Query Results 

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------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 383)

KAGKRP-PSPALWWVNGKGKELMW--NFRELSENSQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKSA-D--ILYRLQMSQAKAIVAGDEVFQEV
DTVASECPSLRIKLLVSE-KSCDGWLNFKKLLKY-KVRHREVK-----------------
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-------------------------------------------MVIWNTEESEIDGS---
------HSWK-----------------TGLIDSPDLGIKTLTMLWLGKI----PRYCTLW
GTEMS---IRTFHIN--IKKLLSIQW---------G--HQ-EIPAKFNFANDVIDHWANM
EKAGKRP-PRPALWWMNGSGEELKW--NFRELSEISQRAANVLSGACGLQRGDRVAVVLG
QVPEWWLVTLGCIRT--GLVFM--PGTIQMKST-D--ILYRLQSSKARAIVAGDEVAQEV
DAVAPDCSFLKIKLLVSE-NRREGWLNFKTLLKD-VSTTHHCVET---------------
------------------GSHEPAAIYFTSGTSGPPK-MAEHSHSSLGLKAKM--DAG--
---SWTGLNV---SDTVWTISD------------------------TGWIVNILASFLEP
WTLGACIF-------------------------------VYLLPKFNPQTVLKV----LS
SYPINSLVGAPL---IYRMLLQ---QDLS-------------SYK----FPHLHSC----
----FTGGESLLPETLEN--------WKAKTGLY---IREFYGQTET-GLT---CRVSRT
MTVKPGFLGTA--VPHYDVQ------------VIDEQGNVLPPGKEGDIAI-RVKPIRPV
GIFSGYV-------------------DNPKKTEANIRGDFWLL--GDRGTKDSEGYFHFM
GRTDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVAETAVISSPDPT-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--ITGKI--------ER-AKL---RAKEWKTSGQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

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------------------------------------------------------------
-----------------------------------------MRPWLRGL-----VLQALK
NSRRC---CRSH-GQPPPPLVLQKAVANWEAI-SLG--KQ-PMPEYFNFAHDVLDVWSQL
EKDGHRP-PNPAFWWVSGTGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGKQSRKAANVLTGACGLQPGDRMMLVLP
RIPEWWLVSVACMRT--GTIMI--PGISQLTEK-D--LKYRLQSSKAKAIITSDSLAQRV
DAISGDCPSLQTKLLVSD-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSQDPMVIYFTSGTTGTPK-MIEHSHCSYGLGFVA----SGR
---RWVALTE---SDIMWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPQVDAKFILNT----LC
AFPITTFCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKQQTGLE---LHEGYGQSET-VVI---CANTKG
MKIKSGSMGKA--SLPYDVQ------------IVDDEGNILPPGEEGNIAV-RIRPTRPF
CFFNGYL-------------------DNPEKTARSEQGDFYIT--GDRAHMDKDGYIWFK
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESVLA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPEYTSHDPEELTRELQDHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKL--------QR-GKL---RSQEWGK-----------------------------
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-----------------------------------------MRLWLRGL-----VLQALR
STRGV---CGSC-GQPPPLPVPQKIVATWEAI-NLG--RQ-PVPEYFNFARDVLDVWTQL
EKAGHRP-PNPAFWWVDGLGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGVQSRKAANVLGGVCGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GAVMI--PGVSQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISTDCPSLQTKLLVSD-SSRPGWMNFRELFRE-ASTEHDCVRT---------------
------------------KAQDPLAIYFTSGTTGAPK-MVEHSQASYGLGFVA----SGR
---QWVALTE---SDIFWNTTD------------------------TAWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILKT----LS
RLPITTLCCVPT---LFRLLVQ---EDLTR-------------YQ----FQSLRHC----
----LTGGEALNPDVREK--------WKSQTGLE---LHEGYGQSET-VVI---CANPKG
TKIKSGSMGKA--SPPYDVQ------------IVDDEGNILPPGAEGNVAV-RVRPARPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------AS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEELTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWKK-----------------------------
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-----------------------------------------MK-ILLHY----QRFRFIW
LAKPA---GRHFHKH--PQLQTPLTLADFEAI-NRC--EK-PLPKNFNFAADVLDQWSQK
EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACIRT--GLVFM--PGTTQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPNLKTKLLVSP-DRWDGWLNFQELLPL-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTP---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANCKG
QEIKPGSMGKG--VVPYDVQ------------IIDESGNVLPPGKEGEIAL-RLESTRPF
CFFSEYV-------------------DNPEKTAATIRRNFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPFKSSNREKLIAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
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-----------------------------------------MRLWLRGL-----LLQTLR
SFRGF---CGSP-GQQAPLPTPPKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQM
EKAGHRP-PNPAFWWVDGMGAEVRW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 482)

SFEELGRQSRKAANVLGGVCGLQSGDRMMLVLP
RIPEWWLVSVACMRT--GAVMI--PGVSQLTEK-D--LKYRLQVSRAKTIITSDSLAPQV
DAISADCPSLQTKVLVSD-LSRPGWIDFREHLRE-ASAEHTCVRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQCSYGLGFLG----TGK
YMSRFNEKDS---NIQVQNLT---------------------------------------
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DQEGRRV-PNPALWWVNNEGNEVKW--SFGEMTDLTCHVANIFSQICGLQPGDGLA----
LVPVWWLVTVGCIQT--GITFM--LGTTQMRAR-D--ILYQLLASKAKGVL-TDTLAPEV
DSVASECPALKVKPLVSD-HRHKGGQNFPSLIKL-FSSNPKANVLAKSHLMQESKLIKHS
IRTLLKAWGRGSASPEHTCIKDPMAIFFTSGPQATP--RWQNTAMDLTYDPP--------
--------------SLCRRKQD------------------------TTWEAG-----SHI
WDRGLCGFRPLEPERNEHGRVIRPLKPSPFSKV--MVTGAP---SIEMSDLDVT----VN
MAS----RGHCS---SRPVMLN---PDCTVTI----FKELKTTT-----AKKMHSCL---
------------GPSSE------------------------VLVKLN-WDS---PQQWFH
SDAQPAMLGIK--KVPSRGP------------MVSKSSPM-N--------C-TAVPGAHQ
GVHCWTL------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (806, 910)

-GDPKKTAKVECGDFYNT--GDKAGMEAEGYFWLL
GRSDDIINA-----------------------------SG-----F-CIRP-AEVEDALA
EHPTVAKSAVINSPDPI-RKE--------------------------------VV-ACIV
LTPPFLSHDQDQLTKELQQYMKSVAAPYEYPRK--VSW----------------------
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-----------------------------------QSSFGVMKIFF-RY----QTFRFIW
LTKPI---ARHFHKD--HQLWAPLTLNDFEAI-NRC--QK-TLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACIRT--GLVFM--PGTTQLTAK-D--ILYRLQASKARCIVANEEVAPAV
ESIASACPNLKTKLLVSP-HSRNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHTQSSLGIGYTL----CGR
---YWLDLKA---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKKQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGHILPPGKEGEIAL-RVNSTWPF
CFFTEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRRA----------------------------
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------------------------------------------------

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------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTIAD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILK-------
------------------------------------------------------------
------------------------------------------------GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
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------------------------------------------MKLLSRLLVLKHTFAPKW
PYQIK---SQAC------SGAPSLDF---------P--ESEAVPEYFNFAKDVLDAWAQK
ETDGRRP-SNPALWWVDDQGEEVRW--GF

PF00501 // ENSGT00760000119178_4_Domain_0 (270, 910)

EELGFHSRKAASALSEGCRLDKGDGLLLVLP
RVPEWWMISVGCMRT--GIVSI--PGTTQLTSK-D--LLYRLQASKAKCIITNDALAPLV
DSVASECHALKNRVLVSKGRRREGWLDFHDLVEA-ASDKHQPVQT---------------
------------------KSQDPVSIFFTSGTTGYPK-MVKQSCANLGIGMRN--I--GR
---TWMNLNP---SSVMWGVSD------------------------TGWVKFQFSSLYAT
WIEGACVF-------------------------------AHGKAQFDSLVVLNC----LS
KYPVTTFCGTPT---IFRMLLQ---HDVR-------------RYK----FKSLVSC----
----LSGGEPLPPEVSAQ--------WKAQTGME---IYEGYGQTET-TLV---CATTRD
MKVKPGFLGKA--HPPYDVQ------------IIDKHSNPLPLGEEGDIGI-RIKPKRPL
GLFLGYV-------------------DDPLKTASTERGDFYIT--GDRGVMAEDGYIHFV
ARADDVILS-----------------------------AG-----Y-RIGP-FEVENALL
GHPAVVEAAVVSSPDLI-RGE--------------------------------VVKAFII
LSPAYESHDKDKLILELQDHVKGTTAPYKYPRK--IEFVQ-DL--PK------T------
--ISGKV--------RR-KEL---RNKEWERSH---------------------------
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------------------------------------------MKLLMRP-------HVLR
GLWAAWPASGSLHPR--PRNLLTHPFSRTETT-QWG--DY-EIPKEFNFASDVLDHWAHM
EKEGKRD-PLPALWWVNNKGDEVKW--NFRELSDLTRQAANVLMETCGLQQGDYLILILP
RIPELWLLTVGCIRA--GLVIL--PGTPQLTAK-D--ILYRLQISKAKGIATTETLAPLV
DSMASDCPHLKVKLLVSE-QSRDGWLDFKMQL----------------------------
---------------------------------------------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (478, 910)

-NR
---QVLKLTS---SDVSWCVSD------------------------PGWILSVVGAMIEP
WTSGSCSF-------------------------------IHGMPQHDPMTILQT----LS
RFPITSMLTSAS---VYRMLLQ---LNVS-------------SYK----FPTLKNC----
----VSAGEVLLPQDFEK--------WKQATGLA---INELYGQSET-GIT---CAVSRG
MKVKKGSMGKV--VPPFDMQ------------IIDEEGNILPPGKEGEMAI-RIKPTRPI
GLFTSYL-------------------NDPEKTSLSERGDFYIT--GDRAMLDEEGYIWYL
GRSDDIINA-----------------------------SG-----Y-RIGP-SEVENALA
EHPAVAESAVIASPDPI-RGE--------------------------------VVKAFVV
LTPEFMTHDHNQLAQELQRHVKETTAPYKYPRK--VEFVP-DL--PK------T------
--VTGKI--------MR-SSL---RKIERGFNQ---------------------------
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------------------------------------------MYWLRKL----QGLCTLW
GTQMP---SHTLHIN--NRQLVSVPW---------G--HL-EAPPTFNFTRDVIDHWAEM
EKV

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GKRP-PGPALWWINGNGEEVMW--NFRELSEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWALVILGCIRA--GIVFM--PGTIQMKSA-D--ILYRLQMSKAKAIVAGDEVVQEV
DTVASKCASLRIKLLVSE-KSRDGWLNFKKLLKE-TSTTHRCVVT---------------
------------------GSQETSAIFFTSGTSGLPK-MVEHSHSSLGLKAKL--DAG--
----WTGLQV---SDVAWTIAD------------------------TGWTVKILGSF-ES
WATGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPVKTMLSAPV---VYQMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGDTLLPEILRN--------WKAQTGLD---IREFYGQTET-GLT---CRVSKT
MKIKPGYLGTA--MPNYDVQ------------VIDDKGNVLPPGKEGDIGI-RVKPNKPI
GILSGYV-------------------DNPEKTAANIRGDFWLL--GDQGIKDEDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVIGSPDPI-RGQ--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-SL--PK------N------
--ITGKI--------QR-AKL---RDKEWKKSGQTCAQRDV-------------------
------------------------------------------------------------
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------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGP-----VLQALR
RVRGT---CGSQ-GQPPPLPVPPKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVDGRGAEVQW--SFEELGEQSRKAANVLGGMCGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GAVMI--PGISQLTEK-D--LKFRLQASRAKSIITSDSLAPRV
DAISADCPSLQTKLLVSD-SSRPGWMNFRQLLRE-ASSEHSCART---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHTQASYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
SFPITTFCCIPT---IFRLLVQ---EDLT-------------RYQ----FQSLKHC----
----LTGGEALNPDVRGK--------WKSQTGLE---LHEGYGQSET-VVI---CANPKG
SKIKAGSMGQA--SPPYEVQ------------IVDDEGNVLPPGEEGNIAI-RVRPARPF
CFFRCYL-------------------DNPEKTAASERGDFYIT--GDRAHIDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLEAAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYTSHDPKKLTWELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRR-----------------------------
------------------------------------------------------------
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------------------------------------------------

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------------------------------------------MHWLRKL----QGICIQR
RTQIA---CRTVHIH--TKQRASLPW---------G--HQ-EVPARFNFASDVMDYWAGM
EKAGRRA-PGPALWWVSGRGEEVRW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

DFGQLQELSQRTANVLAGACGLQRGDRVAVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTIQMTAR-D--ILYRLQVSRARAIVAGEDVAQAV
DTVAPDCPSLKTKLLVSA-KGRDGWLDFKTLLQG-ASPTHRCVET---------------
------------------GGQEAAAIYFTSGSTGLPK-MAEHSHASLGVKAKM--DAG--
---LWTDLQA---SDLIWTITD------------------------TAWILNILCSFLEP
WTSGACVF-------------------------------IHLLPKFDPLAILQV----LS
SYPINNMVGAPI---VYRMLVQ---QDLS-------------SYK----FPHLQSC----
----FSGGEALLPGTLAS--------WRAQTGLD---IREFYGQTET-GLT---CRVSKT
MKVKPGCLGTA--IPHYDVQ------------VIDDQGHILPPGVEGDLGI-RIKPNRPI
GIFSGYV-------------------DNPEKTAANIRGDFWLM--GDRAIKDQEGYFQFM
GRADDIINS-----------------------------SG-----H-RIGP-GEVENALM
EHPAVVETAVISSPDPI-RGE--------------------------------VVKAFVV
LAPQFLSHDPEQLTRELQQHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--VSGKI--------QR-TKL---REQEWKRSGPARAP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
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------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELIW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASKCPSLRTKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETAAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTISD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPV
GVFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVAETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLCCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFRETADLTRRTANIFTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTIASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLIKS-ASPEHTCIKS---------------
------------------KTVDPMVIFFTSGTTGFPK-MAKHCHGL-ALQSSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------PGWILATMGALVEP
WTAGCTAF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFFGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLP---LYDIYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGNILPPNTEGNIGI-RIKPARPV
TLFMGYE-------------------GNPEKTAEVECGDFFNT--GDTGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLGKI----PRRCTLW
GTEMS---IRTFHIN--IKKLLSIQW---------G--HQ-EIPAKFNFANDVVDHWANM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PRPALWWMNGSGEELKW--NFRELSEISQRAANVLSGPCGLQRGDRVAVVLS
QVPEWWLVTLGCIRT--GLVFM--PGTIQMKST-D--ILYRLQSSKARAIVAGDEVAQEV
DAVAPDCSFLKIKLLVSD-NRREGWLNFKTLLKD-VSNTHHCVET---------------
------------------GSHEPAAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DA---
---DWTGLNV---SDTVWTISD------------------------TGWIVNILTSFLEP
WTLGACVF-------------------------------VYLLPKFDPQTVLKV----LS
SYPINSLVGAPL---IYRMLLQ---QDLS-------------RYK----FPHLHSC----
----YTGGESLLPETLEN--------WKAKTGLY---IREFYGQTET-GLT---CRISRT
MTVKPGSLGTA--VPHYDVQ------------VIDEQGNVLPPGKEGDIAI-RVKPFRPI
GIFSGYV-------------------DNPKKTEANIRGDFWLL--GDRGTKDPEGYFHFI
GRTDDIINS-----------------------------SGTSFCRY-RIGP-SEVENALM
EHPAVAETVVISSPDPT-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--ITGKI--------ER-AKL---RAKEWKTSG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWRRQL----QALCILW
RSQMS---NHTIRIH--TRQLASLQW---------G--HQ-EVPAKFNFATDVIDHWAGM
EKAGKRP-PGPALWWVSGNGDEVMW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FSQLSELSQQTANVFAGPCGLQRGDRVTVVLS
RVPEWWLVILGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQVSNARAIVAGDEVAEIV
DTVAPECPSLKTKLLVSE-KSRDGWLDFRTLLWK-ASTTHCFVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
---KWTDLQA---SDIIWPISD------------------------TAWIVNILGSLLEP
WTSGACTF-------------------------------IHLLPKFDPVIILKV----LS
SYPINYMIGAPL---VYRMLLL---QDLS-------------SYK----FPHLKCC----
----FSGGETLLPDTLEK--------WKIQTGLD---ILEFYGQTET-GLT---CRVSKT
MKIKPGYLGTA--IPHYDVQ------------VIDEKGNVLPPGTEGDVGI-RVKPIRPI
GIFSGYV-------------------DNIEKTEANIRGDFWVL--GDRAIKDQDGYFQFM
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPHFLSHDPDELTKELQQHVKSVTAPYKYPRK--IEFVL-DL--PK------T------
--NTGKV--------QR-AKL---RDKEWKKSEQVEV-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLHC----QRLRFIW
LAKPA---GRHFHRD--SQLWAPLTLDDFEAI-NRC--EK-PLPKNFNFAADVLDQWSLK

PF00501 // ENSGT00760000119178_4_Domain_0 (241, 849)

EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPSLKTKLLVSP-HHWDGWLNFQELLQS-ASEEHNCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQGSLGIGYTL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFDTDIFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKMQTGLE---LYEGYGQTEV-GII---CANRKG
EAIKPGSMGKG--VVPYDVQ------------IIDENGNILPSGKEGEIAL-RLKSDRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDDDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPYKCSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLKEL-----VLQALR
NARGI---CGSH-GQPPPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKAGHRP-PIPAFWWVDGTGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGEQSRKAANVLEGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GAIMI--PGISQLTEK-D--LKFRLQASRAKAIITSDSLAPRV
DAISADCPSLQTKLLVSD-SYRPGWMNFRELLWE-AATEHNCART---------------
------------------RGQDPVAIYFTSGTTGTPK-MVEHTQASYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRFDAKFILNT----LS
RFPITTLCCVPT---MFRLLVQ---EDLTRE-----------RYQ----FQSLRHC----
----VTGGEALTPDVREK--------WKSQTGLE---LHEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------VVDEEGNILPPGEEGNVAI-RVRPTRPF
CFFTCYL-------------------DNPEKTAASERGDFYIT--GDRAHMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEKLTQELQEHVKRVTAPYKYPRK--MAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWKN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AMKIFKL----PILKSLW
TQKPL---YRTFHGH--SKLLASDVYSQYQAV-RRG--EQ-EIPKYFNFASDVLDKWTEI
EKAGKRP-SNSAFWWISGKGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFLSRKVANVLTKVCGLQKGDRIIVVLP
RIPEWWLVNVACMRA--GIVLI--PGTTQLSAK-D--ILYRLQASKAKCIITDDTVAPAV
DSVASESQFLKNKLIVS-KGSREGWLNFSELYKN-QSADHSCAKT---------------
------------------RIEDSVNIFFTSGTTGSPK-MTEHSQGSLGFRPLL----SER
---YWLDLTP---SDVIWNIAD------------------------TGWILTSLTSVFDA
WVFGSCIF-------------------------------VHQLPQIESATILNT----LC
RFPIDTLVGVPT---LYRMLVQ---NDLS-------------SYK----FMNLKHC----
----MSGGEPLNPEVMEK--------WKSQTGLD---IHEVYGQTET-GII---CSVFKG
MKIKPGSMGKA--APLFDVQ------------VVDKNANILPPGQQGEIAV-RSKPIRPL
GLFSEYI-------------------DNPKKTAESERGDFYVT--GDRGTMDEDGYFWFI
GRDDDIIIS-----------------------------SG-----Y-RIGP-FEVESALM
EHPAVAEAAVVSSPDPL-RGE--------------------------------VVKAFVV
LSAAFSSSDREHLACELQEHVKKTTAPYKYPRK--VEFVQ-QM--PK------T------
--ITGKI--------KR-HEL---RNKEWGRM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LGIMKTW----LTFRFIW
LAKPS---GRHFHRD--HQRWASLTLADFEAI-NRC--DR-SLPKNFNFAGDVLDQWSQK
EKAGERP-ANPALWWVNGRGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGTLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLVNVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRVSKAKCIVASEEVAPAV
ESIVSECPHLKTKLLVSP-ESRNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGSVLPPGKEGEIAL-RVKSTRPF
CFFSEYV-------------------DNPEKTAATIRGHFYVT--GDRGVMDTDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNLEELTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
-------------------------------------------MENIRISPGPFSAQHSL
HPGAKFHSCVPRTEKDCAQTLQASSPSYSLPVSFTVSVDYLNMQWLRRF-------LTPL
GICKF---LHRFSLH--RPQLHRWLISGDGAQ-RWN--DY-DSPEEFNFASHVLDYWAQM
EGEGKRG-PGPALWWV

PF00501 // ENSGT00760000119178_4_Domain_0 (257, 848)

NDQGDEIKW--SFRELRDLSRRAANVFEQTCGLQHGDRLALILP
RVPEWWLVTVGCIRT--GVIFI--PGTAQMKAK-D--ILYRIQMSQAKAIVTTDSLVPEV
ESVASECPGLKTKIVVSD-HNHEGWLNFRTLLRS-ASPDHTCVKS---------------
------------------KMKDPMVIFFTSGTTGYPK-MAKHNQGL-AFRSSV---PSCR
---KFLKLKT---SDVIWCMSD------------------------PGWILATVGCLLEP
WTAGATVF-------------------------------VHNLPQFDPKVIVET----LF
KYPITQCLAAPA---VYRMVLQ---KNIS-------------NLR----FPTLEHC----
----ATGGESLLPEEYEQ--------WKQRTGLS---IHEVYGQSET-GIT---CAIFRE
MKVKRGSIGKA--ILPFDIQ------------IIDEKGNILPPNTEGYIGI-RIKPTRPL
GLFVGYE-------------------NSPEKTSEVECGDFYNS--GDRATIDEDGYIWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-TEVENALV
EHPAVSESAVVSSPDKD-RGE--------------------------------VVKAFIV
LNPXFLSHDQEQLIKELQEHVKSVTAPYKYPQE--GGVCF-RI--AQ------N------
--HHRQN--------QK-KGT---SK----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------MINIEKEDSEKDCSTMQRLMKF-------RVLW
GIHMS---CPGFHHA--PQHLRCQPLSGAGTL-RWN--EY-DRPEEFNFAGDVLDHWTQM
EKEGKRS-

PF00501 // ENSGT00760000119178_4_Domain_0 (249, 848)

ANPALWWVNDQGDEVKW--SFREMTDLTCRTANVFTQTCGLQTGDRLALILP
RVPEWWLVSVGCIRT--GIIFM--PGTTQMKAK-D--ILYRLQVSGAKAIVTTDTLAPEV
ESVAPECPSLKTKLLVSD-HSREGWLDFRSLIKS-ASPDHVCIKS---------------
------------------KTLDPMAIFFTSGTTGFPK-MAKHNHGF-ALRSYF---PACR
---KLLQLKA---SDVFWCLSD------------------------TGWILATLGSLLEP
WTAGSTVF-------------------------------AHHLPQFDSKVIIET----FF
KYPITQCLAAPS---VYRMILQ---QKST-------------SLR----FPALEHC----
----CTGGEALLPEEQEQ--------WKRQTGIL---LYQAYGQSET-GIT---CGTLRG
MKIKPGSMGKA--IPPFDIQ------------IIDDKGNIQPPNTEGNIGI-RIKPTRPI
GLFMYYE-------------------NNPEKTAEVECGDFYNT--GDRATIDEEGYFWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDPV-RGE--------------------------------VVKAFIV
LNPGFSCRDPDELTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KR-SEL---RKKEFGQK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QPFS---
LVR-SFRLGFGACCYPNQKCATQT-I-RAPDS-RCL--VQ-AVSQSFNFAKDVLDQWSQL
EKDGLRG-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 846)

KVSAKGEEDKW--SFERMTQLSEKAASILSDTCALSHGDRLMIILP
PTPEAYWICLACARL--GITFV--PGSPQLTAK-K--IRYQLRMSKAQCIVADEATAPVV
NSAMSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTYMRT---------------
------------------KSQDPMAIFFTKGTTGAPK-MVEYSQYGLGMGFSQ----ASR
---RWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVTED--------WKRITKLD---IYEGYGQTET-GLL---CATSKT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-RIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWWS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QPFS---
LVR-SFRLGFGACCYPNRKYATQT-I-RPPDS-RCL--VQ-AVSQNFNFAKDVLDQWSQL
EK----------------------------------------------------------
------------------I

PF00501 // ENSGT00760000119178_4_Domain_0 (320, 846)

TFV--PGSPQLTAK-K--IRYQLRMSKAQCIVADEAMAPVV
NSAVSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTYMRT---------------
------------------KSQDPMAIFFTKGTTGTPK-MVEYSQYGLGMGFSQ----ASR
---RWMDLQP---TNVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVIED--------WKRITKLD---IYEGYGQTET-GLL---CATSKT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-RIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWWS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------VKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGRQSRKAASVLERACGLQSGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQASRAKSIITTDALAPWV
DAISADCPSLQTKLLVSN-NSWPGWMNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQCTYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDTKVILNV----LT
RFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKQQTCLE---LHEGYGQSET-GVL---CANPKG
TRIKPGSMGKA--SPPYDVQ------------IVDDEGNILPPGEEGNVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPAYMSQDPEALTRELQDHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWKK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--EGKRG-PGPALWWVNGQGDEIKW--SF------

PF00501 // ENSGT00760000119178_4_Domain_0 (276, 848)

TRRAANVFEQTCGLQQGDRLALILP
RVPEWWLVTVGCFRT--GIVFM--PGTIQLKAK-D--ILYRLQRSQAKAIVTTGSLVPEV
DSVASECPALKTKLVVSD-HSHEGWLNFQSLIKS-VSPNHTCIKS---------------
------------------KMKDPLAIFFTSGTTGFPK-MAKHDQGL-AFRSCI---PSCR
---KVFGLKT---SDILWCMSD------------------------PGWILATVGCLIEP
WASGSTVF-------------------------------IHHLPQFDPNVIVEV----LF
KYPITQCLAAPA---VYRMILQ---QKIA-------------NLR----FPTVEHC----
----STGGESLLPEEYKQ--------WKQRTGLL---IHEVYGQSET-GIS---CAVFRE
MKIKIGSMGKP--VLPFNVQ------------IIDEKGNILPPNTEGYLGI-RIKPTRPL
GLFVEYE-------------------NDPQMTAEVECGDFYNS--GDKATVDDDGYIWFL
GRGDEIINA-----------------------------SG-----Y-RIGP-TEVENALA
EHPAVAESAVVSSPDPN-RGE--------------------------------VVKAFIV
LTPEFLSHDQEQLTKELQQHVKSVTAPYKYPRK--VEFVT-EL--PK------T------
--VTGKI--------RR-KEL---RMKEFSQR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MPSIFHRLRGMKS------------PHFPYYLSRQVCGTMRLKLIHL-----FLQPLW
GSQTL---SRPFRYISTRLLSPQKTFADFEAI-HQG--KQ-AIPEYFNFASDVLDMWSQM
EKAGKKS-PNPAFWWVSGQGEEVKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

YEELGIQSKKAANVLSRVCNLRPGDRLLVILP
RIPEWWLVSVACMRT--GVVII--PGISQLTIR-D--IQYRLQASGAKAIITNDSLAPHV
DTISADCPSLRTKVLVSS-SSRLGWLNFRELCRV-APEEHNCVKT---------------
------------------RSQDPLVIYFTSGTTSSPK-MLEHTQVSYGLGFAT----CAR
---KWTDLSD---SDIFWNTSD------------------------TGWVKAAWT-FYST
WIRGACLF-------------------------------IHQLPKADINVILNT----LC
QMPITTFCCVPT---MFQILVQ---HDLT-------------RYK----FKSLRHC----
----VTGGETLNPDVRKK--------WKSQTGLE---LHEGYGQSET-ALI---CANQKG
MKIKSGSMGKA--FPPYDVQ------------IVDDEGNILPPGKEGNIGI-RIKPKPPL
CLFTGYV-------------------DNAEKTASCKRGDFYIT--GDCAHMDEDGYFWFK
GRADDVINS-----------------------------AS-----Y-RIGP-FEVESALS
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LNPDFINQDPGELTRDLQEHVKRLTAPYKYPRK--VEFVQ-EL--PK------T------
--VSGKI--------QR-SKL---RKKEWKN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---GHRP-PNPAFWWVDGLGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 755)

SFEELGKLSRKAANVLRGVCGLQPGDRMMLVFP
RLPEWWLVSVACMRT--GVVLI--PGISQLTEK-D--LKYQLQVSRAKSIITSDSLAPWV
DTISTDCPSLQTKVLVSD-SSHPGWLNFRELLQA-ASTEHSCVRT---------------
------------------RSQDALSIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---QWVALSD---SDIMWNTTD------------------------TGWVKAAWT-LFSA
WPHGSCIF-------------------------------VHELPQVNAKVILNV----RD
KNTIDMLDSPAF---IHE--FA---SNWNIE-----------RYQ----FQSLKHC----
----LTEGEALNPDVREK--------WKSQTGLE---LHEGYGQSET-VVI---CANPKG
TKIKSGSMGKG--SPPYDVQ------------VCRLSQSPERPGLKRSETQ-AL------
-----WL-------------------A----TQARQVGGL--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRWLMKF-------RVLW
DIHRS---RCGFYPA--PQYLRFQCLSGPGAP-RWN--DY-DTPEEFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNNQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTRRAANVFTQTCGLQEGDHLALILP
RVPEWWLVIVACIRT--GIVFM--PGTTQMKAK-D--ILYRLQVSKAKGIVTTDTLAPEV
DSVASECPALKTKLLVSD-HSRKGWLDFRSLMRS-ESPVHTCIKS---------------
------------------KTLDPMAIFFTSGTTGFPK-MAKHSHGL-ALRSFF---PSCR
---KLLQLKT---SDVLWCLSD------------------------TGWILAVGGSLLEP
WTAGSTVF-------------------------------VHHLPQFDPKVIVQT----LF
KYPITQCFAAPS---VFRMILQ---QDST-------------SLR----FPTLEHC----
----CTGGEALLPEEQEL--------WRRQTGVL---LYQAYGQSET-GTT---CGTLRG
MKIKPGSLGKA--IPPYDIQ------------IIDDKGNILPPNTEGNIGI-RIKPTRPI
GIFMCYE-------------------SNPVKTAEVECGDFYNS--GDRATVDAEGYFWFL
GRADDVINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPNFLSHDRDQLTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KR-SEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLCLRGL-----VCQALR
SSWGV---CRIH-TQPPPPRIPE-VVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKTGHRP-PNPAFWWVNGSGTEVKW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGVSQLTAK-D--LKYRLQAARAKSIITSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRA-ASPEHNCVRT---------------
------------------RSGDSVAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTMCCVPT---LFRLLVQ---EDLT-------------RYK----FQCLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRD
STIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDEDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYASHDPEALTRELQEHVKTVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFHY----QTFRFIW
LTKPP---GWRLHKD--HQLWTPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANMLTKPCGLQRGGRVAVILP
RIPEWWLVNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIVLECPDLKTKLLVSP-QSRNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGFPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLD---LYEGYGQTEV-GMI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKPTRPF
CFFSKYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRGRQFDNKAEGLSSNMVAFF-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTISD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVDETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MEI-LRA----RCF-QCL
AIHSFMRPLHRDYRA----ATPQ-NFSSYESMKKDF--KL-EIPEYFNFAEDVLDQWTNV
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 318)

KVGKRP-SNPAFWWINGNGEEVRW--SFEELGWLSRKFANILTEACSLKKGDPVIVILP
KIPEWWLANVACLRT--G------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RVVW
AIHKS---CHSFHPA--PQHLRCRSVSGPEAP-KWD--DY-DTPEEFNFARDVLDYWTQM
EKEGKRH-PSPALWWVNSKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFTEMTDLTRRVANVFSQTCGLQQGDRVALVLP
RVPEWWLVTVGCIRT--GIIFM--PGTTLMTAK-D--ILYRLQKSEAKGIVTTDTFAPEV
DSVASECPSLITKLLVSD-HRREGWLDFWSLIKS-ASPDHTCIKS---------------
------------------KTMDPMAIFFTSGTTGFPK-MAKHSHGL-ALRSSL---PSCR
---KLLQLKT---SDIIWCLSD------------------------PGWIMAILGALLEP
WTAGATVF-------------------------------IHHLPQFDPKIIVQM----FF
KYPITQCLGAPT---IYRMIMQ---QNFT-------------SLK----FPALEHC----
----STGGEALLPEELEK--------WKKLTGIL---IHEAYGQSET-GIL---CGVLRG
MKIKPGSLGKA--ISPFDVQ------------IIDENGNILPPNTEGNIGI-RIKPTRPT
GLFMCYE-------------------KDPENTAQVECGDFYNT--GDRATIDEEGYFWFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSNDQGQLTKELQQHVKVVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-KEL---REKEFELM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRRL-----VLQALR
SSRGF---CGSR-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHNVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEVKW--SFEELGKQSRKAANVLAGACGLQPGDRMMLVLP
RIPEWWLVSVACMRT--GAVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSIAPRV
DAINAECPSLQTKLLVSE-SSRPGWLNFRELLRE-ASPEHTCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHS----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CDNPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LTPAYLSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------GLVFM--PGTTQLTAK-D--ILYRLRASKAKCIVVSEEVVPAV
ESIVSECPDLKTKLLVSP-RSQNGWPSFQELFQS-ASAEHSCVET---------------
------------------GSQEPTAIYFTSGTTGSPK-MAQHSQSSLGTGYTL----CGR
---YWLDLKS---SDVINNMSN------------------------TGWVKATIGSVFSS
WLQGACVF-------------------------------VHWMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLKTS-------------T----SHSTSHD----
----NQKWNKIVPQFKNN--------KEQLGATE---HFPGDNQSPT-MLI---NGVALY
IYVTHMNSTHE--KRKKENQ------------LNDAASPILFPGGRDQIGT-FSYPSQYL
PLLAPLL------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (806, 910)

-DNPEKTAATIRGNFYVP--GDRREMDSDRHFWFV
GRADDVIMS-----------------------------SW-----FVLIGP-FEVQSALT
EHLAVVEAAVVSSPDPM-KGE--------------------------------EVKDLIA
LSAPFKSSNPGKLTLELQDHVKK-TVPYKYPRK--ASILPKKF--PE------T------
--ITGKT--------KR-NVL---RDHKWGQT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RTLW
GIHKS---FHNIHPA--PSQLRCRSLSEVGAP-RWN--DY-EVLEEFNFASYVLDYWAQM
EKEGKRG-PNPAFWWVNGQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 315)

SFREMGDLTRRVASVFTQTCGLQQGDHLALILP
RVPEWWLVAVGCMRT--DQHPK--NTPVL-------------------------------
--------------------SQRPWTQWSSSS-----P----------------------
--------------------V---------GPQ---------------------------
-------------ASPRWQNTP------------------------MGWPYNPP------
------------------------------------------------------------
--------------------SQ---EDIV---------------E----IPHQ-PL----
----CRGTTC-----------------------I---SNDSAAGFHQ-GAI---CATFPG
MKFKPGFMGKA--AAPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFKCYE-------------------GDPEKTAEVECGDFYNT--GDRGKMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSHDKDQLIKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KW-NEL---RKKEIGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------PISTCTGCLMKS-----GSCVLRL
LSRSP---CRLFHGC--NRLLTSQVISYYDSV-NRC--EK-ELPEYFNFASDVLDKWSQL
EKDGKRP-ANPAFWWVNDEGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFLSRKTANILSEACGLQRGDRMIAVLP
RVPEWWLLNVACMRT--GIVFI--PGTSQLTAK-D--ILYRLQASKAKCIVTSDALAPAV
ESVMSECHFLKTKLIVAK-GSRDGWLNLKELFVV-TSADHKCVKT---------------
------------------RSQDPMLIYFTSGSTGSPK-MVVQSHGSYGIGFAT----SGR
---YWMNLTP---SDIMWNTSD------------------------TGWVKAAWSSVFAP
WINGSCVF-------------------------------VHSLPEFKPAVIAET----LS
RYPITTFCTAPT---AYRMLVQ---HCLS-------------SYK----FMSLKHC----
----LSGGEALNPEVMEQ--------WKIQTGLD---IYEGYGQTET-VTI---CANMKG
MKIKPGSLGKA--VPPYDVQ------------IIDDHGTVVPVGKEGNIAI-RVQPERPF
CMFSEYL-------------------DNPEKTAACMSGNFYVT--GDRGIMDEEGYVWFV
GRSDDIINS-----------------------------SG-----Y-RIGP-FEVESALI
QHPAVMESAVVSSPDPV-RGE--------------------------------VVKAFVV
LAPAFVSHDPEKLTQDLQQHVKKVTAPYKYPRK--VEFVQ-AL--PK------T------
--ATGKI--------QR-KVL---RNKEWEKA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWTPLTLADFEAI-NRC--NR-PLPENFNFAADVLDQWAQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
ESIALECPDLKTKLLVSP-QSRTGWLSFQELFQF-ASEEHSCVET---------------
------------------RSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MMPWLRGR-----VLKVLR
SARGF---CGPH-GQPPPLLDPQDIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDMWSQL
EKAGHRP-PIPAFWWVNGTGAEVKW--NFEQLGQQSRRAANVLKDTCSLQPGDRMMLVLP
RLPEWWLVSVACIRT--GAVMI--PGVSQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISADCPSLQTKLLVSD-NSRPGWMNFRELLRE-ASTEHNCVRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQASYGLGFVA-----S-
-GRHWVDLTK---SDIFWNTSD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
SFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQVGLE---LHEGYGQSET-VVI---CANSKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNILSPGEEGNVAV-RVRPARPF
CFFSCYL-------------------DNPEKTEASERGDFYIT--GDRAHKDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLEAAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPTYSSQDPEKLTRELQEHVKRVTAPYKYPRK--VTFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGETRGSPRKAP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQCLMKF-------RVLW
SIHKF---FHTFRPA--PPQLRCQSLSRVRAP-TWN--EH-NVPKEFNFASDVVDYWAQM
EKEGKRG-PEPALWWINTQGDEVKW--NFRELRDLSCRVANILTQTCGLKKGDYLTLILP
RVPEWWLVAIGCIRT--GIIFL--PGTTQLKSK-D--ILYRLRMSNSQAIVTTDTLAPEV
DSVASECPALKTKLLVSE-HTLNGWLDLRSLIKS-ASPEHTCIKS---------------
------------------KTEDPMTIFFTSGTTGFPK-MAKHSQGL-ALRSYL---PACR
---KLMQLKT---SDILWCVSD------------------------PGWILAAVGGLFEP
WTAGSTLF-------------------------------IHHLPQFDPKIIIKV----LF
KYPITYCLAAPG---VYRMILQ---QKEA-------------NLR----FPTLKHC----
----YTGGESLLAEEFEQ--------WKKHTGTL---LREIYGQSET-GIT---CGVLQE
MKVKPGSLGKA--ISPFDIQ------------IIDNQGNVLPPNTEGNIGI-RIKPTRPV
GLFMYYE-------------------NNPEKTAEVECGDFYNS--GDKATIDSEGYIWFL
GRNDDVINA-----------------------------SG-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPA-RGE--------------------------------VVKAFIV
LNPPYRSHDQDQLTKELQQHVKSVTAPYKYPRK--VEFVL-EL--PK------T------
--VTGKI--------KR-SEL---RKKEFAQRQ---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGP-----DLRAPR
SSWEF---CRVY-TQLSPLPAPQKILAGWEAI-SLG--RQ-PVPEYFNFAHDVLDMWAQ

PF00501 // ENSGT00760000119178_4_Domain_0 (240, 849)

Q
EKAGHRP-SSPAFWWVDGKGAEVKW--SFDELGMQSRKAANILEKVCSLKPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQVSRAKSIITSDSLAPHV
DAISAECPSLQAKLLVSD-ASRPGWMNFRELLQE-ASTEHSCVRT---------------
------------------KSGDPMSIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGS
---RWMGLTG---SDIFWNTTD------------------------TGWVKAAWS-LFPT
WAIGSCLF-------------------------------VHEMPRVDTKVILNT----LS
RFPITNFCCVPT---IFRLLVQ---EDLT-------------RYQ----FRSLRHC----
----LTGGEALNPDVREK--------WKCHTGLE---LHEGYGQSET-VPI---CANARG
TKIKSGSMGRA--SPPYDVQ------------IVDDEGNVLPPGEAGNIAV-RIRPTRPF
CFFHCYL-------------------DNPEKTAASEQGDFYIT--GDRGRMDTDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVASSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RKQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------VA

PF00501 // ENSGT00760000119178_4_Domain_0 (353, 849)

DDAAAPAV
DSVESRCPSLKTKLLVSD-DNRGGWLNFPKLIHS-APADHRCVRT---------------
------------------KSRDAMAIYFTSGTAGAPK-MVEHSHYSLGMGFSL----AAR
---RWMALEP---ADVVWGLGDAS-----------------------GADPFSLSSALGA
WLQGACLF-------------------------------LHHMPKISSETVLDA----LS
RFPITTFYGRPS---LYQRLLQ---DCNFSS------------YR----FQSLKHC----
----VAAGEPSKPWVNRE--------WKRLSHLD---IYEGYGQTET-GLI---CATYKR
MKVKPGSLGKP--VLPYNVQ------------IVDENLNILPPGEEGNIAV-QTQPNRPF
SLFSRYV-------------------DNLEPTALAEPRRFYLT--GDKGVMDEEGYFWFA
GRADDIINA-----------------------------SD-----V-KL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWRRQL----QALCILW
RSQMS---NHTIRIH--TRQLASLQW---------G--HQ-EVPAKFNFATDVIDHWAGM
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGKRP-PGPALWWVSGNGDEVMW--NFSQLSELSQQTANVFAGPCGLQRGDRVTVVLP
RVPEWWLVILGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQVSNARAIVAGDEVAEIV
DTVALECPSLKTKLLVSE-KSRDGWLDFKTLLWK-ASTTHCFVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
---KWTDLQA---SDIIWPISD------------------------TAWIVNILGSLLEP
WTSGACTF-------------------------------IHLLPKFDPVIILKV----LS
SYPINYLIGAPI---VYRMLLL---QDLS-------------SYK----FPHLKCC----
----FSGGETLLPDTLEK--------WKIQTGLD---ILEFYGQTET-GLT---CRVSKT
MKIKPGYLGTA--IPHYDVQ------------AIDEKGNVLPPGTEGDVGI-RVKPIRPI
GIFSGYV-------------------DNIEKTEANIRGDFWVL--GDRAIKDQDGYFRFM
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPHFLSHDPDELTKELQQHVKSVTAPYKYPRK--IEFVL-DL--PK------T------
--NTGKI--------QR-AKL---RDKEWKKSESFAEE----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKI----PRYCTLW
GTQMS---IRTFQIN--SKKLTPIPW---------G--NQKEVPAKFNFASDVIDHWANM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-SRPALWWVSGSGEELKW--NFRELSELSQQAANVLSGACGLQRGDRVAVVLS
QVPEWWLVTLGCIRT--GLVFM--PGTIQMKST-D--ILYRLQSSNARAIVAGDEVAQEV
DTVAPDCPFLKVKLLVSE-KRREGWLNFKTLLKD-ASSTHHCVET---------------
------------------GSHEPAAIYFTSGTSGPPK-MAEHSHSSLGIKAKM--DAD--
---SWTGMDV---SDTVWTISD------------------------TGWIVNIIAAFLEP
WTLGACTF-------------------------------IYFLPKFDPKTVLKV----LS
SYPINSMVGAPL---IYRMLVQ---QDLS-------------SYK----FPHLHSC----
----FTGGESLLSETLEN--------WKAKTGLD---IREFYGQTET-SKTVSPCQLCRH
TAVRVASLQWVIHPIFLFLQ------------VIDEHGNVLPPGKEGDIAI-RVKPIRPV
GIFSGYV-------------------NNPKKTEANIRGDFWLL--GDRGIKDPEGYFYFL
ARTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVAETAVVSSPDPS-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRK--VEFVS-NL--PK------T------
--ITGKI--------NR-AKL---RTEEWKTSRQGQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFIQV----QTLKFLW
SPKPR---GRWFHRD--TRTWAPLSFADCEAI-NRC--EQ-ELPEHFNFAGDVLDRWAHL
EKSGERS-ASPALWWVNGKGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

TFKEIGILSRKVANVLSKPCGLQRGDRVAVILP
RIPEWWLVNVACMRT--GLVFM--PGTTQLTAK-D--IQYRLQVSKAKCVVTSDAVAPAV
DSIVAECPALETKLLVSG-TQREGWLNYGELFKS-ASTEHSCVKT---------------
------------------GSRDPMAIYFTSGTTGAPK-MAQHSQSSLGIGFTL----CGR
---YWLDLRP---SDIIWNMAD------------------------TGWIKAAIGSVL-S
WLQGACVF-------------------------------VHSMDQFDVETFLDT----LT
SFPITTLCSAPT---VFRMLVQ---KDLK-------------SYK----FKSLRHC----
----LTGGEPLNPEVWEQ--------WKNQTGLE---LYEGYGQTEV-GII---CANQKG
MEIKPGSMGLG--VAPYDVQ------------IIDENCNILPAGKEGDIAL-RVETTRPF
CFFSDYV-------------------DNPEKTAATMRGRFYIT--GDRGVMDKDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVEVAVVSSPDPI-RGE--------------------------------VVKAFVV
LSEPFKSSNTEKLTLELQNHVKRVTAPYKYPRK--VEFVT-EL--PK------T------
--ITGKI--------QR-NIL---RKQEWVLSGRTRST----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWMPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWAQK
EKTGEIP

PF00501 // ENSGT00760000119178_4_Domain_0 (248, 849)

-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFI--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
EPIALECPDLKTKLLVSP-QSRTGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRTQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTWPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMKF-------RVLW
GIHKS---CHGFLPA--PRHLRCQFLSGAEAP-RWN--DH-DTPEEFNFASGVLDYWTQM
EKEGKRG-PNPALWWVNDQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTRRAANVFTQTGGLRQGDHLALILP
RVPEWWLVTVGCIRT--GIVFT--PGTTLMKAK-D--ILYRLQVSKAKGIITTDTLAPEV
DSVASECPALKIKFLVSD-HSREGWLDFRSLIKS-ASSDHTCVKS---------------
------------------KTMDPMAIFFTSGTSGLPK-MAKHNQGL-ALRSSF---PSCR
---KLLQLKT---SDVFWCLSD------------------------PGWILAVLASMFEA
WTAGSTVF-------------------------------IHHLPRFDPNVIVQT----LS
KYPITQCLAAPS---VFRMILQ---QDFT-------------SLR----FPTLEHT----
----CAGGEALLPEEQEQ--------WRRQTGVL---LYQVYGQSET-GIT---CGILRG
MKIKPGSMGKA--IPPFDVQ------------IIDDKGDVLPPNTEGNIGI-RIKPTKPI
GLFMCYQ-------------------DDPVKTAETECGDFYNT--GDRATMDAEGYIWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-AEVESALA
EHPAVAESAVVSSPDLI-RGE--------------------------------VVKAFVV
LTPQFLSRDRDQLTKELQEHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-NEL---RKKEFGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-ILLHY----QRFRFIW
LANPA---SRHFHRH--PQLRTPLTLADFEAI-NRC--EK-PLPKNFNFAADVLDQWSQK
EKSGERP-ANPALWWVNGEGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTRK-D--ILYRLQASKAKCVVASEEVAPAV
DSIASECPNLKTKLLVSP-NHWDGWLNFQELLQL-ASEEHSCVET---------------
------------------RSQEPMAIYFTSGTTGPPK-MAQHSQSSLGIGYAL----CGR
---YWMDLTP---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLQGACVF-------------------------------VHRMAQFDTDTFLDV----LT
TYPVTTLCSAPT---VYRMLVQ---KDLK-------------RYR----FKRLQHC----
----LTGGEPLNPEVLEQ--------WKLQTGLE---LYEGYGQTEV-GII---CANCKG
QEIKPGSMGKG--VVPYDVQ------------IIDENGNVLPPGKEGEIAL-RLGSTRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPFKSSNREKLIAELQDHVKNSTAAYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLTRF-------RVFG
AIHKS---SHGFHPA--PWPLRCQSSSDAGAA-RWN--DH-DVPEEFNFASCVLDYWAQM
EKEGKRS-ANPAFWWVNSQGEELKW--SFQEMAELTRRAANVFTQTCGLQQGDHLALILP
QVPEWWLATVGCIRA--GIIIM--PGTIQLKAK-D--ILYRLQASKAKAIMTTDTLAPEV
DSVAPECPTLKTKLLVSD-HRRHGWLDFRSLMKS-ACPDHTCVKS---------------
------------------KTMDPMVIFFTSGTTGLPK-MAKHSHGL-ALRASL---PSCR
---KLLDLKM---SDVFWCLSD------------------------PGWIMSFSGSLIEP
WTAGSTVF-------------------------------IHHVPQVDPKVIVQA----LF
KYPITQLLGVPS---IFRMILQ---QNFA-------------SLR----FPTLEYC----
----YTGGEAQLPEELEE--------WKRRTGLL---LCGIYGQSET-GPA---CGTLRE
TKIKLGSTGKA--LSPYDIQ------------IIDDQGNVLPPNTEGNMGI-RIKPTRPV
GIFLCYE-------------------GDPEKTAEVECGDFYKT--GDRATMDAEGYIWFL
GRDDDIINA-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAAVSSPDPT-RGE--------------------------------VVKAFIV
LTPQFLSHDRAQLTRELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------RR-SEL---RRKEFGLM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKL----QGLCTLW
STQMS---SRTPHIM--TRQLASVQW---------G--RQ-EVPATFNFARDAIDHWADM
EMAGKRP-PGPALWWVSGKGEEVKW--NYRELSEITRQVANVLLGPCGLQRGDCVAVVLP
RVPAWWLVILGCMRA--GLIFT--PGTIQLKSA-D--ILYRLQLSKAKVIVAGDEVAQEV
DMLAPKCPSLRMKLLVSE-KNQDGWLNFNTLLKE-ASTTHRCVET---------------
------------------GSQEAVAFYFTSGTSGPPK-MVEHSHASLGLKSKM--DAG--
----WTDLQP---SDILWTISD------------------------TAWILNLIGALLEP
WTSGACAF-------------------------------IHHLPKFDPAVILKV----LS
SYPVNNLIGAPI---VFRMLLQ---QDLS-------------SYK----FPHLKHC----
----FSGGESVLPEILEN--------WKATTGLD---IREFYGQTET-VLT---CRVSTT
MKIKPGCMGTP--IPNYDMQ------------VIDNEGNVLPPGTEGDLGI-RVKPIKPV
GIFSGYV-------------------NDPQKVADNIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINA-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVVSSPDPV-RGE--------------------------------VVKAFVV
LAPEFLSHDRDQLTKELQQHVKSVTAPYKYPRK--MEFVS-DL--PK------T------
--ITGKI--------ER-AKL---RKKEWKMSGQDQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LGLWLRL----AHLLL-K
PVWGSQAFYRPLRYVSTGLPSTQKTFADFEAI-HLG--KQ-AIPEYFNFASDVLDMWSQM
EKAGKRS-PNPAFWWIDGQGAEIKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 392)

TYEELGIQSRKTANVLSRVCNLRPGDRLLLILP
RIPEWWLVNVACMRT--GVVII--PGVSQLTKK-D--IQYRLQASAAKAIITNDSLAPQV
DTISADCPSLRTKVLVSG-SRRPGWLNFRELCXX-XXXXXXXXXX---------------
------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX----XXX
---KW--IDLS-DSAIFWNTSD------------------------TGWVKAAW-TFYST
WIAGACLF-------------------------------I---HQLP-------------
---------------------K---A-DTNV------------IL----N----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLRCQSLSEIGAP-RWN--DY-EVPEEFNFASYVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--NFREVADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTVDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFYGAPS---IFRMILQ---EDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--DGFKG-PYPALWEVGA

PF00501 // ENSGT00760000119178_4_Domain_0 (259, 707)

KGEEDRW--GFERMARLSQKAASILSDTCALSRGDRLMIILP
PTPETYWICLACMQL--GITFI--PGSPQLPAK-E--ICCRLRMSKAQCVVSGEVMAPVV
DSVMFNCPTLKTKLLVSD-KSYDGWLDFKELFQV-APPRKTCVRT---------------
------------------DSQDPMAIFFTNRKMGTPK-LVEYSQYGLGMGFSQ----ASR
---QWMDLQP---TDVLWSLGDAF-----------------------GG-TLSLSTAFGA
WLQGACVF-------------------------------LHHMPTFCPETVLNA----LS
RFPITTLSGNPW---MYQKLLQ---HKYFTS------------YR----FKSLKHC----
----VAAGGSISPGVTEA--------WNRITKLD---IYEGYGQTET-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWRRGL-----VLQALR
SSWGV---CRIH-RQPPPPPVPE-VVATWEAI-SLG--RQ-PVPEYFNFAHNVLDEWSRL
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGNRP-PNPAFWWVNGSGAEVKW--TFEELGKQSRKAANVLEGVCGLKPGDRMMLVLP
RLPDWWLSCVACMRT--GVVMI--PGVSQLTAK-D--LRYRLQAARAKSIITSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRE-ASTEHNCVRT---------------
------------------KSRDPVAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRADAKTILNT----LC
KFPITTLCCVPT---LFRLLVQ---EDLT-------------RYK----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VLI---CGNSRD
STIKSGSMGKA--SPPYDVQ------------IVDEDGNVLPPEKEGNVAV-RIKPTRPF
CFFNSYL-------------------DNPEKTASSEKGDFYIT--GDRAHMDKDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYTSHDPEALTRELQEHVKKVTAPYKYPRK--VAFIS-EL--PK------T------
--ISGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKIFF-RY----QTFRFIW
LTKPI---GRRFHKS--HQLGAPLTLADFEAI-NRC--ER-SLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFGELGSLSRKAANVLTKPCGLERGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTAK-D--ILYRLHASKAKCIVASEEVIPAV
ESIVSECPDLKTKLLVSP-HSQDGWLSFPELFQT-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---TDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIAL-RLTSTRPF
CFFSEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVK-EL--PK------T------
--ITGKI--------KR-NVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPRLKGL-----ILQALK
SFRGV---CTAH-GQLPPPPVHQ-AVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKAGHRP-TNPAFWWVNDTGAEVKW--TFGELGHQSRKAANILVGVCDLQPGDRMMLVLP
RLPEWWLLSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIVTSDSLAPQV
DAISADCPALQTKLLVSD-RSRPGWLNFRELMLK-ASSEHKCMRT---------------
------------------KSSDKLVIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACVF-------------------------------VHELPRADAKAILNI----LC
KFPITTFCCVPT---IFRMIVQ---EDLT-------------RYR----FQSLKHC----
----ITGGEALNPDVRDK--------WKCQTGLE---LHEGYGQSET-VVI---CANPKG
SAIKSGSMGRA--SPPYDVQ------------IVDDEGNILPPGEEGSVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASERGDFYIT--GDRARMDKDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESVLA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPEYSSHDPEALTRTLQEHVKQMTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SIL---RKQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRCR-----VLQALK
SSRGF---CGSH-GHLSPLPAPQKIVRTWEAI-SLG--RQ-PVPEHFNFAHDVLDVWSQL
EKAGHRP-PNPAFWWVDGKGKEVKW--SFEELGHWSRKAANILASACGLQPGDRMMLVLP
RLPEWWLASVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQTSRAKSIITSDALAPQV
DAISADCPSLRVKLLVSD-SGRPGWMNFRELLRE-ASAEHKCVQT---------------
------------------KSRDALAIYFTSGTTGNPK-MVEHSQGSYGLGFVA----SGR
---QWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGSCIF-------------------------------VHELPRVNAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLTR-------------YQ----FHSLRHC----
----LTGGEALNPDVREK--------WKNQTGLE---LYEGYGQSET-VVI---CANPRG
STIKAGSMGKA--SPPYDVQ------------IVDDEGHILPPGEEGNIAV-RVRPTRPF
CFFNCYL-------------------ENPEKTAASERGDFYIT--GDRAHMDKDGYFWFM
GRSDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPT-RGE--------------------------------VVKAFIV
LSPTYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SSRY

PF00501 // ENSGT00760000119178_4_Domain_2 (887, 910)

-RIAL-AEVENALA
EHPEVAELAVASSLDPI-PGE--------------------------------GVKVFIV
MSPQFLSHDQDQLTKEPQQHVKGVTAPYKHPRN--AEFVP-EL--PK------T------
--IIAKF--------KQ-SEL---QKRSLGGCNRQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
NSRAF---CGSH-GKPAPLPVPQKIVATWEAI-SLG--RQ-LVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GTVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSD-SSRPGWLNFRELLRE-ASTEHNCMRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
KFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKHQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTKKIIW
LTKPP---GRHFHKD--RQKKTPLTLADLEAI-NRC--NR-QKNKNFNFAADVLDQWAQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVKKIRT--GIVFI--PGTIQLTAK-D--ILYRLRASKAKCVVASKKMAPVV
ESIALECPDLKTKKLVSP-QSRTGWLSFQE---F-ASEEKKCVET---------------
------------------GSQEPMTIYFTSEKKGSPK-MAQHSQSSLGIGKKI----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHQMAEFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KKKK-------------RYK----FKSLRHC----
----LTGGEPLKKEVLEQ--------WRTQTGLE---LYEEKKQTEV-GII---CAKKKG
QEIKPGSMGKG--MLPYKKK------------IIDENEKNLPPGKEGEIAL-RLKSTWPF
CFFSEYV-------------------DNPQKTAKKIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----K-QLHS------ALA
---------------AN-PKK--------------------------------VVKAFVV
LAAPFKSYNPEKLKKKLQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKK--------KN-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWRKSF-------Q---
-ICKV---LQGFSLS--PTQLHRRLFSRVGAP-RWN--DH-DSPEEFNFASDVLDYWAQM
EEEGKRG-PNPAFWWVNGQGDEIKW--SFRKLRDLTCRTANVFQQICGLQQGDHLALILP
RVPEWWLVTVGCIRT--GIIFM--PGTTQLKAK-D--ILYRIQMSRAKAIVTTASLVPEV
ESVASECPDLKTKLVVSD-HSHEGWLDFWSLIKS-ASPDHTCIKS---------------
------------------KMKDPMAIFFTSGTTGYPK-MAKHNQGL-AFRSYM---PSCR
---KLLKLKT---SDILWCMSD------------------------PGWILATLGCLIEP
WTSGCTVF-------------------------------IHHLLQFDPKVIVEV----LF
KYPITQCLAAPG---VYRMVLQ---QKTS-------------NLR----FPTLEHC----
----TTGGESLLPEEYEQ--------WKQRTGLS---IHEVYGQSET-------------
--------------------------------IIDEKGNILPPNTEGYIGI-RIKPTRPL
GLFMEYE-------------------NSPENTSEVECGDFYNS--GDRATIDEEGYIWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1025)

EVENALV
EHPAVAESAVVSSPDKD-RGE--------------------------------VVKAFIV
LNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--VTG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------LIPWXKGQ-----LLQALR
SARGL---CGTP-VQPPPFPGPQKAVATWEAI-SLG--RQ-PVPEYFNFAHDILDVWSQL
EKAGHRP-PNPAFWWVDGLGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGKLSRKAANVLRGVCGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVLI--PGVSQLTEK-D--LKYRLQVSRAKSIITSDSLAPRV
DTISTDCPSLQTKVLVSD-SSRPGWLNFRELLRA-ASTEHSCVRT---------------
------------------RSQDTLSIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---QWVALSD---SDIMWNTTD------------------------TGWVKAAWT-LFSA
WPHGSCIF-------------------------------VHELPQVNAKVILNT----LS
RFPITTLCCVPT---IFRLLVQ---EDLTRE-----------RYQ----FQSLKHC----
----LTGGEALNPDVREK--------WKSQTGLE---LHEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGTIAI-RIRPARPF
CFFNCYL-------------------DNPEKTAAAERGSFYVT--GDRARMDKDGYFWFV
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPV-RGE--------------------------------VVKAFIV
LSPAYLSHDPEELTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------PLTLADFEAT-NRC--NR-PLPKNFNFAADVLDQWSQK
EKIGERS-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGTLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLVNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVAGEEVAAAV
ESIALECPDLKTKLLVSP-QSRNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGFPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGCVFSS
WLYGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLQHC----
----LTGGEPLNPEVLEQ--------WRVQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGKVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LATPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RTLW
GIHKS---FHNIHPA--PSQLRCRSLSEFGAP-RWN--DY-EVPEEFNFASYVLDYWAQM
EKEGKRG-PNPAFWWVNGQGDEIKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMGVLTRRVANVFTQTCGLQQGDHLALILP
RVPEWWLVAVGCMRT--GIIFI--PATILLKAK-D--ILYRLQMSKAKGIVTIDTLASEV
DSISSECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTLDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PGRR
---KLWSLKT---SDVCWCLSD------------------------SGWIVATIWTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIVQT----LL
KYPINHFWGVSS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTSGEVMFPKDQEE--------WKRRTGLL---LYENYGQSET-GLI---CATFPG
MKIKPGFMGKA--TPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFKCYE-------------------GDPEKTAEVECGDFYNT--GDRGKMDEEGYICFL
GRNDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSHDKDQLIKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KR-NEL---RKKEIGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRS----QTFRFIW
LTKPP---GRHLHKH--HQLWTPLTLADFEAI-HRC--ER-LLPKKFNFAADVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GKRP-VNPALWWVNGKGDEVKW--SFRELSSLSQKAANVLTKPCGLQRGDRVAVILP
RIPEWWLLNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
ESIALQCPDLKTKLLVSS-QSRNGWLSFQELFQL-ASEEHSCVET---------------
------------------GSGEPMAIYFTSGTTGSPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFSS
WLHGACVF-------------------------------VHQMARFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKILRHC----
----STGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTWPF
CFFSEYV-------------------DNPEKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRFWRRGL-----VLQALK
SSWGI---CRIH-RQPPPPPVPK-VVATWEAI-SLG--KQ-PVPEYFNFAHDVLDEWSRL
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGSGAEVKW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPDWWLISVACIRT--GVVMI--PGVSQLTSK-D--LKYRLLASRAKSIITSDALAPKV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRE-ASAEHNCVRT---------------
------------------KSQDSLAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTMCCVPT---LFRLLVQ---EDLT-------------RYK----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRG
STIKSGSMGKA--SPPYDVQ------------IVDEEGNILPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------ENPEKTASSEKGDFYIT--GDQAHKDKDGYFWFS
GRNDDVIN

ENSGT00760000119178_4_Linker_0_2 (849, 894)

S-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_2 (894, 921)

EVESALA
EHPAVLECAVVSSPDPI-RGE---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLLLAGR----RLLKALR
TSRCS---FRSF-RLRCAGLAPQKIFSAFEAM-SLG--QR-EVPEYFNFAHDVLDVWCQI
EKNGKRP-PNPAFWWINGQGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGALSRKAANVLTEASGLERGDRMLVVLP
RIPEWWLVNVACMRT--GVVII--PGTSQLTAR-D--IAYRLQASQAKAIVTSDSLAAQV
DIVSAKCPSLKTKLLVSD-DSRPGWLNFRELVTV-ASTEHKHVKT---------------
------------------KSQDLAAIYFTSGSTGVPK-MVAHCQQSFGLGFAA----SGR
---LWVDLSP---SDIFWSMSD------------------------PGWVKAAWTNVFCP
WIHGSCVF-------------------------------VHQMPQFDSKLVLNT----LS
SFPITTFCMTST---GFRLLIQ---QDLA-------------SYQ----FKSLRHC----
----VTGGEPLNPEVRKQ--------WKSQTGLE---LYEGYGQTET-VLV---CSNNKA
MKIKSGSMGKA--TPPYDVQ------------IVDENGEILPPGEEGDIAI-RIKPTRPF
CFFSGYL-------------------DNPEKTKSTQRGNFYVT--GDRGRMDGEGYFWFL
GRADDVINS-----------------------------AG-----Y-RIGP-FEVESALM
EHPAVVESAVVSSPDPI-RGE--------------------------------AVKAYVV
LAPAFISQDPAELSRELQDHVKQVTAPYKYPRK--VEFVR-EL--PK------T------
--VSGKI--------QR-NKL---RIKEWGDQPRK-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLIRF-------QVLR
TIYKS---SYGFHSA--PWQLRYQSSSKTGAA-RWN--DH-DVPEEFNFASCVLDYWAQM
EKEGKIG-PNPAFWWVNRQGEELKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 886)

TFREITDLTCRVANIFKQTCGLQQGDRLALILP
QVPEWWLATVGCIRT--GIIFI--PGTIQLKAK-D--ILYRLQVSKAKGIMTTETLAPDV
DSVASECPALKTKILVSD-HRQNGWLDFRSLMRS-ASPDHTCFKS---------------
------------------KTMDPMVIFFTSGTTGLPR-MATHCHGF-ALRSSF---PSCR
---KLLNLKT---SDVIWCLSD------------------------PGWILSFFGSLIEP
WTAGSTVF-------------------------------IHYLPHFDPKVTVQA----LF
KYPITHFLGVPS---IFRMILK---QNFT-------------SLR----FPTLEHC----
----LTSGESQLPEEHKE--------WKRQTGLL---LYDVYGQKET-GPI---CGVSRG
MKIKPGSAGKA--MPPYDVQ------------IIDDKGNILPPNTEGSVGI-RIKPTRPT
GIFKCYE-------------------GDPEKTAEVECGDFYNT--GDKATIDTDGYIWIK
GRNDDIINA-----------------------------SG-----Y-LKVQ-AQNKNSFN
EHLHFKLSLRVA---AR-VLQ--------------------------------VVKAFIV
LSPQFLSHDRDQLTKELQEHVKMATAPYKYPRK--VEFVL-EL--PK------T------
--ITGKI--------KR-SEL---RRKEFGLM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
NSRAF---CGSR-RQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EEAGHRP-PNPAFWWVSGTGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GTVMI--PGVTQLTKK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSD-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLAVYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDVFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
TFPVTTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTSVE---LYEGYGQSET-VVI---CANPKG
TKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYFSHDPEVLMRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTHYIN--SRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNEKGKELMW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FRELSENSQQAANVLSRACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKSS-D--ILYRLQMSKAKAIVAGDEVIQEM
DTVASECPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGTIMET
WTVGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKNMMSAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CLVSKT
IKIKPGYMGRA--ASCYDVQ------------VIDDKGNILPPGTEGDIGI-RVKPTRPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-AKL---RDKEWKISRKARVQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLHC----QRLRFIW
LAKPA---GRHFHRD--SHLWAPLTLDDFEAI-NRC--EK-PLPKNFNFAADVLDQWSLK

PF00501 // ENSGT00760000119178_4_Domain_0 (241, 849)

EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPSLKTKLLVSP-NHWDGWLNFQELLQS-ASEEHNCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQGSLGIGYTL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFDTDIFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKMQTGLE---LYEGYGQTEV-GII---CANRKG
EAIKPGSMGKG--VVPYDVQ------------IIDENGNILPSGKEGEIAL-RLKSDRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDDDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPYKCSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MMPWLRGW-----VLQVLR
NARGF---CGPH-RQQPPLPDPQKIVATWEAI-TLG--RQ-PVPEYFNFAHDVLDMWSQL
EKAGHRP-RIPAFWWVNGKGAEIKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFEELGEQSRKAANVLQGMCGLQPGDRMMLVLP
RLPEWWLVSVACIRT--GAVMI--PGVSQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISADCPSLQSRLLVSD-SSRPGWMNFRELLRE-ASAEHNCVRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQASYGLGFFS----TF-
-GRRWVDLTK---SDIFWNTSD------------------------TGWVKAAWT-LFSA
WPHGSCIF-------------------------------VHELPRVDAKIILNT----LS
RLPITTLCCVPT---IFRLLVQ---EDLTRE-----------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKGQVGLE---LHEGYGQSET-VLI---CANTKG
MKIKSGSMGMA--SPPYDVQ------------IVDDEGNVLPPGEEGNIAV-RVRPTRPF
CFFSCYL-------------------NNPEKTEASERGDFYIT--GDQAHKDKDGYFWFT
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVENALA
EHPAVLEAAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSQDPKKLTQELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-NKL---RSQEWGE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMNF-------RVLR
GILKS---FHGFHPA--PQRLCSRFLSGPGAP-SWN--DY-VRPKEFNFASDVVDYWAQM
EMEGKRG-PSPALWWVNNQGDELKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 913)

SFREITELTCRTANVLTQTCGLQEGDYLALILP
RVPEWWLVAIGCIRT--GIIFM--PGTIQMTTK-D--ILYRLQVSKAKGIVTTDTLAPVV
DSLASEYPGLKTKLLVSD-QSCKGWLDFRSLIKS-ASPDHVCIKS---------------
------------------KTLDPMAVFFTSGTSGLPK-MTKHSHGL-ALRSVL---PSCR
---KFLKLKT---SDVFWCPSD------------------------TGWIMSMLGSLLEP
WTAGSTVF-------------------------------VHHLTQFDPKDMIQT-----L
QYPITYFLAAPS---GFRML-Q---QNPT-------------SLR----FPTLEHC----
----CTGGEALLPEEQEQ--------WRKQTGIL---LYQAYGQSET-GVT---CGIFRG
MKIKPGSMGKA--IPPFDIQ------------IIDDKGNILPPDTEGNLGI-RIKPVKPL
GLFMCYE-------------------NDPVKTAEVECGDFYNT--GDRATIDAEGYFFFL
GRADDVINA-----------------------------S------Y-RIGS-EE--CPWR
EHPAMAES---ASPGPI-RGE--------------------------------VVKAFIV
LTPKFLSHDRDQLTKELQQHVKSVTAPYKYPRK---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MLWLQKF----QRLCILW
GSRIP------KRTVH-----VHT--RQLASL-QWG--YQ-EVPPKFNFASDVLDHWADM
EK-AKRH-PGPALWWVNGDGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 911)

NFSQLSELSQQTANVFSGPCGLQRGDRVAVVLP
RVPEWWLVILGCMRA--GLVLI--PGSIQLKPK-D--ILYRLQVSNTRGIVAGDEVAQAV
DTVAPDCPALKTKILVSA-KSREGWLDFKTLLRK-TPTDAGCRAG---------------
------------------GKK--AAALLLNGTSGPP--NSEHSNSPLAIKATM----DA-
---DWTGLQA---SDIMWAILD------------------------TGWILNFLASLLEP
WTLGACTF-------------------------------IHLLPKVDPQVILKV----LS
TYPINNMLGAPL---IYRMLLL---QDLSS-------------YK----FPHLQHC----
----FSGGESLLPETLEN--------WKAQTGLD---IREFYGQTET-GLT---CRVSKT
TKVKPGCMGTA--IPHYDLQ------------VIDDKGNL-PPGTEGDG-IRV-KPITPI
GIFSGYV-------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX
XXXX-XXXX-----------------------------XX-----X-XXGP-SEVENAL-
MDDG-VEAAAVSSPDPF-RGE--------------------------------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--MEFVL-HL--PK------T------
--ITGKI--------NR-AKL---RNVEWKKSGQAGAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRLWLRG----LVLQVLR
RARGTC----GSPGRPPPLPAPQKVVATWEAI-SLG--RQ-PVPEYFNFAHDVLDMWSQL
EKAGHRP-PIPAFWWVDGMGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGEQSRKAANVLGGVCGLQPGDRVMLVLP
RLPEWWLVSVACMRT--GAVMI--PGISQLTEK-D--LRFRLQASKAKCIITNDSTAPQV
DAISADCPSLQTKLLVSD-SSRPGWVNFRELLRX-XXXXXXXXXX---------------
------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX----XXX
---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-TLSRF
PITTLCCV-------------------------------PTIFRLLV-------------
---------------------Q---E-DLTX------------XX----XXXXXXX----
----XXXXXXXXXXXXXX--------XXXXXXXX---XXXXXXXXXX-VVI---CANPKG
SKIKSGSMGTA--SPPYDVQ------------IVDDEGNVLPPGGEGDIAI-RIRPTRPF
CFFSCYL-------------------DNPEKTAASERGDFYIT--GDRAHVDKDGYFWFM
GRNDDVIIS-----------------------------SS-----Y-RIGP-IEVESALA
EHPAVLESAVVSSPDPT-RGE--------------------------------VVKAFIV
LSPAYSSRDPDTLTWELQEHVKRVTAPYKYPRK--VEFVS-EL--PK------T------
--VSGKI--------QR-SKL---RRQEWEK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRL-------RVLP
CIRKS---FQTFHRV--PPQLRCQSFSEVGAP-IWN--DH-DVPKEFNFASDVLDYWAQM
ETEGKRG-PE

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PALWWINTQGDEVKW--SFRDLKDLSCRMANVFTQTCGLQPGDHLTLILP
RVPEWWLVALSCIRT--GIIFI--PGTTQLKSK-D--IFYRLKMSNSKAIVTTDTLAPEV
DSVASECPALKTKLLVSE-HSLSGWLDLRSLTKS-ASPEHTCIKS---------------
------------------KTEDPMTIFFTSGTTGFPK-MAKHNHGL-ALRSYL---PTCA
---------------FSWCLSC------------------------ALWFLRVEARK---
-----GIL-------------------------------RRKQIKIPPFFT---F-QVLF
KYPITHCLAAPA---VFRAILQ---EKDA-------------NLR----FPTLKYC----
----HTGGESLLAEEFDQ--------WNKRTGIL---LHEIYGQSETVGA--------RD
MKIKPGSLGKA--IAPFDVQ------------IIDDKGNVLPPNTEGNIGV-RIKPTRPV
GLFMCYE-------------------NNPEKTAAVECGDFYDT--GDKASIDSEGYFWFL
GRNDDVINA-----------------------------SG-----T-VN-------NVAP
EHTFTATSFVFV----S-VLQ--------------------------------VVKAFIV
LNPPFQSHDQDQLIKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-QEL---RRREFGQQ----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MKSSF----QLFRFIW
FTKPP---VRSFHRD--HQLWAAMTPADFEAI-NRC--DR-PLPKSFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELSSLSQKAANVFTKSCGLQRGDRVVVILP
RIPEWWLINVACMRA--GLVFI--PGTIQLTAK-D--ILYRLQASKAKCIVVSEEVAPAV
QSIVSECPQLKNKVLVSP-HSGNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGFPK-MAQHSQSSLGIGYAL----CGR
---YWLDLKP---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHRMAQFDTDTFLDA----LT
TYPITHLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKEQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------VIDEKGDILPPGKEGDIAI-RLKSTRPF
CFFSEYV-------------------DNPEKTAATIRGDFYVT--GDRGLMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPYKSSNPEKLALELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------AG--WE-PVPEYFNFAHDVLDMWAQ

PF00501 // ENSGT00760000119178_4_Domain_0 (240, 587)

Q
EKAGHRP-SSPAFWWVDGKGAEVKW--SFDELGMQSRKAANILEKVCSLKPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQVSRAKSIITSDSLAPHV
DAISAECPSLQAKLLVSD-ASRPGWMNFRELLQ-----------T---------------
------------------KSGDPMSIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGS
---RWMGLTG---SDIFWNTTD------------------------TGWVKAAWS-LFPT
WAIGSCLF-------------------------------VHEMPRVDTKVILN-------
-------------------------------------------------FRSLRHC----
----LTGGEALNPDVREK--------WKCHTGLE---LHEGYGQSET-VPI---CANARG
TKIKSGSMGRA--SPPYDVQ------------IVDDEGNVLPPGEAGNIAV-RIRPTRPF
CFFRCYL-------------------DNPEKTAASEQGDFYIT--GDRGRMDTDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVASSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VNTLR-SR--SQ------QARKSDG
HMIPELI--------HE-ARL---CATQWEGRRGETYTPQILLQPPSFLPSFLPSFLPSS
LFSLSLSLSLSLSLSLLFSFFLFFSTGDRIQE----------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWLRKL----QRLCTLW
GTQMP---SHTLHIN--NRKLVSVQW---------G--HQ-EAPPTFNFARDVMDHWAEM
EKVGKRP-PGPALWWISGNGKEVMW--NFRELSEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWGLVVLGCIRA--GLVFM--PGTIQMKSA-D--ILYRLQMSKAKAIVAGDEVVQEV
DMVASKCPSLRIKLLVSE-KSCDGWLNFKKLLKE-ASTIHHCVVT---------------
------------------ESQETSAIFFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WSGLQA---SDVFWTIAD------------------------TGWILNFIGSF-ES
WATGACAF-------------------------------VHLLPKFDPLIILKT----LS
SYPVKTMLGAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGDTLLPEILGN--------WKAQTGLD---IRDCYGQTET-GLT---CIVSKT
MKTKPGYLGTA--IPNYDVQ------------VIDDKGNVLPPGEIGDIGI-RIKPIKPI
GIFCGYV-------------------DNPEKTAANIRGDFWLL--GDKGIKDEDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPI-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------N------
--ITGKI--------QR-DKL---RDKEWKKSGRARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------L

PF00501 // ENSGT00760000119178_4_Domain_0 (320, 627)

VFI--PGTPMLTAK-D--ILYRLQSSKAKCIITSEALVPTV
DAVAPDCPALKVKLLVSE-NRHDGWMDFRTLLRE-ASTIHSCVET---------------
------------------ASTEAQAIYFTSGTTGAPK-MAEHSHGSLSFKFKI----DA-
---IWIKLQT---SETMWSITD------------------------TGWILNILGTFLEP
WVSGACSF-------------------------------IHHLPNTDPLIIIKT----LS
RYPITSLIAAPS---VYRMLLQ---CDVSX-------------XX----XXXXXXX----
----XXXXXXXXXXXXXX--------XXXXXXXX---XXXXXXXXXX-XXX---XXXXXX
XXXXXXXXXXX--XXXXXXX------------XXXXXXXX-XXXXXXXX-XXX-XXXXXX
XXXXXXX-------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-----------------------------XX-----Y

PF00501 // ENSGT00760000119178_4_Domain_2 (887, 910)

-RIGP-AEVENVLN
EHPAVAESAVISSPDAN-QGE--------------------------------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--VEFVS-AL--PK------T------
--VTGKI--------LR-AKL---RKDEWK------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWTPLTLADFEAI-NRC--NS-PLPKNFNFAADVLDQWAQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGALSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFI--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVASAV
ESIALECPDLKTKLLVSP-QSRNGWLSFQELFRF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITALCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WREQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGEEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RTLW
GIHKS---FHNIHPA--PSQLRCRSLSEFGAP-RWN--DY-EVPEEFNFASYVLDYWAQK
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFREMGDLTRRVANVFTQTCGLQQGDHLALMLP
RVPEWWLVAVGCMRT--GIIFI--PATILLKAK-D--ILYRLQLSKAKGIVTIDALASEV
DSIASQCPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCVKS---------------
------------------KTLDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PGSR
---KLRSLKT---SDVSWCLSD------------------------SGWIVATIWTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQT----LL
KYPINHFWGVSS---IYRMILQ---QDFT-------------SIR----FPALEHC----
----YTGGEVVLPKDQEE--------WKRRTGLL---LYENYGQSET-GLI---CATYWG
MKIKPGFMGKA--TPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFMCYE-------------------GDPEKTAKVECGDFYNT--GDRGKMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------ER-KEL---RKKETGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLHY----QRFRFIW
LTKSA---GRHFHRD--PQLRTPLTLADFEAI-NRL--EK-PLPKNFNFAADVLDQWSQK
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KSGERP-ANPALWWVNGKGEEVKW--SFRDLGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEDVAPAV
DSIVSECPHLKTKLLVSP-HCWDGWLSFQELLQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTP---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFNTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKSLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANRKG
QEIKPGSMGKG--VVPYDVQ------------IIDENGNILPAGKEGEIAL-RLENTRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LAAPFKSSNHEKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RVLW
GIQKP---IHQFPPA--PWHLRCQCLS--EAP-KWN--DY-DRPEEFNFARDVLDYWSQM
EKEGRRG-PNPALWWVNSEGNEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFGEMTDLTCRVANVFSQTCGLQPGDGLVLLLP
RVPEWWLATVGCIRT--GVIVM--PGTTQMRAR-D--ILYRLQTSKAKGVVTTDALAPEV
DSVASECPALKVKLLVSD-HSRKGWLNFSSLTKS-ASPEHTCIKS---------------
------------------KTMDPMAIFFTSGTTGYPK-MAKHSHGL-ALRSSL---PSSR
---KWLQLKT---SDIFWCLSD------------------------PGWIVAFVGALLEP
WTAGSTLF-------------------------------IHHLPQFDPKVIVQMLF----
KYPITQCLGAPT---LFRMILQ---QNFP-------------SLR----FPTLEHC----
----NAGGEPLLPQEQEK--------WRRQTGVH---LSEVYGQSET-GLT---CAFYRG
MKIKPGSMGKA--IPPFDTQ------------IIDDKGNILPPHTEGNIGI-RIKPIRPI
GLFLGYE-------------------GDPKKTAEVECGDFYNT--GDKGTMDAEGYFWFL
GRSDDVINA-----------------------------SG-----F-RIGP-AEVEDALA
KHPAVAESAVVSSPDPI-RGQ--------------------------------VVKAFIV
LTPPFLSHDREQLTKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-SEL---RRKEFDQMQAATRP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKL----QGLCTLW
GAQMS---SLTPHIT--VRQLASVQW---------G--RQ-EVPATFNFARDVIDHWADM
ET

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 848)

AGKRP-PGPALWWVSDRGEEVKW--NYRELSEISRQAANVLLGPCGLRRGDCVAVVLP
RVPQWWLATLGCMRA--GLIFT--PGTVQMKSA-D--ILYRLQLSKAKVIVAGDEVAQEV
DMVAPKCPSLRMKVLVSE-KSQDGWLNFNTLLKE-ASATHRCVET---------------
------------------GSQEAAAFYFTSGTSGPPK-MVEHSHASLGLKAKI--DAG--
---IWTDLKP---SDIVWTVSD------------------------TAWILNMIGAFLEP
WTAGACTF-------------------------------IHHLPKFDPVVILKV----LS
TYPVTNLMGAPI---IFRMLLQ---QDLS-------------SYK----FPHLKNC----
----FSGGESLLPEILEK--------WRAMTGLD---IREVYGQTET-GLT---CRVSTT
MKIKPGYMGTS--IPSYDVQ------------VIDNEGNVLPPGTEGDLGI-RVKPLRPV
GIFSGYV-------------------NDPQRVADNIRGDFWLL--GDRAIKDEDGYFQFL
GRADDIINA-----------------------------SG-----Y-RIGP-SEVENALM
DHPAVVETVVVSSPDPV-RGE--------------------------------VVKAFVV
LAPEFLSRDRDQLTKELQQHVKSVTAPYKYPRK--MEFVS-DL--PK------T------
--ITGKI--------ER-VKL---RKMEWKMSGQARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQCLKKF-------QIPW
GIYKF---FHSFFPK--PSHQCSISTSRVETQ-RWN--DY-DSPEEFNFASDVLDYWAQM
EEEGKRG-PGPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 848)

WVNGQGDEIKW--SFQELRDLTRRAANVFEQTCGLQQGDRLALILP
RVPEWWLVTVGCFRT--GIVFM--PGTIQLKAK-D--ILYRLQRSQAKAIVTTGSLVPEV
DSVASECPALKTKLVVSD-HSHEGWLNFQSLIKS-VSPNHTCIKS---------------
------------------KMKDPLAIFFTSGTTGFPK-MAKHDQGL-AFRSCI---PSCR
---KVFGLKT---SDILWCMSD------------------------PGWILATVGCLIEP
WASGSTVF-------------------------------IHHLPQFDPNVIVEV----LF
KYPITQCLAAPA---V---------------------------LR----FPTVEHC----
----STGGESLLPEEYKQ--------WKQRTGLL---IHEVYGQSET-GIS---CAVFRE
MKIKIGSMGKP--VLPFNVQ------------VGLDPCVTA---------------DSRT
STSFSLQ-------------------NDPQMTAEVECGDFYNS--GDKATVDDDGYIWFL
GRGDEIINA-----------------------------SG-----Y-RIGP-TEVENALA
EHPAVAESAVVSSPDPN-RGE--------------------------------VVKAFIV
LTPEFLSHDQEQLTKELQQHVKSVTAPYKYPRK--VEFVT-EL--PK------T------
--VTGKI--------RR-KEL---RMKEFSQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLKVL-----ILQALK
SSRGF---CRSH-GQLVPLSVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNDMGAEVKW--SFEELGKQSRKAANVLRGACSLQPGDRIMLVLP
RLPEWWLVSVACMRT--GAVMI--PGISQLTEK-D--LKYRLQVSRAKSIITSDSLAVRV
DAISADCPSLQTKLLVSD-HSRSGWLNFRELLRE-APAEHNCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---QWMALTK---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLTR-------------HQ----FQSLRHC----
----LTGGEALNPDVREK--------WKHQTGLE---LHEGYGQSET-VVI---CANPKG
MEIKSGSMGKA--SPPYDVQ------------IVDDRGSILPPGEEGNVAV-RIRPARPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPTYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWEK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKIFF-RY----QTFRFIW
LTKLS---GQRFHKS--HQLGAPLTLADFEAI-NRC--EK-SLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFGELGSLSRKAANVLTKPCGLERGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRASKAKCVVASEEVIPAV
ESIVSECPDLKTKLLVSP-HSQNGWLSFSELFQT-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---TDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
NYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIAL-RLTSTRPF
CFFSEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVK-EL--PK------T------
--ITGKI--------KR-NVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWLRKL----QGLCILW
RTQIS---SRTVRLH--TKQLASLQW---------G--HQ-EVPPKFNFASDMIDHWASM
EKAGKRP-PGPALWWVSGDGNELVW--NFSQLSELSQQAANVLSGACSLQRGDRVMMVLP
RVPEWWLVTLGCMRA--GLVFI--PGTIQMRTK-D--ILYRLQVSKARAIVAGDEVAQLV
DTIASDCPSLKTKLLVSE-KSRDGWLDFRTLLRE-ASTTHCCVET---------------
------------------GSQEAAAIYFTSGTTGLPK-MAEHSHSSLGLKAKM--DIG--
---VWTDMQP---SDIIWVISD------------------------TAWILNILASFLEP
WAVGACSF-------------------------------IHLLPKFDPVIILKV----LS
SYPINNFVGAPI---IYQMLIQ---QDFP-------------SYK----FPHLQNC----
----YSGGDALLPDILEN--------WRARTGLD---IRELYGQTET-GIT---CRVSKN
MKIKPGYLGTA--IPHYDVQ------------VLDDKGNVLPPGIEGDIGI-RVKPIRPI
GIFSGYV-------------------DSPEKTAASIRGDFWIL--GDRAIKDQDGYFRFI
GRSDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVIETAVISSPDPV-RKE--------------------------------VVKAFVV
LAPQFLFHNLDQLTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--NTGKI--------QR-KKL---RDKEWKTSRQAEAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHM-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFGELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKF----RGLCTLW
GPQMS---GHTLYIN--IRQLASVPW---------G--HQ-ELPAKFNFARDVMDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 848)

KAGKRP-PSPALWWVSDSGDQRMW--NFRELSDVSQQVANVLSGACGLQRGDRVAVVLP
RVPEWWLVTLGCIRA--GLVFI--PGTIQLKSN-D--ILYRLQMSKAKAIVAGDEVAQEV
DMVTPKCPTLRIKLLVSE-KSRDGWLNFKTLLKE-ASITHHCVET---------------
------------------GSQEAAAIYFTSGTSGPPK-MAEHSHASLGLKSKM--DAG--
----WTGLQA---SEVLWTISD------------------------TGWILNVIGSFMEP
WSIGACTF-------------------------------IHLLPKFDPVVILKV----LS
SYPIHSMIGAPI---VYRMLLQ---QDLS-------------SYK----FPHLQSC----
----FSGGETLLPETLEN--------WKAKTGLD---IREFYGQTET-GLT---CRVSKT
MKIKPGYMGTA--SPRYDVQ------------VIDDNGNVLPSGKEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPQKTAANIRGEFWLL--GDQGIKDEDGYFQFM
GRKDDIINA-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LAPQFLSHDPNKLTKELQQHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--VTGKI--------ER-TKL---RDKEWKMSRQAQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKL----QGLCLRW
GTWMP---HRMVHIR--TRHLAPLQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRH-PGPALWWVNGNGDEVKW--NFRQLSELSQQAANVLSKVCSLQRGDRVAVVLS
RVPEWWLVVLGCMRA--GLVFL--PGTIQMKNK-D--ILYRLQVSKARAIVAGDEVAQAV
DTVAPDCPSLKTKLLVSE-KSQDGWLDFKTLLRE-ASTTHCCMET---------------
------------------GSQESAAIYFTSGTSGLPK-MAEHSHASLGIKAKM--DAG--
---KWTDLQA---TDIIWTISD------------------------TGWILNMLSSFLEP
WTSGACTF-------------------------------IHHLPTFDPLVILKV----LS
SYPINSMVGAPI---VYRMLLL---QDLS-------------SYK----FPHLKYC----
----FTGGETLLPDTLEN--------WRAQTGLD---LREFYGQTET-GLT---CRVSKT
MKVKPGHLGTA--IPHYDVQ------------VIDDKGNVLPPGTEGELGI-RVKPIRPV
GFFSGYV-------------------DNLEKTIANIRGDFWLT--GDRGIKDQD------
---------------------------------------G-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPI-RGE--------------------------------VVKAFVV
LDPQFLSHDLDQLTKELQQHVKLVTAPYKYPRK--IEFVL-DL--PK------T------
--VTGKI--------QR-AKL---RDKEWKRSEQARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTISD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGI-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARVQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSLQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRL-PSPALWWVNG

PF00501 // ENSGT00760000119178_4_Domain_0 (259, 849)

KGKELMW--NFRELSENSQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIKLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSYSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILCSLMEP
WALGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKSMMGAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----VTVGESLLPETLEN--------WRAQTGLD---IRESYGQTET-GLT---CMVSKT
MKIKPGYMGTA--ASCYDVQ------------IIDDKGNVLPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPDKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRANDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-AKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-QAGERP-ANPALWWVNGKGDEVKW--SFEELGSLSRKAANVLTDPCGLKRGDRVAVILP
HIPDWWLVNVACMRT--ELLVP---TEAMLTKNRK--IRVDFL-----LLINDNYYIKFL
KKKEYDCGNQLESLCLSF-SLCGGEGNLPILMTT-VFTDHQDENR---------------
------------------NSLEPISNNNMFGSLSVPGKFTHPERPSYVFY

PF00501 // ENSGT00760000119178_4_Domain_0 (471, 910)

FSI----SFR
---YWLDLKS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLQGACVF-------------------------------VHRMAQFDTDTLLDN----IK
YYIILKERTEKCLTNALNQSTQ---KECLFL------------YK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WEAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKQGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIAL-RPKSTRPF
CFFSEYV-------------------VKDVQSTSHFIGDFYTT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLILELQDHVKKSTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-NVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EEAGHRP-PNPAFWWVNGTGEEIKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFKELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASKAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLTRE-----------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--FPPYDVQ------------IVDDGGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYYSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWQK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQRLMRL-------QVLW
GICKS---YHGFHPA--PWYLCCRSLSGAGTL-RWN--DN-DRPKEFNFASDVLDYWTQM
EQEGKRG-PNPALWWVNNQGDEVKW--SFREMTDLSRRAANVFTQTCGLQQGDRLALILP
RLPEWWLVVIGCIRA--GIIFM--PATTQMKAK-D--ILYRLQVSKAQGIMTTDTLAPEV
DSLVSECPALKTKLLVSD-HSRHGWLDFRSLIKS-ASPDHTCIKS---------------
------------------KTLDPMAIFFTSGTTGLPK-MAKHSHGL-ALRSSL---PSCR
---KFLQLKT---SDVLWCISD------------------------PGWILAVLGCLFEP
WTSGSTLF-------------------------------IHHLPQFDPKVIQQT----LF
KYPITMCLGAPA---VYRMVLQ---QIST-------------SLR----FPALEHC----
----VTGGEALLPEEQEE--------WRRRTGVL---LHEVYGQSET-GIS---CGTLRG
MKIKPGSMGTS--IPPFDIQ------------IIDEKGNILPINTEGNIGI-RIKPTKPM
GVFMCYEQRTSVPVSPYPCRYLLNFQDNPVKTAEVECGDFYNS--GDRATMDEEGYIWFL
GRNDDVINS-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPI-RKE--------------------------------VVKAFIV
LTPEFLSRDQDQLTQELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-SEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLRCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PNPAFWWVNGQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREIADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTMDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFFGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEILWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALM
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTSQFLSHDKDQLTKELQDHVKSVTAPYKYPRK--VEFVP-DL--PK------T------
--ITGKI--------KR-KEL---QKKEMGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----P---SRTFHGN--NRLLTSQIISHYESI-NQG--KK-ELPEYFNFASDVLDEWARL
EKDGRKP-ANPAFWWVNEEGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 376)

SFEELGSLSRKAANVLSDACGLQRGDRVLAVLP
RVPEWWLLNVACMRA--GIVLI--PGTSQLTAK-D--ISYRLQASKAKCIVTNDTLAPAV
ESVLPGSQFLKSKLIVG-QGSRDGWLNFKELL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------NRHLWKMNR----LLLLFLW
LAKPP---GRHFHKD--YQHWAPLTLDDFEAI-NRC--ER-TLPKNFNFAGDVLDQWSQK
EKTGERP-ASPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFGELSSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLLNVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIAPDCPNLMTKLLVSL-HSRKGWLSFQELFQS-ASEEHSCVKT---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSHSSLGIGYTL----CGR
---YWADLKS---SDIIWNMSD------------------------TGWIKAAIGSVFFS
WIRGACVF-------------------------------VHQMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--ILPYDVQ------------IIDENGSILPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DEPEKTAATMRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVIESAVVSSPDPT-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NAL---RDQEWGRK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMKF----RVV----
--WTIHKSCHSFQPALQHLH-CG-SSSATRAQ-QWS--DH-DTPLEFNFARDVMDYWTQM
EKXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX--XIIFM--PGTTQMTAK-D--ILYRLQKSQAKGIVTTETLAPQV
DSVASACPSLKNKLLVSD-HHRDGWLDLWSLIXX-XXXXXXXXXX---------------
------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX----XXR
---KLLQLKP---SDTLWCLSD------------------------PGWILALLGAFLEP
WTAGATLF-------------------------------IHHLPQFDPKVIVEX----XX
XXXXXXXXXXXX---XXXXXXX---X-XXXX------------LR----

PF00501 // ENSGT00760000119178_4_Domain_0 (650, 734)

FPALEHC----
----GTGGEALLPEEQDK--------WEKETGIA---LHEIYGQSET-GIL---CGVLRG
MKIKSGSMGKA--ILPFDVQ------------XXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXX-------------------DDPEKTAQVECGDFYNT--GDRATIDEEGYFWFL
GRSDDVINT-----------------------------SG-----XXXXX--XXXXXXXX
XXXXXXXXXXXXXXXXX-XXX--------------------------------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--VEFVP-EL--PK------T------
--ITGKI--------KR-SDL---RKKEYGKM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKILLEI----QVLRSPW
SIQTF---YRLFHQC--RKTFAPLNLTDYEAI-GRC--EQ-EVPEYFNFASDVLDKWSQI
EKERKEP-SNPALWWINGKGGERKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFESRKVANVLSGPCGLQRGDRIIVILP
RIPEWWLLNTACMRT--GVVFI--PGTTQLTAK-D--ICYRLLASKAKCIVTIDALAPVV
DSVASQCQFLKTKLIVSE-SRRAEWLNFSDLLKA-APAVHNCVKT---------------
------------------RSQDPMTIYFTSGTTGFPK-MVEHSYGSFGLGFFI----CGR
---YWMNLTP---SDVVWSMSD------------------------TGWIKAAIGNVFGP
WFQGTCAF-------------------------------VHAMPQFDPKVILNT----LC
RYPVTTLCSAPT---VYRMLVQ---HDLT-------------RYT----FKTLKHC----
----LSGGEPVNPEVMEQ--------WKNQTGLN---IYEGYGQTEI-GLI---CGNMKG
MKIKPGSLGKA--APPYDVQ------------IIDEKGSVLPPGEEGDIAI-KIDAKRPF
TFFTRYV-------------------DDPVKTASTIRGNFYIT--GDRGSMDEDGYIWFM
GRSDDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPSFTTQDRKKLACELQDHVKKVTAPYKYPRK--IEFVE-QL--PK------T------
--ITGKI--------RR-SEL---RNKEWGQI----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----GLQALR
NFREF---CRVH-TQLPPLPVPEKILAVWEAI-SLG--RQ-PVPEYFNFAHDVLDMWAQL
EKAGHRP-SCPAFWWLDGRGAEVKW--SFAELGTQSRKAANVLGDACGLQPRDRMILVLP
RLPEWWLISVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQMSRAKSIVASDSLAPHV
DAISAECPSLQTKLLVSD-SSRPGWVNFRELLQE-ASAEHSCVRT---------------
------------------KSGDPLVIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGS
---RWLGLTG---SDVFWNTSD------------------------TGWVKAGWS-FFPT
WAMGSCVF-------------------------------VHEMPRVDTKVILNT----LS
TYPITNFCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLQHC----
----LAGGEALNPDVRDK--------WKRHTGLE---LHEGYGQSET-VAI---CANARG
TKIKSGSMGQA--SPPYDVQ------------IVDDEGNVLPPGEEGNIAV-RVRPTRPF
CLFNYYL-------------------DNPEKTAASEQGDFYIT--GDRGRMDTDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESVLA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYYSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWAR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTVYIN--TRQLVSVPW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PTPALWWVNGKGKELIW--NFRELNEISQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSSDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHEPVAIYFTSGTSGLPK-MAEHSHSSLGLKAKI--DAG--
----WTGLQG---SDVMWTISD------------------------TGWILNIITSLLET
WALGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKNMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CIVSKT
MKIKPGYMGIA--ARHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKALVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKLWRRGL-----VLQALR
SSWGI---CRVH-GQPPPPPVPE-AVATWEAI-SLG--RQ-PVPEYFNFAHDVLDTWSRL
EKVGQRP-PNPAFWWVNGSGAEVKW--TFEELGKQSRKAANVLEGVCGLKPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGISQLTAK-D--LKYRLQAARAKSIVTSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWISFREQLRE-ASAEHNCVRT---------------
------------------KSGDSVAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWIALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELSRVDAKTILNT----LC
RFPITTLCCVPT---LFRLIVQ---EDLT-------------RYK----FQSLRHC----
----VTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VLI---CSNSRG
SAIKSGSMGKA--SPPYHVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------ENPEKTASSEKGDFYIT--GDRAHMDEDGYLWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYTSRDPEALTRELQEHVKKVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QLFS---
LAQ-CFRLGFGACCYPNQKFPAQT-I-RPPDL-RSL--GQ-AVSQNFNFAKDVLDQWSQL
EKDGLRE-PYPALWEVSA

PF00501 // ENSGT00760000119178_4_Domain_0 (259, 846)

KGEEDKW--SSERMTQLSKKTASILSDTCALSHGDRLMIILP
PTPEAYWICLACVHL--GITFQESPLSPKLTAK-K--IRYQLHMSKAQCIVANEAMAPVV
NSAMSDCPTLKTKVLVSD-KSYDGWLDFKKLIQV-APPKQTCVRT---------------
------------------KSQDLMAIFFTEGTTGAPK-MAEYSQYGLGMGFSQ----TSR
---QWMDLQL---TDVLWSLGDAF-----------------------GG-SLSLSNVLEA
WLQGACLF-------------------------------LCRMPTFCPETVLNV----LS
RFPITTLSANPE---MYHKLL---------H------------YR----FKSLKHY----
----VAAGGCTSPGVIKD--------WKRTTKLN---IYEGYGQTET-GLL---CATSKI
IKLKPGSLGKP--LPPYIVQ------------IVDENLNIFKCRFL--------------
-DLSFYQ-------------------VSWEEYASARGHMLYLT--GGRGIMDEDSYFWLS
GRADDVANP-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLREL-----VLQALR
NARGI---CGSH-GQPPPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKAGHRP-PIPAFWWVDGTGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGEQSRKAANVLEGACGLQPGDRMMLVLP
RLPEWWLVSVACMRTASGAVMI--PGISQLTEK-D--LKFRLQASRAKAIITSDSLAPRV
DAISADCPSLQTKLLVSD-SYRPGWMNFRELLWE-ASTEHNCART---------------
------------------RSQDPVAIYFTSGTTGTPK-MVEHTQASYGLGFVA----SGR
YQGRWVALTK---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKFILNT----LS
RFPITTLCCVPT---IFRLLVQ---EDLTSE-----------RYQ----FQSLRHC----
----VTGGEALTPDVREK--------WKSQTGLE---LHEGYGQSET-VLI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------VVDEEGNILPPGEEGNVAI-RVRPTRPF
CFFTCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEKLTQELQEHVKRVTAPYKYPRK--MAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RRQEWENEKQ-PQKGPISH-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKSLFHY----QTFRFIW
LTKPP---GRHLHKH--HQLWMPLTLADFEAI-QRC--ER-SLPKNFNFAADVLEQWSQK
EKTGERT-ANPALWWVNGKGEEVKW--SFRELSSLSQKAANVLTKTCGLQRGDRVALILP
RIPEWWLLTVACIRT--GTVFI--PGTIQLTAK-D--ILYRLRASKATCVVASEEVAAAV
ESIAMECPDLRTKVLVSS-QSRNGWLSFQELFQL-ASEEHSCVET---------------
------------------GSEEPMAIYFTSGTTSFPK-MAQHSQSSLSIGSTL----CGR
---YWLDLKS---SDIIWNVSD------------------------TGWVKAAIGSLFSS
WMCGACVF-------------------------------VHQMVQFDTDTFLDT----LT
TYPITTLCSPPT---TYRMLVQ---KDLK-------------RYK----FKSLRHC----
----STGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANWKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAI-RLKPTRPF
CFFSEYV-------------------DNPEKTTATVRGDFYVT--GDRAVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALT
EHPAVAESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYDPEKLTLELQDHVKKTTAPYKYPRK--VEFVQ-EL--PK------T------
--VTGKI--------KR-HVL---RNQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAPVV
NSAVSDCPTLKTKLLVSD-

PF00501 // ENSGT00760000119178_4_Domain_0 (380, 888)

KSYDGWLDFKKLIQV-APPKQTYMRT---------------
------------------KSQDPMAIFFTKGTTGAPK-MVKYSQYGLGMGFSQ----ASR
---RWMDVQP---TDVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVIED--------WKRITKLD---IYEGYGQTET-GLL---CATSNT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-HIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWLS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MLWLGKI----PRYCTLW
GTEMS---IRTFHIN--IKKLLSIQW---------G--HQ-EIPAKFNFANDVIDHWANM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 314)

KAGKRP-PRPALWWMNGSGEELKW--NFRELSEISQRAANVLSGACGLQRGDRVAVVLG
QVPEWWLVTLGCIRT---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWTPLTLADFEAI-NRC--NR-PLPENFNFAADVLDQWAQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
ESIALECPDLKTKLLVSP-QSRTGWLSFQELFQF-ASEEHSCVET---------------
------------------RSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKSFLHC----RLFRFIW
VTQPS---VWSFHRD--ARLWAAMTPADFEAI-NRC--DR-LLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELSSLSRKAANVFTKSCGLQRGDRVVVILP
RIPEWWLINVACMRT--GLVFI--PGTTQLTTK-D--ILYRLQASNAKCIVVSEEVALAV
ESIVSECPNLKIKVLVSP-HSWNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGFPK-MALHSQSSLGIGYAL----CGR
---YWLDLKP---SDIIWNMSD------------------------TGWVKTAIGSVFSS
WLWGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRLLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GVI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------VIDEKGDILPPGKEGDIAV-RLKSTWPF
CFFSQYV-------------------DNPEKTAAVIRGNFYVT--GDRGLMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPYKSWNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NLL---RDQEWGRIKLQN------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRTLVKS-----WIPQCLW
ILRSP---SRSFHGN--NRLLTSQIVSYYESI-NQC--KK-ELPEYFNFASDVLDEWARL
EKDGRKP-ANPAFWWVNDKGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

TFEELGSLSRKAANVLSGACGLQAGDRVIAVLP
RVPEWWLLNVACMRA--GIVLI--PGTSQLTAK-D--ISYRLQASKAKCIITSDTLAPAV
ESVLPGS--LKSKLLVGQ-GSRDGWLNFKELLVV-ASADHQCVKT---------------
------------------RSQDPMIVYFTSGTTGFPK-MVVHSHSSYGIGFAI----SGR
---YWMNLTP---SDIMWNTSD------------------------TGWAKSAYGSVFAP
WICGSCVF-------------------------------VHHMPQFKPEVTAET----LS
RYPITTFCTAPT---AFRMLVQ---HDVS-------------SYK----FPSLKHC----
----VTGGEALNPEVFDK--------WKVQTGLV---IHEGYGQTET-VTI---CANMKG
TKIKPGSLGRA--VPPYDVQ------------IVDEHGAVVPAGAEGTIAV-RVRPWRPF
CLFSEYL-------------------DNPEKTAASVRGDFYLT--GDRGTMDEEGYIWFV
GRADDIINS-----------------------------AG-----Y-RIGP-FEVESALI
QHPAVSDVAVVSSPDPV-RGE--------------------------------VVKAFIV
LAPAFVSHDPEKLIHELQQHVKKVTAPYKYPRK--VEFVQ-DL--PK------T------
--TTGKI--------QR-KVL---RSKEWANV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRTFIKS-----WIPQCLW
ILRSP---SRSFHGN--NRLLTSQIISYYESI-NQC--KK-ELPEYFNFASDVLDEWARL
EKDGRKP-ANPAFWWVNDKGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

TFEELGSLSRKAANVLSGACGLQAGDRVIAVLP
RVPEWWLLNVACMRA--GIVLI--PGTSQLTAK-D--ISYRLQASKAKCIITSDTLAPAV
ESVLPGSQFLKSKLLVGQ-GSRDGWLNFKELLVV-ASADHQCVKT---------------
------------------RSQDPMLIYFTSGTTGFPK-MVMQSHSSYGIGFAI----SGR
---YWMNLTP---SDIMWNTSD------------------------TGWVKAAWSSVFAP
WICGSCVF-------------------------------VHHMPQFKSEVIAET----LS
RYPITTFCTAPT---AFRMLVQ---HDVS-------------SYK----FPSLKHC----
----VTGGEALNPEVLAK--------WKIQTGLV---IHEGYGQTET-VTI---CANMKG
TKIKPGSLGRA--VPPYDVQ------------IVDEHGAVVPAGAEGTIAV-RVRPWRPF
CLFSEYL-------------------DNPEKTAASVRGDFYLT--GDRGTMDEEGYIWFV
GRADDIINS-----------------------------AG-----Y-RIGP-FEVESALI
QHPAVSDVAVVSSPDPV-RGE--------------------------------VVKAFIV
LAPAFVSHDPEKLIHELQQHVKKVTAPYKYPRK--VEFVQ-EL--PK------T------
--ATGKI--------QR-KVL---KNKEWAKE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGP-----ALRALR
NGRGF---SGPR-GQPPRRPVPLKTVAMWEAI-NLG--RQ-PVPEYFNFARDVLDVWSQL
EEAGHRP-PNPAFWWVDGQGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

TFQELGEQSRKAANVLGSVCGLQQGDRVMLVLP
RVPEWWLANVACMRT--GAVMI--PGISQLTEK-D--LKYRLQTSKAKSIITSDSLAPRV
DAISADCPTLQTKLLVSD-SVRPGWQNFRELLQE-ASTEHSCVRT---------------
------------------KSHDPLAIYFTSGTTGAPK-MVEHSQASYGLGFVA----SGR
---RWAALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
RFPITTLCCVPT---IFRLLVQ---EDLAXX-----------XXX----XXXXXXX----
----XXXXXXXXXXXXXX--------XXXXXXXX---XXXXXXXXXX-XXX---XXXX--
XXXXXXXXXXX--XXXXXXX------------XXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXX-------------------ENPEKTAASERGDFYIT--GDRAHMDKDGYFWFM
GRQDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPAYLSHDPEKLTQELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKILFCHY----QTFRCIW
LAKAP---GRHFHRD--RHLWMPLTLADFEAI-NRC--DR-SLPKNFNFAGDVLDQWSEK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLVNVACMRT--GLVFI--PGTTQLTAK-D--MLYRLQASKAKCIVASEEVALAV
ESIMSECPDLKTKLLVSP-RERNGWLNFQELVQS-ASEEHSCVQT---------------
------------------GSQEPMAIYFTSGTSGSPK-MAQHSQSSLGIGHTL----SGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFAS
WLQGACVF-------------------------------VHRMAQLDTDNFLDT----LT
TYPITTLCSAPT---VFRMLVQ---KDLT-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANHKG
QEIKPGSMGKG--VQPYDVQ------------IIDENGNILPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPDKTAATLKGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-ALLHY----QRLRFIW
LAKPA---GRHFHRG--PQLWTSLTLADFEAI-NRC--EK-PLPKNFNFAADVLDQWSQK
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

SGERP-ANPALWWVNGQGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTRK-D--ILYRLQASKAKCIVASEEVAPVV
DSIVSECPNLKTKLLVSP-HRWDGWLSFQELLPS-ASEEHSCVET---------------
------------------GSQDPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLTP---SDIMWNMSD------------------------TGWVKAAIGSVFST
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----VTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANRKG
QEIKPGSMGKG--VVPYDVQ------------IIDENGNVLPSGKEGEIAL-RLDSTRPF
CFFSEYV-------------------DNPEKTDATIRGNFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LAAPFKSSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGQF----QLFS---
LVRGCSRLGCGSCCQPKRKFAAQT-V-KYSGS-RPI--GQ-AVPQHFNFAKDVLDQWSQL
EKDGLRG-PCPALWEVDA

PF00501 // ENSGT00760000119178_4_Domain_0 (259, 845)

KGKEDKW--SFERMACLSQKAASILSDTCALGHKDRLMIILP
PTPETYWIFLACVRL--GITFV--PGTPQLRAK-E--ILYRLCMSKARCIVANETMAPVV
DSVMSDCPSLKTKLLVSD-KSYDGWLDFRELIRV-APPKQTFMET---------------
------------------KSQDPMAIFFTNRTMGAPK-LVEYSQYGLGMEFSQ----VLR
---QWMDLQP---TDVLWSLGDIF-----------------------GG-TLSLSTVLGA
WLQGACVF-------------------------------LYHMPTFCPETVLNA----LS
RFPITTLCGKPE---MYQELLQ---HKHFIS------------YR----FKSLKHC----
----MAAGGSISPGVIKD--------WKRITNLD---IYEGYGQTET-GLL---CATSKR
MKLKPGSLGKP--LPPYTVQ------------IVDENSNILPVGEEGNIAV-RITLNQPA
SVYCPHM-------------------VSWEEYASGRSQMLYLT--GDRGIMDEDGYFWLA
GRADGVADI-----------------------------LG-----R-L------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRRL-----VLQALR
SSRGF---CGSR-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEVKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RIPEWWLVSVACMRT--GAVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSIAPRV
DAISAECPSLQTKLLVSE-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPQVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDAI-RGE--------------------------------VVKAFVV
LTPAYSSHDPEALTRELQEHVKSVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----VLHALK
SSRGF---SRSP-GQPAPPPVPQDIVATWEAI-SLG--KQ-PVPEYFNFAHDVLDVWSQL
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVSGTGAEVKW--SFEELGKQSRKAANVLSRACGLQPGDRMLLVLP
RLPEWWLVNVACMRT--GTVMI--PGTSQLTEK-D--LKYRLQLSRAKSIITSDSLAPRV
DAISADCPSLQTKLLVSD-SSRPGWLNFRELLRE-APAEHTCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MLEHSQCSYGLGFVA----SGR
---RWVALTE---ADIMWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRADAKCILNT----LS
TFPITTFCCVPT---MYRLLVQ---EDLT-------------RYR----FQSLRHC----
----ITGGEALNPDAREK--------WKRQTGLE---LHEGYGQSET-VVI---CGNTKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGSVLPAGEEGNIAV-RIRPTRPF
CFFNGYL-------------------GNPEKTASSERGDFYIT--GDRARMDEDGYLWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-AEVENALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSRDPEALTLELQNHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--SSGKI--------QR-KIL---RNQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRYLKKF-------QIPW
GIFKL---FHSFRLG--HRQLSCQSSSAVGAP-KWN--DH-DTPEEFNFASHVLDYWAQM
EEEGKRG-PGPALWWVNNQGDEVKW--SFRKIRDLTCRTANVFTQTCGLQQGDHLALILP
RVPEWWLVTVGCLRA--GIVYI--PGTSQLKAK-D--ILYRLQLSQAKAIVTTENLAPDV
DSMTSECPALKTKLLVSD-HSREGWLNLRSLIKS-ASPDHTCIKS---------------
------------------KMKDPMVIFFTSGTTGLPK-MAKHNQGL-AFRSCI---PSGR
---KVLQLKT---SDILWCMSD------------------------PGWILATVGCLIEP
WTSGATVF-------------------------------IHHLPQFDPKVIIEV----LF
KYPITQCLAAPT---VFRMILQ---AKFT-------------NLR----FPTLEHC----
----TTGGESLLPGEQDQ--------WRKQTGLL---IHEIYGQSET-GMT---CAVLRE
MKVKMGSMGKA--ISPFDVQ------------IIDEKGNILPPNTEGYIGI-RIKPIRPL
GLFMCYE-------------------NNPEKTAEVECGDFYNS--GDRAKVDDDGYLWFL
GRGDDIINA-----------------------------SG-----Y-RIGP-G

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALV
EHPAVAESAVVSSPDPE-RGE--------------------------------VVKAFIV
LTPEFLSHDKVQLIKELQQHVKSVTAPYKYPRK--IEFVP-EL--PK------T------
--ITGKI--------QR-KEL---RRKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
DQEGKRG-PNPALWWVNSQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 465)

SFRELTDFTCRAANVFTQTCGLQQGDRLALILP
RLPEWWLVAVGCIRT--GIIFM--PGTTQMKAK-D--ILYRLKESNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFRSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-ALRHSF---PS--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLREL-----VLQALR
NARGI---CGSH-GQPPPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PIPAFWWVDGTGAEVKW--SFEELGEQSRKAANVLEGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GAVMI--PGISQLTEK-D--LKFRLQASRAKAIITSDSLAPRV
DAISADCPSLQTKLLVSD-SYRPGWMNFRELLWE-ASTEHNCART---------------
------------------RSQDPVAIYFTSGTTGTPK-MVEHTQASYGLGFVA----SGR
---RWVALTK---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKFILNT----LS
RFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----VTGGEALTPDVREK--------WKSQTGLE---LHEGYGQSET-VLI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------VVDEEGNILPPGEEGNVAI-RVRPTRPF
CFFTCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEKLTQELQEHVKRVTAPYKYPRK--MAFVS-EL--PK------M------
--VSGKI--------QR-SKL---RRQEWENEKQ-PQKGPISH-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRWLWQL----QGVCTLT
GAQQC---SRNIHIH--PGRLAALLW---------G--HQ-DVPDKFNFASDVMDHWAGM
EKAGKRP-PGPALWWVSKHGEEVTW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFSQLSELSQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVTVGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQAFKAKAIVAGEEVAQEV
DTVAPDCHALRTKLLVFE-QKRNGWLDFKTLLRG-ASATHRCVET---------------
------------------RSQEAAAIYFTSGTSGFPK-MAEHSHASLGLKAKM--DAG--
---TWTGWKA---SDIVWTISD------------------------TGWILNILATLLES
WTLGACTF-------------------------------IHHLPKFDAQVILKV----LS
SYPINSLVGAPI---VYRMLLQ---QELS-------------SWK----FPHLPVS----
----FSEARSLLPETLES---------RVQTGLD---IREFYGQTET-GIT---CRVSKT
MKIKPGSLGTA--IPLYDVQ------------VLDDEGKVLPPDTEGELGI-RIKPIKPV
GIFSGYV-------------------XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXX
XXXXXXXXX-----------------------------XX-----Y-RIWP-SEVENALM
EHPAVVETVVISSPDPV-RGE--------------------------------VVKAFVV
LAPQFLSHDKAQLTKELQEHVKSVTAPYKYPRK---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRS-------RVLW
GIHKS---LHAFHPA--PPPLRCQSLSGVGAP-RWN--DQ-DIPKEFNFASYVVDYWVQM
EKEGKRG-PEPALWWINNQGDEVKW--SFSEIKDLSCRVANILTQTCSLQQGDHLALILP
RVPEWWLVALGCIRT--GIIFI--PGTTQLKAK-D--ILYRLQVSKAKAVVTTDTVVSEI
DSVVSECPALKTKLLVSD-HSLHGWLDLRSLIRS-ASPEHTCIKS---------------
------------------KTKDPMIIFFTSGTTGLPK-MAKHSHGL-ALRSYL---PTCR
---KLMRLKK---SDVFWCVSD------------------------PGWILAAVGGLFEP
WTAGCTLF-------------------------------IHHLPQFDPKVIIKA----LL
EYPITHCIAAPS---VFRMILQ---EKI---------------PR----FPTLKHC----
----FTGGESLLVEEFEK--------WKKQTGIL---LHEIYGQSET-GVT---CSVLQE
MKIKPGSMGKA--ISPFDVQFLKEASAKNYITIIDDKGNVLPPNTEGNIGI-RIKPTRPV
GLFMYYK-------------------DNPQKTAEVECGEFYNT--GDRATMDAEGYIWFL
GRSDDVIMS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPT-RGE--------------------------------VVKAFVV
LNPPFRSHDQNQLTKELQQHVRAVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-AEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
DQEGKRG-PNPALWLVNNQGDELKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 845)

SFGELTDLSRRAANVLTQTCGLQQGDRLALILP
RVPEWWLVVIGCIRA--GIIFM--PGTIQLKAK-D--ILYRLQVSKAKGIVTTDTLAPEV
DSLASECPTLKIKLLVSD-HSHQGWLDLRSLIKS-ASPDHTCIKS---------------
------------------KTVDPMAIFFTSGTTGLPK-MVKHCHGF-ALRSSL---PSCR
---KMLQLKT---SDIFWCFSD------------------------TGWILALFGCMMEP
WTVGATLF-------------------------------IHHLPQFDPKVVEQVR-RLIF
QYRQTQVLLS-----------L---CLPL-------------SLR----FPTLEHC----
----ITGGEALLPEDQEE--------WRRRTGLL---LYEIYGQTETVGVS---CGTPQG
MKIKPGSMGKS--MPPFDIQ------------IIDDQGNTLPFNTEGNIGI-RMKPTRPI
GLFMGYE-------------------DNPVKTSEVECGDFYNS--GDRATMDEEGYIWFL
GRKDD-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----GLQALR
NFREF---CGVH-TQLPPLPVPEKILAVWEAI-SLG--RQ-PVPEYFNFAHDVLDMWAQL
EKAGHRP-SCPAFWWLDGRGAEVKW--SFAELGTQSRKAANVLGDACGLQPRDRMILVLP
RLPEWWLISVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQMSRAKSIVASDSLAPHV
DAISAECPSLQTKLLVSD-SSRPGWVNFRELLQE-ASAEHSCVRT---------------
------------------KSGDPLVIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGS
---RWLGLTG---SDVFWNTSD------------------------TGWVKAGWS-FFPT
WAMGSCVF-------------------------------VHEMPRVDTKVILNT----LS
TYPITNFCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLQHC----
----LAGGEALNPDVRDK--------WKRHTGLE---LHEGYGQSET-VAI---CANARG
TKIKSGSMGQA--SPPYDVQ------------IVDDEGNVLPPGEEGNIAV-RVRPTRPF
CLFNYYL-------------------DNPEKTAASEQGDFYIT--GDRGRMDTDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESVLA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYYSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWAR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRVVFHC----RPLRFIW
LTKPA---GQYFHRD--HQLWTPLTPSDLEAI-NRC--DK-PLPENFNFAADVLDQWAQK
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

SGNRP-ANPALWWVNGKGGEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLLNIACMRT--GLIFM--PGTTQLTAK-D--ILYRLQASKAKCMVASEEVAPAV
ESIVSECPSLNNKLLVSP-RSRDGWLSFQELFQS-ASDEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLQGSCVF-------------------------------VHQMPKFNMDTFLDV----LT
NYPITTLCSAPT---VFRMLVQ---KDLR-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IVDEDGNALPPGEEGEIAI-RMKSTRPF
CFFSEYV-------------------DNPEKTAATMRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDST-RGE--------------------------------VVKAFVV
LSAPFKSSNLEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NLL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------QVLR
GIQKS---FYRFHPA--PQHLRSQCLS--EAP-KWN--DY-DRPEEFNFARDVLDYWSQM
EKEGRRG-PNPALWWVNGEGNEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFAEMTDLTCRVANVFSQTCGLQPGDGLVLLLP
RVPEWWLVTVGCIRT--GIIFI--PGTTQMRAR-D--ILYRLQASKAKGVVTTDALAPEV
DSVASECPALKVKLLVSD-HSRKGWLNFSSLIKS-ASPEHTCIKS---------------
------------------KTMDPMAIFFTSGTTGYPK-MAKHSHGL-ALRSSL---PSTR
---KWLQLKT---SDIIWCLSD------------------------PGWILAVLGALLEP
WTAGSTLF-------------------------------IHHLPQFDPKVIVQTLF----
KYPVTLCLGAPA---VYRMILQ---QNFP-------------SLR----FPTLEYC----
----SAGGEPLLPQEQEK--------WRRQTGVQ---LSEVYGQSET-GIT---CGIYRG
MKIKPGSMGKA--IPPFDMQ------------IIDDKGNILPPYTEGNIGI-RIKPIRPI
GLFLGYE-------------------GDPKKTAEVECGDFYNT--GDRATIDAEGYFWFL
GRSDDIINA-----------------------------SG-----F-RIGP-AEVEDALA
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAPPFLSHDQDKLTKELQQHVKSVTAPYKYPRK--KLYPV-SDTQKE------S------
--IAGKL--------TS-RKKSDKHPKLFIQE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LTMRWLRKF----EQLCTLR
GTEVP---SCPLHIS--VKKLTSVPW---------G--RQ-KVPAKFNFASDVVDQWAGM
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGKRP-PGPALWWVNDEGHEVKW--NFRELSEMSQRAANVLSGPCQLQHGDHVAVVLP
RIPEWWLVTLGCMRA--GLVFM--PGTIQLKSK-D--ILYRLRMSKARAIVAGDDVAHEV
DAVAANCPDLRIKLLVSE-RSRDGWLDFKTLLKE-ASTHHHCVES---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLCLKGKI--DSG--
----WTGLQP---SDLIWTISD------------------------TGWILNILTTLLEP
WSLGACVF-------------------------------IHLLPKIDPQTILKV----LS
SYPINCMVGAPL---VYRMLLK---QDLS-------------SYN----FPHLKNC----
----FTGGETLLPDTLQK--------WKTHTGVD---IREFYGQTET-GLT---CRVSST
MTIKPGYLGKA--VPHYDVQ------------VVDDEGNVLPPGKEGNIAV-RVKPIKPI
GIFSGYV-------------------GDPEKTAANIQGDFWLT--GDQGIKDQDGYFQFL
GRGDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVAETAVVSSPDPV-RGE--------------------------------VVKAFVV
LTPHFLSHDKDQLTKELQQHVKTVTAPYKYPRK--LEFVS-DL--PK---T---------
--IIGKI--------SR-QKL---RVMEWKTSEQTQ------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQCLGKG-------RVLW
GIFKS---NHSLNLA--PQQLHHQHVSGVGAS-RWN--DQ-EKPEGFNFASHVLDYWAQM
EKEGKRG-PEPALWWVNGQGNEIKW--SFREMSDLTQRTANILMQNCGLQQGDHLALVLP
RVPEWWLVTMGCIRT--GVIFM--PGTSQLKAK-D--IHYRLQESKAKAIVTTETLAPEV
DSIASECPALKSKILVSD-QGREGWLDFRSLIKS-ASPEHTCVRS---------------
------------------KVEDPMVIFFTSGTTGLPK-MVKHNQGL-ALRSYL---PSCR
---KLFQLRT---TDVLWCMSD------------------------PGWILATVGCLLEP
WTAGSTVF-------------------------------IHHLPQFDPQVIIQT----LF
KYPVTQCLAAPA---VYRMILQ---QKEA-------------NLK----FPTLEHC----
----STGGETLLPEEQEQ--------WKSRTGLL---LHEIYGQSET-GIA---CGVSRG
MKTKLGSMGKA--IAPFEVQ------------IIDDKGNVLPPDTEGYIGI-RTKPVKPV
GIFEGYE-------------------NNPEKNSEVQCGDFYNS--GDLAKMDSEGYIWFK
GRGDDIINA-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPR-RGE--------------------------------VVKAFVV
LTPKFQSHDQEQLTKELQQHVKLVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------RR-SEL---RRKEYGLK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRRLHKD--HQLWTPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDRLAVILP
RIPEWWLVNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIVLECPDLKTKLLVSP-QSWNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGFPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRVQTGLE---LYEGYGQTEV-GMI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKPTRPF
CFFSKYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRGR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWMPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWAQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFI--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIALECPDLKTKLLVSP-QSRTGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRTQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRL-------RVLP
CIHKS---FQTFHRV--PPQLRCQSFSEVGAP-IWN--DH-DVPKEFNFASDVLDYWAQM
EKEGKRG-PE

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PALWWINTQGDEVKW--SFRDLKDLSCRMANVFTQTCGLKPGDHLTLILP
RVPEWWLVALSCIRT--GIIFI--PGTTQLKSK-D--IFYRLKMSNSKAIVTTDTLAPEV
DSVASECPALKTKLLVSE-HSLSGWLDLRSLTKS-ASPEHTCIKS---------------
------------------KTEDPMTIFFTSGTTGFPK-MAKHNHGL-ALRSYL---PTCR
---KLMQLKK---SDVLWCVSD------------------------PGWILAAVGALFEP
WTTGSTLF-------------------------------IHHMPQFDPKVIIKV----LF
KYPITHCLAAPA---VFRAILQ---EKDA-------------NLR----FPTLKYC----
----HTGGESLLAEEFDQ--------WNKRTGIL---LHEIYGQSET-GIT---CGVFQD
MKIKPGSLGKA--ISPFDVQ------------IIDDKGNVLPPNTEGNIGV-RIKPTRPV
GLFMCYE-------------------NNPEKTAEVECGDFYNT--GDKASIDSEGYFWFL
GRNDDVINA-----------------------------SG-----Y-RIGP-MEVENALV
EQSRRGRVGCGEQPGSDARGG--------------------------------GESVY-C
SEPTVPV-------------------P---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------PGKEGDIAI-RVKPIRPV
GIFSGYV-------------------DNPKKTEANIRGDFWLL--GDRGTKDSEGYFHFM
GRTDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 998)

EVENALM
EHPAVAETAVISSPDPT-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRK--VRPLP-PV--SP------V------
--LS-KV--------PL-IQF---SSLA--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LTMLWVPKL----QGLCTRW
GTQIS---KRAFHVH--DKQLSPQQW---------G--NK-EVPAKFNFASDVMDHWAAM
EKAGQRP-PVPALWWVSGDGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFRDLSELSRQAANVLSGPTGLQRGDRVAVVLP
RVPEWWLVTLGCMRT--GLIFM--PGTIQMKAK-D--ILYRLQTSKARAIVAGDEVAEAV
DTVAPDCPALKTKLLVSQ-KSRDGWLDFKTLFQE-ASTAHRCVET---------------
------------------GSQEAAAIYFTSGTSGPPK-MLEHSHSSLGIKAKL--DAS--
---DWKDLQV---SDVVWTISD------------------------TAWILNIISSFLEP
WVSGACIF-------------------------------IHQLPKFDPVVILKV----LS
SYPINIITGAPV---IFRMLLQ---HDFS-------------SYK----FPHLRYC----
----YSGGEALLPDTLEK--------WRVRTGLD---IRECYGQTEM-GLI---CRVSRT
MKIKPGYMGTA--VPHYDVQ------------VLDDEGNVLPPGKEGELGI-RVKPIKPV
GMFSDHV-------------------GNPDKTAANIRGDFWLL--GDRAIKDEDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-SEVESALM
EHPAVVDSAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPQFLSHDRDQLTKELQQHVKTVTAPYKYPRK--IEFVS-DL--PK------T------
--NVGKI--------QR-YLL---RDKEWKNSGSV-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFHY----QIFRFSW
FIKPA---GRHFHRN--HQLGAHLALADLEAI-NRC--EM-SLPKNFNFAGDVIDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGQGDEVKW--SFRDLSTLSRKAANVLTKPCNLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTAK-D--ILYRLKVSKAKCIVASEEMAQAV
ESIASECPNLKTKLLVSP-QSHHGWLNFQDLFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLKS---SDIMWNMSD------------------------TGWIKAAIGSVFSS
WLRGACVF-------------------------------VHQMVQFDTNTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKMQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPSGTEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATMRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------FLKIMGW
EGGSV----------------VRALALHQKEKS--WKWCC-EL--PK------T------
--ITGKI--------KR-NVL---REQEWGQA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSLQW---------G--HQ-ELPAKFNFASDVLDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PSPALWWVNGKGKELMW--NFRELSENSQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIKLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAS--
----WTGLQA---SDIMWTISD------------------------TGWILNILCSLMEP
WALGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKSMMGAPI---VYRMLLQ---QDLS-------------SYK----FLHLQNC----
----VTVGESLLPETLEN--------WRAQTGLD---IRESYGQTET-GLT---CMVSKT
MKIKPGYMGTA--ASCYDVQ------------IIDDKGNVLPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKLVTAPYKYPRK--XXXXX-XX--XX------X------
--XXXXX--------XX-XXX---XXXXXXXXXXXXXX----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKNIFCY----QTFRLIR
LTKPP---GRHLHKH--HQLWTPLTLTDFEAI-HRC--ER-SLPKNFNFAADVLEQWSQK
EKTGERP-VNPALWWVNDKGDEVKW--SFRELSSLSRKAANVLTKPCGLQRGDRVALILP
RVPEWWLLNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRVSRAKCIVASDEVAPAV
ESIALECPDLKTKLLVSS-QTRNGWLSFQELFQL-ASEEHSCVET---------------
------------------GSEEPMAIYFTSGTTGSPK-MAQHSQSSLSIGSTL----CGR
---YWLDLKS---SDIIWNVSD------------------------TGWIKAAIGSVFSS
WLYGACVF-------------------------------VHQMVQFDTDTFLDT----LT
TYPITTLCSPPT---AYRMLVQ---KDLK-------------RYK----FKSLRRC----
----MTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GVI---CANQKG
QEIKPGSMGKR--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATVRGEFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 996)

EVESALI
EHPAVAESAVVSSPDRI-RGE---------------------------------------
-----------------------------------VEFVQ-EL--PK------T------
--VTGKI--------KR-HVL---RDQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FIW
LAKPT---GRFF-QD--HQLCASLTLADFEAI-NRC--EK-SLPKKFNFARDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-SNPALWWVNGKGDEVKW--SFEELGSFSRKAANVLTKPCGLKRGDRVAVILP
RIPEWWLVNVACMRT--GLVFM--PGTTQLTAK-D--ILYRLQASKAKCVVVSEDVVPAV
ESIMSECPNLKTKLLVSS-HSQDGWLNFQELFQS-ASSEHNCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MALHSQSSLGIGYTI----CGR
---YWLNLKS---SDIIWNVSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQLDTDALLDT----LT
TYPITTLCAAPT---VYRMLVQ---KDLK-------------RYK----FKKLQHC----
----LTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATIRGDFYVT--GDRGIMDSDGYFWFV
SRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKTTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-HVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTKE
MK

PF00501 // ENSGT00760000119178_4_Domain_0 (723, 911)

IKPGSMGKP--TAAYDVQ------------VVDENANILPPGMEGDIGI-RIKPTRPF
SLFSGYV-------------------DNPEKTAATERGNFYIC--GDRGVKDEDGYFWF-
GRADDIINS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAV-ESAVVSSPDPV-RGE--------------------------------VVKAFV-
LKDDFASHDPERLTLELQRHVQTVTAPY-YPRK--VEFVK-EL--PK------T------
--NTGKI--------RR--NL---RDQEW-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLCCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFRETADLTRRTANIFTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTIASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLIKS-ASPEHTCIKS---------------
------------------KTVDPMVIFFTSGTTGFPK-MAKHCHGL-ALQSSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------PGWILATMGALVEP
WTAGCTAF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFFGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLP---LYDIYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGNILPPNTEGNIGI-RIKPARPV
TLFMGYE-------------------GNPEKTAEVECGDFFNT--GDTGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLRCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFREIADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTMDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFYGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSLQW---------G--HQ-ELPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELMW--NFRELSENSQQAANVLSGACGLQRGDRVAVMLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--IMYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIRLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGSSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGSLLES
WTLGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKIMMSAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LAGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CIVSKT
MKIKPGYMGTA--ASCYDVQ------------VIDDKGNILPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPDKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
KHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
SSRGF---CGSR-GQLAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EKAGHRP-RNPAFWWVNGTGAEVKW--SFEELGKQSRKAANVLAGVCGLQPGDRMMLVLP
RIPEWWLVSVACMRT--GAVMI--PGITQLMEK-D--LKYRLQASRAKSIITSDSIAPRV
DAISAECPSLQTKLLVSE-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLVICFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWMALTE---SDIFWNMTD------------------------TGWVKAGWT-LFSA
WPNGSCIF-------------------------------VHELPQVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEAYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DSPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 957)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VTSAVKN
TAFCFCTHQHPSE-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFHY----QTFRFIW
LTKPP---GRRLHKD--YQLWTPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANMLTKPCGLQRGDRVAVILP
RIPEWWLVNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIVLECPDLKTKLLVSP-QSRNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGFPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GMI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKPTRPF
CFFSKYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRGR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRWLRKF----EQLCTLR
GTEVP---SCPLHIS--VKKLTSVPW---------G--RQ-KVPAKFNFASDVVDQWAGM
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 468)

AGKRP-PGPALWWVNDEGHEVKW--NFRELSEMSQRAANVLSGPCQLQHGDHVAVVLP
RIPEWWLVTLGCMRA--GLVFM--PGTIQLKSK-D--ILYRLRMSKARAIVAGDDVAHEV
DAVAANCPDLRIKLLVSE-RSRDGWLDFKTLLKE-ASTHHHCVES---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLCLKGKI--DSG--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------HC-GLT---CRVSST
MTIKPGYLGKA--VPHYDVQ------------DLGFG--------------------HAM
TSFCGHQ-------------------GDPEKTAANIQGDFWLT--GDQGIKDQDGYFQFL
GRGDDIINS-----------------------------SGL-LCRY-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_2 (894, 921)

EVENALM
EHPAVAETAVVSSPDPV-RGE--------------------------------IDEKHTG
----------------------S------VDLG--LEFVS-DL--PK------T------
--IIGKI--------SR-QKL---RVMEWKTS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------S-ASPEHTCIKS---------------
------------------K

PF00501 // ENSGT00760000119178_4_Domain_0 (440, 848)

TLDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PGSR
---ELWSLKT---SDVSWCLSD------------------------SGWIVATIWTLLEP
WTGGCTVF-------------------------------IHHLPQFDTKVIIQL----Y-
-----------------RMLP------QE-------------DIR----FPALEHC----
----CTGGEVVLPKDQEE--------WKRQTGLL---LYENYGQSET-GLI---CATYWG
MKIKPGFMGKA--TPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFMCYE-------------------GDPEKTAEVECGDFYNT--GDRGKMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-QGG--------------------------------VVKAFIV
LTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK--VSEGR------W------K------
--GSGDS--------IT-VDL---RKKETSQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDMWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDKGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDEDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRS-------RVLW
GIHKS---LHAFHPA--PPPLRCQSLSGVGAP-RWN--DQ-DIPKEFNFASYVVDYWVQM
EKEGKRG-PEPALWWINNQGDEVKW--SFSEIKDLSCRVANILTQTCSLQQGDHLALILP
RVPEWWLVALGCIRT--GIIFI--PGTTQLKAK-D--ILYRLQVSKAKAVVTTDTVVSEI
DSVVSECPALKTKLLVSD-HSLHGWLDLRSLIRS-ASPEHTCIKS---------------
------------------KTKDPMIIFFTSGTTGLPK-MAKHSHGL-ALRSYL---PTCR
---KLMRLKK---SDVFWCVSD------------------------PGWILAAVGGLFEP
WTAGCTLF-------------------------------IHHLPQFDPKVIIKA----LL
EYPITHCIAAPS---VFRMILQ---EKI---------------PR----FPTLKHC----
----FTGGESLLVEEFEK--------WKKQTGIL---LHEIYGQSET-GVT---CSVLQE
MKIKPGSMGKA--ISPFDVQFLKEASAKNYITIIDDKGNVLPPNTEGNIGI-RIKPTRPV
GLFMYYK-------------------DNPQKTAEVECGEFYNT--GDRATMDAEGYIWFL
GRSDDVIMS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPT-RGE--------------------------------VVKAFVV
LNPPFRSHDQNQLTKELQQHVRAVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-AEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------QVLW
DIQKS---FYHVHTA--PWPLCCQCLS--EAP-KWN--DY-DRPEEFNFARYVLDYWSQK
EKEGRRG-PNPALWWVNNDGKEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTCRVANVFSQTCGLQPGDSLVSLLP
RVPEWWLVTVGCISP--GIIFM--PGTTQMRAR-D--ILYRLQASKAKGVVTTDALAPEV
DSVASECPALKVKLLVSD-HSRKGWLNFSSLIKS-ASPEHTCIKS---------------
------------------KTMDPMAIYFTSETTGYPK-MAKHSHGL-ALLDNI---TVSR
---KCLQLKT---SDILWCLSD------------------------PGWIVAFVGGLLEP
WTAGSTVF-------------------------------IHHLPQFDPKVIVQSITFRKY
EVPIHPQLPHPT---TLPPITL---SPII-------------ILR----FPTLEHC----
----VTGGESLLPQELEK--------WRRQTGVQ---LSEIYGQSEM-GLG---CAIYRG
MKIKPGSIGKA--IPPFDIQ------------IIDDKGNILPPHTEGNIGI-RIKPIRPI
GLFLGYE-------------------GDPKKTAEVECGDFYNT--GDRATMDAEGYFWFL
GRSDDVINA-----------------------------SG-----F-RIGP-AEVEEALA
EHPAVAESAVVSSPDPI-RGQ--------------------------------VVKAFIV
LTPPFLSHDREQLTKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKV--------KR-SEL---RRKEFDQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRL-------RVLW
GTHKS---CHAFHLA--PRTLRFQSVSATGAP-RWK--DH-DRPEKFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNSQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELTDFTCRAANVFTQTCGLQQGDRLALILP
RLPEWWLVAMGCIRT--GIIFI--PGTTQMKAK-D--ILYRLKQSNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFRSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-ALRHSF---PSW-
---KLLQLKA---SDVFWCLSD------------------------PGWIVAVIGTLFEP
WTAGSTVF-------------------------------IHHLPQFDPKVIVET----LF
KYPITQYFAAPS---VYRMILQ---QNFG-------------SLR----FPTLEHC----
----AAGGEAVLPEEQEK--------WRQRTGLL---VHQVYGQSET-------------
--------------------------------IIDDEGNILPPNTEGNLGI-RIKPTKPI
GLFMLYE-------------------NDPVKTAKVECGDFYNT--GDKATIDEEGYIWFL
GRDDDIINA-----------------------------SG-----Y-RIGP-AEVESALA
EHPAVAESAVVSSPDPI-RGQ--------------------------------VVKAFIV
LTPQFLSHDPDQLAKELQEHVKAVTAPYKYPRK--VEFVP-EL--PK------S------
--VLGKI--------KR-SEL---REKEFGQMQQQGA-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLKKF-------QIPW
GIYKF---FHSFSPR--LSHQHRISTSGVGAQ-RWN--DY-DSPVEFNFASDVLDYWAQM
EEEGKRG-PGPALWWVNGQGDEIKW--SFRELRDLTRRAANVFEQTCGLQQGDRLALILP
RVPEWWLVSVGCLRT--GIVFM--PGTTQLKAK-D--ILYRLQASQAKAIVTTGSLVSEV
DSVASECPALKTKLVVSD-HSHEGWLNFQSLIKS-VSPNHTCIKS---------------
------------------KMKDPMAIFFTSGTTGLPK-MAKHNQGL-AFRSCI---PSCR
---KVFNLKT---SDIMWCMSD------------------------PGWILATVGCLIEP
WVSGATIF-------------------------------IHHLPQFDPKVIVEV----LF
KYPITQCLAAPA---VYRMILQ---QKIA-------------NLR----FPTVEHC----
----STGGESLLPEEYKQ--------WKQRTGLF---IHELYGQSET-GLS---CAVLRE
MKIKKGSMGKA--ILPFNIQ------------IIDEKGNILPPNTEGYLGI-KIKPTRPL
GLFVEYE-------------------DNPKMTAEVECGDFYNS--GDKATIDDDGYIWFL
GRSDEIINA-----------------------------SG-----Y-RIGP-T

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPN-RGE--------------------------------VVKAFIV
LTPEFLSHNQEQLTQELQQHVKSVTAPYKYPRK--VEFVT-EL--PK------T------
--ITGKI--------RR-KEL---RMKEFSQR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKIFF-RY----QTFRFIW
LTKLS---GQRFRKS--HQLGAPLTLADFEAI-NRC--ER-SLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFGELGSLSRKAANVLTKPCGLERGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRASKAKCVVASEEVIPAV
ESIVSECPDLKTKLLVSP-HSQNGWLSFPELFQT-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---TDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNAEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIAL-RLTSTRPF
CFFSEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVK-EL--PK------T------
--ITGKI--------KR-NVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKIL-LHC----RTFRLTW
LTKLS---GRHFHGN--HQIRAPLTTADFEAI-NLC--DK-SVPKNFNFAGDVLDQWSL

PF00501 // ENSGT00760000119178_4_Domain_0 (240, 849)

K
EQTGETP-ANPALWWVNGQGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACIRT--GLVFM--PGTTQLTAR-D--ILYRLQVSEAKGIVVSEEVAPAV
ESIVSECPNLKTKLLVSP-HSREGWLSFHQLFQS-ASEEHRCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSHSSIGIGYAV----CGR
---YWLDLKS---SDVIWNMSD------------------------TGWIKAAIGSMFSS
WLWGACVF-------------------------------VHRMASFDTDAFLDT----LV
TYPITTMCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----VTGGEPLNPEVMEQ--------WKAQTGLQ---LYEGYGQTEV-GII---CANVKG
QEIKPGSMGRG--VLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------NNPEKTAATLRGNFYVT--GDRGMKDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MTFLLKR----QIFNSIL
TPKSLCRFFSKHCRG----FAPQ-NISGYESP--NV--YK-ELPEHFNFASDVLDKWSQM
EKNGERASSIPALWWVGDQGNEVRW--GF

PF00501 // ENSGT00760000119178_4_Domain_0 (270, 773)

EELGFLSRKAANVLSDACGLKKGDRVIVMLP
RIPELWLITVGCMRT--GIIYI--PATIMLTAN-D--IFYRLQASKAKCIITNDTLAPAV
DSIVSKCEFLKTRLIVSE-GSRDGWLDFKKLFKD-AHDDHDTIKT---------------
------------------KSQEPMTIYFTSGTTGYPK-MVEHSHSSFGIGMTS----TGR
---LWLDLNP---SDVLWGLSD------------------------PGWVKFAYSCFFST
WIQGACIF-------------------------------TRHMLQFEATTVLDC----LS
RFPVTSFCGTPT---TYRMMAQ---H-DLTR------------YK----FKSLKRC----
----LSGGEPLSTEVMER--------WKKETGMD---IYEGYGQSET-VLI---CSLHKG
MKIKPGSMGKA--TPPYDVQ------------VIDENANVLPPGKEGDIAI-RIKPTRPF
CLFSHYV-------------------VREL------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----GLQALR
SFREF---SGVH-TQLPPLPDPQKILASWEAI-SLG--RQ-PVPEYFNFAHDVLDMWTEL
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGQWP-SCPAFWWVDGRGAEIKW--SFAELGTQSRKAANVLEDACGLQPGDRMMLVLP
RLPEWWLVGVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQVSRAKSLITSDALAAQV
DAISAECPSLQTKLLVSD-SSRPGWMNFRELLQE-ASTEHSCVKT---------------
------------------RSRDALAIYFTSGTTGAPK-MVGHSHCSYGLGFVA----SGS
---RWMGLTG---SDIFWNTSD------------------------TGWVKAAWS-LFPT
WAIGSCVF-------------------------------VHEMPRVDTKVILNT----LS
RFPITNFCCVPT---IFRLLVQ---EDLT-------------RYQ----FQRLRHC----
----LTGGEALNPDVREK--------WRCQTGLE---LHEGYGQSET-VTV---CANARG
TKIKSGSMGQA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAV-RVRPTRPF
CFFDCYL-------------------DNPEKTAASERGDFYIT--GDRGRMDTDGYFWFT
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESVLA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RDQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKSFLHC----RLFRFIW
VTQPS---VWSFHRD--ARLWAAMTPADFEAI-NRC--DR-LLPKNFNFAGDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELSSLSRKAANVFTKSCGLQRGDRVVVILP
RIPEWWLINVACMRT--GLVFI--PGTTQLTTK-D--ILYRLQASNAKCIVVSEEVALAV
ESIVSECPNLKIKVLVSP-HSWNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGFPK-MALHSQSSLGIGYAL----CGR
---YWLDLKP---SDIIWNMSD------------------------TGWVKTAIGSVFSS
WLWGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRLLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GVI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------VIDEKGDILPPGKEGDIAV-RLKSTWPF
CFFSQYV-------------------DNPEKTAAVIRGNFYVT--GDRGLMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPYKSWNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NLL---RDQEWGRIKLQN------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKL----QGLCTRM
GIQMS---NRTFHIH--AKQLAPLQW---------G--NQ-EIPAKFNFASDVVDHWAAM
EKTGQRP-PGPAMWWVSGDGEEIKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFRELRELSQQAANVLSGPIGLQRGDRVALVLP
RIPEWWLMILGCIRA--GVTFI--PGTIQMKAK-D--ILYRLQKSKAKAIVASDEVAEAV
DTVAPDCPALKTKVLVSK-KSRDGWLDFRKAFQE-ASTVHQCVET---------------
------------------GSQEAAAIYFTSGTSGPPK-MVEHSHSSLCLKAKV--DAS--
---AWKDLQV---SDVSWAISD------------------------TAWILNIICSLLEP
WASGACTF-------------------------------IHELPKFDPTVILKX----XX
XXXXXXXXXXXX---XXXXXXX---XXXX-------------XYK----FPHLRHC----
----YSGGDSLLPDTLEK--------WRDKMGLD---IREFYGQTET-GLT---CRVSRT
MKIKPGYMGTA--VPVYDVQ------------VIDNEGNVLPPGIEGDLSI-RVKPVKPI
GLFSGYV-------------------DNPQKTAANIRGDFWVL--GDRAIMDQDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVESALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LAPEFLSHDQDQLIKELQEHVKAVTAPYKYPRK--MEFVL-DL--PK------T------
--ITGKI--------QR-NLL---RDKEWKHSGRAQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLKSF-------Q---
-ICKV---LQGFSLS--PTQLHRRLFSRVGAP-RWN--DH-DSPEEFNFASDVLDYWAQM
EEEGKRG-PSP

PF00501 // ENSGT00760000119178_4_Domain_0 (252, 848)

AFWWVNGQGDEIKW--SFRKLRDLTCRTANVFEQICGLQQGDHLALILP
RVPEWWLVTVGCMRT--GIIFM--PGTTQLKAK-D--ILYRIQISRAKAIVTTASLVPEV
ESVASECPDLKTKLVVSD-HSHEGWLDFCSLIKS-ASPDHTCIKS---------------
------------------KMKDPMAIFFTSGTTGYPK-MAKHNQGL-AFRSYI---PSCR
---KLLKLKT---SDILWCMSD------------------------PGWILATVGCLIEP
WTSGCTVF-------------------------------IHHLPQFDPKVIVEV----LF
KYPITQCLAAPG---VYRMVLQ---QKTS-------------NLR----FPTLEHC----
----TTGGESLLPEEYEQ--------WKQRTGLS---IHEVYGQSET-GIS---SATLRE
MKIKRGSIGKA--ILPFDLQ------------IIDEKGNILPPNTEGYIGI-RIKPTRPL
GLFMEYE-------------------NSPESTSEVECGDFYNS--GDRATIDEEGYIWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-VEVENALA
EHPAVAESAVVSSPDKD-RGE--------------------------------VVKAFIV
LNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--VTGKI--------KR-KEL---RNKEFGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
NSRAF---CGSH-GQPAPLPVPQKIVATWEAI-SLG--RQ-LVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GTVMI--PGVNQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSD-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLAIYFTSGTTGDPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VWSPIDV
LKKSYLKRMPSSVCRELTGTVTNGCVLKLNPCI--V-L--------R------T------
--ESGV------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--KGERP-PNPALWWVNGKGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFRELGLLSRKVANALSKSCGLQGGDRVLVILP
RVPEWWLVTVACMRT--GLVFM--PGTIQLTAK-D--ILYRLTASKAKCIVASDEVAPAV
DSIVSNCPALKTKILVSE-NSCSGWLNFNELFQS-ASEEHNCMKT---------------
------------------SSREPMAIYFTSGTTGSPK-MALHSQSSLGIGYTL----CGR
---YWLDLKP---SDVMWNMSD------------------------MGWVKAAIGSVFST
WIRGACVF-------------------------------VHRMALFDTDIFLDT----LC
NYPITTLCSAPT---VYRMLIQ---KDLK-------------SYN----FKTLKHC----
----LTAGEPLNPEVREQ--------WKSQTGLE---LYEGYGQTEV-GVI---CCNYKG
NEIKPGSMGKG--IPPYDVQ------------IIDENCNIMPPGKEGEIAL-RLKSTRPF
CFFS----------------------DNPSKTAATIRGDFYVT--GDQGMMDSDGYFWFV
GRADDVIIS-----------------------------AG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRWLWKL----ERLCTLR
APGIS---TRPLHVS--VRQRTSVPW---------G--HQ-EVPAKFNFASHVIDLWASM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PGPALWWVNGKGDEVKW--TFRELSEMSQQAANVLLGPCSLQRGDRVAVVLP
QVPEWWLVTLGCMRA--GLVFM--PGAIQMKSK-D--ILYRLQASKARAIVAGDEVAHEV
DAVASDCPALRLKLLVSE-RSRDGWLDLKTLLKE-ASTTHHCVES---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLGLKGKM--DAG--
---TWTGLQP---SDLIWTIAD------------------------TGWMVNILTTLLEP
WALGACTF-------------------------------IHLLPKFDPQTVLKV----LS
SYPINSMVGAPL---VYRMLLQ---QDLS-------------SYK----FPHLKNC----
----FTSGETLLPQTLQN--------WKAQTGMD---IREFYGQTET-GLT---CRVSST
MIVKPGYLGTA--SPYYDVQ------------VIDDEGNVLPPGREGDIAI-RVKPIKPL
GIFSGYV-------------------DNPKKTAANIRGDFWLL--GDRGIKDQDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENVLM
EHPAVAEVAVVSSPDPV-RGE--------------------------------VVKAFVV
LTPHFLSHDKDQLTRELQQHAKSVTAPYKYPRK--LEFVL-DL--PK---T---------
--ITGKI--------SR-EKL---RAMEWKTTKKPQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EAPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTISD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLRCRSLSEIGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFREIADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTMDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PASR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFYGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LRDFCADQPGLKPMV

PF00501 // ENSGT00760000119178_4_Domain_0 (298, 910)

VK-
---EEIKQIISFSPP--GIIFM--PGTTQMKAK-D--ILYRLKESNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFRSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-SLRHSF---PSCR
---EVLQLKA---SDVLWCLSD------------------------PGWIVATLETMFEP
WTAGSTVF-------------------------------IHHLPQFDPKVIVET----LF
KYPITQYLTLPS---VFQMILQ---ENFS-------------SLR----FPTLEHC----
----STGGEAMLPEEQEK--------WRQRTGLL---VHQLYGQSET-GLT---CGTPRG
SQVKPGSMGKA--IPPFDIQ------------VIDDKGNILPPNTEGNLGI-RIKPTKPI
GLFMLYE-------------------NDPVKTAKVECGDFYNT--GDKATIDEEGYIWFL
GRDDDIINA-----------------------------SG-----Y-RIGP-AEVESALA
EHPAVAESAVVSSPDPI-RGQ--------------------------------VVKAFIV
LTPQFLSHDPDQLAKELQEHVKAMTAPYKYPRK--VS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLIRF-------RVFR
AIHKS---SYGFHPA--PWQVRCQSSSNAGAA-RWN--DH-EVPEEFNFANSVLDYWAQM
EKEGKRS-TNPAFWWVSSQGEELKW--SFREMADLTRRVANVFTQTCGLQQGDHLALILP
HVPEWWLVTVGCIRT--GIIIL--PGTIQLKAK-D--ILYRLQMSKAKAIVTTDTLAPEV
DSVAPECPALKNKFLVSD-HRRNGWLDLRSLMNS-ASPDHTCVKS---------------
------------------KTMDPMVIFFTSGTTGLPK-MAKHSHGL-ALRASF---PSCR
---KLMDLKM---SDVFWCLSD------------------------PGWVMCFFGSLIEP
WTAGSTVF-------------------------------IHHMPRVDPKVIVQT----LF
KYPITQLMGVPS---IFRMILQ---QNFT-------------SLR----FPTLKYC----
----YTGGEAQLPEDHKE--------WKRQTGLL---LYGIYGQSET-GAA---CGTLRE
MKIKLDSTGKA--LAPYDIQ------------IIDDKGNVLPPNTEGNIGI-RIKPTRPL
GIFMCYE-------------------GDPEKTAQSECGDFYNT--GDRATMDAEGYISFL
G

PF13193 // ENSGT00760000119178_4_Domain_1 (842, 1026)

RDDDIINA-----------------------------S---------------------
-----------------------------------------------------VVKAFIV
LTPQFLSQDRDHLTKELQQHVKSLTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------RR-SEL---RRKEFGLM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--LSQLRCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFREIADLTRRTANILTQTCGLEQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTMDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFFGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNIYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QLFS---
LAQ-CFRLGFGACCYPNRKFPAQT-I-RPPDL-RSL--GQ-AVSQHFNFANDVLDQWSQL
EKDGLRE-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 846)

EVSAKGEEDKW--SFERMTQLSKKTASILSDTCALSHGDRLMIILP
PTPEAYWICLACVHL--GITFV--PGSPKLTAK-K--IRYRLHMSKAQCIVADEAMAPVV
NSAVSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTCVRT---------------
------------------KSQDLMAIFFTKGTTGAPK-MVEYSQYGLGMGFSQ----TSR
---QWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSNVLGA
WLQGACLF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYRELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVIED--------WKRTTKLN---IYEGYGQTET-GLL---CATSKI
IKLKPGSLGKP--LPPYIVQ------------IVDENSNVLPLGEEGNIAI-RIKQNQPA
ALYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWLS
GRADDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSLQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRL-PSPALWWVNG

PF00501 // ENSGT00760000119178_4_Domain_0 (259, 849)

KGKELMW--NFRELSENSQQAANILSGACGLQRGDRVAVMLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIKLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSYSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGSLLES
WTLGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKSMMGAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LAGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CMVSKT
MKIKPGYMGTA--ASCYDVQ------------VIDDKGNVLPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------ENPDKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
KHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVI
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKILF-CY----QTFRFIW
LPKPS---GRHFHKD--HQLWAPLTLADFEAI-NRC--ER-SLPKNFNFAGDVLDQWSQK
EQTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELGSLSRKAANVLTKPCGLKRGERVAVILP
RIPEWWLLNVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRASKAKCIVASEEVVPAV
ESIVSECPDLKTKLLVSP-RSQNGWLSFQELFQS-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKNLQHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANLKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRKATVEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDHEWDRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQRLMRF-------LDLW
NIYKP---SHGFHSA--SGYLHCQALSEVGAP-RWN--DY-DVPKEFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNNKGDELKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFSELTDLTRRTANVFTQICGLQQGDRLAVVLP
RVPEWWLVAIGCMRT--GIVFM--PGTMQLTSK-D--LLYRLQVSKAKGIITTDTFAPEV
DSLASRCPTLKTKLLVSD-HSCQGWLDLRSSIKS-ASPDHTCIKS---------------
------------------KTLDPMAIFFTSGTTGFPK-MAKHSHGF-ALRSSF---PSSR
---KFLQLKT---SDIFWCHSD------------------------TGWILAVFGCILEP
WTAGATLF-------------------------------IHHMPQFDPKVAEQM----LF
KYPITQCFAASS---IYRMILQ---HTST-------------SLR----FPTLEHC----
----TTGGEALLPEEQEE--------WRRKTGLL---LHEAYGQSET-GIC---CSTLRG
MKIKPGSMGKS--MPPFDVQ------------IIDDKGNSLPCNTEGNIGI-RIKPTKPI
GIFMGYE-------------------DNPEKTAEVECGDFYNT--GDRATMDEEGYIWFL
GRDDDIINA-----------------------------SG-----N-RIGP-SEVENALC
EHPAVAESAVVSSPDPI-RRE--------------------------------VVKAFIV
LTPEFLSYDRDQLIKELQQHVKSITAPYKYPRK--VEFVS-EL--PK------T------
--INGKI--------KR-SEL---RKKEYGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QPFS---
LVR-SFRLGFEACCYPNQKCATQT-I-RPPDS-RCL--VQ-AVSQNFNFAKDVLDQWSQL
EKDGLRG-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 846)

KVSAKGEEDKW--SFERMTQLSKKAASILSDTCALSHGDRLMIILP
PTPEAYWICLACVRL--GITFV--PGSPQLTAK-K--IRYQLRMSKAQCIVANEAMAPVV
NSAVSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTYMRT---------------
------------------KSQDPMAIFFTKGTTGAPK-MVEYSQYGLGMGFSQ----ASR
---RWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKQC----
----VAAGGPISPGVIED--------WKRITKLD---IYEGYGQTET-GLL---CATSKT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-RIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWWS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------PRHSHSQSVSATGAP-RWN--DH-DRPEKFNFASDVLDYWTQM
EKEGKRG-PNP-----NSQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELTDFTCRAANVFTQTCGLQQGDRLALILP
RLPEWWLVAMGCIRT--GIIFM--PGTTQMKAK-D--ILYRLKESNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFRSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-ALRYSF---PSCR
---KLLQLKA---SDVLWCLSD------------------------PGWIMASVGTLFKP
WTAGSTVF-------------------------------IHHLPQFDTKVIVET----LF
KYPITQYITAPC---VFRMILQ---ENFR-------------SLR----FPTLEHC----
----STGGEALLPEEQEK--------WRQRTGLL---LYQLYGQSET-GLT---CGTPRG
SPLKPGSMGKA--IPPFDLQ------------VIDDEGNILPPNTEGNLGI-RIKPTKPI
GLFMLYE-------------------NDPVKTAKVECGDFYNT--GDKATIDEEGYIWFL
GRDDDIINS-----------------------------LG-----Y-RIGP-AEVESALA
EHPAVAESAVVSSPDPI-RGQ--------------------------------VVKAFIV
LTPQFLSHDPDQLAKELQEHVKAVTAPYKSPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-SEL---REKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQALLRF----HRYRSLW
ASCQS---CCPLHLQ--PRRMVQQDIL-------GA--RNPEIPEKFNFANDVLDHWAQM
EKEGKKA-LTPALWWVSGEGDEMKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

YQELGDLTRQAANVLSDACGLQQGDRVIVILP
RIPEWWLAVVGCIRA--GLVFI--PGTPLLVTK-D--ILYRLKTSKAKCIITNEALAPTV
DAVASDCPALKVKLLVSE-NRRDGWMDFRALLRE-APTAHNCTKT---------------
------------------GGEEAMTIYFTSGTTGNPK-MAEHSHGSLGFKALM--DAR--
---SYSDVQV---SETIWSILD------------------------TGWILNLLGTFLEP
WTSGACSF-------------------------------IHQLPRNDPMIIVNT----LC
KYPINVMLAPPM---LYRMLLN---QDLT-------------RFK----FQSLHSC----
----LSAGEILLPETLQK--------WRMQTGLN---IKEIYGQTET-GIT---CRYSS-
KEGKPGFMGKA--VPNYTVQ------------IIDDNGNVLPPGTKGEIGI-KIKPIKPV
GFFSGYV-------------------DNAEKTAANTLGNFWRM--GDLGIMDKDGNFQYI
GRADDIINS-----------------------------RG-----Y-RIGP-SEVENALN
EHPAVAESAVISSPDAN-QGE--------------------------------VVKAFVV
LDPKFKSHDQEELIRELQKHVKATTAPYKYPRK--VEFVS-TL--PK------T------
--VTGKI--------QR-AKL---RKDEWKQPTRT-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKILFKL-----RILQSLW
IPQSP---SRLFHKD--NRCLVSPMVSHYESI-NRC--KE-ELPDYFNFASDILDKWSQL
EKDGKRS-AIAAFWWINDKGDEVKW--S

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FEELGFLSRKGANVLSDPCGLQKGDRVIVILP
RIPEWWILNVACMRT--GIVFI--PGTSQLTAK-D--IFYRLQASKAKCIITNDTLAPTV
DSVSPDCQFLKTKLIVSE-CSRDGWLNFKELLKV-APADHNCIKT---------------
------------------KSQDPMLIYFTSGSTGPPK-MVEHSHSSYGLGFTV----SGR
---YWLNLTP---LDIFWNTSD------------------------TGWVKSAWSSLFSP
WSCGSCVF-------------------------------IHYMPQFEPATVANT----LS
RYPITTFCTAPT---AYCMLVQ---HGLT-------------SYK----FMSLRHC----
----VTGGEPLNPEVMEQ--------WKTQTGLD---IYEGYGQTET-VTI---CANVKG
MKIKPGSMGKA--SPPYDVQ------------VVDDWGNILPRGEEGNIAI-RIKPTRPF
CLFSCYL-------------------DNPEKTASTERGNFYIT--GDRGRMDEEEHFWFV
GRADDIINS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPAFVLHDPAKLALELQEHVKKVTAPYKYPRK--VEFVQ-EL--PK------T------
--VAGKI--------QR-KVL---RNKEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RVLW
GIHKS---CHGFFPA--PQHLHCQPLSGAKTS-RWN--DY-DTPKEFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNDQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTRRAANVFTQTGGLRQGDHLALILP
RVPEWWLVTVGCIRT--GIVFM--PGTTLMKAR-D--ILYRLQVSKAKGIITTDTLAPEV
DSVASECPALKIKFLVSD-HSRKGWLDFRSLIKS-ASSDHTCVKS---------------
------------------KTMDPMAIFFTSGTTGLPK-MAKHNQGL-ALRSSF---PSCR
---KLLQLKT---SDVFWCLSD------------------------PGWITATLASMLEP
WTAGSTVF-------------------------------VHHLPQFDHNVIVQT----FF
KYPITQCLAAPS---VFRMILQ---QDFT-------------SLR----FPTLEHT----
----CAGGEALLPEEQEQ--------WRRQTGVL---LYQVYGQSET-GIT---CGILRG
MKIKPGSMGKA--IPPFDIQ------------IIDDKGNVLPPDTEGNIGI-RIKPTKPI
GLFMCYQ-------------------DDPVKTAEVECGDFYNT--GDRATMDAEGYIWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-TEVESALA
EHPAVAESAVVSSPDLI-RGE--------------------------------VVKAFVV
LTPQFLSRDRGQLTKELQEHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-NEL---RKKEFGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRRLHKD--HQLWTPLTLADFEAI-NRC--NR-PLPKNFNFAADVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANMLTKPCGLQRGDRVAVILP
PIPEWWLVNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPAV
ESIVLECPDLKTKLLVSP-QSRNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGFPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLD---LYEGYGQTEV-GMI---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKPTRPF
CFFSKYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRGR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MFTCSIC--VPS--
---TWTGLQP---SDLIWTIAD------------------------TGWMVNILTTLLEP
WALGACTF-------------------------------IHLLPKFDPQTVLKV----LS
SYPINSMVGAPL---VYRMLLQ---QDLS-------------SYK----FPHLKNC----
----FTSGETLLPQTLQN--------WKAQTGMD---IREFYGQTET-GLT---CRVSST
MIVKPGYLGTA--SPYYDVQ------------VIDDEGNVLPPGREGDIAI-RVKPIKPL
GIFSGYV-------------------DNPKKTAANIRGDFWLL--GDRGIKDQDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENVLM
EHPAVAEVAVVSSPDPV-RGE--------------------------------VVKAFVV
LTPHFLSHDKDQLTRELQQHAKSVTAPYKYPRK--LEFVL-DL--PK---T---------
--ITGKI--------SR-EKL---RAMEWKTTKKPQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF----RVI----
--WGIHKSFHGFHTAPWKLR-FQ-S-SGVGAP-RWN--DN-DMPEEFNFASYVVDYWAQM
EKXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX--XXXXX--XXXXXXXXX-X--XXXXXXXX

PF00501 // ENSGT00760000119178_4_Domain_0 (346, 901)

NAKGIVTTDDLAPAV
DSVASECPSLKIKLLVSD-HSRKGWMDSRSLIKS-ASPEHTCIKS---------------
------------------KVMDPMTIFFTSGTTGFPR-MAKHSHGLALRSSLP----SSR
---KLLQLKT---SDILWCVSD------------------------PGWILAVFGCLLEP
WTSGSTVF-------------------------------SHNLPQFDPKVIIQT----LS
EYPITQFIAAPM---VFRMILQ---Q-KLTS------------LR----FPTLEHC----
----CTGGEALLPEVHEQ--------WKQQTGLL---LHEAYGQSET-GLT---CAVFRG
MKMKLGSMGKA--ISPYDVQ------------IIDGKGNILPPNTEGNIGI-RMKPTKPF
GLFMCYE-------------------NNPEKTAEVECGDFYNT--GDRATVDSDGYFWFL
GRSDDVINA-----------------------------SS-----AVPSN--LDYIGEXX
XXXXXXXXXXXXXXXXX-XXX--------------------------------XXX----
-------------------XXXXXXXXXXXXXX--XVESN-PL--PK------P------
--ITGKN--------EQ-NGF---WKKLG-LT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MLWLK------------K
GIYKF---FHSFSSS--PSQQHSVSTSGVWPQ-RWN--DY-DSPEEFNFARDVLDYWAQM
EEEGKRG-PGPALWWVNNQGDEIKW--SFRELRDLSRRTANVFEQSCGLKQGDRLALILP
RVPEWWLVTVGCFRT--GIVVM--PGTTQLKAK-D--ILYRLQASQAKAIVTTGSLIPEV
DSVASECPALKTKLVVSD-HSHDGWLNFQSLMKS-VSADHNCINT---------------
------------------KMKDPMAIFFTSGTTGHPK-MAKHNQGL-AFRSCV---TSCR
---DVLKLKT---SDILWCMSD------------------------PGWILASVGCVTQP
WASGATIF-------------------------------IHHLPQFDPKVIIEV----RK
PTSRSR-----N---PLRGYTG---FPKL-------------SLR----FPTLEHC----
----STGGESLLPEEFKQ--------WKERTGIF---IHELYGQSEM-GLG---LGVFRD
MKIKKGSMGKA--ILPFDFQ------------IIDEKGNILPPNTEGYLGI-RIKPTRPL
GLFVEYE-------------------NNPEKTAEVECGDFYNS--GDRASVDEDGYFWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVGSPDQK-RGE--------------------------------VGGHRNQ
LLHDY------TLLQESGETCRTQWSPWRSP-Q--IEFVP-EL--PK------T------
--ITGKI--------KR-KEL---RIKEFSQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--AGK

PF00501 // ENSGT00760000119178_4_Domain_0 (246, 849)

RP-PSPALWWVNGKGKELMW--NFRELSENSQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSQAKAIVAGDEVIQEV
DTVASECPSLRIKLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGSLLET
WASGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKHMMGAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GFT---CIVSKT
MKIKPGYMGTA--ASCYDVQ------------VIDDKGNILPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPDKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
KHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-TKL---RDKEWKMSGKASAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--MPPIFHWLRGKKI------------PYFPSCPSRQVCGTMRLRLARL-----LLQPLW
GSQAF---YKPLRYVSIGLPRPQKTITDFEAI-LEG--KQ-AIPEYFNFASDVLDMWTQM
EKTGKRP-PNPAFWWINGQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGIQSRKAANVLSRVCNLRPGDRLLVILP
RIPEWWLVNVACMRT--GIIII--PGISQLTMK-D--IQYRLQASGAKAIVTIDSLAPQV
DAISADCPSLRTKVLVSG-SSRQGWLNFRELCQTQTPQEHNCVKT---------------
------------------KSQDPSVIYFTSGTSGAPK-MLEHTQIGYGVGFSI----CAR
---KFMDLTN---SDIFWNTSD------------------------TGWVKTAWS-SYST
WITGACLF-------------------------------THELPKTDTSLILNT----LC
QMPITVFCCVPT---MFQMIVQ---QDLS-------------RYK----FKSLRHC----
----VAGGESLNPDVRTK--------WKSQTGVD---LYEGYGQSET-TLI---CGNQIG
KKIKPGSMGKA--FPPYDVQ------------IVDDEGNILPPGKEGNIGI-RIKPKLPI
CFFTGYL-------------------NNAEKTASCKRGDFYLT--GDCAHMDEDGYFWFK
GRMDDVINS-----------------------------SS-----Y-RIGP-FEVESALS
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFVV
LNSNFINQDPGELTRELQDHVKRLTAPYKYPRK--VEFVQ-EL--PK------T------
--VSGKI--------QR-SIL---RKKEWGN-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LTMHWLWKL----KRFCTLR
GIAIS---SRPLHIS--ARQLTSVPW---------G--HQ-DMPAKFNFVSDVVDHWADM
EKAGKRP-PGPALWWVNGGGDEVKW--NFRELSTMSRRAANVLSGCCGLQRGDRVVVVLP
QVPEWWLVTLGCVRA--GLVFM--PGTIQMKSK-D--ILYRLQVSKAKAIVAGDEVAPEV
DSVVADCPALRIKLLVSE-RTRDGWLDFKTLLKE-ASTVHRCVES---------------
------------------GTQEAAAIYFTSGTSGLPK-MAEHSHASLFLKGKM--DAG--
----WTGLQA---SDLIWTISD------------------------TGWIVNILTTLLEP
WTLGACVF-------------------------------IHLLPKFDPQTILKV----LS
SYPINIMVGAPL---VYRMLLQ---QDLS-------------SYK----FPHLRNC----
----FSGGESLLPDTLKN--------WKTQTGVD---IREFYGQTET-GLT---CKVSST
MTIKPGYLGTA--IPHYDVQ------------VIDDEGNILPPGKEGNIAV-RVKPIRPV
GIFCGYV-------------------DNPKKTAANIRGDFWLL--GDRGIKDQDGYFQFL
GRGDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVAETAVVSSPDSV-RGE--------------------------------VVKAFVV
LTPHFLSHDKDQLTRELQQHVKSVTAPYKYPRK--LEFVL-NL--PK---T---------
--ITGKI--------SR-EKL---RAMEWKTSEHSQ------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRGL-----VLHALK
NSRGF---SRSH-GQPPPPPAPQKIVATWEAI-SLG--KQ-PVPEYFNFAHDVLDVWSQL
EKAGHRP-PNPAFWWVSGTGAEVKW--SFEELGTQSRKAANVLSRACGLQPGDRMMLVLP
RLPEWWLVNVACMRT--GTVMI--PGTSQLTEK-D--LKYRLQLSRAKSIITSDSLAPRV
DAISADCPSLQIKLLVSD-SSRPGWLNFRELLRE-APTEHTCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MLEHSQCSYGLGFVA----SGR
---KWAALTE---SDIVWNMTD------------------------TGWVKAAWT-LFFA
WPNGACIF-------------------------------VHELPRVDAKFILNT----LS
TFPITNFCSVPT---MCRLLLQ---EDLT-------------RYQ----FQSLRHC----
----VTGGEVLNPDAREK--------WKRQTGLE---LYEGYGQSET-VLI---CANTKG
MKIKSGSMGKA--FPPYDVQ------------IVDDEGNVLPPGEEGNIAI-RIRPTRPF
CLFNGYL-------------------DNPEKTARSERGDFYIT--GDRARMDEDGYVWFT
GRNDDVINS-----------------------------SS-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEALTLELQDHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--ASGKI--------QR-KTL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LGIMKTW----LTFRFIW
LAKPS---GRHFHRD--HQRWASLTLADFEAI-NRC--DR-SLPKNFNFAGDVLDQWSQK
EKVEIRP-FPPFFLFLSGSVERIKRENLFHQIPITSLRGLQIRLLPCGNAYLTQVLAVWT

PF00501 // ENSGT00760000119178_4_Domain_0 (301, 910)

MYCEYWLSNSAILKV--RLVFM--PGTTQLTAK-D--ILYRLRVSKAKCIVASEEVAPAV
ESIVSECPHLKTKLLVSP-ESRNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDMDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLQHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGSVLPPGKEGEIAL-RVKSTRPF
CFFSEYV-------------------DNPEKTAATIRGHFYVT--GDRGVMDTDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNLEELTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KHNNIL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (319, 910)

AVII--PGVTQLTEK-D--LKYRLQASRAKTIITTDSLAPRV
DAVSADCPSLQTKLLVSD-SSRPGWVDFREHLRE-ASAEHTCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-----------------------
---------M---AEHSQCSYG------------------------LGFVASG--XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXT----LS
RFPITTLCCVPT---IFRLLVQ---ED--------L-----TRYQF-HSLR---HC----
----LAGGEALNPDVREK--------WKRQTGLE---LHEGYGQSET-XXX---XXXXXX
XXXXXXXXXXX--XXXXXXX------------XXXXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXX-------------------DNPEKTAASEQGNFYIT--GDRAHMDEDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHQAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSPAYSACDPEELTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SIL---RRQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRYM-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKTLLKL----QILKSLW
LPKSR---CRLFHKQ--PRLLASQLFSHDKSA-RQD--EL-QVPEYFNFASDVLDKWSQL
EKDGKRP-SNPAFWWVSGEGNEVRW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFHSKKVANVLSEICGLQKGDRIMLILP
KIPEWWLVNVACMRT--GIALI--QGTSQLTAK-D--ILYRLQASKAKCIIASDTVASAV
DSVASHCQFLKTKLIVS-EGRRDGWLNFNELYKS-QPADHICVKT---------------
------------------KIQDPMVIYFTSGTTGSPK-MAEHTQGSLGLRPVI----SER
---YWLDLTP---EDIMWCLSD------------------------TGWIVASMGSVLDP
WVFGSGVF-------------------------------VHNLPRAESTVILNT----LS
RFPITAMFAAPT---LFRMLVEVPYQDLN-------------SYK----FMSLQQC----
----LSGGEPLNPEVTEQ--------WKRKTGLT---IREIYGQTET-GII---CSVFKG
MKIKPGSMGKA--VPLYDVQ------------IIDENANVLPPGQEGDIAL-RIKPKRPI
GLFSKYI-------------------DNPEKTAESERGNFFVT--GDRGTRDEDGYFWFL
GRSDDIINS-----------------------------SG-----Y-RIGP-FEVESALL
EHPAVAESAVVSSPDPL-RGE--------------------------------VVKAFVV
LSAAFSSCDLEKLTLELQEHVKKVTAPYKYPRK--MEFVQ-QL--PK------T------
--ITGKI--------KR-HEL---RNKEWGRK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYLN--SRQLVSLQW---------G--HQ-ELPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELRW--NFRELSENSQQAANVLSGACGLQRGDRVAVMLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIRLLVSE-KSCDGWLNFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGSSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGSLLES
WTLGACTF-------------------------------VHLLPKFDPLVILKV----RE
DPR-GWV---------I-SLLC---PQIS-------------NGP----SRHLFGC----
----SKG--------------------SIRCGLD---FRRKLSSNNT-

PF00501 // ENSGT00760000119178_4_Domain_0 (709, 849)

GLT---CIVSKT
MKIKPGYMGTA--ASCYDVQ------------VIDDKGNILPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------VRNCKTAANIRGDFGSL--ETGGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--VTGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
NSRAF---CGSR-GQPAPLPVPQKIVATWEAI-SLG--RQ-LVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 591)

AGHRP-PNPAFWWVNDTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GTVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSD-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILN-------
------------------------------------------------------------
------------------------------------------------VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ----------------------------------------
--------------------------DNPEKTAASEQGGFYIT--GE-ARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESGVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
--------------------------------------------MTTGSLDLPFVGS---
------HRWI-----------------K-------WTTASLTMHHLWKI----PRLFTLW
GNEIS---CRTFHMN--IKKLIPIQW---------G--HQ-EAPAKFNFASDVIDHWASV
EKAGKRS-SGPALWWMNGSGKEIKW--SFRELSEASKQTANVLSGACGLHRGDRVAVVLP
RIPEWWLMILGCMRT--GLVFM--PGTIQMRSS-D--ILYRLQASKARAIVAGDEVAQEV
DAVAPDCSFLKIKLLVSE-NSREGWLNFKALLKE-ASTIHQCVET---------------
------------------ESRESAAIYFTSGTSGPPK-MAEHSHCSLGIKAKM--DAA--
---SWTGLST---SDIIWTISD------------------------TAWIMNILGAFLEP
WVLGACIF-------------------------------VHLLPKFDSQTVLKV----LS
SYPINTLVGAPI---IYRMLLQ---QDLS-------------SYK----FPHLHSC----
----FSGGETLLPETLEN--------WKAKTGLE---IREIYGQTET-GLI---CRVSRT
MKVKPGYLGTA--FAHYDVQ------------VIDEQGNVLPPGKEGDIAI-RVKPIWPI
GMFSGYV-------------------DNPKKTQDNIRGDFWLM--GDRGIKDPEGYFHFI
GRSDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVSETAVISSPDPS-RGE--------------------------------VVKAFVV
LAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--VTGKI--------ER-AKL---RAKEWKTSGRA-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-A-GKRG-PHPALWWVNGEGQEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 818)

NFSQLSEVGQQVANVLTGPCGLQRGDRVAVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTVQMRAK-D--ILYRLQASKARAIVAGDEVAQAV
DTVAPECPALSTKLLVSE-EKRDGWLDFKTLLRG-ASTTHRCVET---------------
------------------ASQEPAAIYFTSGTSGLPK-MAEHSHASLGLKAQM----DAG
---IWISPKA---SDIIWTVSD------------------------TGWILNILASFLEP
WAAGACTF-------------------------------VHLMPKFDPLVILKV----LS
SYPISHLVGAPI---VYRTLLQ---QDLSS-------------HK----FPHLQHC----
----FSGGEALLPETLES--------WQAQTGLD---IREFYGQTET-GVT---CRVSKT
MEIKPGSLGTA--IPHYDVQ------------XXXXXXXX-XXXXXXXX-XXX-XXXXXX
XXXXXXX-------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-----------------------------XX-----X-XXXXXXXXXXXXX
XXXX-XXXXXXXXXXXX-XXX--------------------------------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--VEFVP-EL--PK------T------
--VTGKI--------QR-SEL---RKKEWEKSAAA-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVLR
NSRGF---CGSR-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 382)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACIRT--GVVMI--PGVTQLTEK-D--LKYRLQSSRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELL----------------------------
-----------------------------------------------------------R
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--FPPYDVQ------------IVDDEGNVLPPGEEGNIAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RALR
GIRKS---FHGIQAA--PWPLRCQSVSGAGAP-RWN--DF-DKPEEFNFASYVMDYWAQM
EQEGRRG-PNPALWWVNSEGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFSEVASLTRRTANVFTQSCGLQRGDFLALILP
RIPEWWLVAIGCIRT--GIVFM--PGTTQLKAK-D--ILYRLQASKAKAVVTTDTLAPEV
DSVASECPALKAKLLVSD-HSRDGWLDFHSLIQS-ASPEHTCIKS---------------
------------------KTEDPMAIFFTSGTTGLPK-MAKHSHSL-ALRSYL---PSCR
---KLQQLKP---SDISWCPSD------------------------PGWILAVVGSLLEP
WTAGSTIF-------------------------------IHSLPQFDPKLMVEV----LS
KYPITQFLAAPS---VFRMILQ---QNFT-------------SLR----FPTLQHC----
----STGGEALLPEEQEK--------WKKQTGLL---LHEIYGQSEV-GMS---CGVPRG
TKIKPGSMGKA--ISPFDVQ------------IIDSKGNVLPPNTEGSIGI-RIKPTRPT
GLFMCYE-------------------NNPEKTAEVECGDFYNT--GDRATMDEEGYIWFL
GRDDDVINA-----------------------------SG-----Y-RIGP-TEVENALA
EHPAVKESAVVSSPDTS-RGE--------------------------------VVKAFIV
LNPQFLAHNQQQLTKELQEHVKAMTAPYKYPRK--VEFIP-EL--PK------T------
--ITGKI--------KR-NEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MMIFF-RY----QTFRFIW
LAKPT---GRYLHKD--HQLWAPLTLADFEAI-NRC--EK-SLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGSLSRKAANVLTKPCGLKRGDRVAVILP
RIPEWWLVNVACMRT--GLVFM--PGTTQLRAK-D--ILYRLRASKARCIVASEEVVPAV
ESIMSECPDLKTKLLVSP-RSQNGWLSFQELFQS-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFSS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKR--VLPYDVQ------------IVDENGNILPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATVRGDFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-NTL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RLPQ
GISKL---IHSFHLA--PQLRHYQPLSGVEAQ-RWS--EH-NIPEEFNFASHVLDYWAQM
EKEGKRG-PNPALWWMNSQGDEVKW--SFSELKDLTCRTANLFTQTCGLRQGDHLALILP
RVPEWWLVAVGSIRT--GIIMM--PGTTQLKAK-D--ILYRLQLSQAKAIVTVDSLAPEV
ESVASECPALKTKLLVSD-HSREGWLNFRSLIKS-ASPDHTCIKS---------------
------------------KMEDPMMIFFTSGTTGFPK-MVKHNQGL-AFRSYI---PASR
---KTMQLTT---SDIMWCLSD------------------------PGWILAAVGCMLEP
WTAGSTVF-------------------------------IHNLSQFDPKLIIEV----LF
KYPITQCLAAPG---VYRMILQ---QKSA-------------NLR----FPTLEHC----
----TTGGESLLPQECEQ--------WQKRTGLL---LHEIYGQSET-------------
--------------------------------IIDDKGNVLPPNTEGYIGI-RIKPIRPI
GIFMGYE-------------------NDPEKTAEVECGDFYNT--WDRAIIDEEGYFWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1025)

EVENALA
EHPAVAESAVVSSPDPT-RGQ--------------------------------VVKAFVV
LTPEFLSHDQDQLIKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--VTG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKILFQL----QMFRFIW
NPKFP---RRYFHQG--YQVLAPLNLSDFEAI-NRC--ER-DLPENFNFAGDVLDRWAQL
EQKGERP-PNPALWWINDKGAEVKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FRELGLLSRKVANALTKSCGLQRGERVAVILP
RVPEWWLVNVACMRT--GLIFM--PGTIQLTAK-D--ILYRLTASKAKCIVASDEAAPAV
DSIVSNCPALKTKILVSE-NSRSGWLDFNELFKS-ASEEHNCVKT---------------
------------------GSQEPMAIYFTSGTTGSPK-MALHSQSSLGIGYTL----CGR
---YWLDLKP---SDIMWNMSD------------------------TGWVKAAIGSVFST
WLQGACVF-------------------------------VHRMTQFNTDIFLDT----LN
NYPITTLCSAPT---VYRMLVQ---KDLK-------------SCN----FKTLRHC----
----LTGGEPLNPEVREQ--------WKSQTGLE---LYEGYGQTEV-GII---CANQKG
NEIKPGSMGKG--VPPYDVQ------------IIDENCNILPPGKEGDIAL-RLKSTRPF
SFFSEYV-------------------DNPSKTAATMRGNFYVT--GDRGIMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSALFKSANTEKLALELQNHVKKVTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
---------------------------------------------MITVLTSRLRGT---
------RSCF----------FQRRTEQAIPRELCREDLANLTMRWLWKL----ERFCTLR
GIEMP---RHPLHIN--VRPLTSVPW---------G--HQ-EVPAKFNFASDVVDQWADM
EKAGKRP-PGPALWWVNGGGEEVKW--NFRELSEMSQRAANVLSGPCSLQRGDRVAVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTIQMKSK-D--IFYRLQVSKARAIIAGDEVAHDV
DAVAADCPALRIKILVSE-RSQDGWLDFKTLLKE-ASATHHCVES---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLCLKGKM--DAR--
---AWTGLQA---SDLIWTISD------------------------TGWIVNILTTLLEP
WTLGAGIF-------------------------------IHLLPKFDPQTILKV----LS
CYPINSMVGAPL---VYRMLLQ---QDLS-------------SYK----FPHLKNC----
----FSGGESLLPDTLKN--------WKVQTGVD---IREFYGQTET-GLT---CRVSST
MTIKPGCLGTA--VPHYDVQ------------VIDDEGNILPPGKEGNIAI-RVKPIRPV
GIFSGYV-------------------DNAKKTAANIRGDFWLL--GDRGIKDQDGYFQFL
GRGDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1011)

EVENALM
EHPAVAETAVVSSPDPV-RGE--------------------------------VVKAFVV
LTSHFQSHDKDQLTRELQQHVKSVTAPYKYPRK--VTRCI-NP--FRLAKTISR------
--IQEYF--------TR-FRN---RTINWISVTGSLQNLRQPLHS------ALWNFPPSS
FFP---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRD-SPASASQVAG---------------
-------------------------------ITGA------RHHTRLNFVFLV----EMG
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDEGNVLPAGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFSRY----QTFRFIW
LAKPP---GRHFHRD--RQLWTPLTLADFEAI-NRY--DR-PLPKNFNFAGDVLDEWSQK
EKTGETS-GNPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLERGDRVAVILP
RIPEWWLVNVACMRT--GLVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAVAV
ESIVSECPHLKTKLLVSP-CGRNGWLSFQELFQ---------------------------
------------------------------------------------------------
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSTFSS
WLRGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VVPYDVQ------------IIDENGNILPPGKEGEIAL-RLKSTRPF
SFFSEYV-------------------DNPEKTAATLRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FD

PF13193 // ENSGT00760000119178_4_Domain_1 (895, 1026)

VESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTVELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--TTGKI--------KR-NVL---RDQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIS--TRQLVSVPW---------G--HQ-EVPAKFNFASDVVDHWADM
EKAGKRP-PTPALWWVNGKGKELIW--NFRELNEISQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQTSKAKAIVAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKI--DAG--
----WTGLQG---SDVMWTISD------------------------TGWILNIITSLLET
WALGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKNMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--ARHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIQGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QLFS---
LVQ-SFRLGFGACCYPNRKCAAQT-I-RPPDS-RCL--VQ-AVSQNFNFAKDVLDQWSQL
EKDGLRG-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 394)

KVGAKGEEDKW--SFERMTQLSKKAASILSNTCALSHGDRLMIILP
PTPEAYWICLACVRL--GITFV--PGSPQLTAK-K--IRYQ-------------------
---------------------------------V-APPKQTYMRT---------------
------------------NSQDPMAIFFTKGTTGAPK-MVKYSQYGLGMGFSQ----ASR
---RWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPAFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVIED--------WKRITKLD---IYEGYGQTET-GLL---CATSKT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-RIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWWS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------RMLWLRGW-----VLQVLR
NARGF---CGPQ---QPLLPDPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDMWSQL
EKAGHRP-QIPAFWWVNGKGTEVKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FEELGEQSRKAANVLQGMCGLQPGDRMMLVLP
RLPEWWLVSVACIRT--GAVMI--PGVSQLTEK-D--LKYRLQASRAKSIITTDSLAPRV
DAINADCPFLQSKLLVSD-SSRPGWMNFRKLLRE-ASTEHNCVRT---------------
------------------KSQDPLAIYFTSGTTGAPK-MVEHSQASYGLGFVA-----S-
-GRRWVDLTK---SDIFWNTSD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKIILNT----LS
RYPITTLCCVPT---IFRLLVQ---EDLTRE-----------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKSHVGLE---LHEGYGQSET-VLI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNILPPGQEGNLAV-RVRPTRPF
CFFSCYL-------------------NNPEKTEASERGDFYIT--GDRAHKDKDGYFWFS
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVENALA
EHPAVLEAAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPSYSSQDPEKLTQELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-NKL---RIQEWGE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTVYIN--TRQLVSVPW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PTPALWWVNGKGKELIW--NFRELNEISQQAANVLSGACGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSSDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHEPVAIYFTSGTSGLPK-MAEHSHSSLGLKAKI--DAG--
----WTGLQG---SDVMWTISD------------------------TGWILNIITSLLET
WALGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKNMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGESLLPETLEN--------WRAQTGLD---IREFYGQTET-GLT---CIVSKT
MKIKPGYMGIA--ARHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKALVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKTLAKS----RLFKFCW
ILRGP---HQPFHGH--PRFLSSPIFAQYEAV-SQG--KQ-PIPEYFNFANDVLDKWSQL
EKDGKRP-SNPALWWINGRGGEVRW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 909)

SFEELGVLSRKVANVLSDRCGLRKGDRILAILP
RIPEWWLVTVACIRT--GITVM--PGTTQLTAK-D--IQYRLRMSKAKCIITTDVLAPVV
DSVTADNHDLKTKLVVTSGGQREGWLGFNELLKE-APADFTNVQT---------------
------------------KVQDPMIIYFTSGTTGSPK-MTELSQGSMGLRPII----NPR
---YWLDFSP---LDIMWCTAD------------------------TGWVLSCLGALFDP
WVLGSCVF-------------------------------VHNLPQVESTTILNT----LS
RFPITAMLGAPT---LFRMLVQ---NDLS-------------SYK----FMSLKHC----
----VSAGEALNPEVMEQ--------WKSKTGLD---IHEAYGQTET-GMI---CGVRKG
MKIKPGSMGKA--CAPYDVQ------------IVDEEANILPPGKEGEIAI-KVKPERPV
GLFSRYI-------------------DNPDKTAATIRGDFHIT--GDRGVMDKEGYFWFV
GRNDDIINS-----------------------------SG-----Y-RIGP-FEVESALL
EHPAVAEAAAISSPDPL-RGE--------------------------------VVKAFVV
LSSGFASRDKDKLIHELQEHVKKVTAPYKYPRK--MEFVQ-QL--PK------T------
--ISGKI--------KR-NEL---RNKEWGRV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQLLMRS-------QVLR
GLCVSWTVYGSLGPR--PRHLLARTFS----R-KWG--DY-EIPKEFNFASDVMDHWARM
EKEGKRD-PLPALWWVNDKGDEIKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FQELGDLTRQTANVLTENCGLQRGDRLIIILP
RIPELWLLSVGCMRT--GLVLL--PGTIQLTAK-D--ILYRLQSSKAKGIVTYETLAPVV
DSVASDCPQLKTKVLVSE-NSRDGWLHFKTLLKA-ASIDHTCVKT---------------
------------------KVQDPLIIFFTSGTTGLPK-MTLHSSGL-ALRSCL---PSSR
---QILKLMS---SDISWCLSD------------------------PGWILSFVGTMIEP
WNAGACSF-------------------------------IRDMSQFNPETILKT----LS
KFPITCTIAASS---VYRMLLQ---FNIS-------------SYK----FPTLKHS----
----AAGGEMLLPEEFEK--------WKKATGLN---IHEIYGQSET-GLT---CAVSRG
MKIKKGSMGKA--IPPFEMQ------------IIDDKGNILPPGTEGNIAI-RIKPTRPI
GLFSGYL-------------------NNPEKTSLTELGDFYVT--GDRGTIDEEGYFWFL
GRYDDVINA-----------------------------SG-----Y-RIGP-SEVENALA
EHPAVAESAVIGFPDPI-RGE--------------------------------VVKAFVV
LTPEFRSHDPDKLVRELQQHVKKVTAPYKYPRM--VRPGR-AW----------E------
--LRDFF--------LK-SNL---VTL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----GLQALR
SFWVV---RGVH-TQVPPPPVPQKVLTDWEAI-CLG--RQ-PVPEYFNFAHDMLDMWTRL
EKA

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 710)

GDRP-SGPAFWWVDGKGAEVKW--SYEELGKQSRKAANVLGDACGLQPGDRIMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQVSRAKSIITSDSLAPHV
DAISNECPSLQAKLLVSD-TRRPGWMNFRELLQE-ASTEHSCVRT---------------
------------------KSRDALSIYFTSGTTGAPK-MVEHSHCSYGLGFLA----SAR
---QWMGLTG---SSVFWNTTD------------------------TGWVKAAWT-LFSA
WGTGSCIF-------------------------------VHEMPRVDTKVILNT----LS
SFPITNFCCVPT---IFRLLVQ---EDLT-------------RYK----FQSLKHC----
----LTGGEALNPDVREK--------WKSQTGLE---LHEGYGQSET-VST---GPAP--
---------------PIP--------------------HFLP-------FT-FTGPSGTF
C---VFQ-------------------DNPEKTAASERGDFYIT--GDRGRMDADGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVASSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPEALTQELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQRLMKF-------RVLW
GIHMS---CPGFHHA--PQHLRCQPLSGAGTL-RWN--EY-DRPEEFNFASDVLDHWTQM
EKEGKRS-PNPALWWVNDQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTRRTANVFTQTCGLQTGDRLALILP
RVPEWWLVSVGCIRT--GIIFM--PGTTQMKAK-D--ILYRLQVSGAKAIVTTDTLAPEV
ESVAPECPSLKTKLLVSD-HSREGWLDFRSLIKS-ASPDHVCIKS---------------
------------------KTLDPMVIFFTSGTTGFPK-MAKHNHGF-ALRSYF---PACR
---KLLQLKA---SDVFWCLSD------------------------TGWILATLGSLLEP
WTAGSTVF-------------------------------AHHLPQFDSKVIIET----FF
KYPITQCLAAPS---VYRMILQ---QKFT-------------SLR----FPTLEHC----
----CTGGEALLPEEQEQ--------WKRQTGIL---LYQAYGQSET-GIT---CGTLRG
MKIKPGSMGKA--IPPFDIQ------------IIDDKGNIQPPNTEGNIGI-RIKPTRPI
GLFMYYE-------------------NNPEKTAEVECGDFYNT--GDRATIDEEGYFWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDPV-RGE--------------------------------VVKAFIV
LNPGFLSRDPDELTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KR-SEL---RKKEFGQKESPSKIAPGP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRL-------RALQ
GIRKT---FRSFQAA--PWHLHCRPVTGVGVP-KWN--DF-DRPEEFNFASDVLDYWAQM
EQEGKRD-GNPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFTEVTSLTRQVANVFTQTCGLRKGDFLALILP
RVPEWYLVAVGCIRA--XXXXX--XXXXXXXXX-X--XXXXXXXXXXKAIVTIDALAPEV
DSVASECPALKVKLLVSS-HSRDGWLNLWSLMRS-ASPDHTCIKS---------------
------------------KTTDSMTIFFTSGTTGLPK-MAKHSHSL-ALRSYL---PMCR
---AVHQLKP---SDISWCVSD------------------------PGWILATVGSLLEP
WTAGSTIF-------------------------------IHLLTQFDTKVVVET----LS
KYPITHLIAAPA---VFRMILQ---QKFT-------------SLR----FPTLRHC----
----SAGGESLLPEEQEK--------WTKQTGIP---IHEIYGQSEI-GLC---CAVARG
TKIKAGSMGKA--IAPFDVQ------------IIDDNGNILPPNTEGSIGV-RIKPFRPA
GVFVCYN--------------------NPEKTAKVECGDFYNT--GDRAKMDEEGYFWFL
GRDDDVINA-----------------------------SG-----Y-RIGP-SEVENALA
EHPAVAESAVVSSPDPA-RGE--------------------------------VVKAFIV
LHPQFQSHDKQQLIKQLQEHVKAVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-DTL---RKQEYGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLKSF-------Q---
-ICKV---LQGFSLN--PTQLHRRLFSRVGAP-RWN--DH-DSPEEFNFASDVLDYWAQM
EEEGKRG-PSP

PF00501 // ENSGT00760000119178_4_Domain_0 (252, 848)

AFWWVNGQGDEIKW--SFRKLRDLTCRTANVFEQICGLQQGDHLALILP
RVPEWWLVTVGCMRT--GIIFM--PGTTQLKAK-D--ILYRIQMSRAKAIVTTASLVPEV
ESVASECPDLKTKLVVSD-HSHEGWLDFCSLIKS-ASPDHTCIKS---------------
------------------KMKDPMTIFFTSGTTGYPK-MAKHNHGL-AFRSYV---PSCR
---KLLKLKT---SDILWCMSD------------------------PGWILATVGCLIEP
WTSGCTVF-------------------------------IHHLPQLDPKVIVEV----LF
KYPITQCLAAPG---VYRMVLQ---QKTS-------------NLR----FPTLEHC----
----TTGGESLLPEEYEQ--------WKQRTGLS---IHEVYGQSET-GIS---SATLRE
MKIKRGSIGKA--VLPFDLQ------------IIDEKGNILPPNTEGYIGI-RIKPTRPL
GLFMEYE-------------------NSPENTSEVECGDFYNS--GDRATIDEEGYIWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDKD-RGE--------------------------------VVKAFIV
LNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--VTGKI--------KR-KEL---RNKEFGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----GLQVLR
SFQKF---CGVH-TQVPPLPVPQKILDSWEAI-SLG--RQ-PVPEYFNFAHDVLDMWTQL
EKTGQRP-SCPAFWWVDGKGAEVKW--SFEELGKQSRKAANVLGDACSLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVSQLTEK-D--LKYRLQVSRAKSIITSDSLAPHV
DAISSECPTLQTKLLVSD-TSRPGWLNFRELLQE-ASTKHSCVRT---------------
------------------KSQDALAIYFTSGTTGAPK-MVEHSHCSYGLGFVA----SGS
---RWMGLTG---SDIFWNTTD------------------------TGWVKAAWS-LFPT
WGIGSCLF-------------------------------VHEMPRVDTKLILNT----LS
RFPITNLCCVPT---IFRLLVQ---EDLT-------------KYQ----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VTI---CANARG
TKIKSGSMGRA--SPPYDVQ------------IVDDEGNVLPPGEEGNIGV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRGRMDADGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYSSHDPEALTRELQEHVKKVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--LSQLRCRSLSEIGAP-RWN--DY-EVPEEFNFASCILDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEIKW--SFREIADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTVDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFYGAPS---IFRMILQ---EDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------TNPALWWVNGKGDEVKW--SFRELSSLSQKAANVFTKSCGLQRGDRVVVILP
RIPEWWLIHVACIRT--GLVFI--PGTTQLTAK-D--ILYRLQASKAKCIVVSEEVAPAV
ESIASECPNLKNKVLVSP-HNWNGWLSFQELFQS-SSEEHSCFVC---------------
------------------FPIFKL------------------SSFSLFHYFST----L

PF00501 // ENSGT00760000119178_4_Domain_0 (479, 849)

FR
---HWLDLNP---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHRMAPFDTDTFLDT----LT
TYPITHICSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEH--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEXXXXXXXXX--XXXXDVQ------------IIDEKGDILPPGKEGDIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATIRGDFYVT--GDRGRMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
AHPAVVESAVVSSPDPI-RGE--------------------------------VGEHHYS
TQ--------------------------QFPI---FKF---------------Y------
--LTTVK--------TK-SRV---QDQEWGQK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MK-----TLLKCFW
SLHFP---RTFLRHS--RRSLASLVIPDFEDI-SRG--KQ-EVPEYFNFASDVLDQWTQV
EKAGKRP-PNPAFWWVNDQREEAKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGLLSRKAANVLTGPCGLQRGDKIMTVLP
RIPEWWLLNVASMRT--GIVFI--PGTSQLTAK-D--ISYRLQASKAKGIAVSDVLAPAV
DSIASECKLLKTKLIVSE-GGRDGWLNFKELLKA-APADHNCVRT---------------
------------------KSDDTLAIYFTSGTTGTPK-MVSHSHSCYGIGLTA----IGR
---RLMNLSR---SSVFWNISD------------------------PGWVKAAWCCLFTP
WINGACVF-------------------------------IHQLPVFEPTVVLNT----LA
SYPVTNFCAPPT---GYRMLVQ---HDIT-------------RYK----FMSLNHC----
----VTGGEALNPEVYEN--------WKKQTGLD---IYEGYGQTET-VAI---CANVKG
KKIKPGSMGLA--IPPYDVQ------------IIDDEGKIQPPGTEGDIAI-RIKPKRPF
CLFKQYV-------------------DNPEKTAASERGDFYST--GDRGLMDEEGYIWFV
GRSDDVINS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPV-RTE--------------------------------VVKAFEA
YQGTSRSCEKDHSSLQIPQKD---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVRR
NSRGF---CGSP-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLEGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISPECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSGDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTSVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--FPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MW--SFRELSEMSQRAANVLAGPCSLQRGDRVALVLP
RVPEWWLVTLGCMRA--GLVFM--PGTVQMKSK-D--ILYRLQASKARAIVAGDEVAHEV
DAVAADCPALRLKLLVSE-RSRDGWLDFKTLLKE-ASTTHRCVES---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLGLKSKI--DAG--
---TWTGLQP---SDLIWTISD------------------------TGWIVNILTTLLDP
WALGACVF-------------------------------IHLLPKFDPQTILKV----LS
SYPINSMVGAPL---VYRMLLQ---QDLS-------------SYK----FPHLKHC----
----FTGGETLLPDTLQN--------WKAQTGVD---IREFYGQTET-GLT---CRVSST
MTIKPGYLGTA--IPHYDVQ------------VIDDEGRVLPPGTEGDIAI-RVKPVKPV
GIFSGYV-------------------DNPKKTAANIRGDFWLL--GDRGIKDQDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALT
EHPAVAEVAVVSSPDPV-RGE--------------------------------VVKAFVV
LTPQFLSHDKDQLTRELQQHVKSVTAPYKYPRK--LEFVL-DL--PK---T---------
--VTGKI--------SR-EKL---RATEWKTSRKPQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRTFMIS-----RIPQCLQ
ILRSP---SRLFHGC--NRLLTSQIISYYDSV-NRC--EK-ELPKYFNFASDVLDEWLLL
EKDG

PF00501 // ENSGT00760000119178_4_Domain_0 (245, 849)

RRP-VNPAFWWVNDEGEEVKW--SFEELGFLSRKTANILSEACGLQRGDRVLAVLP
RVPEWWLLSIACIRA--GIVFI--PGTSQLTAK-D--ILYRLQASKAKCMITNDTLAPVV
ESILPDCQFLKTKLIVAK-GNRDGWLNLKELFAV-TSADHKCVKT---------------
------------------RNDDPMLIYFTSGSTGSPK-MVVQSHSSYGIGFAT----SSR
---HWMNLTP---SDIMWNTSD------------------------TGWVKAAWSSVFAP
WISGSCVF-------------------------------VHNMPQFKPTVIAET----LS
RYPITVFCTAPT---AYRMLVQ---HDVS-------------SYK----FMTVKHC----
----LSGGEPLNPEVMEK--------WKIQTGLD---IYEGYGQTET-VTI---CANMKG
MKIKPGSLGKA--VPPYDVR------------IIDDHGAVLPEGEEGNIAI-QVKPSRPF
CMFSEYL-------------------DNPEKTAACMTGNFYVT--GDRGIMDEEGYVWFV
GRADDIINS-----------------------------AG-----Y-RIGP-FEVESALI
QHPAVSESAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPAFASHDPEKLTHDLQQHVKKVTAPYKYPRK--VEFVQ-SL--PK------T------
--ATGKI--------QR-KVL---RNKEWGKA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----VLQALK
SSQAF---YGTY-GQSTSPPVPK-VMATWEAI-SLG--KQ-SVPEYFNFAHDMLDLWSQL
EKAGHRP-PNPAFWWVNGTGAEVKW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPEWWLIIVACMRT--GVVMI--PGISQLTEK-D--LKYRLQASRAKSIVTNDSLAPHV
DAISADCPSLQTKLLVSD-SKCPGWMNFRELLQE-ASSQHSCVRT---------------
------------------KNQDPMAIYFTSGTTGAPK-MAEHSQSSYGLGFMA----SGR
---RWVALTE---SSVFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACVF-------------------------------VHELPRVDAKTILNT----LC
RFPITTLCCVPT---IFRLLVQ---EDLR-------------RYK----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LYEGYGQSET-VLI---CANIRG
STIKSGSMGKA--CPPYDVQ------------IVDDEGNVLPPGEEGNIAV-RIRPTRPF
CFFNCYL-------------------DSPEKTAASERGDFYIT--GDRAHVDKDGYYWFI
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSHDPETLTKELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SIL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKI-FFRF----QTFRFIW
LAKPP---GQHFHRD--HQLWT-LTLADFEAI-HRC--DR-SLPKNFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKACGLRRGDRVAVILP
RIPEWWLVNVSCMRT--GLVFM--PGTVQLTAK-D--ILYRLRASKARCIVAGEEVAPAV
ESIVSECPDLKTKLLVSP-HSRNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTI----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAFGSVFSS
WLQGACVF-------------------------------VHQMTQFDPDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKTLRHC----
----VTGGEPLNPEVLER--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKR--VLPYDVQ------------IIDENGSILPPGKEGDIAL-RLKSTWPF
CFFSEYV-------------------DNPEKTAATLRGDFYVT--GDKGVMDSDGYFWFV
GRADDVIIT-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPV-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQTHVKNLTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NTL---RDQEWGRK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-ILLHY----QRFRFIW
LAKPA---GRHFHKH--PQLQTPLTLADFEAI-NRC--EK-PLPKNFNFAADVLDQWSQK
EK

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

SGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPNLKTKLLVSP-DRWDGWLNFQELLPL-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTP---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKVQTGLE---LYEGYGQTEV-GII---CANCKG
QEIKPGSMGKG--VVPYDVQ------------IIDESGNVLPPGKEGEIAL-RLESTRPF
CFFSEYV-------------------DNPEKTAATIRRNFYVT--GDRGVMDNDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPFKSSNREKLIAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKI----PRLCTLW
RNEMS---RRTFHMN--IKKLMPIQW---------G--HQ-EVPAKFNFASDVIDHWASL
EKAG

PF00501 // ENSGT00760000119178_4_Domain_0 (245, 849)

KRS-SGPALWWMNGSGEEIKW--SFRELSEISKQTANILSGACGLHRGDRVAVVLS
QIPEWWLMILGCMRT--GLVFM--PGTIQLKSS-D--IRYRLQASKARAIVAGDEVAQEV
DAVAPDCSFLKIKLLVSE-NNREGWLNFKALLKD-ASSIHQCVET---------------
------------------GSQESAAIYFTSGTSGPPK-MAEHTHCSLGIKAKM--DAA--
---GWTDLGT---SDIVWTISD------------------------TGWILNILAAFLEP
WTLGACIF-------------------------------VHLLPKFDPQTVLKV----LS
SYPINSLVGAPL---IYRMLLQ---QDLS-------------SYK----FPHLHSC----
----FSGGETLLPETLES--------WKAKTGLE---IREFYGQTET-GLT---CRVSRT
MKVKPGSLGTP--FAHYDVQ------------VIDEQGDVLPPGKEGDIAI-RVKPTWPI
GMFSGYV-------------------DNPKKTQGNIRGDFWLL--GDRGIKDPDGYFHFI
GRTDDIINS-----------------------------SGACFCRY-RVGP-SEVENALM
EHPAVVETAVISSPDPI-RGE--------------------------------VVKAFVV
LAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--ITGKI--------ER-AKL---RAKEWKTSGQA-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------EKFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNSQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 880)

SFRELTDFTCRAANVFTQTCGLQQGDRLALILP
RVPEWWLVAMGCIRT--GIIFI--PGTTQLKAK-D--ILYRLKQSNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFRSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-SLRHSF---PSSR
---EVLQLKA---SDVLWCLSD------------------------PGWILAVMGAVFEP
WTAGSTVF-------------------------------IHHLPQFDPKVIVET----LF
KYPITQCIAAPS---VYRMILQ---ENFG-------------SLR----FPTLEHC----
----TTGGEAMLPEEQEK--------WRQRTGLL---VHQVYGQSET-GLT---CGTPRE
SQVKPGSMGKA--IPPFDVQ------------IIDDEGNILPPNTEGNLGI-RIKPTKPI
GLFMLYE-------------------NDPAKTAKVECGDFYNT--GDKATIDEEGYIWFL
GRDDDIINA-----------------------------SG--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LTKPP---GRHFHKD--RQLWTPLTLADFEAI-NRC--NR-PLPENFNFAADVLDQWAQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDHVAVILP
RIPEWWLVNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
ESIALECPDLKTKLLVSP-QSRTGWLSFQELFQF-ASEEHSCVET---------------
------------------RSQEPMTIYFTSGTTGSPK-MAQHSQSSLGIGLTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHQMAQFDTDIFLDT----LT
TYPITTLCSPPT---VYRMLVR---KDLK-------------RYK----FKSLRHC----
----LTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RRE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVE-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MGLWLRGV-----VLRALR
SSRGF---CASH-GRLPPPPVPQKVVSTWEAI-NQG--RQ-PVPEYFNFAHDVLDTWSQI
EKAGHRP-PNPAFWWVGATGAEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGKQSRKAANVLGDACGLQPGDRMMLVLP
RLPEWWLISVASMRT--GVVVI--PGVSQLTEK-D--LKYRLQASRAKCIITDDSLAPRV
EAISTDCPSLQTKLLVSD-SSRPGWMNFRALLRE-ASAEHSCLRT---------------
------------------QSRDSLAIYFTSGTTGAPK-MVEHSQCSYGLGFVT----CGR
---QWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITNLCCVAT---VYRLLVQ---EDLT-------------RYK----FQSLRHC----
----SSGGEALNPDVREK--------WKLQTGLE---LLEGYGQSET-VLI---CANLKG
TPIKSGSMGKA--VPPYDVQ------------IVDDEGNILPRGEEGNIGV-RVRPIRPF
CFFNHYL-------------------DNPEKTAATEKGDFYIT--GDRAYMDEDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPEYSSHDPEALTRELQDHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LAKPP---GRHLHRD--HQLWTHLTLADFEAI-HRC--ER-SLPKNFNFAADVLDQWSQK
EKTGERP-VNPALWWVNGKGDEVKW--SFRELSSFSQKAANVLTKPCGLQRGDRVAVILP
RIPEWWLLNVACIRT--GIIFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPVV
ESIAVECPDLKAKLLVSS-QSRNGWLSFQELFQL-ASEEHSCVET---------------
------------------GSEEPMAIYFTSGTTGSPK-MAQHSQSSLSIGSTL----CGR
---YWLDLKS---SDIMWNMSD------------------------TGWVKAAIGSVFSS
WLHGACVF-------------------------------VHQMVQFDVDTFLDT----LT
TYPITILCSPPT---VYRMLVQ---KDLK-------------RYL----GRNLHLN----
--------------------------------------HKQYLSSQQ-GII---CSNQKG
QEIKLG--------------------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (759, 849)

MYLPPGKKGK-CL-RLKSTRPL
LF--SLN-------------------DNPEKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VDELSHN
---------------------------IFLSIR--WNFVQ-EL--PR------H------
--ITGKI--------NA-TF----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTISD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRWLWKL----ERLCTLR
APGIS---TRPLHVS--VRQRTSVPW---------G--HQ-EVPAKFNFASHVIDLWASM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 378)

KAGKRP-PGPALWWVNGKGDEVKW--TFRELSEMSQQAANVLLGPCSLQRGDRVAVVLP
QVPEWWLVTLGCMRA--GLVFM--PGAIQMKSK-D--ILYRLQASKARAIVAGDEVAHEV
DAVASDCPALRLKLLVSE-RSRDGWLDLKTLLK---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

MLMPVSISGEPRTSERQAASSSKGVQSSSIDRLQGAAGEIDFSQTYTDGERGARRARSTQ
ALHTAWQQPYSKRQGTERSRLESLGSAGKQVNETESKTLNFVSVYNLFISPSGHPELSFE
DPTESMHQWTPEVTP------------AQIP-AIRQKVTEDMRLWLRGL-----VYQARR
SSWGV---FRIH-TQPPPPPIPE-VVATWEAI-SLG--KR-PVPEYFNFAHDVLDVWSQL
EKTGH

PF00501 // ENSGT00760000119178_4_Domain_0 (246, 849)

RP-PNPAFWWVNGSGTEVKW--TFEELGKQSRKAANILEGACGLKPGDRLMLVLP
RLPEWWLTIVACMRT--GVVMI--PGISQLTQK-D--LKYRLQAARVKSIITSDALAPHV
DAISADCPSLQSRLLVSD-TSRPGWINFRELLRV-ASPEHNCLRT---------------
------------------RSGDSMAIYFTSGTTGTPK-MVEHSQCSYGLGFVA----SGR
---RLMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WANGACVF-------------------------------VHELPQVDAQTILNT----LC
RFPITTICCVPT---LFRLLVQ---EDLT-------------RYK----FQCLRHC----
----LAGGEALNSDVRDK--------WKNQTGLE---IHEGYGQSET-VLI---CGNFRG
STIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAI-RIKPTRPF
CLFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDEDGYFWFV
GRNDDVIN

ENSGT00760000119178_4_Linker_0_2 (849, 894)

S-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_2 (894, 921)

EVESALA
EHPAVLESAVVSSPDPI-RG

ENSGT00760000119178_4_Linker_2_3 (921, 1060)

EKNLEVNAIGIGKELPPGLYILWELVLASNGAIVVKAFIV
LSPAYVSHDPEALTRELQEHVKTVTAPYKYPRK--DTCHF-LL--HE------G------
--IWKPMTYINFITSLQ-ILT---LNQEFSNESLLPNPM

PF02994 // ENSGT00760000119178_4_Domain_3 (1060, 1245)

GERAQCPDSNTEC-----PNT
PEKQDLD----LKSHLIMMMKDIQNSLREMQENTNEQVEAYRQEMQKIPQRIIGKHNQTG
EGIKNGNRSNKAQRETILDIENQRKRQGAVDTSITNKMKEIEDRISGAEDSIEIIDTTVK
DNGKWKKTLAQNIQEIQDTMRRSNLRIIGIEESEESQLKEPVNTSTKS

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MKLWLKGL-----ALRALR
SPWGV---CGVH-GQPPPPPAPE-ITATWEAI-NLG--RQ-PVPEYFNFAHDVLDVWSQL
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGHRP-SNPAFWWVGGTGKEIKW--SFEELGKQSRKAANVLESACGLQSGDRMMVVLP
RLPEWWLVTVACMRA--GLIMI--PGISQLTEK-D--LKYRLQASRAKSIITSDALVPQV
DAICHDCPSLQTKLLVSD-NSHPGWMNFRELLQK-ASSEHNCVRT---------------
------------------KSQDPLSIYFTSGTTGNPK-MVEHSHSSYGLGFVA----SGR
---HWVALTE---SSIFWNTTD------------------------TGWVKAAWT-FFSA
WSNGSCVF-------------------------------VHELPRVDTKLILNT----LS
RFPITSLCCVPT---LFRLLVQ---EDLT-------------RYQ----FPSLRHC----
----VTGGEALNPDVRER--------WKSQTGLE---LHEGYGQSET-VVI---CANQKG
MMIKTGSMGKA--FPPYDVQ------------IVDDQGNVLPPGEEGNVAV-RIKPTRPF
CFFHHYV-------------------DNPEKTAASEQGDFYIT--GDRAFMDKDGYFWFL
GRSDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYSSHEPEALTRELQEHVKKTTAPYKYPRK--VEFIS-EL--PK------T------
--VSGKI--------QR-GKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MTD

PF00501 // ENSGT00760000119178_4_Domain_0 (275, 910)

LTCRVANVFSQTCGLQPGDGLVLLLP
RVPEWWLVTVGCIRT--GIIFM--PGTTQMRAR-D--ILYRFQVSKAKGVVTTDALAPEV
DSVASECPALKVKLLVSD-HSHKGWLNFSSLIKS-ASPEHTCIKS---------------
------------------KTMDPMAIFFTSGTTGYPK-MAKHSHGL-ALRSSL---PSCR
---KWLQLKT---SDIIWCLSD------------------------PGWILAVLGALLEP
WTAGSTLF-------------------------------IHHLPQFDPKVIVQTLF----
KYPVTLCFGAPA---VYRMILQ---QNFP-------------SLR----FPTLEHC----
----VTGGEPLLPQEQEK--------WRRQTGVQ---LSEAYGQSEA-GIT---CGIYRG
MKIKPGSMGKA--IPPIDMQ------------IIDDKGNILPPNTEGNIGI-RIKPIRPI
GLFLGYA-------------------GDPKKTAEVECGDFYNT--GDRATMDAEGYFWFL
GRSDDVINA-----------------------------SG-----F-RIGP-AEVEDALA
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAPPFLSHDRDKLTKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-SEL---RRKEFGQMQSTTKP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWLRKL----QGLRALW
GTQMP---SHALHIN--NRQLVSVQW---------G--HL-EVQPTFNFARDVIDHWAEM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KVGKRP-PDPALWWVNGNGEEVMW--NFRELSEISQQAANVLSEACGLQRGDRVAVVLP
QVPEWGLVILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVFQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLKE-ASTTHRCVVT---------------
------------------GSQEPSAIYFTSGTSGLPK-MAEHSHSSLGLKAKL--DAG--
----WTGLQA---SDVAWTIAD------------------------TGWIVYIACSL-ES
WATGACTF-------------------------------VRLLPKFDPLVILKT----LS
SYPVKTMLTAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGETLLPEILGN--------WKAQTGLD---IREFYGQTET-GLT---CRVSKT
MKIKPGYLGTA--IPNYDVQ------------VIDDKGNVLPPGEEGDIGI-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDQGIKDEDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVEAAVISSPDPI-RGQ--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------S------
--VTGKI--------QR-AKL---RDKEWKKSGQARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLTRL-------RVVL
AIHKS---CPSFHPA--PWHLHCRPLSGPTGP-IWD--DK-NTPKEFNFARDVLDYWTQM
EKXXXXX-XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX

PF00501 // ENSGT00760000119178_4_Domain_0 (313, 910)

XXX--XIVFM--PGTTQMTAK-D--ILYRLQESGAEGIVTTDTLAPQV
DAVASQCPSLKTKLLVSD-HRREGWLDFHSLVRS-ASPDHTCITS---------------
------------------KTMDPMAIFFTSGTTGLPK-MTKHSHGL-ALRSCH---PSCR
---QHLQLKA---SDVLWCMSD------------------------PGWILATVGALTEP
WTAGATLF-------------------------------IHELSRFDPNIVIQT----LL
KYPITQCLSAPS---VYRMILQ---QNLS-------------SLQ----FPALEHC----
----GTGGEAVLPEELEQ--------WKKLTGLL---LHEAYGQSET-GLL---CGVLRG
MKIKPGSLGKA--ILPFDVQ------------IIDDKGNILPPNTEGNIGV-RIKPTRPI
GLFMCYE-------------------NDPVKTAAVECGDFYNT--GDRATMDEEGYIWFL
GRNDDIINA-----------------------------SG-----Y-RVGP-AEVENALA
EHPAVAESAVVSSPDPA-RGE---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQLLMRS----QVLRGLW
VSWPT------HPFAPSQLLAQPY--SRTEIP-QWG--DY-EIPKEFNFASDVMDHWERM
EKEGKRG-PLPALWWVNDKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFQELGNLTRQVANVLTETCGLQQGDRLCLILP
RIPDLWLVTVGCMRA--GLVYL--PGTIHLTAR-D--ILYRLQSSKAKCIVTNETMAPAV
DSVASDCPQLKSKLLVSN-NSRDGWLDFKTLLXX-XXXXXXXXXX---------------
------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX------XX
---XRKSNIQ---SDILWCMSD------------------------PGWIISW--SVMEP
W-------------------------------------------KSGACTFIHD----MP
QFNTETILKXXX---XXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXGLTCAVSRGME---IKKGSMGKVV-P-----------
---------------PFDVQ------------XXXXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXX-------------------XXPEKTSLSERGDFYIT--GDRGTVDEDGYFWFL
GRSDDIIKA-----------------------------SG-----Y-RIGP-SEVENALA
EHPAVAESAVIGSPDPL-RGE--------------------------------VVKAFVV
LTPEFRSHDPGQLVQELQQHVKKVTAPYKYPRK--VEFVT-AL--PK------T------
--STGKI--------KR-SEL---RKN---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRFWQRGL-----VLQALR
SSWGI---RRIH-RQPPPPPVPK-VVATWEAI-SLG--KQ-PVPEYFNFAHDVLDEWSRL
EKEGHRP

PF00501 // ENSGT00760000119178_4_Domain_0 (248, 849)

-PNPAFWWVNSLGAEVKW--TFEELGKQSRKAANILEGVCGLQPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGVSQLTAK-D--LKYRLQTARAKSIITSDALAPQV
DTISADCPSLQTKLLVSD-TSRPGWINFRELLRN-ASTEHNCVRT---------------
------------------KSQDSLAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITVMCCVPT---LFRLLVQ---EDLT-------------RYK----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRD
SPIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------ENPEKTASSEKGDFYIT--GDRARKDKDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYASHDPEALTQELQEHVKTVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLSQV----QLFS---
LVR-CSRLGCGPCCQPKRKFAAQT-I-KYSGS-RLL--GQ-AVPQHFNFATDVLDQWSQL
EKDGLRG-PYPALWEV

PF00501 // ENSGT00760000119178_4_Domain_0 (257, 846)

DAKGEEDKW--SFERMACLSQKAASILSDTCALGRRDQLMIILP
PTAETYWICLACVRL--GITFV--PGTPQLTAK-E--ILYRLRMTRAQGIVANETMAPVV
DSVMSDCPALKTKLLVSD-QSYDGWLNFRELIQV-APPKQTFMGT---------------
------------------KSQDPMAIFFTNRTMGAPK-LVEYSQYGLGMEFSQ----ASR
---RWMDLQP---TDVLWSLGDIF-----------------------GG-TLSLSTVLGA
WLQGACVF-------------------------------LYHMPTFCPEAVLNA----LS
RFPVTTLSGKPG---MYQELLQ---HKHFAS------------YR----FKSLKHC----
----VAAGGSISPGQIED--------WKRITNLD---IYEGYGQTET-GLL---CATSKR
MKLKPGSLGKP--LPPYIVQ------------IVDENSNILPTGEEGNIAV-CITLNQPA
SVYCPHM-------------------VSWEEYASARSQMLYLT--GDRGIMDEDGYFWLT
GRADGVANA-----------------------------LR-----H-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLKKF-------QFSW
GIFKF---FHSSSPS--SSQQHSASTSGAGTQ-RWK--DY-DSPEEFNFARDVLDYWAQM
EEEGKRG-PGPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 848)

WVNSQGDEIKW--SFRELRDLTRRTANVFEQTCGLKQGDRLALILP
RVPEWWLVTVGCFRT--GIVFM--PGTTQLKAK-D--ILYRLQTSQAKAIVTTGSLVPEV
DSVASECPTLKTKLVVSD-HSHEGWLNFRSLIKS-VPPDHTCVKS---------------
------------------KMKDPMAIFFTSGTTGFPK-MAKHNQGL-AFRSCV---PSCR
---KLLNLKT---SDILWCMSD------------------------PGWILATVGAMIEP
WASGATIF-------------------------------IHHLPQFDPKVIVEV----LF
KYPITQCLAAPA---VYRMILQ---QKIT-------------NLR----FPSLEHC----
----TTGGESLLPEEYKQ--------WEQRTGIL---IHEIYGQSET-GIS---CAVSRE
MKVKRGSIGKA--ILPFDIQ------------IIDEKGNILPPNTEGYLGI-RIKPTRPL
GLFVEYE-------------------NSPEKTAEVECGDFYNS--GDRATVDEDGYFWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-TEVENALA
EHPAVAESAVVSSPDLN-RGE--------------------------------VVKAFVV
LTPEFLLHNQEQLTKDLQQHVKSVTAPYKYPRK--VEFVA-EL--PK------T------
--VTGKI--------KR-KEL---RLKEYSQRR---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLRC----QRLRFIW
LAKPA---GRHFHRD--PQLWAPLTLDDFEAI-NRC--EK-PLPKNFNFAADVLDQWSLK

PF00501 // ENSGT00760000119178_4_Domain_0 (241, 849)

EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIASECPNLKTKLLVSP-HRWDGWLSFQELLQS-ASEEHNCVQT---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFNTDTFLDT----LT
SYPITTLCSAPT---VYRMLVQ---QDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANRKG
EEIKPGSMGKG--VVPYDVQ------------IIDEHGNILPSGKEGEIAL-RLGSDRPF
CFFSEYV-------------------DNPEKTDATIRRNFYIT--GDRGVMDDDGYLWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPFKSSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHM-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQRLMKF-------RVLW
GIHMS---FPGFHHA--PQHLRCRSLSGAGTL-RWN--DY-DRPEEFNFASDVLDHWTQM
EKEGKRS-PNPALWWVNDQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFREMTDLTCRTANVLTQTCGLQTGDRLALILP
RVPEWWLVCVGCIRT--GIIFM--PGTTQMKAK-D--ILYRLQVSGAKAIVTTDTLAPEV
ESVAPECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPDHICIKS---------------
------------------KTLDPMAIFFTSGTTGFPK-MAKHSHGF-ALRSYF---PACR
---KLLQLKM---SDVFWCLSD------------------------TGWILAALGSLLEP
WTAGSTVF-------------------------------AHHLPQFDPKVIIET----FF
KYPITQCLAAPS---VYRMILQ---QNYT-------------SLR----FPTLEHC----
----CTGGEALLPEEQEQ--------WKRQTGVL---LYQAYGQSEA-GIS---CGTLRG
MKIKPGSMGKA--IPPFDIQ------------IIDDKGNIQPPNTEGNIGI-RIKPTRPI
GLFMYYE-------------------NNPEKTAEVECGDFYNT--GDRATIDEEGYFWFL
GRSDDVINA-----------------------------SG-----Y-RVGP-AEVENALA
EHPAVAESAVVSSPDPV-RGE--------------------------------VVKAFIV
LNPEFSSRDPGELTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------KR-SEL---RKKEFGQK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--EGKRG-LNPAFW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 848)

WVNGQGDEVKW--SFREMGDLTRRVANVFTQTCGLQQGDHLALMLP
RVPEWWLVAVGCMRT--GIIFI--PASILLKAK-D--ILYRLQLSKAKGIVTIDALASEV
DSIASQCPSLKTKLLVSD-HSREG---------S-ASPEHTCIKS---------------
------------------KTLDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PGSR
---KLRSLKT---SDVSWCLSD------------------------SGWIVATIWTLLEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQT----LL
KYPINHFWGVSS---IYRMILH---QDFT-------------SIR----FPALEHC----
----CTGREVVLPKDQEE--------WKRRMGLL---LYENYGQSET-GLI---CATYWG
MKIKPGFMGKA--TPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFMCYE-------------------GDPEKTAEVECGDFYNT--GDRGKMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-QRE--------------------------------VVKAFIV
LTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK--VSEGR------W------K------
--GSGDS--------IT-VDL---RKKETGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVLR
NSRGF---CGSR-GQPTPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EEAGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--VPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----VCQALR
SSWGV---CRIH-TQPPPPPIPE-VVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKTGH

PF00501 // ENSGT00760000119178_4_Domain_0 (246, 849)

RP-PNPAFWWVNGSGTEVKW--TFEELGKQSRKAANVLQGVCGLQPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGVSQLTAK-D--LKYRLQAARAKSIVTSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRA-ASPEHNCVRT---------------
------------------RSGDSVAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTLCCVPT---LFRLLVQ---EDLT-------------RYK----FQCLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRH
STIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDEDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYASHDPEALTRELQEHVKTVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------FIMRTFIKS-----CIPQCLW
ILGSP---SRTFHGN--NRLLTSQIISHYESI-NQG--KK-ELPEYFNFASDVLDEWARL
EKDGRKP-ANPAFWWVNEEGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGSLSRKAANVLSEACGLQRGDRVLAVLP
RVPEWWLLNVACMRA--GIVLI--PGTSQLTAK-D--ISYRLQVSKAKCIVTNDTLAPAV
ESVLPGSQFLKSKLIVGQ-GSRDGWLNFKELLVV-ASVDHKCVKT---------------
------------------RSQDPMVIYFTSGTTGFPK-MVVQSHSSYGIGFAI----SGR
---YWLNLTP---SDIMWNTSD------------------------TGWVKAAWSSVFSP
WICGSCVF-------------------------------VHNMPQFKPEVIAET----LS
KYPITTFCTAPT---AFLMLVQ---HDVS-------------SYK----FLSLKHC----
----TTGGEALNPEVFAK--------WKIQTGLD---IHEGYGQTET-VAI---CANMKG
MKIKPGSLGKA--VPPYDVQ------------IVDDRGAVVPRGEEGTIAV-RVQPTRPF
CLFSEYL-------------------DNPEKTAASVCGDFYLT--GDRGVMDEEGYVWFV
GRADDIINS-----------------------------AG-----Y-RIGP-FEVESALI
EHPAVSEAAVVSSPDPV-RGE--------------------------------VVKAFIV
LAPAFVSHDPEKLIHELQQHVKKVTAPYKYPRK--VEFVQ-DL--PK------T------
--VTGKI--------QR-NVL---RSKEWAK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QLFS---
LAQ-CFRLGFGACCYPNRKFPAQT-I-RPPDL-RSL--GQ-AVSQHFNFAKDVLDQWSQL
EKDGLRE-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 846)

EVSAKGEEDKW--SFESMTQLSKKTASILSDTCALSHGDRLMIILS
STPEAYWICLACVRL--GITFV--PVSPKLTAK-K--IRYQLHMSKAQCIVADEAMAPVV
NSAVSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTCVRT---------------
------------------NSQDLMAIFFTKGTTGAPK-MVGYSQYGLGMELSQ----TSR
---RWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSNVLGA
WLQGACLF-------------------------------VCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYHELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVIED--------WKRTTKLN---IYEGYGQTET-GLL---CATSKI
IKLKPGSLGKP--LPPYIVQ------------IVDENSNVLPLGEEGNIAV-RIKQNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWLS
GRADDAANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQALR
NSRAF---CGSR-RQPAHLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EEAGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLGGACSLQPGDRMMLVLP
RLPEWWLVSVACMRT--GTVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISAECPSLQIKLLVSD-SSRPGWLNFRELLRE-ASTEHNCVKT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---QWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILN-------
------------------------------------------------------------
------------------------------------------------VVV---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFV
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPAYSSHDPEALVRELQEHVKRVTAPYKYPRK--VVFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQLLLRF----QQNRVLW
ASWLS---CYPLHLH--PRQMVQQAFL-------GA--RNPEMPEKFNFANNVLDHWAHM
EKEGKKA-LTPALWWVNDKGNEVKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

YQELCDYTRQAANVLSDACGLQRGDRVIVILP
RIPEWWLAITSCIRA--GLVFI--PGTTMLVTK-D--ILYRLQTSKAKCIITNEALAPIV
DAVAPDCPALKVKLLVSE-NKRDGWMDFKTLLRE-ASTVHNCVET---------------
------------------SCAEAMAIYFTSGTTGAPK-MAEHSHGSLGFKSKL--DARER
---SWINLQP---SETTWCITD------------------------TGWILNILGTFLEP
WIFGACSF-------------------------------IHHLKKMDPMIIINT----LS
RYPINVMIAPPM---LYRMLLK---QDLT-------------SYK----FQSLHSC----
----VSSGETLLPETLQK--------WERQTGLN---IKEIYGQTET-GIL---CRSSI-
KESKPGFMGKA--VSTYDVQ------------IIDDNGNVLPPGTKGEIGV-RIKPIKPI
GFFSGYV-------------------DNAEKTAANITENFWRT--GDIGIMDKDGNFQYI
GRADDVINS-----------------------------RG-----Y-RIGP-SEVENVLN
EHPAVVESAVISSPDAN-QGE--------------------------------VVKAFVV
LTPKFESHDRDELIRELQQHVKTSTAPYKYPRK--VEFVS-VL--PK------T------
--VTGKI--------QR-AKL---RKDEWKHTTRTHGVLTSQ------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------YK----

PF00501 // ENSGT00760000119178_4_Domain_0 (650, 849)

FPHLHSC----
----FSGGETLLPETLEN--------WKAKTGLE---IREFYGQTET-GLT---CRVSRT
MKVKPGYLGTA--FAHYDVQ------------VIDEQGNVLPPGKEGDLAI-RVKPIRPI
GMFSGYV-------------------DNPKKTQDNIRGDFWLL--GDRGIKDPEGYFHFI
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVSETAVTSSLRCF-RST---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLHC----QRLRFIW
LAKPA---GRHFHRD--SQLWAPLTLDDFEAI-NRC--EK-PLPKNFNFAADVLDQWSLK
EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCSLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPSLKTKLLVSP-HHWDGWLNFQELLQS-ASEEHNCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQGSLGIGYTL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFDTDIFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKMQTGLE---LYEGYGQTEV-GII---CANRKG
EAIKPGSMGKG--VVPYDVQ------------IIDENGNILPSGKEGEIAL-RLKSDRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDDDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPYKCSNREKLTTELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----VCQALR
SSWGV---CRIH-TQPPPPPIPE-VVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKTGLRP-PNPAFWWVNGSGTEVKW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGVSQLTAK-D--LKYRLQAARAKSIVTSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRA-ASPEHNCVRT---------------
------------------RSGDSVAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTLCCVPT---LFRLLVQ---EDLT-------------RYK----FQCLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRN
STIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDEDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYASHDPEALTRELQEHVKTVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
--------------------------------------------MTTGSLDLPFVGS---
------HRWI-----------------K-------WTTASLTMHHLWKI----PRLFTLW
GNEIS---CCTFHMN--IKKLIPIQW---------G--HQ-EAPAKFNFASDVIDHWASI
EKAG

PF00501 // ENSGT00760000119178_4_Domain_0 (245, 849)

KRS-SGPALWWMNGSGKEIKW--SFQELSEASKQTANVLSGACGLHRGDRVAVVLP
RIPEWWLMILGCMRT--GLVFM--PGTIQMRSS-D--ILYRLQASKARAIVAGDEVAQEV
DAVAPDCSFLKIKLLVSE-NSREGWLNFKALLKE-ASTIHQCVET---------------
------------------ESQESAAIYFTSGTSGPPK-MAEHSHCSLGIKAKM--DAA--
---SWTGLST---SDIIWTISD------------------------TAWILNILGAFLEP
WVLGACIF-------------------------------VHVLPKFDSQTVLKV----LS
SYPINCLVGAPI---VYRMLLQ---QDLS-------------SYK----FPHLHSC----
----FSGGETLLPETLEN--------WKAKTGLE---IREFYGQTET-GLT---CRVSRT
MKVKPGYLGTA--FAHYDVQ------------VIDEQGNVLPPGKEGDIAI-RVKPIWPI
GMFSGYV-------------------DNPKKTQDNIRGDFWLT--GDQGIKDPEGYFHFI
GRSDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVSETAVISSPDPS-RGE--------------------------------VVKAFVV
LAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRK--VEFVL-DL--PK------T------
--VTGKI--------ER-AKL---RAKEWKTSGQA-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLHIN--TRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PSPALWWVNGKGKELIW--NFRELNEISQQAANVLSEACGLQRGDRVAVVLP
RVPEWWLLILGCIRA--GLVFM--PGTIQMKST-D--ILYRLQMSKAKAIIAGDEVIQEV
DTVASKCPSLRIKLLVSE-KSWDGWLNFKKLLNE-ASTTHRCVET---------------
------------------GSHETVAIYFTSGTSGLPK-MAEHSHSSLGLKAKM--DAG--
----WTGLQG---SDIMWTIAD------------------------TGWILNIITSLLET
WTVGACTF-------------------------------VHLLPTFDPLIILKT----LS
SYPIKSMIGAPL---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LSGGDSLLPEILEN--------WRAQTGLD---IREFYGQTET-GLT---CVVSKT
MKIKPGYMGIA--APHYDVQ------------VIDDKGNVLPPGTEGDIGV-RVKPIKPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDKDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVISSPDPV-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------T------
--STGKI--------QR-TKL---RDKEWKMSGKARAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKI----PRYCAHW
GTGMF---SRTFHIN--IKKQMSIQW---------G--HQ-EVPAKSNFASDVIDHWANM
EKAGKRP-PRPALWWVSGSGQEVKW--NFRELSDISQQAANVLSGACGLQRGDRVAVVLP
QVPEWWLVTLGCFRT--GIVFM--PGTIQMKSS-D--ILYRLQTSKARAIVAGDEVAQEV
DAVAPECPFLKVKLLVSE-KRREGWLNFKALLKD-ASTTHHCVET---------------
------------------GSHESAAIYFTSGTSGPPK-MVEHSHSSLGIKGKM--DAG--
---TWTGLDV---SDTIWTISD------------------------TGWIVNILASFLEP
WSLGACTF-------------------------------VHLLPKFDPQTVLKV----LS
NYPINSMVGAPL---IYRMLLQ---QDLS-------------SYK----FPHLHSC----
----FTGGESLLPETLED--------WKAKTGLD---IREFYGQTET-GLT---CRVSRT
MTVKPGSLGTA--VPHYDVQ------------IIDEHGNVLPPGKEGDIAI-RVKPIRPV
GIFSGYL-------------------ENPKKTEANIRGDFWLL--GDRGIKDSEGYFHFL
GRTDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVVSSPDST-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVRSVTAPYKYPRK--VEFVL-EL--PK------T------
--IMGKI--------DR-KKL---RAKEWKTSGQAQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------CSAMQWLMRL-------RVLW
GTHKS---CHAFHLA--PRTLRFPSVSATGAP-RWN--DH-DRPEKFNFASDVLDYWTQM
EKEGKRG-PNPALWWVNSQGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFRELTDFTCRAANVFTQTCGLQQGDRLALILP
RVPEWWLVAIGCIRT--GIIFM--PGTTQLKAK-D--ILYRLKQSNAQSIVTTDALAPEV
DSVASECPALKTKLLVSD-HSREGWLDFQSLIQS-ASPDHTCIKS---------------
------------------KTTDPMVIFFTSGTTGFPK-MAKHSHGL-ALRHSF---PSSR
---EVLQLKA---SDVLWCLSD------------------------PGWILAAVETMIEP
WTAGSTVF-------------------------------IHHLPQFDPKVIVET----LF
KYPITQYIAASS---VFRMILQ---ENFG-------------RYV----FPTLEHC----
----STGGEAVLPEEQEK--------WRQRTGLL---LHQIYGQSET-GLT---CATPRG
SQVKPGSMGKA--IPPFDVQ------------IIDDKGNILPPNTEGNLGI-RIKPTKPI
GLFMLYE-------------------NDPAKTAKVECGDFYNT--GDKATIDEEGYIWFL
GRDDDIINA-----------------------------SG-----Y-RIGP-AEVENALA
EHPAVAESAVVSSPDPI-RGQ--------------------------------LVKAFIV
LTPKFLSHDPDQLAKELQEHVKAVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-NEL---REKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MMPWLRGR-----VLWVLR
NARGF---CGLR-GQQAPLPDPQKLVATWEAI-SLG--RQ-PVPEYFNFAHDVLDMWSQL
EKAG

PF00501 // ENSGT00760000119178_4_Domain_0 (245, 849)

HRQ-QIPAFWWVNGLGEEIKW--SFEELGKQSRKAANVLQGMCGLQPGDRIMLVLP
RLPEWWLVSVACIRT--GAVMI--PGVSQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISADCPSLQSKLLVSN-SSRPGWMNFRELLRE-ASTEHNCVRT---------------
------------------KSQNPMAIYFTSGTTGAPK-MVEHSQASYGLGFVA-----S-
-GRQWVDLTK---SDIFWNTSD------------------------TGWVKAAWT-LFSA
WSNGSCIF-------------------------------VHELPRVDVKVILNT----LS
RFPITTFCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----VTGGEALNPDVREK--------WKSQVGLE---LHEGYGQSET-VLI---CANLKG
MKIKAGSMGKA--FPPYDVQ------------VVDDEGNILPPGEQGNIAV-RVKPTQPF
CFFSCYL-------------------DNPEKTKATERGDFYIT--GDQAHKDKDGYFWFT
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVENALA
EHPAVLEAAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYSSQDPKKLTQELQEHVKRETAPYKYPRK--MAFVS-EL--PK------T------
--TSGKI--------QR-NIL---RRQEWGEMRGTPQKAP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VFFHY----QRFRFIW
LAKPA---GRHFHRN--HQFCTPLTLADFEAI-NRC--EK-PLPKNFNFAGDVLDQWSQK
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KSGERP-DSLALWWVTGKGDEVKW--SFRELGSLSRKAANVLTKSCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQISKAKCIVASEEVAPTV
ESVVSECPNLKTKLLVSP-QSQNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSHEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYAL----CGR
---YWLDLTS---SDVMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYN----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANSKG
QEIKPGSMGKG--VSPYDVQ------------IIDENGNILPSGKEGEIAL-RLQSTRPF
CFFSEYV-------------------DNPEKTNATIRRNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPETLTIELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------R
---Y

PF00501 // ENSGT00760000119178_4_Domain_0 (485, 774)

WLNLTP---SDVMWNTSD------------------------TGWAKSAYGSVFSP
WTCGSCVF-------------------------------VHNIPQFQPEVIAET----LS
KYPITPFCTAPT---AFRMLVQ---HDVS-------------SYK----FPSLKHC----
----ITGGEALNPEVLVK--------WKIQTGLD---IHEGYGQTET-VTI---CANMKG
MKIKPGSLGKA--VPPYDVQ------------IVDDHGAVVPRGEEGTIAV-RVQPTRPF
CLFSEYL-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRFIW
LAKPP---GRHFHRD--HQLWTPLTLADLEAI-NRY--DK-PLPKNFNFAGDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKTANVLTKPCGLQRGDRVVVILP
RIPEWWLVNVACMRT--GLVFM--PGTTQLTAK-D--ILYRLQASKAKCIVASEEVALAV
ESIVSECPHLKTKLLVSP-HARNGWLSFQELFQS-ASEEHSCVQT---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----AGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSTFSS
WLQGSCVF-------------------------------VHRMAQFDTDTFLHT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKEQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VEPYDVQ------------IIDENGNILPPGKEGEIAL-RLKSTRPF
SFFSEYV-------------------DNPEKTAATVRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MGFWLRG----AVLRALR
GSRGFC----RSPGHPSPFPVPQKLVATWEAI-NLG--RQ-PVPEYFNFAHDVLDTWSQM
EKVGHRP-PNPAFWWVGDSGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 467)

SFEELATQSRKAANVLKDVCDLRPGDKMIMVLP
RLPEWWLLSVACMRT--GVIMI--PGICQLTEK-D--LKYRLQASRAKGIITSDSLAARV
DAISADCPSLQTKLLVSD-SNRPGWINFRAHFRE-ASAKHDCVKT---------------
------------------RSQDSLAIYFTSGTTGSPK-MVEHSQSSYGLGFVT----CGX
---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX
XXXXXXXX-------------------------------XXXXXXXX-------------
---------------------X---X-XXXX------------XX----XXXXXXX----
----XXXXXXXXXXXXXX--------XXXXXXXX---XXXXXXXXXX-XXX---XXXXXX
XXXXXXXXXXX--XXXXXXX------------XXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXX-------------------ENPEKMAASEKG----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHGLWKL----RGLCTLW
GKQTS---SHTLHII--TRQVASVQW---------G--RQ-EVPAKFNFARDVIDHWADM
ETAGMRP-SSPALWWVNGKGEEVKW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FRELSEISQQASNVLSVACGLQRGDCVAVVLP
RIPEWWLVTLGCTRA--GLIFS--PGTIQMKSG-D--ILYRLQSSKAKAIVAGDEVAQEV
DMVAPKCPSLEIKLLVSE-KNRDGWLNFKTLLKE-ASTTHRCVDT---------------
------------------GSQEALAFYFTSGTSGPPK-MAEHSHSSLGLKSKM--DSG--
---FWTGLQT---SDVIWTISD------------------------TAWILNILGSFLEP
WSLGACAF-------------------------------IHHLDKFDPVVILKV----LS
SYPISSLFCAPI---VFRMLLQ---QDLS-------------SYK----FPHLKTC----
----FSAGESQLLETLEK--------WKAQTGLD---IRECYGQTET-GLT---CRVSKT
MKVKPGYIGIP--VPHYDLQ------------IIDEKGNVLPPGTEGDIGL-RVKPIKPI
GIFSGYV-------------------NNLQTVADNIRGDFWLM--GDRGIKDQDGYFQFM
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALT
EHPAVAETAVVSSPDPV-RGE--------------------------------VVKAFVV
LAPEFLSHDRDQLTKELQQHVKSVTAPYKYPRK--IEFVL-DL--PK------T------
--ITGKI--------ER-AKL---RKKEWKMSGQSRTK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLTKL----RGLCTLW
GTQRS---SRTLYLN--TRQLISIQW---------G--RQ-EVPATFNFATDVVDRWAGM
EKAGKRP-LHPALWWVDGSGAEVTW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FQDLSKISQQAANVLSGTCGLQRGDRVVVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTIQMKSA-D--ILHRLQASEARAIVAGEEVAHEV
DTVAPNCPSLRIKLLVSE-KSRSGWLNFKSLLQE-APTTHHCVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MVEHSHASLGIKAKM--DAE--
---NWTGLRA---SDTIWTISD------------------------TGWIVNILASLLEP
WALGACVF-------------------------------IHLLPKFDPVVVLKV----LS
SYPINSLVGAPL---IYRMLLQ---QDLA-------------SYK----FPHLKNC----
----FTGGESLLPDTLGS--------WRAQTGLD---IREFYGQTET-GLT---CRVSST
MKIKPGYLGTA--SPPYDVQ------------VVDDEGNVLPPGQEGDIGI-RVNPIKPI
GIFSGYV-------------------GSPKKTAANIRGDFWIL--GDRGIMDPDGYFHFM
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVVSSPDPV-RGE--------------------------------VIRNWEG
TDLKDTAHDHNQLTKELQEHVKSVTAPYKYPRK--IEFVL-DL--PK------N------
--ITGKI--------QR-TKL---REKEWKTSGQARAS----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLVRF-------RVLW
GIHKS---FHAFHPA--PSQLRCQSFSGVGAP-KWN--DH-DVPKEFNFASDVLDYWAQM
EKEGKRG-PEPALWWINTQGDEMKW--NFREMRDLSCRVANVLTQTCGLQRGDHLTLILP
RVPEWWLVAMGCIRT--GIVFM--PGTTQLKPK-D--ILYRLQMSNSKAIVTTDTLAPEV
DSVASECPTLKTKLLVSE-NSLNGWLDLRSLIKS-ASPEHTCVKS---------------
------------------KMEDPMIIFFTSGTTGFPK-MAKHNHGL-AFRSYL---PACR
---NLMQLKK---SDVLWCMSD------------------------PGWILAAVGALFEP
WTAGSTLF-------------------------------IHHMSPFDPKIIIKV----LF
KYPITHCLAAPA---VFRMVLQ---QKVA-------------NLR----FPTLKHC----
----YTGGESLLTEEFEQ--------WKKQTGIL---LREIYGQTET-GIT---CGVLQK
MKIKQGSLGKA--ISPFDVQ------------IIDNKGNVLPPNTEGNIGI-RIKPTRPV
GLFMYYE-------------------NDPEKTVEVHCGDFYNT--GDKATIDEEGYIWFL
GRSDDVINA-----------------------------SG-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALA
EHPAVAESAVVSSPDPT-RGE--------------------------------VVKAFIV
LNPPFLSHDQDQLVKELQQHVKSVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-SEL---RKKEWSDVSSSQARTARP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MR---LCVC-------------R

PF00501 // ENSGT00760000119178_4_Domain_0 (644, 769)

YK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDENGNILPPGKEGEIA----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--TSQLCCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG

PF00501 // ENSGT00760000119178_4_Domain_0 (248, 848)

-PNP-------------W--SFREMSDLTRHVANIFTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTIASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLIKS-ASPEHTCIKS---------------
------------------KTVDPMVIFFTSGTTGFPK-MAKHCHGL-ALQASF---PTSR
---KIRSLKI---SDVSWCLSD------------------------PGWILATMGTLVEP
WTAGCTAF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFFGAPS---IFRMILR---QDFT-------------SIR----FPALEHC----
----CTAGEVLWPKDQEE--------WKRRTGLP---LYDIYGQSET-GII---CATLRE
MKIKPGFLGKA--TPPYDVQ------------VIDDKGNILPPNTEGNIGI-RIKPARPV
TLFVGYE-------------------GNPEKTAEVECGDFFNT--GDAGMMDEEGYICFL
GRSDDIINA-----------------------------S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLKSF-------Q---
-IFKV---LQGFSLS--PTQLYRRLFSRVRAP-RWN--DH-DSPEEFNFASDVLDYWAQM
EEEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEIKW--SFRELRDLTCRTANVFEQICGLQQGDRLALILP
RVPEWWLVTVGCIRT--GIIFI--PGTTQLKAK-D--ILYRIQMSQAKAIVTTASLIPEM
ESVASECPDLKTKLVVSD-HSHEGWLDFWSLIKS-ASPDHTCIKS---------------
------------------KMKDPMVIFFTSGTTGYPK-MAKHNQGL-AFRSCI---PSCR
---KILKLKT---SDTLWCMSD------------------------PGWIMATLGCLIEP
WTSGSTLF-------------------------------IHHLPQFDPKVIVEV----LF
KYPITQCLAAPG---VYRMILQ---QKIS-------------NLR----FPTLEHC----
----TSGGESLLPEEYEQ--------WKKRTGLP---IHEIYGQSET-GIS---SATLRE
MKIKQGSIGKA--VLPFDMQ------------IIDKKGNILPPNTEGYIGI-RIKPTRPL
GLFMEYE-------------------NSPENTSEVECGDFYNT--GDRATIDEDGYIWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-AEVENALV
EHPAVAESAVVSSPDKD-RGE--------------------------------VVKAFIV
LNPEFLSHDQGQLIKELQHHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--VTGKI--------KR-KEL---RNKEFGQL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFSCY----QTFRFIR
LTKPP---GRRFHKD--YQLQVPLTLDDLEAI-MLC--ER-PLPKSFNFAADVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNSQGNEVKW--SFRELGSLSRKAANVLTKSCGLERGDRVAMILP
RIPEWWLLNVACMRT--GLVFM--PGTTQLTAK-D--LLYRLRASKAKCIVASDEVVPAV
ESAASECPDLKTKLLVSP-HSRNGWLSFQELFQN-ASTEHSCVET---------------
------------------GSQESMAIFFTSGTSGSPK-MAQHSQSSLGIGSTH----CGR
---HWFDLKS---SDTMWNISD------------------------TGWIKASLGSLFSP
WLMGSCVF-------------------------------VHRMAQFDTDTVLDV----LA
TYPITTLCGPPT---VYRMLVQ---KDLR-------------RYK----FKSLKHC----
----LTGGEPLNPEVLEQ--------WRAQTGLN---LYEGYGQTEV-GLI---CASYKG
QEIKPGSMGIR--APPHDVQ------------IIDENGDVLPPGKEGEISI-RLTPTRHF
SLFSKYV-------------------DNPEKTAATIRGGFYVT--GDRGVMDSDGYFRFV
GRADDVIIS-----------------------------AG-----Y-RIGP-FEVESALI
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEQLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--VTGKI--------KR-NIL---RDREWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MK-VLLHC----QRLRFIW
LAKPA---SRHFHRY--PQLWAPLTLDDFEAI-NRC--EK-PLPKNFNFAADVLDQWSLK

PF00501 // ENSGT00760000119178_4_Domain_0 (241, 849)

EKSGERP-ANPALWWVNGKGDEVKW--SFQELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTIQLTRK-D--ILYRLQASKAKCIVASEEVAPAV
DSIVSECPSLKTKLLVSP-HRWDGWLSFQELLQS-ASEEHNCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQGSLGIGYTL----CGR
---YWLDLTS---SDIMWNMSD------------------------TGWIKAAIGSVFST
WLRGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYQ----FKRLRHC----
----LTGGEPLNPEVLEQ--------WKMQTGLE---LYEGYGQTEV-GII---CANRKG
EEIKPGSMGKG--VVPYDVQ------------IIDENGNILPPGKEGEIAL-RLKSDRPF
CFFSEYV-------------------DNPEKTDATIRRNFYVT--GDRGVMDDDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFIV
LAAPFKCSNREKLTAELQDHVKNSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MIFF-RY----QMFRFIW
LAKPT---GRYLHKD--HQLWAPLTLADFEAI-NRC--ER-SLPKNFNFAGDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGAEVKW--SFEELGSLSRKAANVLIKPCGLKRGDRVAVILP
RIPEWWLINVACMRT--GLVFM--PGTTQLTAK-D--ILYRLRASKAKCVVVSEEVVPAV
ESIMSECPDLETKLLVSP-HSKNGWLSFQELFQS-ASAEHSCVET---------------
------------------GSQEPMAIYFTSGTTGAPK-MAQHSQSSLGIGYTL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFAS
WLQGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLQHC----
----LTGGEPLNPEVLEQ--------WKAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKLGSMGKG--VQPYDVQ------------IIDENGNVLPPGKEGEIAL-RLQTTRPF
CFFSEYV-------------------DNPEKTAATIRGNFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPFKSSNPEKLTLELQDHVKKSTAPYKYPRK--VEFVP-EL--PK------T------
--ITGKI--------KR-NVL---RDHEWGRT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQLLMRL-------RVLC
GIHKS---SHSFHSA--PWQLRCQSLSGHGVL-RWN--DY-DTPEEFNFASDVLDYWAQM
EKEGKRG-PNPAFWWVNNQGDEVKW--SFREMTDLTRRVANVLTQTCGLQPGDGLALILP
RVPEWWMVSVGCIRT--GIIFM--PGTTLLKAK-D--ILYRLQVSKAKSIVTTDILAPEV
DSVASECPALKTKLLVSD-HSRKGWLDFRTLVKS-ASSVHTCTKS---------------
------------------KTMDPMAIFFTSGTTGFPK-MAKHSHGL-ALHSCL---PSSR
---KLLQLKK---SDVFWCLSD------------------------SGWILAVLGSLLEP
WAAGSTVF-------------------------------IHHLPQFDPKVIVQT----FF
KYPITHCLAAPS---VFRMILH---QDFT-------------SIR----FPTLEHC----
----CTGGEALLPEEHEQ--------WKKRTGIL---LHEAYGQSET-GIS---CGVSRG
MKIKLGSLGKP--IPPYNIQ------------IIDDKGNILPPNTEGNI-----------
GLFLCYE-------------------DNPEKTAEVECGDFYNT--GDRASMDEEGYIWFL
GRGDDVINA-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVAESAVVGSPDPI-RGE--------------------------------VVKAFVV
LAPGFLSHDQDQLTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------RH-GEL---RKKEFGQV----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RTLW
GIHKS---FHNIHPA--PSQLRCLSLSEFGAP-RWN--DY-EVLEEFNFASYVLDYWAQK
EKEGK

PF00501 // ENSGT00760000119178_4_Domain_0 (246, 848)

RG-SNPAFWWVNGQGDEVKW--SFREMGDLTRRVANVFTQTCGLQQGDHLALMLP
RVPEWWLVAVGCMRT--GIIFI--PATILLKAK-D--ILY-LQLSKAKGIVTIDALASEV
DSIASQCPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTLDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PGSR
---KLRSLKT---SDVSWCLSD------------------------SGWIVATIWTVLEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQT----LL
KYPINHFCGVSS---IYRMILQ---QDFT-------------SIR----FPALEHC----
----YTGGEVVLPKDQEE--------WKRRTGLL---LYENYGQLET-GLI---CATYWG
MKIKPGFMGKA--TPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPVRPV
SLFMCYE-------------------GDPEKTAEVECGDFYNT--GDRGKMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALV
EHPAVAESAVVGSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRK--VEFVS-EL--PK------T------
--ITGKI--------ER-NEL---RKKETGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RVLC
GIHKS---FHIFHPA--PRQVGRQSSSGLRAP-RWS--DH-DTPEEFNFASSVVDYWAQM
EKEGK

PF00501 // ENSGT00760000119178_4_Domain_0 (246, 362)

RG-SETALWWVNGQGDEVKW--SFREISELTRRTANVFTQACGLQQGDHLALILP
RVPEWWLVTVGCIRT--GIVFM--PGTTQLTAK-D--IMYRLQASKAKAIVTTDTLAPAV
DSVASE------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------PL--TLDD

PF00501 // ENSGT00760000119178_4_Domain_0 (211, 910)

FE-AINRFEK-ALPKNFNFAADVLDQWSQK
EKXXXXX-XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX
XXXXXXXXXXXXXXX--XXXXX--XXXXXXXXX-XX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGSPK-MAQHSQSSLGIGYTL----CGS
---YWLDLKP---SDIIWGMSD------------------------TGWIKAAIASVFAA
WLQGACVF-------------------------------VHQMARFDTDTFLEA----LT
TYPITTLCSAPT---VYRMLVQ---KDLKR-------------YKFK----KLQHC----
----LTGGEPLNPEVLEQ--------WKAQTGLQ---LYEGYGQTEV-XXX---XXXXXX
XXXXXXXXXXX--XXXXXXX------------XXX-XXXX-XXXXXXXGEIALRLKSTWF
CFFSDYL-------------------DNPEKTAATVRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVLESAVVSSPDPV-RGE---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKL----QQVCIRW
GTQMS---SRTVHLH--TKQLTSLQW---------G--HQ-EAPEKFNFASDVIDHWAGM
EKAGKRP-PGPALWWVNGDGDEVVW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 910)

FSQLRELSQQAANVLSGACSLQPGDRVAVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQESKARAIVAGDEVSQIV
DTVASECPSLKMKLLVSE-KSRDGWLDFKTLLRE-ASTNHCCVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHASLGIKAKM--DAS--
---KWMGLQA---SDIIWTISD------------------------TAWILNILTSFLQP
WIAGACTF-------------------------------IHLLPKFDPEVILKV----LS
SYPINNMVGAPI---VYRMLIQ---QDLS-------------SYK----FPHLQNC----
----FSGGESLLTDTLEN--------WRAQTGLD---IREFYGQTET-GLT---CRVSKT
MKLKPGYLGTA--IPHYDVQ------------VLDDKGKILPPGTQGDLGI-RVKPIRPI
GIFSGYV-------------------DNPEKTAANIRGDFWIL--GDRAIKDQDDYFQYL
GRGDEIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVVSSPDPV-RGE--------------------------------VVKAFVV
LAPEFLSHDSNQLTKELQQHVKSVTAPYKYPRK--VEFVS-DL--PK------T------
--VTGKI--------QR-KIL---RDKEWKTSRQAGPQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MLVQ--

PF00501 // ENSGT00760000119178_4_Domain_0 (625, 729)

-KDLK-------------SYS----FKTLRHC----
----LTGGEPLNPEVREQ--------WKNQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMG---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLVRF-------RVLW
GVHRS---LRALHPA--PAHLGCQPLTGVGAP-RWS--DH-DMPKEFNFASDVMDYWAQM
EKEGKRG-PGPALWWISTQGEEVKW--NFRDMRDLSCRVANILTGPCSLQQGDHLALILP
RVPEWWLVALGCIRT--GIVFI--PGTTQLTSK-D--ILYRLQVSNAKAIVTTDSLAPEV
DAVASECPALKSKLLVSD-HSLHGWLDLQSLIKS-ASPEQTCIKS---------------
------------------KTEDPMTIFFTSGTTGLPK-MVKHNHGL-ALRSYL---PTCR
---KLMQLKT---SDVLWCLSD------------------------PGWILATVGALFEP
WTAGSTLF-------------------------------IHHLPQFDPKVIIKV----LF
EYPITHCIAAPT---VFRMILQ---QKVA-------------NLR----FPTLKFC----
----FTGGESLLIQEFEQ--------WKKQTGIL---LHEIYGQSES-GIT---CGVFQE
MKIKPGSLGKA--ISPFDVQ------------IIDDKGNVLPPNTEGNIGI-RIKPTKPV
GLFMYYE-------------------NNPQKTAAVECGDFYNC--GDKATMDAEGYIWFL
GRSDDLINA-----------------------------SG-----Y-RIGP-A

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVAESAVVSSPDPT-RGE--------------------------------VVKAFVV
LNPPFQSHDQDQLIKELQQHVKTVTAPYKYPRK--VEFVP-EL--PK------T------
--VTGKI--------KR-AEL---RKKEFGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRFWRRGL-----VLQALK
SSWGI---CRIH-RQPPPPPVPK-VVATWEAI-SLG--KQ-PVPEYFNFAHDVLDEWSRL
E---------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (263, 849)

-KW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPDWWLISVACIRT--GVVMI--PGVSQLTSK-D--LKYRLLASRAKSIITSDALAPKV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRE-ASAEHNCVRT---------------
------------------KSQDSLAIYFTSGTTGAPK-MVEHSQCSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTMCCVPT---LFRLLVQ---EDLT-------------RYK----FQSLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRG
STIKSGSMGKA--SPPYDVQ------------IVDEEGNILPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------ENPEKTASSEKGDFYIT--GDQAHKDKDGYFWFS
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLECAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYTSHDPEALTRELQEHVKKVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-STL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLWKL----QRICILW
GTQVS---GRTVHLH--TKQLASLQW---------G--HQ-EVPAKFNFASDVIDHWAGM
EKTGKRP-PGPALWWVSGDGDEIVW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

NFSQLRELSQQAANVLSVACSLQPGDRVAVVLP
RVPEWWLVTLGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQVSKARAIVAGDEVAQAV
DTVASDCPSLKTKLVVSE-KSRDGWLDFKTLLRE-ASTTHCCVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHSSLGMKAKM--DAG--
---LWIDLQA---SDIMWTISD------------------------TAWILNILASFLET
WTAGACTF-------------------------------IHLLRKFDPVVILKV----LS
SYPINSLVGAPI---IYRMLLQ---QDLS-------------SYK----FPHLQNC----
----FSGGETLLPDTLEK--------WRAQTGLD---IREFYGQTET-GLT---CRVSKT
MKIKPGYLGTA--IPHYDVQ------------VLDDKGKVLPPGTEGDVGV-RVKPIRPI
GIFSGYV-------------------DNLEKTAANIRGDFWIL--GDRAIKDQDGYFQYL
GRADDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVTSSPDPV-RGE--------------------------------VVKAFVV
LAPQFLSHDPDQLTKELQQHVKSITAPYKYPRK--VEFVS-DL--PK------T------
--VTGKI--------QR-KKL---RDKEWKTSRQAGAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLLKY----RGLCSLW
RPEMS---SPTFHIN--IRKWMSIQW---------G--HQ-EVPAKFNFASDVMDHWASM
EKAGKRP-PGPALWWVSGRGEELKW--NYRELSEISQQAANVLSRACGLQRGDRVAVVLS
QVPEWWLVTLGCMRT--GLVFM--PGTVQMKST-D--ILYRLQVSKARAIVAGDEVAQEV
DTVAPDCPLLRIKLLVSE-RSREGWLDFKKLLKE-ASTTHHCVET---------------
------------------GSHEAAAIYFTSGTSGPPK-MAEHSHSSLGIKAKM--DAG--
---TWTGLKT---SDTIWTISD------------------------TGWIVNILTAFLEP
WTLGACIF-------------------------------VHLLPKFDPQTALKV----LS
SYPINSMVGAPL---IYRMLLQ---QDLS-------------SYK----FPHLKNC----
----FTGGETLLPETLES--------WKVQTGLE---IREFYGQTET-GLT---CRVSWT
MTVKSGYLGTA--VPHYDVQ------------VIDEEGNVLPPGKEGDIAI-RVKPFRPV
GIFSGYV-------------------DNPNKTQANIRGDFWLL--GDRGIKDPDGYFHFI
ARTDDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPT-RGE--------------------------------VVKAFVV
LAPEFLSHDPDQLTKLLQQHVKSVTAPYKYPRK--VEFVL-EL--PK------T------
--ITGKV--------AR-GKL---RAKEWKTSGQAQAQ----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------ICKL----QTLKLLW
TLKPP---CRTFHRH--PRLLVSDVHSQYESV-RRG--EQ-EIPKYFNFASDVLDKWSEI
EKAGRKP-TNSAFWWISGNGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFLSRKVANVLTKVCGLQKGDRVIVVLP
RIPEWWLVNVACIRA--GIVLI--PGTSQLSAK-D--ILYRLQASKAKCIITNDTLAPAV
DSVASECQFLENKLVVS-KGSREGWLNFNELYKN-QPADHSCVKT---------------
------------------RIQDSMVIFFTSGTTGSPK-MTEHSQGSLGFRPLLFLFPAAR
---YWLDTSP---SDTVWGITD------------------------TGWIVTSLASLFDA
WALGSCVF-------------------------------VHQLPQIEPSVILNT----LC
RFPIDTMISAPT---LYRMLVQ---ADLS-------------SYK----FMNLKHC----
----MSGGEPLNPEVIDQ--------WKSKTGLD---IHEVYGQTEA-GII---CSVSKG
MKIKPGSMGKA--APPFDVQ------------VVDKNANILPPGQQGEIAV-RSKPVRPL
GLFTEYV-------------------DNPKKTTESERGDFYIT--GDRGTMDEDGYFWFI
GRDDDIIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVAETAVVSSPDPL-RGE--------------------------------VVKAFVV
LSDAFSSSDCESLTRDLQEHVKKTTAPYKYPRK--VEFVR-EL--PK------T------
--ITGKI--------KR-NEL---RAKEWGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRTFMIS-----WIPQYLQ
ILRSP---SRLFHGC--NRLLTSRIISYYDSV-NQC--EK-ELPKYFNFASDVLDEWLQL
EKDGRRP-ANPAFWWVNDEGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFEELGFLSRKTANILSEACGLQRGDRVLAVLP
RVPEWWLLSIACIRA--GIVFI--PGTSQLTAK-D--ILYRLQASKAKCIITNDTLAPAV
ESILPDCQFLKAKLIVAK-GNRDGWLNLRELFAV-TSADHKCVKT---------------
------------------RNEDPMLIYFTSGSTGSPK-MVVQSHSSYGIGFAT----SSR
---YWMNLTP---SDIMWNTSD------------------------TGWVKAAWSSIFAP
WISGSCVF-------------------------------VHNMPQFKPTIIAET----LS
RYPITIFCTAPT---AYRMLVQ---HDVS-------------SYK----FMTLKHC----
----LSGGEPLNPEVMEK--------WKIQTGLD---IYEGYGQTET-VTI---CANMKG
MKIKPGSLGKA--VPPYNVR------------IIDDHGAVLPKGEEGNIAI-QVQPSRPF
CMFSEYL-------------------DNPEKTAACMTGNFYVT--GDRGIMDEEGYVWFV
GRSDDIINS-----------------------------AG-----Y-RIGP-FEVESALI
QHPAVSESAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPAFASHDPEKLTRDLQQHVKKVTAPYKYPRK--VEFVQ-SL--PK------T------
--ATGKI--------QR-KVL---RNKEWGKA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRRL-----VLQALR
SSRGF---CGSR-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EEAGHRP-PNPAFWWVNGTGAEVKW--SFQELGKQSRKAANVLGGACGLQPGDRMMLVLP
RIPEWWLVSVACMRT--GAVMI--PGVTQLMEK-D--LKYRLQASRAKSIITSDSIAPRV
DAISAECPSLQTKLLVSE-SSRPGWLNFRELLRE-ASTEHNCVRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGSCIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTGVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--SPPYDVQ------------IVDDEGNILPPGEEGNVAV-RIRPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINSSRSSCLHVLSPFETSWGLREAHLKSLFFPSS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFVV
LTPAYSSHDPEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWGK-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------IIFM--LGTTQMRMR-D--ILYQLLASKAKGVL-TDTLAPEV
DSVASECPALKVKLLVSD-HRHKGGQNFPSLIKS-ASPEQTCTKS---------------
------------------KTMDLMTIFFTSGTGYTK--MAKHS-HGLDLLLP--------
--------------T----------------------------------FFG-----SDL
WSLRVFSDRDLGTTQ--DGWNIYGIWTLSYPKDIGLVVSIAHLCQVDRDILLVH----VE
PLIQGHFLVASS---AGPVMLN---SDCTVTI----FEESDQLY-----EGDEIH-F---
------------PPNQKN--------WKRIQKRIMLILENVLSSTVT-KVS---CQRWFC
KLTTS-LIERK--GQPHRIS------------VKIKRKFI-Q--------QMFTESTHMP
ELSMCAE-------------------

PF00501 // ENSGT00760000119178_4_Domain_0 (807, 910)

GDPKKTDKVECGDFYNT--GDKAGMDAEGYFWLL
GRSDDIINA-----------------------------SG-----F-RLWP-AEVEDALA
EHPAVAKSAVISSPDSI-RGE--------------------------------VVKVCIV
LALPFLSHDQDQLTKELQQHVKSVTGPYKYPRK--VSW----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MYWLRKL----QGLCTLW
GTQMP---SHTLHIN--NRQLVSVQW---------G--HQ-EVPPTFNFARDVMDHWAEM
EKVGKRP-PGPALWWVNGNGEEVMW--NFRELSEISQQAANVLSEACGLQRGDRVAVMLP
RVPEWGLVTLGCIRA--GIVFM--PGTIQLKSA-D--ILYRLQMSKAKAIVAGDEVVQEV
DAVASKCPSLRIKLLVSE-KSRDGWLNFKKLLKE-ASTTHRCVVT---------------
------------------GSQETSAIFFTSGTSGLPK-MAEHSHSSLGLKAKL--DAG--
----WSGLQA---SDIAWTIAD------------------------TGWILNIAGTF-ES
WATGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYRVKTMMCAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LTGGDTLLPEILGN--------WRAQTGLD---IREFYGQTET-GLT---CGVFKT
MKIKPGYLGTA--IPNYDVQ------------VIDDKGNVLPPGKEGDIGI-RVKPIKPI
GVFSGYV-------------------DNPEKTAANIRGDFWLL--GDQGIKDEDGYFQFL
GRADDIINS-----------------------------SG-----Y-RIGP-S

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVVETAVISSPDPI-RGE--------------------------------VVKAFVV
LASQFLSHDPEQLTKELQQHVKSVTAPYKYPRK--IEFVL-NL--PK------S------
--VTGKI--------QR-AKL---RDKEWKKSGQACAP----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLGRF----QPFS---
LVR-SFRLGFGACCYPNQKCATQT-I-RPPDS-RCL--VQ-AVSQNFNFAKDVLDQWSQL
EKDGLRG-PYPALW

PF00501 // ENSGT00760000119178_4_Domain_0 (255, 846)

KVSAKGEEDKW--SFERMTQLSEKAASILSDTCALSHGDRLMIILP
PTPEAYWICLACARL--GITFV--PGSPQLTAK-K--IRYQLRMSKAQCIVADEATAPVV
NSAMSDCPTLKTKLLVSD-KSYDGWLDFKKLIQV-APPKQTYMRT---------------
------------------KSQDPMAIFFTKGTTGAPK-MVEYSQYGLGMGFSQ----ASR
---RWMDLQP---TDVLWSLGDAF-----------------------GG-SLSLSAVLGT
WFQGACVF-------------------------------LCHMPTFCPETVLNV----LS
RFPITTLSANPE---MYQELLQ---HKCFTS------------YR----FKSLKHC----
----VAAGGPISPGVTED--------WKRITKLD---IYEGYGQTET-GLL---CATSKT
IKLKPSSLGKP--LPPYIVQ------------IVDENSNLLPPGEEGNIAI-RIKLNQPA
SLYCPHM-------------------VSWEEYASARGHMLYLT--GDRGIMDEDGYFWWS
GRVDDVANA-----------------------------LG-----Q-RL-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MRSFFHC----HLFRFIW
FTKPS---IRSFHRG--HQLWAAMTSADFEAI-NRC--DR-PLPKNFNFAGDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-TNPALWWVNGKGDEVKW--SFRELSSLSQKAANVFTKSCGLQRGDRVVVILP
RIPEWWLIHVACIRT--GLVFI--PGTTQLTAK-D--ILYRLQASKAKCIVVSEEVAPAV
ESIASECPNLKNKVLVSP-HNWNGWLSFQELFQS-SSEEHSCVDT---------------
------------------GSQEPMAIYFTSGTTGFPK-MVQHSQSSLGIGYAL----CGR
---HWLDLNP---SDIIWNMSD------------------------TGWVKAAIGSVFSS
WLRGACVF-------------------------------VHRMASFDSDTFLDT----LT
TYPITHICSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEH--------WKAQTGLE---LYECYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYDVQ------------IIDEKGDILPPGKEGDIAL-RLKSTRPF
CFFSEYV-------------------DNPEKTAATIRGDFYVT--GDRGRMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
AHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPYKSSNPEKLALDSD--HVKNHCSYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGQK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQWLMRF-------RILW
GIHKS---FHNIHPA--PSQLRCRSLSEVGAP-RWN--DY-EVPEEFNFASCVLDYWAQM
EKEGKRG-PN

PF00501 // ENSGT00760000119178_4_Domain_0 (251, 848)

PAFWWVNGQGDEVKW--SFREIADLTRRTANILTQTCGLQQGDLLALILP
RVPEWWLVAVGCMRT--GIIFM--PATIMLKAK-D--ILYRLQMSKAKGIVTTDTLASDV
DSMASECPSLKTKLLVSD-HSREGWLDFRSLVKS-ASPEHTCIKS---------------
------------------KTMDPMVIFFTSGTTGFPK-MAKHSHGL-ALQPSF---PTSR
---KIRSLKT---SDVSWCLSD------------------------SGWILATMGTLVEP
WTAGCTVF-------------------------------IHHLPQFDTKVIIQA----LL
KYPINQFYGAPS---IFRMILQ---QDFT-------------SIR----FPALEHC----
----CTGGEVLWPKDQEE--------WKRRTGLL---LYNVYGQSET-GII---CATLRE
MKIKPGFLGKA--SPPYDVQ------------VIDDKGSILPPNTEGNIGI-RIKPARPV
TLFMCYE-------------------GNPEKTAEVECGDFFNT--GDRGMMDEEGYICFL
GRSDDIINA-----------------------------SG-----Y-RIGP-AEVESALM
EHPAVAESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPQFLSHDKDQLTKELQDHVKSVTAPYKYPRK--VEFVP-DL--PK------T------
--ITGKI--------KR-KEL---QKKEKGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MKIFFRY----QTFRLIW
LTKPP---GRHFHKN--HRLWTPLTLADFEAI-NRC--NK-PLPKNFNFAADVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--SFRELGSLSRKAANVLTKPCGLQRGDRVAVILP
RIPEWWLVNVACIRT--GIVFM--PGTIQLTAK-D--ILYRLRASKAKCIVASEEVAPSV
ESIALECPDLKTKLLVSP-QSRNGWLSFQELFQF-ASEEHSCVET---------------
------------------GSQEPMTIYFTSGTTGCPK-MAQHSQSSLGIGFTL----CGR
---YWLDLKS---SDIIWNISD------------------------TGWVKAAIGSVFSS
WLCGACVF-------------------------------VHRMAQFDTDTFLDT----LT
TYPITTLCSPPT---VYRMLVQ---KDLK-------------RYK----FKSLWHC----
----LTGGEPLNPEVLEQ--------WRAQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKAGSMGKG--MLPYDVQ------------IIDENGNVLPPGKEGEIAL-RLKSTRPF
CFFSEYV-------------------DNPQKTAATIRGDFYVT--GDRGVMDSDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVVESAVVSSPDQI-RGE--------------------------------VVKAFVV
LAAPFKSYNPEKLTLELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWRRR----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRLWLRGL-----ACQALR
SSWGV---CRIH-TQPPPPPIPE-VVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSQL
EKTGHRP-PNPAFWWVNGSGTEVKW--TFEELGKQSRKAANVLEGVCGLQPGDRMMLVLP
RLPDWWLISVACMRT--GVVMI--PGVSQLTAK-D--LKYRLQAARAKSIVTSDALAPQV
DAISADCPSLQTKLLVSD-TSRPGWINFRELLRA-ASPEHNCVRT---------------
------------------RSGDSVAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWMALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WSNGACIF-------------------------------VHELPRVDAKTILNT----LC
RFPITTLCCVPT---LFRLLVQ---EDLT-------------RYK----FQCLRHC----
----LTGGEALNPDVRDK--------WKSQTGLE---LHEGYGQSET-VVI---CGNSRN
STIKSGSMGKA--SPPYDVQ------------IVDEEGNVLPPGKEGNIAV-RIKPTRPF
CFFNCYL-------------------DNPEKTAASEQGDFYIT--GDRAHMDEDGYFWFL
GRNDDVINS-----------------------------SS-----Y-RIGP-V

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LSPAYASHDPEALTRELQEHVKTVTAPYKYPRK--VAFIS-EL--PK------T------
--VSGKI--------LR-SKL---RNQEWGR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MHWLQKL----QRLYTLW
SPETS---RYPLRVT--VRQLSSIPW---------G--HQ-DVPEKFNFASNVIDHWAGM
E

PF00501 // ENSGT00760000119178_4_Domain_0 (242, 849)

KAGKRP-PGPALWWVSGDGDQVQW--NFRELSEVSQQAANVLSGACRLQRGDRVAVVLP
RVPEWWLVTLGCFRA--GLVFM--PGTVQMKSR-D--ILYRLQASKARAIVAGDEVAQEV
DAVASDCPSLRIKLLVSE-KSRDGWLDFRTLMRE-ASTTHRCVET---------------
------------------RSQEAAAIYFTSGTSGPPK-MAEHSHSSLGIKAQM--DAG--
----WTGMRA---SDIIWTVSD------------------------PGWILNLLTSVLEP
WTLGACVF-------------------------------IHLLPKFDPQTILKV----LS
SYPINNLVAAPL---VYRMLLQ---QDLS-------------RHK----FPHLQNC----
----FTGGETLLPETLEK--------WRAQTGLD---IWEFYGQTET-GLI---CRVSRT
MNIKPGRLGTA--LPHYDVQ------------VIDGEGHVLPPGQEGDMAI-RVRPTKPV
GMFLGYV-------------------DNLQKTAANIRGDFWLL--GDRGIKDEDGYFQFV
GRADDIINS-----------------------------SGTSFRRY-RIGP-SEVENALL
EHPAVAESAVISSPDPD-RGE--------------------------------VVKALVV
LAPEFLSHDRDQLTQELQQHVKSVTAPYKYPRK--MEFVL-DL--PK------T------
--ISGKI--------QR-AKL---RAREWKTSEQAR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MKSFF----QLFRFIW
FTKPP---IRSFHRH--HQLWTAMTPADFEAI-NRC--DR-PLPKNFNFAGDVLDQWSQK
EKT

PF00501 // ENSGT00760000119178_4_Domain_0 (244, 849)

GERP-ANPALWWVNGKGDEVKW--SFRELSSLSKKAANVFTKSCGLQRGDRVIVILP
RIPEWWLINVACMRT--GLVFI--PGTIQLTAK-D--ILYRLQASKAKCIVISEEVAPVV
ESVLSECPNLKNKVLVSA-HSWNGWLSFQELFQS-ASEEHSCVET---------------
------------------GSQEPMAIYFTSGTTGFPK-MAQHSQSSLGIGYAL----CGR
---YWLDLKS---SDIIWNMSD------------------------TGWIKAAIGSVFSS
WLHGACVF-------------------------------VHRMAQFDTDTFLNT----LT
TYPITHLCSAPT---VYRMLVQ---KDLK-------------RYK----FKKLRHC----
----LTGGEPLNPEVLEQ--------WKEQTGLE---LYEGYGQTEV-GII---CANQKG
QEIKPGSMGKG--VLPYNVQ------------VIDEKGNILPPGKEGDIAI-RLKSTRPF
CFFSEYV-------------------DNPEKTADTIRGDFYVT--GDKGLMDRDGYFWFV
GRADDVIIS-----------------------------SG-----Y-RIGP-FEVESALI
EHPAVVESAVVSSPDPI-RGE--------------------------------VVKAFVV
LSAPYKSSNPEKLILELQDHVKKSTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NVL---RDQEWGRI----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MKICKL----RTLKSLW
TLKPP---CRTFHGH--PRLLVSDVHSQYESV-RRG--EQ-EIPKYFNFASDVLDKWSEI
EKAGKRP-TNSAFWWISGNGEEVKW--SFEELGFLSRKVANVLTKVCGLQKGDRVILVLP
RIPEWWLVNVACIRA--GIVLI--PGTSQLSAK-D--ILYRLQASKAKCIITNDTLAPAV
DSVASECQFLKNKLMVS-KGSREGWLNFNELYKN-QPADHSCVKT---------------
------------------MIQDSMIIFFTSGTTGSPK-MTEHSQGSLGFRPLL----CER
---YWLDVAP---SNIVWGITD------------------------TGWIVTSLTSVFDA
WALGSCVF-------------------------------VHQLPQIESSVILNT----LC
SFPIDTMISAPT---LYRMLVQ---TDLS-------------SYK----FMNLKHC----
----MSGGEPLNPEVIDQ--------WKSKTGLD---IYEVYGQTEA-GII---CSISRG
MKIKPGSMGKA--APPFDVQ------------VVDKNANILPPGQQGEIAI-RSKPVRPL
GLFTEYV-------------------DNPKKTTESERGDFYIT--GDRATMDEDGYFWFI
GRDDDIIIS-----------------------------SG-----Y-RIGP-F

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVESALI
EHPAVAETAVVSSPDPL-RGE--------------------------------VVKAFVV
LSDAFSSSDCESLARDLQEHVKKTTAPYKYPRK--VEFVQ-EL--PK------T------
--ITGKI--------KR-NEL---RAKEWGQM----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MRPWLRHL-----VLQVRR
TSRGF---CGSP-GQPAPLPVPQKIVATWEAI-SLG--RQ-PVPEYFNFAHDVLDVWSRL
EE

PF00501 // ENSGT00760000119178_4_Domain_0 (243, 849)

AGHRP-PNPAFWWVNGTGAEIKW--SFEELGKQSRKAANVLEGACGLQPGDRMMLVLP
RLPEWWLVSVACMRT--GVVMI--PGVTQLTEK-D--LKYRLQASRAKSIITSDSLAPRV
DAISPECPSLQTKLLVSDSDSRPGWLNFRELLRE-APTEHNCLRT---------------
------------------KSRDPLAIYFTSGTTGAPK-MVEHSQSSYGLGFVA----SGR
---RWVALTE---SDIFWNTTD------------------------TGWVKAAWT-LFSA
WPNGACIF-------------------------------VHELPRVDAKVILNT----LS
TFPITTLCCVPT---IFRLLVQ---EDLT-------------RYQ----FQSLRHC----
----LTGGEALNPDVREK--------WKRQTSVE---LYEGYGQSET-VVI---CANPKG
MKIKSGSMGKA--FPPYDVQ------------IVDDEGNVLPPGEEGNVAI-RIRPTRPF
CFFNCYS-------------------DNPEKTAASEQGDFYIT--GDRARMDKDGYFWFM
GRNDDVINS-----------------------------SS-----Y-RIGP-VEVESALA
EHPAVLESAVVSSPDPI-RGE--------------------------------VVKAFIV
LTPDYSSHDTEALTRELQEHVKRVTAPYKYPRK--VAFVS-EL--PK------T------
--VSGKI--------QR-SKL---RSQEWRK-----------------------------
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------------------------------------------SSRY

PF00501 // ENSGT00760000119178_4_Domain_2 (887, 910)

-RIAL-AEVENALA
EHPEVAESAVASSLDPI-PGE--------------------------------VVKVFIV
MSPQFLSHDRDQLTKELQQHVKGVTAPYKHPRN--AEFVP-EL--PK------T------
--ITAKF--------KR-SEL---QKRSLGGCNRQ-------------------------
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------------------------------------------MHWLRKV----QGLCTLW
GTQMS---SRTLYIN--SRQLVSVQW---------G--HQ-EVPAKFNFASDVLDHWADM
EKAGKRP-PSPALWWVNGKGKELMW--NFRELSENSQQAANVLSGTCGLQRGDRVAVVLP
RVPEWWLVILGCIRA--GLIFM--PGTIQMKST-D--ILYRLQMSKAKAIVAGDEVIQEV
DTVASECPSLRIKLLVSE-KSWDGWLDFKKLLNE-ASTTHHCVET---------------
------------------GSQEASAIYFTSGTSGLPK-MAEHSHSSLSLKAKM--DAG--
----WTGLQA---SDIMWTISD------------------------TGWILNILGSLMEP
WALGACTF-------------------------------VHLLPKFDPLVILKT----LS
SYPIKNMMSAPI---VYRMLLQ---QDLS-------------SYK----FPHLQNC----
----LAGGESLLPETLEN--------WRAQTGLN---IREFYGQTET-GLT---CMVSKT
MKIKPGYMGTA--APRYDVQ------------IIDDKGNVLPPGTEGDIGI-RVKPIRPI
GIFSGYV-------------------DNPEKTAANIRGDFWLL--GDRGIKDEDGYFQFM
GRADDIINS-----------------------------SG-----Y-RIGP-L

PF13193 // ENSGT00760000119178_4_Domain_1 (894, 1026)

EVENALM
EHPAVAETAVISSPDPV-RGE--------------------------------VVKAFVV
LL-----------TKELQQHVKSV--------T--IEFVL-NL--PK------T------
--VTGKI--------QR-TKL---RDKEWQMSGKARAQ----------------------
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---------RKFHGN--NRLLTSQIISHYESI-NQG--KK-ELPEYFNFASDVLDEWARL
EKVGKKP-ANPAFWWVNEEGEEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 376)

SFEELGSLSRKAANVLSEACGLQRGDRVLAVLP
RVPEWWLLNVACMRA--GIVLI--PGTSQLTAK-D--ISYRLQASKAKCIVTNDTLAPAV
ESVLPGSQFLKSKLIVG-QGSRNGWRNFKELL----------------------------
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------------------------------------------MHWGRQL----QALCILW
RSQMS---NHTIRIH--TRQLASLQW---------G--HQ-EVPAKFNFATDVIDHWAGM
EKAGKRP-PGPALWWVNGNGDEVMW--N

PF00501 // ENSGT00760000119178_4_Domain_0 (269, 753)

FSQLSELSQQTANVFAGPCGLQRGDRVTVVLP
RVPEWWLVILGCMRA--GLVFM--PGTIQMKAK-D--ILYRLQVSKAKAIVAGDEVAEIV
DTVAPECPSLKTKLLVSE-KKRDGWLDFKTLLWK-ASTTHCFVET---------------
------------------GSQEAAAIYFTSGTSGLPK-MAEHSHSSLGIKAKM--DAG--
---KWTDLQA---SDIIWPISD------------------------TAWIVNILGSLLEP
WTSGACTF-------------------------------IHLLPKFDPVIILKV----LS
SYPINYMVGAPI---VYRMLLL---QDLS-------------SYK----FPHLKCC----
----FSGGETLLPDTLEK--------WKAQTGLD---ILEFYGQTET-------------
--------------------------------VIDDKGNVLPPGTEGDVGI-RVKPIRPI
GIFSGYV-------------------DNLEKTEANIRGDFWVL--GDRAIKDQEGYFRFM
GRTDDIINS-----------------------------SG-----Y-RIGP-SEVENALM
EHPAVVETAVVSSPDPI-RGE--------------------------------VVKAFVV
LAPHFLSRDPDELTKELQQHVKLVTAPYKYPRK--IEFVL-DL--PK------T------
--NTGKI--------QR-SKL---RDKEWKKSEQVGV-----------------------
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----------------------PLTLADFEAI-TLC--EK-PVPKKFNFAGDVLDQWSQK
EKTGERP-ANPALWWVNGKGDEVKW--

PF00501 // ENSGT00760000119178_4_Domain_0 (268, 910)

SFGELGSLSRKAANVLTKSCGLERGDRVAVILP
RVPEWWLVNVACMRT--GLVFI--PGTTLLTAK-D--ILYRLQASKAKCVVASEEVIPAV
ESIVSECPHLKTKLQVSP-RSRQGWLSLQELLQA-ASEEHSCVET---------------
------------------ASQEPMAIYFTSGTTGSPK-MALHSQSSLGIGYTI----SGR
---YWLDLKS---SDIIWNMSD------------------------TGWLKAAIGSLFAP
WLYGACIF-------------------------------AHHMIQFDADAFLDT----LS
TYPITTLCCAPT---VYRMLVQ---KDLK-------------RYK----FKKLHHC----
----MAGGEPLNPEVGEQ--------WKTQTGLE---LYESYGQTES-GVI---CANRRG
QKIKPGSMGKG--LPPHDVQ------------IIDENGDTLPPGKEGEIAI-RLTPTRPF
YLFSNYL-------------------DNPEKTAATMRGNFYLT--GDRGRMDSDGYFWFV
GRADDVIIT-----------------------------SG-----Y-RIGP-FEVENALM
EHPAVVETAVVSSPDPV-RGE--------------------------------VVKAFVV
LSASFKSSNPEKLIPELQAHVKESTAPYKYPRK--VEFVE-QL--PK------T------
--VTGKI--------KR-NVL---RDREWGRI----------------------------
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