Query Results 

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLLDSPE---------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDEALIDPNILSLNIL
SSGYVHPAQDDRQFLDSDIP--------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEVLSPASSEDSES
RSSSGASSPLSAEGQPS----PLEVPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPVRAT-ETEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTSNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAVSGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EE---------------EEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KTALDGHLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIRPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEVLSPASSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTSLRDPPMSPLGPATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPAQAT-ETDKEPPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVE-RFVLNL---ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKVSLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTGTVP-----------------------------------------GGPRLTSALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAEKRQDIVLSGHFIKEEHCVFRSDSCGGSEAVVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSIIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SSVVSGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
---E------EEEEEEEEEEEEDLQDDVFPEHVLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQAESCPGVGMS-RSGTSQEELRIVE-GQGQAADSGPSA
DEVNNNTCSA-AVTPEGLLDSPE--------------------------KAALDGPLDAA
LDHLGLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPLVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKPGPPVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLSIL
SSGYICPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLEAAQRPGPETLSPAASDGSEA
HGSSSASSPLTAEARPA----SLEAPSERQRELAVKCLRLL-THSFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
PLPE-VDAKKLPSPARAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNHDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------K----------------------
-------------DSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDMRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEELEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EE-----------EEEEEEEEEDLEDDVFPERALCNG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VSPDGLLLDSPE--------------------------KAVLDGPLDAT
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKL-------------------------------

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPVSSEDSES
RSSSGASSPLSAEGRPS----PLDVPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADARTPQPCSRPSSPEPE
LMPE-ADSKKLPSPVRVA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYSSDKDPVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MGLSAGVEGGHW------------------PV
GSEQGWGREQPGGVLAGPPGAQGGALGSAPGGRALTWEQGQPLPARAPKLGLWGAPWQAP
PLAPPSPCGVDPLSA--SPPQNK

PF00225 // ENSGT00890000139327_0_Domain_3 (384, 442)

KKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNAVP-----------------------------------------GGPKLTNALVAVS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEEEPEDEGEWAWAA-----------S--WGA-----HTPAVLRDPEAGAG-
---LPHGGLMRPPPQVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_11 (1089, 1543)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDVTEPA--EEQ------
-----------------SAGEEDLEDDVFAEHALCGG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTARISFDDQHFEKFQSESCPGGGLS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-LPPEGLLLDSPE--------------------------KAALDGPLDAA
LEHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPSPGPCRCKYELLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_11 (1543, 1631)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIPPTQDDRQFLDSDMPSPSLPSFTPSLVNLFTLFSHSFTPSLLCSLVTPSLPN--Y
LTPSLLHSFTPSVLHSLTPSCPPSFAHSLNRLFPW-LRQAAL-----RRGFQWCGRRRA-
-----SEHGRVFSVE-KAFLRCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEVLSPASSEDSDS
RSSSGASSPLSAEGRPS----PLEAPSERQRELAVKCLRLL-THTFNREYTHSHVCGSAS
-ESKLSEMSVTLLRDPSMSPVGAATLTPSSTCPSLVEGRYNAADLRTPQPCSRPASPEPE
RAPE--DARKPPSPARAP-EADKEPQRLLVPDIQEVRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDRDAVERFVLNL----STAQVEYSEDQQAMLK-TPHTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRF---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTSNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGSN--K--KKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAVSGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEE---------------EEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAISGACQPEAGQAISDEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KTALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDDSLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEVPSPASSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPPMSPLGPATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-AESKKLPSPAQAT-ETDKEPPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RYVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GVLLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVHWTERECELALWAFRKWKWYQF-------TSLRDQLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCKGYPLLNTCMSQRMATLTPSPTFSSPDSDT-TTEPAEEQSVGEEE
EEE---------------EEEEDLEDDVFREHAQCDG-RDPFYDRPPLFSFVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPGVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGL-LDSPE--------------------------KAALEGPLDST
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAMVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPASSEDSES
RSSSGASSPLSAEGRPS----PLETPNERQRELAVKCLRLL-THTFNREYSHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGTPGVRTPQPCSRPASPEPE
PLSE-ADSRKLPSPALAS-QADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAK
RFVVVRRPYAYMYNSDRDSVERFLLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 428)

RVRPFNSREMSRDSKCIIQMT---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKX
XXXXXXXX--XXXXXXXXXXXXXXX-X----------XXXXXXXXXXXXXXXV---I---
-------SALAKMVSGST--GXXXXXXXXXXXXXXXXXXXXXRENL-GGNSRTAMVAALS
PADINYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXX
XXXXXXXXXXXX---------XXX-----------------------XXXXXXXXXXXXX
XX-XXXXXX---X---------X-X-XXX-XXX-----XX--XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXEALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGITRVGREDGERRQDIVLSGHFIKEE--------------I

PF00498 // ENSGT00890000139327_0_Domain_8 (705, 737)

VTLEPCEGADTYVNGK
KVTEPSILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYCPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKERETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXFQSESCPVEGMS-GSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLLPDSPE--------------------------KAALDGPLDAT
GQHLRLGSSFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXRIRNSPETDESLVDPNILSLNIL
SSGYIHPAQDDRXXXXXXXX--------XXXXXXXXXXX---------XXX-XXXXXXXX
XXXXXXX--------XM-ENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGNLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPQPCSRPSSPEPE
PTLE-AEAKKFPSPARAP-EADKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAR
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKEVPKSFSFDYSYWSHTSPE
DMNYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKVSLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIA
DMT--------------------------------------------------NALVGVS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

TRVGREGAEKRQDIVLSGHFIKEKHCVFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMG
SRGYPEANEEE-EGPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FFKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAE-PSSVIEDCDNVVTGGDPFYDR
FLWFRLV-----------------------------------------------------
----------------------------------------------------GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKXXXXXXXXVGMSPASGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VTPEGLLDS-PE--------------------------KAALDGPLDAA
LDHLGLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPIVFEVXXXXXXXXFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIHWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIYPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYV--------EM-ENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADT-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPGPEALSPISSEDSEA
HS--SSSSPLAAAGRPS----SLEAPNERQRELAVKCLRLL-THSFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRTPQPCSRPASPEPE
PLPE-MDSKKSPSPARAT-EADKEPRRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI---------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GTLTASPSIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYCDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNNNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 615)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
ETNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRME

ENSGT00890000139327_0_Linker_4_7 (615, 640)

SP-----------------------

PF16183 // ENSGT00890000139327_0_Domain_7 (640, 665)

GTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_7_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDTRAGSEAVVTLEPCEGADTYVNGK
KVMEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEELEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRP----------------------------------------------
IVAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSAVEDCENVVTGGDPFYDR
FPWFRLVGSSAVSGCSSYPLLNTCMSERMAALTPSPTSSSPDSDSEATEPAEEQSVGEEE
------------EEEEEEEEEEDLEDDVFLERALCDG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNSCSA-VPPDGLLLDSPE----------------------------------KAT
LDHLHLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEA--------------------
-----------------------------NVRELVVGRIRNTPETDESLIDPNILSLNIL
SSVPLFPAAPDFLPXX-----------------------XXXX

PF12473 // ENSGT00890000139327_0_Domain_13 (1664, 1719)

XSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCMQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_13_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPASSEDSES
RSSSGASSPLSAEGRPS----PLEAPSERQRELTVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGSPDVRTPQPCSRPSSPEPE
LVPE-THSKKPPSPVQAA-ESEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EEE---EEEEEEDLEDDVFPEHTLCDG-QDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLMDSPEK--------------------------V-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDEALIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPVRAT-ETEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EEEEEEEDEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGVATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMGRDSKCIIQMT---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTTPE
DTSYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGRQEKDQQGIIPQLC
EDLFSRISDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNMGKLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETSVTTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENLAGGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYSQGLGDII
DTSTAP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSNTKGSGEVVVTLEPCDGADTYVNGK
KVMEPSVLRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PVEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEEEEPEDEAVQWTEREFDLALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVLEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SSDISGCNSSPLFNTCMSERMADLTPSPTFSNPDSDITEPAD--EQHVG---
----------------KEEEEEDLEEDIFPEYPLYDG-RDPFYDRSPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSEACPVAGMS-RSGTSQEELRIVE-GQGQITDIGPSA
DEVNNNTCAV--TPEELLLDSPE--------------------------KAALDEPLETV
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKPA-AVPATKLSTLARPSAGPCHCKYDLMVFFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCLGT
FLL-HQGIQRRITVTLVHENGSHVRWK--EVRELVVGRIRNTPEGDESLIDPNILSLNIL
SSGYVHPSQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIF
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETSQRPGLESLSPCSSEDSDS
HSTSCVSSPLSADGASEGRSSPLETPSERQKELAVKCLRLL-THTFNREYSHNHVCISAS
-ESKLSEMSVTLLREPSMPALGVTTLTPSSTCPSLVEGRYNATEVRTSLLSSRAESPEPE
PIVE-GEQKKSP--TREP-EEEKETQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTNGWVK
RYVVVRRPYVYIYNTDKDSVERAILNL----SSAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDT--TEPAEEQSVGEEE
E-----------------EEEEDLEDDVFPEHTLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQAESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGL-LDSPE--------------------------KATLDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHSRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFFQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRSLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPCPEALSPASSADSES
RSSSGASSPLSAEGRPS----PLETPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGTTTLTPSSTCPSLIEGRYGSTDIRTPQPCSRPASPEPE
PLPE-VDSKKTPSPARAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMT---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTTPE
DINYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTSTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERMLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCIFRSDSRAGNEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKEREKRPFPRT----------------------------------------------
IVAIEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SSDVSGCNSSPLFNTCMSERMADLPPSPTFSTPDSDITE--PADEQHVGKEE
EEEEEE--------EDEEEEEEDFEEDIFPECSLCDGGRDPFYDRSPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------AKDHNPSI
SSDIRALGQSLLKFHAEWLQXFQSESCPVVGMS-RSGTSQEELRIVE-GQGQVAEIGPSA
DEVNNNTCAA-VTPEDLLLDSPE--------------------------KSIMDSPLESA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPTAGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCLGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SAGYVQPSQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRSGLETLSPCSSEDSES
HSASCVSSPLSD-GTSETRATTLDIPSERQKELAAKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLSAATLTPSSTCPSLVEGRYTAADLRNPPPCSRPVSPELE
PVLE-GEQKKSPSPVGGP-EAEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPKTTGWAK
RFVVVRRPYAYMYNSDKDSVERFILNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQRQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE--------------EEEEDLEDDVFPEHTLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VTPEGLLDSPEK--------------------------T-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVRPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSLASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCVSAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGAADVRTPQPCSRPASPEPE
LLPE-IDSKKTPSPARAT-EADEEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVKEHPLLGPYVEDL
SKLAVTSYNDIQDLVDSWNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRLK----------VGARPP------LGS--------
-----------GLTLNVPPAQNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 724)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KIP

ENSGT00890000139327_0_Linker_8_9 (724, 1042)

IP----QGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
REL-----------------------------------------------KLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1088)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV

ENSGT00890000139327_0_Linker_9_12 (1088, 1544)

GR---------------------------------------------------
------------------------------WHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNVQRASCRGQ------------------RC---PLSPF-PALPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGEH----STDHSLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSES
HGSSSASSPLSAEGRPS----PLEPPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVRCVG-----LPWKAPPSARWCA
DHGA----W----------------------------HLLTSSLPLQ-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTSTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERLLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYSEVNEE-EEEPEDEVPWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEE--------------EEEEEDLEDDVFPEHVLCDC-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGL-LDSPE--------------------------KAALDGPLDAG
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPIPEALSPASSEDSES
HSSSSASSPLSAEGRPS----PLEMPSERQRELAVKCLRLL-THTFNREYSHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADLRAPQPCSRPASPEPQ
LLPE-SDSKKTPSPVRST-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDSVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSWPR---NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
D--------------------------------------------------MTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--ARDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPGVGMA-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VSPEGLLLDSPE--------------------------KAVLDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIRSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ESCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEVLSPVSSEDCES
RSSSGTSSPLSAEGRQS----PLEAPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAPEMRTPQPCSRPASPEPE
PVPE-ADSKKPLSPARAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDATNDNLSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
EGECLCLSWASG---------SGAIDMSDLENNNCNHGRAALHQAPDNLSTVTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGVT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYSEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SS-------HPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EE----------------EEEEDLEDDVFPEHVLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEK--SESCPVVGMS-RSGTSQEELRIVE-GQGQGADMGPSA
DEVNNNTCSA-LPPEGLLLDSPE--------------------------KGALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIRSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPSPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR----------------MTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPASSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAVDLRNPQPCSRPASPEPE
PLPE-ADSKKTPSPVRLT-EVDKEPQRLLVPDIQEIRASSVPGQAGLMAPESGLTMNTGK
GQ---------LSGSEPGSCRDLVVMGLGGTALGQASQVGALPAALS-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----R----------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EEE---EEEEEEDLEDDVFPEHTLCDG-QDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLMDSPEK--------------------------A-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDEALIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPVRAT-ETEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EEE----EEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------

PF12473 // ENSGT00890000139327_0_Domain_13 (1662, 1720)

MHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_13_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEAPSPASSEDLGS
HGSSSPSSPLSAEGRPS----PLETPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRTPQPCSRPASPEPE
PVPE-ADSKKLPSPARAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYLYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_1 (62, 200)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSV

ENSGT00890000139327_0_Linker_1_0 (200, 263)

E----------------------------------------
----------------------

PF00225 // ENSGT00890000139327_0_Domain_0 (263, 294)

TVAATNMNETSSRSHAVFNIIFTQKRHDAET

ENSGT00890000139327_0_Linker_0_2 (294, 297)

NIT

PF00225 // ENSGT00890000139327_0_Domain_2 (297, 442)

TE--
-------------------------------------KEGANINKSLTTLGKV---I---
-------SALAEMVSGPA--RNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
D--------------------------------------------------MTNTLVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEV-----------------------------------------
----------------EFQFVL-VTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDRKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1720)

YIAAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSES
HGSSSASSPLSAEGHPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------GEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEK--SESCPAVGMS-RSGTSQEELRIVE-GQGQISDLGPSA
DEVNNNTCAV-TPE-DLLLDSPE--------------------------KSTMDGPLEAA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPSARMSSGDPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSAGPCQCKYDLMVFFEICELEANGDYIPAVVDHRGGMPCHGT
FLL-HQGIQRRITVTLVHETGSLIRWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIHPSQDDR----------------RTFYQFETAWDSSMHNSLLLNRV-TPYREKIY
ITLSAYI--------EM-ENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGLETLSPCSSEDSES
RSTSCVSSPLSADGAPEGRTSPPETPSERQKELAVKCLRLL-THTFNREYSHSHVCISAS
-ESKLSEMSVTLMRDPSMSALGVTTLTPSSTCPSLVEGRYNTMEVRTPQVSSRVESPDLE
PVVE-GEQKKSPS--RWP-EDEKEPQRQLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTNGWVK
RFVVVRRPYVYIYNSDKDSVERAILNL----SKAQVEYSEDQQAMLKQTPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDMRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKERETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPASVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE------------EEEEEEDLEDDVFPERALCNG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADTGPSA
DEVNNNTCSA-VPPDGLLLDSPE--------------------------KATLEGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDRVSFGI-DT--------RTFFQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SEGNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPDALSPVSSEDSES
RSSSGASSPLSAEGRPS----PLEAPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLDATTLTPSSTCPSLVEGRYGAADVRTPQPCSRPSSPEPE
LVPE-ADCKKLPSPVQAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMT---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTTPE
DINYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQFC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERMLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCIFRSDTRAGNEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKEREKRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SSDVSGCNSSPLFNTCMSERMADLTPSPTFSNPDSDITE--PADEQHVGKEE
EEEEEEEEEEEEEEEEEEEEEEDFEEDIFPECSLCDGGRDPFYDRSPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQVAEIGPSA
DEVNNNTCA--VTPEDLLLDSPE--------------------------KSVMDGPLESA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPTAGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCLGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVQPSQDDRQFLDADMPSISFGNDTRTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRSGLETLSPCSSEDSES
HSTSCVSSPLSD-GTSESRTTTLDIPSERQKELAAKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLSAATLTPSSTCPSLVEGRYTATDLRNPPPCSRPASPELE
PVLE-GDQKKSPSPASGT-EAEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPKTTGWAK
RFVVVRRPYAYMYNNDKDSVERFILNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EE-----EEEEEDLEDDVFPEHTLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VTPEGLLDSPEK--------------------------T-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSLASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-IDSKKTPSPARAT-EVDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

------------------------------------------------------------
---------------------------------

PF00225 // ENSGT00890000139327_0_Domain_0 (94, 443)

IVNPKQPKETPKSFSFDYSYWSHTTPE
DINYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKX
XXXXXXXXXXXXXXXXXXXXXXXXXXX----------X-XXXXXXXXXXXXXX---X---
-------XXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DMT--------------------------------------------------NALVGMS
PSSSLSALSSRA----------ASVSSLHERMLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 730)

TRVGREDGERRQDIVLSGHFIKEEHCIFRSDTRAGNEAVVTLEPCEGADTYVNGK
KVTEPSILRSXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----X----XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKEREKRPFPRTI---------------------------------------------
-VAIEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVGR---------------------------------------------------
------------------------------------------------------AF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQVTEIGPSA
DEVNNNTCAA-VTPEDLLLDSPE--------------------------KSIMDGPLESA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKDVLXXXXXXXX----XXXXX
XXXXXXXPATKLSTLTRPTAGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCLGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVQPSQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRSGLETLSPCSSEDSES
HSTSCVSSPLSD-GTSESRATTLDIPSERQKELAAKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLSAATLTPSSTCPSLVEGRYTAXXXXNPPPCSRPVSPELE
PVLE-GEQKKSPSPASGP-EAEKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPKTTGWAK
RFVVVRRPYAYMYNSDKDAVERFILNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI---------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERLLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGL

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 731)

TRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGTARQKARA--TLRRWGPSAPRAVGIREGRALARGARLGGEPGMGWHHGK
DGTWGKPGTALCKHPWLQRGRAERVIWXRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYFPEVNEE-EEEPEDEVPWTERECELALWAFRKWRWYQF-------TSLRDQLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVGSSVISGCSSYPLLNTCMSARMAALTPSPTSSSPDSDT--TEPAEEQSLGEEE
EE------------EEEEEEEEDLEDDVFLEHALCHG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPESLLLDSPE--------------------------KATLDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKPAQ--CPHKLSTLTRSCPGT-HCKYDLLVHFEICELEADGDYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTVSAYI--------EM-ENCAQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRS-
-----SESNRVTGVYDL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPAPETLSPASSEDSES
HSLSSASSPLSADGRAS----PPETPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLQDTSLSPLGVATLTPSSTCPSLVEGRYGAADLRSLQPNSRPASPEPE
NVPE-ADSKKIPSPARAT-ESDKEPQRPLVPDIQEVRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAK
RYVVVRRPYAYMYNNDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPHTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMT---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTTPE
DINYASQKQVYQDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKVSLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERMMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCIFRSDTRAGTEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1543)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQITDLGPTA
DEVNNNTCAV-TPE-DVLLDSPE--------------------------KNVMDGPLEAA
LEHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPTAGPCHCKYDLMVFFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCHGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIRPSQEDR-----------------AFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSVYV--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRSGQETLSPCSSEDSES
HSPSCVSSPDAPENRTS----P-ETPSERQKELAAKCLRLL-THTFNREYSHSHVCVSVS
-ESKLSEMSVTLMRDSSMTALGTTTLTPSSTCPSLVEGRYNTPVLRTPQLCSRPTSPEPE
PVLE-GEQKKSPSPTRGA-EEEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTNGWVK
RYVVVRRPYVYIYNSDKDSVERAILNL----SSAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSWL---QNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDCERRQDIVLSGHFIKEEHCVFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEE-------------EEEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VTPEGLLLDSPE--------------------------KTTLDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPASSEDSES
RSSSSASSPLSTEGRSS----PLEVPSERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLEAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LVPE-MDSKKLPSPVRVT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVER-FVLNL---ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGP----NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 724)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KIP

ENSGT00890000139327_0_Linker_8_9 (724, 1042)

IP----QGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRT-------------------------------------------I--
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDAT--EPAEEQSEE---
-------------EEEEEEEEEDLEDDVFPEHALCDG-RDPFYDRL--VGRLVRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2120)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLGRLQ----GEV------AAMGVLPSTGSWPGPFDRAL
LQDKTALPGVLPSIPSWRGPFSRASRRVRLLCQGSCPQGCLGKQCGQWKAVRPALTYVGW
GRP

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EEEEEEEEEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDRQFLDSDIPSVSLGNDTRTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EEEEEEEEEEEEDLEDDVFPEHTLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VTPEGLLDSPEK--------------------------TGALEGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPASSEDSES
RSSSGASSPLSAEGQPS----PLEVPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-IDSKKTPSPARAS-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTLPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGP----NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEGMATLPSPPAPTA--LG-
-HPVPASPALRNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDAT--EPAEEQSVGEEE
-----------EEEEEEEEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKPGRKVPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGP----NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 724)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KIP

ENSGT00890000139327_0_Linker_8_9 (724, 1042)

IP----QGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE----------EEEEEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLRLVR---SPIHACLPP
VPT---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2120)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLGRLQ----GEV------AAMGVLPSTGSWPGPFDRAL
LQDKTALPGVLPSIPSWRGPFSRASRRVRLLCQGSCPQGCLGKQCGQWKAVRPALTYVGW
GRP

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETSVTTEKV
SMASA-------------GGGRGVRLG----------QEGANINKSLTTLGKV---I---
-------SALAEM--------NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_5 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_5 (446, 477)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGL

ENSGT00890000139327_0_Linker_5_6 (477, 587)

GPGL
RMLPGPPGLCPP------------------------------------------LALGLA
PRAPCCPTFATAL---------LCVR----FCQEGPGLDPPLLCLA

PF16183 // ENSGT00890000139327_0_Domain_6 (587, 665)

LQETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_6_8 (665, 677)

ITRWGSPG---C

PF00498 // ENSGT00890000139327_0_Domain_8 (677, 737)

RDIVLSGHFIKEEHCVFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PSEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLVRAARRQA------
------------------PTWDPGGRGPCLLFSRLW--LQQ-------LPSSQHMH----
--ERA--------------------HGCSHPL---------------PHLLEPRL-----
--RRHRACRGAERGGGGGGGGGGGGPGGRRLSGARAVRRPGPVLRPA-------PPVQFS
RKVGEVEDSMLGRNQLFC------TGALLRAQFDRHQGVTP-------------------
----------------------------------GDLGSS-------LDPGQRQAEGLAS
------------------------------------------------------------
-------------------------------------------------LGREREAGPGD
GGGRVPRGEASAQWDS-----FCREA-P--GAR-QSRHAGPEGNTW---QGGG------A
HRCAHRELSS-SPPSALFQKRWREAPGPPPWEEEQTWRRPSRGQEGRAGAWAVKGPPSEA
LGTADP--------TLL-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_1 (62, 166)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRESKCIIQMS---GSTT---TILNPKQPKETPKSFSFDYSYWSHTTPA
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTHPAAEGSKYV---------SDFENNN-------GTSGAELSQRHDNLSTVTNAIAGIS
PSSSLSALSS-RA---------ASVASLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

TRVGREDAEKRQDIVLSGHFIKEEHCLFRSDTRTGGEVVVGLEPCEGADTYVNGK
KVTEPSVLRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVGS------NSSPLFNTCMSERMADLTPSPTFSNPDSDITE-------------
--------------------PADEQEDIFPECPLCDG-RDPFYDRSPLFSLVGSLSMPSL
HLTNLVVSVPALLPLVTHFVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPAVGMS-RSGTSQEELRIVE-GQGQISDLGPSA
DEVNNNTCAV-TPE-DLLLDSPE--------------------------KSTMDGPLEAA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPXVMPL
SKP---VPATKLSTMTRPSAGPCQCKYDLMVFFEICELEANGDYIPAVVDHRGGMPCHGT
FLL-HQGIQRRITVTLVHETGSLIRWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIHPSQDDR----------------RTFYQFETAWDSSMHNSLLLNRV-TPYREKIY
ITLSAYI--------EM-ENCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WLP----LILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGLESLSPCSSEDSES
RSTSCVSSPLSADGAPE----GRTP--------LPRAPHML-THTFNREYSHSHVCISAS
-ESKLSEMSVTLMRDPSMSALGVTTLTPSSTCPSLVEGRYNAVEVRALQVSSRLESPDLE
PVVE-GEQKK--SPARRP-EEEKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTNGWVK
RFVVVRRPYVYIYNSDKDSVERAILNL----SKAQVEYSEDQQAMLKQTPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSISFRIRSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

------------------------------------------------------------
---------------------------------IVNP

PF00225 // ENSGT00890000139327_0_Domain_0 (98, 442)

KQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTSNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNDE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLELMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE------------EEEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KTALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHHQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCRCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPEVLSPASSEDSES
HGSSSASSPISAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPPMSPLGPATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPAQAT-ETDKEPPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMR----------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------K

PF00225 // ENSGT00890000139327_0_Domain_3 (388, 442)

TDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_3_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGITRVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEGMATLPSPPAPTAL--GH
PV--PASPVLRNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE--------------------EEEEEEEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLRSS---SKPLPR----
-------SFHPLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SERDSHPGLGAGQAGLCLAAV-----LGPPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQA-
RNLFSRINEMTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKCNRGSVRGS
NSSPLSQGAQQGW---------TVSSGVHGGVRLHPGCRE--ATGLVEETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKDEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
REL-EKQGIDM---QEMEHRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELAMWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1543)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVAGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLLLDSPE--------------------------KAALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRRCPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRLC-PDKSSAH
ISFSGGV--------LM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLEATQRPGPEVLSPISSEDSES
HSSSCASSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADLRTPQPCSRPASPEPE
PVPE-ADSKKPPSPSPVS-EVDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMGKDSKCIIQMT---GNTT---TIINPKQPKETPKSFSFDYSYWSHTTPD
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGRQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DMT--------------------------------------------------NALVGMS
PSSSLSALSSRA----------ASVTSLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCLFRSDTKGGSE-VVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEE-EEPEDEVQWTEREFELALWGFRKWKWYQF-------TSLRDQLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1088)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV

ENSGT00890000139327_0_Linker_9_12 (1088, 1543)

GR---------------------------------------------------
------------------------------------------------------AF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQITDIGPSA
DEVNNNTCAA-TPEDL--LDSSE--------------------------KSAVDGPLETA
LEHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSAMTRPSVGPCQCKYDLMVFFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCHGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPEGDESLIDPNILSLNIL
SSGYICPSQDDRQFLDSDMPSISLGNDTRTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGLDSLSSSSSDDSDS
RSTSCVSSPISADGTPEGRNLPLDMPNERQKELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLMRDPSMPALGGSTLTPSSTCPSLVEGRYTATDARPLQLSSRVESPESE
HAIE-GEQKKTPTCG---PEDEKEIQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SRKGYLHFLEPHTNGWVK
RYVVVRRPYVYIYNSDKDSVERAVLNL----SSAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQACNDKDMHDWLYAFNPLLAGSI----RSKLSRRRTAQTRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRESKCIIQMS---GSTT---XXXXPKQPKETPKSFSLDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DMT--------------------------------------------------NALVGMS
PSSSLSALSSRA----------ASVSSLHERLLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKXXXXXXXXXXXXXXXXXXXX
XXXXX

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

XXVGR-EAERRQDIVLSGHFIKKEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMG
SRYCPEANEEE-EEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVGR---------------------------------------------------
------------------------------------------------------AF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKLQSESCPVKGLT-RSGASQEEMRIVE-GQGQGVDAGPSA
DEVNNNTCSA-VPPEGLPLGSPE--------------------------KAALDGPLDAA
LDCLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIRSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPPRRHSPRLMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCTGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVXXXXXXXXXXXXXXXXXX------
-----------XXXXXXXXXXXXXXXXXXTFYQFEAAWDSSMHNSLLLNRV-TPHREKIY
VTLSAYI--------EM-ESCTQPAVITKDFCMVFCSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADAGSPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX--XX-XXXXXX-XXXXXXXXXXXX-XX-----XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCLRLL-THTFNREYVHSHVCTSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRIPQPSSRPASPEPE
PTPE-AESKKTPSPAQGA-EADKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILQQANSDKDMHDWLYAFNHLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DIKYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SVALVHE-------------ASCPLCT----------QEGANINKSLTTLGKV---I---
-------SALAEMVSQL---WNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DMT--------------------------------------------------NTLVGMS
PSSSLSALSS-RA---------ASVSSLHERMLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMG
SRCFSEANEE-DEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKERETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQATS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGAEAGPSA
DEVNNNTCSA-VPPEGLLLDSPE--------------------------KAALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLARPCPGPCHCKYDVLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDRVSFG-NDT--------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVRLRSSG---------------ADCGPQGARXXXX
XXXSGPASPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADLRTPQPCSRPASPEPE
PVPE-ADSKKLPSPARAV-EADKEPPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYCDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNNNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
ETNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDTRAGSEAVVTLEPCEGADTYVNGK
KVMEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEELEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSAVEDCENVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAVSGCSSYPLLNTCMSERMAALTPSPTSSSPDSDSEATEPAEEQSVGEEE
EEEE------EE---EEEEEEEDLEDDVFLERALCDG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNSCSA-VPPDGLLLDSPE--------------------------KA--------T
LDHLHLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYLHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCMQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPASSEDSES
RSSSGASSPLSAEGRPS----PLEAPSERQRELTVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGSPDVRTPQPCSRPSSPEPE
LVPE-THSKKPPSPVQAA-ESEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EE-----EEEEEDLEDDVFPEHTLCDG-QDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLMDSPEK--------------------------A-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDEALIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYSATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPVRAT-ETEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DVKYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGHLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DSEC----LCPPVLG----RTARHVSDLENNN--RNRGGVELSPAPDNLSTVTNALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

TRVGREDAERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLHELEDHPQREARVG--GRGRVCTRVDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVGS------NSYPLLNTCMSERMAALTPSPTFSSPDSDATEPA--EEQSVGEE-
-----------E-------EEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQATS-----------ADEEAPDY
GSGVRQSGTGSPSTTSI-L--FQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSAAAPPEGLLLDSPE--------------------------KAALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKTQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLARPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSDYIHPAQDDRSLL-----------PSRTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFHSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEAPSPASSEDSGS
HGSSSPSSPLSAEGRPS----PPEAPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRTPQPCSQPASPEPE
PVPE-ADSKKLPSPARAA-EADKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAK
RFVVVRRPYAYLYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 373)

RVRPFNSREMSRDSKCIIQMS---GSTTSEYRPAR--QPP--------AASSPPRPQPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTSNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGPARLL---------------------QPDLPEGLSG--------
------PHLPLSPPYADRAKQIRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1594)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDAT--EPAEEQSVGEE-
------------EEEEEEEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KTALDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
FLL-HQVRVSSL----------CDPWP----VA

PF12473 // ENSGT00890000139327_0_Domain_12 (1594, 1719)

FSAGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETAQRPVPELLSPASSEDSES
HGSSSASSPLSAEGRPS----PLEAPNERQRELAVKVGLAGGQHRRARQPSLVHAC--PT
SHLQLSEMSVTLLRDPPMSPLGPATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPAQAT-ETDKEPPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDAVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMR----------------
------------------------------------------------------------
---

------------------------------------------------------------
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-------MSVTLLRDPSMSPLGATTLTPSSTCPSLIEGRYGAADLRTPQPCSRPASPEPE
PLPE-VDAKKPPSPARAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTIRYGRRAAQGRAAVAQGLSAPQR---PEQ-----
VAEAEGLD----------------------------------------------------
---

MSSLGRRLNSDPGSSPCTDLPFALWMECRFPEPLLFPSQDGLCSPRQERGAMAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TILNPKQPKETPKSFSFDYSYWSHTTPA
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTHPAA-----------------------------------------GGSKLTNAIAGIS
PSSSLSALSSRAASVGGGGGGGGGVASLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAEKRQDIVLSGHFIKEEHCLFRSDTKSGGEVIVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1088)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV

ENSGT00890000139327_0_Linker_9_12 (1088, 1543)

GR---------------------------------------------------
------------------------------------------------------AF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGMAKISFDDQHFEKFQSESCPAVGMS-RSGTSQEELRIVE-GQGQVSDVGPSA
DEVNNNTCAV-TPE-DLLLDSPE--------------------------KPASDGPLEVA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPTAGPCQCKYDLMVFFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCHGT
FLL-HQGIQRRISVTLVHETGSLIRWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIHPSQDDRQFL--------DSDMPRTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
ITLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGMETLSPCSSEDSES
RSTSCISSPLSADGAPEGRTSPPETPSERQKELAVKCLRLL-THTFNREYSHSHVCISAS
-ESKLSEMSVTLMRDPSMPALGVTTLTPSSTCPSLVEGCYNAMEVRPPQVSSRAESPDLE
TVVE-GELKK--SPARRP-EEEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTNGWVK
RFVVVRRPYVYIYNSDKDAVERAILNL----SKAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------MSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADLRTPQPCSRPASPEPE
PGPE-ADARKLPSPARAP-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2116)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFLLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWL-AFNPLLARPR----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TILNPKQPKETPKSFNFDYSYWSHTTPA
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLL-PKNKGNLRVREHPLMGPYVEDL
SL-AVTSY-DIQDLMTLNKPGDTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DMAPGSDGLSICAAS----DVSDFENNN-------DAGGAELSQRHDNLSTVTNAIAGIS
PSSSLSALSSRA----------ASVASLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAEKRQDIVLSGHFIKEEHCLFRSDTKTGGEVIVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEE-EEEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKLRSICVTYTRKLQQKGFPSIHTGSID------CYIYAPDV-----
-------RSLFPISLDLS--------------GQNPSPKP----------------NQ--
-----L-KTKKAKFLFFLFEQL----------------VLTCLLSCCTN-----------
-------LSSDISGCNSSPLFNTCMSERMADLTPSPTFSNPDSDITEPA--DEQHQG---
-------------QEEEEEEEEDLEEDIFPECPLCDG-RDPFYDRFPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVK-FLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEK--SESCPAVGMS-RSGTSQEELRIVE-GQGQVSDVGPSA
DEVNNNTCAV-TPEDL--LDSPE--------------------------KPAPDGPLEVA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSAGPCQCKYDLMVFFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCHGT
FLL-HQGIQRRISVTLVHETGSLIHWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIHPSQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
ITLSAYI--------EA-RTFLGPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGMETLSPCSSEDSES
RSTSCISSPLSADGAPESRTSPPETPSERQKELAVKCLRLL-THTFNREYSHSHGCVAGR
GMA----QVMPLLGDPSMPALGVTTLTPSSTCPSLVEGCYNAMEVRPPQVSSRAESPDLE
PVVE-GEQKK--SPARRP-EEEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTNGWVK
RFVVVRRPYVYIYNSDKDAVERAILNL----SKAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSI----RSKLSRR----------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EE-----EEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLHLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPIPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHECLLFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQRQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1543)

GRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQATS-----------ADEEAPDY
GSGVRQSGTARISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VSPEGLLLDSPE--------------------------KAPLDGPLDAT
LDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLARPCPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSDYIHPAQDDRQFLDSDMP--------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTVSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEAPSPASSEDSGS
HGSSSPSSPLSAEGRPS----PVEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRTPQPCSRPASPDAE
PVPE-ADSKKLPSPARAT-EAEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYLYNSDKDSVERFVL-NL---STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

------------------------------------------------------------
---------------------------------

PF00225 // ENSGT00890000139327_0_Domain_0 (94, 433)

IVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGRQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRLKXXXXXXXXXXXXXX-------------------
-------XXXXXXXXXXXXXXNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXX
XXXXXX-----------------------------------------XXX---XXXXXXX
XXX-XXXXXX-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGITRVGREDGERRQDIVLSGHIKEXX-XXXXXXXXXXXXXV

PF00498 // ENSGT00890000139327_0_Domain_8 (705, 737)

VTLEPCDGADTYVNGK
KVTEPSILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PSEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRKEREEA--TYLLEQQRLDYESKLEALKKQMD
SRYYPEVNEEE-EEPEDEVQWTERECELATWASRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSIIEDCDNVVTGGDPFYDR
FPWFRLVGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------
--------------------X---------------X-----------XXXXXXXX---X
XXXXXXXXXX-----XXXXXXX------------------X-----------XXXXXXXX
XXXXXXXXXXXXXXXX-----XXXXXXXXXXXX-XXXX---XXXXXX--XXXXX-----X
XXXXXXXXXX-XXX-XXXXXXXX--------------------------X--------XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFIHRHDEAFSTEPMKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLXXXXXXXXXXXXXXXXX
X----XXXXXXXXXXXXXXXXXXXCKYDLLEYFQF-ELEANGDYIPAVVDHRGGVPCMGT
FLLHQXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX------X--XXX----------
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYIEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
-----XXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXXXXXXXXXXXXX----XXXXXXX-----XXXXXXXX-XXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX--XXX
XXXX-XXXXXXXXXXXXX-XXX----XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMV----------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDMRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVTSGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE--------------EEEEDLEDDVFLERALCDG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGTDTGPSA
DEVNNNTCSA-VSPDGLLLDSPD--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFVEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFFQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHMADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPVSSEDSES
RSSSGASSPLSADGHPS----PLEAPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDMRTPQPCSRPSSPEPE
LLPE-ADPKKLPSPVPAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TILNPKQPKETPKSFSFDYSYWSHTTPA
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTHPAA-----------------------------------------GGSKLTNAIAGIS
PSSSLSALSSRA----------ASVASLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAEKRQDIVLSGHFIKEEHCLFRSDTRTGGEVIVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSDISGCNSSPLFNTCMSERMADLTPSPTFSNPDSDITEPA--DEQHEG---
-------------QEEEEEEAEDLEEDIFPECPLCDG-RDPFYDRSPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPAVGMS-RSGTSQEELRIVE-GQGQISDLGPSA
DEVNNNTCAV-TPE-DLLLDSPE--------------------------KSTMDGPLEAA
LDHLKLGSIFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSAGPCQCKYDLMVFFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCHGT
FLL-HQGIQRRITVTLVHETGSLIRWK--EVRELVVGRIRNTPEADESLIDPNILSLNIL
SSGYIHPSQDD-----------------RTFYQFETAWDSSMHNSLLLNRV-TPYREKIY
ITLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCRVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRLGLESLSPCSSEDSES
RSTSCVSSPLSADGAPEGRTSPPETPSERQKELAVKCLRLL-THTFNREYSHSHVCISAS
-ESKLSEMSVTLMRDPSMSALGVTTLTPSSTCPSLVEGRYNTMEVRTPQVSSRVESPDLE
PVVE-GEQKKSPA--RRP-EDEKEPQRQLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTNGWVK
RFVVVRRPYVYIYNSDKDSVERAILNL----SKAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGSI----RSKLSRRRTAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGLQTSGNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
D--------------------------------------------------MTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKVR--------TT
WTREAQRSE----GAEALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VTPEGL-LDSPE--------------------------KTALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDRVSFGN-DT--------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRG-
-----GRGGG---CFKE--GT-HQRDRGGPPLPTLGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSLASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-IDSKKTPSPARAT-EVDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EEEE--EEEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-TDSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREIGKDSKCIIQMS---GNTT---TIVNPKQPKETPKSFSFDYSYWSHTSEE
DSQYAGQRQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPTQQGIIPQLC
EDLFSRISDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYQDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDADAQTTTEKV
TYSDIWGL--INPEVPHSFTHSLC-YI----------LLGDNMAVASVGLFHI---L---
-------LSISLQDSG--TNKNKKKKKNDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLIRELKDEVARLRDLLGAQGLSDII
DSEDDFLDISVGSFVIREKRLRGCQHSRAQFCL-----LNETNLPRGFLTQSVNALTGMS
PSSSMSGLSSRA----------ASVTSLHERLAFTPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMDREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

TRVGREDATMRQDIVLSGHFIRDEHCIFRSDVLACGSVVVTLEPCDGADTYVNGK
KLTDPCILRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PSEPVDWAFAQ
RELLEKQGIDMK--QEMDQRLQELEDQYRKEREEA--NYLLEQQRLDYESRLEALQRQMD
SRYFTEVNEEE-EEPEDEVQWTEQEYDLALWAFRKWKWYQF-------TSLRDQLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--HTEREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDMMREMYDRAAELPSGLTEDCDNVVTGGDPFYDR
FPWFRLVGS--------SPLFTTCMSESMAEITPSPTLSSPGSEGPEPASQL--------
-------------EEEDIFQDDEEEDDGPQEHPCCAVRSDPFHDRSPLFSVVGRAF---V
YLSNLLYSVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFQK--AETCP--GMT-RSGTSQEELRIVEGGQGQNPDSCPSA
DEVNNNTCAASLQS--SLLDSPT----KPPFDLSD-----------------------TM
GHPLKLGSIFTFRVTVLQASSIPPEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTQSFVEYVKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRSSRRLLPRVMPL
SKP---VPATKLSRQRVPSVGPCHCKYDLMAYFQICELEANGDYIPVSVDHGVGLPCHGT
FLL-HQGIQRRISVTLVHEAGAELKWLEVRELVVDLGRIRNTPEADESLIDPNILSLNIL
SAGYRPPEGGDR-----------------TFYHFEVAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYV--------EM-ENCTQPAVITKDFCMVFYSRDAKLPACRSIRNLFGTGSLRA-
-----SESNRVTGVYEM--SLCRVAET-----SSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLEATLRGATESLTPSPIEEMLP
LSPTCQPLQLTEVGSPRAEENPLETASERQKELAAKCLRLL-THTFNREYSYSHVCVSAS
-ESKLSEMSVTLLRDPSLSGLGVNSLTPSSTCPSLVEGRYCSPEARSPQPISRVFSPERE
LLSPAGDLLKSPSG-----ELKTPTLNLFVPEIQEVRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTGGWVK
RYVVVRRPYVYIYNSDRDPVERAILNL----SQAHVEYSEDQQAMLK-TPNTFAVCTQHR
GILLQASNDKDMHDWLYAFNPLLAGSIR---RSKLSRRRSAQMRI---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DFNYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
GGSAGRPT--C------KTLASGFR-P----------PEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLIRELKDEVTRLRDLLYAQGLGDIA
DMT--------------------------------------------------NALVGIS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGITRVGREDGERRQDIVLSGHFIKEEHCIFRSDSRGGTEGIPALP-CSRSELGGHGG
RWTGPYLCEEG-APDMGRE--AIFNSHFR-------VDISPCFLIMPLAKTLREPWAKGR
HAPVPPHPQCLL--TPGPRRLQELEDQYRKEREEA--TYLLEQQRLDYESKLEALKKQMD
SKYYPEVNEEEEELEDEAPDAS-----MVERHFKCFPWRKGQVKARGPTGSSQCCWGMRA
GLRAAAGLAGTS-----------------------------RELLPGPEVLLS-HCLL--
----------------------------------HSIPLPPPLLNLRDGVSPKVLPALTT
LIHMHIAFLYNSYSHIWFL--FWQRLDLMREMYDRAAEVPSSIIEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLDS-PE--------------------------KSMLDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-SGALPTNHPSSQA---WGAHTGDMRVLVSLGRSLGCAVVKL-
---------RTHQLFRWRKDLASSLP-----KGAL----V--------VQ------RLHG
AAPRD-GAGEEPRWRQGWLHPGSRQVEKTRHYLLLREKLETHQRPGPEVLSPIYSEDSES
R-SSGASSPLSAEGRPS----PLEVPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYN-TDLRTPQPCSRPASPEPE
PVPD-VDTK-KPSPTLTT-ETDKEPQRLLVPDIQEIRVSPI

PF00169 // ENSGT00890000139327_0_Domain_14 (2022, 2124)

VSKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXTVATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMVP-----ENKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DMT--------------------------------------------------NALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX--XX--X---XXXXXXXXXXXXXXXXXXXX----XXXXXXXXX-X-XXXXXXXXX
XXXXX----XXXXXXXXXX--XXXXXXXXXXX-XXX---XXXXXX----XXXXXXXXXXX
XXXXXXXXXXXX--XXXXXXXXXXXXXXX--XXXX--XXXXXXXXXXXXXXXXXXXXX--
------------XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX
XXXXXXXXXXXXXX-X-XXXXX-XXXXXXXXXXXXXXX---------XXXXXXXXXXX--
--XXXXXXXXXXXXXXXXX-----------X----X----XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXQRLDLMREMYDRAAEVPSSAIEDCDNAVTGGDPFYDR
FPWFRLVGRAF-------------------------------------------------
-----------------------------------------------------------V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKXXXXXXXX-XXXXRSGTSQEE-RRVE-GQGQGADAVPSA
DEVNNNTCSAVLPEG-L-LDSPE--------------------------KAVLDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXGVLSPLRPSRRHFPRVMPL
SKP---VLATKLSTMTRPSSGLCHCKYDLLVYFEICELEANGDYIPAMVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYMHPAQDD-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRESKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTSTVP-----------------------------------------GGPRLTNALVGMS
PSSSL------RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAEKRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--LEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEEEE-PEDE---GEGSCPAQGRAGPAWGWGGV--------SLRRGAWGHSL
RVGWSTSLSGGPRSAGRICWLAPCADVAWTPLSGLVCLGGGRGTRPQPVLLPTPHCCPQS
LLSSGLTLRPSRSRRGRGGPSGAQGP------LPESVSLPGPFPN---------------
----------------------------------------------------------AP
DSWFDPGGPKTPAPHRRGPPLRTXEERRQAPFRPSPSRC-PSPASCPTDPSEERGVGRGT
AE----------RGGAKGSKERGSHQAAVPSGSPCPG-LHLMRAALTAASPLPRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQPQAAFQAESCPGVGMS-RSGTSQEELRIVE-GQGQAADSGPSA
DEVNNNTCSA-AVTPESLLDSPE--------------------------KATLDGPLDAA
LDHLGLGSTFTFRVTVLQASSISAEYADIFCQFK-------AFSTEPLKNTGRGPPLGFY
HVQNIAVEVTRSFIEYIKSQPLVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPPHRQGAQVVIPDFCLITAGGGVIKLTVAIRSGKRRRQV
GVL-TPGSSRVT-------PCPHHNWGGEILQELFMGRIRNTPETDESLIDPNILSLSIL
SSGYICPAQDDRLSKHWQGITEAGP-----------------HDASAVSVVTLELQENRT
CLRQQLA--------PM-ESCAQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADAG-----SPGRCL-----------------PLAL
W----------------------------------------------PGLGPGLSEDSEA
PVSSSTSSPLTAEARPA----SLEAPSERQRELAFKCLRLL-THSFNREYTHSPVCKRQR
EQVELSEMSVTLLRDPSMSPLGATTLTPSSTCPSLIEGRYGAADLR--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EE------EEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLHLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPIPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDMRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQME
SRYYPEVAEEEEEELEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EE-----------EEEEEEEEEDLEDDVFPERALCNG-RDPFYDRSPLFSVVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VSPDGLLLDSPE--------------------------KAVLDGPLDAT
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLVHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----AEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPVSSEDSES
RSSSGASSPLSAEGRPS----PLDVPSERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAADARTPQPCSRPSSPEPE
LMPE-ADSKKLPSPVRVA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYSSDKDPVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQASSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EEE---EEEEEEDLEDDVFPEHELCDG-QDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPIPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
D--------------------------------------------------MTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_10 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_10 (1042, 1193)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLV-----------------------------------------------------
----------------------------------------------------

ENSGT00890000139327_0_Linker_10_12 (1193, 1544)

GRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGLMDSPE---------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDEALIDPNILSLNIL
SSGYVHPAQDDRQFLDSDIP--------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPVRAT-ETEKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 443)

RVRPFNSREMSRESKCIIQMS---GSTTNG------TAPKITPSSLRHRQSRRCRCQPP
PWHAATSKGRCSLTSEKK-FFLISNQKNCLTS-EQD---------AQGRSQREGQVGELC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLMGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVARLRDLLYAQGLGDII
DTHPAAGGSKYV---------SDFENN-------NGTIGTELSQRHDNLSTVTNAIAGIS
PSSSLSALSSRA----------ASVASLHERIMFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGI

PF00498 // ENSGT00890000139327_0_Domain_8 (666, 737)

TRVGREDAEKRQDIVLSGHFIKEEHCLFRSDTRTSGEVIVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIMGKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--NYLLEQQRLDYESKLEALQKQMD
SRYYPEANEEE-EEPEDEVQWTEREFELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPDA-----
--AKDREKRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSMG---
-EEE------EEE----EEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSASSPLSTEGRPS----PLEAPSERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-TDSKKLPSPARAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNLSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMN--------KKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSVLRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDATE--PAEEQSVG---
-EEE------EE-----EEEEEDLEDDVFPEHELCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLHLDSSE--------------------------KAALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDD-----------------RTFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEAPSPAFSEDSEP
HGSSSASSPLSTEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
LLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDAVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMVSGPN--K--KKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

IT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSAISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDA--TEPAEEQSVGEEE
EEEE------EEEEEDEDEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADVGPSA
DEVNNNTCSA-VPPEGLLLDSSE--------------------------KAALDGPLDAA
LDHLRLGNTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLRSPIH------ACLRP
VPT---VPATKLSTLTRPCPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPAFSEDSES
HGSSSSSSPLSAEGRPS----PLEAPNERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPE
PLPE-ADSKKLPSPARAT-ETDKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2120)

SKKGYLHFLEPHTSGWAR
RFVVVRRPYAYMYNSDKDTVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQAASDKDMHDWLYAFNPLLGRLQ----GEV------AAMGVLPSTGSWPGPFGRAL
LQDKTALPGVLPSIPSWRGPFSRASRRVQLLCQGSCLQGCLGKQCGQWKAVRPALTYVGW
GRP

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTR-L----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGPN--KNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPR-------------------------------------------TIV-
--AVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSNPDSDT--TEPAEEQSVGEEE
KEEE------EE---EEEEEEEDLEDDVFPEHTLCDS-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGL-LDSPE--------------------------KGTLDGPLDTT
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADAG-----SPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPVSSEDSES
RSSSGASSPLSAEGQPS----PLETPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGTATLTPSSTCPSLIEGRYGASDVRTPQPCSRPASPEPE
LLPE-ADSKKTPSPARAT-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRKSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DSEC----LCPPVPG----PGQADVSDLENNN--RNRGGAELSPAPDNLSTVTNALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDGIT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEEE-EEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRT----------------------------------------------
IVAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1543)

S------NSYPLLNTCMSERMAALTPSPTFSSPDSDATEPA--EEQSVGEE-
-----------EEEEEEEEEEEDLEDDVFPEHALCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAVVSEKGEVKGFLRVAVQATS-----------ADEEAPDY
GSGVRQSGTARISFDDQHF--EKSESCPVVGMS-RSGTSQEELRIVE-GQGQGADTGPSA
DEVNNNTCSA-VPPEGLLLDSPE--------------------------KAATDGPLDAA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTLARPCPGPCHCKYDLLVYFEICELEANG

PF12473 // ENSGT00890000139327_0_Domain_12 (1543, 1720)

DYIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSDYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSRD

ENSGT00890000139327_0_Linker_12_14 (1720, 2023)

AKLPASRSIRNLFGSGSLRA-
-----SESNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEAPSPASSEDLGS
HGSSSPSSPLSAEGRPS----PLETPNERQRELAVKCLRLL-THTFNREYTHSHVCISAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAAELRTPQPCSRPASPEPE
PVPE-ADSKKLPSPARAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYLYNSDKDSVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQILQRAGVTLTTASIINPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETDITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEM--------NKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AVINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DSECP------------------------------------------HARPLTNALVGMS
PSSSLSALSSRA----------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 732)

RVGREDGERRQDIVLSGHFIKEEHCVFRSDSRGGSEAVVTLEPCEGADTYVNGK
KVTEPSILRSG

ENSGT00890000139327_0_Linker_8_9 (732, 1042)

TAAARGGGRPGVRPVPHRAPGQPQDRTRKTCAQTTQCH---KAKHAQAQ
TRTHTKQGIDMK--QEMEQRLQELEDQYRREREDGPTQSLLEQQRLDYESKLEALQKQMD
SRYYSEVNEEE-EEPEDEVPWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1562)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSEAT--EPAEEQSVG---
-------------EEEEEEEEEDLEDDVFPEHVLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVGGMS-RSGTSQEELRIVE-GQGQGADAGPSA
DEVNNNTCSA-VPPEGI-LDSPE--------------------------KAALDGPPDAG
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNT-QKVTKSFVEYIKSQPS----WGHDTPSPVPPRAGQ-VAQPLPPARGPLPSVPAP
SVP--AVPATKLSTLTRPSPGPCHCKYDLLVYFEICELEANGDYIAGVVT-TGGMPAMGL
L

PF12473 // ENSGT00890000139327_0_Domain_12 (1562, 1719)

LHQGKGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYIHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVVTKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSPK-LFDSASSRAS
HSCSEVHHNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPVPEALSPASSEDSES
HSSSSASSPLSAEARPA----PLEVPSERQRELAVKCLRLL-THTFNREYTHSHVCVSAS
-ESKLSEMSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGATDLRTPQPCSRPPSPEPE
LLPE-SDSKKTPSPVRST-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTSGWAR
RYVVVRRPYAYMYNSDKDSVERFVLNL----ATAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQATSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
------------------------------------------------------------
---

---------------------------------------------------MAGASVKVA
V

PF00225 // ENSGT00890000139327_0_Domain_0 (62, 442)

RVRPFNSREMSRDSKCIIQMS---GSTT---TIVNPKQPKETPKSFSFDYSYWSHTSPE
DINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLC
EDLFSRINDTTNDNMSYSVEVSYMEIYCERV--RDLLNPKNKGNLRVREHPLLGPYVEDL
SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKV
SKISLVDL--AGSERADSTGAKGTRL-----------KEGANINKSLTTLGKV---I---
-------SALAEMDSGP--NKNKKKKKTDFIPYRDSVLTWLLRENL-GGNSRTAMVAALS
PADINYDETLSTLRYADRAKQ

ENSGT00890000139327_0_Linker_0_4 (442, 446)

IRCN

PF16183 // ENSGT00890000139327_0_Domain_4 (446, 665)

AIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDIT
DTNTVP-----------------------------------------GGPKLTNALVGMS
PSSSLSALSS-RA---------ASVSSLHERILFAPGSEE--AIERLKETEKIIAELNET
WEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYY
IKDG

ENSGT00890000139327_0_Linker_4_8 (665, 667)

VT

PF00498 // ENSGT00890000139327_0_Domain_8 (667, 737)

RVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGK
KVTEPSILRSGNRIIM

ENSGT00890000139327_0_Linker_8_9 (737, 1042)

GKS--HVFRFNHPEQA-RQERERTPCAET----PAEPVDWAFAQ
RELLEKQGIDMK--QEMEQRLQELEDQYRREREEA--TYLLEQQRLDYESKLEALQKQMD
SRYYPEVNEE-EEEPEDEVQWTERECELALWAFRKWKWYQF-------TSLRDLLWGNAI
FLKEANAISVELKKKVQFQFVL-LTDTLYSPLP--------------PDLLPPEA-----
--AKDRETRPFPRTI---------------------------------------------
-VAVEVQDQKNGATHYWTLEK

PF12423 // ENSGT00890000139327_0_Domain_9 (1042, 1089)

LRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDR
FPWFRLVG

ENSGT00890000139327_0_Linker_9_12 (1089, 1544)

SSVISGCNSYPLLNTCMSERMAALTPSPTFSSPDSDTTE--PAEEQSVGE--
-EEE------EEE---EEEEEEDLEDDVFPEHTLCDG-RDPFYDRPPLFSLVGRAF---V
YLSNLLYPVP-----LVHRVAIVSEKGEVKGFLRVAVQAIS-----------ADEEAPDY
GSGVRQSGTAKISFDDQHFEKFQSESCPVVGMS-RSGTSQEELRIVE-GQGQGADSGPSA
DEVNNNTCSA-VPPEGLLDSPEK--------------------------S-ALDGPLDTA
LDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFY
HVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD-VLSPLRPSRRHFPRVMPL
SKP---VPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGD

PF12473 // ENSGT00890000139327_0_Domain_12 (1544, 1719)

YIPAVVDHRGGMPCMGT
FLL-HQGIQRRITVTLLHETGSHIRWK--EVRELVVGRIRNTPETDESLIDPNILSLNIL
SSGYVHPAQDDR-----------------TFYQFEAAWDSSMHNSLLLNRV-TPYREKIY
MTLSAYI--------EM-ENCTQPAVITKDFCMVFYSR

ENSGT00890000139327_0_Linker_12_14 (1719, 2023)

DAKLPASRSIRNLFGSGSLRA-
-----TEGNRVTGVYEL--SLCHVADA-----GSPGMQRRRRRVLDTSVAYVRGEENLAG
WRPRSDSLILDHQWELEKL-SLLQEVEKTRHYLLLREKLETTQRPGPEALSPASSEDSES
RSSSGASSPLSAEGQPS----PLEAPNERQRELAVKCLRLL-MHTFNREYTHSHVCISAS
-ESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPE
LLPE-LDSKKTPSPTGAA-EADKEPQRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDTVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
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-------MSVTLLRDPSMSPLGAATLTPSSTCPSLVEGRYGAPDLRTPQPCSRPASPEPE
PLPE-ADSKKLPSPARGASEADKETPRLLVPDIQEIRVSPIV

PF00169 // ENSGT00890000139327_0_Domain_14 (2023, 2121)

SKKGYLHFLEPHTAGWAK
RFVVVRRPYAYMYNSDKDAVERFVLNL----STAQVEYSEDQQAMLK-TPNTFAVCTEHR
GILLQANSDKDMHDWLYAFNPLLAGTI----RSKLSRRRSAQMRV---------------
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