Query Results 

------------------------------------------------------------
-----------------------------------------FAQANQFNYGVHNELLGNS
VHFVSATQSIPCDVEKDASHSTHITCYTRAMPQDTYTVKVSVDGVPITNDNICRGHVNSW
ACSFQT-------KNFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNITPLTGLPGSLITIRGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLFPQSDNLYGLKLDHENSDMGTMICKMTGSYIGKCHHNVSFILD-S
DYGRSFPQLSA-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFISSLNKI-AMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 450)

AEVTKISPS
QGSIEGGTLLT-ITGHFFDQTDSPVRVIIGGQS----CEVLRLTENNIYCRTPP-KPS-V
LRTVYPGGRGLKLEVWNNSRPTHLEEILEYNESTQGYMGSTWVDTASYVWPMEQDMFVAR
FSGFLVAPNSDGYRFYIKGDDRYAVYFSPTGNPT--DKVKIAYHSSYANSYFSSLTQRSD
VFQLQKGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXVITLENWKTTNPNNEIQKITVSSPCMKSNTCSFYQYSLIYNQEKT----VLLPADASD
IAMESSLNALLSIQPDVVHVVRK-EGSQSYVYTVTFKSARGDFDLITYEVLEGSNITVDI
VEQTKGIPSLDTFTLTWDGISSKPLTPWSSENEVQAALEEMVSAKCPKEIAHLKEGFAVK
YFKDYETDFSMXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XFCLAYKGFLANHIGLKFQYEDSKSKETKSTFMQFSFPFIQGS-XXXXXXX-XXXXXXRK
YSGKNL-LQRISLQKASEVQSFYVDAVYLGQRATISNTDEVPKRRLPALSSRGIFLKHFQ
VKQTEIVRSSVTIQYTVTMTSCNCSYRIPLLAVGFAQXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXXXAVDQYALQSI-QMGQVSVTREGSCA
GYSWKIKWRSACGKQNLLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---
XXXXXXXXXXXXXXXXX--XNEITCRILNGTAGNFPVAVFVAEMGLAHHTGG-EMFSFTY
T

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

TQIVHVWPASGSLG-GGTLLTLSGFGFGEDTRILVGNKSCTVIKGNMNEIKCRTPKGAE
GTFDVIVITNGLHASANSAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNISQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1446)

PTILYFSPKTRM-----ILGEVNLTIKGYNFGN
EHSQNT-VYVGGANCTVLHWNFTDI-TCLLPKL-------SPGNYDICVEVGNWGFASS-
SEELN

ENSGT00780000121902_0_Linker_7_8 (1446, 1452)

VSIQYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LQVTNIFPQKGSLYGGSE-ITLMGFGFSTTPDENKVFFXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXYGEGYAWSPSVLNISVGDMVIWQWQAQPFVRGIGY
RVFSVSSPGNVIYDGKGFTSGNQKTTSGSFSYQFTSPGIYYYSSGFINEAQSIFLQGVIN
VLPAENKYIPLHLFLGGTEATYAE----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAINTLTKELERRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PHIDTVTPNVGSTN
GMTRVTIKGSGFAASSAYIKAVIGGFPCTILSVNYTMIECETSPAPEQSMNIDLQIHDIP
AQCQENCNFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDSVT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

PIVTGVFPNITK--STKFLIEGQGLEN-VEDVLIYIGDRQFRAV
DVNDTSITVVVNAIPAGYYPLRVIVMTKGLAAGNFT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VTS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PLVASLLPASGSTEGGTALII
TGNGFSPGNTTVTIGDNQCKIVSITPRKIHCDTPARSAATVHMRILINSFVSPPLLFTYS
LDETPFLEDVVPNR-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNITMINDNILRCRVG
NHAGGIFPVMLRHLTKGYAVSRIAFEYS

PF01833 // ENSGT00780000121902_0_Domain_15 (2129, 2311)

LTIQNFFPRQG-SFCGGLTMTVIGSGFNPQSS
MVSVCNTECEVDRLQSDYETLYCKVPFNNX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX-
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTEDVRITIGQAVCDVESTNETHIICI
TNAHSLSQWAKIYVSIGSNGIAKLDNADFLYIDVWSSSFSWGGQSPPEEGSLVVITKGQV
ILLDQSTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXLPIPVTWTRLAQTAEAGESTLVLQEAVTWNVGD
EIVIATTGHRHSQRENEKKTIASISEDGMSVKLTNPLKYTHLGKTITLPDGALFEARAEV
GVLTRNILVRGSNNIVWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGACIMFHA
PGPSADLVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLKFRSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDPNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTIPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNDDVGIET
KRILATYVGGWGEINGALIKNAKIVGHLDELGLGPSYCTSKGLLLPFNEGLTVSSVHFMN
FDRTNCVALGVTSILGVCSDACGGWSARFMDIHYFHAPNKAGFRWEHEVVLIDVDGSLTE
HKGHSVVPHSSLLDLAHCKQETEWSIGFPGSVCDSSVSFHRLAFNKPSPISLLEKDVILS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVEHITNISYASTFYGFRDEDYVI
ISHNFTQKADMFNIVDIRNGSSNPLDLNTSRNGDWHLEKNTSTLYYLVSGRNYLPSNQAI
SRTLDPDVKDVIVNFQAYCCFFQDCFPINSSTQIPLPRKRPEMYNLWSNDSFWQSSPENN
YSIPQEGANVVIPEXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXGGRLIGGWEDNPFKGELQIILRGSHSTPEWSLPNGPNQGSKVLGIFGELDLHGIT
RAVYKTKLSKTALAGSKVISLMDAVDWKVGEDIVITTTSYDSRQTETRRITQILADQRSF
ILNDSLSYTHIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLK-IWGN-GNRVRGNLVSFSVWPGTYQNKKE
LTSTLWHAAIEINMGTNTILQDNVVAGFERIGYHIDGEPCADQTNSAGKWHNNEAHGGLY
GVYMNQDGFPGCSHI-----QGFTVWKCWDYGIYFQ----------------TTESVQVS
NVTLVDNGMGILPIIYLPAATSHKISKKTVRIKNLLVVGSSPQFNCSDVLTNDDPNIELT
AAHRSARPP--------------------SG--GRSGICWPTFASAHNMAPRKAHAGLMS
YNAIXXXXXXXXXXSTFVGFKNVCSNETAVMFMTNPLNEDLQHPIHVKNIQTVNTIEQSK
IFIHRPDLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXIVRDSTCKYISEWQSYQCFGMEYAMMVIESLDS
DTEIRRLSPVAIFADGYVDLIN--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXAVRVAIFFSTLQRLDVYVNNSLVCPKNTVWNHQQKDCEFN--I
HLESGEYLPSLNSAISGENYFDRTYQMLYLLVKGPTPVEVHTTAVLFVSFKLPAIXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXX-XXXXX--XXXXXQAIILGKINSILGFNVSSMSISDPLPTPSDSGWIQVT
AQPVERSA--FPINHLAFVSSLSVITQPVAGLPGHLFSQQPSIKAMDSDGNCVSVGITSL
TLKAILKDASNNQVSGLSGNTSVPFSSCWANYTDL---TLIKAGKNYKIEFVLNDVRVE-
-----SRSFSLPVQSSSSSSD---------------------------SKSLNMGSAAQK
VTIVVGCLLGGRLLLEIFMTAVLILKETVGNQ----------------------------
-------------

----------------------------MEP-QR--VCAT---LYLLAL-------LLRA
AEHGT-----DGLKMI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEIFPKYGSINGATRLTIKGEGFAQANQFNYGVDNELLGNS
VHFVSATRSIPCDVEKDASHSTHITCYTRAMPEDTYSVKVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVAVKNDNICRGHINNW
ACSFQT-------KNFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNITPLTGLPGSIITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLIPQSDNLYGLKLDHQNSDMGTMICKMTGTYIGHH--NVSFILD-S
DYGRSFPQLST-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFISSLNKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 418)

EVTKISPS
QGSFQGGTLLT-ITGHFFDQTDSPVRVIIGGQN----CEVLRVTENNIYCKTPP-RP

ENSGT00780000121902_0_Linker_3_4 (418, 430)

S-V
FRTTYPGSR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 564)

GLKLEVWNNSRPTHLEEILGYNESTPGYMGDTWVDTASYAWPMEQDMFVAR
FSGFLVAPDSDGFRFYIKGDDRYAVYFSPTGNPE--DKVKIAYHSSYANNYFSSWTQRSD
VFQLQKGKEYYIEILLQEYGQSA

ENSGT00780000121902_0_Linker_4_5 (564, 1168)

FVDVGLYQFKNFYTEQQTRDAVNEEQVIQTQSTIVQE
IQVITLENWTTTNPKNEIQKVTVSSPCMKSNACSFYQYKLIYNKEET----VLLPVDSSD
TAMESALNALLSIQPDAVHVVRT-EDEQSYVYTVTFKSVRGDFDLITYEILEGSNITVDI
TEQTKGIPSLDTFTLTWDGISSKPLTSWSSENEVQTALEEMVSARCPKEIAHLKEGFAVK
YFRDYETDFSLKHINRGQITSETLAYCGRFSLKNPALLFDSEDVKPNGMPYGNMSLFLYN
QFCLAYKGFLSNHIGLKFQYQDSKNKETKNTYMQFSFLFIQGS-NWTYTCIDLLHLIQGK
YSGKNFFLQSIVLQKASETQSFFVDVVYLGQIATISTTDDVPKRRLPALANRGIFLKYFQ
VRRTKMVRSPATIQYTVTMISCNCSYRIPLLAVGFAQVITNNTENESMYRGMNWPGGSQI
RIQRTQAASPPIRGSFDIQAYGHILK-GLSADISAVGLQYALQSIPEMGQVSVTREGSCA
GYSWKIKWRSACGKQNLLQIKDFNITGEKANI--TVTKITEGGLFRQHILGDLLRTPNQQ
PQVEIYINELPAKCSGNCGYKWDALNT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PIILAINPTQGSYEEKTILTISGSEFSPNL---
ATSVTVGSVDCPVLSVN--ENEIKCHILKGKAGKFPVTVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

EMGLAYPEGG-VMFNFTY
NTQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1341)

ILHIWPTSGSLA-GGTLLTLSGFGFSKDSKILIGKKSCDVIKGDLNEIRCRTPKASE
GTFDVTLMTNELQASANAAF

ENSGT00780000121902_0_Linker_6_7 (1341, 1348)

SFNISQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PVIMSFSPKIRM-----LLGDVNLTIKGYNFGD
EHLQNM-VHVGGSNCTVLHWNFTDI-ICLLPIL-------PPGNYDICVEVGNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFASP-
SEQLNVSIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1512)

QVTNIFPQKGSLYGGSE-ITLMGFGFSTTPDENSVFFGSFPCNVTSSS
ETSITCILHST

ENSGT00780000121902_0_Linker_8_9 (1512, 1693)

KNVFRVTNQGKDSVYGEGYAWSPSVLNISVGDTVIWQWQAQPFIRGIGY
RVFSVSSPGNVIYDGKGFTSGSQKTTSGSFSYQFTSPGKYYYSTGSINEAQTIFLQGVIN
VLPAENKYLPLRLFIGGIEATYAP----EGSNESSTRISVADHIGEEPSCVQNNTGIKNL
NGIFFELSSCYS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1769)

PSINSISPSYGSVNEVITITGHRFSNLGYANKV-TIGGYPCVIEESSE
NVIMCHIDPQNSMAVGIGELVSLIVHNL

ENSGT00780000121902_0_Linker_9_10 (1769, 1787)

GAAVNTLTKELERRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1863)

PHVDTVTPNVGSTK
GMTRVIIKGSGFAASSDHIKATMGGFPCTILSVNYTVIECETSPAPEQHVDIDLQIHDIP
AQ

ENSGT00780000121902_0_Linker_10_11 (1863, 1877)

CKGKCSFSYLDIIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1955)

PFVTKVFPNTLQNVSTKVLIEGQGFGECLEDILIYIGDRQFKAV
DVNNTSISVVVNAVPAGYYPLRVIVMTKGLAAGN

ENSGT00780000121902_0_Linker_11_12 (1955, 1963)

FTVNSPLA

PF01833 // ENSGT00780000121902_0_Domain_12 (1963, 2039)

ASLLPASGSTEGGTALII
TGNGFSPGNTTVTIGDAPCKIVSITPSEVLCNTPARPASTVLVKILINSFAFPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YS
LDDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKDVAPAR-GSPGTEIEIIGSSFGFDISEVVVTIDDAQCNITMVNDSILHCRVG
DHAGGIFPIMLRHLTRGYAVSRTVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YSL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TVQNLSPRQGRSFGGGLTMTVIGSGFNPQSS
TVSVCGTECEVDRLQSDCNTLFCKVPLNNG-NGAHQDCEVRV---ANGEFSTKSNTAFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MASLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PVITEVAPRRGGTEGGTRLMIKGSGFSSNMEDVHITIGQAECDVESTNETHIICI
TNAHSPSQWVKIYVNIG

ENSGT00780000121902_0_Linker_15_16 (2298, 2320)

NNGIAKLDIADFLYIDVWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2439)

SWGGQSPPEEGSLVVITKGQI
ILLDQSTPVLKMLLIQGGSLIFDEADIELQAENILITDGGTLQIGTEASPFQHKAIITLH
GHLRSPELPVYGAKTLAIREGILDLHGLPIPVTWTRLAQTAEAGESTLVLQEAVTWNVGD
KIVIATTGHRHSQRENEKNTIASISEDGMTVKLTNPLKYTHLGKTITLPDGTSFEARAEV
GVLTRNILVRGSNNVVWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGACIMFHA
PEPSANLVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLKFSSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEYGNVLQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTLRHNAAAGGTHFGFWYRMNNHPDGPSYDPKICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPLPAVFKSLTTWNCQKGAEWVNGGALQFHNFVMINNDDAGIET
KMILAKYVGGWGEINGALIKNAKIVGHLDELGLGPSYCTSKGLLLPFNEGLTVSSVDFMN
FDRPNCVALGVTSILGVCNDACGGWSAKFMNIKYFHAPNKAGFRWEHEVVLIDIDGTLTE
HKGHSVVPHSSLLDLAHCKQETEWSIGFPGSVCDSSVSFHRLAFNKPSPISLLEKDVILS
DSFGN-IIPFQKKRLTHMSGWMALIPNANHISWHFKGVEHITNISYASTFYGFKDEDYVI
ISHNFTQKADMFNIIDMRNGSLNPLDLNTSRNGDWHLEKNTSTLYYLVSGRNDLPSNQAI
SKTLDPDVKDVIVNFQAYCCFFQDCIPIDSPKRIPLPRKRPEIYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSPENN
YSIPQEGANVVIPEDTWMVMDVDIPSLEKLIILGVLEVEDKKNNISIGRSIYRKVVLNAT
YISVQGGRLIGGWEDNPFKGELQIILRGSHSTQEWPLPNGPNQGSKVLGIFGELDLHGIT
RTVYKTKLSETAFAGSKVISLIDAVNWEVGDDIVITTTSYDPRQTETRRIAQVLADQRSL
ILNYSLSYTHIAEKYHIQSTGQKYTLAADVGILSRNIKIIGEDYPDLFKESFGARVLVSS
FTKNMVTYIGNAR-ISNVEFYHSGQEGYRSNMDPRFSLAFLNLGQEQEYSSSYIRGCAFH
NGFSPAIGVFGTGGLDIEDNIIHLTVGEGLK-IWGN-GNRVRGNLVSSTIWPGTYQNRKE
LSSTLWHAAIEINMGTNTILQDNVVAGFERIGYHIAGEPCPDQANSAEKWHNNEAHGGLY
GVYMNQDGYAGCSHI-----QGFTIWKCWDYGIYFQ----------------TTESVQVS
NVTLVDNGMGILPIIYMPAATSHKISSKTVQIKNLLVVGSSPQFNCSDVLTNDDPNIELT
AAHRSTRPP--------------------SGR-GRSGICWPTFASAHNMAPRKPHAGLMS
YNAISGLLEVSDS--TFVGFKNVCSDETAVMFMTNPLNEDLQHPIHVKNIQMVDTTEQSK
IFIHRPDLSKVNPSDCIDMVCDAKRKAFLKDIDGSFLGSPGSVIPQAEYEWNGNNQLGVG
DYRIPKVMLTYLNGSKIPVSEKAPYKGIIRDSTCKYISEWQSYQCFGMEYAMMVIESLDS
DSEIRRLSPVAVFADGYVDLIN--GPQDHGWCSGYTCQKRLSLFHSIVALNKSYEIYFTG
TSPQKLRLMLLNVEQNKVVRVAIFFSTLQRLDVYVNNSLVCPKNTVWNHQQQDCEFS--I
HLQTGEYLPTLNSAVSGENYFDRTYHMLHLLVKGPTPIEVHTTAVLFVSFKLPAMTEDHF
YSSNNLVRNLASFLKIPANKIRITKIIRENG--RRKKRMA-VIDIELEIGEPPAQILSNH
TTGISQMQLS-VLQEI--ASYLGQAVILGKINSVLGFNISSMSISNPLPTPSDYGWIQVT
AQPVERSA--FPINYLAFVSSLSVITQPVAGLPGHLFSQQPSIKAMDSDGNCVSVGITSL
TLKAILKDANNNQVSGLGGNTTVPFSSCWANYTDL---TLIKTGKNYKIEFVLNNVRVE-
-----SRSFSLPVQSISSSSD---------------------------NKSLNMESAAQK
VTILVGCLLGAKLLLEILMTAILILKGTTDQINEVL------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNA
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 426)

EVTMIFPS
QGSIRGGTTLT-ISGRFFDQTDFPVRVLVGGEP----CDILNVTENSICCKTPP-KPP-I
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 456)

PGGRGLKLEVWNNSRPVRLEEILEYNEKTP

PF07691 // ENSGT00780000121902_0_Domain_4 (456, 558)

GYMGASWVDSASYIWLMEQDTFVAR
FSGFLAAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVIRT-QIPQSYVYMVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDTQFTYIFAYGN-NWTYTCIDLLDLVRTK
YTGTNISLQRISLHKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
RIRRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLEGMGRISVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHVLGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSNIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCSLLSVD-E-KELKCQILNGSAGHAPVAVSMA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAY----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1761)

PSISNITPSTGTVNELITIIGHGFSNLPCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGIRET

ENSGT00780000121902_0_Linker_9_10 (1761, 1787)

VTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFTCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSISVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAMSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVVGSGFSENIEDVHITIAEAKCDVEYSNKTHIICM
TDAHTLSGWAPVCVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNIEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGIGSAFCTAKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYSRTMNKAGFRWEHEMVMIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHLSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPASRKPIPKKRPVTYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKLSETALAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHFAEKYHVPGTGESYMLAADVGILSRNIKIVGEDYPSWSEDSFGARVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKSVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
ATHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLPVATEDDF
YTSHNLVKNLALFLKIPSDKIRISK-IRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVGV-
----ESRTFSLLAESVSSSGSSSSSSSS-----------S-GSSSSSNSNASTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVST-YITLSKYSPL---IHYFSTC---------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLDKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDTLNVTEKSICCKTPP-KPH-I
LKAVYPGGRGLKLEVWNNSRPIHLEEILEYDEKTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKLYSLV-----------------
----TLFSRYYIEILLQEYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSSKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRNTDIQFTYDFAHGN-NWTYTCIDILDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVVYIGQTATISTLDEMPKRRLPALENKEIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEGLGRVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTAGDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1441)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIHVEVRNWGFASI-
RYDNEHKLDGVVEHMGLA----LTFRGCS-LYLS---TSSFAKYYLFFLGSIPCNVTSSS
ENVIKCILHSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPESVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITIIGHGFSNLTCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVNCRTPAGTTGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGTEILEILVMINNIQCNITMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITVVSPRRGSTAGGARLTVMGSGFSENVEDVHITIAEAKCDVEYSNKTHIICV
TDAHTPSGWAPVHVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFLHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIAAVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVYFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADTDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSNILYLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIIGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLRQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IYIHRPDISKVNPSDCIDMVCDAKKKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYVPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNADHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGTTPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRRKSLR--RKRSM-GFIIEIEIGDPPIRFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIRVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSG----------------------SSSSSSTSTVGTYAQI
ITVVISCLIGRMWLLEIFMAAVSTLKITLSKYSPL---IQYFSTY---------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 305)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYVGGMPCDLLIPQSDSLYGLKLDHPNGDMGSMVCKTTGTFIG--KSENLIF----
-FNR

ENSGT00780000121902_0_Linker_2_3 (305, 353)

SFPQKMA-YFVSSLNKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 432)

EVTMIFPS
QGSIRGGTTLT-ISGRFFDQTDFPVRVLVGGEP----CDILNVTENSICCKTPP-KPH-I
LKTVYPGGRGL

ENSGT00780000121902_0_Linker_3_4 (432, 456)

KLEVWNNSRPVRLEEILEYNEKTP

PF07691 // ENSGT00780000121902_0_Domain_4 (456, 558)

GYMGASWVDSASYIWLMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYRNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLSADASE
FILQSALNDLWSIKPDTVQVIRT-QNPQSYVYMVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-NKITRSTDTQFTYNFAYGN-NWTYTCIDLLDLVRTK
YTGTNISLQRISLHKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGKSKI
RIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLEGMGRISVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHVLGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSNIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCSLLSVD-E-KELKCQILNGSAGHAPVAVSMA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITVRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAY----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1761)

PSISNITPSSGTVNELITIIGHGFSNLPCANKV-TIGSYPCVIEESSE
DSITCHIDPQNSMDVGIRET

ENSGT00780000121902_0_Linker_9_10 (1761, 1787)

VTLTVYNLGIAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVP
AQCQENCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1951)

PYITGVFPNSII-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSVSVVVGSKGL

ENSGT00780000121902_0_Linker_11_12 (1951, 1962)

ALGKLTVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAMSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVVGSGFSENIEDVHVTIAEAKCDVEYSNKTHIICM
TDAHTLSGWAPVCVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKMTIASVSPDGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPAPAIFNSFTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDTRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKERPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVILNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKLSETALAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLPVATEDDF
YTSHNLVKNLALFLKIPSDKIRISK-IRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVGV-
----ESRTFSLLAESVSSSGSSSSSS---------------------SSSASTVGTYAQI
MTVVISCLIGRMWVLEIFMAAVSTLNITLSKYSPL---IHYFSTC---------------
-------------

MVVSKMNKDA

PF10163 // ENSGT00780000121902_0_Domain_0 (11, 71)

QMRAAINQKLIETGERERLKE-LLRAKLIE---CGW----------KDQL
KAHCK-----

ENSGT00780000121902_0_Linker_0_1 (71, 77)

DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKITEIIPKYGSINGATRLTIKGEGFAQANQFDYGVGNAELGNR
VQLISSFRSISCDVEKDSSHSTHITCYTRAMPEDSYTVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVTENNTCKGHVSSR
ACIFSA-------KIFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPSSGTPGTLITIRGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLISQSDNLYGLKLDHPNGDMGSMVCKMSGTYIG--HHNVSFILD-S
DYGRSLPEKTA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 427)

EITRISPS
QGSTQGGTLLT-ISGRFFDQTDFPVRVLVGGQA----CHILNVTENSICCKTPP-EPD-I
LRTIYP

ENSGT00780000121902_0_Linker_3_4 (427, 429)

GG

PF07691 // ENSGT00780000121902_0_Domain_4 (429, 557)

RGLKLEVWNNSRPVRLEEILEYSEKTPGYMGAIWVDSASYVWPMEQDTFVAR
FSGFLVAPESDVYRFYIKGDDRYAIYFSQTGLPED--KVRIAYHSSNANNYFSSPTQRSD
DIHLQKGKEYYIEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFVDVGLYQYKSVYTEQQTEDAVNEEQVIKSQSAVVQE
VQVITLENWETTRATNEVQKVMVTSPCVEANLCSLYQYRLIYNMEKT----VWLPADASE
FILQSALNDLWSIKPDTVQVIRI-QDPRSYVYLITFISTRGDFDLLSYEAFEGNNVTLAI
TEQTKGKPSLDTFTLSWDGITSRPLTPQSSVAEFQAAVEEMVSSKCPPQIATFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKQNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDT-SKIARSTDTQFPFKFAYGN-NWTYTCIDLLDLIQTK
YTGTSFSLQRISLQKASESQSFYVDIVYIGQTSTMTTLDEMSKRRLPALANKGIFLKDFQ
VNQTKSNGSSITNQYSVTMTSYNCSYNIPMMAVSFGQRITNETENESVYRGNNWPGESKI
RIQRIQAASPPLRGSFDIHAYGHVLT-GIPAAVSATDLQFALQSLEEVGQVSVTREGGCA
GYSWRVKWRSTCGKQPLLQINDSNIFGENANM--TVTKIKEGGLFRQHVPGDLLRTPSKQ
PQVEVYVNEIPAKCSGNCGFTWEPTTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PQIRAINPSQGSYEESTILTISGSGFSPSS---
SVSVSVGPAGCSLLSL--SENEIKCQILNGSAGRFPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGRARNVEE-KGFHFTY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1336)

QISHIWPASGSLA-GGTLLTVSGFGFHEYSKVLVGNETCSVIEGDLNKITCRTPKSIE
GTVDISVITSGVQAT

ENSGT00780000121902_0_Linker_6_7 (1336, 1348)

AKNAYSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITDFSPKVRTI-----LGEVNLMIKGYNFGN
ELTQNMEVYVGGVSCQVLHRNFTDI-RCLLPKL-------SPGKHDICVEVRNWGF

ENSGT00780000121902_0_Linker_7_8 (1437, 1453)

ASTR
-DKSSASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTNMFPQKGSLYGGTE-ITIMGLGFSTIPTENTVLLGSFPCNVTSSS
ETVIKCVL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNVFRITNNGEDSVHGLGYAWSPSVLNVSVGDTVTWLWRAHPYLRGIGY
SVFSVSSPGSVIYDGKGFTNGREKSASGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETSHIPLHLFVGGTEATYAQ----GRPVSLHLGSSVAGCQAREPLCGLNSTRAENS
ERLLFELSSCLS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1767)

PSISHISPSIGTLNELITITGRGFSNLTCANKV-KIGSYPCVVEESSN
NSLVCRIDPQNSMDVGIREIVTVTVY

ENSGT00780000121902_0_Linker_9_10 (1767, 1787)

NLGTAINTLSSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMISPNAGSTT
GMTKVTIKGSGFAVSSAGAQVLMGHFPCKVLSVNYTAIECETSPAPQQLVKVNLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1879)

YLESIAVF

PF01833 // ENSGT00780000121902_0_Domain_11 (1879, 1951)

VTRIFPNSLQ-GSEKVLIEGEGFGTALEDISVFTGNQQFRAV
DVNENNITVLMTPLPAGLHSLRVVVGTKGL

ENSGT00780000121902_0_Linker_11_12 (1951, 1960)

ALGNLTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2029)

PAVASVTPTSGSIGGGTTLMV
TGNGFSPGNTTVTVGDEPCQILSVNSSDIHCRTPAGTAGRVSVKVSVN

ENSGT00780000121902_0_Linker_12_13 (2029, 2045)

AVAYPPLSFMYA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2121)

PLLKGIVPST-GPPETEIQVTGSNFGTDILEISVMISSTQCNVTKVNDTVLQCIVG
DHAGGTFPVTMHHKTKGFAM

ENSGT00780000121902_0_Linker_13_14 (2121, 2130)

STVVFKYPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIDSIHPSQG-SFGGDQTMTVTGTGFNPQNS
VVLVCGSKCAVDKLKSNHTTLLCDIPPSNG-RGPEQACEVSV---VNGKDSSQSTATFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
NMSMT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PFITKIAPKRGSTAGGTRLTVLGSGFSENVEDVLVTVAEATCDVEYSNKTCIICM
TNAHSPSGWAPVHVSIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2319)

STGLAKRANADFLYVDTWSSN

PF10162 // ENSGT00780000121902_0_Domain_16 (2319, 2438)

SSWGGKSPPEEGSLVVITKGQI
ILLDQNTPILKMLLIQGGTLIFHEADIELQAENILITDGGILQIGTEAAPFQHRAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTRLAHTAKAGERTLILQEAVTWKPGD
KIVIASTGHRHSQRENEERTIASVSADGRNITLTDPLNYTHLGITVTLPDGTLFEARAEI
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHA
PLAGANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCAIHQTYNRAITI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVHQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSSVPVPAVFHSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNGKIVGHLDELGMGSAFCTTKGLVLPFNEGLTVSSVHFMN
FDRPSCAALGVTSITGVCNHRCGGWSAKFAGIQYSHTPNKAGFRWEHEVVLIDVDGSLTG
HKGHTVIPHSPLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGKNDLHQSQSI
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNN

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSRENN
YTIPYPGANVVIPEGTWIVADTDIPPMARLVIRGVLELEDK-HNVGAAESSYRKVVLNAT
YISLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
HSIYKTKLSETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDTLSYTHFAERYHVPGTSQSYTLAADVGILSRNIKILGEDYPGWLKESFGARVLVSS
FTENMVTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQERGSSYVQGCAFH
NAFSPAIGVFGTDGLDIDDNVIHFTVGEGIR-IWGN-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSGQSHSLEKWFDNEAHGGLF
GIYMNQDGLPGCLLI-----QGFTIWSCWDYGIYFQ----------------TTESVHIY
NVTLIDNGMAIFSMIYMPSAVSHKISSKTVQIKNSLIVGSSPEFNCSDVLTNDDPNIELS
AAHRSSRPP--------------------S--GGRSGICWPTFSSAHNMAPRKPHAGIMS
YNSISGLLDISD--TTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDLSKVNPSDCVDMVCDAKRKSLLRDMDGSFLGDSGSVIPEAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDSTCKYIPEWQGHQCFGMEYAMMVIESLDS
DTETRRVSPVAIVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALGKSYEVYFTG
TSPQNLRLMLLNVDHDKAVLVGIFFPTRQRLDVYVNNTLVCPENTEWNSQQKYCEPA--R
QLYTDQLLPNLNSTVLGENYFDRTYQMLYLLVKGTIPVEVHTAAVIYVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSKVIRGESLR--RKRSM-GLTVELEIGDPRPRFITKD
TAGQ--MQLP-ELQEI--ADSLGQAVILGKTNSILGFNVSSMSITDPIHSPNDSGWAKVA
AQPVGRLS--FPVHHVAFVTSLSVITQPVATQLGQPFSQQPSIKAEDADGNCVSVGITAL
ALKAVLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGKNFKIEFILDEFIWV-
----ESQPLSLASQSVSSPGSSSGG--------------------SSNSKASTVGTAAQI
VTTVISCLVGRVLLLEMFMTAVLTLNIL--------------------------------
-------------

----------------------------MGH-LW--LAAL---WGLWAL-------LLSA
ADPRT-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSVNGATRLTIKGEGFSQANQFNYGVDNAELGNS
VQLVSSLRSITCDVEKDSSHSTQITCYTRAMPEDSYAVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVAENNTCKGHINSW
ACSFNV-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PIIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYAGGMPCELLKPQSDDLYGLKLDHANGDLGSMICKVTGTYIG--HHNVSFILD-S
DYGRSFPQKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNTI-SMFQTF-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 439)

EVTTISPS
KGSIQGGTMLT-ITGRFFDQTDLPASVLVGGQP----CDILKVTESSICCKTPP-RPD-I
LKTVYPGGRGLRLEVWNG

ENSGT00780000121902_0_Linker_3_4 (439, 454)

SQPARLEDILGFDET

PF07691 // ENSGT00780000121902_0_Domain_4 (454, 558)

TPGYMGAAWVDSASYSWPMEHDTFVAR
FSGFLVAPDSDVYRFHIRGDDRYAIYFSQTGLPE--DKVKIAYHSTNANSYFSSPTQRSD
DVHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQRRTVYTEEQTGDAISEEQLIKSQSTVIQE
VQVITLENWETTIPTNEVQKITVTSPCVAANSCSRYQYRLIYNMEKT----GLLPADASE
VILQSALNDLWSIKPDTVRVVRT-QDFQSYIYTVTFISTRGDFDLLSYEVFEGNNVTVDV
VEQTKGKPSLETFTLNWDGVLSKPLTPWSSEAEFQVAMEEMVSTKCSPQIAHFEEGFVVK
YFRDYETDFNLENVNRGQKTAESGAYCGRYSLKNPSVLFDSADAKPNRLPYGDILLFPYN
QLCLAYKGFLANYISLKFQYQDN-GKITRSTEKQFMYNFAQGN-SWTYTCLDLLDLIQSK
QTGTNFSLQRISLQKATEKQSFYVDVLYIGQVSTTSTLDEMAKRRLPALANKGIFLKHFQ
VNESKRDESSMTIQYSVTMMSYNCSHNIPKLAVSFGQIIASETENESVYRGSNWPGESKI
RIQRIQAASPPISGSFDIQAHGRVLK-GIPAAASAAEVQFALQSLEEVGRVTVTREGTCA
GYSWGITWRSVCGRQNLLQINDSKIIGEKANV--TVTKIKEGGLFRQHILGDLLRTPHQQ
PQVEVYINGIPAKCSGDCSFTWDPTAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1256)

PQILAISPSQGSYEESTILTIVGSGFSPSS---
AVSVSVGPTDCSLLSVE-E-NEIKCQILHGSAGRLPVAVSVADTGLAQSTES-QG

ENSGT00780000121902_0_Linker_5_6 (1256, 1264)

FHFVY
QSQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1340)

IAHIWPDSGSLA-GGTLLTLSGFGFSENSTVLVENETCNVIEGNLSRIICRTPKRSE
GTIDVSVITNGFQATARNV

ENSGT00780000121902_0_Linker_6_7 (1340, 1348)

FRYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVITDFSPKIRKI-----LGDVNFTIKGYNFGN
ELTQNIKVYVGGKSCQILHWNLTDI-RCLLPLL-------SPGKHSFYVEVGNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1453)

FAST-
SDKLNASVQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1508)

EVTGMFPHRGSLYGGTE-IIITGAGFSTVPTENSVLLGSFPCNVTSSS
ESIIKCT

ENSGT00780000121902_0_Linker_8_9 (1508, 1693)

LCSTGNVFRITNDGDDLVHGLGYAWSPSVLNVSVGDTVIWQWRSHPLLRGVGY
RVFSVPSPGSASYNGEGFTNGRQKSLSGSFSYQFTSPGIHYYSSGYVDEAHSVSLQGVIN
VLPAETRHLPLHLFVGSTEATYAQ----GGPENLHLGSPVASCLATEPLCGVDDTKVKHS
NAFLFELSRCVS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISSITPSAGTVNELITITGSGFSNLTCANKV-TIGHYPCVVEESSA
NSIMCRVDPQNSMQVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IRESVTLVVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNINMVWPNAGSTT
GMTRVTILGSGFAVSSAGVEVFMGHFPCKVLTVNYTTIECETSPAPQQLVNVQLLTHGVP
GLCQGSCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PSITGISPSTIT-EPAKVFIEGEGLGTTVEDIAVFIENQQLRPV
DVNENNMTVLVSSLPAGLHPVRVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PMIASVSPTSGSLGGGTTLVI
IGNGFLLDNTMVRVGEGPCQIMLANSSEVHCSTPAGGAGKVDLQILVNGAPYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
VEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGITPNT-GPPGTEIEITGSNFGTAISEISVMISGTACNVTMVNDSVLRCALG
DHAGGIFPVALLHKTKGFAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQNLHPQQG-SFGGGQILTVTGAGFNPQDS
VILICSSKCAIDRLRSDHTTLFCETPPSEG-VGPDQACEVSV---VNGRDSSWSTTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
KMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLVTEISPTRGSTAGGTRLSVLGSGFSENPQDVHITIAEAKCDVEYSNKTYIICV
TNAHSPSGWASVHVNIRNIGLAKMENTD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKPPPEEGSLAVITKGQI
LLLDQSTPVLKVLLIQGGTLIFDEADIELQAENILITDGGILQVGTEAAPFRHRAVITLH
GHPRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTQLARTAEAGTRTLILHDAVTWKAGD
SIVIASTGHRHSQRENEKRTIASVSADGVNITLTQPLNYTHLGITITLPDGTAFEARAEV
GVLTRNIIIRGSENVDWNNKIPACPKGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PLPSANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQSYNRAVTI
HNTHHLLVEKNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMKTGSCTSTVPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMINNYEAGIET
KRILAPYVGGWGETNGAVVKNAKIVGHLDDLGMGSAFCTSKGLVLPFSEGLTVSSVQFMN
FDRPNCVALGVTSITGVCHDKCGGWSAKFIDIQYFHTPNKAGFRWEHEAVLIDIDGSLTG
RTGHTVIPHSSLLDPSHCVQEAQWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHTSGWMALIPNANHINWYFRDMEHITNISYTSTFYGFKEEDYVI
VSHNFTQSPDMFSVVDTRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRRD-HQSQSI
SGTLDPDVKDVVINFQAYCCILQDCFPVHPPSRRPSPRKRPATYMYVGLL----------
------------------------------------------------------------
-------------------------------------------------------YHGFP
VT-------------SQEDHFCITRHWREGEEIVITTTSYDIHQTETRSIVKVLHGRRIL
ILNDSLSYSHFAKRYYVPETDQSYTLAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGS
FTGNMITFRGNAR-ISNVEFYHSGQEGFRDSTDPRHAVTFLNLGQTQERGSSYVRGCSFH
HGFSPAIGVFGTDGLDIDDNVVHFTVGEGIR-IWGD-ANRVRRNLVAFSVWPGTYQNRKD
LTSTLWHAAIEVNRGTNTVLQNNVVAGFGRAGYRIDGEPCLSQANPVESWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------ISERVHIY
NVTLVDNGMAIFSMIYMPAAVSHKISSKTV--KSSLIIGSSPEFNCSDVLSEDDPNVELT
GAHRSVR----------------------PPAGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGSLDVSD--TTFVGFKNVCSGETNVIFITNPLNEDLQHPIYVRNIQLVDTTESSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDMDGSFLGRSGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDATCKYIPDWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHSKGVLVGIFYSTLQRLDVYVNNSLVCPKNTVWNAQQKHCKLN--R
HLYAEQFLPKLNSTILGENYFDRTYQMLYLLVRGTTPVEIHTAAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSKITRGRSLR--RKRSP-GNSVELEIGDPPARSLSND
TTGR--MKLS-ELQEI--SGSLGQAVILGKISSILGFNISSMSITNPIPSPNDSGWIKVA
AQPVTRSA--FPVHHVAPVSSLSVVTQPVAAQLGQPFSQQPSIKAVDPDGNCVSVGITSL
TLKAILKDSSNNQVSGLSGNVTIPFSSCWANYTDL---TPLRVGKNYKLEFILDNVAQA-
----ESRAFSVSVQSVSGGGGSSSS-----------------------SGASAVGASGWI
VAVLTSCLMGRMLMLEVFMTAAFILNIDVGEYIHS---ACDARLS--------TYSGAC-
-------------

----------------------------MGH-LW--LLGT---WFLWGK-------LLCA
ADPRT-----D--AEI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 171)

PRVTEVLPKYGSINGATRLTVKGKGFSQVSQFNYGVDNAELGNR
VQLVSSFRSITCDVEKDSSHSTQIICYTRAMPEDSYTVRVSVDGVPVTEN

ENSGT00780000121902_0_Linker_1_2 (171, 199)

NTCKGLTSSR
ACSFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-KNV
RILRVYAGGMPCELLMPQSDDLYGLKLDHPNGDLGSMTCKITGTYVG--HHNVSFILD-S
DYGRSFPEKIT-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 426)

EVTMISPS
KGSIQGGTTLT-ISGRFFDQTDLPARVLVGGQA----CDILDVTENSIHCKTPP-KPQ-I
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 430)

PGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKLEMWNNSRPAHLEEILHYNEHTPGYMGASWVDSTFYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIRGDDHYALYFSQTGHPE--DKVRIAYHSANANSYFSNPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1169)

EYRLSAFVDVGLYQYRNVFTENQTGDAVNEEQVVKSQSTVMPE
VQVITLENWETTNATNEVQQITVSSPCVGANSCSLYQFRLTYNMEKT----VWLPADASD
FRLQSALNDLWSIKPDTVQVTST-RNAQSYIYTITFVSTRGDFDLLGYEVFEGNNVTLDI
TEQTRGKPNLETFTLSWDGIASKPLAAQSSEAEFQMAVEEMVSTKCPPEIAHLKEGFLVK
YFRDYETDFDLENVNRGEKTAETDAYCGRYSLKNPAVLFDSADVKPNKLPYGDILLFPYN
QLCLAYKGSLANYIGLKFKYQDN-GKITRSADTRFEYNFAYGN-EWTYTCIDLLDFLQTK
YAGTSFSLQRISFQKSLEAQSFYVDVVYIGQTSTISALGEMPRRRFPALANKGIFFKHFQ
VNQTKLNVSTMTIQYSVIMTSYNCSYNIPMMAVRFGQIIANETQNESVYRGNNWPGESKI
RVQRIQEASPPISGSFDLQAYGHILK-GIPAAVSASDLKFSLQSLQEIGQVSVNREGTCA
GYSWSIKWRNPCGKQSLLQVNDSNIIGEKASV--TVTKIKEGGLFRQHLLGDLLRTPNQH
PQVEVYVNGIPAKCSGDCGFTWDPMTTP

PF01833 // ENSGT00780000121902_0_Domain_5 (1169, 1243)

LVLTTSPSEGSYEENTVLTIAGSGFSSTS---
AVSISVGPTSCSLLSVD-E-NEIKCQILNGSAGHVPVVVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVEG-EGFHFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHISPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCKMIEGDLTRITCKTPKRIE
GTVDILVITNGIQATAKDSFT

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITDFSPKVRTI-----LGDVNLTIKGYNFGN
ELTQNM-VYVGEKTCQVLHSNFTDI-RCLLPML-------SPGKHDIYVEVKNWGF

ENSGT00780000121902_0_Linker_7_8 (1437, 1454)

AST-
RNKLNASIQYILE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHMFPQRGSLYGGTE-ITIMGLGFSTTPTENSVLLGSFPCNVTSSS
ENIIKCTLQ

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNVFRITNSGSHLEHGLGYAWSPPVLDVSVGDTVIWHWQAHPFLKGIGY
RVFSVSSPGSVIYDDKGFINGRQKSSSGSFSYQFTSPGIHYYSSGYVDEAHAISLQGVIN
VLPVETRHIPLQLYVGNTEAIYAP----AGPENLHLESSVAGCLATESLCGLNDTKVNNS
TKLLFELSSCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PSISNITPSIGTVNELITITGHGFSNLTCANKV-TIGSYPCVVQESNN
SSIICHIDPQNSMDVGIRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVSLIVYNLGTAINTLSSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPSTGSTT
GMTRVTIQGSGFVVSSAGVEVLMGNFPCKVLTVTYSAIECETSPAPQQLVPVELLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1955)

PYVREIFPNSIK-GSVKVLIEGEGFGTVLEDISVFIGSQQFRAI
DVNENNITVLMTPLPAGRHSLSVVVETKGLALGN

ENSGT00780000121902_0_Linker_11_12 (1955, 1960)

LTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAIASVAPISGSIAGGTTLVI
TGNGFSPHNTTVTVGDDPCQIMFINSSEVYCSTPAGRAGMANLKISVNAVTYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
QKDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKRIIPNR-GPQGTEVEITGFNLGFDISEVSVMINDSACNVTTVNDSVLQCIVG
DHAGGIFPVAMFHKTKGSALSSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

YIQNIHPRQG-SFGGGQTLTVTGAGFNPQNS
IILVCGSECAVDRFVSDSTTLFCEVPPNKG-RGPEQACEVSV---VNGRDSSRSTALFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PFITEISPKRGSTTGGTRLTVRGSGFSENTQDVHITIATDKCDVQYSNKTHIICM
TSAHTPSGRAPVHLSIRNIGLAKSENADFL

ENSGT00780000121902_0_Linker_15_16 (2311, 2321)

YIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKAPPEEGSLAVITKGQT
VLLDQSTPVLKMLLIQGGTLIFDEADIELQAENILITDGGILQVGTEASPFQHKATITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPIPVVWTRLAHTTKAGERTLIVQEAVTWKAGD
IIVITSTGHRHSQQENEKKIIASVSANGINIILTSPLKYTHLGITVTLPDGSTFEARAEV
GILTRNIVIRGSDNVKWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PFPGTNLVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNVIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSYDRNICQKRISLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPTPAVFDSLIVWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYIGGWGETNGAVIKNAKIVGHLDELGMGSEFCTSKGLVLPFSQGLTVSSVYFMN
FDRHDCVALGVTSISGVCNDRCGGWSTKFVDIWYFHTPNKAGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSVGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVILS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDVDHLTNVSYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRSDLHDSQPI
SGALDPDVKDVVINFQAYCCTLQDCFPVHPTSRKPIPRRRPAAYILWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVVIPEGTWIVADTDMPPMERLIIWGVLELEDK-SEVGDGESSHRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIILRGNHSTPEWPLPEGPNQGAKVLGVFGELDLHGLP
RSIYKTKLAETAEAGSKVLSLMVAVDWQEGEEIVITTTSYDLYQTEARRIVKILHGHTIL
ILNDSLSYTHLAERHQIPGTGQSYTLAADVGILSRNIKIVSEDYPGWSKDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYSVTFLNLGQSQERGLSYVRGCAFH
QGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNIVAGFGRVGYRIDGEPCSSQSNPMENWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFIIWTCWDYGIYFQ----------------TSESVHIY
NVTLVNNGMGIFSMVYMPAAVSHKISSKTVQIKNSLIVGSSPEFNCSDVLTNDDPDVELT
AAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLNVSG--STFAGFKNVCSGETNVIFITNPLNEDLQHPIHVKNVQLVDTTEQSK
IFIHRPDVSKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYQCSGMEYAMMVIESLDS
DSETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKLYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFATLQRLDVYVNNALVCPKNTAWNAQKKHCEPN--R
HPYTGQFLPNLGSGIPGENYFDRTYQMLYLLVKGTTPVEVHTATVIFISFQLPALTENDF
YSSHNLVRNLALFLKIPSDKIRVSRIMGGESLR--QKRST-EHTTELEIGDPPTQLLSNS
TTGQ--MQLS-ELQEI--AGSLGQAVILGKISSILGFNISSMSITSPIPQPTDSGWIKVT
AQPVDRST--FPVDYVALVSSLSVIAQPVAGQPGQPFSQQPSVKAVDSEGNCVSVGITSL
TLKAILKDSNNNQVGGLSGNTTIPFTSCWANYTDL---TPHRTGKNYKIEFLLDNAIQV-
----ESKTFSLSVQSVPGGGGGGTGAGG--------------SSSSGLSKASSVCSSVQI
LAVVTGCLIGRMLLLEIFMAAVFTLSTPGNN-----------------------------
-------------

----------------------------MGH-LW--LLGT---WGLWGL-------LLCA
ADPRT-----GDSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 175)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVEDAELGSS
VQLVSSFRSFSCDVERDASHSTQITCYTRAMPEDSYTVRVSVDGVPITENNTCQGHIRSR
ACSFYV-------KSFKTPTIRSITPLSGTPXXXXXXXXKIFTDVYGSNTALSSNSVKNV
RILRVYIGGMPCELLIPQSDNLYGLKLDDPSGDLGSMICKTTGTYIGKCHHNVSFILD-S
DYGRSFPQKMA-YFISSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 470)

AEVTAIA-S
RGSIQGGTMIT-ISGRFFDQTDFPVRVLVGGQA----CDVLNVTENSICCKTPP-KPI-F
GT-VSANEK-----------------------------------LLLFYYVVGEXXXVAR
FSGFLVAPD-DVYRFYIKRDDRYAIYFSPTGLPED--KVKIAYHSSNANSYFSSPTQRSD
DIPLQKGKEYYIEILLQEYRLSAFVDVGLYQYKNVYSEQQTEDAINEEQVIQSQSTVVQE
IQVITLENWETTNATKEVQKVTVTSPCIEVNSCSLHQYRLIYDREKT----VWLPADASD
VILQSALNDLWSLKPDSVQVIRT-KKPQSYVYMITFLSTRGDFNMLGYEVFEGHNVTLDI
TEQTKGKPSLDTFTLNWGGIMSKPLIPWSSEAEFQAAVEEMVSAKCPQQIANFEEGYVVK
YFRDYETDFNLEDINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNQLSYGDILLFSYN
QXXXXXXXXXXXXXGLKFKYQDK-SKITRSTDIQFTYNFVYGN-XXXXXXXXXXXXXXXX
XXGTNFSLQRISLQQASRSQSFYVDIVYIGQTSTMSILDEMPKRRLPALANKGIFLKHFQ
VNRTKINGSSMTNQYSVTMTSYNCSYNIPMMAVSFGQIITNEIENESVYRGNNWPGESKI
RIRRIQAASPPLSGSFDVQAYGHSLK-GLPAAVSATDLQFALQSLGEVGRVSVTREGTCA
GFSWNIKWRSSCGKQNLLQVNDSNIIGEKANM--TVTKVKEGGLFRQHILGDLLRTPTQQ
PQXXXXXXXXXXXXXXXXXXXXXXXXX

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1255)

XXXXXXXXXXXSYEESTILTILGSGFSPSS---
AVSVSVGSIGCSLLSV--DENEIKCQILKGSAGCLPVAVSVDDVGLAQNVED-E

ENSGT00780000121902_0_Linker_5_6 (1255, 1262)

IFCFVY
Q

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

NQISHIRPASGSLA-GGTLLTLSGFGFHENSKILVGNETCSMIDGDLNKITCRTPKRTE
GTVDISVITNGFQATAKDAYSYNCLQTPVITDFSPKVRTI--------------------
------------------------------------------------------------
LDKLNASIRYV

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVTNMFPQRGSLYGGTE-ITIMGLGFSTIPAENTVLFGSFPCNVTSSS
VNVIKCILHSTRNVFRITNDGEDPVHGLGYAWSPSVLNVSVGDTVNWHWRAHPFLKGIGY
RVFSVFSPGSVIYDGKGFTNGREKSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLSVGGTEATYAQ----GVPVNLHLESSVAGCLATKPLCGLNDTGVKNA
DRLLFELSGCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1777)

PSISNISPSTGTVNELITITGNGFSTLTCANKV-TIGSYPCLVEESSI
DSIVCHIDPQNSMDVGIREIVTLTVYNLGTAINTLS

ENSGT00780000121902_0_Linker_9_10 (1777, 1787)

NEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNINMVLPNAGSTT
GMTKVTIKGSGFTVSSAGVEVLMGRFPCKILSMNYTAIECETSPAPQQLVKVDLRIHGVP
AWCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

TVVTRIFPNSLS-GSVKVLVEGEGFGTVLEDIAVFIGSQRFQAI
DVNENNITVLVTPLPAGLHPVSVVVGTKGLALGNHT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVTPTSGSIGGGTTLVI
TGNGFYPSNTTVTIGDEPCQIISVNFSEVYCYTPARTAGRVSVKIFVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
WEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLKGIVPNT-GPPGTRIQITGSNFGIDILEISVMINNIQCNVTMVNASVLQCITG
DHAGGTFPVMMHHKTKGSAVSTVVFK

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTIQNIHPNQG-SFGGGQTMTVTGTGFNPQNS
TILVCGSECAVDRLKSDRTTLLCKIPPNNG-EGPEQACDVSV---VNGKDLSQSETPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

SLITEISPKRGSTAGGTRLTIMGSGFSENMQDVLVTIAEAKCDVEYSNKTYIICM
TNACTPSGWAPVHVTVGSIGMARQNNADFFYVDTWSSNFSWGGKSPPEEGSLVVIAKGQR
ILLDQNTPILKMLLIQGGMLIFDEADIELQAENILITDGGILQIGTEASPFRHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTRLAHTAWAGEMTLILQEAVTWKPGD
KIVIASTGHRHSQQENEKRSIASVSADGINITLSNPLNYTHLRITVTLPDGTLFEARAEV
GILTRN-LIRGSDNAEWNNKIPAC-EGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCISTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMINNYEA-IET
KRILAPYVGGWGETNGAMIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEVVLIDVDGSLTG
HQGHTVVPHSSLLDPSHCTQEAEWSMGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLDQSQPI
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPPSRNPVPRKRPATYNLWSNDSFWQSSRENN
YTIPHPGANVVIPQGTWIVADTDIPPMERLVIWGVLELEDK-HNVEATESSYRKIVLNAT
YISLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETAEAGSKVLSLMDAVDWQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXERYYVLETGQSYTLAADVGILTRNIKILGEEYPGWFKESFGARVLVSS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDVDDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
SSSTLWHAAIEINRGTNTILQNNVVAGFGRAGYCIDGEPCSGQSNSLERWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVQIY
NVTLVDNGMAISSMIYMPAAVSHKISSKTVQIKNSLIVGSSPEFNCSDVLTNDDLNIKLS
AAHRSSRPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLEISGKYSTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKDIQLVDTTEQAK
IFIHRPDISKVNPSDCVDMVCDAKRKSLLRDMDGSFLGNSGSVIPQSEYEWNGNSQFGIG
DYRIPKVMLTYPNGTRIPITEKAPYKGIIRDSTCKYIPEWQSYRCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALNKPYEVYFTG
TSPQNLRLMLLNIDHNKAILVGIFFSTLQRLDVYVNNALVCPKNTVWNPEQKYCEFN--Q
HLYTEQFLPNLNSMVLGENYFDRTYQMLYLLVKGTVPVEIHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALYLKIPNDKIRVSKIIRGESLR--RKRSL-GLTVELEIGDPPSQFISRN
TAGQ--MQLS-ELQEI--AASLGQAVILGKTGSIFGLNISSMSITNPIPSPSDSGWIKVT
AQPVERFA--FPVHHVAFVFSLSVITQPVAAQLGQPFSQQPSVKAVDSDGNCVSVGITWL
TLKAILKDANNNHISGLGGNTTIPFSSCWANYTDL---ALLRTGLNYKIEFMLDNVARV-
----ESRTFGLPAQSVSSSSGSGGS------------------SGSSNSKASTVGTVAQM
TTIVTSCLVGRMLLLEIFMAAVLTLNVSLRST----------------------------
-------------

----------------------------MGH-LW--LSGT---WFLLGL-------FRCA
ADASK-----DGSETI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 168)

PKVTEVIPKYGSINGATRLTIKGEGFSQANQFNYGADNTELGNH
VQLVSSFRSITCDVEKDSSHSTQITCYTRAMPEDTYTVRVSVNGVPI

ENSGT00780000121902_0_Linker_1_2 (168, 199)

AENNTCRGLASSR
ACSFSA-------KGFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLAGTPGTLITIQGRLFTDVYGSNIALSSNG-RNV
RILRTYIGGMPCELLLPHSDDLYGLKLDHPSGDTGSVTCKTTGTYIG--HHNVSFILD-S
DYGRSFPEKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNKI-SMFQTY-----------------------AE

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 421)

VTIISPS
KGSTQGGTVLT-IHGRFFDQTDLPVRVLIGGQA----CDILNVTENSIHCKTPP-KPT-S

ENSGT00780000121902_0_Linker_3_4 (421, 471)

LKTLYPGGRGLKMEVWNNSRPVHLEEILEYNEHTPGYLGASWIDSASYVW

PF07691 // ENSGT00780000121902_0_Domain_4 (471, 558)

PMEQDTFVAR
ISGFLVPPDSDVYRFYIKGDDRYAIYFSLTGHPE--DKVKIAYHSANANSYFSSSTQKSD
EIHLQKGKAYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYKNVFTEQQTGDAVNEEQVIKSRSTVILE
VQIITLENWETANATNEVQQVAVTSPCVGTNSCARSQYRFIYNKEKT----VWLPADASD
FMLQSALNDLWSIKPDSVQVTSK-RDHQTFIYTITFVSTRGDFDLLGYEVFEGNNVTLDI
TEQTRGKPDLETFTLTWDGIASKPLAPESSEAEFQAAVEEMVSAKCPPEISHLEEGYLVK
YFRDYETDFELDHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNKLPYGDILLFPHN
QFCFAYKGSLANHIGLKFKYQDS-GKIFRSADMQFEYDFSSGN-KWTYTCIDLLDFLQTK
YVGTSFSLQRISLQKSSECQSVYVDAVYIGQTPTVSALGEMPKRRPPALANKGIFLKHFQ
VNKTKINGSTTAIQYSVTMTSYNCSHNIPMMAVSFGQAITNETKNESVYRGNNWPGESKI
RIQKIREASPPISGSFDIHTYGHTLK-GIPAAVSASDLQFALQSLEETGQVSVTREGTCA
GYSWAIQWKSPRGKQPLLQINDSNITGEEANV--SVTTIKEGGLFRHHILGDMLRTPNQQ
PQVEVYVNGIPAKCSGDCGFTWDPMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PIVLTVTPSEGSYAESTILTIAGSGFSPPS---
AVTVSVGSTSCSLLSVD-E-NEIQCQILNGSAGHVPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNLDD-EGSHFVY
RS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCNVIEGDLNRITCRTSKRIE
GTVDISVITNGIQATAKDSFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITDFSPKERAI-----LGNINLTIKGYNFGN
ELAQNM-VHVGGKACQVLHSNFTDI-TCLLPKL-------PPGKHDIHVKVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1457)

AST-
RNKLNASIRYILEVIH

PF01833 // ENSGT00780000121902_0_Domain_8 (1457, 1510)

MSPHRGSLYGGTE-LTIMGLGFSPIPTENSVLLGSFPCNITSSS
ENVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFNITNNGSHLEHGLGYAWSPPVLNVTVGDTVVWHWRAQPFLRSVGY
RVFSISSPGSVTYDGKGFTNGKQKSASGSFSYQFTSPGIHYYSSGYVDETHSISLQGVIN
VLPAESRHVPLRVFVGNTEAMHAA----AGPENSYLASTAAGCLATEPLCGLNDTRVRNT
DQLLFEFSHCVS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSTGTVNELITISGHGFSLLACANKV-TVGSHPCVVEESSE
NSIRCRIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLTVYNLGAAINTVPSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPSAGSTT
GMTRVTIHGSGFVASSASVDVSMGDFPCKVLTVTYTAVECETSPASQQLLPVDLVIHGVP
SQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENLA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYVTGLFPNSIE-GPGNLLIEGEGFGTLLEDVSVFIGSQQLRAI
EVNENNITVSMTPLPAGLHSLHVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTTGSIAGGTTLVI
TGNGFAPGNTTVTVGNNPCQIVFTNSSEVYCSSPAGRAGTASLKISVNAIVYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKRIIPNR-GPPGTEVEITGSNLGFDISDVSVMITDTACNVTAINDTVLQCIVG
EHAGGVFPVTMLHKTKGSALSSVEFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

YIQNIYPRQG-SFGGGQTMTVTGAGFDPQNS
AVLVCGYTCAIDRLGSDSTTLLCETPPNNG-NGPEQACGVSV---INGKDSTQSTMPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2300)

PLIAEISPRRGSTAGGTRLTVTGSGFSENTQDVHVSIARDKCDVQHSNRTHIICM
TRTHAPSGWSPVHVSIRNV

ENSGT00780000121902_0_Linker_15_16 (2300, 2321)

GMAKLENADFLYVDAWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGNPPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTANAGEWTLIVQEAVTWKAGE
SIVIASTGHRHSQGENEKRTIASVSSDGMSITLTRPLNYTHLGITVTLPDGTVFEARAEV
GLLTRNILIRGSENVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHA
PLPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSYDRNICQKRIPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFNSLTVWNCQKGAEWVHGGALQFHNFLTVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTSKGLVLPFSQGLTVSSVHFMN
FDRRDCVALGITSITGVCNDRCGGWSTKFVDIQYFHTPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCAQEAAWSIGFPGSVCDASVSFHRVAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFRGVEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVVDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRSDLPQSQPI
PGTLDPDVKDVIINFTAYCCVLQDCFPVHPPSRKPVPRKRPTAYILWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSPENN
YTVPHPGANVVIPEGSWIVADTDIPPMEKLIIWGVLEIEDR-SEVESAAPSYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGLP
HSIYKTKLSETAEAGSRILSLVDAVDWQEGDDIVITTTSYDLHQTETRRIAKILHGHKIL
VLNDSLSYTHLAERQQIPGTGQGYTLAADVGILSRNIKIVGEDYPVWSRESFGARILVGS
FTGHMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQTEEHGLSYVRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNVVAGFGRAGYRIDGEPCSNQANPMENWFDNEAHGGFY
GIYMNEDGLPGCSLI-----QGFTVWSCWDYGIYFQ----------------TTESVRIY
NVTLVNNGMAIFPMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLSNDNPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDVSG--STFVGFKDVCSGETNVVFITNPLNEDLQHPIHVKNIQLVDTAEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNLGSVIPQAEYEWGGNSRLGIG
DYRIPKAMLTFLNGSRIPVMEKAPHKGILRDTTCKYIPAWQSYQCSGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKMYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKFCELD--R
HLNTEQFLPNLGSAGPGENYFDRVYQMLYLVVKGTTPVEVHTAAVIFVSFQLPAMTEDDF
FSSHNLVRNLALFLKISSDKIRVSRIMG-GSLR--RRRSV-GRAVELEIGAAPAWFLSNS
TAGQ--MRLS-ELQDI--SSSLGQAVILGKISTVLGFNISSVSITSPVPQPSDSGWIKVT
AQPVERSA--FPVHHLAFVSSLSVVAQPVVAQPGQPFSQQPSIKAVDAEGNCVSVGITSL
TLKAVLKDSNNNQVGGLSGNTTIPFSSCWANYTDL---TPHRTGKNYKIEFILANAVRV-
----ESRTFSLSAQTIPGGGGSSA-SSG--------------SSGSGHSRASTVGTPVQI
LTVVTGCLVGRLLLLEVFMAAAFILNTTAGSLVNQ-------------------------
-------------

------------------------------------------------------------
-----------GSKIIP-------------------KISGSFAQANQFNYGVDNAELGNS
VQLVSTFRSISCDVEKDASHSTQITCYTRARPEDSYTVRVSVDGVPITENNTCKGHINSW
ACSFNA-------KSFRTPTIRSITPLSGTPXXXXXXXXXXXXXXXXXXXXXXXXX-XXX
XXXXDYLVRMTCELVTPQTDTLYGLKLDHPNGDVGSMICKMTGTYIGKCHHNVSFILD-S
DFGRSFPQKMT-YFVSSLNKI-SMFQSY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 446)

AEVTRISPS
QGSVQGGTRLT-IRGRFFDKTDLPTRVLVGGQD----CDILNVTENTICCKTPP-RPH-S
LRTVYPGGRGLKLDVWNNSRPVHLEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXVRIAYHSANANSYFSSPTQGSD
DIPLQKGKKYYIEILVQEYRVSAFVDVGL-QYKNIYTEQQTGDAINEEQVIKSQTTIIQE
VQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XLLPADASD
FILQSALNDLWSIKPDTVQVTRT-QKSQNYTYAITFISARXXXXXXXXXXXXXXXXXXDI
TEQTKGKPSLETFTLSWDGIASPPLTPSSSEAEFQAAVEEMVSSKCPPQIANFEEGFIVK
YFRDYETDFNLEHFNRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNKIPYGDISLFPYN
QLCLAYKGFLANHIGLKFQYQDNSK-TTRSTVVQFPFDFTYGD-NWTYTCIDLLDLIQMK
YAGTNFSLQRISLWKASESQSFYVDTVYIGQTSTISVLNEMPKRRPPALASKGIFLKHFQ
VNQTKINGSVLTNQYSVTMAAYNCSYNIPMMTVSFGQIITNETEDESVYRGNNWPGKSQI
RIQRMQAASPPLRGSFDIQAYGHILK-XXPAAVSAADLQFALQSLEEVGQVSVTREGTCA
GYSWNIKWRSPCGKQNLLQINDSNIIGQNANM--TVTKMKEGGLFRQRILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCAFVWDPMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1260)

PLVLATSPSQGSYKESTILTISGSGFSPSS---
AISVSVGPVGCSVLSVI--ENEIKCQILNGSAGHFPVAVSIADVGLAQNVGG-EVFYFTY
QSQISHIRPVSGSLA-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRIG
GTVDISVITNGFQAMENDAFSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1444)

PVITDFNPKVRT-----IQGDINLTLKGYNFGS
ELTQIM-VYVGGKTCQVLHWNFTDI-RCHLPTL-------FPGRHDIYVEVRNWGFAST-
RDK

ENSGT00780000121902_0_Linker_7_8 (1444, 1452)

LNASIQYV

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVTNMFPQRGSLYGGTE-ITVMGFGFSRIPAENTVLIGSFPCNVTSSS
ESVIRCILHSTGNIFRVTNNGKDSVYGFGYAWSPSVLNVSVGDTVTWHWQALPYLRGIGY
RVFSVSSPGSVLYDGKGFTSGRQKSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGIHYYSSGYVDDAHSLFLQGVIH
VSPAETKHFPLHLFVGGTEATYAQ----GEPENLHLESSAAGCLATEPLCGLNNTGVKNS
NRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1779)

PSISNISPSTGTVNELITITGHGFSNLTCANKV-TVGSYPCVVEESSE
NRILCHIDPQNSMDVGIREIVTVTVYNLGFAVNTLAQE

ENSGT00780000121902_0_Linker_9_10 (1779, 1787)

FDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPNAGSTT
GMTRVTIKGSGFAASSASVEVLMGHFSCKVLFVNYTAIECETSPAPQQLVDMDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDRLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

PFITRISPNFIK-GSVEVSIDGEGFGTILEDIAVFSGNQRFRAV
DINDNNITVLVTPLPAGLHSLSVVVGAKGLALGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

ISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVAWVSPASGSIGGGTTLVI
TGNGFNPGSTVVLVGDDPCEIISVNSSAVYCRSPAGTAGMVDVKIFVDAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRRIVPSR-GPPGTEIQITGSNFGIDTLEISVMISNVQCYVTMVNDSVLQCVVG
DHAGGTFPITMQHMTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTVQNIHPSQG-SFGGGQNMTVTGTGFNPQSS
IILVCGSECEIDRLRSDYKTLLCKIPPNNG-RGPEQVCEVSV---VNGKDLSQSTAPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITEITPRRGSTAGGTRLTVMGSGFSENTQDIHITIAEAKCDVDYSNKTHIICM
TNAHASSGWAPVYVNIRNIGMAKLDNADFLYVDAWSSSFSWGGKAPPEEGSLVVITNGQT
ILLDQSTPILKMLLIQGGTLIFDDADIELQAENILITDGGSFQVGTEASPFQHKAVITLH
GHLRSPELPIYGAKTLAVREGTLELHGLPIPVIWTRLAHAAEAGERTLILQEAVTWKAGD
DIVIASTGHRNSQRENEKRTIASVSADGINITLTKPLNFTHLGITVTLPDGTMFEARAEV
GILTRNILIRGSGNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVNGRIAYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLSDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSFDRNICQKKVPLGEFFNNTVYSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNFEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTMKGLVLPFSEGLTVSSLNFMN
FDRPNCVALGVTSITGVCNDRCGGWSAKFVDIKYFHTTNKAGFRWEHEVVLIDVDGSLTG
REGHTVIPHSSLLDPSHCTQEAEWSLGFPGSVCDSSVSFHRLAFNKPSPVSLLEKDVVLS
DSFGISXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEDGYVI
ICHNFTQNPDMFNIMDKRNGSSNPLKRNXXXXXXXXXXXXXXXXXXXXXXXXXXX-----
---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLWSNDSFWQSSQENN
YTVPHPGANVVIPEXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXGGRLIAGWEDNPFKGELQIVLRGNHSTPDWALPEGPNQGSKVIGVFGELDLHGIP
HSIYKTKLSETAEAGSEVLSLMDAVDWQEGEEIVITTTSYDFHQTETRRITKILHGRKIL
ILNDTLSYTHLAESYHVPDTGQSYTLAADVGILSRNIKIVGEDYPGWFKESFGARVLVSS
FTENMMTFKXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIQGHDSSYIRGCAFH
NGFSPAIGVFGTDRLDIDDNIIHFTVGEGIR-IWGD-NNRVRGNLVALSIWPGTYQNRKD
LSLTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSLSNPSGRWTDNEAHGGLY
GVYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFSMIYTPAAISHKISSKTVQVKXXXXXXXXXXXXXXXXXX---------
-------------------------------------XXXXXXXXXXXXXXXXXXXXIMS
YNAITGRLDVTGKCSTFVWFKNVCSGETNVIFITNPFNEDLQHPIHVKNIQLVDIIEQSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGSSGSVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFPNGSRIPTTEKAPYKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDS
DKETRRLSPVAVVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLQLMLLNVDYKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFVAFQLPV-VEDDF
YSSHNLVRNLALFLKIPSDKIRISKIIRGNNSR--RKRSM-GHTIELEIGEPPTQSVSND
NAG--QMQLS-ELHEI--AGSLGQAVILGKISSVLGFNISTMSITSPIPNPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLSVIAQPVAAQPGQPFSQQPSVKALDSDXXXXXXXXXXX
XXXAVLKDSNNNQIGGLSGNTTIPFSSCWANYTDL---TPLRTGKNYKIEFILDNVVRV-
----ESRTFSLPVQSASSSSSGGSSS------------SS----SSSNSKASTVGTAAQM
MTIVIIFLIGRILLLEIFTAAVLILNVTKGSN----------------------------
-------------

----------------------------EGT-IW--LXGI---WGLWGL-------LLCA
ADPRT-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 177)

PKVTEIIPKYGSTNGATRLTIKGEGFAQANQFNYGVGNAELGNS
VQLVSSFRSIACDVEKDSSHSTQITCYTRAMPEDSYNVKVSVDGVPITESNTCRGR

ENSGT00780000121902_0_Linker_1_2 (177, 199)

INSW
ECTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PMIKSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 450)

AEVTMISPS
RGSIQGGTMLM-ISGRFFDQTDFPVRVLIGGQA----CDILNVTENSICCKTPP-KPE-V
LRTVYPGGRGLKLEVWNNSRPVHLEEILEYNEKTPGYLGASWVDSTSYIWPMEQDTFVAR
FSGFLVAPDSDVYRLYIKGDDRYAMYFSQTGHPKD--KVRIAYHSSNANDYFSSPTQRSD
DIYLQKGKEYYIEILLQEYRLSAFVDVGLYQHRNVYTEQQTEDAVNEEQVIRSQSTIVQE
VQVITFENWETSSATNEVQKITVTSPCVEANSCSRYQYRLTYNMEKT---EVLLPGDASD
FILQSALNDLWSIKPDTVQVIRT-QNPQSYVYVVTFISTRGDFDLLGYEVFEGDNVTLTI
TEQIKGKPSLDTFTLNWDGITSKPLTPWSSEAEFQAAVEEMVTAKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGKKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANSIALKFQYQDR-SKVTRSNDIQFTYNFTNGN-KWTYTCIDLLDLIQTK
YTGTNFSLQRIGFQKAAESQSFYVDAVYIGQTSTVSVWDEKPKRRLPALANKGIFLKHFQ
VNHTKINGSSMANQYSITMTSYNCSYNIPMMAVSFGQIITNETENESVYRGSNWPGESKI
RIQRIQAASPPLSGSFDIQAYGHILK-GLPATASAPDLQFALQSVEEVGRVSVTREGTCS
GYSWNIKWRSRCGKQNLLQVNDPNILGEKANM--TVVKIKEGGLFRQRILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDPMAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1260)

PLVRAINPSQGSYEKSAILTISGSGFSPDS---
ALSVSVGPMGCSLLSVDE-ENEIKCQILNGSAGHFPVAVSVAGVGLARNVGA-EVFYFT

ENSGT00780000121902_0_Linker_5_6 (1260, 1262)

Y
Q

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

NRISHIWPASGSLAEGGTLLTVTGFGFNENSKVLVANETCNVIEGDLNKITCRTPKRIE
GTVDISVITSGFQATAKDAYS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1446)

PVVTDFSPKVRTI-----QGEVNLTIKGYNFGN
ELTQNVEVYVGGKPCQIFQWNFTGI-RCLLPKL-------SPGKHDIHVEVRNWGFASTS
RDKLN

ENSGT00780000121902_0_Linker_7_8 (1446, 1452)

ASIQYV

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVTAMYPQRGSLYGGTE-ITIMGLGFSTIPTENTVLLGSFPCDVISSS
ENVIKCILRSTGNTFSITNTGEDSVHGLGYAWSPSVLNVSVGDTVTWRWQAHPFLRGMGY
RVFSVSSPGSVIYDGKGFTNGREKSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGIHYYSSGYVDEAHSTFLQGVIK
VLPAETRHIPLHLFVGSTEATYARVLLPKGPVNLHLGSSVAGCLATEPLCGPNNTRVTNS
DGLVFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1781)

PSINNISPSAGILNELITITGHGFSNLTCANKV-TIGNYPCIVEESSY
NSIICHIDPQNSMDVGIREIVTLTVYNLGTAINTPSNEFD

ENSGT00780000121902_0_Linker_9_10 (1781, 1787)

RRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDTVLPHAGSTT
GMTRVTIKGSGFAVSSAGVEVFMGHFPCKVLSVNYSAIECETSPAPQQPVKVDLLVHGVP
AQCQGDCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

AFVTRIFPNSVE-GPVKVLIEGDGFGTILEDIAVFIGNQQFRAI
DVNENNITVLVSPLPAGLHSLSVVVGSKGLALGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASITPTSGSIAGGTTLVI
TGNGFYPGNTTVTVGDEPCEIFSVNSSEVCCCTPAGTAGRVSVKIFVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRELVPNTEGPPGTKIQITGSNFGIDILDISVMIDNIPCNVTMVNDSVLQCTTG
DHAGGTFPVTMLHKTKGFAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LAIQNIHPSQG-SFGGGQTMTVTGIGFNPQTS
IILVCGSECAVDRLKSDCTTLLCQIPRNDG-RGPEQACEVSV---VNGKDLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMLLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITEIYPKRGSTAGGTRLTITGSGFSENMQDVLITIAKAKCDVEYSNKTYIICM
TNAHISSGWAPVHVSIRSMGMARLDDSDFLYVDAWSSNFSWGGKSPPEEGSLVVITKGQT
ILLDQNTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHRAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVSVIWTRLAHTAKAGERTLILQEVVTWKPGD
KIVIASTGHRHSQRENEKRTIASVSADGTKIILTTPLDHTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWSNKIPACPDGFDTGEFATQTCFQGKFGEEIGSDQFGGCIMFHA
PIPGANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVEWNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCEKGAEWVNGGALQFHNFVMVNNFEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTSKGLVLPFSEGLTVSSVHFMN
FDRPSCVALGVTSITGVCNERCGGWSAKFVDIQYFHTPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCTQEAEWSIGFPGAVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRNELQQSQPI
SGTLDPDVKDVIINFQAYCCLLQDCFPVHPPSRKPIPRKRPATYNLWSNDSFWQSSRENN
YTIPHPGANVVIPEGTWVVADIDIPPMESLVIWGVLELEDK-HSVGAAESSYRKVVLNAT
YISLQGGRLIGGWEDNPFKGELQIILRGNHSTPEWTLPEGPNQGSKVLGVFGELDLHGIP
RSVYKTKLSETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFYQTETRSIIKILHDQKIL
ILNDTLSYTHLAERYHAPGTGQSYTLAADVGILSRNIKILGEDYPGWFKESFGARVLVSS
FTQNMRKFKGNAR-ISNVEFYHSGQEAFRDSTDPRYAVTFLNLGQIQEHGSSFIRGCAFH
NGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVVLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSNQSNPMEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWKCWDYGIYFQ----------------TTESVRIY
NVTLVDNGMAISSMIYMPAAVSHKISSKTVKIKSSLIVGSSPGFNCSDVLTNDDPNIELS
AAHRSARPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGLMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKDIQLVDTTEQSK
IFIHRPDISKVNPADCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNSQFGIG
DYRIPEVMLTFPNGSRIPVTEKAPRKGIIRDSTCKYIPQWQSYRCFGMEYAMMAIESLDS
DTETRRLSPVAVVSDGYVDLINALGPQDHGWCAGYTCQRRLSLFHSIVALDKSYEIYFTG
TSPQNLRLVLLNVDHKKAVVVGIFFPTFQRLDVYVNNALVCPKNTVWNPQQKYCELN--R
HLYTEQFLPNLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSRIIQGDSLR--RKRST-GLTVALEIGDAPLQFLSDG
TAGQ--MQLT-ELQKI--ADSLGQAIISGKTSSILGFNISFMSITDPIPSPSDSAWIKVT
AQPVERFA--FPVHHVAFVSSLSVITQPVAAQPGQPFSQQPSVKAVDSDGNCVSVGITSL
TLKARLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGE---------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MGH-LW--LLET---WGLCWL-------LLCA
ADLRT-----ESSKTI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVMPKYGSINGATRLTIKGEGFSQANQFNYGVDNTELGNS
VQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPIAENHTCRGRSGSW
ACSFNT-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNITPLSGTPGTLITIQGRIFTDVYGSNTAVSSNG-RNV
RILRVYIGGMPCELLIPQSDDLYGLKLDHPSGDMGSMICKITGTYIG--HHNVSFILD-S
DYGRSFPENMT-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 426)

EITSISPS
KGSIQGGTVLT-INGQFFDQTDLPVKVLVGGQS----CDVLNVTENRIYCKTPP-LPP-V
LKSLY

ENSGT00780000121902_0_Linker_3_4 (426, 473)

PGGRGLKLEVWNNSRPVHLEEIFEYNEGTLGYMGATWVDSASYVWPL

PF07691 // ENSGT00780000121902_0_Domain_4 (473, 565)

EQDTFVAR
FSGFLVPPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANSNSYFSSPSQRSD
DIHLHKGKEYYIEILLQEHKLSAF

ENSGT00780000121902_0_Linker_4_5 (565, 1170)

VDVGLYQYKTVYSEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNATHEVQKITVTSSCVEASSCSLYQYRLMYGKEKT----VLLAADASD
FILQSALNDLWSIKPDTVQVKRT-QNLQSYSYIITFLSTRGDFDLLGYELFAGNNVTLDI
TEQTKGKPSLETFTLNWDGVASMPLNPRSSEVEFQVAVEEMVSTKCPPQIAHLEEGFVVK
YFRDYETDFDLEYISRGQKTAETDAYCGRYSLKNPAVLFDSADAKPNKLPYGDILLFPYN
QLCLAYKGFLANYIGLKFHYQDN-GKITRSTDMQFTYNFAYGN-NWTYTCIDLLDLIQAK
HSGTSFSLQRISLQKASESQSFYVDVVYIGQTPTLSTFNEMPKRRLAALANKGIFLEHFQ
VNQTRINGSTMIVQYFVTMTSYNCSYNIPMMAVNFGQKITNEIETESVYRGINWPGESKI
RIQRIQEASPPISGSFDIQAYGHTLK-GIPAAVSAADLQFALQSLKEMGKVSVTREGTCA
GYTWNIKWRSTCGKQNLLQMNDSNITGVKANI--TVAKIKEGGLLRQHILGDLLRVPSQQ
PQVEVYVNGIPAKCSGNCGFTWDPMTTPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLATRPSQGSFEESTILTIVGSGFSPSS---
AVSVSVGPTCCSILSVN-E-NEITCQIRNGSAGRVPVTVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DAGLAQHAEG-EGFYFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1338)

QISHIWPDSGSLA-GGTLLTISGFGFSESSEVLVGNETCKVIEGDTNRITCRTPKRTE
GTVDISVTTNGIQATAK

ENSGT00780000121902_0_Linker_6_7 (1338, 1348)

DVFSYSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PVITDFNPKVRTI-----LGDVNLTIKGYNFGN
ELAQNMVVHVGGKTCQVLSWNVTGI-QCRLPLL-------PPGKHDIYVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1454)

TWGFAST-
RDKSNASIQYILE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHMFPQRGSLYGGTE-ITVKGFGFSTIPTENTVLLGTFPCNVTSSS
ESIIRCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNVFRITNNGDNLEHGFGYAWSPSVLNVSVGDTVIWYWQAHPFLKGIGY
RVFSVSSPGSIIYDGKGFTNGRQKSQSGSFSYRFTSPGTHYYSSGYIEESHSISLQGVIN
VLPAETRHVPLQLFVGGMEATYAQ-----GPENLHLGSSVAGCLATDPLCGLNNTMAEHS
NRLLFELSSCMS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1759)

PCISNITPSSGTANELITIIGHGFSNLTCANKV-TIGSYPCIVKESNN
TSIICHIDPQNSMDVGIR

ENSGT00780000121902_0_Linker_9_10 (1759, 1787)

ELVTLIVYNLGTAINTLFNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDTVLPNEGSTT
GMTRVTIYGSGFTGSSEGVEVFMGRFPCKVLTVNYTAIECESPPASEQRVHVDVLIHGEP
ARCQGTCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPDSIV-GSAKVLVEGKGFGTVLEEISVFIGNQQFRVV
DVTEKNLTVLLTALPAGLHSLRVVVRSKGLALGNG

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVQPASGSMGGGTALLI
TGNGFYPGNTTVTVGEDPCQILLVNSSQIYCKTPAGEAGVANLKIWVNTVIYPPLPFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
SEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRGIIPNR-GPPGTEIEITGSNLGTDISEISVMINDVQCNVTMVNDTVLQCLVG
AHEGGVFPVMMHHKTRGSAISTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

QIQNIHPRQG-SFGGGQTMTVRGTGFNPQNS
ILLVCGSECVIDRLRSNSTALFCEIPPNNG-PGPEQACEVRV---VNGQDSSPSSTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SMSVT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2301)

PLITEVFPSRGSTAGGTSLTVMGSGFSENI---QITIAGARCDIQYSNKTHIICL
TTAHTPSGWAPVLLRDRNMG

ENSGT00780000121902_0_Linker_15_16 (2301, 2321)

MAKLENVDFLYVDVWSSNNS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGVSPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAIITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTAKAGEQTLILQQAVTWKAGD
SIVIASTGHRHSQRENEKRIIASVSANGVNITLSEPLNHTHLGITITLPDGTPFEARAEV
GILTRNIIIRGSNNVEWNNKIPACPEGFDTGEFATQTCLQGKFGEELGSDQFGGCIMFHA
PLPNSDMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFNSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFHSLTTWNCQKGAEWVNGGALQFHNFVMVNNHEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGYLEELGLGSAFCTSRGLVLPFSEGLTVSSVHFMN
FDRPTCVALGVTSITGVCNDRCGGWSTKFVNIQYFHTPNKAGFRWEHEALLIDIDGSLTG
HKGYTVIPYSSLLDPSHCTQEAQWSVGFPGSVCDTSVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSVVPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLNWNTSKNGDWHLETNTSTLYYLVSGRSDLQQSQLT
SGTLDPNVKDVIINFQAYCCILQDCFPVHPSSRKPVPRKRPTTYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSPENN
YTIPHPGASVIIPEGTWIVADTDLPSMERLIVWGVLELEDK-SKVGTAGPSYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHTTPEWALPEGPNQGAKVLGVFGELDLHGLP
RSIYKTKLSETAEAGSKVLSLVDAVDWQEGEEIVITTTSYDLHQTETRSIVKILHGHKIL
ILNDSLSFTHLAERYHVPETGQSYTLAADVGILSRNIKVIGEDYPGWSKDSFGARILVGS
FMGNMMTFQGNAR-ISNVEFYHSGQEGFRDSTDPRYAITFLNLGQVQEHGLSYVRGCSFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLVTLSVWPGTYQDRKD
LSSSLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSQSNPMEDWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWACWDYGIYFQ----------------TTESVHIY
NVTLVNNGMAIFSMIYMPAAVSHKISSKIIKIKNSLIVGSSPEFNCSDVLTNDDPNIELT
ATHRSSRHP--------------------S--GGRSGICWPTFASAHNLAPRKPHAGIMS
YNAISGLLDVSG--STFVGFKNVCSGERNVIFITNPLNEDLQHPVHVKKIQLVDSTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNKQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNQSYEVYFTG
TSPQNLRLMLLNVDQNKAVLVGIFFSTLQRLDVYVNNSLVCPKHTVWDTQKKHCKLN--R
HLRTGQFLPNLDST-VGENYFDKTYQMLYLLVKGTIPIEIHTATVIFVSFQLPGVTEDDF
YISQNLVRNLALFLKIPSDKIRVTRIIGGESLR--RKRSM-RHTIEVEIGEAPTQLLPND
TTGH--MQLS-ELQET--AASLGQAVILGKISSILGFNVSSMSITTPIPRPSDSGWTKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAHPGQPFSQQPSVKATDSNGNCISVGITSL
TLKAILKDANNNQVSGLNGNTTIPFSSCWANYTDL---TPLRIGKNYKIEFLLDNNIRV-
----ESRAFSLTAQSISGGGGGSSSSSG---------S----SSSSSHNEASTVRPSVHI
LTIVMSCLMGRVLLLEIFMATVFILNMIAGKDGSF---CA--------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LMCA
ANPRT-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFTYGVDNAELGNS
VQLVSSFQSIACDVEKDASHSTHITCYTRAMPEGSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIVQSSNG-KNV
RILRVYIGGMPCELLIPQSDSLYGLKLDHPNGDMGSMICKTTGTFIG--HHNVSFILD-S
DYGRSLPQKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLSKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 428)

EVTTIFPS
RGSIQGGTTLT-ISGQFFDQTDFPVRVLVGGET----CDTLNVTENSISCKTPP-KPH-I
LKTVYPG

ENSGT00780000121902_0_Linker_3_4 (428, 453)

GRGLKLEVWNNTCPVHLEEILEYNE

PF07691 // ENSGT00780000121902_0_Domain_4 (453, 558)

KTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQSGLPE--DKVRIAYHSANANSYFYSPAQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVIRT-QNTWSYIYTITFISTRGDFDLFGYEVFEGNNVTLDI
TEQTKGKPSLETFTLNWDGISSKPLTPWSSEAEFQRAVEEMVSTKCPPQITNFEEGFVVK
YFRDYETDFNLERINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDSSSKIIRSTDVQFTYNFAYGN-NWTYTCIDLLDLIRTK
YTGTNICLQRISLQKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNWTKINGPTMTHQYFVTMTSYNCSYNIPMMAVSFGQIITHETENKIVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGRILK-GLPADVSAADLQFALQSLEGMGRVSVTREGTCA
GYTWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSAITPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLGTSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCYLLSVD-E-KEIKCQILNGSAGHAPVAVSIV

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTINGYNFGN
ELTQNMVVYVGGKTCQLLHWNFTDI-RCLLPKL-------PPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIKGFGFSTISAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGFVDEAHSIFLQGVIN
VLQAETRHIPLHLFVGSSEATYAR----GGLENLHLGSSVTGCLATEPLCGLNNTKVKNS
ERLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSSGTVNELITIIGHGFSNLPCANKV-TIGSYPCIIEESSD
NSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNVGSTT
GMTRVTIKGSGFAVSSTGVEVLMGHFPCKVLSVNYRAIECETSPAVQQLVDVYLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PYITGISPNSII-ESVKVIIEGEGFGTVLDDIAVFIGNQQFRVI
DVNENNITALVTSLPVGRHSLSVVVGSKGLALG

ENSGT00780000121902_0_Linker_11_12 (1954, 1962)

NLSVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASVSPTSGSTGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISIDPNEVYCHTPPGTAGMVGVKIFVNTISYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPSR-GPPGTEIEITGSNFGIEILDISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAISTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAVDRLRSDYTTLLCEIPSNNG-RGAEQACEVSV---VNGKDLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SVFLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVMGSGFSENIEDVHITIAEAKCAVQCSNKTHIICM
TNAHPLSGWAPVHVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNIS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGITVTLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLHFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNIFQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPLPARFNSFTAWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLDELGTGSAFCTRKGLVLPFSEGLTVSSVHFIN
FEHPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKDEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLQQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPMPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGIWIVADIDMPSMERLIIWGVLELEDR-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTQDWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETADAGSKILSLMDAVDWQEGEEIVITTTSYDFHQTETRSIIKILHDRKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSQDSFGAHVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIQGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINGGTNTVLQNNVVAGFARAGYRIDGEPCPSQFNPMEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTENVYIY
NVTLVDNGMAIFPMIYLPAAISHKISNKKVQIKSSLIVGSSPGFNCSDILTNDDPNVELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGFVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFLNGSKIPVTEKAPHKGIIRDSTCKYIPQWQSYQCFGMEYALMVIESLDP
DTETRRISPVAVMGNGYVDLLN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--T
LLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQLPAVTEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIREKSLR--RKRSM-GFIIEIEIGDPPIQFLNNG
TTGQ--MQIS-ELQET--AGSLGQAVILGKISRILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVALVSSLSVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDCNNNQVSGLSGNTTIPFSSCWANYTDL--T-PFRTGKNYKIEFILDNVARV-
----ESRTFSLQAESVSSSSS------------------SSSGSSSSNSKASTVGTSAQI
MTVVISSLIGRMWLLEIFMAAVSTVNITLSK-----------------------------
-------------

------MKDLKH-------SSPYWGIGHLSF-TT--VDHD---WSTTAI-------FVCL
A---------DGSETV

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 170)

PKVTEVIPKYGSMNGATRLTVKGEGFSQANQFNYGTDNTELGNR
VQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDTYTVRVSVDGVPIAE

ENSGT00780000121902_0_Linker_1_2 (170, 199)

NNTCKGLTSSW
ACSFST-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-RNV
RILRVYVGGMPCELLIPHSDDLYGLTLDQPSGDTGSMTCKMTGTYIG--HHNASFILD-S
DYGRSFPEKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNKI-SILDLCGMFT------------------TFS

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 435)

ITMMSPS
KGSTQGGTTLT-IHGRFFDQTDLPVRALVGGQA----CDILNITENSIYCKTPP-RPT-I
LKTVYPGGRGLKLEVWNNSRPVHLEEIFEYNEHTPGYMGASWIDSASYAWPMEKDTFVARFSGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRPE--DKVRIAYHSANANSYFSSSTQRSDEIYLQRGKAYYIEILFQEYTLSAFVDVGLYQYKNVFTEQQTGDAANEEQAIKSQSTVIPEVQIITLENWETTNATNEVQQVEVSSPCVGTNSCSLSQYRFIYNMEKT----VWLPADASDFALQSALNDLWSIKPDSVHVTSK-RDLQRCIYTITFVSVRGDFDLLGYEVFEGSNVTLDITEQTKGKPSLETFTLNWDGVPSKPLASESSEAEFQVAVEEMVSAKCAPEISHLEEGFLVKYFRDYETDFDLDHINRGQKTSETDAYCGHCSLKNPAVLFDSTDVKPNKLPYGDILLFPYNQFCLAYKGSLANYIGLKFKYQDS-GKIIRSADKQFEYNFSSGN-KWTYTCIDLLDFLQTKYAGTSFSLQRIRLQKSSEFQSFYVDAVYIGQTPTVSALGEVPKRRPPALANKGIFLKYFHVNKTKVNGSTMAIQYSVFMTLYNCSHNIPMMAVSFGQIITNETKDESVYRGNNWPGESKIRIQKIREASPPISGSFDIQAYGHTLK-GIPAAVSASDLQFALQSLEEIGRVSVRREGTCAGYTWTIAWKSPCGRQPLLQINDSNITGEKANV--TVTTTKEGGLFRQRIPGDMLRTPNQQPQVEVYVNGIPAKCSGDCRFTWDPMTTPLVLTTTPSEGSYAESTILTIAGSGFSPTS---AVSVSVGSTSCSLLSVN-E-NEIKCQILNGSAGRVPVVVSNADGGLARNLEG-EGSHFIYRTQINHVWPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCSVIKGDLNMITCRTPKRTEGTVDISVITNGIQATAKDGFSYSCLHTPVITEFSPKERAV-----LGKKFFTIKGYNFGNELAQNM-VYVGGKACQVLHSNFTDI-SCLLPKL-------PPGKHDIYVNVRNWGLAST-RNKLNASIWYVLEVTHMFPQRGSLYGGTE-LTIEGSGFSRTPTENSVFLGSFPCDITSSSENVIKCTLRSTGTVFRITNNGSHLEHGIGYAWSPSILNVTVGDTVVWHWQAYPFLRSIGYRVFSVSSPGSVTYDGKGFTNGRQKSASGSFSHRFTSPGIHYYSSGYIDETHSVSLQGVINVLPAETRRIPLHLFVGNVEATYAL----ADPQNLHLTSTAASCLATDPLCGLNDTRVKNPNQLLFELSSCVSPSISNITPSSGTVNELITISGHGFSSLACANKV-TIGSYPCVVEESSQNSITCHIDPQNSMDVGIREIVTLIIYNLGTAINTAPSEFDRQFVLLPNIDMVMPNEGSTTGMTRVTIQGSGFMASSTSVEVFMGDFPCRVLTVTYTAIECETSPAPQQLVLVDLLIHGVPARCQGNCSFSYLENIAPCVTRVSPNSIK-GSVHVLIEGEGFGTVLEEVSIFIGSQQFSAVEVNENNITALVTPLAAGLHSLRVVVGSKGLALGNVTISSPTVASVSPTSGSVAGGTTLTITGNGFSPGNTTVTVGSNPCQIVFINSSEVYCSTPAGRAGTANLKISVKEVVYPPLSFTYTVEDTPFLKGITPNR-GPPGTEVEIAGSNLGFDIGDVSVMIEDSACNVTTVNDSMLQCIVGEHAGGIFPVTMLHTTKGSALSSVVFEYPLYIQDIHPKQG-SFGGGQTMTVTGTGFDPQNSSLLVCGSECAVDKLGSDSKTLFCEIPPNNG-SGPDQACGVSV---VNGKDSSQSTVPFTYTLSLTPLVTEISPRRGSTVGGTRLTVTGSGFSENTQDVHVSIANDKCDVQYSNKTHIICVTSPHAPSGWAPVQTSIRNFGKAKVENPDFLYVDLWSANSSWGGKPPPEEGSLAVITEGQIILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHQAVITLHGHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTANAGERTLIVQEAVTWKAGDSLVIASTGHRHSQGENEKRTIASVSADGTHITLTRPLNYTHLGISVTLPDGTEFEARAEVGILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHAPLPGANMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSYDRDICQKRIPLGEFANNTVHSQGWFGLWIFEEYFPMQTGSCTSTEPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVVVNNQEAGIETKRILASYVGGWGEANGAVIKNARIVGHLDELGMGSAFCTSKGLVLPFSQGLTVSSVRFMHFDRPDCVALGVTSITGVCNDRCGGWSSKFVDIQYFHAPNKAGFRWEHEAALVDVDGSLTGHRGHTVIPHSSLLDPTHCTQEAAWSLGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLSDSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFRGAEHLTNISYTSTFYGFKEEDYVIISHNFTQNPDVFNVVDMRNGSSNPLNWNTSKNGDWHLEVNTSTLYYLVSGRSELPQSQPIPGTLDPDAKDVIINFQAYCCVLQDCFPVHPPSRRPIPRTRPASYNLWSNESFWQSSPENNYTVPHPGANVVIPEGSWIVADTDIPPMEKLIIWGVLELEDR-SEVESATPSYRRVVLNATYISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGLPHSVYKTKLSETAEAGSRILSLVDAVDWQEGEDIVITTTSYDLHQTETRRIAKILHGHKILVLNDSLSYTHLAERQQIPETGQTYTLAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGSLTGKMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGLSYVRGCAFHHGFSPAIGVFGTDGLVIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKDLSSTLWHAAIEVNRGTNTVLQNNIVAGFGRAGYRIDGEPCSSQANPMENWFTNEAHGGLYGIYMNQDGLPGCSLI-----QGFTVWTCWDYGIYFQ----------------TPDSVHIYNVTLVNNGMGIFPMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELTSAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLDVSG--STFIGFKEACSGETNVIFITNPLNEDLQHPIHVKNVQLLDTTEQSKVFIHRPDTSKVNPSDCVDMVCDAKRKSLLRDMDGSFLGSSGSVIPQAEYEWDGNSRLGIGDYRIPKAMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPAWQSYRCSGMDYAMLVIESLDSDTETRRLSPVAIVSNGYVDLIS--GPQDHGWCAGYTCQRRLSLFHSIMALNKMYEVYFTGTSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKFCELD--RHLNTEQLLPNLSSTIPGENYFDRNYQMLYILVKGTTPVEVHTATVIFVSFQLPAVTEDDFFSSHNLVRNLALFLKIPNDKIRVSRIIG-ASLR--RKRSA-GRVMELEIGDAPAWFFQNSTAGQ--MQLS-ELQEI--SGTLGQAVILGKISTILGFNISSMSVTSPIPQPTDSGWIKVTAQPVERSA--FPVHYMAFVSSLSVVAQPVATQPGQPFPQQPSVKAVDHEGNCVSVGITSLTLKAILKDSNNNQVGGLGGNTTIPFINCWANYTDL---TLHRTGKNYKIEFILADMVRV-----ESRTFSLAAQTVPGGGGSSP-SSG--------------SSGGGHGKASAVGTPLQTLIVVAGCLVGRLLLLEVFMAAVFILNPATVNR------------------------------------

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKLEVWNNSRPVHLEEIFEYNEHTPGYMGASWIDSASYAWPMEKDTFVAR
FSGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRPE--DKVRIAYHSANANSYFSSSTQRSD
EIYLQRGKAYYIEILFQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYTLSAFVDVGLYQYKNVFTEQQTGDAANEEQAIKSQSTVIPE
VQIITLENWETTNATNEVQQVEVSSPCVGTNSCSLSQYRFIYNMEKT----VWLPADASD
FALQSALNDLWSIKPDSVHVTSK-RDLQRCIYTITFVSVRGDFDLLGYEVFEGSNVTLDI
TEQTKGKPSLETFTLNWDGVPSKPLASESSEAEFQVAVEEMVSAKCAPEISHLEEGFLVK
YFRDYETDFDLDHINRGQKTSETDAYCGHCSLKNPAVLFDSTDVKPNKLPYGDILLFPYN
QFCLAYKGSLANYIGLKFKYQDS-GKIIRSADKQFEYNFSSGN-KWTYTCIDLLDFLQTK
YAGTSFSLQRIRLQKSSEFQSFYVDAVYIGQTPTVSALGEVPKRRPPALANKGIFLKYFH
VNKTKVNGSTMAIQYSVFMTLYNCSHNIPMMAVSFGQIITNETKDESVYRGNNWPGESKI
RIQKIREASPPISGSFDIQAYGHTLK-GIPAAVSASDLQFALQSLEEIGRVSVRREGTCA
GYTWTIAWKSPCGRQPLLQINDSNITGEKANV--TVTTTKEGGLFRQRIPGDMLRTPNQQ
PQVEVYVNGIPAKCSGDCRFTWDPMTTPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLTTTPSEGSYAESTILTIAGSGFSPTS---
AVSVSVGSTSCSLLSVN-E-NEIKCQILNGSAGRVPVVVSNA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DGGLARNLEG-EGSHFIY
RTQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1338)

INHVWPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCSVIKGDLNMITCRTPKRTE
GTVDISVITNGIQATAK

ENSGT00780000121902_0_Linker_6_7 (1338, 1348)

DGFSYSCLHT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITEFSPKERAV-----LGKKFFTIKGYNFGN
ELAQNM-VYVGGKACQVLHSNFTDI-SCLLPKL-------PPGKHDIYVNVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1454)

AST-
RNKLNASIWYVLE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHMFPQRGSLYGGTE-LTIEGSGFSRTPTENSVFLGSFPCDITSSS
ENVIKCTLR

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFRITNNGSHLEHGIGYAWSPSILNVTVGDTVVWHWQAYPFLRSIGY
RVFSVSSPGSVTYDGKGFTNGRQKSASGSFSHRFTSPGIHYYSSGYIDETHSVSLQGVIN
VLPAETRRIPLHLFVGNVEATYAL----ADPQNLHLTSTAASCLATDPLCGLNDTRVKNP
NQLLFELSSCVS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSSGTVNELITISGHGFSSLACANKV-TIGSYPCVVEESSQ
NSITCHIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLIIYNLGTAINTAPSEFDRQFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVMPNEGSTT
GMTRVTIQGSGFMASSTSVEVFMGDFPCRVLTVTYTAIECETSPAPQQLVLVDLLIHGVP
ARCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PCVTRVSPNSIK-GSVHVLIEGEGFGTVLEEVSIFIGSQQFSAV
EVNENNITALVTPLAAGLHSLRVVVGSKGLALGNV

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PTVASVSPTSGSVAGGTTLTI
TGNGFSPGNTTVTVGSNPCQIVFINSSEVYCSTPAGRAGTANLKISVKEVVYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
VEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKGITPNR-GPPGTEVEIAGSNLGFDIGDVSVMIEDSACNVTTVNDSMLQCIVG
EHAGGIFPVTMLHTTKGSALSSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

YIQDIHPKQG-SFGGGQTMTVTGTGFDPQNS
SLLVCGSECAVDKLGSDSKTLFCEIPPNNG-SGPDQACGVSV---VNGKDSSQSTVPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2300)

PLVTEISPRRGSTVGGTRLTVTGSGFSENTQDVHVSIANDKCDVQYSNKTHIICV
TSPHAPSGWAPVQTSIRNF

ENSGT00780000121902_0_Linker_15_16 (2300, 2321)

GKAKVENPDFLYVDLWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKPPPEEGSLAVITEGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHQAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTANAGERTLIVQEAVTWKAGD
SLVIASTGHRHSQGENEKRTIASVSADGTHITLTRPLNYTHLGISVTLPDGTEFEARAEV
GILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHA
PLPGANMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSYDRDICQKRIPLGEFANNTVHSQGWFGLW
IFEEYFPMQTGSCTSTEPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVVVNNQEAGIET
KRILASYVGGWGEANGAVIKNARIVGHLDELGMGSAFCTSKGLVLPFSQGLTVSSVRFMH
FDRPDCVALGVTSITGVCNDRCGGWSSKFVDIQYFHAPNKAGFRWEHEAALVDVDGSLTG
HRGHTVIPHSSLLDPTHCTQEAAWSLGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFRGAEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDVFNVVDMRNGSSNPLNWNTSKNGDWHLEVNTSTLYYLVSGRSELPQSQPI
PGTLDPDAKDVIINFQAYCCVLQDCFPVHPPSRRPIPRTRPASYNLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSPENN
YTVPHPGANVVIPEGSWIVADTDIPPMEKLIIWGVLELEDR-SEVESATPSYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGLP
HSVYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3473)

SETAEAGSRILSLVDAVDWQEGEDIVITTTSYDLHQTETRRIAKILHGHKIL
VLNDSLSYTHLAERQQIPETGQTYTLAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGS
LTGKMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGLS

PF13229 // ENSGT00780000121902_0_Domain_19 (3473, 3663)

YVRGCAFH
HGFSPAIGVFGTDGLVIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNIVAGFGRAGYRIDGEPCSSQANPMENWFTNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTVWTCWDYGIYFQ----------------TPDSVHIY
NVTLVNNGMGIFPMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDVSG--STFIGFKEACSGETNVIFITNPLNEDLQHPIHVKNVQLLDTTEQSK
VFIHRPDTSKVNPSDCVDMVCDAKRKSLLRDMDGSFLGSSGSVIPQAEYEWDGNSRLGIG
DYRIPKAMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPAWQSYRCSGMDYAMLVIESLDS
DTETRRLSPVAIVSNGYVDLIS--GPQDHGWCAGYTCQRRLSLFHSIMALNKMYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKFCELD--R
HLNTEQLLPNLSSTIPGENYFDRNYQMLYILVKGTTPVEVHTATVIFVSFQLPAVTEDDF
FSSHNLVRNLALFLKIPNDKIRVSRIIG-ASLR--RKRSA-GRVMELEIGDAPAWFFQNS
TAGQ--MQLS-ELQEI--SGTLGQAVILGKISTILGFNISSMSVTSPIPQPTDSGWIKVT
AQPVERSA--FPVHYMAFVSSLSVVAQPVATQPGQPFPQQPSVKAVDHEGNCVSVGITSL
TLKAILKDSNNNQVGGLGGNTTIPFINCWANYTDL---TLHRTGKNYKIEFILADMVRV-
----ESRTFSLAAQTVPGGGGSSP-SSG--------------SSGGGHGKASAVGTPLQT
LIVVAGCLVGRLLLLEVFMAAVFILNPATVNR----------------------------
-------------

----------------------------MGH-LW--LSGT---WFLFGL-------LWCA
ADSHK-----GSSETI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNTELGNH
VQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDTYSVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVAENNTCKGVASSW
ACSFST-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIKGRLFTDVYGSNTALSSNG-RNV
RILRIYIGGMPCELLIPHSDDLYGLKLDHANGDTGSVTCKTTGTYIG--HHNVSFILD-S
DYGRSFPEKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 438)

PEVVMVSPS
KGSTEGGTLLT-IHGHFFDQTDLPVRVLVGGQA----CAILNVTENTIYCKTPP-KPH-I
LKATYPGGRGLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTE--DKVRIAYYSGNANTYFSNSTQRSDEIHLQKGKEYYIEILLQEYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVVPEVQIITLENWETADVTNEVQQVTVTSPCVGANSCSLSQYRFIYNMEKT----VWLPADASDFTLKSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSITEQTKGKPNLETFTLNWDGIASKPLTPESSEAEFQVAVEEMVSAKCPPEIAHLEEGFLVKYFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYNQLCLAYKGSLANFIDLKFKYQDS-GKIIRSADVQFEYNFASGN-KWTYTCIDLLDFLQTKYAGTSFSLQRITLQKSSEFQSIYVDAVYIGQTPTVSVLDDMPKRRPPALANKGIFLKHFQVNRTKLNGSAMTIQYSVTITSYNCSHNIPMMAVSFGQIITNETKNELVYRGNNWPGESKIRIQKIQEASPPISGSFDVQAYGHTLK-GIPAAVPAADLQFALQSLEEIEQVSVNREGTCAGYSWSIRWTSPRGKQPLLQINDSNIIGEKANV--TVTTIKEGGLFRQRIPGDMLRTLNQQPQVEVYVNGIPAKCSGDCGFTWDAMITPLILTTTPSEGSYAESTILTIAGSGFSPTS---AVSVSVGSTRCSLLSVE-E-NEIKCQILNGSAGHVPVAVSIADVGLAQNLEG-EGSHFIYRSQISHVWPDSGSLA-GGTLLTISGFGFSENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQVTAKDSFSYSCLQTPVVTDFSPKERTV-----LGKVNLTIKGYNFGNELAQNT-VYVGRKHCQVLHSNFTDI-TCLLPTL-------PPGKHDIYVKVRNWGLAST-RNKLNASILYILEVIHMFPQRGSLYGGTE-ITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTLHSTGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGYRIFSVSSPGSVTYDDKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVINVFPAEARHIPLYLFVGNIEATYVP----AGPAHLQLASTAAGCLATEPLCGLNDTRVKHSNKLFFELSNCISPSIINITPSTGTANELITIIGHGFSSLPCANKV-TIGSYPCVVEESSENSIICHIDPQNSMNVGIREIVTLIVYNLGTAINTLTKAFDRRFVLLPNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVPAQCQSNCSFSYLENIAPYVTGIFPNSIQ-GYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNLTISSPAVASVSPTSGSIAGGTTLMITGNGFSPGNTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAIIYPPLSFTYAMEDTPFLKRIIPNR-GLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVTMLHKTKGSAVSSVAFEYPLSIQNIYPTQG-SFGGGQTLTVTGMGFDPWNSTILVCNSECAVDKLRSNSTTLFCVIPPNNG-KGHDQVCGVSV---VNGKDSSHSTKLFTYTLSLTPLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLENADFLYADVWSANSSWGGSPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGGTLIFDEANIELQAENILITDGGVLQIGTEASPFQHRAVITLHGHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTLTVQEAVTWKAGDNIVIASTGHRHSQAENEKRTIASVSADGMHITLTKPLNYTHLGITTTLPDGTVFEARAEVGILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHAPLPGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLWIFEEYFPMQTGSCTSTVPVPAIFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNNEAGIETKRILAPYVGGWGESNGAVIKNAKIVGHLDELGMGPTFCTSKGLVLPFSQGLTVSSVHFMNFDRHACVALGVTSITGVCNDRCGGWSAKFVGIRYFHAPNKGGFRWEHEAVLIDVDGSLTGHRGHTVVPHSSLLDPSHCTQEPAWSIGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLSDSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVIISHNFTQNPDMFNVVDMRNGSANPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPISGTLDPGVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNESFWQSSPENNYTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDK-SEIGVAGPTYRRVVLNATYISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLPHSVYKTKLLETAEAGSKILSLVDAVDWQEGEDVVITTTSYDLHQTEIRRIAKILHGHKILILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDDYSVLSKDSFGARILVGSFTGNMMTFKGNAR-ISNVEFHHSGQEGYRDSTDPRYAVTFLNLGQIQDHGLSYVRGCAFHHVFSPAIGVFGTDGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKDLSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANSMENWFNNEAHGGLYGIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIYNVTLVNNGMSIFSMVYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELTSAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLHVSD--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLIDTIEQSKVFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNSQLGIGDYRIPKAMLTYLNGSRIPVTEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDSDTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKKYEVYFTGTSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKHCELE--RHLSTEQFLPNLGSTVPGENYFDRTYQMLYLFLKGTTPVEVHTATVIFVSFHLPVMTADEFFSSHNLVRNLALFLKIPSDKIRVSRIIG-ASLR--KKRST-GHIMEFEIGAAPTQFLSNSTTGQ--MQLS-ELQEI--TDSLGQAVVLGKISTILGFNISSMSITSPIPQPTDSGWIKVTAQPVERSA--FPVHYLALVSSLSVVAQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSLTLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDL---TPHRTGKNYKIEFVLDNTVRV-----DSRPFSLSAQSVPGGSGSSP-GSG--------------SSSSGHSKASSVGTPVQTLAVITACLVGRLLLLEVFMAAVFILNTTVGIN---------------------------------

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVAR
ISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTE--DKVRIAYYSGNANTYFSNSTQRSD
EIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVVPE
VQIITLENWETADVTNEVQQVTVTSPCVGANSCSLSQYRFIYNMEKT----VWLPADASD
FTLKSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSI
TEQTKGKPNLETFTLNWDGIASKPLTPESSEAEFQVAVEEMVSAKCPPEIAHLEEGFLVK
YFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYN
QLCLAYKGSLANFIDLKFKYQDS-GKIIRSADVQFEYNFASGN-KWTYTCIDLLDFLQTK
YAGTSFSLQRITLQKSSEFQSIYVDAVYIGQTPTVSVLDDMPKRRPPALANKGIFLKHFQ
VNRTKLNGSAMTIQYSVTITSYNCSHNIPMMAVSFGQIITNETKNELVYRGNNWPGESKI
RIQKIQEASPPISGSFDVQAYGHTLK-GIPAAVPAADLQFALQSLEEIEQVSVNREGTCA
GYSWSIRWTSPRGKQPLLQINDSNIIGEKANV--TVTTIKEGGLFRQRIPGDMLRTLNQQ
PQVEVYVNGIPAKCSGDCGFTWDAMIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLILTTTPSEGSYAESTILTIAGSGFSPTS---
AVSVSVGSTRCSLLSVE-E-NEIKCQILNGSAGHVPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNLEG-EGSHFIY
RS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGTLLTISGFGFSENSTVLVGNETCNVIEGDLNRITCRTSKRIE
GTVDISVITNGIQVTAKDSFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVVTDFSPKERTV-----LGKVNLTIKGYNFGN
ELAQNT-VYVGRKHCQVLHSNFTDI-TCLLPTL-------PPGKHDIYVKVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1457)

AST-
RNKLNASILYILEVIH

PF01833 // ENSGT00780000121902_0_Domain_8 (1457, 1510)

MFPQRGSLYGGTE-ITIMGFGFSTIPTENSVLLGSFPCDITSSS
ENVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGY
RIFSVSSPGSVTYDDKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVIN
VFPAEARHIPLYLFVGNIEATYVP----AGPAHLQLASTAAGCLATEPLCGLNDTRVKHS
NKLFFELSNCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1759)

PSIINITPSTGTANELITIIGHGFSSLPCANKV-TIGSYPCVVEESSE
NSIICHIDPQNSMNVGIR

ENSGT00780000121902_0_Linker_9_10 (1759, 1787)

EIVTLIVYNLGTAINTLTKAFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVMPKAGSTT
GMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVP
AQCQSNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYVTGIFPNSIQ-GYGNVLIKGERFGTVLEEISIFIGSQQFRVI
DVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIAGGTTLMI
TGNGFSPGNTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAIIYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKRIIPNR-GLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVG
EHAGGIFPVTMLHKTKGSAVSSVAFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

SIQNIYPTQG-SFGGGQTLTVTGMGFDPWNS
TILVCNSECAVDKLRSNSTTLFCVIPPNNG-KGHDQVCGVSV---VNGKDSSHSTKLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2304)

PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCM
TSVHVPSGWVPVHVNIKNIGLAK

ENSGT00780000121902_0_Linker_15_16 (2304, 2321)

LENADFLYADVWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGSPPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEANIELQAENILITDGGVLQIGTEASPFQHRAVITLH
GHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTLTVQEAVTWKAGD
NIVIASTGHRHSQAENEKRTIASVSADGMHITLTKPLNYTHLGITTTLPDGTVFEARAEV
GILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHA
PLPGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNNEAGIET
KRILAPYVGGWGESNGAVIKNAKIVGHLDELGMGPTFCTSKGLVLPFSQGLTVSSVHFMN
FDRHACVALGVTSITGVCNDRCGGWSAKFVGIRYFHAPNKGGFRWEHEAVLIDVDGSLTG
HRGHTVVPHSSLLDPSHCTQEPAWSIGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVVDMRNGSANPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPI
SGTLDPGVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3308)

WQSSPENN
YTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDK-SEIGVAGPTYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLP
HSVYKTK

ENSGT00780000121902_0_Linker_18_19 (3308, 3472)

LLETAEAGSKILSLVDAVDWQEGEDVVITTTSYDLHQTEIRRIAKILHGHKIL
ILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDDYSVLSKDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFHHSGQEGYRDSTDPRYAVTFLNLGQIQDHGL

PF13229 // ENSGT00780000121902_0_Domain_19 (3472, 3663)

SYVRGCAFH
HVFSPAIGVFGTDGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANSMENWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVNNGMSIFSMVYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLHVSD--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLIDTIEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNSQLGIG
DYRIPKAMLTYLNGSRIPVTEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDS
DTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKKYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKHCELE--R
HLSTEQFLPNLGSTVPGENYFDRTYQMLYLFLKGTTPVEVHTATVIFVSFHLPVMTADEF
FSSHNLVRNLALFLKIPSDKIRVSRIIG-ASLR--KKRST-GHIMEFEIGAAPTQFLSNS
TTGQ--MQLS-ELQEI--TDSLGQAVVLGKISTILGFNISSMSITSPIPQPTDSGWIKVT
AQPVERSA--FPVHYLALVSSLSVVAQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSL
TLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDL---TPHRTGKNYKIEFVLDNTVRV-
----DSRPFSLSAQSVPGGSGSSP-GSG--------------SSSSGHSKASSVGTPVQT
LAVITACLVGRLLLLEVFMAAVFILNTTVGIN----------------------------
-------------

----------------------------MGH-LW--LLEI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQISCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EITMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDTLNVTEKSICCKTPP-KPH-I
LKAVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 452)

GLKLEVWNNSRPIHLEEILEYD

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYIWPMEQDTFVAR
FTGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSSKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPKRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRNTDIQFTYDFAHGN-NWTYTCIDILDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVVYIGQTATISTLDEMPKRRLPALANKGIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEGLRRVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTVLTIVGSGFSPSS---
AISVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSLA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTAGDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVGTI-----LGEVNLTIKGYNFGN
ELTQNVAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIQVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNVTSSS
ENVINCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITIIGHGFSNLTCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVNCRTPAGTTGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNLGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKIKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSVTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHISIAEAKCDVEYSNKTHIICV
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
VLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRL

ENSGT00780000121902_0_Linker_16_17 (2438, 2623)

AHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIAAVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFK

PF13229 // ENSGT00780000121902_0_Domain_17 (2623, 2714)

SYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAG

ENSGT00780000121902_0_Linker_17_18 (2714, 3173)

GTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SENLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNLGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSNVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIIGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-INNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINKGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IYIHRPDISKVNPSDCIDMVCDAKRKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITVL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAEYVSSSSSGSSSSSS-----------SSSGSSSSNSKASTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVSTLKITLRSY----------------------------
-------------

----------------------------MKH-QS--VFAT---LYLLAL-------LLSS
SEHGT-----DGHKTIS

PF01833 // ENSGT00780000121902_0_Domain_1 (78, 169)

KVTEILPKYGSINGATRLTIKGEGFAQANQFNYGVDNELLGNS
VHFVSASRSIPCDVEKDASHSTHITCYTRAMPEDTYSVQVSVDGVSIT

ENSGT00780000121902_0_Linker_1_2 (169, 199)

NDNICRGHINSW
ACSFQT-------KNFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 296)

PTIRSITPLTGLPGSIITIQGRIFTDVYGNNIALSSNG-KNV
RILRVYVGGMPCELLIPQSDNLYGLKLDHENSDMGTMICKITGTYIGKN--VLLYIYAYI
DYSKNFDIKIALRFLEYLVCIYLPFKTN-----------------------PEGTIGEKC
QASIRIETFINLSKNKFFNAFDINLTVLMGRGF----CFQKT--IHYILKKTPKIPPM-I
TRTVYTGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 562)

GLKLEVWNNSRPTHLEEILEYNESTQGYMGDTWVDTASYVWPMEQDMFVAR
FSGFLVAPNSDSYRFYIKGDDRYAVYFSPTGNPE--EKVKIAYHSSYANSYFSSPTQRSD
VFQLQKGKEYYIEILLQEYRQ

ENSGT00780000121902_0_Linker_4_5 (562, 1168)

SAFVDVGLYQHRNFYTEQQTSDSVNEEQVIQAQSVIVPE
VQVITLENWKTTNPKNEIQKITVSSPCMKYNACSFYQYSLIYNKEKT----GLLPADASD
TAMELALNDLLSIQPDVVHVVRT-EGNQSYVYTVTFKSARGDFDLITYEVLEGSHITVEI
AEQTKGIPSLDTFTLTWDGISSKPLTPWSSENEVQAAIEEMVSAKCPKEISHLKEGFAVK
YFKDYETDFSMKHINRGQMTSETEAYCGRYSLKNPAILFDSTDVKPNGMLYGNISLFPYN
QFCLAYKGFLMNNIGLKFQYQDSKSKAIKNTFMQFSFPFIQGS-SWTYTCIDLLYLIQEK
YSGKNFFLQRISLQKASEVQSFYVDVVYLGQTATISNIDEVPKRRLPALANRGIFLKHFE
VKQTKIIGSSATSQYTVTMTSCNCSYRIPLLAVGFAQVITNITENESVYRGMSWPGESQI
RIQRIQAASPPIHGSFDIQAYGHVLK-GLSADISAVDLQYALQSIPEMGQISVIREGNCA
GYSWKIKWRSTCGKQNLLQIKDVNITGEEANV--TVTKITEGGLFRQHILGDLLRTTHEQ
PQVQVYINELPAKCSGNCGYKWDPLST

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1248)

PTILATSPTQGSYDEKTILTISGSGFSSNP---
ATSVTIGSVDCPILSVY--ENEIKCQILTGKAGNFPIAVFVAEMGFA

ENSGT00780000121902_0_Linker_5_6 (1248, 1264)

DHSGG-EMFNFTY
NIQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1342)

ILHIWPASGSLE-GGTLLTLSGFGFAEDSKILVGNKSCNVIKGNLNEIKCRTPKGAE
GTFDVTVMTNGLYASANSAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNISQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PTIMNFSPKTRVL-QVAIIGKVNLTIKGYNFGN
EHSQNM-VYVGRTNCTILHWNFTDI-TCLLPKL-------SPGNYDICVEVG

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASP-
SEELNVSIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1512)

QVTNVFPQKGSLYGGTE-ITLMGFGFSTTPEENSVFFGSFPCNVTSSS
ENNITCILHST

ENSGT00780000121902_0_Linker_8_9 (1512, 1693)

KNVFRVTNQGEDSVYGKGYAWSPSVLNISVGDMVIWQWQAQPFIRGIGY
RVFSVSSPGNVIYDGKGFTSGNQKTTSGSFSYQFTSPGIYYYSSGFINEAQSIFLQGVIN
VLPAKNKYIPLHLFISGTEATYAQ----GVSNESSMSISVAECIAEESSYIQNKTVVKNL
NGIFFELSSCYS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1767)

PSISNISPSYGTVNEAITITGHHFNSLGYANKV-TIGGYPCVIESSSE
NVIICYIDPQNSMAIGVGELVTLIVD

ENSGT00780000121902_0_Linker_9_10 (1767, 1787)

NLGTAINTLTRELDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PHIDTVTPHVGSTR
GMTRVIIKGSGFAASSTHIKAAIGGFPCTILSVNYTVIECETSPAPEQRMDIDLRIHDIP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDNIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1955)

PFVTGIFPNTLQNVSTKFLIEGRGFGECLEDVLVYIGDRQFRAV
YVNDTNISVVVNAMPAGYYLLRVVVMTKGLAAGN

ENSGT00780000121902_0_Linker_11_12 (1955, 1960)

FTVNS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PLVASLLPTSGSTQGGTALII
TGNGFSPANTTVTIGNQLCKIVSITPSEIHCNTPASSPATVEVRILINSFASPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YS
QDDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2113)

PYLKDVLPDR-GPPGTEIEIIGSSFGFDVSEVMVTTDDIQCNITMVNDSVLRCRVG
NHAGGIFPVMLR

ENSGT00780000121902_0_Linker_13_14 (2113, 2130)

HLTRGYAVSRIAFEHSL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQNLFPRQG-SFGGGLTMTVIGSGFNPQNS
MVSVCNTECEVNRPQSDYNTLFCKVPFNNG-SETQKDCEVRI---ANGEYSIQSNTTFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MASLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2300)

PVITDVTPKRGGTEGGTRLTIKGSGFSSNMEDIHVTIGQAVCDVKSTNETHIICI
TNAHSPSQWVKIYVSVGSN

ENSGT00780000121902_0_Linker_15_16 (2300, 2320)

GIAKLDNADFLYIDVWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2439)

SWGGQSPPEEGSLVVITKGQI
ILLDQSTPVLKMLLIQGGSLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPIPVTWTRLAQTAEAGESTLVLQEAVTWNVGD
EIVIATTGHRHSQKENEKKTIASISDDGMSIKLTSSLKYTHLGKTITLPDGTLFEARAEV
GVLTRNILVRGSNNIEWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PEPSADLVIGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLKFRSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDPNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTIPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNDDAGIET
KRILATYVGGWGEINGALIKNAKIVGHLDELGLGPSYCTSKGLLLPFNEGLTVSSVYFMN
FDRPNCVALGVTSILGICNDACGGWSARFIDIQYFHAPNKAGFRWEHEVVLIDVDGSLTE
HKGHSVVPHSSLLDLTHCKQETEWSIGFPGSVCDSSVSFHRLAFNKPSPVSLLEKDVILS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVEHITNISYASTFYGFKDEDYVI
ISHNFTQKADMFNIIDMRNGSSNPLDLNTSRSGDWHLEKNTSTLYYLVSGRNYLSSNQAT
SRTLDPGVKDVIVNFQAYCCFFQDCIPLDSPIRIPPPRKRPEIYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSPENN
YSIPQEGANVVIPEGTWMVVDIDIPSLERLIILGVLELEDHKNNVSTGKPIYRKVVLNAT
YISVQGGRLIGGWEGNPFKGELQIILRGSHSTPEWSLPNGPNQGSKVLGIFGELDLHGIT
RTVYKTKLSETTLAGSRVISLMDAVDWEVGEDIVITTTSYDSRQTETRKIIQILADQRSF
ILNDSLSYTHIAERYQIQSTGQNYTLAADVGILSRNIKIIGENYPGLFKESFGARVLVSS
FTENVVTYKGNAR-ISNVEFYHSGQEGYRDNTDPRYSLAFLNLGQVQENGSSYVRGCSFH
NGFAPAIGVFGTSGLDIEDNIIHLTVGEGLK-IWGN-GNHVRRNLVAFSVWPGTYQNRKE
LTSTLWHAAIEINMDINTVLQDNVVAGFERIGYHINGESCSDQTNSAEKWHNNEAHGGLY
GVYMNQDGFPGCSHI-----QGFTVWKCWDYGIYFQ----------------TTESVQVS
NVTLVDNGMGILPIVYLPAATSHKISSKTVLIKNLLIVGSSPQFNCSDVLTNDDPNIELT
AAHRSARPP--------------------SGQGGRSGICWPTFASAHNMAPRKPHAGLMS
YNAINGLLEVSDS--TFVGFKSVCSDETAVMFMTNPLNEDLQHPIHVKNIQTVNTTEQSK
IFIHRPDLSKVNPSDCVDMVCDAKKKAFLKDIDGSFLGRPGSVIPHAEYEWNGNNQLGVG
DYRIPKVMLTYLNGSKIPISEKAPYKGIVRDSTCKYISEWQSYQCFGMEYAMMVIESLDS
DTEIRRLSPVAVFADGYVDLIN--GPQDHGWCAGYTCQKRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVEQNKAVRVAIFFSTLQRLDVYVNNSLVCPKNTVWNHQQKDCEFN--I
HLPTRGYLPSPNSAVSGENYFDRTYQMLYLLVKGSTPVEVHTTAVLFISFKLPAMTEDHF
YSSRNLVRNLASFLKIPANKIRITKIIRENG--RRKKRMA-VINIELEIGEPPTQILSNH
TTG--QMQLS-ELQEI--SSCLGQAIILGKINSVLGFNISSMSISNPLPNPNDSGWIHVT
AQPVERSA--FPINHLALVSSLSVITQPVAGLPGHLFSQQPSIKAIDSDGNCVSVGITSL
TLKAILKDASNNQVSGLSGNTTVPFSSCWANYTDL---TLIKTGKNYKIEFVLNDVRVE-
-----SRSFSLPVQSSSSSSD---------------------------SKSLNMDSTAQK
VTIVVGCLLGGRLLLELFMTAILILKGIIGKV----------------------------
-------------

----------------------------MGH-LW--LLET---WVFWGL-------LLRA
ADSHT-----GGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSINGATRLTIRGEGFSQENQFNYGVDNAELGNS
VQLVSSFQSISCDVEKDASHSTHITCYTRAMPEGSYTVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GIPIAENNTCKGHISSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGPPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLTLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSFPEQMA-YFVSSLNKI-SMFQTY-----------------------AEITSVSPS
KGSIQGDTMLT-ISGRFFDQTDFPVKVLVGEKKNERWCSILHIPGHQI--KLGP-NKE-Q
IEKVPLGGRGLKLEVWNNSRPVHLEEILGYNEKTPGYLGAHWVDSAS

PF07691 // ENSGT00780000121902_0_Domain_4 (468, 557)

HVWPMEQDTFVAR
FSGFLVPPDSDFYRFYIKGDDRYAIYFSQTGLPEG-DKVRIAYHSANANSYFSSPTQRSD
DIYLQKGREYYIEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFVDVGLYQYKNVYTEQQTGDAINEEQVIKSQSTIIQE
IQVVTLEHWETASAANEVQQIVITSPCVEANSCSQYQYRLIYNMEKT----ALIPADATD
FILQSALNDLWSIKPDKVQVMRT-QNSQSFIYMITFISTRGDFELLDYEVLEGNNVTLYI
TEQIKGKPSMETFTLNWDGIASKPLTPWPSADDFQVAVEEMVSAKCPPQIANFEEGFAVK
YFRDYETDFNLEQINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRIPYGDLSLFPYN
QLCFAYKGFLANFIGLKFQFQDN-GRITRSTDTQFPYKFAYGN-TWTYTCIDLLDLIQAK
YTGTNFALQRIHLQKASESHSFFVDIVYIGQTATISTSDEMPKRRLPALANKGIFFKHFQ
VNQIKVNGSTMTSQYSVTMTSYNCSYDIPLMAVSFGQIISNETENESVYRGNNWPGESKI
RIQRIQEASPPISGSFDIQAYGQILK-GLPAAVSAADLQFALQHLEEMGRVSVTREGTCA
GYSWNIKWKSACGKQNLLQINDSNIIGEKANM--TVTKIKDGGLFRQRILGDLLRTPNQQ
PQVEVYVNGIPAKCSGDCGFTWDPIAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLASSPSQGSYEEGTILTIAGSGFSPSS---
AVSVSVGPVACSLLSVD-EENEIKCKILNGSAGQMPIAVSVA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAHNVGG-EAFHFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QVSHIWPDSGSLA-GGTLLTLSGSGFHENSTVLVGNGTCDVIEGDVNRIICRTPKRIE
GIVDISVITNGYQTLEKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1434)

PVITDFSPKVRTI-----RGEVNLTIKGYNFGN
ELTQKVAVYVGGKPCLVLHWNFTDI-RCLLPPL-------SPGKHDIQVEVRN

ENSGT00780000121902_0_Linker_7_8 (1434, 1453)

WGFAST-
RDKLNASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTNMFPQKGSVYGGTE-ITVLGFGFSMIPAENTVLLGPFPCNVTSSS
DNVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNVFSITNSGEDSVHGSGYAWSPSVLNISVGDTVTWHWQAHPFLRGVGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGVHYYSSGYVDEAHSIFLQGVIN
VLPAETRHVPLHLFVGHTEATYAP----GGPENLHWGSSVTGCLATEPLCGLNNSRVKNS
NRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1755)

PSISNITPSTGTVNELITITGHGFSNLTCANKVVTIGRHPCVVEKSSD
NSIVCRIDPQNSMD

ENSGT00780000121902_0_Linker_9_10 (1755, 1787)

VGIREIITLTVYNLGTAINTLPNEFDRHFVLM

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1869)

PNIDMVVPKAGSTT
GKTRVTIKGSGFGESSAGVEVLMGHFPCKILAVNYTTIECETSPAPQQLVRVDLLVHGVP
AQCQGKCS

ENSGT00780000121902_0_Linker_10_11 (1869, 1877)

FSYLESVT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PSITGIFPNSIK-GSAEVLIEGGGFGTLLGEIAVFIGNQQFRAI
EVNENNITVLVTPLPAGLHPLSVVVGTKGLAVG

ENSGT00780000121902_0_Linker_11_12 (1954, 1960)

NLTLSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2031)

PAVASVSPTSGSVGGGTTLTI
TGNGFYPGNTTVIVGRDPCRIISVNSSHVYCHTPAGTAGTVGVKILVNTV

ENSGT00780000121902_0_Linker_12_13 (2031, 2045)

TYPTWSFTYA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGITPSR-GPSGTEIEITGSNFGTDILELSVLINSIQCNVTMVNDSVLRCIVG
DHAGGTFPVMMHHETKGSALSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2131)

YPLD

PF01833 // ENSGT00780000121902_0_Domain_14 (2131, 2220)

IQDIHPHQG-SFGGGQTLMMTGTGFNPQNS
IVLVCGSECAVDRLSSNYTTLLCKIPPNNG-SGPEQACEVSV---VNGKDSSQSRTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLIDEIAPRRGSTAGGTRLTVTGSGFSENMQDVHITIGEALCDVEYSNKTHIICI
TNAHRPSGWAPIRVNIRNMGLARLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2320)

FLYVDVWSSNY

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2439)

SWGGETPPEEGSFVVITKGQT
ILLDQSTPILKMVLIQGGTLMFDEADIELQAENILITDGGTLQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPIPVIWTLLARTAKAGEQTLILQEAVTWKAGD
NIVIASTGHRHSQQENEKRTIAAVSSDGITITLTNPLNYTHLGVAVTLPDGTLFEARAEV
GILTRNILIRGSDNIEWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPSTNMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLHFKSYVRGCAIHQTYNRAITI
HNTHHLLVERNVIYDVKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDQNICQKRVPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSIVPEPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGEAHGAVIKNAKIVGHLDELGMGSTFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNERCGGWSAKFVDVQYFHTPNKAGFRWEHEVVLMDLDGSLTG
HKGHTVIPHSPLLDPSHCTQEAEWSIGFPGSVCDTSVSFHRLAFNKAAPSSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRSDLHQSQPI
SGTLDPDVKDVIINFQAYCCILQDCFPVHPPSRKSVPRRRPAMYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSQENN
YTVPGPGANVVIPEGTWIVADTDMPPMERLAIWGVLELEDI-YYAGGTKSSHRKVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSSPEWALPNGPNQGAKVLGVFGELDLHGIP
RSIYKTKLSETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRRIIKILHDHKVL
ILNDSLSYTHLAERYHVPGTGQSYTLAADVGILSRNIKIVGEDYPGWSKDSFGAHVLVGS
FTENMMTFTGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQLQEHGLSYVRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVVLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSGQDNPMEKWFNNEAHGGLY
GIYMNQDGQPRCSLI-----QGFTIWACWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYTPAAISHKISSKKVQIQNSLIVGSSPEFNCSDVLTNDDPNIELT
ASHRSSRPL---------------------SEGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGRLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIYVKNIQLVDTIEQSK
IFIHRPDISKVNPSDCIDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNRQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKFIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLINDLGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNEAVLVGIFFSTLQRLDVYVSNSLVCPKNTIWNTQQKYCEPH--G
RLHTEQFLPNLDSTVLGENYFDRIYQMLYLLVKGTTPVEIHTTKVIFVSFQLPFLTDDDF
YSSHNLVRNLALFLKIPSNKIRISKIIRGENLR--RKRSM-GLTIELEIGDPPTQFLNND
TTGQ--MRLS-ELQEI--ASSLGQAVILGKTSSIFGFNISSMSITSPIPSPSDSGWSKVT
AQPVERSV--FPVHHVAFVSSLSVITQPVAAQPGQPFSQQPSVKAVDSDGACVSVGITSL
TLKAILKDSNNNQVK-LVGNTTIPFSSCWPTIQTYSSEDRLRNGKNYKIEFILDNVVRV-
----ESGTFSLPAQTAS------------------------------SGKASTVGPSAQI
MTVVICCLTGRFLLLEIFMASIFILNRSICKY----------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 426)

EVTMIFPS
QGSIRGGTTLT-ISGRFFDQTDFPVRVLVGGEP----CDILNVTENSICCKTPP-KPP-I
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 456)

PGGRGLKLEVWNNSRPVRLEEILEYNEKTP

PF07691 // ENSGT00780000121902_0_Domain_4 (456, 558)

GYMGASWVDSASYIWLMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVIRT-QIPQSYVYMVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDTQFTYTFAYGN-NWTYTCIDLLDLVRTK
YTGTNISLQRISLHKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
RIRRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLEGMGRISVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHVLGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSNIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCSLLSVD-E-KELKCQILNGSAGHAPVAVSMA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAY----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1761)

PSISNITPSTGTVNELITIIGHGFSNLPCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGIRET

ENSGT00780000121902_0_Linker_9_10 (1761, 1787)

VTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFTCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAMSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVVGSGFSENIEDVHITIAEAKCDVEYSNKTHIICM
TDAHTLSGWAPVCVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGIGSAFCTAKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYSRTMNKAGFRWEHEMVMIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHLSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPASRKPIPKKRPVTYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKLSETALAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHFAEKYHVPGTGESYMLAADVGILSRNIKIVGEDYPGWSEDSFGAHVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIIIFWFK-LPSFRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKSVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMIVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLPVATEDDF
YTSHNLVKNLALFLKIPSDKIRISK-IRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVGV-
----ESRTFSLLAESVSSSGSSSSSSSS-----------S-GSSSSSNSNASTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVSTLNITLSKYSPL---IHYFSTC---------------
-------------

----------------------------MGR-LW--LWGT---WGFWGL-------LLCA
ADPRS-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 175)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDDAELGNT
VQLVSSFRSISCDVEKDASHSTHITCYTRAMPEDSYTVRVSVDGVPVTENNTCR

ENSGT00780000121902_0_Linker_1_2 (175, 199)

GLIHSR
ACSFYA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNTARSSNG-KNV
RILRVYIGGMPCELLIPQSDDLYGLKLDHPSGDMGSMICKTTGTYIG--HHNVSFILD-N
DYGRSFPEKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 450)

AEITMISPS
QGSIQGGTTLI-ISGRFFDQTDFPVRVLVGGQA----CDVLNVTENTIYCKTSP-KPD-S
LRTIHPGGRGLKLEVWNNSRPVHLEEILEYNEKTPGYMGASWVDSASYVWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPED--KIRIAYHSSNANSYFSSPTQRSD
DIHLQKGKEYYIEILLQEYRLSAFVDVGLYQYGNVYTEQQTEDAVNEEQVIQSQSAIVQE
VQVITLENWETTNAIKEVQRITVTSPCIEVSSCSLYQYRLTYNMEKT----ALLPADASD
FLLQSALNDLWSLKPDTVQVTRT-QNPQSYVYTVTFISTRGDFDLLGYEVFEGYNVTLDI
IEQTKGKPSLDTFTLNWDGITSKPLTPWSAEAEFQAAVEEMVSAKCPPQIADFEEGFVVK
YFRDYENDFNMDHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDISLFPYN
QLCLAYKGFLADYIGLKFQYQDK-SKITRSTDVQFTYSFAYGN-NWTYTCIDLLDLIQTK
YTGTNFSLQRISVQKASESQSFYVDIVYIGQTPTISIWDEMPKRRLPALANKGIFLKHFQ
VNQTKSNGSSMTSQYSVTMTSYNCSYNIPMMAVSFGQVITNETENESVYRGNNWPGESRI
RIQRIQAASAPLSGSFDIQAYGHVLK-GLPAAVSAADLQFALQSLEGVGRVSVTREGTCA
GYSWNIKWRSACGKQALLQVNDSNIIGEMANM--TVTKVKEGGLFRQRILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDPMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1258)

PIIRTISPSKGSSEEGTILTISGSGFSPSS---
AVSVSVGPIGCSLLSV--NENEIKCQILNGSAGHFPVAVSIADVGLARNVED-KEFH

ENSGT00780000121902_0_Linker_5_6 (1258, 1262)

FMY
Q

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

SQIAHIWPVSGSLA-GGNLLTLSGTGFNENSKVLVGNETCNVIDGDLNKITCRTPKRIE
GTVDISVITNGFQATAKDAYS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1446)

PVITDFIPRVRTI-----LGERNLTIKGYNFGT
DLKQSMEVYVGGKPCQILHWNFTKI-RCLLPTL-------SPGKHDIHVEVRNWGFASTS
RDKLN

ENSGT00780000121902_0_Linker_7_8 (1446, 1452)

ASIQYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVNNVFPQRGSLYGGTE-ITIMGLGFSTIPTENTVLLGSFPCSVSSST
SDVIKCTLPSTGNVFRITNDGEDSVHGLGYAWSPSVLNVSVGDTVTWHWQAHPFLTGIGY
RVFSVSSPGSVTYDGKGFMNGREKSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGINYYSSGYVDEAHSIVLQGVIN
VLPAESRHITLHLSVGSTEATYAQ----GEPVNLHVGSSVTGCLATEALCGLNNTGVKNS
DKLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1779)

PSISNISPSTGTVNELITITGHGFSNLTCANKV-TIGSYPCVVEESSA
NSIVCHIDPQNSMDVGIREIVTLTVYNLGIAINTLPNE

ENSGT00780000121902_0_Linker_9_10 (1779, 1787)

FDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPNAGSTT
GMTKVTIKGSGFSVSSAAVEVRMGRFPCEVLSVNYTTIECETSPAPHQLVTVQLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSESIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

ASITSISPTSIT-GSVQALIEGEGFGTILEDIAVFIGNQQFRAV
DVTDNNITVLVTPLPAGLHPVSVVVGSKGLALGNLS

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVRPTSGSIGGGTTLVI
TGNGFYPGNTTVTVGDESCQIISVNASEVYCRTPAGAAGRVNVKIFVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
WEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLREIVPST-GPPGTKIEITGSNFGTDILEISVVINNIQCNVTMVNDSVLQCIVG
DHAGGTFPVMMHRETKGSAVSTLVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTIHNIQPTQG-SFGGGQMMTVTGTGFNPQNS
EILVCGSECAVNRLKSDYTALLCKIPPNNG-RGPEQACEVSV---ANGKDLSRSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITKIAPERGSTAGGTRLTVMGSGFSENTQDVRITIAETKCDVEYSNETCIICM
TNAHTPSGWAPVRVTVGSMGMAKREKADFLYVDAWSSNCSWGGEPPPEEGSLVVIPKGQT
VLLDQNTPVLKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGVLDLHGLPVPVVWTRLAHTAQAGERTLILQEAVTWKPGD
KIVVASTGHRHSQRENEERTIEFVSADGISITLTHPLNYTHLGITVPLPDGTLFEARAEV
GILTRNILIRGSDNVEWHHKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HHTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSYDRNICQKRIPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYESGIET
KRILGAYIGGWGETNGAVIKNAKIVGHLDELGMGPAFCTMRGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNERCGGWSAKFADIQYFHTPNKAGFRWEHEVVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSVGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFRKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRNDLPQSQPV
SGNLDPDVKDVIINFQAYCCVLQDCFPVHPPSRNPIPRKRPATYNLWSNDSFWQSSRENN
YTIPHPGANVVIPEGTWVVADTDIPPLERLIIWGVLELEDK-HNVEAAESSYRKVVLNAT
YISLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGSKVLGVFGELDLHGLP
RSIYKTKLSETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDIHQTETRSIAKILHGHKIL
ILNEPLSYTHLGERYQVPGTRQSYTLAADVGILSRNIKILGEDYPGWFQESFGARVLISS
FTENMMTFKGNAR-ISDVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQERGSSYIRGCAFH
HGFSPAIGVFGTDGLDIEDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSLSNPLEKWSDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWMCWDYGIYFQ----------------TTESVYIH
NVTLVDNGMAISSMIYMPAAISHQISNKTVQIKSSLIVGSSPEFNCSDLLTNDDPNIELS
AAHRSSRPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDVSG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTIEKAK
IFIHRPDIRKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQSEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDSACRYIPEWQSYRCFGMEYAMMVIESLDS
DTETRRLSPVAIVSSGYVDLINDLGPQDHGWCAGYSCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVKHDKAVLVGIFFSTLQRLDVYVNNALVCPKDTVWNPQQKHCEFN--R
HLHTEQFLPNLNSTVLGENYFDRTYQMLYLLVKGTMPVEIHTTAVIFVSFQIPAVTEEDF
YSSHNLVRNLALFLKIPSDKIRISKVIGGDSVR--KKRSM-GLTVQLEIGDPPPQFITND
TTGQ--MQLS-ELQEV--AASLGQAVILGKTSSTLGFNVSSMSLINPIPSSSDSEWIKVT
AQPVERFA--FLVHHVAVVSSLSVISQPVAAQLGQPLSQQPSVKAVDPDGNCVSVGITSL
TLKAILKDSNNNQISGLGGNTTIPFSSYWANYTDL---TLLRTGKNYKIEFILDNAARV-
----ESRAFSLPAQSVSSGGSSGGGGGGISSGSSSGSSSSSSGSSSGSSGASTVGTAAQT
MTTAISCLMGRVLLLEIFMAAVLTLNINLGKH----------------------------
-------------

----------------------------MGH-LW--LLGT---WGLWAL-------LLRA
ADPHT-----DDSEVI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 165)

PKVMEVLPKYGSINGATRLTIKGEGFSQANQFDFGVDNAELGNS
VQLVSSFRSITCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVDG

ENSGT00780000121902_0_Linker_1_2 (165, 199)

IPIAENNTCKGHINSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIMSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYNGGMPCELLIPQSDNLYGLKLDHPNGDIGSMTCKITGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 426)

EVTTVSPS
KGSTGGGTTLT-ISGRFFDQTDLPVKVLVGGQT----CDILNITENSIYCKTPP-KPP-I
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 444)

PGGRGLKLEVWNNSRPLH

PF07691 // ENSGT00780000121902_0_Domain_4 (444, 558)

LEEILGYNEKTPGYMGASWVDSASYAWPMGQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQFRNVYTEQQTRDAINEEQVIKSQSTIIQE
VQVITLENWETTNATNEVQKITVTSPCVGANSCSFHQYRLIYNMEKT----ILLPADASG
SLMQSALNDLWSVKPDTVQVIRK-RNLQSFIYTITFVSTRGDFDLLGYEVLEGNNVTLDI
TEQTKGKPSLETFTLNWDGIASVPLTPASSEVEFQAAVEEMVSTKCPPQIAHFEEGFVVK
YFRDYETYFDLEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNRSPYGNILLFPYN
QLCLAYKGFLKNYIGLKFQYQDN-GKITRSADIQFTYNFAYGN-NWTYTCIDLLDLIQTK
YEGTDFSLQRISLQKASESQFFYVDVVYIGQTSTISTLVEMPKRRLPALANKGIFLKHFQ
VNQSKINGSTITIQYFIIMTSYNCSHNIPLMAVSFGQVITNETENESVYRGKNWPGKSKI
HIQRIQEASPPISGTFDIYAYGHVLK-GIPAAVSAADLQFALQSLEEVGQVSVTQEGTCA
GYSWSIKWRSTCGRQNLLQVNDSNITGEKANV--TVAKVREGGLFRRHILGDLLRTPSQK
PQVQVYVNGIPSKCSGDCRFTWDPMST

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLISATSPSQGSYEDSTILTIAGSGFSPSS---
AVSVSVGPTSCSLLSVN-E-NEIKCQILNGSAGHVPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DVGLAQNVEG-EGFHFIY
ESR

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1342)

ISHIWPDSGSLA-GGTLLTVSGFGFSENSKVLVGNETCSVTEGNLNKITCRTPKRIE
GTVDISVITNGFQTTAKDVFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PVITDFSPKVRTI-----LGDVNLTIKGYNFGN
ELTQNMVVYVGGKPCQVLHWNFTDI-RCLLPTL-------SPGKHDIHVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNASIWYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

KVTNMFPQRGSLYGGTE-ITVLGFGFSTIPMKNTVLLGSFPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNVFRITNNGEDLVHGLGYAWSPSVLNVSVGDTVTWHWQAHPFLRGIGY
RVFSVSSPGSVIYDGRGFTNGRQKSLSGSFSYQFTSPGIHYYSSGYVDEANSTSLQGVIN
VLPAQTRHIPLHLFVGSTEATYAQ----GGPENLHLESSVAGCLATEPLCGLNNIKVKNS
NRPFFELSSCNS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSTGTVNELITISGHGFSNLTCANKV-TIGSYPCVVEKSSE
NSIMCHIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLIVYNLGTAINTLSKEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PSIDMVLPSAGSTT
GMTRVTIKGSGFSASSAGVEVFMGHFPCKVLTVNYTVIECETSPAPQQLVHVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGIFPNSIE-GSVNVLIEGEGLGTVLEEIAVFIGNQQFRVT
HVNEKNITVLMTSLPAGPHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2036)

PAVASVSPKSGSIGGGTILRI
TGNGFYPGNTTVTVGERPCQIVFVNSSEVYCSTPPGRAGKVDLKIFVNAITYPSL

ENSGT00780000121902_0_Linker_12_13 (2036, 2045)

SFNYS
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPDR-GLPGTEIEITGSNFGFDISEISVMLGDIQCNVTTVNDSMLQCVTG
AHAGGTFPVLMHHKTKGSAVSTVEFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQNIHPTQG-SFGGGRTMTVTGTGFNSQNS
IVLVCGSECAIDRLRSDYTTLLCEIPPHDG-RGPEQACEVSV---VNGKDSSLSVTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MTSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITEISPRRGSTAGGTRLTVRGSGFSENTQDVHITIAEARCNVEFSNRTHIFCT
TEAHTPSGWAPVHVNIRDIGRATLDNADFL

ENSGT00780000121902_0_Linker_15_16 (2311, 2321)

YVDAWSSNYS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLAIITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGTLQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGVLDLHGLPVSVVWTRLAHTAKAGERILILQEAVTWKEGD
KIVIASTGHRHSQRENEERTIESVSTDGKNITITNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNIEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDEFGGCIMFHA
PLPDSNMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSYDQNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSSVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYIGGWGETNGAVIKSAKIVGHLDELGMGSAFCTSKGLVLPFSEGLTVSSLHFMN
FDRPNCVALGVTSITGVCNDRCGGWSAKFVDIQYFYTPNKAGFRWEHEAVLIDVDGSLTG
HKGYTVIPHSSLLDPSHCIQEDQWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVDHVTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRRDLHPIEPI
SGTLDPDVKDVTINFQAYCCILQDCFPVHPPSRTPTPRKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTIPYPGANVVIPEGTWIVADTDMPPMERLIIWGVLELEDK-SNAGPAGPSYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELQIILRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGHP
HSIYRTKLSETAEAGSKVLSLAEAVDWQEGEEIVITTTSYDLHQTETRSIVKILHGNKIL
ILNDTLAYTHLAERYQVPGTDQSYSLAADVGILTRNIKIIGEDYPGWIKDSFGARILVSS
FTGNMMTFKGNAR-ISNVEFYHSGQDGYRDSTDPRYAVTFLNLGQIEDHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSIWPGTYQNRKD
LSSTLWHAAIEINKGTNTVLQNNVVAGFGRAGYRIDGEPCSRKSNPMENWFGNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVRIY
NVTLVDNGMAIFSMIYMPAAVSHKISSKTVQVKSSLIVGSSPEFNCSDVLTNDDPNIELT
AAHRSSRPP--------------------S--GGRSGICWPTFASAHNMSPRKPHAGIMS
YNAISGLLDVSD--STFIGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTIEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLKDIDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFLNGSRIPITEKAPYKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDT
DTETRRLSPVAIISSGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDQNKAVLVGIFYSTLQRLDVYVNNSLVCPKNTVWNTQQKYCKLN--K
HLHTEQFLPHLDSTVLGENYFDRTYQMLYLLVKGNIPVEIYTATVIFVSFQLPAITEDDF
YSSHNLVRNLVLFLKIPSDKIRVSKILRGENMR--RKRST-GGTIELEIGDPPTQFLSND
TTGQ--MQLY-ELQEI--ASSLGKATILGKTSSILGFNISSMSITNPIPSPKDPGWIKVT
AKPVERSA--FPVHHVAFVSSLLVIAQPVAAQPGQPFSQQPSVKAVDSDGNCVSVGITSL
TLKAMLKDSSNNLISGLSGNTTIPFSSCWANYTDL--T-PLRTGKNFKIEFLLDNVARV-
----ESRTFSLLAQLVPGGSGSSTSSGG---------S---GSSSSSSSTTSAMATSAQL
LTIVISFLMGRMLFLEIFMASVFLN-VTIGSNY---------------------------
-------------

-------------------------MGHL----W--LSGT---WFLSGL-------LVCA
ADPGT-----DGPETT

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 172)

PKVTEVIPKYGSVNGATRLTIKGEGFSQANQFNYGADNPALGNH
VQLVSSLQSITCDVEKDSSHSTQITCYTRAMPEDTYTVRVSVDGVPIAEKN

ENSGT00780000121902_0_Linker_1_2 (172, 199)

TCKGLTSSR
ACSFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-RNV
RILRVYIGGMPCELLHPHSDDLYGLRLDQPNGDIGSVTCKTTGTYIG--HHNVSFILD-S
DYGRSFPEKTT-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNKI-SMFQTY-----------------------AE

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 435)

VTMTSPS
KGSTQGGTALT-IHGRFFDQTDLPVRVLVGGQA----CDILNVTENTIYCKTPP-RPE-I
LKTLYPGGRGLKLEVWNNSRPVHLEEIFEYNEHTPGYMGASWLDSASYVWPMEQDTFVARFSGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRPE--DKVRIAYHSANANSYYSSSTQRSDEIYLQKGKAYYIEILLQEYTLSAFVDVGLYQYNNVFTEQQTGDAVNEEQVIKSQSTVIPEVQIITLENWETTNATHEIQQVAVSSPCVGTNSCSLSQYRFIYNMEKT----VWLPADASDFTLQSALNELWSIKPDSVQVTSE-RDLQRSIYTVTFMSTRGDFDLLGYEVFEGNNVTLDITEQTRGKPSLETFTLNWDGIASTPLAPESSEAEFQEAVQEMVSAKCAPEISNLEEGFLVKYFRDYETDFDLDHINRGQKSSETDAYCGRYSLKNPAVLFDSADVKPNKLPYGDILLFPYNQLCLAYKGSLANYLGLKFKYQDS-GNVIRSADMQFEYNFSSGN-QWTYTCIDLLDFLQTKYAGTSFSLQRISLQKSSEFQPIYVDAVYIGQTPTVSALGEMPKRRPPALANKGIFLKYFQVNKTKVNGSAMGIQYSVSMTSYNCSHNIPMMAVSFAQIITNETKDESVYRGNNWPGESKIRIQKIHEASPPISGSFDIQAYGHTLK-GILAAVSASDLQFALQSLEDIGRVSVRREGTCAGHTWTIEWKSPCGRQPLLQINDSNIIGEKANV--TVTRTKEGGLFRQRIPGDMLRTPNQQPQVEVYVNGIPAKCSGDCGFTWDPMTTPLVLTTTPSEGSYAESTILTIAGSGFSSTS---AVSVSVGSTSCSLLSVD-E-NEIKCQILNGSAGHVPVLVSIADAGLAQNLEG-EGSTFVYRSQISHVWPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCNVIEGDLNTITCRTSKRIEGTVDISVITNGIQATAKDSFSYNCLQTPVITDFSPKERAV-----WGDINLAIKGYNFGNELAQNM-VYVGGKACQVLQSNFTDI-SCLLPKL-------PPGKHDIHVNVRNWGLAST-RNKLNASIWYVLEVTHLFPQRGSLYGGTE-LTIKGLGFSTVPTENSVFLGSFPCDITSSSEDVIKCTLHSTGTVFRITNNGSHLEHGLGYAWSPSILNVTVGDTVVWHWQAHPFLRSIGYSVFSISSPGSVTYDGKGFINGRQKSASGSFSYQFTSPGIHYYSSGYVDDIHSISLQGVINVLPAETRRIPLHLFVGNIEATYAP----AGPENLHWTSTAASCLATEPLCGLNDTNAKNPNQLLFELSSCVSPSISNVTPSAGTVNELITISGHGFSSLACANKV-TVGGYPCVVEESSESSIICHIDPQNSMDVGIREIVTLIVYNLGTAINTAPGEFDRRFVLLPNIDMVLPNEGSTTGMTRVTIQGSGFVVSSSNVEVFMGDFPCKVLTVTYTTIECETTPAPQQLALVDLLIHGIPAQCHGNCSFSYLESIAPCVTRVSPNSIK-GSVHVLIEGEGFGTVLEEVSIFIGSQQFRAIEVNENNITALITPLAAGLHSLSVVVGSKGLALGNVTVSSPTLASLSPTSGSIAGGTTLTITGNGFSPGNTTVTVGNKPCQIVFINSSEVYCSTPAGRAGTTNLKISVNEVVYSPLSFTYTMEDTPFLKGIVPNR-GPPGTEVEITGSNLGFDISDVSVMIKDSACNVTSVNDSMLQCIVGEHAGGIFPVTMLHKTKGSALSSVLFEYPLYIQDIYPKQG-SFGGGQTMTVTGTGFDPQNSALLVCGSECAVDKLGSDSKTLFCEIPPNNG-SGPDQACGVSV---VNGKDSSQSTMPFTYTLSLTPLVTEISPRRGSTAGGTRLTVTGSGFSENTRDIHVSIANDQCDVQYSNKTHIICVTSPHVPSGWAPVHISIRNFGMAKVENPDFLYVDVWSSNASWGGKPPPEEGSLAVITEGQIILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHQAVITLHGHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTANAGEWTLIVQEAVTWKAGDSIVIASTGHRHSQGENEKRTIASVSADGMHITLTRPLNYTHLGITVTLPDGTVFEARAEVGILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHAPLPGANMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNICQKRIPLGEFSNNTVHSQGWFGLWIFEEYFPMQTGSCTSTMPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVVVNNYEAGIETKRIVASYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTSKGLVLPFSQGLTVSSVRFMNFDRQDCVALGVTSITGVCNDRCGGWSTKFVDIQYFHAPNKAGFRWEHEAVLIDVDGSLTGHRGHTVIPHSSLLDPSHCTQEAEWSFGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLSDSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFRGAEHLTNISYTSTFYGFKEEDYVIISHNFTQNPDVFNVVDMRNGSSNPLNWNTSKNGDWHLEVNTSTLYYLVSGRSDLPQSQPIPGTLDPDAKDVIINFQAYCCVLQDCFPVHPPSRKPMPRTRPASYNLWSNESFWQSSPENNYTIPHPGANVVIPEGSWIVADTDIPPMEKLIIWGVLELEDR-SEVESATPSYRKVVLNATYISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGLPHSVYKTKLSETAEAGSRILSLMDAVDWQEGEDIVITTTSYDLHQTETRRIAKILHGHKILVLNDTLSYTHLAERQQIPETGQTYTLAADVGLLSRNIKIFGEDYPGWSKDSFGARILVGSLTGNTVTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYSVTFLNLGQLQEHGLSYVRGCAFHHGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVTLSIWPGTYQNRKDLSSTLWHAAIEVNRGTNTVLQNNVVAGFGRVGYRIDGEPCSRQANPMENWFDNEAHGGLYGIYMNQDGLPGCSLI-----RGFTIWTCWDYGIYFQ----------------TTESVHIYNVTLVNNGMGIFPMIYTPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVDLTSAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLDVSG--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLLDTTEQSKVFIHRPDISKVNPSDCVDMVCDAKRKSLLRDMDGSFLGSSGSVIPQAEYEWDGNSRLGIGDYRIPKAMLTFLNGSRIPIAEKAPHKGIIRDSTCKYISAWQSYRCSGMEYAMLVIESLDSDTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKMYEVYFTGTSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKRFCELD--RHLNAEQLLPNLGSTTPGENYFDRNYQTLYILVKGTTPVEVHTATVIFVSFQLPAVTEDDFFSSRNLVRNLALFLKIPNDKIRVSRIIG-VSLR--RKRST-GRVMELEIGAAPTRFLQNSTTGQ--MQLS-ELQEI--SGTLGQAVILGKISTVLGFNISSMSITSPIPQPTDSGWVK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKLEVWNNSRPVHLEEIFEYNEHTPGYMGASWLDSASYVWPMEQDTFVAR
FSGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRPE--DKVRIAYHSANANSYYSSSTQRSD
EIYLQKGKAYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYTLSAFVDVGLYQYNNVFTEQQTGDAVNEEQVIKSQSTVIPE
VQIITLENWETTNATHEIQQVAVSSPCVGTNSCSLSQYRFIYNMEKT----VWLPADASD
FTLQSALNELWSIKPDSVQVTSE-RDLQRSIYTVTFMSTRGDFDLLGYEVFEGNNVTLDI
TEQTRGKPSLETFTLNWDGIASTPLAPESSEAEFQEAVQEMVSAKCAPEISNLEEGFLVK
YFRDYETDFDLDHINRGQKSSETDAYCGRYSLKNPAVLFDSADVKPNKLPYGDILLFPYN
QLCLAYKGSLANYLGLKFKYQDS-GNVIRSADMQFEYNFSSGN-QWTYTCIDLLDFLQTK
YAGTSFSLQRISLQKSSEFQPIYVDAVYIGQTPTVSALGEMPKRRPPALANKGIFLKYFQ
VNKTKVNGSAMGIQYSVSMTSYNCSHNIPMMAVSFAQIITNETKDESVYRGNNWPGESKI
RIQKIHEASPPISGSFDIQAYGHTLK-GILAAVSASDLQFALQSLEDIGRVSVRREGTCA
GHTWTIEWKSPCGRQPLLQINDSNIIGEKANV--TVTRTKEGGLFRQRIPGDMLRTPNQQ
PQVEVYVNGIPAKCSGDCGFTWDPMTTPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1258)

VLTTTPSEGSYAESTILTIAGSGFSSTS---
AVSVSVGSTSCSLLSVD-E-NEIKCQILNGSAGHVPVLVSIADAGLAQNLEG-EGST

ENSGT00780000121902_0_Linker_5_6 (1258, 1263)

FVY
RS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGTLLTVSGFGFSENSTVLVGNETCNVIEGDLNTITCRTSKRIE
GTVDISVITNGIQATAKDSFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITDFSPKERAV-----WGDINLAIKGYNFGN
ELAQNM-VYVGGKACQVLQSNFTDI-SCLLPKL-------PPGKHDIHVNVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1454)

AST-
RNKLNASIWYVLE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHLFPQRGSLYGGTE-LTIKGLGFSTVPTENSVFLGSFPCDITSSS
EDVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFRITNNGSHLEHGLGYAWSPSILNVTVGDTVVWHWQAHPFLRSIGY
SVFSISSPGSVTYDGKGFINGRQKSASGSFSYQFTSPGIHYYSSGYVDDIHSISLQGVIN
VLPAETRRIPLHLFVGNIEATYAP----AGPENLHWTSTAASCLATEPLCGLNDTNAKNP
NQLLFELSSCVS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNVTPSAGTVNELITISGHGFSSLACANKV-TVGGYPCVVEESSE
SSIICHIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLIVYNLGTAINTAPGEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPNEGSTT
GMTRVTIQGSGFVVSSSNVEVFMGDFPCKVLTVTYTTIECETTPAPQQLALVDLLIHGIP
AQCHGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PCVTRVSPNSIK-GSVHVLIEGEGFGTVLEEVSIFIGSQQFRAI
EVNENNITALITPLAAGLHSLSVVVGSKGLALGNV

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PTLASLSPTSGSIAGGTTLTI
TGNGFSPGNTTVTVGNKPCQIVFINSSEVYCSTPAGRAGTTNLKISVNEVVYSPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKGIVPNR-GPPGTEVEITGSNLGFDISDVSVMIKDSACNVTSVNDSMLQCIVG
EHAGGIFPVTMLHKTKGSALSSVLFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

YIQDIYPKQG-SFGGGQTMTVTGTGFDPQNS
ALLVCGSECAVDKLGSDSKTLFCEIPPNNG-SGPDQACGVSV---VNGKDSSQSTMPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLVTEISPRRGSTAGGTRLTVTGSGFSENTRDIHVSIANDQCDVQYSNKTHIICV
TSPHVPSGWAPVHISIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

NFGMAKVENPDFLYVDVWSSNAS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKPPPEEGSLAVITEGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHQAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAHTANAGEWTLIVQEAVTWKAGD
SIVIASTGHRHSQGENEKRTIASVSADGMHITLTRPLNYTHLGITVTLPDGTVFEARAEV
GILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMLHA
PLPGANMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNICQKRIPLGEFSNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTMPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVVVNNYEAGIET
KRIVASYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTSKGLVLPFSQGLTVSSVRFMN
FDRQDCVALGVTSITGVCNDRCGGWSTKFVDIQYFHAPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCTQEAEWSFGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFRGAEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDVFNVVDMRNGSSNPLNWNTSKNGDWHLEVNTSTLYYLVSGRSDLPQSQPI
PGTLDPDAKDVIINFQAYCCVLQDCFPVHPPSRKPMPRTRPASYNLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSPENN
YTIPHPGANVVIPEGSWIVADTDIPPMEKLIIWGVLELEDR-SEVESATPSYRKVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPEGPNQGAKVLGVFGELDLHGLP
HSVYKTKLSETAEAGSRILSLMDAVDWQEGEDIVITTTSYDLHQTETRRIAKILHGHKIL
VLNDTLSYTHLAERQQIPETGQTYTLAADVGLLSRNIKIFGEDYPGWSKDSFGARILVGS
LTGNTVTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYSVTFLNLGQLQEHGLSYVRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVTLSIWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNVVAGFGRVGYRIDGEPCSRQANPMENWFDNEAHGGLY
GIYMNQDGLPGCSLI-----RGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVNNGMGIFPMIYTPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVDLT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDVSG--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLLDTTEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSLLRDMDGSFLGSSGSVIPQAEYEWDGNSRLGIG
DYRIPKAMLTFLNGSRIPIAEKAPHKGIIRDSTCKYISAWQSYRCSGMEYAMLVIESLDS
DTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKMYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKRFCELD--R
HLNAEQLLPNLGSTTPGENYFDRNYQTLYILVKGTTPVEVHTATVIFVSFQLPAVTEDDF
FSSRNLVRNLALFLKIPNDKIRVSRIIG-VSLR--RKRST-GRVMELEIGAAPTRFLQNS
TTGQ--MQLS-ELQEI--SGTLGQAVILGKISTVLGFNISSMSITSPIPQPTDSGWVK--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MEH-LW--LWGT---WGLWGL-------LLCV
AYPH-------GSKVI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 171)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFRSVSCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVDGVPITEN

ENSGT00780000121902_0_Linker_1_2 (171, 199)

NTCKGHINSW
ACSFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 305)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYTGGMPCELLIPQSDDLYGLKLDHPNGDMGSMVCKTTGTYIG--KSRIF------
TFNR

ENSGT00780000121902_0_Linker_2_3 (305, 354)

SFPEKMA-YFVSSLNKI-SMFQTYAGKKNQTFGFVCNIHDILFHVFPLP

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 427)

VTTISPS
RGSIQGGTMLT-ISGRFFDQTDFPVRVLIGGQD----CDVLNVTENSICCKTPP-KPD-I
LRTVYP

ENSGT00780000121902_0_Linker_3_4 (427, 452)

GGRGLKLEVWNNSRPLHLEEILEYN

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYVWPVEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSSNANSYFSSPTQRSD
DIHLQKGNEYYIAILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYRSVYTEQQTEDAVNEEQVIKSQSTTVQE
IQVITLEGWETTSATNEVQKIMVTSPCVEANSCSRYQYRLVYNMEKT----VWLPADASD
FILQSALNDLWSIKPDAVQVVRT-QNPQSYVYVVTFISTRGDFDLLSYEVFEGNNVTLAV
TEQTKGKPSLDTFTLNWDGIMSRPLMPQSSEAEFQAAVEEMVSAKCPPQITNFEEGFVVK
YFRDYETDSNLEHINRGQRTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLAKSIGLKFQYQDT-NKITRSTDRQFTYNFAYGN-NWTYTCIDLLDLIQTK
YTGTSFSLQRINLQKASESQSFYVDITYIGQTATVAALGEMPKRRLPALANKGIFLKHFQ
VNRTKINGSSMTNQYSVTMTSYNCGYNIPMMAVSFGQIIPESTENESVYRGNNWPGESKI
RIQRIQAASPPLSGSFDIQAYRHILK-GIPAAVSAAELQFALQSLEEMGQVSVTREGTCA
GYSWNIKWRSACGKQTLLQINDSNIFGEKANM--TVKMIKEGGLFRQRILGDLLRTPSEQ
PQVEVYVNGIPAKCSGDCGFTWDSSAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PQVWTISPSQGSYEEGTVLTISGSGFSPSS---
AVSVSVGPVGCSLLSVN-E-NEVKCQILHGSAGHFPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAWNVE--EEFRFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1334)

QISHIWPASGSLA-GGTVLTISGFGFNKNSKVLVGNETCSIIEGDLDKITCRTPKRFE
GTVDISVITNGFQ

ENSGT00780000121902_0_Linker_6_7 (1334, 1348)

AMARNVYSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PVITDFNPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMEVYVGGKSCQVLHWNFTDI-RCILPKL-------SPGKHDICVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVSNMFPQRGSLYGGTE-ITIMGLGFSTIPAENTVILGSFPCNVISSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNVFRITNNGEDSVHGLGYAWSPSVLNVSVGDTVTWRWQADPFLRGIGY
RVFSVSSPGSVIYDGRGFTNRREKSASGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGAIN
VLPAETRHIPLHLFVGGTEATYVQ----GGPVNLHLGSSVAGCLATEPLCGLNNARVKNA
DRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1769)

PTVSNISPSTGTLNELITIVGRGFSNLTCANKV-TIGSYPCVVEESSS
HSIVCHIDPQNSMDVGIRELVTVTVYNL

ENSGT00780000121902_0_Linker_9_10 (1769, 1787)

GTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PSIDLVLPNAGSTT
GMTKVTIKGSGFAVSSAGAQVFMGHFPCKVLSVNYTAIECETSPAPQQLVEIELLIHGVP
ARCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1878)

YLESITA

PF01833 // ENSGT00780000121902_0_Domain_11 (1878, 1956)

FITRITPNSIK-ESVKVLIEGEGFGTVLEDIAIFIGNQQFRAI
DVHENNITVLVTSLPAGPHSLRVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2027)

PAVASVTPTSGSIGGGTTLMI
TGNCFYPGNTTVTVGDKPCQIISVSSSEVYCLTPAGT-------IS

ENSGT00780000121902_0_Linker_12_13 (2027, 2045)

VNTVAYPPLSFTYA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRGIVPST-GPPGTEIQITGLNFGVDIPDISVMINSSPCNVTMANDTALQCVIG
EHAGGTFPVTMHHKTKGCAVSAVVFQ

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQNIHPSQG-SFGGGQTMTVRGTGFNPHNS
VILVCGSKCAVDRLKSNYTTLLCEIPPHNGKSGPEQACDVSV---VNGKDVSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLLMT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLITEITPKRGSTAGGTRLRVLGSGFSENIQDVLITVAEAKCDVEYSNKTYIICM
TNAHTPSGWAPVHVNIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2320)

RMGMAKLDNADFLYVDAWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2438)

TWGGKSPPEEGSLVVITKGQT
VLLDQNTPILKMLLIQGGTLIFDEADIELQAENILLTDGGILQIGTEESPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTRLAHTAKAGERTLILQEAVTWKLGD
EIIIASTGHRHSQRENEKRTIASVSADGLSITLTHPLNYTHLGITVTLPDGTLFEARAEI
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPDANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDQNICQKRVPLGEFFNNTVHSQ------
----------GSCTSTVPVPAIFNSLTTWHCQKGAEWVNGGALQFHNFVMVNNDEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKG--------LTVSSVHFMN
FDRPTCVALGVTSITGVCNDRCGGWSAKFVDIQYSHSPNKAGFRWEHEVVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCIQEAEWSRGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DAFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTGKNGDWHLEANTSTLYYLVSGRSDLHQSPPT
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPSSRKPIPRKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTIPYPGANVVIPEGTWIVADIDIPPVERLIIWGVLELEDK-HNMGAAESSYRKVVLNAT
YISLQGGRLIGGWEDSPFKGELQIVLRGTHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
HSIYKTKLSET-----------------EGDEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDTLSYTHFAERYHVPGTSQSYTLAADVGLLSRNIKILGEDYPGWFKESFGARVLVSS
FTDNMVTFKGNAR-ISNVEFYHSGQEGFRDNTDPRYAVTFLNLGQIEEHGSSYIRGCAFH
NGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVTFSVWPGTYQNRKD
RSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSQSNSLGKWFDNEVHGGLY
GIYMNQDGLPGCSLI-----QGFTIWACWDYGIYFQ----------------TTESVRVE
NVTLVDNGMAISSMIYMPPAISHKISSKTVQIKNSLIVGSSPKFNCSDVLTNDDPNIELS
AAHRSSRP----------------------PSGGRGGICWPTFASGHNMAPRKPHAGIMS
YRAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDVSKVNPSDCVDMVCDAKRKSLLRDMDGSFLGNSGAVIPEAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRNSTCEYIPEWQSYRCFGMDYAMMVIESLDS
DTETRRLSPVAIVGGGYVDLIN--GPQDHGWCAGYTCHRRLSLFHSIVALGKSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFPTLQRLDVYVKNALVCPQNTVWNSQQKHCELN--R
HLK-QKFLPNLNSTALGENYFDRTYQMLYLLVKGTVPVEIHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRISKVMRGESLR--RKRSTTELTVELEIGDPPPRFISNN
TAGQ--MQFS-ELQEI--AASLGQAVVLGQTTSILGFNISSMSITNPIPSPSDSGWMKVT
AQPVERFA--FPVHHVAFVSSLSVITQPVATQSGQPFSQQPSVKAMDSDGNCVSVGITSL
TLKAILKDANNNQVSGLSGNTTIPFSCCWANYTDL---TLLRTGKNFKIEFVLDDVIRV-
----ESRTFSLAVQSVTNGSSS-------------------------SSKGSPVGTAAQI
VTTVISCLMGRMLLLEIFTTAVLILNITLVLLIINLHILCFLIQCIFFLIIFRDFNPPCP
-------------

-----------M-------NCSVIISLIFSH-IY--ISRNSFFEELCDL-------TCAI
LLYLS-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PRVTEVMPKYGSVNGATRLTIKGEGFSQANQFNYGVDNADLGNS
VQLVSSFRSITCDVEKDSSHSTQITCYTRPMPEDSYAVRVSVDGVPIA

ENSGT00780000121902_0_Linker_1_2 (169, 199)

ENNTCKGRINSW
ACSFNA-------KNFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPTSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPQSDDLYGLKLDHPSGDVGTVVCKVTGTYVG--HHNVSFILD-S
DYGRSLPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNRI-SMFQTF-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 435)

EVTMISPS
KGSIQGGATLR-INSRFFDQTDLPVTVLVGGQP----CDILNVTEDSICCKTPP-RPH-I
LKTVYPGGRGLKLE

ENSGT00780000121902_0_Linker_3_4 (435, 464)

VWNSSQPEQLEEILGYSENTPGYLGATWV

PF07691 // ENSGT00780000121902_0_Domain_4 (464, 558)

DSASYIWPMEHDTFVAR
FSGFLVAPDSDVYRFYIRGDDRYAVYFSQTGLPE--DKVKIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYKSVYTEQQTGDAVNEEQVIKSQSTVIQE
VQVITLENWETAIATNEVQKIIVTSPCVDTNSCSHYQFRLIYNLEKT----VWLPADASE
VLLQSALNDLWSIKPDTVQVIRV-QSLQHCIYTVTFLSNRGDFDLLAYEVFEGNNVTVDI
EEQTKGKPSLETFTLTWDGILSKPLTPWSSEAEFQVAVEEMVSTKCPPQIAHFEEGFVVK
YFRDYETDFDLENVNRGQKTAESDAYCGRYSLKNPSVLFDSADAKPNRLPYGDILLFPYN
QLCLAYKGFLANHIGLKFQYQDN-GKITRSTERQFMYKFAQEN-SWTYTCLDLLDLIQSK
QTGTDFSLQRISLQKASEMQSFYVDVVYIGQVSTTSTLDEMPKRRLPALASRGIFLKHFQ
VNESKRDESTMTIQYSVTMTSYNCSYNIPLMAVSFGQIITSETENESVYRGNNWPGESKI
RIRRIQEASPPISGSFDIQAYGHILK-GIPADVSVADLRFALQSLEEAGQVSVTREGTCA
GYAWSIKWRSACGKQSLLQINDSNIVGEKANM--TVTKVKEGGLFRQRILGDLFRTPHQQ
PQVEVYINGIPAKCSGDCSFTWDPAAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1249)

PQVLAISPSQGSYEESTLLTIAGSGFSPSS---
AVSVSIGSTNCSLLSVE-E-NEIKCQVLKGSAGRLPVAVSVADVGLAR

ENSGT00780000121902_0_Linker_5_6 (1249, 1264)

TAHS-QGFHFVY
QSG

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1334)

ISHITPDSGSLA-GGTLLTLSGFGFSENSKVLVGNETCDVIEGNLNRITCRTPKRSE
GTVDISVITNGFQ

ENSGT00780000121902_0_Linker_6_7 (1334, 1348)

ATVRNVFRYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVITDFSPKIRTI-----LGDVNLTIKGYNFGN
ELTQNVVVYVGGKVCQILHWNFTDI-RCLLPLL-------SPGEHSVYAEVRNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1453)

FAST-
SDKLNASVQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1512)

EVTDMFPRRGSLYGGTE-ITIMGFGFSTIPAENTVLLGSFPCNVTRSS
ENAIKCTLHST

ENSGT00780000121902_0_Linker_8_9 (1512, 1693)

RNVFRVTNDGSDLVHGLGYAWSPSVLNVSVGDTVIWHWQAPPFLRGVGY
RVFSVSSPGSVTYDGKGFTNGRQKSISGSFSYQFTSPGIHYYSSGYVDEAHSISLQGVVN
VLPAESRHLPLHLFVSSTEATHIQ----GGPENLHLGSSGAGCLATEPLCGPNDTRVQNS
SIFLFELSSCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSTGTANELITITGSGFSNLTCANKV-TIGHYPCVVEESSA
NSITCHIDPQDSMEVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IRELVTLVVYNLGTAINTLSHEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PSIDMVWPNTGSTT
GLTRVIIKGSGFS--WAGVEVFMGHFPCKVLTVNYTAVECETSPAPRQLAQVHLLTRGVP
GLCQGSCSFA

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVSPNTIR-GPVKVLIEGAGFGTVLEEIAVLIGNQQFRAI
DVNENNITVLVSSLPAGLHPLRVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1964)

TVSSPMEA

PF01833 // ENSGT00780000121902_0_Domain_12 (1964, 2039)

SVSPSSGSLGGGTMLVI
TGNGFHPDSTTVTVGEGPCQILFANASEVHCSTPAGRAGKADLQVLVNAVPYPPLPFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRRIAPNI-GPPGTEVEITGSNFGVDISEVSVTISNAGCNVTMVNGSVLRCVAG
DHAGGTFPVLLHHKTKGSGVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIHSIHPEQG-SFGGGQILTVTGVGFNPQDS
VISICSTECATDRLRSDRTTLLCEIPPHDG-VGPDQVCEVRV---VNGKDSSPSTTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PRVTEISPTKGSTAGGTRLTVLGSGFSENPQDVQVTIAEAKCDVEYSNKTHIICV
TNAHTPSGWAPVHVNIRNIGMARQENTY

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDIWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKPPPEEGSLAVITKGQI
LLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGTLQVGTETSPFQHQAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAQTAKAGQWTLILQDPVTWKAGD
AIVIASTGHRHSQQENEKRTIASVSADGVSITLTRPLNYTHLGITVTLPDGSLFEARAEV
GILTRNIIIRGSENVEWNSKIPACPTGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PLPGADVVTGRIEHVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQSYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVRQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMETGSCTSTVPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNHEAGIET
KRILAPYVGGWGETSGAVIKNAKIVGHLDELGMGTGFCTSKGLVLPFSEGLTVSSVQFMN
FDRPNCVALGVTSITGVCHDKCGGWSAKFVDIQYFHTPNKAGFRWEHEAALIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAQWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHTSGWMALIPNANHINWYFRDVDHVTNISYTSTFYGFKEEDYVI
ISHNFTQSPDMFSVIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRSDHHQSQSI
SGTLDPDVKDVVINFQAYCCTLQDCFPVHPPSRKPIPRRRPASYILWSNHSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGAQVVIPEGAWIVADTDLPPMERLIIWGVLELEDK-SSVGASGPSYRRIVLNAT
YISVQGGRLIGGWEDNPFKGELQIILRGNHSTPEWALPEGPNQGAKVLGVFGELDLHGLP
RLIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3469)

SETAEAGSKVLSLMDAVDWQEGDEIVITTTSYDLHQTETRSIVRILHGHKIL
ILNDSLSYNHLAKRYYIPETGQNYILAADVGLLSRNIKIVGEDYPGSSRDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQE

PF13229 // ENSGT00780000121902_0_Domain_19 (3469, 3598)

HSSSYIRGCAFH
HGFSPAIGVFGTDGVDIDDNVIHFTVGEGIR-VWGD-ANRVRRNLVALSVWPGTYQNRKD
SSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQPNPVENWFDNEAHGGLY
GVYMNQDGLPGCSLI-----QGFTIWMCWDYGIYFQ----------------TTERVHIY
NVTLVDNGMAIFSMIYMPPAVSHKISSKTVKVESTLIVGSSPEFNCSDVLRDDDPNIELT
GAHRSAR----------------------PPAGGRSGICWPTFASAHNMAPWKPHAGIMS
YNAISGHLDVSG--STFVGFKNVCSGETNVIFMTNPLNEDLQHPIYVKNIRLVDTTEPSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDLDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPQVMLTFLNGSRIPVSEKAPYKGIIRDATCKYIPEWQSYQCFGMEYAMLVIESLDS
DTETRRLSPVAIVSNGYVDLLN--GPQDHGWCVGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVEHTRAVLVGIFYSTLQRLDVYVNNSLVCPRDTIWNPQQKLCAFN--R
DPRADQFLPKLNSTVLGENYFDRTYQMLYILVKGTTPVEIHTAMVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLNIPSHKIRVSKVIREKSLR--RKRST-GHSIELEIGEPPMRILSND
TTGQ--MKLS-EFQEI--SGSLGQAVILGKISGILGFNISSMSITNPIPSPNDSGWIKVT
AQPVARAA--FPVHHVARVSSLSVVTQPVAGQPGQPFSQQPSVKAVDPEGNCVSVGITSL
TLKAVLKDSSNNQVSGLGGNTTILFSSCWANYTDL---TPLRTGKNYKLEFLLDDVIRA-
----ESRTFSLPVQSVSGDGGSSTSSSS---------S---GGSNGNHSKASAVGTAAQT
VAVLMSCLAGRVLLLEIFMTAAFVLNINVGKHINV---S---------------------
-------------

----------------------------MGH-LW--LLGI---WGLCGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLISSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ECTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 431)

EVTMIFPS
QGSIRGGTTLT-ISGRFFDQTDFPVRVLVGGEP----CDILNVTENSICCKTPP-KPH-I
LKTVYPGGRG

ENSGT00780000121902_0_Linker_3_4 (431, 465)

LKLEVWNNSRPIRLEEILEYNEKTPGYMGASWVD

PF07691 // ENSGT00780000121902_0_Domain_4 (465, 558)

SASYIWLMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYRNVYTEQQTGDAVNEEQVIKSQSTILQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVIRT-QNPQSYVYMVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTLWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDTQFTYNFAYGN-NWTYTCIDLLDLVRTK
YTGTNVSLQRISLHKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNQTKTNGPTMTNQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLEGMGRISVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHVLGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSNIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLAISPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCSLLSVD-E-KELKCQILNGSAGHAPVAVSMA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPFLRGIGY
RIFSVSSPGSVIYDGKGFTSGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGRSEATYAY----GGPENLHLGSSVAGCLATEPLCSLNNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1761)

PSISNITPSTGTVNELITIIGHGFSNLPWANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGIRET

ENSGT00780000121902_0_Linker_9_10 (1761, 1787)

VTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVG
DHAGGTFPVMMHHKTKGSAMSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICM
TDAHTLSGWAPVCVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVTWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKMTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPAPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTAKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDVQYSHTPNKAGFRWEHEMVMIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQLI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTQDWALPEGPNQGAKVLGVFGELDLHGIP
HSIYKTKLSETAFAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSEDSFGARVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKNVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYLPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNLLVCPKTTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDGTYQMLYLLVKGTIPVEIHTATVIFVSFQLSVATEDDF
YTSHNLVKNLALFLKIPSDKIRISK-IRGKSLR--RKRSM-GFIIEIEIGDPPIQFISNG
TTGQ--MQLS-ELQEI--AGSLGQAVILGNISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVGV-
----ESRTFSLLAESVSSSGSS----------------------SSSNSKASTVGTYAQI
MTVVISCLVGRMWLLEIFMAAVSTLNITLRSY----------------------------
-------------

----------------------------MGH-LW--LLGT---LGLWVL-------LLCA
ADPRA-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 170)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFRSISCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVDGVPITE

ENSGT00780000121902_0_Linker_1_2 (170, 199)

SNTCRGRINSW
ECTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PMIKSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 418)

EVTMISPS
RGSTQGGTLLT-ISGRFFDQTDFPVRVLIGGQT----CDILNVTENSIFCKTPP-KP

ENSGT00780000121902_0_Linker_3_4 (418, 429)

E-V
LRTVYPGG

PF07691 // ENSGT00780000121902_0_Domain_4 (429, 557)

RGLKLEIWNNSRPVHLEEILEYNEKTPGYMGAIWVDSASYIWPMEQDTFTAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGHPKDKDKVRIAYHSSNANNYFSSPTQRSD
DIHLQKGKEYYIEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFVDVGLYQYRNVYTEQQTEDAVNEEQVIRSQSTIVQE
VQLITLENWETSSATNEVQKITVTSPCVEANSCSRYQYRLTYNMEKT----VLLPGDASD
FILESALNDLWSIKPDTVQVIRT-QNPQSYVYLVTFISTRGDFDLLGYEVFEGNNVTLDI
TEQIKGKPSLETFTLHWDGVTSKPLTPWSSEAEFQAAVEEMVTTKCPLQIANFEEGFVVK
YFRDYETDFNLEHNNRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIALKFQYQDR-SKITRSNDIQFTYDFTNGN-TWTYTCIDLLDLIQTK
YTGSNFSLRRIGLQKASESQSFYVDTVYIGQASTLSAWDEMPKRRLPALANKGIFLKHFQ
VNHTKINGSSVTNQYSITMTSYNCSYNIPMMAVSFGQIITNETENESVYRGNNWPGKSKI
RIQRIQAASPPLSGSFDIQAYGHILK-GLPATVSATELQFALQSVEKVGRVSVTREGTCA
GYSWNIKWRSSCGKQDLLQINDSHVIGEKANM--TVMKIKEGGLFRQRILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDAMAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVRAISPSQGSYEETTILTILGSGFSPNS---
AVSVSVGPMGCSLLSVDVQESEIKCQILNGSAGRFPVAVSVA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DVGLARNVEG-EVFYFIY
QNR

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1336)

ISHIWPASGSLA-GGTLLTLSGFGFNENSKALVGNETCNVIERDLSKITCRTPKRIE
GTVDISVITDGFRATAKDAYSYNCLQTPVITDFSPKVRTI-----QGKKNFMKHGFFCSC
FLNLNMCKYVGGKPCRIFQWNFTDI-RCLLPKL-------SPGKHDIYVEVRNWGFAST-
RDKLSASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1512)

EVTAMFPQRGSLYGGTE-ITIIGLGFSTIPTENTVLLGSFHCDVTSSS
ENVIKCILHST

ENSGT00780000121902_0_Linker_8_9 (1512, 1693)

GSTFRITNTGEDSVHGLGYGWSPSVLNVSVGDTVIWHWQAHPFLRGIGY
KVFSVSSPGSVIYDGKGFTNGREKSASGSFSYQFTSPGIHYYSSGYVDEARSIFLQGVIN
VLPAETRHIPLHLFVGSTEATYAQVLLPKGPVDLHLGSSVAGCLATEPLCGPNNTRVKNS
DRLVFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PFINNISPSAGTQNELITITGRGFSNLTCANKV-TIGNYPCIVEESSD
NSIRCHIDPQNSMNVGIRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVTVTVYNLGTALNTLSSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNINMVLPNAGSTT
GMTRVTVRGSGFAASPAGVEVFMGHFPCKVLSVNYTAIECETSPAPQQLVKVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1879)

YLESITAF

PF01833 // ENSGT00780000121902_0_Domain_11 (1879, 1951)

VTRVFPNFIK-GPVEVLIEGEGFGTILEDIAVFIGNQQFRAM
DVNENNVTVLVGPLPAGLHSLGVVVGSKGL

ENSGT00780000121902_0_Linker_11_12 (1951, 1960)

ALGNLTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAIASVTPTSGSIAGGTTLLI
TGNGFDPGNTTVTVGYEPCEIISVNSSEVYCCTPAGTAGRVSVKIFVNEVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRELVPNT-GPPGTKIQIIGSNFGIDILEISVKIDNTPCNVTMVNDSVLQCIIG
DHAGGTFPVMMHRKTKGFAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YAL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQNIHPSQG-SFGGGQTMTVTGTGFNPETS
IILVCGSECAIDRLKSDCTRLLCKIPHNDG-RGPEQTCEVSV---VNGKDLSHSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2296)

PLISDIYPKRGSTAGGTRLTITGSGFSENVQDVLITIAEAKCNVEYSNKTYIICM
TSAHSPSGWAPVHVN

ENSGT00780000121902_0_Linker_15_16 (2296, 2320)

IRSLGMAKLDDPDFLYVDAWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2438)

SWGGKSPPEEGSLVVITKGQT
VLLDQNTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHRAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVSVIWTHLAHTAKAASKLFHILQSWQWFPWS
RIVNTSIFYRHSQQENEKRTIASVSADGTNILLTNPLNYTHLGTTVTLPDGTLFEARAEV
GILTRNILIRGSDHVEWSNKIPACPDGFDTGEFTTQTCFQGKFGEETGSDQFGGCIMFHA
PIPSANMVIGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFSSLTTWNCEKGAEWVNGGALQFHNFVMVNNFEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTRKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNERCGGWSAKFVDIQYFHTPNKAGFRWEHEVVLVDVDGSLTG
HRGHTVIPHSSLLDPSHCSQEAEWSIGFPGAVCDTTVSFHRLAFNKPSPVTLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRNDLQQSQPI
SGTLDPDVKDVIINFQAYCCILQDCFPVHPPSRKPIPRKRPSIYNLWSNDS

PF10162 // ENSGT00780000121902_0_Domain_18 (3172, 3309)

FWKSSRENN
YTIPHPGANVVIPEGTWVVADTDIPPMESLTIWGVLELEAK-HSMRAAESSYRKVVLNAT
YISLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3548)

SETAEAGSKVLSLVDAVDWQEGEEIVITTTSYDFHQTETRSIIKILHDQKIL
ILNDTLSYTHLAERYHVPGTGQSYTLAADVGILSRNIKILGEDYPGWFKESFGARVLVSS
FTQDMMTFKGNAR-ISNVEFYHSGQEGFRDNTDPRHAVTFLNLGQIQERGSSYIRGCAFH
NGFSPAIGVFGTDGLDIDNNIIHFTVGEGIR-IWGD-ANRVRGNLVVLSVWPGTYQNKKD
LSSTLWH

PF13229 // ENSGT00780000121902_0_Domain_19 (3548, 3700)

AAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQSNPMEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAISSMIYMPAAVSHKISSKTVQIKSSLIVGSSPGFNCSDVLTNDDPNIELS
AAHRSARPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLEISG--STFVGFKNICAVETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDVSKVNPSDCVDMVCDAKRKSFLRDMDGSFLGDSGSVIPQAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPITEKAPYKGIIRDSTCKYIPQWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLING--RTKYRWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TTPQNLRLMLLNVDHKKAVVVGIFFPTLQRLDVYVNNALVCPRNTVWNPQQKHCELN--R
HLYTEQFLPNLNSTVLGENYFDRIYQMLYLLVKGTTPVEIHTTAVIFVSFQLPAVTEDDF
YISHNLVRNLALFLKIPSDKIRVSKIIQGESLR--RKRSM-GLTVELEIGDPPPQFISND
TAGQ--MQLS-ELQKI--ASSLGQAVILGRTSSIIGFNISSMSITSPIPSTSDSAWIKVT
AQPVERFA--FPVHHVASVSSLSVITQPVAAPPGQAFSQQPSIKAVDSDGNCVSVGITSL
TLKAILKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGKNYKIEFILDDIVRV-
----ESATLSLPAQSISSGSGTSGGGGSS------------DS--NSNSKAPTVGTAAQI
MIIAIICLMGKVLLSEIFMATVLNLNINP-------------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQISCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYDLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDTLNVTEKSICCKTPP-KPH-I
LKAVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 452)

GLKLEVWNNSRPIHLEEILEYD

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYIWPMEQDTFVAR
FTGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSSKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRNTDIQFTYDFAHGN-NWTYTCIDILDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVVYIGQTATISTLDEMPKRRLPSLANKGIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEGSGRVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTVLTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSLA-GGTLLTLSGFGFNENSRVLVGNETCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTAGDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNVAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIHVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITIIGHGFSNLTCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVNCRTPAGTTGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNLGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSVTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHISIAEAKCDVEYSNKTHIICV
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
VLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIAAVTADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPVGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRRNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSNVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIIGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-INNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYRNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IYIHRPDISKVNPSDCIDMVCDAKRKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSGSSSS----------------------SSTSTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVSTLKITLSKYSPL---IQYFSTY---------------
-------------

----------------------------MGH-LW--LRGA---WGLWGL-------LLSA
ADSHTD-----GSKLI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PKVTEVIPKYGSVNGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSIACDVEKDSSHSTQITCYTRAMPEDSYAVRVSVDGVPIG

ENSGT00780000121902_0_Linker_1_2 (169, 199)

ENNTCKGRVNSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNIAPSSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPQSDDLYGLKLDHPNGDMGSMICKITGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 355)

YFVSSLNKI-SMFQTF-----------------------AEV

PF01833 // ENSGT00780000121902_0_Domain_3 (355, 426)

AMVSPS
KGSIQGGATLT-INGRFFDQTDVPVRVLVGGQP----CDILNITENSICCKTPP-RPH-S
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 452)

PGGRGLKLEVWNRSRPAHLEEILGYG

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

ENTPGYMGATWIDSASYTWPMEHDTFVAR
FSGFLVVPDSDVYRFYIRGDDHYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIYLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYKSVYSEQQTGDAINEEQVIKSQSTIIQE
VQVITLENWETTIATNEVQKITVTSPCMDANSCSHYQYRLIYNTEKT----VLLPADASE
VILQSALNDLWSIKPDTVQVIRT-QALQSRIYTITFISNRGDFDLLGYEVFEGNNVTVDI
TEQTKGKPSLETFTLNWDGILSKPLTPRSSEAEFQVAVEEMVSTKCPPQIAHFEEGFVVK
YFRDYETDFDLENVNRGQKTAETDAYCGRYSLKNPSVLFDSADAKSNRLPYGNILLFPYN
QLCLAYKGFLANYIGLKFQYQDS-GKITRSKDTQFIYNFAHGK-SWTYTCLDLLDLIQSK
QTGMNFSLQRISLQKASETQSFYVDVVYIGQVSTTSTLDEMAKRRLPALANKGIFLKQFQ
VNQSKKDESTMTIQYSVTMMSYNCSYNIPMMAVSFGQIIANETENESVYRGNNWPGESKI
RIQRIQEASPPISGSFDIQAYGHVIK-GIPATVSAADLQFALQSLEEVGRVSVTREGTCA
GFSWGITWRSACGKQNLLQINDSNIIGEKANM--TVTKIKEGGLFRQRILGDLLRTPHQQ
TQVEVYINGIPAKCSGDCSFTWDSTAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PQVLAISPSQGSYEESTILSIVGSGFSPSS---
AVSVSVGSTGCSLLSVD-E-NEIKCQIVNGSAGHLPVAVSVA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DVGLAQNVDS-KGFHFIY
QSQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1337)

LSHIWPDSGSLA-GGTVLTLSGFGFSENSEVLVGNETCSVIEGNLNRITCRTPKRSE
GTVDISVITNGFQATS

ENSGT00780000121902_0_Linker_6_7 (1337, 1348)

RNIFRYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVIMDFSPKIRTI-----LGDVNLTIKGYNFGN
ELTQNVVVYVGGKTCQILHWNFTDI-RCLLPEL-------SPGKHSVHVEVRNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1453)

FAST-
SDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTDMSPHRGSLYGGTE-ITIMGLGFSTIPTENTVLLGSFPCNVTSSS
ENTIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGKVFRITNNGEDLVHGLGYAWSPSVLNVSVGDTVAWHWQAHPFLRGIGY
RVFSVPSPGSVSYDDKGFTNGRPKSSSGSFSYQFTLPGIHYYSSGHVDEARSVSLQGVIN
VLPAKTRHLPLQVFVRSTEATYTR----GGPENLHLGSSVAGCLATEPLCSLNDTRVKDS
NIFLFELSSCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1754)

PSISNITPSTGTVNELITITGSGFSNLTCANKV-TIGRYPCVVEESHD
SSITCHIDPQNSM

ENSGT00780000121902_0_Linker_9_10 (1754, 1787)

EVGIRDFVTLVVYNLGTAINTLSSEFDRQFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIEMVLPNTGSTT
GMTRVIIKGSGFAGSSAGVEVLMGHFPCKVLTVNYTAIECETSPAPQQLVLVHLLIRGVP
ALCQGSCNFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PCVTGIFPDSVR-GPVKVVIEGEGFGTVLEEVAVFIGNQQFRAI
HVNESNITVLVPSLPAGLHSLRVVVETKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PMVASVSPTSGSLGGGTMLVI
TGNGFHLDNTTVTVGEAPCQIMFANSSKVHCSTPAGKAGKTNLQILVNEVPYPALSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YS
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGISPNT-GPPGTEIEITGSNFGFNISEISVRISDAGCHVTMVNDSVLQCVAG
DHAGGTFPVVLYHKTKGFAVSTLVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQSIHPQQG-SFGGGQTLTVTGAGFNPQGS
VPLICGSECATDRLRSDYTTLLCEIPPNDG-MGPEQACEVSV---VNGRDSSPSTALFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLVTEISPRKGSTSGGTRLTVWGSGFSENPQDVAITIAEAECDVKYANKTHIICV
TSAHTPSGWAPLHVNIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

NIGMAKLKNADFLYMDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2436)

WGGRSPPEEGSLAVITKGQI
LLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHPRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTQ---TAKAGEWTLILQEGVTWKAGD
SIVIASTGHRHSQRENEERTIASVSADGVNITLTQPLNHTHLGTSVTLPDGTVFEARAEV
GILTRNIVIRGSENVEWNNKIPACPSGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PLPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRNCAIHQSYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDPHICQKRIPLGEFFNNTVHSQGWFGLW
IFEDYFPMKTGSCTSTAPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILASYVGGWSETNGAVVKNAKIVGHLDELGMGSAFCTSKGLVLPFSDGLTVSSVRFMN
FDRPNCVALAVTSITGVCHDKCGGWSAKFVDIQYFHTPNKCGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSLLLDPSHCTQETQWSIGFPGSVCDASVSFHRLAFNKPSPISLLEKDVILS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDVGHITNISYTSTFYGFKEEDYVI
ISHNFTQNPVMFSVIDVRNGSSNPLNWNTSKNGDWHLDANTSTLYYLVSGRHDLQQSQSI
SGTLDPDVKDVVITFQAYCCSLQDCFPVHSPSRKPIPRKRPATYNLWSNHSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGAHIVIPEGTWIVADIDLPPMERLLVWGVLELEDK-SSDGAAEPSYRTVVLNAT
YISVQGGRLIGGWEDNPFRGELHIVLRGNHSTPEWALPGGPNQGAKVLGVFGELDLHGLP
HLIYKTKLSETAEAGSRVLSLTDAVDWKEGEEIVITTTSYDLYQTETRSIVKILHGHKIL
ILNDSLSYNHLAKRHYVPETGQSYILAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYVRGCAFH
HGFSPAIGVFDTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRRNLVTLSVWPGSYQDRKD
LSSTLWHAAIEINKGTNTVLQNNVVAGFGRVGYHIDGEPC--------------------
---------------------GFTIWTCWDYGIYFQVNGIKGVLFHLLFLLQTTEHVHIY
NVTLVDNGMAIFSMIYMPAAVSHKISSKTVKVESTLIVGSSPEFNCSDVLSNDDPNIELT
DAHRSAR----------------------PPAGGRSGICWPTFASAHNMAPRKPHAGIMS
YSAISGGLDVSG--STFVGFKNVCSGETNVIFMTNPLNEDLQHPIYVKNVQLVDTTEPSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDTDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPKAMLTFLNGSRIPVTEKAPYKGIIRDATCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFYSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNRAVLVGIFYSTLQRLDVYVNNSLVCPKNTIWNAEQKRCKLN--M
HLYAEQFLPKLNSTILGENYFDRTYQMLYLLVKGTAPVEIHTAAVIFVSFRLPAVTEDDF
YSSQNLVRNLALFLNIPSDKIRVSKIIRGKSMR--RKRST-GQTIELEIGDPPIQFLSND
TPGW--MKFS-ELQEI--SGSLGQAVILGKISSILGFNISSVSITNPIPSPNDSGWTKVT
AQPVARSA--YPVHHVALVTSLCVITQPVTAQPGQPFPQQPSVKAVDPDGNCVSVGITSL
TLKAVLKDSSNNQISGLGGNTTIPFSSCWANYTDL---TPLRTGKNYKLEFLLDNVVRA-
----ESRTFSLLVQSASGDSSS-TSSSS---------S---GGSGGSHSKASTVGTSAQI
MAILISCLMGRMLLSEILMAAAFILNINVGKYRSF---CM--------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDALNVTENSICCKTPP-KPH-I
FKAVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 452)

GLKLEVWNNSRPIHLEEILEYD

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNTEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLDYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEYINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDIQFTYDFAHGN-NWTYTCIDLLDLIRTK
YTGTNVSLQRISLQKASESQSFYVDLLYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNRTETNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSATDLQFVLQSLEGLGKVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWNSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-GRKEIKCQILNGSAGPAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNATCNMIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVSARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIYVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNITSSS
ENVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNLFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYIDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GEPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PSISNITPSTGTVNELITIIGHGFSNLPCANKV-TIGSYPCVVEESSE
DTITCHIDPQNSMDVGVRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVNVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYLTGVFPNSVT-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVMGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINLNEVDCLTPAGTNGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHITIAEAKCDVEYSNKTHIICM
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTHLARTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTISSVHFMN
FDRPKCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEIVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPKGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIVGEDYPGWSKDSFGARILVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3634)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------VIMIKDVL
FI----------IMFYFS------------------------------------------
------KSE--------------------KFETLISGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLHIFILLSRNN--------E
LNNSTFLLSKVNPSDCVDMVCDAKRKSFLKDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYRCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKYCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKRTIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQVI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHYVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSG----------------------SSSSSSTSTVGTYAQI
MTVVISCLIGRMWLLEILMAAVSTLKITLSKYSPL---IQYFST----------------
-------------

----------------------------MGH-LW--LLGT---WGFWGL-------LLCA
ADPRT-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFRSISCDVEKDSSHSSHITCYTRAMPEDSYTVRVSVDGVPIT

ENSGT00780000121902_0_Linker_1_2 (169, 199)

ENNTCKGHVNSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLIPQSDNLYGLKLDHPNSDMGSMVCKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 417)

VVTTISPS
RGSIQGGTTLT-ISGRFFDQTDFPVRVLVGGQA----CNVLNVTENSIHCKTPP-K

ENSGT00780000121902_0_Linker_3_4 (417, 430)

PD-I
LRTVYPGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 557)

GLKLEVWNNSRPVHLEEILEYNEKTPGYMGASWVDSASYIWPMEQDSFVAR
FSGFLVAPDSDVYRFYIRGDDRYAIYFSQTGIPED--KVRIAYHSSNANNYFSSPTQRSD
DVHLQKGKEYYVEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFVDVGLYQYRNVYTEQQTEDAINEEQLLQSRSTVVQE
VQVITLENWETSNAINEVQKLTVTSPCVEANSCSLYQYRLIYNMEKT----VLLPADASD
FILQSALNDLWSIKPDTVQVIRT-QNPQSYVYLVTFVSTRGDFDLLGYEVFEGNNVTLDI
TEQTKGKPSLDTFTLKWEGINSKPLTPWSSEAEFQAAVEEMVTAKCPPQIANFEEGFVVK
YFRDYETDFNLKHINRGQKTAETDAYCGRSSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDK-SKITRSTERQFTYNFAYGN-NWTYTCIDLLDLIQTK
YTGTSFSLQRISLQKASESQSFYVDIVYIGQTATISTWDEMPKRRLPALANKGIFLKHFQ
VNQTKMNGSSMTNQYSVTMTSYNCSYNIPMMAVSFGEIITNETENESVYRGNNWPGESKI
RIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEEVGQISVTREGTCA
GYSWSIKWRSTCGKQNLLQVNDSNIIGEKANM--TVMRIKEGGLFRRRIIGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDLMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVSATSPSQGSYEESTVLTISGSGFSPSS---
AVSVSVGPVGCSLLSV--DENEIKCQILPGSAGRFQVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVEG-EVFHFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1337)

QISHIWPASGSLA-GGTLLTLSGFGFNENSKVLVGDETCIVIEGDLNKITCRTPKRIE
GTVDISVITNGFHATA

ENSGT00780000121902_0_Linker_6_7 (1337, 1348)

KDAYSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1434)

PVITDFSPKLRTV-----LGEVNLTIKGYNFGN
ELTQNVEVSVGGKPCQVLHWNFTDI-RCLLPEL-------SPGKHNIYVEVRN

ENSGT00780000121902_0_Linker_7_8 (1434, 1453)

WGFAST-
RDKLNASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTNMFPQRGSLYGGTE-ITVVGLGFSTIPNENTVLLGSFPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNVFRITNNGEDSVHGLGYAWSPSVLNVSVGDTVTWRWQAQPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGREKSTSGSFSYQFTSPGIHYYSSGYVDEAQSIFLQGVIN
VLPAETRHIPLHLFVGSTEATYAQ----GGPENLHLASSAAGCLATEPLCGLNNTGVKNG
ERLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PFITNISPSAGTVNELITITGRGFSSLACANKV-TIGSYPCVVEESSN
NSILCHIDPQNSMDVGM

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSDELDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNINMVLPNAGSTT
GMTKVTIKGSGFAVPSAGVEVLMGQFPCKVLSVSYTAIECETSPAPQQLMTVDLLIHGVP
AKCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1950)

PFITRIVPNSIE-ESVEVLIEGEGFGTILEDIAVFIGSQQFKAI
DVNDNNITVLVTPLPAGLHSLSVVVATKG

ENSGT00780000121902_0_Linker_11_12 (1950, 1960)

LALGNLTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVTPTSGSIGGGTTLVI
TGNGFYPGNTTVTVGDDPCQIISINSREVYCRTPAGTAGRVNVKIFVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRGIVPST-GPPGTEIQITGSNFGVDILEVSVMINYIQCNVTMVSDSVLQCIVG
EHAGGTFPVMMHHKTKGSAVSTAVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQNIHPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAVDRLKSDSTTLLCKIPPNNG-KGPEQVCEVSV---VNGQDLSQSVTPFM

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TNDMT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLITKISPKRGSTAGGTRLTVVGSSFSENMQDVLITIAGAKCDVEYSNKTCIICM
TNAHTPSGWAPVHVNIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2320)

SIGMAKPDNANFLYVDAWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2439)

SWGGDSPPEEGSLVVITKGQT
ILLDQNTPILKMLLIQGGTLIFDDADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPIPVIWTRLAQTAKAGESTLILQEAVTWKPGD
TIVIASTGHRHSQRENEKRTIASISPAGINITLTEPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSANVEWNDKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PIPGVNMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPIPARFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPFVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSIHFMN
FDRPNCVALGVTSITGVCNDRCGGWSAKFVDIQYFRTPNKAGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSLLLDPSHCNQEAEWSVGFPGAVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSVVPFQKKRLTHMSGWMALIPNAKHINWYFKGVDQITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLDWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPSSRKPIPRKRPATYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSRENN
YTVPHPGANVVIPEGTWIVADTDIPPMERLIIWGVLELEDK-HNVEAAESSHRKVVLNAT
YIFLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETAQAGSKVLSLMDAVDWQVGEEIVITTTSYDFHQTETRSIIKILHDQKIL
ILNDTLSYTHFAERYHVPGTTQSYTLAADVGILSRNIKILGEDYPGWFKESFGARVLVSS
FTENMMTFKGNAR-LSNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
NGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNVVAGFGRAGFRIDGEPCSSQSNPMEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVQIY
NVTLVDNGMAISSMIYMPAAVSHKISSKTVQIKSSLIVGSSPEFNCSDVLTNDDPNIELS
AAHRSSRPL--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISGNDSTFVGFKNVCSGETNVVFITNPLNEDLQHPIHVKNIQLVDTMEQSK
IFIHRPDVSKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYRCFGMEYAMMVIESLDS
DTETRRLSPVAIMSNGYVDLING--PQDHGWCSGYTCQRRLSLFHSIVALNNSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFPTLQRLDVYVNNTLVCPKNTVWNSQQKHCELN--R
HLHTEHFLPKLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTTAVIFVSFQLPAVTEDDF
YSSPNLVRNLALFLKIPSDKIRVSKIIRGERLR--RKRSM-ALTVELEIGDPPLQFISND
TTGQ--MQLS-ELQEI--AGSLGQAVISGKTSGILGFNISSMSITDPIPSPSDPGWIKVT
AQPVERFA--FPVHHVAFVSSLWVITQPVAAQLGQPFSQQPSVKAVDSDGNCVSVGITSL
TLKAILKDSNNNQISGLGGNTTIPFSSCWANYTDL---TLLRIGKNYKIEFILNNVVRV-
----ESMTFSLPAQSVSSGSSGSGSS----------------SSGSGSSKASTVGTAAQI
MTTIISCLMGRVLLLEIFMAAILILNVNLGSN----------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ANPRT-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAALGNS
VQLVSSFQSIACDVEKDASHSTHITCYTRAMPEGSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 303)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIVRSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTFIG--KSENL---T-F
FL

ENSGT00780000121902_0_Linker_2_3 (303, 353)

NRSLPQKMA-YFVSSLSKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 427)

EVTTIFPS
RGSIQGGTTLT-ISGRFFDQTDFPVRVLV--KL----CDTFNVTENSICCKTPP-KPR-I
LKTVYP

ENSGT00780000121902_0_Linker_3_4 (427, 441)

GGRGLKLEVWNNSH

PF07691 // ENSGT00780000121902_0_Domain_4 (441, 558)

PVHLEEILEYNEKTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPAQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVKRT-QNAQSYIYTITFISTRGDFDLLGYEVFEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQRAVEEMVSTKCPPQITNFEEGFVVK
YFRDYETDFNLERINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDS-SKIIRSTDVQFTYNFAYRN-NWTYTCIDLLDLIRTK
YTGTNISLQRISLQKASESQSFYVDVVYIGHTSTVSTLDEMPKRRLPALANKGIFLEHFQ
VNRTKINGPTMTHQYFVTMTSYNCSYNIPMMAVSFGQIITHKTENEIVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGRILK-GLPTGVSAADLQFALQSLEGMGRVSVTRDGTCA
GYTWSIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSAITPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLGTSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGPVGCYLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFNPKVRTI-----LGEVNLTINGYNFGN
ELTQNMVVYVGGKTCQILHWNFTDI-RCLLPKL-------PPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSIFPQRGSLFGGTE-ITIRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGFVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
ERLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSSGTVNELITIIGHGFSNLPCANKV-TIGSYPCVIEESSD
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNVGSTT
GMTRVTIKGSGFAVSSAGVEVLMGHFPCKILSVNYTAIECETSPAVQQLVDVYLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PYITGISPNSII-ESVKVIIEGEGFGNVLDDIAVFIGNQQFRTI
DVNENNITALVTSLPVGRHSLSVVVGSKGLALG

ENSGT00780000121902_0_Linker_11_12 (1954, 1962)

NLSVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASVSPISGSIGGGTTLLI
TGNGFYPGNTTVTIGDDPCQIISINPNEVYCHTPPRTAGMVGVKIFVNTISYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPSR-GPPGTEIEITGSNFGIEILDISVTINNVQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAISTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIENINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAVDRLRSDYTTLLCEIPSNNG-RGAEQACEVSV---VNGKYLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVFLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVMGSGFSENIEDVHITIAEAKCAVECSNKTHIICM
TDAHPLSGWAPVHVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILLQ----MEIGTETSPFQHKAVITLH
GHLRSPELPVYGAKNTVY----MLALGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGITVTLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSNNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLRFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCISTVPVPARFNSFTAWNCQKGAEWVNGGALQFHNFMMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLYELGMGSAFCTRKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQKAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKDEDYVI
ISHNFTQNPDMFNIIDMRNGSLNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLQQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPMPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGIWIVADIDMPSMERLTIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTRDWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETADAGSKILSLVDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDRKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWSQDSFGAHVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINGGTNTVLQNNVVAGFARAGYRIDGEPCPSQFNPVEMWFDNEAHGGLY
GIYMNQDGFPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTENVYIY
NVTLVDNGMAIFPMIYLPAAISHKISNKKVQIKSSLIVGSSPGFNCSDILTNDDPNVELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGFVIPQAEYEWDGNSQLGIG
DYRIPKVMLTSLNGSKIPVTEKAPHKGIIRDSTCKYIPQWQSYQCFGMEYALMVIESLDP
DTETRRISPVAIMGNGYVDLLN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVDHNKAVVVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--T
LLYKDQFLPNLDSAVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQLPAITEDDF
YTSHNLVRNLALFLKIPNDKIRISKMIREKSLR--RKRSM-GFIIEIEIGDPPIQFLNNG
TTGQ--MKLS-ELQEI--AGSLGQAVILGKISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLSVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSSNNQVSGLSGNTTIPFSSCWANYTDL--T-PLRSGKNYKIEFILDNVVRV-
----ESRTFSLQAESVSSSSSSSGSSSS---------SSSSGGSSSSNSKASTVGTSAQI
MTVVISCLIGRMWLLEIFMAAVRL------------------------------------
-------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------G

PF10162 // ENSGT00780000121902_0_Domain_18 (3196, 3309)

IWLVVDSEMPPMGKLTIFGVLELEENKNNFRAKNTTYGKVVLNAT
YISVQGGRLIGGWEERPFKGELEILLRGSHSTPDWTLSEELNQGSKVLGVFGELDLHGIP
HAVYRTKLSKTALAGSKSLSLVHAVDWQVGEDILITTTSYDSKQTETRRITQISPDHRSL
ILNDTLSYTHIGERYQVPGTGQNYTLAADVGLLSRNIKIVGEDYPEWYEESFGARVLISS
FTSSRLTYKGNAR-ISNVEFYHTGQEGYRDHTDPRYSVSFLNLGQVGEYGSSYIRGCAFH
NGFSPAIGVFGTDGVDIDNNIIYFTVGQGIT-IWGN-DNRVRENLVALSLWPGTYQDRED
TSSTEWHAAIEINLGTNTVLQNNIVAGFERIGYRIDGEPCPGQHNPVEEWQNNEAHGGLF
GVYMNQDGLPGCSLI-----QGFTIWKCWDYGIYFQ----------------TTESVQIY
NVTLVENGMGIFSIIYTPAATSHKISSKTVQVENSLLIGSSPKFNCSDILTNEDPNIRLT
ATHRSCRP----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------K-GL

PF01833 // ENSGT00780000121902_0_Domain_13 (2058, 2122)

PGTKIQITGSSLGFDVSKILVTIDGIPCNVTHVNDSLLQCTVG
KHAGGNFPVFLHHLTKGYAES

ENSGT00780000121902_0_Linker_13_15 (2122, 2136)

TAIFEYPLTIENIL

PF10162 // ENSGT00780000121902_0_Domain_15 (2136, 2438)

PR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------EGGSLIFDEADIELQAENILISDGGILQIGTERAPFQHKAIITLH
GHLRSPELPVYGAKTLAVREGILDLHGRPIPVIWTRLAETAEAGENTLVLQEAVMWNVGD
EIIIATTGNSQSQRENEKRIIASIYADGTVITLTSPLNYTHLAVSVTLPDGTLFEGRAEV
GVLTRNILVRGSNNIEWNDKIPPCPEGFDSGEFATQTCLQGKFGEEMGSDQFGGCIMFHA
PQPNRNLVTGRLEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNVIYDIRGGAFFIEDGIEHGNILQSNLAVFVRQSSSLLNDDITPAAFWVT
NPNNSIRHNSVAGGTHFGFWYRMNNHPDGPSHDPHICQKRVPLGEFYNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTIPTPAIFNALTTWNCRKGAEWVNGGALQFHNFVVVNSADVGIET
KRILAPYVGGWGESSGAVIQNAKIVGHLDDLGLGPSYCSSKGLLLPFNEGLTVSSVHFMN
FDRPHCAAIGVTSIVGVCTDGCGGWSSRFASIQYFHTPNKAGFRWEHEVVLMDTDGSLTG
KMISN--SHQNMMDV---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MGH-LW--LLGT---WGFWGL-------LLCA
TDPRA-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 168)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFRSISCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVDGVPI

ENSGT00780000121902_0_Linker_1_2 (168, 199)

TESNTCRGRVKSW
ECTFNA-------RSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PMITNITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNKI-SMFQTY-----------------------AE

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 418)

VTMISPS
RGSIRGGTVLT-ISGRFFDQTDFPVRVLIGGQD----CDILNVTENSICCKTPP-KP

ENSGT00780000121902_0_Linker_3_4 (418, 430)

E-V
LRTVYPGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 557)

GLKLEVWNNSRPARLEEILEYNEETPGYMGASWVDSASYLWPTEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTRHPKDKDKVRIAYHSSNANGYFSSPTQRSD
DIHLQKGKEYYLEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFIDVGLYQYKNVYTEQQTEDAVNEEQVIRFQSTMVQE
VQVITLENWETSSATNEVQKITVTSPCVEENSCSRYQYRLIYNMEKT--AKVLLPGDASD
FLLQSALNELWSIKPDTVQVVRT-QNAQSYVYMVTFISTRGDFDMLGYETFEGDNVTLNI
TEQIKGKPSLDTFTLNWDGVTSKPLTPWSSQAEFQAAVEEMVTAKCPPQIANFEEGFDVK
YFRDYETDFNLEHVNRGKKTAETDAYCGRYALKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIALKFQYKDR-SKVTRSNDIQFTYNFANGN-NWTYTCIDLLDLIQTK
YIGTNFSLQRIGLQKASETQSFYVDAVYVGQTSTVSAWDEMPKRRLPALANKGIFLKSFQ
VNHTKTNGSSMTNQYSITMTSYNCSYNIPMMAVSFGQRITNETENESIYRGNNWPGESKI
RIQRIQAASPPLRGSFDIQAYGHILKAGLPATVSATDLQFALQSVEEVGRVSVTREGNCA
GYSWNIKWRSACGKQNLLQINDSNIIGEKANM--TVMKIKEGGLFRQRILGDLLRIPSQQ
PQVEVYVNGIPAKCSGDCGFTWDPMAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1244)

PLVRAINPSQGSYEESTVLTISGSGFSPNS---
AISVSVGPMACSLLSVS-QENEIQCQILNGSAGHFPVAVSVAD

ENSGT00780000121902_0_Linker_5_6 (1244, 1264)

AGLARNVEG-EEFYFTY
QNR

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1334)

ISYIWPTSGSLAEGGTLLTVSGFGFNENSRVLVGNETCNVIEGDLNKITCRTPKRIE
GTVDISVITNRFQ

ENSGT00780000121902_0_Linker_6_7 (1334, 1348)

AKAKDTYSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1434)

PVITDFSPKVRTI----IIGEVNLTIKGYNFGN
ELTQKVEVYVGGKPCQIFQWNLTDI-RCLLPKL-------SPGKHDIYVEVRN

ENSGT00780000121902_0_Linker_7_8 (1434, 1453)

WGFAST-
RDKLNASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1511)

EVTAMFPQRGSLYGGTE-ITIMGLGFSTIPTENTVLLGPFPCDVISSS
ENAIKCILHS

ENSGT00780000121902_0_Linker_8_9 (1511, 1693)

TGNTFRITNTGEDSVHGLGYAWSPSVLNVSVGDTVTWHWQAHPFLQGIGY
RVFSVSSPGSVIYDGKGFTNGREKSVSGSFSYQFTSPGIRYYSSGYVDEAHSIFLQGVIN
VSPAETRHIPLHLFVGSTEATYDQGL--TGPVNLHLGSSVTGCLATEPLCGPNNTRVKNS
DGLVFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PTINNINPSSGTLNELVTITGRGFSNLTCANKV-TIGSYPCIVEESSD
NSIICRIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

VREIVTLMVYNLGMAINTLPNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPYAGSTA
GLTRVTIKGSGFAASSAGIEVFMGHFPCKVLSVNYTAIECETSPAPQQLVKVDLLVHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1878)

YLESITA

PF01833 // ENSGT00780000121902_0_Domain_11 (1878, 1951)

VVTRIFPNSIE-GPVKVLIEGEGFGTILEDIAVFIGDQQFGAI
DVNEKNITVLVSPLPAGLHSLSVVVGSKGL

ENSGT00780000121902_0_Linker_11_12 (1951, 1960)

ALGNLTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVTPASGSIAGGTTLVI
TGNGFYPGNTTVTVGDEPCEIISVNSSEVHCYTPAGMAGRASVKIFVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LENT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRELVPNT-GPPGTKIQITGSNFGTNLLDILVMIDTLPCNVTMVNDSVLQCDTE
DHAGGTFPVTMHHKTKGFAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQSIHPSQG-SFGGGQTMTVTGTGFNPQTS
TILVCGSECAVDRLKSDRTALLCKIPHNDG-RGPEQACEVSV---VNGKDLFQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TVLLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2300)

PLVTEICPRRGSTAGGTRLTITGSGFSENMQDVLITIAEAKCDVEYSNKTYILCM
TSAHTSSGWAPVRVNIRGI

ENSGT00780000121902_0_Linker_15_16 (2300, 2320)

GMARLDDSDFLYVDAWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2439)

SWGGKSPPEEGSLVVITKGQT
VLLDQNTPILKMLLIQGGTLIFDEADIELQAENILITDGGLLQIGTEASPFQHRAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVSVIWTRLARTAKAGERTLILQEGVTWKPGD
KIVIASTGHRHSQRENEKRTIASVSADGTEIMLTDPLNYTHLGIIVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCFQGKFGEEIGSDQFGGCIMFHA
PIPGANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFNSYVRGCAIHQTYNRAVTI
HNTHHLLVERNVIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMETGACTSTVPVPAIFNSLTTWNCEKGAEWVNGGALQFRNFVMVNNFEAGIET
KRILAPYVGGWGETNGAVIKNAKIIGHLDELGMGSAFCTRKGLILPFSEGLTVSSVQFMN
FDRPKCVALGVTSITGVCNERCGGWSAKFVDIQYFHTPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCTQEAEWSIGFPGAVCDTSVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDVDHITNISYTSTFYGFKEEDYVI
VSHNFTQNPDMFKVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRNDVQQSQPI
SGTLDPDAKDVVINFQAYCCILQDCFPVHPPSRKPVPRKRPATYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSRENN
YTIPHPGANVVIPEGTWVVADTDIPPMESLIIWGVLELEDK-HNTGAAESSYRKIVLNAT
YISLQGGRLIAGWEDNPFKGELQIVLRGNHSTPEWTLPEGPNQGSKVLGVFGELDLHGIP
RSVYKTKLSETAEAGSKVLSLKDAVDWQEGEEIVITTTSYDFHQTETRSIIKILHDQKIL
ILNDTLSYTHLVNRRNAFDCIPCYKLKSIFSFLTEN-NLPGEGLCKLSKSSIAPKKKKKC
CHSSLPTLPGNAR-ISNVEFYHGGQEGFRDSTDPRYAITFLNLGQIQERGSSYIRGCAFH
NGFSPAIGVFGTDGLDIEDNIIHFTVGEGIR-IWGD-ANRVRGNLVTLSIWPGTYQNRRD
LSSTLWHAAIEINRGTNTVLQNNIVAGFGRVGFRIDGEPCSSQSNPMEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAISSMIYMPASVSHKISSKTVQIKSSLIVGSSPGFNCSDVLTNDDPNIELS
AAHRSARPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGLMS
YNAISGLLDISG--STFVGFKNVCSGETNVVFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDISKVNPADCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRMPVTEKAPYKGIIRDSTCKYIPQWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVDHRKAVVVGIFFPTLQRLDVYVNNALVCPKNTVWNPQQKYCELN--R
HLYTEQFLPNLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTTAVIFVSFQLPAVTEDDF
YNSHNLVRNLALFLKIPSDKIRVSKLMRGESLR--KKRST-GLTVELEIGDPPPPFLSND
TAGGMQMQLS-ELQKI--AGSLGKAVISGKTSSILGFNISSMSITNPIPSPSDSAWTKVT
AQPVERFA--FPVHHVAFVSSLSVIAQPVPAQPGQPFSQQPSVKAVDSDGNCVSVGITSL
TLKAVLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGKNYKIEFILDDVVRV-
----ESGTLSLAAQSVSGGGGTSGGGNS--------------------GRASTVGTAAQI
MVPVISCLLGRLVLLEVFMATVLISNIDLGKR----------------------------
-------------

----------------------------MGH-LW--LLGT---LGLWGL-------LLSS
VDSHAGNQVGASKKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSVHGATRLTIKGEGFSQANQFNYGVDTAELGNS
VQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPIAENATCRGHVNSW
ACSFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PMIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPQSDDLYGLKLDHPNGDMGSMICKITGTYIG--HHNVSFILD-S
DYGRSLPQKMS-

ENSGT00780000121902_0_Linker_2_3 (313, 355)

YFVSSLNKI-SMFQTF-----------------------AEV

PF01833 // ENSGT00780000121902_0_Domain_3 (355, 426)

AMISPS
KGSIQGGVTLT-INGRFFDRTDVPVRVLVGGQP----CDILNVTENTICCKTPP-RPD-V
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 452)

PGGRGLKLEVWNSSRPAHLEEILGYG

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 575)

ENTPGYMGATWVDSASYTWPVDHDTFVAR
FSGFLVVPDSDVYRFHIKGDDRYAIYFSQTGPPE--DKVRIAHHTANANSYFSSPTQRSD
DIHLQKGKEYYIEILLQEYRLSAFVDVGLYQYRS

ENSGT00780000121902_0_Linker_4_5 (575, 1168)

MYSEQQTGDAINEEQIIKSQSTIIQE
VQVITLENWETTIATNEVQKITVTSPCVEADSCSHYRYRLIHNMEKT----VLLPADASE
VVLQSALNDLWSVKPDTVRVIRT-QTLWSYVYTVTFVSDRGDFDLLSCEVFEGNNITVDI
AEQTKGKPSLETFTLNWDGILSKPLTPWASGAEFQVALEEMVSAKCSPQIAHFEEGFDVK
YFRDYENDFDLENVNRGQKTAETDAYCGRYSLKNPSVLFDSADAKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-GKIARSTDTQFTYNFSSGK-SWTYTCLDLLDLIQSK
QTGTNFSLQRISLQKASESQSFYVDIVYIGQISTTATIDEMAKRRFPALANKGIFLKQFH
VNQSKRDESTMTIQYSVTMISYNCSYNIPMMAVSFGQIIANETENESVYRGDNWPGESKI
RIQRIQEASPPISGSFDIQAYGHVIK-GIPATVSAADLQFALQSLEEMGRVSVTREGTCA
GFSWGITWKSTCGKQNLLQIDDSNITGEKANM--TVTKVKEGGLFRHRILGDLLRTPHQQ
PQVEVYINGIPAKCSGDCSFTWDSTAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PRVLAISPSQGSYEEGTTLTIVGSGFSPSS---
AVLVSVGSTGCSLLSVD-E-NEIKCQIVNGSAGHLPVAVSVA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVDS-KGLHFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1337)

QISHIWPESGSLA-GGTLLTLSGFGFSENSEVLVGNETCSVMEGNLNRITCRTPKRIE
GIVDISVITNGFQATS

ENSGT00780000121902_0_Linker_6_7 (1337, 1348)

RNIFRYSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVIKDFSPKIRTI-----LGDVNLTIKGYNFGN
EATQTVVVYVGGKTCQVLHWNSTDI-ICLLPVL-------PPGKHSVHVEVRNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1454)

FASI-
SGKLNASVQYVLE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHMFPHRGSLYGGTE-ITIMGSGFSLIPAENTVLLGSFPCSVTSSS
ENVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNVFRVTNTGEDLVHGLGYAWSPSVLNVSVGDTVIWHWQAHPFLRGIGY
RVFSVPSPGSVSYDGKGFTNGRPKSSSGSFSYQFTSPGIHYYSSGHVDEACSISLQGVIN
VLPAETRHLPLHVFLGGAEATYAP----GGPENLHLGSSVAGCLATEPLCGLNDTRVKDS
NIFLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITISGSGFSNLTCANKV-TIGRYPCVVEASND
HSITCHIDPQNSMEVST

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

RELVTLVVSNLGTAINTLSSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDTVLPNTGSTT
GMTRVIIKGSGFAGSSAGVEVLMGHFLCKVLTVNYTTIECETSPAPQQLVRVHLLIHGEP
GLCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYLTGVFPDSVR-GPVEVLIEGEGFGTVLGEIAVFIGTQRVRAI
DVNESNIAVLMPPLAAGLHSLRVVVATKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PMVASVSPTSGSLGGGTTLVI
TGNGFHLDNTTVTVGEAPCQITFANSSEVHCTTPAGKAGKVNLQILVNEVPYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEHT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIAPNA-GAPGTEIEITGSNFGSDISEISVTISDTGCTVTVVNDSVLQCTAG
DHAGGTFPVVLHHKTKGSAVSTIVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIHSIHPQQG-SFGGGQILTVTGAGFNPQDS
AVLVCGSECATDRLRSDQRTLLCEIPPNDG-MGPEQGCEVSV---VNGRDSSLSTALFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITELSPRKGSTAGGTRLTVQGSGFSADPQDVHVTLAEAKCDVEFSNETHIICV
TNAHTPSGWAPVHVNIRNMGTAKLVNTN

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDTWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLAVVTKGQI
LLLDQSTPVLKILLIQGGTLIFDEADIELQAENILITDGGILQIGTEESPFQHKAVITLH
GHLRSPELPLYGTKTLAVREGTLDLHGLPVPVVWTRLAQTAKAGEWTLILQEAVTWKAGD
SIVIASTGHRHSQRENEKRTIASVSADGVTITLTQPLHYTHLGITVTLPDGTVFEARAEV
GILTRNIVIRGSEKVEWNDTIPACPNGFDTGEFATQTCLQGKFGEEIGSDQFGGCVMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQSFNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTVRHNAAAGGTHFGFWYRMNNHPDGPSYDPNICQKRIPLGEFFNNTVHSQGWFGLW
IFEEYFPMKSGLCTSTVPLPAVFNSLTAWNCQKGAEWVNGGALQFHNFVMVNNYEAGIEA
KRILAPYVGGWGETNGAVIKNAKIIGHLDELGIGSAFCTSKGLVLPFSEGLTVSSVQFTN
FDRPNCVALGVTSITGICLDKCGGWSAKFIDIQYFHTPNKAGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSQLLDPAHCTQELQWSIGFPGSVCDTSVSFHRLAFNRPSPASLLEKDVILS
DSFGTSIVPFQKKRLTHMSGWMALIPNASHINWYFKDVGHITNISYTSTFYGFKEEDYVI
VSHNFTQNPDMFSIIDTRNGSSNPLNWSTSKNGDWHLETNTSTLYYLVSGRNDLQQSQSI
SGPLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPRKRPATYNFWSNHSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGGHVVIPEGTWIVADVDLPPMERLIIWGVLELEDK-SSAGAAEPSPRRVVLNVT
YISVQGGRLIGGWEDNPFRGELQIVLRGNHSTPEWALPEGPNQGAKVLGVFGELDLHGLP
RLIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETAEAGSKVLSLMDAVDWQEGDEIVITTTSYDLHQTETRSIIRILHGHRIL
ILNDSLSYNHLAKRYSVPETGQSYILAADVGLLSRNIKIVGEDYPGWSRESFGAHILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGFRDGTDPRYAITFLNLGQVQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYVRGCAFH
HGFSPAIGVFDTDGVDIDDNVIHFTVGEGIR-IWGD-ANRVRRNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINKGTNTVLQNNVVAGFGRAGYRIDGEPCSSQPNPVENWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTERVHIY
NVTLVDNGMAIFSMIYMPAAVSHKISSKTV--KSTLIVGSSPEFNCSDVLSNDDPNIELT
DEHRAYSISVNFLFLLPPPPLALPAPPSFLVKGGRSGICWPTFASAHNMAPQKPHAGIMS
YNAIRGRLDVSG--STFVGFKNVCSGEINVIFMTNPLNEDLQHPIYVKNIQLVNTTEPSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDLDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDATCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAVVSNGYVDLIN--GPQDHGWCAGYTCQKRLSLFHSIVALNKSYEVYFSS
TSPQNLRLLLLNVDHNKAVLVGIFYSTLQRLDVYVNNSLVCPRNTVWNTQQKRCGLN--R
HLYAEQFLPKLNSTILGENYFDRTYQMLYLLVKGTTPVEIHTVSVIFVSFRLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRISKIIQGKSLR--RKRST-GHTIELEIGDPPMKLLSND
TTGR--TKLS-KLQEI--SGSLGQAVILGKISSILGFNISSMMITNPIPSPNDSGWTKVT
AQPVARSA--YPVHRVALVSSLSVVTQPVAAQPGQPFSQQPSVKAVDPDGNCVSVGITSL
TLNAVLKDSSNNQVSGLSGNATIPFSSCWANYTDL---TPLGTGKNYKLEFLLDTVALA-
----ESRPFSLLAHS-----------SS---------S---GSSSGSHSKASTVGSSAQI
WVVLISCLMGRMLLLEILMAAAFTPNIGVGKYHSF---CT--------------------
-------------

----------------------------MGH-LW--RWRF---WGLWAL-------LLCA
AELRT-----DGSKIT

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PKVSGIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNDKLGNS
VQLVSTFRSISCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPIT

ENSGT00780000121902_0_Linker_1_2 (169, 199)

ENNTCKGHINSW
ACSFST-------KIFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRNITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHSNGDVGSMICKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 424)

EVTTISPS
QGSIAGGTRLT-ISGRFFDQTDFPTRVLVGGQP----CDILNVTENSICCKTPP-RPH-S
LRT

ENSGT00780000121902_0_Linker_3_4 (424, 429)

VYPGG

PF07691 // ENSGT00780000121902_0_Domain_4 (429, 558)

RGLKLEVWNNSQPVHLEEILEFNENTPGYMGASWVDSASYIWPMEQDMFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPED--KVRIAYHSANANNYFSSHTQRSD
EIHLQRGKEYYMEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVEVGLYQYRNVYSEQQTGDAVNEEQVIKSQSTIIQE
VQVCY--DYESTLLKVNIQRIKLFLKCDSQNIISLKIFHTFFL----LPTKVLLPADASD
FILQSALNDLWSIKPDTVRVTRI-QNPHGYTYTITFMSTRGDFDLFDYEVFEGNNVTLDI
TEQTKGKPSLETFTLSWDGIDSKPLSPLSSEAEFQAAVEEMVSAKCPPQIANFEEGFIVK
YFRDYETDFKLEHINRGQKTAETDAYCGRHSLKNPAVLFDSADVKPNKLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKTTRSTDVQFPFTFAYGN-NWTYTCIDLLDLIQTK
YAGTNFSLQRISLWKTSESQSFYVDTVYIGQQSTISTLYEMPKRRLPALASRGIFLKHFQ
VNQTKVNGSVLTNQYSVTMTAYNCSYNIPMMTVSFGQIITNKTEDESVYRGNNWPGESQI
RIQRMQAASSPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQNLQEVGQVSVTREGTCA
GYSWNVKWKSMCGKQSLLQVNDSNVIGQNANI--TVTKVKEGGLFRQRILGDLLRIPSQQ
PQVEVYVNGIPAKCSGDCGFTWDPMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEESTILTISGSGFSPSS---
AVSVSVGPVGCSLLSVDAQDNKIKCQILNGSAGHFPVVVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVEG-EVFYFTY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1339)

QISRIWPASGSLA-GGTLLTLSGFGFNENSEVFVGNESCNVLEGNLNMITCRTPKRIE
GTVDISVITNGFQAIAND

ENSGT00780000121902_0_Linker_6_7 (1339, 1348)

AFSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVITDFNPKIRTVL---VIGEVNLTLKGYNFGN
ELTQ-IKVYVGGKTCHILHWNFTDI-RCHLPKL-------LPGKHGIFVEVKNWGF

ENSGT00780000121902_0_Linker_7_8 (1437, 1453)

AST-
RDKLNTSIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTNIFPQRGSLYGGTE-VTIVGFGFSMIPTENTVLFGSFPCNVTSSS
ESVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNVFRVTNNGKDSVYGLGYAWSPSVLNVSVGDTVTWHWQAHPFLGGIGY
RVFSVSSPGSVIYDGKGFTSGRQKSASGSFSYQFTSPGIHYYSSGYIDDAHSFFLQGVIN
VSPAETKHLPLYLFVGRTEATYAG----GGPENLHLGSPAAGCLATEPLCGLNNTRVKNS
DRFLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNISPSTGTVNEMITITGRGFSNITCANKV-TIGNYPCVVEESSE
NCIMCYIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLTVYNLGVAINTLANEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNINTVLPNAGSTT
GMTRVTIKGSGFAASSASVEVLMGHLPCKVLSVNYTAIECETFPAPQQLVGVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDSLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1953)

PFITRISPNFIK-GSVKVFIEGGGFGTILEDIAVFSSNQEFRAI
DVNENNITVLVTPLPAGLHSLSVVVGSKGLAL

ENSGT00780000121902_0_Linker_11_12 (1953, 1960)

GNLTLSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVATLSPASGSIAGGTTLVI
TGNGFCPGNTVVIVGDNPCDIISVNSSEVYCYTPSGKPGMVNVEICVNGVAYPSLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRRIVPSR-GLPGTEIQIFGSNFGIDILEISVMINNVQCNITMVNDSVLQCVVG
DQAGGTFPVTMQHMTKGSAMSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

SIQNIHPRQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPPNNG-KLSKNQCEYSR---LNEGDXSRSTSPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PFITEVAPKRGSTAGGTRLTVMGSGFSENTQDIHITIADAKCDVEYSNKTHIICM
TNAHTSSGWAPVHVSIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2320)

GTGMAKLVNADFLYVNVWSSSF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2438)

SWGGKSPPEEGSLVVITNGQT
ILLDQNTPILKMLLIQGGILIFDEADIELQAENILITDGGILQVGTEAEPFQHKAVITLH
GHLRSPELPIYGAKTLAVREGILDLHGLPVPVIWTRLAHTAKAGDRILILQEAVTWKAGD
DIVIASTGHRHSQRENEKRTIASVSADGINITLTKPLNFTHLGITVTLPDGTVFDARAEV
GILTRNILIRGSDNMEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQYKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLSDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRIPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLDELGMGSAFCTMKGLLLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNESCGGWSAKFIGIKYFHTTNKAGFRWEHEVVLIDVDGSLTG
HRGHTVIPHSSLLDPSHCTQEAEWSVGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGKSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDIDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDVFNIIDKRNGSSNPLSWNTSKNGDWHLEANSSTLYYLVSGRNDLHQSQPV
SGTLDPDVKDVTINFQAYCCVLQDCFPVHPTAKKPIPRKRPATYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSQENN
YTVPHPGANVVIPEGTWIVADTDIPPMEKLTIWGVLELEDK-YNVGAAESSYRKVVLSAT
YISLQGGRLIGGWEDNPFKGDLQIVLRGNHSTPDWTLPEGPNQGSKVIGVFGELDLHGIP
HSIYKTKLSETAEAGSNVLSLMDAVDWQEGEEIVITTTSYDYHQTETRSIIKILHGRKIL
ILNDTLSYTHLGKRYHVPSTGQSYTLAADVGLLSRNIKIVGEDYPGWFKESFGARVLVSS
FTENMMAFKGNAR-ISNVEFYHSGQEGYRDSTDPRYAVTFLNLGQIQEHDSSYIRGCAFH
NGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGD-GNRVRGNLVALSVWPGTYQNRKD
LSLTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSTQSNPSEKWTDNEAHGGLH
GVYMNQDGLPGCSLI-----QGFTIWKCWDYGIYFQ----------------TTESVSIY
NVTLVDNGMAIFSMIYTPAAVSHKISSKIVQVESSLIVGSSPELNCSDVLTNDDPNIELT
VAHRSSRPP--------------------S--GGRSGICWPTFASAHNMSPRKPHAGIMS
YNAITGCLDVAS--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGSSGSVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFPNGSRIPAFEKAPYKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAVVSGGYVDLINDLGPQDHGWCAGYTCQRRLSLFHSVVALNKSYEIYFTG
TSPQNLRLMLLNVDHKKAVRVGIFFSTLQRLDVYVNNSLVCPKIQYGTLHQKACQIYNLN
HFYKEKYLPNLNSAVLGENYFDRAYQMLYLLVKGTIPVEIHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSKITRGKSLR--KKRSM-GLTIELEIGDPPTQFLSND
TAGQ--MQFY-ELQEI--AGCLGQGVILGKISSILGLNISAMSITNPIPSLSDSDWIKVT
VQPVERSA--FPVHHVAVVSSLSVITQPVATELGQPFSQQPSVKALDSDGNCVSVGITSL
TLKAVLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGKNYKIEFILGSVVRV-
----ESKTFSVPVQSASSSSGGSGGGS-----------------SSSNSKASAMGTAAQM
KTIVISCLIGRMLLLEIFTAAVLILNVTKGGY----------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQISCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 428)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDTLNVTEKSICCKTPP-KPH-I
IKAVYPG

ENSGT00780000121902_0_Linker_3_4 (428, 452)

GRGLKLEVWNNSRPIHLEEILEYD

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYIWPMEQDTFVAR
FTGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIVSKPLTPWSSEAEFQGAVEEMVSSKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRNTDIQFTYDFAHGN-NWTYTCIDILDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVVYIGQTATISTLDEMPKRRLPALANKGIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEGLGRVSVTCEGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTVLTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSLA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTAGDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1439)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIHVEVRNWGFASI-
RYDNEHKLDGVVEHMGLA----LTFRGCS-LYLS---TSSFAKYCLFFLGSIPCNVTSSS
ENVIKCILHSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITIIGHGFSNLTCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVNCRTPAGTTGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNLGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHISIAEAKCDVEYSNKTHIICV
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
VLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIAAVTADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSNVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIIKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIIGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-INNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IYIHRPDISKVNPSDCIDMVCDAKRKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKVMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGSIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSG----------------------SSSSSSTSTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVSTLKITLSKYSPL---IQYFSTY---------------
-------------

------------------------------------------------------------
-----------------------------------------FAQANEFNYGADNTELGNN
VQLVSSFRSISCDVEKDSSHSTQITCYTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXA-------KRFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDXXXXXXXXXXXX-XXX
XXXXVYVGGMPCELLIPQSDDLYGLKLDHSSGDTGSMICKTTGSYIGECHHNVSFILD-S
DYGRSYPHKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 450)

AEVSMISPS
QGSTQGGTILT-IHGRFFDQTDFPVRVLVGGQA----CDILKVTENSICCKTPP-KPD-I
LRSVYPGGRGLKLEVWNNTRPAHLEDILEYNAKMPGYMGISWVDSASYIWPLEEDTFVAR
LSGFLVAPDSDIYRFYIKGDDHYAIYFSKTGLPE--DKXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XLLTADASD
FKLQSALNDLWSIKPDTVQVIRF-RNSQSYVYMVTFISTRXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQAAVEEMVTAKCPPQIAKSEEGFVVK
YFRDFETDFNLEQINRGQRTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGSLENYLGLKFHYQDKSR-ITRNSDVQFIYNFASGD-NWTYACIDLLDLIQTK
YAGTNFSLQRITLQKKIQSQSFYVDIVYIGQTPTLSTWDDVPNRRLPALANRGIFLKNFQ
VNQTKMKGLSVTNQYFVTMTSYHCSYNIPLMAVSFGQVITNETENESVYRGNYWPGESKI
RIQRIQAASPPLSGSFDIHANGHILK-DLPAAVPAADLQFALQSLEGVGQVSVTREGTCA
GYSWNIKWRSSCGKQSLLQINDSNIIGEKVHV--TVTEIKEGGLFRKTILGDLLRTPNKQ
PQVEVYVNGIPAKCSGHCGFTWDPTIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1258)

PLISSTSPSQGSYEENTTLAILGSGFSPSS---
SVSVSVGPVGCHLISVD--EHELKCQILSGSAGRFPVVVSVADVGLAQNVEE-EVFY

ENSGT00780000121902_0_Linker_5_6 (1258, 1262)

FTY
Q

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

SQISHIWPASGSLA-GGTVLTLSGFGFNENSKVLVGNKTCHVIEGALNKITCRTPKRIE
GTVNISVITNGFKTTTKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1444)

PVITYFSPKVRT-----ILGEGHLTIKGYNIGN
ELTQNVEVHVGRKPCQILHWNFTDI-RCLLPTL-------SAGKHDISVEVINWGFAST-
RDK

ENSGT00780000121902_0_Linker_7_8 (1444, 1452)

LNTSIQYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVRDMFPQRGSLFGGID-LTIMGLGFSPEPTENTVLLGSFPCNVTSSS
ENVIKCTLHSTKNLFRITNSGEDSVHGLGSAWSPPVLNIFVGDTVMWHWQTHPFIKGIGY
RVFSVSTPGSVTYDGQGFTSGRERSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGIHYYSSGYVDEAHSMFLQGVIN
VLPAETRYIPLHLSVGSTEATYAL----GGYVNLHLGRSVTDCLATEPLCDLNNTEAKTS
DRMFFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1781)

PSISNISPSSGTLNDLITITGHGFSNLTCANK--TIGGYPCVE-ESHD
DSIICHVDPQNSMDVGIREIVTLTVSNLGNAINTLPNEFD

ENSGT00780000121902_0_Linker_9_10 (1781, 1787)

RRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDIVLPNAGSTT
GMTKVTIKGSGFAASSKDVNILMGHFPCYILSMNYTVIECETSPAPQQLVEVNLLIHGVP
AQCKGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESII

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

AFITRVSPNSVI-GSGNILIEGEGFGTILEDIAVSIGSQPSRAI
DVNENNITVHVTSLPAGLHSLRVVVRTKGLAVGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VNS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PTVASLTPTSGSIGGGNTLVI
TGNGFDSDTTTVTIGNEPCQIITVKSTKVQCYTPAGRAGRVSVKILVNTVAYPPLPFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEET

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLKGIVPRT-GPPGTEIQITC-YFGIAIS-ESVMINNAPCNVTMVNESVLQCIAG
DHAGGTFPVVMHHKAKGSAVSTIVYEYPLAIQHIHPSQXXXXXXXXXXXXXXXXXX--XX
XXXXXXXXXXXXXKLSGYPTFLCTIP-SNG-RGPEQVCDVSV---VNGKDRSQSTTSFTX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXENLQDVFITIAEAKCDVEFSNKTYIICM
TNAHIHSGSSPVHVNIASIGVAKSDNADFLYVDVWSSNSSWGGKSLPEEGSLVVITKGQT
VLLDQSTPVLKMLLIQGGTLIFDEVDIELHAENILITDGGVLQIGTEESPFQHKAIITLH
GHLRSPELPVYGAKTLAVREGILDLHGQPVPVVWTRLSQTAKAGERILILQEAVTWKPGD
TIVIASTGHRHSQQENEKSTIASVSADGTNITLTNPLNYTHLGITITLPDGTLFEARAEV
GILTRNILIRGSDQMEWSNKIPACPDGFDTGEFATQTCFQGKFGEEIGSDQFGGCIMFHA
PVPSANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCSIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDPNICQKRVPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSTVPVPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILTPYVGGWGEDNGAMIKNAKIVGHLDELEMGSTFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCAALGVTSITGVCNERCGGWSAKFADIQYFHTPNKAGFRWEHEVVLIDVDSTLTG
KKGYTVIPYSSLLDPSHCTQEAEWSVGFPGSVCDTSVSFHRLAFNKPSPVALLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNARHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLSWNTSKNGDWHLEANTSTLYYLVSGRNDLPQSQPI
SGALDPDVKDVIINFQAYCCVLQNCFPIHSSSRQPXXXXXXXXXXXXXXXXX--------
-XXXXXXXXXXXXXXTWIA---DTDPPMRLIILGVLELEDKHN-MGAAEYSYRTIVLNAT
YILLQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXGSKLSLVDSVDWQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXERYQVPGTGQSYRLAADVGILSRNIKIIGEDYPGWFKESFGARVLVSS
FTENM-TFKGNAK-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQSQEHGSSYIRGCAFH
SGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGD-ANRVRRNLVTFSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-----XXXXXXXXXDYGIYFQ----------------TTESVHIY
NVTLVDNGMAISSMIYMPTAVSHKISNKMVEIKNSLIVGSSPEFNCSDVLTNDDPNIELS
AAHRSSRPP--------------------SG--GRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXETRKTSPVAIVSSGYVDLNX--XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXAVLVGIFFPTLQRLDVYVNNVLVCPKNTIWNSQQKHCKLK--R
HLYPEQFLLNLNSTVPGENYFDRTYQMLYLLVQGTAPVEIHTTAVIFLSFHLPAITEDDF
YSSHTLVRNLALFLNIPSDKIRISKIMQRKNLQ--RKRSL-GLLVELEIGDPPPQFRSND
TAG--QMKIS-ELQEI--AGSLGQAVILGKSSSIFGFNISSMSITNPIPHPSDSGWIKVT
SQPVERSA--FPVHHVALVSSLSVITQPVTAQLGQPFSHQPSVKAIDSDGNCVSVGVTSL
TLKAILKDPSNNQISGLGGNTTIPFSSCWANYTDL---TLLKT-----------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 292)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--KC

ENSGT00780000121902_0_Linker_2_3 (292, 353)

WSSFFI---
---MSFPQKMA-YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGET----CDALNVTENSICCKTPP-KPH-I
FKAVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 452)

GLKLEVWNNSRPIHLEEILEYD

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGASWVDSASYIWPIEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKITSPCVEANSCSSYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFVSTRGDFDLLDYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYPDN-SKITRSTDIQFTYDFAHGN-NWTYTCIDLLDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVLYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEGLGRVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRIPSQQ
PQVEVYVNGIPAKCSGDCGFTWNSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGD-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNATCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGH
ELTQNMTVYVGGKTCQILHWNVTDI-RCLLPKL-------SPGKQDIYVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNITSSS
ENVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNLFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWQWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PSISNITPSTGTVNELITIIGHGFSNLPCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGVRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVNVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGDQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVDCRTPAGTNGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVRGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHITIAGAKCDAEYSNKTHIICM
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLARTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDTRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIVGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQRAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGERYMLAADVGILSRNIKIVGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3634)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------VIMIKDVL
F----------IIMFYFS------------------------------------------
------KSE--------------------KFETLISGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLIDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNMSYEVYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQFPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQEI--AGSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPIERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSGSS----------------------SSSSTSTVGTYAQI
MTVVISCLIGRMWLLEIFMAAVSTLKITLSKYSPL---IQYFSTY---------------
-------------

----------------------------MRH-LW--LLGI---WGLWGL-------LLCA
ANPRT-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGADNAELGNS
VQLVSSFQSIACDVEKDASHSTHITCYTRAMPEGSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIERSSNG-KNV
RILRVYNGGMPCELLIPQSDNLYGLKLDHADGDMGSMICKTTGTFIG--HHNASFILD-S
DYGRSLPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLSKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTTIFPS
RGSIQGGTTLT-ISGRFFDQTDFPVRVLVGGET----CHTLNVTENSICCKTPP-KPH-I
LKTVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 443)

GLKLEVWNNSRPV

PF07691 // ENSGT00780000121902_0_Domain_4 (443, 558)

HLEEILEYNEKTPGYMGASWVDSASYIWPMEQDRFVAR
FSGFLVAPDSDVYRFYIRGDDRYAIYFSQTGLPE--DKVRIAYNSANANSYFSSPAQRSD
DIYLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTKAINEVQKIKVTSPCVEANSCSLYQYQLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVIRT-RNAQSYIYTITFISTRGDFDLLGYEVFEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASRPLTPWSSEAEFQRAVEEMVSTKCPPQITNFEEGLVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDS-SKIIRSTDVQFTYNFAYGN-NWTYTCIDLLDLIRTK
YTGTNISLQRISLQKASESQSFYVDVVYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNWTKINGPTMTHQYFVTMTSYNCSYNIPMMAVSFGQIITYETENEIVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAGVSAADLQFALQSLQGMGRVSVTREGTCA
GYTWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSAITPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLGTSPSQGSYDEGTILTIVGSGFSPGS---
ALTVSVGPVGCYLLSVD-E-KEIKCQILNGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHICPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YDCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTV-----LGEVNLTINGYNFGN
ELTQN-VVYVGGKICQILHWNFTDI-RCLLPKL-------PPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPAENAVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGFVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
DRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSSGTVNELITIIGHGFSNLPCANKV-TIGSYPCVTEESSD
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNVGSTT
GMTRVTIKGSGFAVSSAGVEVLMGHFPCKVLSVNYTAIECETSPAGQQLVDVYLLIHGVP
ALCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PYITGISPNSII-ESVKVIIEGEGFGTVLDDIAVFIGNQQFRAI
DVNENNITALVTSLPVGRHSLSVVVGSKGLALG

ENSGT00780000121902_0_Linker_11_12 (1954, 1962)

NLSVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASVSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVYCHTPPRTAGMVGVKIFVNTISYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPSR-GPPGTEIEITGSNFGIEILDISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAISTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQSINPSQG-SFGGGQTMTVTGTGFNPQNS
IILICGTECAVDRLRSDYTTLLCEIPSNNG-RGAEQTCEVSV---VNGKDLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
ALFLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2310)

PLITAVSPKRGSTAGGTRLTVMGSGFSENIEDVHITIAEAKCAIECSNKTHIICM
TDAYPLSGWAPVHVHIRGVGMAKLDNGDF

ENSGT00780000121902_0_Linker_15_16 (2310, 2321)

LYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTCLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGITITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLHFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTVRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEDYFPMQTGSCTSTVPMPARFNSFTAWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLDELGMGSAFCTRKGLVLPFSEGLTVSSVHFMN
FDHPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEPEWSIGFPGSVCDASVSFHRLAFNKPSPASLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKDEDYVI
ISHNFTQNPDMFNIIDIRNGSSNPLNWDTSKNGDWHLEANTSTLYYLVSGRNDLQQSQPI
SANLDPDVKDVVINFQAYCCILQECFTVYPPSRKPMPKRRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGIWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTRDWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETADAGSKILSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDRKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVGEDYPGWYQDSFGAHVLVGS
FTENMMTFKGNAR-ISNVEFYHCGQEGFRGSTDPRYAVTFLNLGQIQEHGSSYIQGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
FSSTLWHAAIEINGGTNTVLQNNVVAGFARAGYRIDGEPCPSQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTENVHIY
NVTLVDNGMAIFPMIYLPAAISHKISNKKVQIKSSLIVGSSPGFNCSDILTNDDPNVELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAINGLLDVSG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGFVIPQAEYEWDGKSQLGIG
DYRIPKVMLTFLNGSKIPVTEKAPHKGIIRDSTCTYIPQWQSYQCFGMEYALMVIESLDP
DTETRRISPVAIVGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKHCELN--T
LLYKDQFLPNLASTVLGENYFDRTYQLLYLLVKGAIPVEIHTATVIFVSFQLPAVTEDDF
YTSQNLVRNLAFFLKIPSDKIRISKMIREKSLR--RKRSI-GFIIEIEIGDPPIQFLNNG
TTGQ--MQLS-ELQEI--AGSLGQAVILGKISSILGFNISSMSITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLSVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVSGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVRV-
----ESRTFSLQAESVSSSSG---SSSS---------SSSSGGGSSSNSKASTVGTSAQI
MTAVISCLIGRMWLLEIFMAAVSTVNITLRSY----------------------------
-------------

----------------------------MGH-LW--LSET---WFLFGL-------LWCA
ADSHK-----GSSETI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSINGATRLTIKGEGFSQASQFTYGADNTELGNH
VQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDTYSVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVAENNTCKGVASSW
ACSFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-RNV
RILRIYVGGMPCELLIPHSDDLYGLKLDRANGDTGSVTCKTTGTYIG--HHNVSFILD-S
DYGRSFPEKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 438)

PEVVMVSPS
KGSTEGGTILT-IHGQFFDQTDLPVRVLVGGQA----CAILNVTENTIYCKTPP-KPH-V
LKATYPGGRGLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTE--DKVRIAYYSGNANTYFSNSTQRSDEIHLQKGKEYYIEILLQEYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVIPEVQIITLENWETADVTNEVQQVTVTSPCVGANSCSLFQYRFIYNMEKT----VWLPADASDFMLKSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSITEQTKGKPNLETFTLNWDGIASKPLTPESSEAEFQVAVEEMVSARCPPEIAHLEEGFLVKYFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYNQLCLAYKGSLANFIGLKFKYQDS-GKIIRSADVQFEYNFASGN-KWAYTCIDLLDFLQTKYAGTSFSLQRISLQKSSEFQSIYVDAVYIGQTPTVSVLDEMPKRRPPALANKGIFLKNFHVNRTKLNGSAMTIQYSVTITSYNCSHNLPMMAVSFGQIITNETKNELVYRGNNWPGESKIRIQRIQEASPPISGSFDVQAYGHTLK-GIPAAVSAADLQFALQSLEEIAQVSVNREGTCAGYSWSIKWTSPCGKQPLLQINDSNIIGEKANV--TVTTIKEGGLFRQRIPGDMLRTLNQQPQVEVYVNGIPAKCSGDCGFTWDAMITPLILTTTPSEGSYAESTILTIAGSGFSPTS---AVSVSVGSTRCSLLSVE-E-NEIKCQILNGSAGHVPVAVSIADVGLAQNLEG-EGSHFVYRSQISHVWPDSGSLA-GGTLLTISGFGFGENSTVLVGNETCNVIKGDLNRITCRTSKRIEGTVDISVITNGIQVIAKDSFSYSCLQTPVVTDFSPKERTV-----LGKVNLTIKGYNFGNELAQNT-VYVGRKLCQVLHSNFTDI-TCLLPTL-------PPGKHDIYVKVRNWGLAST-RNKLNASILYILEVIHMFPQRGSLYGGTE-ITIMGFGFSTIPTENSVLLGSFPCEITSSSETVIKCTLHSTGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGYRIFSVSSPGSVTYDGKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVIKVFPAETRHIPLHLFVGNIEATYVP----AGPEHLQLASTAAGCLATEPLCGLNDTRVQHSSKLFFELSNCISPSIINITPSTGTANELITINGHGFSSLPCANKV-TIGSYPCVVEESSENSIICHIDPQNSMNVGIREIVTLIVYNLGTAINTLTNAFDRRFVLLPHIDMVMPKAGSTTGMTRVTIQGSGFMASPAGVEVFMGDFPCKVLSVTYTAIECETSPAPRQLVLVDILIHGVPAQCQSNCSFSYLENIAPYVTGVFPNSIQ-GYGNVLIKGEGFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNLTIRSPALASVSPTSGSIAGGTTLIITGNGFSPGNTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAIIYPPLSFTYAMEDTPFLKRIIPNR-GLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVMMLHKTKGSAVSSVVFEYPLSIQNIYPRQG-SFGGGQTLTVTGMGFDPWNSTILVCDSECADDKLISNSTTLVCEIPPNNG-KGPDQVCGVSV---VNGKDSSQSMKLFTYTLSLTPLITEVSPRRGSTAGGTRLTVTGSGFSENAQDVQVSIANSKCDIQYSNKTHIICVTSAHAPSGWAPVHVNIKNIGLAKLENADFLYADVWSANSSWGGNPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGGTLIFDEADLELQAENILITDGGVLQIGTEASPFQHQAVITLHGHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTITVREAVTWKAGDSIVIASTGHRHSQAENEKRTIASVSADGMHITLTRPLNYTHLGITTTLPDGTVFEARAEVGILTRNILIRGSDNVEWNDKIPPCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHAPLLGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLWIFEEYFPMQTGSCTSTVPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNHEAGIEAKRILAPYVGGWGESSGAVIKNAKIVGHLDELGMGPIFCTSKGLVLPFSQGLTVSSVHFMNFDRHACVALGVTSITGVCNDRCGGWSAKFVGIQYFHAPNKAGFRWEHEAVLIDVDGSLTGHRGHTVVPHSSLLDPSHCSQEPAWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLSDSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVIISHNFTQNPDMFNVVDMRNGSSNPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPISGTLDPDGKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPATYTLWSNESFWQSSPENNYTVPRPGANVVIPEGTWIVADVDIPPMERLIIWGVLEMEDK-SEIGVAGPTYRRVVLNATYISIQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLPRSVYKTKLLETAEAGSKILSLVDAVDWQKGEDVVITTTSYDLRQTEIRKIVKILHGHKILILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDNYSVLSKDSFGARILVGSFTGNMMTFKGNAR-ISNVEFYHSGQEGYRDSTDPRYAVTFLNLGQIQDRGLSYVRGCAFHHVFSPAIGVFGTDGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKDLSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANSMENWFNNEAHGGLYGIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESMHIYNVTLVNNGMSIFSMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELTSAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLDTVN--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLIDTTEQSKVFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNRQLGIGDYRIPKAMLTFLNGSRIPVAEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDSDTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKTYEVYFTGTSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKHCELE--RHLNTEQFLPNVGSTVSGENYFDRTYQMLYLLLKGTTPVEVHTATVIFVSFQLPVMTADEFFSSHGLVRNLALFLKIPSDKIRVSRIIG-ASLR--KKRST-GHIMEVEIGAAPIQFLNNSTTGQ--MQLS-ELQEI--TSSLGQAVVLGKINTILGFNISSMSITSPIPQPTDSGWIKVTAQPVERSA--FPVHHLALVSSLSVVVQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSLTLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDL---TPHRTGKNYKIEFVLDNTVRV-----ESRPFSLSAQNVPGGSGSST-STG--------------SSSSGHSKASSVGTSVQTLSVVTACLVGRLLLLEIFVAAVFILNTTIGKR---------------------------------

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVAR
ISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTE--DKVRIAYYSGNANTYFSNSTQRSD
EIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVIPE
VQIITLENWETADVTNEVQQVTVTSPCVGANSCSLFQYRFIYNMEKT----VWLPADASD
FMLKSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSI
TEQTKGKPNLETFTLNWDGIASKPLTPESSEAEFQVAVEEMVSARCPPEIAHLEEGFLVK
YFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYN
QLCLAYKGSLANFIGLKFKYQDS-GKIIRSADVQFEYNFASGN-KWAYTCIDLLDFLQTK
YAGTSFSLQRISLQKSSEFQSIYVDAVYIGQTPTVSVLDEMPKRRPPALANKGIFLKNFH
VNRTKLNGSAMTIQYSVTITSYNCSHNLPMMAVSFGQIITNETKNELVYRGNNWPGESKI
RIQRIQEASPPISGSFDVQAYGHTLK-GIPAAVSAADLQFALQSLEEIAQVSVNREGTCA
GYSWSIKWTSPCGKQPLLQINDSNIIGEKANV--TVTTIKEGGLFRQRIPGDMLRTLNQQ
PQVEVYVNGIPAKCSGDCGFTWDAMIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1248)

PLILTTTPSEGSYAESTILTIAGSGFSPTS---
AVSVSVGSTRCSLLSVE-E-NEIKCQILNGSAGHVPVAVSIADVGLA

ENSGT00780000121902_0_Linker_5_6 (1248, 1263)

QNLEG-EGSHFVY
RS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1333)

QISHVWPDSGSLA-GGTLLTISGFGFGENSTVLVGNETCNVIKGDLNRITCRTSKRIE
GTVDISVITNGI

ENSGT00780000121902_0_Linker_6_7 (1333, 1348)

QVIAKDSFSYSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVVTDFSPKERTV-----LGKVNLTIKGYNFGN
ELAQNT-VYVGRKLCQVLHSNFTDI-TCLLPTL-------PPGKHDIYVKVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1457)

AST-
RNKLNASILYILEVIH

PF01833 // ENSGT00780000121902_0_Domain_8 (1457, 1510)

MFPQRGSLYGGTE-ITIMGFGFSTIPTENSVLLGSFPCEITSSS
ETVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGY
RIFSVSSPGSVTYDGKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVIK
VFPAETRHIPLHLFVGNIEATYVP----AGPEHLQLASTAAGCLATEPLCGLNDTRVQHS
SKLFFELSNCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PSIINITPSTGTANELITINGHGFSSLPCANKV-TIGSYPCVVEESSE
NSIICHIDPQNSMNVGIRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVTLIVYNLGTAINTLTNAFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PHIDMVMPKAGSTT
GMTRVTIQGSGFMASPAGVEVFMGDFPCKVLSVTYTAIECETSPAPRQLVLVDILIHGVP
AQCQSNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1955)

PYVTGVFPNSIQ-GYGNVLIKGEGFGTVLEEISIFIGSQQFRVI
DVNENNITVLMTPLEAGLHSLSVVVGSKGLALGN

ENSGT00780000121902_0_Linker_11_12 (1955, 1961)

LTIRSP

PF01833 // ENSGT00780000121902_0_Domain_12 (1961, 2039)

ALASVSPTSGSIAGGTTLII
TGNGFSPGNTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAIIYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKRIIPNR-GLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVG
EHAGGIFPVMMLHKTKGSAVSSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

SIQNIYPRQG-SFGGGQTLTVTGMGFDPWNS
TILVCDSECADDKLISNSTTLVCEIPPNNG-KGPDQVCGVSV---VNGKDSSQSMKLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2304)

PLITEVSPRRGSTAGGTRLTVTGSGFSENAQDVQVSIANSKCDIQYSNKTHIICV
TSAHAPSGWAPVHVNIKNIGLAK

ENSGT00780000121902_0_Linker_15_16 (2304, 2321)

LENADFLYADVWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGNPPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADLELQAENILITDGGVLQIGTEASPFQHQAVITLH
GHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTITVREAVTWKAGD
SIVIASTGHRHSQAENEKRTIASVSADGMHITLTRPLNYTHLGITTTLPDGTVFEARAEV
GILTRNILIRGSDNVEWNDKIPPCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHA
PLLGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNHEAGIEA
KRILAPYVGGWGESSGAVIKNAKIVGHLDELGMGPIFCTSKGLVLPFSQGLTVSSVHFMN
FDRHACVALGVTSITGVCNDRCGGWSAKFVGIQYFHAPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVVPHSSLLDPSHCSQEPAWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVVDMRNGSSNPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPI
SGTLDPDGKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPATYTLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3308)

WQSSPENN
YTVPRPGANVVIPEGTWIVADVDIPPMERLIIWGVLEMEDK-SEIGVAGPTYRRVVLNAT
YISIQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLP
RSVYKTK

ENSGT00780000121902_0_Linker_18_19 (3308, 3473)

LLETAEAGSKILSLVDAVDWQKGEDVVITTTSYDLRQTEIRKIVKILHGHKIL
ILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDNYSVLSKDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGYRDSTDPRYAVTFLNLGQIQDRGLS

PF13229 // ENSGT00780000121902_0_Domain_19 (3473, 3605)

YVRGCAFH
HVFSPAIGVFGTDGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANSMENWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESMHIY
NVTLVNNGMSIFSMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDTVN--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLIDTTEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNRQLGIG
DYRIPKAMLTFLNGSRIPVAEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDS
DTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKTYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKHCELE--R
HLNTEQFLPNVGSTVSGENYFDRTYQMLYLLLKGTTPVEVHTATVIFVSFQLPVMTADEF
FSSHGLVRNLALFLKIPSDKIRVSRIIG-ASLR--KKRST-GHIMEVEIGAAPIQFLNNS
TTGQ--MQLS-ELQEI--TSSLGQAVVLGKINTILGFNISSMSITSPIPQPTDSGWIKVT
AQPVERSA--FPVHHLALVSSLSVVVQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSL
TLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDL---TPHRTGKNYKIEFVLDNTVRV-
----ESRPFSLSAQNVPGGSGSST-STG--------------SSSSGHSKASSVGTSVQT
LSVVTACLVGRLLLLEIFVAAVFILNTTIGKR----------------------------
-------------

----------------------------MAH-LW--LLGT---WSIWGL-------LLGS
AAPRT-----DGSKVI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 175)

PKVTEIIPKYGSINGATRLTIKGEGFAQANEFNYGVDNAEMGNS
VQLVSSFRSISCDVEKDSSHSTQITCYTRAMPEDSYTVRVSVDGVPVTENNTCKGHINSH
ACSFNA-------KSFRTPTIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-RNV
RVLXXXXXXXXXXXXXXXXXXXYGLKLDNLSGDMGSMVCKTTGTYIGKCHHNVSFILD-S
DYGRXXXXXXXXXXXXXXXXXXXXXXXX-----------------------XXXXXXX--
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQA----CEILNVTEESIYCKTPP-KPD-H
LRTMYPGGRGLKLEVWNNSRPAHLEEILEYNEKTPGYTGAIWVDSASYIWPMEHDMFVAR
FSGFFVAPDSDIYRFYIKGDDRYAIYFSHTGVPE--DKVKIAYHSSNANNYFSSPTQSSD
DIHLQKGKEYYIEILLQEFRLSAFVDVGLYQSKNVYTEQQTEDAVNEEQVVKFQSTIVEE
VQVITLEKWETTDSTKEVQKITVTSPCLESHSCSLYQYRLIYKREKT----VLIPADASD
STLQSALNDLWSIKPDTVQVIRT-QNPQSYVYTVTFLSTRGDFDMLGYEVFEGNNVTLDI
TEQTKGKPSLDTFTLNWDGISSRPLTPWSSEAEFQEAIEEMVTTKCPPHISHFEEGFAVK
YFRDYEADFNLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XLCLAYKGFLENYIGLKFQYQDKKK-ITRSIDEQFAYNFAYGN-NWTYTCVDLMDLIQTK
YSGTNFSLQRINLQKTSESQSFYVDTVYIGQISTISTWDEMPKRRLPALADKGIFLKNFQ
VNQTKINGPTMASQYSITMTSYNCSYNIPMMAVAFAQAITKETENESVYRGNNWPGEAKI
RVQRAQAASPPLSGSFDIQAYGHVLK-GLPADVSAADLQFALQSLEEVGQVSVTREGTCA
AYSWNITWRSTCGRQNILQINDSNIIGENVNV--TVLKIKEGGLFRQRILGDLLHIPSQE
PQVEVYVNEIPAKCLGDCGFTWDPLVT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1258)

PLISSTSPSQGSYEENTVLTILGSGFSPSS---
SVSVSVGTNSCPLISVN--ENVIQCQIQTGSAGLFPVVVFIADVGIAQNIEG-EIFRFMY
QSNISHIWPASGSLA-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXX
XXXXXX-XXXXXXXXXXXXXXXXXX-XXXXXXX-------XXXXXXXXXXXXX-XXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSPSVLNVSVGDTVIWHWEAHPFLRGIGY
RVFSVSSPGSVVYDGKGFTNGREKSASGSFSYQFTSPGLHYYSSGYVDEMHSVFLQGVIM
VLPAQTRQVPLHVSVDSTEATFAQ----GKPMALHPESSAASCMAVEPQCDPGNARVQNS
SKLVFELSSCSS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1781)

PSINNITPTVGTLNELITISGHGFSNLTCANKV-TIGRYPCVVKESSA
DSIVCHIDPQNSMDVGIREIVSVTVYNLGTAISTPSNEFD

ENSGT00780000121902_0_Linker_9_10 (1781, 1787)

RRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDTVLPDAGSIT
GMTKVTIRGSGFAVSSEGIEVLMGYFPCQVLSVNYTTIECETSPAPQQLVKVTLLVHGVP
AECQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

ALITRITPDSIL-GPVNVLIEGEGFGTVLEDITVFIGNQPFGAV
EVNENNITVSVTPLPAGLHALRVVVGSTGLALGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAIASVTPASGSLGGGTILVI
TGNGFTPGNTTVTVGNDPCQMIYVNLSEIHCHSPAGAAGSASVKITANAVAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLREIVPNK-GPPGTEIQITGSNFGVDALDISVVIDGVPCTVMKLNDSVLHCLAG
DHPGGVFPVLMHHGKKGSAVSTVTYE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTIQNIQPSQG-SFGGGQTLTLTGSGFSPQNS
VVSVCGSACTVDRLNSDSTTLVCKIPPHHG-EGPAQACEVTV---ANGKDLSQSPALFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SASLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLISAVSPTRGTTAGGTRLTVEGTGFSENMQDVLVMIGKAKCDVEYSNKTCIICV
TSVHMSSGEVPVHVNIRSSGLARVEDAYFSYVDVWSSSLSWGGKSPPEEGSLAVITKGQT
IXXXXXXXXXXXXXXXXGTLIFDEADIELQAENILITDGGILQIGTEASPFQHQAIITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPVPVIWTRLAQTAKAGEKTLILQEAVTWKAGD
KIVIASTGHRHSQRENEKRTIAFVSADGINITLADPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSNNMEWDNKIPACPDEFDTGEFATQTCFQGKFGEEIGSDQFGGCIMLHA
PMPGANMVIGRIEYVEITHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSFDRNICQKRVPLGEFFNNTVHSQGWFGIW
IFEEYFPMLTGSCTSTVPIPAVFHSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPFVGGWGETSGAMIKNAKIVGHLDELEMGSTFCTMKGLILPFSEGLTVSSVRFMN
FDRPGCVALGVTSITGVCNERCGGWSAKFVNIQYFHAPNKAGFRWEHEVVLIDTDGSLTG
HKGHTVIPYSPLLDPSHCTQEAEWSIGFPGAVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMAGWMALIPNAKHINWYFKDVEHITNISYTSTFYGFKEEDYVI
ISHNFTQNPYMFNVIDMRNGSTNPLDWNTSKNGDWHLEANTSTLYYMVSGRNELPQSQPI
SGTLDPAVKDVVINFQAYCCILQDCFPVHPSARKPIPRTRPATYNLWSNDSFWQSSPENN
YTVPHLGN-VIIPEXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX
XXXXXGGRLIGGWEDNPFKGELHIVLRGNHSTPGWPLPEGPNQGSKVLGVFGELDLHGLP
RAIYKTKLSETAESGSKILSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
VLNETLSYTHLAERHRIPETGQSYTLAADVGLLSRNIKILGEDYPGWFKESFGARVLVSS
FTQNMMTFKXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNAERGSSYIRGCAFH
NGFSPAIGVFGTDGLDIDDNIIYFTVGEXXX-XXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX------XXXXXXXXXXXXXXXX----------------XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX--------------------XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXKVNPSDCVDMVCDAKRKSLLRDMDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPNVMLTSPNGSRIPITEKAPYKGIIRDSSCKYIPEWQSHRCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXAVMAGIFFPTLQRLDVYVNNALVCPKNTAWNSQQKYCELN--S
RLSADQVLPKLNSTILGENYFDRTYQMLYLLIKGTIPVEIHTTAVIFVSFQLPAVAEDDF
YNSHNLVRNLALFLKIPSDKIRISKILLGEHVR--SKRSI-GLTLELEIGDPPPQFLSND
TTG--QMHVS-ELQEI--AGSLGRAVILGKTMNILGFNVSSMSISNPIPNPQDSDWIKVT
AQPVKRSA--FPVHHVAWVSLLSVITQPVAAQPGQPLSQQPSVKAVDSEGNCVSVGITSL
NWKAVLIC-SNKKISGLSGNT-TPFISWWPNYTDL---TPLST-----------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MGH-LW--LWGT---CGLWGL-------LLSI
AEPRA-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKITEIIPKYGSINGATRLTIKGEGFAQANQFDYGVDNAELGNR
VQLISSFRSISCDVEKDSSHSTHITCYTRAMPEDSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHVSSR
ACIFSA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIRGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLISQSDNLYGLKLDHPNGDMGSMVCKMSGTYIG--HHNVSFILD-S
DYGRSLPEKTA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 432)

EITRISPS
QGSTQGGTLLT-ISGRFFDQTDFPVRVLVGGQA----CRILNVTENSICCKTPP-EPD-I
LRTIYPGGRGL

ENSGT00780000121902_0_Linker_3_4 (432, 452)

KLEVWNNSRPVRLEEILEYS

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

EKTPGYMGAIWVDSASYVWPMEQDTFVAR
FSGFLVAPESDVYRFYIKGDDRYAIYFSQTGLPED--KVRIAYHSSNANNYFSSPTQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVGVGLYQYKSVYTEQQTEDAVNEEQVIKSQSAVVQE
VQVITLENWETTHATNEVQKVMVTSPCVEANLCSLYQYRLIYNMEKT----VWLPADASE
FILQSALNDLWSIKPDTVQVIRT-QDPRSYVYLITFISTRGDFDLLSYEAFEGNNVTLAI
TEQTKGKPSLDTFTLSWDGITSRPLTLQSSEAEFQAAVEEMVSSKCPPQIATFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKQNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDP-SKIARSTDTQFPFKFAYGN-NWTYTCIDLLDLIQTK
YTGTSFSLQRISLQKASESQSFYVDIVYIGQTSTMTTLDEMSKRRLPALANKGIFLKDFQ
VNQTKSNGSSITNQYSVTMTSYNCSYNIPMMAVSFGQRITNETENESVYRGNNWPGESKI
RIQRIQAASPPLRGSFDIHAYGHVLT-GIPAAVSAADLQFALQSLEEVGQVSVTREGGCA
GYSWRVKWRSTCGKQPLLQINDSNIFGENANM--TVTKIKEGGLFRQHVPGDLLRTPSKQ
PQVEVYVNEIPAKCSGNCGFTWEPTTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PQIRAINPSQGSYEESTILTISGSGFSPSS---
SVSVSVGPAGCSLLSL--SENEIKCQILNGSAGRFPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGRARNVEE-KGFHFTY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1336)

QISHIWPASGSLA-GGTLLTVSGFGFHEYSKVLVGNETCNVIEGDLNKITCRTPKSIE
GTVDISVITSGVQAT

ENSGT00780000121902_0_Linker_6_7 (1336, 1348)

AKNAYSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1440)

PVITDFSPKVRTI-----LGEVNLMIKGYNFGN
ELTQNMEVYVGGKSCQVLHRNFTDI-RCLLPKL-------SPGKHDICVEVRNWGFAST

ENSGT00780000121902_0_Linker_7_8 (1440, 1453)

R
YDKSSASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTNMFPQKGSLYGGTE-VTIMGLGFSTIPTENTVLLGSFPCNVTSSS
ETVIKCVL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNVFRITNNGEDSVHGLGYAWSPSVLNVSVGDTVTWLWRAHPYLRGIGY
SVFSVSSPGSVIYDGKGFTNGREKSASGSFSYQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETSHIPLHLFVGGTEATYAQ----GRPVSLHLGSSVAGCQAREPLCGLNSTRAENS
ERLLFELSSCLS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISHISPSIGTLNELITITGRGFSNLTCANKV-KIGSYPCVVEESSN
ISLVCRIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTVTVYNLGTAINTLSSEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMISPNAASTT
GMTKVTIKGSGFAVSSAGAQVLMGHFSCKVLSVNYTAIECETSPAPQQLVKVNLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1879)

YLESIAVF

PF01833 // ENSGT00780000121902_0_Domain_11 (1879, 1956)

VTRIFPNSLQ-GSETVLIEGEGFGTALEDISVFIGNQQFRAV
DVNENNITVLMTPLPAGLHSLSVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVTPTSGSIGGGTTLMV
TGNGFSPGNTTVTVGGEPCQILSVNSSDIHCRTPAGTAGRVSVKVSVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLKGIVPST-GPPETEIQVTGSNFGTDILEISVMISSMQCNVTKVNDTVLQCIVG
DHAGGTFPVTMHHKTKGFAMSAVVFK

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIDSIHPSQG-SFGGGQTMTVTGTGFNPQNS
VVLVCGSKCAVDKLKSNRTTLLCDIPPSNG-RGPEQACEVSV---VNGKDSSPSTATFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
NMSMT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PFITKIAPKRGSTAGGTRLTVSGSGFSENVEDVLVTVAEATCDVEYSNKTCIICM
TNAHSPSGWAPVHVSIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

STGLAKRANADFLYVDTWSSNSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQI
ILLDQNTPILKMLLIQGGTLIFHEADIELQAENILITDGGILQIGTEAAPFQHRAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTRLAHTAKAGERTLILQEAVTWKPGD
KIVIASTGHRHSQRENEERTIASVSADGRNITLTDPLNYTHLGITVTLPDGTLFEARAEI
GILTRNILIRGSDNMEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSNQFGGCIMLHA
PLAGANMVTGRIENVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVKGCAIHQTYNRAITI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVHQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSSVPVPAVFHSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNGKIVGHLDELGMGSAFCTTKGLVLPFNEGLTVSSVHFMN
FDRPSCAALGVTSITGVCNHRCGGWSAKFTGIQYSHTLNKAGFRWEHEVVLIDVDGSLTG
HKGHTVIPHSPLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGKNDLHQSQSI
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNNSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTIPYPGANVVIPEGTWIVADTDIPPMERLVIRGVLELEDK-HNVGAAESSYRKVVLNAT
YISLQGGRLIGGWEDSPFKGELQIVLRGNHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
HSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDTLSYTHFAERYHVPGTSQSYTLAADVGILSRNIKILGEDYPGWLKESFGARVLVSS
FTENMVTFKGNAR-ISNVEFYHSGQEGFRDTTDPRYAVTFLNLGQIQER

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYVRGCAFH
NAFSPAIGVFGTDGLDIDDNVIHFTVGEGIR-IWGN-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSGQSNSLEKWFDNEAHGGLF
GIYMNQDGLPGCSLI-----QGFTIWSCWDYGIYFQ----------------TTESVHIY
NVTLIDNGMAIFSMIYMPSAVSHKISSKTVQIKNSLIVGSSPEFNCSDVLTNDDPNIELS
AAHRSSRPP--------------------S--GGRSGICWPTFSSAHNLAPRKPHAGIMS
YNSISGFLDISD--TTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDLSKVNPSDCVDMVCDAKRKSLLRDMDGSFLGNSGSVIPEAEYEWNGNSQFGIG
DYRIPKAMLTFPNGSRIPVTEKAPYKGIIRDSTCKYIPEWQGHRCFGMEYAMMVIESLDS
DTETRRVSPVAIVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALGKSYEVYFTG
TSPQNLRLMLLNVDHDKAVLVGIFFPTRQRLDVYVNNTLVCPQNTVWNSQQKYCEPT--R
QPYTEQLLPNLNSTALGENYFDRTYQMLYLLVKGTIPVEVHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSKVIRGESLR--RKRSM-ELTVELEIGDPPPQFITKD
TTGQ--MQLP-ELQEI--ADSLGQAVILGKTNSILGFNVSSMSITDPIPSPNDSGWAKVA
AQPVGRLS--FPVHHVAFVTSLSVITQPVATQLGQPFSQQPSIKAEDADGNCVSVGITAL
PLKAVLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TLLRTGKNFKIEFILDEFVRV-
----ESQPLSLASQSVSSPGSGSSG--------------------SSNSRASTVGTAAQI
VTTVISCLVGRVLLLEIFMTAVLTLNVL--------------------------------
-------------

----------------------------MGH-LW--LVGA---WGLWGL-------LLSA
ADSHTD-----GSKLI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PKVTEVIPKYGSVNGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSIACDVEKDSSHSTQITCYTRAMPEDSYAVRVSVDGVPIG

ENSGT00780000121902_0_Linker_1_2 (169, 212)

ENNTCKGRVNSW
ACSFNR-------AAK-------------PL

PF01833 // ENSGT00780000121902_0_Domain_2 (212, 313)

STLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPQSDDLYGLKLHHPNGDMGSMICKITGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 355)

YFVSSLNKI-SMFQTF-----------------------AEV

PF01833 // ENSGT00780000121902_0_Domain_3 (355, 426)

AMVSPS
KGSIQGGATLT-INGRFFDQTDVPVRVLVGGQP----CDILNITENSICCKTPP-RPH-S
LKTVY

ENSGT00780000121902_0_Linker_3_4 (426, 452)

PGGRGLKLEVWNRSRPAHLEEILGYG

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

ENTPGYMGATWIDSASYTWPMEHDTFVAR
FSGFLVVPDSDVYRFYIRGDDHYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
DIYLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYKSVYSEQQTGDAINEEQVIKSQSTIIQE
VQVITLENWETTIATNEVQKITVTSPCMDANSCSHYQYRLIYNTEKT----VLLPADASE
VILQSALNDLWSIKPDTVQVIRT-QALQSRIYTITFISNRGDFDLLGYEVFEGNNVTVDI
TEQTKGKPSLETFTLNWDGILSKPLTPRSSEAEFQVAVEEMVSTKCPPQIAHFEEGFVVK
YFRDYETDFDLENVNRGQKTAETDAYCGRYSLKNPSVLFDSADAKSNRLPYGNILLFPYN
QLCLAYKGFLANYIGLKFQYQDS-GKITRSKDTQFIYNFAHGK-SWTYTCLDLLDLIQSK
QTGMNFSLQRISLQKASETQSFYVDVVYIGQVSTTSTLDEMAKRRLPALANKGIFLKQFQ
VNQSKKDESTMTIQYSVTMMSYNCSYNIPMMAVSFGQIIANETENESVYRGNNWPGESKI
RIQRIQEASPPISGSFDIQAYGHVIK-GIPATVSAADLQFALQSLEEVGRVSVTREGTCA
GFSWGITWRSACGKQNLLQINDSNIIGEKANM--TVTKIKEGGLFRQRILGDLLRTPHQQ
TQVEVYINGIPAKCSGDCSFTWDSTAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PQVLAISPSQGSYEESTILSIVGSGFSPSS---
AVSVSVGSTGCSLLSVD-E-NEIKCQIVNGSAGHLPVAVSVA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DVGLAQNVDS-KGFHFIY
QSQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1337)

LSHIWPDSGSLA-GGTVLTLSGFGFSENSEVLVGNETCSVIEGNLNRITCRTPKRSE
GTVDISVITNGFQATS

ENSGT00780000121902_0_Linker_6_7 (1337, 1348)

RNIFRYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVIMDFSPKIRTI-----LGDVNLTIKGYNFGN
ELTQNVVVYVGGKTCQILHWNFTDI-RCLLPEL-------SPGKHSVHVEVRNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1453)

FAST-
SDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTDMSPHRGSLYGGTE-ITIMGLGFSTIPTENTVLLGSFPCNVTSSS
ENTIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGKVFRITNNGEDLVHGLGYAWSPSVLNVSVGDTVAWHWQAHPFLRGIGY
RVFSVPSPGSVSYDDKGFTNGRPKSSSGSFSYQFTLPGIHYYSSGHVDEARSVSLQGVIN
VLPAKTRHLPLQVFVRSTEATYTR----GGPENLHLGSSVAGCLATEPLCSLNDTRVKDS
NIFLFELSSCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1754)

PSISNITPSTGTVNELITITGSGFSNLTCANKV-TIGRYPCVVEESHD
SSITCHIDPQNSM

ENSGT00780000121902_0_Linker_9_10 (1754, 1787)

EVGIRDFVTLVVYNLGTAINTLSSEFDRQFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIEMVLPNTGSTT
GMTRVIIKGSGFAGSSAGVEVLMGHFPCKVLTVNYTAIECETSPAPQQLVLVHLLIRGVP
ALCQGSCNFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PCVTGIFPDSVR-GPVKVVIEGEGFGTVLEEVAVFIGNQQFRAI
HVNESNITVLVPSLPAGLHSLRVVVETKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PMVASVSPTSGSLGGGTMLVI
TGNGFHLDNTTVTVGEAPCQIMFANSSKVHCSTPAGKAGKTNLQILVNEVPYPALSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YS
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGISPNT-GPPGTEIEITGSNFGFNISEISVRISDAGCHVTMVNDSVLQCVAG
DHAGGTFPVVLYHKTKGFAVSTLVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQSIHPQQG-SFGGGQTLTVTGAGFNPQGS
VPLICGSECATDRLRSDYTTLLCEIPPNDG-MGPEQACEVSV---VNGRDSSPSTALFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLVTEISPRKGSTSGGTRLTVWGSGFSENPQDVDITIAEAECDVKYANKTHIICV
TSAHTPSGWAPLHVNIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

NIGMAKLKNADFLYMDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLAVITKGQI
LLLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHPRSPELPVYGAKTLAVREGTLDLHGLPVPVVWTRLAQTAKAGEWTLILQEGVTWKAGD
SIVIASTGHRHSQRENEERTIASVSADGVNITLTQPLNHTHLGTSVTLPDGTVFEARAEV
GILTRNIVIRGSENVEWNNKIPACPSGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PLPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRNCAIHQSYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDPHICQKRIPLGEFFNNTVHSQGWFGLW
IFEDYFPMKTGSCTSTAPLPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILASYVGGWSETNGAVVKNAKIVGHLDELGMGSAFCTSKGLVLPFSDGLTVSSVRFMN
FDRPNCVALAVTSITGVCHDKCGGWSAKFVDIQYFHTPNKCGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSLLLDPSHCTQETQWSIGFPGSVCDASVSFHRLAFNKPCPISLLEKDVILS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDVGHITNISYTSTFYGFKEEDYVI
ISHNFTQNPVMFSVIDVRNGSSNPLNWNTSKNGDWHLDANTSTLYYLVSGRHDLQQSQSI
SGTLDPDVKDVVINFQAYCCSLQDCFPVHSPSRKPIPRKRPATYNLWSNHSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGAHVVIPEGTWIVADIDLPPMERLLVWGVLELEDK-SSDGAAEPSYRTVVLNAT
YISVQGGRLIGGWEDNPFRGELHIVLRGNHSTPEWALPGGPNQGAKVLGVFGELDLHGLP
HLIYKTKLSETAEAGSRVLSLTDAVDWKEGEEIVITTTSYDLYQTETRSIVKILHGHKIL
ILNDSLSYNHLAKRHYVPETGQSYILAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYVRGCAFH
HGFSPAIGVFDTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRRNLVTLSVWPGSYQDRKD
LSSTLWHAAIEINKGTNTVLQNNVVAGFGRVGYHIDGEPC--------------------
---------------------GFTIWTCWDYGIYFQVNGIKGVLFHLLFLLQTTEHVHIY
NVTLVDNGMAIFSMIYMPAAVSHKISSKTVKVESTLIVGSSPEFNCSDVLSNDDPNIELT
DAHRSAR----------------------PPAGGRSGICWPTFASAHNMAPRKPHAGIMS
YSAIS------G--STFVGFKNVCSGETNVIFMTNPLNEDLQHPIYVKNVQLVDTTEPSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDTDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPKAMLTFLNGSRIPVTEKAPYKGIIRDATCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFYSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNRAVLVGIFYSTLQRLDVYVNNSLVCPKNTIWNAEQKRCKLN--M
HLYAEQFLPKLNSTILGENYFDRTYQMLYLLVKGTAPVEIHTAAVIFVSFRLPAVTEDDF
YSSQNLVRNLALFLNIPSDKIRVSKIIRGKSMR--RKRST-GQTIELEIGDPPIQFLSND
TPGR--MKFS-ELQEI--SGSLGQAVILGKISSILGFNISSMSITNPIPSPNDSGWTKVT
AQPVARSA--YPVHHVALVTSLCVITQPVTAQPGQPFPQQPSVKAVDPDGNCVSVGITSL
TLKAVLKDSSNNQISGLGGNTTIPFSSCWANYTDL---TPLRTGKNYKLEFLLDNVVRA-
----ESRTFSLLVQSASGDSSS-TSSSS---------S---GGSGGSHSKASTVGTSAQI
MAILISCLMGRMLLSEILMAAAFILNINVGK-----------------------------
-------------

----------------------------MGH-LW--LLGT---WCFWGL-------LLCA
VDPRT-----DGSKIIPRVTEIIPKYGSINGATRLTIKGEGMVVFFVV------------
-------VVVFCFLPRLRYLKTISHLELYAMPEDSYTVRVSVDGVPIAENNTCKGHINSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRLNVVG----------AYKYGLKLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSLPQRMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTTISPS
QGSIRGGTVLT-ISGQFFDQTDFPAKVLVGGQA----CDILNVTENSIRCKTPP-KPH-I
LKTVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 443)

GLKLEVWNNSRPV

PF07691 // ENSGT00780000121902_0_Domain_4 (443, 558)

HLEEILEYNEKTPGYMGASWVDSASYSWPMEQDTFVAR
FSGFLVVPESDVYIFYIKGDDRYALYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
GIHLQKGKEYYVEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYRTVYTEQQTGDAINEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKITSPCVEANSCSLYQYRLIYNVEKT----VLLPADASD
FLLQSALNDLWSIKPDTVQVTRT-QNPQSYIYTITFISTRGDFDLLGYEVFEGNNVTLDI
TEQTKGKPSLETFTLNWDGIASKPLTPQSSEAEFQVAVEEMVSTKCPPEIANFEEGFVVK
YFRDYETDFNLNNINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLTNYIGVKFKYQDN-GKITRSTDKRFIYNFADGN-NWTYTCIDLLDLIQTK
YTGTNFSLQRISLQKASESQSFYVDIVYIGQTPTISTLDEMPKRRLPALANKGIFLKHFQ
VNQTKTNGSAIMNQYSVTMTSYNCSHNIPMIAVSFGQIITHETENESVYRGNNWPGKSKI
RIQRIQAASPPLSGSFDIQAYGHNLK-GLPAAVSAADLQFALQSLEEMGRVSVTREGTCS
GYSWNIQWRSTCGKQNLLQINDSNIIGEKANV--TVTKIKEGGLFRQHILGDLLRTPSQH
PQVEVYINEIPAKCSGDCAFTWDSTIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1247)

PLVLATSPSQGSYEESTILTIVGSGFSPNS---
AVSVSVGPIGCPLLSVD-E-NEIKCQILNGSAGRALVAVSVAGVGL

ENSGT00780000121902_0_Linker_5_6 (1247, 1263)

AQNVGA-ETFHFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISRIWPASGSLA-GGTLLTLSGFGFNENSTVLVGNETCNVIEGDWNRITCRTPKRIE
GTVDISVIANGFQATAKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PVITDFSPKVRTI-----LEEVNLTIKGYNFGN
ELTQHMVVYVGGKTCQILHWNFTNI-SCLLPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1511)

EVTNMFPQRGSLYGGTE-ITVMGFGFSPIPTENTVLLGSFPCNVISSS
EKIIKCTLHS

ENSGT00780000121902_0_Linker_8_9 (1511, 1693)

TGSAFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVTWHWQTHPFLRRIGY
RVFSVSSPGSVIYDGKGFTNGRQKSKSGSFSYQFTSPGIHYYSSGYVDEANSIFLQGVIN
VLPAESRHIPLHLFVGSTEATYAQ----GGPEILHLGSSVAGCLATEPLCGLNNTGVKNS
KRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSTGTVNELITITGHGFSNLTCANKV-TIGGYPCVVEESND
SSIMCHIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTLTVYNLGTAINILPSEFYRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPSAGSTT
GMTRVTIKGSGFAVSSAGVEVLMGRFPCKVLSVNYTAIECETSPAPQHLVVVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITRIFPDSIQ-GSERVLIEGEGFGTDLEEIAVFIGNQQFRAI
DVSENNITVLVTPLPAGLHSISVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIGGGTILVI
TGNGFYPGNTTVTIGDDPCQIISVNTSEVYCYTPAGTAGMVGVKIFVNAIAYPPLPFT

ENSGT00780000121902_0_Linker_12_15 (2039, 2063)

YA
LEDTPFLRGIVPSR-GTPISLT

PF10162 // ENSGT00780000121902_0_Domain_15 (2063, 2438)

VWI---------------S-------------------
------------------------------------------------------------
----------------------------------------------NGSK----------
-----------------------LD-----------------------------------
------------------------------------------------------------
SFNSQPCVYFKIIWFIGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTRLAHTAKAGERTLILQEAVTWKAGD
NIVIASTGHRHSQRENEKRTIASVSADGINITLTNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIKGSDNVEWNNKIPPCPDEFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGMNMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFMMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSAGLTVSSVHFMN
FDRPNCAALGVTSITGVCNERCGGWSAKFVDIQYFHTPNKAGFRWEHEVVLIDTDGSLTG
YKGHTVIPHSSLLDPSHCTQEAEWSIGFAGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNSNHINWYFKDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDIRNGSLNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHPSQPT
SGTLDPDVKDVTINFQAYCCILQDCFPIHPPSRKPIPRKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3288)

WQSSRENN
YTVPHPGSNVVIPEGTWIVADTALPPMERLIIWGVLELEDN-YSVGAVESSYRKVVLNAT
YISLQGGRLIGGWEDDPFKGELKIVLRGNHSTPEWALPEGPNQGAKVLESTLKYT-----
--------------ALKYL-SVHDVTVSEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLGKWLLPSSESQE--LGA--------------------------------
--DRNVKLEKPFR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQVCTLFLTF-------
------------------------------------------------------------
---VFIKNMQNINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSQSNSKEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYTPAAVSHKISSKKVKIKSSLIVGSSPEFNCSDVLTDDDPNIELT
AAHRSPRPP--------------------T--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAIGGLLDVSG--STFIGFKNVCSGEINVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKYILEWQSYKCFGMEYAMMVIESLDS
DTETRRLSPVAVLSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVVVGTFFSTLQRLDVYVNNSLVCPKTTVWNAQQKYCELN--K
HLYTEQFLPDLDSTVLGENYFDRTYQMLYLLVKGTLPVEIHTTTVIFVSFQLPTVTEDDF
YSSHNLVRNLALFLKIPSDKIRISKVVRGKSLR--RKRST-GLAIELEIGDPPTQFLSND
TTGR--MQLS-ELQEI--ASSLGQAVILGKTGNILGFNISSMSITNPLPSPSDSSWIK--
-----------------------------------PFSQQPSVKAVDSDGNCVSVGVTML
TLKAILKDSNNNQVSGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVRV-
----ESRTFSLPAQTVSSSSSSGG--------------------SSSSSKATTVRTSAQI
MIIVISCLMGRMLLLEIFMAAVFALNVTIGKYNSF---FI--------------------
-------------

----------------------------MGH-LW--LLGI---WGLWRL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYAVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVTENNTCKGHINSW
ACTFNA-------KCFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGMPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNKI-SMFQTY-----------------------AE

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 417)

VTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDTLNVTEKSICCKTPP-K

ENSGT00780000121902_0_Linker_3_4 (417, 447)

PH-I
LKAVYPGGRGLKLEVWNNSRPIHLEE

PF07691 // ENSGT00780000121902_0_Domain_4 (447, 557)

ILEYDEKTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYISQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKTVQSKVFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLGYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDIQFTYVFAHGN-NWTYTCIDILDLIRTK
YTGTNVFLQRISLQKASESQSFYVDVVYIGQTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNRTKTNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
LIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSAADLQFVLQSLEALGRVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1246)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGHAPVAVSVADVG

ENSGT00780000121902_0_Linker_5_6 (1246, 1263)

LAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTAGDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIHVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYVDEARSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAQ----GGPENWHLGSSVAGCLATEPLCGLDSTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSTGTVNELITIIGHGFSNLTCANKV-TIGSYPCVVEESSE
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVVSVDYTSIECETSPAAQQLVDVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1951)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDVAVFIGNQQFRAI
EVNENNITALVTPLPVGHHSLSVVVGSKGL

ENSGT00780000121902_0_Linker_11_12 (1951, 1962)

ALGNLTVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINPNEVNCRTPAGTTGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGTEILEISVMINNIQCNVTTANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2300)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHITIAEAKCDVEYSNKTHIICM
TDAHTPSGWAPVRVHIRGV

ENSGT00780000121902_0_Linker_15_16 (2300, 2320)

GMAKLDNADFLYIDAWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2438)

SWGGQSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLALFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRHICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFLTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSDPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSQENN
YTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKLSETADAGSNVLCLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIVGEDYPGWSEDSFGARILVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCPGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSFI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------SVKGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IYIHRPDISKVNPSDCIDMVCDAKRKSFLRDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLINDLGPQDHGWCAGYACQRRLSLFHSIVALNTSYEVYFTG
TSPQNLRLMLLNADHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTLWNAQQKHCELN--N
HLYKDQFIPNLDSTVLGENYFDRTYQLLYLLVKGTIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPRDKIRISKTIRGKSLR--RKRSM-GFIIEIEIGDSPIQFLSNG
TTGQ--MQLS-ELQEI--ASSLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSSSS-----------------SSGSSSNSKASTVGTYAQI
ITVVISCLIGRMWLLEIFMAAVSTLKITLRSY----------------------------
-------------

----------------------------MRH-LW--LWAA---WGLWGL-------LLCA
AEPRT-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 175)

PKITETIPKYGSINGATRLTIKGEGFAQANQFNYGVENAELGNS
VQLVSSFQSISCDVEKDASHSTHITCYTRAMPEDSYTVRVSVDGIPITENNTCK

ENSGT00780000121902_0_Linker_1_2 (175, 199)

GHINSW
ACSFSA-------RSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGSPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLIPQSDNLYGLKLDHPNGDLGSMICKTTGTYVG--HHNVSFILD-S
DYGRSLPQKTT-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 450)

AEVTRISPS
HGSIQGGTTLT-ISGRFFDQTDLPVRVLVGGQA----CDILNITENSIYCKTPP-RPH-L
PRTVYPGGRGLKLEVWNNSRPVRLEEVLEYNENTPGYMGSSWVDSASYAWPMDQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSQTELPDD--KVRIAYHSANANSYFSSPTQRSDEIHLQKGKEYYFEILLQEYRLSAFVDVGLYQSRNVYTEQQTGDAVNEEQIIKSQSTVIQEVQVITLENWETTNATNEVQKITVTSPCVKDNSCSLYQYRLIYNTEKTFHPKVLLPADASDLVLQSALNGLWSIKPDTVQVIRT-QNPESYTYMITFISTRGDFDLLSYEVFEGNNITLDITEVTKGKPSLETFTLSWDGIASKPLTPWSSEAEFQAAVEEMVSAKCPPQIANFEEGFEVKYFRDYETAFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYNQLCLAYKGFLANHIGLKFQYQDS-TKTTRSMDVQFPFNFAGGN-NWTYTCVDLLDLIQTKYAGTNFSLQRISLQKASQSESFYVDIVYIGQTSTISTLDELPKRRLPALTSRGIYLKHFQVNRTKINGSTMTNQYSVTMTPYNCSYHIPMMATGFGQIITNETENESVYRGNNWPGESQIRIQRIQAASAPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLGEMGRVSVTREGTCAGYSWTIKWRSMCGKQNILQTNDSNIIGEKANM--TVTKIKEGGLFRQRILGDLLRTPNQQPQVQVYVNGIPAKCSGDCEFTWDPMTTPLVLAINPSQGSYEESTILTISGSGFSPSS---AVSVSVGPIGCSLLSVN-EEKEIKCQIQNGSAGHFPVAVSIADVGLAQNVKD-EVFHFTYQSHISHIWPD------------------------------------------------------------GFQATANDAFSYNCLQTPVITDFNPKERAILGKKIIGEVYLTIKGYNFGNELTQNM-VYVGGKTCQVLHWNVTDI-RCLLPKL-------PPGKHDVYVEVRNWGFASK-RDKLHVSIQYILEVTNMFPQRGSLYGGTE-ITIMGFGFSTIPAENTVLLGSFPCNVISSSASVIKCVLHSTGNAFRVTNNGEDSEHGLGYAWSPSVLNVSVGDTVTWRWQAHPFLRGIGYRVFSVSSPGSVIYDGKGFTSGRQKSASGSFFYQFTSPGVHYYSSGYVDDANSIFLQGVINVLPAETRNIPLHLFVDSTEATYVQ----GGPENLNLGSSVAGCLATEPVCGLNNTGVKNSDRLLFELSSCFSPSINNISPSIGTVNELITVTGHGFSNLTCANKV-TIGSYPCVVEESNEYSIMCHIDPQNSMDVGIREVVTLTVHNLGTAINTLASEFDRRFVLLPSIDMVLPLAGSTTGMTKLTIKGSGFAASPANVDVLMDRLPCKVLSVNYTAIECETPPAPQHLVDIALLIHGVPAQCQENCSFSYLDSLTPILTRIIPDSIN-GSVQVLIEGEGFGTILQDIAVFIGNQQFRAIDVNENHITVLVTPLPAGLHSLSVVVGTKGLALGNLTVSSPAVASVSPTSGSTGGGTTLSITGNGFYPGKTTVIVGDNPCEIISVNFSEVYCHTPAGEAAMVDVKVFVSEVAYPPLSFTYAVEDTPFLGGIVPSR-GPPGTEIQITGLNFGIDVLEVSVMISNTQCNVTTVNDSVLNCIVGDHAGGTFPVTMHHQTKGSAVSRVIFEYPLTIQNIHPSQG-SFGGGQTMTVTGTGFNPQNSVILVCDSECAVDKLRSGYTTLLCNIPPNNG-SGPEQTCEVNV---VNGKDLSQAPTPFTYNVSLTPLITEIAPKRGSTAGGTRLTVMGSGFSEDMQDVHVTIAEAECDVVYSNKTHIICMTNAHAPSGPAPVHVNIRSIGLAKLGNAEFLYVDAWSSNFSWGGKSPPEEGSLAVITKGQTILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLHGHLRSPELPIYGAKTLAVREGVLDLHGLPVPVIWTRLAQTAKAGERTLVLQEAVTWKAGDDIVIASTGHRHSQRENEKRTIASVSADGVNITLTNPLNYSHLGTTVTLPDGTLFEARAEVGILTRNILIKGSGNVEWNDKIPACPDEFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHAPVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTIHNTHHLLIERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGIWIFEEYFPMQTGSCTSTEPVPAIFNSLTTWNCQKGAEWVHGGALQFHNFVMVNNYEAGIETKRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGPAFCTMKGLLLPFSAGLTVSSVHFMNFDRPSCVALGVTSITGVCNDRCGGWSAKFVDIQYFNTPNKAGFRWEHEMALIDVDGSLTGHKGHTVIPHSSLLDPSHCTQEPEWSIGFPGSVCDDSVSFHRLAFNKPSPVSLLEKDVVLSGSFGTSIVPFQKKRLTHMSGWMALIPNADRINWYFKGVDHITNISYTSTFYGFKEEDYVIISHNFTQNPVMFNIVDMRNASSNALDWNTSKNGDWHLEANTSTLYYLVSGRNDIQQSQPISGTLDPDVKDVTINFQAYCCVLQDCFPVQPSSRKPLPRKRPATYNLWSNDSFWQSSRENNYTIPHPGANVVIPEGTWIVADTDIPPMERLIIWGILELEDK-HSMGDAASSYRRVVLNATYISLQGGRLIGGSEDKPFKGELQIVLRGNHSTPDWALPKGPNQGSKVLGVFGELDLHGIPRSIYKTKLSETAEAGSKALSLVDAVDWQEGDEIVITTTSYDSQQTETRSIVKILHDHKVLILNDTLSYTHLAEKYHIPGTGQSYTLAADVGILSRNIKIIGEDYPGWVKESFGARVLISSFTENMMTFRGKAR-ISNVEFYHSGQEGYRDSTDPRYSVTFLNLGQIQEHGSSYIRGCAFHHGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVSLSVWPGTYQDRKDSSSTLWHAAIEINRGTNTVLQNNVVAGFGRSGYRIDGESCSSQSNRMEKWFDNEAHGGLYGVYMNEDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIYNVTLVDNGMAIFPMIYLPAAVSHKISSKKVQVKSSLIVGSSPAFNCSDVLRNDDPNIELTAAHRSSRPP--------------------SVKGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLEISG--LTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSKILIHRPDISKVNPSDCVDMVCDAKRKSFLKDMDGSFLGRSGSVIPQAEYEWNGNSQLGIGDYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDATCKYIPKWQSYRCFGMEYAMMVIESLDSDSETRRLSPVAIVSNGYVDLINDVGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTGTSPQNLRLMLLNVDDNKALRVGIFFSTLQRLDVYVNNSLVCPKNTVWSPQQKRCELN--RHLYTEQSLPTLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTVAVIFISFQLPAVTEDDFYSSQNLVRNLALFLNIPSDKIRVSNIIRGKSLR--MKRSR-RLIIELEIGDPPTQIINNGTADQ--MQLS-ELQEV--ADSLGQAVILGKISTVLGFNISSMSITNPIPSPSDSGWNKVTAQPIERSA--FPVHHVAFVFSLSVIAQPVTAQPGQPFSQQPSVKAVDSDGNCVSVGITSLTLKAILKDSSNNQISGLSGNTTIPFSSCWANYTDL---TLLRNGKSYKIEFILDNVTRV-----ESSTLSLPVQSISKASPR--------------------------------G-PAAYLTVVISCLIGRMLLLEIFVATVLILNQTEIVN------------------

PF07691 // ENSGT00780000121902_0_Domain_4 (427, 583)

GGRGLKLEVWNNSRPVRLEEVLEYNENTPGYMGSSWVDSASYAWPMDQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTELPDD--KVRIAYHSANANSYFSSPTQRSD
EIHLQKGKEYYFEILLQEYRLSAFVDVGLYQSRNVYTEQQTG

ENSGT00780000121902_0_Linker_4_5 (583, 1168)

DAVNEEQIIKSQSTVIQE
VQVITLENWETTNATNEVQKITVTSPCVKDNSCSLYQYRLIYNTEKTFHPKVLLPADASD
LVLQSALNGLWSIKPDTVQVIRT-QNPESYTYMITFISTRGDFDLLSYEVFEGNNITLDI
TEVTKGKPSLETFTLSWDGIASKPLTPWSSEAEFQAAVEEMVSAKCPPQIANFEEGFEVK
YFRDYETAFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANHIGLKFQYQDS-TKTTRSMDVQFPFNFAGGN-NWTYTCVDLLDLIQTK
YAGTNFSLQRISLQKASQSESFYVDIVYIGQTSTISTLDELPKRRLPALTSRGIYLKHFQ
VNRTKINGSTMTNQYSVTMTPYNCSYHIPMMATGFGQIITNETENESVYRGNNWPGESQI
RIQRIQAASAPLSGSFDIQAYGHILK-GLPAAVSAADLQFALQSLGEMGRVSVTREGTCA
GYSWTIKWRSMCGKQNILQTNDSNIIGEKANM--TVTKIKEGGLFRQRILGDLLRTPNQQ
PQVQVYVNGIPAKCSGDCEFTWDPMTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1260)

PLVLAINPSQGSYEESTILTISGSGFSPSS---
AVSVSVGPIGCSLLSVN-EEKEIKCQIQNGSAGHFPVAVSIADVGLAQNVKD-EVFHFTY
QSHISHIWPD--------------------------------------------------
----------GFQATANDAFSYNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1444)

PVITDFNPKERAILGKKIIGEVYLTIKGYNFGN
ELTQNM-VYVGGKTCQVLHWNVTDI-RCLLPKL-------PPGKHDVYVEVRNWGFASK-
RDK

ENSGT00780000121902_0_Linker_7_8 (1444, 1452)

LHVSIQYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVTNMFPQRGSLYGGTE-ITIMGFGFSTIPAENTVLLGSFPCNVISSS
ASVIKCVLHSTGNAFRVTNNGEDSEHGLGYAWSPSVLNVSVGDTVTWRWQAHPFLRGIGY
RVFSVSSPGSVIYDGKGFTSGRQKSASGSFF

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGVHYYSSGYVDDANSIFLQGVIN
VLPAETRNIPLHLFVDSTEATYVQ----GGPENLNLGSSVAGCLATEPVCGLNNTGVKNS
DRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1779)

PSINNISPSIGTVNELITVTGHGFSNLTCANKV-TIGSYPCVVEESNE
YSIMCHIDPQNSMDVGIREVVTLTVHNLGTAINTLASE

ENSGT00780000121902_0_Linker_9_10 (1779, 1787)

FDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PSIDMVLPLAGSTT
GMTKLTIKGSGFAASPANVDVLMDRLPCKVLSVNYTAIECETPPAPQHLVDIALLIHGVP
AQCQENCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDSLT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

PILTRIIPDSIN-GSVQVLIEGEGFGTILQDIAVFIGNQQFRAI
DVNENHITVLVTPLPAGLHSLSVVVGTKGLALGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSTGGGTTLSI
TGNGFYPGKTTVIVGDNPCEIISVNFSEVYCHTPAGEAAMVDVKVFVSEVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
VEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLGGIVPSR-GPPGTEIQITGLNFGIDVLEVSVMISNTQCNVTTVNDSVLNCIVG
DHAGGTFPVTMHHQTKGSAVSRVIFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTIQNIHPSQG-SFGGGQTMTVTGTGFNPQNS
VILVCDSECAVDKLRSGYTTLLCNIPPNNG-SGPEQTCEVNV---VNGKDLSQAPTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
NVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITEIAPKRGSTAGGTRLTVMGSGFSEDMQDVHVTIAEAECDVVYSNKTHIICM
TNAHAPSGPAPVHVNIRSIGLAKLGNAEFLYVDAWSSNFSWGGKSPPEEGSLAVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPIYGAKTLAVREGVLDLHGLPVPVIWTRLAQTAKAGERTLVLQEAVTWKAGD
DIVIASTGHRHSQRENEKRTIASVSADGVNITLTNPLNYSHLGTTVTLPDGTLFEARAEV
GILTRNILIKGSGNVEWNDKIPACPDEFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLIERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSTEPVPAIFNSLTTWNCQKGAEWVHGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGPAFCTMKGLLLPFSAGLTVSSVHFMN
FDRPSCVALGVTSITGVCNDRCGGWSAKFVDIQYFNTPNKAGFRWEHEMALIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEPEWSIGFPGSVCDDSVSFHRLAFNKPSPVSLLEKDVVLS
GSFGTSIVPFQKKRLTHMSGWMALIPNADRINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPVMFNIVDMRNASSNALDWNTSKNGDWHLEANTSTLYYLVSGRNDIQQSQPI
SGTLDPDVKDVTINFQAYCCVLQDCFPVQPSSRKPLPRKRPATYNLWSNDSFWQSSRENN
YTIPHPGANVVIPEGTWIVADTDIPPMERLIIWGILELEDK-HSMGDAASSYRRVVLNAT
YISLQGGRLIGGSEDKPFKGELQIVLRGNHSTPDWALPKGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETAEAGSKALSLVDAVDWQEGDEIVITTTSYDSQQTETRSIVKILHDHKVL
ILNDTLSYTHLAEKYHIPGTGQSYTLAADVGILSRNIKIIGEDYPGWVKESFGARVLISS
FTENMMTFRGKAR-ISNVEFYHSGQEGYRDSTDPRYSVTFLNLGQIQEHGSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVSLSVWPGTYQDRKD
SSSTLWHAAIEINRGTNTVLQNNVVAGFGRSGYRIDGESCSSQSNRMEKWFDNEAHGGLY
GVYMNEDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYLPAAVSHKISSKKVQVKSSLIVGSSPAFNCSDVLRNDDPNIELT
AAHRSSRPP--------------------SVKGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLEISG--LTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
ILIHRPDISKVNPSDCVDMVCDAKRKSFLKDMDGSFLGRSGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDATCKYIPKWQSYRCFGMEYAMMVIESLDS
DSETRRLSPVAIVSNGYVDLINDVGPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDDNKALRVGIFFSTLQRLDVYVNNSLVCPKNTVWSPQQKRCELN--R
HLYTEQSLPTLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTVAVIFISFQLPAVTEDDF
YSSQNLVRNLALFLNIPSDKIRVSNIIRGKSLR--MKRSR-RLIIELEIGDPPTQIINNG
TADQ--MQLS-ELQEV--ADSLGQAVILGKISTVLGFNISSMSITNPIPSPSDSGWNKVT
AQPIERSA--FPVHHVAFVFSLSVIAQPVTAQPGQPFSQQPSVKAVDSDGNCVSVGITSL
TLKAILKDSSNNQISGLSGNTTIPFSSCWANYTDL---TLLRNGKSYKIEFILDNVTRV-
----ESSTLSLPVQSISKASPR--------------------------------G-PAAY
LTVVISCLIGRMLLLEIFVATVLILNQTEIVN----------------------------
-------------

----------------------------MGH-LW--LWGT---WALWGL-------LLCV
ADPRT-----DGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 175)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFRSISCDVEKDSSHSTQITCYTRAMPEDSYTIRVSVDGVPIAENNICK

ENSGT00780000121902_0_Linker_1_2 (175, 199)

GHINSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTIITIQGRIFTDVYGSNIALSSNG-KNV
RILRAYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTYIGKCHHNVSFILD-S
DYGRSLPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 379)

AEVTKVSPS
QGSIQGGTMLT-ISGRFFDETDFPVRVFVGXXX----XXXXXXXXXXXXXXXXX-XXX-X
XXXXXXXGRGLKLEVWNSSRPVHLEEILEYDEKTPGYMGTSWVDSASYLWPMGQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPED--KVRIAYHSSNANSYFSSPTQRSD
DIHLQKGKEYYIEILLQEYRLSAFVDVGLYQYRNVYTEQQTEDAVNEEQVIKSQSTIVQE
VQVITLENWETTNATNEVQKIMVTGPCVEANLCSLYQYRLIYNKEKT----VWLPADASD
FILQSALNDLWSIKPDAVQVIRT-QNPQSYVYMVTFISTRGDFDLLSYEVFEGNNVTLAI
TEQTKGKPSLDTFTLNWDGITSRPLMPQSSEAEFQAAVEEMVSAKCPPQIANFEEGFVVK
YFRDYETDFNLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XLCLAYKGFLANYIGLKFQYQDT-SKITRSTDTQFTYNFAYGN-NWTYTCIDLLDLIQTK
YTGTSFSLQRISLQKASESQSFYVDIVYIGQTSTIAALDEMPKRRLPALANKGIFLKHFQ
VNQTKINGSSMTNQYSVTMTSCNCSYNIPMMAVSFGQTITNETENESVYRGNNWPGESKI
RIQRVQAASPPLSGSFDIHAYGHILK-GIPAAASAADLQFALQSLEEVGQVSVTREGSCA
GYSWHVKWRSTCGKQNLLQINDSNIFGEKANV--MVTRIKEGGLFRRRILGDLLRTPSKQ
PQVEVYVNEIPAKCSGDCGFTWDPTTT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1260)

PQVWAISPSQGSYEESTILTVSGSGFSPSS---
TVSVSVGPAGCSLLSV--NENEINCQILNGSAGRFPVAVSIAGVGLAQNTEE-EELHFI

ENSGT00780000121902_0_Linker_5_6 (1260, 1262)

Y
Q

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

SQISHIWPASGSLA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGNLNKITCRTPKRIE
GTVDISVITSGFQAMAKNAYS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1444)

PVITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMEVYVGGKSCQVLHWNFTDI-RCLLPKL-------SPGKHDICVEVRNWGFASTR
-DK

ENSGT00780000121902_0_Linker_7_8 (1444, 1452)

LNASIQYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LQVTSMFPQKGSLYGGTE-ITIMGLGFSTILAENTVLLGSFPCNVTASS
ENVIKCVVHSTGKVFRITNSGEDSVHGLGYAWSPSVLNVSVGDTVTWHWQAHPYLRGIGY
RVFSVSSPGSVIYDGKGFTNKREKSASGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGIHYYSSGYVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGGTEATYAQ----GGPVNLHLGSSVTGCLATEPLCGLNSTGFAHS
DRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1777)

PSISNISPSIGTLNELITITGRGFSNLTCANKV-TIGSYPCVVEESSN
NSIVCHIDPQNSMDVGIREIVTVTVYNLGTAINTLS

ENSGT00780000121902_0_Linker_9_10 (1777, 1787)

SEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDVVLPNAGSTT
GMTKVTIKGSGFAVPSAGVQVLMGHFPCEVLSVNYTAIECETSPAPQQLVKVNLLIHGVP
ALCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1957)

AFVTRISPNTIK-GSVKVLIEGEGFGTILEDVSVFIGNQQFRAI
DVNENNITVLVTPLPAGIYPLSVVVGMKGLALGNLT

ENSGT00780000121902_0_Linker_11_12 (1957, 1960)

VSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PPVASVTPTSGSIGGGTTLMI
TGNGFYPGNTTVTVGDEPCQIISVNSSEVYCRTPAGTAGRVSVKISVNAVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLRGVIPST-GPPGTEIQINGSNFGIDILEISVMINNIQCNVTMVNDTVLQCIAG
DHAGGTFPVTMHHRTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2129)

YP

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

LTIHNIHPSQG-SFGGGQTMTVTGTGFNPQNS
VVLVCSSKCAVDRLKSNRTTLLCEVPPNNG-RGPKQACEVSV---VNGKNSSQSPAPFI

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMSMT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLITEIAPRRGSAAGGTRLTVLGSGFSENIQDVLVTIAEAKCDIEYSNKTYIICM
TNAHTPSGWAPVHVNIRSIGMAKLDNADFLYVDAWSSNFSWGGASPPEEGSLVVITKGQT
ILLDQNTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTHLAHTAKAGERTLILHEAVTWKPGD
EIVIASTGHRHSQQENEKRTIASVSAGGRNITLTNPLNYTHLGITVTLPDGTLFEARAEI
GILTRNILIRGSDNVEWNDKIPACPDGFDTGEFATQTCLQGRFGEEIGSDQFGGCIMFHA
PIPGANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSSVPEPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGEAIGAVIKNAKIVGHVDELGMGSAFCTMKGLVLPFSEGLTVSSVHFMN
FDRPSCAALGVTSITGVCNERCGGWSAKFIDIQYSHTTNKAGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCSQEAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKSVDHITNISYTSTFYGFKEQDYVI
ISHNFTQNADMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGKNDLHQSQSI
SGTLDPDVKDVVINFQAYCCVLQDCFPVHPPSRKPIPRKRPATYNLWSNDSFWQSSRENN
YTIPHPGANVVIPEGTWIVADTDIPPMERLVIWGVLELEDK-HNVGAAESSYRKVVLNAT
YILLQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWALPEGPNQGSKVLGVFGELDLHGIP
RSIYKTKLSETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTEIRSIVKILHDHKIL
ILNDTLSYTHFAGSYLVPETGQSYTLAADVGILNRNIKILGEDYPGWLKESFGARILVSS
FTANMVTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGKIQERGSSYIQGCAFH
SGFSPAIGVFGTDGLDIDDNVIHFTVGEGMR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRINGEPCSSQSYSLEKWFDNEAHGGLF
GIYMNQDGLPGCSLI-----QGFTIWACWDYGIYFQ----------------TTESVRIY
NVTLVDNGMAISSMIYTPPAVSHRISSKTVQIKNSLIVGSSPEFNCSDVLTNDDPNIELS
AAHRSSRPP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISGKCSTFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGKSGSVIPEAEYEWNGNSQFGIG
DYRIPNVMLTFPNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYRCFGMEYAMMVIESLDS
DAETRRLSPVAVVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALGKSYEVYFTG
TSPQNLRLMLLNVDHDKAVLVGIFFPTRQRLDVYVNNSLVCPQNTVWNSQKKHCELN--R
HVYTEQFLPNLNFTVLGENY-DRMYQMLYLLVKGTIPVEIHTTSVIYVSFQLA-VTEDDF
YSSHNLVRNLALFLKISSDKIRVSKVIRGESLR--RKRST-GLTVELEIGDSPPQFITSD
TTGQ--MLLS-ELQET--AASLGQAVILGKTSSILGFNISSMSITSPIPSPSDSDWIKVT
AQPVERFA--FPVHHVAFLSSLSVITQPVATQLGQPFSQQPSVKAVDSDGNGVSVGITSL
TLKSVLKDSSNNQISGPSGITTIPYSSCWANYTDL---SLLRTGKNFKIEFILDDVVQV-
----ESRTFSLAAQSVSSSGSS--S--------------------SSNSKVSTVGTAAQI
VTTVVSCLVGRVLLLEIFTTAVLILNILGSN-----------------------------
-------------

----------------------------MGH-LL--LR-----PGFWWL-------LLCA
AGPRT-----VGSKTIPKVTEVMPXXXXXXXXXXXXXXXXXFSHENHFNYGVDNAELGNS
VQLVSSFRSISCDVEKDASHSTHITCYTRAMPEGSYAVRVSVDGIPITENNTCRGHVNSR
ACSFSA-------RSFRTPTIRSITPFSGPPGTLLTIRGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLIPQSDTXXXXXXXXXXXXXXXXXXXXXXXXXXXXHHNVSFILD-S
DYGXXXXXXXX-XXXXXXXXX-X-----------------------XXXXX

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 439)

XXITSIFPS
KGSIQGGTILT-ISGRFFDQTDFPVEVLVGGQA----CGILNVTESSIWCKTPS-KPH-F
LKNVYPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXERIAYHSGNANSYFSSPTQRSN
DIYLQKGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXERWETTGATNEVQQLIVSSPCEDPDSCAHHQYRLIFNMEKT----VLLPANAPD
FTLQSALNDLWSIKPDTVQVMRT-QNSQSFIYTITFVSARXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFQVALEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFHQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XWTYTCIDLLDLIQTK
YTGTNFVLQRISLQKATESHSFYVDIVYIGQSATVATPGEMPKRRLPALANKGIVFKHFQ
VNQIKVNGSTMTNQYSVTMSSYDCSYNIPLMAVSFGQIVSNETENESAYRGNNWPGESKI
RIQRVQKASPPISGSFDIQAYGQILK-GLPAAVSAVDLQFALQRLQEMGQVLVTREGTCA
GYSWNVKWKSTCGRQNLLQINDSNIIGEKANM--TVTKIKDGGLFRQHVRGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFMWDSTAS

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1258)

PLISAISPSQGSYEEGTILTIVGSGFSPSS---
AVSVSAGPVACSLLSVA-E-NEIKCQILNGSAGYMPVAVSTADKGLAQSLGG-EAFH

ENSGT00780000121902_0_Linker_5_6 (1258, 1262)

FIY
R

PF01833 // ENSGT00780000121902_0_Domain_6 (1262, 1342)

SQISHIWPDSGSLA-GGTLLTLSGFGFNENSTVLVGNGTCSVNEGDRNRIICSTPKRIE
GTVDISVITNGYQATRKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YTCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1444)

PVITDFSPKLRTI-----LGEVNLTIKGYNFGN
ELKQKVEVYVGGKSCQILHRNLTDI-RCLLPPL-------PPGKHDIHVEVRNWGFAST-
RDK

ENSGT00780000121902_0_Linker_7_8 (1444, 1452)

LNASIEYI

PF01833 // ENSGT00780000121902_0_Domain_8 (1452, 1592)

LEVTNMFPQRGSVYGGTE-ITIMGFGFSTIPTENTVLLXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXHGSGYAWSPSVLNVSVGDTVTWRWQAQPFLKGIGY
RVFSVSSAGSVIYDGKGFTNGRQKSTSGSFS

ENSGT00780000121902_0_Linker_8_9 (1592, 1693)

YQFTSPGVHYYSSGYVDEAHSIFLQGVIN
VFPAETRHVPLHLFVGNTEATHTL----GGPKNLQWGSSATGCLAPQPLCDLNNTRVQTS
NRLLFELSSCLS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1782)

PSISNITPSTGTANELITITGHGFSNLTCANKA-SNGSHQFAVEENSD
NSIVCRIDPQTSMDVCSREIVALIVYNLGTAIITLPGESDR

ENSGT00780000121902_0_Linker_9_10 (1782, 1787)

HFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVVPMAGSTT
GKTRVTLRGSGFAASYAGVEVFMGHFPCKVLLVNYTAVECETSPAPQQLVHVDLLIHGVP
AQCQGKCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1959)

PSVTGIFPNAIN-GSAQVLIEGEGFGNFLEEIAVFIGNQQFRAT
EVTENNITVLVTPLPAGLHALSVVVGSKGLALGNLALR

ENSGT00780000121902_0_Linker_11_12 (1959, 1960)

S

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

TAVASVSPASGSVGGGTTLTI
AGNGFYPGNTTIIVGSELCQIISVNSSEVYCSTPPGTAGRVDVKIF-NTVTYPHQPFTYT
LQDTPFLKGIVPTR-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF01833 // ENSGT00780000121902_0_Domain_14 (2129, 2220)

XXXXXXXXXXX-SFGGGQTMTVTGTGLTPQNS
IVLVCGSECAVDRLSSNYTTLFCNIPPNNG-SGPEQACDVTV---VNGKDATQSRTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
SASLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLIDEIVPKRGGTAGGTRLSIKGSGFSENIQDVYISIGDALCDVEYSNKTHIICM
TA-RRPSGWAPVHVNIRSMGMARLDGADFLYVDAWSSNFSWGGEPPPEEGSLVVITKGQT
ILLDQSTPILKMVLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHRAIITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPIPVIWTRLAYTAQAGDQMLVLQEAVTWKAGD
DIVIASTGHRHSQRENEQRTIAAVSADGINITLTNPLNYTHLGVTVTLSDGTLEA-RAXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEFATQTCLQGKFGEEMGSDQFGGCIMFHS
PVPSADLVTGRIEYVEIHHAGQAFRLGRYPIHWHLLGDLHFKSYVRGCAIHQTYNRAITI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTALLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDQNICQKRVPLGEFFNNTVHSQGWFGIW
IFEEYFPMQTGSCTSTVPVPAIFDSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETHGAMIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTVSSVHFMN
FDRPNCVALGVTSITGVCNDRCGGWSAKFVDIWYSHTPNKAGFRWEHEVVLMDLDGSLTG
HTGYSVIPHSPLLDPSHCTQEAEWSIGFPGSVCDTSVSFHRLAFNKPAPASLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDVDHISNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSSPLSWNSSKNGDWHLEANTSTLYYLVSGRNDLHQNQPV
SATLEPDVKDVIINFQAYCCILQDCFPVHPPTRKPVPRERPATYXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXMWIVADTEMPPMERLTILGVLELEDK-YSVRGAESAHQKVVLNAT
YISVQGGRLIGGWD-NPFKGELHIVLRGNHSTPEWALPKGS-----SLGVFGELDLHGIP
RSIYKTKLSETAEAGSKVLSLMDAVDWQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXERHHIPGTGQSYTLAADVGILSRNIKIVGEDYPGWFKESFGAHVLVGS
FTEHAVTFTXXXX-XXXXXXXXXXXXXFRDSVDPRYALTFLNRGQIQEHGLSYVRGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQDRKD
LSSTLWHAAIEINQGTNTVLQNNVVAGFGRVGYRIDGEPCSGQANSMEKWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWACWDYGIYFQ----------------AMESVHIH
NVTLVDNGMAIFPMIYTPAAIAHKISSKTVQIQ---IVGSSPDFNCSDVLTNNDPNIELT
APHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGRLDISGKCLTFVGFKNVCSAETNVIFITNPLNEDLQHPIYVKNIQLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSLLRDMDGSFLGNCGSVIPQAEYEWNGNRQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCRFIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TTPQNLRLMLLNVDHNKAVLVGIFFSTLQRLDVFVNNTLVCPKNTIWSTQQKHCEPN--G
QLHTEQFLPSLDSTVLGENYFDRTYQMLYLLVKGTSPVEIRTTKVIFVSFQLPSVTVDDF
YNPHNLVQNLALFLKIPRDKIRVSKIIRGEGLR--KKRSL-GLPVEYEIGDPPAQFLNSD
TTGQ--MQLS-ELQEI--ANSLGQAVILGKTSSIFGFNISAMSITSPIPSPGDSRWSKXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX---XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKNYKIEFVLDSAVRV-
----ESGTFSIPAQTASSGSSSSS----------------------STSKASVVSPSVQI
LTILTGCLIQRLLLLEMASS--LLLNISIESN----------------------------
-------------

----------------------------MGH-LW--LSGT---WFLSGL-------LWCA
ADSHK-----GSSETI

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNTELGNH
VQLVSSFQSITCDVEKDSSHSTQITCYTRTMPEDTYSVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVAENNTCKGVASSW
ACSFST-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-RNV
RILRIYVGGMPCELLIPHSDDLYGLKLDHANGDTGSVTCKTTGTYIG--HHNVSFILD-S
DYGRSFPEKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 352)

YFVSSLNKI-SMFQTY-----------------------

PF01833 // ENSGT00780000121902_0_Domain_3 (352, 428)

PEVVMVSPS
KGSTEGGTILT-IHGQFFDQTDLPVRVLVG------------------------------
------G

ENSGT00780000121902_0_Linker_3_4 (428, 430)

GR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVAR
ISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTE--DKERIAYYSGNANTYFSNSTQRSD
EIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVVPE
VQVITLENWETADVTNEVQQVTVTSLCVGADSCSLSQYRFIYNMEKT----VWLPADASD
FMLKSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSI
TEQSKGKPNLETFTLNWDGIASKPLTPESTEAEFQVAVEEMVSAKCPPEIAHLEEGFLVK
YFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYN
QLCLAYKGSLANFIGLKFKYQDS-GKIIRSADVQLEYNFASGN-KWIYTCIDLLDFLQTK
YAGTSFSLQRITLQKSSEFQSIYVDAVYIGQTPTVSVLDEMPKRRPPALANKGIFLKHFQ
VNRTKLNGSAMTIQYSVTITSYNCSHNIPMIAVRFGQIITNETKNELVYRGNNWPGESKI
RIQKIQEASPPISGSFDVQAYGHILE-GIPAAVPAADLQFALQSLEEIEQVSVNREGTCA
GYSWSIRWTSPCGKQPLLQINDSNIIGEKANV--TVTTIKEGGLFRQRIPGDMLRTVNQQ
PQVEVYVNGIPAKCSGDCGFTWDAMIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLILTTTPSEGSYAESTILTIAGSGFSPTS---
AVSVSVGSTRCSLLSVE-E-NKIKCQILNGSAGHVPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNLEG-EGSYFVY
RS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGTLLTISGFGFSENSTVLVGNETCNMIKGDLNRITCRTSKRIE
GTVDISVITNGIQVTAKDSFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVVTDFSPKERTV-----LGKVNLTIKGYNFGN
ELAQNT-VYVGRKHCQVLYSNFTDI-TCLLPTL-------PPGKHDIYVKVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1457)

AST-
RNKLNASILYILEVIH

PF01833 // ENSGT00780000121902_0_Domain_8 (1457, 1510)

MFPQRGSLYGGTE-ITIMGFGFSTIPTENSVLLGSFPCDITSSS
ENVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGY
RIFSVSSPGSVTYDGKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVIN
VFPAETRHIPLHLFVGNMEATYVP-----GPAHLQLTSTAAGCLATEPLCALNDTRVKHS
NKLFFELSNCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1759)

PSIINITPSTGTANELITIIGHGFSSLPCANKV-TIGSYPCVVEESSE
NSIICHIDPQNSMNVGIR

ENSGT00780000121902_0_Linker_9_10 (1759, 1787)

EIVTLIVYNLGTAINTLTKAFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVMPKAGSTT
GMTRVTIQGSGFMASPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVP
AQCQSNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLENIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYVTGIFPNSIQ-GYGNVLIKGEGFGTVLEEISIFIGSQQFRVI
DVNENNITVLMAPLEVGLHSLSVVVGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TISS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIAGGTTLMI
TGNGFSPGNTTVTVGDKPCQITFISSSEVYCSTPAGRAGTANLKISANAIIYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKRIIPNR-GLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVG
EHAGGIFPVTMLHKTKGSAVSSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

SIQNIYPTKG-SFGGGQTLTVTGMGFDPWNS
TILVCDSECAVDKLGSNSTTLSCEIPPNNG-QGLDQVCGVNV---VNGKDSSHSMKLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2304)

PLITEVSPRRGSTAGGTRLTVTGSGFSENTQDVQVFVGNSKCDIQYSNKTHIVCM
TSAHAPSGWAPVHVNIKNIGLAK

ENSGT00780000121902_0_Linker_15_16 (2304, 2321)

LENADFLYADVWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGNPPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEASPFQHRAVITLH
GHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTLTVQEAVTWKAGD
NIVIASTGHRHSQAENEKRTIASVSADGMRITLTRPLSYTHLGITTTLPDGTVFEARAEV
GILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHA
PLPGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNNEAGIET
KRILAPYVGGWGESSGAVIKNAKIVGHLDELGMGPTFCTSKGLVLPFSQGLTVSSVHFMN
FDRHACVALGVTSITGVCNDRCGGWSAKFVGIRYFHAPNKAGFRWEHEAVLIDIDGSLTG
HTGHTVVPYSSLLDPSHCTQEPAWSIGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVVDMRNGSSNPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPI
SGTLDPGVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3308)

WQSSPENN
YTVPHPGANVIIPEGTWIVADVDIPPMERLIIWGVLEMEDK-SEIGMTGPTYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELHIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLP
RSVYKTK

ENSGT00780000121902_0_Linker_18_19 (3308, 3472)

LLEIAEAGSRILSLVDAVDWQEGEDIVITTTSYDLHQTEIRRIAKILHGHKIL
ILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDDYSVLSKDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFHHSGQEGYRDSTDPRYAVTFLNLGQIQDHGL

PF13229 // ENSGT00780000121902_0_Domain_19 (3472, 3661)

SYVRGCAFH
HVFSPAIGVFGTDGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANPMENWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVNNGMNIFSMIYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLHVSD--STFVGFKDVCSGETNVIFMTNPLNEDLQHPIHVKNVQLIDTIEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNSQLGIG
DYRIPKAMLTFLNGSRIPVAEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDS
DTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKKYEVYFTG
TSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKLCELE--R
HLNTEQFLPNLGSTVPGENYFDRTYQMLYLLLKGTTPVEVHSATVIFVSFQLPVMTADEF
FSSHNLVRNLALFLKIPSDKIRVSRIIG-ASLR--KKRST-GHIMEFEIGAAPTQFLSNS
TTGQ--MQLS-ELQEI--TDSLGQAVVLGKISTILGFNVSSMSITSPIPQPTDSGWIKVT
AQPVERSA--FPVHYLALVSLLSVVVQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSL
TLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDL---TPHRTGKNYKIEFVLDNTVRV-
----ESRPFSLSAQSVPGGSGSST-SSG--------------SSSSGHSKASSVGTPVQT
LAVVTACLVGRLLLLEIFMAAVFILNTTVGSN----------------------------
-------------

----------------------------MGH-LW--LLGT---WCLCGL-------LLCA
LELRS-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 169)

PKVAEVMPKYGSINGATRLTIKGEGFSQANQFNYGVDNTELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDGVPIA

ENSGT00780000121902_0_Linker_1_2 (169, 199)

ENNTCKGHINSW
ACSFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSLPERMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 427)

EITTISPS
QGSVRGGTTLT-ISGRFFDQTDFPAKVLVGGQA----CDILNVTENSILCKTPP-KPQ-I
LKTVYP

ENSGT00780000121902_0_Linker_3_4 (427, 443)

GGRGLKLEVWNNSRPV

PF07691 // ENSGT00780000121902_0_Domain_4 (443, 558)

HLEAILEYNEKTPGYMGASWVDSASYSWPMEQDTFVAR
FSGFLVAPESDVYIFYIKGDDHYALYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSD
GIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQYRNVYSEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSLYQYRLIYNMEKT----VLLPADASD
FLLQSALNDLWSIKPDAVQVTRA-QNPQSCIYTITFISARGDFDLLGYEVFEGNNVTLDI
TEQTKGKPSLETFTLNWDGIVSKPLTPQSSEAEFQVAVEEMVSTKCPPEIANFEEGFVVK
YFRDYETDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLKNYIGLKFKYQDN-GKVTRSTDKQFTYNFAHGN-NWTYTCIDLLDLIQTK
YTGTNFSLQRISLQKASESQSFYVDIVYIGQTSTISTLNGMPKRRLPALANKGIFLKHFQ
VNQTKTNGSTVTNQYSVTMTSYNCSYNIPMIAVSFGQIIAHKTENESVYRGSNWPGESKI
RIQRIQAASPPLSGSFDIQAYGHNLI-GLPAAVSAADLQFALQSLKEVGRVSVTREGTCA
GYSWNIQWRSTCGKQNLLQINDSNIIGEKANM--TVTKIKEGGLFRQHILGDLLRTPSQH
PQVEVYINEIPAKCSGDCAFTWDSRIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1247)

PSVLATSPHQGSYEESTILTIVGSGFSPSP---
AVSVSVGPIGCPLLSVD-E-NEIKCQILNGSAGRALIAVSVAGFGL

ENSGT00780000121902_0_Linker_5_6 (1247, 1263)

AQSVGV-ENFHFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

KISHIWPDSGSLA-GGTLLTLSGFGFNENSMVLVGNETCNVIEGDWNGITCRTPKRIE
GTVDISVITNGFQATAKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PVITDFSPKVQTI-----LEEVNLTIKGYNFGN
ELTQDMVVYVGGKTCQILHWNFTDI-RCLSPKL-------SPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1511)

EVTNMFPQRGSLYGGTE-ITVMGFGFSPIPTENTVLLGSFPCNVISSS
EKVIKCTLQS

ENSGT00780000121902_0_Linker_8_9 (1511, 1693)

TGNVFRITNNGEDSVHGLGYAWSPSVLNISVGDTVTWHWQTHPFLRGIGY
RVFSVSTPGSVIYDGKGFMNGRQKSKSGSFSYQFTSPGIHYYSSGYVDEANSIFLQGVIN
VLPAESRHIPLHLFVGSTEATYAQ----GGPEILHLGSSVAGCLATEPVCGLNNTGVKNS
KRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PSISNITPSTGTVNELITITGHGFSNLTCANKV-TIGGYPCVVEESND
SSIMCHIDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVTVTVYNFGTAINILSNEFYRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPNAGSTT
GMTRVTIKGSGFAVSSAGVEVLMGHLPCKVLSVNYTAIECETSPAPQHLVIVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITRVFPDSIQ-GSERVLIEGEGFGTDLEEITVFIGNQQFRAI
DVNESNITILVPPLPAGLHSIIVVVGTKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIGGGTVLVI
TGNGFYPGNTTVTIGDDPCQIISVNSSEIYCHTPAGTAGMVSVKILVNAIAYPPLPFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPSR-GPPGTIIEITGSNFGVEILEISVMINNIQCNVTMVNDSVLQCLTG
DHAGGIFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNIHPSQG-SFGGGQILTVTGTGFNPQNS
IILVCGSECAIDRLRSDYRTLLCEIPPNHG-RGPEQACEVSV---VNGNDMSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MESLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PFITAVSPKSGSTAGGTRLTVVGSRFSENMEDVNITIAEAKCDVEYSNKTHIICM
TNAHTPSGWALVHVHIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

SIGMAQLDNADFLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGLPVPVIWTHLAHTAKAGERTLILQEAVTWKAGD
NIVIASTGHRHSQRENEKRTIASVSVDGINITLTNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPPCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGTNMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEYGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPEPAVFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNNEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSAGLTVSSVHFMN
FDRPNCAALGVTSITGVCNERCGGWSAKFVDIQYFDTPNKAGFRWEHEVMLIDIDGSLTG
YKGHTVIPHSSLLDPSHCTQEAEWSIGFAGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKDMDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSLNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPT
SGTLDPNVKDVTINFQAYCCILQDCFPVDPSLRKPIPRKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPRPGANVVIPEGTWIVADTDMPPMERLIIWGVLELEDN-YNVGAPESSYRKVVLNAT
YISLQGGRLIGGWEDDPFKGELKIVLRGNHSTPEWALPEGPNQGAKVLGVFGELDLHGIP
HSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3471)

SETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDSHQTETRSIVKILHNHKIL
ILNDSLSYTHLAERYHVPETGQSYTLAADVGILTRNIKIVGEDYPGWAEDSFGARVLVGS
FSENMITFKGSAR-ISNVEFYHSGQEGFRDSIDPRYAVTFLNLGQIQEHG

PF13229 // ENSGT00780000121902_0_Domain_19 (3471, 3663)

ASYIRGCAFH
YSFSPAIGVFGTDGLDIDDNIVYFTVGEGMR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQKNIVAGFGRAGYRIDGEPCSSQSNPTEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYTPAAISHKIASKKVQIKSSLIVGSSPEFNCSDVLTDNDPNIELT
VAHRSPRPP--------------------T--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAICGLLDVSG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLIDTTEQSK
IFIHRPDISKANPSDCVDMVCDAKRKSFLRDLDGSFLGNPGSVIPQAEYEWNGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYECFGMEYAMMVIESLDS
DTETRRLSPVAVVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHNKAVVVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQQKYCELN--K
HLYTEQFLPNLDSTVLGENYFDRTYQMLYLLVKGTIPVEIHTATVIFVAFQLPTVTEDDF
YSSHNLVRNLALFLKIPSDKIRISKIVRGKSLR--RKRST-GVTIELEIGDPPTQFLSND
TTGS--LQLP-ELQEI--ASSLGQAVILGKTGNILGFNISSMSITNPLPSPGDSGWIKVT
AQPVERSA--FPVHHVAFVSSLLVITQPVAAQPGQPFSQQPSVKAVDSEGNCVSVGVTML
TLKAILKDSNNNQVSGLTGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVRV-
----ESRTFNLPAQSVSSSSSS----------------------SSSNSKATTVGTSAQI
MSTVISCLIGKMLLLEIFMAAVFVLNVTIGCN----------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ANPRA-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGADNTELGNS
VQLVSSFQSIACDVEKDASHSTHITCYTRAMPEGSYTVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIVRSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTFIG--HHNVSFILD-S
DYGRSLPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLSKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTAIFPS
RGSIQGGTMLT-ISGRFFDQTDFPVRVLVGGET----CDTLNVTENSISCKTPP-KPH-I
LKTVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 442)

GLKLEVWNNSRP

PF07691 // ENSGT00780000121902_0_Domain_4 (442, 558)

VHLEEILEYNEKTPGYMEASWVDSPSYIWPMEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPAQRSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1170)

EYRLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKITSPCVEANSCSLYQYRLIYNMEKT----VFLPADASE
FILQSSLNDLWSIKPDTVQVIRT-QNTQSYIYTITFISTRGDFDLLGYEVFEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQRAVEEMVSTKCPPQITNFEEGFVVK
YFRDYETDFNLDRINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDT-SKIIRSTDVQFTYNFAYGN-NWTYTCIDLLDLIRTK
YTGTNISLQRISLQKASESQSFYVDVMYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNRTKINGPTMTYQYFVTMTSYNCSYNIPMMAVSFGQIITHETENEIVCRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGRILK-GLPAGVSAADLQFALQSLEGMGRVSVTREGTCA
GYTWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRQHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWDSAITPL

PF01833 // ENSGT00780000121902_0_Domain_5 (1170, 1243)

VLGTSPSQGSYEEGTILTIVGSGFSPSS---
AVTVSVGAGGCYLLSVD-E-KEIKCQILKGSAGHAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EEFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVFVGNETCDVIEGDLNRITCRTPKKTE
GTVDISVTTNGFQATARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1435)

PIITDFSPKVRTI-----LGEVNLTVNGYNFGN
ELTQNMVVYVGGKTCQILHWNFTDI-RCLLPKL-------PPGKHDIYVEVRNW

ENSGT00780000121902_0_Linker_7_8 (1435, 1453)

GFAST-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1509)

EVTSMFPQRGSLFGGTE-ITIRGFGFSTIPAENTVLLGSIPCNVTSSS
ENVIKCIL

ENSGT00780000121902_0_Linker_8_9 (1509, 1693)

HSTGNIFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVTWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGFVDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GGPENLHLGSSVAGCLATEPLCGLNNTRVKNS
ERLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSISNITPSSGTVNELITIIGHGFSNLPCANKI-TIGSYPCVIEESND
DSITCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNVGSTT
GMTRVTIKGSGFAVSSAGVEVLMGHFPCKVLSVNYTAIECDTSPAVQQLVDVYLLIHGVP
AHCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PYITGISPNSII-ESVKVIIEGEGFGTVLDDIAVYIGNQQFRAI
DVNENNITAVVTSLPVGRHSLSVVVRSKGLALG

ENSGT00780000121902_0_Linker_11_12 (1954, 1962)

NLSVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASVSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIIFVNPNKVYCHTPPGTAGMVGVKIFVNTISYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIVPSR-GPPGTEIEITGSNFGIEILDISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
VILVCGSECAVDRLRSDYTTLLCEIPSNNG-RGAEQACEVSV---INGKDLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVFLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPKRGSTAGGTRLTVMGSGFSENIEDVHITIAEAKCAVECSNKTHIICM
TNAHPLSGWAPVHVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYVDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGRSPPEEGSLVVISKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTRLAHTAKAGERILILQEAVTWKPGD
NIVIASTGHRHSQGENEKRIIASVSADGVTITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNKKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHTGQAFRLGRYPIHWHLLGDLHFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIRGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPARFNSFTAWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLDELGMGSAFCTRKGLVLPFSEGLTVSCVHFMN
FDHPNCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNANHINWYFKGVDHITNISYTSTFYGFKDEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSRNGDWHLEANTSTLYYLVSGRNDLQESQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPMPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPEGIWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTRDWALPEGPNQGSKMLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSKILSLMDAVDWQEGEEVVITTTSYDFHQTETRSIVKILHDRKIL
ILNDSLSYTHFAEKYHVPGTGESYTLAADVGILSRNIKIVSEDYPGWSQDSFGAHVLVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIQGCAFH
HGFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGN-ANRVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINGGTNTVLQNNVVAGFARAGYRIDGEPCPSQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFIIWTCWDYGIYFQ----------------TTENVYIY
NVTLVDNGMAIFPMIYLPAAISHKISNKKVQIKSSLIVGSSPGFNCSDILTNDDPNVELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPQKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDIDGSFLGNAGFVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFLNGSKIPVTEKAPYKGIIRDSTCKYIPQWQSYQCFGMEYALMVIESLDP
DTETRRISPVAIMGNGYVDLLN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEIYFTG
TSPQNLRLMLLNVDRNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQRHCELN--T
LLYKDQFLPNLDSTVLGENYFDRTYQMLYLLVKGTIPVEIHTATVIFVSFQLPAVTEDDF
YTSHNLVRNLALFLKIPSDKIRVSKMTRQKSLR--RKRSI-GFIIEIEIGDPPIQFLNNG
TTGQ--MQFS-ELQET--AGSLGQAVILGKISSILGFNISSISITNPLPSPSDSGWIKVT
AQPVERSA--FPVHHVAFVSSLSVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDSNNNQVSGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFLLDNVVRV-
----ESRTFSLQAESVSSSS-------------------SSSGSSSSNSKASTVGTSAQI
MTVVISCLIGRMWLLEIFMAAVSTVNITLRSY----------------------------
-------------

------------------MLPVSHATKSSQR-QW--YLA---------------------
-GTSF-----CGSKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 165)

PKVTEIIPKYGSINGATRLTIKGEGFAQANQFNYGVDNAELGNS
VQLVSSFQSFSCDVEKDSSHSTQITCYTRAMPEGSYTVRVSVDG

ENSGT00780000121902_0_Linker_1_2 (165, 199)

VPVTESNTCRGRLDSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIKSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMICKTTGTYIG--HHNVSFILD-S
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 422)

EVTMISPS
RGSIQGGTMLT-ISGRFFDQTDFPVRVLVGGQA----CDILNVTENSICCKTPP-KPD-V
L

ENSGT00780000121902_0_Linker_3_4 (422, 430)

RTVYPGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 559)

GLKLELWNNSRPVHLEEILEYNEKTPGYMGASWVDSASYIWPMEQDTFVAR
FSGFLVAPESDVYRFYIKGDDRYAIYFSQTGHPKD--KVKIAYHSSNANNYFSSPTQSSD
DIHLQKGKEYYIEILLQE

ENSGT00780000121902_0_Linker_4_5 (559, 1168)

YRLSAFVDVGLYQYRNVYTEQQTEDAVNEEQVIRSQSTIVQE
IQVITLENWERTTARSEVQKITVTSPCVEANSCSHYHYRLIYNMEKT----VLVPGDASD
FILQSALNDLWSIKPDTVQVIRT-QNSQSYVYMVTFISTRGDFDLLGYEMIEGNNVTLDI
SEQIKGKPSLDTFTLNWDGITSKPLTPWSSEAEFQAAVEEMVTAKCPPQIANFEEGFVVK
YFRDYESDFNLEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIALKFQYQDR-SKITRSNDIQFTYNFTNGN-NWTYTCIDLLDLIQAK
YTGTNFSLQRIGLQKASESQVFYVDTVYIGQTSTVSAWDEMPKRRLPALANKGIFLKNFQ
VNQTKINGSSITNQYSVTMTSYNCSYNIPMMAVSFAQIITNETENESVYRGNNWPGESKI
RIQRIQAASPPVSGSFDIQAYGHILK-GLPATVSAADLQFALQSVEEVGRVSVTREGTCA
GYSWNIQWRSTHGRQNLLQINDSNIIGEKANM--TVTKIKDGGLFRRRILGDLLRTPNQQ
PQVEVYVNGGPAKCSGDCGFTWDFMVT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PVVRAINPSQGSFEESTILTIVGSGFSPSS---
AVLVSVGPVGCSLLSV--DENEIKCRILNGSAGHFPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1264)

DVGLARNIEG-EVLYFIY
QNQ

PF01833 // ENSGT00780000121902_0_Domain_6 (1264, 1342)

ISHIWPASGSLA-GGTLLTLSGFGFNENSKVLVGNETCNVIEGDLNKITCRTPKRTE
GTVDISVITNGFQASAKDAYS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1440)

PVITDFSPKVRTI-----LGEVNLTVKGYNFGN
ELAQNVEVYVGGRPCQIFHWNFTDI-RCLLPKL-------SPGKHAIYVEVRNWGFAST

ENSGT00780000121902_0_Linker_7_8 (1440, 1453)

R
YNKLNASIQYIL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTTMFPQRGSLYGGTE-VTIMGVGFSTIPTENTVLLGSFHCSVISSS
ENVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNTFRITNSGEDSVHGLGYAWSPSVLNVSVGDTVTWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFMNGREKSASGSFSYQFTSPGIHYYSSGYVDESRSIFLQGVIN
VLPAETRHIPLHLFVGSTEATYA-----PGPVSLHLGSSGTDCLATEPQCGLNNTGVKNS
DRLVFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1759)

PSISNISPSAGTLHELITITGCGFSNLTCANKV-TIGSYPCIVEESSD
NSIICHIDPQNSMDVGIR

ENSGT00780000121902_0_Linker_9_10 (1759, 1787)

EIVTLTVYNLGTALNTLSSESDGRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDMVLPNAGSTS
GMTRVTIKGSGFAVSSAGAEVFMGHLPCKVLSVNYTAIECETSPAPQQLVKVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1878)

YSESITA

PF01833 // ENSGT00780000121902_0_Domain_11 (1878, 1953)

FITRILPNSIK-GPGEVLIEGDGFGTALEDIAVFIGNQQVRAI
DVNDNNITVLVSPLPAGIHPLSVVVGSKGVAL

ENSGT00780000121902_0_Linker_11_12 (1953, 1960)

GNLTVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVTPTSGSIAGGTPLVI
TGNGFYPGNTTVTVGDEPCEIISVNSSEVFCSTPAGMVGRVDVKISVNTVAYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YT
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PLLREIDPRT-GPPGTQIQITGSNFGIDILEISVMINNIQCNVTMVNDSVLQCIIG
DHAGGTYPVMMHHKTKGFAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

TIQNIHPSQG-SFGGGQTMTVTGTGFNPQTS
TILVCGSECAVDRLKSDCTTLLCKTPHNNG-RGPEQACEVSV---VNGKDLSQSTTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AMSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLITELSPKRGSTAGGTRLTITGSGFSENMQDVHITIAEAKCDVEYSNKTYIICV
TNAHTPSGWAPVNVHIR

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

SNGMAKLDDADFLYVDSWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLVVITKGQT
ILLDQNTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFQHRAVITLH
GHLRSPELPVYGTKTLAVREGILDLHGLPVSVIWTRLAHTAKAGERTLILQEAVTWKPGD
KIVIASTGHRHGQRENEKRTIASVSADGTNVVLTDPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDTMEWNHKIPACPDGFDTGEFATQTCFQGKFGEEIGSDQFGGCIMFHA
PVPGASMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFTSYVRGCAIHQAYNRAVTI
HNTHHLLVEWNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNNHPDGPSYDRNVCQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCEKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTRKGLVLPFSEGLTVSSVHFMN
FDRPNCAALGVTSITGVCNEKCGGWSAKFVDIQYFHTPNKAGFRWEHEVVLIDVDGSLTG
HRGHTVIPYSSLLDPSHCTQEAEWSIGFPGAVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNAKHINWYFKDVGHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVLDMRNGSSNPLSWNASKNGDWHLEANTSTLYYLVSGRNELQQSQPI
SGTLDPDVKDVIINFQAYCCILQDCFPVHPQSRKPNPRKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTIPHPGANVVIPEGTWIVADTDIPPMESLIIWGVLELEDK-HRVGAAESSYRKVVLNAT
YILLQGGRLIGGWEDNPFKGELQIVLRGNHSTPDWALPEGPNQGSKVLGVFGELDLHGFP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3468)

SETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIIKVLHDQKIL
ILNDTLSYTHLAERYHVPGTGQSYTLAADVGILSRNIKIFGEDYPGWFKESFGARVLVSS
FTENMMTFKGNAR-ISNVEFYHCGQEGFRDSTDPRYAVTFLNLEQIQ

PF13229 // ENSGT00780000121902_0_Domain_19 (3468, 3663)

NHGSSYIRGCAFH
NGFSPAIGVFGTDGVDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVALSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQSNPMEKWFDNEVHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESMHIY
NVTLVDNGMAIFSMIYTPAAVSHKISSKTVQIKSSLIVGSSPGFNCSDVLTNDDPNIELS
AAHRSTRPP--------------------S--ELPVQ------------------GG---
-KIIFFFIYVLG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIQLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWNGNSQFGIG
DYRIPKVMLTFPNGSRIPVTEKAPYKGIIRDSTCKYIPRWQGYRCYGMEYAMMVIESLDS
DTETRRLSPVAVVSNGYVDLING--PQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TSPQNLRLMLLNVDHKKAVMVGIFFHTLQRLDVYVNNTLVCPQNTIWNPKKKHCELK--R
HLYTEQFLPNLNSTVLGENYFDRTYQMLYLLVKGTIPVEIHTTAVIFVSFQLPAVTEDDF
YSSHNLVRNLALFLKIPSDKIRVSKIIQGKSLR--RKRST-ELTVELEIGDAPPQFINND
TTGQ--MQLS-ELQKI--VGSLGQAVISGKTSSILGFNISSMSITNPIPSPSDSAWIKVT
AQPVERFA--FPVHHVAFVSSLSVITQPVAAQPGQPFSQQPAVKAVDSDGDCVSVGITSL
TLKAILKDSNNNHITGLSGNTTIPFSSCWANYTDL---TLLRTGKNYKIEFILDDIARV-
----ESGTLSLPAQSVASGGGTNGGSSSS------------GSSDSSSSKASTVGTAAQT
VIVVISCLVGRVLLLETFMATVLILNINLGKHSSFLM-----------------------
-------------

----------------------------MGH-LW--LPGL---WGLWGL-------LLSA
AGPPT-----DGAKII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 170)

PRVTEVIPKYGSVNGATRLTIKGEGFSQANQFNYGADNAELGNS
VQLVSSFRSITCDVEKDSSHSTQITCYTRAMPEDSYAIRVSVDGIPIAE

ENSGT00780000121902_0_Linker_1_2 (170, 199)

NNTCKGQINSW
ACSFNA-------KRFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PVIRSITPLSGTPGTLITIQGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPQSDDLYGLKLDHTNGDMGSMICKVTGTYIG--HHNVSFILD-S
DYGRSLPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 434)

EVTMISPS
KGSVQGGTTLT-IHGRFFDQTDLPARVLIGGQP----CDILNVTENTVSCKTPP-RPH-I
LKTVYPGGRGLKL

ENSGT00780000121902_0_Linker_3_4 (434, 452)

EVWNSSRPAQLEEIHGFS

PF07691 // ENSGT00780000121902_0_Domain_4 (452, 558)

ENTPGYMGATWVDSTSYIWPMEHDTFVAR
FSGFLVAPDSDVYRFHIRGDDRYAIYFSQTGLPE--DKVKIAYHSTNANSYFSSPTQTSD
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYRLSAFVDVGLYQHRSVYTEQQTGDAINEEQVIKSQSTVIQE
VQVITLENWETSIATNEVQKVTVSSPCAGANSCSHYRYRLIYNMEKT----VLLPADASE
VTLQSALNNLWSIKPDTVQVIRT-QTLQSYVYTVTFISNRGDFDLLGYEVSEGNNVTVDV
AEQTKGKPSLETFTLNWDGILSKPLTPWSSEAEFQVAMEEMVSAKCPPQIAHFEEGFVVK
YFRDYETDFDLENVNRGQKTAESDAYCGRYSLKNPSVLFDSADVKPNRLPYGDILLFPYN
QLCLAYKGFLANYIGLKYQYQDS-GKITRSTDRQFTYNFAQGA-SWTYTCLDLLDLIQSK
QTGTNFSLQRISLQKASETQSFHVDVVYIGQVPTTSKLDEMTKRRLPALASKGIFLKDFQ
VNETKRDESTMTIQYSVTMTSYNCSYNIPTMAVSFGQIIASETENESVYRGNNWPGESKI
RIQRIQEASPPISGSFDIQAYGHILK-GIPATASAADLQFALQSLEEMGQVSVTRDGTCA
GYSWSITWRSACGKQNLLQINDSNVTGEKAKM--TVTKIKEGGLFRQRILGDLLRTPHQQ
PQVEVSINGIPAKCAGDCSFTWDPRAT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PKILAISPSQGSYEESTILTIAGSGFSPSS---
AVSVSIGSTDCSLLSVE-E-HEIKCQLLSGSAGRLPVEVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNIDS-EGFHFIY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGALLTLSGFGFSENSKVLVGNETCSVIEGNLNRITCRTPKRNE
GTVDISVITNGFQATTRNAFR

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1436)

PVITDFSPKIRTI-----LGDVNLTLKGYNFGN
ELTQNVVVYVGGKICQILHWNFTDI-RCLLPLM-------SPGKHSVCVEVRNWG

ENSGT00780000121902_0_Linker_7_8 (1436, 1453)

FAST-
SDKLNASIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1511)

EVTGMFPHRGSLYGGTE-VVIMGFGFSRIPTENTVLFGSFPCNVTSSS
ENAIRCTLPS

ENSGT00780000121902_0_Linker_8_9 (1511, 1693)

TGNVFRITNSGDDLVHGLGYAWSPSVLNVSVGDTVIWYWHAHPFLRGIGY
RVFSVASPGSVDYDGKGFTNGRQKSLSGSFSYQFTSPGVHYYSSGYVDEAHSISLQGVIN
VLPAETRHLPLRLFVGNIEATYAR----GGPETLPSGSSVSGCLATELLCGLNDTRVKDS
DIFLFELSSCIS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1759)

PSISNIAPSAGTVNELVTITGRGFSNLTCANKV-TIGRYPCVVEESSA
NSIVCHIDPQNSMEVGVR

ENSGT00780000121902_0_Linker_9_10 (1759, 1787)

EFVTLAVYNLGTAINTLPGEFDRRFALL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDTVWPNTGATT
GMTRVTLKGSGFAASLEGVEVFMSHFPCKVLAVNYTAIECETSPAPQQLANVHLRIRGVP
ALCQGSCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YSDSIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYVAGIFPNTVR-GPAEVLIEGEGFGTVLEEIAVFIGNQQFRAI
GVNENNITVLLSSLPAGLHDLRVVVRNKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1960)

TVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PMVASVSPTSGSLGGGTTLVI
TGNGFLLDNTTVTVGEGPCQIMFANSSEVHCRTPAGRAGKVNLQILVNALPYPPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIAPNT-GPPGTEIEITGSNFGVDISEISVMISDTGCNVTMVNDSALRCVVG
DHAGGTLPVVLHHKTKGSAVSSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

HIQNIHPQQG-SFGGGQILTVTGTGFNPQDS
VILICSSECAIDRLRSDYTTLLCEIPPSDG-VGPDQACEVNV---VNGKDSSPSTTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
TMALT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2311)

PLVTEISPTRGSTAGGTRLTVLGSGFSENPQDVHITIAEAKCDVEYSNRTHIICV
TSAHAPSGWAPLRVSIRDIGLAKLENTDFL

ENSGT00780000121902_0_Linker_15_16 (2311, 2321)

YIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKSPPEEGSLAVITKGQI
LLLDQSTPILKILLIQGGTLIFDEADIELQAENILITDGGILQIGTEASPFRHKAVITLH
GHPRSPELPVYGAKTLAVREGTLELHGLPVPVVWTRLAQTARAGERTLTLQDAVTWKAGD
SIVIASTGHRHSQRENEKRTIASVSADGVKITLTQPLNYTHLGITVTLPDGTVFEARAEV
GVLTRNIVIRGSENVEWNNKIPACPNGFDTGEFATQTCLQGKFGEEVGSDQFGGCIMFHA
PLPGANMVTGRIEYVEVSHAGQAFRLGRYPIHWHLLGDLQFNSYVRGCAIHQSYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVRQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMETGSCTSTVPLPAVFDSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEVGIET
KRILAPYVGGWGETNGAMIKNAKIVGHLDDLGMGSVFCTSKGLVLPFSEGLMVSSVQFMN
FDRPNCAALGVTSITGVCHDKCGGWSAKFIDIQYFHTPNKAGFRWEHEAVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAQWSIEFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHTSGWMALIPNANHINWYFRDVDHITNISYTSTFYGFKEEDYVI
ISHNFTQSPDMFSVIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRSDLHQSQSI
SGTLDPDVKDVVINFQAYCCILQDCFPVHPSSRKPIPRKRPATYTLWSNHSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSQENN
YTVPHPGARVVIPEGTWIVADTDLPPMERLIIWGVLELEDK-PRVEAPGPSYRRVVLNAT
YISVQGGRLIGGWEDNPFKGELRIVLRGNHSTPEWALPEGPNQGAKVLGVFGELDLHGLP
RLIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETAEAGSKVLSLMDAVDWQEGEEIVITTTSYDLHQTETRSIVKILHGHKIL
ILNDSLSYNHLAKRYYVPETGQSYVLAADVGLLSRNIKIVGEDYPGWSRDSFGARILVGS
FTGNTMTFKGSTR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQER

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYVRGCAFH
HSFSPAIGVFGTDGVDIDDNIIHFTVGEGIR-IWGD-ANRVRRNLVALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSSQSNPVESWFDNEAHGGLY
GIYVNEDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTEPVHIY
NVTLVDNGMAIFSMIYMPAAVAHKISSKTVKVESSLIVGSSPEFNCSDVLSSDDPNIELT
GAHRSAR----------------------PPAGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGRLDVSG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIYVKNIQLVDTTESSK
IYIHRPDISKVNPSDCVDMVCDAKRKSFLKDMDGSFLGSSGSVIPQAEYEWNGNRQLGIG
DYRIPEVMLTFLNGSRIPVTEKAPYKGIIRDATCKYIPEWQSYQCFGMEYAMMVIESLDS
DTETRRLSPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKSYEVYFTG
TTPQNLRLMLLNVDHNKAVLVGIFYSTLQRLDVYVNNSLVCPKNTIWNTQRKHCELK--R
NLYAEQFLPKLNSIIPGENYFDRTYQMLYLLVKGAAPVEIHTTTVIFISFQLPAVTEDDF
YSSHNLVRNLALLLNIPSDKIRVSQIIPGKSLR--RKRST-GHSIELEIGEPPIHFLSND
TTGQ--MKLS-ELQEI--SGSLGQAVILGKISSVLGFNISSMSITNPIPSPNDSGWIKVT
AQPVARSA--FPVHYVALVSSLSVVTQPVAAQPGQPFSQQPSIKAVDHEGNCVSVGITPL
TLKAVLKDSNNNQISGLSGNTTIPFSSCWANYTDL---TPLRTGKNYKLEFLLENVVRA-
----ESRTFSLPVQSVSGGGGSSASSSN-------------GGGSSSHSKASAVGTSAQI
TAVLISCLMGRALLLEIFLASAFIQNISVGSN----------------------------
-------------

----------------------------MGH-LW--LMGT---WSLWGL-------LLCA
VDPRA-----DGSEII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 165)

PKVTEIIPKYGSINGATRLTIKGEGFSQANQFNYGVDNAELGNT
VQLVSSFRSITCDVEKDASHSTQITCYTRAMPEDSYTVRVSVDG

ENSGT00780000121902_0_Linker_1_2 (165, 199)

VPIAENNTCKGHINSW
ACSFNA-------KHFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIKGRIFTDVYGSNTALSSNG-KNV
RILRVYIGGMPCELLVPQSDNLYGLKLDHPHGDTGSMICRATGTYVG--HHNVSFILD-S
DYGRSFPQKMT-

ENSGT00780000121902_0_Linker_2_3 (313, 354)

YFVSSLNTI-SMFQTY-----------------------AE

PF01833 // ENSGT00780000121902_0_Domain_3 (354, 423)

VTMVSPS
QGSIRGGTTLT-IRGRFFDQTDFPAKVLVGGQA----CDILNVTGNSICCKTPP-KPH-T
LK

ENSGT00780000121902_0_Linker_3_4 (423, 429)

SVYPGG

PF07691 // ENSGT00780000121902_0_Domain_4 (429, 557)

RGLKLEVWNNSRPVNLEEILDYNEKTPGYTGARWVDSASYSWPMEEDTFVAR
FSGFLVVPDSDVYIFYIKGDDRYALYFSHTGLPE--DKVRIAHHSTNANSYFVSPTQRSD
AIHLQKGKEYYIEILL

ENSGT00780000121902_0_Linker_4_5 (557, 1168)

QEYRLSAFVDVGLYQYRSVYTERQTGDAVNEEQVIKSQSTTIQE
VQVITLENWETSNAINEVQKIEVTSPCVEANSCSFYQYRLIYHLEKT----GLLPADASD
FLLQSALNDLWSIKPDTVRVTRT-RNSQSYIYTVTFLSSRGDFDLLGYEVLEGNNITLDI
TEQTKGKPSLETFTLNWDGVASRPLTPGSSEAEFQVAVEEMVSAKCPPEIANFEEGFAVK
YFRDYETDFHLEHVNRGQRTAETDAYCGRYSLKNPAVLFDSADVRPNRLPYGDILLFPYN
QLCLAYKGFLTNYIGLKFKYQDK-GKIPRSSDIQLTYNFAHGN-NWTYTCIDLLALIQTK
YTGTNFSLQRISLQKASESQSFYVDIVYIGQTPTISTLAEMPKRRLPALANKGIFLKHFQ
VNQTKTIGSTMTNQYSVTMASYNCGYNIPMIAVSFGQIITQETENESVYRGNNWPGEAQI
RIQRIQAASPPLRGSFDIQAYGHILK-GLPAAVSAVDLQFALQSLEEMGRVSVTRDGTCA
GYSWSIQWRSTCGRQNLLQVNDSNIIGEKANM--TVTKVKEGGLFRQRILGDLLRTPSQQ
PQVEVYINGIPAKCSGDCGFTWESMIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1260)

PLVLATSPSQGSYEESTILTIEGSGFSPNS---
AVSVSVGPVDCPLLSVD-A-NKLKCQILKGSAGRVPVVVSVADVGLAQNGEA-ENFHFT

ENSGT00780000121902_0_Linker_5_6 (1260, 1263)

Y
KS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

EISRLQPDSGSLA-GGTLLTLSGFGFNKNSMVLVGNETCNVIEGDLHRITCRTPRRTE
GTVDISVITNGFQATAKDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PVITDFSPKIRTI-----LGEVNLTIKGYNFGN
ELTPDMVVYVGGKTCQILHWNFTDI-RCLLPKL-------PPGKHAIYVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFAST-
RDKLSASIRYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1511)

EVTSMSPQRGSLYGGTE-ITVMGFGFSTIPAENTVLLGSFPCNVTTSS
EKVIKCILQS

ENSGT00780000121902_0_Linker_8_9 (1511, 1693)

TGNVFRITNNGEDSVHGLGYAWSPSVINVSVGDTVTWHWKTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRKKSTSGSFSYQFTSPGIHYYSSGYVDEANSIFLQGVVN
VLPAESRPVPLYLFVGSTEATYAQ----AEPENLYLGSSVASCLATEPLCGQNNTEVKNS
SRLLFELSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1757)

PLISNITPSTGTVHELITITGRGFSNLTCANKV-TIGSYPCIVEESSD
NSIICHVDPQNSMDVG

ENSGT00780000121902_0_Linker_9_10 (1757, 1787)

IREIVALTVYNLGTAINILSDEFYRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PHIDVVLPNAGSTT
GMTRVTITGSGFAVSSAGVEVLMGRFPCRVLSVNYTAIECETSPAPQHLVVVDLLIHGVP
AQCPGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1948)

PYITGIFPDTIK-GSAKVLIEGEGFGTDLEEISVFVGNRQFRAI
DVHEHNISVFLTPLPAGLHSVRVVVGT

ENSGT00780000121902_0_Linker_11_12 (1948, 1960)

KGVALGNLTLSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIGGGTTLII
TGNGFDPGSTTVAIGDDLCQITSVNSSAIYCRTPAGTAGMVAVKIFVDAVAYSPLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLNGIVPSR-GPPGTKIEIAGSNFGTEISDIAVMINNTPCNVTMVNHSVLQCVVG
DHAGGTFPVTLHHKTKGSAVSTAVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNIHPSQG-SFGGGHTMTVTGTGFNPQDS
VILVCGSECSLDRLRSDYTTLFCEIPPNNG-RGPELACEVSV---ANGKDLSRSTAPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2296)

PLITAVSPKRGSTAGGTRLTVVGSGFSENMEAVNITIAAAKCDVEYSNKTHIICL
TSAHTP-GWAPVHVH

ENSGT00780000121902_0_Linker_15_16 (2296, 2320)

IRISHVLFQDNADFLYVDVWSSNF

PF10162 // ENSGT00780000121902_0_Domain_16 (2320, 2438)

SWGGKSPPEEGSLVVITKGQT
ILLDQSTPVLKMLLIQGGTLIFDEVDIELQAENILITDGGILQIGTEASPFQHKAVITLH
GHLRSPELPVYGAKTLAVRDGTLDLHGLPIPVIWTRLAHTAKVGERTLILQEAVTWKPGD
YIVIASTGHRQSQRENEKSAIASISADGINITLTNPLNYTHLGITVTLPDGTLFDARAEV
GVLTRNILIRGSDNVEWNNKIPPCPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEIFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQTYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAIFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNAAAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGEFFNNTVHSQGWFGLW
IFEEYFPMQTGSCTSTVPVPAVFDSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYIGGWGEANGAMIKNAKIVGHLDELDMGSDFCTTKGLVLPFSAGLTVSSVNFMN
FDRPNCAALGVTSITGVCHDRCGGWSAKFVDIQYFHTPNKAGFRWEHEVVLIDTDGSLTG
YKGHTVIPHSSLLDPSRCTQEAEWSVGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSVVPFQKKRLTHTSGWMALIPSANHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGKNDLPESQPP
SGTLDPHMKDVTINFQAYCCILQDCFPVHPPSRQPIPRKRPATYNLWSND

PF10162 // ENSGT00780000121902_0_Domain_18 (3171, 3309)

SFWQSSRENN
YTVPHPGANVIIPEGTWIVADTEMPPMERLIIWGVLELEDK-YHVGAAATSPRKVVLNAT
YISLQGGRLIGGWEDDPFKGELNIVLRGNHSTPEWALPEGPNQGAKVLGVFGELDLHGIP
HSIYKTKLSETAEAGSKVLSLTDAVDWQEGEEIVITTTSYDFHQSETRSIVKILHDHKIL
ILNESLSYTHLAERYHVLETGQSYALAADVGILSRNVKIVGEDYPGWSKDSFGARVLVGS
FTENMITFKGTAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEHGASYLRGCAFH
HSFSPAIGVFGTDGLDIDDNIIHFTVGEGIR-IWGD-ANRVRGNLVSLSVWPGTYQNRKD
LSSTLWHAAIEVNRGTNTVLQNNIVAGFGRAGYRIDGEPCSSQSNPEEKWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFSMIYTPAAVSHKVSNKKVKIKSSLIVGSSPKFNCSDVLTDDDPSIELT
AAHRSPRPP--------------------T--GGRSGICWPTFASDHNMAPRKPHAGIMS
YNAIGGLMDISG--STFVGFKNVCLGETNVIFITNPLNEDLQHPIYVKNIQLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLRDMDGSFLGNSGSVIPQAEYEWDGNSQLGIG
DYRIPKVMLTFLNGSRIPVTEKAPYKGIIRDSTCKYIPEWQSYKCFGMEYAMMVIESLDS
DTETRRISPVAIVSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNKFYEVYFTG
TSPQNLRLLLLNVDYDKAVVVGIFFSTLQRLDVYVNNWLVCPKNTVWNAQQKYCELK--E
HLGTEQFLPNLDSTLVGENYFDRTYQMLYILVKGTTPVEIHTATVIFVSFQLPVVTEDDF
YSSNNLVRNLALFLKIPSDKIRISKIIRGERLR--RKRSL-GLTIELEIGEPPTQFLSND
TTGQ--MQLS-ELQEI--IDSLGRAVILGKSSSSLGFNISSMSITNPLPSPSDPEWIKVT
AQQVERSAFAFPVHHVAFVSSLSVIIQPVATQPGQPFSQQPSVKAGDSDGNCVSVEITTL
TLKAILKDSNNNPVSGLSGNTTIPFSSCWANYTDL--TPPLQTGKNFKIEFILDNVAWV-
----ESRPFSLPAQSVSSSSSSSSS------------------SSSSNSKASTVGTSAQI
MTTAISCLLGRMLLLEIFMAAVFVLNVTIGEY----------------------------
-------------

----------------------------MGH-LW--LLGI---WGLWGL-------LLCA
ADPST-----DGSQII

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 166)

PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAELGNS
VQLVSSFQSITCDVEKDASHSTQITCYTRAMPEDSYAVRVSVDGV

ENSGT00780000121902_0_Linker_1_2 (166, 199)

PVTENNTCKGHINSW
ACTFNA-------KSFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRIFTDVYGSNIALSSNG-KNV
RILRVYIGGMPCELLIPQSDNLYGLKLDHPNGDMGSMVCKTTGTFIG--HHNVSFILD-N
DYGRSFPQKMA-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFVSSLNKI-SMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 430)

EVTMIFPS
QGSIRGGTTLT-ISGQFFDQTDFPIRVLVGGEP----CDALNVTENSICCKTPP-KPH-I
FKAVYPGGR

ENSGT00780000121902_0_Linker_3_4 (430, 453)

GLKLEVWNNSRPIHLEEILEYDE

PF07691 // ENSGT00780000121902_0_Domain_4 (453, 558)

KTPGYMGASWVDSASYIWPLEQDTFVAR
FSGFLVAPDSDVYRFYIKGDDRYAIYFSQTGLPE--DKVRIAYHSANANSYFSSPTQRSE
DIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYQNVYTEQQTGDAVNEEQVIKSQSTIIQE
VQVITLENWETTNAINEVQKIKVTSPCVEANSCSPYQYRLIYNMEKT----VFLPADASE
FILQSALNDLWSIKPDTVQVTRT-QNPQSNIYTVTFISTRGDFDLLDYEVVEGNNVTLDI
TEQTKGKPNLETFTLNWDGIASKPLTPWSSEAEFQGAVEEMVSTKCPPQIANFEEGFVVK
YFRDYETDFNLEYINRGQKTAETDAYCGRYSLKNPAVLFDSADVKPNRRPYGDILLFPYN
QLCLAYKGFLANYIGLKFQYQDN-SKITRSTDIQFTYDFAHGN-NWTYTCIDLLDLIRTK
YTGTNVSLQRISLQKASESQSFYVDVLYIGHTSTISTLDEMPKRRLPALANKGIFLEHFQ
VNRTETNGPTMTIQYSVTMTSYNCSYNIPMMAVSFGQIITHETENEFVYRGNNWPGESKI
HIQRIQAASPPLSGSFDIQAYGHILK-GLPAAVSATDLQFVLQSLEGLGKVSVTREGTCA
GYAWNIKWRSTCGKQNLLQINDSNIIGEKANM--TVTRIKEGGLFRRHILGDLLRTPSQQ
PQVEVYVNGIPAKCSGDCGFTWNSDIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1243)

PLVLATSPSQGSYEEGTILTIVGSGFSPSS---
AVSVSVGPVGCSLLSVD-E-KEIKCQILNGSAGPAPVAVSIA

ENSGT00780000121902_0_Linker_5_6 (1243, 1263)

DVGLAQNVGG-EQFYFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHIWPDSGSIA-GGTLLTLSGFGFNENSKVLVGNATCNMIEGDLNRITCRTPKKTE
GIVDISVTTNGFQVTARDAFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YNCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1433)

PIITDFSPKVRTI-----LGEVNLTIKGYNFGN
ELTQNMAVYVGGKTCQILHWNFTDI-RCLLPKL-------SPGKQDIYVEVR

ENSGT00780000121902_0_Linker_7_8 (1433, 1453)

NWGFASI-
RDKLNSSIQYVL

PF01833 // ENSGT00780000121902_0_Domain_8 (1453, 1510)

EVTRMFPQRGSLFGGTE-ITIRGFGFSTIPADNTVLLGSIPCNITSSS
ENVIKCILH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGNLFRITNNGKDSVHGLGYAWSPSVLNVSVGDTVAWHWQTHPFLRGIGY
RVFSVSSPGSVIYDGKGFTNGRQKSTSGSFSYQFTSPGIHYYSSGYIDEAHSIFLQGVIN
VLPAETRHIPLHLFVGSSEATYAH----GEPENWHLGSSVAGCLATEPLCGLDNTRVKNS
KRLLFEVSSCFS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1760)

PSISNITPSTGTVNELITIIGHGFSNLPCANKV-TIGSYPCVVEESSE
DTITCHIDPQNSMDVGVRE

ENSGT00780000121902_0_Linker_9_10 (1760, 1787)

IVTLTVYNLGTAINTLSNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVLPNAGSTT
GMTRVTIKGSGFAVSSAGVKVLMGHFPCKVLSVDYTSIECETSPAAQQLVNVDLLIHGVP
AQCQGNCTFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLESIT

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1956)

PYITGVFPNSVI-GSVKVLIEGEGLGTVLEDIAVFIGNQQFRAV
EVNENNITALVTTLPVGHHSLSVVMGSKGLALGNL

ENSGT00780000121902_0_Linker_11_12 (1956, 1962)

TVSSPP

PF01833 // ENSGT00780000121902_0_Domain_12 (1962, 2039)

VASLSPTSGSIGGGTTLVI
TGNGFYPGNTTVTIGDDPCQIISINLNEVDCLTPAGTNGMVGVKIFVNTIAYPPLLFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
LEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLRGIIPSR-GPPGTEIEITGSNFGTEILEISVMINNIQCNVTMANDSVLQCIVG
DHAGGTFPVMMHHKTKGSAVSTVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPL

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

NIQNINPSQG-SFGGGQTMTVTGTGFNPQNS
IILVCGSECAIDRLRSDYTTLLCEIPSNNG-TGAEQACEVSV---VNGKDLSQSMTPFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
AVSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2309)

PLITAVSPRRGSTAGGTRLTVMGSGFSENVEDVHITIAEAKCDVEYSNKTHIICM
TDAHTPSGWAPVRVHIRGVGMAKLDNAD

ENSGT00780000121902_0_Linker_15_16 (2309, 2321)

FLYIDAWSSNFS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGQSPPEEGSLVVITKGQT
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGILQIGTETSPFQHKAVITLH
GHLRSPELPVYGAKTLAVREGILDLHGVPVPVIWTHLARTAKAGERILILQEAVTWKPGE
NIVIASTGHRHSQGENEKRTIASVSADGINITLSNPLNYTHLGITVTLPDGTLFEARAEV
GILTRNILIRGSDNVEWNNKIPACPDGFDTGEFATQTCLQGKFGEEIGSDQFGGCIMFHA
PVPGANMVTGRIEYVEVFHAGQAFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIQHNAVAGGTHFGFWYRMNNHPDGPSYDRNICQKRVPLGKFFNNTVHSQGWFGMW
IFEEYFPMQTGSCTSTVPVPAIFNSLTTWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGETNGAVIKNAKIVGHLDELGMGSAFCTTKGLVLPFSEGLTISSVHFMN
FDRPKCVALGVTSISGVCNDRCGGWSAKFVDIQYFHTPNKAGFRWEHEMVLIDVDGSLTG
HKGHTVIPHSSLLDPSHCTQEAEWSIGFPGSVCDASVSFHRLAFNQPSPVSLLEKDVVLS
DSFGTSIIPFQKKRLTHMSGWMALIPNAKHINWYFKGVDHITNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNIIDMRNGSSNPLNWNTSKNGDWHLEANTSTLYYLVSGRNDLHQSQPI
SGNLDPDVKDVVINFQAYCCILQDCFPVHPPSRKPIPKKRPATYNLWSNDSF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3309)

WQSSRENN
YTVPHPGANVIIPKGTWIVADIDMPSMERLIIWGVLELEDK-YNVGAAESSYREVVLNAT
YISLQGGRLIGGWEDNPFKGDLKIVLRGNHTTPDWALPEGPNQGAKVLGVFGELDLHGIP
RSIYKTKL

ENSGT00780000121902_0_Linker_18_19 (3309, 3470)

SETADAGSKVLSLMDAVDWQEGEEIVITTTSYDFHQTETRSIVKILHDHKIL
ILNDSLSYTHLAEKYHVPGTGESYMLAADVGILSRNIKIVGEDYPGWSKDSFGARILVGS
FTENMMTFKGNAR-ISNVEFYHSGQEGFRDSTDPRYAVTFLNLGQIQEH

PF13229 // ENSGT00780000121902_0_Domain_19 (3470, 3663)

GSSYIRGCAFH
HGFSPAIGVFGTDGLDIDDNIIYFTVGEGIR-IWGN-ANQVRGNLIALSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNVVAGFGRAGYRIDGEPCSGQFNPVEKWFDNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWTCWDYGIYFQ----------------TTESVHIY
NVTLVDNGMAIFPMIYMPAAISHKISSKKVQIKSSLIVGSSPGFNCSDVLTNDDPNIELT
AAHRSPRSP--------------------S--GGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDISG--STFVGFKNVCSGETNVIFITNPLNEDLQHPIHVKNIKLVDTTEQSK
IFIHRPDISKVNPSDCVDMVCDAKRKSFLKDIDGSFLGSAGSVIPQAEYEWDGNSQVGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGIIRDSTCKYIPEWQSYQCFGMEYAMMVIESLDP
DTETRRLSPVAIMGNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHSIVALNTSYEVYFTG
TSPQKLRLMLLNVDHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTIWNAQQKYCELN--N
HLYKDQFLPNLDSTVLGENYFDRTYQLLYLLVKRTIPVEIHTATVIFVSFQLPAATEDDF
YTSHNLVRNLALFLKIPSDKIRISKMIRGKSLR--RKRSM-GFIIEIEIGDPPIQFLSNG
TTGQ--MQLS-ELQVI--AGFLGQAVISGKISSILGFNISSMTITNPLPRPSDSGWIKVT
AQPVERSA--FPVHYVAFVSSLLVITQPVAAQPGQPFPQQPSVKATDSDGNCVSVGITAL
TLRAILKDYNNNQVNGLSGNTTIPFSSCWANYTDL--T-PLRTGKNYKIEFILDNVVWV-
----ESRTFSLLAESVSSSSSGSSSS----------------------SSTSTVGTYAQI
MTVVISCLIGRMWLLEILMAAVSTLKITLSKYSPL---IQYFST----------------
-------------

----------------------------MSHHCI--IVGY---WNLFGKRGLGHRGTFCS
ADSNK-----YGQRIVT

PF01833 // ENSGT00780000121902_0_Domain_1 (78, 164)

KVTEIIPKYGSINGATRLTIKGEGFAQGNQFNYGVDNELLGNS
VHLVSEIRSIPCDVEKDASHATQIICYTRPMPEDTYIVQVIVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVVDNNICKGLINNW
KCSFSA-------KLFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIMSIKPSSGLPGAVITIHGRIFTDVYGSNTALSSNG-KNV
RILRVYVGGMPCELLKPDSDDLYGLKLDHQNNDMGSVVCKMTGTYVGH--HNVSFILD-S
DYGRSFPQPST-

ENSGT00780000121902_0_Linker_2_3 (313, 353)

YFISSLHKI-AMFQTY-----------------------A

PF01833 // ENSGT00780000121902_0_Domain_3 (353, 424)

EVTSIFPG
QGSIQGGTLLT-IRGQFFDQTVYPARVLVGGQI----CAVQAVTDNSIHCRTPP-QPR-N
LKT

ENSGT00780000121902_0_Linker_3_4 (424, 430)

VYPGGR

PF07691 // ENSGT00780000121902_0_Domain_4 (430, 558)

GLKLEVWNNSRPAHLEEVLGYNESTPGYMGTTWVDSASHFWPVEQERFVAR
LSGFLVAPDSDSYRFYIKGDDRYALYFSQTGDPE--DKVKIAYHSSYANSYFSSNTQRSD
VFHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

QYGLSAFVDVGMFQCKNSYSEKQTGDAVNEEQIIQSQSTVVAE
IQVITLVNWTTAGAINEVQTITVSSPCMDSNMCSDTQYRLIYNKEKT----VMLPADAPG
SALQSALNDLWSIKPDTVQVSRT-EGNQGYVYSVTFISDRGDFNLLGYEAPEGNNVTVDV
VELTKGKPSLDTFTLKWDGISSRPLKPWASGAEVQAALEELVSAKCPKKIAHFTEGFIVQ
YFRDYETDFRMEDNKRGQKTSETDAFCGRYSLKNPAILFDSADMKPSQHTYGAISLFPYH
YLCLAYKGFLAHEIGLKFQYQDSNK-STRSTDKWLSFNFAEGNMNWTYTCIDLLSLIQEK
HPGNNFLLQRINLKKASEAQSFYVDVVYIGQKATFSTANGVPKRRLPALANKGIFFKQFQ
VNQTQTDGSFLTNSYSVTMSSHNCSYRIPLLAVDFTQAVTN-TENESVFRGTNWPGESHV
LIKRIQTASPPLHGSFDIQAYGHLLQ-GLPADVSAVDLKYALQSIAEMGEVSVTRQGSCS
GYLWRVKWKSAYGNQNLLQINDSNITGVNVNM--SATKTREGGVFRTHVLGDLFRTPNHQ
PQVEVYINGLPSKCSGDCGYKWDNQNT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1249)

PIISSISPTQGSYEEGTVLIISGSGFSGSSGSE
TTRVTIGEVNCSIFSIS--ENEIQCHIQNGSGGTFPVALSIAAFGLVE

ENSGT00780000121902_0_Linker_5_6 (1249, 1263)

NAGE-KGFNFTY
RT

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISQVWPVSGSLA-GGTLLTVSGFGFNQDSKVLVGNKSCSVLKGNFKEIKCRTPMGPE
GTVDVTVFTNGLHATVNSTFNYSHLWTPVITDFSPKTRK-----VFGKESSVATHISPVI
EN--STTGFVINPHHSILLYAMIIIILSLVSNLSFYYHTFIKRSYFKDDFVPSWGTFR--
--------ASILNPHHLAPENCGIEGGISFNSFSGESNSLLDLRREGVLGSFPCHVTTSS
ENLIKCTLQSTRSTYRVTNSGKHSVYGLGYAWFPAVLDVSVGDRVIWQWQTQPFIRGVGY
GVFSVSSLGSVVYDGKGFTSGTRRTKSGSFSYQFTSPGIYYYSSGFIDEAQSIFLQGVIN
VLPNEDRDIPLHLFIDEIEATYVK----GVPEMSPFGRSGSECIEPEPLCPQLVNGIENS
PGFSFKLSSCSS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1769)

PSIINISPSSGTVRDLITITGSGFSNITCAHEV-TIGGHPCITKGVSE
NSIMCQLDPQNSMDIGIGELVSLTVHNL

ENSGT00780000121902_0_Linker_9_10 (1769, 1787)

GTAINTLTNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1870)

PHVDSVTPIAGSTT
GMTRVTIRGSGYAASLSDIKVTMGDFPCRVGSANYTTIECETSPAPEHLGDVNVQIRDVL
ARCPGACSF

ENSGT00780000121902_0_Linker_10_11 (1870, 1877)

SYLDGIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1948)

PSVTRVNPIVLQTSPTEVLIEGEGFGTILEDIAVYVGHIQVTAA
SVNEKNITVIATAVPAGSYPLCVVVAT

ENSGT00780000121902_0_Linker_11_12 (1948, 1960)

KGRAFGNFAIIS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2029)

PAVASLAPTSGSLRGGTILII
TGSGFCPGNTTVTIGSNPCLIVSVTYDEVQCLAPARSASTVLVKIVVNSVIYPILAFTYS
LDATPFVKEVIPAR-GKPTTTCFS---QFYYDPSLGPL----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------

----------------------------MGH-LW--LS-G---WFLFGL-------LWCA
ADSHT-----GTSETV

PF01833 // ENSGT00780000121902_0_Domain_1 (77, 164)

PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNIELGNH
VQLVSSFQSITCDVEKDSTHSTQITCYTRAMPEDVYSVRVSVD

ENSGT00780000121902_0_Linker_1_2 (164, 199)

GVPVAENNTCKGVVSSW
ACSFST-------KRFRT

PF01833 // ENSGT00780000121902_0_Domain_2 (199, 313)

PTIRSITPLSGTPGTLITIQGRLFTDVYGSNTALSSNG-RNV
RILRTYIGGMPCELLIPHSDDLYGLKLDHPSRDTGSVTCKATGTYIG--HHNVSFILD-S
DYGRSFPENTT-

ENSGT00780000121902_0_Linker_2_3 (313, 355)

YFVSSLNKI-SMFQTY-----------------------AEV

PF01833 // ENSGT00780000121902_0_Domain_3 (355, 437)

AMVSPS
KGSPEGGTILT-IHGQFFDQTDLPVRVLVGGQA----CDILNVTENTIYCKTPP-KPH-V
LKATYPGGRGLKIEVW

ENSGT00780000121902_0_Linker_3_4 (437, 440)

NNS

PF07691 // ENSGT00780000121902_0_Domain_4 (440, 558)

RPTHLEDILEYSEQTPGYMGASWTDSASYVWPIEQDTFVAR
ISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGHPE--DKVRIAYYSRNANTYFSSSTQKSD
EIHLQKGKEYYIEILLQ

ENSGT00780000121902_0_Linker_4_5 (558, 1168)

EYTLSAFVDVGLYQYKSVFTEQQTGDALNEEQVIKSQSTVIPE
VQIITLENWETADAIKEVQQVTVTSPCVGANSCSLSQYRFIYNMEKT----VWLPADASA
FMLQSALNDLWSIKPDSVQVTSK-RDLQSYIYTITFASTRGDFDLLGYEVFEGSNVTLNI
TEHTKGKPNLETFTLNWDGIASKPLTPESSEAEFQEAVEEMVSAKCPPEIAHLEEGFLVK
YFRDYETHFELEHNNRAQKTAETDAFCGRYSLKNPAVLFDSTDVKPNKLPYGDILLFPYN
QLCLAYKGSLANFIGLKFKYEDS-GKIIRSADMQFEYNFASGN-KWTYTCIDLLDFLQTK
YAGTSFSLQRISLQKSSEFQSIYVDAVYIGQIPTVSVLDEMPKRRPPALANRGIFLKHFQ
VDQTKLSESALTIQYSITISFYNCSHNIPMMGVSFGQIVTNETKNESVYRGNNWPGESKI
RIRKIQEASPPVSGSFDIQVHGHTLK-GIPAAVPAADLQFALQSLEEIERVSVSREGTCA
GYSWSINWKSPCGKQPLLQINDSNILGEKASV--TVTSIKEGGLFRQRIPGDMLRTPNQQ
PQVEVYVNGIPAKCSGDCGFTWDAMIT

PF01833 // ENSGT00780000121902_0_Domain_5 (1168, 1249)

PLILTTTPSEGSYAESTILTIAGSGFSPTS---
AVSVSVGSTQCSLLSVE-E-NEIKCQILNGSAGHVPVAVSIAGVGLAQ

ENSGT00780000121902_0_Linker_5_6 (1249, 1263)

NLEG-EGSHFVY
QS

PF01833 // ENSGT00780000121902_0_Domain_6 (1263, 1342)

QISHVWPDSGSLA-GGTLLTISGFGFSKNSTVLVGNETCNVIEGDLNRITCRTSKRIE
GTVDISVITNGIQATSKDSFS

ENSGT00780000121902_0_Linker_6_7 (1342, 1348)

YSCLQT

PF01833 // ENSGT00780000121902_0_Domain_7 (1348, 1437)

PVVTDFSPKERTI-----LGTVNLTIKGYNFGS
ELTQNT-VYVGGKHCQILHSNFTDI-TCLLPTL-------PPGKHEIYVKVRNWGL

ENSGT00780000121902_0_Linker_7_8 (1437, 1454)

AST-
RNKLNASILYILE

PF01833 // ENSGT00780000121902_0_Domain_8 (1454, 1510)

VTHMFPQRGSLYGGTE-ITIIGSGFSTIPTENSVLLGSFPCDITSSS
ENVIKCTLH

ENSGT00780000121902_0_Linker_8_9 (1510, 1693)

STGAVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWYWRAHPFLRGIGY
RIFSVSSPG-VTYDGKGFTNGRQKSASGSFSYQFTSPGVHYYSSGYVDETHSISLQGVIN
VVPAETRHIPLHLCVGNIEATYVP----AGPVHLPLASTASGCLATEPLCGLNDTRVKHS
NKLFFELSNCVS

PF01833 // ENSGT00780000121902_0_Domain_9 (1693, 1758)

PSIINITPSTGTANELITITGHGFSNLTCANKV-TIGSYPCVVEESNE
NSIMCHIDPQNSMDVGI

ENSGT00780000121902_0_Linker_9_10 (1758, 1787)

REIVTLIVYNLGTAINTQPNEFDRRFVLL

PF01833 // ENSGT00780000121902_0_Domain_10 (1787, 1871)

PNIDLVMPKAGSTT
GLTRVTIQGSGFMASSAGVEVFMGDFPCKVLNVTYTAIECETSPAPHQLVLVDLLIHGVP
AQCQGNCSFS

ENSGT00780000121902_0_Linker_10_11 (1871, 1877)

YLDNIA

PF01833 // ENSGT00780000121902_0_Domain_11 (1877, 1954)

PYVTGVFPNSIQ-GSGSVLIIGEGFGTVLEEISIFIGIQKFRVL
DVNENNITVLMTPLAAGLHSLSVVVGSKGLALG

ENSGT00780000121902_0_Linker_11_12 (1954, 1960)

NLSVSS

PF01833 // ENSGT00780000121902_0_Domain_12 (1960, 2039)

PAVASVSPTSGSIAGGTTLMI
TGNGFSPGNTTVTVGDQPCQIMFINSSEVHCSTPAGRAGTANLKIDVNSVIYPSLSFT

ENSGT00780000121902_0_Linker_12_13 (2039, 2045)

YA
MEDT

PF01833 // ENSGT00780000121902_0_Domain_13 (2045, 2127)

PFLKSIIPNS-GPPGTEVEITGSNLGFAVSDVLVMIKESVCNVTTVNDTVLQCIVG
EHAGGIFPVMMLHKTKGSAISSVVFE

ENSGT00780000121902_0_Linker_13_14 (2127, 2130)

YPF

PF01833 // ENSGT00780000121902_0_Domain_14 (2130, 2220)

SIQSISPRKG-SFGGGQT-TVTGMGFDPWNS
TILVGGSECAVDKLLSNSTT-LCEIPPNNG-KGPDQACGVSV---VNGKDSSQSVTLFT

ENSGT00780000121902_0_Linker_14_15 (2220, 2226)

Y
MLSLT

PF01833 // ENSGT00780000121902_0_Domain_15 (2226, 2298)

PLIIEVSPRRGSTAGGTRLTVTGSGFSENTEDVQVTIANSKCDVQYSNKTHIVCM
TSAHAPSGWAPVLVNIK

ENSGT00780000121902_0_Linker_15_16 (2298, 2321)

NIGVAKLENADFLYADVWSANSS

PF10162 // ENSGT00780000121902_0_Domain_16 (2321, 2438)

WGGKLPPEEGSLAVITKGQI
ILLDQSTPILKMLLIQGGTLIFDEADIELQAENILITDGGVLQIGTEAFPFQHQAVITLH
GHLRSPELPVYGAKTLAVREGTLDLHGLPIPVVWTRLAHTANAGEWTLTVQEAVTWKTGD
SIVIASTGHRHSQGENEKRTIASVSADGMHITLTRPLNYTHLGITTTLPDGTVFEARAEV
GILTRNILIRGSENVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHA
PLPGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVRGCAIHQAYNRAVTI
HNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVT
NPNNTIRHNVAAGGTHFGFWYRMNDHPDGPSFNRNICQKRIPLGEFYNNTVHSQGWFGLW
IFEEYFPMHTGSCTSTVPVPAVFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNYEAGIET
KRILAPYVGGWGESNGAVIKNAKIVGHLDELGMGSTFCTSKGLVLPFSQGLTVSSVHFMN
FDRHACVALGVTSITGVCNDRCGGWSAKFVDIQYFHAPNKAGFRWEHEAVLIDVDGSLTG
HRGHTVIPHSPLLDPSHCTQEAAWSIGFPGSVCDASVSFHRLAFNKPSPVSLLEKDVVLS
DSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVI
ISHNFTQNPDMFNVVDMRNGSSNPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPI
SGTLDPDVKDVIINFQAYCCVLQDCFPVHPPSKKTIPRKRPATYNLWSNESF

PF10162 // ENSGT00780000121902_0_Domain_18 (3173, 3308)

WQSSPENN
YTVPRPGANVIIPEGTWIVADMDIPPMEKLIIWGVLEMEDK-SEVGAAGPAYRKVVLNAT
YISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWALPDGPNQGAKVLGVFGELDLHGLP
HSVYKTKLLETAEAGSKILSLVDAVDWQEGEDIVITTTSYDLHQTEIRRIAKVLHGRKVL
ILNDSLSYTHLAERQWIPETSQSYTLSADVGILSRNIKIVGEDYSVWSKDSFGARILVGS
FTGNMMTFKGNAR-ISNVEFYHSGQEGYRDSTDPRYAVTFLNLGQIQDHGLSYVRGCAFH
HGFSPAIGVFGTNGVDIDDNIIYFTVGEGIR-IWGD-ANRVRGNLVTLSVWPGTYQNRKD
LSSTLWHAAIEINRGTNTVLQNNIVAGFGRVGYRIDGEPCSSQANPMENWFNNEAHGGLY
GIYMNQDGLPGCSLI-----QGFTIWACWDYGIYFQ----------------TMESVHIY
NVTLVNNGMAIFSMIYMPSSVSHKVSSKTVRIKNSLIVGSSPEFNCSDILTNDSPDVELT
SAHRSSRP----------------------PSGGRSGICWPTFASAHNMAPRKPHAGIMS
YNAISGLLDVSG--STFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLVDTIEQSK
VFIHRPDISKVNPSDCVDMVCDAKRKSFLKDLDGSFLGNSGSVIPQAEYEWDGNSQLGIG
DYRIPKAMLTFLNGSRIPVTEKAPHKGILRDATCKYIPEWQSYQCLGMEYAMMVIESLDS
DTETRRLSPVAIMSNGYVDLIN--GPQDHGWCAGYTCQRRLSLFHGIVALNKTYEVYFTG
TSPQNLRLMLLNVEFNKVVLVGIFFSTLQRLDVYVNNSLVCPKNTVWNDQKKHCELE--R
HLNTEQFLPNLGSTVPGENYFDRTYQMLYLLLKGTTPVEVHTATVIYVSFQLPAMTADEF
FSSNNLVRNLALFLKIPSDKIRVSRIIG-ASLR--RKRST-GRIMEFEIGAAPTRFLSNS
TTGQ--MQLS-ELQEI--TGCLGQAVILGKISTILGFNISSMSITSPIPQPTDSGWIKVT
AQPVERSA--FPVHYLALVSSLSVVAQPVATQPGQPFSQQPSVKAVDPEGNCVSVGITSL
TLKAILKDSNNNQVGGLSGNTTIPFITCWANYTDL---TPHRTGKNYKIEFVLDNSVRV-
----ESRPFSLSAQTVPGGSGSSS--------------------SSGHSKASSVGTPVQT
LAIVIGCLVGRLLLLEVFMATVFILKTTI-------------------------------
-------------