGVGSG
LVLLTDTVQEKARMMQKEL---VKQYPQNEIQSQIKDNAVALARFLESNVSHCRKKGIQS
HLPEEEWLYQEIKRSTNIAAKYLELERCLSEVHQIVSSTLQGS--FRNTSLLR-SFAGEI
SIIAGYFNNYFSLLALSSASANNPFQRTTMPFMNLDELDSLVDSLILSFELEQGQLKPRS
HVACNETTETEGK-RVETSEAELSWKQKGVPKHTYKLQ----SPPALSGELSPDRV----
-IEWV------

MSVHTSHSRHN-IGSLEVSSSQKISASSGLVHSSRLELRLKSDMSECENHDPLANAGTKT
IDINSTYVISACKKARETPATPDP-GRLTLQRRTTW-NKESSLLGSES-----GHPTGRT
ADTSLRLQRRPLA--------------------RADYGEKWETSNPVGGNPGSKSASQKG
RTE-AKLVNNDS--CALSSVVSEKD--SNDTGL---TKRKDPCP--ALSTSNEKVTVKNP
NSRAP-IGSQRQTEAMRSGHL-VVQPVENKADIQVSGGGNSHHGNAGKGIAKHT-STFGS
SETRTPAKCVSEHRSAPRHDLPPPKSPALSTQKNNGKDIAKHVSTFRNSSSETQTPAKCV
L-EHRWAPRHGLPPPKSPALS-TLKNRIA--SPRVKPRP--KSSLL-ANK--SSQEST--
----LPPEEKSTVQN-TFTEPDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKTEKASQVVFRNGEEI
T-VEHPDMKQIYSFIYDV---------AFWSFDECHPGYANQTTVYETLAAPLLDR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQIAKK-QASEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRSEGEHPVSGAYVEGR-VNVSAPLSQQE-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHSSGERLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESTLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 878)

IVNVAKVNEDMNAKLIRV--LR
TRASLGKPSCSFTPNFLPKEYTLVGKEISYPRGELPQ

PF16183 // ENSGT00890000139327_5_Domain_2 (878, 947)

QERTWQKI---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

IT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHTPNSSHD
IQLSGVLIADDHCTIRSYGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVVLGGDHYFR
FNHPVEVQKGKKTSRN---NLTSEGPKDFEFAKNELLAAQRSRLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQRAAYENKIRALEAELREESQRKRLEEINNQKASHKIEELEKAK
QHLEQEVYVNKRRLEMETLATKQALEDHRIRHARILEALEREKQKIAEEVQILQENRGNR
NKTFTIQPNWSSMKLSTMIQEANAISDKFKKHYVFGRHDASDKGR-SDPS--CELQGSQV
GVNTAWSIEQFRLFLAVMIQLYESNSGTRG-EDVFCDPEDEWEPDITSTPVSSLSRR-RS
RSLMKNRRVSGCLHDI--HPIQSMHPSH--TSGLMEKPSTIYSNSSESFLPGICKELIGS
SIDFLGQSFDEEKTIADSLINNLLKLYNGVIAISKAHEEQDEES---QDNVFS-DRAAQA
LTIQVACAFEQLVVLFKHWLDDFPPCS-GSARLEEELRQDIKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVTEIIQQAVGHVAQLAVLKGSKLCVLEDSNKV--SSAQELMAALQDGTASG
MRSLLDSGLETAQELRQDV---SRQSAPEEVTRQMKANAVELVGSLENIFAEWRTKSFRT
QVEEGS--RQQGSKVLNLASEFLKLKSCLQQTIEMVVSALRGC--PSDLRCLR-SCTETI
CGLAHKLHGGFSAL---SDSAGSCGNE--QPRAVWEELESLAKSLLLCFEHGERPSFLKP
WESCTSNSTE----EQRESDRADCSR--SVPGRACEPHRD-PTPAESSGDGTPSRI----
--QWV------

MSLHTTYNRNNSGDILDIPSSQNSSSLNTLTHNSRLKLHLKSDMSECENDDPLLRSAGRV
RDINSTYVISASKKTGDMPLTPNPVGRLSLRRRTTR-NKESSLLASEL-----EDTTEKT
AETCLTLQRRAKTDSAEKWKTAETD-----------SVNKWQMTPNVGGKAENNCVSKES
RTNV-KIVNNAKNVFVASSVPLDED--SKVIEIMANKKYKETFS-APSR-AKENVALKYS
SNRAP-IASLSQTEVVRSGHL-ATKPTQSKLDIK--GTGNLYQRSIGTEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCI
T-EHKLTPKCNTPQLKSPAPS-MLKNRIS--NLQVNQRP--KSSLL-ANKQERSAENT--
----VLPEEETADQN-TSADKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTNREKIEKASQVVFMNGKEL
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPDYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVTYHIEMSF
FEVYNEKIHDLLVCKGESGQKKQPLRV-REHPVYGPYVEALS------------IWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSV
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNVDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYINGKCILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGRSPSGRD--TLISEGPKDFEFAKNELLIAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYENKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTTQTIWSSMKLSMMIQEANAISSKLKAYYVFGRHDVSDKSS-SGTS--IRVRNLKL
GISTFWSLEKFEYKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAAVSSLSRR-RS
RSLMKNGRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSSIYTNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKISNGLLAISKAHEEEDEES---QDNLFSSDRATQA
LTIQTACAFEQLVVLMRHWLNDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCLDIS
SMIKEAQKNAIHTVQQAVKYVGQLAVLKGSKLHFLENSNNKAGSVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTSAMGLIRSLENIFAELKIKSFRR
QVQEENFGYQDFKKMANCAPEFLKLKHCLEKTIEVVISALKGC--SGDVNLLQ-DCVESI
CNLASDFYRDLSVP---STSVESYEGR--VTHVVHKELESLAKSLLFCFESEDRPDLLKP
WETYNQNTEE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSAPAVGSEECTPSRI----
--QWV------

MSVHTIHNRNN-SDCLKVPSLQKSSSLSGLTDSSQFKLPLKSDMSEYEKDDPLLRSACKI
RDLNSTYVISACKTTGDTPLTTNPMGRLTLQRRATR-NKESSLLSSKT-----TDTTEKT
AETSLTLQRRAKPVSVEKWKTAKAD-----------SVEKWKTRQNVGSETESNCASQRT
RTNV-KIVNNNKNSFVASSIQIAEN--SKDIAFMVDQKYKETFS-PLRG-GNENVALKHS
SSSTP-MGSQDRSEAVGPGPL-AMKPVQSNLNIKVSVTGNLH-PSIGKDIAKNS-SKFGN
LEK--------------------------------------------------RTPMKCM
T-EHISTPKHDLPHLKSPGTS-ILKNRTP--SLQVKQRP--KSSLL-ASKREISQKNE--
----LLIEEETAVQN-TSTETDPLKVENSHVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKIEKASQVVFMNGEEI
T-VEHPDMKQVYTFIYNV---------SFWSFDECHPHYASQMTVYETLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QTEEVSYHFEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPFVEALSMNVISSYSDIQ-SWLQLG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEIVEGEEHDHRITSRINLVDLAGSERCSA
SHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIARVNEDMNAKLIRE--LK
AEIEKLKAAQRNNLNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTVKNFGGTVSIIPVGEAKTFVNGKHILEPTVLHHGDRVILGGDHYFR
FNHPAEVQKGKRPSSRD--TLINEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKSAYESKIRALEAELREESQRKKMQEINNQKANDKIEELEKTK
LHLEQEVCVNKKRLEMETLATKQALEDHRIRHAKILEALEAEKQKIAKEVQILQQNRSNR
DKTFTIQPNWSSMKVSMMIQEANAISGKLKKHYVFGRHDASDKGS-SETS--IRVRNLQL
GVSTFWSLEKFEYKLAAMKELYENNGSNKG-DDIFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISDCLHDIQVHQIHNLSSSH--SSGLMEKSSTIYSTSAESFLPGICKELIGS
SVDFLRYSFDEEKTIADSLMSKLLKIYNGLLVISKAHEEQDEES---QDNLFSSDRAVQS
LTIQIACAFEQLVVLIKHWVNDFLPST-SIAKLEDELRQEVKELGSYLQLFLQGCCSDIP
SMVKEAQKKVIQSIQQAVKYVGKLAVLKGNKLYFLENSNNKAASGQEEFMDVICDSVGSG
MKILLDSGLEKTKELQQDL---LRHCAQNEVTKQMKANAMGLIKSLENIFSEWKTKSFRT
QVQEDDSGYQDSKKITDLALKFLNLNHCLEKIMQIIISALTGC--YSDVHLLK-NCVETI
CSLVSDLCSDFSEP---STSFDCCEKK--ISQVGHRELESLAKSLLLCFESEERLDLFKS
WESYNQDTRG-EEKEESNSSWPGCSRNKGVPKRVYELR--EASPAVSSGVCTPSRI----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSGMSECENDDPLLRSAGKV
RDINSTYVISASEKTANMPLTPNPVGRLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLALQRCAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKER
RTNV-RIVNNAKNSFVASCVPLDED--PQVIEMMADKKYKETFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TMKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHFASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVAGK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALS------------IWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKHILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELQKAK
QHLEQEIYVNKKRLEMEALATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISR---------------------------------
-----------------FNLFFLSNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIL
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNE-------------------------KSFRR
QVKEENFEYQDFKKMANRAPEFLKLKHCLEKAIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTEE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSFPAVSPEECTPSRI----
--QWV------

MSLNTTYNRNNSGDILAIPSSQNSSSLNTLTHGSRLKLHLKSDVSECENDDLLLRSAGKV
RDINSTYVISASKKAGDMPLTPNPVGRLSLRRRTTR-NKESSLLASEF-----KDTTEKT
AETCLILQRCANTASAEKWKTAETD-----------SVKKWQVTPNVGGKIESNCVSKES
RTNV-KTVNNAKNSFVTSSVPLDED--SKVIEIMANKKYKETFS-APSR-AKENVVLKYS
SNRAP-TASLNQTEVVRSGHL-ATKPTQSKLDIKVSGTGNLYHRSIGKEIAKAS-NKFGS
LEK--------------------------------------------------RTPTKCI
T-EHKLTPKCSTPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSLL-ANKQERSAENT--
----ILPEEETAGQN-TSADKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFTKREKIEKASQVVFVNGKEL
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRIMSRINLIDLAGSERCSA
AHTNGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDTNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNNLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPDSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYINGKHILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGRRPSGRD--TFISEGSKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKIQEINNQKANHKIEELEKAK
QHLEQEIYFNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDASDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EYVFCDPEDEWEPDITDAAVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLLAISKAHEEQDEES---QDNLFSSDRATQA
LTIQTACAFERLVVLMKHWLSDLLPCT-NIAGLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENSNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTSAMGLIRSLENIFAELKIKSFRR
QVQEEHFGHQDFKKMVNRAPEFLKLKHCLEKTIEVVISALKGC--SGDVNLLQ-NCVESI
CNLASDFYRDLSVP---STSVDSYEGR--VTHVVHKELESLAKSLLFCFESEDRPDLLKP
WETYNQNTGE-EH-QQSKSSGIDGSKNKGVPKHVYELH--GSSPALSSEECTPRRI----
--EWV------

MSVHTIHNRNN-SDCLKVPSLQKSSSLSGLTDSSQFKLPLKSDMSEYEKDDPLLRSACKI
RDLNSTYVISACKTTGDTPLTTNPMGRLTLQRRATR-NKESSLLSSKT-----TDTTEKT
AETSLTLQRRAKPVSVEKWKTAKAD-----------SVEKWKTRQNVGSETESNCASQRT
RTNV-KIVNNNKNSFVASSIQIAEN--SKDIAFMVDQKYKETFS-PLRG-GNENVALKHS
SSSTP-MGSQDRSEAVGPGPL-AMKPVQSNLNIKVSVTGNLH-PSIGKDIAKNS-SKFGN
LEK--------------------------------------------------RTPMKCM
T-EHISTPKHDLPHLKSPGTS-ILKNRTP--SLQVKQRP--KSSLL-ASKREISQKNE--
----LLIEEETAVQN-TSTETDPLKVENSHVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKIEKASQVVFMNGEEI
T-VEHPDMKQVYTFIYNV---------SFWSFDECHPHYASQMTVYETLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QTEEVSYHFEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPFVEALSMNVISSYSDIQ-SWLQLG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEIVEGEEHDHRITSRINLVDLAGSERCSA
SHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIARVNEDMNAKLIRE--LK
AEIEKLKAAQRNNLNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTVKNFGGTVSIIPVGEAKTFVNGKHILEPTVLHHGDRVILGGDHYFR
FNHPAEVQKGKRPSSRD--TLINEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKSAYESKIRALEAELREESQRKKMQEINNQKANDKIEELEKTK
LHLEQEVCVNKKRLEMETLATKQALEDHRIRHAKILEALEAEKQKIAKEVQILQQNRSNR
DKTFTIQPNWSSMKVSMMIQEANAISGKLKKHYVFGRHDASDKGS-SETS--IRVRNLQL
GVSTFWSLEKFEYKLAAMKELYENNGSNKG-DDIFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISDCLHDIQVHQIHNLSSSH--SSGLMEKSSTIYSTSAESFLPGICKELIGS
SVDFLRYSFDEEKTIADSLMSKLLKIYNGLLVISKAHEEQDEES---QDNLFSSDRAVQS
LTIQIACAFEQLVVLIKHWVNDFLPST-SIAKLEDELRQEVKELGSYLQLFLQGCCSDIP
SMVKEAQKKVIQSIQQAVKYVGKLAVLKGNKLYFLENSNNKAASGQEEFMDVICDSVGSG
MKILLDSGLEKTKELQQDL---LRHCAQNEVTKQMKANAMGLIKSLENIFSEWKTKSFRT
QVQEDDSGYQDSKKITDLALKFLNLNHCLEKIMQIIISALTGC--YSDVHLLK-NCVETI
CSLVSDLCSDFSEP---STSFDCCEKK--ISQVGHRELESLAKSLLLCFESEERLDLFKS
WESYNQDTRG-EEKEESNSSWPGCSRNKGVPKRVYELR--EASPAVSSGVCTPSRI----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENISLKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSSVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKTKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYGEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAKSKIKSFRR
QVQEENFEYQDFKKMANHAPEFLKLKHCLEKTIEIIISALKGC--SSDVNLLR-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKCVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINRTYVISASRKTADMPLTPNPVGRLALQRRTTR-NKESSLLVSEL-----EDTTEKT
AETRLTLQRRAKTDSAEKWKTAEID-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFVASSVPLDED--PQVIEMMADKKYKETFS-APSR-ANENVALKYS
SNRPP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTTKCSLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDTKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNIVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTNGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRSVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNSRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNR
DKTFTVQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDAFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCLDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---FRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGC--HSDINLLQ-TCVESI
RNLASDFYSDFSVP---STSVGSYESR--VTHIVHQELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-PPSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQKSWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNV-EETL---STL-RYANQARLIVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRMKLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKLILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKVAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKKLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDIVPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAARVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKKMANCAPEFLKLKHCLEKAIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKDLESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EY-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSVHTSLNRHSSDT---LEGCQKTSSLSGLTHSNRLKIYLKSNMSESENHDPVLSAGSKA
RDINSTYVISACKKTRETPITPDS-SRLTLQRRATW-NKESSLLGSEL-----GDTTTKT
ADTSLRLQRRHPK---------------------TDFVEKLETTYTVGGDKENNCASQGT
RTKA-KLVNNNTGV--VSSVVSMED--SNDIGVMVGEKRKDIFPAL--STANERGTVKNS
NGRMP-VGSQCQTGVVRSGHL-AVKPVENKLDVKVSEAGEPHHGNTGKDIAKTV-HKVGN
LET--------------------------------------------------RTPVQCV
P-EHRLAPRHTLPPPKSPAVS-TLKNRLA--SPQVKQRP--KSALL-ANKRDHSQEST--
----LPPEEKSAVQN-TFTEADPVRAENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKMEKASQIVFRNGEEI
T-VEHPDMKQIYSFIYDV---------LFWSFDDCHPGYASQTTVYESLAAPLLQR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQVAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCTT
AHTSGERLKEGVSINK-SLLTLGKVISALSDQA-SGKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

IT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGIRPSSRH--NLTVEGPKDFEFAKNELLRAQRSQLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIRALEAELREESQRKKMEEINNQKANDKIEELEKAK
QHLEQEVYVNKRRLEMETLATKQALEDHSIRHARILEALEIEKQKIAKEVQILQENRGNR
DKTFTIQPNWSSMKLSMMIQEANAISDRFKKYYVFGRHDTSDRGR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKEFYESDGGNRA-EDVFCDPEDEWEPDITSTPVSSLSRR-RS
RSLMKNGRISGCLHDIQVPPIQNLHSSH--SSGLMEKSNTIYSNSSESFLPGICKELIGS
SIDFLGQSYDEEKTIADSLINNLLKLYNGLFAISKAHEEQDEES---QNNLFSSDRAAQA
FTVQIACAFEQLVVLFKHWLDDFPPGT-SSTRLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMIQEAQNKVVQIIQQAAQCVGQLAVLKGSKLCLLENSSKI--PGAREFTAALQDGMALG
IKSLLASGLEKVQDLEGNL---SRQSAHEEVTRRMKANAVELVRSLANIFAEWRLKSFRN
QVQENS--RQQGSKMLTLASEFLKLKYCLEKTIEIITSALRGC--PSDLHCLR-SYTETL
CGLAHKLHSDFTEP---PASAGNCGNK--VPRADYGELESLAKSLLLCFECGERPGLLQP
QESCNQNSKE----EQREASGADCSR--GLPTQAWELPRDPVAPEVSSQDCTPNRI----
--QWV------

MSIYTVSVNKP-YKAQCTATLQKTSSQNAFTSSKMLGQQLPSQVSGNNQDSLLSCSQNKS
EEVNRTYVISACSNADDTSLTLRPPGRLTLRRRTRT-SKNLASGGGQPDKNTPQGTESTQ
MEKRLTLQRRVKSGSVEKSTINGSTVPGAENSV-FDAERKYK------------------
-IALQPSISNNDTHYIKSSCKLAEG--QQVINLNSKFHSKDVFGNV------ENDDCVHS
KCRMDAADARFPKEVPVSEQLATSKYVNQVSGEQLHEKGDIK-RMAGKQRLQQL--KYNS
LER-------------------------------------------------PRTPTKAS
TEGFKLTPKNSTFQVKSSLSA-SSKQTADLPTVSEKK----TSSSP----GGRS------
--AKADEDAE----S-DSAEKDTFKVENSKVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 818)

RVRPFSSREKNESLLPVVSMSGSET
S-VRNPSTNQLYNFSYDF---------SFWSFDECHPNFASQETIYKTLALPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFDE-DRGIIPRLCEDLFTRIAQT-DQQQVLYHLEMSY
FEVYNEKIHDLLVFKAESRQKKQPLRV-REHPVLGPYVEDLTVNVVSSYSDIQ-SWLELG
NKQRATAATVMNDKSSRSHSVFTLVMTQTKVKSVDEEQRDHRLTSHVNLIDLAGSECCST
AQTTGERLKEGVSINK-SLLTLGRVISALSKLSRNGKKTFIPYRESVLTWLLK---ESLG
GNSQTAMIATISPAASNA-EETL---STL-RYAKQAC

ENSGT00890000139327_5_Linker_0_2 (818, 874)

SIINMAKVNEDVNAKLIRE--LR
AEIEKLKAAQKSAQNRDPEKYRHYLQEITSLRI

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHRQERDMTEM---QRAWKAKLEQAE
KRKLEDIKELQKAGIAFKMDNRLPNLVNLNEDPQLSEVLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GET

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGRYTANSKHD
IQLSGVLIADDHCVIKNTTGQVSIIPRREAKTYVNGKCIVNPTVLHHGDRVILGGDHYFR
FNHPVEVQKVKGLSCGT--TLLHDGPKDFEFAKNELLIAQRAQLESEIEEARIKAKEEMM
QSVQIAKEMVQQELTSQKEAYESKIKSLEAEVREESRKKQVQELNNQKAASKIQELEKAK
QNLELELHFNRKRLEMEALATKQALEDHTIHHAKILKALEDEKQKIAEEIQTLQKNRASG
NKTVNTPLNWNSLKLSVMIKEANTISNELGKNTVFNRHDKIDDKTGSVSSVQVQVRNVKL
RIATFWSLEKFECKLAAMKELYESNDSNKA-ADVFYDPADEWEPDLSDASVSSLP-RRRC
RSFMKNKRISGCLSGIKLQPIQNTQASY--ISGTQNK-SSIQPNFFDSLFPGICKESISS
ALDLLEQNHEGGKSIADHLLINLFTISSGVSAISKAYEQQEEEC---QKNFMSLDHDAQS
YSIKITSAFDQLVVLIKTWLNNVQKCT-GSMKTDEEIKQEVKNLGGYLQLLLQGCSSDIS
SMVTEAQSKVNEAVKQTMKCVGYLAVLTRTDISFFEENSISTISLQ-DFVRAAYDGVGSG
LEVLMDTLQEKARMTQNEL---VKQYPQNEIQSQIKDSTVALARFLESNVSHCRKTGIQS
QLPEEECLYQEIKRSTNIAAKYLELERCLSEVHQIVSSTLQGS--FRNTSLLR-SFAGEI
SIIAGYFNNYFSLLALSS--ANNPFQRTPMPFKNLDELDSLVDSLILSFELEQGQQKPKS
QVACNGTTETEGR-RVETDEKNHPRRSVSSE------------------------Y----
-EYWITQEAFK

MSVHTSHSRHN-IGSLEVSSSQKISASSGLVHSSRLELHLKADMSECENHDPFVNAGSKT
IDINSTYVISACKKTRETPVTSDP-RRLSLQRRATCGDRESSLLGSEL-----GN--RRT
ADTSLRLQRRH-G--------------------RADYVGKWETLNPVGGNPGSDSASQAS
RTE-AKGVNNDT--RVLSSVVSVKD--SNDTGL---TRCKDPGP--PVGASNEKVTVKDT
NSRAP-VGSQRQTEAMRSGHL-VVQLTESKSDTPVSGGRNSHRGNAGKDTAKQV-GTFGS
SDTRTPVKCVLEHRWTPRHDPPPPKSPALSTPKNNGKDIPKHGSTFRSASSESRTPVKCV
P-EHRWTPRHDLPPPKSPALS-TLKNRIA--SPRVKPRP--KSSLF-ANKRESSREST--
----LPPEENSLVQK-TFTEPDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKTEKASQVVFTNGEEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPGYASQTTVYETLAAPLLDR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQIAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRA-REHPVSGPYVEGLSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITSRINLVDLAGSERCST
AHSSGQRLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESTLTWLLK---ESLG
GNSKTAMIATVSPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRSNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEI---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

VT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHTPSSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFR
FNHPVEVQKGKKLSSRN-NLTTSEGPKDFEFAKNELLTAQRSRLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAVYERKIQALEAELREESQRKRLEELNNQKASHKIEELERAK
QHLEQEVYVNKRRLEMETLATKQALEDHRIRHARILEALEIEKQKIAEEVQMLQENRGNR
DKTFTIQPNWNSMKLSTMIQEANAISDKFKKCYIFGRHDASDKGR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNGGDRD-EDVFCDPADEWEPDITSTPVSSLSRR-RS
RSLMKNRRVSGCLHDI--HPIQSMQSSH--SSGLMEKPSTIYSNSSESFLPGICKELIGS
SIDFLGQSFDEEKTIADSLINNLLRLHNGVIAISKAHEEQDEES---QDNLFS-DRAAQA
LTIQVACAFEQLVVLFKHWLGDFLPCT-GSARLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVMKIIQQAVQCVGQLAVLKGSKLCVLENSSKV--SSTQEFMAALQDGVTSG
MKSLLDSGLETAQDLRQDL---SRQSAREEVTKQMKASTVEWVGSLENAVAEWRTKSFRT
QAQEGS--RQQVSKLLSLASEFLKLKSCLQQTVEMIVSALRGC--PSDLHCLR-SCTETI
CSLARKLHSDFSAH---SASAGSCGNE--LPRADCEELESLAKSLLLCFECGESPGLSKP
WESCSSNSKE----EQCKSDRADCGK--SGPRRACEPHGD-ATPAVSSGDCTPNRI----
--QWV------

MSVHTSHSRHN-IGSLEVSSSQKISASSGLIHSSRLELHLKADMSECENHDPLVNARSKT
VDINSTYVISACKKTRETPVAPDA-GRLTLQRRATCGNKESSLLGSEL-----GDTTRRT
ADTSLRLQRRH-D--------------------RADYVGKWETSDPVGGNPGSNSASQAA
RTE-AKRVNNDT--CVLSSIVSVKD--SDDTGL---MKCKDPCP--TVDASNEKVTVKDT
NNRVP-VGSQRQTEAMRSGHL-VVPPTESKSATQVSGGRNSHRGNADKDTVKQV-GAFGS
SDTRTPVKCVLEHRWTPRHDLPPPKSPALSTLKNNGKDIPKHGSTFRSSSSEARTPVKCV
P-EHRWTPRHDLPPPKSPALS-SLKNRIA--SPRVKPRP--KSSLF-ANKRESSQEST--
----FPPEEKSTVQN-TFTEPDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKTEKESQVVFTNGEEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPDYASQTTVYETLGAPLLDR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQIAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEGLSMNVVGSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITSRINLVDLAGSERCST
AHLTGERLKEGVSINK-SLLTLGKVISALSEQA-NGKRVFIPYRESTLTWLLK---ESLG
GNSKTAMIATVSPAASYI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRD--LK
AEIEKLKAAQRNNRSIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEI---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQIDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

VT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKHTSSSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFR
FNHPVEVQKGKKLSSRN-NLTTSEGPKDFEFAKNELLTAQRSWLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYECKIQALEAELREESQRKRLEEINNQKASHKIEELERAK
QHLEQEVYVNKRRLEMETLATKQALEDHRIRHARILEALEIEKQKIAEEVQMLQENQGNR
DKAFTLQPNWNSMKLSTMIQEANVISEKFKKCYIFGRHDASDKGR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAALKELYESNGGNTG-EDVFCDPADEWEPDITSTPVSSLSKR-RS
RSLMKNRRVSGCLHDI--HPIQSMQSSH--SSGLIEKPSAIYSNSSESFLPGICKELIGS
SIDFLGQSFDEEKTIADSLINNLLKLYNGVIAISRAHEEQDEES---HDNLFS-DRAAQA
LTVQVACAFEQLVVLFKHWLGDFLPCT-GSARLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVIEIIHQAVQCVGRLATLKGSKLCVLENSDKV--SSAQELMAALQDGVISG
MKSLLDSGLATAQDLRQVL---SRQSAREEVAKQMKASTVEWVRSLENAVAEWRMKSFRT
QVQEGS--RQ-VSKMLTLASEFLKLKSCLQKTVEMIVSVLRGC--PSDLHCLR-SCTETI
CSLAHKLHSDFSAL---SASAGSCGDE--LPRADCEELESLAKSLLLCFECGESRGLSKP
WESCSSNSEE----EQCKPGRADCGR--SGPRRSCEPHGD-ATPAVSSGACTPNRI----
--QWV------

MSVYNAHNRNN-RDVLGIPSSPKSSSLNVLTHSSRRKLHLNSDMSECENDDPLLRSASKM
RDINSTYVISACKKTGEVPLTPDPVGRLALQRRVTR-NKESSLCGSEL-----GASTEKT
AETRLTLQRRAKTESVEKWKTAQTDSV--------------KITQNVGSPTENDCASLEA
RRKV-TIINNDKDSFAAPFVPLAED--PKDIEMMADEKHKETFS-ALPG-ANEHVALKYL
SNRAP-TDPQSQTKVVSSGHL-TTKPLQSKLNIKVPGTANLHHRSIGKDMAKNS-NKFES
LEK--------------------------------------------------RTPVKYI
V-GHKWTPKCGTPQLTGPAAS-TLKNRVP--GLQVKQKP--RSSLL-TNERERSQENT--
----LPLEEEMAGRN-TSIETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKREKVEKASQVVFMNGEEI
A-VEHPDMKQVYNFLYDV---------AFWSFDECHPNYASQTTVYQTLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGLSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFSLVMTQTKTESVEGEEHDHRITSRINLIDLAGSERCST
AQASGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAANNI-EETL---STL-RYASQARMIVNIAKVNEDVNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEM---QRVWKEKFEQAE
RRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGT

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGKYKPNSSHD
IQLSGVLIADDHCTIKNFDGIVSIIPVGEAKTYINGKHILESTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TLTSEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELKEEAQRKKMQEINNQKANDKIEELEKAK
QRLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNQSNR
DKTFLIQTNWSSMKLSMMIQEANAISSKFKKCYVFGRHDVSDKGSSSDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNNSNKS-EDVFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISGCLHDIQAHPLQNLHSSH--SSGILEKSSAIYSSSAESFLPGICKELIGS
SLDFLGQSYDEEKTMADSLINNFLKIYHGLFAISKAHEEQDEES---QDNLFSSDRATQS
LTIQVTCAFEQLVVLVKHWLNDIVPCA-STARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKIIQIVQQAVKYVGQLAILKGSKLHFLENSSNKAASVQEDFVDALCDGVGLG
MKILLDAGLEKAKELRHEL---LRQCTQNEVTKQMKAKAMGLIGCLENMFAEWKTKSFRT
ELQQENSGYQDLKKMVNLAPELLKLKHCLEQTIQIIISALRGC--HSDKDLLK-NCVESL
CNLAKDFHDDLSMR---STSLDSCEKR--IPQVGHGELESLVKSLLLCFESEERPDLLNP
WEPCNQNTRE-EG-QQSKSSRTDSVRSKGVPKRVYELH--GLLPAVTSEDSTPSRI----
--QWV------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------EREKREGAHQAVFLD

PF00225 // ENSGT00890000139327_5_Domain_0 (477, 819)

EEEI
A-VEHPGTRQVYSFAYDL---------SFWSVDERHPRFASQMAVYQALAAPLLGQ--AF
QGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAEIAKK-QTQEVSYHLEMSF
FEVYNERIHDLLVCKGENGQRKQTLRV-REHPASGPYVEGLSTNVVSSHSDIQ-VWLQLG
NKQKATAATGMNDKSSRSHSVLTLVMTQAKTEFVEGEELDHRIRSRINLVDLAGSERCSA
TGTSGERLKEGVSINK-SLLTLGKVISALSEQA-GGRSVFIPYRESVLTWLLK---ESLS
GNSKTAMVATVSPAGSSVEE-TLS---TL-RYAAQARSIVTAARVNEDLSAGLIRE--LK
AEIEKLKAAQRSSQNIDPERYRLCRQEIASLRMKLHQQERDMANM---QRMWKEKLEQAE
KRKLQVTKELQKAGITFQMDNHLPNLVNLNEDPQLSEILLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYRPSSSHD
IQLSGVLIADDHCTITNSSGTVSIVPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFR
FNHPMEVQKGEQPPSRE--NPVSKRPEDFESAKNDLLTAQRLQLEAEIKEAQVRAKEEMM
QGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNQKANHKIEELEKAK
QRFEQEIHVNRKRLEMEALATKQALEDHRIRHAKILEALETEKQRIAQEVQSLQQSQSHR
GKAFTVQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSFDTC--IRVRNLQL
GVSTVWSLEKFESKLAAMKELYESHGSSQG-EDVFCDPEDEWEPDITDVPVSSFSRR-RS
RSLMNNRRVSGCLHDIEAHAGQDLRSSGSA--GLVGKSSPVYLESAEPFLPGICKELISS
SLELLGQSDDEEGTVADSLMSNFLRIHDGVLAVSRAHEEQDEDS---QCNLFA-DRANQS
LTVQVASAFQQLTVLTAPWVSGVPLEA-GRAALLAELRREVRTLGGRLQLFLQGCSSDIS
PMVKEAQKQVIQTVHRAVACVGRSVALGGDRLHFLESSAHGAAGLQDDFVGAVCDGVDLG
IKSLLNSGIEKAKELEHEL---LRQSPQAEVTKQMKANALGLIESLGNLFAEWKTKSFRT
QVQEENSEYEDLKKMINLAQEFFKLKCGLEQTIQIIISALRGH--RGDVALLQ-DCVQRL
CSSARGLHGDWGGCP---------EDS--RAQAGHRELESCATSLLLGFEFEEGPGLWGP
WETCDQGPRAAGQ-EQPGSDRPGPQRTRGVPKRVYELP--GLALGGSEQDVLPTCEGA--
-----------

MSVHTAHNRNN-----SITSTPKSSSLSALTHSSRLKLHLKSDMSECENDDPLLRSASKT
RDINSTYVISASTKTEGISLTPNPVGKLALQRRTTR-NKESSLLGSES-----GETTEKT
AEKCLTLQRRAKTDSSEKWKTAKTD-----------YIEKWKTMQDVGGERENNCASKET
TTNV-NVVNNVKNSFVASSIPLAKD--PKDIEMVADEKYKETFS-ASSG-ANENVALKYS
SNRAP-IGSQDQTEVVKSGHL-AAKPIQSKLDVKVLGIGNLHHRSIGKDLAKNS-NKFGS
LEK---------------------------------------------------TPMKCI
T-DHKLTPKSGMPQLKSPAAS-VLKNRMP--NLQVKQRP--KSSLL-ANKRERSQENT--
----LPAMEETAVQN-TSKETDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFTKREKIEKASQVVFMNGEEI
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYERLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVAKK-QSQEVSYHLEMSF
FERKQP------------VRLKQSIIL-REHPVSGPYVESLSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
ARTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYASQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
RRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCSIKNFGGTVSIIPVGEAKTYINGKCILEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TLISEGPKDFEFAKNELLMAQRSQLEAEINQAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELKEESQRKKMQEINNQKANHKIEELEKAK
KHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVEILQQNRSNR
DKTFTIQTNWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKGS-SDTS--IRIRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRS-EDVFCDPEDEWEPDITNAPISSYSRR-RS
RSLMKNRRISGCLHDIQVYPIQNLHSSR--SSGVMEKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEEKTIADSLMKNFLKIYDALFAISKAHEEQDEES---QDNLFSSDRATQS
LTIQMACAFEQLVVLIRHWLNDLLPCT-SIAKLEDELREEVKKLGGYLQLFLQGCCSDIS
SMVKEAHKKVIQSVQQAVKCVGQLAVLKGSKLHFLENSDNKAASVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTQSEVTKQMKANAMGLIRSLENIFAEWKIKSFRT
QVSEETPGYQDFKKMINLAPEFLKLKHCLEQTIQIIISSLRGC--SNDVNLLK-NCVESI
CSLAGDFSSDCSVP---STSADGCEDR--GPHVGHREVESLAKSLLFYFESEESPDLLKP
WETCNQNPIE-EEQQQLKSSRADCSKEKGVPKRVYELH--GSSPAVSSEGGTPSRI----
--QWV------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------M

PF00225 // ENSGT00890000139327_5_Domain_0 (525, 819)

IYKALAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFGE-ELGIIPRFCEDLFTQIAQM-DSQKILYHLEVSY
FEVYNEKIHDLLIFKAENGQKKQPLRV-REHPVFGPYVEDLTANMVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVLTLVMTQTKTEFVEEEEHDHRIISRINLVDLAGSERCSS
THTSEERLKEGVSINK-SLLTLGKVISALSEQSLNKRRAFIPYRESVLTWLLK---ESLG
GNSKTTMIATISPAASNV-EETL---STL-RYAKQARLIINTAKVNEDVNAKLIRE--LK
AEIEKLKTARKSTLNSDPEKYSQCLQEITSLRVKLHQQERDMAEM---QRAWKEKLEQAE
RRKFEETKELQKAGITFKMDNRLPNLVNLNEDPQLSEMLLYMIKEGQT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSHHD
IQLSGVLIADDHCVIKNIDGRVSIMPLGEAKTYVNGKHISESTVMHHGDRVILGGDHYFR
FNHPIEVQKVKIPSCGT--VLSCDGPKDFEFAKNELLVAQRSQLESEIEEARLKAKEEMM
QDIQVAKEMAQQELISQKKIYECKIKSLEAELREESHKKQIQEMNNQQSANKIQELEKAK
QHLELEVHFSKKRLEMETLATRQALEDHTIRHAKILEALEAEKQKIAKEIETVQQNRGNG
NKTI--KPNWDSMKLSLMIKEANAISSKLGKHTVFRRYDISEKGNGTGSSIQVQVCNIKL
GIATFWSLEKFEYKLATMKEVYESNGSNKA-DDVFYDPDDEWEPDLRTTNVSSFS-RRRS
RSFMMNKRISGCLSDIKLQSLQNLQTSH--LTGPVNKSNSICSSSSESFLPGICKELIGS
ALDLLGQNHEEEMFIANSLLANLFTIYSGVTTISNAYEQQDEES---QENFFSLDRATQS
CSIRITSAFEQLVILTKHWLNSLQKCT-DSIKIDEELRQNIKNLGSYLQLLLQGCFSDIS
SMVTEAHNKIIQIVKQTGKHIGHLTALTGSDLHLSEENKEDATVSQKDFILAIYDGVGSG
LKRLLDSVQKKIREMQKEL---LKQYPQNEVQNQIKNNAMAFARSLENTVLDCKKKELGS
QLIKEESVHQEIKKATNLASEYLELEQCIDKVSQIITTSLQGS--YRNTNPLR-SYTEKI
CILVGHFNNYSNLLSLSSASPNRPTHTTAKSFMVTSELDSQAKSLIISFELQQGHNSLAS
QAICMQNNKTEEK-QLELGE--STSKPKGIPKREYRLQ----TSATDSGDLSPSGI----
--QWV------

MSVHTSLNRHSSDT---LEGCQKTSSLSGLTHSNRLKIYLKSNMSESENHDPVLSAGSKA
RDINSTYVISACKKTRETPITPDS-SRLTLQRRATW-NKESSLLGSEL-----GDTTTKT
ADTSLRLQRRHPK---------------------TDFVEKLETTYTVGGDKENNCASQGT
RTKA-KLVNNNTGV--VSSVVSMED--SNDIGVMVGEKRKDIFPAL--STANERGTVKNS
NGRMP-VGSQCQTGVVRSGHL-AVKPVENKLDVKVSEAGEPHHGNTGKDIAKTV-HKVGN
LET--------------------------------------------------RTPVQCV
P-EHRLAPRHTLPPPKSPAVS-TLKNRLA--SPQVKQRP--KSALL-ANKRDHSQEST--
----LPPEEKSAVQN-TFTEADPVRAENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKMEKASQIVFRNGEEI
T-VEHPDMKQIYSFIYDV---------LFWSFDDCHPGYASQTTVYESLAAPLLQR--AF
EGYNTCLFAYGQTGSGKSYTMMGLNE-EPGIIPRFCEDLFAQVAKK-QTSEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCTT
AHTSGERLKEGVSINK-SLLTLGKVISALSDQA-SGKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYATQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 947)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEG

ENSGT00890000139327_5_Linker_2_3 (947, 949)

IT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIRNFGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVILGGDHYFR
FNHPVEVQKGIRPSSRH--NLTVEGPKDFEFAKNELLRAQRSQLEAEIKDAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIRALEAELREESQRKKMEEINNQKANDKIEELEKAK
QHLEQEVYVNKRRLEMETLATKQALEDHSIRHARILEALEIEKQKIAKEVQILQENRGNR
DKTFTIQPNWSSMKLSMMIQEANAISDRFKKYYVFGRHDTSDRGR-SDTS--VRVRNLQL
GISTFWSLEKFESKLAAMKEFYESDGGNRA-EDVFCDPEDEWEPDITSTPVSSLSRR-RS
RSLMKNGRISGCLHDIQVPPIQNLHSSH--SSGLMEKSNTIYSNSSESFLPGICKELIGS
SIDFLGQSYDEEKTIADSLINNLLKLYNGLFAISKAHEEQDEES---QNNLFSSDRAAQA
FTVQIACAFEQLVVLFKHWLDDFPPGT-SSTRLEDELRQDIKKLGGYLQLFLQGCCSDIS
SMIQEAQNKVVQIIQQAAQCVGQLAVLKGSKLCLLENSSKI--PGAREFTAALQDGMALG
IKSLLASGLEKVQDLEGNL---SRQSAHEEVTRRMKANAVELVRSLANIFAEWRLKSFRN
QVQENS--RQQGSKMLTLASEFLKLKYCLEKTIEIITSALRGC--PSDLHCLR-SYTETL
CGLAHKLHSDFTEP---PASAGNCGNK--VPRADYGELESLAKSLLLCFECGERPGLLQP
QESCNQNSKE----EQREASGADCSR--GLPTQAWELPRDPVAPEVSSQDCTPNRI----
--QWV------

MSVSTARNRND-SDTVGIPSSQKNSSLNVLSHNSRVKLHFKSDMSECENYDPLFRSASKI
KDINSTYVISACRKTEDLPLIPKAVGRLTLQRRVTR-DKEAFLLDSEP-----GVTTEKT
AEKRLTLQRRPKTDSVEKWK----------------------TPQKMGGERRNSSVSQET
NRNV-KTVETDKNSLVASSIPSAED--SKNTEMMTDKKYKETFSAA--RNENGNAALTNV
GHRVP-AGSQSLTDAGRSGCW-TTKPAQSKLDVKVSTTENPHHRSIGKDTAKNSASKLGT
LGK-------------------------------------------------GRTPTKCV
A-EHTLTATCSTPKLKSPAVS-VVKKRMP--SLRVQLRP--GNSLL-ENKSERSQENT--
----LPPEEETTASN-TCTETNPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKREEMEKASQVVFMKGEEV
M-VQHPDMKQVYSFTYDV---------SFWSFDKCQPNYASQTTVYETLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCDDLFAQIAKK-QTEEVDYHVEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDLRIISRINLIDLAGSERCFT
AHSSGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRIFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPADCNI-DETL---STL-RYANQARLIVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNHQHIDPERYKLCRQEITSLRMKLHQQERDMAEM---QRVWREKFEQAE
KKKLQETEELQKAGIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXSNGGNRD-EDIICDPDDEWEPDFTNVPVSSFSRR-RS
RSLLKNRRISGCLHDMQIHPIQNLHSSH--SSGLMEKSSMIYSNSAESFLPGICKELIGS
SLDFLGQSYDEEKTVADNLINNFLKIYNGIFAISKAYEEQGEEI---HDNLFSSDRATQS
VTIQVACAFEQLVVLIKHWVNDFLACT-STARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKVIQIVQQAVKYIGQLAVLKGSKLHFLENSNNKAANLQEDFMDAVCDGVGLG
MKLLLDSGLEQTKELQPEL---LRLCAQNEVTKQMKANAMELIKSLENAFTEWKMKSFRI
QVQEDNSGYQDLKKIINLAPEFLKLKHCLEQIIQITMSALKGS--HTDVNLLTRYWVESI
CNLAGDFHDYFSQP---TTLVNSCENG--APPDGHRELESLAKSLLLCFESEEKPDLLKP
WETCNQSNREDQ---RSKSSRTESDRKKGVPKRVYELH--GSSPAVILKECTSSKV----
--QWV------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------TLAES-SSTGEDVFKVKNSKVIVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 818)

RVRPFSNREKTENSFPVISMSGSET
I-VQNPSTNQVYSFSYDF---------SFWSFDKDHPNFASQAMIYKTLALPLLER--AF
EGYNACLFAYGQTGSGKSYTMMGFDE-DRGIIPRLCEDLFNQIAQM-DKEQVLYHLEMSF
FEVYNEKIHDLLVFKAENGQKKQQLRV-REHPVLGPYVEGLTVNVVRSYSDIQ-SWLELG
NKQRATAATVMNDKSSRSHSVFTLVMTQTKVEFVNEEQCDRRLTSYINLIDLAGSECCTK
AQTTGERLKEGVSINK-SLLTLGRVISALSKQSQNGKKTFIPYRESVLTWLLK---ESLG
GNSQTTMIATVSPAASST-EETL---STL-RYAKQACSIINIAKVNEDMNVKLIRE--LK
AEIEKLRAAQKSALNTDREKYRRYLQEITSLRVELHQQERNMAEMQ---RAWKEKLEQAE
KRKLEDIKELQKAGIAFKMDNNLPNLVNLNEDPQLSEVLLYMIKEGE

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGRCTPNSKHD
IQLSGVLIADDHCVIKNTVGKVSIIPLREAKTYVNGKCILDPTILHHGDRVILGGDHYFR
FNHPAEVQKVKTPSCGT----LHDSPKDFEFAKNELLIAQRAQLESEIEEARLKAKEEMM
QSVQIAKEMVQQELTSQREVYESKIKSLEEEVREESRKKQIQELNNQKATTKIQELEKAK
KSLELELHFNKKRLEMETLATKQALEDHTIRHAKIVEALEAEKQKIAEEIHALQKNPGSG
NKPVMTPLNWKSLKLSVMIKEANAISNALGKNTVFCRHDRIDDKTGTVSSIQVQVRNIKL
GITTFWSLEKFECKLAAMKEFYESNDRNKAVVDVFYDPADEWEPDLSDTSISLLS-RRRS
RSFMKNKRISGCLSEIKLQSIQNKQTSY--ISGSLNK-SSICSSISELFLPVICKESISS
ALDLLEQNHEGGKSIADSLLTNLFIVFSGASAISKAYQ-QDEEC---QENFFSLDRAAQS
YSIRIVSAFDQIVVISKLWFNNVQKCP-GSRKADEEMKQEIKNLGGYLQLLLQGCSSDIS
SMVTEAWNKVNQTVKQTMKYIGHLAVVTTTDISFPEESNIPASSLQ-EFVLAIYDGIGSG
LECLIDAVQEKARIVQKEL---VKQCAQNEV-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPEQYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVKILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
Q--EENFEYQDFKKMANHAPEFLKLKHCLEKTIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLIFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSRIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSLYAADNRNN-SDILGTPSSQKSSSLNVLTHSSRLNLPLKSGVSEYENDNQLLRSASKT
RDLNSTYVISACTKTGDRPPISSPAGRLALQRRATR-NKESSLLDSEL-----GDNTEKT
AETRLTLQRRAKTDSVEK----------------------WKTTQNVGGKTENNGASQET
SKNI-KIVNTDINSFVASSVPLAED--PKDIQIMTGEKYKETFSVPSRTN--ENVVLKYL
SNRAP-IGSQNQNESARSGHL-VTKPIQSNLDIKVTETESLHHRSVGRDIVKNSSNKFGS
LEK-------------------------------------------------GRTPTKCV
T-EHKSTPKRSVPQFRSPASF-IPKNRMS--SFQVKQSP--KTSLL-ANKRERSQENA--
----LHPEEETALQN-TFTEKDSLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RIRPFSSREKIENASQVVFMNGEEV
I-VQHPNIKQIYNFIYDV---------SFWSFDECHPNYASQTTVYEKLAVPLLER--AF
EGYNICLFAYGQTGSGKSYTMMGFKE-EPGIIPRFCQDLFAQVAKK-QTQEVSYHVEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPISGPYVEALSMNVVSSFCDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRIVSRINLIDLAGSERCST
AHANGDQLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFIPYRESILTWLLK---ESLG
GNSKTAMIATISPAVSNI-DETL---STL-RYAKQARLIVNIAKVNEDVNAKLIRE--LK
AEIAKLKAAQRSNRNVDPERYRLCQQEITSLRMKLHQQERDIAEM---QRVWNDKFEQAE
KRKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGKT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPTSSHD
IQLSGVLIADDHCIIKNFDGIVSIAPVGEAKTYVNGTHILEPTVLHHGDRVILGGDHYFR
FNHPIEVQKGKRPSCRD--TLVSEGPKDFEFAKNELLMAQRSQLEAEIQEARLKAKEEMI
QGIQIAKEMAQQELSSQKVAYESKIKALEAELKEESQRKKMQELNNQKANYKIEELEKAK
QHLEQEI-VNKKRLEMETLATKQALEDHSIHHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTVQPNWSSMKLSMMIQEADAISNKLRTYYVFSRHDVSDKESSSETSVQVQVRNLQL
GISTFWSLEKFESKLAAMKELYESSGSNRG-EDVFCDPEDEWEPDITNTSVSSLSKR-RS
RCLMKNRRISGCLHDIQVHPIQNLHSSH--SSGLMEKSNTIYSNSAESFLPGICKELISS
SLDLLGQNYDDENSMADSLINNFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRATQS
LTIQITCAFEQLVVLIKHWLNGFLPCI-STVRLEDELREEVKKLGGYLQLFLQGCCSDIS
SMVKEAQNKVIQTIQHALKYVGQLAVLKGNKLPFLENSNNKAVIHQEDFMDALCDGIALG
MKILLDSGLEKAKELQREL---QKQYTQNEVTKQMKANAMGLISYLENVYVEWKTKSFRT
QVQEENFGYQGSKMMTNLAPEFLKLKHCLEQTIQIIISTLRGM--YFKWNL---------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINRTYVISASKKTADMPLTPNPVGRLALQRRTTR-NKESSLLVSEL-----EDTTEKT
AETRLTLQRRAKTESAEKWKTAEID-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFVASSVPLDED--PQVIEMMADKKYKETFS-APGR-ANENVALKYS
SNRPP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-VLKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNIVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTNGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRSVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQIACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLRFLENGNNKAASVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---FRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGC--HSDINLLQ-TCVESI
CNLASDFYSDFSVP---STSVGSYESR--VTHIVHQELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSASTAH-SRNDRDLLGVPSSTKTSSLSVLPQGSKLKLHPRSDSSECENDDPLLRSASKV
RDINSTYVISACKKTEDTRLLPNPVGRLTLQRRATR-SKEPSLLGRES-----GDAGAKT
AETRLALQRRTKTDCMGK----------------------WKGMQDVGGRTENSRPSPET
GISV-KAVSSDKDLPVAPSVSLTPD--PKDPEMKADGKCAATRSAL--SGVGENVALKSL
RERAP-AGSQSQTEAVRTPCV-AVRPTESRLETRVSGAGASHHRGAEKEAMKLP-RRFES
LEK--------------------------------------------------RTPFKCI
S-EPRSTPRRGVLQPRSPAAL-VLRSRRP--TLQVKQTP--QSSLL-ASQRERSRENT--
----FLLEEETALQK-TSAETGPLKVESSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSSREKREGAPQAVFLDGEGI
V-VEHPGTRQVYSFAYDL---------SFWSVDERHPRFASQMAVYQALAAPLLGQ--AF
QGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAEIAKK-QTEEASYHLEMSF
FEVYNERIHDLLVCKGENWQRKQTLRV-REHPATGPYVEGLSTNVVSSYSDIQ-VWLELG
NKQKATAATGMNDKSSRSHSVLTLVMTQAKIEFVEGQELDHRIRSRINLVDLAGSERCSA
TGTSGERLKEGVSINK-SLLTLGKVISALSEQA-GGRSVFIPYRESVLTWLLK---ESLS
GNSKTAMVAAVSPAGSSVEE-TLS---TL-RYAAQARS

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVTAARVNEDLSAALIRE--LK
AEIEKLKAAQRSSQNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERHMADM---QRVWKEKLEQAE
KRRLQVTEELQKAGIAFRMDDHLPNLVNLSEDPQLSEILSYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 953)

GTTTVGK

PF00498 // ENSGT00890000139327_5_Domain_3 (953, 1014)

CGPGSSHD
IQLSGVLIADDHCTITNSDGTVSIIPAGEAKTYVNGKLISEPTVLHHGDRVILGGDHYFR
FNHPMEVQKGEQPPSRE--NPVSKGPEDFESAKNDLLMAQRLQLEAEIKEAEVRAKEEMM
QGIQIVKEMAQQELSSQKAAYESKIKVLEAELKEESQRKKIQEINNEKANHKIEELEKAK
QRFEQEIHVNRKRLEMEALAAKQALEDHRIRHAKILEALETEKQRIAQEVQILQQNQSHR
DKAFAAQPSWSSMKLSVMIQEANAISSRLNRNYVFGRHVVSDKGSSSDAC--IRVRNLQL
GVSTVWSLEKFESKLAAMKELYESRGSSRG-EDVFCGPEDEWEPDITHVPVSSFSRR-RS
RSLLNNRRVSGCLHDVEAHAGRDLRSSGCA--GLVGNSSPVYLDSAEPFLPGICKELIGS
SLELLEQSDDEEGTVADSLMSNFLRIHDGVLAVSRAHEEQDEDS---QCSLFA-DRANQL
LAVQVTSAFEQLAVLTGPWVSGVLLEA-GRAALLAELRQEVRTLGSRLQLFLQGCSSDIS
PMVKEAQKQVIQTVRQAIACVGRSVALTGGRLHLLESGAHGAAGLQDDFVGAVCDGVEMG
VKSLLDAGTEKAEELEHEL---VRQSPQDEVTKQMKANALGLIESLGNLFAEWKTKSFRT
QVQEENSEYKDLKKMINLAQEFFKLKCGLEQTIQIIISALRGH--RGDVALLQ-DCVQRL
CSSARGLHGDQAGCP---------EDS--RAQASRRELESCATSLLLGFEFEEGPVLWGP
WEAFDQGPRAAEQ-EQPRSDRPGPQGTRGVPKRVYELP--GPALGGSEQAVLSTREGAGE
GSPPAREQ---

MSLHSTHNRNNHGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTAEKT
AETHLALQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETGNNGVSKES
RTNV-RTVNNAKNSFVASCVPLDED--PQVIEMMADKKYKETFS-APSR-ANENIALKYS
SNRAP-IASLSHTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGNEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVKN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKHILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGRRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELQKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVADKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTVADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKKMANSAPEFLKLKHCLEKAIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTEE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSVYTARERNS-SNILGPSSSQKDPSLNGFSHSNRLELHLKLDVSQYENDDPSLKSANKL
RDINSTYVISACKKPGS--LTPDTAGKLTLQRRVTR-SRESSSLDQKP-----GDSAGKA
PETGHPFHHT-KTEQEAKPKT-------------------------VGSEPEKKVLSTIG
XXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-----XXX-------XXXX-----------------X-XX---------XXXXXXXX
X-XXXXXXXXXXXXXXXXXXX-XXXXXXX--XXXXXXXX--XXXXX----XXXXXXXX--
----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00225 // ENSGT00890000139327_5_Domain_0 (463, 820)

XEKMEKASQVVFQKGEEI
A-VEHPDMKQVYHFVYDV---------CFWSFDECHPGYASQSTVYETLAAPLLDR--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EAGIIPRFCEDLFARVATK-QSQEATYQLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYADIQXXXXXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXTELVEGEEHDHRITSRINLIDL-GSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NRKRVFISYRESVLTWVSFRCKGCLG
GNSKTAMIATISPAASNI-EETL---STL-RYASQARMIINVAKVNEDVNAKLIRE--LK
AEIEKLKSAQRNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGDRVILGGDHYFR
FNHPVEVQKGKRPCSRE--TFVSEGPKDFEFAKNELLMAQRSQLEAEIREAQLKAKEEMT
QGIQIVKEMAQQELSSQKAAYESKIRALEAELXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXALEDHSIRHARILKALEEEKEKIAKEVQILQQNQSNR
DKTFTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX
XXXXXXXXXXXXXXX--XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXS
RSLMKNRRISGCLHNVQAHPIQINGSSH--SSGIMEKSSAVYSNAAESLIPGICKELICS
SLDTFEQNYNEEKTMADSLLSSFLKIYNGLFAILKAYEEQDEES---QENLFS-DRATQS
LTLQVTCAFGQLLVLVPHWLDGVRPCC-NPAGLEDDLRQEVKKLGGYLQLFLQGCSSEIS
SMVKEAQTKVTEIVLQTVKHVGRLAVLAGSRLHFLESSAK-AAAAQEEFMEAIYDGVGLG
MKILLDSTLERAKEFQHTL---SRQYTQNEASKQMCAHATGLIGSLESIFAEWKTKSFRT
QVQEEDSGYQDGKKMANLASEFLKLKQCLEQTIQMTVSALRGR--PGDAPLFK-SSVNNL
CSLVRGLHAALGVHAAS------TDGNQETPRLGLQDLESVAKSLILCFGSELSPDLWEA
---GREKGRGGGP--QTGLGR------AGRDTTDWTA---ALDGAVSSEECTPRRI----
--QWV------

----MSAHPGNSSQILDVPCSL-----N----ALRYKKTVKTHVSGGEQADPLLTSVSKI
KGTDSSYVISACKKTGDIPVSPNPAGKWMLQRRGTR-HKESSLLGSEL-----GDPTEQP
GGTRLSLQRRAKTGCVEKQK----------------------AAQSVRAEAVEDHAPEEA
GTHV-ASERNGRTPLDVCSVPAAEG--LKDLPVTAPETRLEPLSAL--GGASAGGSLKCL
GGAVP-TASLSQG-DIRSGPS-AVKPIESQLGSR-------AWASAGKDVGKNL-NKCGN
LEK--------------------------------------------------KTPTKCL
A-EHNLTPKCSTPRFKSPATA-MLRTRAA--GLPANPRP--GSSLL-GRQRARSQEST--
----LPPEEDSAVQN-MCEEADTLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKREKIENASQVVFLNGDEI
C-VEYPDMKQAHTFTYAL---------SFWSFDESHPRYASQATVYEVLAAPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFAQVGKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVGKGENGQRKQPXXX-XXXXXXXXXXXXXXX-XXXXXXXXXXSWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTELVEGEEHEHRITSRINLIDLAGSERSGA
AHTTGDRLKEGVSINK-SLLTLGKVISALSEQA-NHRRLFIPYRESVLTWLLK---ESLG
GNSKTAMIATVSPAASSI-EETL---STL-RYASQARLIVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPGR-------ITSLRMKLHQQERDMVEM---QRAWKEKFEQAE
KRKHQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHD
IQLSGVLIADDHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGDRVILGGEHYFR
FNHPVEVEKGRRTPGRD--TLTSEGPKDFEFAKNELLVAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQRELSSQKAAYESKIQALEAELKEESQRKKVQELHTQEANHRIAELEEMK
QRLEQEVRVRSRRLEMEALAAKQALEDHSVRHTRILEALEMEKQKIAKEVQILQQNRSNR
DKTFTIQPNWSSLKLSMMIQEANAISSKFKKCYVFGRHDVSNKGH-VDTS--VRVQNLQL
GISTFWSLEKFESKLAAMKELYESNGNSKG-EDIFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPAQNLRSSH--SSGLMEKSSTICSKSAESFLPGICKDLIGS
SLDLLGKSYDEEKALADNLVDNFLIIYDGLFAISKAHEEQDEES---QDNLFSSDRAVQS
LTIRIACAFEQLVVLIRHWLNEFLPCA-SKERLEDEFRQEVKKLGGYLQLFLQGCCSDIS
SMVKETQKKVIQIVHQAVKYVGQLAVLSGSKLYFLENIDNKATNVQEEFVDAVCDGIGLG
MKGLLDAGWAKAEELQHEL---LRQCTHNEASSQMKENAVGLVSALEDIFTEWKK-----
-VQEEDSGSHDPRKMIHLAPEVLKLIHCLEKTIQIIISALKXX--XXXXXXXX-XXXGSI
CTLAREVHDDLSVP---SAPATCSGDA--VPHVAHRRLQSLAESLLQCFGSKEGPKLLEP
WESYNQNTRGGD--QQPGWSRTDCSS-QGVPKRVYELH--SLTAAVSSEECLPSRI----
--QWV------

MSVYAARNRND-SNILGIPSSQKNSSLNVLSQGSGLKLHSKSNMSECENDDPLFGSASKI
KDVNSTYVISACKKTGDLPLTPKPVGGLTLQRRVTR-DKESSLLGSEL-----GET----
AEKRLTLQRRAKTDSMEK----------------------WETTQKMGGETENTCASQEI
SRNV-KTVNTDKNSCVASSVPLAED--SKNVEMMTDEKYKQTFSAPRDGNENGNVVLKYL
SHRTP-TGSRSHIEAVRSGRL-VTKPSQNKLDIRVSGTENLYHRSIGKDIVKNSAIKLGA
LEK-------------------------------------------------GRTPVKCV
T-EHRLTPKRSVPQLKSPAAS-VLKNRMP--SLQVKQRP--KSSLL-GNKTERSQENT--
----LPPEEEAAAQN-TDIKTDPLKAENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RIRPFSKREKMEKASQVVFMNGEEI
T-VQHPDMKQAYNFIYDV---------SFWSFDECHPNYASQTTVYETLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCQDLFAQVAKK-RTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRL-REHPISGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTELVEGEEHDHRITSRMNLIDLAGSERCSA
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATVSPAGSSI-DETL---STL-RYANQARLIVNIAKVNEDTNAKLIRE--LK
AEIEKLKAAQRNNRHIDPERYRLCRQEITSLRMKLHQQEKDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGK

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGKYKPNSSHD
IQLSGALIADDHCTIENFDGTVSIIPVGEAKTYVNGRHILEATVLHHGDRVILGGDHYFR
FNHPVEVQKGQRPSCRDADTLISEGTKDFEFAKNELLLAQRSQLEAEIEEARLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELEEESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHAKILEALETEKQKIAKEVQSLQQNQSNR
DKTFTIQPNWSSMKLSMRIQEANAISNKLRKYYVFGRHDVSDRG-SSETSVQVRVRNLQL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISGCLRDIQVHPTQNLHSSR--SSGLMEKSSTIYSNSAESFLPGICKELIGS
SLNFLGQSYDEEKTMADSLINNFLTIYNGIFAISKAHEEQDEES---HDNLFSSDRAIQS
LTIQIACAFEQLVVLIKHWLNDVLACK-STARLDDELRQEVKKLGGYLQLFLQGCCSDIS
SMVKEAQKKVIQIVQQAVKYVGQLAVLKGSKLRFLENSNNKAVSLQEDFMDALCDGVGLG
MKILLDSGLEKTKELQPEL---LRLCAQNEVTIQMKANAMGLIKSLENVFTEWKTKSFRT
QVREENCGYQDLKKMVNLAPEFLKLKHCLDQTVQIIISTLRGC--HSDVSLLK-RCVESI
CNFASNFHDYFSHP---CNSVNSCENR--APPVGHRELESLAKSLLLCFESEERPDLLKP
RETCNQSTRE----QQSKSSRTESVRKKGIPKRVYELH--GLSSGVTSEENTSSRI----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SLWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLVDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDTPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAKSKIKSFRR
QVQEENFEYQDFKKMANHAPEFLKLKHCLEKTIEIIISALKGC--SSDVNLLR-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKLDMSECENDDPLLRSAGKV
RDINRTYVISASKKTADMPLTPNPVGRLALQRRTTR-NKESSLLGSEL-----EDTTEKT
AETRLTLQRRAKTDSAEKWKTAEID-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFVASSVPLDED--PQVIEMMADKKYKETFS-APGR-ANENIALKYS
SNRPP-IASLSQTEVVRSGHL-TTKATQSKLDIKVLGTGNLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAAKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYNFIYDI---------SFWSFDECHPHYASQTIVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHVEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTNGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARLIVNVAKINEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPEQYRLCRQEITSLRMKLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPAGEAKTYVNGKHILEITVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--APISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRYNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GVSTFWSLEKFESKLAVMKELYESNGSNRG-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVLLMKHWLSDLLPCT-DIARLEDELRQEVKKLGGYLQLFLQGCCLDLS
QV----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

MSLHTTYKRNDSGDILDIPSSQNSSSLNNLTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINSTYIISASKITGDMPLTLNPVGRLSLRRRTTR-NKESSLLASEL-----EDTTEKT
AETCLTLQRRAKTDSAEKWKTAETN-----------SVKKWQMTPNVGSKIESNCVSKES
RTNV-KIVNNAKNSFVASSVPLDED--SKVIEIMANKKYKGTFS-APSR-AKENVVLKYS
SNRTP-IASLSQTEVVRSGHL-ATKPTQSKLDIKVSETGNLYHRSIGKEIAKTS-TKFGS
LEK--------------------------------------------------RTPTKCI
T-EHKLTPKCSTPQLKSPASS-ILKNRMS--NLQVKQRP--KSSLL-ANKQERSAENT--
----ILPEEENAYQN-TSADKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMNGKEL
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSA
AHTGGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRLWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCIIKNFGGTVSIVPVGEAKTYINGKHILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGGRPSGRD--PLISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDGSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAAVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLLAISKAHEEQDEES---QDNLFSSDRATQA
LTIQTACAFEQLVVLMKHWLNDLLPCA-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLNGSKLHFLENSNSKAASVQGELMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTGNEVTKEMKTSAMGLIRSLENIFAESKIRSFRR
QVQEEHFGYQDFKKMVNCAPEFLKLKHCLEKTIEVVISALKGC--SGDVNLLQ-NCVESI
CNLASDFYRDLSVP---STSVDSYEGR--VTHVVHKELESLAKSLLFCFQSEDGPDLLKP
WETYNQNTEE-EH-QQSKSSVIDGSKNKGVPKHVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSMYNTTFIQNRNDTLGLS-SQNNSSLIALTQSSRLKQPMKLEMPECEND-PLLKSLSKI
KEVNRTYVISACKKVQDAPFAPNSEGKLTLQRRTRK-IQEPPLLSSQL-----QEETT--
---TTTLQCRITMDSLEKCKTNKNV----------------------PDGT--VRSALEQ
SNKNVKTANTDKHSLAKSVSPVVED--IKQRKITIDEKNKEKCSAL--SAEDGNLLRDRC
SVFQS-VESQSQNEVSRLGHSAVTKPIRNISDIKIITTGNLSNKSVGKETMKNLNNKFGS
VEK-------------------------------------------------PKTPRQWV
MEENKFTPKSNTPQEKITTLS-IPKNRTCLQIMQKQKST--PSSFL-ENKRERSQENL--
----I--EEETIIQN-TYRQSNLLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSSXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-X---------XXXXXXXXXXXXXXXXXXXXXXXXXXLE--SAF
EGYNTCLFAYGQTGSGKSYTMMGFGE-EQGIIPRFCEDLFSQVAKK-ETQE-SYHLEMSF
FEIYNEKIHDLLVCKAN---GQQPLRV-REHPISGPFVEALSVNVVSSYSDVQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEEEEHDHRIISRINLIDLAGSERCSA
TQTSGERLKEGVSINK-SLLTLGKVISALSEQT-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPADSNI-EETL---STL-RYAKQAGLIINIAKVNEDVNAKLIRXXXXX
X--XXXXXXXXXXXXXXXXXXXXCQQEITSLRMKLHQQEKEIAEM---QRAWREKLEQAE
KRKLQETKELQKAGITFKMDNRLPNLVNLNEDPQLSEMLLYMLKEGKTTVGKYKPNSGHD
IQLSGVLIADDHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXKGKIS----FVCLTNDGPKDFEFAKNELLMAQRSQLEAE--EERLKAKEEMM
RGIQIAKEMXXXXXXXXXXXXXXXXXXXXXXXKEESERKKMQEINNQKANDKIQELEKAK
QHLEQKVHVNKKRLEMETLATKQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXQPNWNFMKLSVMIQEANTISNKLRKCYVFCRHDISSQGNSPEPFVQVQVRNVQL
GISTFWSLEKFESKLAAMKELYEXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXLMEKSDNIYSNSAESFLPGICKELIGS
ALDFLSQSDDEEKTMADSLIASFLKIHSCMTAISKAYEQQDEES---QDNFFSTDRAIQS
FCIQMTSAFEHLVILTKHCLDDFPQST---SGPDDDLTQEVKKLGGYLQLFLQXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVIEKMKSNAVALIRSFGNTIADWKKKDFRV
QVKEEESVCQDAETLINLATEFLKLKHCLEQMSQIVISAMKGS--SSDV-L-LKNCVKDI
CNLSRHFIGNFSLFATLSDLTNTYDDR--ISDAASRELQSLAKSLLLDFESGEIFDLLKP
EEVSEQNSKDEEK---HKLTGTESTTSKGVPKRVYKLQ--APSSTLCTGELSPSNI----
--QWV------

MSVYTTHSRNN-RDILGIPSSQKSSSLNVLTHSSRRKLHLNSDMSECENDDPFLRSASKI
RDINCTYVISACKKTGEVPLTPDPVGRLTLQRRVTR-NKESSSHGSEL-----GDSTEKT
AETRLTLQRRAKTGSVGKWRTTQTDSVEKGKTAQTDCVKKWKTTQNVGSPTENDCASLEV
RRKV-TVVNNDKDSSVAPFVPLAEG--PKDVEMMNDEKHKETSS-ALLG-ANEHVALQYL
SNRAP-TDTQSQTKVVPSRHL-ATKPLQSKLSIKVSGTGNLHQRSTGKDMAKNS-NKFES
LEK--------------------------------------------------RTPTKYI
I-GHKWTPKCGTPQLMSPAAS-TPKNRVS--GLQVQQKP--RGSLL-ANERERSQENT--
----LPLEEETAGRN-TSIEADPLKVENSQVTVAI

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKVEKASQVVFMNGEEI
V-VEHPDMKQVYNFIYDL---------TFWSFDECHPNYASQTTVYEMLAVPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGLSE-EPGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVSGPYVEALSMNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTESVEGEEHDHRIMSRINLIDLAGSERCST
AQTSGDRLKEGGSINK-SLLVLGKVISALSEQA-NRKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATVSPAANNI-EETL---STL-RYASQARMIVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDIAEM---QRAWKEKFEQAE
RRKLQETKALQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFDGIVSIIPVGEAKTYINGKHILESTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TLISEGPKDFEFAKNELLIAQRSQLEAEIKEAQLRAKEEMM
QGIQIAKKMAQQELSSQKAAYESKIKTLEAELKEEAQRKKMQEINNQKANDKIEELEKAK
QQLEQEIYVNKKRLEMETLAAKQALEDHSIRHARILEALETEKQKIAKEVQILQQNQSNR
DKTFLIQTNWSSMKLSMMIQEANAISHKFKKCYVFSRHDVSDKGSNSDTY--VRVRNLQL
GISTFWSLEKFESKLAAMKELYESNNNNKS-DDVFCDPEDEWEPDITNAPVSSFSRR-RS
RSLMKNRRISGCLHDIQAHPIQDLHSSH--SSGLLEKSSPIYSSLAESFLPGICKELIGS
SLSFLGQSYDEEKTMADSLMDNFLKIYHGLFAISKAHEEQDEES---QENLFSSDRTTQS
LTIQVTCAFEQLVVLIKHWLNEILPCI-STARLEDELRQEIKKLGGYIQLFLQGCCSDIS
SMVKEAQTKIIRIVQQAVKYVGQLAVLKGSKLHFLENSSNKAAGIQEDFMDALCDGVGLG
MKILLDSGLEKAKELQHEL---LSQCTQNEVTKQMKGKAMGLIGCLENMFAEWKTKSFRT
ELQQEGPGYQDLKKTINLAQEFLKLKHCLEQTIQIIISALRGC--HMDKNILK-NCVESL
CNLAKDFHDDLSMC---STSLDSCEKR--LPRVGHGGLESLAKSLLLCFESEERADLLNP
WETCNQNTRE-EG-RQSKSSRTDSIRNKGVPKRVFELH--GSSPAVTSEDSMPSRI----
--QWV------

MPDYKVPARNP-SETQCTTTSQRISSRSAFTSSKMSGQQLTSQMSGKEKDGLLSSSRNRT
EEVNSTYVISACNNANDASVTLKPQDRLTLQRRTRV-SKNLVSSSEQSDNKIRQSIENTQ
TGKRCTLQRRVRTGSVEKSKINWNAVPGIENND-FAAERNYK------------------
-TALRPNINNNDTRHGNPSCKLAEG--QSNTKMHFNLNSKDLFGNV------ENDKRTPV
KRKTSTADSKLQNEAHISEQLVTSKNINRISGEQLNEKGDVN-KLEEKQRLQHLMIKHNS
LER-------------------------------------------------PRIPTKGS
TEGFMLTPKNSTFQDKSSLSA-LNKRPL-HPPLVSKKKTG-VSSCP----VSI-------
---SAKEKVETLTEN-NSTEEDIFKVENSKVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSNREKNENSLPVVSMSGSET
A-VRNPSTNQVYTFSYDF---------SFWSFDKCHPNFASQAMIYKTLALPLLER--AF
EGYNACLFAYGQTGTGKSYTMMGFDE-DRGIIPRLCEDLFSQMDKQQVKDLVLYHLEMSY
FEVYNEKIHDLLVFKAENRQKKQPLRV-REHPVLGPYVEDLTVNVVSSYSDIQ-SWLELG
NKQRATAATVMNDKSSRSHSVFTLVMTQTKVESVDEQQRDRSLTSHINLIDLAGSECCST
AQTTGERLKEGVSINK-SLLTLGKVISALSKQSQNGKKTFIPYRESVLTWLLK---ESLG
GNSQTAMIATISPAASST-EETL---STL-RYAKQACSIINTAKVNEDVNAKLIRE--LK
AEIEKLKA-QKSAQNTDPEKYRRYLQEITSLRMKLHQQERDTAEMQSILRAWKEKLEQAE
KRKLEDIKELQKAGIAFKMDNHLPNLVNLSEDPQLSEVLLYMIKEGE

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGRYTPNSKHD
IQLSGVLIADDHCVIKNNLGQVSIIPRREAKTYVNGKCILDPTVLHHGDRVIL

ENSGT00890000139327_5_Linker_3_4 (1014, 1174)

GGDHYFR
FNHPVEVQKVKRPSCGT--TLLHDGPKDFEFAKNELLIAQKTQLESEIEEARLKAKEEMM
QSVQIAKEMIQQELTSQKEAYESKIKSLEAEVREESRKKQMQELKNQKAATKIQELEKAK
QNLELELHFNKKRLEVETLATKQALEDHSIHHA

PF01271 // ENSGT00890000139327_5_Domain_4 (1174, 1196)

KILQALEAEKQKIAEEIQTLQKNRGSG
NKTMTIPLNWNSLKLSVMIKEANTISNELGKNTVFCRHDKVDDKTGTVSSIQVQVRNIKL
GIATFWSLEKFECKLAAMKELYESNDNNKA-ADVFYDPADEWEPDLSDASVSSLS-RRRS
RSLMKNKRISRCLSGIKLEPTHDTQTSY--ISGSQSK-SSICPNFSESLLPGICKESVSS
ALDLLEQNHEGRKSIADHLLRNLFTIFSGVSAISKAYEQQDEEC---QKNFFSTDPAAQS
YSIKITSVFGQLVVLVKVWLNHVQKSP-SSVKTDEELKQEVKNLGGYLQLLLQGCSSDIS
SMVTEAQSKVNEAVKQTIKCIGHLAVFTRTDISIFEENDIPATSLQKDFVLAVYDGVGLG
LDFLTETVQEKARTVQEEL---LKQHPQNEIQNRIRDDAVALARFLENNISSCRKKEVES
QLPEEDYVYMEIKRSTKIAVKYLELEQCLTEVYQIVSSTLQGS--FRNTSPLR-SFAGEI
CFIAGCLYNYFSSFPLASTSTNNPIQRTPMPFMNLDELDSLVDSLIVNFELDQGQQNLKS
QPLCNETTETSQP-LCNETETEGSQKLKGIPKHTYKLQ----SPPTFPEELSLGKI----
--QWV------

MPIYKVPNISH-IRTLSSSSQQHL-PENAYI-RDRFGEQPTPDVSENERENSLSQSLNKT
KERNRTYVLSACNMLASASPALKNGGKLTLQRRTAT-SKEQSSI------NATCDGENTQ
TEKKLTLQCRQRIGSTEIPKTNNANEARRGNTA-LLSQKNNT------------------
-TLFPAKRNSNDPPLVKTGPQSLTP--CRDVKLNPSMKNNVSLDQI--GSNSY-RSYTPL
KHRTVSTE---SENVPRSSLLFPAKS-DTTSAVKSMGEKNFC-KETGIVNVQDGNPKNKN
VER-------------------------------------------------LKTPRKGM
TDGPKFTPKCMPVQHAQTSTI-S--------TVRNKTLCSETTSYAQSIKNGRVQENTRS
IQQMFVLQDDTPKQD-TCIKDDPFKIENSKVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 816)

RVRPFSGRERNEERFQIISMAGQET
V-VNHPNTKQTYSFSFDF---------SFWSFDK-SPNFAGQEMVYRSLAIPLLER--AF
EGYNTCLFAYGQTGSGKSYTMMGFDNDERGIIPRFCEDLFKRIEEA-ETQQIAYHLEMSY
FEVYNEKIHDLLIFRRETGQKKDPLRV-REHPVFGPYVEDLTVNVVTSYSDIQ-SWLQLG
NKHRATAATGMNDKSSRSHSVFTLVMTQTKTDIVEKEEHEHRIISRVNLVDLAGSERCSA
ARTSGERLKEGVSINK-SLLTLGKVISALSEQNQNKKKVFIPYRESVLTWLLK---ESLG
GNSKTTMIATVSPAARNV-EETL---STL-RYAQQACYIVNIAKVNEDINAKLIQD--LK
AEIEKLKLAQKNLQNIDPEKQRVYVQEITSLRMKLHHQEKEMAEM---QRAWKEKLEQAE
KKKFEETMELQKAGITFKVDNSLPNLVNLNEDPQLSEMLLYMIKEGQ

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

TTVGRCKPNSRHD
IQLSGILIADDHCIIKHVDGAVSIIPLEDAKTYVNGKCILGPINLHHGDRIILGGDHYFR
FNHPVEVQKTKSQSCGV--GLHEDGQKGFEFAKNELLAAQRAQLESEIEEARVKAKEEMI
QGIQIAKEMAQEELCSQQKNYESRIKSLEAQLKEESHRKQLQEMNNQMTANKIQELEKAK
RGLELEVHFNKKRLEMETLAAKEVLEDHTIRHAKILEALEAEKQKIAQEVQTLQQNRGNR
KK----EPNWNSLKLSMMIKEANVISSKLKNHTVFRRHDATDKENGTGPC--VQVRNIKL
GVTTFWSMEKFEDKLAAMKEVYETNSTNKS-DEIFNDPTDDWEPDILNASVSSVSTKSRS
RSLRKSKRISVCLSEVKMR----LDSSY--LPGSTNKLTSLSSDAPESFLPTICKELIGS
ALNVFEPTDEEEESIAQSLLETMFTIHTGVIALTKAYEQDEDS----QENFFVTDQAAQS
CSIMIVSAFKQIILLTKHWGNCFRKNE-EFVNIYDEMREDVKHLGGYLQLLFQGSSSDLP
LMVAEAQKKIKETLREMVNYIGHLAALSGCGLHFGVENNREARDAKKLFMSDICDGMDAG
LSYILDCILKTSRIMQKEL---LKWYPQNEVQNYIKEKAVAFAKFLEDIISDCKKREITN
LLRREESIDQELKKALKRAVEFLELHHCLDQVYQMVTSSLQAS--YRNGNPLR-YFVEKI
CHLAGNFNTFCIQPALATDSADKPFQRISELLVNQRELDSVAKSLIISFELEHRQDVLKL
QDGCVPHVQLDGK-QLKRSDATDFWEEKKMPKCELW------SVPKSLGPSSPSAI----
--HWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENYDPLLRSAGKV
RDINSTYVISASEKTADMPLTPNPVGKLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLTLQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-KIVNNAKNSFVASCVPLDKD--PQVIEMMADKKYKEIFS-APSR-ANENIALKYS
SNRAP-IASLSHTEVVRSGHL-TTKPTQSKLDIKASGTGNLHHRTIGKEIAKTS-NTFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NFQVKQRP--KSSFL-ANKQESSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHIIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYGEERTIADSLMNSFLKIYNGLFAISKAHEEPDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASIQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKKMANHAPEFLKLKHCLENYY---------F--LSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSPEECTPSRI----
--QWV------

MSLHSTHNRNNSSDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLSRSAGKV
RDINRTYVISVSKKTADMPLTPNPVGRLALQRRTTR-NKESSLLGSEL-----EDTAEKI
AETRLTLQRRAKTDYAEKWKTAETD-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFDASSVPLDED--PQVIEMMADKRYKETFS-APSR-ANENVALKYS
SNRAP-AASLSQTEVVRSGHL-TTKPTQSKLDIKVLGTGDLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
L-EHKLTPKCGLPQVKSPAPS-ILKKRMS--NLQVKQRP--KSSCL-ANKQERSAENT--
----ILPEEETVVQN-ISAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQIYNFIYDI---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVAGK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNIVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQRRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRAWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPTSEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWNLEKFESKLAAMKELYESNGSNGG-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQVVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---FRQCTKNEVTKEMKTNAMGLIRSLENIFAELKIKSFRR
QVQEENFEHQDFKKMVNHAPEFLKLKHCLEKAIEIIISALKGY--SSDENLLQ-TCVESI
RNLASDFYSDFSVP---STSVDGYESK--VTHVVHQELESLAKSLLFCFESEESPDLLKP
WETYNQNTKG-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSMYGTTIIRNRNDGLGLS-SQSNS-----SQSSRLKHHMKSEMPECENN-SLFKSLSKI
KEINKTYVISACKKVQDEPLTPNLEGRLALQRRTRK-IQEPPLLGSQL-----QEETEET
T-EQLTLQRRIRLDSLEKCKTNKNA----------------------PDIIDNKKSALDQ
SNKNLKTANSDKHSFVKSISPVFEN--IERRKTTADEKSKEKCSLP--NAENGNILHDKC
SVSQV-FESQSQNEVSRLGHSTVMKPIQNTSDIKIITTGNLNNRSTGKETMKNINNKFGS
LEK-------------------------------------------------PRTSRQCI
MEENKFTPKWSTPQGRTSALS-ISKSRTCFQNMQNQKSV--PSSFL-ENKRERSQEKT--
----LLKEE-TIIYN-TFRQSNLLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSSREKTEKASQVVFMNGQET
T-VQYPDMKQIYNFIYDF---------SFWSFDKSHSNYASQMTVYETLAVPLLES--AF
EGYNTCLFAYGQTGSGKSYTMMGFGE-EVGIIPRFCKDLFSQVAKK-ETQEVSYHLEMSF
FEIYNEKIHDLLVCKGENGQKKQPLRV-REHPVSGPYVEALSVNVVSSYSDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEEEEHDHRIISRINLIDLAGSERCSA
TQTSGERLKEGVSINK-SLLTLGKVISALSEQA-SRKRIFIPYRESVLTWLLK---ESLG
GNSKTAMIATVSPAASNI-EETL---STL-RYAKQARLIINIAKVNEDVNAKLIRE--LK
AEIEKLKATQRNTRNIDPERYRRCQQEITSLRMKLHQQEKDIVEM---QRAWREKLEQAE
KRKLQETKELQKAGITFKMDNSLPNLVNLNEDPQLSEMLLYMIKEGKT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKNKPNSGHD
IQLSGVLIADDHCVIENFDGTVSIIPLGDAKTYVNGKHISESTILHHGDRVILGGDHYFR
FNHPVEVQKGKISFCGS--VLTNDGPKDFEFAKNELLMAQRSQLEAEIEEARLKAKEEMM
QGIQIAKEMAQQELSSQRTAYESKIKALEMELKEESERKKMQEINNQKANDKIQELEKAK
QHLEQKVHVNKKRLEMETLATKQALEDHTVRHAKILEALEAEKQKIVKEVQILQQNRNNK
DKMLTIQPNWNFMKLSMMIQEANTISNKLRKCYVFCRHDISSKGNSTEPSVQVQVRNVQL
GISTFWSLEKFESKLAAMKELYESNSGIKG-EDIFYDPVDEWEPDLANTTVSSFSRR-RS
KSLMKNRRISGCLQDIKVHPIKNLNSSH--SSGLMEKSSSIYSNSTESFLPGICKDLIGS
ALDFLSQSDDEEKTMVDSLITNFLKIHACVISISKAYEQQDEES---QDNFFSTDRVIQS
FCIQMTSAFEQLVVLTKHWLDDFPQSI---SRPDDDLTQEVKKLGGYLQLFLQGCCSDIS
SMVNEAQKKMIQTMLQAVKYVGQLAILKGTKLHLSENSRDEMVYLQEDFINAICDGVSLG
MNILLDSGLEKMKQLQQEL---LGQCPQNKVIEKMKTNAMALIRSFENTITEWKTKDFRA
QAKEEESVSQDVKKLINLATEFLKLKHCLEQISQIVISALKGLGSYSDVILLK-NCVENI
CNLVRHINDEFILFTPLSGSTNTYDDG--ISGVACRELQSLAKSLLLDFESEERFDLLKP
KEICKQNSEDEEK---HNLTGNKYTSSKGVPKQIHKLQ--TPSSTHCTGEFSPTNI----
--QWV------

MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV
RDINRTYVISASKKTADMPLTPNPVGRLALQRRTTR-NKESSLLVSEL-----EDTTEKT
AETRLTLQRRAKTDSAEKWKTAEID-----------SV---KMTLNVGGETENNGVSKES
RTNV-RIVNNAKNSFVASSVPLDED--PQVIEMMADKKYKETFS-APNR-ANQNVALKYS
SNRPP-IASLSQTEVVRSGHL-TTKPTQSKLDIKVLGTGNLYHRSIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCSLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSLL-ANKQERSAENT--
----ILPEEQTVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYNFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNIVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTNGDRLKEGVSINK-SLLTLGKVVSALSEQA-NQRSVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFFGQSYDEERTIADSLINSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAAGVQEEFMDAVCDGVGLG
MKILLDSGLEKAKELQHEL---FRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVQEENFEYQDFKRMVNRAPEFLKLKHCLEKAIEIIISALKGC--HSDINLLQ-TCVESI
CNLANDFYSDFSVP---STSVGSYESR--VTHIVHQELESLAKSLLFCFESEESPDLLKP
WETYNQNTKE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSLHSTHNRNNRGDILDIPSSQNSSSLNALTHSSRLKLHLKSGMSECENDDPLLRSAGKV
RDINSTYVISASEKTANMPLTPNPVGRLTLQRRTTR-NKESSLLGRDL-----EDTTEKT
AETHLALQRRAKTDSEEKWKTAETD-----------SV---KMTLNVGGETENNGVSKER
RTNV-RIVNNAKNSFVASCVPLDED--PQVIEMMTDKKYKETFS-APSR-ANENIALKYS
SNRAP-IASLSQTEVVRSGHL-TMKPTQSKLDIKVSGTGNLHHRTIGKEIAKTS-NKFGS
LEK--------------------------------------------------RTPTKCT
T-EHKLTPKCGLPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSFL-ANKQERSAENT--
----ILPEEETVVQN-TSAGKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTKREKIEKASQVVFMSGKEI
T-VEHPDMKQVYSFIYDV---------SFWSFDECHPHYASQTTVYEKLAAPLLER--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVAGK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKDENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYTDIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCST
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNI-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIAKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFEQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTITNLGGTVSIIPLGEAKTYVNGKHILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--TPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMM
QGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELQKAK
QHLEQEIYVNKKRLEMEALATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSS-SDTS--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRD-EDVFCDPEDEWEPDITDAPVSSLSRR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSSTIYSNSAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLFAISKAHEEQDEES---QDNLFSSDRAIQS
LTIQTACAFEQLVVLMKHWLSDILPCTTNIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVQQAVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAICDGVGLG
MKILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRR
QVKEENFEYQDFKKMANRAPEFLKLKHCLEKAIEIIISALKGC--SSDVNLLQ-NCVESI
RNLASDFYSDFGVP---STSVDSYESR--VTNVVHKELESLAKSLLFCFESEESPDLLKP
WETYNQNTEE-EH-QQSKSSGIDGSKNKGVPKRVYELH--GSFPAVSPEECTPSRI----
--QWV------

MSVHAELST--NSDPVGAPASPESSSRHVLGHSSGLQLHSKLEMSECENDDLSLRSASHV
RDINLTYVISACRKAGDAHLTPNSSGRLTLQRRVTR-NRESPLLGNEL-----GASAEKR
SGTRLTLQCRAGTGRVDEWG----------------------AAQRVKGAAGGDRASGET
SANV--QVVDDKQSLVASSAPSAED--LKVAEMTAEEKYKETLSAL--SGPNDNVALKCL
SHRVP-VGPQSQTGLVRAGYW-AARPVQSPLDGRESGTGKSHPRSIGKNAAKNS-SKFES
LEKRAPSRCAAERTSTPRRAPH--------------------------------------
--------------LPSPATP-VPRSGVP--SPQVRHEP--TRSLL-ANKRERSREGT--
----APPQEEAAAQT-SSADREPLEAESSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 820)

RVRPFSKRETVENAAQVVFMDGGAI
A-VRHPDTKHVYSFTYDL---------ALWSFDAGHPGYASQAAVYEALAAPLLAR--AF
QGYNTSLFAYGQTGSGKSYTMMGYGE-EPGIIPRFCEDLFARVAKK-HTQEVSCHLEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPASGPYVEALSANVVSSYSDIQ-SWLELG
SKQRATAATGVNDKSSRSHSVLTLVLTQTKTEFVAGEEHDHRVTSRTNLVDLAGSERCGS
AQTSGEQLKEGVSINK-SLLTLGKVISALSEHV-DRKRVFIPYRESVLTWLLK---ESLG
GNSRTAMVATISPAAGSV-EETL---STL-RYAQQARAIVNVARVNEDGSAALVRE--LK
AEIEKLKAAQRSRQNIDPERYRLCQQEITSLRMKLHQRERDMAEM---QRVWKEKFEQAE
RRKLQEIKELQKAGITFQVDNRLPNLVNLTEDPQLSEMLLYVIKEGT

PF00498 // ENSGT00890000139327_5_Domain_3 (948, 1014)

STVGKCHPGSSHD
IQLSGVLVAEDHCTIRNFDGTVSVVPVGDAKTYVNGRHISEPTVLHHGDRLVLGGEHYFR
FNHPAEVQSGKRPAG--------EGPKDFEFAKNELLVAQRSQLEAEVREAQLRAREETL
RGIRVAEEMARRELSSQKAAYESRIGALEAELKEESQRKKLQEISNQKANDRIEELEEAK
RQLEQEVRVGRTRLHVEALAARQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-XXXX--XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXS
RSLAKNRRISGCLRDVQAHPIQNSHSSC--SWGSAGTSGALCPGAADPVLPGICRELIGS
SAAALARGCGAE-SAADSLLGGFLRVYAGLHAVSRAHEDQDEDS---PDDLFS-DREAQA
HTVRLACAFGQLVVLAAHWPRGVGPAT-GAASLGDELGEAITKLGSHLQLFLQGCCADIP
AMVADAQQNVLRTVRRAVRCVGQLAVLQGSALRFLDDGGSKAAGAPERFAAALWDGVGSG
LRLLLDSGTDAAERLQREL---RGQHAPDEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRRSDPQLLG-DCVESL
CSLARDFRDDVSVP---HAPRDSCA-------KSCRDLESAARSLLFCLGTDGGPGLLTP
KSPGGWR--------RSMSGRAGHAGDTGVSRCGYTLPP---APGS--------------
-----------

MSLHTTYNRNNSGDILDIPPSQNSSSLNTHTHSSRLKLHLKSDMSECENDDLLLRSVGKV
RDINSTYIISASKKTGDVTLTPNPVGRLSLRRRTTR-NKESSLLASEL-----EDTTEKT
SETCLALQR-AQTDSAEKWKTAETD-----------SVKKWQMTANVGGKIGSNCVSKES
RTNV-KIVNNAKNSFVASSVPLDEDSDSKVIEIMANKKYKETFS-APSR-AKENVVLKYS
RNRTP-IASLSQTEVVRSGHL-AMKPTQSKLDIKVSGTGNLYHRSIGKETAKTS-NKFGS
LEK--------------------------------------------------RTPTKCI
T-EHKLTPKCSTPQLKSPAPS-ILKNRMS--NLQVKQRP--KSSLL-ANKQERSAENT--
----ILPEEETAGQN-TSADKDPLKVENSQVTVAV

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFTMREKIEKASQVVFMNGKEL
T-VEHPDMKQVYNFTYDV---------SFWSFDECHPHYACQTTVYEKLAAPLLGR--AF
EGFNTCLFAYGQTGSGKSYTMMGFSE-EPGIIPRFCEDLFSQVARK-QTQEVSYHIEMSF
FEVYNEKIHDLLVCKGENGQRKQPLRV-REHPVYGPYVEALSMNVVSSYADIQ-SWLELG
NKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRINLIDLAGSERCSA
AHTSGDRLKEGVSINK-SLLTLGKVISALSEQA-NQKRVFIPYRESVLTWLLK---ESLG
GNSKTAMIATISPAASNV-EETL---STL-RYANQARL

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNIAKVNEDMNAKLIRE--LK
AEIEKLKAAQRNNRNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRVWKEKFDQAE
KRKLQETKELQKAGITFQMDNHLPNLVNLNEDPQLSEMLLYMIKE

ENSGT00890000139327_5_Linker_2_3 (946, 949)

GTT

PF00498 // ENSGT00890000139327_5_Domain_3 (949, 1014)

TVGKYKPNSSHD
IQLSGVLIADDHCTIKNFGGTVSIIPVGEAKTYINGKRILELTVLHHGDRVILGGDHYFR
FNHPVEVQKGKRPSGRD--PVISEGPKDFEFAKNELLMAQRSELEAEMKEAQLKAKEEMM
QGIQIAKEMARQELASQRAVYETKINALEAELREESQRKKMQEINNQKANHKIEELEKAK
QHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRSNR
DKTFTMQTTWSSLKLSVMIQEANAISSKLKTYYVFGRHDVSDKSS-SDTF--IRVRNLKL
GISTFWSLEKFESKLAAMKELYESNGSNRG-EDVFCDPEDEWEPDITDAAVSSLSKR-RS
RSLMKNRRISGCLHDIQVHPIKNLHSSH--SSGLMDKSNTIYSNLAESFLPGICKELIGS
SLDFLGQSYDEERTIADSLMNSFLKIYNGLLAIAKAHEEQDEES---QDNLFSSDRATQA
LTIQTACAFEQLVVLMKHWLSDLLPCT-NIARLEDELRQEVKKLGGYLQLFLQGCCSDIS
SMIKEAQKNAIQIVHQAVKYVGQLAVLKGSKLHFLENSNNKTASVQEEFMDAICDGVGLG
VEILLDSGLEKAKELQHEL---LRQCTKNEVTKEMKTSAMGLIRSLENIFAESKIKSFRR
QVQEEHFGYQDFKKMVNCAPEFLKLQHCLEKTIEVVISALKGC--SGDVNLLQ-NCVESI
CNLASDFYRDLSVP---STSVDSHEGR--VTHVVHKELESLAKSLLFCFESEDRPDLLKP
WETYHQNTEE-EN-QQSKSSGIDGSKNKGVPKHVYELH--GSSPAVSSEECTPSRI----
--QWV------

MSVYTAHNTRSDSTLLGAPS-SRSSSLRVLTAGSRRKLHSTSDVSNCENDDPLSRSTSKI
RDINRTYVISACKKAEDRPLSPDPEGKLTLQRRVTR-CKEPAPLGSEL-----GDTAEKT
AETSLALLQRTQTDSSEK----------------------WKTAQSVGEKLCSARS----
RCRC-KDVNNDQSFFAVPSAPLPVN--PNGIDVKADEKYKETLSTR--RGAGGNRALKSL
TDRGP-VGPRSQMAVAGSGCL-AAKLFPARWTSEP---------------RTRK-LTSQN
LEK--------------------------------------------------RAPSKCN
T-EPRLAPKRGVPQPESPATW-VLKSRVP--RLQVQHTP--QSPLL-ASKRERLQEKT--
----FLLEGETTLQK-TFAETDPLKVENCQVTVAI

PF00225 // ENSGT00890000139327_5_Domain_0 (456, 819)

RVRPFSKREKSAEEPQVVFTNGKEV
A-VEHPGKRQVHTFTYDL---------SFWSVDERHPSFASQAAVYQALAAPLLEQ--AF
GGFNTCLFAYGQTGSGKSYTMMGFNE-EAGIIPRFCEDLFAQVAKK-QTQEVSYHLEMSY
FEVYNEKIHDLLVCKGENGQRKPTLRV-REHPASGPYVEGLSTGGPRA--LWG-IWLELG
NKQKATAATGMNDKSSRSHTVLTLMMTQTKTEFVEGEELDHRIRSRINLVDLAGSERCWA
TQSSGERLREGVSINK-SLLTLGKVVSALSEQA-GGKRAFIPYRESVLTWLLK---ESLS
GNSKTSMVATVSPAASSVEETL----STL-RYAAQART

ENSGT00890000139327_5_Linker_0_2 (819, 874)

IVNVAKVNEDMSAKLIRE--LK
AEIEKLKAARRNSQNIDPERYRLCRQEITSLRM

PF16183 // ENSGT00890000139327_5_Domain_2 (874, 946)

KLHQQERDMAEM---QRMWKEKLEQAE
QRKLQVTKELQKAGITLQMDNRLPNLVNLSEDPQLSEILLYVIKEGATTVGKDKPDSRHD
IRLSGVLIADHHWYA---APLVTVTPAGEAKTYVNGKLISQPTVLHHGDRLILGGDHYFR
FNHPVEVQRGERPSSRH--ALMSQGPRDFECAKNDLLSAQRLHLEAEIKEAQLKAKEEMM
QGIQIVREMAQQELSSQKAAYESKIKVLEAELKEESQRKKMQEINNQKANHKIEELEKAK
QRFEQEIYVNKKRLEMEALATKQALEDHRIRHAKILEALEIEKQRIAKEVQLLQQNQSNR
DKTLTIQPNWSCMKLSLMIQEANAISNKLKKNYVFGRHEVGDKGSSSDTY--IQVRNLQL
GISTVWSLEKFESKLAAMKELYESHGDNRT-DDAFCDPEDEWEPDITNVPASSFSRR-RS
RSLMKNRRVSGCLQGLEARSAQDLRS------------------SAESFLPGVCKELIGS
SLELLGQSYDEENTMADSLIRNFLKIHDGVLAISKAHGEQDEDG---PCNLFS-DRANQY
LAVQVASAFEQLAVLVTHWLSGVLPGA-GPEGLPDELRQEVRNLGACLQVFLQGCSSDIS
SMVTEAQVQVTRMVRRAVGHVGQLAALAGAELRLLGSSTGGVAGLQDDFAAALCDGVGLG
ITSLLDAGLEKAKELQDEL---LGQSPQNEVARQMETNALGLIGSFENLCAEWKTKSCQT
QVQEDDSGCRDLKKMVNLAPEFLKLKRCLEQTIQIVISTLKGR--PADVPLLK-DCVESL
RSSARGLRGDQSTGS---------EG-----HGELESLESRAASLLLGFELVERPGVLEP
RAACGQDPRAEGH-EQ-QGSRPGPRRDRGVPKRVYELQ--GPVPGGSGQGRPREDVPAGP
GGQWGAV----