Query Results 

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1909)

LVLLESQVVMSGLIAPETGENLSLEEGLARN-INTQMYQQL-ELQ

ENSGT00760000119163_1_Linker_7_8 (1909, 1945)

DALSLISR-HTE
GKG---PLPVVEAIENRTISERIG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKILEAHLATGGFSLSSSENCINLEEAFRQGLVTPQ
LYSVLESYLRSSKNLIDPNTAEKISLVDLMQRCIIHKESELKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CAIL
IRQLQTGGIIDTATGRRLTINEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITE
ALEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX---XX---XX-----XX-XXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXXXXXIETLT--PRDRSQ-IGPP---EVLGIEHQRLDTREELQE--AT
NVKSTEA-FFDGPTLGPHEFQVSSQNKEDPDQKNSTEAKGTQNIIETKGSY--------L
ESPGKDLFLVEQKVRNPDVNTLQ-VINKVKSEVQKQLLGTNKEDPTEVSTRKN-----VS
SGLP--VP-REETEGLCLAVDKDSFPIVIPAQEWQAV--RKTSVTCQKEQA--DILETEH
MSGENERTL---RKPQGKKSQFEVE-KTLDLEPELKSENEMNIQSLDKKKGVNKMPL---
----DRDD--HKQSQKGENIAGGGFRMMLEKRDEEDNGNETSPSRS----HPSELLEETT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2685)

LNILSAQLLDGGIVHEQTGQKLLLNEAVAQGIVPSHTAVKLMGK

ENSGT00760000119163_1_Linker_13_14 (2685, 2718)

FKMFRGFFDSQTHESL
TAEEVIGEGLMDEKLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2762)

RNVFMSDKAISGILDPRTHTLWSVKDAVAVGLLDKQTATKILE
G

ENSGT00760000119163_1_Linker_14_15 (2762, 2763)

Q

PF00681 // ENSGT00760000119163_1_Domain_15 (2763, 2800)

VVTGGIVDVKRGKKISVTLASNLGLVESADQTELLRLEKASKGRVSEKTVRERLISLQ
METTGIMDPDTKAPLTVVHAIDRGLLERKEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

IQLLTKQVVDGGIIHHVSGMRLSVNNAFK
HGLIDEDLSRKLKKV

ENSGT00760000119163_1_Linker_17_19 (2896, 2929)

ENLNHHQFFHPATKEIVSLPEAIKLDLITSDLK

PF00681 // ENSGT00760000119163_1_Domain_19 (2929, 2972)

REIQEIQSLTGS
FVDLISGQRLTVAEAKKEGLIT----NKTVP

ENSGT00760000119163_1_Linker_19_20 (2972, 3042)

SSGMMHGIVDPENYRIVPYSELVKKCKID
IESGQRYLEVIPFSDIRDGISGKVLTLREATQLGKVDFGPT

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3091)

LRVLEAQANTAGIINTTTG
KRLTLASALEQKLVDENMIRIIAS-----HQVSNGGIIDIFNDQRVNLEEAIERRLISPE
LAAMIQGDSSELTDHR-AQIEEPDG-TEVFKLKDEFLPKEMLITGNETAEMSY--DIEET
ERLF-QIESGSAEETAKLRLPDGE-------QAKNTRKTSLKESQYKDEGKRRASPD---
VKESVSIMIYGNLQGKSL--DQISLEHPH--SEVCDFKVKELVQDNVGNSKN----EEQE
KVVTQGEIVSHVKQS-VSGLDSKEIRENQREMIS-EVQE-SHYETS------SKLLLEQA
PQESMNI--KVKSKREKRETILEESVETCKPAVLSEEELNQETDIKDGLDSSVKSQPMEI
TIPETGKEA-DREPGFSITCKAKDSSS-QMMSKGISVRNHDALTFFNSRQA----NEGEI
N-----------NLSICLSLKTEENLCQEITDGAQT-DLSSSVTSRL-EDLHYQESVGEA
QDAETALSFK-ANVSFQGATMQETEYYQD-SCVTFKPKKTT--DLIFA---S-NE-CKEK
S-FQGSAKDLKL------------------------KD-NTVCRVDPKAVNYLKFSDGKD
LSHQDSKSDHELCGVSKSN-I-ATTQEITGEEFLEMANSA-VTDSEA--RSLEGRVTQGG
PRVLMSLFPEKLF--QNVS----QKEITGQQDAI-PSPTIPAISAEKT-TPLISWPTKMD
EK--------------TPE------EELR---------ES------PGGEQTVPGEKENG
GI-NLEPF---KPTKNVYN--------RRLCLEHDEKLVXXXXXXXXXXXXXXXXXXX--
--XXXXXXXXXXXXXXXVLDRELKDLSMLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSVNSVSDIWNSRLLNLQNVV-DAKKTEIL

PF00435 // ENSGT00760000119163_1_Domain_22 (3995, 4109)

NQQVQLEGRLEDLKAWIGNTSLNLSS
KHYSNE--T-DADSLNHCLQQYKDLKHPMADRKSQLDALAFDIQFFISEHARDLSPQQNR
QMLRLLNELQRSFQELAEKTAAQMDVLQSRLEQLEQAAQVK-TLQKQQNTCYQKLEDLCN
WVGQTERTLVGHH-ALST-QDLSTLKDQSD--LNLQDDIQNHATSFASVIKDIEGFLEEN
QTKLSPQELTALRQKLHQAKEQYEALQGQTRVAQKELEEAVTSALQQETEKTKAAKELAE
NRSKIDSLLEWVTSLG----------S--SGGQLETSLPRMEQLSGPG--LEKRALDTTD
GH-MGVSQAPEKLDEQCEKIKAHHQELLSQQQTFILVTQSAQAFLDQHSHSLTPEERQKL
QEKLGELKEQYATSLAQSEAELKRVQTLQ

PF00435 // ENSGT00760000119163_1_Domain_24 (4410, 4530)

DELQKFLQDHGEFENWLERSEKELENMHGGD
SS-PEALRSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFQKGSEPS---ATG
NLLKEKLRNATKRYTALHSKCARLGSHLNMLLGQYQQFQSSVDSLQAWMRTCEAKVEKLL
SDTIASDPGILQQQLATT-K--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXSILSRFQSLSCSLAERSALLQTAIAHSQSVQESLESLLQSIREVEKNLGEKQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFIETADSST-AVLLQGKLAEVSQR
FRQLCPQQQEKE-SLKKLL-QAEMFEHLSEKLQQFMKNKTRMLASGNQPDQDIARFFQQI
QELNLEMQDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLKKDFTELQKTVKEREED
ASSCQ

PF00435 // ENSGT00760000119163_1_Domain_27 (4866, 5022)

EQ-------LDEFRKLVTTFQKWLKETEGSIPPTETFRSTEELEKEIEHM-----
-KG-----LLDDWASKGTLVEEINCKGTSLENLIVEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDVSDVNLKYEKLGGVLRERQESL

ENSGT00760000119163_1_Linker_27_28 (5022, 5026)

QVVL

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

SRMQEVRKEASSVLQ
WLESKEEFLKAMDASSSPTKTETVRAQAESNKALLAELEQNSPKIQKVKDALAGLLTTYP
NSQEAENWRKMQEDLNLRWEKVTEVTMARQRQLEESASHLA-LQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQ--LREFEARRQQHDRLMEAAPGILTGPGDASLSTRQVH
QELQSITQKWVELIDQLNSRSTHFDRAIALSTEYQELLHDLSEKVKAIGQRLSGQSAINT
LPDAVKQQL-DTSEIRSDLEQVDNEIKEAHTLCEELSLLFDEHYLQDDLNKRLETVALPL
LGLEHL------ATDRMNRLQAAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVDLKSHWEELS
KKTADRQSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

ECL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVEDLVPWIDDCKAKMLDLRVTLDPVQLESNLLRSKAM
LSEVEKRRSLLEVLNSAADILINSSETDEDDIRDEKAGINQNMDTITEELQARTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEIAQQEFLEVRQRVNSGCMMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVGLFLNKIQVLKLDIEVSEVECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGRARQEQLELTL

PF00435 // ENSGT00760000119163_1_Domain_34 (5800, 5908)

GRVEDFYRKLKVLNDMTTAAE
EGEALQWVVGTEVDVISQQLADFKMFQKEQVDPLQMKLHQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINVRWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5911)

EAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEDLIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDML-AEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6022)

DIL

PF00435 // ENSGT00760000119163_1_Domain_36 (6022, 6128)

ILAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIVRHKALKEEIETHAADVHQAVKIGQSLSSLTCSAEQGVLSEKLDSLQVRYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLTLNEE
IVNRKKNVDQAIKNGQALLKQTTGDEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQAR

PF00435 // ENSGT00760000119163_1_Domain_38 (6240, 6346)

Q
LATKFQSTYEELTGWLREVEEELAAGGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTVGQRVDEID

ENSGT00760000119163_1_Linker_38_39 (6346, 6349)

AAI

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

QRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAVLQEKTESLIQQYEAISLLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELNPWIEETRS
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVGE
KYQKAEDMYAQIKEEVRQRALALDEAVSQSAQITE-------FHDKIEPMLETLENLSTR
LHMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXTIKEETDGLHEELEFIRI

PF00435 // ENSGT00760000119163_1_Domain_43 (6754, 6797)

LGADLIFACGETEKPEVKKSIDEMNHA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_43_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLIHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGSELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

SALQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMESQLSASKPIGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSIALLEQKWHVVSSKMEDRKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

SLATEF
QNSLQDFINWLTLAEQSLNIASPPSLILSTVLSQMEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCVTTIKHWITIIRAR
FEEX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX
XXXXXXXXXMFMEEMTRKQPDVDRVTKTYKRKNVEPTHAPFVEKSRSGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7783)

RVMDFFRRIDKDQDGKITR-

ENSGT00760000119163_1_Linker_53_54 (7783, 7799)

EFIDGILASKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEXXXXXXXXXXXXXXXX
XXXXXXXXXFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------IPSSGSKLKRPTPAFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSTAGGQGSSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

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----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 443)

QISDIYISGESGDMSA

PF00307 // ENSGT00760000119163_1_Domain_2 (443, 543)

KEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISAMEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLEFVPPST-------LTTTHLKAEPLTKATHS--------------SSTSWFRKPMTQA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSPNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVFRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEM-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLESFLRNL
HDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRNP
DHALKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GECHQVMKNLQA----HYEDFLQDSRDSVLFSVADRLRVEEEVEACKARFQHLVKSIENE
DKEETVAKMYISELKNIRLRLEECEQKVVKRIQSLASSRTDKDARQDNALRIAEQERTQE
DLQQLKSDLDAVSTKCNSFLHQSPSGSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTI
DVIVRSIQDAELLVKGYEIKLSQEEAVPADLSALESHRSTLRHWLSDVKEKNSVFSVLDE
EIAKGKVVAEQLSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLETRQTELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKSTSS-QTKES
TDIEKAILEQQVLAEELTTKREQVSEAIKTSQIFLAKHGHKLSEKEKEQISEQLNSLNKT
YHDLCDGSATQLQQLQSQLAQQTEQKDSRA--VAGVIDLGT--VEIFPVFRAMQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LMLLESQVIMSGLIAPETSENLSLEEGLARNLINPQMYQHLQEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

QDALSLISR-LTE
SKG---PLSVVEAIEKRIISERIG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1987)

LKILEAHLATGGFRLSASGNCINLEEAFHQGLISSW
LHSVLESHLRSSKNLIDPNTAEKISLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSSR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2098)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMAC

ENSGT00760000119163_1_Linker_10_11 (2098, 2103)

AIF
IR

PF00681 // ENSGT00760000119163_1_Domain_11 (2103, 2139)

QLQTGGIIDTVTGQRLTIDEAVSNGLVAAKIALVIL

ENSGT00760000119163_1_Linker_11_12 (2139, 2146)

ESLWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2177)

GLLWPDSGEILPVTD
ALEQGIVSSELAHKIL

ENSGT00760000119163_1_Linker_12_13 (2177, 2641)

SNRQHIKALFLPANTEIWSWEKAIENGILDKDLANNLKLIRIPD
VMPHVQLADSLERNKSSIHPEAASR---LCSEGQS-----QH-IASHSEK-LLFQLMTHS
YVNVQNGQRLLLLDKELMETLT--CG---D-YHPP---EVLGIGHQRLQTPKKFQE--SG
NVKITGT-LNDGLTVRPPEFQFSSQNKEYPDQEDCIEAKGEGTIAETEGSS--------I
ENPEKDLFVREQKEKNPNVGTLK-VINKVKSESQRQLLGTKKEDQTERSTRED-----IS
RVRLLTVP-PGEAEGVRLVVDKDLSSVETSVKECQPF--TSTSFTCQKEQA--NTLETEY
IPGETGRPL---IKTQNKMSQFQAE-KTLGIKSEVKSESAMNIHSLDKKEVLNKTVL---
----ANDG--HKQSQEGQNMV-AGSMTTLEKTD-EGDGGETSLSRS----HPSELLEEAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2682)

LNVLSAQLLDGGILHEQTGQKLLLNEAIIQGIVPSHTAVKL

ENSGT00760000119163_1_Linker_13_14 (2682, 2719)

MGKLNMFRGFFDSQTCESL
TTEEVIGEGLMDEKLL-H

PF00681 // ENSGT00760000119163_1_Domain_14 (2719, 2760)

NVLKADKAISGVLDPRTQTLCSVKDAVAVGLIDKETATKILEGQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQIELINLEKASKGRDVEKTVRERLISLQMETTGFIDPDSKAPLTVVQSIDRGLLEREEAIHLLTKQVVDGGVIHHVSGMRLSVDNAFKHGLIGEDLAKQLKKVENLNFHQFSHPETKETIFLPQAIKLGLITPDLKREIQEIQAFSGNFVDLISGQRLTLAEARKEGLLT----NKAILSSGMMNGIVDPENYRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDRVLTLSQAVQLGKLDFAPTLNILEAQANSGGIIDSATGKRLTLGSALEQKLLDENMFRIIAS-----HQVLSGGIIDVFNDQRVTMKEAIKKGLISPELATMIQIDTLEFSDQR-AQTEK-EGGIEVCELKNEFLGKEMFIACNQTVEIHC--DKRQSERLL-QIESKSAQEKVQVRISDRE-------QAEKSKEVSLKELGYKDQDEWKTSAN---ATDFVSTTIPPHLKGKSS--GQVSITHPH--SEVCDFRLKEVTKNTVEKDIN----EEQEKVVTQTENVPHTKQS-ASHLDSGEIRENQGKMIS-EEQH-T-----------GKLLSEQVMQQRVNT--RVKRENEKEEMNVEESAKTCRS---AEEKLNRETAMRDE----HDSTPMEMTLSEKGKEA-DREMELSTVGKIEDSST-QMFPKGIPVKNQSTLMFLSSKEA----SEGVVK-----------NLSFSLTLKQEEDLSQEITYGTQS-EPFPSVTRKP-EGLYYQESVKNAQVTDTSQVSK-TDKSFQGTVRQETKYYQD-SHVISKTKETK--DLVFS---S-NE-YKEMS-YQEVPFDPTRA-------------------LNL-KE-IEVSGVDTKEVNYLKFSDRKDLHHQDSKSDRELA----------RMQEISSEKFLEMANPAGVTGLEV--GSVEDIVAQRGPAVSVSLPPEQQ---------------------------DAITSEEKT-VSLTLFSTVKTDE--------------RTQQERLAESPGN---------------------DVPGGKRNEDV--NPEPL---RATQNVFN--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL----ELNLAELQDLLCQAKVLDRELKDLSSLISQELECVDQIIISQPQEVPAQLLMALEKDAKNLQKSLSSVSGTWSSRLLQFQNVV-EVKKTKVLNEHLQLEGKLQDLRAWVGNTTLMLKSKGCSDE--M-DVDSLNHYLRQHEDLKQPMAERKSQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDLWEQTSTQMDALQGHLRQMEQEALVK-TLQKQQNTCHKKLEDLCNWVGQTERALVGHQ-GRVTQQDLATLQKNQSDLKDLRDNIQNHVASFATVVKDIEGFLEENQTKLSPHELTALQEKLHQAKEQYEALQERTRAAQKELEEAVTSALQHETEKSKAAKELEENKSKIDALLDWVTSVG----------S--SGGQVETSFPRMEQLSTAS--LDKGALDTTDGY-MGVNQAPEKLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLDQHGHNLTPEERQMLQGKLGELKEQYATCLTQSEAELKRVQTLQDELQKFLQDHREFESWLERSEKELENMHKGSSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-VISFKEGQEPS---TTGNLVKDKLKDASERYTALHSKCTRLGSHLNMLLAQYQQFQSSADSLQAWMQTCEASVQKLLSDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVAHDLMEIEGEPAPDHKHVQE-TTDSILSHFQSLSCSLAERSALLQKAIARSQSVQESLESLLQSLREVEQNLEGEQVASLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQRFEQLCLRQQEKESSLKKLLPQAEMFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQIQELNLEMEDQQENLNTLEHMVTELSSCGFALDLSQHQDRVQNLRKDFKDLQKTVKEREKDASSCQEQ-------LDEFRKLIRTFQKWLKEIEGSIPPTETFMSAKELEKQIEHL------KS-----LLDDWTSKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDLSDVNLKYEKLGGVLQERQESLQSVFSRMEEVQREASSMLHWLESKEEVLKSMDVSSSPTKTETVKAQAESNKAFLAELEQNSPKIQEVKEALAGLLVTYPNSQEAENWKKMQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFETRRQQHEQLNEAAQGILTGPGDVSSSTSQVQKELQSINQKWVELTDRLNSRSNQIDQAIVKSTQYQELLQDLSEKVKTVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKCHWEELGKKTADRQSRLKDCMQKAQKYHWHVQDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSETDEDDIRDEKARINQNMDAITEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAETSQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLRLDIEASEAECRQMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYKKLKVLNEATTAAEEAEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQGLEHDMEEINARWNTLNKKVAQRTAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHK-------------------------------------------------------------------------------------------------------------ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVSSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGTCGEEQKAVLQEKTESLIQQYEAISLLNSDRYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYIQIKEEVRQRALALDEAVSQSA---QV---CVYFHDKIEPMLETLENLSSRLCMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKTRAEEREMKFLDVLELAEKFWYDMAALLTTIRDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLIHTEELLDAQRPVSGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTLQ-QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPDDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRIDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEQIPQNIDRVKALIAEHQMFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRRG-----KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------------------IPSTSSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2758, 2791)

ILE
GQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQIELINLEKASKGRDVEKTVRERLISLQ
METTGFIDPDSKAPLTVVQSIDRGLLEREEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2895)

HLLTKQVVDGGVIHHVSGMRLSVDNAFK
HGLIGEDLAKQLKKVENLNFHQFSHPETKETIFLPQAIKLGLITPDLKREIQEIQAFSGN
FVDLISGQRLTLAEARKEGLLT----NKAILSSGMMNGIVDPENYRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDRVLTLSQAVQLGKLDFAPT

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3091)

LNILEAQANSGGIIDSATG
KRLTLGSALEQKLLDENMFRIIAS-----HQVLSGGIIDVFNDQRVTMKEAIKKGLISPE
LATMIQIDTLEFSDQR-AQTEK-EGGIEVCELKNEFLGKEMFIACNQTVEIHC--DKRQS
ERLL-QIESKSAQEKVQVRISDRE-------QAEKSKEVSLKELGYKDQDEWKTSAN---
ATDFVSTTIPPHLKGKSS--GQVSITHPH--SEVCDFRLKEVTKNTVEKDIN----EEQE
KVVTQTENVPHTKQS-ASHLDSGEIRENQGKMIS-EEQH-T-----------GKLLSEQV
MQQRVNT--RVKRENEKEEMNVEESAKTCRS---AEEKLNRETAMRDE----HDSTPMEM
TLSEKGKEA-DREMELSTVGKIEDSST-QMFPKGIPVKNQSTLMFLSSKEA----SEGVV
K-----------NLSFSLTLKQEEDLSQEITYGTQS-EPFPSVTRKP-EGLYYQESVKNA
QVTDTSQVSK-TDKSFQGTVRQETKYYQD-SHVISKTKETK--DLVFS---S-NE-YKEM
S-YQEVPFDPTRA-------------------LNL-KE-IEVSGVDTKEVNYLKFSDRKD
LHHQDSKSDRELA----------RMQEISSEKFLEMANPAGVTGLEV--GSVEDIVAQRG
PAVSVSLPPEQQ---------------------------DAITSEEKT-VSLTLFSTVKT
DE--------------RTQQERLAESPGN---------------------DVPGGKRNED
V--NPEPL---RATQNVFN--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNLAELQDLLCQAKVLDRELKDLSSLISQELECVDQIIISQPQEVPAQLLMALEKDA
KNLQKSLSSVSGTWSSRLLQFQNVV-EVKKTKVLNEHLQLEGKLQDLRAWVGNTTLMLKS
KGCSDE--M-DVDSLNHYLRQHEDLKQPMAERKSQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQDLWEQTSTQMDALQGHLRQMEQEALVK-TLQKQQNTCHKKLEDLCN
WVGQTERALVGHQ-GRVTQQDLATLQKNQSDLKDLRDNIQNHVASFATVVKDIEGFLEEN
QTKLSPHELTALQEKLHQAKEQYEALQERTRAAQKELEEAVTSALQHETEKSKAAKELEE
NKSKIDALLDWVTSVG----------S--SGGQVETSFPRMEQLSTAS--LDKGALDTTD
GY-MGVNQAPEKLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLDQHGHNLTPEERQML
QGKLGELKEQYATCLTQSEAELKRVQTLQDELQKFLQDHREFESWLERSEKELENMHKGS
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-VISFKEGQEPS---TTG
NLVKDKLKDASERYTALHSKCTRLGSHLNMLLA

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQAWMQTCEASVQKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVAHDLMEIEGEPAPDHKHVQ
E-TTDSILSHFQSLSCSLAERSALLQKAIARSQSVQESLESLLQSLREVEQNLEGEQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLRQQEKESSLKKLLPQAEMFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQI
QELNLEMEDQQENLNTLEHMVTELSSCGFALDLSQHQDRVQNLRKDFKDLQKTVKEREKD
ASSCQEQ-------LDEFRKLIRTFQKWLKEIEGSIPPTETFMSAKELEKQIEHL-----
-KS-----LLDDWTSKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDLSDVNLKYEKLGGVLQERQESLQSVFS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQREASSMLH
WLESKEEVLKSMDVSSSPTKTETVKAQAESNKAFLAELEQNSPKIQEVKEALAGLLVTYP
NSQEAENWKKMQEELNSRWERATEVTVARQRQLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5143)

ESASHLAC

PF00435 // ENSGT00760000119163_1_Domain_29 (5143, 5244)

FQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFETRRQQHEQLNEAAQGILTGPGDVSSSTSQVQ
KELQSINQKWVELTDRLNSRSNQIDQAIVKSTQYQELLQDLSEKVKTVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKCHWEELG
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYHWHVQDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LNEVEKRRSLLEILNSAADILINSSETDEDDIRDEKARINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAETSQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLRLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYKKLKVLNEATTAAE
EAEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRTAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6226)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHK------------------------------------------------------
-------------------------------------------------------ALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVSSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAVLQEKTESLIQQYEAISLLNSDRYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYIQIKEEVRQRALALDEAVSQSA---QV---CVYFHDKIEPMLETLENLSSR
LCMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKTRAEEREMKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIRDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6802)

DAMQA

PF00435 // ENSGT00760000119163_1_Domain_44 (6802, 6910)

AVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLIHTEELLDAQRPVSGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRIDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEQIPQNIDR
VKALIAEHQMFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRRG-----KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7944)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------IPSTSSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQME
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPCT-------LTTTHLKAEPLTKATHS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GECHQIMKNLQA----HSEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENE
DKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDARQDNALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPALRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDE
EIAKAKAVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-ETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKA
YHDLCDGSANQLQQLQSQLAHQTEQKECRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1904)

VLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQ

ENSGT00760000119163_1_Linker_7_8 (1904, 1947)

LRELQDALALISR-LTE
SRG---PLSVVEAIEKRIISERVGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1985)

ILEAHLATGGFSLSPSENCINLEEAFHQGLISAW
LHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2102)

IL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD
VMPHMQLADS---AEQNINPGAAVL---PCSKSHP-----KA-IASQSEN-LLFQLMTHS
YINVQNGQRLLLLDKELMETLT--SRDEYQ-TSPP---KMVEIGHQRQKTPEGLQE--SA
NVKISGT-FSDGWTVRLPEFQFSSQNKEHPDREDCTTEKGKKTTVETEDSS--------V
ENPEQDLFVEQ-KERNPNIDALK-VINKVKLEVQRQLIGTKREDQTAVSIREN-----AS
RGHLLTIP-PAEAEGVPLVVDKDVFSVETPKKEHQ--PLRNTSFTCQNEQA--HTLETEY
IHDETGGSH---IKPQSKKSQVQVK-KTLGIKLELKSETDGNVHPLDKKEMLKKTFL---
----AKDD--HKESQEAQNIA-GGSMMMSEKTDEEDSGREIFLSFS----HPLELLEEAT
LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIAPSHTAVKLMEKLNMFQGFFDSQTCESL
TTEEVINEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENVSLPKAIKLDLITPDLKREIQEVQAFTGNFVDLISGQRLTLAEAEKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHR-AQIEKQAG-IEVCALQNEFLRKDMLIACNQTAEMSC--NKVEESERLFQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFGCKDQRKPRMSSD---AKEFISIINPHNLKGKSL--GQVSLTHPY--SEVCDFKLKEVARNNMGNDTN----EEQEKAVTKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQVLQQPMNA--GVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEA-DTEMGFSITFKIEESSS-QVVPQGISVKHLDALTLFSSKQA----NEGKVN-----------NLSLCLTLKPEENLSREIACGAQS-EPFPCMTPRP-EGLHYQESDGKAQVTGPSQISK-TDKSFQGTTRQETNYHQD-SWVTSKTKETK--HQISS---S-NE-CKEKS-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSE-I--ATQELTGEKFLEMANPN-VAGLEA--GSIEDIVTQRGSRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVLETSEERT-VSLTVC-SAVKTE--------------KTPQEKLRESPGS---------EQ------TPFMTAPEGKGNGGV--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPL----ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLESRLQDLRAWVGNKNLILNSKGSNSE--I-DVDSLNHCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-GRTTQRDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSGAS--LEKGALDTTDGY-MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHREFESWLERSEKELENMHKGGSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSFKEGKEPS---EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSTSAKELEKQIEHL------KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHILKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNTEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQST---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTL-QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDTQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
RQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQ
METTGLIDPDSKAPLTVVQSIDRGLLEREEAV

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLTKQVVDGGIIHHISGMRLSVDNAFR
HGLIGEDLAEKLKRVENLNIHQIFNPETKENVSLPKAIKLDLITPDLKREIQEVQAFTGN
FVDLISGQRLTLAEAEKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANTGGIIDTATG
KRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLVEAIEKRLISPE
LANMIQIDSSEFSDHR-AQIEKQAG-IEVCALQNEFLRKDMLIACNQTAEMSC--NKVEE
SERLFQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFGCKDQRKPRMSSD---
AKEFISIINPHNLKGKSL--GQVSLTHPY--SEVCDFKLKEVARNNMGNDTN----EEQE
KAVTKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQV
LQQPMNA--GVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREM
TSSEKGKEA-DTEMGFSITFKIEESSS-QVVPQGISVKHLDALTLFSSKQA----NEGKV
N-----------NLSLCLTLKPEENLSREIACGAQS-EPFPCMTPRP-EGLHYQESDGKA
QVTGPSQISK-TDKSFQGTTRQETNYHQD-SWVTSKTKETK--HQISS---S-NE-CKEK
S-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVRYLEFSDRKD
LHHQGSKSDDKLCGTLKSE-I--ATQELTGEKFLEMANPN-VAGLEA--GSIEDIVTQRG
SRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVLETSEERT-VSLTVC-SAVK
TE--------------KTPQEKLRESPGS---------EQ------TPFMTAPEGKGNGG
V--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPL--
--ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLESRLQDLRAWVGNKNLILNS
KGSNSE--I-DVDSLNHCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTQRDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSGAS--LEKGALDTTD
GY-MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML
QQKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQACEANVEKLL
SDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSTSAKELEKQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVHKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHILKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6127)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNTEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQST---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

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-------------MRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPVRDS
HCPDLRLPSPEIIPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQEE
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTIHLKAEPLTKATHS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFRT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHMKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIHSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLIQTWNLEKLRSSAP
GECQQIMKNLQG----HFEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENE
DKEETVAKMYISELKNIRLRLEEYEQRVIKRIQSLASSRTDKDAREDNALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTI
DVIVRSIQDAELLVKGYEIKLSQEEAVPADLSALEAHRSTLRHWLSDVKDKNSVFSVLDE
EIAKAKAVVEQMSRLTSERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELEGIQEVLG
DYRTCHGTLIKWIEATTTQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQAHVEKVKELLGWVSSLARNTQGKATSS-QIKES
TDIEKAILEQQVLAEELTTKREQVSEAIKTSQIFLAKHGHKLSEKEKEQISDQLNALNKT
YHDLCDGSANQLQQLQSQLAHQTEQKDCRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGR

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1904)

VLLESQVIMSGLIAPETSENLSLKEGLARNLINPQMYQQ

ENSGT00760000119163_1_Linker_7_8 (1904, 1947)

LRELQDALSLISR-LTE
SQG---PLSVVEAIEKRIISERIGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1985)

ILEAHLATGGFSLSPSENCVNLEEAFHQGLISAW
LHSVLESHLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTI

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2097)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMA

ENSGT00760000119163_1_Linker_10_11 (2097, 2103)

CATL
IR

PF00681 // ENSGT00760000119163_1_Domain_11 (2103, 2138)

QLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGMVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKLICIPD
VMPNMQLADS---AERNINPGAAVL---PCDKSQS-----KG-ISSQSEN-LLLQLMTHS
YINVQNGQRLLLLDEELMETLT--SRDEYQ-TSLP---KVDEIGHQRQNTPEGLRE--SA
NVKISGT-FGDGWTVRLPEFQFSSQIKEYPSQEYCTTEEGKKTTVETEGSS--------V
ENPELDLFVGEQKERNTNVDALK-VINKVKLEVQRQLIGAKREDQTAVSVREN-----VS
RGPLLTVP-PEEAEGVLLVVDKDLFSVETPKKEHQHQPLRNTSFIYQNEQA--HSLETEY
IHDETGGSH---IKPQSKKPQVQVK-KTLGIKLELKSETDVSVHPLDKKKMLKKTFS---
----ARDD--HKQSLEAQNIA-GGSVMMLEKTDEEDSGRETSLSHS----HPSELLEEAT
LNV

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIFHEQTGQKLLLNEAVAQGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2721)

LMEKLNMFRGFFDSQTCESL
TTEEVIDEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGILDPRTHTLYSVKDAVTLGLLDKETATRILERQVATGGIIDLKRGKKVSVTLASTLGLVDIGDQPELINLEKASKGRDAEKTVRERLLSLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAIRLLSKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAKNLKKVENLKIHQFFNPGTKETVSLPKAIKSDLITPDLKSEIQDIQAFTGNFVDLISGQRLTLEEAEKEGLLA----YEEVLSPGMMHGIIDPENCRIVPYSELVKKCKIDIESGQRYLEIIPFSGIKDGVSNKLLTLSEAIQLGKVDFASTLKVLEAQANTGGIIDAATGKRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLEEATEKRFISPELANMLQRDTSEFSDHR-AQIEKQEG-IEACALQNEFLRKDLLIACNQTAEMSC--NKGEESERLLQIENHSAQEKVKVRVSDGE-------QAKESREISLQEFGCKDQHKPRMSPD---VKEFISIINPHNLEGKSL--GRVSLTHPY--SEVGDFKLEEVSRNNMGKDTN----EEQEKAVTQIEIISHMKKS-TSCLDSEEIRENQGEVIL-EVAE-SYCETS------GKLPSEQVLQQPVNT--RVKN-REKREVTVEESIKTYKSAVFSEEKLYQETAIRDEHDSHIKSQPREMTSSEKQKEA-DTEMGFSVTFSTEDSSA-QVAPKGISVKHQDAVTLFSSKQA----GEGKVN-----------NISVCLTLKPEENLSEEIACGAQS-EPFPSMTPRP-EGLHYQESDGKAQVTDASQISK-TDKSFQGTTRQETTYHQD-SYATSKTKETK--HLISS---S-NE-CKEKS-SQEVSFDSVRG-------------------LKL-EE-ITVSRADSKEVSYLEFSDRKGLHYQGSKSNDKLCGTLKSE-T--ATQEITGEKFLERANPK-VTGPEA--GSVEDIVTQRGSRVLASFLPEKLL--KDGS----QKENSGQQNAT-ISPTVPETSDEKT-VSLTVC-STMKTE--------------KIPQEKLRESAGN---------EQ------TPFITAHGEKGNGDV--NPEPF---RAIQNVFT--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL----ELNLAELQNLLCQAKLLDRELKDLTTLISQELECVNQIIISRPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV-EVEKTKVLNQHTQLEGRLQDLRAWVGNTNLILNSKGSNSE--T-DVDSLNCCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSLQQNRQMLRLLNELQKSFQDILEQTAAQADALQGHLQQMEQEVLVK-TLQKQRNTCHQKLEDLCSWVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQDDIQNHVTSFATVVKDIEGFMEENQTKLSPYELTALREKLHQAKEQYEALQEQTRVAQKELEEAVTSVLQQETEKSKAAKELAENKKKIDALLEWVTSVG----------S--SDGQLLTNLPGMEQFSGAS--LEKGALDTTDGY-MGVNQAPEKLDKQCEKMKARHRELLSQQQNFILATQSAQAFLDQHGYNLTPEEQQMLQEKLGELKEQYSTSLTQSEAELKRMQTLQDELQKFLQDHREFESWLERSEKELENMHKGGSS-PKALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFKEGKEPS---EIGNLVRDKLQDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQTCEANVEKLLSDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQE-TTDSIFSHFQSLSYSLAERSALLQKAIAQSQSVQESLETLLQSIGEVEQNLEGNQVASLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADGTT-AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQIQELSLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEYL------KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHESQESLQAVLNKMEEVQKEANSVLQWLESKEKVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNYRWERATELTVARQRQLEESASHLAYFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILMGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKTVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDQEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQTKNCPISAKLEQLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWVEDCKAKMSELRVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAVGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEVECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEEFYRKLKGLNDATTGAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAEVADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT-SAEQGVLSEKIDSLQARYREIQDRCCRKAALLDQALANARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEGELAANGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGTCGEEQKAVLQEKTESLIEQYEAISLLNSDRYARLERAQVLVNQFWETYEELSPWIEETRTLIAQLPPPAIDHEQLRHQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVEEKYQNAENMYAQIKEEVRQRALALDEAVSQS---AQ-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISENKSATVELEKLQPSFEALKHRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTLQ-QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLSEDTQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQTLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLSSPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
RQVATGGIIDLKRGKKVSVTLASTLGLVDIGDQPELINLEKASKGRDAEKTVRERLLSLQ
METTGLIDPDSKAPLTVVQSIDRGLLEREEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLSKQVVDGGIIHHISGMRLSVDNAFR
HGLIGEDLAKNLKKVENLKIHQFFNPGTKETVSLPKAIKSDLITPDLKSEIQDIQAFTGN
FVDLISGQRLTLEEAEKEGLLA----YEEVLSPGMMHGIIDPENCRIVPYSELVKKCKID
IESGQRYLEIIPFSGIKDGVSNKLLTLSEAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANTGGIIDAATG
KRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLEEATEKRFISPE
LANMLQRDTSEFSDHR-AQIEKQEG-IEACALQNEFLRKDLLIACNQTAEMSC--NKGEE
SERLLQIENHSAQEKVKVRVSDGE-------QAKESREISLQEFGCKDQHKPRMSPD---
VKEFISIINPHNLEGKSL--GRVSLTHPY--SEVGDFKLEEVSRNNMGKDTN----EEQE
KAVTQIEIISHMKKS-TSCLDSEEIRENQGEVIL-EVAE-SYCETS------GKLPSEQV
LQQPVNT--RVKN-REKREVTVEESIKTYKSAVFSEEKLYQETAIRDEHDSHIKSQPREM
TSSEKQKEA-DTEMGFSVTFSTEDSSA-QVAPKGISVKHQDAVTLFSSKQA----GEGKV
N-----------NISVCLTLKPEENLSEEIACGAQS-EPFPSMTPRP-EGLHYQESDGKA
QVTDASQISK-TDKSFQGTTRQETTYHQD-SYATSKTKETK--HLISS---S-NE-CKEK
S-SQEVSFDSVRG-------------------LKL-EE-ITVSRADSKEVSYLEFSDRKG
LHYQGSKSNDKLCGTLKSE-T--ATQEITGEKFLERANPK-VTGPEA--GSVEDIVTQRG
SRVLASFLPEKLL--KDGS----QKENSGQQNAT-ISPTVPETSDEKT-VSLTVC-STMK
TE--------------KIPQEKLRESAGN---------EQ------TPFITAHGEKGNGD
V--NPEPF---RAIQNVFT--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNLAELQNLLCQAKLLDRELKDLTTLISQELECVNQIIISRPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EVEKTKVLNQHTQLEGRLQDLRAWVGNTNLILNS
KGSNSE--T-DVDSLNCCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSLQQNR
QMLRLLNELQKSFQDILEQTAAQADALQGHLQQMEQEVLVK-TLQKQRNTCHQKLEDLCS
WVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQDDIQNHVTSFATVVKDIEGFMEEN
QTKLSPYELTALREKLHQAKEQYEALQEQTRVAQKELEEAVTSVLQQETEKSKAAKELAE
NKKKIDALLEWVTSVG----------S--SDGQLLTNLPGMEQFSGAS--LEKGALDTTD
GY-MGVNQAPEKLDKQCEKMKARHRELLSQQQNFILATQSAQAFLDQHGYNLTPEEQQML
QEKLGELKEQYSTSLTQSEAELKRMQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4516)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PKALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFKEGKEPS---EIG
NLVRDKLQDATERYT

ENSGT00760000119163_1_Linker_24_25 (4516, 4534)

ALHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVEKLL
SDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQ
E-TTDSIFSHFQSLSYSLAERSALLQKAIAQSQSVQESLETLLQSIGEVEQNLEGNQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADGTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQI
QELSLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEYL-----
-KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHESQESLQAVLN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

KMEEVQKEANSVLQ
WLESKEKVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIQEELNYRWERATELTVARQRQLEESASHLAYFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILMGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKTVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDQEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQTKNCPISAKLEQ
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWVEDCKAKMSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAVGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEVECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGR

PF00435 // ENSGT00760000119163_1_Domain_34 (5802, 5908)

VEEFYRKLKGLNDATTGAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAEVADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6127)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLT-SAEQGVLSEKIDSLQARYREIQDRCC
RKAALLDQALANARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEGELAANGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAVLQEKTESLIEQYEAISLLNSDRYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRT
LIAQLPPPAIDHEQLRHQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVEE
KYQNAENMYAQIKEEVRQRALALDEAVSQS---AQ-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISENKSATVELEKLQPSFEALKHRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLS
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQTLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLSSPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

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-------------------------FQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQG
LEHDMEEINTRWNTLNKKVAQRVAQLQEALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELISNQKPP
SAEYKVVKAQIQEQK--LLQRLLDDRKATVEMIQAEGDRIAQAAEPADRDKIVGQLESLA
RRWEGLLGRAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6126)

AKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQ
QISRHKALEEEIESHATNVSQALGVGQSLSSLSCAAEQRLLAEKLEALQSRYGEVRERCG
RKAALLDQALANARLFGEEEVEVLNWLAEVEDKLGSVSIKDYKRDVLQKQHADQLALNEE
IVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSKALRTLEQARQ
LATKFQSTHEELTGWMSKVEDELASSGAQSPAGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTIKQRVEEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGT
CGEEQKALLQEKTESLVQQYEAVSQLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6564)

NQFWETYEELNPWIEETQA
LISQLPPPAIDHEQLKQQQD-DMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQE
KYSRAEALYAKIKEEVCQRALALDEAFSQSTQVAL-------FHDKIEPMLETLEGLSSR
LRLPPLIPAEVDKIRECISENKNSTVELEKLQPSFEALKRRGEELIARSQGADKDLAAKV
IQDKLDQMVFFWEDIKARTEEREMKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

EAMQSA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNAVIKLCNMSPVGTDLSTV
KEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EAALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRNRLEKLNSCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYSQLKAKED
VYSQLLAKGRLMLLNRDDSGSSSKTEQSVALLEQKWCLVSTKMEERKAKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7138)

EALALA

PF00435 // ENSGT00760000119163_1_Domain_47 (7138, 7240)

TDF
QNSLQDFINWLTLAEQSLNIAPPPSLILAAVLAQIDEHKVFANEVNAHRDRIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRAL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKALLS
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIDNSRDDTTWVKVQLQE
LSNRWDTVCKLSVSKQTRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRTAVHMLLEWLSEAEQSLRFRGAL
PDDAEALQALIDAHKEFMKKVEEKRVDVNAAVGMGEVILGACHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLESALSELVANAELLEELLAWIQWAE-TTLIQRDQDPMPQNIDQ
VKALISEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGPFIDKSRSN-R---KCLGQAA
PPSMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7944)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCASMPSSPATPASGAKV-------------------------
------------TPSAGSK-LR--PTFHSSRTSLAGDTCNSSSPASTGAKAT--------
------------------------------------RADPKKAASRPTSRAGSRTGSRAS
SRRGSDASDFDLLETQSACSDTSESSTAGGQSSRR----AAKPSKIPTMSKKTPAATPKT
PGPKR

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-------------MRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQVQCFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTPLQFSRCYDKPWLVNSKAGTHVRDS
HCPDLQLLSPEVIPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

MGNSLGCVKEPKESIAVPEKAPISPKKRVRFKRKWRGKKTPILEAPHKEKPLEVTGVIEE
TKTLTKFTASLPKEHGVGGAEHPPSDILLLGDSA-PNSGVGDQGMIVQVKERFQAEIQTA
HLLLEAESSVVGGVWGSLEKGMTVIAHLLDNPAERNCEKSVSQLVEFPRTASCSSRAVLL
PLQGETAVEQGSTLLGFQSGTLPGTDYPSDTGDQDQLSEGWSVGGRTKN-----------
V------------------------LSAPPTGSWIAKYSFASSIQ--SVDPIHIEDTHVG
EVSLRGPILPASQSDLSVGGITVSILPSSSGYGS--------------------------
-------------DGLPLHGIRPEDTE-----------PEKTSTPFSEEDGTLSLEASHT
D----GGISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATDVDARWQEYQSRVDSLLPWIRQHTLLMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIKELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDEKYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLNKTTHS---------------STSWFRKPMTRA
ELVSISSSEDEGSLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFRT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNGKEEEELACDWSDSNPNISAKKTYFSELTMELEGKQ-DVFRSLQDTAER-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENAAYFQFFSDARDLESFLRNL
QDSIKRKYTCDHSTSLSRLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHLLKSTISVKAICDYRQIEVREEKLHSCVG-----PTACHC----CS------------
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-----

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---------------------------------------------------ALTCF----
LHIPEPFFSVS-------FADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGIGAMEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAVHLESGQTVQCESDV
IMYIQECESLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELAPSST-------LTTTHLKADSLTKGTH---------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLEAQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHS-SYVETLGKLEMQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPSISAKRNYFSELMMELEEKQ-DVFQSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLETFLKNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKAIIQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
APNKDAVEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLQKDLDLVQTWNLEKLRSLAP
GECHQVMKNLQA----HYEDFLQDSHDSALFSVSDRLRLEEEVETCKAHFQHLMKSMENE
DKEETVAKIYISELKNIRLRLEECEQRLIKQIQCPASSRTDRDARQEIALRIAEQEHTQE
DLQQLRSELDAVCTKCNSFLHQSPSGSSVPTLRSELNLLVEKMDHVYGLSVVYLNKLKTI
DVIVRSIQDAELLVKGYEIKLSQEEAVPADLSALESHRSTLRHWLSDVKDKNSVFSVLDE
EIAKAKVVVEQLSHLTPERSLDLERYQEKGSQLQERWHRVI-AQLETRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKIDLF-HTKES
TDIEKAIWEQQVSERPVA----------------LCRWNNVLSEKEKEQISEQLNALNKT
YHDLCDGSANQLQQLQSQLAQQTEQKGCRA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1905)

VLLESQVIMSGLIAPETSETLSLEEGLLRNLINSQMYQQLLELQDALFLVIR-HTE
SKS---PLSVVEAIEKRIISERVGLKVLEAHLASGGFSLSPSEDCINLEEAFHQGLISTW
LHSLIESHLRSSKNLIDPNTAEKISLLDLMQRCIIHKESGLRLLPVKQLAGGMVSLKSGR
KVNIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVEETVRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2102)

IL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIINTVTGHRMTIDEAVSNDLVAAKIALVILESLWSFMGLLWPDSGEILPITD
ALEQGIVSTELAHNILSNRQHIKALFLPATTEIWSWKKAIENGILDEDLTNNLKSICIPD
VMPNMQLTDSSVRNDLSITSGAAAL---PCRKGQA-----EA-TGNHSEK-LLFHLMTHS
YINVQNGQRLLLLDQELMETLT--SRDEYH-TGLP---VVFGIGHERLHTHEELQE--SV
NRNITET-FNDRLTVRPCELQFSSQNKEGINQEDCSETEAKGKKTDTGTGYS-------V
ENPEKHLLVGEQNVVNANVDALK-VINKVKSELQRQLSGTKKEIQTEVSTREN-----DT
RRLLLVVP-PEEG----PLV----------KEEWQAP--RKTYLTSQKEKA--KTFKVEY
TPSEIERPL---VNSQSKKSQLQVE-KSLGLKSELKSGNDTNIHSLDEEKVSHKKLL---
----PRGD--HKQSQEGQNIADGS--MILEKIGTEDNDSETSLLCS----HPSELLEDTT
LNI

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LCAQLLDGGIVHEQTGQKLLLNEAVAQGIVPSHIAVKLMEKMNMFRGFFDSQTCESL
TTEEVIDEGLMGEKLL-HKVLMTDKAISGVLDPRTHTLCSVKDAVGIGLLDKETAS

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
GQVVTGGIVDLKRGKRVSVTLASNLGLVDFTDQTELITLEKASKGKDTEKPVRERLISLQ
METIGVVDPDSKAPLTVVQSIDRGLLEKAEVIH

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2892)

LLTKQVVDGGIIHHASGMRLSVDNACK
HGLIGEDLAKELKKIEKVNLHQFFHPEIKETLPLSEAIKLDLVAPNFEKEIQDIQSFSEN
FVDLISGQRLTLAEANKERLIT----NKAILPSGMMHGVVDPENYRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDKVLPLSEAIQLGKVDFVSTLKVLEAQANTGGIIDTATG
KKLTLASALEHKLVDENMARIIAS-----H

PF00681 // ENSGT00760000119163_1_Domain_21 (3091, 3125)

QVLNGGIVDIYNDKRVTLKEAVEKGFISPE
LATVIQTDTVKSA-----VIEKQDG-IEVCELKDEFLRKEKLIACNKTAEMSC--DKRES
ERFF-A------QEKFKGKISSGE-------QAKKSREIS--ELEGKDHKKGRVSPA---
TAGSVSIIIPSNLNRKSS--SQLSMPHPY--SEVSDFKLK-VDRNNMEKNTN----VEQE
KVMTQIEIITHMKQC-TSGLDAEEVTENQEEMIS-EVQE-SNWKPP------GRFLSDQ-
---PVNT--REKSKREKREVIVEKSVNTCKPAVFSEKKLTQKTSGRDEHDSNIKSRSVEM
LKEEKGKEA-DRDMELSVICKIEDSSF-PMTPKGISVGNQDALTFFTST--------QKV
K-----------NVSLSLTFKTKENLSQKIAGRAQS-ESFSSVTPRP-EELHHQQLAGKP
QITDTSRISK-AHKIVQETTRQEISFYRG-SCVTSETKEAK--DLIFP---S-KE-CKEK
S-DQEVPFDPTSA-------------------LKL-EK-ITVARVDPKEDSCLESSDRKD
LHYQDSKDNPELCEILKSK-I-VTTQETNEEKFLEVGNPV-VTGPET--GSLEGRVTQKS
PRVLVSLLPEKLL--KGVS----QKESTGHQDAI-ITLTVPEISEEMA-GPLTSCSTVTL
DG--------------KTPQ-----EKLN---------EQ------TLFIAAPEGKGKRS
GGVNPEPL---RATQNVFN--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--GLNLAELQDLVCQAKVLDRELQDLSTSVSQELDSVNAIIVSQPQEVPTQLLKALEKDA
KNLQKSLSSVSNTWSTRLLHLQNAV-EVKKTTVLNQHTQLEGKLQDLRAWVGNSSLILNN
KECDNE--T-DVDSLTHSLQQYKDLKQPMAERKSQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQDLVDRTAAQTDALQGCLQQMQQEAQVN-TLQKQQNTCHQKLEDLCS
WVGQAERALVSHQ-GRASQQDLSALQKNQSDLKDLQEDIQNHATSFTTVVKDIEVFLEEN
QTKLSPQELTALQEKLHQAKEQCEALQEQTRVAQKELEEAVSSALQQETEKSKAAKELAE
NKSKIDSLLNWVTSMG----------S--SGGQPQTSLPGMEPLSGAS--LMKGAVDTTD
GH-MGVNHAPENLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLEQHGHNLTPEDQQKL
QEKLGDLKEQYAASLAQSETDLKRVQTLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4520)

ELQKFLEDHREFESWLEQSEKELENMHKGG
IG-PEALPSLLNQQGSFSEDVISHKG-DLRFVTISGQKVLDA-ENSSEESKEPS---TTR
DLVKEKLKDATERYTALHS

ENSGT00760000119163_1_Linker_24_25 (4520, 4534)

KCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQSWIQTCEGNVEKLL
SDTVASDPGVLQQQFTMT-K--KLQEELAEHQVPIEKLQKVARDFMEIEGEPALDPKHIQ
E-TTDSILSHFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEGEQVTS
LSSGVVQEALANNMKLKQDIARQKSSLEATCEMVTQFMETADSTT-AAVLQGKLVEVSQR
FEQLRLQQQEKESTLKKLLPQAEMFEQLSDKLQQFMENKSRMLASGNQPDQDIAHFSQQI
QELTLEMEDQQENLDTLEHLVTALGSCGFALDLSQHQNKVQNLKKDFTELQKTVQERGKD
ASSCQEQ-------LNEFRKLIRTFQKWLRETEGNIPPSETFMSAKELEKQIEHL-----
-KG-----LLDDWTSKGTLVEEINHKGTSLENLITEITAPDSPAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNVKYEKLGGVLQDRQESRQAILS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQEEASSVLQ
WLESKEEVLKAMDATLSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGFLMTYP
NSQEAEHWKKMQEELNSRWERATEVTVARQKQLEESASHLAGFQVAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSPSTSQVQ
KELQSINQKWVDLTNKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAISA
QPEAVKQQLEETSEIRSDLEQLDSEIKEAQTLCDALSVLIGEQYLKDELKKRLETVSLPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRAWLDEKQSQQAKNCPISAKLEQ
IQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQMVELKSHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5578)

KAQKYQWHVEDLVPWIEDCKAKLSELQVTLDPVQLESGLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNMDAITLELQAKAGLLEEM
SQRLKEFQESLKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASELLHQAEVAQQEFLEVKQRVNSGCMAMENKLEGIGQFHCRV
REMFSHLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKFDIEASEAECQQMLE
EEGTLDLLGLKRELEALNKQCSKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKALNDATTAAE
EGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALDPLLSWLADTEDLIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGDRIAQSAELADREKITGQLASLE
SRWIELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6025)

DILILA

PF00435 // ENSGT00760000119163_1_Domain_36 (6025, 6230)

KQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKAL----------------------------------------------------
---------------------------------------------------------NEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYVDITVASSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQILQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSGANEQYKLISDTVGQRVDEIDAAIQRSQQYEQAADS
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAVLQEKTESLIQQYEAVSLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEDLSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVED
KYQQAENMYAQIKEEVRQRAVALDEATSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIRDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6805)

DAMQAAVH

PF00435 // ENSGT00760000119163_1_Domain_44 (6805, 6910)

YQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAYRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMGWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTKMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMVLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKLKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLFQMEEHKVFANEVNAHRDHIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLG
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDAVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNVEPTHAPFIEKSRGGSR---KPLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKI-------------------------
------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

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-------------------------------------------------LNPEEGEMVEE
KYQKAENLYAQIKEEVRQRALALDEAVSQSA--

PF00435 // ENSGT00760000119163_1_Domain_41 (6574, 6684)

-Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECVSDNKSATVELEKLQPSFEALKRRGEELIARSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIRDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEVYGK
LD---KEFR---------------------------------------------------
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-----

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVIMSGLIAPETSEKLSLEEGLARNLINPQIYQQLQEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

EDALSLISR-LTE
NKG---PLSVVEAIEKKIINEKVG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKILEAHLATGSFSLPPDENCINLEEAFHQGLISAW
LYSVLESHLRSSKNLIDPNTAEKIGLLDLMRRCIVYQESGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRVLEAQLFAGGIVDPRTGHRLTVGEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CALL
IRQLQTGGIIDTVTGRRLTVDEAVSNDLIAAKIALVILES

ENSGT00760000119163_1_Linker_11_12 (2141, 2146)

LWSLM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2180)

GLLWPESGEILPITD
AREQGIV-FELAHKILSAR

ENSGT00760000119163_1_Linker_12_13 (2180, 2641)

QHIKALYLPATTEIWFWKKAVENGMLDKDLANNLKSICIPD
VMPHMQLADSLERSKLNTNPGAAGV---LCSKGQT-----EG-IASHNEK-LLFHLMTHS
YINVRDGQRLLLLDNELIEALT--ARGD-Q-ASPP---EVFGSGHQRLDAPEKLQE--SV
NVKITET-FCDGLTVRPHEFQFSSQNKEDPDQANCTEAKGKKTIVETE------------
ENTKRDLFVGQQKVGNPNVDTLK-VIDKVKSEFKRQLLDTKKEDQIEVSTREN-----VN
KGFLLMVP-PEEAEDVTLVEDKDPFPVESPKEEWQTL--RKTSFMCQKEQA--DTLETEY
TLGETGRPL---IKPQSRKSQFQIE-KALVLESELKSEKDKNIHL-GRKKALNKTCL---
----GRDD--HKQSPEGHSMAGG-GMMLLEKTDKEANGSETSLSCS----HPSELLEEAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2686)

LNILSTQLLEGGIFHEQTGQKLLLNEAIARGV-PSHTAVKL-RKL

ENSGT00760000119163_1_Linker_13_14 (2686, 2718)

NMFRGFFDSQTCESL
KTEEVIDEGLMDEKLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2762)

HNVLMADKAISGVLDPRTHTLCSVKEAVAIGLLDTQTATRILE
G

ENSGT00760000119163_1_Linker_14_15 (2762, 2763)

Q

PF00681 // ENSGT00760000119163_1_Domain_15 (2763, 2800)

VVTGGIVDLKRGKKVSVTLASNLGLVDSADQTELINLEKASKGRDAEKAVRERLISLQ
LETTGIMDPDSKAPLTVVQSIDRGLLERDEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

MQLLTKQVVDGGIIHHISGMRLSVDSAFK
HGIIDEDLAEQLKKV

ENSGT00760000119163_1_Linker_17_19 (2896, 2929)

ESLSLHQFSHPETKETISLSEAIKLDLVTPDLK

PF00681 // ENSGT00760000119163_1_Domain_19 (2929, 2974)

REIQEIQALTGS
FIDLISGQRLTLAEAEKEGLLT----NKEMLSSGMMNGIIDPENYRIVPYAELVKKCKID
IESGQRYLEVIPFSDIKDGASDKVLTLSQAIQLGKVDFAATLKVLEAQANAGGIIDTATG
KRLTLASALEQKLVDESMVRIIAS-----RQ

PF00681 // ENSGT00760000119163_1_Domain_21 (3092, 3129)

VLDGGIIDIFNDQRVTLKEAIEKRLISPE
LATIIQVD

ENSGT00760000119163_1_Linker_21_22 (3129, 3995)

TFESCDHQ-AQSEK-QGRSEVCELKKEFLRKEMLIACSQTAEMSC--GKGES
EKLF-QIENQSAQKKVKVRVSNGE-------QAKKSREISLKELECKGQVRRS-SRG---
AKESFSVIISS---------DGXSVTHPH--SEICDLNPKEVAYNTMEKNTN----EEQE
NIVAQTEIISQMKQF-ISGLDSKEIRENQGEIIS-EVQE-SNCETL------GKLPSQQV
MQKPMKT--REKGKRGKREMTVEESVKTRKPAVLSEEKLNQETAIRDDHDSNIESQPVEI
TISEKGKET-DGELGFSVVGEAEDSSS-QMIPKGISVRNQDALTFFNSNQV----SEGDV
K-----------NLSLCLTLKPEENLSQEVTVGTQS-EILSSLTPQP-EGLCYQEPVGEA
QVADTSPVFT-TEKSFRGTTRQETNYHQD-SCVTFKIRETK--DLTFS---S-NE-SKEK
S-YQEVPFDSTSA-------------------VKL-EE-I---RVGSKDVTYLEFADRKD
LRPQDNKSDGERCGILESK-I-VLE------------IPI-VTGAEA--GSFEGIVTQGV
PRVSVSLLPEKLS--KDVS----RKESTGQEDAT-ISP-SPETREEEM-VPLISYPTMKM
DE--------------KTPQEKLRKSSEPGS-------EQ------NPFMTAPGG---TS
V--NPEPF---RAAKNVFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--EXXXXXXXXXXXXXXVVDRELKDLSTVVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWGSRLLHLQNAA-EVKKTRVL

PF00435 // ENSGT00760000119163_1_Domain_22 (3995, 4106)

NQYEQLEGKLQDLRAWVGNTHLILNN
KEHVDE--TDAIDSLSHHLQQCEDLKQPMAERKSQLDALAFDIQFFISEHAQDLPPQQNR
QMLRLLHELQRSFQDHVDRTTAQVD

ENSGT00760000119163_1_Linker_22_23 (4106, 4126)

ALQGRLQQMEQAARLK-TLQ

PF00435 // ENSGT00760000119163_1_Domain_23 (4126, 4239)

KQQNTCHQKLEDLCN
WVGQAERALAGHQ-GRATQQDLSALQKNQSDLKDLQGDIQNHATSFASVVKDTEGFLEES
QAKLSPHELTALREKLHQAKEQYEALQERTKLAQKELE

ENSGT00760000119163_1_Linker_23_24 (4239, 4410)

EVVTSALQQETEKSKAAKELEE
NRSKIDALLDWLTSHP----------VGSLGGQ-------MEQVSGGN--LEKGALDTTD
GH-MGVNQAPETLDKQCEKLKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML
QEKLGELKEQYVTSLAQSEAELKQVQTLR

PF00435 // ENSGT00760000119163_1_Domain_24 (4410, 4530)

DELQKFLQDHREFENWLERSEKELENMHKRD
SS-PEALPALLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSLEEGKEPS---ATG
TLVKDKLKDATERYSALHSKCTRLGAHLN

ENSGT00760000119163_1_Linker_24_25 (4530, 4533)

LLL

PF00435 // ENSGT00760000119163_1_Domain_25 (4533, 4647)

GQYQKFQSSAESLQAWMKACEANVEKLL
SETVASDPGVLQQQLVTT-K--QLQEELAEHQVPVEKLQKVAHDFMEIEGEPAPDHRHVQ
E-TTDSILSHFQSLSSSLAERSALLQ

ENSGT00760000119163_1_Linker_25_26 (4647, 4650)

KAI

PF00435 // ENSGT00760000119163_1_Domain_26 (4650, 4757)

AQSQSVQESLDSLLQSIGEVENNLEEEKVAP
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFTETADSNS-AAVLQGKLAEVSQR
FEQLRLQQQEKESSLK

ENSGT00760000119163_1_Linker_26_27 (4757, 4866)

KLLPQAEMFEHLSDKLQRFMENKSRLLASGNQPDQDIAHFFQQI
QXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEED
ASSCQ

PF00435 // ENSGT00760000119163_1_Domain_27 (4866, 5023)

QQ-------LDEFRKLVRTCQKWLKETEGSIPPTETFMSTKELEKQIEHL-----
-KG-----LLDDWTSKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGEVLRERRESLQ

ENSGT00760000119163_1_Linker_27_28 (5023, 5026)

AVL

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

SRMQEVQQEAGLVLQ
WLELKEEVLKGMEASSSPTKTETVRAQAESNKAFLAELEQNSPKVQNVKEALSGLLMTYP
NSQEAENWKKMQEELNSRWEMATEVTMARQRQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQXXXXXXXXXXXXXXXXXXXXXXXXTGPGDVSPSTSQVQ
KELQSINQKWIELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVRQRLSGQSAIST
QPEAVKQQLEETSEIRSDVEQLDHKIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------A-DRMNRLQAAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLDDKQSQQAKNRPISAKLER
LQSQLQDNEEFQKNLNQHSGSYEVIVAEGESLLLSVPPGEEKKTLQNQLFELKSHWEELS
KKTADRQSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVEDLVPWIEDCKVKMSDLRVTLDPVQLESNLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNMDSITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQTLEPQVDY
LRNFTRGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCMAMESKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQALKFDIEASEAECRQMLE
EEGTLDLLGLKRELEALSKQCGKLMERSKARQEQLELTL

PF00435 // ENSGT00760000119163_1_Domain_34 (5800, 5908)

GRVEDFYRKLKALNDMTTAAE
EGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5911)

EAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQAAERADREKITGQLESLE
TRWTGLLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIVRHKALEEEIESHATDVHQAVKIGQSLSSLTCSAEQGVLSEKLDSLQARFSEIQDRCC
RKAALLEQAL

PF00435 // ENSGT00760000119163_1_Domain_37 (6131, 6237)

SNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITLTSSKALRTLEQARQ
LAAKFQSTYEELTWWLRGVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTVGQRVDEIDAAI

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

QRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAILQEKTESLIQQYEAISLLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELSPWIEETRT
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVQE
KYQKAENTYAQIKEEVRQRALALD

ENSGT00760000119163_1_Linker_40_41 (6565, 6574)

EAISQSA--

PF00435 // ENSGT00760000119163_1_Domain_41 (6574, 6688)

-QI---TE-FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWRERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPMTELKHLWENLGE
KIAHRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

STLQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMETQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRLLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVCKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FRDTIHMLLEWLSEAEQTLRFRGAL
PDDTEALRSLIDTHKEFMKKVEEKRVDVNTAVAMGEVILVVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLE

ENSGT00760000119163_1_Linker_50_51 (7579, 7582)

AAL

PF00435 // ENSGT00760000119163_1_Domain_51 (7582, 7720)

SELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKIIEPAHAPFMEKSRGGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLN

ENSGT00760000119163_1_Linker_51_53 (7720, 7763)

DALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRITVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKI-------------------------
------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSA-AGQGSSRRGL--NKPSKIPTMSKT-TTASPRT
PGPKR

MGNLLGCVKEPKESIAVSKKAPISPKKRVRFKRKWRRKKIPIPKASHEEESLEGIGVIEE
TGTLTKLPVSLPKEDQVGGAEHPPSDILQPRGSA-PSSAIGDQGMIVQVKERFQAEIQTA
HLLLENESSVARGAWDSLEEGMTVIAHLLDNPADRNCEKSVSQLVEFPRTASCSSRAVLL
PLQGETAVERGSIPLEFQSSTSPGTDHPFDTRNQDQLSEDWSVGEGTNS-----------
V------------------------SSAPPAHSWIAKCSVASSLPKESGDPQSTELTQVG
RVLPTVPRMPVSQSDLSASGITLSVLPSSSGYGS--------------------------
-------------NGLHLHGIQPGDTE-----------PEKSSTPFSEEDATLSLEASHT
H----HGISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEKEKGRIKELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADATHLELGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTSLYRKGHFT
SLELVPPST-------LTTTHMKTEPLSKTTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVESQLEAQQHIHTSVEEL
GSSVKEARLYEVCSIQNPHS-KS----------CREEWEMSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDSNPNIPSKKNYFSELTVELEGKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLELFLRNL
QDSIKRKYTCDHTTSLSRLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHALKSTISLKAICDYRQIEVRSGLGIWAPE-----RR----------------------
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MGNSLGCFKEPKESIAIPEKAPISPKKRVRFKRRWRGKKIPTPEASHQEETSEGTEVIEE
TETLTKLTVSLQKEDGVGGVEHTPPDILLPGDSA-PNSQVVDQGMIVQVKERFQGEVQTA
HLLLENESSVAGGVWDSLEEGMTVIAHLLDNPAERNCEKSVSQLVEFPRTASCSSRAVLL
PLQGETAVEKGNIQLGFRSCALLRTDYPTDTGNQEQFSEGWSVEEGTKS-----------
V------------------------SGAPQTGSWIAECSVSSSLLDKPGGQRRTEPSHVG
LVPLQDSRLPTSQSDLSISGVTVSILPSSSGYGS--------------------------
-------------DGPHIHGIQPKDTE-----------PEKSSTSFSEEDGTLSLEASHT
PSWGLEEISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFA
SLELVPPST-------LTTTHLKAEPLTKAPYS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQVGVY----------------------------
------PKAYAGKMSQNFHT-SYAETLRKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSCLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHLLKSTISVKAICDYRQIEVRR-------------------------------------
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MGNSLGCVKEPKESIAVPEKAPISPKKRVRFKKKWKGKKISAPGASHKEEPLEGTGVTEE
TETRRKLTVSLQKENGVGGAEHHPSDISLPGDSA-QSSQVGDQGMIVQVKERFQGEIQTA
HLLLENDSSTAGEVWDSLEEGMTVIAHLLDNPAERNCERSVSQLVEFPRTASCSSRAVLL
PLQSKTAVERGSAQLGFQSSTLPGKDYPSNTRSQDQLSDSWSVREGAN------------
I------------------------LRAPPVGSQTAESSVPSSLLGQSAGPRYTESGQVG
QVPPQGLKLPASQSNLSISGMTVSILPSSSGYGS--------------------------
-------------DGLCLHGTQPKDTE-----------PEKSSISFTEEDGTLSLEVSHT
PSWGLEEISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQTNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVLRLQDELVTLRLECANLYRKGHFT
SLELVPPSN-------LTTTHLKTEPLTKTTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMTLERAEWGSDLPTVESQLEAQQHIHASVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTMELEKKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMRQLCLCVEQHLKENIAYFQFFNDARDLESFLKNL
QDSIKRKYSCDHNTSLSRLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKAIIQLKPRSP
DHVLDSTISVKAICDYRQIEVRSLFF----------------------------------
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------------------------------------------MPFLDSSYLPPTIFILTH
VLGVA--GVLYWKRHTRGRADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQEE
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKAPYS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFRT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHLLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLIQTWNLEKLRSSAP
GECHQIMKNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKAHFQHLMKSMENG
EINIDTGRAWWL---------------------------------MSVILALWEADHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEAVLADLSALEAHRSTLRHWFSDVKDKNSVFSVLDE
EIDKAKAVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-QTKES
TDIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNQA
YHDLCDGSANQLQQLQSQLAHQTEQKDCRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGLA

PF00681 // ENSGT00760000119163_1_Domain_7 (1866, 1904)

LLESQVIMSGLIAPETGENLSLEEGLARNLINPQMYQE

ENSGT00760000119163_1_Linker_7_8 (1904, 1947)

LRELQDALALISR-LTE
SRG---PLSVVEAIEKRIISERVGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1985)

ILEAHLATGGFSLSPSENCINLEEAFHQGLISAW
LHSVLESHLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2096)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2102)

ACGIL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGQRLTINEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD
VMPHMQLADS---AEQNINHGAAVL---PCSKSQP-----KA-IASKSEN-LLFQLMTHS
YINVQNGQRLLLLDKELMEILT--SRDKYQ-TSPP---EVVEIGHQRQKTPEGLQE--SA
NVKISGT-FSDGWTVRLPEFQLSSQNKEYPNQEDCTTEKGKKTTAETEDSS--------V
ENPEEDLFVEQ-KERNSNVDSLK-VINKVKLEVQRQLIDTKREDQTAVSIKEN-----AS
RGHLLTVP-PAEAEGVPLVVDNDLFSVETPKKEHQ--PLRNTSFTCQNEQA--HTLETEY
IHDETGGSH---IKPQSKKSEVQVK-KTLGVKLELKSETDVNIHPLDKKQMLKKTFL---
----AKDD--HKETQEAQNIA-GGSMMILEKTDEEDNGRETFLSYS----HPSELLEEAT
LNV

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2721)

LMEKLNMFQGFFDSQTCESL
TTEEVINEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGILDPRTHTLCSVKDAVTVGLLDKETATRILE
RQVVTGGITDLKRGKKVSVTLASTLGLVDIADQPELINLEKASKGRDAEKTVRERLISLQ
METTGLIDPDSKAPLTVVQSIDRGLLEREEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLTKQVLDGGIIHHISGMRLSVDNAFR
HGLIGEDLAKKLKRVENLNIHQIFNPETKETVSLPKAIKLDLITPDLKREIQEVQAFTGN
FVDLISSQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKID
IESGQKYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANTGGIIDTATG
KRLTLASALEEELVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLAEAIEKRLISPE
LANMIQIDTSEFSDHR-AQIEKQEG-IEVCALQNESLRKDMLIACNQTAEMSC--NKVEE
SERLLQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFSCKDQHKPRMSPD---
AKEFISIINPHNLKGESL--GQVSLTHTY--SEVCDFKLKEVARNNMGNDTN----EEQE
KAVTKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQV
LQQPMNA--GVKSKREKREVIVEESIRTCKSAFLSEEKLYQETAIRDEHDSHIKSQPREM
TSSEKGKEA-DTEKGFSVIFKTEDSSS-QVAPQGISVKHLDALTLFSSKQA----SEGKV
N-----------NLSLCLTLKPEENLSQEIACGAQS-EPFPSMTPRP-EGLHYQESDGKA
QVTGSSQISK-TDKSFQGTTRRETNYHQD-SCVTSKTKETK--HLISS---S-NE-CKEK
S-YQEVSFDPARG-------------------LKL-EV-ITVSRPDSKEVSYLEFSDRKD
LHHQGSKSDDKLCGTLKSE-I--ATQEITGEKFLEMANPN-VTGLQA--GSIEDIVTQRG
SRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVPETSEEKT-MSLTVC-STVK
TE--------------KTPQEKVRESPGI---------EQ------TPFMTALGGKGNGG
V--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTRQMQPL--
--ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EIEKIKVLNQHTQLEGRLQDLRAWVGNTILTLNS
KGSDSE--T-DVDSLNRCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQEILEQTAAQVDALQGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFAAVVKDIEGFMEEN
QTKLSPHELTALREKLHQAKEQYEALREQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSRAS--LEKGTLDTTD
GY-MGVNQAPEKLDKHCEKMKARHQELLSQQQHFILATQSAQAFLDQHGHNLTPEEQQML
QEKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSECTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVGKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQ
E-TTDSILSHFQSLSYSLAERSALLQKAIAQSQSVQESLESLSQSIGEVEQNLEGKQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTPLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGILHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLMTYP
NSQEAENWKKIEEELNSRWERATEVTVARQRQLEESAGHLASFQAAESQLRPWMMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSTQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDQEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LHSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGADASQLLHQAEVTQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAVGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLKSLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6128)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLKEVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQSMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAREE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHAVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQHRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPIPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLPSPEVISSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

MGNSLGCVKEPKESIAVSEKAPISPKKRVRFKRKWRGKKTPTLEASHKEEPLEGTGVIEE
TETLTKLTAGLPKERGVGGAEHPPSDILLPGDSA-PNSGMGNQGRIVQVKERFQAEVQTA
HLLLENESSVVGGVWDSLERGMTVTAHLLDNPAERNCEKSVSQLVEFPRTASCSSRAVLL
PLQGETAVGQGGTPLGFQSSTLPGTDYLSDAGDQDQLSEDWSVGGRTKK-----------
V------------------------LSAPPTGSWIAKCSVASSILKHSGDPICIEPTHVG
QVSYRGPIMPASQSDLSVSGITVSILPSSSGYGS--------------------------
-------------DGLHLHGIRPEGIE-----------PEKTTTPFSEEDGTLSLEASLT
D----RGISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIRQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEIPAKEREKGRIKELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELAPPST-------LTTTHLKAEPLNKTTHS--------------SSSSWFRKPMTRT
ELVSISSSEDEGSLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHA-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNGKEEEELACDWSDSNPNIAAKKTYFSVSVTQQ-----DVMLNSSSKRQR-----
TS---PQRHCCSVAYNAAVQSQLQWMKQLCLCVEQHVKENAAYFQFFSDARDLESFLRNL
QDSIKRKYTCDHSTSLSRLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEVRVIYIY---------EGACAC----KGQK----------
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-----

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-----------------------------------------ALSSTTENLNEIRC-----
----DSLLCVS-------FADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEKEKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELAPPST-------LTTTHLKAEPLTKATHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGSDLPSVELQLEAQQHIHASVEEL
GSSVKEARLYECGMC--------------YHLQMQRLAETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTVELEKKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMRQLCLCVEQHVKENTAYFQFFSDARDLESFLKNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKAIIQLKPRSP
DHMLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
APNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GEYHQVMKNLQT----HYEDFLQDSHDSALFSVADRLRIEEEVETCKAHFQHLMKSMENE
DKEETVAKIYISELKNIRLRLEECEQRLVKRIQSPASSRTDKDARQDTALRIAEQEHTQE
DLQQLKSELDAVSTKCNSFLHQSPSGSSVPTLRSELNLLVEKMDHICGLSAVYLNKLKTI
DIIVRNIQDAELLVKGYEIKLSQEETVPADLSALESHRSTLRHWLSDVKNKNSVFSVLDE
EIAKAKVVAEQLSRLTPERSLDLERYQEKGSQLQERWHRVI-AQLETRQSELESIQEVLG
EYRACHGTLIKWIENTTAQQETMKPGQAEDSRVLSEQLSQQTDLFAEIESNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKITSF-HTKES
TDIEKAIWEQQVLAEELATKKEQISEAIKTSQIFLAKHAHKLSEKEKEQISEQLSVLNKT
YHELCDGSANQLQQLQSQLAQQTEQKGCKA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1905)

VLLESQVVMSGLIAPETSEMLSLEDGLARNLINPQMYQQLLELQDALFLISR-HTE
SRG---PLSVLEAIEKRIINERIGLKVLETYLATGGFSLSPSENCVNLEETFHQGLISTW
LHSLVESHLRSSKNLIDPNTAEKVSLLDLMQRCIIHKESGLRLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVQEAVRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2102)

IL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGHRMTIDEAVSNDLIAAKIALVILESLWSFMGLLHPDSGEILPIID
ALEQGIVSTELAHDILSNRQHIKALFLPATTEVWSWKNAVENGILDEDLANNLKSICIPD
VMPNMQLADSADQSNLRITSQPAAL---PCSKGQT-----ED-IASHDEK-LLFQLMTHS
YVNVQNGQRVLLLDQELMETLT--SRDEYH-ASPP---EVFGIGHQRPYTHEELRE--SV
NRNIAET-FSDSLMSRPCERQFSSQNKEHPNQEDCSEAKNEKINTRVEYS-S-------I
ENPEKHQLVEQ----NVSNANLK-VIDKVKLELQRQLSGAKKEAQTEMSTKEN-----DT
KGLLLGVP-PEEG----LLVGKDLFSIETPEEELQTP--RKTSLTNQKEKR--KTFMVEH
TPCATERLL---LNSQSKKSQLQIE-KSVSLKSEVLSENDMNIPSLNEEKMLSKMLL---
----ARDD--HKQSQKGQNIADGN--MMSEKIKTEGNGGETSMLCS----HPSEVLEDST
LNI

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LCAQLLNGGIIHEETGQKLLLNEAVAGGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2726)

LMGKLSMFRGFFDPQTCESL
TTEEVIDEGLMDEKLL-HKVLMTDK

PF00681 // ENSGT00760000119163_1_Domain_14 (2726, 2759)

AISGVLDPRTHTLCSINDAVRIGLLDKETASQILEGQVVTGGIIDLKRGKRVSVTLASNLGLVDITDQTELINLEKAFKGKDTEKPIRERLIRLQMETTGFMDPDSKVPLTIVESIDRGLLEKEEAVHLLTKQVVNGGIVHHTSGMRLTVDNAYKHGLIGEDLAKQLKKVENVNLHQFFHPETKEALSLPEAIKLNLVAPDVKKEIQEIQTFNENFVDLISGQRLTVAEANKKGLLT----NKAISSSGMMHGVIDPENYKIVPYSELVKKCKIDIESGQRYLEVIPFSDIRDGVSDKVLSLSEAIQLGKVDFVSALKVLEAQANTGGIIDTATGKKLTLASALEQKLLDENMARIIAS-----HQVLSGGIVDIFNDERVTLKEAVQKGLISPELATVIHTDTVKS---------EQDD-IEVCESEDEFLRKEKLIVYSQIAKMSC--DKGESEKLF-A------QEKFEGKVSNGK-------QTRKKREIS--EFKGKDCEKGRASPD---TIGSVSDIIPSSINMKSA--SPVSVPHSH--SEVANFKLS--GAGNMGKNTN----VEQEKVMPQIETLTHMKKS-SLDLDAEDATEN-QEVIS-EVQE-FNRKPP------GKFLNEQ----PVNT--REKSKRE-KETTVEKSVNSCKSAAISEKKLTQKTADRDEHKSNKKKQSMEMVKGEKEKEA-DRDKELSVICKTEDFSS-QMTPKGISVKNQDALTFFTSTPM----SEEERK-----------NVSLCLTFKTGENLSKKIDVGAQS-EPFSSVTPTS-EESDFQQLVGKPQITDTSQMSK-TDNIVQRATRQETNFYQG-SCVTLETKETK--DLIFP--------LQEKS-DQELPFDSKSA-------------------LKL-GK-FTVSRIDPNEVSYLESSDRKDLHYQDSKDDLELSEILKSK-I-AVTQETNGEKFQEV-NPV-VTGPET--GSLEGIVTQKVPRDLVSLVPEKLF--KDVS----EKVSAVQQGVI-VALSALETSEEMA-LPLTK------DG--------------KTPQ-----KELS---------EQ------SPSMAGPEGKGSRSGDGNPQPL---RATQNVFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL----ELNLAELQDLVCQAKVIDRELQALSTLVSQELECVNQIIVSQPQEVPTQLLKALEKDAKNLQKSLSSVSNTWSTRLLHLQNAV-EVKKTTVLNQHTQLESELQDLRAWVGDTSVILNNKECNSE--A-DVISLSHSLQQYKDLKQPMAERKSQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQKSFQDLVDWTAAQTDALQGRLQQVQKEAQVK-TLQQQQNTCHQKLEDLCSWVGQAERALESHQ-GRASHQELSALQKNQSDLKDLQEDIQNHTTAFTTVVKDIEVFLEENQTKLSPQELTALQEKLHQAKEQYEALQEQTRVAQKELEEAVSSALQQETEKSKAAKELAENESKIDALLNWVTSVG----------S--SSGHQQTTLPGMKQLSGAS--PMQGTLDTTDGH-MGVNHAPENLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLEQHGHNLTPEEQQNLQEKLGDLKEQYAASLARSEAELKQVQTLRDELQKFLQDHREFESWLERSEKELENMRMGTIG-PEALPSLLKQQGGFSEDVISHKG-DLRFVTISGQKVLDA-ENSSEESKEPS---TTSDLVKERLKDATERYTALHSKCTQLGCHLNMLLGQHQQFQSSADSLQSWMQACDANVKKLLSDTVASDPGVLQQQLAMT-K--KLQEELAEHQVPVEKLQKAAHDFMEIEGEPAVDPKHVQE-TTDFILSHFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEVEQVTSLSSGVIQEALANNMKWKQDIARQRSSLEATREMVTQFMETADSTT-AAVLQGKLAEVSQRFEQLLLQQQEKESTLKKLLPQAEMFEQLSDKLQQFMESKSRMLASGNQPDQDIAHFSQHIQELTLEMEDQQENLDTLEHLVTALGSCGFSLNLSQHQNKIQNLKKDFTKLQKTVQEREKDASSCQEQ-------LDEFRKLIRTFQKWLRETEGNIPPLETFISAKELEKQIEHL------KD-----LLDDWTSKGTLVEEINHKGTSLENLITEITAPDSPAKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNVKYEKLGGVLRDRQDSLQAILSRMEEVQKEASAVLQWLESKEEVLKAMDATLSPTKTETVTAQAESNKAFLAELEQNSPKIQKVKEALAGLLMTYPNSQEAENWKKMQEELNSRWERATEVTVARQKQLEESASHLAGFQSAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLREFEARKQQHEQLNEAAQGILTGPGDVSPSTSQIQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDNEIKEAQTLCNELSVLIGEQYLKDELKKRLETVTLPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERIQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQMVELKSHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKLSELQVTLDPVQLESGLLRAKAMLSEVEKRRSLLEILNGAADILINSSETDEDGIRDEKAGINQNMDAITLELQAKTGLLEEMSQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLLQAEVIQQEFLEVKQRVTSGCMTMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVWLFLNKIQAVKFDIEASEAECQQMLEEEGTLDLLGLKRELEALNKQCSKLTERGKARQEQLELTLGRVEDFYRKLKALNEATTAAEEGEALQWVVGTEVDLISQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLTDTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGDRIAQSAELADREKITGQLASLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIVRHKAL-------------------------------------------------------------------------------------------------------------NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYVDITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEQELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLISDTVGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFATCGEEQKAVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRTLIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVEEKYQKAENMYAQIKEEVRQRALALDEATSQSA---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECINDNKSATMELEKLQPSFEALKRCGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIRDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVHYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLN---EMKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAYRQHKLEGALLALGQFQHALEELMGWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTLQ-QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWRVVSSKLEERKLKLEEALSLATEFQNSLQEFINWLTLAEQSLNIAPSPSLILNTVLSQIEEHKVFANEVNAHRDHIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLADDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNVEPAHAPFIEKSRGGSR---KPLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKI-------------------------------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRTPAPK

PF00681 // ENSGT00760000119163_1_Domain_15 (2758, 2789)

ILE
GQVVTGGIIDLKRGKRVSVTLASNLGLVDITDQTELINLEKAFKGKDTEKPIRERLIRLQ
METTGFMDPDSKVPLTIVESIDRGLLEKEEAVH

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2892)

LLTKQVVNGGIVHHTSGMRLTVDNAYK
HGLIGEDLAKQLKKVENVNLHQFFHPETKEALSLPEAIKLNLVAPDVKKEIQEIQTFNEN
FVDLISGQRLTVAEANKKGLLT----NKAISSSGMMHGVIDPENYKIVPYSELVKKCKID
IESGQRYLEVIPFSDIRDGVSDKVLSLSEAIQLGKVDFVSALK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3081)

VLEAQANTGGIIDTATG
KKLTLASALEQKLLDENMARIIAS-----HQVLSGGIVDIFNDERVTLKEAVQKGLISPE
LATVIHTDTVKS---------EQDD-IEVCESEDEFLRKEKLIVYSQIAKMSC--DKGES
EKLF-A------QEKFEGKVSNGK-------QTRKKREIS--EFKGKDCEKGRASPD---
TIGSVSDIIPSSINMKSA--SPVSVPHSH--SEVANFKLS--GAGNMGKNTN----VEQE
KVMPQIETLTHMKKS-SLDLDAEDATEN-QEVIS-EVQE-FNRKPP------GKFLNEQ-
---PVNT--REKSKRE-KETTVEKSVNSCKSAAISEKKLTQKTADRDEHKSNKKKQSMEM
VKGEKEKEA-DRDKELSVICKTEDFSS-QMTPKGISVKNQDALTFFTSTPM----SEEER
K-----------NVSLCLTFKTGENLSKKIDVGAQS-EPFSSVTPTS-EESDFQQLVGKP
QITDTSQMSK-TDNIVQRATRQETNFYQG-SCVTLETKETK--DLIFP--------LQEK
S-DQELPFDSKSA-------------------LKL-GK-FTVSRIDPNEVSYLESSDRKD
LHYQDSKDDLELSEILKSK-I-AVTQETNGEKFQEV-NPV-VTGPET--GSLEGIVTQKV
PRDLVSLVPEKLF--KDVS----EKVSAVQQGVI-VALSALETSEEMA-LPLTK------
DG--------------KTPQ-----KELS---------EQ------SPSMAGPEGKGSRS
GDGNPQPL---RATQNVFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNLAELQDLVCQAKVIDRELQALSTLVSQELECVNQIIVSQPQEVPTQLLKALEKDA
KNLQKSLSSVSNTWSTRLLHLQNAV-EVKKTTVLNQHTQLESELQDLRAWVGDTSVILNN
KECNSE--A-DVISLSHSLQQYKDLKQPMAERKSQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQKSFQDLVDWTAAQTDALQGRLQQVQKEAQVK-TLQQQQNTCHQKLEDLCS
WVGQAERALESHQ-GRASHQELSALQKNQSDLKDLQEDIQNHTTAFTTVVKDIEVFLEEN
QTKLSPQELTALQEKLHQAKEQYEALQEQTRVAQKELEEAVSSALQQETEKSKAAKELAE
NESKIDALLNWVTSVG----------S--SSGHQQTTLPGMKQLSGAS--PMQGTLDTTD
GH-MGVNHAPENLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLEQHGHNLTPEEQQNL
QEKLGDLKEQYAASLARSEAELKQVQTLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4519)

ELQKFLQDHREFESWLERSEKELENMRMGT
IG-PEALPSLLKQQGGFSEDVISHKG-DLRFVTISGQKVLDA-ENSSEESKEPS---TTS
DLVKERLKDATERYTALH

ENSGT00760000119163_1_Linker_24_25 (4519, 4535)

SKCTQLGCHLNMLLGQ

PF00435 // ENSGT00760000119163_1_Domain_25 (4535, 4646)

HQQFQSSADSLQSWMQACDANVKKLL
SDTVASDPGVLQQQLAMT-K--KLQEELAEHQVPVEKLQKAAHDFMEIEGEPAVDPKHVQ
E-TTDFILSHFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEVEQVTS
LSSGVIQEALANNMKWKQDIARQRSSLEATREMVTQFMETADSTT-AAVLQGKLAEVSQR
FEQLLLQQQEKESTLKKLLPQAEMFEQLSDKLQQFMESKSRMLASGNQPDQDIAHFSQHI
QELTLEMEDQQENLDTLEHLVTALGSCGFSLNLSQHQNKIQNLKKDFTKLQKTVQEREKD
ASSCQEQ-------LDEFRKLIRTFQKWLRETEGNIPPLETFISAKELEKQIEHL-----
-KD-----LLDDWTSKGTLVEEINHKGTSLENLITEITAPDSPAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNVKYEKLGGVLRDRQDSLQAILS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEASAVLQ
WLESKEEVLKAMDATLSPTKTETVTAQAESNKAFLAELEQNSPKIQKVKEALAGLLMTYP
NSQEAENWKKMQEELNSRWERATEVTVARQKQLEESASHLAGFQSAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLREFEARKQQHEQLNEAAQGILTGPGDVSPSTSQIQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDNEIKEAQTLCNELSVLIGEQYLKDELKKRLETVTLPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
IQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQMVELKSHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKLSELQVTLDPVQLESGLLRAKAM
LSEVEKRRSLLEILNGAADILINSSETDEDGIRDEKAGINQNMDAITLELQAKTGLLEEM
SQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLLQAEVIQQEFLEVKQRVTSGCMTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVWLFLNKIQAVKFDIEASEAECQQMLE
EEGTLDLLGLKRELEALNKQCSKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKALNEATTAAE
EGEALQWVVGTEVDLISQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLTDTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGDRIAQSAELADREKITGQLASLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6227)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIVRHKAL----------------------------------------------------
---------------------------------------------------------NEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYVDITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEQELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLISDTVGQRVDEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFAT
CGEEQKAVLQEKTESLIQQYEAISLLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRT
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVEE
KYQKAENMYAQIKEEVRQRALALDEATSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECINDNKSATMELEKLQPSFEALKRCGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIRDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6805)

DAMQAAVH

PF00435 // ENSGT00760000119163_1_Domain_44 (6805, 6910)

YQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLN---EMKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAYRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMGWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWRVVSSKLEERKLKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7137)

EALSL

PF00435 // ENSGT00760000119163_1_Domain_47 (7137, 7240)

ATEF
QNSLQEFINWLTLAEQSLNIAPSPSLILNTVLSQIEEHKVFANEVNAHRDHIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLA
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNVEPAHAPFIEKSRGGSR---KPLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKI-------------------------
------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PAPKR

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVVMSGLIAPETSEKLSLEEGLARNLINPQLYQHLWEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

EDALSLISR-R--
-QD---PFSVVEAVEKKIITEEIG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKILEAHLATGRSSLLYNEKYISLGEAFQQGLISAW
LHAVLESHLRSSKNLIDPNTAEKIGLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSGQ
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIVDPRTGHRLTVEEAIRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CAIL
IRQLQTGGIIDTVTGHRLTIDEAVSQDLVAAKIALVILES

ENSGT00760000119163_1_Linker_11_12 (2141, 2146)

LWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2179)

GLLWPESGEILPITD
ALEQGIVSTELAQKILIG

ENSGT00760000119163_1_Linker_12_13 (2179, 2641)

RQHIKGLFLPTTTEIWSWEEATENGILDKDLANKLKSICIPD
VMPHMQLADSSEQSKLSIYHSMAEL---QCSKVQT-----QG-IASHSEK-LLFQLMTHS
YINVQNGQRLLLLDNELIETLT----CGDNQASPP---EGFGLKHQELETPKELQE--PV
DVKITDT-FYDGLTERPYELQLCSQNIEYPDQANCTEAKSKKAIIKVEVPS--------K
ENLRKDL---EEKLQNPNVDTLK-VINKVKSELKRQLLKTKKEDQTTVSTRED-----GN
RKIVLTVS-PEKANET-VVVDKD-PSVETPREEWQAL--KKISYLGQKEEA--NMSETKY
IPCEIGKPL---INYQSKTSQLQVE-NILNLELEPKCEKDTDTHSQDKKKASDKTFS---
----GMDD--HKQSQEGHNIA-GDSTSILRKRDKEDDDSETFLSCS----HPSVLLEDAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2685)

LNLLSSQLLDGGIFHEQTGQKFLLNEAIAQGIVPSHTAVKLMAK

ENSGT00760000119163_1_Linker_13_14 (2685, 2718)

LNMFRGFFDPQTCEFL
TTEEVIEEGLMDANLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2755)

HNVLMADKTISGVLDPRTHTLCSVKEAVEVGLLDTHT

ENSGT00760000119163_1_Linker_14_15 (2755, 2756)

A

PF00681 // ENSGT00760000119163_1_Domain_15 (2756, 2800)

ARILE
GQVMTGGIVDLKRGKKVSVTLASNLGLVDSADQTELLNLEKASKGRETKKTVREGLIDLQ
METTGIVDPNNKIPLTVVQSIDRGLLEREEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

IQLLTKQIVDGGIIHHMSGMRLSVDNAFK
HGIIDEDLAKKLRKV

ENSGT00760000119163_1_Linker_17_19 (2896, 2929)

EDLNLHQFFHPETKRTISLVEAIKLNLVTPELK

PF00681 // ENSGT00760000119163_1_Domain_19 (2929, 2983)

REVQEIQALTGS
FVDLISGQRLTLAEVKKEGLLL----NKASLSSGMVHGIVDP

ENSGT00760000119163_1_Linker_19_20 (2983, 3041)

ENYRIVPYSELLKKCKID
IESGQRYLEVIPFSDIKDGVSDKALTLTQAIQLGKIDFSS

PF00681 // ENSGT00760000119163_1_Domain_20 (3041, 3091)

TLK-LEAQANSGGIIDTTTG
EKMTLASALEQNLVDENMVRIIAS-----HQMLNGGIVDIFSDQRVTLEEAIEKQFISPE
LATMIQIDILESSEHG-VEIEKQDE-VKVCELKKECLRKEVLTDCNQTGKMSC--REDER
EKSF-QTDNLSPKEKVRAQISNEE-------QAKMSREISLRELEFKDEDKRRISID---
AKELVSSTVPSGLKGKSL--SRIALTHPQ--SDVHEFKLKEWARNNMEKDRN----KEQE
KTVTQTETSYHMKQA-ALGLDSKEIRENQGEIIS-ELQELS-CETP------DKQLIGKI
VQTPITT--RSRSKRKMRGVITEES----KLAVLSKEELDQDSVIRDDHDTIIKSPPMEI
IVSGKGKEV-DRELEFSITCEAKDSSS-QMVPKEISITNQGALAF-NSNQV----CEGEI
K-----------DLSFFLTSKREKKKFPAITGGC------------T-SALHYKKTAGKV
QHADTSSISK-KEKSFQGTTGQETNYYQD-SCVTFKTKQAK--DMIFS---S-NE-HKEK
S-LQ-IPVDSTRA-------------------FKLQEE-IKISRVDPKENNYPVSSDRKD
LHHQDRKNDQELSDILKSK-I--VTTQEVTRKKFLETANPIKTGTEA--GSFEGIVTQED
NRVLASFHPEKLF--KE---------SLEHQDAT-ISPTTPGIREEKT-VLITSFPAMKI
NE--------------KISQEKLGESPHN---------KQ------PSFVTASREKGDES
T--DPEPF---RATKNLFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPQ--
--ELNLTELQDLLCQSKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX
XXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQAQVK-TLQ

PF00435 // ENSGT00760000119163_1_Domain_23 (4126, 4239)

KQQDICHQKLEDLCS
WVGQAERALVSHQ-DRANKQGLSALQKNQSDLKDLQDDIQSHATSFASVVKEIEGFLEEN
QTKLSPHELTALREKLHQAKEQYKALQEQARATQKELEEVVTSALQQETEKSKAAKELAE
NRSKIDALLDWVASVE----------S--SGG-------QMEPLSGAS--SQKDTLDVTD
GH-KGVDQAPEELDKQCEKMKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXKRQGSFSEDVISHTQERVRFVTISGQKALDS-VNSFEEGRQSS---VTG
TLVKEKLKDATERYTALHSKCTQLGSHLNILL

PF00435 // ENSGT00760000119163_1_Domain_25 (4533, 4647)

GQYQQFQSSADSLQAWMQACEANVKKLL
SDTVSSDPVVLQQQLATT-K--QLQEELAEHQVPVEKLQKVACDLIEIEGEPAPDRKHVQ
E-TADSILSHFQSLSSSLAERSAVLQ

ENSGT00760000119163_1_Linker_25_26 (4647, 4650)

KAI

PF00435 // ENSGT00760000119163_1_Domain_26 (4650, 4757)

AQSQSVQESLESLLQSIGEVEKNLQDQQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSST-AAVLQGKLAEVNQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFVENKSRMLASGNQPDQDIAHFFQQT
QXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----
-XG-----LLDDWTXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXX
XXXXXXXXXX-XLTEIQCDMSDVNLKYEKLERVLEKRQESLQTILSRTQEVQKEANSVLQ
WLESK-EVLKAMDTTSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLRTYP
DSQEAENWQKMQDELXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXFMLKEFEARRQQHEQLNEAAQGILTSPGDGSPSTSQVQ
EELQSINQKWVELTDKLNSRSNQIDQAIVKSTQYQGLLQDLSEKVKAVGQRLSSQSAIST
QPEAVKQQLEETSEIRSDVEQLDHEIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAA

PF00435 // ENSGT00760000119163_1_Domain_31 (5364, 5472)

LAST-QFQQMFDELRTWLDDKQNQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKKTLQNQLVELKSHWEELS
KKTADRQSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVEDLVPWIEDCKAKMSDLRVTLDPVHLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNIDSITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQTLEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCMTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDSDSLQSQIEDVRQFLNKIQALKLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERSKARQEQLELTLGRVEDFYRKLKELTDMTTAAE
EGEALQWVVGSEVDAINQQLADFKXXXXXXXXXXXXXXXXXXXXXQGLIQSARKDCDVQG
-EHDMEEINARWNTLNKKVAQRIAQLQEAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRRATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTGLLNKAAAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXALEEEIESHATDVHQAVKIGQSLSSLTCSAEQGVMSEKLDSLQARYSDIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXAFSIDIIRHKDSMDELFSHCGEIFGT
CGEEQKAVLQEKTDSLIQQYEAISLLNSERYARLERAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELSPWIEETQA
LITXXXXXXXXXXXXXXXXX-XXXQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENIYAHIKEEVRQRALALD

ENSGT00760000119163_1_Linker_40_41 (6565, 6571)

EAVSQS

PF00435 // ENSGT00760000119163_1_Domain_41 (6571, 6688)

AQVLQ-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QSAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIQEPLTELKHLWENLGE
KIAYRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLKKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

STLQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMETQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEDHKVFANEVNDHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVPHCIERGRSLDDARKXXXXXXXXXXXXXXXX
XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXGGKQPVYDT--RTGSAPKEQTLLP
GDTQK-DNLFGDVRDKWDTVCGTSVERQHKMEE

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

LLLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTDALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLE

ENSGT00760000119163_1_Linker_50_51 (7579, 7582)

TAL

PF00435 // ENSGT00760000119163_1_Domain_51 (7582, 7720)

SELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQAFMEEMTRKQPDVDRVTKTYKRKNVEPTHAPFIEKSRSGSR---KSLNQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLN

ENSGT00760000119163_1_Linker_51_53 (7720, 7763)

DALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRSP--FVLQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPGSGT---------------------------
----------KVIPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRA------
------------------------------------------------------------
------------------------------------------------------------
-----

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVIMSGLIAPETSEKLSLEEGLARNLINPQMYQQLREL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

QDALSLISR-LTE
GRG---SLCVVEAIEKKIISEKVG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKILEAHLATGGFSLPPHDNRINLGEAFHQGLISSW
LHSVLESHLRSSKNLIDPNTAEKISLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIVDPRTGHRLTVQEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CALL
IRQLQTGGIIDTVTGHRLTIDEAVSNDLVAAKIALVILES

ENSGT00760000119163_1_Linker_11_12 (2141, 2146)

LWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2179)

GLLWPESGEILPITD
ALEQGIVSTELAHKILSGRQHIKALFLPATTEIWSWKKAIENGILDKDLANNLKSICIPD
VMPHMQLADSLERSKLSMNPGVAGL---LCSQGQT-----EG-IASPNEK-LLFQLMTHS
YVDVRNGQRLLLLDNELIDALT--AGG-ECQAGPP---EMFEIGHQRLETPEELQE--SV
NVKITEA-FCDGLTVRPPEFQFSSQNKEDPDQANCTEAKGKKTTVETE-SS--------A
ENPKEDLFVGKQKVEIPNVNTLK-VIGKVNSEFTRQLSGSKKQDQIEVSTREN-----AS
RGVLLTVP-PEEAEDVTLVEDKD-PSVESPKEEWQTL--RKTSFMCQKEQA--NTLETEY
TLSETGRPL---KKPQSKKSQFQVE-RTLVLESEQTSEKDKSIHSLGKKKALNKTSL---
----GRDD--HKQSPEGHSRA-GGRMVMLGKTDEEDSGHETSLSCS----HPLELLE-AT
LNVLSTQLLDGGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXX
XXXX-XXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXX----XXXXXX---
XXXXXXXXXXXXXXXXXX--XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX----XXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX-XXXXXXXXXXX------XXXXXXXX
XXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX----XXXXX
X-----------XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXX-XXXXXXXXXXXXXXXXXX-XXXXXXXXXXX--XXXXX---X-XX-XXXX
X-XXXXXXXXXXX-------------------XXXXXX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX
XXVSMSLLPKKLL--QDVS----PKESTGQQAAT-SSPTIPESSEKDT-VPLIACPAVKM
DE--------------KTPQERLRESPGS---------EQ------TPFVTAPGGKGNDS
V--NPEPF---RATKNVFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNLAXXXXXXXXXXVLDGELKDLSTLVSRELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDSWSSRLLHLQNAV-EVKKTRVL

PF00435 // ENSGT00760000119163_1_Domain_22 (3995, 4109)

NQYEQLESKLQDLRAWVGNTHLLLNS
KDYDNE--T-DADSLNHNLQQCEDLKQSMVERKSQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQDLVEQTAAQRDALQGRLQQMEQAARVK-XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSKTAKELAE
NRSKIDALLDWVASVG----------S--SGG-------RMEQLSGAN--LEEGALDTTD
GH-TGVNQAPEKLDKQCEKMKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX---XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-X--

PF00435 // ENSGT00760000119163_1_Domain_25 (4583, 4647)

QLQEELAEHQVPVEKLQKVAHDLMEIEGEPAPDRKHVQ
E-TTDSILSHFQSLSSSLAERSALLQKAIAQSQSVQESLDSLLQSIKEVENNLEEEQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FQQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQI
QELNLEMEDQQENLDTLEHLVTDLSSCGFALDLSQHQDRVQSLKKDFAELQKTIKERGRS
--SCG-----------DERKLIRTFQKWLKETEGNIPPTETS-STKDLEKQIEHL-----
-KD-----LLGDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLREHQESLQAVL

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

SRMQEVQKEASSVLQ
WLESKEEVLKGMDASSSPTKTETVRAQAESNKAFLAELEQNSPKVQNVKEALAELLKTYP
NSQEAEYWKKVQEELNSQWERATEVTMARQRQLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5138)

ESA

PF00435 // ENSGT00760000119163_1_Domain_29 (5138, 5246)

SHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILAGPGDGSPSTSQVQ
KELQSINQKWIELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDVEQLDHEIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLNDRQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKKTLQNQLVELKSHWEELS
RKTADRQARLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVEDLVPWIEDCKAKMSDLRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKARINQNMDSITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEALQALHPQVRY
LRDFTQGLVEDAPDGSDASQLLNQAEVAQQEFLEVKQRVNSGCMAMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAVGRDADSLQSQIEDVRLFLNKIQALKLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERSKARQEQLELTLGRVEDFYRKLKALNDMTTAAE
EGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEEIESHAADVHQAVRVGQSLSSLTCSTEQGVLAEKLDSLQARFSEIQDRCC
RKAALLEQAL

PF00435 // ENSGT00760000119163_1_Domain_37 (6131, 6237)

CNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE

ENSGT00760000119163_1_Linker_37_38 (6237, 6240)

QAR

PF00435 // ENSGT00760000119163_1_Domain_38 (6240, 6346)

Q
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMERRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID

ENSGT00760000119163_1_Linker_38_39 (6346, 6349)

AAI

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

QRSQQYEQAADA
ELAWVAETKRKLMALGP-----------QLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAILQEKTDSLIQQYEAISLLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENTYAQIKEEVRQRALALD

ENSGT00760000119163_1_Linker_40_41 (6565, 6571)

EAISQS

PF00435 // ENSGT00760000119163_1_Domain_41 (6571, 6688)

AQITE-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREMKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIQ-QVEAAGTIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWRERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

SALQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMETQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIDRGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAESHLDSEXE------------------EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

RQAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDAEALQSLIDTHKKYMKKVEEKRVDVIPA-VMGEVILTVCH-LCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLE

ENSGT00760000119163_1_Linker_50_51 (7579, 7582)

AAL

PF00435 // ENSGT00760000119163_1_Domain_51 (7582, 7720)

SELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKVIEPAHAPFMEKSRGGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRRLN

ENSGT00760000119163_1_Linker_51_53 (7720, 7763)

DALDRLEE-------------
--------WN--KDRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDHDGKITRQEFIDGILP

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRMNIKTREKIILPEGASQGMNPFASRVRYXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------------------
----XPASGSKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTSRA------
------------------------------------------------------------
------------------------------------------------------------
-----

MGNSLGCFKEPKESIAIPEKAPISPKKRVRFKRRWRGKKIPTPEASHQEETSEGTEVIEE
TETLTKLTVSLQKEDGVGGVEHTPPDILLPGDSA-PNSQVVDQGMIVQVKERFQGEVQTA
HLLLENESSVAGGVWDSLEEGMTVIAHLLDNPAERNCEKSVSQLVEFPRTASCSSRAVLL
PLQGETAVEKGNIQLGFRSCALLRTDYPTDTGNQEQFSEGWSVEEGTKS-----------
V------------------------SGAPQTGSWIAECSVSSSLLDKPGGQRRTEPSHVG
LVPLQDSRLPTSQSDLSISGVTVSILPSSSGYGS--------------------------
-------------DGPHIHGIQPKDTE-----------PEKSSTSFSEEDGTLSLEASHT
PSWGLEEISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFA
SLELVPPST-------LTTTHLKAEPLTKAPYS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEVRSLQNPHYGRYVDGTDERTVHTIKL----------------YRSTRRS
ELVSSRCR--SKL-----KPSASINSGTFYF-PICLQLRAGIEKLFTQFSLSFSLCSTFP
FYISTLPFKKTIEWESSGIGFA--------------------------------------
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-----

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--------------------------------------MAGYVPGQQPANRSQEKE----
FVQAYEDVLER-------YKDERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 458)

QISDIYISGESGDMSAKEKLLLWTQKVTAGY

PF11971 // ENSGT00760000119163_1_Domain_2 (458, 510)

TGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKTTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKKNYFSELMMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GECHQVMQNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKAHFQRLVKSMENE
DKEETVAKMYISELKNIQLRLEECEQRLVKRIQSPASSRTDKDARQESALRIAEQEHTQE
DLQQLRSDLDAFSVKCNSFLHQSPSGSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTI
DVIMRSMQDAELLVKGYEIKLSQEEAVPADLSALESHRSTLRHWLSDVKDKNSVFSVLDE
EISKAKVVAEQLNRLTPERNLDLERYQEKGSQLQERWHRVI-AQLETRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-QTKES
TDIEKAILEQQVLSEELTTKREQVSEAIKTSQIFLAKHGHKLSEKEKEQISEQLSGLNKA
YRDLCDGSANQLQQLQSQLAQQTEQKGCRA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVITSGLIAPETSEKLSLEEGLARNLINSQMYQQLQELQDTLFLIHR-FTK
SQG---PLSVVEAIEKRIISEKVGLKILEAYLAAGGFSLSPGENCINLEEAFHQGFISAW
LHSVLESHLRSSKNLIDPNTAEKIGLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2100)

RLLEAQLFAGGIVDPRTGHRLTVHEAVRHNLIDQDMACAI

ENSGT00760000119163_1_Linker_10_11 (2100, 2102)

L
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2139)

RQLQTGGIIDTVTGQRLTVDEAVSNDLVAAKIALVIL

ENSGT00760000119163_1_Linker_11_12 (2139, 2146)

ESLWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2177)

GLLWPESGEILPITD
ALEQGIVSTDLAHQIL

ENSGT00760000119163_1_Linker_12_13 (2177, 2641)

SNRQHIKALFLPATTEICSWDKAIENGILDKDLANNLKSVCIPD
VMPHMQLADSSEQNNLSINSGAAAL---PCNKDQT-----EG-VANQREK-LLFQLMTHS
YINVRNGQRLLLLDKELMQTLA--SRDEAQ-TSAP---AVSGTGPQGLRTPEEFQE--SA
NVKITET-FSDGLTVRHDEFQFSSQNEEYSDQKAHTEVKGKKAAGEIACPS--------V
ENPEKDLFVGEERVRNPAVGTLE-VLSQVKSELQKQLIGVRKQSHTEMSTRDI-----VS
KG-LLTVP-PEETESVPSVVDEDLLSIETPKEEWQAL--RKISFTCQKELA--NPLEIKC
IPDETGEPL---IKPQSKKSQFQVE-KMLGLKSEPKSEKDMNIHCPDKQKVLNKTSL---
----SRDD--HKQSQEEANIS-DTCIKVLEKTNEEDDGIETSQSCS----HPSELPEEAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2682)

LNLLSAQLKKGGIFHEQTGEKLLVNEAVAQGIMPSHTAVKL

ENSGT00760000119163_1_Linker_13_14 (2682, 2719)

MGKLNMFRGFFDSQTSESL
TTEEVIDEGLMDEKLL-H

PF00681 // ENSGT00760000119163_1_Domain_14 (2719, 2760)

KVLMADKAVSGVLDPRTHTLCSVKDAVAVGLLDKETATRILEGQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQTELIKLEKAVKGRDAGKTVRERLISLQMETTGLMDPDRKAPLTVVESMDRGLLDREEALHLLTKQVVDGGIIHHTSGMRLSVDNAFQRGLISEDLAKQLKKVENLNVHQFFHPETKETISLPEAIELGLVNPDLKREIQEVQAFTENFVDLISSQRLTLAEAKKEGLLT----NKAVVSSGMVHGIVDPESYRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDEVSDKVLTLSEAIQLGKVDFESTLKVLEAQANTGGIIDTATGKRLTLASALEQKLVDENMARIIAS-----HQVLNGGIVDIFSDQRVTLEEAIEKRFISAELATMIKIDTLESSDHR-VQFEKQDG-TKVCELKDEFPRKEVVVACNENAQMSC--DKGENKRLF-QVKNESAPEKFKVKVSHGK-------QVKMSREISLKELEHKDQDPHRTPPD---ARESVSTITPSDPKREPL--GQVSVTHPH--SKVRDFKFKEGARHNKEK-NR----NEDQEIMTQIEIITHLKPS-APRLDSEDVRENQREMLS-GIQE-SDPEMS------GKLLSEQPV--NTSM--RSK--REK--MIVEESVKICKPAVLSEEELNQEIAIGDEPDSAIKSQPVEMTASEKGKET-IREKGFSVVCKIENSSS-QLIPKNISVQNQDSLTFFGSEQV----NVGELK-----------NVSPYLTLKPEANLSQEITSGVSR-ELFSSVIPRP-EELHYQDSVGKTQFTDTSQISK-VDKTSQATTGLQPNYYQD-SCVTSKTKETK--DLIFS---S-NE-YEEKS-YQEVPFNSTRP-------------------SEL-EE-IIVYKVNPKESSYLDLDGKGLYHQGCKGNYE-LA----------TTQEIAREKFPEAANPL-VTGSKA--ESLEGTVTQRGPTVLVTILPEKLP--KDVS----QKESTRQQDIL-FSPTTPETSEERP-MTLASCSVKKMDE--------------KTPQEKLRQSPVS---------EQ------TSFTTAPLGKGNEGA--NLEPF---RATQNVFN--------RRLCLEHDEKLVSYLSLLRNIEMRTRQIQPL----ELDLAKLQDLLCQAEVLDRELKDLSTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWSSRLLHLQNAM-EVKKTAVLSQHAQLEDKLQDLRAWVGSTSLTLSSKGCSNK--T-DPDSLNHSLQQFEDLKQPMAERKSQLDALAFDIQFFISKHAQDLSPQQSRQTLRLLNEVQKSFQDLVEQTAAQVDALQGRLQQVEQEAQVK-TLQKQQNTCHQKLEDLCRWIGQAERALEGQQ-DRGTQQDLSALQKNKSDLKDLQDDIQNHATSFATVVKDIEGFLEENQTKLSPQELTALQQKLSQAKEQYEALQEQTRVAQKELEEAVTSALQQETEKSKAAKELAENRNKIDALLDWVTSVE----------S--SCGRLQTSLPGMEQLPGAD--PEKRTLDTTDGH-MVVSHAPENLDRQCAKMKACHQELLSQQQNFILATQSAQAFLDQHGHNLEPKERQMLQEKLGELKEQYATSLAQSEADLKRVQTLRDELQKFLQDHKEFESWLERSEKELENMHKGSSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENNSEEGKEPS---ATRHLVKEKLKDATERYTALHSKCARLGSHLNMLLSQYQQFQSSADSLQAWMQTCEANVEKLLSDTVASDPGILQQQLLTT-K--QLQEELAEHQVPVEKLQKIARDLMEIEGEPAPDHTHVQE-TTDSILSHFHRLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEGKQVASLSTEVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSNT-AAGLQGKLAEVNQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFVENKSRMLASGNQPDQDIARFSQQIQEVSVEMEDQKENLDTLEHLVTELHSCGFALDLSQHQDRIQNLKKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLIRLFQKWLKETEGSIPPTETFLSTKELEKQIEHL------KG-----LLDDWVSKGSLVEEINCKGTSLENLIMEITAPDSQAKSGSIL---PPVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGLLQERQESLQAVLDRMDEVQKEANSVLQWLESKEEVLKTMDASLSPTRTETVKAQAESNKAFLAELEQNSPKVQKVKEALAGLLVTYPNSQEAKNWKEMQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIVTGPGDVSAATSQVQKELQNINQKWVELTDKLNSRSSQIDQAIIKSTQYQELLQHLSEKVKAVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDHEIKEAQALCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDNKQSQQAKNCPISAKLEQLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKSHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRITLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKTGINQNMDAITEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCMTMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVHLFLSKIQVLKLDIEASEAECRQMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAEQADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDVENHATDVHQAVRTGQSLSSLTCPAEQGLLSEKLDSLQARYSEIQDRCCRKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLRAVEDELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGTCGEEQKAVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAISQSA---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFDALKHRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLATMRDTQDIIHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLCEKIAHRQHKLEGALLALGQFQHALEELMSWLIHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTLQ-QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRGDSGSGSKTEQSVALLEQKWRVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPDDTQTLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLEAALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKTVEPAHAPFVEKSRSGSR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--SKPSKIPTMSKKTTTASPRTPG

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2794)

RILE
GQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQTELIKLEKAVKGRDAGKTVRERLISLQ
METTGLMDPDRKAPLTVVESMDRGLLDREEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2895)

LHLLTKQVVDGGIIHHTSGMRLSVDNAFQ
RGLISEDLAKQLKKVENLNVHQFFHPETKETISLPEAIELGLVNPDLKREIQEVQAFTEN
FVDLISSQRLTLAEAKKEGLLT----NKAVVSSGMVHGIVDPESYRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDEVSDKVLTLSEAIQLGKVDFEST

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3091)

LKVLEAQANTGGIIDTATG
KRLTLASALEQKLVDENMARIIAS-----HQVLNGGIVDIFSDQRVTLEEAIEKRFISAE
LATMIKIDTLESSDHR-VQFEKQDG-TKVCELKDEFPRKEVVVACNENAQMSC--DKGEN
KRLF-QVKNESAPEKFKVKVSHGK-------QVKMSREISLKELEHKDQDPHRTPPD---
ARESVSTITPSDPKREPL--GQVSVTHPH--SKVRDFKFKEGARHNKEK-NR----NEDQ
EIMTQIEIITHLKPS-APRLDSEDVRENQREMLS-GIQE-SDPEMS------GKLLSEQP
V--NTSM--RSK--REK--MIVEESVKICKPAVLSEEELNQEIAIGDEPDSAIKSQPVEM
TASEKGKET-IREKGFSVVCKIENSSS-QLIPKNISVQNQDSLTFFGSEQV----NVGEL
K-----------NVSPYLTLKPEANLSQEITSGVSR-ELFSSVIPRP-EELHYQDSVGKT
QFTDTSQISK-VDKTSQATTGLQPNYYQD-SCVTSKTKETK--DLIFS---S-NE-YEEK
S-YQEVPFNSTRP-------------------SEL-EE-IIVYKVNPKESSYLDLDGKGL
YHQGCKGNYE-LA----------TTQEIAREKFPEAANPL-VTGSKA--ESLEGTVTQRG
PTVLVTILPEKLP--KDVS----QKESTRQQDIL-FSPTTPETSEERP-MTLASCSVKKM
DE--------------KTPQEKLRQSPVS---------EQ------TSFTTAPLGKGNEG
A--NLEPF---RATQNVFN--------RRLCLEHDEKLVSYLSLLRNIEMRTRQIQPL--
--ELDLAKLQDLLCQAEVLDRELKDLSTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWSSRLLHLQNAM-EVKKTAVLSQHAQLEDKLQDLRAWVGSTSLTLSS
KGCSNK--T-DPDSLNHSLQQFEDLKQPMAERKSQLDALAFDIQFFISKHAQDLSPQQSR
QTLRLLNEVQKSFQDLVEQTAAQVDALQGRLQQVEQEAQVK-TLQKQQNTCHQKLEDLCR
WIGQAERALEGQQ-DRGTQQDLSALQKNKSDLKDLQDDIQNHATSFATVVKDIEGFLEEN
QTKLSPQELTALQQKLSQAKEQYEALQEQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NRNKIDALLDWVTSVE----------S--SCGRLQTSLPGMEQLPGAD--PEKRTLDTTD
GH-MVVSHAPENLDRQCAKMKACHQELLSQQQNFILATQSAQAFLDQHGHNLEPKERQML
QEKLGELKEQYATSLAQSEADLKRVQTLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4523)

ELQKFLQDHKEFESWLERSEKELENMHKGS
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENNSEEGKEPS---ATR
HLVKEKLKDATERYTALHSKCA

ENSGT00760000119163_1_Linker_24_25 (4523, 4534)

RLGSHLNMLLS

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQAWMQTCEANVEKLL
SDTVASDPGILQQQLLTT-K--QLQEELAEHQVPVEKLQKIARDLMEIEGEPAPDHTHVQ
E-TTDSILSHFHRLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEGKQVAS
LSTEVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSNT-AAGLQGKLAEVNQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSDKLQQFVENKSRMLASGNQPDQDIARFSQQI
QEVSVEMEDQKENLDTLEHLVTELHSCGFALDLSQHQDRIQNLKKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLIRLFQKWLKETEGSIPPTETFLSTKELEKQIEHL-----
-KG-----LLDDWVSKGSLVEEINCKGTSLENLIMEITAPDSQAKSGSIL---PPVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGLLQERQESLQAVLDR

PF00435 // ENSGT00760000119163_1_Domain_28 (5028, 5135)

MDEVQKEANSVLQ
WLESKEEVLKTMDASLSPTRTETVKAQAESNKAFLAELEQNSPKVQKVKEALAGLLVTYP
NSQEAKNWKEMQEELNSRWERATEVTVARQRQLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5143)

ESASHLAC

PF00435 // ENSGT00760000119163_1_Domain_29 (5143, 5244)

FQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIVTGPGDVSAATSQVQ
KELQNINQKWVELTDKLNSRSSQIDQAIIKSTQYQELLQHLSEKVKAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEIKEAQALCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDNKQSQQAKNCPISAKLEQ
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKSHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRITLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKTGINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCMTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVHLFLSKIQVLKLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAEQADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6128)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDVENHATDVHQAVRTGQSLSSLTCPAEQGLLSEKLDSLQARYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLRAVEDELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKAVLQEKTESLIQQYEAISLLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAISQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFDALKHRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLATMRDTQDIIHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6802)

DAMQA

PF00435 // ENSGT00760000119163_1_Domain_44 (6802, 6910)

AVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLCE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLIHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRGDSGSGSKTEQSVALLEQKWRVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQTLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLEAALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKTVEPAHAPFVEKSRSGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7944)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--SKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------DERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGVKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 443)

QISDIYISGELGDMSA

PF00307 // ENSGT00760000119163_1_Domain_2 (443, 543)

KEKLLLWTQKVTAGYIGLKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEIAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISAIEVDSRWLEYQTRVESLISWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEIPAKEQEKGQIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKLLRPAVERLELLLQIANKIQNGALSCEEKLTLAKNTLQADAAHLESGQPVQYESDV
VVYLQECEGLLRQLQVDVQILRDENYYQLEELVFRIMRLQDELVTLRLECTNLYRKGHFS
TLELVPTST-------LSTTHLKGESLTKGLHT--------------SSASWFRKPMTRT
ELVAISSSEDEGSLRFVYELLAWVEEMQMRLERAEWGTDLPSVESQLETQRHIHASVEDL
GSSVKEARMYEGKMSPNFRA-SYTETLGKLETQYCKLMETSSFRLRHLQSLHGFVSRATA
ELIWLNEKEEEELAYDWSDNNPNIAAKKNYFSELTAELEEKQ-DIFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVHTQWQWIKQLCLCVEQHVKENAAYFQFFSDARESETYLRNL
QDSIKRKYSCDHNTSLTRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLRPRNP
EQAVKSTIPIRAVCDYRQIEITICRNNECVLENNSQRT--KVISPTGNEAMVPSVCFLIP
PPNKEAIEMASRVEQLYQKVMALWHQLHMNTKSLISWNYLRKDIALVQSFSMEKLRSLAQ
GECQQALKSLQA----HYEDFLQDSRDSELFSVSDRLRLEEEVESSKEHIRQLLESMENE
DKDETLARSYLSELKNIRLRLEECEQRLVSRIQSPSSARADGDTIQENAIRMAEQERTQA
DLQQLQSELRVVSQRCCSFLDKAPAGPSTPHLRSELDLVVNKMEQTHGLSSIYLEKLKTV
DIIIRSTQGAESLVKGYEVKLSQEEAVPADLAAIQTHRAALQQWLGEVKDKGSVFSTLEE
EMAKAKEVGEQLLRLRQERSIDLERFQEKGSQLWDRWQRAC-AQIETRHTELESIQEVLS
DYRQCHRALIQWIEEITAQQELMKPGQAEDSRVLSEQLSQQTALAAEIEKNQAKLDQCQK
FSQQYSAAVKDYELQLMTYRAFVESQQKSPMKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVDKVKELLGWALGLKQSVQGRTAAA-GSREL
GDIEKSISEQQALNEELTAKKEQVSEAIKTSQIFLAKHSHKLSQLEKDQISAQIDALKET
YQALCSNSTEQLQQLQSQLAQETEHKGS

PF00681 // ENSGT00760000119163_1_Domain_6 (1829, 1870)

EA--VAGVIDLGT--VEIFPVFGAMQRGLIDQ
DTGLALLEAQVISSDLVVPETSEKLSLEKALARNIIDLRAFQVLQELKDALQQVEEIRCEGRQ---LLPVVAAIEEGRISESHGLKILEAELITGGFKFQQGR--ISMETAVQENLLPTQLHSRLLSHLEGGKDLIDPNTAEKISLPELLERCIIHQETGLRLLPVKQLAGGMVSLRSGREVSIFRAVQEGLIDRQVTIRLLEAHLFAGGIVDPRTGHRLTVDEAVRHNLIDQDLACTLLIRQLQTGGIMDSVTGERLTVDEALRKGLVAPRIALLVLESLGSFVGLLWPETGEIIPVADALEQGILSTELIQEVLSKRQLLQAVLTPDTTEVMSWQEAVERGVLEREVVKKLKSMAIPDVMASVQLAGSPSRSRHSHSSPGRSP---TG---QE-----EPLLRSDDEK-LMFHLMTHSYINIHDGQKVLLVDAELNNLTK--TLIQSQ-ENGS---CFE---------ETQADR--ALESEPC-----NGVALQQLELQFAPSKGESEKILSPRTALENGEVVVGPESLL-------LEDAEDFLRVEEQEQISTEQEITR-SEADAEF------------GKEHITFTAK-----DKHQVKLLMP-EPPSDLDSGLIRETEEVMVEAEEESKPP--AVDGVEGPEHQK--KELESGAVVVKSEISITMGVPESRDSLKIMAE-RSQGVREPEREAEDVREVYLPKEGTAENGVL-------EGEE--RQSTDMETVLKVEE--GEWEEVLGDEG--VEEPSLP----APEEQEAEDTLEKLLMQLQSGGIIHEQTGRALLLDEAVASGVVSGHTAVKLMERMKMFSGFFDSQVCESLTTEDVIEEGLMDEKLL-QKVLASDKAISGVLDPGNNFVYSIKDAAAVGLLDKETAMRILEGQVVTGGIVDLKRGKKVSVTLASNLGLIEPTGRTELVKLEKASKGKGSDEVTRQKLINLQAETSGIADLETKRPLTVAESVEKGLLEKEEAFQLLTKQVADGGIIHHVSGMRLSVDSAMKHGLINPDLCKELRKAESVVRQDFVHPATKEKLPLPQAVSLGLLSSEFQRKVQEIQAESGSILDPASGQRLALSQAVQEGLVV----EKALASPEMREGIVDPETCMVVPYSEFLKKCKIDIESGQRYLEVHPFQAIRDEVTGTKLPCAEAVRLGKVDPLPALRLLQAQADSGGVVEGSVSQRLSLRAAVEQGMLDEPMAKVIAT-----NQLRAGGIVDALGGKRLTVKEAVGKGLISQKLAAGLQDVEIPD---------EEVG-SEVCKVGKRQLSQEKVEKLSPKEE--------G--VTP-E------HPSVLGTASLPEGAESRGEVDGETEKIERLGLEKEQRRDDQCGPGD--SSSSVGICHRAAFQETAL--SQKSLQK-------SSSFLLWVPEPKPESSIETAAGLARDTAK---HKGGKGKKT-IPGKDTETPREDQGFPVPPEHGE-TQEERSGIRLRAGSILIQCRQRR--------------------GGGGQCQPEAVPEGSWLISQKL----AAGL--RDLEIPDEEVG----------SEVCKVGKRQLSQEKVEKLSPKEEGV--IFPARSARSDGAEPKAQPEPWWKKGSQKAAPNCSWAQRLTSVVQE-TPAAL----RESVTVGPGKGGMGPAESGEPPEVDVPVGDELGGKKAVKHTERETSPTEG-PIDQEKTSET---ELKPT---QKKKSKKKKAKQGSIPGDSTQPEKPAEKQLLPSLGGKGKKTIPG-KD-TETPREDQGFPVPPEHGETQEVVKGGIKDGHDSLVA--LS-L-EERMAQDDTRVETTWDVS-STATMA--QELPSDLIITEEPTEVQETSAKQH-------------EQRAELRA-DQAPAPPKS-----------------Q--------------EEPPQERSKQPGP---------GD------RGLLLPVIVEGELLET-SREST---RPAQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA----EQNLAALHDLRQQAEALGAELQELSFSVNQELDAVQRIVANPPEEVPEQLLKALEKDAKNLQKSLGSASEVLQSRLQNLRGAA-EAEKAKILAHHEALQGRLQELLSWVSGTAASLGDGDLQPA--T-DASSLSHCLQHYEELKEPLAATKAELDATAFDIQFLISEHAQDLTPQQSRQLLRLLNELQKAFRDLSERVTARLEVLQVCLQQVEQTEQVK-TLQEQQAARARSLAELSRWLGQAEDTLAEQQ-RAE--GDLPALQQRQSDVKVTQGFQVIITAS-LTLPKGGPLMGEDCQSHPSPFGVGALEARLRFSTASLY-LPESHKGSLLNMQELGHSYLEPLCFQVKAAKELEENSNKIDSLLDWVASLE----------E--KGALPEYRPHPVHQGTGTP--AGKSTGDVPDGHAVGADSAAESLDEHYERLKAQHQELLSQQQDVILAWQAAQAFLDKQG---PGEERERLRARLAELRERYPASLARAEAPLK-AQLLREELHKFLRDHGEFEACLEQAEQDLQGMCKGDSD-PASLRQLLRRQGSFSEDVISH-G-DLRFVNMSGRKFLD--GDAGDAESHLL---MSRRVVKSKLEDATQRYTTLHSKCSKLGSHLNTLLDHYQQFQEVAESLRMWLQESEAALGKLLSETVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQE-TTDAIVSRFQSLSQQMSERSDLLQKSIAQSQSVQESLESLLQSVAEVEKNLEKDQPAVLSSASIQDSLATSVKLKQDIARQRSCLEATREMVTRFTEAADSPA-ASALQDKLAQVTEHFGRLCQQQQEREDTLKGLLPTVEQYEQLWERLQQFTESRTRMLASGNQPDRGIAHFSQHIQELNSELRQHQEDLATLEHLAEELSSCGFAPGAFQQQEKLQSLKKDFLQLQKVAKDREKDASSCQEQ-------LDEFRDLVGAVRKWLRESEGKIPPAETSLGTQELQQHRQQI------QD-----LLEEWKGKGPQVEEIGRRGTLLENLIVEITAPSTPPKAGATL---PTPGGSGGSVNGYHTCK-DLTEIQCDVSEVRRRYQALGAALRERQQQLSAMLDRMQEVQEEASSMLKWLESKERMLSELEASSSPTKTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYPDSPEAANWKKMQEDLNCRWERASQATAARQQKLEESASQLATFQATEAQLRPWLMEKELMMSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSTSQVRDELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAISTQPDAVKQQLEETSEIRSDLEQLEEEISEAQNLCDDLSVLIGEQYLKDELRKRLETVALPLKGLEDL------AADRMNRLQTALASSQQFQHMFDELRTWLDDKRCQQAQSQPISAKLERLQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELSKQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADILTDASQTDEDDIRDEKASINQKMDAITEELQTKTGSIEEMSQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQTLEPQVEYLKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKVNDCCALMENKLEGIGQFNSRVREMFSQLADLDDELDSMGPIGRDSDSLQSQAEDVRAFLGKLQRLKSDIESSESECRKMLEDEGSPDLLGLKRELETLNKQCSKLTERGRSRQEQVETTLSRVEDFYSRLKELSRMTAAAEEHEALQWVVGTEVETINQQLADFKV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1906)

LALLEAQVISSDLVVPETSEKLSLEKALARNIIDLRAFQVLQELKDALQQVEEIRCE
GRQ---LLPVVAAIEEGRISESHGLKILEAELITGGFKFQQGR--ISMETAVQENLLPTQ
LHSRLLSHLEGGKDLIDPNTAEKISLPELLERCIIHQETGLRLLPVKQLAGGMVSLRSGR
EVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2100)

IRLLEAHLFAGGIVDPRTGHRLTVDEAVRHNLIDQDLACTLLIRQLQTGGIMDSVTGERLTVDEALRKGLVAPRIALLVLESLGSFVGLLWPETGEIIPVADALEQGILSTELIQEVLSKRQLLQAVLTPDTTEVMSWQEAVERGVLEREVVKKLKSMAIPDVMASVQLAGSPSRSRHSHSSPGRSP---TG---QE-----EPLLRSDDEK-LMFHLMTHSYINIHDGQKVLLVDAELNNLTK--TLIQSQ-ENGS---CFE---------ETQADR--ALESEPC-----NGVALQQLELQFAPSKGESEKILSPRTALENGEVVVGPESLL-------LEDAEDFLRVEEQEQISTEQEITR-SEADAEF------------GKEHITFTAK-----DKHQVKLLMP-EPPSDLDSGLIRETEEVMVEAEEESKPP--AVDGVEGPEHQK--KELESGAVVVKSEISITMGVPESRDSLKIMAE-RSQGVREPEREAEDVREVYLPKEGTAENGVL-------EGEE--RQSTDMETVLKVEE--GEWEEVLGDEG--VEEPSLP----APEEQEAEDTLEKLLMQLQSGGIIHEQTGRALLLDEAVASGVVSGHTAVKLMERMKMFSGFFDSQVCESLTTEDVIEEGLMDEKLL-QKVLASDKAISGVLDPGNNFVYSIKDAAAVGLLDKETAMRILEGQVVTGGIVDLKRGKKVSVTLASNLGLIEPTGRTELVKLEKASKGKGSDEVTRQKLINLQAETSGIADLETKRPLTVAESVEKGLLEKEEAFQLLTKQVADGGIIHHVSGMRLSVDSAMKHGLINPDLCKELRKAESVVRQDFVHPATKEKLPLPQAVSLGLLSSEFQRKVQEIQAESGSILDPASGQRLALSQAVQEGLVV----EKALASPEMREGIVDPETCMVVPYSEFLKKCKIDIESGQRYLEVHPFQAIRDEVTGTKLPCAEAVRLGKVDPLPALRLLQAQADSGGVVEGSVSQRLSLRAAVEQGMLDEPMAKVIAT-----NQLRAGGIVDALGGKRLTVKEAVGKGLISQKLAAGLQDVEIPD---------EEVG-SEVCKVGKRQLSQEKVEKLSPKEE--------G--VTP-E------HPSVLGTASLPEGAESRGEVDGETEKIERLGLEKEQRRDDQCGPGD--SSSSVGICHRAAFQETAL--SQKSLQK-------SSSFLLWVPEPKPESSIETAAGLARDTAK---HKGGKGKKT-IPGKDTETPREDQGFPVPPEHGE-TQEERSGIRLRAGSILIQCRQRR--------------------GGGGQCQPEAVPEGSWLISQKL----AAGL--RDLEIPDEEVG----------SEVCKVGKRQLSQEKVEKLSPKEEGV--IFPARSARSDGAEPKAQPEPWWKKGSQKAAPNCSWAQRLTSVVQE-TPAAL----RESVTVGPGKGGMGPAESGEPPEVDVPVGDELGGKKAVKHTERETSPTEG-PIDQEKTSET---ELKPT---QKKKSKKKKAKQGSIPGDSTQPEKPAEKQLLPSLGGKGKKTIPG-KD-TETPREDQGFPVPPEHGETQEVVKGGIKDGHDSLVA--LS-L-EERMAQDDTRVETTWDVS-STATMA--QELPSDLIITEEPTEVQETSAKQH-------------EQRAELRA-DQAPAPPKS-----------------Q--------------EEPPQERSKQPGP---------GD------RGLLLPVIVEGELLET-SREST---RPAQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA----EQNLAALHDLRQQAEALGAELQELSFSVNQELDAVQRIVANPPEEVPEQLLKALEKDAKNLQKSLGSASEVLQSRLQNLRGAA-EAEKAKILAHHEALQGRLQELLSWVSGTAASLGDGDLQPA--T-DASSLSHCLQHYEELKEPLAATKAELDATAFDIQFLISEHAQDLTPQQSRQLLRLLNELQKAFRDLSERVTARLEVLQVCLQQVEQTEQVK-TLQEQQAARARSLAELSRWLGQAEDTLAEQQ-RAE--GDLPALQQRQSDVKVTQGFQVIITAS-LTLPKGGPLMGEDCQSHPSPFGVGALEARLRFSTASLY-LPESHKGSLLNMQELGHSYLEPLCFQVKAAKELEENSNKIDSLLDWVASLE----------E--KGALPEYRPHPVHQGTGTP--AGKSTGDVPDGHAVGADSAAESLDEHYERLKAQHQELLSQQQDVILAWQAAQAFLDKQG---PGEERERLRARLAELRERYPASLARAEAPLK-AQLLREELHKFLRDHGEFEACLEQAEQDLQGMCKGDSD-PASLRQLLRRQGSFSEDVISH-G-DLRFVNMSGRKFLD--GDAGDAESHLL---MSRRVVKSKLEDATQRYTTLHSKCSKLGSHLNTLLDHYQQFQEVAESLRMWLQESEAALGKLLSETVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQE-TTDAIVSRFQSLSQQMSERSDLLQKSIAQSQSVQESLESLLQSVAEVEKNLEKDQPAVLSSASIQDSLATSVKLKQDIARQRSCLEATREMVTRFTEAADSPA-ASALQDKLAQVTEHFGRLCQQQQEREDTLKGLLPTVEQYEQLWERLQQFTESRTRMLASGNQPDRGIAHFSQHIQELNSELRQHQEDLATLEHLAEELSSCGFAPGAFQQQEKLQSLKKDFLQLQKVAKDREKDASSCQEQ-------LDEFRDLVGAVRKWLRESEGKIPPAETSLGTQELQQHRQQI------QD-----LLEEWKGKGPQVEEIGRRGTLLENLIVEITAPSTPPKAGATL---PTPGGSGGSVNGYHTCK-DLTEIQCDVSEVRRRYQALGAALRERQQQLSAMLDRMQEVQEEASSMLKWLESKERMLSELEASSSPTKTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYPDSPEAANWKKMQEDLNCRWERASQATAARQQKLEESASQLATFQATEAQLRPWLMEKELMMSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSTSQVRDELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAISTQPDAVKQQLEETSEIRSDLEQLEEEISEAQNLCDDLSVLIGEQYLKDELRKRLETVALPLKGLEDL------AADRMNRLQTALASSQQFQHMFDELRTWLDDKRCQQAQSQPISAKLERLQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELSKQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADILTDASQTDEDDIRDEKASINQKMDAITEELQTKTGSIEEMSQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQTLEPQVEYLKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKVNDCCALMENKLEGIGQFNSRVREMFSQLADLDDELDSMGPIGRDSDSLQSQAEDVRAFLGKLQRLKSDIESSESECRKMLEDEGSPDLLGLKRELETLNKQCSKLTERGRSRQEQVETTLSRVEDFYSRLKELSRMTAAAEEHEALQWVVGTEVETINQQLADFKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_11 (2099, 2139)

LL
IRQLQTGGIMDSVTGERLTVDEALRKGLVAPRIALLVL

ENSGT00760000119163_1_Linker_11_12 (2139, 2146)

ESLGSFV

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2177)

GLLWPETGEIIPVAD
ALEQGILSTELIQEVL

ENSGT00760000119163_1_Linker_12_13 (2177, 2647)

SKRQLLQAVLTPDTTEVMSWQEAVERGVLEREVVKKLKSMAIPD
VMASVQLAGSPSRSRHSHSSPGRSP---TG---QE-----EPLLRSDDEK-LMFHLMTHS
YINIHDGQKVLLVDAELNNLTK--TLIQSQ-ENGS---CFE---------ETQADR--AL
ESEPC-----NGVALQQLELQFAPSKGESEKILSPRTALENGEVVVGPESLL-------L
EDAEDFLRVEEQEQISTEQEITR-SEADAEF------------GKEHITFTAK-----DK
HQVKLLMP-EPPSDLDSGLIRETEEVMVEAEEESKPP--AVDGVEGPEHQK--KELESGA
VVVKSEISITMGVPESRDSLKIMAE-RSQGVREPEREAEDVREVYLPKEGTAENGVL---
----EGEE--RQSTDMETVLKVEE--GEWEEVLGDEG--VEEPSLP----APEEQEAEDT
LEKLLM

PF00681 // ENSGT00760000119163_1_Domain_13 (2647, 2683)

QLQSGGIIHEQTGRALLLDEAVASGVVSGHTAVKLMERMKMFSGFFDSQVCESL
TTEDVIEEGLMDEKLL-QKVLASDKAISGVLDPGNNFVYSIKDAAAVGLLDKETA

PF00681 // ENSGT00760000119163_1_Domain_15 (2756, 2793)

MRILE
GQVVTGGIVDLKRGKKVSVTLASNLGLIEPTGRTELVKLEKASKGKGSDEVTRQKLINLQ
AETSGIADLETKRPLTVAESVEKGLLEKEEAFQ

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2896)

LLTKQVADGGIIHHVSGMRLSVDSAMK
HGLINPDLCKELRKAESVVRQDFVHPATKEKLPLPQAVSLGLLSSEFQRKVQEIQAESGS
ILDPASGQRLALSQAVQEGLVV----EKALASPEMREGIVDPETCMVVPYSEFLKKCKID
IESGQRYLEVHPFQAIRDEVTGTKLPCAEAVRLGKVDPLPA

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3082)

LRLLQAQADSGGVVEGSVS
QRLSLRAAVEQGMLDEPMAKVIAT-----NQLRAGGIVDALGGKRLTVKEAVGKGLISQK
LAAGLQDVEIPD---------EEVG-SEVCKVGKRQLSQEKVEKLSPKEE--------G-
-VTP-E------HPSVLGTASLPEGAESRGEVDGETEKIERLGLEKEQRRDDQCGPGD--
SSSSVGICHRAAFQETAL--SQKSLQK-------SSSFLLWVPEPKPESSIETAAGLARD
TAK---HKGGKGKKT-IPGKDTETPREDQGFPVPPEHGE-TQEERSGIRLRAGSILIQCR
QRR--------------------GGGGQCQPEAVPEGSWLISQKL----AAGL--RDLEI
PDEEVG----------SEVCKVGKRQLSQEKVEKLSPKEEGV--IFPARSARSDGAEPKA
QPEPWWKKGSQKAAPNCSWAQRLTSVVQE-TPAAL----RESVTVGPGKGGMGPAESGEP
PEVDVPVGDELGGKKAVKHTERETSPTEG-PIDQEKTSET---ELKPT---QKKKSKKKK
AKQGSIPGDSTQPEKPAEKQLLPSLGGKGKKTIPG-KD-TETPREDQGFPVPPEHGETQE
VVKGGIKDGHDSLVA--LS-L-EERMAQDDTRVETTWDVS-STATMA--QELPSDLIITE
EPTEVQETSAKQH-------------EQRAELRA-DQAPAPPKS----------------
-Q--------------EEPPQERSKQPGP---------GD------RGLLLPVIVEGELL
ET-SREST---RPAQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA--
--EQNLAALHDLRQQAEALGAELQELSFSVNQELDAVQRIVANPPEEVPEQLLKALEKDA
KNLQKSLGSASEVLQSRLQNLRGAA-EAEKAKILAHHEALQGRLQELLSWVSGTAASLGD
GDLQPA--T-DASSLSHCLQHYEELKEPLAATKAELDATAFDIQFLISEHAQDLTPQQSR
QLLRLLNELQKAFRDLSERVTARLEVLQVCLQQVEQTEQVK-TLQEQQAARARSLAELSR
WLGQAEDTLAEQQ-RAE--GDLPALQQRQSDVKVTQGFQVIITAS-LTLPKGGPLMGEDC
QSHPSPFGVGALEARLRFSTASLY-LPESHKGSLLNMQELGHSYLEPLCFQVKAAKELEE
NSNKIDSLLDWVASLE----------E--KGALPEYRPHPVHQGTGTP--AGKSTGDVPD
GHAVGADSAAESLDEHYERLKAQHQELLSQQQDVILAWQAAQAFLDKQG---PGEERERL
RARLAELRERYPASLARAEAPLK-AQLLREELHKFLRDHGEFEACLEQAEQDLQGMCKGD
SD-PASLRQLLRRQGSFSEDVISH-G-DLRFVNMSGRKFLD--GDAGDAESHLL---MSR
RVVKSKLEDATQRYTTLHSKCSKLGSHLNTLLD

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

HYQQFQEVAESLRMWLQESEAALGKLL
SETVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQ
E-TTDAIVSRFQSLSQQMSERSDLLQKSIAQSQSVQESLESLLQSVAEVEKNLEKDQPAV
LSSASIQDSLATSVKLKQDIARQRSCLEATREMVTRFTEAADSPA-ASALQDKLAQVTEH
FGRLCQQQQEREDTLKGLLPTVEQYEQLWERLQQFTESRTRMLASGNQPDRGIAHFSQHI
QELNSELRQHQEDLATLEHLAEELSSCGFAPGAFQQQEKLQSLKKDFLQLQKVAKDREKD
ASSCQEQ-------LDEFRDLVGAVRKWLRESEGKIPPAETSLGTQELQQHRQQI-----
-QD-----LLEEWKGKGPQVEEIGRRGTLLENLIVEITAPSTPPKAGATL---PTPGGSG
GSVNGYHTCK-DLTEIQCDVSEVRRRYQALGAALRERQQQLSAMLD

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMQEVQEEASSMLK
WLESKERMLSELEASSSPTKTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYP
DSPEAANWKKMQEDLNCRWERASQATAARQQKLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5140)

ESASQ

PF00435 // ENSGT00760000119163_1_Domain_29 (5140, 5244)

LATFQATEAQLRPWLMEKELM
MSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSTSQVR
DELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAIST
QPDAVKQQLEETSEIRSDLEQLEEEISEAQNLCDDLSVLIGEQYLKDELRKRLETVALPL
KGLEDL------AADRMNRLQTALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

SQQFQHMFDELRTWLDDKRCQQAQSQPISAKLER
LQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELS
KQAADRHSKL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCLQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5578)

KAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAM
LSDVEKRRSLLEMLNSAADILTDASQTDEDDIRDEKASINQKMDAITEELQTKTGSIEEM
SQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQTLEPQVEY
LKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKVNDCCALMENKLEGIGQFNSRV
REMFSQLADLDDELDSMGPIGRDSDSLQSQAEDVRAFLGKLQRLKSDIESSESECRKMLE
DEGSPDLLGLKRELETLNKQCSKLTERGRSRQEQVETTLSRVEDFYSRLKELSRMTAAAE
EHEALQWVVGTEVETINQQLADFKV-----------------------------------
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-----

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----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 458)

QISDIYISGESGDMSAKEKLLLWTQKVTAGY

PF11971 // ENSGT00760000119163_1_Domain_2 (458, 510)

TGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEAWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKATHS--------------SSASWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLMSWNYLRKDLDLVQTWNLEKLRSSAP
GECHQIMKNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKAHFQHLMKSMENE
DKEETAAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDKDARQDNALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEAVLADLSALEAHRSTLRHWLSDVKDKNSVFSVLDE
EIAKAKAVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-ETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLHALNKA
YHDLCDGSANQLQQLQSQLAHQTE------------------------------------
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---------------------------------------QK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSEAS--LEKGALDTTD
GY-MGVNQAPEKLDKQREMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML
QEKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGD
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVEKLL
SDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FKQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITRFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVHKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQLQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELQVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6126)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6802)

DAMQA

PF00435 // ENSGT00760000119163_1_Domain_44 (6802, 6910)

AVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMENQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7466)

QALKQ

PF00435 // ENSGT00760000119163_1_Domain_50 (7466, 7578)

AEV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLNQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7944)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA
-----------------------RGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTK--------------------------
-----------VIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTVAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

MGNSLGCVKEPKDSRAIPEKAPISPKKRVRFKRKWRGKKTPTPEVSHEEEPLEGTTVIEE
TETLPKLTVSLQKEEGAGGTEHPPSDILLPRDSA-PSPGMGAQGMIVQVKERFQGEIQTA
HLLLENESSVAGGVWDSLQEGRTVIAHLLDNPAERNCEKSVSQLVEFPRTASCNSRAVLL
PLQGETAVGKGGAQLGLRSGTLPPPDHPTDAGSPDQLSGVQGVGAGTSG-----------
I------------------------CSGPQTGAWIAEPSVPSSLPDQSRGHRCTEPAHVG
RVPPQGPRLPTSQSDLSISGRTVSVLPSSSGYGS--------------------------
-------------DGPHLRGIQPRDTE-----------PEKSSTSFSEEDGTLSLEASHT
PPWGLEEISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELAPPST-------LTTTHLKAEPLTKGTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTMQLEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSMVGDEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEGRTVLPE---SDGPLASATC--------------------
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---------PRE

PF00307 // ENSGT00760000119163_1_Domain_1 (373, 427)

KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_1_2 (427, 441)

QISDIYVSGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNAIIH
RYRPDLVDMQKVELQGNRENLEQAFEIAESLGVTRLLDSEDVDVASPDEKSVITYVSSIY
DAF

ENSGT00760000119163_1_Linker_2_4 (544, 949)

PKVPEGAEGISATEVDSRWLEYQERVVCLTQWIRQHVLLMSDKSFPQNPVELKALY-
NQYVHVKETEIPAKEQEKEQIQKLYQMLQAWIEFGRIKLPPSFHPNDVEEQWGKLILSML
EREKILRPAVERLELLLQIANRIQNGCLSCEEKLTLARNTLQSDAANIECGQTFQQESEV
VQFLQESEVLLRQLQSDVQILRDEKYFQVEELAFRVLRIQDELLNLKMECTNLYRRGNLI
TSDLQPTVS-------LSNTHQHSLH----TSP--------------SSSSWFRKPMSRT
ELVVLSSSEDEGSLRFVYELLAWVEEMQMKLEISEWGSDLPSVEAQLESQRIVHTSVEEL
TSSLREARSYEVKMSHNFRS-SYSETLSKLETQYCKLRETSSSRLHNL

PF00435 // ENSGT00760000119163_1_Domain_4 (949, 1059)

QSLHDFVSQATA
QIIWLNQKEEEELAYDWSDGNPNIAAKKEYFTELMQELEEKQ-DVIQALQETAEL-----
LSLENHPAKQTVEAYSAAVVSQWQWVKQLCLCVEQHLKENTAYFQFFNDVRESEVYLNNL
QDSIKRKYSCDRTTSINRLEDILQDSM--DEKEQLIQSRSSVASLVGRSKNIVQLKPRNP
ELTLANTLPIKAVCDYRQIEITIGRNEECVLEDNTQRTKWKVISTTGNEAMVPSVCFLIP
PPNQEAMEMASRVEQLYQKVMSLWHQLHINTKSLISWNYLRKDVEVVQSWNAEKLKVLPL
AERLETLSNLSASLKCHLDEFLEDSKDSQIFSMTDRLNMEQEVESCRDQCRQLVDMIVTE
DKEESEARTYLSELYNIELQMGHCEQRLVKRIQSPVG--TDADAVHEITIYISEQERMQE
ELNRLKSELSVVSERCDDFVHKSPSGSCTPNLRSQLDLLVGKMDQIYGLSSVFLEKLKTV
DVVIRSLQEAEGMVKGFEIKLSQEASLNADTSFIQSQQDLLQQWLTEAADKDSIISALEN
DIAKSKDVRERLYKMTQERSMDVEHYQERADKLRERWNAVH-SQLETRESELLGIQESLR
NYRGLHDNLIHWIEETKSQQEMMKPGQSEDRRVLSEQLSQQTALVAEIEKNQTRLDKCQT
ISQQYSNLVKEYELQLMTYRACVESQQKSPMKRRRLFSSSDIITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKSFTHQPVKVYGKRIPIPRF---------HGLTAT-TLTNG
QRPLFSLFVTQALSEELLSQKEHISEAVKSMQIFLAKNSDRLSAQEKEELLSQIQELNGK
YSHLSEECDNQVQQLHTKLAQEAEQKVDHA--VGGVIDLGS--MEIFPIFWAIQRGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LLLLEAQIVLSGLIVPATNERLNLKEALKHNIIDQRLFQFLKDL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

RDASKVVAG-AGS
KSGKQKLLSVIAAMEDKKIRESDG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1992)

LKILSIHFATGGFRLTAEEDVTNLERAAEAGLISRR
LCQKLKS---S

ENSGT00760000119163_1_Linker_8_9 (1992, 2021)

SKSLVDPNTAKRMSLAEIMQTCIIHESTG

PF00681 // ENSGT00760000119163_1_Domain_9 (2021, 2058)

LRLLPVKQLSVGMVCLKSGK
KVSIFSAVQEGLIDRQV

ENSGT00760000119163_1_Linker_9_10 (2058, 2059)

A

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIKDTKTGHRLTVEEALRQQLMDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

IALL
KRQLEDGGIIDTATGQIITLGEAVKQNIVSPKLALLVLESLGSFKGVLIPESGEILLVAD
ALQLGIISTEFAINALGSRQRIQGLYMLEDRRILSWDDTVKCIIMDENIAKILQSIDIPD
TISSLEAGSASM-PELGLCPGTLSVNSSPCPLESSELEMQRG-ACSEGNRELISHLMNVS
YINIHSGKRLLLTNKN-ENIVT----------------KLFPGAFLDNSIVVSHNN--KE
EIHMQHT-VEKKLESMALLANFTAKNTEAV-----TNLEK-------NQCL--------L
PREGRLPLDTHHAKLDETLSSLQ-NNHASQLQLAAHCGDVEEKMFKHPEISSF-----ST
EQLLLPAV-PENSANEINDSKTEISPVNKGLVDIQVQTLSVNGKLPEITAQ--S------
KTNKAFEMS---FDPDKVTNKSDLKTENVDVLNYIPEQQVASSKCLTVNAAYPEKIF---
----CKGK--LEDSGGLLDNM-HDHYDISSSEQVDNYA------------HVME--EEDA

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2685)

LNMLSEQLTNGGIVVPNSSQKLLLNEAANHGIISSHTALKLMERVGLFAGFFDSQTCERL
TIQDVSQISQVPESDI--------RINDGVLMEQTQRNITXTDDFKVHCKPSAAETSV--
PSFFGEGLLDVNH---FDTNMCVDETSLHVTSTKVYSDSQLSESKSTDGETSKLPCISLN
LDKQELSPEVNCGPIFKNQEVKR-------------------------------------
-----------------------LLPDTALFSPVPEK-----------------EHFTDR
LVNKHSEKITTITENVSKDLQK----LQNDKQQGQ------------IP----ISQCDLP
MVSDQK-----PFTTSN-YVPSENLPFSQDLSQSDMSSVSRIF--------------QKS
GNIEFYSEVDMMYFDSQKY----------VKKYNDKIQQKLSEKELVIEH----------
------------EQQR-EGSCLTQD-LYLCALNKSSVQSVI------NIQQEC--ELIQT
SGDL-TVGKPNKNTVKQPKYLTDA-------EPKVNTDNPAKE-----------------
-NSEKVTVKPEKDLTAGT--IKEGTRKPI--KDIKSKQIKEDVVNPATNFKT----EIPT
EHTV---------------------KPSNGVISK-EDTV-TSVRAL------TDVRFKQD
AIKPTRQ--LALV-KSKEGTFKPSR----KPKED-PVKVDQSLMEGNSKDETVNESNDRK
EGPPKKKAE-ARPIEDTIE---------PGRDFALEKPKVSTTDI---------------
------------------DYSHQNIIL-------------------S-SIVILHKKLGF-
--------------------------------------------------------SRDK
N-AG-ITLNSFPL-------------------LKV-KN-LYLLYTDKCKSCGFSIEHNHC
VLQNQSSLDSYTISIKQTC-L--EHEENLVSYLSMLR----DIEVRL--GPVQPIPPSI-
KEVEEQLKQAEVK--DS---------TLNFVWCY-LSTQHFTLKHFNL-RCKTMHSVNTK
GT--------------AVSFSLVQLLSGN---------TQ------ASGGGGGVREFTHA
C--SCGGFYDQRGWPRGAR--------KDKC---NGKLYCIIQKEKKKGIRIIMVDPV--
--ITIRASRSSVV---QVLDLELRQLMSPVSQELDFAKRIISDQPTEVPVQLLRALEKDA
KNLEKSLTSIKGNSELRVKQLQDAL-KTEKGKILVEHKELESKLHYLLQWVKETTDSLDS
AKTNDDLRL-DAEKLQKELNHAESLRRPLTDTRQKLDNIAFDIQFFISEKAQDLTPQQSR
TLLRLLNELQRSFRELSERLVAWEEVLQLYEKVLQNIGFLQ-ILQEQQATCSKEFEELAS
WAEHTEKALPSLQ-TFHKTTDLSSLMEQQKAVQVLHKDVQSRGKHFSRVIRAAEDFLAEN
KLKMDPVELESFQKKLQQAKERYHAVLEKTGDTEKQLESAVSTAVLEETKKISTFLYLGK
NKDNKKDEDIWILGSEINLETWIKQSE--TAEELKVNLGKIESLLSQV----RPSYALLK
TV-PDGNETSFMVNELYERKKTQHQEMLEQQQNFILTIQSAQDFLDKHGNTLCPEERQQL
QNQLAQLKEEYSASMSQAQLQLKNAQVLRDEMQNFIRDHGEFEHWLIHTEEELDNMHKGK
KD-YNALKNLLNQQMNISEDIISHKG-DLRYINLAGQKAIEA-EKATADQCKEDFEMVAG
AMVKNKLEEASKRYSTLQSKCSKLGCHLNVVLDRYQQFQEGSDTAVAWLQVTELEVDCIL
SEPVASDPEVLQNQLAKA-K--GMQSNFAEHQVQVEKVHKALRMLLEIQDDPIPDCRSVQ
DIAADSIDRRFQNLSNQMSSHSDLLQKTV

PF00435 // ENSGT00760000119163_1_Domain_26 (4650, 4757)

AQSQSVQDALENLLQWLKEMEKTLAEQKHTR
MSSASVEEALAVNMKLKQDISSRRGSMDATGEMVGKFMETADSAA-ASALHSKLSEVTSR
FNEVCMQQRLQENALKEILPKVEKYEQFSNELQDFTVTRSHLLASGNQPERDITQFSEQI
KELNAEIKQQEGHLLMVEQLARELSASPILTDASEHLQKLATLKKDFAELREAALARESE
TLSCQES-------LEQFQKLVGVMRKWLKEKEDIVPSAEDSLKTCEMMSRLQQV-----
-KD-----LLSEWEMKSPKMAEIAQKGSELECCIMEITAPACQRKGGSLL---MATGSSL
GNVNGYHTCQ-DLTGIQCDVSETSQKFENLGLLLHKREEQLSKML

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

ENFEKIKQETNHMLK
WLESKEKTMTAVNV--SPTKSEVVKAQAKQNKEFLSELEQSTEKVESLKAALRDLLEKHP
NSPEAENWKTMLENLDQQWGRVNQVTAERQHKLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5138)

ESA

PF00435 // ENSGT00760000119163_1_Domain_29 (5138, 5246)

NQLATFQVAGSQLCPWLKEKELM
MSVLGPLSVDPNMLNAQKQQVQFMLKEFEARKAQYEELKLAAYGILTGPGEESPSTCQVE
EEFHNISGKWMELTSRLNSRADQID

ENSGT00760000119163_1_Linker_29_30 (5246, 5249)

QAT

PF00435 // ENSGT00760000119163_1_Domain_30 (5249, 5362)

IKSSQYKEVLQRLTDKIKQAGKNLAAQPAVST
QPDAVKQQLQETSGIRSELEQLAKEVTDAQKLCNELSALVMEPYLKDELQKRLDTVALPL
KGMEDL------AVDRVNRLQ

ENSGT00760000119163_1_Linker_30_31 (5362, 5365)

TAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

SSSQQFQQMFDELRSWLDEKQLQHVKSHPVSAKLEK
LQIQLQEQEEFQKSLSQYSGSYEMIVAEGESLLMSAQPGEEKTTLQNQLVNLKSNWNELG
KQSSERHGKLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYVRHVEDMVPWLEDCEIHMKEMEITLDPVQLEAQLLRAKAL
QTDIDKKRSLLEMMNSAADLLIEAAEIDDRDILEERAKINQRIDAITEELHNKSGSFEEM
SLRLKELKDSFSNIDKKMEGAKHLLEIFTALGPQACSSKNLESMRSQQDMLLGLDSQILY
LKNLIQGLIADVPQDSDVSHLVYQAQQVQHDFEIVKEDVNECCANMETKLQGIGQFHSHV
REMFSELADLDDELDSMGPVGRDIDSLKSQAEVIQKFLEALLSLKSSIESSECKCRDMLE
KEGGPDLIVLMRELGTLNKQCSKLTERGKNRQGQLVATL

PF00435 // ENSGT00760000119163_1_Domain_34 (5800, 5908)

RRVEEFNMKLKELNHQIVTAE
GSSVLQGVVGTEVDTIKQQLDNFKVFQKEQVDSLQAKLHQVNGIGQGLIQSADKNCDVHG
LEHDTEELNIKWNTLNKKVAERVTQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5911)

EAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLTDTEDLIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRRTTVEMIQAEGVRIAEGADPADGDKISHQLEILA
ERWSLLLQKAQSRQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6022)

DIL

PF00435 // ENSGT00760000119163_1_Domain_36 (6022, 6237)

VLAKQFHETTEPIFDWLSATEKKLANSEPIGTQTGKIQQ
QIQRHKAL----------------------------------------------------
---------------------------------------------------------NED
IINRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYSEITASSGKALKTLE

ENSGT00760000119163_1_Linker_36_38 (6237, 6240)

QAL

PF00435 // ENSGT00760000119163_1_Domain_38 (6240, 6346)

Q
LAGKFQATHDELTGWLRRAEDELSQSFGQSPSGDMIPQFQQQQKELKKEAMEYRIVLDTI
NEVGSALLELVPWRAREGLDKLVADANEQYRSISDTIGQRVDQID

ENSGT00760000119163_1_Linker_38_39 (6346, 6349)

AAI

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

QRSQQYEQAADA
ELAWVAETKRKLLALGSICLEQ-DQTTAQLQVQKAFSVDIIRHKDSIDELISTEEEILAT
CGDEQKSVLQEKTKNLVQHYEDISHLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVGQFWETYEELIPWIDEMQV
LFSQLPPPAVDHEMLRQQQE-EMRQLRESVAEHKPHIDKLLKIGPHLSELNPEEGTAVQE
KYRSAEKLYVGIKEEVRKRAMVLD

ENSGT00760000119163_1_Linker_40_41 (6565, 6568)

DAL

PF00435 // ENSGT00760000119163_1_Domain_41 (6568, 6688)

AQAA---Q-------FHDKIGPMLETLESMASR
LRMPPLIPAEVEKIRECISENKNAVMELEKLQPAFQALKHRGEELISRSQGPDIDPAAKD
IQDKLDQLVFFWEDIKARADERESKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWLDMNTLLTTIKDTHEIVHDLESP
GIDPSMIKQQIEAADSIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNTA
WENLKRTWAERIEKLR

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

SHAVQYQD----SLQAMFDWLDNTVIKLCDMPPVGTDISTV
KEQIEEMKEFKVEVYQQQIEMEKLNHQGELMLKKAIDDTDRDIIQGPLTELKHLWENLGE
KIAHRQQKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

DSL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALAELMSWLTHTNELLNAQRPICGDPKVIEVELAKHHVL
KNDVLAHQSTVQIVNKAGNELLESSAG-DDASSLRTRLETLNQLWEIVLQKTEEREQQLD

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

MALQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFSGEIEDFIQWQTNIESQLSAAKPTGGLPETAREQLQAHMELFAEIKANED
LYRHLLDKGQLMLISRDD-ATGSITEQNVSILKRKWQAISNKVEERKAKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

TLATDF
QNSLQDFINWLTQAEQSLNIAPSPSLILDTVLFQIDEHKVFVNEVNIHREHIIELDKIGN
QLKFLSQKQDVVLIKNLLLSVQSRWEKVVQRSVERGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EEAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGSKQPVYDTTVRTGRALKEKALLS
GDVQKLDHLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPLHGDLDLVMNLMDAHKVFQKELGKRTSSVQALKRSARELLESSREDTTWVKVQLQE
LSTRWDTVCKLSVSKQTRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FHAAVHMLLEWLSEAEQTLRFRGAL
PDDAESLQSLIDIHKEFMRKVEEKQIDVNTAVSMGEEILTMCHPDCITTIKHWITIIRAR
FEEV--LTWGNQHQQRLQ

ENSGT00760000119163_1_Linker_50_51 (7579, 7582)

TAL

PF00435 // ENSGT00760000119163_1_Domain_51 (7582, 7720)

SELLANSELLDELLSWIQWAE-TTLIQRDQDPMPQNIDQ
VKALISEHQVFMEEMTQKQPDVDRVTKTYKRKTTDTNHASFNDKTRR------KHSVQNA
TPVLPVLSQPETKNPRINQLSARWQQVWLLALERQRKLN

ENSGT00760000119163_1_Linker_51_53 (7720, 7763)

DALDRLEE----------LKE
FANFDFDIWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTRL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7922)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGNKLKRTDSISSIASRLPTI--STSLKTSRSSLTGDTPTSSSAKSGRAGKRPIAARD
LDRQKGAGPPFRT-SAFSHTSVSAYCFAPSGAH---------------------------
----------SAQGQNAHGEKRFSQGPCHSQAEPPGRQELVIAAVAAWDREVFEGI----
----------------------------------------NSDPKKSASRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGPGSSRRGL--SKPSKIPTMSKKTAS-TPKT
QGTKR

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------IPIIVIEQTTRPISSVG----
MSPGPQMSFVC-------FADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKATH---------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLEAQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKKNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMRQLCLCVEQHVKENAAYFQFFSDARDLESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLIQTWNLEKLRSLAP
GECHQTMKNLQA----HYEDFLQDSRDSALFSVADRLRLEEEVEACKTHFQHLMKSMENE
DKEETAAKIYISELKNIRLRLEECEQRLVKRIQSPASSRTDRDARQDIALRIAEQEHTQE
DLQQLRSDLDAVSLKCNSFLHQSPSGSSVPTLRSELNLLVEKMDHVHSLSTIYLNKLKTI
DVIVRSIQDAELLVKGFEIKLSQEEAVPADLVALESHRSTLRHWLNDVKDKNSVFSVLDE
EITKAKGVAEQLSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLETRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTNLFAEIERNQIKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKDLLGWVSTLAKNTQEKITSS-HTKES
TDIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKEQISEQLDALNKA
YHDLCDGSSSQLQQLQSQLAQQTEQKDCRT--VAGVIDLGT--MEIFPIFRAMQKGLIDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1904)

VLLEFQVIMFGLVAPETSEKLSLEEGLARNLINPQMYQQLRELKDAISLISR-LTE
SKG---SLSVMEAIEKRIISERVGLKILEAHLATGGFSVSPSENCINLEEAFHQGFISTW
LHSVLESHLRSSKNLIDPNTAEKISLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSGR
KVSVFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2098)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMAC

ENSGT00760000119163_1_Linker_10_11 (2098, 2103)

AIF
IR

PF00681 // ENSGT00760000119163_1_Domain_11 (2103, 2138)

QLQTGGIINTVTGHRMTIDEALTNDMVSAKIALVILESLWSFMGFLWPESGEILPITD
ALKQGIVSTELAHKILSNRQHIKALFLPATTEIWSWKKVIENGVLDKDLANNLKSICIPD
VMPHMQLVDSSEQNKLSTTPGAAPP---PCSKSQS-----GD-IASHDEK-LLFQLMTHS
YINVQNGQRLLLLDQELLETLS--SIDEHK-ISPS---EVFGVGDQKVDTPEELQE--SA
NGNITET-FSDGLTLRPCEFQFSSQNEEYPNQEDYTEAKGRKTIVGGKCSS--------I
ENSEKDLFV-EQKIINANIDTLK-VTKKVNLELQRQLFVPPKE-----------------
---VEGGP-LEIDRNLS---------FETPAEEWRTP--RNIFFLCQREQA--KALKTKY
TPSETGRPL---LRSQSKNSQVQSE-KSLGFKSELKWEDDMNIHSLEKEKVLNKSLL---
----TKGD--HKQSQEGHSIA-DNKMMMLEKTDTQDSGRAISLSCS----SPSELLEEAT
LN

PF00681 // ENSGT00760000119163_1_Domain_13 (2643, 2681)

ILSAQLLDGGILHEETGQKLLLNEAIAQGIVSSHTAVKLMGKLNMFRGFFDSQTCESL
TTEEVINEGLMDEKLL-HNVLMADKVISGVLDPRTHTLCSVKDAVTTGILDKETAT

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2790)

RILE
GQVVTGGIVDLKRGKKVSVTLASNLDLVDSADQTELINLEKASKGREAEKLVREKLIGLQ
METIGLMDPNNKAPLTVVQSIDQGLLKKEEAIC

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2892)

LLTKQVVDGGIIHHTSGMRLSVDNAFK
QGLIDEDLTKQLKKVENLNLHHFFHPETKESVSLHEAIKLNLTTPDLKREIQESQAFSEN
LVDLISGQRLTVAEANKGGLLT----NKAVLSSVMMHGVVDPENYRIVPYSELIKKCKID
IESGQRYLEVIPFSDIKDGVSDKVIPLSEAVQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3081)

VLEAQANTGGIIDTATG
ERLTLALAMEQKLMDKNMARIIAS-----NQMLNGGIVDIFNDKRVTLKEAVEKRFISPE
LATLIQIDTFKSTHME-K-----QNQIEVCELQTEYLRKKILISYNQTAKMSC--DKGES
KSAL-QIESQFARGEDKVRDSDGK-------QIKESKEISLEQLEDKDHDKWGASAD---
AKGSASVLSPSNLKGKSL--DQVSVPHPH--SAVSDFRLKEVARNNLGENTN----EEHK
KGVTHIETVTHLKQP-NSGLDKAEAKENQREMIW-EVQE-SNCKAS------DRLLSEQP
L--NIRV--TSE--REKREMIVEESVRPCRPAVLSEEKLDQEMTRSERE-----------
------KES-DRETGFSVTCKTEDSSS-QVTPKGISVKNQDTLTFF----I----SEEEV
K-----------NVNLCLTLKPGEILHQELTSGAQS-HPFSFMTPRP-EGFHCQVSVIKA
QVTDTPQISN-TNRTTQGASSQETNYYQD-SCVTSKTTETK--DLIFP---S-KE-CKET
S-YQEVPFVSRKV-------------------LKF-EE-IIVSKVDPEEVSYLKSSDRKD
LHHQNSKGDREHCGTLKSK-M-ATTQETNGEKFLEMTNPI-FTDPEA--GSPEGILIQGG
PTVLVTLLPEKLP--KEVS----QKENTGQQDSV-ISSTTLETSEETT-LSLPSCSTVKV
D---------------MIPQEKLREGLGS---------KP------TPFTDMLRGKGSDG
V--NPEPL---RATQNVFN--------RQLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNLVELQDLLCQAKVLDEELKDLSALVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWSSRLLHLQNAM-EMKKASVLNQHMQLEGKLRGLRAWVGNTSLILNS
KRYDSE--T-DIDSLNHSLQEYEDLKQLMVERKSQLDDLAFDIQFFISEHAQDLSSQQNR
QMLRLLNELQRSFQDLMEQTTVQTNALQGHLHQMQQETWVK-TLQKQQSTCHQKLEDLCS
WVKQAERALLSHQ-GSASWQDLSTLQKNQRDLKDLQDDIQNHATSFTTVVKDIEGFLEEN
HTKLSPQELTALREKLHQAREQYEALQERTRVAQKELEQAVTSAVQQETEKSKAAKELAE
NRSKIDALLDWMTSVG----------P--SGGQPQTSLSGMEQLSRAG--LEKGALDTTD
GY-MGVNQAPEKLDRQCEKMKAHHQELLSQQQNFILATQSAQAFLNHQGHNLTTEEQQML
QKKLGDLKEQYVASLAQSEAELKQVQTLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGN
IS-PQALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

EEGKEPS---TTR
NLVKEKLKDATERYTVLHSKCIRLGSYLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSIKAWLQTCEASVEKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVAHDLMEIEGEPSLDPKHVQ
E-TTDSILSHFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVEQNLEGEQVAS
PSSGVIQEALANNMKLKQDIARQKSSLEATREMVTQFMETADNIT-AAVLQGKLVEASQH
FEQLQLQQQEKESTLKKLLPQAEMFEQLSNKLQQFMENKSRMLASGNQPDQDIAHFSQQI
QELTLELTDQQENLDTLEHLVTALGSCGFALDLSQHQGRVQNLKKDFAELQKTVQEREKD
ALSCQEQ-------LDEFRKLIRTFQKWLKETEGSIPSAETFMGAKELEKLIEHL-----
-KG-----ILIDWASKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDLSDVNLKYEKLGGVLRERQESLQAVLS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEACSVLQ
WLESKEEVLKAMDASLSPTKTETVKAQAESNKAFLAELEQNSPKVQEVKQALAELLMTYP
NSQEAENWKKIEEELNSRWERATEVTVTRQKQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFETRKQQHEQLNEAAQGILTGPGDVSPSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDNEIKEAQTLCNELSVLIGEQYLKDELKKRLETVTLPL
QGLEDL------AADRMNRLQSALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELKTWLDDKQSQQAKSCPISAKLEQ
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKSHWEELS
KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIENCKAKMSELQVTLDPVQLESSLLRAKAM
LSEVEKRRSLLEILNSAADILINFSETDEDGIRDEKAEINQNMDAITEELQAKTGLLEEM
TQRLKEFQESFKNIERKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPNGSDASQLLHQAEVTQQEFLEVKQRVNSGCMTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQSLKFDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKVLNDATTAAE
EGEALQWIVGTEVDVINQQLADFKMFQKDQVDPLQLKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAEVADREKITGQLGSLE
SRWTELLSKAAARQNQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6235)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHK------------------------------------------------------
-------------------------------------------------------ALEEE
IENHATDVHQAVKIGQS-LSSLTCEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYDELTSWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLISDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETTRKLMALGPVRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKAVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LITQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGKMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALMRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMYDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLA
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPVPQNIDR
VKSLIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPSHGPFIEKSRSGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------IPSAGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSTAGGQGSSRRGL--TKPSKIPTMSKKTSTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------CMYMSQHM
C-------RSED----NLRELALS-LS---------LSTPW---------ISGIKL----
RSSSLHPFCLS-------FADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIRQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEIPAKEREKGRIKELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELAPPST-------LTTTHLKAEPLNKTTHS--------------SSSSWFRKPMTRT
ELVSISSSEDEGSLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHA-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNGKEEEELACDWSDSNPNIAAKKTYFS---VSVTQQD-VMLNSSSKRQR------
---TSPQRHCCSVAYNAAVQSQLQWMKQLCLCVEQHVKENAAYFQFFSDARDLESFLRNL
QDSIKRKYTCDHSTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAS
GECHQVLKNLQV----HYEDFLQDSHDSTVFSVADRLRVEEEVEACKAHFQHLMKSMENE
DKEETVAKVYISELKNIRLRLEECEQRLLKQIQSPASSKSDRDARQDSALRIAEQEHTQE
DLQRLRSDLDAISMKCNIFLQQSPSGSSATTLRSELNLMVEKMDHIYGLSTVYLNKLKTI
DVIVRSIQDAELLVKGYEIKLSQEEAVPADLSALESHRATLQHWLNDVKDKNSVFSVLDK
EITKAKEVAEQLRHPMPEQNLDLERYQEKGSQLQERWHRVI-AQLETRQSEVESIQEVLR
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGTATSS-HTGVP
TDIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKEQISDQLSALNKA
YHDLCDGSANQLQQLQSELAQQTEQKGCRA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1905)

VLLESQVIMSGLIAPENSEKLSLEEGLSRNLINLPMYQQL

ENSGT00760000119163_1_Linker_7_8 (1905, 1947)

LELQDSLSLISR-LTD
TQV---PLSVVEAIEKKIISERLGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1986)

VLEAHLATGGFSLSPSENCINLEEAFQQGFISSQ
LHSVLQSYLRSSKNLIDPNTAEKVGLLELVQRCIIHQESGLKLLPIKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2100)

I

PF00681 // ENSGT00760000119163_1_Domain_11 (2100, 2138)

L
TRQLQTGGIIDTVTGNRMTMDEAVSNNLVAAKTALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSKRQQIEALFLPAITEIWSWKKATESGILDKDLANNLRSVCIPD
VMPHIQLADSAEQSKLGVAPGLPPL---SCQR--------EK-RLSPGEK-LLFQLMTHS
YINAQTGQRLLLLDQELLEMLA--SRNEYQ-TGLP---DVSEIQHHRLDSSEELQE--LD
NGNISQI-SSGKCTRKPCESQFPSQNKDYPNQQNCTEAKGKRIVVGIECSS--------E
QSLQRDLFVGEQKAITANVGTLK-VINKVNLELQSPLLGTRKEEQTEMFSKES-----IS
QGPLLAEC-PEDSEDL----------LSTEKSEWQAP--TKTSFTCQKEQV--TIVRTEY
VPNETGIP----LKSQNKKSQFQVE-TSLRLKSEFKSENGMNINSLEKELNETRLV----
-----KDS--HKQTQDGQSVA-DDHIVVLENIGVEDNGGEPPLLSS----HPFELLEEAT
LST

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIVHEETSQKLLLNEAIAEGLVSSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2726)

LMGKLNMFRGFFDSQTSESL
TTEEVIDEGLMDEKLL-HKVLMSDK

PF00681 // ENSGT00760000119163_1_Domain_14 (2726, 2759)

AISGILDPRTNSLCSVKEAVASGLLDKEIATRILEGQVVTGGIVDLKRGKKLSVTLASNFGLVDNADHTELINLEKATKGRDADKAVKERLIGLQMETTGLMDPDSKAPLTVLQSIDRGLLDREEAVSLLAKQVLDGGIIHHISGLRLSVDNAFKHGLIGEDEARHLKRIENLNYHQFFHPQTKEPLSFSEAIKLGLVSPELKREIQEIQDYSGNLGDLIYGQKLSLAEANKGGSLA----NKTELPSGIMHGVVDPENCKTIPYSELVKKCRIDIESGWRYLEVIPFSDIKDEVSNKELTLSEAIQHGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASAMEQKLLDENMARIIAS-----HQVLSGGIIDIYNDQRVTLKDAVEKRFVSPELAAMIQADTLEN-----------QGRTEVCELKGEFPRKESLVEGSLTAR-----GSYEKEEHE-QIGSKCAREKVEVRISNGR-------KTEKDRKISLKEMEGKSHAEEKASLD---NNVSANIVSPGGLGGEPS--HQVLVMHPG--SEASDLKLREVATSCMRKFVD----IEQEKVVTQIKMISHVKQS-ASGLDAEETTEYQGEMIS-QGQE-SHYEAT------GKLLSEQPV--NVQV--SKR--EKRD-MVVKESVQKGKAAFVSKEKLDQGITISEEH---MKSQSMRMIRNDKGKVT-GREMD-SSVCKTEGFPS-QMTCKDTSLRNPDGLTC-----F----SKGEMK-----------TVNLCSILKPGEKLYQEIASAAQK-EPFSSEIPRP-EGLNYQGSDGEAQVSDIRRISK-KDMASQRTSRQETTDGQD-LCATSQTEETE--DKIFP---H-RD-DKEKL-YQEIPLDSMRA-------------------HKW-KE--TISSVATEEAIHLDRSDSKGLHEDSNGDQKS------------KIAKTQETAFLEVVNPI-IRDPEE--GSSENRVGRKGPGVLVSLFPEKLP--KGIL----QKESINQHDAV-ISPTVSEVSEEMS-VTLP-SSTMKTDE--------------KIPQEKYKENLGE---------EQ------APSMAVPGGKGREGV--NPAPC---RATQNVFT--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL----GLHMAELQDLLCQAKVLDQELKDLSTVVNQELECVHQIVTSQPQEVPVQLLKALEKDAKNLQKSLDSVSVSWSSRLLHLQSAV-EVKQTTVLNQHKELEGKLQDLRAWLDRTSLTLNSKGCDSE--T-DVDSPSHSLQQYSNMKQSLTERKSQLDVLALDIQLFISEHAQDLSLQQKQQMLQSLNELQRSFQDLVEQTAAQMDALQGYLQQIQQEVQVK-TLQKQQNTCHQKLEDMCSWVGQAERALVRHQ-GGASQQELSALQKNQSDLKDLQDDIQNRSASFASAVKDIEGFLEENQTKLSPQELTSLQEKLHQAKVQYEVLQERTRVAQKELEEAVTSALQQETEKSKAATELAENRRKIDALLDWVASVG----------S--SERQPQTSLLGMEQFSGAS--LEKPALDATDGC-VEVNQVPEKLDRQYELMKARHQELLSQQQNFIVATQSAQAFLDQHGHNLTPEEQQKLQEKLCKLKEQYATSLAQSEAELKQTQTLRDELQKFLQDHREFDSWLERSENELDSMHKGGSS-PEALYSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-EN-FEEGQEPS---ATRNLVNEKLKDATERYTTLHSKCTRLGSHLNMLLGQYQQFQSSADSLQAWMLTCEASVKKLLSDSVASDPAILQQQLATT-K--QLQAELAEHQVPVEKLQKATRDLIEIEGEPALDHRPIQE-TTDSIFSCFQGLSCSLAERSALLQKAIAQSQSVQESLESLLQSMREVEQNLEGEQVASLSSGVIQEVLANNMKLKQDIARQKSSLEATHEMVTQFMETADSAT-ASVLQGKLAEVNQRFEQLQHQQQEKESNLKKLLPQAEMFEQLSNKLQQFMENKNRMLASGNQPDQDIAHFSQQIQELTLEMEDQKENLDTLEHLVTALGSSGFALDLSQHQDKIQNLKKDFIELQKTVQEREKDASCCQEQ-------LDEFRKLVRTFQKWLRETEGNVPPTETFLSAKELEKQIEHL------KG-----LLDDWASKGILVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNSKYEKLGEVLRERQESLQAVLSKMEEVQKEASSVLQWLESKEEVLKAMDASLSPTKTETVKAQAETNKAFLAELEQNSPKIQKVKEALAALLGTYPNSQEAENWKKMQEELNSRWEKATEVTVARQKQLEESVSHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSPSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAISTQPDAVKQQLEETSEIRSDLGQLDNEIKEAQTLCDELSLLIGEQYLKDELKKRLETVTLPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDEKQSQQAKICPISAKLERLQSQLQENEEFQKNLNQHSGSYEVIVAEGESLLLSVPPGEEKKTLQNQLVELKSHWEDLSKKTADRQSRLKDCMQKAQKYQWHVEDLIPWIEDCKAKISELRVTLDPVQLESSLLRSKAMLSEAEKRRSLLEILNSAADILINSSEVDEDEIRDEKAGLNQNMDAITEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASPLVHQAEVAQQEFLEVKQRVNSGCLAMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRIFLNKIQALRFDIEDSEAECRKMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKALSDATAAAEEGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQVKLQQVNGLGQGLIQSAGKNCDVQGLEHDMEEINTRWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLNKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIHQQIIRHK-------------------------------------------------------------------------------------------------------------ALNEEIINRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFHSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSHALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ--------QVMFIMLCIRVFKLWGTSGIQKQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFSTCGEEQKAVLQEKTECLIQQYEAVSLLNSERYARLERAQVLVNQFWETYEELSPWAEETLALIAQLPPPAVDHEQLRQQQE-EMRQLRESIAEHKPHIDKILKIGPQLKELNPEEGKMVEEKYQKAENMYAQIKDEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARSEEREMKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGTDLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELRHLWENLDEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTLQ-QAQGFHSEIEDFLLELNRMESQLSASKPTGGLPETAREQLDTHMELHSQLRAKEETYNQLLDKGRLMLLSRGDSGSGSKTEQSVALLEQKWQVVSSKMEERKSKLEEALSLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFYEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLADDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTESLQSLIDTHKEFMKKVEEKRVDVNTAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLEAALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALITEHQSFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKPRGGSR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2791)

RILE
GQVVTGGIVDLKRGKKLSVTLASNFGLVDNADHTELINLEKATKGRDADKAVKERLIGLQ
METTGLMDPDSKAPLTVLQSIDRGLLDREEAVS

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2892)

LLAKQVLDGGIIHHISGLRLSVDNAFK
HGLIGEDEARHLKRIENLNYHQFFHPQTKEPLSFSEAIKLGLVSPELKREIQEIQDYSGN
LGDLIYGQKLSLAEANKGGSLA----NKTELPSGIMHGVVDPENCKTIPYSELVKKCRID
IESGWRYLEVIPFSDIKDEVSNKELTLSEAIQHGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3081)

VLEAQANTGGIIDTATG
KRLTLASAMEQKLLDENMARIIAS-----HQVLSGGIIDIYNDQRVTLKDAVEKRFVSPE
LAAMIQADTLEN-----------QGRTEVCELKGEFPRKESLVEGSLTAR-----GSYEK
EEHE-QIGSKCAREKVEVRISNGR-------KTEKDRKISLKEMEGKSHAEEKASLD---
NNVSANIVSPGGLGGEPS--HQVLVMHPG--SEASDLKLREVATSCMRKFVD----IEQE
KVVTQIKMISHVKQS-ASGLDAEETTEYQGEMIS-QGQE-SHYEAT------GKLLSEQP
V--NVQV--SKR--EKRD-MVVKESVQKGKAAFVSKEKLDQGITISEEH---MKSQSMRM
IRNDKGKVT-GREMD-SSVCKTEGFPS-QMTCKDTSLRNPDGLTC-----F----SKGEM
K-----------TVNLCSILKPGEKLYQEIASAAQK-EPFSSEIPRP-EGLNYQGSDGEA
QVSDIRRISK-KDMASQRTSRQETTDGQD-LCATSQTEETE--DKIFP---H-RD-DKEK
L-YQEIPLDSMRA-------------------HKW-KE--TISSVATEEAIHLDRSDSKG
LHEDSNGDQKS------------KIAKTQETAFLEVVNPI-IRDPEE--GSSENRVGRKG
PGVLVSLFPEKLP--KGIL----QKESINQHDAV-ISPTVSEVSEEMS-VTLP-SSTMKT
DE--------------KIPQEKYKENLGE---------EQ------APSMAVPGGKGREG
V--NPAPC---RATQNVFT--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--GLHMAELQDLLCQAKVLDQELKDLSTVVNQELECVHQIVTSQPQEVPVQLLKALEKDA
KNLQKSLDSVSVSWSSRLLHLQSAV-EVKQTTVLNQHKELEGKLQDLRAWLDRTSLTLNS
KGCDSE--T-DVDSPSHSLQQYSNMKQSLTERKSQLDVLALDIQLFISEHAQDLSLQQKQ
QMLQSLNELQRSFQDLVEQTAAQMDALQGYLQQIQQEVQVK-TLQKQQNTCHQKLEDMCS
WVGQAERALVRHQ-GGASQQELSALQKNQSDLKDLQDDIQNRSASFASAVKDIEGFLEEN
QTKLSPQELTSLQEKLHQAKVQYEVLQERTRVAQKELEEAVTSALQQETEKSKAATELAE
NRRKIDALLDWVASVG----------S--SERQPQTSLLGMEQFSGAS--LEKPALDATD
GC-VEVNQVPEKLDRQYELMKARHQELLSQQQNFIVATQSAQAFLDQHGHNLTPEEQQKL
QEKLCKLKEQYATSLAQSEAELKQTQTLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4506)

ELQKFLQDHREFDSWLERSENELDSMHKGG
SS-PEALYSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-EN-FEEGQEPS---ATR
NLVNE

ENSGT00760000119163_1_Linker_24_25 (4506, 4534)

KLKDATERYTTLHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQAWMLTCEASVKKLL
SDSVASDPAILQQQLATT-K--QLQAELAEHQVPVEKLQKATRDLIEIEGEPALDHRPIQ
E-TTDSIFSCFQGLSCSLAERSALLQKAIAQSQSVQESLESLLQSMREVEQNLEGEQVAS
LSSGVIQEVLANNMKLKQDIARQKSSLEATHEMVTQFMETADSAT-ASVLQGKLAEVNQR
FEQLQHQQQEKESNLKKLLPQAEMFEQLSNKLQQFMENKNRMLASGNQPDQDIAHFSQQI
QELTLEMEDQKENLDTLEHLVTALGSSGFALDLSQHQDKIQNLKKDFIELQKTVQEREKD
ASCCQEQ-------LDEFRKLVRTFQKWLRETEGNVPPTETFLSAKELEKQIEHL-----
-KG-----LLDDWASKGILVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNSKYEKLGEVLRERQESLQAVLS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

KMEEVQKEASSVLQ
WLESKEEVLKAMDASLSPTKTETVKAQAETNKAFLAELEQNSPKIQKVKEALAALLGTYP
NSQEAENWKKMQEELNSRWEKATEVTVARQKQLEESVSHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSPSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPDAVKQQLEETSEIRSDLGQLDNEIKEAQTLCDELSLLIGEQYLKDELKKRLETVTLPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDEKQSQQAKICPISAKLER
LQSQLQENEEFQKNLNQHSGSYEVIVAEGESLLLSVPPGEEKKTLQNQLVELKSHWEDLS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLIPWIEDCKAKISELRVTLDPVQLESSLLRSKAM
LSEAEKRRSLLEILNSAADILINSSEVDEDEIRDEKAGLNQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASPLVHQAEVAQQEFLEVKQRVNSGCLAMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRIFLNKIQALRFDIEDSEAECRKMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKALSDATAAAE
EGEALQWVVGTEVDVINQQLADFKMFQKEQVDPLQVKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINTRWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLNKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6235)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIHQ
QIIRHK------------------------------------------------------
-------------------------------------------------------ALNEE
IINRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFHSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSHALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ--------
QVMFIMLCIRVFKLWGTSGIQKQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFST
CGEEQKAVLQEKTECLIQQYEAVSLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWAEETLA
LIAQLPPPAVDHEQLRQQQE-EMRQLRESIAEHKPHIDKILKIGPQLKELNPEEGKMVEE
KYQKAENMYAQIKDEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARSEEREMKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGTDLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELRHLWENLDE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELNRMESQLSASKPTGGLPETAREQLDTHMELHSQLRAKEE
TYNQLLDKGRLMLLSRGDSGSGSKTEQSVALLEQKWQVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7137)

EALSL

PF00435 // ENSGT00760000119163_1_Domain_47 (7137, 7240)

ATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFYEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLA
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTESLQSLIDTHKEFMKKVEEKRVDVNTAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLEAALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALITEHQSFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKPRGGSR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------IPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKATHS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GECHQIMKNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENE
DKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDE
EIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-ETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKA
YHDLCDGSANQLQQLQSQLAHQTE------------------------------------
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---------------------------------------QK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSGAS--LEKGALDTTD
GY-MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML
QQKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHKEFESWLERSEKELENMHKGG
SS-PETLPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQACEANVEKLL
SDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVHKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRINRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM
TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6127)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPSPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLEAMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA
-----------------------RGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTK--------------------------
-----------VIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVILSGLIAPETSETLSLDDGLARNLIDPQMYHQLREL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

QDALSLMGM-FTE
GKG---SLSVMEAIENRRISERIG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKILEAHLATGGFSLSPSENYITLEEAFHQGLVTPQ
FYSMLESYLKSSKNLIDPNTAEKISLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLQSGR
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX---XXXX--------XX-XXXXXXX-XXXXXXXXX
XXXXXXGQRLLLLDKELIDTLT--SRDEHE-TGLP---EVFGSRHQRLDMSEGLQD--SS
TVKITEA-FSDALKLRSHEFQFSSQNREYPDQENCTETESQKAIVETEGSY--------M
EDSGKDLFVGQQTVRNSNADSLK-VLSKKENQTEVSTGKNASG-----------------
---HLIVP-PEEGGGFNLVVDKDPLSVDTPKAE------GQALIGCQKEQA--STLEIEH
IPGETRRKL---INPQSKKLLFQVE-KTLDLKSELKSENDRNISSLDKEKMVNKMPL---
----YGGD--HKQNQEENIA--GGNVMVLGKKA-EEENSDNPLSCS----HPSECLEETT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2685)

LNVLSAQLLDGGIAHEQTGQKLLLNEAIAQGIIPSHTAVKLMEK

ENSGT00760000119163_1_Linker_13_14 (2685, 2718)

FKMFRGFFDSQTHESL
TTEEVIDEGLMDEKLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2762)

HNVLLSDKAISGVLDPRSHTLCSVKDAVAVGLLDKQTATRILE
G

ENSGT00760000119163_1_Linker_14_15 (2762, 2763)

Q

PF00681 // ENSGT00760000119163_1_Domain_15 (2763, 2800)

VVTGGVVDVKRGKKVSVTLASNLGLLDSADQTELISLEKASKGRDAKKSVRERLIRLQ
METTGIMDPGTKAPLTVAHAIDKGLLDREEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

IQFLAKQVIDGGIIHHISGMRLSVDNAFK
HGLINEDLSRQLKKIEDLYLHQFVHPRTKETVSLSDAMKLDLITPDVKREXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX-----XXXXX
XXXX-XXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXX---
XXXXXXXXXXXXXXXXXX--XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX----XXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX-XXLG-VYWECS------SRLLTEQA
TQERLNI--KVKRKRENREMIVKESARTCKPAVLSKEKLNKESAAIDEPDSQIKSQSVEI
TIPEGRKEV-DRDPVLSMIYKAEDTSS-TMVSKGISISNQDALASV----N----SGREV
N-----------NLSICLTLKPEENLSQKITGEAKSCEPFSPMTLTP-AGLHDKESLAKA
HDTDTSQFSK-ANKSIGNI-MQETNYYQD-FCVTFKTKGTK--DRFYP---S-NE-WRKX
X-XXXXXXXXXXX-------------------XXX-XX-XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX------------XXXXXXXXXXXXXXXXX---------XXXXXXXXXXX
XXXXXXXXXXXXX--XXXX----XXXXXXXXXXX-XXXXXXXXXXXXX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXXXXXXX
X--XXXXX---XXXXNVYN--------RRLCLEHDERLVSYLSLLRDIEMRTKQIQPL--
--ELRLTELQDLLCQAKVLDKELKDLSTLVCQELECVNQIINSQPQEVPVQLLKALEKDA
KNLQKSFSSVGDTWSSRLLNLQNAV-EAKKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXR
QMLRLLNELQRSFQDLVEQTAAQRDALQGHLQHLEQAAGVK-TLQ

PF00435 // ENSGT00760000119163_1_Domain_23 (4126, 4239)

KQQNTCHQKLQDLCS
WLGQAERTLAGHQ-GSAIPQDLSALQKTQSDLKDLEDDIQNHATSFANVVKDVEGFLGEN
QTKLSPHELTALQNKLRKTKEQYETLQSQTRVAQKELA

ENSGT00760000119163_1_Linker_23_24 (4239, 4410)

EAVTSAVQQETEKSKAAKDLAE
NRNKIDALLGWVTSLG----------S--SGRELQAGLPGMEQISGVN--LEKGALDATD
GN-MRVHQAPEKLDEQCEKIKAYHQELLSQQQNFIMATQSAQTFLDQHSHNLPPEERRVL
QEKLGELKEQYAASLAQSEAELKQVQTLR

PF00435 // ENSGT00760000119163_1_Domain_24 (4410, 4530)

DELQKFLQDHREFENWLERSEKDLENMHKGD
SN-PEVLPSLLKRQGSFSEDVISHKG-DLRFVTMSGQKVLDT-ENSLEKGSEPS---AAG
NVVKEKLRDATGRYSALHSKCARLGSHLN

ENSGT00760000119163_1_Linker_24_25 (4530, 4533)

MLL

PF00435 // ENSGT00760000119163_1_Domain_25 (4533, 4628)

GQYQQFQSSVDSLQAWMRTCEASVEKLL
SDTVASDPGNLQQQLATT-K--QLQEDLAEHQVPVEKLQKVAHDLMEIQGDPAPDHKHVQ
E-TTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXKLKQDIARQKSSLEATREMVTRFMETADSST-ASVLQGKLAEVSQR
FQQLCLQQQEQESSLKKFLPQAEMFEHLSEKLQQFMENKNRMLASGNQPDQDIAQFSQQI
QEFNLEMQDQQENLSTLEDLVNDLSSYGFAPDLSQHQEKVQNLKKDFTELHLTIKEXXXX
XXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----
-XG-----LLDDWERKGTLVEEINSKGTSLENLIMEITAPDSQVKTXXXX---XXXXXXX
XXXXXXXXXX-XLTEIQCDMSDVNLKYEKLGEVLREHQESLQAML

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

SKMQEVHKEASSVLQ
WLESKEEILTAVDASSSPTKTETVRAQAESNKAFLAELEQNSPKIQKVKEALAGLLMTYP
NSQEAENWKKMQEDLNSRWERATEVTKARQRKLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5138)

ESA

PF00435 // ENSGT00760000119163_1_Domain_29 (5138, 5246)

SHLACFQAAESQLRPWLVEKELM
MGVLGPLSIDPTMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSPSTSHVQ
QELQSINQKWVELTDKLSSRSNQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPEAVKHQLEETSEIRSDLEQLDNEIKEAQILCDELSMLIGEQYLKDELKKRLETVALPL
QVRXXX------XXDRMNRLQAAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLDDKQSQQAKICPISAKLEQ
LQSQLQENEEFQKSLNQHSGSYEVIVGEGESLLLSVPPGEEKRTLQNQLVDLKSHWEELS
KRTADRQSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVENLMPWIEDCKAKMSDLRVTLDPVQLESSLLRSKAM
LSEVEKHHSLLEILNSAADILINSSETDEDGIRDEKAGINQNMDTITEELQAKTGSLE

ENSGT00760000119163_1_Linker_32_33 (5579, 5691)

EM
AQRLKEFQESFKNIEKKVEGAKHQLEIFDALGAQACSNKNLERLRGQQEVLQALEPQVDY
LRNFTQGLIEDAPEGSDASQLLNQAEVAQQEFLEVKQRVSSGCMMMENKL

PF00435 // ENSGT00760000119163_1_Domain_33 (5691, 5797)

EGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKSDVEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE

ENSGT00760000119163_1_Linker_33_34 (5797, 5800)

LTL

PF00435 // ENSGT00760000119163_1_Domain_34 (5800, 5908)

GRVEDFYRKLKVLNDMTTAAE
EGEALQWVVGSEVDVINQQLADFKTFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDIEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5911)

EAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAESAELADREKITGQLQSLE
GRWTELLNKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6022)

DIL

PF00435 // ENSGT00760000119163_1_Domain_36 (6022, 6128)

VLAKQFHETAEPISDFLSVTEKKLANSEPVGTQAAKIQQ
QIVRHKALEEEIESHATDVHQAVKIGQSLSSLTCSTEQGVLSDKLDLLQARYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVCVKDYRQDVLQKQHADHLALNEE
IVNRKKTVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITITSSKALRTLEQARQ
LATKFQSTYEELTGWLRKVEEELAASGGQSPTGEQIPLFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDARQYL------ISDTIDKVDEDA

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

AQRSLYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGEEQKTLLQEKTESLIQQYEAISLLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELNPWIEETRA
FTAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQQAENMYAQIKEEVRQRALALD

ENSGT00760000119163_1_Linker_40_41 (6565, 6577)

EAISQSA---QV

PF00435 // ENSGT00760000119163_1_Domain_41 (6577, 6688)

SGSSK-FHDKIEPMLETLENLSTR
LRMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALERRGEELIGRSQGADKDMAAKE
IQDKLDQMVFFWEDIKARAEEREMKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWCDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWRERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQAMFDWLDNTVIKLCTMAPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAYRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLIHTEELLDAQRPVNGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

STLQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMENQLSAAKPTGGLPETAREQLDTHMELYSRLKAKEE
TYNQLLDKGRLMLISRDDSGSGSKTEQSVALLEHKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQSLNIAPPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7355)

EA

PF00435 // ENSGT00760000119163_1_Domain_49 (7355, 7461)

LV-SGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7586)

KQAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRMDVNAAVAMGEVILAVCHPDCITTIKHWVTIIRAR
LEE---LTWKQHQQR-----ETALS

ENSGT00760000119163_1_Linker_50_51 (7586, 7588)

LA

PF00435 // ENSGT00760000119163_1_Domain_51 (7588, 7720)

NAELEELLAWIQWAE-TTLLQRDQEPIPQNIDR
VKALIAEHQMFMEEMTRKQPDVDRVTKTYKRKSVEPTHGPFIEKSRSGGR---KPLSQPA
PPPMPIFSQAEAKNPRINQLSARWQQVWLLALERQRKLN

ENSGT00760000119163_1_Linker_51_53 (7720, 7763)

DALDRLE-----E-----LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFP--LIPQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCASMPSSPATPASGTKV-------------------------
------------IPSSGSKLKRPTPAFHSSRTSLAGDTSSSSSPASTGAKANRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSTAGGLGNSRRGP--NKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------LTDERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLIK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGVQL--------------------------
---------PREKGRMRFHRLQNVQIALEFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 443)

QISDIYISGTTGDLTA

PF00307 // ENSGT00760000119163_1_Domain_2 (443, 543)

KEKLLLWTQKVTAGYVPVKCTNFSSCWNDGKMFNAIIH
RYRPDLVDMQRVEIQSSRENLEQAFEIAERLGVTRLLDAEDVDVDSPDEKSVITYVSSIY
DAFPKVPEGGDGISATEVDRRWTEYQGSVESLLSWVKQHTIIMSDKSFPQNPVELKALY-
NEYIHFKETEIPAKQQEKRSIEELYKLLEVWIEFGRMKLPQGFHPNDVDEEWGKLVIEML
EREKLLRPAVERLELLLQIANKIQNGTLCCEEKLTLARNTLQADEAHLESAQAVQHESDV
VLYLQECEELLYQLQADVQILRDENYYQLEELVVKMVRLQDELVTLKLECANLYRKGHFT
SSSSSPSSDIVQPSSLHTGGRLKANPLLKGLHTATTASAAAAIAIAASASSWFRKPMSRS
ELVAASSSEDEGNLRFVYELLAWVEEMQMKLERAEWGNDLPSVQSQLEVQRSVHSGVEDL
GSSVKEARMYENKMSQNFRT-SYTETLGKLEVQYCKLMETSSFRLRHLQSLYEFVSLATA
ELIWLNGKEEEELAYDWSDNNPNMAAKRNYFTELTMELEEKQ-NIFHSLQDTAEL-----
FSLENHPAKQTVEAYRAAMQTQWQWIRQLCLCVEQHVKENTAYFQFFSDARDSESYLKSL
QDAIKRKYSCDRNTSLTRLEDLLQDSM--DEKEQLIQAKSSVASLVGRSKSIVQLKPRNP
DHVLEGTISGPSDCDYRQIEITICRNDECVLEDNSQRIQWKVISPTGNEAMVPSVCFLVS
PPNKEANDVASRVEQLYQKTMALWHKLHINMKSLVSWNYLKKDISVVQGWSLEKLRALPS
GECHQAMRNLQL----HYDDFLEDSRDSELFSAAHRLRLKEEVDACKEKFQQLMQSMENE
DKDETASRTYLSELKNIRLHLDECEQRLVGTIRTPSSTRTDGDALQG-TFRIAEQERLKE
DLQNLKADLEQFSERCSIFLLKSPTGSSTPHLRSELNLLVEKMGLVHGLSSVYLDKLKTV
DVIIRNTQGAESLVKGYEVKLSQEEAVPTDLAAIRAHQTTLQQWTSEVKDKKAVFTALEE
DLSRAKVVAEQLFRLKQERSVDLERYQEKGAQLWERWQRVG-LQVETRQSDLESIQDVLG
DYRSCHGALIRWIEETTAQQEAMKPGQAEDSRVLSEQLSQQMALFAEIEANQAKLDQCQK
LSQQYSAAVKDYELQLMAYRAFVESQQKSPVKRRRMLSSSDTITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKLEHVDKVKALLGWVSNFKQSSQFKNMPP-ESKDL
GDIEKSILEQQVLNEELAAKKEQVSEAIKTAQMFVARHNNKLSGQEKEVILAQLDVLRET
YDQLCSESSDQLQQLQSHMAQETAHKGTET--VAGVLDLGT--MEVVPIWGAMQKGLLDQ
ETGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1908)

LLLEAQVASGGLLVPDTGEKISLSEGLAKDIIDAKTYAMLQELQSGVQLVNSHDFQ
GKP---LLPLAAAMEDGTISERVGLTIAKMQILAGGLHDPSGDGRIGLEEALQGGMIPPH
LHEKMASCLDSCKTLIDPNSAKKTGLSELQQQCLPDPETGLRLLPVHQLAGGMVSLTSGQ
KVNIFRAVQEGLIEMQVAV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2102)

RLLEAQLFAGGIVDPKSGHRLTVEEAARHNLIDQDLACALL
V

ENSGT00760000119163_1_Linker_10_11 (2102, 2103)

R

PF00681 // ENSGT00760000119163_1_Domain_11 (2103, 2135)

QMQTGGIVDTVTGERLSLDEAVRKDLVEPRMAVATLESLWSFMGLLQPESGEILPVAT
ALDRGILSSELADEILSKRQHIEAVFIPETREIMSWEKIMDAGILSQDAAKTLKSMLLPD
VMPNVPLADSPPGRVRNISPTNRK-----------------DQSEECKER-MLFYLMTHS
YVDACSGQKLLLLTEEELNTLADIVEPTIE-KDP----HSQPME-ERQHQPKGWEVVEDR
MVATVESEPHSELAWKELELNLSAPQKELERNL-----------MPGVCFPIHWNEREAG
DLPGKEVERGMKVKEEKEVDSLE-G-------FGSEMGGSKREAEQIMIQNASEADLLIC
ESIEEPSP-GKELRDIKITLDSVKFD-------KQ-P--AEEEMMFSEEQKKVSEMERSY
IEKESRMA----VDLQSLKENVMKK-AILAATSEG-----SEVNLLNAGKVENGSIESLI
CQ--DEGKISGEPIKEEEAVSGEG--------RVGHSDQTESVAFP----KPSTEEGDDT
LHTLITQLYGGGIINEQTGKRMLLDESVSCGVLPGHTAIKLMGELKLFGGFFDAESCEAL
TTEEVIHEGLMDETLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2760)

QKVLDSDQAISGVVDPRSKAIYSITDASEVGLLDKETAARILEGQVVTGGIADVKRGKKVSVTLASKLGLVERPIQEELKKLEKASKGKGMDGATKEKLISLQAEIGGIVDPKTKEPLTVPQAVEKGLLSKEKASEVLMKQIVDGGILHHKTGMRLSVEDALVHKLIDQGLYDNLRKAENVCFHQYIHPETKELISLPQAVALGLISSGFQSKVQGMQASTGSVFDPVSHQKIPLTKAVKEGLLPKAVMEKAVTSADMKHAILDPESCGLVPYSELVRKSRIDIESGQRYLEVVPFRDLKDERTGNVLLCPQAVKLGKVEPALVSRLLQAQAESGGIVEPATGQRLSLADALERGMVDEDMAKAIAV-----SQLSTGGIVSTERGQRLTLMEAVEMGLVSKKLASAIQPQLLLQNGTSKTDARRQDGVGAGLDVRSSWS---------PATE--GPEERHEEEEPF-A----------EGRAPERRGRKARS---KENEKVGIESEVPATVD-ESQTPTSEEALFGDTKIEPSGMASE------LRSQDPNASESTCVEVPKKMKKKTKRNRKQVTA----TKDPAQLPESSHLRPSEIPILVSKEVLVQRTS----AVQKSSQGNISGKKVR-GLLKPEEADDKREDREASGKEEKGGKENITDDQKVSTVPTTDAFGELAQQQEIRTDQDSPLALDAVEIKIEEKVFQEKAQELRL----------SNDEVPKLVAID--DTQTFVSSE--------TEVV--------------------QNRTILQGETGSSAS-------TP-----------------------SLSQDKTIQGVTREDDSIAAKGLTMDEEPEETRDIDCLRSKISSPEEWTLQRSGYPEGKRDP----SPKTQDSVSKLAGEKEKADEL-SS-----AVEGREE-----------------------------------RPPDAPKLTK-------------VGSPQGKISLTFVLGIIRFWKMSLVVETRIG----QKASVGMPFPLIITLSIVDLLSEKLARGNAYISVAEINKYFRWKCFYK---------------------INGYIY--ILARAYFPFQNIPLVKSEGGF--GKEDC---CSVVAIFT------LSKQLCLDHDEKLVALLSRVRDVEMRIQRVPLL----EQDSAALQDLLRQAEALDAELQGLSSPVSQGLEAAQNLLASPPLQVPEQLLKALEKDAKNLQKSFSSVSEALASWLTNLQAAAKEEEKTKVRTRHEELQRNLQGLLTWVSDTTQSLNGLDFPGAKTAEDPGALHSCLQSYKDLKEPLADTKAQLDAAALDIQFFISENAQDLSPEQSRQLLRLLNELQGSFRELSGRVAAQTEVLRVCLLRAEQTDQVTQTLQEQQVIRSRNLEELCSWMNQAEARLQDPQ-GAMHKGELSLLEQKQSDIKDLQRNMHSRSASFAGILKATEEFMEDNQAKLDPQELASLRARHGQAKEQLQSLQERVEATHKELESAVSTVVQQQTQKVKAVKDFEENHNKIESLLHWMSSLE----------KS--RESTKSRSLSLSQKAGDQ--KDGRTPDTPDGRPVEADRVEEGLDLHFQSLKAHHQELLSQQQEVLLSAQSAQAFLEKRGHNLSPAETQQLQGKLDELKDQYASKLSQSEAQLKQVQSLQDELQKFLRDHLEFEAWLLQAEQELDRMHHGDGG-LEALRPMLHRQSSFSEDVISHKG-DLRFVTMSGQKVLDAEK--ATAGPEVS---STGALVTSKLEDATKRYGTLHSKCAALGSHLNLLLDRSQQFQDIANSLQTWLQRSEAAVSNLLSEPISSDPAILQKQLASA-K--RLQEDLAEHQVPVEKLEKASRSLLEIHQAPVPDHKSIQE-TTASVMSRFQGLWGRMAERSDLLQKAIAQSQSVQEGLEGLARSMAHIEESLQRQEGTPFSAAAVQEALANNTKLKQDLDRQRSLLEATQGMVARFAEAAESGAAAAALRSQLDSLTERFGSLCQRRQKEEETLKELLPKVEQHEQLSQALEQFTETRGRMLAAGNQPHHDIGHFSQQIQGCRCS------------------QECGYTFSLSKSDIF--------TPP-RLHLHCRVNAESCKDVAQGMPGCFDVFTILMGGFSH--------VPTAMEMIDRIEITVFIFHPSHPEGHSG-----RITLYTY----KANIQC---------YNIEQRQRQTQRVCLI---PAAGGAAALCNGQGLYF----IFNCQVLTP--T---WAGLLVRV-IYCSWLLTSLLTSLRHSTISFCWMRAANALFNVPKLTFSLS-FVAFFFPSSFSQVFLTELEQNSVKVQKAKESLSGLLQKYPDSPEAGNWKRTLEDLDSRWERANQVTTERQQKLEKSARELASFQVAEGQLRPWLTEKELMMSVLGPLSIDPNMLSAQKQQVQFMLKEFESRKPQFDQLNAAAQGMLTGPE-ASPSAGHMQDDLQAINQTWTALTERLDSRSAQIDQAMVKSTQFQALLQSLSEKVKAAGQRLSPQLAASTQPEAVKRQLEEASEVRSDLEQLENNMSEAQALCEELSVLIGEQYLKDELKKRMEAVALPLRGLQDL------AADRMNRLQTALASSQQFQQMFDELQVWLDEKVRCQAQAGPISAKLERLQTQIQEQEELQKSLNQHSGSYEMIVAEGESLLVSARAGEEKARLQGQLTNLKARWEELSKQAADRHAKLKDCLQKAQKYQRHVEDLFPWVEDCRSKVTELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADVLINASEMDEDDVRDEKAGINQKMDAITEELQAKAGSLEEMSQRLKEFQESLRNIEKKLEGTKHQLEIYETLGPQACSNKNLEKLRSQQEALRALAPQVDYLKNFTRGLVEDAPDGSDSSHLLRQAEAAQREFEEVGQKVSECCTLMESKLEGIGQFSNHVREMFSQLADLDDELDGMSPVGRDLDSLQSQAEDMHDFLGKLQRLKQDIQASEEKCREMLDDEGSPDLVGLRRELETIHKQCGKLADRGRGRLEQVEAALSRLRDFYGKLRELTAMAATAEESEALQWVVGTEVEAINQQLADFKLFQKEQVDPIQLKLQEVNGIGQGLIQSAGKNSDVQGLEHDMEDINARWNTLNKKVAHRTAQLQEALLHCGKFQDALEPLLSWLTDTEELISNQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIHAEGGRIAQSAEPADREKIAAQLESLGGRWEGLLSKAMAR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2797)

RILE
GQVVTGGIADVKRGKKVSVTLASKLGLVERPIQEEL

ENSGT00760000119163_1_Linker_15_16 (2797, 2820)

KKLEKASKGKGMDGATKEKLISL

PF00681 // ENSGT00760000119163_1_Domain_16 (2820, 2854)

Q
AEIGGIVDPKTKEPLTVPQAVEKGLLSKEKASE

ENSGT00760000119163_1_Linker_16_17 (2854, 2854)

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2896)

VLMKQIVDGGILHHKTGMRLSVEDALV
HKLIDQGLYDNLRKA

ENSGT00760000119163_1_Linker_17_19 (2896, 2935)

ENVCFHQYIHPETKELISLPQAVALGLISSGFQSKVQGM

PF00681 // ENSGT00760000119163_1_Domain_19 (2935, 2964)

QASTGS
VFDPVSHQKIPLTKAVKEGLLPK

ENSGT00760000119163_1_Linker_19_20 (2964, 3043)

AVMEKAVTSADMKHAILDPESCGLVPYSELVRKSRID
IESGQRYLEVVPFRDLKDERTGNVLLCPQAVKLGKVEPALVS

PF00681 // ENSGT00760000119163_1_Domain_20 (3043, 3081)

RLLQAQAESGGIVEPATG
QRLSLADALERGMVDEDMAKAIAV-----SQLSTGGIVSTERGQRLTLMEAVEMGLVSKK
LASAIQPQLLLQNGTSKTDARRQDGVGAGLDVRSSWS---------PATE--GPEERHEE
EEPF-A----------EGRAPERRGRKARS---KENEKVGIESEVPATVD-ESQTPTSEE
ALFGDTKIEPSGMASE------LRSQDPNASESTCVEVPKKMKKKTKRNRKQVTA----T
KDPAQLPESSHLRPSEIPILVSKEVLVQRTS----AVQKSSQGNISGKKVR-GLLKPEEA
DDKREDREASGKEEKGGKENITDDQKVSTVPTTDAFGELAQQQEIRTDQDSPLALDAVEI
KIEEKVFQEKAQELRL----------SNDEVPKLVAID--DTQTFVSSE--------TEV
V--------------------QNRTILQGETGSSAS-------TP---------------
--------SLSQDKTIQGVTREDDSIAAKGLTMDEEPEETRDIDCLRSKISSPEEWTLQR
SGYPEGKRDP----SPKTQDSVSKLAGEKEKADEL-SS-----AVEGREE----------
-------------------------RPPDAPKLTK-------------VGSPQGKISLTF
VLGIIRFWKMSLVVETRIG----QKASVGMPFPLIITLSIVDLLSEKLARGNAYISVAEI
NKYFRWKCFYK---------------------INGYIY--ILARAYFPFQNIPLVKSEGG
F--GKEDC---CSVVAIFT------LSKQLCLDHDEKLVALLSRVRDVEMRIQRVPLL--
--EQDSAALQDLLRQAEALDAELQGLSSPVSQGLEAAQNLLASPPLQVPEQLLKALEKDA
KNLQKSFSSVSEALASWLTNLQAAAKEEEKTKVRTRHEELQRNLQGLLTWVSDTTQSLNG
LDFPGAKTAEDPGALHSCLQSYKDLKEPLADTKAQLDAAALDIQFFISENAQDLSPEQSR
QLLRLLNELQGSFRELSGRVAAQTEVLRVCLLRAEQTDQVTQTLQEQQVIRSRNLEELCS
WMNQAEARLQDPQ-GAMHKGELSLLEQKQSDIKDLQRNMHSRSASFAGILKATEEFMEDN
QAKLDPQELASLRARHGQAKEQLQSLQERVEATHKELESAVSTVVQQQTQKVKAVKDFEE
NHNKIESLLHWMSSLE----------KS--RESTKSRSLSLSQKAGDQ--KDGRTPDTPD
GRPVEADRVEEGLDLHFQSLKAHHQELLSQQQEVLLSAQSAQAFLEKRGHNLSPAETQQL
QGKLDELKDQYASKLSQSEAQLKQVQSLQDELQKFLRDHLEFEAWLLQAEQELDRMHHGD
GG-LEALRPMLHRQSSFSEDVISHKG-DLRFVTMSGQKVLDAEK--ATAGPEVS---STG
ALVTSKLEDATKRYGTLHSKCAALGSHLNLLLDR

PF00435 // ENSGT00760000119163_1_Domain_25 (4535, 4646)

SQQFQDIANSLQTWLQRSEAAVSNLL
SEPISSDPAILQKQLASA-K--RLQEDLAEHQVPVEKLEKASRSLLEIHQAPVPDHKSIQ
E-TTASVMSRFQGLWGRMAERSDLLQKAIAQSQSVQEGLEGLARSMAHIEESLQRQEGTP
FSAAAVQEALANNTKLKQDLDRQRSLLEATQGMVARFAEAAESGAAAAALRSQLDSLTER
FGSLCQRRQKEEETLKELLPKVEQHEQLSQALEQFTETRGRMLAAGNQPHHDIGHFSQQI
QGCRCS------------------QECGYTFSLSKSDIF--------TPP-RLHLHCRVN
AESCKDVAQGMPGCFDVFTILMGGFSH--------VPTAMEMIDRIEITVFIFHPSHPEG
HSG-----RITLYTY----KANIQC---------YNIEQRQRQTQRVCLI---PAAGGAA
ALCNGQGLYF----IFNCQVLTP--T---WAGLLVRV-IYCSWLLTSLLTSLRHSTISFC
WMRAANALFNVPKLTFSLS-FVAFFFPSSFSQVFLTELEQNSVKVQKAKESLSGLLQKYP
DSPEAGNWKRTLEDLDSRWERANQVTTERQQKLEKSARELASFQVAEG

PF00435 // ENSGT00760000119163_1_Domain_29 (5149, 5244)

QLRPWLTEKELM
MSVLGPLSIDPNMLSAQKQQVQFMLKEFESRKPQFDQLNAAAQGMLTGPE-ASPSAGHMQ
DDLQAINQTWTALTERLDSRSAQIDQAMVKSTQFQALLQSLSEKVKAAGQRLSPQLAAST
QPEAVKRQLEEASEVRSDLEQLENNMSEAQALCEELSVLIGEQYLKDELKKRMEAVALPL
RGLQDL------AADRMNRLQTALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

SQQFQQMFDELQVWLDEKVRCQAQAGPISAKLER
LQTQIQEQEELQKSLNQHSGSYEMIVAEGESLLVSARAGEEKARLQGQLTNLKARWEELS
KQAADRHAKL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCLQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQRHVEDLFPWVEDCRSKVTELEVTLDPVQLEATLLRSKAM
LSDVEKRRSLLEMLNSAADVLINASEMDEDDVRDEKAGINQKMDAITEELQAKAGSLEEM
SQRLKEFQESLRNIEKKLEGTKHQLEIYETLGPQACSNKNLEKLRSQQEALRALAPQVDY
LKNFTRGLVEDAPDGSDSSHLLRQAEAAQREFEEVGQKVSECCTLMESKLEGIGQFSNHV
REMFSQLADLDDELDGMSPVGRDLDSLQSQAEDMHDFLGKLQRLKQDIQASEEKCREMLD
DEGSPDLVGLRRELETIHKQCGKLADRGRGRLEQVEAALS

PF00435 // ENSGT00760000119163_1_Domain_34 (5801, 5908)

RLRDFYGKLRELTAMAATAE
ESEALQWVVGTEVEAINQQLADFKLFQKEQVDPIQLKLQEVNGIGQGLIQSAGKNSDVQG
LEHDMEDINARWNTLNKKVAHRTAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6013)

KFQDALEPLLSWLTDTEELISNQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIHAEGGRIAQSAEPADREKIAAQLESLG
GRWEGLLSKAMAR-----------------------------------------------
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-----

------------------------------------------------------------
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------------------------------------------------------------
-------------------MCVPN-VK---ATHLLVV--SWLWLFEACCERSGESPCPLL
LWEPVTWVALSQYLLCVFFTDERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQEE
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKAPYS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHLLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLIQTWNLEKLRSSAP
GECHQIMKNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKAHFQHLMKSMENE
DKEETVAKMYISELKNIWLRLEEYEQRVVKRIQSLASSRTDKDARQDSALRIAEQEHTQE
DLQQLRSELDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEAVLADLSALEAHRSTLRHWFSDVKDKNSVFSVLDE
EIAKAKAVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVF-AQLEIRQSELESIQEVLG
DYQACHRTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSLGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-QTKES
TDIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQVNALNQA
YHDLCDGSANQLQQLQSQLAHQTEQKDCRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1904)

VLLESQVIMSGLIAPETGENLSLEEGLARNLINPQMYQE

ENSGT00760000119163_1_Linker_7_8 (1904, 1947)

LRELQDALALISG-LTE
SRG---PLSVMEAIEKRIISERVGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1985)

ILEAHLATGGFSLSPSENCINLEEAFHQGLISAW
LHSVLESHLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2096)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2102)

ACGIL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSNRQHIKALFLPATTEIFSWKKAIESGILDRDLANNLKSICIPD
VMPHMQLADS---AEQNINPGAAVL---PCTKSQP-----KT-IASKSEN-LLFQLMTHS
YINVQNGQRLLLLDKELMGILT--SRDEYQ-TSPP---EVVEIGHQRQKTPEGLQE--SA
NVKISGT-FSDGWTVRLPEFQFSSQNKEYPNQEDCTTEKGKKTTVETEDSS--------V
ENPEEDLFVEQ-KERNSNVDSLK-VINKVELEVQRQLIDTKREDQIAVSIKEN-----AS
RGHLLTVP-SAEAEGVLLVVDKDLFSVETPKKEHQ--PLRNTSFTCQNEQA--HTLETEY
IHDETGGSH---IKPQSKKSEVQVK-KTLGVKLELKSETDVNIHPLDKKQMLKKTFV---
----AKDD--HKESQEAQNIA-GGSMMMLEKTDEEDNGRETFLSYS----HPSELLEEAT
LNV

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2721)

LMEKLNMFQGFFDSQTCESL
TTEEVINEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGILDPRTHTLCSVKDAVTIGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDIADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEKEEAIRLLTKQVLDGGIIHHISGMRLSVDNAFRHGLIGEDLAQKLKRVENLNIHQIFNPETKETVSLPKAIKLDLITPDLNREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTVSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLAEAIEKRLISPELANMIQIDTSEFSNHR-AQIEKQEG-IEVCALQNESLRKDMLIACNQTAEMSC--NKVEESERLLQVENQSAQEKVKVRVSDRE-------QAKKSREISLKEFGCKDQHKPRMSPD---AKEFISIINPHNLKGKSL--GQVSLTHTY--SEVCDFKLKEVARNNMGNDTN----EEQKKAVTKIEIISHMKQS-PSCLDSEEIRENRGEVIL-EVQE-TYCETS------GKLPSKQVLQQPMNA--GVKSKREKREVIVEESIRTFKSAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEA-DTEKGFSVIFKIEDSSS-QVVPQGISVKHLDALTLFSSKQA----SEGKVN-----------NLSLCLTLKPEENLSQEIACGAQS-EPFPSMTPRP-EGLHYQESDGKTQVTGSSQISK-TDKPFQGTTRQETSYHQD-SCVTSKTKETK--HLISS---S-NE-CKEKS-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLEFSDRKDLHHQGSKSDDKLCGTLKSE-I--ATQEITGEKFLEMANPN-ITGLQA--GSIEDIVTQRGSRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVPETSEEKT-MSLTVC-STVKTE--------------KTPQEKLGESPGI---------EQ------TPFVTALGGKGNGGL--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTRQIQPL----ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNTILILNSKASNSE--T-DVDSLNRCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSPQQNRQMLRLLNELQRSFQEILEQTAAQVDALQGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFAAVVKDIEGFMEENQTKLSPHELTALREKLHQAKEQYEVLREQTRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSRAS--LEKGTLDTTDGY-MGVNQAPEKLDKHCEKMKARHQELLSQQQHFIMATQSAQAFLDQHGHNLTPEEQQMLQEKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHREFESWLERSEKELENMHKGGSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFKEGKEPS---EIGNLVKDKLKDATERYTALHSECTRLGSHLNMLLGQYHQFQNSADSLQAWMQTCEANVGKLLSDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQE-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLSQSIGEVEQNLEGKQVASLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITRFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL------K-------------DGTNLPPIPCKIPSVLSLIRNHPASAYTSNLSSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAVLNRMEEVQKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNRAFLAELEQNSPKIQKVKEALTGLLVTYPNSQEAENWKKIEEELNSRWERATEVTVARQRQLEESAGHLACFQAAESQLRPWMMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSTQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELKTWLDDKQSQQAKNCPISAKLERLHSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEERRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKVSELRVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAIIEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEVECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLKSLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVYQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQQKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALITQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNSEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKHRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIIHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQSMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTL-QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAREETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDTQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPSPEVISSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
RQVVTGGIIDLKRGKKVSVTLASTLGLVDIADQPELINLEKASKGRDAEKTVRERLISLQ
METTGLIDPDSKAPLTVVQSIDRGLLEKEEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLTKQVLDGGIIHHISGMRLSVDNAFR
HGLIGEDLAQKLKRVENLNIHQIFNPETKETVSLPKAIKLDLITPDLNREIQEVQAFTGN
FVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDKVLTVSQAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANTGGIIDTATG
KRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLAEAIEKRLISPE
LANMIQIDTSEFSNHR-AQIEKQEG-IEVCALQNESLRKDMLIACNQTAEMSC--NKVEE
SERLLQVENQSAQEKVKVRVSDRE-------QAKKSREISLKEFGCKDQHKPRMSPD---
AKEFISIINPHNLKGKSL--GQVSLTHTY--SEVCDFKLKEVARNNMGNDTN----EEQK
KAVTKIEIISHMKQS-PSCLDSEEIRENRGEVIL-EVQE-TYCETS------GKLPSKQV
LQQPMNA--GVKSKREKREVIVEESIRTFKSAFLSEEKLYQETAIRDEHDSHIKSQPREM
TSSEKGKEA-DTEKGFSVIFKIEDSSS-QVVPQGISVKHLDALTLFSSKQA----SEGKV
N-----------NLSLCLTLKPEENLSQEIACGAQS-EPFPSMTPRP-EGLHYQESDGKT
QVTGSSQISK-TDKPFQGTTRQETSYHQD-SCVTSKTKETK--HLISS---S-NE-CKEK
S-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLEFSDRKD
LHHQGSKSDDKLCGTLKSE-I--ATQEITGEKFLEMANPN-ITGLQA--GSIEDIVTQRG
SRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVPETSEEKT-MSLTVC-STVK
TE--------------KTPQEKLGESPGI---------EQ------TPFVTALGGKGNGG
L--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTRQIQPL--
--ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNTILILNS
KASNSE--T-DVDSLNRCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQEILEQTAAQVDALQGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFAAVVKDIEGFMEEN
QTKLSPHELTALREKLHQAKEQYEVLREQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSRAS--LEKGTLDTTD
GY-MGVNQAPEKLDKHCEKMKARHQELLSQQQHFIMATQSAQAFLDQHGHNLTPEEQQML
QEKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSECTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVGKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLSQSIGEVEQNLEGKQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITRFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL-----
-K-------------DGTNLPPIPCKIPSVLSLIRNHPASAYTSNLSSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAVLN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNRAFLAELEQNSPKIQKVKEALTGLLVTYP
NSQEAENWKKIEEELNSRWERATEVTVARQRQLEESAGHLACFQAAESQLRPWMMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSTQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELKTWLDDKQSQQAKNCPISAKLER
LHSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEERRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKVSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAIIEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEVECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLKSLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6128)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVYQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQQKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LITQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNSEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKHRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIIHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQSMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAREE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYR-----------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLPSPEVISSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGVKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQVQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIRQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIKELYKLLEVWIEFGRIKLPQGYHPNHVEEEWGKLIVEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDEKYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFS
SLELVPPST-------LTTTHLKAEPLNKTTHS--------------SSTSWFRKPMTRT
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNGKEEEELACDWSDSNPNISAKKTYFSELTMELEGKQ-DVFRSLQDTAEV-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENAAYFQFFSDARDLESFLRNL
QDSIKRKYTCDRSTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRNP
DHVLKSTLSVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKEAIEMASRVEQSYQKVMALWHQLHINTKSLISWNYLRKDLDTVQTWSLEKLRSLAP
GECHQVMKNLQA----HYEDFLQDSHDSALFSVADRLRIEEEVEACKAHFQHLMKSLENE
DKEETLAKVYISELKNIRLLLEECEQRLLKQIQSPASSKTDRDARQDITLRIAEQEHTQE
DLQHLRSDLDAISMKCNVFLQQSPSGSSATTLRSELNLMVEKMDHVYGLSTVYLNKLKTI
DVIVRSMQDAELLVKGYEIKLSQEEAVPADLSALESHRTTLQHWLSDVKDKNSVFSVLDE
EITKAKKVAEQLRHPASEPNLDLERYQEKGSQLQERWHRVI-AQLETRQSEVESIQEVLR
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTELFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMISSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKDLLGWVSTLARNTQGTTTSS-HTSAS
ADIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEGEKEQISEQLRVLNKT
YHDLCDGSANQLQQLQSELAQQTEQKGCRA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1905)

VLLESQIIMSGLIDPENSEKLSLEEGLTRNFINLPIYQQLLGLRDSLSLVSR-LTG
TLG---SLSVVEAIEKKIISERLGLKVLEVHLATGGFSLPPSENCINLEEAFHQGFIASS
LHSELQSHLRSSKNLIDPNTAEKVGLLDLMQRCIIHQESGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2102)

IL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGDRMTIDEAVTNNLVAAKIALVILESLWSFMGLLLPESGEILPITD
ALEQGIVSTELAHKILHNRQQIEALFLPTLTEIWSWEKATESGILDKDLVNNLRSVCIPD
MMPHIQLADSAEQSKVGFAAGKPPV---SGPR--------EE-GSSHGEK-LLFQLMTHS
YIHAHTGQRLLLLDQELVEMLT--SRDDCQ-VILP---EVFEIQHQRLNTSEALQE--LY
TGTISQI-SSAKHPRKPCESQFLSQNKDYPSQENCTEAKGERSVVGIECSP--------A
ESPERELFLKEQEAIIENVGSLK-VINKVKLKLQRPLLGSRKEEQAETLREEN-----IS
GDPLLVEC-PEESEGKD---------LSTEKSKCQTP--TKCSFTCHKEQV--KTIK--D
IPSETGTSL---IKSQNQMSQFQVD-TSVGLRSEFKSEHDMNVNSLEKELKEELLV----
-----KDG--HKQSQEGQSVA-DGQTVALEKTDTEDNADEPALLHS----SPFE---DAT
LST

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLQDGGIFNEETGQKLLLNEAIAQGLVSSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2726)

LMGKLNMFRGFFDSQTCESL
TTEEVIDEGLMDEKLL-YNVLMSDK

PF00681 // ENSGT00760000119163_1_Domain_14 (2726, 2757)

AISGILDPRTHSLCSVKEAVAAGLLDKETAT

ENSGT00760000119163_1_Linker_14_15 (2757, 2757)

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2790)

RILE
GQVITGGIVDLKRGKKLSVTLASNLGLVDTADQTELINLEKATKGRGAEKAVKERLIELQ
METAGLMDPESKAPLTVLQSIDRGILEREAAVY

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2892)

LLTKQVLDGGIIHHISGLRLSVDNAFK
HGLIGEDMARQLRKVENFIHYQFFHPQTKEALSFSEAIKLDLVSPDLKREIQEIQDFSGN
LGDFIYGQKLTLAKTNKEESLA----NKTELPSGVMHGVIDPENCTIIPYSELVKKCRID
TESGWRYLEVIPFSDIKDEAGNNVLTPPEAIQLGKVDFASALK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3081)

VLEAQANTGGIIDMATG
KRVTLASALEKKLLDENMARIIAS-----HQMLSGGIIDIYSDQRVTLNDAVEKRLISPE
LAAMIQVDPLAE-----------QGGTGVCELKGDFLRKELLSESSKTPRESY--SKEKH
EAVL-QAGSLCAPEKAGIRGSNGE-------KAEKGRKISV-EMEGQRQDE-KASSD---
NKVSASILSPFGFEGESS--YQVSVTHPC--SESCDLKPREETRSCMKKCAV----VERD
KVVTQIKMVSHVKQS-TSGLDAEEARERQGRMVS-KEQG-SHYETA------GNLLSERS
V--RVDR--RVR--REMG-GEQSVQMSREAA-VLSEEELDQEVTIGDEPDSFVKSQSMKM
IGNDKGKEA-GIEKDISVVCKIEGFPS-QMTSKDASLTNQDALPF-----Y----TEGET
K-----------TVNLCSILKPGEKLSQETASTVQK-EPLSSEIPRP-ERLNSQESDEEP
QISDVPHISK-GDMAAQITTRQETTDVQD-LYITSKSSETK--DKIFP---S-KN-YIEK
L-HQEIPMDPTRS-------------------HKL-KE-ATISTLETEGISYLDSSDIKS
LCEDSKADHK-SCGHQKS-----KVTTTQAKKSLEVVDLL-VRDTEE--GSSEDRVGQRG
PRVLASLLPEKLP--TRTV----QSENIRQHDAV-I-PAISEIREEMA-LSLP-CSVVKV
DG--------------KIPKEKHKEILGD---------EQ------GPFMAIPSGKGIEG
V--NPEPC---RATQNVFT--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQPL--
--ELNVAELQDLLGQAKELDRELKDLSTVVSQELECVDRIVISQPQEVPAQLLKALEKDA
KNLQKSLDSVSDSWSSRFLHLQSAV-EVKKATVLNRHKELQGKLQDLRAWVGRASLTLNS
KGCDTE--T-DADSLSHTLQPYKDMKQSMAERKSQLDALALDIQLFISEHPQDLSLQQNQ
EMLQFLSELQRSFQGLVEHTAAQKDVVQGHLQQVQQEVQVK-TLQKQQDTCHKKLEDLCN
WVGQAERALERHQ-GGASRQELPALQQNQSDLKDLQGDIQSHSTSFATAVKDIEGFLEEN
QTKLSPQELTALREKLHQAKEQYEVLQERTRVAQKELEEAVTSALQQETEKSKAATELAE
NKRKIDALLDWVASVG----------S--SERKPQASLPGMEQFSGAC--LEKQTLAATD
GH-VDVNQVPETLDRQYELMKARHQELLSQQQNFIVATQSVQSFLDQHSHNLTPEERQKL
QEKLGELKEQYAASLARSEAELKQTQALRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4489)

ELQKFLQDHKEFENWLQQSENELDSMHKGG
SS-PEALNSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLET-ENNFE

ENSGT00760000119163_1_Linker_24_25 (4489, 4534)

EGQEPS---ATR
NLVNEKLKDATERYTTLHSKCIRLGSHLSMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQAWVLTCEASVGKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKAAHDLLDIEGEPALDCRPIQ
E-TTDSISSRFQNLSCSLDERSALLQKAIAQSQSVQESMESLLQSIREVEQNLERDQVAS
LSSGVIQEALANNMKLKQDIARQKSSLEATHDMVTRFMETADSNS-ASVLQGKLAELSQR
FQQLQLQQQEKESNLKKLLPQAEMFEQLSNKLQQFMENKSRLLASGNQPDQDIAHFSQQI
QELTLAMEDQKENLDTLEHLVTTLGSCGFALDLSQHQDKIQNLKKDFTELQKTVQEREKD
ASTCQEQ-------LDEFRKLIRTFQKWLKETEGNVPPAKTFVSAKELEKQIEHL-----
-KD-----LISDWESKGALLGEINAKGTALESLIMDITAPDSQAKTGSIL---PPVGSSV
GSVNGYHTCK-DLTEIQCDMFDVNSKYEKLWEVLRERQESLQTVFS

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEASSVLQ
WLESKEEVLKAMDATLSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLKTYP
NSQEAENWKKMQEDLNSRWEKATEVTVARQKQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDMSPSASQVH
KDLQSISQKWVELTDKLNSRSSQIDQAIVKSTQYQDLLQDLSEKVKAIGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLGQLDNEIKEAQTLCQELSLLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDEKQSQQAKNCPISAKLER
LQCQLQENEEFQKNLNQHSGSYEVIVAEGEALLLSVPPGEEKKTLQNQLVELRSHWEDLS
KKTANRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQGHVEDLVPWIDECKSKMSELQVTLDPVQLESSLLRSKAM
LNEAEKRRSLLEILNSAADILINSSEIDEDEIRDEKAGLNQNMDAITEELQAKTSSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLKAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASPLVHQAEVAQQEFLEVKQRVSSSCLTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQALRFDIEDSEAECRKMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKVRQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKALNDAATAAE
EGEALQWIVGTEVDVINQQLADFKLFQKDQVDPLQVKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMDEINTRWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLTDTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
RRWTDLLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6225)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIHQ
QIIRHK------------------------------------------------------
-------------------------------------------------------ALNEE
IINRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITLTSSKALRTLEQARQ
LATKFHSTYEELTGWLREAEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSHALLELVPWRAREGLDKLVSDANEQYKLISDTVGQRVDEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFST
CGEEQKAVLQEKTECLIQQYEAVSLLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWAEETLA
LIAQLPPPAVDHEQLRQQQE-EMRQLRESIAEHKPHIDKILKIGPQLKELNPEEGKMVEE
KYQKAENMYAQIKDEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARSEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVATVNKAGSELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELNRMENQLSASKPTGGLPETAREQLDTHMELHSQLRAKEE
IYNQLLDKGRLMLLSRGDSGSGSKTEQSVALLEQKWHAVSSKVEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7137)

EALSL

PF00435 // ENSGT00760000119163_1_Domain_47 (7137, 7240)

ATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNDHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLA
GDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEGSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNTAVAMGEAILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALITEHQSFMEEMTRKQPDVDRVTKTYKRKSVEPTHAPFMEKSRSGSR---KSLNQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLE------ELCPELKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7943)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKV-------------------------
------------ISSSGSKLKRPTPAFHSSRTSLAGDTSNSSSPASTGAKANRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQEE
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSQVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKAPYS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFRT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHLLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLIQTWNLEKLRSSAP
GECHQIMKNLQA----HCEDFLQDSRDSVLFSVADRLRLEEEVEACKAHFQHLMKSMENE
DKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDARQDSALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIVRSIQDAELLVKGYEIKLSQEEAVLADLSALEAHRSTLRHWFSDVKDKNAVFSVLDE
EIDKAKAVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-QTKES
TDIEKAILEQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNQA
YHDLCDGSANQLQQLQSQLAHQTEQKDCRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGLA

PF00681 // ENSGT00760000119163_1_Domain_7 (1866, 1904)

LLESQVIMSGLIAPETGENLSLEEGLARNLINPQMYQE

ENSGT00760000119163_1_Linker_7_8 (1904, 1947)

LRELQDALALISR-LTE
SRG---PLSVVEAIEKRIISERVGLK

PF00681 // ENSGT00760000119163_1_Domain_8 (1947, 1985)

ILEAHLATGGFSLSPSENCINLEEAFHQGLISAW
LHSVLESHLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2096)

RLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2102)

ACGIL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGQRLTINEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD
VMPHMQLADS---AEQNINHGAAVL---PCSKSQP-----KA-IASKSEN-LLFQLMTHS
YINVQNGQRLLLLDKELMEILT--SRDKYQ-TSPP---EVVEIGHQKQKTPEGLQE--SA
NVKISGT-FSDGWTVRLPEFQFSSQNKEYPNQEDCTTEKGKKTTVETEDSS--------V
ENPEEDLFVEQ-KERNSNVDSLK-VINKVKLEVQRQLIDTTREDQTAVSIKEN-----AS
RGHLLTVP-PAEAEGVPLVVDKDLFSVETPKKEHQ--PLRNTSFTCQNEQA--HTLETEY
IHDETGGSH---IKPQSKKSEVQVK-KTLGVKLELKSETDVNIHPLDKKQMLKKTFL---
----AKDD--HKETQEAQNIA-GGSMMILEKTNEEDNGRETFLSYS----HPSELLEEAT
LNV

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2721)

LMEKLNMFQGFFDSQTCESL
TTEEVINEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGILDPRTHTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDIADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAIRLLTKQVLDGGIIHHISGMRLSVDNAFRHGLIGEDLAKKLKRVENLNIHQIFNPETKETVSLPKAIKLDLITPDLKREIQEVQAFSGNFVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEELVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLAEAIEKRLISPELANMIQIDTSEFSDHR-AQIEKQEG-IEVCALQNESLRKDMLIACNQTAEMSC--NKVEESERLLQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFRCKDQHKPRMSPD---AKEFISIINPHNLKGESL--GQVSLTHTY--SEVCDFKLKEVARNNMGNDTN----EEQEKAETKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQVLQQPMNA--GVKSKREKREVIVEESIRTCKSAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEA-DTEKGFSVIFKTEDSSS-QVVPQGISVKHLDALTLFSSKQA----SEGKVN-----------NLSLCLTLKPEENLSQEIACGAQS-EPFPSMTPRP-EGLHYQESDGKAQVTGSSQISK-TDRSFQGTTRRETNYHQD-SCVTSKTKETK--HLISS---S-NE-CKEKS-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLEFSDRRDLHHQGSKSDDKLCGTLKSE-I--ATQEITGEKFLEMANPN-VTGLQA--GSIEDIVTQRGSRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVPETSEEKT-MSLTVC-STVKTE--------------KTPQEKVRESPGI---------EQ------TPFMTALGGKGNGGV--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTRQMQPL----ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNTVLILNSKGSNSE--T-DVDSLNRCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSPQQNRQMLRLLNELQRSFQEILEQTAAQVDALKGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFAAVVKDIEGFMEENQTKLSPHELTALREKLHQAKEQYEALREQTRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSKAS--LEKGTLDTTDGY-MGVNQAPEKLDKHCEKMKARHQELLSQQQHFILATQSAQAFLDQHGHNLTPEEQQMLQEKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHREFESWLERSEKELENMHKGGSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFKEGKEPS---EIGNLVKDKLKDATERYTALHSECTRLGFHLNMLLGQYHQFQNSADSLQAWMQTCEANVGKLLSDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQE-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLSQSIGEVEQNLEGKQVASLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITRFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELENQIEHL------KS-----LLDDWASKGTLVEEINCKGTPLENLIMEITAPDSQGKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGILHERQESLQAILNRMEEVQKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIEEELNSRWERATEVTVARQRQLEESAGHLASFQAAESQLRPWMMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSTQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLHSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAVGRDTDSLQSQIEDVRLFLNKIQVVKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLKSLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQSMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTL-QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAREETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHAVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDTQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWTKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPSPEVISSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
RQVVTGGIIDLKRGKKVSVTLASTLGLVDIADQPELINLEKASKGRDAEKTVRERLISLQ
METTGLIDPDSKAPLTVVQSIDRGLLEREEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLTKQVLDGGIIHHISGMRLSVDNAFR
HGLIGEDLAKKLKRVENLNIHQIFNPETKETVSLPKAIKLDLITPDLKREIQEVQAFSGN
FVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANTGGIIDTATG
KRLTLASALEEELVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLAEAIEKRLISPE
LANMIQIDTSEFSDHR-AQIEKQEG-IEVCALQNESLRKDMLIACNQTAEMSC--NKVEE
SERLLQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFRCKDQHKPRMSPD---
AKEFISIINPHNLKGESL--GQVSLTHTY--SEVCDFKLKEVARNNMGNDTN----EEQE
KAETKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQV
LQQPMNA--GVKSKREKREVIVEESIRTCKSAFLSEEKLYQETAIRDEHDSHIKSQPREM
TSSEKGKEA-DTEKGFSVIFKTEDSSS-QVVPQGISVKHLDALTLFSSKQA----SEGKV
N-----------NLSLCLTLKPEENLSQEIACGAQS-EPFPSMTPRP-EGLHYQESDGKA
QVTGSSQISK-TDRSFQGTTRRETNYHQD-SCVTSKTKETK--HLISS---S-NE-CKEK
S-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLEFSDRRD
LHHQGSKSDDKLCGTLKSE-I--ATQEITGEKFLEMANPN-VTGLQA--GSIEDIVTQRG
SRVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVPETSEEKT-MSLTVC-STVK
TE--------------KTPQEKVRESPGI---------EQ------TPFMTALGGKGNGG
V--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTRQMQPL--
--ELNLAELQDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNTVLILNS
KGSNSE--T-DVDSLNRCLQQYEDLKQPMAERKSQLDALAFDVQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQEILEQTAAQVDALKGHLQQMEQEALVK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTRQDLSALQKNQSDLKDLQDDIQNHATSFAAVVKDIEGFMEEN
QTKLSPHELTALREKLHQAKEQYEALREQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSKAS--LEKGTLDTTD
GY-MGVNQAPEKLDKHCEKMKARHQELLSQQQHFILATQSAQAFLDQHGHNLTPEEQQML
QEKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSECTRLGFHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVGKLL
SDTVASDPGVLQQQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHKHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLSQSIGEVEQNLEGKQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITRFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELENQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTPLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGILHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVQKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIEEELNSRWERATEVTVARQRQLEESAGHLASFQAAESQLRPWMMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSTQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LHSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVTQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAVGRDTDSLQSQIEDVRLFLNKIQVVKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLKSLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6128)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLEQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETRA
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQSMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAREE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHAVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWTKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR---KSLSQPT
PPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLPSPEVISSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

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----------------------------------------------------MQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLEAQVIMSGLNVPETNEKLSLKEALSRNLIDQQTCLLLQEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

EDAQSSINM-LSE
GKD---YLPVVEAMEKGQVSERVG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

MKILEVHLATENFPFSPTEKQINLKEASYQGLTTAQ
LHSKIETHLRSCKNLIDPNTAEKISLLDLMQRCIVHQDSGLRLLPIKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIVDPRTGHRLTVDEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CAIL
IRQLQTGGIIDTVTGFRLTVDEAIRKDLIASKMALVILQS

ENSGT00760000119163_1_Linker_11_12 (2141, 2146)

LWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2179)

GLLWPESGEILSIAD
ALEQGILSTELAHEILGN

ENSGT00760000119163_1_Linker_12_13 (2179, 2641)

RQYIKALFQPATTEVWSWKEAVDKGILDEDIAKNLKSTCIPD
VMPSMQLAGFLERSALGISSMAAAP---LY--SED-----RC-ICTKNEK-LLFHLMTHS
YIDVHSGHRLLLLDEGLVEILT--PREKHH-AYPL---EACEVSQPSPEAHREIRD--LA
SVR-HPE-IDRGWTVRHKELQVALKEESPKEQ---PTDENKKKILEVRPST--------S
KESGKNSFPENQEMGIPNPGGLKNIINTESEQQSQNSIVKKEEPKELYSNEEF-----VG
IQILVDED-PLSAEPIRKNKTTLTETVSALQHEQGII-------SWTEKEA--H------
VPGRIGRDL---VKPQSKQLESQEE-RTLHSESDMRPSNIKTFHLLGKERTVSKLVK---
----EKDD--QKQSLERGKMA-SESLIKMVKRDMESMSVDSVMEMSPLLDHPLESSEDAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2685)

LKMLSTQLEYGGILHDETGQKLLLNEAVACGIVPSHTAVKLMEK

ENSGT00760000119163_1_Linker_13_14 (2685, 2718)

LKMFRGFFDSQTCESL
TTEEVIDEGLMNENLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2762)

QKVFTSDKTISGVLDPYTNTIRSVRDAVRVGLLDKQTATRILE
G

ENSGT00760000119163_1_Linker_14_15 (2762, 2763)

Q

PF00681 // ENSGT00760000119163_1_Domain_15 (2763, 2800)

VVTGGIVDLKRNKKVSVTLASNLGLVDSADQRELICLEKATKGKESEKIAKQKLISLQ
VETNGIMDPDTKIPLTIVQSINKGLLEREEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

IQLLTKQLVDGGIIHHSSGMRLSVDNATE
RGLIDGDLSKELKQV

ENSGT00760000119163_1_Linker_17_19 (2896, 2933)

ENICLHRFIHPKTKAFISLPEAIAIDLVTGDFTNQVQ

PF00681 // ENSGT00760000119163_1_Domain_19 (2933, 2974)

EIQALSGN
FIDPISGQRLSLSEAVRIGLSS----NEVTLSS

ENSGT00760000119163_1_Linker_19_20 (2974, 3042)

GVIHGIVDPENCKIVPYSELIKKCKID
VESGQRYLEIIPFSDVR-GVAGKQLTLSEAVQLGKVDLVPM

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3091)

LRLLKAQADAGGILDIATG
KKLSLKSALEQKLVDEKMVRVIAT-----HQVLNGGIVDVSSDQRVTLIEAVERGLIHSE
LLASIQTDIXXXX------YAQATE-VSYYENQEETEKNAMDEKTKVRVPEGE--QRRKS
RKLL-SEGYKSVDQGERITPHDAI-------GSTKITLSPNFE-----------------
-DSFLDQIVVKQP-HSEG--YSSGVKQIK--IKSPDIKDESGVWRNTKRENR----HVKK
SCSSRNNPTYEGRQT----------LEDKLSLTS-ETQE-PKCETL------GKLLTDLS
MKKPVTT--DIER-EKEKELNAKESGLSYTLVPITEAKFSQEMIAKDEQDSQENLQTKEE
TVQEREKES-YVNQKLTNI---------KITPQVIFTENRGTQDV---------------
--------------DTFLTFRPAKSLQ-------------------N-PSVSFGDKKCE-
---------------------------------------------ISS---S-DA-PKEK
S-HQGVTCDSLMS-------------------LKI-EE-VTVSGASIQGTQGLGFPEKSI
LLQEDSRNNEELGRIFKSEQI--RGQEIIGEKISHLASSI-VANPET--VLLEETVTRN-
PRSSVHFTPEKPL--QDMSREAVREPQITDTPRF-KCRSGAKSDGEKP-VPLASAQEGKL
DE--------------KTGQEKVILSSSS---------EQ------SLFGTLPEGKGNED
T--GQQPF---KTAKTVYS--------RRLCLEHDEQLVSYLSLLRNIEMRTKQICSA--
--ELSLAGLQDQLRQAKILDRELRDLSILVNRELECVNQIVAKQPQEVPAQLLKALEKDA
KNLQKSFRSVSDTWASRLLSLQNSV-DVEKVKIL

PF00435 // ENSGT00760000119163_1_Domain_22 (3995, 4109)

NQHEVLQDKLQELGTWINETSHFLYH
RENVNE--S-DAADLNNHLQEYEALKQPFSERRSQLDVLALDIQYFISEHAQDLAPPQSL
KLLRLLNELQKAFHELSVHAMAQKDALQ

ENSGT00760000119163_1_Linker_22_23 (4109, 4126)

DHLQRVMQAAQVQ-TLQ

PF00435 // ENSGT00760000119163_1_Domain_23 (4126, 4228)

EQQNTCHQRLEDLCA
WVSQADRALTGHHIRGGSPEDLSTLQQKQDSVKDLQKDVQNHATSFANVIKDTEGFLEEN
ETKLSPHELSSLREKLRQAKEQSEALQ

ENSGT00760000119163_1_Linker_23_24 (4228, 4410)

ERTRMAQKELKEAVTEALKQESEKTKAAKELEE
NRSKIDALLDWVASLE----------S--TGGLSKANFPKLEHTTGES--LGNGVMDTID
GY-AEMSQAPEKLDHQYEGAKARHQELLSQQQDFILATQAAQAFLDKHGHSLALEERQKL
QQKLRDLKEQYAASLARAEMEVKQSQALR

PF00435 // ENSGT00760000119163_1_Domain_24 (4410, 4519)

DELRKFLRDHGEFEDWLQQAEKELENVHKGG
SD-PEALQSLLLRQKSFSEDVISHKG-DLRFVTMSGQKVLDT-ENSSREGTEPS---ATR
HLVTSKLDNATERYTALHLKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXXXXXXXXXXXXXMEGEPAPDPRHIQ
E-TTDSILGHFQSLSGRLEERADLLQKAI

PF00435 // ENSGT00760000119163_1_Domain_26 (4650, 4757)

AQSQSVQEGLENLLQSISEVEKSLEGEQVAA
LSSAALQEALAINMKLKQDIARQKSSLEATREMVTRFMETADGTT-ATGLQGKLAEVTEC
FSQLCQRQQEKESSLK

ENSGT00760000119163_1_Linker_26_27 (4757, 4866)

KLLPQVEMFEHLSEKLQQFLDSRARVLASGNQPDRDITQFSQQI
QELNLEMGEQQENLDALEHLVTGLSSCGFALDASQHQERVQKLKKDFTRLQKSVQEREKD
TSSCQ

PF00435 // ENSGT00760000119163_1_Domain_27 (4866, 5023)

EQ-------LDEFRKLVQALQKWLKESEGNMPVVEISMSTKELQKQIEHL-----
-EA-----LLDDWTSKGPQVEEINHKGMALENLIVEITAPETQSKTGSVP---PSLGGSV
GSVNGYHTCK-DLTEIQCHMSDVSQQYEKLGGVLQERRDSLL

ENSGT00760000119163_1_Linker_27_28 (5023, 5026)

AML

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

NSMQEVQEEASSLLQ
WLESKEQALKALEASSSPTKTETVKAQAECNKAFLAELEQNSPKIHKVKEALADLLKKYP
NSQEAKHWKEMQEELSSRWERANEVTAARQQKLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5138)

ESA

PF00435 // ENSGT00760000119163_1_Domain_29 (5138, 5246)

NQLASFQTAEAQLRPWLMEKELM
MSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRPQHEQLNQAAQGILTGPGDVSPSTRQVQ
EELQSINHKWVELTDRLNSRSNQIDQALIKSTQYQKLLQNLSERVKAVGQRLNGQSAIST
QPVAVKQQLEETSEIRSDLEQLDHEITEAQTLCDELSTLIGEQYLKDELRKRLETVALPL
KGLEDL------AADRMNRLQTAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLDDKQSQQAKTHPISAKLDR
LHCQLQEQEEFQKSLNQRSGSYEVIVAEGESLLLSVHPGEEKRTLQSQLVDLKSHWEELT
KKAADRHSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCM

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVEDLVPWIEDCKAKMLDLQVTLDPVQLESHLLRSKAM
LTDVEKRRSLLEMLNSAADILINSSQTDEDDIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRLKEFQDSFKNIEKKLDGAKHQLEIFDALGPQACSNKNLEKLRAQQEVLQALEPQVDY
LKNFTQGLVEDAPQGSDASQLLCQAQVTEQDFMEVKERVNSSCMTMENKLEGIGQFHCRV
REMFSQLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQEAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEDLIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGERIAQSAELADREKITSQLENLG
RRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIVRHKALEEEIESRAADVQQAVRVGHSLSSLTCPAEQGILADRLEALQARYSEVQNWCC
RKAALLEQAV

PF00435 // ENSGT00760000119163_1_Domain_37 (6131, 6237)

ANARLFGEDEVEVLNWLAEAEDKLSSVFVKDYRQDVLQKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADLTVSSSKALRTLEQARQ
LATKFQATHEELTGWLSKVEEELMASGQSKGE----QQFQQRQKXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

XXXXXYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDPVDELFSQRSEIFGT
CGEEQKAALQEKTESLVQQYEAISQLNSERYARLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETYEELNPWIEETQT
LIAQLPPPAIDHEQLKQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPDEGEMVQE
KYQTAEETYSRIKEEVRRRALALDEAVSQSAQXXX-------XXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
IQDKLDQMVFFWEDIKARAEEREIKFLDVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSMDEMNNA
WENLNKTWRERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

EAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQTMFDWLDNTVIKLCNMPPVGTDLNTV
KEQLNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAGDDDASSLRNRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

STLQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLGLTRMENQLSSSKPTGGLPETAREQLNAHMELYDQLKAQEE
TYNQLLDKGRLILLSRDDSGSGSKTEQSVTLLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EVL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQNLNIAPPPSLILNTILSQIDEHKVFANEVNAHRDHIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAENHLDSELEISNDPDKIKLQLSRHK--EFQKTLGGKQPVYDTTIRTGRALKEKTSLS
DDAQKLDNCLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVRVQLQE
LSTRWDTVCKLSVSKQTRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

HAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FRNAVHLLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDVHKEFMKKVEEKRVDVNAAVAMGEAILAVCHPDCVTTIKHWITIIRAR
FEEV--LTWAKQHQQRLEAALSKLVANAELLEELLAWIQWAE-TTLIQRDQEPTPQNIDR
VKSLIAEHQXXXXXXXXXXXDVDRVTKTYKRKAIEPTHAPFIEKSRSNR----KSLGQAA
PPPMPLLSQSEAKNPRIHQLSARWQQVWLLALERQRKLNDMLDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7945)

DKIEDEXXXXXXXXXXXXXXXX
XXXXXXXXXFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNIELREKFILPEGVSQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCASMPSSPATPASGA---------------------------
----------KVMSSTGSKLKR--PAFHSSRTSLTGDASNSSSPVSTSAKTNRTXX----
----------------------------------------XXXXXXXXXXXXXXXXXXXX
XXXXXXXSDFD-VETQSAC-DTSESSAAGGQSSSRRGL--TKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------Q

PF00307 // ENSGT00760000119163_1_Domain_1 (396, 427)

VKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_1_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAF

ENSGT00760000119163_1_Linker_2_3 (544, 853)

PKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFS
SLELAPPST-------LTTTHLKAEPLTKGTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEG

PF00435 // ENSGT00760000119163_1_Domain_3 (853, 950)

NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKEMSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKKNYFSELTMQLEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAAQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKSTISVKAICDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
SPNKDAIEMATRVEQSYQKVMALWHQLHVNTKTLISWNYLRKDLDLVNTWNLEKLRSSAP
GECHQVMKNLQA----HCEDFLQDSRDSLLFSVADRLRLEEEVEACKTHFQHLMKSIENE
DKEETVAKMYISELKNIQLRLEECEQRLVKRIQSPASSRTDKDARQENALRIAEQERTQE
DLQQLRSEFDAVCTKCNSFLHQSPSGSSVPTLRSELNLLVEKMDCVYGLSTVYLNKLKTI
DVIVRSIQDAELLVKGYEIKLSQEEAVPADLSALESHRSTLRHWLSDVKDKNSVFSVLDE
EIAKAKVVAEQLSRLTPERNLDLERYQEKGSQLQDRWHRVI-VQLETRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTDLFAEIERNQTKLDQCQK
FSQQYSTIVKYYYFVTTTVCLFFRNRKYAGVARRSLPSMVHLSVEHFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLTK-------------ES
TDIEKAILDQQVLAEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKEQISEQLDALNKA
YHDLCDGSANQLQQLQSQLAQQTEQKGCRA--VAGVIDLGT--VEIFPIFKAMQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVIMSGLIAPETSEKLSLEEALARNLINPQMYQQFQEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

QDALSLISR-LTE
NKG---LLSVVEAIEKKMINERVG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1989)

LKVLEAHLATGGFSLPPNKSCINLEEAFHQGLISAR
LHSVLESYLKSSKNLIDPNTAEKVSLLDLMQRCIVHQDSGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVT

PF00681 // ENSGT00760000119163_1_Domain_10 (2059, 2096)

VRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDM

ENSGT00760000119163_1_Linker_10_11 (2096, 2097)

A

PF00681 // ENSGT00760000119163_1_Domain_11 (2097, 2141)

CAIL
IRQLQTGGIIDTVTGHRLTIDEAVSNDLVAAKIALVILES

ENSGT00760000119163_1_Linker_11_12 (2141, 2146)

LWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2179)

GLLWPESGEILPITD
ALEQGIVSTELAHKILSG

ENSGT00760000119163_1_Linker_12_13 (2179, 2641)

RQHIKALFLPASTEVWSWKKAVEDGMLDKDLVNNLKSVCIPD
VMPHMQLADSSERSKLNINPGAVGL---PRSQSQT-----EG-LVSPSEK-LLFQLMTHS
YIDVRDGQRLLLLDNELLETLT----AR----------EALEVGHQRLETPEELKE--SV
NVKSTET-FCDGLNVRPREFQVSFPNEEYPNRADCTEAKGKTTTVEIEASP--------M
ENPERDLFVGEQKVKVPDVDTLM-VPDKGKSELKGHLLGNKKEELTGISTREN-----IS
RGFLLTVP-TEEAEDMTLVVSKDPFPVETLKEEWQTP--GKTSFLCQTERA--DTLEIE-
IPGGTGSPL---IKPPSKKSQFQVK-KTLDLESELKSENDMNIHTLDKKKSLNKTFS---
----GRDD--HKQNPEGHDTV-GSSVITLEKTSVEDNDHETSLSCS----HPSELLQEAT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2710)

LNTLSAQLLDGGIIHEQTGQKLLLNE-----------------------------TCESL
TTEEVIDEG

ENSGT00760000119163_1_Linker_13_14 (2710, 2718)

LMDEKLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2762)

HNVLMADKAISGVLDPRTHTLCSVKEAVSVGLLDTQTASRILE
G

ENSGT00760000119163_1_Linker_14_15 (2762, 2763)

Q

PF00681 // ENSGT00760000119163_1_Domain_15 (2763, 2800)

VVTGGIVDLKRGKKVSVTLASNLGLVDSADQTELINLEKASKGRDAEKTVRERFVSLQ
METTGIMDPDSKTPLTVMQSIDRGLLEREEA

PF00681 // ENSGT00760000119163_1_Domain_17 (2852, 2896)

VRLLTKQVVDGGIIHHISGMRLSVDNAFE
HGIIDEDLAKQLKKV

ENSGT00760000119163_1_Linker_17_19 (2896, 2929)

ENLSLYQFFHPETKETITLPKAIKLDLVTPHLK

PF00681 // ENSGT00760000119163_1_Domain_19 (2929, 2974)

REIQEIQALTGC
FVDLISGQRLTLAEVEKEGLLT----NKAILSS

ENSGT00760000119163_1_Linker_19_20 (2974, 3042)

GMMHGIVDPENYRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDEASDKVLTLPQATQLGKVDFVST

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3109)

LKVLEAQANNGGIIDTATG
KRLTLASALEQKLVDENMVKIIAS-----H------------------

ENSGT00760000119163_1_Linker_20_22 (3109, 3995)

QEAVEKGFISPE
LATVIQADTLESCHHG-AQIEKQGG-IEVCETEKEFVRKEMLVACNRTAGMSY--GKGAS
EKLF-EIGSQSAQGKVKTRVSDRG-------QDKKS------------------------
-----SIIIPGDPEDTSL--GQGSVTLSH--SEVRDFKFKEATSDDVEKNTN----EARK
NTEAQMEITSHMKWS-ISSPAPKEIRESQESIIS-EGQESDYETC--------KLLSEQV
MQKPMTT--REKNKRENREMIIEESVKTCKP-VLSEEKLNPETTIRADQASNVEGPPVEI
TINEKGEEA-DRELGFSIVCQAENS-S-PMIPKGISV-TEDVLTFFKPNQV----SEGEV
K-----------NLSLSLTLKPEENLS-QITGGTQS-EPFSSITPRP-EGLYYQESVGKA
QVAGRSQISK-SNKPFQGTIRPETTSCQD-SCVTFKTKETK--DLICS---S-NE-YKER
S-YQEVPFDSTRT-------------------LKL-EE-TTVSTVEPKEVSYLEFSDRRD
FHHQDSKSDSEICGILTSK-I--IATQEMTGEQFLEMSDPRVTGVEA--VSSEGMVSQGV
PRVLASLPPEKLF--KDVS----PKESAGQQDAT-VSPTIPEISEEKP-VP--LIQPTVK
VD--------------KTPWEKLRESPRD---------EQ------TPFVTTAGGRGSEG
V--NSQPS---RTTKNVFN--------RQLCLEYDEKLVSYLSLLRDIEMRTKQIQPL--
--DVNLAELQDLLGQAKVLDRELKDLSTLVNQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWSSRLLHLQSAV-EVKKTRVL

PF00435 // ENSGT00760000119163_1_Domain_22 (3995, 4109)

SQHEQLEGRLQDLRAWVGSTNLLLSS
KEYNDE--T-NTDSLKHCLQQFEDLKQPMAGRKSQLDALAFDIQFFISEHAQDLSPQQNR
QLLRLLNELQRSFQDLVEQTTAQMDTLQ

ENSGT00760000119163_1_Linker_22_23 (4109, 4126)

GHFQQMEQAAQVK-TLQ

PF00435 // ENSGT00760000119163_1_Domain_23 (4126, 4239)

KQQNTCHQKLEDLCN
WLGQAESTLAGHQ-EAVEGR-VDLKKKTSKKRKDLQDDIQNRAASFASVVKDIEGFLEEN
QAKLSPHELTALRKKLHQAKEQYEALQERTRVAQKELE

ENSGT00760000119163_1_Linker_23_24 (4239, 4410)

EVVTSAVQQETEKSKAAKELAE
NRSKIDALLEWVTSVG----------L--SGG-------QMEQLSGAS--LGKEAFDTTD
AH-KGASQAPEELDKQCEKMKARHQELLSQQQNFILATQSAQAFLDQHGHSLTPEERQVL
QDKLGELKGQYAASLAQSEAELRQAQTLR

PF00435 // ENSGT00760000119163_1_Domain_24 (4410, 4530)

DELQKFLQDHQEFENWLERSERELEDMHKGG
SC-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDT-ENSFEEGREPL---GTG
ALVKGKLKDATERYTALHSKCTRLGSHLN

ENSGT00760000119163_1_Linker_24_25 (4530, 4533)

MLL

PF00435 // ENSGT00760000119163_1_Domain_25 (4533, 4647)

GQYQQFQSCTDCLQSWIQACEANVEKLL
SDTIASDPGVLQQQLATT-K--QLQEELAEHQVAVEKLQKVAHDLMEIEGEPAPDRKHVQ
E-TTDSILSRFQSLSSSLAERSALLQ

ENSGT00760000119163_1_Linker_25_26 (4647, 4650)

KAI

PF00435 // ENSGT00760000119163_1_Domain_26 (4650, 4757)

ARSQSVQESLESLLQSIREVEQNLEEEQVAS
LSLGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FKQLCLQQQEKESSLK

ENSGT00760000119163_1_Linker_26_27 (4757, 4866)

KLLPQAEVFEHLSDKLQQFMENKSRMLASGNQPDQDIAHFFQQI
QELNSEMEDQQGNLETLEHLVTGLSSCGFALDLSQHQDRVQNLRKDFTELQKTVKEREED
ASSCQ

PF00435 // ENSGT00760000119163_1_Domain_27 (4866, 5023)

EQ-------LDEFRKLVRTFQKWLKETEGNIPPTETFLSAKELEKQIEHL-----
-KG-----LLDDWASKGGLVEEINCKGTSLENLIMEITAPDSQAKTGKRGGGRKEGRSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLRERQESLQ

ENSGT00760000119163_1_Linker_27_28 (5023, 5026)

AVL

PF00435 // ENSGT00760000119163_1_Domain_28 (5026, 5135)

SRMQEVQKEAGSVLQ
WLESKEEVLKAMDASSSPTKPETVRAQADSNKAFLAELEQNSPKIQKVKEALAGLLMTYP
NSQEAENWKEMQEELNSRWERATEATMARQRQLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5138)

ESA

PF00435 // ENSGT00760000119163_1_Domain_29 (5138, 5246)

SHLASFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLTAQKQQVQFMLKEFEARRQQHKQLNEAAQGILTGPGNVSPSTSQVQ
KELQSINQKWIELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVKAVGQRLSGQSAIST
QPEAVKQQLEETSEIRSDVEQLDQEIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAAL

PF00435 // ENSGT00760000119163_1_Domain_31 (5365, 5472)

ASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVAPGEEKKTLQNQLVELKSHWEELS
KKTADRQSRLK

ENSGT00760000119163_1_Linker_31_32 (5472, 5475)

DCL

PF00435 // ENSGT00760000119163_1_Domain_32 (5475, 5579)

QKAQKYQWHVQDLVPWIEDCKAKMSDLQVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNMDSITEELQAKTGSLEEM
TQRLKEFQESFKNIEKRVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQTLEPQVDY
LRNFTRGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCMTMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLHKIQALRLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERSRARQEQLELTL

PF00435 // ENSGT00760000119163_1_Domain_34 (5800, 5908)

GRVEDFYRKLKALNDMTTAAE
EGEALQWVVGTEVDLINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5911)

EAL

PF00435 // ENSGT00760000119163_1_Domain_35 (5911, 6019)

LHCGKFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLEGLE
SRWTGLLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEEIESHATDVHQAVKIGQSLSSLTCSAEQGVLSEKLDSLQARYSEIQDRGC
RKAALLEQAL

PF00435 // ENSGT00760000119163_1_Domain_37 (6131, 6237)

CNARLFGEDEVEVLNWLAEVEDKLSSVFVKDYRQDVLQKQHADHLALNEE
IINRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE

ENSGT00760000119163_1_Linker_37_38 (6237, 6240)

QAR

PF00435 // ENSGT00760000119163_1_Domain_38 (6240, 6346)

Q
LATKFQSTYEELTGWLREVEEELAASGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTVGQRVDEID

ENSGT00760000119163_1_Linker_38_39 (6346, 6349)

AAI

PF00435 // ENSGT00760000119163_1_Domain_39 (6349, 6456)

QRSQQYEQAADA
ELAWVAETKRKLMALGPVRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRGEIFGT
CGDEQKAVLQEKTESLIQQYEAISLLNSERYTRLE

ENSGT00760000119163_1_Linker_39_40 (6456, 6459)

RAQ

PF00435 // ENSGT00760000119163_1_Domain_40 (6459, 6565)

VLVNQFWETHEELSPWIEETRA
LITQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENLYAQIKEEVRQRALALD

ENSGT00760000119163_1_Linker_40_41 (6565, 6568)

EAV

PF00435 // ENSGT00760000119163_1_Domain_41 (6568, 6688)

SQSA---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRCGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFL

ENSGT00760000119163_1_Linker_41_42 (6688, 6691)

DVL

PF00435 // ENSGT00760000119163_1_Domain_42 (6691, 6797)

ELAEKFWYDMAALLTTIRDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDELNNA
WESLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6800)

DAM

PF00435 // ENSGT00760000119163_1_Domain_44 (6800, 6911)

QAAVQYQD----TLQAMFDWLDNAVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLMELKHLWENLGE
KIAHRQHKLE

ENSGT00760000119163_1_Linker_44_45 (6911, 6914)

GAL

PF00435 // ENSGT00760000119163_1_Domain_45 (6914, 7021)

LALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQ

ENSGT00760000119163_1_Linker_45_46 (7021, 7025)

LTLQ

PF00435 // ENSGT00760000119163_1_Domain_46 (7025, 7132)

-QAQGFHSEIEDFLLELTRMETQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7135)

EAL

PF00435 // ENSGT00760000119163_1_Domain_47 (7135, 7241)

NLATEF
QNSLQEFINWLTLAEQNLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD

ENSGT00760000119163_1_Linker_47_48 (7241, 7244)

DAR

PF00435 // ENSGT00760000119163_1_Domain_48 (7244, 7353)

KRAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHKKQEFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7354)

E

PF00435 // ENSGT00760000119163_1_Domain_49 (7354, 7461)

ALLFSGQFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7464)

QAL

PF00435 // ENSGT00760000119163_1_Domain_50 (7464, 7579)

KQAEE-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRADVSTAVAMGEAILAACHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPAHTPFIEKPRGGSR---KSLSQPT
PPPMPILSQSEAKNPRINQL-------------------------------------LKE
FANFDFDVWRKKYMRWMNHKKS

PF00036 // ENSGT00760000119163_1_Domain_53 (7763, 7791)

RVMDFFRRIDKDQDGKITRQEFIDGILA

ENSGT00760000119163_1_Linker_53_54 (7791, 7799)

SKFPTTKL

PF00036 // ENSGT00760000119163_1_Domain_54 (7799, 7827)

EM
TAVADIFDRDGDGYIDYYEFVAALHP

ENSGT00760000119163_1_Linker_54_55 (7827, 7839)

NKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7922)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTK--------------------------
----------KVIPSTGSKLKRPTPTFHSSRTSLAGDTSNSSSPVSTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSQAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
LGPKR

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MPLLDS-SY---------L--PPTIFILTHILGIAGVL----
YWKRYTRG----------RADERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 426)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLKSQGLNTGNICGAQEWRRTHGELTQQ
DDATKK---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF

ENSGT00760000119163_1_Linker_0_2 (426, 443)

QQISDIYISGESGDMSA

PF00307 // ENSGT00760000119163_1_Domain_2 (443, 543)

KEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVKIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGINATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKSFPQNPVELKVNFV
NEFYCFSEDRRIYGKCRRNGRIESRQSLHVWIEFGRIKLPQGYHPNNVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
VMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELITLRLECTNLYRKGHFT
TLELVPPST-------LTTTHLKTVPLTKGTHS--------------SSTSWFRKPMTRA
ELVSISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQLIHTSVEEL
GSSVKEARLYEGKMSQNFHT-SYVETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNPNISAKRNYFSELTMELEEKQ-DVFQSLQDTADL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARDLEAFLRNL
QDSIKRKYSCDHSTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKAIVQLKPRSP
DHVLKSTISVKAICDYRQIEITVCKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIETASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVKSWNMEKLRSLAP
GEYHQLMKNLQA----HYEDFLQDSHDSVLFSVADRLCLEEEVDSCKTHFQHLLKSIENE
DKEETMAKMHISELKNIQLRLEECEQRLVKRIQSLVSSRTDEDARQDNALRIAEQEHTQE
DLQQLRSDLNDVSMKCNSFLHQSPSGSSVPTLRSELNLLVEKMDRVYGLSTVYLNKLKII
DVIIRSIQDAELLVKGYEIKLSQEEAVPANLSALESYQSTLRHWLSDIKDKNSVFLVLDE
EIAKAKVVAEQLSRLTQERNLDLERFQEKGCQLQERWHRVI-AQIETRQSELESIQEILG
DYRACHGKLIKWIEETTTQQEKMKPGQAEDSRVLSEQLRQQTNLFAEIERNQTKLDQCQN
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRVLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQEKFTSS-QTKES
TDIEKAILEQQVLAEELTTKKGQVSETIKTSQIFLAKHGHKLSEKEKEQISEQLNALNKI
YHDLCDDSANQLQQLQNQLAQHTEQKGCRA--VAGVIDLGT--VEIFPIFRAMQKGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1908)

LVLLESQVIMSGLIAPETSEKLSLEESLARNLIDHQMYQQLQEL

ENSGT00760000119163_1_Linker_7_8 (1908, 1945)

QDAVSLINR-LTE
GKG---PLSVLEAIEKRIISKKIG

PF00681 // ENSGT00760000119163_1_Domain_8 (1945, 1987)

LKILEAHLATGGFCLSPSENCINLEEAFGQGFITPW
LHSELDSHLRSSKNLIDPNTAEKIGLLDLMQRCIVHQESGLKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2100)

RLLEAQLFAGGIVDPRTGHRLTVEGAVRHNLIDQDMACAI

ENSGT00760000119163_1_Linker_10_11 (2100, 2102)

L
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2139)

RQLQMGGIIDTATQRRLTIDEAVSNDLLAAKIALVIL

ENSGT00760000119163_1_Linker_11_12 (2139, 2146)

ESLWSFM

PF00681 // ENSGT00760000119163_1_Domain_12 (2146, 2177)

GLLWPESGEILPITD
ALEQGIVSTELAHKIL

ENSGT00760000119163_1_Linker_12_13 (2177, 2641)

SGRQHIKALFLPATTEVWSWKKAIENGILDKDLANNLKSICIPD
VMPHVQLADSSEQSKLSINLGTAAL---PCSRDQT-----EN-IASDRER-LLFQLVTHS
YINVWNGQRLLLLDKELVEILT--PKCEYQ-TRPA---EVSGIGHLKLEIPEQLQE--ST
NVRITET-FHNGLSVRPCEFQFSSQSREFLNQKIFTEAKG-------KKSS--------V
ENPGKDLFIGEQNIRNPNGDTLK-VINKVKSELQRQILGTKNKDQGEMSTREN-----VG
SGLFFTVP-SEEAE-VHLVLNKDLFSVETPKEEWQAL--RKTSFTYQKEQA--SALEIEH
IPGEAGRPL---IKPQSKESQFQIG-KTLDLESELKSENYMSIYFLDKKKVLNK--M---
----PLGD--HKQSQEEENIV-GSSTIMLEKINEEANGDKTSLPCS----QPSKLLEETT

PF00681 // ENSGT00760000119163_1_Domain_13 (2641, 2683)

LNILSAQLLDGGIVHEQTGKKLLLNEAVAQGVVPSHTAVKLM

ENSGT00760000119163_1_Linker_13_14 (2683, 2719)

EKLRMFRGFLDSQTCESL
TTKEVIDEGLMDEKLL-H

PF00681 // ENSGT00760000119163_1_Domain_14 (2719, 2760)

NVLLADKAISGIIDPRTHTLCSVKDAVAVGLLDKQTATRILEGQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQIELLSLEKASKGRDAEKTCREKLIGLQMEITGIMDPDTKAPLTVVQSINQGLLKREEAIQLLTKQVVDGGIIHHVSGIRLSVDNAFKHGLINEDLCKQLKKVENLKLHQFSYPNTKETVSLPEAIKLDLLTPELKKEIHEIQALTGNFVDLISGQRLTLAEAKKEGLLT----NKAVLSSGMMHGVIDPENHRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSGKVLTLSQATQVGKVDFAPTLRVLEAQANTGGIIDTITGKKLTLATALEQKMVDENMIRIIAS-----HQVLNGGIVDVFNGQRVTLKEAIEKKYISPELATMIQIDTFEFTDHR-GQIEKEDE-TDLCELKNEVLGKEMFFTCNQTVEMSC--GKGETKRLF-QIGSQSAEENVNLRVS-----------AKKSRDISLKELECSDQEKRRVSPD---ANESVNIIIPCNL-SKSL--DHVSVSYPH--AEVCNFKIEEVVWNKIGKNTN----EEQEKRVMQAEILSLMKQS-TSEPNSKE-RENLGEMIS-EMQE-SNCEAS------GKLLSEQAMQKPMNT--KVKSKREKREMFIEERVKICKPAILLEEKLNQETAVRDEHDSNIKSQPMDITICEKGKEA-DRDLEFSVISKAEDSYS-QMIPEGISIRNQHILTLFNSKQV----NEGEVK-----------NVNLYSTLKPEGNLFQEIIGGAQG-EPFFSVIPRP-EGLHYQESVGKAQDSDASHISK-AGKSFQGTTRQEANYYQD-FSISFKTRETK--DLIFS---S-ND-YKEIS-YQMVPFDSTRA-------------------LRL-EE-MTVSRVDPKEVSCLEFSDRKVLHHQDSKSDHGLCGILKSK-V--TTQEIIEEKILEIADSI-ITDPKV--GSLEGIVTQEDPRVLVSLLPEKLF--QDVS----RKESTGQQDAI-ISPTVPEFSEEKT-GPLKACPTMKMDE--------------KTAQEKLRESPGS---------EL------TSFMTAPGGKGNEGV--NSEPF---RATKNIYN--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQSQ----ELTLTELQNLFCQAKVLDRELKDLSTLVNQELDYVDQIIIGQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHLQNVV-EAKQTRVLNQHIQLKDRIQDLMSWIANTNFILNSKEFNSE--T-DAANLNHYLQQYEDMKQPMAKRKSQLDALAFDIQFFVSEHAQDLSPQQNRQMLRLLSELQRSFQDLVELTTAQTDDLQSRLQQMEQADWVK-TLQKQQNTCHQKLEDLCSWVEQAERTLVSQQ-GRVTQQDLSALQKSQSNLKDLQDDIQNHATSFASVVKDIEGFLEENQTKLTPHELAALQEKLQQAKKQYEALQERTRVAQKELEETVTSVLQQETEKSKAAKELAENRSKIDALLNWVTSLG----------S--SGGQLQSSLPRMEQISGVS--LGKEALDTNDGH-MEENQAPEKLDQQCIKIKARHQELLSQQQNFILATQSAQAFLGQHGHNLTPEEQQMLQEKLGELKEQYATSLAQSEAELKHVQTLQDELQKFLQDHKEFENWLERSEKELENMHKGTSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSLEESRELS---ATGNLVKDKLRDATERYTALHSKCAWLGSHLNMLLGQYQQFQSSADSLQAWMQACETNVEKILSDTVASDPAVLQQQLATT-K--QLQEELAEHQVPVEKLQKVAYDLMEIEGEPAPDHKHVQK-TTDAILSQFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVGKNLEGEQVASLSSGVIQEALATNMKLKQDIARQKSSLEATHEMVTRFMETADSST-AVMLQGKLTEVSQCFKQLCLQQQEKESSLKKLLSQAEVFEHLSNKLQQFMENKSRMLASGNQPDQDIAQFFQQIQELNLEMDDQQENLGTLEDLVAELSSSGFALDLSQHQGRVQNLKKDFTELQRTVKEREEDASSCQEL-------LVEFRKLVRTFQKWLKETEGSIPPTETFMNTKELEKQNEHL------KG-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGLLQERKDNLQVVLNRMQEVQEEASSVLQWLESKEEILKAMNACSSPTKTETVRAQAEANKAFLAELEQNSPKIQKVKEALAGLLLTYPNLQEAENWKKMQEELNSRWEKATEVTVARQRQLEESASHLAHFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARKQQHDQLNKAAQGILMGPGDVSPSTSHVQKELQSINQKWVELTDKLNSRSSQIEQAVVRSTQYQEMLQDLSEKVKAIGQRLSCQSAISTQPEAVKQQLEETSEIRSDLEQLDHEIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPFQGLEDL------AADQMNRLQAALASTQQFQQMFDELRTWLDGKQSQQAKTSPISAKLGQLQFQLQENEEFQKSLNQHSGSYEMIVAEGESLLLSVPPGEERKTLQNQLFDLKSQWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIKDCKAKMSDLQVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNMDAITEELQAKTGSLEEMTQRIKEFQESFKNIEKKVEAAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVADAPDGSDASQLLHQAEVTQQEFLEVKHRVNSGCMTMENKLEGIGLFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEAECRQMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKVLNDMTTAAEEGEALQWVVGTEVDIINQQLADFKTFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQGLENDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLGSRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSATEKKLANSEPLGTQTAKIQQQIIRHKALQEEIESHATDVHQAVKTGQSLSSLTCSAEQGVLSEKLDSLQARYSEIQDWCCRKAALLEQALANARLFGEDEVEVLNWLAEVEDKLSSVFVKDYKREVLQKQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTHEELTGWLREVEEELAASGRQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVTDANEQYRLVSDAIGQRVDEIDAAIQRSQQYEQAADTELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKVSNTNVPPLPQSKNTLLKGHMPISKMTGQENSFVDQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETQTLIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVEEKYRKAENVYAQIKEEVRQRALALDEAISQSV---Q-------FHDKIEPMLETLENLSSRLHMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSRGADKDLAAKEIQDKLDQMVFFWEDIKAQAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIIHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAYRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQHLQSALQ-QAQGFHSEIEDFLLELTKMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEDTYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWQVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIATSPSLILNTVLAQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAECHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPDDTQKLDDLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEE-------FRDTVHMLLEWLSEAEQSLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAICHPDCITTIKHWITIIRARFEEVSFTLSARGHSQRLEATL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2798)

RILE
GQVVTGGIVDLKRGKKVSVTLASNLGLVDSADQIELLSLEKASKGRDAEKTCREKLIGLQ
MEITGIMDPDTKAPLTVVQSINQGLLKREEAI

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2895)

QLLTKQVVDGGIIHHVSGIRLSVDNAFK
HGLINEDLCKQLKK

ENSGT00760000119163_1_Linker_17_19 (2895, 2933)

VENLKLHQFSYPNTKETVSLPEAIKLDLLTPELKKEIH

PF00681 // ENSGT00760000119163_1_Domain_19 (2933, 2967)

EIQALTGN
FVDLISGQRLTLAEAKKEGLLT----

ENSGT00760000119163_1_Linker_19_20 (2967, 3042)

NKAVLSSGMMHGVIDPENHRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSGKVLTLSQATQVGKVDFAPT

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3090)

LRVLEAQANTGGIIDTITG
KKLTLATALEQKMVDENMIRIIAS-----HQVLNGGIVDVFNGQRVTLKEAIEKKYISPE
LATMIQIDTFEFTDHR-GQIEKEDE-TDLCELKNEVLGKEMFFTCNQTVEMSC--GKGET
KRLF-QIGSQSAEENVNLRVS-----------AKKSRDISLKELECSDQEKRRVSPD---
ANESVNIIIPCNL-SKSL--DHVSVSYPH--AEVCNFKIEEVVWNKIGKNTN----EEQE
KRVMQAEILSLMKQS-TSEPNSKE-RENLGEMIS-EMQE-SNCEAS------GKLLSEQA
MQKPMNT--KVKSKREKREMFIEERVKICKPAILLEEKLNQETAVRDEHDSNIKSQPMDI
TICEKGKEA-DRDLEFSVISKAEDSYS-QMIPEGISIRNQHILTLFNSKQV----NEGEV
K-----------NVNLYSTLKPEGNLFQEIIGGAQG-EPFFSVIPRP-EGLHYQESVGKA
QDSDASHISK-AGKSFQGTTRQEANYYQD-FSISFKTRETK--DLIFS---S-ND-YKEI
S-YQMVPFDSTRA-------------------LRL-EE-MTVSRVDPKEVSCLEFSDRKV
LHHQDSKSDHGLCGILKSK-V--TTQEIIEEKILEIADSI-ITDPKV--GSLEGIVTQED
PRVLVSLLPEKLF--QDVS----RKESTGQQDAI-ISPTVPEFSEEKT-GPLKACPTMKM
DE--------------KTAQEKLRESPGS---------EL------TSFMTAPGGKGNEG
V--NSEPF---RATKNIYN--------RRLCLEHDEKLVSYLSLLRDIEMRTKQIQSQ--
--ELTLTELQNLFCQAKVLDRELKDLSTLVNQELDYVDQIIIGQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHLQNVV-EAKQTRVLNQHIQLKDRIQDLMSWIANTNFILNS
KEFNSE--T-DAANLNHYLQQYEDMKQPMAKRKSQLDALAFDIQFFVSEHAQDLSPQQNR
QMLRLLSELQRSFQDLVELTTAQTDDLQSRLQQMEQADWVK-TLQKQQNTCHQKLEDLCS
WVEQAERTLVSQQ-GRVTQQDLSALQKSQSNLKDLQDDIQNHATSFASVVKDIEGFLEEN
QTKLTPHELAALQEKLQQAKKQYEALQERTRVAQKELEETVTSVLQQETEKSKAAKELAE
NRSKIDALLNWVTSLG----------S--SGGQLQSSLPRMEQISGVS--LGKEALDTND
GH-MEENQAPEKLDQQCIKIKARHQELLSQQQNFILATQSAQAFLGQHGHNLTPEEQQML
QEKLGELKEQYATSLAQSEAELKHVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4486)

ELQKFLQDHKEFENWLERSEKELENMHKGT
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-EN

ENSGT00760000119163_1_Linker_24_25 (4486, 4534)

SLEESRELS---ATG
NLVKDKLRDATERYTALHSKCAWLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYQQFQSSADSLQAWMQACETNVEKIL
SDTVASDPAVLQQQLATT-K--QLQEELAEHQVPVEKLQKVAYDLMEIEGEPAPDHKHVQ
K-TTDAILSQFQSLSCSLAERSALLQKAIAQSQSVQESLESLLQSIREVGKNLEGEQVAS
LSSGVIQEALATNMKLKQDIARQKSSLEATHEMVTRFMETADSST-AVMLQGKLTEVSQC
FKQLCLQQQEKESSLKKLLSQAEVFEHLSNKLQQFMENKSRMLASGNQPDQDIAQFFQQI
QELNLEMDDQQENLGTLEDLVAELSSSGFALDLSQHQGRVQNLKKDFTELQRTVKEREED
ASSCQEL-------LVEFRKLVRTFQKWLKETEGSIPPTETFMNTKELEKQNEHL-----
-KG-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQAKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGLLQERKDNLQVVLN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMQEVQEEASSVLQ
WLESKEEILKAMNACSSPTKTETVRAQAEANKAFLAELEQNSPKIQKVKEALAGLLLTYP
NLQEAENWKKMQEELNSRWEKATEVTVARQRQLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5140)

ESASH

PF00435 // ENSGT00760000119163_1_Domain_29 (5140, 5246)

LAHFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARKQQHDQLNKAAQGILMGPGDVSPSTSHVQ
KELQSINQKWVELTDKLNSRSSQIEQAVVRSTQYQEMLQDLSEKVKAIGQRLSCQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEIKEAQTLCDELSVLIGEQYLKDELKKRLETVALPF
QGLEDL------AADQMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDGKQSQQAKTSPISAKLGQ
LQFQLQENEEFQKSLNQHSGSYEMIVAEGESLLLSVPPGEERKTLQNQLFDLKSQWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIKDCKAKMSDLQVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSETDEDDIRDEKAGINQNMDAITEELQAKTGSLEEM
TQRIKEFQESFKNIEKKVEAAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY
LRNFTQGLVADAPDGSDASQLLHQAEVTQQEFLEVKHRVNSGCMTMENKLEGIGLFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIQVLKLDIEASEAECRQMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKVLNDMTTAAE
EGEALQWVVGTEVDIINQQLADFKTFQKEQVDPLQMKLQQVNGLGQGLIQSAGKNCDVQG
LENDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLG
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6128)

AKQFHETAEPISDFLSATEKKLANSEPLGTQTAKIQQ
QIIRHKALQEEIESHATDVHQAVKTGQSLSSLTCSAEQGVLSEKLDSLQARYSEIQDWCC
RKAALLEQALANARLFGEDEVEVLNWLAEVEDKLSSVFVKDYKREVLQKQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ
LATKFQSTHEELTGWLREVEEELAASGRQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVTDANEQYRLVSDAIGQRVDEIDAAIQRSQQYEQAADT
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKVSNTNVPPLPQSKNTLLKGHMPISKM
TGQENSFVDQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETQT
LIAQLPPPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVEE
KYRKAENVYAQIKEEVRQRALALDEAISQSV---Q-------FHDKIEPMLETLENLSSR
LHMPPLIPAEVDKIRECISDNKSATMELEKLQPSFEALKRRGEELIGRSRGADKDLAAKE
IQDKLDQMVFFWEDIKAQAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIIHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6802)

DAMQA

PF00435 // ENSGT00760000119163_1_Domain_44 (6802, 6910)

AVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAYRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQHL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
SALQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTKMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKED
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWQVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIATSPSLILNTVLAQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAECHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
DDTQKLDDLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7572)

QAEE-------FRDTVHMLLEWLSEAEQSLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNAAVAMGEVILAICHPDCITTIKHWITIIRAR
FEEVSFTLSARGHSQRLEATL---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-----

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQKKRKSQDS----
VLDPAERAVVR-------VADERDR

PF00307 // ENSGT00760000119163_1_Domain_0 (266, 427)

VQKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPSWRHTNNEEQAE
EDDDDV---PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 441)

QISDIYISGESGDM

PF00307 // ENSGT00760000119163_1_Domain_2 (441, 544)

SAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALY-
NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDV
IMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFT
SLELVPPST-------LTTTHLKAEPLTKATHS--------------SSTSWFRKPMTRA
ELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGSDLPSVELQLETQQHIHTSVEEL
GSSVKEARLYEGKISQNFHT-SYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATA
ELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQ-DVFRSLQDTAEL-----
LSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNL
QDSIKRKYSCDHNTSLSRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLKPRSP
DHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAP
GECHQVMKNLQA----HYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENE
DKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDARQDNALRIAEQEHTQE
DLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTV
DVIARSIQDAELLVKGYEIKLSQEEAVLADLSALEAHRSTLRHWLSDVKDKNSVFSVLDE
EIAKAKAVAEQMSRLTPERNLDLEHYQEKGSQLQERWHRVI-AQLEIRQSELESIQEVLG
DYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQK
FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS-ETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKA
YHDLCDGSANQLQQLQSQLAHQTEQKECRA--VAGVIDLGT--VEIFPIFKAMQKGLLDQ
DTGL

PF00681 // ENSGT00760000119163_1_Domain_7 (1865, 1904)

VLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISR-LTE
SRG---PLSVVEAIEKRIISERVGLKILEAHLATGGFNLSPSENCINLEEAFHQGLISAW
LHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGR
KVSIFRAVQEGLIDRQVTV

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2099)

RLLEAQLFAGGIVDPRTGHRLTVEEAIRHNLIDQDMACA

ENSGT00760000119163_1_Linker_10_11 (2099, 2102)

IL
I

PF00681 // ENSGT00760000119163_1_Domain_11 (2102, 2138)

RQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD
ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD
VMPHMQLADS---AEQNINPGAAVL---PCSKSQP-----KA-IASQSEN-LLFQLMTHS
YINVQNGQRLLLLDKELMETLT--SRDEYQ-TSPP---KVVEIGHQRQKTPEGLQE--SA
NVKISGT-FSDGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSS--------V
ENPEQDLFVEQ-KKRNPNIDALK-VINKVKLEVQRQLIGTKREDQTAVSIREN-----AS
RGHLLTIP-PAEAEGVPLVVDKDVFSVETPKKEHQ--PLRNTSFTCQNEQA--HTLETEY
IHDETGGSH---IKPQNKKSQVQVK-KTLGIKLELKSETDGNVHPLDKKEMLKKTFL---
----AKDD--HKESQEAQNIA-GGSMMMLEKTDEEDSGREIFLSCS----HPLELLEEAT
LNV

PF00681 // ENSGT00760000119163_1_Domain_13 (2644, 2681)

LSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVK

ENSGT00760000119163_1_Linker_13_14 (2681, 2721)

LMEKLNMFQGFFDSQTCESL
TTEEVINEGLMDEKLL-HNV

PF00681 // ENSGT00760000119163_1_Domain_14 (2721, 2759)

LMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSRAPLTVGQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENVSLPKAIKLDLITPDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANSGGIIDTATGKRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHR-AQIEKQEG-IEVCALQNEFLRKDMLIACNQTAEMSC--NKVEESERLFQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFGCKDQRKPRMSSD---AKEFISIINPHNLKGKSL--GQVSLTHPY--SEVCDFKLKEVARNNMGNDTN----EEQEKAVTKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQVLQQPMNA--GVKSKREKREVIVEESIRTCKSAFLSDQ----ETAIRDEHDSHIKSQPREMTSSEKGKEA-DTEMGFSITFKIEESSS-QVVPQGISVKHLDALTLFSSKQA----NEGKVN-----------NLSLCLTLKPEENLSREIACGAQS-EPFPCMTPRP-EGLHYQESDGKAQVTGPSQISK-TDKSFQGTTRQETNYHQD-SWVTSKTKETK--HQISS---S-NE-CKEKS-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLECSDRKDLHHQGSKSDDKLCGTLKSE-I--ATQELTGEEFLEMANPN-VAGLEA--RSIEDIVTQRGSGVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVLETSEEKT-VSLTVC-SAVKTE--------------KTPQEKLRESPGS---------EQ------TPFMTAPEGKGNGGV--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPL----ELNLAELHDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSE--I-DVDSLNRCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQVEQEALVK-TLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEQTRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSGAS--LEKGALDTTDGY-MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHREFESWLERSEKELENMHKGGSS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSFKEGKEPS---EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQTCEANVEKLLSDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQE-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL------KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSVGSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL------AADRMNRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNVDAVTEELQAKTGSLEEMTQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEMLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETQALIAQLPAPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQST---Q-------FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQLQSTL-QQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDTQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEV-------FRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKIIEPTHAPFIEKSRSGGR---KSLSQPTAPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP--------------------------------------------KKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRTPGP

PF00681 // ENSGT00760000119163_1_Domain_15 (2757, 2789)

RILE
RQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQ
METTGLIDPDSRAPLTVGQSIDRGLLEREEAV

PF00681 // ENSGT00760000119163_1_Domain_17 (2853, 2892)

RLLTKQVVDGGIIHHISGMRLSVDNAFR
HGLIGEDLAEKLKRVENLNIHQIFNPETKENVSLPKAIKLDLITPDLKREIQEVQAFTGN
FVDLISGQRLTLAEAKKEGLLT----NEAVLSPGMMHGIVDPENCRIVPYSELVKKCKID
IESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLK

PF00681 // ENSGT00760000119163_1_Domain_20 (3044, 3080)

VLEAQANSGGIIDTATG
KRLTLASALEEKLVDENMVRIIAS-----HQVLNGGIVDIFSDQRVTLVEAIEKRLISPE
LANMIQIDSSEFSDHR-AQIEKQEG-IEVCALQNEFLRKDMLIACNQTAEMSC--NKVEE
SERLFQVENQSAQEKVKVRVSDGE-------QAKKSREISLKEFGCKDQRKPRMSSD---
AKEFISIINPHNLKGKSL--GQVSLTHPY--SEVCDFKLKEVARNNMGNDTN----EEQE
KAVTKIEIISHMKQS-TSCLDSEEIRENQGEVIL-EVQE-TYCETS------GKLPSEQV
LQQPMNA--GVKSKREKREVIVEESIRTCKSAFLSDQ----ETAIRDEHDSHIKSQPREM
TSSEKGKEA-DTEMGFSITFKIEESSS-QVVPQGISVKHLDALTLFSSKQA----NEGKV
N-----------NLSLCLTLKPEENLSREIACGAQS-EPFPCMTPRP-EGLHYQESDGKA
QVTGPSQISK-TDKSFQGTTRQETNYHQD-SWVTSKTKETK--HQISS---S-NE-CKEK
S-YQEVSFDPARG-------------------LKL-EE-ITVSRPDSKEVSYLECSDRKD
LHHQGSKSDDKLCGTLKSE-I--ATQELTGEEFLEMANPN-VAGLEA--RSIEDIVTQRG
SGVLGSFLPEKLF--KGVS----QKENTGQQNAI-ISPTVLETSEEKT-VSLTVC-SAVK
TE--------------KTPQEKLRESPGS---------EQ------TPFMTAPEGKGNGG
V--NPEPF---RATQNVFT--------RQLCLEHDEKLVSYLSLLRNIEMRTKQIQPL--
--ELNLAELHDLLCQAKVLDRELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDA
KNLQKSLSSVSDTWNSRLLHFQNAV-EIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNS
KGSNSE--I-DVDSLNRCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNR
QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQVEQEALVK-TLQKQQNTCHQQLEDLCS
WVGQAERALAGHQ-GRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEQTRVAQKELEEAVTSALQQETEKSKAAKELAE
NKKKIDALLDWVTSVG----------S--SGGQLLTNLPGMEQLSGAS--LEKGALDTTD
GY-MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML
QQKLGELKEQYSTSLAQSEAELKQVQTLQD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4488)

ELQKFLQDHREFESWLERSEKELENMHKGG
SS-PEALPSLLKRQGSFSEDVISHKG-DLRFVTISGQKVLDM-ENSF

ENSGT00760000119163_1_Linker_24_25 (4488, 4534)

KEGKEPS---EIG
NLVKDKLKDATERYTALHSKCTRLGSHLNMLLG

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

QYHQFQNSADSLQAWMQTCEANVEKLL
SDTVASDPGVLQEQLATT-K--QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ
E-TTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSS
LSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT-AAVLQGKLAEVSQR
FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI
QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD
ASSCQEQ-------LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHL-----
-KS-----LLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL---PSVGSSV
GSVNGYHTCK-DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN

PF00435 // ENSGT00760000119163_1_Domain_28 (5027, 5135)

RMEEVHKEANSVLQ
WLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP
NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM
MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ
KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST
QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL
QGLEDL------AADRMNRLQAALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

TQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER
LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS
KKTADRQSRL

ENSGT00760000119163_1_Linker_31_32 (5471, 5476)

KDCMQ

PF00435 // ENSGT00760000119163_1_Domain_32 (5476, 5579)

KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM
LSEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNVDAVTEELQAKTGSLEEM
TQRLKEFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEMLQALEPQVDY
LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV
REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE
EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYRKLKGLNDATTAAE
EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQG
LEHDMEEINARWNTLNKKVAQRIAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELIANQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE
SRWTELLSKAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6127)

AKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ
QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC
RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE
IVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYTDITVTSSKALRTLEQARQ
LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT
CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6565)

NQFWETYEELSPWIEETQA
LIAQLPAPAIDHEQLRQQQE-EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE
KYQKAENMYAQIKEEVRQRALALDEAVSQST---Q-------FHDKIEPMLETLENLSSR
LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE
IQDKLDQMVFFWEDIKARAEEREIKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6803)

DAMQAA

PF00435 // ENSGT00760000119163_1_Domain_44 (6803, 6910)

VQYQD----TLQAMFDWLDNTVIKLCTMPPVGTDLNTV
KDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EGALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRSRLETMNQCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STL-Q

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE
TYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7136)

EALN

PF00435 // ENSGT00760000119163_1_Domain_47 (7136, 7240)

LATEF
QNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLIDWL
EDAESHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKTLLP
EDTQKLDNFLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQALVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE
LSTRWDTVCKLSVSKQSRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7467)

QALKQA

PF00435 // ENSGT00760000119163_1_Domain_50 (7467, 7578)

EV-------FRDTVHMLLEWLSEAEQTLRFRGAL
PDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRAR
FEEV--LTWAKQHQQRLETALSELVANAELLEELLAWIQWAE-TTLIQRDQEPIPQNIDR
VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKIIEPTHAPFIEKSRSGGR---KSLSQPT
APPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE----------LKE
FANFDFDVWRKKYMRWMNHKK

PF13499 // ENSGT00760000119163_1_Domain_52 (7762, 7823)

SRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVA

ENSGT00760000119163_1_Linker_52_55 (7823, 7841)

ALHPNKD-AYRPTTDADK

PF02187 // ENSGT00760000119163_1_Domain_55 (7841, 7920)

IEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRV
HHPGSKIKRSDSSSSISSQSPIARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCTSMPSSPATPASGTKTSLQFSRCYDKPWLVNSKAGTPIRDS
HSPDLQLPTPEVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADP----
----------------------------------------KKSASRPGSRAGSRAGSRAS
SRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRRGL--NKPSKIPTMSKKTTTASPRT
PGPKR

------------------------------------------------------------
------------------------------------------------------------
----------------MSSSD-------EETLSERSC---RS-------ERSCRSERSYR
S-------ERSG----SLSPCPPG-DT---------L--PWNLPLHEQRKRKSQDS----
VLDPAERAVVR-------VADERDRV

PF00307 // ENSGT00760000119163_1_Domain_0 (267, 427)

QKKTFTKWVNKHLMK-------------------
-VR---KHINDLYEDLRDGHNLISLLEVLSGVKL--------------------------
---------PREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWT
IILHF-

ENSGT00760000119163_1_Linker_0_2 (427, 443)

QISDIYISGELGDMSA

PF00307 // ENSGT00760000119163_1_Domain_2 (443, 543)

KEKLLLWTQKVTAGYIGLKCTNFSSCWSDGKMFNALIH
RYRPDLVDMERVQIQSNRENLEQAFEIAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIY
DAFPKVPEGGEGISAIEVDSRWLEYQSRVESLISWIKQHTILMSDKSFPQNPVELKALY-
NQYIHFKETEIPAKEQEKGQIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEML
EREKLLRPAVERLELLLQIANKIQNGALSCEEKLTLAKNTLQADAAHLESGQQVQHEADV
VAFLQECEGLVRQLQVDLQILRDENYFQLEELVFRIVRLQDELVTLRLECTNLYRKGHFS
TLELVPTST-------LSTTQLKGDSLTKGLHT--------------SSASWFRKPMTRP
ELVAISSSEDEGSLRFVYELLAWVEEMQMRLERAEWGTDLPSVESQLESQRHIHASVEEL
GSSVKEARMYEGKMSPNFRA-SYTETLGKLETQYCKLMETSSFRLRHLQSLHGFVSRATA
ELIWLNEKEEEELAYDWSDNNPNIAAKKNYFSELTAELEEKQ-DIFHSLQDTAEL-----
LSLENHPAKQTVEAYSAAVHTQWQWIKQLCLCVEQHVKENAAYFQFFSDARESEAYLRNL
QDSIRRKYSCDHNTSLTRLEDLLQDSM--DEKEQLIQSKSSVASLVGRSKTIVQLRPRNP
EHALKGTIPIKAVCDYRQIEITICRNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIP
PPNKEAVEMASRVEQLYQKVMALWHQLHMNTKSLISWNYLRKDIALVQSFSVEKLRSLAQ
GECQQALKSLQA----HYEDFLQDSRDSELFSVSDRLRLEEEVESAKEHIRQLLESMENE
DKDETVARTFLSELGNIRLRLEECELRLLSRVQPAGSAQAGADPAQENAVRMAEQERTQE
DLQQLQSELRVVSERCCSFLDKAPAGPSTPQLRSELDLVVNKMEQTHGLSSIYLEKLKTV
DVIIRSTQGAESLVKGYEVKLSQEEAVPADLAAIQTHRAALQQWLGEVKDKGSVFSTLEE
EMGKAKEVGEQLFRLRQERSIELERFQEKGSQLWERWQRVC-AQIETRHTELESIQEVLS
DYRQCHSALIQWIEEITAQQELMKPGQAEDSRVLSEQLSQQTALAAEIEKNQAKLDQCQK
FSQQYSAAVKDYELQLMTYRAFVESQQKSPMKRRRMLSSSDAITQEFMDLRTRYTALVTL
TTQHVKYISDALRRLEEEEKVVEEEKQEHVDKVKELLGWALGLKQSVQGRAAAA-GSREL
GDIEKSISEQQALNEELTAKKEQVSEAIKTSQIFLAKHSHKLSQPEKDQISAQISALKET
YQALCSNSTEQLQQLQSQLAQETEHKGSEA--VAGVIDLGT--VEIFPVFGAMQRGLIDQ
DTG

PF00681 // ENSGT00760000119163_1_Domain_7 (1864, 1906)

LALLEAQVITSDLVVPETSEKLSLEKALARNIIDVRAFQVLQELKDALQQVEEVRCE
GRQ---LLPVVAAMEEGRISENVGLKILEAELITGGFKFQQGR--ISMETAVQEKLLPPQ
LHSRLLSHLEGGKDLIDPNTAEKTSLPELLERCINHQETG

PF00681 // ENSGT00760000119163_1_Domain_9 (2021, 2065)

LRLLPVQQLAGGMLSLSSGR
EISIPRAAQEGLIDRQVATRLLEAQLCAGGIVEPRTGLRLSVAEAVRQGLMEQDLGCTLLIRQLQRGGIVDTATGHRLSLDEALRKGLVAPNTALLALESLQSFMGLLWPETGEIIPVADALEQGVLSTDLIQEILSKRQLLQAVFVPETTEVLSWQKAVEQGILEGEVAKKLRSTALPDVMGSVQLSASPSRSRHSQSSPGRSP---TG---PG-----EPLLSSDEER-LVFHLMTHSYINIHDGHKVLLVDAELNNLTK--TLIQSQ-ENGS---CAQQL---RGFEETEADA--ALESEPC-----NGLALQQLELQFAPSKGESEKMLPPRTALENGEVVMGPETLL-------LEDAEDFLQMEEQKKVSTEQETIR-SETDAEF------------GREQVTFTTT-----DKHQVKLLMP-EPPSDLDSGLIRETEEMIIEREEESKPP--AEDGVEGPEYQK--RAKLESGAVV---------VKKSRDRLKIVAE-RSQGVREPEGEAEGAREVYLLKEEVVEDGGEEVVLPARGEAE--RQSEDVGSVLEVEE--GEQEEATRIEKLGDEGSEKP----APEEQEAEDTLEKLLRQLQSGGISQEQTGRALLLDEALTAGLVSGHAAVKLMDRMSMFSGFFDSQVGEPLTTEDVIEEGLMDEKLL-QKVLESDKAISGVLDPGNNFVYSIKDAAAVGLLDKETAMRILEGQVVTGGIVDLKRGKKVSVTLASNLGLIEPRSQTELVKLEKASKGKGTDEVSRQKLINLQAETCGIVDPETKQPLTVAESVERGLLEKEKAFQLLAKQVADGGIIHHVSGMRLSVDSAMKHGLVSAELCKELRKAESVVLQEFVHPATKEKLSLPQAVSLGLISPEFQREVQEIQAESGSILHPASGQRLALCQAVQQGLVPQQVVERALSSSAMREGIVDPESCMIVPYSELLKKCKIDIESGQRYLEVHPFQAIKDEVTGTRLPCAEAVRLGKLDPLPALRLLQAQADAGGVVEGTVSKRLSLRAAVEQGVLDEAMAKVIAT-----NQLRAGGIVDAPSGKRLTVKEAVGKGLISQKLAAGLQDVRMPE---------EKVG-SEVCKGEKMQLSQEKI-----EG-LSP--EKAEAEVTP-E------HPSVLGTASL-----------PEQTVVA--GAVEKGIPKGSQVRA---AQGKELREKVDGGTEKVE--RLT--------LEKEKLFLGMEVLHREEDGEE----RRRKEFVGAEGVVAGGEGA-VVTSGQ------GERVTR-VVQE-TPAAPR------ESVSVGP----GKGG--MGPGEPPEVGVPAGDELAGERAVKHTERETSHTEGLIDQEKTS-ETELKPTQKQKSKKKK-AKQGSIPGDGAQAEKPP-AEKQLPPSLVSHEI---------------PRKK-----------GEEEHFEPKHESSSEAAAGLARDT-AKHKGGKGKK-IPGKETPREDRVFPVPPEQGET-PEVLKGGVKDGQDSLVKE-RMAQEDTRLET--TLDVS--------STATV-TQELPHDLIIR-----------------------EE-PPEPRETSPVLELGEEKQQEQRAELRADQGAP---------A-PPKSQEETPQPKFEA-LI-SCLILQ--IKFSKKMCLEHDQRLISYLSMLRD--IEMR----IKRVQPAEQNL-AALHDLRQQAEVS-EPGPG------LA--------------GVR------QSFP---------SS------PQLPAPLLASGSFVSGLTLISC---LILQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA----EQNLAALHDLRQQAEALGTELQELSFPVNQELDAVQRIVANPPEEVPEQLLKALEKDAKNLQKSLSSANEILQSQLQNLRGAA-EAEKAKILAQHEALQAKLQELLSWVSVTTGSLDDSDFQQA--T-DASSLSHCLQHYKELKEPLADTKAELDATAFDIQFLISEHAQDLTPQQSRQLLRLLHELQKAFRDLSERVTARVEVLQVCLQQVEQTEQVKLTLQEQQAARAQSLAELSRWLGQAEDTLAEQQ-RAG--GDLPALQQRQSNVKELQRSIHSRAASFAGVLKSTEQFLEENKAKLEPGELAALQQDLQRAKEQYQSLQERTEVAQKELESAVSAAVQQETEKVKAAKELEENSNKIDSLLSWVASLE----------Q--KGGLPEYRPHPVDPGTGTP--AGKSPGDVPDGQAVGADSAAESLDELYERLKAQHQELLSQQQDVILATQSAQALLERQGHSLAGEQRAQLRAQLAELRQQYPAALARSEARLKRAQLLRDELRKFLRDHGEFQAWLEQAEQELEGMCKGDSD-PASLRQLLRRQGSFSEDVISHKG-DLRFVTMSGQKFLD--GDAEDAESQLV---MSRSVVKSKLEDATQRYTRLHSKCSKLGSHLSTLLDHYQQFQEVAESLRTWLQEGEAALGKLLSEAVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQE-TTDAIVSRFQSLSQQLSERSDLLQKSIAQSQSVQESLESLLQSVAEIERSLEKDQPAVLSSASIQDSLATSVKLKQDIARQKSCLEATREMVTRFTAATDSPA-ASALQDKLAQVTEHFGRLCQQQQQREDTLKGLLPKVEQHEQLLEKLQQFTESRTRALASGNQPERDIARFSQHIQELNSEMRQHQEDLATLEHLAEELSSCGFAPSTFQQQEKLQSLKKDFLQLQKVAKDREKDASSCQEQ-------LDEFRNLVGAVRKWLRESESKIPPAETSLGTQELQQRRQQI------QD-----LLEEWKGKGPQVEEIAHRGTLLENLIVEITAPNTPPKAGATL---PSPGGSGGSVNGYHTCK-DLTEIQCDVSEVGRRYQALGAALQERLQQLSALLDSMQQVQEEASSLLQWLESKERSLSQLDASSSPTRTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYPDSPEAANWKKMQEDLNCRWERASQATAARQQKLEESATQLATFQAAEAQLRPWLMEKELMMSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSSSQVQDELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAISTQPDAVKQQLEETSEIRSDLAQLEEEISEAQSLCDDLSVLIGEQYLKDELRKRLETVALPLKGLEDLADLVAAAADRMNRLQTALASSQQFQHMFDELRTWLDDKRCQQAQSQPISAKLERLQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELSRQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADILTDASQTDEDDVRDEKASINQKMDAITEELQTKTGSIEEMSQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQALEPQVDYLKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKINDCCALMENKLEGIGQFNSRVREMFSQLADLDDELDSMGPIGRDSDSLQSQAEDARAFLGKLQRLKGDIASSEGECKRMLEDEGSPDLLGLKRELETLNKQCSKLAERGRSRQEQVETTLARVEDFYGRLKELSLMTTAAEENEALQWVVGTEVETINQQLADFKQFQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQGLEHDMEEINTRWNTLNKKVAQRVAQLQEALLHCGKFQDALEPLLSWLADTEELISNQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIQAEGERIAQAAEPADRDKIVGQLESLGQRWEGLLARAAARQKQLEDILVLAKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQQISRHKAL-------------------------------------------------------------------------------------------------------------NEEIVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSRALRTLEQARQLATKFQSTHEELAGWMSKVEEELAASGAQSPAGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTIKHRVEEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGTCGEEQKAVLQEKTESLVQQYEAVSQLNSERYARLERAQVLVNQFWETYEELNPWIEETQALISQLPPPAIDHEQLKQQQD-DMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQEKYSRAEALYSKIKEEVCQRALALDEAFSQST---Q-------FHDKMEPMLEALGSLSSRLRLPPLIPAEVDKIRECISDNKSSTVELEKLQPSFEALRRRGEELIARSQGPDKDLAAKVIQDKLDQMVFFWEDIKARTEEREMKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEEAMQAAVQYQD----TLQAMFDWLDNAVIKLCNMSPVGTDLSTVKEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGEKIAHRQHKLEAALLALGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRNRLEKLNSCWESVLQKTEEREQQLQSTLQ-QAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYSQLKAKEDVYSQLLAKGRLMLLNRDDSGSGSKTEQSVALLEQKWCLVSTKMEERKAKLEEALALATDFQNSLQDFINWLTLAEQSLNIAPPPSLILAAVLAQIDEHKVFANEVNAHRDRIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRALDDARKRAKQFHEAWKKLVDWLEDAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKALLADDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAFVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKVQLQELSNRWDTVCKLSVSKQTRLEQALKQAEE-------FRTAVHMLLEWLSEAEQSLRFRGALPDDAEALQALIDGHKEFMKKVEEKRADVNAAVGMGEVILGACHPDCITTIKHWITIIRARFEEV--LTWARQHQQRLESALSELVANAELLEELLAWIQWAE-TTLIQRDQEPMPQNIDQVKALISEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGPFIDKSRSNSE---KSLGQAAPPSMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELCP-E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCASMPSSPATPASGAKV-------------------------------------TPSAGSKLKR--PTFHSSRTSLAGDTSNSSSPVSTGAKTTRADPKKAASK----------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_10 (2060, 2100)

RLLEAQLCAGGIVEPRTGLRLSVAEAVRQGLMEQDLGCTLLIRQLQRGGIVDTATGHRLSLDEALRKGLVAPNTALLALESLQSFMGLLWPETGEIIPVADALEQGVLSTDLIQEILSKRQLLQAVFVPETTEVLSWQKAVEQGILEGEVAKKLRSTALPDVMGSVQLSASPSRSRHSQSSPGRSP---TG---PG-----EPLLSSDEER-LVFHLMTHSYINIHDGHKVLLVDAELNNLTK--TLIQSQ-ENGS---CAQQL---RGFEETEADA--ALESEPC-----NGLALQQLELQFAPSKGESEKMLPPRTALENGEVVMGPETLL-------LEDAEDFLQMEEQKKVSTEQETIR-SETDAEF------------GREQVTFTTT-----DKHQVKLLMP-EPPSDLDSGLIRETEEMIIEREEESKPP--AEDGVEGPEYQK--RAKLESGAVV---------VKKSRDRLKIVAE-RSQGVREPEGEAEGAREVYLLKEEVVEDGGEEVVLPARGEAE--RQSEDVGSVLEVEE--GEQEEATRIEKLGDEGSEKP----APEEQEAEDTLEKLLRQLQSGGISQEQTGRALLLDEALTAGLVSGHAAVKLMDRMSMFSGFFDSQVGEPLTTEDVIEEGLMDEKLL-QKVLESDKAISGVLDPGNNFVYSIKDAAAVGLLDKETAMRILEGQVVTGGIVDLKRGKKVSVTLASNLGLIEPRSQTELVKLEKASKGKGTDEVSRQKLINLQAETCGIVDPETKQPLTVAESVERGLLEKEKAFQLLAKQVADGGIIHHVSGMRLSVDSAMKHGLVSAELCKELRKAESVVLQEFVHPATKEKLSLPQAVSLGLISPEFQREVQEIQAESGSILHPASGQRLALCQAVQQGLVPQQVVERALSSSAMREGIVDPESCMIVPYSELLKKCKIDIESGQRYLEVHPFQAIKDEVTGTRLPCAEAVRLGKLDPLPALRLLQAQADAGGVVEGTVSKRLSLRAAVEQGVLDEAMAKVIAT-----NQLRAGGIVDAPSGKRLTVKEAVGKGLISQKLAAGLQDVRMPE---------EKVG-SEVCKGEKMQLSQEKI-----EG-LSP--EKAEAEVTP-E------HPSVLGTASL-----------PEQTVVA--GAVEKGIPKGSQVRA---AQGKELREKVDGGTEKVE--RLT--------LEKEKLFLGMEVLHREEDGEE----RRRKEFVGAEGVVAGGEGA-VVTSGQ------GERVTR-VVQE-TPAAPR------ESVSVGP----GKGG--MGPGEPPEVGVPAGDELAGERAVKHTERETSHTEGLIDQEKTS-ETELKPTQKQKSKKKK-AKQGSIPGDGAQAEKPP-AEKQLPPSLVSHEI---------------PRKK-----------GEEEHFEPKHESSSEAAAGLARDT-AKHKGGKGKK-IPGKETPREDRVFPVPPEQGET-PEVLKGGVKDGQDSLVKE-RMAQEDTRLET--TLDVS--------STATV-TQELPHDLIIR-----------------------EE-PPEPRETSPVLELGEEKQQEQRAELRADQGAP---------A-PPKSQEETPQPKFEA-LI-SCLILQ--IKFSKKMCLEHDQRLISYLSMLRD--IEMR----IKRVQPAEQNL-AALHDLRQQAEVS-EPGPG------LA--------------GVR------QSFP---------SS------PQLPAPLLASGSFVSGLTLISC---LILQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA----EQNLAALHDLRQQAEALGTELQELSFPVNQELDAVQRIVANPPEEVPEQLLKALEKDAKNLQKSLSSANEILQSQLQNLRGAA-EAEKAKILAQHEALQAKLQELLSWVSVTTGSLDDSDFQQA--T-DASSLSHCLQHYKELKEPLADTKAELDATAFDIQFLISEHAQDLTPQQSRQLLRLLHELQKAFRDLSERVTARVEVLQVCLQQVEQTEQVKLTLQEQQAARAQSLAELSRWLGQAEDTLAEQQ-RAG--GDLPALQQRQSNVKELQRSIHSRAASFAGVLKSTEQFLEENKAKLEPGELAALQQDLQRAKEQYQSLQERTEVAQKELESAVSAAVQQETEKVKAAKELEENSNKIDSLLSWVASLE----------Q--KGGLPEYRPHPVDPGTGTP--AGKSPGDVPDGQAVGADSAAESLDELYERLKAQHQELLSQQQDVILATQSAQALLERQGHSLAGEQRAQLRAQLAELRQQYPAALARSEARLKRAQLLRDELRKFLRDHGEFQAWLEQAEQELEGMCKGDSD-PASLRQLLRRQGSFSEDVISHKG-DLRFVTMSGQKFLD--GDAEDAESQLV---MSRSVVKSKLEDATQRYTRLHSKCSKLGSHLSTLLDHYQQFQEVAESLRTWLQEGEAALGKLLSEAVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQE-TTDAIVSRFQSLSQQLSERSDLLQKSIAQSQSVQESLESLLQSVAEIERSLEKDQPAVLSSASIQDSLATSVKLKQDIARQKSCLEATREMVTRFTAATDSPA-ASALQDKLAQVTEHFGRLCQQQQQREDTLKGLLPKVEQHEQLLEKLQQFTESRTRALASGNQPERDIARFSQHIQELNSEMRQHQEDLATLEHLAEELSSCGFAPSTFQQQEKLQSLKKDFLQLQKVAKDREKDASSCQEQ-------LDEFRNLVGAVRKWLRESESKIPPAETSLGTQELQQRRQQI------QD-----LLEEWKGKGPQVEEIAHRGTLLENLIVEITAPNTPPKAGATL---PSPGGSGGSVNGYHTCK-DLTEIQCDVSEVGRRYQALGAALQERLQQLSALLDSMQQVQEEASSLLQWLESKERSLSQLDASSSPTRTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYPDSPEAANWKKMQEDLNCRWERASQATAARQQKLEESATQLATFQAAEAQLRPWLMEKELMMSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSSSQVQDELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAISTQPDAVKQQLEETSEIRSDLAQLEEEISEAQSLCDDLSVLIGEQYLKDELRKRLETVALPLKGLEDLADLVAAAADRMNRLQTALASSQQFQHMFDELRTWLDDKRCQQAQSQPISAKLERLQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELSRQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADILTDASQTDEDDVRDEKASINQKMDAITEELQTKTGSIEEMSQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQALEPQVDYLKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKINDCCALMENKLEGIGQFNSRVREMFSQLADLDDELDSMGPIGRDSDSLQSQAEDARAFLGKLQRLKGDIASSEGECKRMLEDEGSPDLLGLKRELETLNKQCSKLAERGRSRQEQVETTLARVEDFYGRLKELSLMTTAAEENEALQWVVGTEVETINQQLADFKQFQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQGLEHDMEEINTRWNTLNKKVAQRVAQLQEALLHCGKFQDALEPLLSWLADTEELISNQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIQAEGERIAQAAEPADRDKIVGQLESLGQRWEGLLARAAARQKQLEDILVLAKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQQISRHKAL-------------------------------------------------------------------------------------------------------------NEEIVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSRALRTLEQARQLATKFQSTHEELAGWMSKVEEELAASGAQSPAGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTIKHRVEEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGTCGEEQKAVLQEKTESLVQQYEAVSQLNSERYARLERAQVLVNQFWETYEELNPWIEETQALISQLPPPAIDHEQLKQQQD-DMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQEKYSRAEALYSKIKEEVCQRALALDEAFSQST---Q-------FHDKMEPMLEALGSLSSRLRLPPLIPAEVDKIRECISDNKSSTVELEKLQPSFEALRRRGEELIARSQGPDKDLAAKVIQDKLDQMVFFWEDIKARTEEREMKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEEAMQAAVQYQD----TLQAMFDWLDNAVIKLCNMSPVGTDLSTVKEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGEKIAHRQHKLEAALLALGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRNRLEKLNSCWESVLQKTEEREQQLQSTLQ-QAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYSQLKAKEDVYSQLLAKGRLMLLNRDDSGSGSKTEQSVALLEQKWCLVSTKMEERKAKLEEALALATDFQNSLQDFINWLTLAEQSLNIAPPPSLILAAVLAQIDEHKVFANEVNAHRDRIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRALDDARKRAKQFHEAWKKLVDWLEDAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKALLADDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAFVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKVQLQELSNRWDTVCKLSVSKQTRLEQALKQAEE-------FRTAVHMLLEWLSEAEQSLRFRGALPDDAEALQALIDGHKEFMKKVEEKRADVNAAVGMGEVILGACHPDCITTIKHWITIIRARFEEV--LTWARQHQQRLESALSELVANAELLEELLAWIQWAE-TTLIQRDQEPMPQNIDQVKALISEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGPFIDKSRSNSE---KSLGQAAPPSMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELCP-E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCASMPSSPATPASGAKV-------------------------------------TPSAGSKLKR--PTFHSSRTSLAGDTSNSSSPVSTGAKTTRADPKKAASK--------------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_11 (2099, 2135)

LL
IRQLQRGGIVDTATGHRLSLDEALRKGLVAPNTALLALESLQSFMGLLWPETGEIIPVAD
ALEQGVLSTDLIQEILSKRQLLQAVFVPETTEVLSWQKAVEQGILEGEVAKKLRSTALPD
VMGSVQLSASPSRSRHSQSSPGRSP---TG---PG-----EPLLSSDEER-LVFHLMTHS
YINIHDGHKVLLVDAELNNLTK--TLIQSQ-ENGS---CAQQL---RGFEETEADA--AL
ESEPC-----NGLALQQLELQFAPSKGESEKMLPPRTALENGEVVMGPETLL-------L
EDAEDFLQMEEQKKVSTEQETIR-SETDAEF------------GREQVTFTTT-----DK
HQVKLLMP-EPPSDLDSGLIRETEEMIIEREEESKPP--AEDGVEGPEYQK--RAKLESG
AVV---------VKKSRDRLKIVAE-RSQGVREPEGEAEGAREVYLLKEEVVEDGGEEVV
LPARGEAE--RQSEDVGSVLEVEE--GEQEEATRIEKLGDEGSEKP----APEEQEAEDT
LEKLLRQLQSGGISQEQTGRALLLDEALTAGLVSGHAAVKLMDRMSMFSGFFDSQVGEPL
TTEDVIEEGLMDEKLL-

PF00681 // ENSGT00760000119163_1_Domain_14 (2718, 2755)

QKVLESDKAISGVLDPGNNFVYSIKDAAAVGLLDKET

ENSGT00760000119163_1_Linker_14_15 (2755, 2756)

A

PF00681 // ENSGT00760000119163_1_Domain_15 (2756, 2796)

MRILE
GQVVTGGIVDLKRGKKVSVTLASNLGLIEPRSQTE

ENSGT00760000119163_1_Linker_15_16 (2796, 2819)

LVKLEKASKGKGTDEVSRQKLIN

PF00681 // ENSGT00760000119163_1_Domain_16 (2819, 2858)

LQ
AETCGIVDPETKQPLTVAESVERGLLEKEKAFQLLAKQVADGGIIHHVSGMRLSVDSAMKHGLVSAELCKELRKAESVVLQEFVHPATKEKLSLPQAVSLGLISPEFQREVQEIQAESGSILHPASGQRLALCQAVQQGLVPQQVVERALSSSAMREGIVDPESCMIVPYSELLKKCKIDIESGQRYLEVHPFQAIKDEVTGTRLPCAEAVRLGKLDPLPALRLLQAQADAGGVVEGTVSKRLSLRAAVEQGVLDEAMAKVIAT-----NQLRAGGIVDAPSGKRLTVKEAVGKGLISQKLAAGLQDVRMPE---------EKVG-SEVCKGEKMQLSQEKI-----EG-LSP--EKAEAEVTP-E------HPSVLGTASL-----------PEQTVVA--GAVEKGIPKGSQVRA---AQGKELREKVDGGTEKVE--RLT--------LEKEKLFLGMEVLHREEDGEE----RRRKEFVGAEGVVAGGEGA-VVTSGQ------GERVTR-VVQE-TPAAPR------ESVSVGP----GKGG--MGPGEPPEVGVPAGDELAGERAVKHTERETSHTEGLIDQEKTS-ETELKPTQKQKSKKKK-AKQGSIPGDGAQAEKPP-AEKQLPPSLVSHEI---------------PRKK-----------GEEEHFEPKHESSSEAAAGLARDT-AKHKGGKGKK-IPGKETPREDRVFPVPPEQGET-PEVLKGGVKDGQDSLVKE-RMAQEDTRLET--TLDVS--------STATV-TQELPHDLIIR-----------------------EE-PPEPRETSPVLELGEEKQQEQRAELRADQGAP---------A-PPKSQEETPQPKFEA-LI-SCLILQ--IKFSKKMCLEHDQRLISYLSMLRD--IEMR----IKRVQPAEQNL-AALHDLRQQAEVS-EPGPG------LA--------------GVR------QSFP---------SS------PQLPAPLLASGSFVSGLTLISC---LILQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA----EQNLAALHDLRQQAEALGTELQELSFPVNQELDAVQRIVANPPEEVPEQLLKALEKDAKNLQKSLSSANEILQSQLQNLRGAA-EAEKAKILAQHEALQAKLQELLSWVSVTTGSLDDSDFQQA--T-DASSLSHCLQHYKELKEPLADTKAELDATAFDIQFLISEHAQDLTPQQSRQLLRLLHELQKAFRDLSERVTARVEVLQVCLQQVEQTEQVKLTLQEQQAARAQSLAELSRWLGQAEDTLAEQQ-RAG--GDLPALQQRQSNVKELQRSIHSRAASFAGVLKSTEQFLEENKAKLEPGELAALQQDLQRAKEQYQSLQERTEVAQKELESAVSAAVQQETEKVKAAKELEENSNKIDSLLSWVASLE----------Q--KGGLPEYRPHPVDPGTGTP--AGKSPGDVPDGQAVGADSAAESLDELYERLKAQHQELLSQQQDVILATQSAQALLERQGHSLAGEQRAQLRAQLAELRQQYPAALARSEARLKRAQLLRDELRKFLRDHGEFQAWLEQAEQELEGMCKGDSD-PASLRQLLRRQGSFSEDVISHKG-DLRFVTMSGQKFLD--GDAEDAESQLV---MSRSVVKSKLEDATQRYTRLHSKCSKLGSHLSTLLDHYQQFQEVAESLRTWLQEGEAALGKLLSEAVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQE-TTDAIVSRFQSLSQQLSERSDLLQKSIAQSQSVQESLESLLQSVAEIERSLEKDQPAVLSSASIQDSLATSVKLKQDIARQKSCLEATREMVTRFTAATDSPA-ASALQDKLAQVTEHFGRLCQQQQQREDTLKGLLPKVEQHEQLLEKLQQFTESRTRALASGNQPERDIARFSQHIQELNSEMRQHQEDLATLEHLAEELSSCGFAPSTFQQQEKLQSLKKDFLQLQKVAKDREKDASSCQEQ-------LDEFRNLVGAVRKWLRESESKIPPAETSLGTQELQQRRQQI------QD-----LLEEWKGKGPQVEEIAHRGTLLENLIVEITAPNTPPKAGATL---PSPGGSGGSVNGYHTCK-DLTEIQCDVSEVGRRYQALGAALQERLQQLSALLDSMQQVQEEASSLLQWLESKERSLSQLDASSSPTRTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYPDSPEAANWKKMQEDLNCRWERASQATAARQQKLEESATQLATFQAAEAQLRPWLMEKELMMSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSSSQVQDELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAISTQPDAVKQQLEETSEIRSDLAQLEEEISEAQSLCDDLSVLIGEQYLKDELRKRLETVALPLKGLEDLADLVAAAADRMNRLQTALASSQQFQHMFDELRTWLDDKRCQQAQSQPISAKLERLQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELSRQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAMLSDVEKRRSLLEMLNSAADILTDASQTDEDDVRDEKASINQKMDAITEELQTKTGSIEEMSQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQALEPQVDYLKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKINDCCALMENKLEGIGQFNSRVREMFSQLADLDDELDSMGPIGRDSDSLQSQAEDARAFLGKLQRLKGDIASSEGECKRMLEDEGSPDLLGLKRELETLNKQCSKLAERGRSRQEQVETTLARVEDFYGRLKELSLMTTAAEENEALQWVVGTEVETINQQLADFKQFQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQGLEHDMEEINTRWNTLNKKVAQRVAQLQEALLHCGKFQDALEPLLSWLADTEELISNQKPPSAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIQAEGERIAQAAEPADRDKIVGQLESLGQRWEGLLARAAARQKQLEDILVLAKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQQISRHKAL-------------------------------------------------------------------------------------------------------------NEEIVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSRALRTLEQARQLATKFQSTHEELAGWMSKVEEELAASGAQSPAGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTIKHRVEEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGTCGEEQKAVLQEKTESLVQQYEAVSQLNSERYARLERAQVLVNQFWETYEELNPWIEETQALISQLPPPAIDHEQLKQQQD-DMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQEKYSRAEALYSKIKEEVCQRALALDEAFSQST---Q-------FHDKMEPMLEALGSLSSRLRLPPLIPAEVDKIRECISDNKSSTVELEKLQPSFEALRRRGEELIARSQGPDKDLAAKVIQDKLDQMVFFWEDIKARTEEREMKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNAWENLNKTWKERLEKLEEAMQAAVQYQD----TLQAMFDWLDNAVIKLCNMSPVGTDLSTVKEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGEKIAHRQHKLEAALLALGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DDASSLRNRLEKLNSCWESVLQKTEEREQQLQSTLQ-QAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYSQLKAKEDVYSQLLAKGRLMLLNRDDSGSGSKTEQSVALLEQKWCLVSTKMEERKAKLEEALALATDFQNSLQDFINWLTLAEQSLNIAPPPSLILAAVLAQIDEHKVFANEVNAHRDRIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRALDDARKRAKQFHEAWKKLVDWLEDAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKALLADDTQKLDNLLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAFVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKVQLQELSNRWDTVCKLSVSKQTRLEQALKQAEE-------FRTAVHMLLEWLSEAEQSLRFRGALPDDAEALQALIDGHKEFMKKVEEKRADVNAAVGMGEVILGACHPDCITTIKHWITIIRARFEEV--LTWARQHQQRLESALSELVANAELLEELLAWIQWAE-TTLIQRDQEPMPQNIDQVKALISEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGPFIDKSRSNSE---KSLGQAAPPSMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELCP-E-----LKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQ-SNHSCASMPSSPATPASGAKV-------------------------------------TPSAGSKLKR--PTFHSSRTSLAGDTSNSSSPVSTGAKTTRADPKKAASK-----------------------------------------------------------------------------------------------------------------------

PF00681 // ENSGT00760000119163_1_Domain_17 (2854, 2896)

LLAKQVADGGIIHHVSGMRLSVDSAMK
HGLVSAELCKELRKAESVVLQEFVHPATKEKLSLPQAVSLGLISPEFQREVQEIQAESGS
ILHPASGQRLALCQAVQQGLVPQQVVERALSSSAMREGIVDPESCMIVPYSELLKKCKID
IESGQRYLEVHPFQAIKDEVTGTRLPCAEAVRLGKLDPLPA

PF00681 // ENSGT00760000119163_1_Domain_20 (3042, 3082)

LRLLQAQADAGGVVEGTVS
KRLSLRAAVEQGVLDEAMAKVIAT-----NQLRAGGIVDAPSGKRLTVKEAVGKGLISQK
LAAGLQDVRMPE---------EKVG-SEVCKGEKMQLSQEKI-----EG-LSP--EKAEA
EVTP-E------HPSVLGTASL-----------PEQTVVA--GAVEKGIPKGSQVRA---
AQGKELREKVDGGTEKVE--RLT--------LEKEKLFLGMEVLHREEDGEE----RRRK
EFVGAEGVVAGGEGA-VVTSGQ------GERVTR-VVQE-TPAAPR------ESVSVGP-
---GKGG--MGPGEPPEVGVPAGDELAGERAVKHTERETSHTEGLIDQEKTS-ETELKPT
QKQKSKKKK-AKQGSIPGDGAQAEKPP-AEKQLPPSLVSHEI---------------PRK
K-----------GEEEHFEPKHESSSEAAAGLARDT-AKHKGGKGKK-IPGKETPREDRV
FPVPPEQGET-PEVLKGGVKDGQDSLVKE-RMAQEDTRLET--TLDVS--------STAT
V-TQELPHDLIIR-----------------------EE-PPEPRETSPVLELGEEKQQEQ
RAELRADQGAP---------A-PPKSQEETPQPKFEA-LI-SCLILQ--IKFSKKMCLEH
DQRLISYLSMLRD--IEMR----IKRVQPAEQNL-AALHDLRQQAEVS-EPGPG------
LA--------------GVR------QSFP---------SS------PQLPAPLLASGSFV
SGLTLISC---LILQIKFS--------KKMCLEHDQRLISYLSMLRDIEMRIKRVQPA--
--EQNLAALHDLRQQAEALGTELQELSFPVNQELDAVQRIVANPPEEVPEQLLKALEKDA
KNLQKSLSSANEILQSQLQNLRGAA-EAEKAKILAQHEALQAKLQELLSWVSVTTGSLDD
SDFQQA--T-DASSLSHCLQHYKELKEPLADTKAELDATAFDIQFLISEHAQDLTPQQSR
QLLRLLHELQKAFRDLSERVTARVEVLQVCLQQVEQTEQVKLTLQEQQAARAQSLAELSR
WLGQAEDTLAEQQ-RAG--GDLPALQQRQSNVKELQRSIHSRAASFAGVLKSTEQFLEEN
KAKLEPGELAALQQDLQRAKEQYQSLQERTEVAQKELESAVSAAVQQETEKVKAAKELEE
NSNKIDSLLSWVASLE----------Q--KGGLPEYRPHPVDPGTGTP--AGKSPGDVPD
GQAVGADSAAESLDELYERLKAQHQELLSQQQDVILATQSAQALLERQGHSLAGEQRAQL
RAQLAELRQQYPAALARSEARLKRAQLLRD

PF00435 // ENSGT00760000119163_1_Domain_24 (4411, 4519)

ELRKFLRDHGEFQAWLEQAEQELEGMCKGD
SD-PASLRQLLRRQGSFSEDVISHKG-DLRFVTMSGQKFLD--GDAEDAESQLV---MSR
SVVKSKLEDATQRYTRLH

ENSGT00760000119163_1_Linker_24_25 (4519, 4534)

SKCSKLGSHLSTLLD

PF00435 // ENSGT00760000119163_1_Domain_25 (4534, 4646)

HYQQFQEVAESLRTWLQEGEAALGKLL
SEAVSSDLAVLQKQLAST-K--QLQGDLAEHQVPVEKLQKAARTLLDIQGEPAPDHGHIQ
E-TTDAIVSRFQSLSQQLSERSDLLQKSIAQSQSVQESLESLLQSVAEIERSLEKDQPAV
LSSASIQDSLATSVKLKQDIARQKSCLEATREMVTRFTAATDSPA-ASALQDKLAQVTEH
FGRLCQQQQQREDTLKGLLPKVEQHEQLLEKLQQFTESRTRALASGNQPERDIARFSQHI
QELNSEMRQHQEDLATLEHLAEELSSCGFAPSTFQQQEKLQSLKKDFLQLQKVAKDREKD
ASSCQEQ-------LDEFRNLVGAVRKWLRESESKIPPAETSLGTQELQQRRQQI-----
-QD-----LLEEWKGKGPQVEEIAHRGTLLENLIVEITAPNTPPKAGATL---PSPGGSG
GSVNGYHTCK-DLTEIQCDVSEVGRRYQALGAALQERLQQLSALLDS

PF00435 // ENSGT00760000119163_1_Domain_28 (5028, 5135)

MQQVQEEASSLLQ
WLESKERSLSQLDASSSPTRTETMRAQAEHNKAFLAELEQNSGKIQKVKEALSGLLEKYP
DSPEAANWKKMQEDLNCRWERASQATAARQQKLE

ENSGT00760000119163_1_Linker_28_29 (5135, 5141)

ESATQL

PF00435 // ENSGT00760000119163_1_Domain_29 (5141, 5244)

ATFQAAEAQLRPWLMEKELM
MSVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNQAAQSILTGPGDVSPSSSQVQ
DELQGVNQKWSELTERLNSRSSQIDQAIVKSTQYQELLQGLSEKVKAVGQRLSSQSAIST
QPDAVKQQLEETSEIRSDLAQLEEEISEAQSLCDDLSVLIGEQYLKDELRKRLETVALPL
KGLEDLADLVAAAADRMNRLQTALAS

PF00435 // ENSGT00760000119163_1_Domain_31 (5367, 5471)

SQQFQHMFDELRTWLDDKRCQQAQSQPISAKLER
LQSQIQEQEEFQKSLNQHSGSYEMIVAEGESLLLSVQPGEEKTTLQNQLVSLKTHWEELS
RQAADRHSKLKDCLQKAQKYQRHADDLLPWVEDCKARMAELEVTLDPVQLEATLLRSKAM
LSDVEKRRSLLEMLNSAADILTDASQTDEDDVRDEKASINQKMDAITEELQTKTGSIEEM
SQRLKEFQESFKNIEKKLEGAKHQLEIYDALGPQACSNKNLEKLRAQQEVLQALEPQVDY
LKNLTQGLVEDAPAGSDCSQLLSQAEVAQQDFKAVKQKINDCCALMENKLEGIGQFNSRV
REMFSQLADLDDELDSMGPIGRDSDSLQSQAEDARAFLGKLQRLKGDIASSEGECKRMLE
DEGSPDLLGLKRELETLNKQCSKLAERGRSRQEQVETTLARV

PF00435 // ENSGT00760000119163_1_Domain_34 (5803, 5908)

EDFYGRLKELSLMTTAAE
ENEALQWVVGTEVETINQQLADFKQFQKEQVDPLQLKLQQVNGVGQGLIQSAGKNCDVQG
LEHDMEEINTRWNTLNKKVAQRVAQLQ

ENSGT00760000119163_1_Linker_34_35 (5908, 5915)

EALLHCG

PF00435 // ENSGT00760000119163_1_Domain_35 (5915, 6019)

KFQDALEPLLSWLADTEELISNQKPP
SAEYKVVKAQIQEQ--KLLQRLLDDRKATVEMIQAEGERIAQAAEPADRDKIVGQLESLG
QRWEGLLARAAARQKQLE

ENSGT00760000119163_1_Linker_35_36 (6019, 6024)

DILVL

PF00435 // ENSGT00760000119163_1_Domain_36 (6024, 6236)

AKQFHETTEPVSDWLSVTEKKLANSEPIGTQTAKIQQ
QISRHKAL----------------------------------------------------
---------------------------------------------------------NEE
IVNRKKNVDQAIRNGQALLKQTTGEEVLLIQEKLDGIKTRYSDITAASSRALRTLEQARQ
LATKFQSTHEELAGWMSKVEEELAASGAQSPAGEQIPQFQQRQKELKKEVMEHRLVLDTV
NEVSRALLELVPWRAREGLDKLVSDTNERYKLVSDTIKHRVEEIDAAIQ

PF00435 // ENSGT00760000119163_1_Domain_39 (6350, 6455)

RSQQYEQAADA
ELAWVAETKRKLMALGPIRLEQ-DQTTAQLQVQKAFSIDIIRHKDSMDELFSQRNEIFGT
CGEEQKAVLQEKTESLVQQYEAVSQLNSERYARL

ENSGT00760000119163_1_Linker_39_40 (6455, 6462)

ERAQVLV

PF00435 // ENSGT00760000119163_1_Domain_40 (6462, 6564)

NQFWETYEELNPWIEETQA
LISQLPPPAIDHEQLKQQQD-DMRQLRESIAEHKPHIDKLLKIGPQLKDLNPEEGEMVQE
KYSRAEALYSKIKEEVCQRALALDEAFSQST---Q-------FHDKMEPMLEALGSLSSR
LRLPPLIPAEVDKIRECISDNKSSTVELEKLQPSFEALRRRGEELIARSQGPDKDLAAKV
IQDKLDQMVFFWEDIKARTEEREMKFLDVLE

PF00435 // ENSGT00760000119163_1_Domain_42 (6692, 6797)

LAEKFWYDMAALLTTIKDTQDIVHDLESP
GIDPSIIKQQVEAAETIKEETDGLHEELEFIRLLGTDLIFACGETEKPEVKKSIDEMNNA
WENLNKTWKERLEKLE

ENSGT00760000119163_1_Linker_42_44 (6797, 6802)

EAMQA

PF00435 // ENSGT00760000119163_1_Domain_44 (6802, 6910)

AVQYQD----TLQAMFDWLDNAVIKLCNMSPVGTDLSTV
KEQMNEMKEFKMEVYQQQIEMEKLNHQGELMLKKATDETDRDIIKEPLTELKHLWENLGE
KIAHRQHKL

ENSGT00760000119163_1_Linker_44_45 (6910, 6916)

EAALLA

PF00435 // ENSGT00760000119163_1_Domain_45 (6916, 7020)

LGQFQHALAELMAWLTHTEELLDAQKPINGDPKVIEVELAKHHVL
KNDVLAHQATVETVNKAGNELLESSAG-DDASSLRNRLEKLNSCWESVLQKTEEREQQL

ENSGT00760000119163_1_Linker_45_46 (7020, 7026)

Q
STLQ-

PF00435 // ENSGT00760000119163_1_Domain_46 (7026, 7132)

QAQGFHGEIEDFLLWLTRMESQLSASKPTGGLPETAREQLNAHMELYSQLKAKED
VYSQLLAKGRLMLLNRDDSGSGSKTEQSVALLEQKWCLVSTKMEERKAKLE

ENSGT00760000119163_1_Linker_46_47 (7132, 7138)

EALALA

PF00435 // ENSGT00760000119163_1_Domain_47 (7138, 7240)

TDF
QNSLQDFINWLTLAEQSLNIAPPPSLILAAVLAQIDEHKVFANEVNAHRDRIIELDQTGN
QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSVERGRAL

ENSGT00760000119163_1_Linker_47_48 (7240, 7245)

DDARK

PF00435 // ENSGT00760000119163_1_Domain_48 (7245, 7353)

RAKQFHEAWKKLVDWL
EDAENHLDSELEISNDPDKIKLQLSKHK--EFQKTLGGKQPVYDTTIRTGRALKEKALLA
DDTQKLDNLLGEVRDKWDTVCGKSVERQHKLE

ENSGT00760000119163_1_Linker_48_49 (7353, 7360)

EALLFSG

PF00435 // ENSGT00760000119163_1_Domain_49 (7360, 7461)

QFMDALQAFVDWLYKVEPQLA
EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKVQLQE
LSNRWDTVCKLSVSKQTRLE

ENSGT00760000119163_1_Linker_49_50 (7461, 7465)

QALK

PF00435 // ENSGT00760000119163_1_Domain_50 (7465, 7578)

QAEE-------FRTAVHMLLEWLSEAEQSLRFRGAL
PDDAEALQALIDGHKEFMKKVEEKRADVNAAVGMGEVILGACHPDCITTIKHWITIIRAR
FEEV--LTWARQHQQRLESALSELVANAELLEELLAWIQWAE-TTLIQRDQEPMPQNIDQ
VKALISEHQSFMEEMTRKQPDVDRVTKTYKRKATEPPHGPFIDKSRSNSE---KSLGQAA
PPSMPIISQSETKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELCP-E-----LKE
FANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEM
TAVADIFDRDGDGYIDYYEFVAALHPNKD-AYRPTTDA

PF02187 // ENSGT00760000119163_1_Domain_55 (7839, 7944)

DKIEDEVTRQVAQCKCAKRFQV
EQIGENKYRFF--LGNQ---FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCR-
----------------------ARGRTNLELREKFILPEGASQGMTPFRSRGRRSKPSSR
AASPTRSSSSASQ-SNHSCASMPSSPATPASGAKV-------------------------
------------TPSAGSKLKR--PTFHSSRTSLAGDTSNSSSPVSTGAKTTRADPKKAA
SK----------------------------------------------------------
------------------------------------------------------------
-----