Query Results 

----------------------MDPDSLHL-GNKNLCGWLVRLLSTKQEWLRAKMKFFLP
DVDLASSDEVPDL---EQRVILRLRELQAQGPTIWQSFIHCVCMELEVPLDVEVPLLSTW
GQD-DEF-A-------------------------R-LLETGDESQSGSQLHHGLKRP---
CQSCESSPRQK-HCRKHRL----ELAQNYLKLLRTSALTHYGDGLS------GPGK----
---IYVPPILQWSRATVSLDTQGGAI---T-GDPKIEDG--SDVSIQDLFNF-KTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARWLSHKWADGHLDNFQALFLFEFRQLNLITHFLTLPQLLFDLYL
RPESG-PDVVFQYLEENANQVLLIFDGLDEALYPCSSM-------ETVGPNDTGLALTLF
SSLCRGTLLPGCWVMATSRPGKLPACLPTEA-AMVHMWGFDQLRVEEYVNHYFSDQP-SQ
EVALTELLANRHLRSMCVVPALCHLACLCLHH-LLPASLPDQSVASLLPTMTQLYMQMLL
TCSP---------------LPAKLLVGLGEVALSGLETGKVIFYDS-DIPQPVMAFGATH
HLLTSFCVCTGPGHQETGYAFVHFSLQEFFAAIYLMTSPIVDKDILARHVILNSPWVLRT
--KARLGL-TDHLPTFLAGLASYTCRPFLSQVAQQDETWVGTRQAAVVQLLRKLATRKLK
GPKVVQLCHCVAETQEPELAGLTAQSLPYQLPFHNFPLTYADLAALTSVLEHRATPIQLE
FEGCPLEPHCPEALVGCTQVETLS-FKSRKCGDTFAEVLSRSLPTMGSLKKLGLAGSKIT
ARGISHLVQALSLCPQLEELSLQDNQLKDQEVLSVVEIMPSLPRLQKLDLSHSSFSISSL
FYLVKVAVTCPTVQTLQVREADLVFLLSPSTETAEDLQRAPDLPEKDS-QRKESQSRTLV
LR----LQKCQLRVHHAEVLVELLREVP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1008)

RLEEVDLSGNQLEDEGCRVLVEAASHLHITGK
LDLSDNHLSVDGVSCVLRAVNSCESLAE-LHISLLQKTVVLMFAQEAD---ERQGTQERA
AFLDDLTS--STDSEPP---RGIRLTHCGFLA-KHLEELCKALEGSHHLARHGHL--DFS
GNALRDEGTALLAQLLPGLGPLQSLNLSENDLSLDAVFHLAQCLSTLQWVCHLEVSFESQ
HIL---LRGDKR-GRDKLTG------GCLPEFPAGAQLSR--FHQHCIPRSFCLKE--CQ
LQPPSLIRLCTALEKCPGPLEVQLSCKALSDR----SLETLLHCLPQLPQLSLLQLNQTG
LS---PKSPLLLADIV----NQ-C--PRVQKVDLRSLHNVTLCFGPRKKQDVVCCG-FTG
CSLRQEHVEPLCRALS-KC-DN------LYQLDLTANL----LGDDGLRCLLE---HLSQ
MPISGLLDLSHNSISQEGVLHLLGTLPSCPRVRE-ASVNLGSTQNFWVHFSKQDEP-RMA
L--RLNEC-SFGQEHMPRLASSISQALQ--LTELTLTQCGMDPKQLAILLRLVRRPSGLL
GLRVEEPWVGRAGVPALLEV-----CAKVSGN-VTVISISKTQ----------QQLYVQL
EFPRQEENPEASAL---------------RLAHCDLGTHHNLLVRQLMETCTRLQQLSLS
QVNLCDASD----A-SLLLQSLLLSLCQLKTFRLTSSCVSNQGLTHLAAGLGHFYHLEEL
DFSNNQVDE--QGTEALIGILEGKCRLTRLHLSDLLLGSSTLATLTQKLSHMN

PF13516 // ENSGT00860000133673_1_Domain_13 (1794, 1892)

LLQ----
------------------------------------------------------------
-HLC-------------LSRNQIGDTGAQHL

ENSGT00860000133673_1_Linker_13_15 (1892, 1899)

AATLPGL

PF13516 // ENSGT00860000133673_1_Domain_15 (1899, 2013)

PRLRTID---------------
------------------------------------------------------------
------------------LSVNGISLAGGLQLAESLTLCRHLEEVRIGHNALEDPTALTL
AQRLPQ-

PF13516 // ENSGT00860000133673_1_Domain_20 (2048, 2079)

-HLRVLH---------LQSS--HLGPEGALSLGQALDGCPHVEDISLAENRLA
RGVPHFC----KGLPLLKR------MDLSACEIDNQTAKGLVASFALCPALEEILLSWNL
LGDEAAAELAQILPRMSRLKRVDLETNRITAAGAWLLAEGLSQGSGVHVIRLWNNLVPPA
VAQRLQSQEPRLDFAFFDSRQTPQ----

----------------------MEGAEFHD-VIANFLPRLEDYFCSDLAYFLQKIDVFLP
NVDFSHIIQLPDI---KMKVSSLLRELLVRHTESLKNIIQSVCMDGVLPMDLEVELISMI
GEGMFCISI---------------------L----QRGEEETTDCWLSSEIAGIKRQKFK
VFHSKTPKFKL-WCKKYKK----DLIGRFKEKITNSLLQKYHFKSKEES-------SQ-D
VRQMFVEPLIHKDDRTL-KEK---LKAKSDSGVPSGTEEITDSMKILNLFEK-HSTLET

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

H
TVLLVGMPGTGKTMLTRRICYEWATRELSQFTLTFLFEFRQLNLIHRYVTLKELLFNLFL
KPDGN-PEEVYQYIIENPQHILIMFDGLDEFIGQISHDPPQ----VNPEADKPVSISELF
TCLLHGVILSGCTVVVTCRSKILNNIPLKTIDLVAEVLGFNQGRVEKYVKLFFRNDY-LR
EKVLLHLRENTKLMHMCFVPALCHIVCICLEYLLQ-----APSSAQLPQTITQFYVVMLN
IFIAKEK-------------FKPLITELCDLALKGLDEKKTVFYVE-DISKGLQGFAPCH
GLLSVFDV----------------------------------------------------
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----------------------MDS-SLQN---DGSLNHLVGLLSEDLEWLP-RPKFFMP
DIDLTPMDEAPDP---TQKVSLVLSKLEAHGSSTWRTFIDCVCMEHTMPLDLETMFLSIW
GIDSXXXXX---------------------X---XXXXXXX----XXXXXXXXLKRP---
-PLRGSSPRPK-WSRRQQL----ESVRRYEKLLRTLLLQRYGSTHKR-TTVPHQRQPF-S
FSQTYVDLVVRRGKVTWLKENPEKPQGDALSEPLEGEDG--TNLKVQDLFKG-QSGAGT

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

K
VTVLLGKPGAGKSMLMHRICQKWANGELDQFSKVFLFEFRQLNLVKQELTLSQLLFELYL
SPEDE-RDAIFQHLQENAHRVLLVFDGLDEFLFPWPRG------PDSLDPTLSLPVATLF
SRLCSGSLLPGCWVVTTSRPGKIPDFLLETATSVFEVWGFDSLQIEKYVSNFFHG

ENSGT00860000133673_1_Linker_0_1 (476, 828)

LT-FR
DMALAQLRDNTQLQSLCSIPALCCIICICLYHLAS-----EQ-SINF-LNITQVYMQMFH
IFSLGQS-----------LLASQALLGLGELALRGLMAKQIVFYPG-NIPERVVAFAATH
NLLASFRVKTGIQQQKTCYAFVHLSLQEFFAALYLMVSPNINKTELSCHFFLKSKWPLRT
--EAKTEL-LDRFHTFLSGFSSQTCQSFLSQLSQQDEAWVGTKQVVIRQVLQGLAARSLT
GPKMIELCHCVEETQDAELVKQAGRHLPFSLDFHNFPLNYSDLAALTSVINHAPASIHLD
FSGCSLEPQCLNALAGCEKIESLR-VRSRKCRDAFAEALSRTLPTMG

PF00560 // ENSGT00860000133673_1_Domain_1 (828, 854)

NLKKLELTGNNIS
VRGIGHLAQAFIDCH-LEEINLQDNRLNDLSCLKIIEILHKMERLQKIDLSRNAVSVLTV
LALVKEAVYYPRVTTLEIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXLSGNQLEDEGCRELAEALSDLHIAKQ
FXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXLKNKTAILRFAWDQEEKDQVQCXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX--------XLS
NNNLGNRGIEKLTHLLPGLKSLQFLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX---XXXXX------XXXXXXXXXX--XXX-XXXXXXXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXFSHVTMSDQ----SIEMLVDYLPQLHNLNLLQLSQIT
LS---LNSVFLLAGAI----SL-C--EQIQKVEVS--------------------R-LTG
CCISPVDMEQLCCILG-QC-KD-----

PF00560 // ENSGT00860000133673_1_Domain_9 (1408, 1438)

-LSHLDLSGNL----LGDEGLKYLLE---HLPQ
MNLSGSLNLSHNAISKEGALLL---LPSCTQAHE-VSLSLDPEEKFLIQFSEHQEP-RKT
L--XXXXX-XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX--XXXXXXXX
XXXXXXX-XXXXXXXXXXXXX----XXXXXXXXXX-XXXXXXX----------X-XXXXX
XXXXXXXXXXXXXXXXXX-X-X-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-------XXXXXXXXXXXXXXXXXLTASTMSPAGVCQVASGLSHCNTMEEL
XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXL
-------------------------------------------------SNSGL-SSIGC
SYLSDSLRDAA

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

NLQDLNLSRNKIEDAGVQHLSAILPT

ENSGT00860000133673_1_Linker_14_15 (1898, 1900)

LL

PF00560 // ENSGT00860000133673_1_Domain_15 (1900, 2015)

QLRKI----------------
------------------------------------------------------------
-----------------NLSSNSISPVGGKKLAEALALCVHVEELHLGSNAMGDLVAIKL
AQNLPH--HLKVLQ---------LCCN--QIGTKGTLSLCQALTRCQWIKEISLAENIFA
EGILPLS----EGLLKLRK------INLTSCNINDQMTKPLASSLILCHDLEEILLAWNC
LGNEGATQLALVLPRMN

PF00560 // ENSGT00860000133673_1_Domain_22 (2178, 2196)

QLKKLDLEGNHIGSLGAQLLAKGLAKGPGIQIIRLWKNPVPKD
TAQLLQGQDPRLDFSNQLQDS-------

----------------------NDDLNLEV-AIASIRPQLVEFLSHHQDWLLTTSQHFLP
GATLRDLDGITDH---REKVSELLDLLEKDGPDTWKQFVQHLCMELDLPLELEILLMSSA
EYQSTGLHS--------------------------QLGNAGSDSPKMLTLHVCMYPTEEC
F-TP---PVKA-ECKEQTL----NSAANYRHLLIDTVRQRYGSRRAAGAAAQEQMQPL-A
FNQAFVNLVIRQSKASRLKERTDKPRED-LPSAPEPEECVDTAMRVSDLFSSAVRSGTT

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

K
LIFLFGRPGTGKTMLMHRICQKWAEGVLHQFLFTFLFEFRQLNLLKRKLTLKELLFDLFL
QPEES-PDAVFQHLLENAQHTLIIFDGLDEFTGSMDMSSTS---KEGPTLPSHMSISELF
ADLCHGKLLPGCTVLVTSRPKRLPDFLLNTVDVLAEVWGFDHKKVEEYVSHYFHHHS-FK
EQAIAHLKNNTKLLSMCLIPALCYVVCICLEYLLLK----HQMSVELPQTMTQFYIKMLL
IFINKQQGEHAVDEETQLNCNKKAILGLCDLALKGLEDKKLVFYVS-DIPEDVKEFASLH
GLLTVFEVKTSGTHPEAGYAFVHLSLQEFFAALCLMINKRVDKSYLKKKFSLKSKWTLKN
--EAKTEF-IESFHIFLSGLSSKECRTFLMLLAEQNEAWVQDKQDAILQSLKKLAATHLT
GPKVIELCHCTFETQDLKVAQHIGSLLNFKYEFKNFRLTPLDMSALVFVINSGQDLTHLD
FAGCLMDAGCLEVLASCKNVEHLS-FRSRRFGDDFAAALSKSLREMGSLKKLELTGGNIT
AEGLTNLVQASSQCL

PF00560 // ENSGT00860000133673_1_Domain_2 (856, 878)

QLEEINLQDNRIRDLEVKRVLDLFSRMEKLKKVDLSNNNLSLNAV
LILAKEVVTCQNATELHVRYQKDIVIINF-SGTSGKVQRSLDLRWEENKECVIP-TRHMK
LC----LQDRGLSLQHAKEIVSILQSCPHLSEVDLSGNKLGDEGCSCLLESLPWISISKQ
LDLSHNLLSINGIYSLLKSVNTCQKTME-VEVSLCHKTAVLRFTEDKEFAS-PH-REEPL
YP--TDDQQVGEEKQTPTLSKKIRLTDCYFQAS-DLEKLCAVLKECSSISE---LDLCLS
NNSLGDEGLSRLFQFLPNLKMLRSLKLDNNRISLNSVFCLAQSLSTLERIKTMNLRYDQE
YFSFCGATRGSQ---SYPR-------GSWVNNIPSL--DRLGMLQVYMPASLCLGD--CT
MGPEDVTRLCQILVHCT

PF00560 // ENSGT00860000133673_1_Domain_8 (1278, 1305)

QLTEINLSGNPLSDQ----SIERLLSF

ENSGT00860000133673_1_Linker_8_9 (1305, 1402)

LPYLCHLTLLSIKNST
FS---PRCAILFTNSI----GL-C--ERIRKVEVRSNQNAFLHLGTSTHSQKTSCRCLTD
CAISQGQIEELCGVLE-Q-HG

PF00560 // ENSGT00860000133673_1_Domain_9 (1402, 1438)

RL------AEVDLSRNQ----LGDEGLRFLLD---HLHR
VHVTCSLNLSHNRISQDGVLHLINAFATSGNVTE-VLVSLCSKATLLMELTSRDDP-RKI
L--SLTEC-NFQAEHLEKLWLVLEKCTS--LTEYIWVTSSLLLPKCV---FLEPQGQGSF
SLLIKEPWVCKKSVMNLLEL-----AVQACGNITA-ITICKDK----------SLFQLGV
SFPCCLEKVESVVS---------------RLNLHEPEIKRACFYQRVLEKCIQLQELRWS
HVELHDDDT-------KILVTVLLPLPKLKKFELTSCSIMPTGIDYLITGLQKCQAIEEL
SPCTAVFCS--KCFHSCPWVISCSCVILSFSLGHMKLSDAAIPMLVLGLCKMP

PF00560 // ENSGT00860000133673_1_Domain_13 (1794, 1870)

SLKRLIL
-------------------------------------------------NHNSI-GNDGC
SRLAEALRNMHCMEEINLAHNKIGDPGLINIATVLLEMQNLKRI----------------
------------------------------------------------------------
-----------------NLSGNSPSPTGGEKLMEALACCKHIEELLLSRNVFGDGVAVKL
ALCLPHVSSLKILH---------LQKN--NIGPTGGTELARALVACRLLEEISLSENDLG
EGSIHALSEGLPRLEHLRK------IDLKLCGITDDSSKSLSCAFQQCPAMEEIILSWNS
LGDGGAQELASALPGMEKLKMLDLEKNRIGARGAVKLSEELVKCPEIQFIRLWENPVPKG
LAADLTSQDPRLCFSFY-----------

----------------------MDLLNMQL-GTSNLFSSVVTLLSKHAEWLTAKVKFFVP
HVDLGPRNESPDP---AQHIVRQLSRLSAQGLDTWQAFVHCVCMELDVPLELEMSLLSTW
GQE-DGL---------------------------PHHRGSDEESCPESQPRHGLKRP---
YHSCESSPHRKKQYKEQQL----ESARPYLRLLRTSTQQRYDNEHP------RPGQPR-S
FH---VAPILH--RVPAPLDTQEQAI---M-GDLEAEDG------IRDLFHP-SSGKGR

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
VTVVLGKAGMGKTTLSHWLCRKWAGGQLERFEALFLFEFRQLNQISGPLTLLQLLFDLGP
RPESG-ADSVFRYLQEHASRVLLIFDGLDEALWP-------------VDPNAPLPAFALF
SGLCNGTLLPGCWVLATSRPGKLPECLPVEA-AMVHMWGFDRPRVEEYVGRFFQGQSLLQ
AAALAEVRADGRLWSMCAVPALCQVACKCLHH-LLLDAPPGQAAT-LLPTVTQLFVQRVR
TLSPK------------------FLLDLSDVALQGLRAGKVVFSAG-DIPPAMLAFGATQ
SLLTSFSVRTGPGRHQTGYAFAHLSLQEFLAALQLMVSPRVDTDSLSGYITLHSHWTLRT
--NASLGLL-DHLPTFLVGLASSACRPFLISLVQQGSEAVAAKQTAVVQTLMKLTTRRLR
APKFMQLCHCVGETQEPELARLVAQNLPCPLSFHNLPLTYTDLAALANILSYRAAPIHLD
FEGCPLEPHCPEALVGCEQVEHLXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXLQNNQLKDREVLDVMRLLPGLPRLQRLDLSRNTVSESGL
LSLIKVVVMCPAIRMLQAGQEELILRFSPSPETTSELHGXXXXXXXXXXXXXXXPTRSWT
LS----PQKRQLRVHHMETLSTLLRGGP

PF00560 // ENSGT00860000133673_1_Domain_4 (989, 1015)

CLEEVDLSGNQLEDEGCRLMVEAASQLHIARK
LDLSDNGLSLHGVHSVLRELRSCWTLAD-LHISLLHKTAVLTFAQDLEEEEEEAGTQHRA
AFLDTLIP--HMPSELPLSSRRIXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXLS
DNALGDEGADILAQLLPCLGTLQSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX--XXXXXXX-XXXXXXX------XXXXXXXXXXX-XX--XXXXXXXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXLSCEPLSDQ----SLETLLDCSSRLPQLSLLQLSHTE
LA---PTSALLLANVF----HL-C--PRVQKVELRSLHHVSQHFKSQEEQGGVNCGRFLS
CRLLPEHVKPLCLLLS-KC-ED------VSQLALSGNL----LGDEGFKRLLE---GLPR
VPISGVLDESHNNLSLESALLLLETLPSCPRARE-ASVNLGTEHSFRIYFSKQEEA-RKV
L--RLNGC-SVLPEHVPRLASGLSQAPQ--LTELTLTRCGLDLGQLTVLLSLVRRPAGLL
CLXXXXXXXXXXXXXXXXXX-----XXXXXXXXXX---XXXXX---------XXXXXXXX
XXXXXQGSQEAMAL---------------RLAPCDFGNPHSLPVRVPMETYARLRRLXXX
XXXXXXXXXXX-----XXXXXXXXXXXXXXXXXLTSSYVSIEGLTHLASGLSHCQDLELX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-----------XXX-XXXXXX------------
----------------------------XXXXXXXXXXXXXXXXXXXXLSENRI-NDVGC
RDLAEALRGATNLEDLGXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------
------------------------------------------------------------
-----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLETNALRDLTICML
ARELPP--HLRALY---------LSSS--CLSPEGVLPLGQALDGCPHMEEISLAENTLG
QGLSWFS----KGFPLLRQ------IDLISCKIDNQAAKPLAAGFLLCPALEEI------
------------------------------------------------------------
----------------------------

----------------------MDDVSRQR-AIDDAWPQLVDFLDQYPEWVLRKARQLLP
QRDLSCVEDLADPKEKVSLVLDAFRTAAEANPPAFKGFVQSACMEFNLPMEIEITFMSIS
AEAGNMA----------------------------QEQEFEDAASPSPS-TSARFERRRP
WSSPSAKHNCK-ASKQQRL----DSAERYRQLVVQHMRQRYGTSGP------FQDQPS-A
FNQAFINLVIRHCKALKLKGRTEKGVKEEHTCLHDMEEHGNVTMRLSDLFDS-VQTETTK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 475)

VILLLGRPGMGKTRLMHKICQQWAEGNLTQFQLIFLFEFRQLNLIKRKLTLQELFFGFFL
QPDSC-PDAVFEQLQEDARHILVIFDGLDEFVENIELSSSP--CVPSPDLFDPLSTAELF
VSLCYGKLLSGCTVLVTTRPKVIPESLSKVRTLLAEIWGFDREKVEEYASYYFRHNS-EK
EQALAYLKSNGKLLSMCYIPALCNIVCICLEYLLLQ----NPGSNQLPQTVTEFYIQMLS
TTICKH-----RDKEEHLGQHQEALLGLCEWAFKGLEQKKMLFYAG-EVPEQVIL-----
--------------------------QEFLAALFLLTSKNV-------------------
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----------------------MDPESLQL-GTENLWAWLVRLLSENSAWLDAQVRFYLP
TVDLDSSSKVPDP---EI-IRHQLRRLYTQGLETWQSFIYSLCMELTVPLDLEVPLLSIW
GQK-DEF---------------------------SKQIGAGEDSHPGPPLHHGVKRP---
SQSCGSSPRRK-HCRKQQL----ELAQKYLKLLKTSAQQYHGGVCM------GAGRPQ-A
SPLAYVPPILQWSRAAAPLDAQEGAT---I-GDPEAADD--VDVSIEDLFNF-RAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCWKWANGQLDRFQALFLFEFRQLNTITHLLTLPQLLFDLYL
SPESE-SDAVFQYLGKNAHQVLLIFDGLDEALHA-----------GSMGPDDAGSVLSLF
SGLCRGTLLPGCWVMATSRPGKLPACVPTEA-AMVYMWGFDGLRVEKYVSHFFSDLL-SR
ELALAEVRSNERLRGMCAVPALCRVACFCLHR-LLPGSPPGQSTA-LLSTVTQLYLQMVE
TFNPNG------------TLPATSLLDLGKVALRGLDTGKVIFSMA-DIPPPLMAFGAVH
GLLTSFCIRTDPEHQKIGYAFAHLSLQEFFAALYLMASDTVDKDTLICYVTLNSHWVLRT
--KARLDL-SDNLPTFLAGLASHTCRPFLCHLARQDEAWVGSRQAAVVQVLKKLASRKLT
GPKMIELCHCVAETQELELARFMAQSLPFQLSFHNFPLTRADLAALANVLEHKAAPIHLD
FDGCPLEPHCPEALIGCGQVENLS-FKSRKCGDAFAETLSRSLPTMESLKTLGLTGSKIT
ARGISHLVQALPLCSQLEEVSLHDNQLKDPEVLSLVELLPCLPKLQKLDLSRNSFSMSTL
LSLVKVAFTCPTVRKLQVRESDLIFLLCPVTETAVRPSGASNLQDKDS-LK-KGQNRSLE
LR----LQKCQLRVHDAETLVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

RLEEVDLSGNHLEDEGCRLVAEAASQLQIAKK
LDLSDNGLSRTGVTYVLRAMSTCGTLEE-MYISLLSNTVVLTFAQEPR---EQERSWKRD
APLTSFVC--PVASEMSQSSRRIRLTHCGFLA-KHTERLCRALSASCQLH

PF13516 // ENSGT00860000133673_1_Domain_6 (1131, 1152)

RL--DHLDLS
DNSLGDEGVALLVQLLPGLSPLQSLTLSRNGVSLDAVFGLIPCMSSVPWVFHLDVSLESD
HI---VLRGAGT-DRDALAG------RCGPGFPAGAPELE--FSPRYSSRSFCLQG--CQ
LEPRSLACLCAPLEKCPGPLEVHLSCKTLSDE----SLKTLLECLPKLPQLSLLQLNNTV
LS---SRSPFLLADVF----NL-C--PRVQKVNLRSLCHADLHFGSKEEQEGVCFG-FPG
CSLGQEHMEPLCGALS-RC

PF13516 // ENSGT00860000133673_1_Domain_9 (1400, 1431)

-TV------LSQLDLTGNL----LNDSGLRCLLE---CLPQ
LPISGWLDLSHNSISQEGVLCLLETLPSCPRVCE-ISVSLGSEQSFRIRVSKEEEA-WTT
L--RLCEC-SFSPEHVSRLASSLSQAQQ--LSELTLTRCHLDLPQLIHLLNLVNRPAGLL
GLRLEEPWVGHVSLPAVMEV-----CAQASGRLTE-LSLSETQ----------QQLRLQL
EFCHQEDKSEAMAN---------------RLAHCDLRTDHSLLMTQLMETCARLQQLSLS
QVNFSDDDD----TRSRLLQNLLLSSCELKSFRLTSSCVSTESLTHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1748)

HCQHLEEL
DFSNNHL

ENSGT00860000133673_1_Linker_12_13 (1748, 1793)

SE--ENIELLMGALQGTRRLKKLHLGHFPLEASSLALLIQGLSHM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1891)

TLLQHLSL
------------------------------------------------------------
------------------RHNQIGDVGTQN

ENSGT00860000133673_1_Linker_13_15 (1891, 1901)

LAAILPRLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKL----------------
------------------------------------------------------------
-----------------DLSGNSIGPAGGVPLAKSLTHCRCLEEIILGNNALGDPTALGL
AQRLSP--QLRVLC---------LPSS--HLGPEGALGLAQALKQCPHIEEFSLAENNLA
GRVPYFC----KSLPRLRK------IDLISCKIDDQAAKHLATSLMFCPALEEILLSWNL
LGDEVAAELAQVLPQMGQLKRVDLEKNRITACGAQLLAHGLVQGSCVPVIRLWNNPIPAD
VAQSLQSQEPRLDFAFFDQQPRAL----

----------------------MDPIDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPESRLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
LHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-ATVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLKAVSACWTLAE-LHISLRHKTVIFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLNQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MKALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRILH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-PKSG-AD

PF05729 // ENSGT00860000133673_1_Domain_0 (369, 476)

TVFQYLEENAHRVLIIFDGLGEALYPCSSR-------KTEGPDASGPIFTLF
SGLCNGTLLPGCWVMATSRPGKLPTCLPVEA-TMVHMWGFDRLRVEEYVGRFFRDNP-LQ
AAALAEVQADRRLQSMCAVPALCQVACLCLHH-LLPGTSVGQSAA-LLPTITQLYVQMVL
ILIRQS------------HLHPTSLLSLGEVALKGLEAGKVVFYAG-DIPPPMMAFGAAY
NLLTSFCVRTGPEHQETGYAFTHLSLQEFFAALQLMASPEVDKDMLPRYVTLHSRWVHRT
--NARLDLLD-YLPTFLAGLASCACRPFLSHLAQQDEVWVGAKQDAVVQALRKLATRRSK
GPKVMELCHCVDETQEPGLAQLAAQSLHYPLSFHNFPLTYTDLAVLANILGYRDAPIHLD
FEGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAEALSRSLPTMNSLQKLGLTGSKIT
SKGISCLVKALCLCPQLEEISLRNNQLKDQELLDIVEMLSCLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 900)

RLRKLDLSHNNVSVST

ENSGT00860000133673_1_Linker_3_4 (900, 989)

L
LSLAKVVVTSPTIRALQARQTELIFLLSPSTETAAELQGAPDLQRNAR-QREEAQTRN--
LR----LRKCQLRVHDVETLIALLRDGP

PF00560 // ENSGT00860000133673_1_Domain_4 (989, 1015)

CLEEVDLSGNQLEDEGCQLMAEAVPQLHITRK
LDLSDNGLSALVVHCVLSALSTCRTLAE-LHISLLQETVVLIFAQEPE---EEKGTQKRA
AFLDNLMP--QMPSELPPSSRRIRLTHCGFQA-KHLEQLCKALGGTY

PF00560 // ENSGT00860000133673_1_Domain_6 (1128, 1159)

YLSH---L--DLS
GNALGDEGAALLAQLLPG

ENSGT00860000133673_1_Linker_6_7 (1159, 1161)

LG

PF00560 // ENSGT00860000133673_1_Domain_7 (1161, 1187)

TLQSLNLSENGLSLDAVFSLVQPFSTLEWILHLDISLESQ
CF---LLRGDRR-RRDALAG------GSLPECPAGAQFLG--FRQCCVPRSFRLRE--CQ
LEPSCLSRLCEALEKCPGPLEVELSCEVLSDQ----SLETLLHCLPWLPQLSLLQLSKTR
LS---PRSPLLLANIF----SL-C--PRVQKVELRYPHHVSLHFRSSEEQEGVDC-RFMG
CGLLQEHVEPLCWLLS-KC-ED------FSQLDLSGNL----LGDDGLRSLLE---CLPQ
VSISGSLDLSHNSMSLESALYLVETLPSCPGVGE-ALVNLGPEQSFQIQFSRQEEA-GKT
L--RLSEC-SFLSEHVPRLATGLNQALQ--LTELTLTRCGLGLEQLTILLSLVKRPTGLL
GIRYL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

----------------------MDPISLQL-GTRNLHGWLVRLLSRNLEWLDAKVKLFLP
NVDLGSEYQALDP---TQRAILHLQKLHTQGPTTWKSFIQCVCMELDVPMDMEVLLMSMW
GHE-DGF---------------------------PSLLEIGKESRSDSQLHPGLKRT---
YQSCGSSPRRK-QLRKQQQ----ELPKRYLQLLRTSVQQRYGDRTP------GLGQPL-A
FHQVYVPPILQWSRASAPFHTQEGAT---T-GDPKAEDG--TNVNIRDLFST-KASKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHWLCQKWADGELDRFQAVFLFEFRQLNLITGSLTLPQLLFDVHL
RPEAS-PEAVFQHLKENAEGILLIFDGLDEILQPCSDK-------ETADPEDPASALTLF
SRLCRGTLLPGCWVMATSRPGKLPACLPTEA-ATVHMWGFDGPRVEEYVNHFFSDQL-SR
EAALAELRVDRRLWSMCAVPALCQVACLCLHH-LLPGRSPGQAAA-LLPSMTQNYVQMLL
ALDPRG------------VLQAEPLLGLGEVALSGLESGKVIFSTG-DIPASTLAFGDAL
GLLTSFCVCTGPGHQDKGYAFSHLSLQEFFAALHLMTRPQVDREALSQHVTLHSRWVQRT
--KARLGLSD-HLPTFLAGLASRACRSFLSLLAQREEEWVAARQEIVLQALKKLATRRLT
GPKIVELCHCVGETQEPELASFMAHNLPQQLPFHNFLLTYADMASLTNILGHRDGPIHLD
FEGCPLEPRCPETLAGCGQVENLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
AQGISHLVQALPFCPQLEEVSFQDNQLKDKEVLNIVKVLSCLPRLQKLDLSRNNVSVSTL
LSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETAAELQGDPDLQGNAN-QRKEAQRRSLA
LR----LQKCQLGVHDVEVLIAQLQEGPQLD

PF13516 // ENSGT00860000133673_1_Domain_4 (992, 1008)

EVDLSGNQLKDEGCQLMAEAAPQLHITKK
LDLSDNGLSAAGVLSVLSVVSTCQTLAE-LHISLLHKTVVFTFAPELE---EQEGIQKRA
TFPDSLTF--QMPSEPSLRSPRIRLTHCALQA-QHLELLCKALGGS

PF13516 // ENSGT00860000133673_1_Domain_6 (1127, 1153)

CRLGH---L--DLS
GNALGDEGVALLARLLPGLGSLQSLNLSENRLSLEGVFSLIQCFSTLRWLLHLEFSSASQ
HI---ILRGDKR-GRDLLAP------GSLPEFRAGAR-LG--FGQRHVPRSFCLKE--CQ
LEPLSLSHLCKSLEKCPGPLEVQLSCEVLSDQ----SLETLLHHLPQLPQLSLLQLSQTQ
LP---PRSPLLLADLF----SL-C--PQVQKVDLRSLRHLTLHLRSSEEQEDRCCWRFTD
CGLRQEHVEPLCCLLS-KC-ED------LNQLDLSANL----LGDDGLRCLLE---CLPK
VPISGSLNLSCNSMSQESVLCLVEALPSCPRVRE-ASVNLGSKQSFWIHFSRQEEA-GKT
L--RLSEC-RFKPEHMPRLAASLNQALQ--LAELTLTWCFPGLEQLIVLLGLLTWPTGVL
TLRVEEPWVGRARVLKLLEV-----CAQASGNITE-ISISETQ----------QQLCIQL
EFPHQ-ENPEAVAL---------------RLAHCDLGTHQNLLARQLMETCARLRQLSLS
QVNLCDASS-------LLLQSLLLSLSELKNFRLTYSCVSSKGLAHLASGLS

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1753)

HCHLLEEL
DLSNNQLGD--EGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRL
-------------------------------------------------SRSNI-DDVGC
CHLSKALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELSLSHNQIGNTGAQDLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGPAGGARLAESLTLCRHLEELMLGCNALEDCTALGL
AKGLPR--HLRVLH---------LPSS--HLSPEGVLSLGQALDGCPHVEEISLAENSLA
GGVPRFH----QGLPVLRQ------LDLVSCEIDNQAAKPLAASFVLCPALENITLSWNL
LGDEAAAELARVLPQMGRLKRVDLEKNRITAYGAWLLVEGLAQGSGIQVIRLWNNPIPPD
MAQHLQNQEPRLDFAFFDNQPQVIPRGT

----------------------MDPVDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPESQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQSH-A
FHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHITRK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLQHKTVVFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENSLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWTT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCG-FTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLWEDND-D--SS-LLLQNLLLSLSQLKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTVKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

----------------------MDPDSLHL-GSENLCGWLVRLLSTNQEWLRAKVKFFLP
DVDLASSNEALDP---EQRVVLQLGKLYTQGVATWQSFIHCMCMELEVPLDLEVPLLSTW
GQD-DEL-P-------------------------R-LLGTGEESRPGSQLHHGLKRP---
YQSCESSPCQK-HSRKHQL----ELAQSYLQLLRTSALQQYGDGLP------GPGK----
---VYVPPVLQWSRATVPLDTREGAI---M-GDLKTEDG--NDVSIQDLFNF-RTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARRLCHKWADGHLDHFQALFLFEFRQLNLIPHFLTLPQLLFDLYV
RPESG-PEAVFQYLQENASQVLLIFDGLDEALHLCSSK-------ETAEPNGSGSAFTLF
SSLCRGTLLPGCWVMATSRPGKLPACLPTEA-AMVHMWGFDWLRVKEYVNHYFSDQP-SQ
EVALKELLANGCLRSMCVVPALCQVACLCLHH-LLSASPTGQSVA-LLPTMTQLYMQMLL
TLSP---------------LPAMSLVGLGKVALSGLETGKVIFYIK-DIPPPMMAFGATH
SLLTSFSIHTSPGHQETGYAFAHLSLQEFFAALYLMTSPTVDKGTLTRHVVLNSRWVLRT
--KARLGL-EEYLSTFLAGLASHTCRPFLSHVAQQNEVWVATRQAAVVQLLRKFATRKLT
GPKVVELCHCIAETQEPELAGLTAQSLPDQLLFHNFPLTYMDLASLVSVLEHRAAPIHLE
FEGCPLEPHCPEALAGCGKVETLS-FKSRKCGDTFAEALSRSLPTMGSLKKLGLAGSKIT
ARGISHLVQALPLCPQLEEVSLQDNQLKDQEVLSIVELLPSLPQLQRLDLSHSNFSMSTL
FCLVKVAVTCPTVRTLQVREADLVFFLSPSTDTAADLQRAPDLMEKDS-QRKESQSRILA
LR----LQRCQLRVHHAEVLVGLLQKG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1009)

PWLEEVDLSGNQLEDEGCRLLAEAASRLHITRK
LDLSHNELSVDGVTYVLQAVNTCQNLAE-LHISLLQKTVVLTFAQDAK---EEEGTQERA
AFLDNFTS--PTASEPY---RGIRLTHCGFRA-KHLEKLCKALEGSCLL

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1153)

PHLGHL--DFS
GNALKDEGAMLLAQLLPGLGSLQSLNLSENGIALDAVFRLTQCLSTLQWVCHLEVSFESQ
HIL---LRGDKR-GRDKLAG------ESLPEFPAGAQLAG--FHQHCVPRSFCLKK--CQ
LEPLSLTHLCTALEKWSGPLEVKLSCETLSDQ----SLETLLHCLPRLPQLSLLQLSQTG
LP---LKSPFLLASIV----SQ-C--PRVQKVDLRSLRNATLRFRSSEEQEGVCCG-FTG
CSLRQEHVAPLCRALS-KC-DY------LCQLDLTANL----LGDDGLRCLLD---HLSQ
MPISGLLDLSHNSISQEGVLHLLETLPSCLRVEE-ASVNLGSMQNFWVRFSKQEEA-RMT
L--RLSEC-SFGPEHVVRLASSVSQALQ--LTGLTLTRCCLDLKQLTILLSLLRRPSGLL
GLRVEEPWVGGAGVPTLLEV-----CAQASGN-VTVISISETQ----------QQLYIQL
EFPRQEENPEVVAL---------------RLAHCDLGTHHSLLVRQLMETCRRLQQLSLS
QVNLCDASD----ATFLLLQSLLLSLCDLKTFRLTSSCVSTQGLTHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1748)

HCHHLEEL
DFSNNQFGE--QAEEILMGALEGKYRLKTLHLSHLPLGGPTLATLTRELSHMSLLQ----
------------------------------------------------------------
-HLC-------------LSHDQIGDTGAQNLAAILLGLPGLRKID---------------
------------------------------------------------------------
------------------LSANGISLAGGLQLAKSLTLCRHLEEVRLGCNALGDPTALTL
AQGLPQ-

PF13516 // ENSGT00860000133673_1_Domain_20 (2048, 2079)

-HLRVLH---------LQSS--RLGPEGALSLGRALDGCPHVEDISLAENKLA
NWVPRFC----KGLPLLRR------MDLGSCEIDNQTAKDLAASFMLCPALEEILLSWNL
LGDEAAAELAQVLPRLGRLKRVDLEKNWITAAGAWLLAKGLAQASGVHVIRLWNNLIPPA
VAQRLQSQEPRLDFAFFDNQPQGPRDT-

----------------------MDSDNLHL-SHENLCGWLVRLLSTKQEWLRGKMKFFLP
DVDLASSDD-PGP---EQSVIRQLRALQAQGRTAWQTFIHCVCMELEVPLELDVLLLSTW
GQD-DGK-D-------------------------R-WGGHR--PISLPSLFAELKRP---
CQSCEFSPHKK-HCRKHQQ----ELAQRYLQLLRTSALKHYDDGFP------GPRK----
---VYVPPILQWNRATVPLDTQEGAM---M-GDPKTEDG--SDVSLQDLFNF-KTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKTGMGKTTLARRLCHRWAGGHLDHVQALFFFEFRQLNLITHLLTLPELLFDLHL
KPESG-PEAVFQYLEENASQVLLIFDGLDEALHPS-----------TVGSNGSGPVLTLF
SSLCRGTLLPGCWVMATSRPGKLPAYLPTEA-AMVHIWGFDQLKVEEYVNHYFSDQP-PQ
EMALTELLANRHLWSMCVVPALCKLVCLCLHH-LLSTRLPDQSAASLLPTVTQLYIQMLL
TCSP---------------LPATSLVGLGKVALSGLESRKVIFYDR-DISPPLMAFGATH
NLLTSFCIRTSPGHQEKGYAFAHFSLQEFFAALYLMTSPTVDKNTLARHVILRSHWVLRT
--EARLSL-EDYLPTFLAGLASHSCRLFLSQVAQQDETWVGTRQAAVVQLLKKLAARKVR
GPKVIELCRCVAETQDPELASLTAQSLPYQLSFHNFPLNYADMTTLTSVLEHRTSPIHLE
FEGCPLEPHCPEALAGCGQVEVLS-FKSRKCGDTFAEVLSRSLPNMGSLKKLGLARSKIT
ARGISHLMQALPLCPQLEEVSLQDNQLKDQEVLSIVKVLPSLPQLQKLDLSHSNFSISTL
FLLVKMAVTCPTVRTLQ---AELIFLLSPSTEMATLCL-------------------HPS
SR----LQKCQLRVHNAEDLIGLLRKGPP

PF13516 // ENSGT00860000133673_1_Domain_4 (990, 1009)

LEEVDLSGNQLEDEGCRLLAEAASHLHITGK
LDLSNNELSADGVPHVLRAMNTCRSLTE-LHISLLQKTVVFTFAQETE---EQSAPLVTF
P-------------WLP---KPQQLTHCGFQA-KHLEKLCKALEGNCHLS

PF13516 // ENSGT00860000133673_1_Domain_6 (1131, 1151)

RLGHL--DFS
GNALRDEGAALLTQLLPGLGPLQSLNLSENDLSLDAVFCLTQCLSTLQWVCHLEHGIQRK
CLELAFWHGLST-SRAK-----------LAGLPVGAQFLG--FHQHCLRRSFCLQE--CQ
LGPPSLIRLCTALEEWPGPLEVQLSCKALSDQ----SLETLLHCLPRMPQLSLLQLSQTS
LP---LKSPFLLAGII----GQ-C--PRVQKVDLRSLQHATLHFRSSKEQEGVCCG-FTG
CSLRQEHVESLCQALS-KC-DG------LCQLDLTANL----LGDDGLRCLLD---HLSQ
MSISGLLNLSHNSISQEGVLHLLGTLPSCPHIQE-ASVNLGSTQNFWVHFSKREEA-GMS
L--RLSEC-SFGPEHVPRLASSISQALQ--LTELVLTRCGLSLKQLAILLSMVRRPSGLL
HLRVKEPWVGEAGVPAVLDI-----CAQALGN-ITIIGISETQ----------QQLSIQL
EFPHQEENPETMAL---------------RLANCDH-----SLVRQLMETCARLQQLSLS
QVNLCDGSS----ATSLLLQRLLLSLCELKTFRLTSSCVSTQALTHLAAGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1748)

HLHHLEEL
DFSNNQVGE--QSTEALVEVLKGKFRLKSLHLSQLPLGGSTLVTLSQGLSHMSFLQ----
------------------------------------------------------------
-HLCNG-SDSLALLSPS

PF13516 // ENSGT00860000133673_1_Domain_14 (1878, 1892)

LSHNQIGDAGAQHLAAILPRLPRLRKIEI--------------
------------------------------------------------------------
--------RRSGDHPSHSLSANGISTAGGLKLAESLTLCRYLEDMRIGHNALEDHTALRL
AQGLPE--

PF13516 // ENSGT00860000133673_1_Domain_20 (2049, 2079)

HLKVLH---------LQSS--HLGPEGALSLGQALDGCPHVEDISLAENKLA
RGVPHFC----KGLPLLRR------MDLGSCKIDNQTAKSLAVSFVLCPALEEILLSWNL
LGDEAAAELAQVLPRMRQLKRVDLEKNRITAAGAWLLAKGLAQGSSVPVIRLWNNHVPPA
MAKHLQSQEPRLDFTFFDNQ--------

----------------------MDSLSMQE-DGESLHHHLVGLLSEDFEWLISKAKFYLP
GLDLAPVEKVPDL---NQKVDLLLRHLRSHG-SIWRSFIDCVCMEHTMPLYLETMFLSVW
GTSSEAPNQ---------------------N---NYLQNSEDTLAKSQLLHSGLKRP---
STEKGSSPCRK-WSKQQQL----ESARSYERLLRVCLQQRYGSAQTR-AAMPRQGRPF-S
FSQTYVEPVIRRGKVAWLKENPEKPQGD----APEGDDG--ANLKVQDLFKS-HSGTGTK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 474)

VTVMLGKPGAGKSMLMHRICQKWADGELDQFSKVFYFEFRQLNLMKQELTFLQLLFELYL
SPEDE-PGAIFHHLQENAHQVLLVFDGLDEFLFPWPNKGPK--VD--LDPTQPVTVSTLF
SSLCNGSLLPGCWVVTTSRPGKIPAFLLTTATSVFEVWGFDWLQIEKYVSNFFHGLP-CQ
DMALTQLRDNARLQSLCSVPALCCIICICLYHLLL-----QGNTMNFPTTVTQFYMQMLH
TFVSRKQGA-CGDKGTWLSKNSQAVLGLGELALMGLKTKRVVFYPS-DIPEQVLAFAATY
NLLSSFRVKTGISQQETCYAFVHLSLQEFFAALYLMVNPTTDETELRRHFFLKSKWSLRT
--EAKTEL-LDQFHTFLSGFSSQTCQAFLSQLSQQDEAWVGTKQAAIRQVLQRLAARSLT
GPKMIELCHCVVETQDLELVKQASKHLPFSLDFHNFPLTHTDLAALTSLINHAPTSVHLV
FSGCSLEPRCLDALADCEKIESLS-VRSRKCRDAFAEALSRTLPTMGNLKKLELTGNNIS
VWGIDHLVQAFTDCLQLEEINLQDNRLNDPACLRVIKSLHNMHRLQKIDLSRNSVSVQTV
LALVKKAVSYPQITTLEIRQAQIIIHFSESLGKALEMSRLQKEKKNEPQDKMVTQDRKLI
FR----LQKCGLAIHHAKEIAEMLKHRPFLEEVDLSGNRLEDEGCQKLAEILPDLQITKQ
FNISDNGLSKTSVYCLLTAANACKNVME-LDISLKNKTAILKFAEDQEKAQTQSRTTVSV
TQPSK-NSPKLPSL----SARMIRLRHCGFHSK-DLEKLCGELSNCSHL--------DLS
NNCLGSKGIEKLTHLLPGLRSLQLLTLNENRTSLEAVFCLASTFSNLEWIYEVDISLGRQ
QSIHVKCFGRAR---EQSTT------GHWTKQNTQQ--ESL-ERIAHFPKRFCLRE--CQ
MEPPDLKKLLQILKTCHGCLEIKFSHVIMSDE----SIEELLNHLPQLHSLNLLQFSQTN
LS---QKSTFLLASAV----NL-C--KQIQKVEVRYVEFACLNFTPGR-RKGVSCG-LS-
-----------------------------------RNL----LGDEGLKYLLE---HLPQ
MNLSGSLNLSHNDISWEGAMRFITALSAWRQVHE-VSVSLDPEQRFLIQFTEHPEA-RKT
L--RLTRF-SFQQEHIAKLATLVGQVPK--LTDLILTDNTISLEGLQLLLNLVKMPSAIL
RISQGSY-TERKKMAFLQSYLGTVLGVIWHTVLLS-SSISRQE----------LLLQIEE
VFSGETENSGATTF---------------RFTQDDLGASQTFVIRWVVEKYIRLQELSWS
QVHLCDTST-------QLLKTLLLSLLELKKFRLTDSSMSPVGMCQVASGLSHCHTVEEL
DLSNNEFSV--EGTRVLMGALEGKCQLKNLNLRSLQLDEMALDVLSQRLQRMPLLQRLDL
-------------------------------------------------SNSGL-SSISC
SCLSDSLRNATNLEDLHLSHNKIEDAGVQCLAAILPRLPQLRKI----------------
------------------------------------------------------------
-----------------DLSWNGISPEGGRRLAEALALCHRVEELHLGANAMGDLMAMEL
AQNLPR--HLKVLY---------LCFN--QIGPEGTLSLGQALAKCHCIEEISLAGNIFA
EGFLPLS----KGLLKLRK------INLTSCKINDLMAKSLASSLVLCHDLEEILLAWNS
LGNEGATELAHVLPQMNQLKKLDLEGNQIGSLGAQLLAKGLAEGPGIQVISMWKNPVPED
IAQFLQGQDPRLNFS-------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LKRPHQSCG---------SSPRR---------KQCKQQQLKVYLYT-ENPSSVKTFIPPL
NLLTSFCVRTGPGHQVPDSVFAHLSLQEFFAALHLMTSPQVNKDMLAHHVTLNSRWVLRT
--KARLGL-SDHLPTFLAGLASCACRPFLRQLAQQEESWVGTKQATVMQVLRKMATHRLT
APKVVELCHCVYETQDPGLADLAAQSLRYHLPFHNFPLTYTDLAALTNILKHREAPIHLD
FEGCLLEPHCPEALIGCEQIDHLS-FKSRKYGDAFAEALSRSLPTMGSLQKLGLSGSKIT
ARGISHLVQALPLCPQLEEVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXESDLIFLLSPPTKTAEEPQRTSGQQESDS-QRKEAPGRSLT
LR----LRKCELRVHHADALTVLLHKSPHLEEVXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXX
XXXXXXXX--XXXXXXXXXXXXXXXXXXXXXX-XXXXX-XXXXXXXXXXXX---XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSLDAVFSLAKCFSTLRWVFQLDISLESQ
HI---LLSGDKRSXXXXXXX------XXXXXXXXXXXXXXXXXX---XXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXLSCEVLSDQ----SLETLLHHLHRFPQLSLLQLSQTG
LS---RRSPFLLADTF----GL-C--PRVRKVDLRSLQHATLHFSSHEEQDSVCCGRFTS
CDLGREHVKTLCQSLS-TC-KD-----

PF00560 // ENSGT00860000133673_1_Domain_9 (1408, 1438)

-LKQLDLSSNQ----LGDDGLRCLLG---CLPQ
LPISGSLNLSDNGFSQESALDLVETLPCHPRVRE-ASVNLGSKQSCWIHFSKQEEA-GKI
L--RFREC-SFQPEQVSSLVIGLSQALQ--LMELTLSWCCLGLEQLTVLLQLVRRPQGLL
ILRVEEPWVGRTEVPALLEV-----CAQASGNVTE-ISIAKIQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVRQLMQTCA

PF07723 // ENSGT00860000133673_1_Domain_11 (1673, 1702)

RLRRLSLS
QVNLCDDDS----ASSLLLRS

ENSGT00860000133673_1_Linker_11_12 (1702, 1736)

LLLSLSELKTFRLTSSCMSTEGLAHLASGLGHCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1761)

HLEEL
DLSNNQFDE--EGTRALMGALAGKYRLKTLXXXXXXXXXXXXXXXXXXXX----------
---------------------------------------XXXXXXXXXLSESRI-GDVSC
CHLSEALRAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

SLEELSLSHNQIGDAGAQHLAAILPG

ENSGT00860000133673_1_Linker_14_15 (1898, 1900)

LP

PF00560 // ENSGT00860000133673_1_Domain_15 (1900, 2019)

ELRKL----------------
------------------------------------------------------------
-----------------DLSANGISPAGGVLLAESLTL

ENSGT00860000133673_1_Linker_15_20 (2019, 2049)

CRHLEELILACNALGDPTALGL
ARGLPQ--

PF07723 // ENSGT00860000133673_1_Domain_20 (2049, 2087)

HLRVLH---------LQSS--RLGPEGVQSLGQALDGCPCVEEISLAANSLA
GGVPQFC----KGLPLLRQ------IDLASCEIDNQTAKLLAASLALCPALEEIFMSWNL
LVYEKNAELFQTL-LMLQLKRLDLEKNQITARGAWHLAEGLAQGSHTPVI----------
----------------------------

----------------------MDPVSLQL-GTRNLWSWLVRLLSKDPEWLDAKMKSFLP
NVDQGSRHEASDP---EQRVIEQLSTLQAQGQATWESFIHCVCMELEVPLDLEVPLLSTW
GCE-DGF---------------------------SSQLAASEESCPESQLHHSLKRP---
HQSCGSSPHRK-QCRKQQL----DLAKKYLQLLRTSAQQHYDSRLS------GSGQPL-A
FHQTYVPPILQGSWTTAPLDTQEGAT---T-GDPEAQDG--TDVSIWDLFNT-RANKAP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
LTVLLGKAGMGKTTLVHRLRQKWAEGQLDGFQALFLFEFRQLNLVTSFLTLPQLLFDVYL
SPESD-SDAIFQYLEENADQVLLIFDGLDEAV-------------QTRGPDDPGPALSLF
SGLCRGVLLPGCWVMATSRPGKLPACLPTEA-AMVHMWGFDGPRVEEYASRFFSAGP-SR
EEALAELRTSGRLQSLCAVPALCQVACLCLYR-LLPGKASGQSAT-FLPTMTQLYMQMVL
TLTPCK------------CLPATTLLGLGELALRGLETGKVIFYEK-DIPQSTMAFGAAH
SLLTSFCVHTGSGHQQTGYAFTHLSLQEFFAALHLMASPKVDKDTLARHITLNSRWVLRT
--KTRPGL-SDCLRTFLAGLASCACRPFLSQLAWHDEAWVGTKQATVMQVLKKLATRKLT
GPKVIELCHCVDETQETELASLTAQSLPYHLSFHNFPLTCADLATLTSILEHREAPIHLD
FEGCPLEPHCPEALIGCGQVENLS-FKSRKCGDAFAEALSRSLPTMGRLQVLGLTGSKIT
ARGISHLVKALPLCPQLEEVSFQDNQLKDQVVLSIVEVLPH

PF13516 // ENSGT00860000133673_1_Domain_3 (882, 896)

LPRLQKLDLSGNNI

ENSGT00860000133673_1_Linker_3_4 (896, 990)

SVSTL
LCLAKVAVTCSTIRTLQVREEDLIFLLSPPTKTAAELQRAPDLQEGDS-QRKEAQRRSLT
LR----LQKCQLRVSDAKALIAMLQEGPL

PF13516 // ENSGT00860000133673_1_Domain_4 (990, 1007)

LEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSVAGVHCVLSALSMYGHLAE-LHISLLHKTVVLMFSQELE---EQGTPQKRT
MFLDSLMP--QMPSELPLSSRRIRLTHCGFQA-KHLQQLCKALEESCHPGHLSPF

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1152)

HLDFS
HNALGDEGAAL

ENSGT00860000133673_1_Linker_6_7 (1152, 1161)

LVQLLPGLG

PF13516 // ENSGT00860000133673_1_Domain_7 (1161, 1181)

TLQSVNLSGNDFSLDGVFSLAQCFSTLQWVFHLDISFENQ
HV---LLEGDNG-DRNKWAG------GSLPEFPAGPEFSA--LGQRCVPRRFCLTE--CL
LQPLSLTRLCTTLEECPGPLEVQLSCEVLSDQ----SLETLLHCIPRLPQLSLLQLSQTG
LS---PRSPFLLANIF----SL-C--PRVQKLDLRSLHHVTLHFRSSQEQEDVCCG----
---------------------------------LSANL----LGDSGLKCLLE---WLPQ
VPISGSLDLSHNSISQESALYLVETLPSCPRVRE-ALVNLGSEQSFWIHFSKEEED-GKT
L--RLSEC-SFSLQQVPRLATILSQSLQ--LTELTLTQCCLDQEQLTVLLRLVRRPTGQL
SLRVEEPWVGKASVISLLEI-----CAQASGNVIE-ISISRTQ---------QQQFCIRL
EFPRQEENPEAVAL---------------RLAHCDLETHHSLLVRWLMETCARLKQLSLS
QVNLYDDED-A--SS-LLLQSLLPSLSELKKFRLTSSCVSPEGLIHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

QCHHLEEL
DLSNNTFCQ--EGTKALMGALEGKCRLKRLDLSHLKLGGSTLALLTQGLSHMILLQSLRL
-------------------------------------------------SGNSI-TAVDC
YYLSEALRAV

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TTLEELDLNHNQIGDAGAQSI

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSRNSIGPAGGAHLAESLILCGCLEELMLGYNTLGDPMALGL
AQGLPQ--HLRVLH---------LPSS--HLGPEGALSLGQALDGCPRVEEISLAENSLA
KGVLHFC----KGFPLLRH------MDLVFCKIDNQTAKSLATGFTLCPALEVILLSWNF
LGDEAAAELAGVLPRMGQLKRVGLERNQITARGAWLLAKGLAWGSGIQVISLWGNPIPHD
TAQHLQSQEPRLDFTFFDHQPQAPRGT-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

PF05729 // ENSGT00860000133673_1_Domain_0 (362, 476)

PEDS-PDAVFQHLLENAQRILIIFDGLDEFAGNMDVSSSS---KGSLNRSSSMSISELF
AELCHGNLLPGCTVLVTSRPKRLPDFLIKTVDLLAEVWGFDHEKVEEYVSHYFRHHS-FK
EQAIAHLRNNTKLLSMCQIPALCYVVCICLEYWLLK----HQTSVELPQTMTQFYIKMLL
IFINKQQGGHAGDEEAQLNSNKKAILGLCDLALKSLEAKKLVFYVG-DIPEHVKEFASLH
GLLTVFEVKTNSARPETGYAFVHLSLQEFFAALCLMISKSVDKSHLKRKLSLKSKWMLRN
--EAKTEF-MESFHIFLSGLSSKECRTFLMLLAEQSEAWVQDKQDAILQSLKKLAATQLT
GPKVIELCHCTFETQGLEVAQHIGSLLNFKYEFKNFRLTPLDMSALVFVINSGQDVTRLD
FAGCPLDTDCLEILASCRNVEHLS-FRSRRFGDDFAAALSKCLGEMGSLKKLEVTGGSIT
AVGLTDVVQALSHCL

PF00560 // ENSGT00860000133673_1_Domain_2 (856, 878)

QLEEINLQDNRIQNPDVKTVMELFSRMEKLKKIDLSKNNLSLNAV
LLLAKEVTVCQNATELHVRKDTVII--Y-FSGTSGKVPRSLDLKWEQNKECATP-TRHLR
LC----LQARSLSSQHAKEIVSILQSYPHLSEVDLSENKLGDEGCSFLLESLSWISISKQ
LNLSHNLLSVNGIYSLLKAVNTCQKVVE-VEVSLYHNTTVLRFTEDGEFASPPPGLLHSQ
SV----------GILTQRKKSLLWLTDCHFQAS-DLEKLCAVLKECG

PF00560 // ENSGT00860000133673_1_Domain_6 (1128, 1156)

SISE---LD--LS
NNYLGDEGLAQLLQFLPNLKMLRSLKLNNNQISLSSVFCLAQSLCTLEHIETVDLRYDQE
YFSCHFLLSNTE---ALDFK------L-HPNSV------LLWLQLKVLSRQFNLRD--CT
VGPEDVTRLCRILTQCP

PF00560 // ENSGT00860000133673_1_Domain_8 (1278, 1305)

QLTEINLSGNALSDQ----SIERLLSFLPYLCQLTLLSIRNNT
FS---PCCAVLFANSI----NL-C--ERIRRVEVRSSQNAFLHLRTSTQSQKTSCR-LTD
CAIGQRQIQKLCRVLE-Q-HGWL------AELDLSRNQ----LGDEGLRLLLD---HLHR
VPITCSLNLSHNRISQRGVLHLINAFSTSGNTTE-VQVSLCSKATLIIKLTSRDDP-RKI
L--RLTEC-SFQPEHLEKLWLVLENCTS--LTECISSNNNVTVDAAEGLLRSLSKTSGPL
KIRLLPALQRRV------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

----------------------MDPISFRL-GTKNQWGWLVSLLSNDPEWLSAKVKFFLP
NIDLGSRNEAPDP---TQRVLLQLRELHTQGPATWKAFIHCVCMELEVPLELEVQLLSTW
GHG-DGF---------------------------PGPSETGAESPPEPPLHHGLKRP---
RQSCGSSPRRK-QFRRQQL---AELAKRYLQRLRTSAQQRYGGELP------GPGQPL-A
FHQAYVPPILQWSRATAPFSTQEGAA---P-GSPRAEDG--ADLSLQDLFGP-RADKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
VMVLLGKAGMGKTTLTRWLCQKWADGQLDRFQALFLFEFRQLNLLAEALTLPQLLFDLYL
RPEEG-PDAVLQYLERNAKGVLLIFDGLEEALHPHPRG-------ETAGPEAPGPALALF
SGLCRGTLLPGCRVMATSRPGKLPDCLPTEA-ATVHLWGFDGPRVEEYVGRFFSNQP-AR
EAALAELRANRHLRSMCAAPALCRIACLCLRH-LLPDLSPGQSAA-LLPTVTQNYVQMVL
ALSPRG------------YQPAEALRGLGEVALRGLETGKVIFSAG-DIPPAMMAFGAAL
GLLTSFCVCTGPRQQEPGYAFTHLSLQEFLAALHLMASPEVDKDALARHVTLNSRWLLRT
--KARLGLWD-HLPAFLAGLASSACHPFLCHLAERGEAWVGAKQAAVIQALKKLATRRLT
GPKVVELCRCVGETQEPELASLMARSLPCQLPFHNFPLTYADLAALTNVLGHREAPIHLD
FEGCPLEPRCPEALAGCGRVESLS-FKSRKCGDAFAEALSGSLPTMGSLKKLGLAGSKIT
ARGIYHLVQALPLCPHLEEVSFQDNQLKNQELLSIVKVLPCLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 906)

TLRKLDLSHNNVSMATL
LGLTEVAVTCPTIRMLQVREADLIILLSPPTETAAELPGSPALRGNAG-Q-KEAQSRSLA
LR----LQKCLLTVRDVEMLIAQLREGPLLEEVDLSGNQLEDEGCRLVAEAAPQLRIAGK
LDLSDNGLSVVGVPWVLKAVSTCQNLAD-LHISLMHKTVVLTFAPEPE---EQEGTQERA
AFLDSLTL--QMSSELPPCSPRIRLTHCGLQA-EHLEQLCKALEGSCRLGH---L--DLS
RNALGDQGAAQLARWLPALGALQSLNLSENCLSLDAVFSLAQCFSAVPWVLQLDISFESQ
HV---VLRGGRR-ARHLLAR------SPPPESPAQAQSSG--FGQRCVPRSFCLRE--CR
LEALSLTHLCEALETCPGPLEVRLSCVVLGDQ----SLDTLLGHLPRLPQLSLLHLSLEP
GGQPDKQSPKMFQTAS----SE-AGKSGGERWSLQFLEEASLISRATSPEGAQGCHRFMG
CGLSQMHVEPLCELLR-KC-ED------LSQLE---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

----------------------MDADSLHL-GTRNLWAWLVRLLSKHQEWLNTKMKFFLP
TMDLGFSNEVPDP---EQRVIQQLSKLHAQGLATWQSFIYGLCMELEVPLDLEVPLLSIW
GQE-DEF---------------------------STQLEAGEESQPGSQFHPGLKRS---
HQSCGSSPCRK-HCRKQQL----ELARKYLQLLKTFAQQRYGGKCL------GPEHTL-T
SQQAFIPPILQWSKATAPLDAREGAS---M-GDPGAADD--IDMSIQDLFNF-KAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTMLAYQLCRKWADGQLDNFQALFLYEFRQLNMITHLLTLPQLLFDLYL
SPESG-PDAVFQYLEENACQVLLIFDGLDEA---------------SVGADSVGSALTLF
SDLCRGTLLPGCWVMATSRPGKLPTCVPTEA-AMVYMWGFDGLRVEKYVSHFFSDLP-SQ
KLALAEMRTNERLWGMCAVPALCRVACLCLHH-LLPGSSPGQSAA-LLATMTQLYLQMVL
TFGSHR--------------TATSLLDLGKVALRGLDTGKVIFSAE-DIPPPLMAFGAAH
SLLTSFCICTTPEHQETGYAFAHLSLQEFLAALYLMASDSVDKDTLIHYVALNSHWVLRT
--KARLGL-SDHLSTFLAGLASHNCCQFLSHLAQRNEAWVSSRQAAVVQVLRKLATRKHT
GPKVVELCHCVAETQEPELARLIAQNLPFQFSFHNFPLTRADLASLASILEQRASPIHLD
FDGCPLEPYCPEVLVGCGQVENLS-FKSRKCGDTFVEALCRSLPTMGSLQTLGLTGSKIT
ARGISYLVQALPLCSKLEEISLQDNQLKDPEVLSLAELLPCLPQLRKLDLSRNSFSVSTL
LSLVKVATTCPTVRKLQVRESDLLFLLSPLTETIEPGPS----------------VFYPY
SR----LQKCQLRVHDAEALVELFQKGPQLEEVDLSGNYLEDEGCRLMAEAASQLHIARK
LDLSDNGLSGTGMAYVLRAMGSCGMLAE-LYISLLSNTVVLTFAYESR---EQEGSWKSI
HLLGGPWR--TV------DLAPCRLTSCDLQA-KHTEKLCEALRASCYL

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1153)

NHL--GHLDLS
DNALGDEGVALLAQQLPSLGPLQSLNLSKNGLSLNAVFGLVQCMSSLSWMFHLDVSLESE
HI---LLRGAWT-GSGLAHG---------------------------SGPHFLLQE--CQ
LEPLSLTHLCDTLKACPGPLEIQLSCKTLSDD----SLETLLRCLPQLPQLSLLQLRHTV
LS---SRSPLLLANFF----NL-C--PRVQKVDLRSLYHVALYFQSSEKQEGVCFG-FHS
CNLSQEHVEPLCCALG-RC-KA------L

PF13516 // ENSGT00860000133673_1_Domain_9 (1410, 1431)

SQLDLTGNL----LGDGGLRCLLE---HLPQ
LPISGWLDLSHNSISQEGILHLLETLPSYPHVSVSFPSL---------------------
-----MQC-H----------------RG--GEGQVLTRCQLDLPQLTGLLNLVRRPAGLL
GLRLEEPWVGQVGLPALLEV-----CVQTSGCITE-LSISETQ----------QQLWIRV
EFPRQEESPEATAL---------------RLAHCDLATNHELLMRQLMETCARLQQLSLS
QVNLIDDDG----ARSWLLENLLLSPCELKSFRLTSSCVSTQNLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

YCRHLEEL
DFSNNQLCE--EGVELLMRALQGTCMLKRLHLSHFPLGESTLTLLIGGLSHMTDV--FFL
------------------------------------------------------------
-----------------

PF13516 // ENSGT00860000133673_1_Domain_14 (1878, 1892)

-RHNQIGDTGAQHLAAILPRLSELRKETSSNLSIQEG------
-------------------------------------------------RVGMSLGPLNV
YWGRVWRRGSDGC-PSHSLSGNSIGPAGGAQLAKSLTLCKCLEEIMLGHNALGDLTVLGL
AQGLPP--QLRVLC---------LPAS--CLGPEGALCLAQALEQCPQVEEVSLAENNLS
GGVPRFG----KGLPLLRQ------IDLISCEIDDQAAKHLAASLILCPALEEILLSWNL
LGDEAAAELARILPHLGQLKRVDLEKNRITTFGAQLLAQGLTQGLCVPVIRLWNNPIPAD
VAQSLQSQEPRLDFAFFDKQ--------

----------------------MDPVGLQL-GNKNLWSCLVRLLTKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSQPESQLHHGLKRP---
HQSCGSSPRRK-QCKKQQL----ELAKKYLQLLRTSAQQRYRSQIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTPEGAI---M-GDLKVEDG--ADVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYL
SPESD-HDTVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGPVLTLF
SHLCNGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-LR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPPG------------HLPTSSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYSFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARQGL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL
LCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAEALIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHITRK
LDLSDNGLSVAGVHCVLRAMSACWTLAE-LHISLQHKTVIFMFAQEPE---EQKGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLDLVRCFSTLQWLFRLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAAAEFLG--FRQRCIPRSLCLSE--CP
LEPPSLTRLCATLKDCPGPLELQLSCKFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLNHATLHFRSNEEEEGVCCGRFTG
CSLSQEHVESFCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSREDQA-GKT
L--RLSEC-SFQPEHVSRLATGLSQSLQ--LTELTLTQCCLGQKQLAILLRLVGRPAGLF
SLRVQEPWADRAGVLSLLEV-----CAQASGSVTE-ISISETQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGAHHSLLVGQLMETCARLQQLSLS
QVNLCEDDD-A--SS-LLLQSLLLSLSELKTFRLTSSCVSTEGLARLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1791)

MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLS

PF13516 // ENSGT00860000133673_1_Domain_13 (1791, 1860)

HMTCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQHLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPVSLQL-GTSHLWSWLVRLLSKDPEWLNAKVKFFLP
KMDLSSGDKAQDA---AQGVILQLGRLHTQGRATWQAFIHCVCMELDVPLDLEVPLLSTW
GHG-DGF---------------------------PSQLEPGEESQPASQLHHGLKRP---
YQSCGSSPRLK-QCKNQQL----ELARRYLQLLKTSAQQRYGGGSP------GPGQPL-A
FHQAYIPPILQWSRTTVPFHTQEGAA--------LAEDG--ADVSIRDLFNT-RADKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
VTVLLGKAGMGKTTLAHRLCQRWADGQLDRFQALFLFEFRQLNLVTCLLTLPQLLFDLYV
SPEAG-SDSVFRYLEDNADRVLLIFDGLDQALHPHCSR-------EKEGPEDPSPALALF
SGLCRGTLLPGCWVLATSRPGKLPDCLPVEA-ATVHMWGFDRPRVEEYVGRVFSDPL-WQ
EAALAELRESRPLQNMCAVPALCRVTCLCLHR-LLPGSSPGQAAA-LLPTVTQNYVQMVA
TLGPRG------------FLPPESLLDLSEVALRGLETGKILFSLG-DIHPSTMAFGAAL
GLLTSFCICTGPGHQDTGYAFTHLSLQEFFAALYLMASPKVDKTALVGHVTLNSHWVLRT
--KARPGLLD-HLPTFLAGLASCACRPFLSLVAQQDETWVSAKQAAVMQALRKLAARRLT
GPKVVALCHCVGETQEPELASLVAQSLPCHLSFHNFPLTYTDLAALTNILGHRNAPIHLD
FEGCPLEPHCPEALAGCKQVENLS-FKSRKCGDAFAEALSKSLPTMGNLKKLGLSGSKIT
ARGIGHLVPALRLCPQLEEVSFQDNQLKDWAVLNIVEVLPCLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 900)

RLQKLDLSRNNVSVSTL
LCLTKVAVACPTVRTLQVREADLIFLLSPPTETAAELQGAPDLLGNAG-QRKEAQGRSLT
LR----LQQCQLRVHDVQELIAQLQEGPRLDVVDLSGNQLDDEGCRLMAEAASQLRIARK
LDLSDNGLSVDGVHCVLSAASTCETLAE-LHISLLHKTAVLTFAPEQD---QQKGIWRRA
ALWVSLTP--LMPSEPLLHPTRIRLTHCGLQA-KHLEPLCRALRGSC

PF00560 // ENSGT00860000133673_1_Domain_6 (1128, 1159)

HLSH---L--DFS
GNALGDEGAAQLAQLLPGLGALQSLDLSENGLSLDAVLMLALCFATLQWLLHLDISSESQ
HV---VLRGDRR-GRDRLAG------GSLPQFPAGAQFLA--FGQRCVPRTFCLSQ--CQ
LEPLSLTRLCETLEKCPGPLEVKLSCEVLSDK----SLETLLHHLPRLPQLRLLQLSQTS
LS---PKSPLLLADLF----SL-C--PRVQKVDLRSLCHVTLHFKSSEEREGECCG-FTD
CGLSQEHVEPLCWLLS-KC-EE------LNQLDLSANM----LGDDGLQCLLE---CLPQ
LPISGSLDLSHNSISLESALGLVKTLPSCPRVRE-ASVNLGSEQSFWMHFSRQEEA-GKT
L--RLSQC-SFGPEHVPRLAAGLNQSLK--LTALTLSQCCLGLEQLTLLLRLLRWPVGLF
SLRVEEPWVGKAGVLTLLEV-----CTQASGNVTE-ISISETQ----------QQLCLQL
EFPHR-ENPEAVAL---------------RLAHCDLGTHHNLLVWRLMETCARLRQLSLS
QVNLCDTSS-------LLLQSLLQSLSELKTFRLTSSCVSSKGLAHVMSGLSHCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1764)

HLEEL
DLSNNRFGE--EDTKVLMGVLEGMCRLKRLNLSHLPLGGAALAALTQGLGHMTLLQSLRL
-------------------------------------------------SRNGI-GDVGC
HKLFKALRAASSFKGLGLSHSQIRDIGAQHLAAVLSELTELRKIETSMSQVVGLGYL---
------Q--------------------------ALPTCPSASRG-------PSPLWSCLP
-R---QA-----EKPALSLSGNGIGPAGGLRLAESLALCKHLEELMLGYNVLGNDTVLRL
AQRLPH--HLKVLH---------LPSS--GLSLEGALILSQALDGCPYVEEISLAENSLA
IGVPHFH----QGLPLLRQ------IDLVSCEIDNHAAKPLAASLVLCPALEEILLSWNL
LGDEAAAELAQVLPQMGRLKKMDLEKNRITACGAWLLVEGLAQGSGIQVIRLWNNPISPD
VAQHLQSQEPRLDFAFFDKQPQ------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------K
VI

PF00004 // ENSGT00860000133673_1_Domain_0 (303, 397)

FLFGKPGIGKTRLMHRICQKWAEGVLPQFLFTFLFEFRQLNLLKGKLTLQELLFDMFL
QPEDS-PHAVFQALLENAQQTLIIFDGLDEFAANMDI---------GPALTSPMSISQLF
ADLCHGNLLPGCTVLVTSRPKRLPNFLLYTVGVLAEIGGFDHEKVEEYVSHYFCQHS-FR
ERAIAHVKNNTKLLSMCFIPALCNIVCICLEYLFLK----QQMSVELPQTMTQFYIKMFL
IFLSNEE-------------TVQAILGLFDLALRGLEEKKLVFYVS-DIPEDVKEFASLH
GLLTVFEVKTSGTCPEVGYAFVHLSLQEFFAALCLMVSRRVDKNYLKKKFFLKSKWTLKN
--ETKTEF-VESFHIFLSGLSSRECRTFLMLLAEQDEAWVQEKQDVILQSLRKLAATHLS
GPKVLELCHCTFETQNLEVAQHIGSLLNFKYEFKNFRLTTLDMSALVFVINSGQDLICLD
FAGCLVDTDCLEVLAGCKNVEHLS-FRSRRCGDDFAAALSKGLQGMRNLKKLELTGGTIT
AEGMTNLVQAASQCPHLEEI----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

----------------MQPTLQNDDFNLEG-AVASIRPQLVEFLSHRLDWLLSASQHFLP
TAVLSGLAGVTDH---REKVSVLLDLLEKAGHATWKQFAQCLCMECDLPLEMEILLMSSA
GE---GNLT--------------------------QKQEAQTDASDQSSVPRGLTRR-RR
SSSP---ISDK-GAKQKRL----DSAEKYQRLLVDSICKRYGSRRAAGAAAQEPTQPL-A
FSQAFVNLVLRQSKASRLKERTDKPRED-VPSAPEPEECVDTAVRVSDLFGSVVRSGTTK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 475)

VIFLFGKPGTGKTMLMHRICQKWAEGVLHQFLFTFLFEFRQLNLLKRKLTLKELLFDLFL
QPEDS-PDAVFQHLLENAQRTLIIFDGLDEFVGNMDVSSAS---KGSLNRSSSMSISELF
AELCHGNLLPGCTVLVTSRPKRVPDFLINTVDLLAEVWGFDHEKVEEYVSHYFRHHS-FK
EQAIAHLKNNTKLLSMCQIPALCYVVCICLEYLLLK----HQTSVELPQTMTQFYIKMLL
IFINKQQGEHAGDEEAQLNSNKKAILGLCDLALKGLEAKKLVFYVG-DIPEHVKEFASLH
GLLTVFEVKTNSAHPETGYAFVHLSLQEFFAALCLMISKSVDKSHLKRKLSLKSKWTLRN
--EAKTGF-MESFHIFLSGLSSKECRTFIMLLAEQSEAWVQDKQDAILQSLKKLAATQLT
GPKVIELCHCTFETQGLEVAQHIGSLLNFKYEFKNFRLTPLDMSALVFVINSGQDVTHLD
FAGCPLDTDCLEMLASCRNVEHLS-FRSRRFGDDFAAALSKGLGEMGSLKKLEVTGGSIT
AAGLTDMVQALSHCLQLEEINLQDNRIQNPDVKTVMELFSRMEKLKKIDLSKNSLSLNAV
LLLAKEFIACQNAAELHVRKDTVII--S-FSGPSGKVPRSLDLKREQNKECVTP-TRHLR
LC----LQARCLSSQHAKEIVSILQ

PF13516 // ENSGT00860000133673_1_Domain_4 (986, 1008)

SCPHLSEVDLSDNKLGDEGCSFLLENLSWISISKQ
LNLSHNLLSVTGIYSLLKAVNTCQRVVE-VEVSLYHNTAVLRFTEDGEFASPPASREEPL
YP--TDDQWDDKENQTPVPSKKIRLTYCRFQAS-DLEKLCAVLKECGSI

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1152)

SE---LD--LS
NNYLGDEGLAQLLQFLPNLKTLRSLKLNNNHLSLSSVFCLAQSLCTLEHLETMDLSLGRM
QVV-HLTFGDRI---RLRRT------SRWRSCF------LVHPKHVTNGQCFRLRN--CT
VGPEDVTRLCQMLMQCTQLTEIDLCGNALNDQ----SIERLLSFLPHFCQLTLLSIRNNT
FS---PCCAVLFANSI----NL-C--ERIRRVEVRSSQNAFLHLRTSTQGQKTSCR-LTD
CAIGQRQIEKLCRVLE-Q-HGCL-----

PF13516 // ENSGT00860000133673_1_Domain_9 (1409, 1426)

-AELDLSRNQ----LGDEVLRFLLD---HLHR
VPVTCSLNLSHNRISQRGVLHLINTFTTSGNTTE-VQVSLCSKATLIIKMTSRDDP-RKI
L--RLTEC-SFQPEHLEKLCLVLENCTN--LTECISSNNNVTVDAAGGLLRSLSKTPGPL
KISIEEPWVCKLSVTSLLEL-----AVQAHGNITA-IMICKEK----------NLFQLGV
RLPHCLEKVGSVVS---------------RLNLNEPEIKQACFYQRVHDKCTQLQELRWS
HVELHDD-T-------EMLVSILLPLPDLKKFELTSCSFTPTGIDCLITGLQRCQAIEEL
------------------------------NLGHMKLGDAAIPKLVFGLCEM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1864)

PSLKRLIL
-------------------------------------------------NHNSI-GDDGC
SRL

ENSGT00860000133673_1_Linker_13_14 (1864, 1871)

AEALSSM

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

HCMEEINLGHNKIGDLGLINIAAVLLEMQNLKRI----------------
------------------------------------------------------------
-----------------DLSGNCPSPAGGEKLMEALA

PF13516 // ENSGT00860000133673_1_Domain_19 (2018, 2041)

NCKHLEELILSRNDFGDGTAVKL

ENSGT00860000133673_1_Linker_19_20 (2041, 2047)

ALCLPH

PF13516 // ENSGT00860000133673_1_Domain_20 (2047, 2080)

MNRLKILH---------LQHN--NIGPAGGTEL

ENSGT00860000133673_1_Linker_20_21 (2080, 2151)

ARALMACELLEEISLSENNLG
EGGIRALSEGLPRFEHLRK------IELRLCGITDDASKLLSRGFQQCPA

PF13516 // ENSGT00860000133673_1_Domain_21 (2151, 2170)

VEEIILSWNA
LGDGGAQVLASILPGMETLKMLDLEKNLIGACGATRLAEELVRCPEIQFIRLWDNPVPKG
LAESLTSQDPRLCFSFC-----------

----------------------MDTESIRL-SNENRWAWLMRMLSKKPEWLSAKLRFFLP
TMDLDCSHELSNP---EV-IHCQLNRLFAQGRATWESFIYTLCFELDVPLDMEVPLLSIW
GPR-DEF---------------------------SKQLGAGEESCPGPQLYHGVKRP---
FQSYGSSPRRK-NSKKQQL----ELAKKYLKLLKTSAQQWHGGMYP------GAWLTP-D
SPQNYIPPILQWSRATAPLDAQEGAT---L-GDPEAAYN--IDVSIQDLFSF-KAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAYQLRWRWAQGQLDRFQALFLFEFRQLNMITQLPTLPQLLFDLYL
RPESE-PDAVFQYLEENAHQVLLIFDGLDEALHA-----------DSVGTDNAGSALTLF
SELCHGNLLPGCWVMTTSRPGKLPSCVPKEA-VMVHMWGFDGLRVEKYVTHFFSDLL-SQ
ELALKEMRTNARLRGMCAIPALCTVTCFCLRR-LLPGSSLEQSAA-LLPTITQLYLQMVE
TFSPSG------------TLLDTSILGFGKVALRGLDTGKVIFSVE-DISPQLMAFGAVH
RLLTSFCIHTRPGHEEIGYAFVHLSLQEFFAALYLMASHTVNKDTLVEYVTLNSHWVLRT
--KGRLGL-SDHLPAFLAGLASHTCHTFLCQLAQQDGAWVGSRQAAVIQVLRKLASRKLT
GPKMIELYHCVAETQDLELARFTAQSLPFHLSFHNFPLTHADLAALANILEHRDDPIHLD
FDGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAEALCRSLPTMGNLNTLGLTGSRIT
AQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRSIL
LSLVKVAITCPTVRKLQVRESDLIFYLSPVTETATQQSGASDVQGKDS-LK-EGQSRSLQ
LR----LQKCQLRVRDAEALVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

QLEEVDLSGNHLEDDGCRLVAEAASQLHIAQK
LDLSDNGLSQTGVTYVLEAMSTCRTLEE-LHISLLSNTMVLTFAQEPR---EQEGSCEGR
APLISFVS--PVTSELSQRSRRIRLTHCGFLA-KHTEKLCEALRASCQTY

PF13516 // ENSGT00860000133673_1_Domain_6 (1131, 1152)

NL--DHLDLS
DNSLGDKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVLCLSSLPWVFHLDVSLESD
CI---FLRGAGT-SRDA----------QEPKFQAGVQVLE--LSQWYTSRSFCLQE--CQ
LEPTSLAFLCATLEKSPGPLEVQLSCKSLSDD----SLKILLQCLPQLPQLSLLQLRQTV
LS---SRSPFLLADIF----NL-C--PRVRKITLRSLCHAVLHFDSNEEQEGVCCG-FPE
CSLSQEHMETLCCALS-KC-NA------

PF13516 // ENSGT00860000133673_1_Domain_9 (1409, 1431)

LSQLDLTDNL----LGDSGLRCLLE---CLPQ
LPISGWLDLSCNSISQEGILYLLETLPSYPHIQE-VSVSLSSEKIFRMHFSKKEGA-GTS
L--RLCEC-SFSSEQVSRLASSLSQAQQ--LTELWLTKCLLDLPQLTVLLNLVNRPTGLL
GLRLEEPWVNSVSLPALMEV-----CAQASGSLTE-LSFSESQRLSEAPALSSGSLWLRL
EFPHQEGNSDSMAL---------------RLAHCDLGTEHNHLMRQLVETCARLQQLSLS
QVSFNDNDG----TSSKLLQNILLSSCELKSFRLTSSQVSTKTLTHLAFGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1781)

HCHHLEEL
D------------------------------LSFLPLGAS

ENSGT00860000133673_1_Linker_12_13 (1781, 1795)

SLALLIQGLSQMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1892)

LQDLCL
------------------------------------------------------------
------------------SYNQIGDVGTQCLAA---------------------------
------------------------------------------------------------
-----ILPKLPEL

PF13516 // ENSGT00860000133673_1_Domain_18 (1994, 2012)

-RKFDLSGNAIGPAGGVQLVKSLTHFEHLEEIKLGNNDLGEPTALEL
AQRLPP--QLRVLC---------LPFS--HLGPEGALSLAQALEQCPHIEEVSFAENNLA
GGVPRFS----KRLPLLRQ------IDLELCKIEDQAARHLAANLTLCPALEKLLLSWNR
LGDEVAAELAQVLPQMGQ

PF13516 // ENSGT00860000133673_1_Domain_22 (2179, 2198)

LKKVDLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPIPND
VAQSLQSQEPRLDIFIIDQQTL------

----------------------MDPISLQL-DTENL-GWLVSLLSEHPEWLSAKVKFFLP
NKDLGSGNEALEL---RQTVSLQLRELHAQGTATWQEFINCVCMELDVPLDLEVVLLSTW
GHG-EGF---------------------------PSPSEADEESQPESQLHHGLKRP---
HQSCESSPCPK-QSRKQQL----ELAKKYLQLLRTSARQRYGDKLP------GPGQPL-S
SRQAYVPPILQWGRTTAPFDTQEGVM---M-GDPKTEDG--ADMSIWDLVNT-RAEKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
VTVLLGKAGMGKTTLARRLCQGWADGHLHRFQALFFFEFRQLNLVTSFLTLPQLLFDLYL
SPEAG-RDAVFQYLEENANEVLLIFDGLEEALE-------------TVGPEDPGSALALF
ASLCRGKLLPGCWVIATSRPGKLPACLPTEA-AIVHMWGFDGPRVEEYVGRFFSDEL-LQ
KSALAELRANRHLQSMCAVPALCQVACLCLCR-LLPGSSPGQSSA-LLSTVTQNYVQMVL
ALSPRG------------YLDAESLLGLSELALLGLQTGKVIFSAG-DIPPSMMVFGIAR
GLLTSFCVYTGPGHQETVYAFTHHSLQEFFAALHLMASPKVDKDTLVRYVTLNSRWLLRT
--KSRPGLLG-HLPTFLAGLASRGCHSFLSRLMQKDEVWVGTKQAAVVQALRKLATRRLT
GPKVVELCHCVGETQEAELAGLMAQSLPDQLPFHNFPLTYVDLAALTNILRHRDAPIHLD
FEGCPPEPRCPEALAGCGKVENLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
ARGISHLVQALPSCPYLEEVRLQDNQLKDQEVLNIVEVLSCLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 900)

QLRKLDLSRNNVSVTTL
LCLTKVAVTRPSIKMLQVRKEDLVFLLSPPTERAAEPQGSPDLQGNAS-QRKEARGRSLT
LR----LQNCQLTIQDVEMLIAQLQEGPHLDEVDLSGNQLEDEGCQRMAEAAPQLHIAGK
LDLSDNGLSVAGVHRVLSAVSTCRTLAD-LHISLLHKTVVLTFVPKME---EQEGTQGRV
PVLDSLVP--QMPSELPLHSSRIRLTYCGLQA-QHLEQLCTALRGSCSPSH---L--DLS
GNALGDEGATQLAQQLPGLGTLQSLNLSENGFSLDTAFSLAQCFSTVQWLFHVNVSFESQ
VV---IMRGDRR-TRDLSAG------GSLPEFPARAQFLG--FGRRCIPRSFCLTE--CP
LEPLSVTRLCETLEKCPGPLEVKLSCGVLSDQ----SLDALLGHLPQLPKLSLLQLNQTE
LS---PGSLFLLANFF----SL-C--PRVQKVDVRSLYHVTLHFRSNEEQKGGRCGRFTG
CGLSQEHVEPLCKLLR-KC-ED------LSQLDLSANQ----LGDDGLRCLLE---CLPR
VPISGSLXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXLGSQKSFWIHFSQQEEA-GKM
L--XXXXX-XXGPEHMPRLTSGRQ---Q--LTELTLTRCCLGLQDLTVL-SLVTRPEGLL
SLXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXX----------XXXXXXX
XXXXX-XXXXXXXX---------------XLSHCDLETHHSLLVRQLMETCTRLQQLS-S
QVNLCDVS--------LLLQSLLLALSELKKFRLASCRVSSQGLAHLAFGLSHCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1775)

HLEEL
DLSNNQLGK--EDTKVLMGALEGKCWLKRLDLSNFLLGGPTLAVLTXXXXXXXXXXX---
----------------------------------------------XXLSRNDT-CDVGC
YHLSKALRAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

SLEELGLSYNQIGDTGAQHLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANNIGLAGGVQLAESLTLCKHLEELKLGCNAVGNPTALGL
AQGLPQ--HLRVLH---------LPSS--RLGPEGALSLGQALDGCPHLEEISLAENSLA
GGVPHFR----QGLPLLRH------IDLVSCDIDNQTAKPLTANFVLCPALEEILLSWNL
LGDEAAAELARVLPRMGRLKRV----------GAWLLAERLAQGSGIQVIRLWNNPIPPD
SAQRLQSQEPRLDFAFFHNQPQASQGT-

----------------------MDHVSFQL-GTTNLWSWLVRLLSKDPEWLNAKVKFFLP
KMDLSSGDEAQDT---TQRVMLQLRRLHTQGRATWQAFIHCVCMELDVPLDLEVPLLSTW
GHG-DGF---------------------------PSQLGAGEESQPASQLHHGLKRP---
HQSCGSSPRLK-QCKNHQL----ELARRYLKLLRTSAQQRYS-RIP------GPGQPL-A
FHQAYIPPILQWSRTTAPFSAQDGAV---V-GDPKAEDD--TDVSIRDLFST-RADKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQRWAAGQLDRFQALFLFEFRQLNLITSSVTLPQLLFDLYL
SPEAG-PDSVFQYLEEHAGGVLLIFDGLDQALHSHSST-------EPEGPEAPSPALALF
SGLCRGTILPGCWVLATSRPGKLPDCLPTEA-ATVHMWGFDRPRVEEYVGRFFSDQE-WQ
EAALAELRENRHLQSMCAVPALCQVTCLCLHH-LLPGNSPGQSAA-LLPTVTQNYVQMVS
TLSPRG------------YLPPESLLGLSEMALRGLETGKVIFSVG-DISPPMVAFGAAL
GLLTSFCICTGPGHQGIGYAFTHLSLQEFFAALYLMASPKVDKNVLARHVTLNSRWVLRT
--KARLGLLD-HLPTFLAGLASCACRPFLSHVAQQDEMWVSDKQAAVMLALRKLAIRRLT
GPKVVALCHCVGETQEPELASLMAQSLPSHLSFHNFPLTYTDLSALTNILRHRNASIHLD
FEGCPLEPHCPEALAGCKQIENLS-FKSRKCGDAFAEALSKSLPTMESLKKLGLAGCKIT
ARGISHLMQALRLCPQLEEISFQDNQLKDRAVLNIVEVLPSLPRLQKLDLSRSNVSVSTL
LCLTKVAVTCPTVKMLQVRETDLIFLLSPPTETAAELGAAPDLQGNAI-QRKEAQSRSLA
LR----LLQCQLGIHDVQELIAQLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1009)

PRLEEVNLSGNQLDDEGCRLMAEAASQLHITRN
LDLSNNGLSVDRVHCMLSAVNTCQNLAE-LHISLLHKTVVFTFAPEQE---EQEGIWKRT
ALRDSLTH--QVPFELPLRSTRIRLTHCGLQA-KHLEQLCRALGGSCHH

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1154)

SH---L--DLS
GNALGDEGVAQLAQLLPGLGALQSLNLSENGLSLDTVFILIQCFSTLQWLLHLDIGFESQ
HV---VLRGDRR-GRDRLAG------GCPPEFLAGVPFLA--FDQCCVPESFCLRQ--CQ
LEPLNLTRLCETLEKCPGPLEVELSFEVLSDQ----SLETLLQHLPRLPQLSLLQLSQTR
LS---PKSLLLLADLF----SL-C--PRVQKVDIRSLYHMTLHFRSGEEHEGECCGRFTG
CGLSQEHVEPLCWLLS-KC-ED-----

PF13516 // ENSGT00860000133673_1_Domain_9 (1408, 1431)

-LNQLDLSANM----LGDDGLRCLLE---CLPQ
LPISGSLDLSHNSISLESALGLVKTLPSCPHIRE-ASVNLGSEQSFWIYFSRKEEA-GKT
L--RLSQC-NLMPEHVPRLATHLNQALK--LTALTLTQCGLGLEQLIVLLSLLRCPVDLF
TLRVEEPWVGKAGVLALLRV-----CTQTSGNITE-ISISETQ----------QQLCLQL
EFPPQ-ENPEAVTL---------------RLAHCDLETHHSLLAGQLMETCARLQQLSLS
QVNLCDSSS-------LLLKNLLVSLSELKTFRLTSSCMSSKGLAHLTFGLRN

PF13516 // ENSGT00860000133673_1_Domain_12 (1734, 1755)

CHHLEEL
DLSNNQFGE--EDT

ENSGT00860000133673_1_Linker_12_13 (1755, 1795)

EVLMTVLEGKCWLKKLDLSHLPLGSSTLAMFTQGLSHMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1864)

LQSLRL
-------------------------------------------------SRNGI-CDVGC
HQL

ENSGT00860000133673_1_Linker_13_14 (1864, 1872)

SEALRAAM

PF13516 // ENSGT00860000133673_1_Domain_14 (1872, 1892)

SLKELGLSHNQIRDTGAQHLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSGNGIGPAGGTRLAESLTL

PF13516 // ENSGT00860000133673_1_Domain_19 (2019, 2042)

CRHLEELMLGYNVLGDTTALGL
AQGLPC--CLRVLH---------LPSS--RLGPKGALSLSQALDGCPHVEEISLAENSLA
RGVLHFC----QGLPLLRQ------IDLVSCEIDNHTAKPLAASLVLCPALEEILLSWNL
LGDEAAAELARVLPQMGRLKRMDLEKNRITACGAWLLAEGLAQGSGIQVIRLWNNPISPT
MVQHLQSQEPRLDFAFFDK---------

----------------------MDPVGLQL-GNKNLWSCLVRLLTKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTF
GYD-DGF---------------------------TSQLGAEGKSQPESQLHHGLKRP---
HQSCGSSPRRK-QCKKQQL----ELAKKYLQLLRTSAQQRYRSQIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTPEGAI---M-GDVKVEDG--ADVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYL
SPESD-HDTVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGPVLTLF
SHLCNGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-SR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPNMTQLYMQMVL
ALSPPG------------HLPTSSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARLGL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL
LCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAEALIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSNNGLSVAGVHCVLRAVSACWTLAE-LHISLQHKTVIFMFAQEPE---EQKGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQE-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQ
HI---LLRGDKT-SRDMWAT------GSLPDFPAAAKFLG--FRQRCIPRSLCLSE--CP
LEPPSLTRLCATLKDCPGPLELQLSCEFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTG
CSLSQEHVESLCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSISQESALYLLETLPSCPRVRE-ASVNLGSEQSFRIHFSREDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSKSLQ--LTELTLTQCCLGQKQLAILLSLVGRPAGLF
SLRVQEPWADRARVLSLLEV-----CAQASGSVTE-ISISETQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGAHHSLLVGQLMETCARLQQLSLS
QVNLCEDDD-A--SS-LLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1793)

MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1860)

TCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_15 (1860, 1871)

C
CHLSEALRAA

PF12799 // ENSGT00860000133673_1_Domain_15 (1871, 2005)

TSLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPHLEEISLAENNLA
GGVLRFC----MELPLLRQ------IDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQHLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPVGLQL-GNKNLWSCLVRLLTKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSQPESQLHHGLKRP---
HQSCGSSPRRK-QCKKQQL----ELAKKYLQLLRTSAQQRYRSQIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTPEGAV---M-GDLKVEDG--ADVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYL
SPESD-HDTVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGPVLTLF
SHLCNGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-SR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPPG------------HLPTSSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVPTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARLGL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FRSRKCGDTFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL
LCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAEALIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSVAGVHCVLRAVSACWTLAE-LHISLQHKTVIFMFAQEPE---EQKGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVQCFSTLQWLFRLDISFESQ
HI---LLRGDKT-SRDMWAT------GSLPDFPAAAEFLG--FRQRCIPRSLCLSE--CP
LEPPSLTRLCATLKDCPGPLELQLSCEFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNQEEEGMCCGRFTG
CSLSQEHVESFCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSREDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLGQKQLAILLSLVGRPAGLF
SLRVQEPWADRAGVLSLLEV-----CAQASGSVTE-ISISETQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGAHHSLLVGQLMETCARLQQLSLS
QVNLCEDDD-A--SS-LLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1791)

MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLS

PF13516 // ENSGT00860000133673_1_Domain_13 (1791, 1860)

HMTCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MVQHLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPVGLQL-GNKNLWSCLVRLLTKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTF
GCD-DAF---------------------------TSQLGAEGKSQPESQLHHGEDWS---
WGQRAGWSSPH-AMSLPLA----ELAKKYLQLLRTSAQQRYRSQIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTPEGAI---M-GDLKVEDG--ADVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYL
SPESD-HDTVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGPVLTLF
SHLCNGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-SR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPPG------------HLPTSSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARLGL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDTFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSNNSICVSTL
LCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAEALIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSVAGVHCVLRAVSACWTLAE-LHISLQHKTVIFMFAQEPE---EQKGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGFSLDAVLGLVQCFSTLQWLFRLDISFESQ
HI---LLRGDKT-SRDMWAT------GSLPDFPAAAEFLG--FRQRCIPGA--SGT--CP
LEPPSLTRLCATLKDCPGPLELQLSCEFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNQEEEGVCCGRFTG
CSLSQEHIESFCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSREDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLGQKQLAILLSLVGRPAGLF
SLRVQEPWADRAGVLSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGAHHSLLVGQLMETCARLQQLRSA
PGNSVWGPE-F--SAAKTQGGSCLTCCPLTPTRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1755)

HCHHLEEL
DLSNNQFDE--EGT

ENSGT00860000133673_1_Linker_12_13 (1755, 1791)

KVLMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLS

PF13516 // ENSGT00860000133673_1_Domain_13 (1791, 1860)

HMTCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MVQHLKSQEPRLDFAFFDNQPQAPWGT-

-----------------------DELELQA-AVARARPRLARLLARCPRWLLATARRLLP
EPALSGLGGIADP---AEKTSALLRLLEEAAPAAWKHFAQAVCMEYDLPLDLEVLLMSSA
GE---GYFS--------------------------QTEEAGTDTRVQSSVPK---GSARC
PSSS---GSDK-EAKQRRL----DSSAKYRHLLINSIRQRYGSRREAGAEAQEQTQPL-P
FNQTFVNVVIHRSKAPRSRERAEKPREE-LAGAAEPEECADTAMKVSDLFCSEAPSHTTK
VI

PF00004 // ENSGT00860000133673_1_Domain_0 (303, 446)

FLFGKPGTGKTRLMHRICQKWAEGVLPHFLFTFLFEFRQLNLLKRKLTLKELLFDMFL
QPEDS-PDAVFQGLLENAQQILIIFDGLDEFAANMDVSWSS---RRDPGLSSPVPISQLF
ADLCQGKLLPGCTVLVTSRPKRLPDFLLHTVSVLAEIWGFDHEKVEEYVSHYFHQHS-FR
ERAIAQVKNSTKLLSMCFIPALCNIVCICLEYLLLK----HQMSVELPQTMTQFYIKMFL
IFLNKQQGDRAGDEETQLNCNKKAILGLFDLALRGLEEKKLVFYVG-DIPEDVKEFASLH
GLLTVFEVKTSGTCPEVGYAFVHLSLQEFFAALCLMVSRRVDKNYLKKKFFLKSKWNSKN
--ETKTEF-MESFHIFLSGLSSRECRTFLMLLAEQDEAWVQEKQDVILQSLKKLAATHLS
GPKVLELCHCTFETQNLEVAQHIGSLLNFKYEFKNFRLTTLDMSALVFVINSSQDLICLD
FAGCLVDTDCLEVLAGCKNVEHLS-FRSRRCGNDFAAALSKAMQGMGSLKKLELTGGSIT
AEGMTDLVQAASQCLQLEEINLQGNRIRDPDVKRVMDLFSKMEKLKKVDLSNNHLYLNAV
LSLAKEGIVCQNVTELCARYQHIINLLSVSKGSPGEVQRSLDLKLEENKDNIIP-TRHVN
LC----LQDHRLSSQHSKMIVAILQSCPCLSEVDLSGNKLGDEGCSYLLESLPWISISKQ
LNLSQNCLSVTSICSLLKSVETCQRVME-VQVSLCHDTAVLRFREDREFAALPP-REEPV
LF--TDDQQHGEENQTPTSSQKIRLTDCNFQAS-DLKNLCAVLKECGHISE---LDPSLS
HNYLGDEGLLQLFQCLPKLKMLRSLKFNGNQISLNSVFFLAQSLATLEHIKTVSLRYDQE
YFLTGGEVTVGS---VWCV-------GQSH------------SSSCVSSESRNLRD--CR
VALEDVTRLCQTLAQCP

PF00560 // ENSGT00860000133673_1_Domain_8 (1278, 1311)

QLTEIDLSGNSLSDQ----SIERLLSFLPSLCNLTLLSIRRNP
LS---PHCAVVLLNSI----SL-C--ERIRVVEVRSSENVFLYLGASPQSQKTSCR-LTG
CAIGPGQVEQLCSILE-Q-HGGL------AEVDLSRNE----LGDEGLRRLLD---HLHR
VPGTCSLNLSHNGISQDGVLHLINAFVTSGNTTE-VQVSLCSKATLIIKLTSGNDP-RKI
L--RLAEC-NFQPEHLDKLFLLLEKCTA--LTEYTSSNNNMTVQAAERLLHSLRKDLGLL
KISIEEPWVCKEGARNLLQL-----AVQASGDISG-ITICKDK----------TLFQLVI
RFPHCLEKTGSVIS---------------RLSLYKPEIKH-SFCQRLCEKCAQLQELRWS
HVELHEDEA-------EILARILLPLPELKMFGLTSSSVAATGIEYLISGLQNCQAIEEL
KLSRGCQVF--LEALGCPWV------IPSFSLGYMKLSSAAIPGLVLGLCEMPSLKRLVL
-------------------------------------------------NHNNI-GNDGC
SKLAEALRGMHNMEEINLSHNNIGDPGLISLAAVLLEMQNLKKL----------------
------------------------------------------------------------
-----------------DLSGNCPSPAGGERLMAALAHCRHIKELLLSRNGFGDRTAVTL
ALCLPHMTSLKILH---------FQNN--EIGQAGGLELARALVVCELLEEISLSENALG
EQSVRALSQGLPCFQHLRR------MDLKFCGITDDASKSLSLAFRQCPSLEEIILSWNA
LEDGGAQELAIALPKMEKLKVLDLEKNRIGASGATKLMEELAKCPGIQFIRLWDNPVPKG
LAESLTSQDPRLRFSFN-----------

----------------------MDPVDFQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGGEGKSLPESQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKSGMGKTTLAHRLCQKWAEGHLDYFQALFLFEFRQLNLITRFLTPSQLLFDLYL
SPELD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPTGPDGPGSVLTLF
SRLCHGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSTQP-SR
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGELALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLNL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCINTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSICVSTL
LCLARVAVTCPTIRMLQARKADLIFLLSPPTETTAELQRAPDLQKSDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LRISLQHKTVVFMFAQEPQ---EQEGPQERA
AFLDSLTL--QMHSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLSHLCATLKECPGPLELQLSCEFLSDQ----SLKTLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-RKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
ILRVQEQWTDRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRREENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-A--SS-LLLQNLLLSLSELKTFRLTSSCVNTRGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGIKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLVLCRHLQELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAIGAWLLAGGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPIDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPESRLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-T
LHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-ATVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNIVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLRHKTVVFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLNQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLNQEHVESLCRLLG-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

----------------------MDAESIRL-NNENLWAWLVRLLSKNPEWLSAKLRSFLP
TMDLDCSYEPSNP---EV-IHRQLNRLFAQGMATWKSFINDLCFELDVPLDMEIPLVSIW
GPR-DEF---------------------------SKQLGAGEESCPGPQLYHGAKRP---
FQSYGSSPRRK-NSKKQQL----ELAKKYLKLLKTSAQQWHGGVCP------GAWLTP-H
SPQTYIPPVLQWSRATAPLDAQEGAT---L-GDPEAADN--IDVSIQDLFSF-KAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQALFLFEFRQLNMITQLPTLPQLLFDLYL
MPESE-PDAVFQYLKENAQEVLLIFDGLDEALHA-----------DSVGTDNAGSALTLF
SELCHGNLLPGCWVMTTSRPGKLPSCVPTEA-ATVHMWGFDGLRVEKYVTCFFSDLL-SQ
ELALKEMRTNARLRGMCAIPALCTVTCFCLRR-LLPGSSPGQSAA-LLPTITQLYLQMVE
TFSPSE------------TLLDTSILGFGKVALRGLDTGKVVFSVE-DISPQLMSFGAVH
SLLTSFCIHTRPGHEEIGYAFVHLSLQEFFAALYLMASHTVDKDTLVEYVTLNSHWVLRT
--KGRLGL-SDHLPAFLAGLASHTCHMFLCQLAQQDRAWVGSRQAAVIQVLRKLASRKLT
GPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLD
FDGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRIT
AQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRSIL
LSLVKVAITCPTVRKLQVRELDLIFYLSPVTETATQQSGASDVQGKDS-LK-EGQSRSLQ
LR----LQKCQLRIRDAEALVELFQK

PF13516 // ENSGT00860000133673_1_Domain_4 (987, 1006)

SPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQK
LDLSDNGLSQTGVTYVLKAMSTCGTLED-LHISLLNNTVVLTFAQEPR---EQEGSCKGR
APLISFVS--PVTSELSQRSRRIRLTHCGFLA-KHTETLCEALRASCQT

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1152)

HNL--DHLDLS
DNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDVSLESD
CI---FLRGAGT-SRDA----------LEPKFQTGVQVLE--LSQRYTSRSFCLQE--CQ
LEPTSLTFLCATLEKSPGPLEVQLSCKSLSDD----SLKILLQCLPQLPQLSLLQLRHTV
LS---SRSPFLLADIF----NL-C--PRVRKVTLRSLCHAVLHFDSNEEQEGVCCG-FPG
CSLSQEHMETLCCALS-KC-NA------LSQLDLTDNL----LGDIGLRCLLE---CLPQ
LPISGWLDLSHNNISQEGILYLLETLPSYPNIQE-VSVSLSSEQIFRMCFSKKEGA-GTS
L--RLCEC-SFSPEQVSKLASSLSQAQQ--LTELWLTKCHLDLPQLTMLLNLVNRPTGLL
GLRLEEPWVDSVSLPALMEV-----CAQASGCLTE-LSISEIQ----------RKLWLQL
EFPHQEGNSDSMAL---------------RLAHCDLETEHSHLMIQLVETYARLQQLSLS
QVSFNDNDG----TSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHLEEL
DFSNNSLRE--EDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1892)

LQDLCL
------------------------------------------------------------
------------------SHNQIGDVGTQCL

ENSGT00860000133673_1_Linker_13_16 (1892, 1901)

AAILPKLPE

PF13516 // ENSGT00860000133673_1_Domain_16 (1901, 1922)

LRKFDLSHNQIGD--VGTQC
L

ENSGT00860000133673_1_Linker_16_17 (1922, 1961)

AAIL--PKLPELRKFNLSHNQIGHVGTQCLAAILPKLPE

PF13516 // ENSGT00860000133673_1_Domain_17 (1961, 1980)

LRKFDLSRNQIGDVGTQCL

ENSGT00860000133673_1_Linker_17_18 (1980, 1994)

A
A----ILPKLPEL

PF13516 // ENSGT00860000133673_1_Domain_18 (1994, 2012)

-RKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALEL
AQRLPP--QLRVLC---------LPSS--HLGPEGALGLAQALEQCPHIEEVSLAENNLA
GGVPRFS----KRLPLLRQ------IDLEFCKIEDQAARHLAANLTLFPALEKLLLSGNL
LGDEVAAELAQVLPQMGQ

PF13516 // ENSGT00860000133673_1_Domain_22 (2179, 2198)

LKKVNLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPILND
VAQSLQSQEPRLDFSITDQQTL------

----------------------MDSFSHQP-DSRSLWSWLVSLLSKHQEWLSAKMQFFLP
SVEPNSSDEALDV---EQRVTQQLNKLHAQGPATWQSLVHSMCMELEVPLELEVLLLSTS
GCD-KDG---------------------------KIL------PSFFSSLSPGLKHP---
PQSCESSPCPK-YCRKQQL----ELAHKYLELLKAFVHQHHDSKCW------GPEETL-T
THQYYIPTILQWSRATAPLDTQERTI---K-RDFKTEDG--GDVDFQDLFNF-RTHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 474)

R
VTVLLGKAGLGKTTLVRRLRQKWADGQLGHFQALFLFEFRQLNLIKGFLTLRQLLFDLYL
SPESG-SDAVFQYLQEKANRVLLIFDGLDETLS----------------PDGAASVHTLF
SNLCRGTLLPGCWVITTSRPGKLPTCLPREV-AMVHMWGFDGQRVEEYMSHFFSGQP-SK
EMVLEELRANGRLRSMCAVPTLCRITCLCLHH-LLPRTPTDQSAA-LLPTVTQLYMQMLL
SLSPCE------------DLPAGSLLGLGEVALGGLDSGKVIFYSG-DIPPALLAFGATH
SLLTSFCTCTSPGHWETGYAFAHLSLQEFFAALYLMASPLVDRDTLTGHVTLNSHWVLRT
--KGRVGL-SDKLPTFLAGLAAHTCGPFLSHLAKRNEAWVCCRQAAVVQVLRKLATQKLT
GPKLVELCHCVAETQEAELATLAAQGFPYHLPFHNFPLNFADLTALTGILGHRADPLHLE
FEGCLLEPRCPEALIGCGGIESLS-FKSRKCGDAFAEALSRSLPTMKSLQKLRLVGSKVT
ARGISYLVQALPLCPQLEEVSLQDNQLKDPEVLDIVKALPCLPRLRKLDLSRNSFSVSTL
LHLVKVAVTCPTVRILQVRESDLVFLLSPPMETTADPSA-----------------PHHH
PR----LQKCRLKVCDVKVLIDMLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1009)

PHLEEVDLSENHLEDEGCRLLAEAVPQLHITKK
LDLSDNGLSMVGVAYVLRAVDMCWSLAE-LHISLLHKTVVLMFAQEAG---EQDGSWERS
GLTDGITS--AWVGIAGCGLPFRRLTHCGFQA-KHVKALYKALGGSWKGCCLWDGHLTLG
QGA--------LSHGLPVLMSPVTSSLSKNGSSLDAVLSLAQCMASLSWVFHLDIRRF--
CV----------------------------------------------------------
-------------------LFHRLSCEALSDE----SLEILLRCFPQLPQLSLLQLSQTP
LS---PRSPWLLAGAL----PL-C--PRAHAIGCRSLNQATLHFRLREEPEGVYCG-FPD
CGLGPEHVEQLCWSLG-QC-ET------LSHLDLDANL----MGNEGLSSLLE---HLQQ
TPLSGW

PF13516 // ENSGT00860000133673_1_Domain_10 (1447, 1462)

LDLSHNGISQEGALSLVETLPSNPRIREVRPAV----------PTQASPS-ASS
L--RLSHC-HLRPEHVPRLAAGLSHALQ--PMELTLTECSLDLTQLMVLLSWVKPPAGVL
GIRVEEPWVGRAGVLALLEV-----CAQVSGCLFL-LTPKGSI-------------AQQL
LSPH------QGSL---------------VLAGHGPGTPYSCLVIQLMETCGRLQQLSLS
QVNLCNEGI----ISSQLLPQILPDLMPFGPPRLTSSCASTESLTHLASGLSHCGHMEEL
DFSSSQLGV--EGTRMLVAALEGMRGLKRLQWFFLSC------------------L

PF13516 // ENSGT00860000133673_1_Domain_13 (1797, 1892)

SLSL
------------------------------------------------------------
------------------SQNQIGDVGAQHIAATLPELPELRKIDLVEPGPG----GRGS
LRLWAPKPTVARSLCFSVLADGK-------------------------VRVAGVSWVSER
VLGRGRGTGSDAVPISHSLSRNGISPAAGAQLAESLMLCQHLEVLMLGYNTLGDLTALQL
AQGLPQ--YLRVLH---------LPCS--HLGPEGALSLGRALDGHPHVEEINLAENSLA
NGVPHFC----KGLPQLRR------ISLLFCKIDDQTAKHLATSFMLCPALEEILLSWNL
LGDEAAAELAQVLPRMGQLKKVDLEKNQITARGAWLLLQGLAQEAGFPIICLWNNPIAPD
MAQRLQSQEPRLNFAFFDQQP-------

----------------------MDS------ESLQLWAWLVSLLSKNSEWLSAKVRFYLP
TMDLDCSNTAPET---EV-IHHRLRRLYTQGLATWQSFIYSLCMELDVPLELEVPLLSIW
GQK-DEF---------------------------SKQIGDGEDSHPGPLQHHGIKRP---
SQSCGSSPRRK-HCRKQQL----ELAKKYLKLLKTSARQYHGGECP------GAGHTQ-A
SPQAYIPPILQWSRATAPLDAQEGAT---I-GDPDATDD--IDVSIQDLFNV-KAPKGL

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCWRWADGQLDHFQALFLFEFRRLNMVTHMLTLPQLLFDLYL
SPESD-PDAVFQYLEENAHQVLLIFDGLDEALRA-----------SSEGADNAGSALNLF
SDLCRGTLLPGCWVMATSRPGKLPACVPTEA-AMVYMWGFDGLRVEKYISHFFSDLL-SQ
ELALAEMRTNDRLRGMCGVPALCHVACFCLGH-LLPRSPPGQSTA-LLPTVTQLYLQMVE
TFSHNG------------TLPATSLLGLGKVAFVGLNTGKVIFSVE-DIPPPLMAFGAVH
SLLTSFCIRTSPEQQEIGYAFTHLSLQEFFAALHLMASDTIDKDTLTYYVTLNSHWVLRT
--KSRLGL-SDHLPTFLAGLASHTCHAFLCRLAQRDEAWVGSRQAAVVQVLRKLANRRLT
GPKMIELYHCVAETQEPELARCTAQSLPFRLSFHNFPLTHEDLAVLANVLEHRAAPIHLD
FDGCPLEPRCPEALIGCGQVENLS-FKSRKCGDAFAEALGRSLPTMGSLKMLGLTGSKIT
ARGISHLVQALPLCSQLEELSLHDNQLKDPEVLSLVELLPCLPKLQKLDLSRNNFSVSTL
LSSVKVAITCPTVRKLQVRESDFVFLLSPITETAVQQSEAPNLQDKDS-PKKEGQSRSLE
LR----LRKCQLRVHDAEALVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

RLEEVDLSGNRLEDEGCRLVAEAASQLQIAQK
LDLSDNGLSKTGVTYVVRAVSTCGTLQE-LHISLQSNTVVLTFAQEPR---KQERSRRSA
VPLTSFAS--PVASETSQSSRRIRLTHCGFLA-KHTERLCGALRANFQL

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1153)

HHL--DHLDLS
DNSLGDKGVALLAQLLPGLGPLQSLNLSRNGVSLDAVFGLIECMPSVQWVFHLDVSLESD
HI---LLQGAGT-GRDAPAG------RCEPEFPAGAPLLA--FGPHYTSRSFRLRG--CQ
LEPLSITCLCATLEKCPGPLEVHLSCKTLSDE----SLKTLLQHLPQLPQLRLLQLSHTV
LS---SRSPFLLADVF----NL-C--PGVQKVNLRSLCHAVLHFGSKEEQEGVCFG-FPG
CSLSGEHMEPLCGVLS-GC-KA------LSQLDLTNNL----LDDNGLRCLLE---CLPR
LPICGW

PF13516 // ENSGT00860000133673_1_Domain_10 (1447, 1462)

LDLSHNRISQEGVLCLLEALPSCPRVCE-ISVSLDSEQNFRIRLSKEEEA-GTK
L--RMCEC-SFGPEHVSRMASSLSQARQ--LTELTLTRCHLDLPQLTNLLNLVTRPAGLL
GLRLEEPWVGHISLLTVMDV-----CAQASGCLTE-LSLSETQ----------RQLWLRL
EFRHQEDSSEFMAS---------------RLAHCDPGADHSLPKRQLKETCARLQQLSLS
QVNFKDDDD----ARSGLLQNLLLSSSELKSFRMTSSCVSTESLTHLASGLRHCHHLEEL
DFSNNHLYE--ENIEPLMAALQGTCKLKRLHLSHSPLEASSLALLIQGLSHM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1887)

TLLQHLCL
------------------------------------------------------------
------------------RHNQIGDA

ENSGT00860000133673_1_Linker_13_15 (1887, 1901)

GSQNLAAILPGLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKL----------------
------------------------------------------------------------
-----------------DLSGNSIGPAGGEPLAKSLIHCKCLEEIILGNNALGDPTVLGL
AQRLPP--QLRVLR---------LPSS--HLGPEGALCLARALERCPRLEEFSLAENNLA
GSVPHFC----KSLPLLRQ------IDLISCKIDDQAAKHLATSLMLCPALEEILLSWNL
LGDEVAAELAQVLPQMGQLKRVDLEKNRITACGAQLLAQGLVQGSCVPVIRLWNNPIPAH
VAQSLQRQDPRLDFAFFDQQPQTL----

----------------------MDSESFQL-GTENLWAWLVRLLSKNSEWLNGKIRFYLP
TMDLDCSNTAPEP---EV-IHHQIRRLYTQDQATWQSFINSLCMELDVPLELEVPLLSIW
GQK-DEF---------------------------SRQIGAGEDGHPGPLPHHGVKRP---
SQSCGSSPRRK-HCRKQQL----ELAKKYLKLLKTSARRYHGGECP------GAGHTH-A
SPQAYIPPILQWSRATAPLDAQEGAT---I-GDPDTADD--IDVSIQDLFNF-KAPKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCWRWADGQLDRFQALFLFEFRRLNMITHLLTLPQLLFDLYL
RPESD-PDAVFQYLEENAHQVLLIFDGLDEALHA-----------DSVGADNAGSALNLF
SDLCRGTLLPGCWVMATSRPGKLPACVPTEA-AMVYMWGFDGLRVEKYISHFFSDLL-SQ
ELALAELRTNERLWGMCAVPALCQVACFCLRH-LLPRSPPGQCAA-LLPTVTQLYLQMVE
TFSHNG------------ILPATSLLSLGKVAFGGLDTGKVIFSME-DIPPPLMAFGAVH
GLLTSFCIRTSPEHQETGYAFAHLSLQEFFAALYLMASDTIDKDTVTYYVTLNSHWVLRT
--KSRLGL-SDHLPTFLAGLASHTCHAFLCHLTQQDEAWVGSRQAAVVQVLRKLASRKLT
GPKMIELYHCVAETQELELARFIAQSLPFRLSFHNFPLTHADLAALANVLEHRAAPIHLD
FDGCPLEPRCPEALVGCGQVENLS-FKSRKCGDAFAEALGRSLPTMGSLKMLGLTGSKIT
ARGISHLVQALPLCSQLEELSLHDNQLKDPEVLSLVKLLPCLSKLQKLDLSRNSFSVSTL
LSSVKVAITCSAVRKLQVRESDFVFLLSPITETTVQQSEALNLQDEDS-LKKEGQSRSLE
LR----LQKCHLRVHDAEALVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

RLEEVDLSGNHLDDEGCRLVAEAASQLQIAQK
LDLSDNGLSKTGVTYVLRAVNTCGTLEE-LHISLQNNIVVLTFAQEPR---KQERNCKGG
VPLTSFAS--PVASETSRSSRSIRLTHCGFLA-KHTERLCGALRVNCQ

PF13516 // ENSGT00860000133673_1_Domain_6 (1129, 1153)

LHHL--NHLDLS
DNSLGDEGVALLAQLLPGLGPLQSLNLSRNGVSLDAVFDLTTCMSSVQWVFHLDVSLESE
HI---LLQGAGT-GRDAPAG------RCGPEFPAGAPLLA--SSPLYTSRSFRLQG--CQ
MEPLSLARLCATLEKCPGPLEVHLSCKTLSDE----SLKTLLQCLPQLPQLRLLQLSHTV
LS---SRSPFLLADVF----NL-C--PGVQKVNLRSLCHAVLHFDSKKEKEGVCFG-FPG
CSLSQEHMEPLCCALS-RC

PF13516 // ENSGT00860000133673_1_Domain_9 (1400, 1431)

-TV------LSQLDLTDNL----LDDSGLRCLLE---CLPQ
LPICGWLDLSHNSISQEGVLCILETLPSCPRVCE-VSVSLGSEQNFRICLSREKEV-GTK
L--RMCEC-NLGPEYVSRLASSLSQAQQ--LTELTLTRCHLDLPQLTNLLNLVNRPAGLL
GLRLEEPWVGHVGLLAVMEV-----CAQASGCLTE-LSLSETQ----------KQLWLRL
EFPHQEDSSEFMAN---------------RLAHCDPGTGHSLLMRQLMETCSRLQQLSLS
QVNFSDEDN----KRSRLLQNLLMSSSELKSFRLTSSCVSTESLAHLASGLR

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1749)

HCHHLEEL
DFSNNHLC

ENSGT00860000133673_1_Linker_12_13 (1749, 1795)

K--ENIELLMGALQGTCKLKRLHLSHFPLEASSLALLVQGLSCMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1891)

LQHLCL
------------------------------------------------------------
------------------RHNQIGDVGTQN

ENSGT00860000133673_1_Linker_13_15 (1891, 1901)

LAAILPRLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKL----------------
------------------------------------------------------------
-----------------DLSGNSIGPAGGVPLAKSLTHCRCLEEIILGNNALGDPTALGL
AQRLPP--QLRVLC---------LPSS--HLGPEGALCLAQALEQCPCIEEFSLAENNLA
GNVPHFC----KSLPLLRH------IDLISCKIDDQAAKHLATSLMLCPALEEISLSWNL
LGDEVAAELAQVLPQMEQLKRVDLEKNRITACGAQLLAQGLVQGSCVPVIRLWNNPIPAD
VAQSLQRQEPRLDFAFFDQQPQTL----

----------------------MDPIGIQL-DTWNQWGCLVSLLSKNPDWLSAKMKFFLP
NMDLGSRNEILDP---EQRIISQVRLLHTQGLATWQSFIHCVCMELEVPLDLEVPLLSTW
GSE-DGF---------------------------LSQQGADEESQPESRLHPGVKRP---
HQSCGSSPRRK-QCKKQQL----ELAKRYLQLLRTTTQQRYGDRVP------GSGQPL-A
SNQAYIPPILQWTRATMPLDTQKSAI---L-GDIKVEDS--TDVSIWDLFSP-RARKGPK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 475)

VTVVLGKAGMGKTMLAHRLCQKWADGQLDRFQALFLFEFRQLNLITSVLTLPQLLFDLYL
SPEFG-PDAVFQYLKENADKVLLIFDGLDEALHPWSSK-------ETRGPGGRGPAFALF
SDLCCGTLLPGCWVMATSRPGKLPACLPAEA-AMVQMWGFDRQRVQEYVSHFFSAQP-SQ
EEVLAELQANGRLWNMCAVPALCQIACLCLHH-LFPGSAPGQSVA-LLPTVTQLYVQMMF
ALSPHG------------CLPTTSLLGLGEVALRGLETGKVIFYAE-DIPPSLMAFGAVH
SLLTSFCICTGPGCQRTGYAFTHLSLQEFLAALHLMASPKVDNDTLIHHVTLNSRWVLRT
--KARLSLLSDYLPTFLAGLASCACRPFLSQLAGRDEAWVGAKQAAILQVLRKLATRKLT
GPKVIELCRRVDETQEPELASLTAQSFHFQLPFHNFPLTCADLTSLTNILKHREAPIHLD
FEGCPLEPNCPEALVGCGPIENLS-FKSRKCGDAFAEALSRSLPTMGRLRKLGLTGSKIT
ALGIKHLVNALPSCPQLEEVSFQDNQLKDQEILKIVELLPCLPRLQRLDLSGNDISESTL
LCLAQVALTCPTIRMLQVRETDLIFLLSPAAETTAELPRTPDLQENGS-WKKEAQSRILT
LR----LQKCQLRVYDVERLINLLREGPCLEEVDLSGNQLEDEGCRLMAEATPQLHITRK
LDLSDNGLSVDGLYHVLSAMSMCRTLKE-LHISLLHKAVVLMFAQELE---EQAEPQKRA
AFLDSLMS--QMPSELPPGSQRIRLTHCGFRA-KHLQQLCEVLGRSCHLGHLQHLHLDFS
GNALGDEGAALLAQLLPELGALQSLNLSENSFTLDAVLSLAQCFSTLQWLFHLNVSLKSQ
HI---LLSGPRR-GRHICAG------GFLPELPAGAEFLA--LSPRCLPRNFSLRE--CE
LDPLSLTCLCETLKKCPGPLEVQLSCDILSDE----SLETLLRCLPLLPQLSLLQLSQTG
LS---ARSPFLLADIL----SL-C--PRVQKVDLRSLCHATLHFRSTQEQEGVCCGRFTG
CGLSQEHVVSLCERLS-KC-ED------LSQLDLSANL----LGDDGLRCLLE---CLPQ
VPISGSLDLSHNSLSQEGALYLVETLPSCSRVRE-ASVILGSEQSFRIQFSKQEEA-GKT
L--RLSEC-SFGPEHMSRLATGLSQSLQ--LMELTLTRCSLSQEQLMVLLSLVRRPAGLL
SLRVEEPWVGRAGVLALLEV-----CAQASGNVTE-ISISGTQ----------QQLCVRL
EFPHQKENTDAVAL---------------RLAYCDLETHHSLLVRQLMETCARLQQLSLS
QVNLCDDDD-A--SF-LLLQTLLPTLSELKKFRLTSSYVSTKGLAHLASGLGPCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1749)

HLEEL
DLSNNQFSE--EGTKALIGALEGKCRLKRLDLSHLPLGGSNLAMLTQGLSRMTLLQSLRL
-------------------------------------------------SRNSI-GDLGC
CHISEVVRTATSLEELGLSYNQIGDAGAQHLAAILPGLPKLRKI----------------
------------------------------------------------------------
-----------------DLSVNGIGMAGGVQLAESLALCRHLEELMLGCNALGDPTVLGL
ARELTQ--QLKILH---------LPSS--HLGPKGVLGLSQALDGHPHMEEINLAENSLA
EGVLHFC----KGLPLLRQ------IDLVSCKIDNQNAKLLAAGFALCPALEVILLSWNF
LGDEAAAELARILPQMSQLKRVDLEKNQITAWGAWLLAEGLALGSSIRVIRLWNNPIPPD
VAQRLQSQQPRLDFAFFDSKPQASRST-

----------------------MDPVDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPQSQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLHIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHITRK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLRHKTVVFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLDLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWTT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLTHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVLHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTVKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

----------------------MDPDSLHL-GSENLRGWLVRLLSTNQEWLRAKVKFFLP
DVDLASSSEALDP---EQRVILQLGELYTQGMATWQSFIHCMCMELEVPLDLEVPLLSTW
GQD-DEL-P-------------------------R-LLETGEKNQPGSQLHHGLKRP---
YQSCESSPHWK-HSRKQRL----ELAESYLQLLRTSALKHYGDGLP------GSGK----
---IYVPPVLQWSRATVPLHAPKGAI---M-GDPKTEDG--SDVSIQDLFNF-KTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARQLCHKWADGHLDHFRALFLFEFRQLNLIPHFLTLPQLLFDLYV
RPESG-PDAVFHFLEENASQVLLIFDGLDEALHQ-----------ETVEPNGSGPAFTLF
SSLCRGTLLPGCWVMATSRPGKLPACLPTEA-AMVHMWGFDLLRVKQYMNHYFSDQP-SQ
EVALTELLANGRLRSMCMVPALCQVACLCLHH-LHSTSLRGQSVA-FAPTVTQLYVQMLL
TLSP---------------LPAVSLVGLGKVALSGLETGKVIFYDR-DIPPPMMVFGATH
SLLTSFSIHTSPGHQETGYAFAHLSLQEFFAALYLMTSPTVDKGTLARHVVLNSRWVLRT
--KVRLGL-AEYLSTFLAGLASHTCRPFLSQVAQQDETWVGTRQAAVVQLLRKFAIRKLT
GPKVVELCHCVAETQEPELASLTAQSLPYQLLFHNFPLTYTDLAALVSVLEHRATPIHLE
FEGCPLEPHSPEALAGCGQVETLS-FKSRKCRDTFAEALSRSLPTMGNLKKLGLAGSKIT
ARGISHLVQAVPLCPQLEQISLQDNQLKDQEVLSIVELLPSLPQLQKLDLSHSNFSMSTL
FCLVKVAVTCPTVRTLRVTETDLVFFLSRSTETAICKSLPVLKAEGDM-AQRSPSVPHPC
SR----LQRCQLRVHHVEVLVGLLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1006)

PWLEEVDLSGNQLEDEGCRLMVEAASHLHITGK
LDLSDNELSVDGVSYVLRAVSTCRSLVG-LHISLLQKTVVLTFAQEAE---EQEGTQERV
R---------------------------------------AGFHKPCCLTSPFPF--SFS
GNALREEGAVLLAQLLPGLGPLQSLNLSENGVPLDTVFHLTQCLSTLQWVCHLEVRDK--
----------------------------LAKFSAEVQLSG--FHKHCIPRSFCLKK--CQ
LGPPSLTLLFTALEEWQGPLGVERSPKGTMWV----SVQPLS----LGGASWLEARDQTG
LS---LKSPFLLANVV----SQ-C--PRVRKVDLRSLHDATLHFRSSEEQEGVCCG-FTG
CSLSQEHVEPLCRALS-KC-DD------

PF13516 // ENSGT00860000133673_1_Domain_9 (1409, 1431)

LRQLDLTDNQ----LGDDGLRCLLG---HLSQ
MPISELLDLSHNSISQEGVLHLLGTLPSCLRAQE-ASVCL------W----------PSA
L--RLSEC-SFRPEHISRLASSLSQALQ--LTELTLTRCCLDLEQLTILLSLLRRPSGFL
GLRVEEPWVGGAGVPALLEV-----CAQASGTPLSLLSISETQ----------QQLCVQL
RFPRQEENPEAVAL---------------RSAHCDLVTHHSLLVRQLMETCAQLQQLSLS
QVNLCDASD----ATSLLLQSLLLSLCELKTFRLTSSCVSTQGLTHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1757)

HCHHLEEL
DFSNNQFGE--QAAEVLMGALKGKCRLKTLRLSHLPLGGSTPAMLTRGLSHMTLGGGTHC
-------------------------------------------------SSLLLPTAPSC
HKQADG-SGSLALLFSSLSHIQIGDAGAQHLAAILPGLPRLRKID---------------
------------------------------------------------------------
------------------LSANGISLAGGLQLAESLTLCGDLEEIRLGCNALGDPTTLTL
AQGLPQ-

PF13516 // ENSGT00860000133673_1_Domain_20 (2048, 2079)

-HLRVLH---------LQSS--RLGPEGALSLGRALDGCPHMEDISLAENKLA
NGVPRFC----KGLPLLRR------LDLGSCEIDNQTAKELAASFMLCPALEEILLSWNL
LGDEAAAELAQVLPRMGRLRRVDLEKNRITAAGAWLLAKGLAQGSGVHVIRLWNNLVPPA
MAQHLQSQEPRLDFTFFDNRTQAT----

----------------------MDSESFQL-GTENLWAWLVRLLSKNSEWLNGKIRFYLP
TMDLDCSNTAPEP---EV-IHHQIRRLYTQDQATWQSFINSLCMELDVPLELEVPLLSIW
GQK-DEF---------------------------SRQIGAGEDGHPGPLPHHGVKRP---
SQSCGSSPRRK-HCRKQQL----ELAKKYLKLLKTSARRYHGGECP------GAGHTH-A
SPQAYIPPILQWSRATAPLDAQEGAT---I-GDPDTADD--IDVSIQDLFNF-KAPKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCWRWADGQLDRFQALFLFEFRRLNMITHLLTLPQLLFDLYL
RPESD-PDAVFQYLEENAHQVLLIFDGLDEALHA-----------DSVGADNAGSALNLF
SDLCRGTLLPGCWVMATSRPGKLPACVPTEA-AMVYMWGFDGLRVEKYISHFFSDLL-SQ
ELALAELRTNERLWGMCAVPALCQVACFCLRH-LLPRSPPGQCAA-LLPTVTQLYLQMVE
TFSHNG------------ILPATSLLSLGKVAFGGLDTGKVIFSME-DIPPPLMAFGAVH
GLLTSFCIRTSPEHQETGYAFAHLSLQEFFAALYLMASDTIDKDTVTYYVTLNSHWVLRT
--KSRLGL-SDHLPTFLAGLASHTCHAFLCHLTQQDEAWVGSRQAAVVQVLRKLASRKLT
GPKMIELYHCVAETQELELARFIAQSLPFRLSFHNFPLTHADLAALANVLEHRAAPIHLD
FDGCPLEPRCPEALVGCGQVENLS-FKSRKCGDAFAEALGRSLPTMGSLKMLGLTGSKIT
ARGISHLVQALPLCSQLEELSLHDNQLKDPEVLSLVKLLPCLSKLQKLDLSRNSFSVSTL
LSSVKVAITCSAVRKLQVRESDFVFLLSPITETTVQQSEALNLQDEDS-LKKEGQSRSLE
LR----LQKCHLRVHDAEALVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

RLEEVDLSGNHLDDEGCRLVAEAASQLQIAQK
LDLSDNGLSKTGVTYVLRAVNTCGTLEE-LHISLQNNIVVLTFAQEPR---KQERNCKGG
VPLTSFAS--PVASETSRSSRSIRLTHCGFLA-KHTERLCGALRVNCQ

PF13516 // ENSGT00860000133673_1_Domain_6 (1129, 1153)

LHHL--NHLDLS
DNSLGDEGVALLAQLLPGLGPLQSLNLSRNGVSLDAVFDLTTCMSSVQWVFHLDVSLESE
HI---LLQGAGT-GRDAPAG------RCGPEFPAGAPLLA--SSPLYTSRSFRLQG--CQ
MEPLSLARLCATLEKCPGPLEVHLSCKTLSDE----SLKTLLQCLPQLPQLRLLQLSHTV
LS---SRSPFLLADVF----NL-C--PGVQKVNLRSLCHAVLHFDSKKEKEGVCFG-FPG
CSLSQEHMEPLCCALS-RC

PF13516 // ENSGT00860000133673_1_Domain_9 (1400, 1431)

-TV------LSQLDLTDNL----LDDSGLRCLLE---CLPQ
LPICGWLDLSHNSISQEGVLCILETLPSCPRVCE-VSVSLGSEQNFRICLSREKEV-GTK
L--RMCEC-NLGPEYVSRLASSLSQAQQ--LTELTLTRCHLDLPQLTNLLNLVNRPAGLL
GLRLEEPWVGHVGLLAVMEV-----CAQASGCLTE-LSLSETQ----------KQLWLRL
EFPHQEDSSEFMAN---------------RLAHCDPGTGHSLLMRQLMETCSRLQQLSLS
QVNFSDEDN----KRSRLLQNLLMSSSELKSFRLTSSCVSTESLAHLASGLR

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1749)

HCHHLEEL
DFSNNHLC

ENSGT00860000133673_1_Linker_12_13 (1749, 1795)

K--ENIELLMGALQGTCKLKRLHLSHFPLEASSLALLVQGLSCMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1891)

LQHLCL
------------------------------------------------------------
------------------RHNQIGDVGTQN

ENSGT00860000133673_1_Linker_13_15 (1891, 1901)

LAAILPRLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKL----------------
------------------------------------------------------------
-----------------DLSGNSIGPAGGVPLAKSLTHCRCLEEIILGNNALGDPTALGL
AQRLPP--QLRVLC---------LPSS--HLGPEGALCLAQALEQCPCIEEFSLAENNLA
GNVPHFC----KSLPLLRH------IDLISCKIDDQAAKHLATSLMLCPALEEISLSWNL
LGDEVAAELAQVLPQMEQLKRVDLEKNRITACGAQLLAQGLVQGSCVPVIRLWNNPIPAD
VAQSLQRQEPRLDFAFFDQQPQTL----

----------------------MDATGLQL-DSRNLWDQLVQLLCKNPEWLSTKVKFFLP
NMDLGSRSEALDP---MQYIILQLQHLWEQGLAAWQSLIHCVCMELEVPLDLEVLLLSTW
GNN-EGT---------------------------SSLLEADKEKQSGLQHYHGLHQP---
SLSLESLPQQK-HCRRQQR----ELAQKYLQLLRTFAQQHCGSGFP------DSGQ----
---AYIPPILKWSRATTPLDTQKGTN---T-GHPKTEDG--ADVSFEDLFNC-RTHKAP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
MTMLLGKAGMGKTTLAYQLRQKWAEGQLDHFQALFLFEFRQLNLITHSLTLRQLLFDLYL
SPESE-PDAVFQYLLQNANEVLLIFDGLDEALE-------------TETSPCPNSALSLF
SDLCRGKQFPGCCVVATSRPGKLPTCVPTEA-ARVHMWGFDRPRVVEYVSHFFSAQS-LQ
EAALAELQADRQLWNMCSVPALCLAICLCLHH-MLPSSPPGQGAA-LLPTMTQLYMQLML
TLSPHR------------TLPDTLLLRLGEVALRGLETQKVIFYIE-DIAPPLMAFGATH
HLLTSFRIRAGRGHWVTGYAFTHLSLQEFLAALHLVASPSVDNNTLIHHITLNSHWVLRT
--KAKLGL-SDHLPIFLAGLASRACRPFLSHVAQRDEAWVAARQTAIVQLLKRMAARRFT
GPKLVELCYCVAETQVPELAQLTAQRLPDQLAFHNFPLTYMDLATLASILEYRTVPIHLE
FEGCLLEPHCPEALTGCRQIENLS-FKSRKYGDAFVEALSRSLPTLGNLRKLGLTGSKIT
SQGIGHLVKALFHCP

PF00560 // ENSGT00860000133673_1_Domain_2 (856, 882)

QLKEISLNDNQLKDQEVLDLMEELPHLPSLQKLELSCNSIFVETL
LRLVKVAVTCPTVRTLQVRETDFTFHFSPSVEAAT-EQRAPDLQETVS-QKEETRSRSLA
LR----LQKCQLRVHHAEILTTLLQDGP

PF00560 // ENSGT00860000133673_1_Domain_4 (989, 1015)

PLEELDLSENQLEDEGCRLVAEAVPRLRIARK
LDLSDNQLSVSGLSYVLRVVSTCWALME-LHISLLYKITVLTFTHEPE---VQEGACQSA
IFLDNHVS--PVPVELPLGSWRIRLTHCGFQA-KHVEPLCKVLQESCCLRPLDHL--DLS
DNALGDEGAALLAQLLPGLGPLQSLDLSKNSMSLDAMLALAECMSSVQWVAHLDASLSNQ
HF---LLTSDTP-GRLALAG------RPLPDSPAV-------AGAQCIPRSFRLRE--CP
LEPPSLSHLCETLRKCPGPLEIHLSCEVLTDQ----SLETLLYCLSRLPQLRLLQLSETK
LT---PRSPLLLADVS----SL-C--PQLQKVELRSLYHMTLHFKSGEEQDSVSCSRFTG
CGLSQEQVEPLCYLLG-KC-RD------LWQLDLSENR----LGDDGLRCLLK---CLQQ
MPISGSLDLSHNNISQEGVLHLLEMLPYCPRIQK-VSVNLGSKQSFCIQFSKQEKA-DKM
L--RLSEC-NFQPEHVHQLAGCLSQAPQ--LVKLTLSQCFLDLQQLMVFLHLLRQPAGQC
SLRVKEPWMRTASVSTLLEV-----CTQASGSITS-ISISETQ----------QQLYVQL
EFPRQKENPEAVAS---------------RLSHCDVEIHHSL-----LETCARLQQLSLS
QVDLSDTSDTSNTSSLLLLCGLLPNLSELKIFRLTSSCVSTKGLSHLASGLSHCHHLEEL
XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXLSHMPLDSPAVATLIQGLSHMTLLQSLRL
-------------------------------------------------SGNHV-DDIGC
CHLSEALRAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

MLEELRLDHNQIGDAGAKHLATILPRLPQLKKI----------------
------------------------------------------------------------
-----------------NLSANGVGPAGGMLLATSLTLCR

PF00560 // ENSGT00860000133673_1_Domain_19 (2021, 2053)

HLEELRLGHNALGDPTVLQL
TQGLPQ--QLRVLH---------LPSS--SLGTEGLLSLGQALDGCPRIEDISLAENSLA
RSIQHLC----KGFPQLLR------LDLAYCAIDNQAAKHLIASFPLCPALEEILLSWNS
LGDEATAELAQVLPRMLRLQRIDLEKNQITARGAWLLAEGLAQGSSIQVIRLWKNPIPDD
AAERLRSQEPRLDFKFFDSQAQAPGEP-

----------------------MDSLSWQN-DEESLQQHLVGFLSKDLEWLILKVKFFLP
DLDLTPVDDLPDP---TQKVSLLLDKLRAHSLSTWRTFIHCVCMEHTMPLHLETMLLSVW
GMHSEIPSQ---------------------N---IFC---KDALPKSQLLHSGVKRP---
SSEIGSSPPRK-WSRQQQL----ELVRKYEKRLRTLFLKKYEDVPGR-TSGQWQQWPF-C
FSQTYVDPVVRPGKVAWLKEGPEKSQVETLAEPLEVEDG--ANFKVQDLFRG-QSGSGTK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 474)

VTVLLGKPGTGKSTLVQRICRKWARGELDRFSQVFLFEFRQLNLVKQELTLPQLLFEVYE
NLEEE-PGAVFQHLQENDHQVLLIFDGLDECLFPWPGRGPC--ARDSQDPFLSRPVASLF
CSLCSGSLLPGCWVVTTSRPGKIPDFLLETATSVFEVWGFDQLRIENYVNNFFQGLI-SP
ERALACLRASAQLQSLCSNPALCSIACFCLHHLLC-----QDHTIKFPTTVTQLFTQMLH
IFVGQKQGT-PGDKGTWLSKDSQALLGLGELAFKGLNEKQIVFYPG-HIPEQVVAFAATY
NLLSSFSVRTGTGQRDTCYAFVHFSLQEFFAALYLMVSPSIDSSKLRHHFYLKSRWPLRT
--EAKTEL-LDRFHTFLSGFSSQTYLSFLTRLSQQGRAWVSTKQAAVRQVLRGLATQSLT
GPKMIELCHCVGETQDPELMGQAGRSLPFSLDFHNFPLNHSDLTALTSLINHAPASIYLN
FSGCSLESQCLNALTGCGKIESFR-VRSRKCRDAFAEALSKILPTMGNLKKLELTGNNIS
VQGIDHLAQAFTDCLQLEEINLQDNRLNDSSCLKIITILHKMQRLQKIDLSQNAVSVQTV
LALAKEAVSYPRVTTLEIRQAQMILLFFVSSGKALEMQRSQNVKKNEPSDKIVTQDRKLT
FR----LQKCNLAVHHAKEIAEMLKHRPYLEEVDLSGNHLEDEGCRELAEALPDLQIAKQ
FNISDNGLSESGVYYLLTSANACKNVME-LDISLKNKTAVFKFAGDQEKDQAPLGAAVSN
PQLSSNSSEPVSSL----SARVIRLRHCGFQCR-ELEKLCLKLGNCSHL--------DLS
NNRLGNKGIEKLIQLLPSLRSLQFLTLNDNRVSLKAVFCLASTFSDLEWVHEVDISLGRQ
QSIHVRFLERTR---KRSVS------EEWTKQKTQQ--ESL-EWGAQFPKSFCLRE--CQ
LEPPVLEKLIQILKTCQGLLEIKFSHVTMNDQ----SIGMLLNHLPQFHNLNLVQFSQTT
LS---LNSVFSLASAI----SL-C--EQIQKMEVRSLKYACLYFTPGK-RKGVSCG-LTD
CCINQMDMKQLCCILG-QC-KD------LSHLNLSGNL----LGDEGLKYLLE---HLPQ
MNLSGSLNLSHNGISEEGALLFTVALGTCRQAHE-VSVSLNLEQKLLIHFTEHQEP-RKT
L--RLTGF-NLQQEQIKKLATLVGQVPK--LNDLILATNTMSLAGLQLLLNSVRMPSGIL
RISVEEPWVTRTSVTTLLEA-----SVQASGNITK-ISICRQQ----------SLLQIEE
TFPQKTGNFAADTLRPIQCDQGASLTFPYDLSQCDQGDNQTLVLRQMVEKYMRLQELSWS
QVYLCDTSS-------QLLKTLFPSLLELKKFSLTASTVSPEGVCHVASGLSHCNTMEEL
DLSKNEFSV--EGTRVLIGALEGKCQLRSLNLSFLQLDNLALSELAQRLQGMSLLQKLDL
-------------------------------------------------SHSGL-SSESC
FSLSDSLKDATNLKDLNLSHNKIEDAGVQHLSAILPKLLQLSKL----------------
------------------------------------------------------------
-----------------DLSWNSISPAGGRTLAEALACCEQVEELHLGANTMGDLMAIRL
AQNLPP--HLKILY---------LCSN--KIGAKGTLSLGQALVRCQWIEEISLAENIFA
EWILPLS----KGLLKLRK------INLTSCRINDQMIKPLASSLVLCHDLEEILLAWNS
LGNEGATELAYILPQMKALKKFDLEGNQIGSLGAQLLAKGLAKNPGIQVIRLWKNPVPKD
TAQLLQGQDPRLNFS-------------

----------------------MDPVGLQL-GTKNLWSWLVRLLSKDPEWLNSKMKFFLP
NTDLDSGNETSDP---EQRIILQLRKLHVQGLATWQSFIHCVCMELEVPLDLEVPLLSTW
GCD-DEL---------------------------TSQLRAEEKSRRESQLHHGLKRP---
HQSCGSSPRRK-QYRKQQL----ELAKKYLQLLRTSALQRYGSQIP------GSGQPH-A
FHQAYVPPILRR--ATAPLDNQCGTI---M-GNPRVEDG--TDVSISDLFNT-RTNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTILLGKAGMGKTTLAHRLCRKWAEGHLDCFQALFLFEFRQLNLITRFLTLPQLLFDLYL
SPESD-PDAVFQYLEDNADQVLLIFDGLDEAL-------------QPEDPDGPGPVLALF
SGLCNGTLLPGCWVLVTSRPGKLPACLPTEA-AVVHMLGFDGPRVEEYVNCFFSTQP-SR
EGALWELQTNGRLRSLCAVPALCQVACLCLYH-LLPDHAPGQSAA-LLPTMTQLYMQMVL
TLSPRG------------HLPTTSLLGLGKVALRILETGKVTFYAR-DIPPSLMAFGATH
SLLTSFCICTGPGHQQTGYAFTHFSLQEFLAALHLMASPEVDKDLLTQHVTLNSRWVLRT
GPKAKLDL-SDHLPTFLAGLASCTCRPFLSHLAQRGEDWVGTKQAAVVQALKKLATRKLT
GPKVVELLHCVDETQEPELASLTAQSLPSQLPFHNFPLTYTDLAILTNILEHREAPIHLD
FEGCTLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFQDNQLDDQVVLNIVEVLPYLPRLRKLDLSGNSICVSTL
LCLTKVAVTCPTISMLQAREADLIFLLSPPMETTAELQRAPDLQESDG-QRKEAQSRSLT
LR----LQKCQLQVHDAETLIALLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAVSQLHITRK
LDLSDNGLSAAGVHCVLRAVHACWTLEE-LHISLLHKTVVFMFAQDPE---QQEGPQNRA
ASLDSLML--QMPSELPLSSRKMRLTHCGLQA-KHLEQICKALGGSCHFGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1152)

HLDFS
GNALGDEGAAQLVQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWVFHLDISFERQ
RI---LLRGNKT-GRGIWTT------GSLPDLPAAAEFSG--FRRRCIPRSLCLSE--CS
LEPLTLTRLCATLEACPGPLELQLSCEVLSDQ----SLETLLHCLPRLPQLSLLQLSQTG
LS---PRSPFLLADIF----SL-C--PQVKKVDLRSLHHASLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCWLLS-KC-ED------LSQVDLSVNL----LGDGGIRSVLE---CLPQ
VPISGSLDLSHNNASQESALCLVETLSSCPRVRE-ASVNLGSEQSFQIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLAAGLSQSLQ--LTELMLTQCCLGQEHLTTLLSLVQRPAGLF
SLRVQEPWVDQAGVLSLLEV-----CAQASGNVTE-ISISETQ----------QQLRVQL
EFPRQEENPEAVAL---------------RLAHCGLGTHHSLLVRQLIDTCARLQQLSLS
QVNLCEDND-A--SS-LLLRSLLLSLSELKKFRLTSSRVSTEGLAHLASGLGHCHQLEEL
EWSNTEFDE--EGTKALMRALEEKWTLKRLDLSHLLLNGSTLALLTRGLSHMALLQSLRL
-------------------------------------------------KRNSI-GDVDC
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVRYLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANSISPAGGVKLAESLALCRRLEELMLGCNDLGDRTALEL
ARELPQ--HLRVLH---------LPSS--HLGPNGALSLVQALDGSPHVEEISLAENNLA
EGVPHFC----KGLPLLRR------IDLVSCKIDNQTAKLLTSSFTLCPALEVILLSWNL
LGDEAAAELAQVLPRMGRLKRVDLEKNQITARGAWLLAEGLAQGSSVQVIRLWNNHIPCN
MAQCLQSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPDSPHL-GSENLCDLLVRLLITKQEWLRAKVKFFIP
DVDLASSDKVSDP---VQRVILQLGELKAQGPATWQSFIHWVCMDLEVPLDLEVRLLSTW
GQD-DEF-P-------------------------K-LLETGEESQPGPQQPHGLKRP---
CQRCESSPRRK-HCRKHRL----ELAQTYLQLLRTSALQHYGDGFP------GPGK----
---VYVPPILQWSRATVPLDTQEGAV---L-GNPKTEDG--SDLSIQDLFNF-KTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARRLCHKWADGHLDHFQALFLFEFRQLNLITHLLTLPQLLFDLYL
RPESG-PDAVFQYLEENANRVLLIFDGLDEALHPCSSM-------EAVGPSGSGPALTLF
SSLCRGTLLPGCWVMTTSRPGKLPACLPKEA-AMVHMWGFDQLRVEEYVNHYFSDQP-SQ
GVALTELLANRHLRSMCVVPALCQIACLCLHH-QFSASLPGQSVAPPLSTMTQLYMQMLL
SCMP---------------RPATSLVGLGEVALSGLETGKVIFYDR-DIPPPVMAFGATH
NLLTSFCIRTSPGHQETGYAFAHFSLQEFFAALHLMTSPTVDKATLARHVILNSHWVLRT
--KARLGL-ADHLPTFLAGLASHTCRPFLSQVAQQDETWVGTRQAAVVQLVSKLATRKLK
GPKVVELCHCVAETLEPELASLTAKNLPDQLPFHNFPLTYTDLTALASVLEHRATPIHLE
FEGCPLEPHCPKALVDCRQVETLS-FKSRKCGDNFAEVLSRSLPTMGSLKKLRLAGSKIT
ARGISHLVQALPLCPQLEEVSLQDNQLKDQEVLSIVQILPSLPRLQKLDLSHSNFSISTL
LFLVKVAVTWPTVRALQVREAELIFLLSPSTETAADLQRAPELPEKHS-QRKETQSRTLV
LR----LQKCQLRVHHAEVLIDLLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1009)

PWLEEVDLSGNQLEDEGCRLLAEAASHLHITGK
LDLSDNELSVDGVPCVLKAVNTCQSLAE-LHISLLQRTVVLTFAQEAE---EQQGTQERA
AFLDSLTS--LTASEPP---REIRLTRCGFGA-KHLEKLCEALEGSCCLARLG

PF13516 // ENSGT00860000133673_1_Domain_6 (1134, 1153)

HL--NFS
GNALRDEGAMLLAQLLPGLGPLQSLNLSENGLSLDAVFHLTQCLSSLQWVWHLEVSFESQ
HIL---LRGDKR-SRDKLAG------GSLPEFPAGAQLSG--FRQHCIPRSFCLKE--CQ
LGPQSLTRLCTALGECPGPLEVQLSCKDLSDQ----SLETLLRCLPRLPQLSLLQLSQTR
LS---LKSPFLLADVV----SQ-C--PRVQKMDLRFLNNATLHFRSSNEQEGVCCG-FTG
CSLRREHVEPLCRALR-KC-DN-----

PF13516 // ENSGT00860000133673_1_Domain_9 (1408, 1431)

-LRQLDLTANV----LGDDGLRCLLD---HLLQ
MPISGVLDLSHNSISQEGVLYLLGALPSCPRVRE-ASVNLGSTQNFWVHFSKQEEA-GMT
L--RLSEC-SLGPEHMPRLASSIGRALQ--LTELTLTRCGLDLKQLAILLSLVRRPSGLL
HLRVEEPWVGEAGVPALLEV-----CAQASGS-ITVISISET------------QLCVQL
EFPRQEENPEAMAL---------------RLAHCDLGTHHSLLVRQLMETCARLQQLSLS
QVNLCDANN----ATSLLLQSLLLSLCELKTFRLTSSCVSTQGLTHLAAGLGHFHHLEEL
DFSNNRVGE--QGTEALIGVLKGTYRLKRLHLSHLPLGGSTLAMLTQGLSHM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1892)

SLLQ----
------------------------------------------------------------
-HLC-------------LSHNQIGDAGAQHLAAILPGLPSLRKID---------------
------------------------------------------------------------
------------------LSANGISLAGGLPLAESLTLCRHLEEVRIGRNALGDPTALTL
AQQLPQ-

PF13516 // ENSGT00860000133673_1_Domain_20 (2048, 2079)

-HLRVLH---------LQSS--RLGPEGALSLGQALDGSPHVEDISLAENKLA
RGVPHFC----KGLPLLRR------MDLGSCEIDNQTAKGLAASFVLCPALEEILLSWNL
LGDEAAAELAHVLPRMGRLKRVDLEKNRITTAGAWLLAKGLAQGSGVHVIRLWNNLVPAA
VAKHLQSQEPRLDFAFFDNQPQAPWGN-

----------------------MDAESYRL-GNENLWAWLVELLSKKPEWLSAKVRFFLP
TLDPDCSNEAPIS---EV-THHQLNRLFAQGPATWESFIYTLCIELEVPLSLEVPLLSIW
GQK-DEF---------------------------SKQLGACEESHPGPELHHGVKRP---
FQSYGSSPRRK-HSRKQQL----ELVKKYLKLLRTSAQQCHGGQCP------GAWNAR-D
SPQTYIPPIVQWSGTSAPLDAQEGAR---IGGDPEAADS--TDVSIHDLFNF-KAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVVLGKAGMGKTTLAHRLHWRWAHGQLDRFQAVFLLEFRQLNMITQLLTLPQLLFDLYL
SPESDDADAVWQYLEENAHQILLIFDGLDEALHT-----------DSVGTDNAGSALTLF
SELCHGDLLPGCWVMTTSRPGKLPSCVPTEA-AMVYMWGFDGLRVEKYVTHFFSDLL-SQ
ELALKEMRANERLRGMCAIPALCRVACFCLRCSLLSGSSPGQSSA-LLPTITQLYLQMVK
TFSSSG------------TLSATSLLGLGNVALRGLVTGKVIFSVE-DIPPQLMALGAVH
SLLTSFCIRTRSGHKEIGYAFVHLNLQEFFAALYLMASDTVDKDTLINYVTLNSHWVLRT
--KAKPGL-SDHLPTFLAGLASHTCHTFLCHLAQQDEAWVGSRQATVIQVLRKLASRKLT
GPKMVELYHYVAETQDLELARFVAQSLPFDLSFHNFPLTRADLASLANILEHRDGPIHLD
FDGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAEALCRSLPTMGSLKMLGLTGSKIT
AQGISHLIQALPLCSQLEEVSLHDNQLKDPEVLSLVDLIPCLRKLQKLDLSQNSFCMSTL
LSSVKAAITCPTVRKLQVRESELIFFLSPVPETATQQSGASDAQGEDS-PK-EGQSRNLQ
LR----LQKCQLRVHDAKALVELFQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1005)

RLEEVDLSGNHLKDEGCRLVTKAVSQLHIAQK
LDLSDNGLSQTGVTYLLKAVSTCGTLEE-LHISLLTNTVVLTFAQELR---DQEGSFKRG
AQLTGFMS--PVTSELSQRSRRIRLTHCGFLA-EHTEKLCEALRVSCQSHPL--DHLDLS
DNFLKDKGVILLTQLLPRLGPLKSLNLSRNDFSMDAVFSLVLCMSSLQWLFHLEVSLESD
CI---FLRGAGT-SRLSPSPCPRDALAGGPEFPAGAQLLE--LSQRCTSRSFCLQE--CQ
LESLNLAYLCDALEKCPGPLEIQLRLKSISDHWNSVELRVISSCLPPCPTLFLHRLTHTV
LS---SRSPFLLADIF----NL-C--PWVQKVNLRSLSHAVLHFNSNEEHEAVCCG-FPG
CSLKQEHMETLCCALS-KC-KA------ISQLDLTDNL----LDDSGLRCLLG---YLPQ
LPISGGLTSVTTVSLQEGVLYLLETLPSYPKYPRGLCESLGTKQIFRMHFSKEEGT-GTI
L--RLCEC-SFSTEQVSRLTSNLSH-QQ--LTELWLTKCGLDPPQLTTLLNLVNRPAGLL
DLRLEEPWVGYAGLPALMEV-----CAQASGCLTE-LSISESQ----------EKLWLQL
EFPRQEDHSEAMAL---------------RLAHCDLGTDHGLLMRQLVETCARLQQLSLS
QVSFSDDDG----TRSRLLQNILISSCELKSFRLTFSNVSTESPAHLASGLEHCHHLEEL
DFSNNSLCK--EDTELLIGALQRTCRLKRLHLSHLPLETSSLDLLVQGLSNMTLLQDLCL
------------------------------------------------------------
------------------KHSQIGDMGTQHLAAILPRLPGLRKLEEPWPLSQASTGEGKA
LPVLM--PRTCDLLC-----------------------PVLWVFVL--HQEGGVAASLMQ
MWGMREERGSNKL-PFHSLSGNRIGPAGGMQLVKSLTHFKNLEEIILGNNTLGDPTALEL
AQRFPP--QLPRLS---------LTSS--HLGPEGALCLAQALEQCPHIEEVSLAENNLA
GGVPHFS----KRLPLLKQ------INLVSCKIEDQAAKHLATNLTLCPALEKLLLSWNH
LGDEMAAELAQVLPQMGQLKRVDLEKNQITACGAQLLAQGLVHGSCVPVIRLWNNPIPAC
VAQSLQSQEPRLDFSFFEQQPQ------

----------------------MDPVSLQL-GTKNLHGYLVRLLSRNLGWLDAKVKLFLP
SVDLGSGYQALDP---TQRVILQLQKLHAQGPTTWKSFIQCVCMELDVPMDMEVLLMSTW
GHE-DGF---------------------------SSLLEIDEESQSDSQLHPGLKRT---
HQSCGSSPRPK-QFRKQQQ----ELAKRYLQLLRTSAQQRYGNRTP------GPGQPL-A
FHQAYVPPILKWSRASAPFHTQEGAT---T-GNPKAEDG--TDVNVRDLFST-KASKGPR
VT

PF00004 // ENSGT00860000133673_1_Domain_0 (303, 445)

VLLGKAGMGKTTLAHRLCQKWADGQLDRFQAVFLFEFRQLNLITGSLTLPQLLFDMYL
RPEAS-PEAVFQHLKENAEGILLIFDGLDEILQPCSDK-------ETEDPEDPASALTLF
SRLCRGTLLPGCSVMATSRPGKLPACLPTEA-ATVHMWGFDGPRVEEYVNHFFSDQP-SQ
EAALAELQMDRHLWSMCAVPALCRVACLCLHH-LLPGRSRGQSAA-LLPTMTQNYMQMLL
TLNPQG------------VLRAEPLLGLGEVALSGLESGKVIFSAG-DIPASTLDFGAAL
GLLTSFCVCLGPGHRDTGYAFSHLSLQEFFAALHLLASPQVDREALSQHVTLHSRWVQRT
--KARLGLSD-HLPTFLAGLASRACRSFLSLLAEREEEWVAAKQEVVLQALKKLATRRLT
GPKVVELCHRVGETQDPELASFMARSLPQQLPFHNFLLTYADLASLTSILGHRDGPIHLD
FEGCPLEPRCPETLAGCGQVENLS-FKSRKCGDAFAEALSKSLPTMGSLKKLGLAGSKIT
AQGISHLVQALPFCPQLEEVSFQDNQLKDREVLNIVEVLSCLPRLQKLDLSRNNVSVSTL
LSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGNAN-QRKEAQRRSLA
LR----LQKCQLGVHDVEVLIAQLREGPQLDEVDLSGNQLKDKGCQLMAEAAPQLHITKK
LDLSDNELSVAGVLGVLSVVNTYQTLTE-LHISLLHKTVVFTFAPELE---EQEGIQKRA
TFPDSLMF--QMSSEPSLRSPRIRLTHCALQA-QRLELLCKALGGSCRLSH---L--DLS
GNALGDEGVALLARLLPGLGSLQSLNLSENHLSLEGVCSLTQCFSTLRWLLHLEFSSASQ
HV---ILRGDKR-GRDLLAA------GSLPEFRAGAR-LG--SGQRHVPRSFCLKE--CQ
LEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQ----SLETLLYHLPQLPQLSLLQLSQMQ
LP---PESPLLLADLF----SL-C--PQVQKVDLRSLRHLTLHLRSSEEQEDRCCW-FTD
CGLRQEHVEPLCGLLS-KC-ED------LHQLDLSANL----LGDDGLRCLLE---CLPK
VPISGSLDLSHNSMSQESVLCLVEALPSCPRLRE-ASVNLGSKQSFWIHFSRQEET-GKT
L--RLSEC-HFKPEHMPRLAASLSQALQ--LTELTLTWCFPGLEQLTVLLGLLTWPTGVL
TLRVEEPWVGRVGVLTLLEV-----CAQASGNITG-ISISETQ----------KQLCIQL
EFPHQ-ENPEAVAL---------------RLAHCDLGTQQNLLARKLMETCARLRQLSLS
QVNLCDASS-------LLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHLLEEL
DLSNNQLGD--EGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRL
LLENGQKGLGPSPRTALHPKLIHLKEAPAQHLQVPLLLTEASWPCFSSLSKSNI-DDVGC
CHLSKALRAATSLEELSLSHNQIGNIGAQDLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGPAGGARLAESLTLCRHLEELMLGCNALGDCTALGL
AKGLPQ--HLRVLH---------LPSS--HLSPEGVLSLGQALDGCPHVEEISLAENSLA
GGVPHFH----QGFPVLRK------LDLVSCEIDNQTAKPLAASFVLCLALEEITLSWNL
LGDEAAAELARVLPQMGRLKRMDLEKNQITAYGAWLLAEGLAQGSGIQVIRLWNNRIPPD
MAQHLQNQEPRLDFAFFDNQPQVIPRGT

----------------------MDSESLRL-NTENLWTRLVSLLSKNSEWLSAKVRFYLR
TVDPDGS-KALDP---ES-IDVQLRRLHTQSLATWESFIHSLCMELDVPLELEVLLWSIW
GSK-DEF---------------------------SKKLGAGEDSHPEPPLHHGVKRP---
FQSYGSSPRRK-HCRKQQL----ELAEKYLKLLKTSAQQYHGGECP------GARRTH-A
SPQVYIPPILQWSRGTAPLNVQEGAT---K-EDPEATDD--TDVSFQDLFNF-KAPKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARRLCWRWADGQLDCFRALFLFEFRRLNMITHSLTLPQLLFDQYL
SPESD-PDAVFQYLEENARQVLLIFDGLDETLHA-----------SSTGADNTGSAFALF
SDLCRGTLLPGCWVLATSRPGKLPACVPTEA-AMVYMWGFDGQRIEKYVSHFFSDLL-LQ
ELALAEMRANERLRGMCAVPALCRVACFCLGR-LLPGSPPGQSTA-LPPTVTQLFLQMVE
TFSLHG------------TLPATSLLGLGKVALRRLDIGKVIFSVEKDISPCLMAFGAAH
SLLTSFCIRTSPEHQEIGYAFAHLSLQEFFAALYLMASDTVDKETLTYYVTLNSHWVLRT
--KARLGL-SDHLPTFLAGLASHNCRAFLCHLAQQEEAWVSSRQAAVVQVLRKLASRKLT
GPKMIELYHCVAETQELELAQFTAQNLPFQLSFHNLPLTRADLAALANILEHRVAPIHLD
FDGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAEALGRSLPTMGSLKILGLTGSKIT
AQGIRHLVQALPLCFQLEEVSLHDNQLKDPEVMSLVELLPCLPKLQKLDLSRNSVSVSAL
LSAVKVAIMCPTVRKLQVGESDFIFLLSPITETAVQQSGASSLQDKDS-LKKERQSQSLE
LR----LQRCQLRVHDAETLVELLQKGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1006)

RLEEVDLSGNHLEDEGCRLVAEAASQLRIAQK
LDLSENGLSKTGVTYVLRAMRTCGTLKE-MHISLLTSTVVFTFAQEPR---EQEGSCKTG
APLTSFAS--SVTSEMSGSSRRIRLTQCGFLA-KHIERLCGALRANCEL

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1153)

HHL--DHLDLS
NNSLGDEGVALLAQLLPGLGPLQSLNLNRNGVSLDAVFGLITCMSSGQWAFHLDVSLEND
HV---L-LGAGT-SRDALAG------RCGQELPAGAPLLA--GSQRCTSRSFSLQG--CQ
LEPRSLACLCAALEKCPGPLEVNLSCKTLCDE----SLKTLLQCLPQLPQLSLLQLNHTV
LS---SKSPFLLADIF----NL-C--PRVQKVTLRYLCDAALHFGSKEEQESMCFG-FPG
CSLGQEQVESLCCALS-SC-KG------

PF13516 // ENSGT00860000133673_1_Domain_9 (1409, 1431)

LIQLDLRDNL----LGDGGLRC

ENSGT00860000133673_1_Linker_9_10 (1431, 1447)

LLE---CLPQ
LPISGW

PF13516 // ENSGT00860000133673_1_Domain_10 (1447, 1462)

LDLSHNGISQEGVLCLLETLPSCPRVCE-VSVSLDSEQDFRIRLSEEEEA-GTI
L--RLCEC-SFSPEHISRLAHSLSQAQQ--LTELWLTRCHLDLPQLTNLLSLVNRPAGLL
GLRLEEPWVVHISLPAVMEV-----CAQASGCLTE-LSLSET------------QLWLWL
EFPHQEDNSEAMAN---------------RLAHCDLGTDHSLLMRQLMETCPRLQQLSLS
QVNFSDDDT----TKSRLLQNLLLSSCELKTFRLTFSCVSTESLVHLASGLGYCHHLEEL
DFSNNHLCE--ENIELLMGALQGTCRLKRLHLSHIPLEVSSLALLIQGLSHMTLLQHLSL
------------------------------------------------------------
------------------RHDQIGDAGTQNLAAILPKLP

PF13516 // ENSGT00860000133673_1_Domain_15 (1900, 2013)

GLRKL----------------
------------------------------------------------------------
-----------------DLSGNSIGPAGGVPLAKSLIHCGCLEEIILGNNALGDPTALGL
AQRLPP--QLRVLC---------LPSS--HLGPEGALCLAQALEQCLHIEKLSLAENNLA
GRVPHFR----KSLPLLRQ------IDLISCKIDDQVAKHLAASLMLCPALEEILLSWNF
LGDEVAAELAQVLPQMGQLKRVDLEKNRITACGAQLLAQGLVHGSRVPIIRLWNNPIPAE
VAQRLQSLEPRLDFAFFDQQPQAL----

MRPSPWGPWSTYHERGDQGRLLMDPVGLQL-GNKNLWSCLVRLLTKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKRQPESQLHHGLKRP---
HQSCGSSPRRK-QCKKQQL----ELAKKYLQLLRTSAQQRYRSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTPEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTPSELLFDLYL
SPESD-HDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGPVLTLF
SDLCHGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-SR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTRTQLYMQMVL
ALSPPG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DITPPLIAFGATH
SLLTSFCIRTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARLCL-SDHLPTFLAGLASCTCRPFLSHLAQDNEDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSKSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL
LCLARVAVTCPTVRTLQAREADLIFLLSPPTEKTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDVEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSVAGVHCVLRAVSACWTLAE-LHISLQHKTVVFMFAQEPE---EQKGPQERT
AFLDSLML--QMPSKLPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---LHLDFS
GNALGDEGAAQLAQLLPGLGALQSLNLSENGLSLDAVLGLAQCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSLPDFPAAAEFLG--FRQRCIPRSL--------
-----------------------LSCEFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---LKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTG
CSLSQEHVESLCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSISQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSGEDQA-GKT
L--S--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------LSHLLLNSSTLAFLTHGLSHMTRLQSLRL
-------------------------------------------------NRNSI-GDVGC
CHLSEALRAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1895)

SLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISSAGGVQLAESLVLCRHLEELMLGCNALGDPTALGL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDMVSCKIDNQTAKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITALGACLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPVDFQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGGEGKSLPESQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKSGMGKTTLAHRLCQKWAEGHLDYFQALFLFEFRQLNLITRFLTPSQLLFDLYL
SPELD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPTGPDGPGSVLTLF
SRLCHGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSTQP-SR
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGRSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGELALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLNL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCINTKQAAVVQVLKKLATRKLT
GPKVLELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSICVSTL
LCLARVAVTCPTIRMLQARKADLIFLLSPPTETTAELQRAPDLQKSDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LRISLQHKTVVFMFAQEPQ---EQEGPQERA
AFLDSLTL--QMHSELPLSSRRMRLTHCGLQA-KHLGQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLSHLCATLKECPGPLELQLSCEFLSDQ----SLKTLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSISQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-RKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
ILRVQEQWTDRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRREENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-A--SS-LLLQNLLLSLSELKTFRLTSSCVNTRGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSAFTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSMNSISPAGGMQLAESLVLCRHLQELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMCRLKRVDLEKNQITATGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQPQAPWGT-

----------------------MDPISIQL-GTRNLWSWLVSLLSKDPKWLSDKMSVFFP
NTDLGSQNEIPDP---EQRVILQLRKLHAQGLDTWQSFIHCVCMELEVPLDLEVPLLSTW
GSE-DGF---------------------------PSQLGDGEESQPESQLHHGLKRP---
HQSHGSSPRRK-QSRKQQL----ELARRYLQLLRASAQQRYGDRLS------GSGQPL-G
SHQPYIPPVLQWTRATVPLDTQQGAA---M-GDIKAEDG--TDVNIWDLFNP-RTKRGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGTAGMGKTMLAHRLCQKWAEGQLDHFQALFLFEFRQLNLLTSFLTLPQLLFDLYL
SPESG-PDAVFQYLTENAEQVLLVFDGLDEALQPCSGR-------DTGSPEGLGPALTLF
SGLCRGTLLPGCWVMATSRPGKLPPCLPTEA-AVVQMWGFDSPRVEEYVSRFFSAQP-SQ
EGALAELRVNGRLRSMCAVPALCRIACLCLRH-LLPGSAQGQSVA-LLPTVTQLYMQMVL
ALGPPG------------CLPTTTLLGLGEVALRGLETGKVVFYAR-DIPPSVMAFGTAH
SLLSSFCVCTGPGHRQTGYAFTHLSLQEFFTALYLMASPEVDKDTLTHHVTLNSRWVLRT
--KARVGL-SDHLPTFLAGLASCACRPFLSQLAERDEAWVGTRQAAVVQVLRKLATRKLT
GPKVIELCRCVDETQEPELAGLTAQSLRCHLSFHNFPLTCADLTSLTNVLERREAPIQLA
FEGCPLDPHCPEALVGCGQVENLS-FKSRKCGDAFAEALSRSLPTMGRLQKLGLAGSKIT
AQGIRHLVKALPLCLQLEEVSFQDNQLKDQEVLNVAEVLPCLPRLQKLELSGNSISVSTL
LSLAKVAVLCPTVGTLQVREADLIFLLSPRAETAVELQRAPDPQENDS-QRKAAQSRSLT
LR----LQKCELQVHNVEALIALLLEGPP

PF13516 // ENSGT00860000133673_1_Domain_4 (990, 1007)

LEEVDLSGNQLEDEGCRLMAEAALRLRITRK
LDLSDNGLSVAGLHCVLGAVSTCRTLAE-LHISLLHKAVVLTFAQKSE---EQEGPQKSA
AFLDSLMS--QVPSELPLSSRR----------------------------------ISFS
GNALGDEGAALLAQLLPGLGALQSLDLSGNGFSLDAALTLARCFSALQWLFHLDISLESQ
RV---LLTGARR-GRDIRAG------GFSPEIPAGAEFSG--FGQRCAPRSFCLRE--CQ
LEPPSLTRLCATLEESPGPLEVQLSCAVLSDQ----SLETLLHCLPRLPHLSLLQLSQTG
LP---AKSPFLLADIL----GP-C--PRVQKVDLRSLHHAALHFRPSHEREGVCCG----
---------------------------------LSANL----LGDDGLRCLLG---CLPR
VPISG

PF13516 // ENSGT00860000133673_1_Domain_10 (1446, 1462)

SLDLSHNGISREGALHLVETLPACSRVLE-ASVNLGSEQSFRIRFSKQEEA-GKT
L--RLSEC-SFGPEHVPRLATGLSQSLQ--LTELTLTQCCLGREQLMVLLSLVRRPAGPL
CLRVEEPWVGRAGMLALLEV-----CTQASGNITE-ISISETQ----------QQLRIQL
EFPHQEEDPEAVAL---------------RLAHCDLGTHHNLLVRQLMETCARLQQLSLS
QVNLCDDDD-A--SV-VLLQSLLLSLSELKKFRLTSSCVSTKGLTHLASGLS

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1749)

HCHHLEEL
DLSNNQFFE--EGTEALVRALEGKCRLKRLDLSHLPLGGSTLAVLTQGLSHMTLLQSLRL
-------------------------------------------------SRNSI-SDLGC
CHLSEALRTA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELGLSHNQIGDAGAQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

AAILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSANDIGPAGGVQLAESLTLCRHLEELMLGHNALGDPTALGL
AQELPQ--HLRVLH---------LPSS--HLGPEGALSLGQALDGCPHVEEISLAENSLA
EGVPHFR----KGLPLLRQ------MDLVSCKIDNQTAKLLAASFLLCPALEVILLSWNL
LGDEAAAELARVLPQMSRLKRVDLEKNQITVRGAQLLAEGLAQGSGIQVIRLWNNPIPAD
MAQCLQSQEPRLDFAFFDKAPQNT----

----------------------MDPIGLQL-GTKNLWSSLVRLLSKDTEWLNSKMKFFLP
NTDLDSRNEASDP---EQRIILQLRKLYVEGLATWQSFIHCVCMELVVPLDLEVLLLSTW
GCE-DGL---------------------------TSQLGAEEKSRRESQLHHGEDWS---
C-----------RGRKGVV----KLAKKYLQLLRTSALQRYGSRIP------GSGQPH-A
FRQAYVPPILRR--ATATLDTQGGVI---M-GNPRVEDG--TDVSISDLFNT-RTNKGPK

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 475)

VTILLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLPQLLFDLCL
SPESD-PDAVFQYLKENADQVLLIFDGLDEALHM-----------DPEDPDGPGPVLTLF
SGLCHGTLLPGCWVLATSRPGKLPACLPSEA-AVVHMLGFDGPRVEEYVNCFFSTQP-SR
EGALGELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSAA-LLSTMTQLYMQMVM
ALSPRG------------HLPTTSLLGLGEVALRNLETGKVTFYAR-DIPPPLMAFGATH
SLLTSFWICTDPGHQQTGYAFTHFSLQEFLAALHLMASPKVDEDLLTQHVTLNSRWVLRT
GPKAKPDL-SDHLPTFLAGLASCTCRPFLSHLAQRGEDWVGTKQAVVMQALKKLATRKLT
GPKVVELLHCVDETQEPELASLTAQSLPCQLPFHNFPLTYTDLAVLTSILEHREAPIHLD
FEGCTLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLKMLGLVGSKIT
ARGISHLVKALPLCPQLEEVSFQDNQLDDQVVLNIVEVLPYLPRLRKLDLSGNSICVTTL
LCLTKVAVTCPTISMLQARKADLIFFLSPPTEATAELQRDPDLQESDG-QRKEAQGRSLS
SGTLEGSIKCQLQVHDAETLIALLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAVSELHITRK
LDLSDNGLSAAGVHCVLRGVCACRTLAE-LHISLLHKTVVFMFAQDPE---QQEGPQNRA
EFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLDH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDLS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGFARYFSTLQWVFHLDISFERQ
CI---LLRGDKT-VRGIWTT------GSLPDLPAAAEFSG--FRRHCIPRSLCLSE--CP
LEPLTLTHLCATLEECPGPLELQLSCEVLSDQ----SLETLLHCLPRLPQLSLLQLSQTG
LS---PRSPFLLADIF----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCWLLS-KC-ED------LISAGLEG------------QSVSG---CLPR
C-YLGSLDLSHNNASQESALCLVETLSSCPRVRE-ASVNLGSEQSFQIHFSKEDQA-GKT
L--RLSEIAAFCPEHVSRLAAVGAR----------QPRCQLGPPGK--------------
-------------------A-----AQLHVGYHSL-LSISETQ----------QQLRVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVRQLMETCARLQQLSLS
QVNLCEDDD-A--SS-LVLRSLLLSLSELKKFRLTSSRVSTKGLTHLASGLGHCHHLEEL
EWSNTEFDE--EGTKALMRALEEKWTLKKLELSHLLLNGSTLALLTHGLSHMTLLQSLRL
-------------------------------------------------NRNSI-GDVDC
RHISEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSYNQIGDAGVRYLATILPRLPELRKI----------------
------------------------------------------------------------
-----------------DLSANSISPAGGVKLAESLALCRRLEELMLGCNDLGDRTALEL
ARELPQ--HLRVLH---------LPSS--HLGPNGALSLVQALDGSPYMEEISLAENNLA
EGVLHFC----KGLPLLRR------IDLVSCKIDNQTAKLLISSFTLCPALEVILLSWNL
LGDEAAAELAQVLPRMGRLKRVDLEKNQITARGAWLLAEGLAQGSSVQVIRLWNNHIPCN
MAQCLQSQEPRLDFAFFDNQSQAPWGT-

----------------------MDPDSLQL-GTEHLWNWLVRLLSKDSEWLNAKVKFFLP
KMDLCSGDKAQDA---TQGVILQLRRLHAQGRATWQAFIHCVCMELDVPLDLEVPLLSTW
GHG-VAF---------------------------PSQLEASEESQPASQLQHGLKRP---
YQSCGSSPRPK-QCKKQQL----ELAQRYLKLLKTSTQQRYGSKIP------GPGQPL-A
FHQAYIPPILQWSRTPTPFRTQEGMA---P-GDPKAEDG--ADVSIRDLFST-RADKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQRWADGQLDRFQALFLFEFRQLNLITRLLTLPQLLFDLYL
SPEAG-SDLVFQYLEENANGVLLIFDGLDQALHPRSSR-------GQAGPEDPSPALDLF
SSLCRGTLLPGCWVLATSRPGKLPNCLPTEA-ATVHMWGFDRPRVEEYVGRFFPDQP-GQ
EAALAELRGSRHLQSLCAVPALCQVTCLCLLR-LLPGSPPGQSAA-LLPTVTQNYVQMLS
TLGPRG------------YLPPEALLELSEVALIGLQTGKVIFSVG-DIRPPTMAFAAAL
SLLTSFCICTGPGHRDTGYAFTHLSLQEFFAALYLMTSPKVDGNALASHITLSSRWVLRT
--KARPGLLD-YLPTFLAGLASRACRPFLSLVAQRDEMWVSARQAVVMQALRKLAARRLT
GPKIVTLCHCVGETQEPELASLMAQSLPCHLSFHNFPLTYADLAALTSILVHRNAPIHLD
FEGCPLEPHCPEALVGCEQVENLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
AQGISHLVQALRLCPQLEEVSFQDNQLKDWAVLNIVEVLPCLPQLRKLDLSRNNVSVSTL
LCLTKVAVECPTVRTLQVREADLIFLLSPPTKTAAELQGAPDLQGNAG-QREEAQSRSLT
LR----LQQCELRFHEAQELIAQLQEGPRLDEVDLSGNQLDNEGCRLMAEAASQLHIARS
LDLSDNGLSVDGVYCVLSAVSMCRTLAE-LHISLLHKTVVFTFAPEQE---EQKGSWDRT
VLPVSLTC--QMPSELPPRPAAIRLTHCGLQA-KHLEQLCRALRGSCHLGQ---L--DFS
GNALGDEGVAQLAQLLPGLGALQSLDLSENGLSLDAVFMLTPCFSTLPWLLHLDISSDSQ
RV---VLRGDRR-GRDRLTG------GSLPDFPAGAQSSA--FHKRCVPRSLCLRQ--CQ
LEPLSLACLCETLKKCPGPLEVKLSCEVLSDQ----SLETLLHHLARLPQLSLLQLSQTR
LS---PKSPLLLADFF----SL-C--PRVQKVDLRSLCHVTLHFRSSEEPEGKCCGRFTG
CGLSQEHVEPLCWLLS-KC-ED------LNELDLSANM----LGDDGLRCLLE---CLPQ
LPVSGSLDLSHNSISLESVLGLVKILPSCPRVQE-ASVNLGSEQSFWIHFSRQEKA-RKT
L--RLSQC-NFGPEHVSRLATGLNQALK--LTALTLTRCCLGLEQLTRLLSLLRWPVGLF
SLRVEESWVGTAGVLALLEV-----CTQASGNITE-ISISETQ----------QQFSLQL
EFPRQ-ENPEAVAL---------------RLAHCDLGTHHNLLVWQLMETCARLQQLSLS
QVNLCDTSS-------LLLQSLLRSLSELKTFRLTSSCVSSEGLAHLISGLSHCHHLEEL
DLSNNPFVE--KDTEALMTVLEGMCWLKRLDLSHLPLGSSALALLTQGLSHMSVLQSLRL
-------------------------------------------------SRNGI-CDVGC
LQLLEALRAASSLKELGLSHNQIGDFGAQHLAAILPALPELRKI----------------
------------------------------------------------------------
-----------------DLSGNGIGPAGGVLLVESLALCKHLEELMLGYNGLGDVTALRL
AQRLPH--HLRVLH---------LPSS--GLSLEGALLLSQALDGRPYVEEISLAVNSLA
TGVPHFH----QGLPLLRQ------IDLVSCEIDNHAAKPLAASLVLCPALEEVLLSWNL
LGDEAAAELARVLPRMSRLKKMDLEKNQITACGAWLLVEGLAQGSGIQVIRLWNNPISPD
VAQHLQSEEPRLDFAFFDKQPQPPRGR-

----------------------MDPDSLQL-GTKSLWSWLVRLLSQAPEWMNAKVKFFLP
NMDLGSRSEALDP---SQRIIQQLRELYAQGPAPWQTFIHCVCMELEVPLELEVPLLSTW
GHG-DGF---------------------------PSPLEAGEDCGPESQLQHGIKRP---
HQSCGSSPRPK-QSRKQQL----ELAKRYLKLLRSSAQQRYGGRIL------GPGQPL-V
FPQAYVPPVLQWSRATAPFSTQEGAL---M-GDPKAEDG--TDVSILDLLNT-RADKGPR

PF05729 // ENSGT00860000133673_1_Domain_0 (301, 475)

VRVLLGKAGMGKTTLAHWLCQKWADGQLDRFQALFLFEFRQLNLITSVLTLPQLLFDLYL
SPEEG-PDAVFEYLEDNANGVLLIFDGLDEALQPY--------------PEALGPALTLF
SDLCRGTLLPGCWVMATSRPGKLPACVPTEA-ATVHMWGFDRPRVEEFVGRFFSDLP-SQ
KAALAELRANRRLRSLCAVPALCRVTCVCLHH-LLPGSSPGQSAA-LLPTMTQTYVQMML
ALRPRG------------YLPANSLMGLCEVALSGLETGKVIFSAR-DIPPATLAFGAAH
GLLISFCICISPGRQETGYAFPYLSLQEFFAALHLMASPEVDQDALARHVTLNSRWVLRT
--KARLGLSD-HLPAFLSGLASCACRHFLSQLAQRDEVWVSAKQAAVAQALRKLATRRLT
GPKVVELCHCVSETQESELAGLVAQSLPYQLQFHNFPLTHADLAAVTNILGHRDAPVHLN
FEGCPLEPSCPEALASCGQVESLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
ARGISHVVQALSLCPQLEEVSFQDNQLKDQEVLSIVKILPRLPHLRKLDLSRNHVSDWTL
LHLTEVAVTCPTVRMLQVTKADLIFLLSPPAETAAELPGAPDLQESAS-SRKEAQSRSLT
LR----LQECQLGVHEVEMLLAQLRKGPHLDEVDLSGNQLEDEGCRLMAEAAPQLHITRK
LDLSDNGLSMAGLYRVLGAASTCRTLAE-LHISLLHKTVVLTFAPEPE---EQAGMQRRA
VFPDSHVP--QTPSELPLRSQRIRLAHCGLQA-KHLELLCKALEGSHHLGH---L--DLS
SNALGDEGAAQLAQLLPGLGPLQSLNLSENGLSPDAGFSLALCFSTVQWVLHLDITGESQ
RI---VLGGAGR-GRDLSAA------GSVPELPAGAEFLG--SGQRCVPRSFCLSE--CQ
LEPLSLTRLCDTLEKCPGPLEVTLSCKGLSDQ----SLETLLHRLPRLPQLSRLRLSQTA
LS---PRSPLILADVF----SL-C--PRVQKVDLQSLCHTTLHFRSSEEQEGGCCGRQPG
CPRTLGHIGELCWLMGTKI-KD------PLEINLSANQ----LGDAGLQCLLE---HLPR
VPISGSLDLSHNRLSQESALCLVETLPSCPRIRE-ASVSAGQQGASGIHFSPPEEA-GED
P--EVTSC-HFRPEHVPRLASGLSQAPQ--LAELTLTQCCLGLEQLTVLLSLVRWPRGLL
SLRVEEPWVGRAGVLTLPEV-----CAQASGNVTK-ISISETQ----------QQLCVQL
EFPRQ-ENPGAVPL---------------RLAHCDLGTHRSLLVRQLMETCARLRQLSLS
QVNLCDASS-------LLLENLLLSVSELKTFRLISSRVSSEGLAHLTSGLSHCPHLEEL
ELSNTQFGE--EDTKVLMGALEGKRRLKRLNLSHLPLGGSSLAVLTQGLSRMILLQSLRL
-------------------------------------------------SSNGI-SDIGC
CHLSKALRAVTSLEELGLSHNQIGDTGAQHLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGPAGGMRLVESLALCTHLEELMLGCNALGDPTALRL
AQALPP--HLRVLH---------LPSS--RLGPEGALSLARALDRCPQVEVISLAENSLA
GGVPHFC----QGLPLLRQ------IDLVSCEIDDQTAKPLAAGFMLCPALEEILLSWNL
LGDEAAAELARVLPRMGRLKRVDLEKNRITACGAWLLAEGLAQGSGIQVIRLWNNLIPTD
MAQRLQSQEPRLDFAFFHNQPPAPRGT-

----------------------MDAESIRL-NNENQWAWLVRLLSKNPEWLSAKLRFFLP
TMDLDCSYEPSNP---EV-IHRQLNRLFAQGMATWKSFICALCLELEIPLDMEIPLLSTW
GPR-EEF---------------------------SKQLGAGEESCPGPQLYHGVKRP---
FQSYGSSPHRK-NSKKQQL----ELAKKYLKLLKTSAQQWHGSVCP------GAWLTP-D
SPQTYIPPVLQWSRATAPLDAQEGAT---L-GDPEAADN--IDVSIQDLFSF-KAHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQALFLFEFRQLNMITQLPTLPQLLFDLYL
RPESE-PDAVFQYLKENAQEVLLIFDGLDEALHA-----------DSVGTDNAGSALTLF
SELCHGNLLPGCWVMTTSRPGKLPSCVPTEA-AMVHMWGFDGLRVEKYVTHFFSDLL-SQ
ELALKEMKTNARLQGMCAIPALCTVTCFCLRR-LLPGSSPGQSAA-LLPTITQLYLQMVE
TFSPSG------------TLLDTSILGFGKVALRGLDTGKVIFSVE-DISPQLMAFGAVH
SLLTSFCIHTRPGHEEIGYAFVHLSLQEFFAALYLMASHTVDKDTLVEYVTLNSHWVLRT
--KGRLGL-SDHLPAFLAGLASHTCHTFLCQLAQQDRAWVDSRQAAVIQVLRKLASRKLT
GPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLD
FDGCPLEPHCPEALIGCGQVENLS-FKSRKCGDAFAEALCRSLPTMGSLKMLGLTGSRIT
AQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLPSLPKLQKLDLSRNSFSRSIL
LSLVKVAITCPTVRKLQVRELDLIFYLSPVTETATQQSGASDVQGKDS-LK-EGQSRSLQ
LR----LQKCQLRICDAEALVELFQK

PF13516 // ENSGT00860000133673_1_Domain_4 (987, 1007)

SPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQK
LDLSDNGLSQTGVTYVLKAMSTCGTLEE-LHISLLSNTVVFTFAQEPR---EQEGSCKGR
APLISFVS--PVTSELSQRSRRIRLTHCGFLA-KHTEQLCEALRASCQT

PF13516 // ENSGT00860000133673_1_Domain_6 (1130, 1152)

HNL--DHLDLS
DNSLGDKGVILLTKLLPGLGPLKSLNLSRNGLSMDAVFSLVLCLSSLQWVFHLDVSLESD
CI---FLRGAGT-SRDA----------LEPKFQTGVQVLE--LSKRYTSRSFCLQE--CQ
LEPTSLTFLCATLEKSPGPLEVQLSCKSLSDD----SLKILLQCLPQLPQLSLLQLRHTV
LS---SRSPFLLADIF----NL-C--PRVRKVTLRSLCHAVLHFDSNEEQEGVCCG-FPG
CSLSQEHMETLCCALS-KC-NA------LSQLDLTDNL----LGDIGLRCLLE---CLPQ
LPISGWLDLSHNSISQEGILYLLETLPSYPHIQE-VSVSLSSEQIFRMCFSKKEGT-GTS
L--RLCEC-SFSPEQVSKLASSLSQAQQ--LTELWLTKCHLDLPQLTMLLNLVNRPTGLL
GLRLEEPWVDSVSLPALMEV-----CAQASGCLTE-LSISELQ----------SKLWLQL
EFPHQEGNSDSMAL---------------RLAHCDLETEHSHLMRQLVETCARLQQLSLS
QVSFNDNDG----TSSKLLQNILLSSCELKSFRLTFSHVNTKSLTHLAFGLGHCHHLEEL
DFSN-SLRE--EDTELLMGALQGTCRLKRLHLSFLPLGASSLALLIQGLSRMTL

PF13516 // ENSGT00860000133673_1_Domain_13 (1795, 1892)

LQDLCL
------------------------------------------------------------
------------------SHNQIGDVGTQCL

ENSGT00860000133673_1_Linker_13_15 (1892, 1901)

AAILPKLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 1980)

LR------------------
------------------------------------------KFDLSRNQIGDMGTQCLA
A----ILPKLPEL-RKFDLSENRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALEL
AQRLPP--QLRVLC---------LPSS--HLGPEGALGLAQALEQCPHIEEVSLAENNLA
GGVPRFS----KRLPLLRQ------IDLEFCKIEDQAARHLAANLTLFPALEKLLLSGNL
LGDEVAAELAQVLPQMGQ

PF13516 // ENSGT00860000133673_1_Domain_22 (2179, 2198)

LKKVNLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPILND
VAQSLQSQEPRL----------------

----------------------MDPIDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPESQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
LHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-ATVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLRHKTVVFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLNQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVE---------------------------
------------------------------------------------------------
----LSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLQSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLHFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

----------------------MDPVSVQL-SSKNLWAWLVRLVSQHPEWLSTKMRFFLP
TMGMGSSDETPDP---DW----QLRQLHAQGQATWQSFIYGLCMELEVPLHLEVPLLSIW
GQD-DGKAR---------------------------PGG--MQGNQHSPMPNRASRP---
HQSCGTSPRRK-QCRKQQL----ELVKKYLQLLKTFTQQHFASQL---------------
---AHVPPILQWSRASTPLDAQEEAG---E-NDLGLDDD--IDVSIQDLFNF-KTHKEP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHWLRQKWASGQLDHFQALFLFEFRHLNLITCFLTLSQLLFDLYL
SPESE-PDAVFQYLEENARQVLLIFDGLDEALHLHSNK-------KPVAADGARSALTLF
SDLCRGTLLPGCWVMATSRPGKLPTCVPTEA-ALVYMWGFDGLRVEKYMSYFFKDLL-SQ
EVALAEMRTNRRLRGMCAVPELCRVACLCLHH-LLPGSPPGQSEA-LLPTVTQLYLQMLL
SLGAHG------------TLSYPSLLGLGKVALEGLDTGKVIFSAE-DIPPSVMAFGAVH
SLLTSFSICTKPGVQETGYAFSHFSLQEFLAALHLMASDRTNTDKLTCHVTLNSHWVLRT
--QTRHGL-SDHLPTFLAGLASHACRPFLSHLAQRDEAWVGTRQAAVVQVLRKLATRKFT
GPKVVELCHCVAETQEPELARLTAQNLPFQLSFHNFPLTHADLATLVSILEHRAMPIQLD
FDGCPLEPNCPEALMGCGQVKNLS-FKSRKCGDAFAEALSRSLPTMGSLQVLGLTGSQVT
ARGIGHLMQVLPLCSQLEEVGFQDNQLKDSEVLKVIKLLSCLPRLQKLDLSRNNFSTSTL
LCLVKAAVTCPAVRKLHVRESDLVFLLSPLPETATERHGSTF------------PSEFLC
SPPHPRLQKCHLRVHDVEALIELLQEGPRLEEVDLSENYLEDEGCRLLAEAAQQLRIT

PF13516 // ENSGT00860000133673_1_Domain_5 (1019, 1034)

RK
LDLSHNELSDSGV

ENSGT00860000133673_1_Linker_5_6 (1034, 1136)

IYVLRAMSMCQTLTE-LRISLLSNTVVLMFAQEPG---GQEGSGERA
AMRNSLAP--PVASEPPLGPRRIRLAHCGFRA-KHIEKLCKALGAGCLLSS---G

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDLS
DNALSDEGLTLLAQRLPGLGPLQSLNLSKNGLTLNAVFTLAQSMSALKWLFHLDISLESE
LV---FLRGEKATLSSLH------------------------ISCSDPCPHTCLRE--CQ
LEPSSLARLCAALEDCPGPLKVQLSCKTLSDE----GLETLLRSLPRLPQLSLLQLSHTD
LS---LRSPLLLADIF----GL-C--PRIRKVALSSLHHVALHFGSSKEQNGVCCG-FTG
CSLRQEHMKPLCHMLS-QC-EA------

PF13516 // ENSGT00860000133673_1_Domain_9 (1409, 1428)

LRQLDLTDNL----LGDDGLRYMLE---YLPQ
LPIAGWLDLSHNRISLEGTLHLLETLPFCPHIRQ-ALVNLGFKQHFRIRFSKQDEA-GIT
L--RLSEC-SFEPEHLPRLAAGLSQAQQ--LMELSLTQCHLDLQQLTVLLSLVRRQTGLL
GLRVQEPWVGQVGVPALLEV-----CTHALGLIAE-LSISETQ----------QQLWIQL
EFPHHEENPEAVAL---------------RLAHCDLGTHHSLLVRQLMVTCNRLRQLSLS
QMNLCNDDDTLIS---------------------------ISGPGHACLILASC--LVPS
SFSHNQCDA--ENTELLVQALQGTCGLRRLHFSHFPLGGSTLAMLIQGLSHMTVLQCLCS
------------------------------------------------------------
---------GPL

PF13516 // ENSGT00860000133673_1_Domain_14 (1873, 1892)

LFSLSLSHTQIGDTGAEHLAAILPEFPELRKIDLCVQA----------
--------------------------------------GGLWGN-------LT-------
------------VTLSCSLSGNSIGLAGGVQLAKSLTLCRRLEEVMLGHNVLGDPTALEL
AQGLPP--HLRVLRLLLPCPFHSLPSS--HLGPKGALRLVQALEWCPNMEEIILAGNKLA
GGVPHFC----KGFRLLRQ------IDMVSCEIDDQAAKRLVASLILCPALEEILLSWNL
LGDEAAAELAQVLPQMIQLKRVDLEKNRISAQGAWLLAQGLARGSCIQVIRLWNNPIPPS
AAQCLQSQEPRLDFAFFDKHS-------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------LSSQLTGDKESQSESQLHQGLKRP---
HQNYGNSPRRK-QSRKQQQ----GLAKRYLQQLRTYTEQCYGGRSP------GSGLFP-A
SQQAYVPPILQWSRTTTPSHTQEGVA---V-GALKAEDG--TNISILDLFST-KTNKDP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

K
VTVLLGEAGMGKTTLAHCLCQQWADGQLKCFQALFFFEFRQLSLIPNSMTLLQLLFDLSL
SPEDD-PQAIFQYLEMNAHGVLLIFDGLDEALYP-------------TDPKDAGSPLDLF
SGLCRGTLLPGCWVLATSRPGKLPTCLPTEA-AMAHLWGFDQPRVEAYVRHFFSDQT-YQ
EAALVEVRGSGSLLNMCAVPALCQVTCLCLQH-LLPDSSPGQAAA-LLPTVTQSFMQMVL
TLSPRRDRG---------DCTTDFLLSLSEVALWGLENSKVIFSAG-DIHPSTMAFGATH
SLLASFRVCTGPGHLETGYAFTHLSLQEFFAALYLMVSPKVDTDKLACHVTLNSRWLLRT
NA--KSDL-SGHLTTFLAGLASSACHPFLLFLAQQDKAWVDARQAVVIQTLKKLATHKLT
GPKVIELCHCVSETQDPKLASFIAQNLPSLLHFRNFLLTSTDLAALTNILGHRDAPIHLD
FEGCTLGPYVPETLAGCEQVESLS-FKSRKCGDAFAEALARTLPTMKNLKQLGLTGSQIT
AQGIHQLVQALCLCPQLEELHFQDNQLKDQEILHIVEVLPDLPQLRKLDLSRNSIMVSTL
LRLTEVAVTSPMVTILQVGXXXXXXXXXXXXXXXXXXXXGADLQGNAN-QKGEALSRRLT
LR----LQECELRVHSADILIAQLRRCPHLIEVDLSGNQLEDEGCCLMAEAASQLHIIKK
LNLSDXXXXXXXXXXXXXXXXXXX-XXXXXXXXLLQKTAIFMFSPELE---EQEGTQKXX
XXXXXXXX--XXXXXXXXXXXXXXLTRCGLQA-KHLEQLCKALRGSSHLSDLSGL--DFS
DNALRDEGVTQLAQLLPGLGPLHSLNLSQNNLSLDALFILAQCFSVLQWVLLLDISFESQ
QV---ILRSDRG-GRDPQPA------EFGPDFQAGAKFLG--SGLHCIPKSFCLRE--CH
LEPQSLQRLCETLEQCAVPLEVMLSCEHLNEK----TLNTLLYHLPRIPSLNLLQLSLAR
KL--PLRSPFLLADLF----SV-C--SKIQKVELRSLCHMSLHLKTSEEQEGRYCGRFIG
CDLGQEHVKTLCRLLN-KC-DH------LSQLXXXXXXXXXXXXXXXXXXXXX---XXXX
----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXLGPEQSFWIHFSRKEEA-RKT
L--RLSKC-SFGLENMPRLATGLSQALQ--LTELTLTQCDLAQEQLASLLNLVRKPAGQL
TLRVKEPWVGRTRMKALLEV-----CTQASGNITEIXXXXXXX----------XX-XXXX
XXXXXXXXXXXXXX---------------XLAHCDLETYHNLPARELRETCAKLQQLSLS
QLSLCDDSS-------LMLQSLLLSLSELKKFRLTSSCVSSQGLAHLASGLSHCHHLEEL
DFSSNEFCK--EDTTVLLGALESKQRMKRLDLSYLPLGDSNLAVLTRGLNHMTLLQSLRX
XXXXXXXXXXXXXXXXXXX-----------------------------------------
---------X---------XX-----XXXXXXXXXXX---XXXX----------------
------------------------------------------------------XXXXXX
-XXXXXX-----XXXXXXLSNNSFGPMGGERLAESLALCR

PF00560 // ENSGT00860000133673_1_Domain_19 (2021, 2053)

HLEELRLGHNVLGDPTALRL
ARELPP--HLRVLL---------LQAC--HLSPTGLLSLGQALDGYLHVEELSLAENSLA
GGVLSFC----RGLPLLRQ------IDLVACEIDDQTAKPLAASFLLCPALEEILLSWNQ
LGDMAAAELALVLPQMGRLKRMDLEKNQITAHGAQLLAAGLAQAPGIQVICLWGNSISHE
KVQHLQRQNPRLNFAFFDSKSQTSGDT-

----------------------MDPISIQL-GTRNLWSWLVSLLSKDPKWLSDKMSFFFP
NMDLGSQNEVSDP---EQWVILQLRALHAQGLNTWQSFIHSVCMELEVPLELEVPLLSTW
GSE-DGF---------------------------PSQLGDDGGSQPECQLHHGLKRP---
HQSYGSSPCRK-QSKKQQL----ELARRYLQLLRTSAQQRYGDRLS------GSGQPDLA
SQQPYIPPILQWARATVPLDAQRGAG---M-GDIKAEDG--TDVNIWDLFNP-RTKKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGTAGMGKTTLAHRLCQQWAEGQLDHFQALFLFEFRQLNLLTSFLTLPQLLFDLYL
RPESG-PDAVFQYLTENAGRVLLVFDGLDEALQPCSGG-------DPGAPEGLGPALTLF
SGLCAGTLLPGCWVMATSRPGKLPPCLPAEA-AVVQMWGFDSPRVEEYASRFFSAQP-SR
EEALAELRGNGRLRRMCAVPALCRVACLCLRH-LLPDSAPGQSAA-LLPTVTQLYVQMVL
ALGPPG------------RLPTAPLLGLGEVALRGLEAGKAVFYAG-DIPPSAMAFGAAH
SLLTSFSVYTGPGHLQTGYAFAHLSLQEFFAALYLMASPEVDKDTLAHRVTLNSRWVLRT
--KARVGL-SDHLPTFLAGLASRACLPFLGWLAERDGAWVGARQAAVVQALRKLATRKLT
GPKVVELCRCVDETQKPELARLAAQSLPCQLSFHNFPLTCADLTSLTGILERRDAPIHLD
FEGCPLEPRCPEALEGCGQVENLS-FKSRKCGDAFAEALSRSLPTMGRLQKLGLAGSKIT
AQGIRHLVKALPFCPQLEEVSFQDNQLKDQEVLHIVEVLPCL

PF13516 // ENSGT00860000133673_1_Domain_3 (883, 896)

PRLRRLDLSGNNI

ENSGT00860000133673_1_Linker_3_4 (896, 989)

SVSTL
LSLAKVAVTCPTITMLQVREADLIFLLSPCAETAGELQRAPDLQEDDS-QRKGAQSRSLT
LR----LQQCQLQVDHVEALVALLLEGP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1007)

RLEEVDLSGNHLEDEGCRLMAEAALRLHITRK
LDLSDNGLSVAGLGCMLPTVSTCRTLAE-LHVSLLHKAVVLTFAQKTE---EQEGPQKSA
AFLDSLVS--QVPSELPLSSCKIRLTHCGFQA-KQLQQLCKALEGSCHLGQLRQL

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAALLAQLLPGLGALQSLDLSGNGCSLGAVLALARCFSTLPWLLRLDVSLESQ
RI---LLTGARR-GRDTQAG------GRLPEIPAGAEFSG--FGQRCAPRSFCLRE--CQ
LEPLSLHQLCDTLEQCPGPLEVQLSCAVLSDQ----SLETLLQCLPRLPHLSLLQLSETG
LP---ARSPFLLADAF----AL-C--PWVQKVDLRSLRHATLHFTSSREQRGVCCG-FTG
CGLGQEHVESLCWLLS-KC-ED------LVGEGEGEETWDAHLGLHGGPAP-------PH
PEPHVPSSLSHNGISQEGALLLVEALPACARARG-ASASLGSAQSFRIHFSKQEEA-GKT
L--RLSEC-SFGPEHVPRLATGLSQSLQ--LSELTLTRCCLGREQLMVLLSLVRRPAGQL
CLRYGVPPARERS---------------TAPGITA-MAISRTQ---------NPAICPRD
LARRSETAPSLSPS---------------RLAHCDLGTHHSLLVRQLMEACARLRQLSLS
QVNLCDDGD-A--SV-LLLQSLLPSLSELKTFRLTSSCVSTKGLTQLASGLS

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1757)

HCHHLEEL
DLSNNQFCE--EGTMALVRALDGKCRLKRLNLSHLPLGGSTLAMLTRGLSHMTLLQSLRL
-------------------------------------------------SRNSI-GDLGC
CHLSEALRTA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELGLSHNQIGDAGAQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

AAILPGLPG

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSANDIGPKGGVQLAESLTLCRHLEELMLGRNALGDPTALGL
AQELPQ--HLRVLH---------LPSS--HLGPEGALSLGQALDGRPHVEEISLAENSLA
EGVPHFC----KGLPIHPQSIPFPIRSLVSCKIDNQTAKLLAASFLLCPALEVILLSWNL
LGDEAAAELARVLPQM

PF13516 // ENSGT00860000133673_1_Domain_22 (2177, 2198)

SRLKRVDLEKNQITARGARLLAEGLAQGSGVQVIRLWSNPIPAA
VAQSLQGQEPRLDFAFFDKSPPNT----

----------------------MDPVSLQL-GTRNLHGWLVRLLSRNLEWLDAKVKLFLP
NVDLGSEYQALDP---AQRVILHLQKLHTQGPTTWKSFIQCVCMELDVPMDMEVLLMSMW
GHE-DGF---------------------------PSLLEIDKESRSDSQLHPGLKRT---
YQSCGSSPRRK-QLRKQQQ----ELAKKYLQLLRTSVQQRYGDRTP------GLGQPL-A
FHQVYVPSILHWSRASAPFHTQAGAT---T-G---AQDG--TNVNIRDLFST-KASKGPR
VTVLLGKAGMGKTTLAHS------------------------------------------
----------------------------------PSDK-------ETANPEDPASALTLF
SRLCRGTLLPGCWVMATSRPGKLPACLPTEV-ATVHMWGFDGPQVEEDGNHFFSDQ----
EAALAELRVDRRLWSMCAVPALCRVACLCLHH-LLPGRSPGQAAA-LLPTMTQNYVQMLL
AL-----------------------------------EGKVIFSTG-DIPASTLAFGDAL
GLLTSFCVCTGPRHRDKGYAFSHLSLQEFFAALHLMTRPQVDREALSQHVTLHSRWVQRT
--KARLGLSD-HLPTFLAGLASHACRSFLSLLAQREEEWVAARQEIVLQALKKLATRRLT
GPKIVELCHCVGETQEPELANFMAHSLPQQLPFHNFLLTYADMASLTNILGHRDGPIHLD
FEGCPLEPRCPETLAGCGQVENLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
ARGISHLVQALPFCPQLEEVSFQDNQLKDKEVLNIVKVLSCLPRLQKLDLSRNNVSVSTL
LSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETAAELQGDPDLQGNTN-QRKEAQRRSLA
LR----LQKCQLGVHDVEVLIAQLQEGPQLDEVDLSGNQLKDEGCRLMAEAAPRLHITKK
LDLSDNGLSVAGVLSVLSVVSTCQTLAE-LHISLLHKTVVFTFAPELE---EQEGIQKRA
TFPDSLTF--QMPSEPSLRSLRISLSLHLSLSLSLSSPSPISVXGVCRLGP---FEEGLS
GTGLGDEGVALLARLLPGLGSLQSLNLSENCLSLEGVFSLIQCFSTLQWLLHLEFSSASQ
HI---ILRGDKR-GRDLLAP------GSLPEFRAGAR-LG--FGQRHVPRSFCLKD--CQ
LEPLSLSHLCKSLEKCPGPLEVQLSCEVLSDQ----SLETLLHHLPQLPQLSLLQLSQTQ
LP---PRSPLLLADLF----SL-C--PQVQKVDLRSLRHLTLHLRSSEEQEDRCCWRFTD
CGLRQEHVEPLCCLLS-KC-ED------LNQLDLSANL----LGDDGLRCLLE---CLPK
VPISGSLNLSCNSMSQESVLCLVEALPSCPRVRE-ASVNLGSKQSFWIHFSRQEEA-GKT
L--RLSEC-HFKPEHMPRLAASLNQALQ--LAELTLTWCFPGLEQLIVLLGLLTWPTGVL
TLRYRLPVTLRAGLPKLLEV-----CARASGNITE-ISISETQ----------QQLCIQL
EFPHQ-ENPEAVAL---------------RLAHCDLGTHQNLLARQLMETCARLRQLSLS
QVNLCDASS-------LLLQSLLLSLSELKNFRLTYSCVSSKGLAHLTSGLSHCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1749)

HLEEL
DLSNNQLGD--EGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSLRL
-------------------------------------------------SRSNI-DDVGC
CHLSKALRAATSLEELSLSHNQIGNTGAQDLAAVLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGPAGGARLAESLTLCRHLEELMLGCNALEDCTALGL
ARGLPQ--HLRVLH---------LPSS--HLSPEGVLSLGQALDGCPHVEEISLAENSLA
GGVLRFH----QGLPVLRQ------LDLVSCEIDNQTAKPLTASFVLCPALEKIMLSWNL
LGDEAAAELARVLPQMGRLKRVDLEKNRITAYGAWLLVEGLAQGSGIQVIRLWNNPIPPD
MAQHLQNQEPRLDFAFFDNQPQVIPRGT

----------------------MDPISLQL-GTKNLWGWLVRQLSKDPEWLSAKVKFFLP
NMDLGSRNEDPEP---TERVILQLSKLRTQGQATWQAFIHCVCMELDVPLDLEVPLLSTW
GHG-DGFL----------------------------QLEAGEESQPDPQLQPGLKRP---
HQSCGSSPRPK-QCKKQQQXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXX--
--XXXXXXXXXXXXXXXXXXXXXXXX---X-XXXXXXXX--XXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXX--------------XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-XXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXX-------------XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXFKSRKCGDAFAEALSRSLPTMENLKKLGLAGSKIT
ARGISHLVQTLPLCPQLEEVSFQDNQLKDREVLSIIEILPYLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 900)

RLRKLDLSRNNISVSAL
LSLTKVAVTCPTIRMLQVREADLIFFLVPPAEAAAELQXXXXXXXXXXXXXXXXXXXXXX
XX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXLSGNQLEDEGCQLMAEAASQLHITRK
LDLSDNGLSAAGVHRVLSAVSTCRTLAE-LHISLLHKTVVLTFAPEPE---KQEAIRERA
AFPDSIML--QMPPEPPLRSPRIRLTHCGLQT-QHLEQLCKALRGSCLLGH-----IDLS
GNALGDEGVALLAQLLPGLGALQSLNLSENGLSPDAVFSLTLCFSTLQWVLHMDFXXXXX
XX----XXXXXXXXXDLLAG------GSLPEFQAGAQFLG--FGQRHISRSFCLKE--CQ
LEPLSLSCLCETLEKCPEPLKVXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXLSQTR
LS---PESPLLLANLF----SQ-C--PHVQKVDLRSLNHTTLHFRSREEQEGGCCGRFTG
CSLSQEHMERLCCLLS-KC-ED-----

PF00560 // ENSGT00860000133673_1_Domain_9 (1408, 1438)

-LRQLDLSGNL----LGDDGLRCLLE---CLPQ
VPISGLLDLSHNNISQEGALCLVDALPSCQRVRE-ASVNLGSKQSFWIHLSQQEEA-RKT
L--RLSEC-SFGPEHVPRLAAG-SQALQ--LTEITLTQCCLGLEQLTVLLSLLKWPAGLL
NLRVKEPWVGXXXXXXXXXX-----XXXXXXX-XXXXXISETQ----------QQLCIQL
EFPQQ-ENPEAMAL---------------RLAQCDLGTHHSLLVRQLMKTCAKLQQLSLS
QVNLCDASS-------LVLQSLLLALSELKXXXLTSSCVSAKGLAHLTSGLSHCQ

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1760)

HLEEL
DLSNNQFDE--DGTKVLMGALEDKCWLKRLXXXXXXXXXXXXXXXXXXXXXX--------
-----------------------------------------XXXXXXXLSQSSI-SDVGC
CHLFKALRATT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1894)

RLEELGLSHNQIGDAGAQQLAALLPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGLAGGARLVESLALCRHLEDLMLGCNDLGDPTALGL
AQGLPR--HLRVLXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXX--XX
XXXXXXX----XXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLSWNL
LGDEAAAELARVLPRMDRLKRVDLEKNRITTRGAWLLAEGLAQGSGIQVI----------
----------------------------

----------------------MDPVDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPESQLHQGLKRP---
HQSCGSSPRRK-QFRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDIQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPTGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSAQP-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
TLSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLLFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHITRK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLQHKTVVFMFAQEPE---EQEGPQERV
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---LHLDFS
GNALGDEGATQLAQLLPGLGALQSLNLSENGLSLDAVLRLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWTT------GSSPDFPAGAKFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVEKVDLRSLHHATLHFRSSEEQEGVCCG-FTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWANRAGILSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLTHLASGLGHCHHLEEL
DLSNNQFDE--EGTKALMTALEGKWRLKRLDLGHLLLNSSTLTLLTHGLSHMTRLQSLRL
-------------------------------------------------KRNSI-GDVGC
CHLSEALRAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1895)

SLEELDLSHNQIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLVLCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFRRCPALEVILLSWNL
LGEEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQSQAPWGT-

-------------------------MDTIS-LPESLWSQLVEMLSKDPQWLIEKAQSLLP
AVDLQSLRSQAKNLAATQVVPGLLRLLWTHNLTTWRMFIQTLCMELTLPLELETTLLSVW
GQGNNLLIV---------------------SGGPGQKRDEGDENHVH--------QRPHL
GGVS---PQRK-RFRCQQL----EPARNYQRLLKASVLQRYSSEAAIPP---GPWRDN-T
SGQVYVDLVIRRNKPAWLRERLERSRDE-ASETEDG-----ADVGVSGMFEA-GNGPRT

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 473)

R
VIVLLGKPGTGKTTLMRWICQKWARGELGQFQSVFLFEFRQLNLVGENLTLQQLLFDLFQ
PPRAQ-PQLIFQDLEENASRVLLIFDGLDEFLGPWPEGSSQPREKPAPNPSAPASVLDLF
SGLCCGTLLPGCCVMVTSRPGRLPDFLLNTVTASYEVWGFDWPRVKEFTSHFFLAPE-ER
CQALRVLEGDRKLQIMCSVPAVCRVICICLAHLP-P----DQPSTPLPPRVTQLYVQLFR
IILGQQPSPKHG--GASLGKPQPALLGLCKLALKGLEERKVVFSAE-DVSEPVRTLALRH
HLLISFEVRAGPRRQETVFAFPHLGLQEFCAALHFLVSPSVDRGSLKKKFPLKSKWSVRT
--ESKMGL-LDHFHIFLSGLSSPACRGFLAQLARRKEAWVQDKQLVVLEFLLKLATTSLT
GPKVMELCHCVGETQDPELAERVGRHLHHKYGFRNFRLTHSDLMALALLVDCGTTPIHLD
FAGCPVEPDCLESLAKCRNIGSLS-FRSRKCGDAFAEALARSLPGMESLKKVGLIGSKIT
AQGVDHLMQAFTNCLQLEEINLQDNKLRDLEVLKITEIFSGVKKLQKIEVGKH-VCLPTM
SLLSREGRVCTLYRLLQAKQKTISRHILEGTAENGELQGSLDLKRNEDKNETAPQTKKLT
LR----LQQCKLGVQHAEAIAGLLRESSCLEEVDLSGNHLEDNGCRELMKVLPYVTITRK
FNISDNGLTTEGVCCLLNTVTACSNVVE-VEACLQLKTTILTFAGSYEAELALPSRAGTL
VA--AALH--LPFPLPISKGKVYHLMDCERMSLHSLTSCCRVL-DRERHSF---VHSVLS
DNSLGDKGIQMLVLLLPGLRTLKTLNLSGNNGSLEIAFYLAQAFSTLEQIAGMDIGLGSQ
QSILVTLRGRTS---ILPT-------PPSPTLPPSP--A---FLFNCSPGSTNLRE--CA
LEPASMQRLCQALEKCSGSMDVRFSCNALSDQ----SIEVLLHYLPRLQSLQHLHLIECG
SP---PRGFPLSSSPTPFSVALTC--SLY-SPPPSQPHRTYVHISHLFI---YINVCLPF
DCLGIASLMT---LSD-NDSHWLLVKAKVNSLCLSVLR----LTDSNVS-LLD---LKHF
LSLQRVM---DEWQGCHGEQWLMTYLQAPAFCPP-VMLYVCHVHQPILEPHFSSFP-AHL
IFIMGAEG-AWRPPLLKRY-LMSAKVNSLCLSVLRLTDSNVSLLDLKHFLRAVRKPSGML
RISVEEQWVLKEDIATLLEM-----SIQAAGSLTE-ITILKFQ----------ALLRVGE
EFPQYTENPEPEAA---------------RVAQFGPESGQTSLIRRIIEKCTRLRELNWS
HVVLNDDAS-------QILKSVLPSLSILKTFRLTSSPIFPRGIEHLAAGLSCCHGLQEL
EVSGLLFQQ--KDTPTVVLD-KSSSGSLPHSLSNLKLDDPEVQILTQGLHQMSLLQRLTL
-------------------------------------------------SNCGV-SRDGC
FHLSDALRKTSNLEDLNLSLNEIDSAGVQHLAAVLPGMLHLRRL----------------
------------------------------------------------------------
-----------------DLSENCLGPSGGVELARALVFCRKMEEYRLGKNAMEDITAVEL
SKTLPS--YLKILN---------LQSN--NIGPEGLASLALTLARCRQVEEISLAENTFG
DVI-PLLFSKLSGLPKLRK------IDLKCCGIRDQEAKSLALSFGSCPAMEEILLSWNC
LGDEGATELAQVLPQMTKLRKLDLESNQITVQGARQLVEGLAQGPGIQVVRLWKNRIPKD
VASQLQEQDSRLDFSSFPQQ--------

----------------------MDLTGFQL-GHKNLWSSLIRLLSDQPEWLNAKVKFFLP
NTDLGPSDETADP---TEWVILQLKTLHAQGLAIWERFIYCVCMELXXXXXXXXXXXXXX
XX----------------------------XXXIPGQLGASEGGCSESQLHHGLKRP---
HQSCGSSPRRK-QCKKQQL----ELARRYLQLLRTFTQQRYGGKTP------SPGQPL--
--SYYVTPILQRSRVTVPLDTQEEAV---T-A----ED------GIWDLFST-KMKKGS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 470)

R
VTVVLGKAGMGKTTLAHQLCQKWADGQLDRFQALFFFEFRQLNLVTGLLTLPQLLFGLYL
SPESG-ADAVFQYLQDNAHSVLLIFDGLDEALNP-------------GDPVTPRSAFALF
SDLCSGTLLPGCXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXX------------XXX--XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXFFSQLAQQDEAWVGARQDAVVEALRKLVT-KFR
GPKVIKLCHYVVETQEPGLAQLAAQSLDCPLSFHNFPLMYTDLSVLANILGYRDTPIHLD
FDGCPLEPHCPEALVGCGQVENLS-FKSRKCGDAFAESLSRSLPTMRNLQKLGLAGSKIT
AKGISHVVKALSLCPQLEEVSLQNNQLKDQEVVNIVKVLSSLP

PF00560 // ENSGT00860000133673_1_Domain_3 (884, 906)

RLQKLDLSDNDVSTPTL
LSLAKVAVTHPTFRALQAXXXXXXXXXXXXXXXXXXXXXAPDLEGNAS-QTEEAQTRSLT
LR----LHRCQLRVHDIEVLINLLRNGPCLEEIXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXLSDNGLSASGVHCVLSAVITCWTLAE-LHISLLHKTVVLTFAQELEEKDTQRXXXXXX
XX----XX--XXXXXXXXXXXXXXLTLCGFQA-KHLEQICTALRGSCHH-----LHLDLS
GNAMGDEGAILLARLLPGLGTLQSLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLQSQ
RFH--LTHDRRH-XXXXXXX------XXXXXXXXXXXXXX---XXXXXXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXLSCEFLSDR----SLETLLQCFAQLPQLSLLQLSQTK
LS---PESPLLLARIF----GL-C--QRVQTVELRSLHHASLHFKSSEEEEGMHCSRFIG
CSLLQEHIEPLCWSLS-KC-KD-----

PF00560 // ENSGT00860000133673_1_Domain_9 (1408, 1438)

-LHQLDLSNNQ----LADDGLKSLLE---CLPM
MAISGSLNMSHNSMSLESVLYLVENFPSCAGACE-ALVNLGPKQSFWIHFSRQEEA-GKT
V--RLSQC-SSLPEHVPRLATGLSQAHQ--LTELMLTRCGLGLEQLTILLRLVRRPSGLL
RLSVEEPWVGRVGIVELLRA-----IAEVSGNVTE-ISISVTQ----------QRFCVQL
EFPRQEENPEAVVL---------------RLAHCDLGTHHSLLDRQLMETCIRLRQLSLS
EVNLSDSSS-------LLLHSLLLFLSELKKFRLTSSYVSTQGLTYLASDLSHCHGLEEL
DFSGNQVYE------PLMGTPEEKC--LKLDFSHLPLGGWFLNQLTQGLRHMTFLQSLIL
-------------------------------------------------SRNGI-DDVSC
HHLSEALRDAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

SLEELALSYNQIGDNGAQLLAAVLPG

ENSGT00860000133673_1_Linker_14_15 (1898, 1900)

LP

PF00560 // ENSGT00860000133673_1_Domain_15 (1900, 2019)

KLRKL----------------
------------------------------------------------------------
-----------------DLSANGISPAGGVQLAESLIL

ENSGT00860000133673_1_Linker_15_19 (2019, 2021)

CR

PF00560 // ENSGT00860000133673_1_Domain_19 (2021, 2053)

HLEELKLGYNALQDPTAQVL
ARRLPP--QLRVLC---------MPSI--HMGPAGALSLGQALDGCPQVIEISLAENRLT
RGLPQFS----EGLPLLRQ------IDLISCEIDDQTAKPLAASLLLCPALEEILLSWNF
LGDEAAAELAQVLPRMGRLKKVDLEKNRITSHGAQHLAEGLAQGPGIQVIRLWNNPIPHE
VAQCLQNQEPRLHFAFFEDKPQAPQST-

----------------------MDPVDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVTLQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGTEGKSLPKSQLHQGLKRP---
HQSCGSSPRRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKSGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTPSQLLFDLYL
SPELD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNHFFSAQP-SR
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCIRTGPGHQQTGYAFTHVSLQEFLAALHLMASPKVDKDTLTQHVTLHSRWVQRT
--KARLNL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRMLQARKADLIFLLSPPAETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LRISLQHKTVVFMFAQEPQ---EQEGPQERA
AFLDSLTL--QMRSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLAHLCATLRECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGLLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-RKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LMELTLTQCCLDQEQVAILLSLVGRPAGLF
ILRVQEPWADRASILSLLEV-----CAQASGSITE-ISISKAQ----------QQLCVQL
EFPRREENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-A--SS-RLLQNLLLSLSELKTFRLTSSCVSTEGLTHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1791)

MRALEGKWMLKRLDLSHLLLNSSALTLLTHGLS

PF13516 // ENSGT00860000133673_1_Domain_13 (1791, 1860)

HMTCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPRLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLVLCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTIKLLTSSFTRCPALEVILLSWNL
LGDEAAAELAQVLPQMGRLKRVDLEKNQITAFGAWLLAEGLAQGSSIQVIRLWNNPIPCD
TAQRLKSQEPRLDFAFFDNQSQAPWGT-

----------------------------QL-GTRNLWSWLMRLLSTQPEWLSTKMKFFLP
NVELDSRDEPPNP---EQRVISQLQMLHAQGQATWKSFIHCVCMELEVPLDLEVPLLSTW
GQE-DGK---------------------------------GGHEGSLPLLSPGLKRP---
HQGCGSSPRRK-HCRKQQL----ELTRKYLQLLRTSAQRHCGDGVP------KPGPTF-G
AHQPYVPPILQWSRATAPLDPREGAV---L-GDPKTEDS--TDVSLQDLFNF-KAPKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKSTLARRLCQKWAEGQLDHFQALFLFEFRQLNLITRFLTLPQLLFDLYL
SPEAG-PEAVFQYLKENANRVLLIFDGLDE---------------DTLGPNGSGPALTLF
SALCRGTLLPGCWVMVTSRPGKLPACLPTEA-AMVHMWGFDGLRVEEYVSRFFSEQP-AQ
EVALAELQGNGHLQSLCAVPALCQVTCLCLRH-LLSGNAPGQSGA-LLPTVTQLYMQMVL
TLSPPG------------SLPAKSLLGLGEVALRGLEVGKVIFSAG-DFPPAIMAFGATH
SLLTSFCIHTDSGHREIGYAFAHLTLQEFFAALHLMASPSVDKDILTSHVTLNSHWVLRT
--RTRLNL-SDHLPTFLAGLASPTCRPFLRHLAQRNEAWVGARQAAVLQVLRKLASRKLT
GPKVVELCHYVAETQESELASLTAQSLPYQLPFHNFPLTYRDLSALTSILEHREDPIHLD
FEGCPLEPHCPEALAGCGQVETLS-FKSRKCGDAFAEALSRSLPTMGNLKTLGLTGSKIT
AQGVSLLVQALPLCLQLEEVRFQDNQLKDREVLSIAEVLPRLPRLRKLDLSRSSFSTSTV
LSLVKVAVLCPTVRVLQVREPLLLAQ-DPRATKACT----P-HSCSQR-WRGP-SSLLRP
SVLYPRLQKCQLRVHNAEALIALLLEGPP

PF13516 // ENSGT00860000133673_1_Domain_4 (990, 1009)

LEEVDLSGNQLEDEGCRLLAEAASRLHIARK
LDLSDSGLSVDGVSCVLSALRTCQALET-LHISLLHRTAVLTFTRELE---EQRGTQESP
CLVR---------VTHRLRSPRCRLTHCGFQT-KHLEQLCRALGGSG

PF13516 // ENSGT00860000133673_1_Domain_6 (1128, 1153)

HLGH-----LDFS
GNSLGDEGVTLLAQLLPGLGPLQSLNLSENGVSLSAVCCLSQCMSALQWAAHLDVSPQCL
GCH--LLRGHLLTERGY----------FSPKYTTMHKRGGVWRERRRAFAGACLKE--CQ
LEPLSLTSLCATLEQCPGPLEVQLSCETLSDQ----SLDTLLQCLPRLPQLRLLQLSPTG
LS---PRSPLLLADVF----SL-C--PRVQKVDLRSLTHATLHFRPSEDKEGVSCG-FRS
CSLSLEHVEPLCCLLS-KC-DN------LSQLHLAENL----LGDDGLRCLLE---HLPQ
VPISGSLDLSLNGISREGVWQLLETLPSRPRVRE-ASVNLGSAQDFWIHFSKRGETPQTT
L--RLSEC-SFGPEHVPRLATSLSQALQ--LTEITLTRCGLGLEQLALLLSLTRPPAGRL
CLRVEEPWVGRAGVPALLEA-----CAQASGNVTE-ISISETQ----------QRLCVQL
DFPRQEENPEAVAF---------------RLAHCDLGTHRSLLVTRLMETCARLRLLSLS
QVNLPDTSDAG--C------------------LLTSSCVSPESLVHLAAGLVHCHHLEEL
DFSNTWLSE--EGTRTLMGALQGKCRLRRLDLSQLLLGGSTLAMLTQGLSHM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1892)

TLLQSLRL
-------------------------------------------------SHNAI-GDA--
--------------------------GAGHLAAILPKLPELRKIEGPAVLTPAPRRH---
------QPPVPASTE---------------ISLPPPSVSGQWDG-------PPPAVGCPC
-VGCGRR-----VGIRWLLSANGIGLAGGAQLAKSLALCRKLEELGLGFNALGDPTALGL
AEGLPQ--HLRVLH---------LPSS--HLGPEGALSLGRALDGCPHVKEISLAENSLA
KGVPHFC----KGLPQLQR------IDLASCDIDNQAAKGLAASFTLCPALEEILLSWNL
LGDEAAAELAQVLPRMGRLKRVDLEKNRITACGAWLLAEGLAQGSAIQVIRLWNNPIPPG
VAQRLQSQEPRLDFAFFDKQ--------

------------------------------------------------------------
-----------------------------PGGGWWWM-VTAISSSA-------HGSACSW
CVIRAQY-P-------------------------ACAAQSSQLTLPFPSLFPGLKRP---
CQSCESSPRQK-HCRKHRL----ELAQNYLKLLRTSALTHYGDGLS------GPGK----
---IYVPPILQWSRATVSLDTQGGAI---T-GDPKIEDG--SDVSIQDLFNF-KTPKSS

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLARWLSHKWADGHLDNFQALFLFEFRQLNLITHFLTLPQLLFDLYL
RPESG-PDVVFQYLEENANQVLLIFDGLDEALYPCSSM-------ETVGPNDTGLALTLF
SSLCRGTLLPGCWVMATSRPGKLPACLPTEA-AMVHMWGFDQLRVEEYVNHYFSDQP-SQ
EVALTELLANRHLRSMCVVPALCRLACLCLHH-LLPASLPDQSVASLLPTMTQLYMQMLL
TCSP---------------LPAKLLVGLGEVALSGLETGKVIFYDS-DIPPPVMAFGATH
CLLTSFCVRTGPGHQETGYAFVHFSLQEFFAAIYLMTSPIVDKDILARHVILNSPWVLRT
--KARLGL-TDHLPTFLAGLASYTCRPFLSQVAQQDETWVGTRQAAVVQLLRKLATRKLK
GPKVVQLCHCVAETQEPELAGLTAQSLPYQLPFHNFPLTYADLAALTSVLEHRATPIQLE
FEGCPLEPHCPEALVGCTQVETLR-AALSPLRWD---------PVRQLCVSTGLSGS---
-------SWSLLVTEPPFKYSLQDNQLKDQEVLSVVEIMPSLPRLQKLDLSHSSFSISSL
FYLVKVAVTCPTVQTLQVRLTTFSRYA-------------------------EGQSSKSQ
SE----LQKCQLRVHHVEVLVELLREVP

PF13516 // ENSGT00860000133673_1_Domain_4 (989, 1009)

RLEEVDLSGNQLEDEGCRVLAEAASRLHITGK
LDLSDNHLSVDGVSSVLRAVNSCESLAE-LHISLLQKTVVLMFAQEDP---QAPLLSGSA
V--------------YL---PLCRLTHCGFLA-KHLEELCKALEGSHHLARHGHL--DFS
GNALRDEGTALLAQLLPGLGPLQSLNLSENDLSLDAVFHLAQCLSTLQWVCHLEVRPQPK
TAG--------------------------------PQSLF--VCLXXLPVSSCCAKLPCP
LLP------------------LPAACP------------LFLSSILHGSATFLLRLNQTG
LS---PKSPLLLADIV----NQ-C--PRVQKVDLRSLHNVTLCFGPRKKQEVVCCG-QC-
-------------------------------LDTEASL----WGDDSWKGSNGSQEHHPG
PPL--SPSLSHNSISQEGVLHLLGTLPSCPRVRE-ASVNGPHGPHQFC------PR-PSS
L--RLNEC-SFGQEHMPRLASSISQALQ--LTELTLTQCGMDPKQLAILLRLVRRPSGLL
GLRVEEPWVGRAGVPALLEV-----CAKASPVPLSLLSISKTQ----------QQLYVQL
EFPRQEENPEASAL---------------RLTSPGM----------------FLGLFSLS
QVNLCDASD----A-SLLLQSLLLSLCQLKTFRLTSSCVSNQGLTHLAAGLGHFYHLEEL
DTKASSG-V--CTCDMPHTEMPGSSGPFFSSLSHLLLGSSTLATLTQKLSHMN

PF13516 // ENSGT00860000133673_1_Domain_13 (1794, 1892)

LLQ----
------------------------------------------------------------
-HLC-------------LSRNQIGDTGAQHLAATLPGLPRLRTIDGHTVLWLRPTLA---
------SPL------------------------------SLWVKK------GLAPWSPTD
-EGGGQGVRVSDDHPFHSLSVNGISLAGGLQLAESLTLCRHLEEVSTAGRG---HLCLKP
QREVPE--HPDRWP---------RSSLHTRPGPVGSQPSP------------------PA
-----------TGPPL------------------NPTAPTPLAD----LGLLPCRLSWNL
LGDEAAAELAQVLPRMSRLKRVDLETNRITAAGAWLLAEGLSQGSGVPVIRLWNNLVPPA
AAQRLQSQEPRLDFAFFDS---------

----------------------MDPVSLQL-GTKNLWSLLVRLLSKDPQWLNAKVKFFLP
KMDLSSRNKAEDA---TQGVMLQLNRLHTQGQATWQAFIHCVCMELDVPLDLEVPLLSTW
GHG-DGF---------------------------ASQLETGEESPPESQLHHGLKRP---
HQSCGSSPRPK-QCRKQQLGGYEELAKRYLQLLRSSAQQRYGSRTR------RPGQPL-A
FHQAYIPPILQWSRATAPFNTQEGAI---L-GDPKAEDG--TEASILDLFNT-KADKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWADGQLDRFQALFLFEFRQLNLITEFLTLPQLLFDLYL
SPEAG-PDLVFQYLEENAKGVLLIFDGLDQALHPPSSK-------DTAGPEAPSPALALF
SGLCKGTLLPGCWVLATSRPGKLPDCLPTEA-AMVHMWGFDRPRVEEYVGRFFSNQP-WQ
EAALAELRENRHLQSMCAVPAVCQVTCLCLYH-LLPSSSPGQSAA-LLPTVTQNYVQMVS
TLGPRG------------HLLPESLLGLSEVALRGLETGKVIFSVG-DIPPPMMAFGAAL
GLLTSFCICTGPGHQETGYAFTHLSLQEFFAALHLMASPEVDKNALAHYVTLSSHWVLRT
--KARLGLLD-HLPTFLAGLASRACCPFLSHVAQRDEVWVGARQAEVMQALRKLATRRLT
GPKVVALCHCVGETQEPELASLMAQSLPCHLSFHNFPLTYADLASLNNILGHRNAPIQLD
FEGCPLEPHCPEALAGCKQVENLS-FKSRKCGDAFAEALSRSLPTMGSLKKLGLAGSKIT
ARGIGRLVQALPLCPQLEEVSFQDNQLKDGVLLNIVEVLLCLPRLQKLDLSRNSVSMSTL
LCLTKVAITSPAVRMLQVREADLIFLLSPPTETAAELQGASDLQGNAS-QRKEAQSRSLA
LR----LQQCQLRVHDVQELIAQLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLDKVDLSGNQLDNEGCRLMAEAAAQLDITRN
LDLSDNGLSVDGVDGVLSAVSMCQTLAE-LHISLLHKTVVLTFAPKQE---EQGGIQERA
ALHDGLMR--QMPCELPPHSTRIRLTHCGLQA-KHLAQLCRALGG

PF13516 // ENSGT00860000133673_1_Domain_6 (1126, 1153)

SCRLSH---L--DFS
GNALGDEGVAQLAQLLPGLGTLQSLNLSENGLSLDSVFILTQCFSTLQWLFHLEVNSESQ
HV---VLRGDRT-GRDQLAG------GPLPEFPAGAQFSA--FDQRCIPRSVCLRQ--CL
LEPLSLTHLCETLEKCPGPLEVKLSCEVLSDQ----SLETLLNHLPRLPQLSLLQLSETR
LS---PRSPLLLANLF----SL-C--PQVQKVDLRSLYHTTLHFRSSEEQKGEFCGRFMD
CALSREHVEPLCWLLS-KC-ED-----

PF13516 // ENSGT00860000133673_1_Domain_9 (1408, 1431)

-LNQLDLSANL----LGDDGLQC

ENSGT00860000133673_1_Linker_9_10 (1431, 1446)

LLE---CLPQ
LPISA

PF13516 // ENSGT00860000133673_1_Domain_10 (1446, 1462)

SLDLSHNSISVEGALCLVKTLPSCPRVRE-ASVNLGSEQSFWIHFSRQEEA-GKT
L--RLSQC-SFRPEHVPRLATGLNQALK--PTALTLTQCCLGLEQLTVLLSLVRWPVGLF
NLRVEEPWVGKAGVLALLEV-----CTQASGNITE-ISIAEAQ----------QQLCLQL
EFPRQ-ENPEAVAL---------------RLAHCDLGTHHSLLVWQLMETCARLRQLSLS
QVNLCDTSS-------LLLQSLLPSLSELKTFRLTCSCVRSEGLAHLTSGLS

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1753)

HCLHLEEL
DLSNNQFGE--E

ENSGT00860000133673_1_Linker_12_13 (1753, 1793)

GTRVLMGVLEGKCWLKRLDLSHLPLGGSILAVLTQRLRHM

PF13516 // ENSGT00860000133673_1_Domain_13 (1793, 1892)

TLLQSLRL
-------------------------------------------------S----------
-------------------HNQIGDTGAQLL

ENSGT00860000133673_1_Linker_13_15 (1892, 1901)

AVVLPWLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSGNGIGPAGGARLAESLALCRHLEQLMLGCNALGDATALGL
AQGLPR--HLRILH---------LPSS--RLGPEGALSLSQALDGCPYVEEVSLAENSLA
RGIPQFC----QGLPLLRR------IDLVSCDIDDHTAKPLAASLLLCPALEEILLSWNV
LGDEAAAELARVLPQMGRLKRMDLEKNRITACGAWLLAEGLAQGSGIQVIRLWNNPIPPD
TVQRLQKQEPRLDFAFFDKQPKAPWGT-

----------------------TDPISLQL-GTENLCGCLVRLLSKDPEWLSAKVKFFLP
NMDLGSGDQSPDP---TQRVIQQLSKLHTQGQSTWQEFIHCVCMELDVPLELEVPLLSIW
GHG-DGF---------------------------PRQLDIGEESQPDSQLHPGLKRP---
HQSCGSSPRPK-QFKKQEQ----ELAKRYLQLLRTSAQQRYADRTP------RPGQPL-A
FPQVYIPPILQWSRASAPFDAQEGAV---R-GDPKAEDG--TDVNIRDLFNT-KANRGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 476)

R
VTVLLGKSGMGKTTLAHRLCQKWADGQLDRFQALFLFEFRQLNVITGFLTLPQLLFDLYL
RPEAG-PEAVFEYLQENANGTLLIFDGLDEVFQ-------------TAGPEDPASALTLF
SRLCRGTLLPGCWVMATSRPGKLPACLPTEV-ATVHMWGFDGPRVEEYVSRFFSDQP-SQ
EAALAELRADRRLWSMCALPALCRVACLCLYH-LLPGSSPGQSAA-LLPTMTQNYVQMVL
TLSPQG------------FLPAESLLGLGEVALRGLETGKVIFSAG-DIPPPVMAFGAAL
GLMTSFCVCTGPGHQETGYAFTHLSLQEFFAALHLMASPQVDKDTLSQHVTLTSRWVQRS
--KARLGLTD-HLPTFLAGLASCACRPFLSLLARQDEAWVGTKQAAVVQALRKLATRRLT
GPKVVELCHCVGETQVPELAGFIAQSLPRQMPFHNFLLTYADLAALTNILGHRDAPIHLD
FEGCSLEPRCPEALAGCGQVENLS-FKSRKCGDAFAEALSRCLPTMGSLKKLGLAGSKIT
AQGISHLVQALPLCPQLEEISFRDNQLKDWDVLSIVEVLPCLPRLQKLDLSLSKVSVSTL
LSLTNVAVTCPTVRMLQVRKADLIFLLSPPTEMATELQGDPDLWGNAN-QRKEAQRRSLA
LR----LQKCQLGVRDVEVLLAQLREGP

PF00560 // ENSGT00860000133673_1_Domain_4 (989, 1015)

HLDEVDLSGNQLEDEGCQLMAEAAPQLRIARK
LDLSSNGLSLAGVCRVLSAVSMCRTLAE-LHVSLLHKTVVLKFAPEPE---EQKVTQKRA
AFPGSLTF--QMPSDPLPCAPRIRLTHCALQA-QHLEHLCKALGGSC

PF00560 // ENSGT00860000133673_1_Domain_6 (1128, 1159)

CLCH---L--DLS
GNALGDKGAALLAQLLPGLGALQSLKLSENDLSLDAVFCLTQCFSTLPWLLHLDFSSESQ
RV---ILRGEGR-DRDLLPA------GSLPEFQAGAQFLG--FGQHRISRSFCLRE--CQ
LEPLSLSRLCETLEKCPGPLEVKLSCKVLSDQ----SLETLLHHLPRLPELSLLQLTQME
LS---PRSPLLLADIF----SL-C--PRVQKVDLRSLHHATLHFRSSEEQEGGCCGRFTG
CGLSQEHVEPLCWLLS-KC-ED------LSQLDLSANL----LGDAGLRCLLE---CLPQ
VPISGSLDLSHNGISQESVLCLVETLPSCPRIRE-ASVNLGSKQSFWVHFSRQEEA-RKT
L--RLSEC-SFGPEHVPRLATGLSQALR--LTELTLTQCFLGLEQLTILLGLLKWPAGLL
TLRVEEPWVGKAGVLTLLEV-----CAQASGNITE-ISISETQ----------QQLCIQL
EFPHQ-ENAEAMTL---------------RLAHCDLGTHHSLLARQLMETCARLRQLSLS
QVNLCEASA-------LLLQSLLLSLSELKHFRLTSSCVSSSALAHLTSGLSRCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1761)

HLEEL
DLSNNQLGE--EGTKVLTGALEGKRRLKRLDLSHLPLGASTLAALTQGLSHMTLLQSLRL
------------------------------------------------------------
-------RAAT

PF00560 // ENSGT00860000133673_1_Domain_14 (1872, 1898)

SLKELGLSHNQIGDTGAQNLAAVLPG

ENSGT00860000133673_1_Linker_14_15 (1898, 1900)

LP

PF00560 // ENSGT00860000133673_1_Domain_15 (1900, 2015)

ELRKI----------------
------------------------------------------------------------
-----------------DLSGNGIGPAGGARLAECLPLCRHLEELMLGYNALGDPTALGL
ARRLPR--

PF07723 // ENSGT00860000133673_1_Domain_20 (2049, 2087)

HLRVLH---------LTSS--HLGPEGALSLGQALDGCPHMEEISLAENNLA
GGVPHFR----LGLPLLRQ------IDLVSCEIDNQTAKPLTASFVLCPALEEIMLSWNL
LGDEAAAELARVLPQMGRLKRMDLEKNRITAYGAWLLAEGLAQGSGIQVIRLWNNPIPPD
MAQRLRSQEPRLDFAFFDNQPQVPH-GT

----------------------MDIAGIQM-GSGNTWDWLVQLLSKNPEWLSTKVKFFLP
NTDLGSSSESPDP---AQGVTLQLKLLCGRGLATWRSFIYCVCMELEVPLELEVLLLSTW
GHE-EGTLPGEMSPEQSPGVPQNPTARQSCLAGIPSPLGVGDLSWSGSQLHHGLKRP---
HHSPGPSPQWK-HCRRQRR----ELAQRYLELLRTSVQEHYGSGPP------SSGQHL-A
SLQAYIPPILQWSRATTPLDPQKGAN---S-GDPKTEDG--TDVSIQDLFSS-RSHKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 474)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGQLHRFQALFLFEFRKLNLITRLLTLPQLLFDLSL
NPEAE-PEAVFQYLQENASRVLLIFDGLDEALYPCSGR-------ETVDPHSPRPALALF
SDLCRGTLLPGCWVMATSRPGKLPTCLPTEA-AMVHMWGFDGPRVEEYVSHFFGEQT-SR
EAALAELRANRQLQNMCAVPALCLAVCLCLYH-LLPGSAPDQCAA-LLPTVTQLYMRMVL
ARSPRR------------PLPAATLLGLGEVALRGLEARKTIFYVG-DIAPPLLAFGAAH
HLLTSFRIRMGPGHWDTGYAFTHLSLQEFFAALYLMASPKVDEDTLARHITLNSRWVLRT
--KASLGL-SDHLPTFLAGLASHACRPFLSHVAQNDEARVGAKQTAVVQVLRKMAAHRFT
GPKVVELCHCVAETQVPELAQLTAQRLPYQLPFHNFPLTYTDLAALASVLEHRAGPIHLD
FEGCPLEPHCPEALAGCGQIENLS-FKSRKCGDAFAEALSRSLPTLGNLQKLGLTGSKIT
ARGISHLVQALSFCPQLEEISLHDNQLKDQEVLGLVEGLLCLALLRKLDLSRNSISVSTL
LCLVKAALTCPTVRTLQVREADLIFLLSPSVETATELQRAPDLQENVN-WKKETRTRGLA
LR----LQKCQLKVHHAEMLIALLQEGPPLEELDLSGNQLEDEGCRLLAEAAPQLHIARK
LDLSDNQLSVAGVSHVLHALSTCSTLAE-LHISLLCKTVLLTFAHEPE---EQEGAQER-
-------S--QMPAELPMGPRRIRLAHSGFQS-KHLEPLCRVLGESRCLGPLG--HLDLS
GNALGDEGAALLAQLLPGLGPLQSLDFSENGFSLDAVFSLARCLSTVQWAAHLDISFRSQ
RI---LLRGDEP-GREALAA------GPLPDCSAGAQLPG--FRPRHGPRSFRLSE--CQ
LEPPSITCLIAALQECPGPLEVQLSCEALSEQ----GLETLLCCLPRLPQLQLLQLSETG
LT---PRSPFLLAEVF----IK-C--PQVQKVELRSLRHATLLFKSSEEQGGVCCR-FAG
CGLTQEHVEPLCSVLG-KR-ED------LCQLDLSANL----LGDDGLRRLLE---CLPR
MPISGSLDLSHNSISQESVLSLLEMLPSCPRVRE-ASVSLGSEQSFWIHFSKQEEA-GKM
L--RLSEC-SLLPEQLPRLASGLSQVLQ--LVELTLSQ----------------------
------------------------------------------------------------
------------------------------------------------------------
-VNLSDDDDGD--ASSLLLRDLLPALSELKSFRLTSSCVSTKGLSHLTSGLGHCH

PF00560 // ENSGT00860000133673_1_Domain_12 (1736, 1753)

HLEEL
DLSNNQFSEIETGTLALLAALEGKRRLQRLSLTHLPLGGSTVAVLTRGLSHVALLQSFRL
-------------------------------------------------SWNHI-DDVGC
CHISEALRAATRLEELILDHNQIGDTGAWHLAAILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSANGIGPAGGVQLAASLALCRHLEELMLGSNALGDPTALQL
ARGLPP--HLRVLH---------LRSS--RLGPEGVLSLVRALDGCPHVEEISLAENSLA
QGLPRLC----TGLPQLRQ------MDLVSCEIDNQAAKHLAASFLLCPALEEILLSWNL
LGDEAAAELAQVLPQMRQLKRVDLEKNRITARGARLLAEGLAQGSGIQVIRLWNNPIPAD
AAQHLQSQEPRLDFAFFGS---------

----------------------MDPVDLQL-GNKNLWSCLVRLLSKDPEWLNAKMKFFLP
NTDLDSRNETLDP---EQRVILQLNKLHVQGSATWQSFIHCVCMQLEVPLELEVLLLSTF
GCD-DGF---------------------------TSQLGAEGKSLPKSQLHQGLKRP---
HQSCGSSPHRK-QCRKQQL----ELAKKYLQLLRTSAQQRYGSRIP------GSGQPH-A
LHQVYVPPILRR--ATASLDTQEGAI---M-GDLKVEDG--TDVSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITRFLTLSQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPMGPDGPGSVLTLF
SRLCRGTLLPGCRVMATSRPGKLPACLPAEA-AMVYMLGFDGPRVEEYVNQFFSAQS-LQ
EGALAELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSVA-LLPTMTQLYMQMVL
ALSPHG------------HLPTTSLLDLGEVALRGLETGKVIFYAK-DIAPPLIAFGATH
SLLTSFCVRTGPGHQQTGYAFTHVSLQEFLAALHLMTSPKVDKDTLTQHVTLHSRWVQRT
--KARLDL-SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGTKQAAVVQVLKKLATRKLT
GPKVVELCHCVNETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLHIVEVLPHLPRLRKLDLSGNSVCVSTL
LCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAETLIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHITRK
LDLSDNGLSLAGVHCVLRAVSACWTLAE-LHISLRHKTVVFMFAQEPE---EQEGPQERA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGATRLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSSPDFPAGAEFLG--FRRRCIPRSLRLSE--CP
LEPPSLTHLCATLKECPGPLELQLSCEFLSDQ----SLETLLDCLPRLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCRLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPQ
VPISGSLDLSHNSVSQESALYLVETLPSCPRVRE-ASVNLGSEQSFRIHFSKEDQA-GKT
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLDQEQLAILLSLVGRPAGLF
SLRVQEPWADRAGVLSLLEV-----CAQASGSVTE-ISISKTQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLMETCARLQQLSLS
QVNLCEDND-D--SS-LLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1792)

MRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSH

PF13516 // ENSGT00860000133673_1_Domain_13 (1792, 1860)

MTRLRSLRL
-------------------------------------------------KRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

PSLEELDLSHNQIGDAGVQHL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGMQLAESLILCRHLEELMLGCNALGDPTALGL
ARELPQ--HLRVLH---------LPFS--HLGPGGALSLTQALDGSPHLEEISLAENNLA
GGVLRFC----KELPLLRQ------IDLVSCKIDNQTVKLLTSSFTRCPALEVIL-----
------------------------------------------------------------
----------------------------

----------------------MDPIGLQL-GTRNLWSWLVRLLSKDPEWLNSKMKFFLP
NTDLDSRNETSDP---EQRIILQLRKLHVQGLATWQSFIHCVCMELEVPLDLEVPLLSTW
GCD-DGL---------------------------TSQLGAEEKSQRESQLHRGLKRP---
HQSCGSSPCRK-QYRKQQL----ELAKKYLQLLRTSALQRYGSRIP------GSGQPH-A
FHQAYVPPILRR--ATAPLDTRGGAI---M-GNPRVEDG--TDVSISDLFNT-RTNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTILLGKAGMGKTTLAHRLCQKWAEGQLDCFQALFLFEFRQLNLITRFLTLPQLLFDLYL
SPESD-PDAVFQYLEDNADQVLLIFDGLDEAL-------------QPEDPDGPGPVLALF
SGLCHGTLLPGCWVLATSRPGKLPACLPSEA-AVVHMLGFDGPRVEEYVNCFFSTQS-SR
EGALGELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSAA-LLPTMTQLYMQMVL
ALSPRG------------HLPTTSLLGLGEVALKSLETGKVTFYAR-DIPPPLMAFGATH
SLLTSFCICTGPGHQQTGYAFTHFNLQEFLAALHLMASPKVDEDLLTQHVTLNSRWVLRT
GPKAKLDL-SDHLPTFLAGLASCTCRPFLSHMAQRGEDWVGTKQAAVVQALKKLATRKLT
GPKVVELLHCVNETQEPELASLTAQSLPYQLPFHNFSLTYTDLAVLTNILEHREAPIHLD
FEGCTLEPHCPEALVGCEQIENLS-FKSRKCGDAFAEVLSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFQDNQLNDQVVLNIVEVLPH

PF13516 // ENSGT00860000133673_1_Domain_3 (882, 895)

LPRLRKLDLSGNN

ENSGT00860000133673_1_Linker_3_4 (895, 988)

ICVSTL
LCLTKVAVTCPTISMLQAREADLIFLLSPPKETTAELQRAPDLQESDG-QRKEAQSRSLT
LR----LQKCQLQVHDAETLIALLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAVSQLHITRK
LDLSDNGLSVAGVHCVLRAVHACWTLTD-LHISLLHKTVVFMFAQDPE---QQEGSQNRA
AFLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWVFHLDISFERQ
RI---LLRGEKT-GRGIWTT------GSLPDLPAAAELSG--FRWRCTPRSLCLTE--CP
LEPLTLTRLCATLEVCPGPLEIQLSCEVLSDK----SLETLLHCLPQLPQLSLLQLSQTA
LS---PRSPFLLADIF----SL-C--PRVKKVDLRSLHHSTLHFRSNEEQEGVCCGRFTG
CSLSQEHVESLCWLLS-KC-ED------LSQV----------------------------
------------------------------------------------------------
------------------------------------------------------------
--EVQEPWVDQAGVLSLLEV-----CAQASGNVTE-ISISETQ----------QQLHVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVRQLMETCARLQQLSLS
QVNLCEDGD-S--SS-LLLRSLLLSLSELKKFR---------------------------
-------------------------------LSHLLLNGSTLDLLTRGLSHMTLLQSLRL
-------------------------------------------------NRNSI-GDVDC
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSYNQIGDAGVGYLATILPRLPELRKI----------------
------------------------------------------------------------
-----------------DLSANSISPAGGVKLAESLALCRCLEELMLGCNDLGDHTALEL
AQELPQ--HLRVLR---------LPSS--HLGPKGALSLVQALDGSPHVEEISLAENNLA
EGVPRFC----KGLPLLRR------IDLVSCKIDNQTAKLLTSSFTLCPALEVILLSWNL
LGDEAAAELAQVLPRMGRLKRVDLEKNQITARGAWLLAEGLAQ-SSVQVIRLWNNNIPCN
VAQSLQSQEPRLDFAFFDNQPQAHWGT-

----------------------MDPIGLQL-GTRNLWSWLVSLLSKDPEWLNSKMKFFLP
NADLDSRNEPSDP---EQRIILQLRKLHVQGVATWQSFIHCVCMELEVPLELEVPLLSTW
GCD-DGL---------------------------TSQLGAEEKSRRESQLHHGLKRP---
HQSCGSSPCRK-QCRKQQL----ELAKKYVQLLRTSALQRYGSRIP------GSGQPH-A
FHQAYVPPILRR--ATAPLETQGGCI---V-GNPRVEDG--TDVSISDLFNT-RTNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTILLGKAGMGKTTLAHHLCRKWAEGHLDCFQALFLFEFRQLNLITRFLTLPQLLFDLYL
SPESD-PDAVFQYLEKNADQVLLIFDGLDEAL-------------QPEDPDDPGPVLALF
SGLCHGTLLPGCWVLATSRPGKLPACLPTEA-AVVHMLGFDGPRVEEYVNRFFSAQP-SR
EGALEELQTNGRLRSLCAVPALCQVACLCLHH-LLPDHAPGQSAA-LLTTMTQLYMQMVL
ALSPRG------------HLPTTSLLGLGEVALRNLETGKVTFYAR-DIPPHLMAFGATH
SLLTSFCICTGPGHQQTGYAFTHFSLQEFLAALYLMASPKVDKDLLTQHVTLNSRWVLRT
GPKAKLDL-SDHLPTFLAGLASCTCRPFLSHLAQRGEDWVGTKQAAVVQALKKLATRKLT
GPKVVELLHCVDETQEPELASLTAQSLPYQLPFHNFPLTYTDLAILTNILKHREAPIHLD
FEGCTLEPHCPEALVGCGQIENLS-FKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFQDNQLNDQVVLNIVEVLPYLPRLRKLDLSGNSICVSTL
LCLTKVAVTCPTISMLQAREADLIFLLSPPMETTAELQRAPDLQESDG-QRKEAQSRSLT
LR----LQKCQLQVHDAETLIALLREG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1008)

PHLEEVDLSGNQLEDEGCQLMAEAVSQLHITKK
LDLSDNGLSAAGVHCVLRAVRACWTLAE-LHISLLQKTVVFMFAQDPE---QQEGPQNRA
ASLDSLML--QMPSELPLSSRRMRLTHCGLQA-KHLEQLCKALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPELGALQSLNLSENGLSLDAVLGLTRCFSTLQWVFHLDISFERQ
RI---LLRGDKT-GRGIWTS------EPLPDLPAAAEFLG--FRRRCIPRSLCLSE--CP
LEPQTLTHLCATLEACPGPLELQLSCEVLSDQ----SLETLLHCLPRLPQLSLLQLSQTG
LS---PRSPFLLADIF----SL-C--PRVKKVDLRSLHHASLHFRSNEEQEGVCCGRFTG
CSLSQEQVESLCWLLS-KC-ED------LSQVDLSVNQ----LGDGGIRSVLE---CLPQ
VPISGSLDLSHNNASQESALCLVETLSSCPRVRE-ASVNLGSEQSFQIHFSKEDQA-GKT
L--RLSEC-SFRPEHVFRLAVGLSQSLQ--LTELMLTQCCLGQEQLTTLLSLVQRPAGLF
SLRVQEPWVDQAGVLSLLEV-----CAQASGNVTE-ISISETQ----------QQLRVQL
EFPRQEENPEAVAL---------------RLAHCGLGTHHSLLVRQLMETCARLQQLSLS
QVNLCEDDD-A--SS-LLLRSLLLSLSELKKFRLTSSRVSTAGLAHLASGLGRCHHLEEL
EWSNTEFDE--TGTKVLMRALEEKRTLKRLDLSHLLLNGSTLALLTRGLSHMTLLQSLRL
-------------------------------------------------NRNSI-GDVDC
RHLSKALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNQIGDAGVRYL

ENSGT00860000133673_1_Linker_14_15 (1892, 1901)

ATILPGLPE

PF13516 // ENSGT00860000133673_1_Domain_15 (1901, 2013)

LRKI----------------
------------------------------------------------------------
-----------------DLSVNSISPAGGVKLAESLALCRRLEELMLGCNDLGDRTALEL
ARELPQ--HLRVLH---------LPSS--HLGPNGALSLVQALDGSPHVEEISLAENNLA
EGVLHFC----KGLPLLRR------IDLVSCKIDNQTAKLLTPSFTLCPALEVILLSWNL
LGDEAAAELAQVLPRMGRLKRVDLEKNQITARGAWLLAEGLAQGSSVQVIRLWNNHIPCN
MAQCLQSQEPRLDFAFFDNQPQAPWGT-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------

PF05729 // ENSGT00860000133673_1_Domain_0 (310, 475)

MGKTMLMHRLCQKWAEGALHQFLFTFLFEFRQLNLISRKLTLKELLFDLLL
QPEDS-PDAVFQHLVENAQRTLFIFDGLDEFVGNISQPSSA---GVSPALLRSMSISELF
ANLCFGKLLPGCTVLVTSRPKKLPGFLLSRADLLAEIWGFDHERVEEYASQYFHEHF-FK
DQAIAHLKNNSKLMSMCFIPALCCIVCVCLEYLLRN----RLLNVELPQTMTQFYIKMLL
IFISKQQTEDTVSEDKQLNLHRMAILGLCDLALKGLEEKKIVFYVN-DIPEHVKAFASLH
GLLTVFEVKMSDSLPEAGHAFVHLSLQEFFAALSLMINSAVDGNYLKRKFSLKSKWTLKN
--ETRTEF-MENFHIFLSGLSSKECRTFLTMLSEQSQAWVQDKQAAILQSLRKLAATNLT
GPKIIELCHCTYETQDLELAQHVGSQLNFKYEFRNFRLTPLDVSALVFVINCGRDLTQLD
FAGCPMELDCLEVLASCKNIEHLR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------

-----------------------TPKTEALGAHGETWSCLGQARPVREE---RGLLSFLT
SSQ---------------N---ACAPLELIPSGSWGGTDPPM------------VLL-TP
PPS-PHH---------------------------TYTPGARGSQQPNTET-----RR---
HEQRARGSCPH-AMSLPLA----ELAKKYLQLLRTSAQQRYRSQIP------GSGQPH-A
FHQVYVPPILRR--ATASLDTLEGAI---M-GDLKVEDG--TDMSISDLFNT-RVNKGP

PF05729 // ENSGT00860000133673_1_Domain_0 (300, 475)

R
VTVLLGKAGMGKTTLAHRLCQKWAEGHLDCFQALFLFEFRQLNLITGFLTLSELLFDLYL
SPESD-HDAVFQYLEKNADQVLLIFDGLDEAL-------------QPRGPDSPGPVLTLF
SHLCHGTLLPGCRVMATSRPGKLPACLPAEA-AMVHMLGFDGPRVEEYVNHFFSAQP-SR
EGALVELQTNGRLRSLCAVPALCQVACLCLHH-LLLDHAPGQSVA-LPPTMTQLYVQMVR
ALSPPG------------RLPTTSLLDLGEVALRGLKTGKVIFYAE-DIAPPLIAFGATH
SLLTSFCVRTGPGHQETGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRT
--KARLGL-SDHLPTFLAGLASCTCHPFLSHLAQDSKDCVGAKQAAVVQVLKKLATRKLT
GPKVVELCHYVDETQEPELASLTAQSLPYQLPFHNFQLTCTDLATLTNILEHREAPIHLD
FDGCPLEPHCPEALVGCGQIENLSDFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKIT
ARGISHLVKALPLCPQLEEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL
LCLARVAVTCPTVKMLQAREADLIFLLSPPTETTAELQRSPDLQESDG-QRKGAQSRSLT
LR----LQKCQLQVHDAEALIALLQEG

PF13516 // ENSGT00860000133673_1_Domain_4 (988, 1007)

PHLEEVDLSGNQLEDEGCRLMAEAASQLHLPG-
-----NGL--------------TWVIDTFVKYLLQHKTVVFMFAQGPE---EQEGPQERA
AFLDSLML--QMPSELPLSSQRMRLTHCGLQA-KHLDQLCEALGGSCHLGH---L

PF13516 // ENSGT00860000133673_1_Domain_6 (1136, 1153)

HLDFS
GNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLARCFSTLQWLFHLDISFESQ
HI---LLRGDKT-GRDIWAT------GSLPDLPAGAEFLG--FRQRCIPRSLCLSE--CP
LEPPSLTRLCATLKDCPGPLELQLSCEFLSDQ----SLETLLDCLPQLPQLSLLQLSQTG
LS---PKSPFLLANTL----SL-C--PRVKKVDLRSLHSATLHFRSNEEQEGVCCG-FTG
CSLSQEHVESLCWLLS-KC-KD------LSQVDLSANL----LGDSGLRCLLE---CLPK
VPISVESSINDKYWA---------------------AVPTGLTQA--------LRW-LSA
L--RLSEC-SFRPEHVSRLATGLSQSLQ--LTELTLTQCCLGQKQLAILLSLMGRPAGLF
SLRVQEPWADRAGVLSLLEV-----CAQASGSVTE-ISISETQ----------QQLCVQL
EFPRQEENPEAVAL---------------RLAHCDLGTHHSLLVGQLIETCARLQQLSLS
QVNLCEDDD-A--SS-LLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLG

PF13516 // ENSGT00860000133673_1_Domain_12 (1733, 1758)

HCHHLEEL
DLSNNQFDE--EGTKAL

ENSGT00860000133673_1_Linker_12_13 (1758, 1791)

MRALEGKWMLKRLDLSHLLLNSSTLALLTHGLS

PF13516 // ENSGT00860000133673_1_Domain_13 (1791, 1860)

HMTCLQSLRL
-------------------------------------------------NRNSI-GDVG

ENSGT00860000133673_1_Linker_13_14 (1860, 1871)

C
CHLSEALRAA

PF13516 // ENSGT00860000133673_1_Domain_14 (1871, 1892)

TSLEELDLSHNRIGDAGVQHLATILPGLPELRKI----------------
------------------------------------------------------------
-----------------DLSVNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALAL
AQELPQ--HLRVLH---------LPFS--HLGPGGALSLAQALDGSPSLEEISLAENNLA
GGVLRFS----KELPLLRQ------IDLVSCKIDNQTAKLLTSSFTSCPALEVILALSWL
GKGKAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCD
MAQRLKSQEPRLDFAFFDNQPQAPWGT-