Query Results 

------------------------------------------------------------
---MSLERELRQLYKGKTKAQRSGQLREEAALCHQLGELLASHG--RYAEALREHQQELQ
LLESANDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHHYLELARSLSNHIELQRAWATI
GRTHLDIYDHCQSQDALLQAQTAFGKSLAIVDEKLQGTLPKRELSEMRTRLYLNLGLTFE
SLQQMALCNDYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECAR
IMKKEFMESECCLLLSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQKAVICRTLKHV-LAVVQLQQRLEEAEGS-DPQGAMGICEQLGDLFS
KAGDFPKAAKAYEKQLHFAELLNRPGPELAVIHVSLAATLGDM-KDHRRAVYHYEEELRL
RDGNALEVRADGIQPCPAHTGEGGALEGPAHRLMTGGDSPSEEGQPMPVR----QTEEGH
VQGAGAVLGPSGSAPPKTLESQELVHKSSSEEWDWAENS--WEE----LDADKRAR----
-SVQLQAWEG-RALGSPGD-----EMEEELQS----CRGRRRVT----------------
--------------EWSRRNDVGETMLHRACIEGQLGRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLDIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGQGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLIERGASVTL
RTRKGYSPLETLQQWVKLYYKDLDSETREKAGAMERLLQPHSQFCLP-T-----APHSSL
APQTFLSNHLFDPETSPPSSPCPEPPET-------SQASA------RVSQGQAVPAVARP
RRSRHELASSSS-----SEGEDSMGFPQPIQKRPRHSAPAQQTKARIPG---PT-SNREA
ATASAGRAAYVAAIRGVGSAQSCRRGPGAPRGAGEAP-VP-QAALIPEEECLAGDWLEDD
LLLTQSHRGRRLP---RPQGGGDSTRHCALESGRDKSPVRLQAQARQSQ--LPHLKSRSA
RVAAGGDHSS-AAEPPQSPDVPRASGPSGE-TPVAGQPSGPV--LPPPIRVRVRVQDNLF
LIPVPHR--EAHSVAWLAEQAAQRYYQACGLLPRLTLQKDGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLTDRYRRACQSLEQGEHQQVLQAMERHSSGPLFSACSLALRQAQLT
PLLRALKLHTALRELRLAGNRLGDGCATELLAVLGTVPNLTLLDLSSNHLGPEGLRQLAM
GLLGQTTLQNLEELDLSMNPLGDGCGQALASILQACPSLSTLHLQACGFGPSFFLK--AA
LGSAFQDAKHLKTLSLSYNVLGTSALAQALQSLPTHTLLRLELNSVAAIKN-DTSLVEPL
VRY---------LTKEGCALAHLSLSANHLGDKAVRDLSRCLPLCPSLVSLDLSANPEIS
CASLEELLSALKERPQGLSFLSL-SGCAVQGPLGLGLWDKITAQLQELQLCSRRLSAQDR
DTLRQL-LPSHPGPGACTLDRGPKLFFRRL-

------------------------------------------------------------
---MSLDRELRQLNKAKARAQNSGQLREEAALCHQLGELLASHG--RYSEALQEHQQELR
LRESAEDALGCAVAHRKIGERLAEMEDYSAALQ--YQQHYLELACSLSNHIEVQRAWATI
GRTHLDVYDHSQSQEALLQARAAFEKSLAIVDEKLHRTLPKRELSEMR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

ARLYLNLGLTFE
SLRQTALCNDYFKKSIFLAEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NHLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

YRARYNLGAIHWRQGQHSQAMRCLEGARECAH
TMRKGFMESECCVLISQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQRAAVCQTLKYAVLAVVRLQQQLEESESS-DPQSAMGICEQLGDLFS
KAGDFPKAAKAYQKQLDFAERLDRPGPEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLAATLGDM-KDPRGAVHHYEEELRL
REG

ENSGT00760000119090_2_Linker_4_5 (484, 682)

NALEEAKTWLNIALSREEAGDTYEELAPCFQKALGC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTKARLQELRVDQDEEEE-----EEDGEG----EEASDTMEAS--
-EVELSDSVTEGESQSQDL-----EEEEELRG----CLGRQQVN----------------
--------------KWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

VGETLLHRACIEGQLHRVQDLVRQGHPLSPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAAVDDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAELLIERGASVTL
RT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

RKGHSPLETLQQWLRLYHRDLDRETREKAGAMERRLREAA---SG-R-----APHSPL
APRSLPSDHLFDPETSPSSSPCPGL-------PEASQASA------RVCEAQAVPAVARP
RRSRHQLASS-SS----SEGEDSGGPPGAPQKRPRHSAPAQRAGACTLG---RV-NNRKV
AA--AGRAAYCAAIRGVGSAQSCRPKPGPPRGPGEAP-TP-TAALIPEEECLAGAWLEDD
LPLTQG---RRPPHP-QSRGHRTRRSASESS--SDESPVRPRAQARQSQ--LSRLRSWSA
AVRAGADGSS-AMEPLRSPHVPG----SGD-TPAAGLSSGPV--LPPTIRVRVRVQDNLF
LIPVPHSK-EAHSVAWLAEQAAQRYYQACGLLPRLTLRKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLTDRYRRACQSLEQGEHPQVLQAMERQGVGPLFSACSLALRQAQLT
PLLRALKLHS

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1297)

ALRELRLAGNRLGDGCATELLAALDTLPGLTLLDLSSNHLGPEGLCQLAS
GLVGKATLQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLEELDLSMNPLGDGCSQALASVLRA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPALSTLHLRACGFGPGFLLSHQAA
LGRAFLDAK

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

HLKTLSLSYNILGTTALSQTLQSLPAQTLLHLEVSSMVASKT-DPGLVEPV
VRY---------LTKEGCALAHLNLSANHLGDQAVRDLSRCLPLCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLVSLDLSANPEIS
CAGLEELLSALQERPQGLSFLGL-AGCTVRGPLGPGLWDKIAARLQELQLCSRRLSAEDR
AALGQL-LSGQSDPAARTLDRGSRLFFRRL-

MSLERELRRKSLGGPFL---------------------RGRGGW---GGLGTQ-LRPRTP
PRRPSPPLPPTELSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PDTKIRLQELSIAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGMTSQM-----EEVEELQA----RLGRRKGS----------------
--------------KWNRRNDMGETLLHR----GQLR

PF12796 // ENSGT00760000119090_2_Domain_5 (698, 779)

RVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
CTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
A-FHTPSSLLFDPETSPPLSPCPEPPSNSTRPPEASQAHA------RVSPGQAAPATARP
RRSRHGPASSSSS----SEGEDSAGPPRPSQKRSRCSATAQRVAARTPG---PA-SNREA
VTASTSRAAYQAAIRGVGSAQSR-LGPGPLRGQRKAL-AP-QAALIPEEECLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSST-SG--SDGEESRPRARAKQVR------QSCSV
PVKAG-PSSL-ASEPPGSPSTARASEPSGD-SSAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEGQESCSFWVSSGLGPLVQRCSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPALARTLQRLPARTLLHLELSSVAAGKS-DSDFMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAVGDLCRCLSLCPSLISLDLSANPEIS
CASLEALLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRLLCAEDR
DALRQL-QPSRPGPGECTLDHGSKLFFRRL-

------------------------------------------------------------
---MTLEQELRQLSKAKARAQRNGQLREEAVYCHQLGELLASHG--RFKDALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDVYDHCQSRDALLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLACE
SLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCVLVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPNQRVTVCQSLKYV-LAVIQLQQQLEEAEGN-DLQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPKASEAYQKQLHLAELLNRPDVELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCC-AQQAQRFQLQ----RQILQH
LYTVQLKLQPQEA-HDTEIRLQELSMAKDTEEEEEEEEE---EE----QEASEAPETS--
-ELELSESEGEADGLSQQL-----DEDEELRG----CVGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMERRLQMAS---SG-Q-----ASRSSP
ALQTIPSNHLFDPETSPPSSPSPEPSSYTPRPPEVSPAPD------KVFLEETVSAVSRP
RKTRHRPTSSSSS---SEDE-GDLSPRRPSQKRLRHTTQ--QGEAKTPD---P-PKSRET
ATSSACRTAYRAAIRGVGSAQSRRLVPSLPRGSEEVP-AP-KTALIPEEEYLAGEWLEVD
TPLTRS----A------------RPST--SLSDYERCPTRPRTRVKQSR--PTSLDGWCT
R-TKAGDGSL-TAEPAENPSMPRTSGPNKE-NCAAGQPLLLV--QPPPIRVRVQIQDNLF
LIPVPQS--DVRPVSWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEV
L---AEVISWDLPPLKDRYRRACLSLGQGEHQQVLQAMDHQSSSPSFSACSLALCQAQLT
PLLRALKLHTALRELRLAGNRLGDGCATELLATLGTT

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLQACPVLSTLRLQACGFSPSFFLSHQAA
LGSAFQDAAHLKTLSLSYNPLGAPALARVLQSLPARTLLRLELSSVAASKS-ASGILEPV
IKY---------LTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVS
CASLEELLSALQERSQGLSFLGL-SGCSIQGPLNSDLWDKIFVQLQELQLCSKDLSTKDR
DTLCQR-L---PE-GACTLDQGSKLFFKCL-

-----------------------------MWSASFVVSLRAECWAR-GGSG---PLRRRS
LASLPRLPLSAELSKAKAKAQRSGQLRDEAALSHQLGELLASHG--RYAEALREHQHELQ
LLESIDDPLGCAVAHRKIGERLAELEDYSAALK--HQHRYLELARSLSNHTELQRAWATI
GRTYLDIYDHCQSQDALLQAQTAFEKSLAIVDEKLQGTLTKRELSEMRTRLYLNLGLTFE
SLQQMAPCNDYFRKSIFLAEQNRLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECAR
ALRKELMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

DCCVLISQ-----------------------------IFQDLGDFLAAKRA
LKKAYR

ENSGT00760000119090_2_Linker_2_3 (367, 413)

LGFQKPLQKAAICRTLKYV-LAVVQLQQQLQESEAS-DPQRAMGIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 438)

EQLGDLFS
KAGDFPKAAEAYQKQLYFAELLSRPGPELAVIHVSLAATLGDM-KDHRRAVSHYEQELRL
RGGDALEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHSVQLRLQPQEA-PGTEARLQELSVPRDQEEDE------DKEE----EGDGDTPEAS--
-DVELSESEGDAEGWSQQP-----EEDEELRA----CLGRQTVN----------------
--------------KWNRRNDVGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLGRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAVVDDPGGQGCEGITPLHDALNCGHFEVAELLIERGASVTL
RTTKGHSPLETLQQWVRLYGKDLDSETREKAGAMERLLRAAP---SG-R-----APHGSQ
APHALPRNQLFDPEVSPPSSPCPGP-------PETSQARA------RVSLGQTVPAVTRP
RRSRHKLASS-SS----SEGEDNPGPPRPNQKRPRHSVQPQQDKARTPG---ST-SNREA
AAASAPWV----GVRGVGSAQSCHLGSGPPWGPGEAT-LQ-RPALIPEEECLASDWLEDD
SPLLHSRQDGHLPRS-PGSGDSTGRSASGSG---NKSSSRPRARARQSR--LPRLRSCGA
LVRAGGDGSS-AAEPPWSPDVSRASGPSGEKSPVAGQPSGPS--LPPPIRVRVRVQDSLF
LIPVPHSR-EVHSVAWLADQAAQRYCQACGLLPRLVLRKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLADRYRRACQSLQQEEHQEVLQAMECQGSGPSFSACSLALRQTQLT
PLLRALKLHAALRELHLAGNRLGDGCAAELLAALGTMPGLIL

PF13516 // ENSGT00760000119090_2_Domain_8 (1303, 1319)

LDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AT
GLLGQTTL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGSGQALAFILQACPSLSTLHLQACGFGPSFFLSHQAA
LGSAFQDAKHLKTLSLSYNILGTSALAQALRSLPAHTLQRLELSSVAASKS-DSDLVEPV
VRF---------LTKEGCALTHLSLSANHLGDKAVRELSRCLPLCPSLISLDLSANPEIG
RVGLEELLSALQVRPQGLSFLGL-SGCAVQGPLGLGLWDRITTQLQELQLCSRRLSTEDR
DALRQL-LPGQPGS-ACTLDRGPQLFYRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

TRLYLNLGLTFE
SLKQTTLCHDYFKKSIFLAEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NHLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

FRARYNLGAIHWREGHHSQAMRCLEGARECAR
TMKRRFLESECCLLISQ-----------------------------VLQDLGDFLAAKRA
LKKAFKLGSQKPSQGAVVLRSLKHV-LAVVQLQQRLEEAEGS-NPQDAMAICEQLGDLFS
KAGDFPKAAQAYQKQLHLAELLQRPGPEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLATTLGDM-KQYRQAEHHFQEELRL
RNGNALEEAETWLNIALSREEAGDPYEVLAPCFQKALGC-AQEAQQPQLQ----RRVLRL
LHAVQLTLQPQEA-HATELRLQELGVAEDEEEEEEEE------E----AVASRALEDS--
-EPDLSESEDDVDSRSQ-------QEDEELRG----CLGRQKRD----------------
--------------KWNRRNDMGETLLHRACIEGQLRRVQYLVKQGHPVNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 747)

CGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPG

ENSGT00760000119090_2_Linker_5_6 (747, 751)

GQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAALLIEQGASVTL
RTRKGHSPLETLQQWVKLYCRELDLETRQKAAATERLLQATA---AG-R-----GCHAGG
-----AQNSLFDPEMSPPSSPLPESPSGTPAPSEASQACT------GGSPRRDVPMAARP
RRHRARMVSN-SS----SEDEDDSGRPWPSQKRPRHSA-------------------SEA
AAAGASRAAYQAAMRGVGSAQSR-LGSG-PRCLGKVP-PS-RAALIPEDEYLAGHWLEMD
TPQGHSRQSSRPPPWAQSSGDSR----SGPG------NSTPLAQTQQSH--P-ASPRRGG
PVDAG-AGSL-------------TADPAGG-NLPKGQPSGPV--PPPPLRVRVRVQDNVF
LIPVPHSS-EAPLVAWLAEQAAQRYYQTCGLLPRLTLQKEGALLDPQDPIPDVLQSNDEV
L---AEVSSWDLPPLADRYRRACQSLGQEEHPQVLQAAECQDASPSFSTHCLALRPAQLT
PLLRALKLHTALRELHLAGNRLGDGCAAELLATLATMPSLGLLDLSSNHLGPEGLRHLAM
GLPGRAVLQ

PF07723 // ENSGT00760000119090_2_Domain_9 (1330, 1357)

XLEELDLSMNPLGDSCGQALALLLQAC

ENSGT00760000119090_2_Linker_9_10 (1357, 1390)

PSLHTLRLQACGFGPGFLLSPQEA
LASALRGAA

PF07723 // ENSGT00760000119090_2_Domain_10 (1390, 1414)

RLQTLSLSFNALGTAALTRLLQNLPAHALLRLELGSVIASKT-DLGLVEPV
VGY---------LTKERCVLTHLTLSANHLGDQAVRDLSRCLPLCPSLVSLDLSANPAIS
RASLQELLCVLRERRQGLSFLGL-AGCAVHSPLGASLWDSVGAQLQELRLCSRGLGADDR
EALLRL-QT---G--PGALLRGHKLFLRRL-

---------------------------------------------------MS-------
-----LERELRQLSKAKAKVQRAGHLREEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRESVGDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHRYLELARSLGNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGALAQGELNEMRARLYLNLGLTCE
SLQQTALCNDYFRKSIFLSEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAR
TMKKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCMAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLHFAELLDRPGAERAVIHVSLATTLGDM-KDHRGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQALQH
LHTVQLRMQPQEA-PGTEIRLQELIVAEDEEEEEE-AAA--AAA----TADSGALEAG--
-EVELSESEDDTDGLTQQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
ASRTIPSSLLFDPETSPPLSPCPEPPSNTTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGLASS-SS----SEGEDSTGPPRPSQKRRRCLAMA-------RG---PA-SNREA
AAASASRATYQAAIRGVGSAQSR-LGPGPLRGQSKAL-AP-QAALIPEEECLTGDWLELD
TPPTRSR----RPRP-QSNGDSRGPSST-SG--SDGEEFRPRALAKQVR--LTCLQSCSA
SVKAG-TSSM-ALEPPGSPSTPRASEPSGD-SSAAGQLMGPA--LPPPIRVRIQVQDHLF
LIPVPQSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQLLQAVELQGLGPSFSACSLALHRAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELLSALCTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPDQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRACPLLHSLRLQACGFGPSFFLSHQIA
LGSAFQDAERLKTLSLSYNALGVPALGRTLQSLPARTLLHLELSSVAAIKG-DSGLMEPV
VRY---------LAKEGCALAHLTLSANHLGDEAVRELCRCLSLCPSLISLDLSANPEIS
CASLEELLSALQKRPQGLSFLSL-SGCAVQGPLGLGLWDKIAGQLQELQLCSRRLCTEDR
DALRQL-RPSRPGPGECTLNHGSKLFFRRL-

------------------------------------------------------------
---MSLERELRQLSKAKAKAQRNGQLREEAASCHQLGELLASHG--RYAEALEEHQRELQ
LLESADDALGCAVAHRKIGERLAEMEDYSAALK--HQQRYLELAYSLSNHVELQRAWATI
GRTYLDIYDHSQSRDALLQAQAAFEKSLAIVDEKLEGAVARRELIEMR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

TRLYLNLGLTFD
SLQQAALCSNYFKKSIFLSEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NHLHEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

FRARYNLGTIHWRRGQHSKAMRCLEGARECAR
ALKRGFMESECCLAISQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGSQKPLQREVVCSNLKYAVLKVIRLQQQLEEAKDC-DPESAMGICEQLGDLFS
KAGDFPRAAKAYQKQLHFAELLGRPGPEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLATTWGDM-KEPGRAVHHYEEELKL
RSG

ENSGT00760000119090_2_Linker_4_5 (484, 682)

NPLEEAKTWFNIALSREEAGDAYELLAPCFQKALSC-AQQAQQLRLQ----RRILQH
FQVVQLRLQPQEA-PGTEARLQELDVASQ------------------------ALEAS--
-EVELSESEN------ENP-----EEDEELRG----CLGQQKMN----------------
--------------KWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

MGETLLHRACIEGQLRRIQDLVKQGHPVNPRDYCGWTPL
HEACNHGHLEIVRFLLDHGATVDDPGGSGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALTCGHFEVAELLIERGASVTL
RT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

TKGHSPLETLQEWVRLYSRDLDQETWQKAGAMERLLQTAA---AG-Q-----APQGSQ
VPQAFPSNPLFDPETSPPSSPCPGSPSCDLRPSEASKACA------RLSPRQAAPTVARP
RTSRLGLASSSSS-----ESEDSEGPCQPAQKRPRPSASIRQAPAQMAR---FA-GDRQA
AMASASRAAYQSAVRGVGSAQSRLLGPSQPLGPGVRP-QPPRADLVPEEDCLGEGINPVI
-P--RDARGVVRPAPTPPRQWGTAPRVQTPSGFRVAVSVPPGPGPEQSHLTPIYHKSWNV
EVKAS---TE-ANSAAGSPVTPEASGPGQE-SLLAGQPSGPA--LLPPIRVRVRVQDNLF
LIPVPHST-EAHSVAWLAERAAQRYYQTCGLLPRLTLQKEGALLAPQDAIPDVLQSNEEV
L---AQVTSWDLPPLADRYHRACQSLGQAEHPQVLQAVERQGSGPAFGACSLALRQAQLT
PLLRALKLHT

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1297)

ALRELRLAGNRLGDGCAAELLAALGT

ENSGT00760000119090_2_Linker_7_8 (1297, 1299)

MP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1322)

NLALLDLSSNHLGSAGLHQLAS
G

ENSGT00760000119090_2_Linker_8_9 (1322, 1330)

LPGQAASQ

PF07723 // ENSGT00760000119090_2_Domain_9 (1330, 1357)

SLEELDLSMNPLGDSCGLALASILRAC

ENSGT00760000119090_2_Linker_9_10 (1357, 1390)

PSLSTLHLQSCGLGPSIFLSHQAA
LGDAFRDAE

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

RLKTLSLSYNALGAQALAQALQSLPIHALLRLELSSVVASKR-DAGLMEPM
VRY---------LTKEGCVLSYLTLSGNHLDDKAVRDLSRCLPLCPSLVSLDLSANPEVS
CAGLKELLSALQERPRSLSFLSL-SAAPSQGPLGLGLWDKITAHLQELQLCSLHLAPEDR
DALRHRVLPTQPGLAMCTLDRGAKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNVGLTCD
SLQQAALCHAYFTKSIFLAEQNHLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

FRARYNLGAIHWRRGQHSQAMRCLEGARKCAR
TLKQGSMESECCLLLSE-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQKAVVCRTLKYV-LAVVRLQQQLEESEES-DPRGAMGICEQLGDLFS
KAGDFPKAAAAYQKQLQFAELLNRPGPEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLAATLGDM-KDHRQAVRHYEEELRL
RDG

ENSGT00760000119090_2_Linker_4_5 (484, 682)

SALEEAKTWLNIALSREDAGDAYEVLAPCFQKALSC-AQQAQQPRLQ----RQVLRH
LHAVQLRLQPQEA-LGTEARLQELRAAEDEEDEGDEDDED---D----EGESAALEAI--
-EVELSESEDEVDG-SQRL-----E-EEELQG----CLGRRRVS----------------
--------------KWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

VGETLLHRACIEGQLGRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAAVDDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAQLLIERGASVTL
RT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

RKGRSPLETLQQWVKLYCKDLDGETREKAAAMETLLQAAS---SG-Q-----APHSSL
APPTVPSNHVFDPETSPPSSPSPGP-------PEACQARA------RVSQGLAVPAAARP
RRSRHKLASG-GS----SDGEENPGPPRPPQKRPR-----------MPS---PA-SDGEA
ATASAGWAAYRAAIRSVGSAQRYHLRPSPPRGPGEAP-SP-RAALLPEEECLAGDWLEED
LPLAHGHGGSYPPRP-HSSADGSRHSASGSGSEASA--IRPRARARKSR--LSRLKSWSA
RVRADGACSS-AAEPPRSPDVPRALEPIGG-SPAAGQPLGQA--LLPPIRVRVRVQHNLF
LIPVPQSR-ETHSVAWLAEQAAQRYYQASGLLPRLSLQKEGALLAPQDPISDVLQSNEEV
L---AEVTSWDLPPLTDRYRRACQSLEQGAHQHVLQAMEQQGSGPAFSACSLALRQAQLT
PLLRALKLHS

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1294)

ALRELRLAGNRLGDGCVAELLAALDTVPGLTLLDLSSNHLGAEGLRQLAV
GLQGQPALQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLEELDLSMNPLGDGCGQALASILRA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPLLSTLHLQACGFGRSFFLNHQAA
LRSAFQGAK

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

CLKTLSLSYNGLGASALAQALQSLPARTLLRLELSSVAASKS-DPGLTEPV
VSY---------LTKEGCALEHLGLSANHLGDEAVRDLSRCLPLCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLVSLDLSANPKIS
CAGLEELLSALQGRPQGLSFLGL-SGCAVQGPLGLRLWDNLTVQLQELQLCSRRLSAEDR
DALHQL-LPSQLGPKACTLDRGPKLFFRHL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LKVVQLQQQLEETKGR-DPESAVGICEKLGDLFS
KAGDYPKAAEAYQKQLHFAELLGRPGPELAVIHVSLATTWGDM-KEPGRAVHHYEEELKL
RSGNALEEAKTWYNIAVSREEAGGPYELLAPCYQKALSC-AQEAQQPWLQ----RRILQH
LHTVQLRLQPQEA-PGTEARLQELCVAGDGEEEEEEE------------EDSEALEDS--
-EMELSESENE-------A-----PEEGELRG----CLGQRKGN----------------
--------------KWNRRNDVGETPLHRACIEGQLRRVQGLVKQGHPVNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 747)

CGWTPL
HEACNHGHLEIVRFLLDHGATVDDPG

ENSGT00760000119090_2_Linker_5_6 (747, 751)

GPGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALTCGHFEVAELLIKRGASVTL
QT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

AKGHSPLETLQWWVRLYSRDLDQETWQKACAMERLLQTVA---AG-R-----DPQGSQ
APQAFPSTPLFDPETSPPLSPCPRPPEA-------SQACT------RPSSRRAAPAVAGP
WRGRLGLASSRSS-----DSEDGEGPRQPAQKRXXXXXXXXXXXXXXXX---XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXX------X-X-XXXX--XXXXXXXXXXXXXXXXXXXX--XXXXXXXXX
XXXXXXXXXX-XXXXXXXXXXXXXXXXXXX-XXXXXXXXGLA--LPPPIRVRVRVEDSLF
LIPVPHNT-EAHSVAWLAEQAAQRYHQTCGLLPQLTLRKEGALLAPQDAIPDVLQSGEEV
L---AQVTSWDLPPLADRYHRACQSLGQAEHPQVLQAMELQGSGPTFAACSLALHPAQLT
PLLRALKLHT

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1297)

ALRELRLAGNRLGDGCAAELQAALGT

ENSGT00760000119090_2_Linker_7_8 (1297, 1299)

MP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1322)

SLALLDLSSNHLGPAGLQQLAS
G

ENSGT00760000119090_2_Linker_8_9 (1322, 1330)

LRDQATSQ

PF07723 // ENSGT00760000119090_2_Domain_9 (1330, 1357)

SLEELDLSMNPLGDSCGPALASILCAC

ENSGT00760000119090_2_Linker_9_10 (1357, 1390)

PSLSTLRLRACGLGPSIFLSHQAP
LGGAFRDAE

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1418)

CLKTLSLSYNPLGAQALAQALPSLPFRALLHLELDAVVVSKN-DVELMGPV
AEY---------LTKEGCVLSSLTLSGNHLDDKAVRDLSRCLPLCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLTSLDLSANPEVG
RAALEELLSALQQRLSGLSFLSL-SGCAVQGPKGLGLWDKMTAHLQEMQLCSFSLAPEDR
DRLCHRALASQLGPGMCTLDRGAKLFFRRL-

------------------------------------------------------------
---MSAERELRQLSKAKAKAQRSGQLREEAAACHQLGELLASSG--RYAEALREHQHELQ
LLESVDDALGCAVAHRKIGERLAELEDYSAALK--HQHRYLELACSLSNHTEQQRAWATI
GRTYLDIYDHCQSKDTLLQAQAAFEKSLAIVDEKLQGTLAKRELNEMRTRLYLNLGLTFE
SLQQMAPCNDYFRKSIFLAEQNHLHEDLF

PF13181 // ENSGT00760000119090_2_Domain_1 (270, 294)

RARYNLGAIHWRKGQHSQAMRCLEGARECAR
VLRKELMESECCVLVSQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGFQKPLQKAAVCRTLKYV-LAVVQLQRQLQESEGS-DPQGAMAICE

PF13176 // ENSGT00760000119090_2_Domain_3 (414, 439)

QLGDLFS
KAGDFPKAAEAYQKQLHFAELLGRPGPELAIIHVSLATTLGDM-KDHRRAVSHYEQELRL
RGGDALEEAKTWLNIALSREEAGDAYELLAPCFQKALGC-AQQAQQPRLQ----RQVLRH
LHTVQLRLQPQEA-PTTAARLQELSVPGDEEEDE------EEEK----EGDSDTPEAS--
-DVELSESEGDADGLSQQP-----EEDEELQG----CLGQRRAS----------------
--------------KWNR

PF12796 // ENSGT00760000119090_2_Domain_5 (679, 743)

RNDVGETLLHRACIEGRLARVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAVV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGEGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALTCGHFEVAELLIGRGASVTL
RTSKGHSPLETLQQWVKLYGRDLDSETREKAGAMERLLRAAA---AG-Q-----AP----
--HGLPRSHLFDPEISPPLSPCPGS-------PEP--------------------PGARP
WRNRHTLASS-SS----SEGEDG--PARPTPKRPRHSVPAQQVA-RRPG---SS-SSRDT
AAE------------------------VGPRGLGEPD-PH-RAALIPEEDWLAGDWLEDD
SPLTHSHQDGPVPRP-QGTSRGAPGSGSR-----SPGRPRPRARTRQSR--LPHLTSWNA
PIGARGEGGA-AAEPPRSPNTSRASGPGGD-SPAAGQPSGPP--VPPPIRVRVRVQDSLF
LVPVPHSK-EAHSVAWLAEQAARRYCQACGLLPRLLLRKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLTDRYRRACQSLEEEEHQQVLQAMGCQGSGPSFSACSLALRQTQLT
PLLRALKLHTALRELRLAGNRLADGCAAELLAALGTLPG

PF13516 // ENSGT00760000119090_2_Domain_8 (1300, 1319)

LVLLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1328)

AT
GLREQTA

PF13516 // ENSGT00760000119090_2_Domain_9 (1328, 1350)

LQNLQELDLSMNPLGDGCGQALAFVLQACPSLSTLHLQACGLGPGFLLSHQAA
LGSAFQDATHLKTLSLSYNILGTTALARALQSLPARTLQRLELSSVAASKS-DSGLVEPV
VRY---------LTEEGCA

PF13516 // ENSGT00760000119090_2_Domain_11 (1460, 1479)

LSHLSLSANHLGDKAVKDL

ENSGT00760000119090_2_Linker_11_12 (1479, 1485)

SRCLPC

PF13516 // ENSGT00760000119090_2_Domain_12 (1485, 1507)

CPSLISLDLSANPEIT
RVGLEELLSALQMRPQGLGFLGL-SGCAVQGPLGQRLWHQVAARVQELQLCSRRLAPEDR
TALS-L-LAGPPIPGACTLDRGSRLFFRRL-

------------------------------------------------------------
--------LFLF-----FEMKSCSAAQAGAVLCPR---------LGRYAEALEQHWQELR
LRESAEDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYR

ENSGT00760000119090_2_Linker_2_3 (367, 413)

LGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPRAAEAYQKQLRFAELLNRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLCLPHPQQVLQH
LHTVQLRLQPQEA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTKPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSTGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AR-QAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTTRVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGSGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPGLAL

PF13516 // ENSGT00760000119090_2_Domain_8 (1303, 1319)

LDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPI
VQY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGEGCYGGHACHVCEVVQE----------RPGAGEV
SLATQA-APTHPCASGCPGAASPRPIPH---

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNLGLTFE
SLQQTALCNDYFKKSIFLAEQNHLYEDLFRARYNLGTIHWRGGQHSQAMRCLEGARECAR
VMKKRFMESECCVVVSQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGSQKPLQRTAVCQSLKYV-LAVVRLQQQLEEAEGS-DPQGAMAVCEQLGDLFS
KAGDFPRAAEAYQKQLHLAELLQRPGPELAVIHVSLATTLGDM-KQHRQAEHHYREELRL
RHGNALEEAQTWFNIALSREEAGAAYELLAPCFEKALSC-AQQAQQCQLQ----RQVLRH
LHAVQLRLQPQEA-HGTEIRLQELCVA------------------------SEALEAS--
-EPELSESEDDADGLSQQL-----E-DEELQG----CLGRRKVD----------------
--------------KWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPVNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNHGHLDIVRFLLEHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGQGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLIERGASVTL
RTQKGHSPLETLQEWVKLYCKELDLETRQKAGAMERLLQAT----TA-R-----AAHSAQ
ASRTVPSNRLFDPETSPPSSPCPEPPSRTPGPAEASQAHV------RVSP-----AAARP
RRSRHWVASS-SS----SEDEDGSGHPRPSHKRPRHSP-------------------SEA
AAASAGRAAYQAAIRGVGSAQSHRLGSG-SRGLGRAP-TS-RAALIPEEEYLAGDWLEQD
IPQAPSRQSGRPARP-QGNGDSRRPSAAGQD--SEECPTRPQ--AQQTR--PACPEGWGA
PRSAG-DSGL-AAEPPRSPSTPRASGP----------PSGPV--PPPPLRVRVRVQDNLF
LIPVPHSS-EAPPVAWLPSRPPSATTRPAACCPGSPFKRRG-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---MTLEQELRQLNKAKARAQRNGQLREEAVYCHQLGELLAGHG--RFKEALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAASLSNHTELQRAWATI
GRTHLDVYDHCQARDALLQAQAAFEKSLAIVDEKLEGTLTQRELSEMRARLYLNLGLTFE
SLQQTALCHDYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCVVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYKLGSQKPVQRVAVCQSLKHV-LSVIQLQQQLEEAEGN-DPQRAMAICEQLGDLFS
KAGDFPKASEAYQKQLHFAELLNRPDVELAVIHVSLATTLWDM-KDHRKAVHHYEEELRL
RKGNAPEEAKTWFNIALSREEAGDVYELLAPCFQKALSC-AQQAQLFQLQ----RQILQH
LYTVQLKLQPQDA-PSTEIKLQKLSMAKDTEEEEEEEEE---EE----DEASEALETS--
-ELELSESEDDADSLSRRL-----EEDEELQG----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTKKGLSPLETLQQWVKLYFRDLDLETRQKAASMERRLQLAS---SG-Q-----VPHGSS
ALQSIPSNHLFDPETSPPLSPCAELSLCTPRLPEVSPAPA------KVFLEETVSAVSRP
QKNRQRPTSSSSS---SE-DEDSVGPCRPSQKRLRPSTKAQQDEAQTPE---PSSKSRET
ATAIACRSAYQAAIRGVGSAQNRRLVPGLPRSSDEVP-AP-KAALIPEEEFLAGDWLELD
TPVSLR----S------------RPSA--SGSDYERCSVRRRAGAKQTR--LTCLNDWGT
R-TKAGDGSL-AAEPPESPSMPRTSGPTRE-NCTAGQPLLLV--QPPPIRIRVQIQDNLF
LIPVPHS--DVHSVAWLAEQAAQRYYQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHRQVLQAVEQQSSSPSFSACSLALCQAQLT
PLLRALKLHTMLRELRLAGNRLGDTCAPELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1319)

PNLTLLDLSSNHLGQEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AE
GSSGQTAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQAL

ENSGT00760000119090_2_Linker_9_10 (1350, 1390)

ASLLRACPMLSTLRLQACGFSPSFFQSHQAA
LGSAFQDAE

PF13516 // ENSGT00760000119090_2_Domain_10 (1390, 1403)

HLKTLSLSYNTLGAPALARVLQNLPAHALLRLELSSVAASKS-NLSLMEPV
IKY---------LTKEGCALTHLTLSANYLSDKAVRELSRCLPCCPSLVSLDLSANPEVS
CASLEELLSALQERPQGLSFLGL-SGCSIQGPLSSDLWDKIFVQLQELQLCSRHLSTGDR
DALGAR-L---PA-SACSLDQGPKLFFKCF-

------------------------------------------------------------
---MTLEHELRQLHKAKARAQRSGQLREEAACCHQLGELLAVHG--RFLEALEEHQQELQ
LLESAKDTLGCAVAHRKIGERLAEMEDYSAALK--HQHCYLELAGSLSNHTELQRAWATI
GRTHLDIYDHCQSKEALLQAQSAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTFE
SLQQTALCHDYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCMVLSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRTAVCQNLKYV-LAVVQLQQQLEEAEGS-DPQPAMVICEQLGDLFS
KAGDFPKAAEAYQKQLHFAELLNRPDLELAVIHVSLATTLGDM-KDHRQAVHHYEEELRL
RKGNALEEAKTWFNIAVSHEEAGDAYELLAPCFQKALSC-AQQAQRLQLQ----RQILQH
LHTVQLKLQPQDA-PDTETRLQELSMVKENEEEEEDEEE---EE----AEASEALETS--
-ELELSESEDGADSLPRQL-----EEDEELRG----CLGRRKVNKVRTRYFVPPCARSIS
CPSHLCPEPGHLYLQWNRRN

PF12796 // ENSGT00760000119090_2_Domain_5 (681, 780)

DMGETLLHRACIEGPHF------------------LW---
-------FPEIVRFLLNHGAIVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASTTL
RTKKGHSPLETLQQWVKLYFRDLDFETRQKAAAMEKRLRA-S---SG-P-----APHGSP
APQTIPSNHLFDPEISPSSSSCPEPSLHTPGPPEGSLAPV------KVSPQNAMPAVARP
RKSRHRQASNSS----SSEEEDNRGPHKPSQKRPRHPAMAQQDEACKTG---PA-SNRET
AIMSTGRAAYQAAIRGVGSAQSRRLGPNLPWSSDEVP-VT-QEALIPEEEYLAGDWLELD
APLTRSSKA-S---------------T--SGSDSERCSVRPRSRAKQSR--LSHLESWCA
V-DKTGDGSL-AAEPSGNTITMRALGPSRE-NPTAAQPSVLV--QAPPIRVRVQVQDNLF
LIPVPHSD--THSVAWLAEQAAQRYYQTCGLMPRLTLRKEGALLAPQDPIPDVLQSDDEV
L---AEVTSWDLPPLTDRYRKACQSLGQGEHQKILQVMECQSSGPSFSACSLALCHAQLT
PLLRALKLHTVLRELRLAGNRLGDGCAPELLAALGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1319)

PNLVLLDLSSNHLGQEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AG
GPLGRVAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCCQALASLLRVCPLLSTLRLQACGFGPSFFLSHQAA
LGSVFQDAEHLKTLSLSYNALGAPALARVLKSLHTHTLLHLELGSVAADKS-DLNLMEPI
VRY---------LTKEGCALTHLTLSANYLSDKAVRELSRCLPCCPSLISLDLSANPEVS
CTSLEELLSALQERRQGLSFLDL-SGCNIQGPLGPSLWDKMTLQLQGLQLCSRGLHTEDR
DAICQR-V---PGPNACTLDQGSKLFFLQRP

------------------------------------------------------------
---NSLSNAIQKLQKDKEKAQRKGDLKEEAALCNQLGSILARHG--QFQEALEEHRLELR
LLEGLGDVIGCAVAHRKIGECLAELESYEAALK--HQRRHLDLARSVSSDIEQQRAWATI
GRTYMFMAEGQQSSSALEEAEKAFMKSLAIVEEKLEGEVSQREVSEMRARLYLNLGLVYD
GLKDPAKHTYYIKKSIYISEQTQLLEDLY

PF00515 // ENSGT00760000119090_2_Domain_1 (270, 296)

RAYYNMGNIHLREGQHSKAMRCLERARECAC
KMKEKHMESECCAGIAQ-----------------------------VLLSLGDFVAAKRS
LKKAYRMGSQQPQQRESVCHNLRYV-SKVTRLQQALEEAEASCDRGAALALSEQLGDLFS
KAGDYQRSLEAYKKQLGYAQALKRPPHELAVIHVSLAATFGDL-KDHAQALHHYQEEL-L
RKGNLLEEGKTWLSIALAKEEAKESYEELEPCFRKALQY-AEKAFDPRLQ----HQILQH
LHACQQRAGRPEA-AETMGRLQDLRRMEGWHSDGEISEEEEEEESCDRSQATRENETSSL
GKWPLADGEFSQEA-RLDG-----EEEEDLEGYNKTVSGQRRTK----------------
--------------KWNQRNDKGETLLHRACIDGNLRRVQFFVEKGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNHGHLEVVRLLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDAGGPGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFDVAEMLVQRGASTLL
RDGKGQTPLDTLHQWMHLYGRDLDQETRERCKAMEGLLKKAM---AG-R------ASKTQ
VQRETPSSQLFDAEFSESQGSGPQGSARTTTSPRQSQV----------------------
---------------DPELDEDCMVPLRPVKKRQRLLSQSL--------------AREEG
GPITTAPSEYAAAMRGVGSALSR----GPPSSDRPAR-PSPAPALIPTEEYIDDDWLDDD
LGVNTVSRKRGRQSPLGSACEESQEDEEEEEGESDA---GPPCAAPKV----PTKRRRAS
NQPSSESQSL-ELSPPRDPN-------------CLNYPQ--APAPPPPIRVRVRVQDNVF
LIPVPHSDREGCLVSWLAEQASQRYYQACGLLPLLTLKKEGALLAPQDRIVDVLQSNEEV
L---AEVQSWNLPPLVERYRKACRSLAAEEHRLLLRMLERQESGPSFSVAGVSLRGPRLT
PLLRALKLQASIRQLCLSGTGLGDDSAEELLASISTMPALRQLDLSSNRLGPRGFASSPQ
GSPETLFSRTLEELDLGLNPLGENSGPSLAALVQAAPLLKALRLQACGLTSASLQHHQPL
KGT--EAGLHWGSLALSHNGLGPEGLDLVLRSLPCQRLSRLDLGSVGRRAAEQKPLWKPL
AAY---------LAQEGCALSHLTFSGNQLNDNAVAELAR--------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
---MTLEQELRQLRKAKARAQRNGQLREEAVYCHQLGELLAGHG--HFMEALEEHRQELH
LLESVQDTLGCAVAHRKIGERLAEMEDYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDVYDHHQSRDALLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTFE
SLKQTALCNDYFKKSIFLAEQNSLYEDLFRAQYNLGAVHWRGGQHSQAIRCLEGARECAR
AMKMRFMESECCVVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPSQRVAVCQSLKYV-LAVIQLQQQLEEAEGK-DPQRAIAICEQLGDLFS
KVGDFPKASEAYQRQLHFAERLNRPDLELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEANTWFNIALSREEAGDAYELLAPCFQKAFSC-AQKAQRFQLQ----RQILQH
LHAVQLKLQPQEA-PDTETKLQELSMAKDTEEEEEE-EE---EE----EEASEALETS--
-ELELSESEDDVDSLSQKL-----EEDEELQS----CLGRRKAN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGATVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTKKGLSPLETLQQWVKLYFRDLDLETRRKAACMERRLQVAS---SG-Q-----APHGSP
AVQTIPSNHLFDPETSPPSSPCPEASSCTPRPPEASPAPA------KVFLEETVAAVSRP
RRNRHRPTSSSSS---SE-DEDNVGHCRPSQKRLRHSLKAQPDEAQTPD---PSSKSRDT
ATSSACRAAYQAAIRGVGSAQSRRLVPSLPRASDEVP-TP-KAALIPEEEFLAGEWLELD
TPLTRS----S------------RPST--SGSDYERCPVRHPTRAKQSR--LTCLDGWGT
R-TKARDGSL-ATEPPESPSMPRTSGPNRE-NCTAGQPLLLV--QPPPIRVRVQVQDNLF
LIPVPHSS-DVHSVAWLGEQAAQRYYQTCGLLPRLTLRKDGALLAPHDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAMEQQSSSPSFSACSLALCQAQLI
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1284)

HTTLRELRLAGNRLG

ENSGT00760000119090_2_Linker_7_8 (1284, 1298)

DGCAPELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLSQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPMLSTLHLQACGFSAGFFQSHQAA
LGSAFQDVEHLKTLSLSYNTLGAPALARVLQSLPAHTLLRLELSSVAASKS-NLSLVEPV
VKY---------LTKEGCALAHLTLSANSLCDKAVRELSRCLPCCPSLVSLDLSANPEVS
CASLEELLSILQERPQGLSFLGL-SGCSIQGPLNSDIWDKIFMQLQELQLCSKRLSTRDR
DAVCRR-L---PA-SACSLDQGPKLFFKCL-

------------------------------------------------------------
---MNEEREIRQLKKAKAKAQKNGQLKEEAVLCNQLGEILASHG--SYREALAEHRQELQ
LLESTGDVLGCAVAHRKIGERLAELEDYTAALT--HQHRHLELAQSLSSHIEQQRAWATI
GRTYLASYDHSQSVDALLQAQAAFEKSLAIVDEKLERVLTQQELSEMRTRLYLNLGLTFD
SLKQPALCSDYIKKSIFLSEQNHLYEDLYRARYNLGTIHWRAGEHSKAMRCLEGARECAR
IMKRKFMESECCVVVAQ-----------------------------ILQDLGDFVAAKRA
LKKAYRLGSQQPKQRHTICRNLKYV-LKVMSLKQRLEEAESS-DLHGALSICEQLGDLFS
KSGDFPKAVEAYQKQLQFAKSLKIPNQELAVIHVSLAATFGDL-KNYSQAVEHYEEELRL
RRGNPLEEAKTWLNIALSKEEGGKPYEELEPCFQSALHC-SQEAKKPWLQ----RQILQH
LHALQLKYQPHEA-PNTSSKLQELSSTEDGSPSK-DISE---EDEEEELENSEALEDS--
-EVELSESENEDNDSLQ-------PGEEEMESYGQTGPGRRKVN----------------
--------------KWNRRNDMGETMLHRACIDGQQRRVRDLVEQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNHGHLEIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGPGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLVERGASVTA
KNSKGHNPRETLRQWVKLYSKDLDQETRQKAQDMEKLLLQTAVRKLHQTTSVVPASQGSH
TPQTIQTNPLFDPETSPTSSPIRSSHFLATSKAQHPFAQNRSFNKPLTSPELGGLGFSRP
QSYQAG------DGASSSEEDVDTVPFQPFKKRPRLLNMEQRAEGATLH---PT-ENIDS
DVASASRAVYQAAIRGVGSAQ--HLFKAITKGPSETS-IA-QAALIPEEEYLDGDWLEED
MDSHCVRRKRSHCFPDSGSDC-----TSGPDSNS-GTCTSSKSRSRQSRLT--HIVDRTV
L---GRTSGS-SNLTGENTSNSRVSGASGE-SPSPGYLPCSA--GPPPIRVRVRVQDNIF
LIPVPHSGSKGHPVSWLAEQASQRYYQTCGLLPRLTLKKEGALLAPEDLITDVLQSNEEV
L---AEVVSWDLPPLTDRYRKACQSLREAEHQLVLQALEQQGSGPSFSVCSLALHPAQLT
PLLRALKLHTSLRELRLVGNRLGDNTAVELLATVSTMPGLTLLDLSSNHLGPDGLHQLAT
SLQNQNTFQNLEELNLSMNPLGDGCSQALASLLQACPVLSTLHLQACGFSSNFLQSHQHT
MDSALQGAQHLKILSLSYNTMGVPALTRVLQILPHSVLARLELGSVMVNKN-SLGFMEPL
IRY---------LTQDGCALTHLTLSGNYLNDEAIRSLTRCLSICPSLISLDLTANPKVS
RVSLEEILSTLQERNSGLDFLGL-AGCSIEGPLGSCTWDKITSQLQQLQLCSSKLRLTDH
QVLCQQ-LAYKQDPASFILTHHHKLFFEGH-

---------------------------------------------------MS-LDR---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AP-QAALIPEEECLARDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGSGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLPLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLGAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

---------------------------------------------------MS-LDR---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQTQHQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMESECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHAVQLRLQPQEA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLEIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGQGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIWGVGSAQSR-LGPHPPRGQSKAL-AP-QAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQGCSA
PVKAG-PSSL-SSEPSGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAM
GLPGQATLQSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LSSAFQDAEHLKTLCLSYNALGAPSLARTLRSLPARTLLHLELSSVAAGKG-DSGLMEPI
VQY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

---------------------------------------------------MS-LER---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLHNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVD-ELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTKTRLQELSVDEDEDEEEEEEEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
ASLTLPSSLLFDPETSPPLSPYPEPPSNSTRPPEASQAHA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLATAQQVAARTPG---PA-SNNEA
ASASTSRAAYQAAIRGVGSAQSR-LGPRPPRGQSKAL-AP-QAALIPEEECQAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-ASEAPGSPSTARISEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDMPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPNFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPV
VQY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLDLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LAVVLLQQRLEDAEGR-DPQGAMAVCEELGDLFS
KAGDFPRAVKAYQKQLQLAELLNRPGPELAVIHVSLATTLGDM-KEHRQAVHHYEQELGL
RRGNTLEEAKTWLNIALSREEAGDAYELLVPCFQEALSC-AQQAQRPQLQ----RQVLQH
LRDVQLRLQPQEA-PATEARLQELGLAEKEDSEEGDTEEEDAE-----EEDAKALEASGX
XXXXXXXXXXXXXXXXXXX-----XXXXXXXX---XXXXXXXXX--XXXXXXXXX-----
--------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX-X-----XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXX------XXXXXXXXXXXXXX
XXXXXX--XX-XX----XXXXXXXXXXXXXXXXXXX--XX--XXXXXXX---XX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX-XX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-X--XXXXXXXXXXXX--XXXXXXXXXXXXXXXX----XXXXXXX
XXXXXXXXXX-XXXXXXXXX-XXXXX-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XIPVPHGS-EAHSVAWLAEQAAQRYHQTCGLLPRLTLRKEGALLAPQDPISDVLQSNEEV
F---AEVTSWDLAPLADRYRRACQSLGQGEHRQVLQAVERQSAGPSFSACLLALRQAQLV
PLLRALKLHS

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1294)

GLRELHLAGNRLGDGCAPELLAA

ENSGT00760000119090_2_Linker_7_8 (1294, 1299)

LGTMP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1326)

NLVLLDLSSNHLGPEGLRQLTA
GPLGQ

ENSGT00760000119090_2_Linker_8_9 (1326, 1330)

AALQ

PF07723 // ENSGT00760000119090_2_Domain_9 (1330, 1357)

NLEELDLSMNPLGDSCGQALASLLRACPLLSTLHLQACGFGPSFL-SHPAA
LGSAFRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXCLPLCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLTSLDLSANPGIS
GTSLKELLSSLQERMQGLSFLGL-SGCAVQGPLSRGLWDKIFTQLQELQLSNRHLCPEDR
DLLHQL-LCSGPDPNVCT-DRGCRLFFLCF-

------------------------------------------------------------
---MTLEQELRQLSKAKTRAQRNGQLREEAAYCHQLGELLASHG--RFKDALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDIYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCE
SLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCVLVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPNQRVTVCQSLKYV-LAVIQLQQQLEEAEGN-DLQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCC-AQQAQRFQLQ----RQILQH
LYTVQLKLQPQEA-RDTEIRLQELSMAKDTEEEEEEEEE---EE----EEASEAPETS--
-ELELSESEDDADGLSQQL-----EEDEELQG----CVGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMEKRLQMAS---SG-Q-----ASRSSP
ALQTIPSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPA------KVFLEETVSAVSRP
RKTRHRPTSSSSS---SEDE-DNPSPCRPSQKRLRHTTQ--QGEVKIPD---P-PKSRET
ATSSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVP-AP-KTALIPEEEYLAGEWLEVD
TPLTRS----G------------RPST--SVSDYERCPARPRTRVKQSR--LTSLDGWCA
R-TQAGDGSL-NAEPAENPSVPRTSGPNKE-NYAAGQPLLLV--QPPPIRVRVQIQDNLF
LIPVPQS--DIRPVAWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLKDRYRRACLSLGQGEHQQVLHAMDHQSSSPSFSACSLALCQAQLT
PLLRALKLHTALRELRLAGNRLGDACATELLATLGTT

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSSSFFLSHQAA
LGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPACTLKRLDLSSVAASKS-NSGIIEPV
IKY---------LTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVS
CASLEELLSALQERSQGLSFLGL-SGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKDR
DSVCQR-L---PE-GACTMDQSSKLFFKCL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

TRLYLNLGLTFD
SLKQPALCSDYIKKSIFLSEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NHLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 293)

FRARYNLGTIHWRGGQHSKAMRCLEGARECAR
VLKRKFMESECCVVVAQ-----------------------------ILQDLGDFVAAKRA
LKKAYRLGSQQPRQRHTVCRSLKYV-LKVVSLQQKLEEAEHS-DLHEA

PF00515 // ENSGT00760000119090_2_Domain_3 (409, 442)

LGICEQLGDLFS
KSGDFPKAAEAYQKQLQFAKS

ENSGT00760000119090_2_Linker_3_4 (442, 450)

LKIPTQEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLAATFGDL-KNYSQAVEHYEEELRL
QRG

ENSGT00760000119090_2_Linker_4_5 (484, 682)

NPLEEAKTWLNIALSKEEAGKPYEELEPCFQSALHC-SQEAKKPWLQ----RQVLQH
LHAVQLKHQPLKA-PSTNSKLQELSCAEGWSPSK-DIME---EEEEEELENSEALEDS--
-EVELSESENEDGGNLQ-------SGEEEMESYGQTGPGRRKVN----------------
--------------KWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

MGETMLHRACIDGQQRRVRDLVEQGHPLNPRDYCGWTPL
HEACNHGHLEIVRFLLDHGAAVDDPGGPGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAELLIERGASVTA
CT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

RRGHSPRETLRQWIKLYGRDLDQETRQKAQAMEKLL---------QTASLGQASQGSL
TSQTIQTNSLFDPETSPSSSPSGLPPGHIRAPAS-PXXXXXXXX----XXXXXXXXXXXX
XXXXXX------XXXSSSEEDDDMVPFQPVKKRPRLS-TGHLSEGATLY---SP-ETTDS
DVASTSRAVYQAAIRGVGSAQARRP------DHSKTP-MT-QAALIPEEEYLDGDWLEDD
M-SLCVHRKRNHCLPENGSDC-----TSWSDSNGGK------PRSREPTH---SNCGQDS
A---GQNKGS-SNLTEENPSVSRVSGASGE-SPSAG---CSA--APPPLRVRVRVQDDVF
LIPVPQSS-ERHPVSWLADQASQRYYQTCGLLTWLILKKEGALLAPEDLITDVLQSNEEV
L---AEVVSCDVTPLTDRYRKVCQNLREAENQLVLQALEQQSSGSSFSACSLALRPAQLT
PLLRALKLHT

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1294)

SLRELHLVGNRLGDNIAVELLAT

ENSGT00760000119090_2_Linker_7_8 (1294, 1299)

ISTMP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1325)

GLTLLDLSSNHLGADGLHHLAT
GFPN

ENSGT00760000119090_2_Linker_8_9 (1325, 1330)

HNTFQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLEELNLSMNPLGDGCAQALASLLQTCPAISTLRLQACGFSSNFLRNHQHT
MNSALQGARHLKILSLSYNTLGVAALARALQCVPHRVLAQLELGSVTANRN-SSGLMEPM
IKY---------LTQEGC

PF00560 // ENSGT00760000119090_2_Domain_11 (1459, 1481)

ALTHLTLSGNYLSDEAVRNLSRCLPICPSLISLDLTANPKIS
CASLEDILSTLQERNSGLDFLGL-SGCSIEGPLNSCTWEKITSQLRELQLCCSKLKPTDH
QALGQQ-LACKQGPASCILTHHHKLFFGCH-

------------------------------------------------------------
---MNLERELRQLSKAKAKAQRSGQLREEASVCHQLGELLASHG--CYAEALREHQQELQ
LLETADDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHRYLELACALSNHVEQQRAWATI
GRTHLDIYDHHQSQDALQQAQDAFEKSLAILDEKLQGSLPKRELSEMRTRVYLNLGLTCE
SLQQVALCSAYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECAR
VLKQGFLESECCLLLSQ-----------------------------VLLDLGDFLAAKRA
LKKAYRLGSQKPLQKASVCRTLKYV-LAVVQLQQRLEESEES-DPEVAMGICEQLGDLFS
KAGDFPKAAAAYQKQPPFGALPTGPGPGLAVIHVSLAATLGDM-KDHRQAVHHYEAELRL
QEGNPLEEAKTWLNIALSREEAGDTYEVLALCFQKALGC-AQLAGQPQLQ----RQILRH
LHAVQLRLQPQEA-PGTETRLQELQAAGDED-ERDGEDE----------EDDDALEAT--
-ELELSESEDEADA-SPPL-----EEDEELRG----CLGRQRVN----------------
--------------KWSRRNDVGETLLHRACIEGRLGRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLDIVRFLLDHGAPV

ENSGT00760000119090_2_Linker_5_6 (743, 751)

DDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 782)

DGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGHSPLETLRQWVKLYGKDLDSETQEKAAAMGRLLQAAS---LG-R-----APHSSQ
APQTLPSNHLFDPETSPPSSPCPGT-------PEVCEAST------RVSQGLAVSPVARP
RRSRHKVASS-SS----SEGEDKAGPSHPTQKRPRHTGPTLQTKAPMPR---PA-SDREA
ATTSASWAAYRVAMHGVGSAQTCRLGPSPLRGPSETP-IP-QAALLPGAPAQPAPRAV--
-GMAADTVPPAQAAT-QHAG-------PGPRPGRAGCPISRAGAHQPEP--RPSRGSRSP
PARADRADSP-ATELTRSPDVPRAVAPAGE-NPTAGQL--LV--LPPPIRVRVRVQDNLF
LIPVPH-R-EAHSVAWLAEQAAQRHYQASGLLPRLSLQKEGALLAPQDPIPDVLQSNEEV
L---AEGFMGDLPPLKDRYRRACQTLEQGEHQQVLQAVEHQGSAPTFSACSLALCQAQLT
PLLRALKLHSALRELRLAGNRLGDGCVAELLATLDTVPGLTLLDLSSNHLGPDGLRQLAA
GLLGQTTLQNLEELDLSMNPLGDGCGQALASVLRACPVLCTLHLQACGFGPSFFLSHQAT
LGSAFQDTKCLKTLSLSYNGLGPTALGQVLGSLPAHSLLRLELGSVATGKS-DLGLMEPV
VRY---------LSQEGCVLEHLSMSANHLSDKDVRALSRCLPLCPSLVSLDLSANPEVS
SAGLEELLSTLQKRPQGLSFLQREGGCAVQGPLGLDLWDKVVAQLQELQLCTRRLSAEDR
DALHQL-LPSQLGPRVCTLDQGPKLFFRHL-

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVD-ELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQH------------------------------------
---------------LRFAELLDRPSAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RGGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLQEFSVDENEDEDEE-EEA--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRMGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
ASLTIPSSLLFDPETSPPLSPCPEPPSNSTRPPEASQAHA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPMRLSQKRPRCLATAQQVAARTPG---PA-SNNEA
AAASTSRAAYQAAIRGVGSAQSR-LGPRPPRSQSKAL-AP-QAALIPEEECQAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSRL-ASEAPGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQAL

ENSGT00760000119090_2_Linker_9_10 (1350, 1390)

ASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAE

PF13516 // ENSGT00760000119090_2_Domain_10 (1390, 1404)

HLKTLSLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPV
VQY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLDLWDKIAAQLRELQLCSRRLCAEDR
EALRQL-RPSRPCPGECTLDHGSKLFFRRL-

-------MPRASGRHFPE------------CRRGARPRRRAGSLDPAATLSMS-------
-----LERELRQLSKAKAKVQRAGHLREEAALCHQLGELLAGHG--RYAEALQQHWQELQ
LRESVGDRLGCAVAHRKIGERLAEMEDYPAALQ--HQHRYLELARSLGNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRARLYLNLGLTFE
SLQQTALCNDYFRKSIFLSEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAR
TMKKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCMAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRATICQNLQHV-LAVVRLQQQLEEAEGN-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLHFAELLDRPGAERAIIHVSLATTLGDM-KDHLGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRMQPQEA-PGTEIRLQELIVAEDEEEEEE--EA--AVA----TVDSGALEAS--
-EVELSESEDDTDGLTQQL-----EEDEELQG----RLGQRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGATVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAT---SG-Q-----DPHSSQ
ASRTIPSSLLFDPETSPPLSPCPEPPSNTTRPPEASQARA------RVSLGQVAPAVARP
RRSRHGPASS-SS----SEGEDSTGTPQPSQKRPRCSATAQQVAAQTPG---PA-SNREE
AAASASRATYKAAIRGVGSAQSR-LGPGPLWGQSKAL-AP-QAALIPEEECLTGDWLELD
TPPVRSR----RPRS-QSNGDSRRPSST-SE--SDSEECRPRALAKQVR--LTCLQSCSV
SVKAG-TNSM-ASESPGSPSTSRASEPSGD-SSAAGQLVGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQLLQAVELQGLGPSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELLGALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPDQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGNTCGQALASLLRACPLLSTLRLQACGFGPSFFLSHHIA
LGSAFQDAERLKTLSLSYNTLGVPALGRTLQSLPARTLLHLELSSVAASKG-DSGLMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAVRELCRCLSLCPSLISLDLSANPDIS
CASLEELLSALQKRPQGLNFLSL-SGCALQGPLGLGLWDKIAEQLQELQLCSRRLCAEDR
DALRQL-RPSRPGPGECTLNHGSKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------MENFTEALQ--HQHHYLDLARSLSNHTEQQRAWATI
GRTHLDIYDHQQTEDALLQAQAAFEKSLAIVDEKLQGTLAKRELSEMRTRLYLNLGLTFE
SLRQAALCSAYLKKSIFLAEQNHLYEDLFRARYNLGAIHWRQGQHSDAMRCLEGARECAR
LLKQGFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVLISQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQKAVVCRTLKYV-LAVVQLQQQLEECEGH-DPQSAMSICEQLGDLFS
KAGDFPKAAEAYQKQLQLAELLRRPGPELAVIHVSLAATMADM-KDPRQAVHHYQEELRL
RDGNALEEAKTWLNIALSREEAGDAYELLAPCFQKALRC-AQQAQQPRLQ----RQVLRH
LHTVQLRLQPQAA-PDTEARLQGLSVAEDKENEGDDEDEGDDED----EGDENIPEAV--
-EVVLSESESEADSQSQQL-----EEDEELRG----CLGR--------------------
--------------RWNRRNDVGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLGRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAAVDDPGGQGCEGITPLHDALTCGHFEVAELLIERGASVTL
RTRQGHSPLETLQQWERLYRKDLDLETREKVAAMERLLQAAS---SG-R-----APHGSL
APQTLPSNSPFDPETSPPSSR--EP-------PEACQASA------TVSQGLAVPAVARP
RRSRHKLASS-SS----SEGEDGTGPPRPAQKRPRHSAPAQSAKAWTSG---PA-DDRET
ATAGAGWAAHRAAVQGGGSAQSCGLGLSPPRGPSVAP-TL-QSALVP-EECLAGDWLEDD
LPLTHSRRGSRPPHP-QSSEGSSRLRASGSG--GSSSPSRPQARARQSR--LPHLKGWST
PATAEGDRSS-ATEPPRSQEAPGATVSGGE-NPAAGQASGQG--L-PPIRVRVRVQDSLF
LVPVPLSQ-EAHSVAWLAEQAAQRYYQACGLLPRLSLQKEGALLAPQDPIPAVLQSNEEV
S---AEVTSWDLPPLTDRYRRACQSLEQGEHQQVLQVMEHQGSGPSFSACSLALRQAQLT
PLLRALKLHSALRELRLAGNRLGDGCVAELLAALDTLPG

PF13516 // ENSGT00760000119090_2_Domain_8 (1300, 1319)

LTLLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AA
GLPGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGLALASILQACPLLSALHLQACGFGPSFFLNHQAA
LGSAFQDAKCLQTLSLSYNFLGATALAQALRSLPAHTLLRLELSAVAASKG-NPGLLEPV
LRY---------LTEEGCTLEHLSLSANHLDDQAVRELSRCLPLCPSLVSLDLSANPKVS
RAGLEELLSALQERPQGLSFLGL-SGCAVQGPLGLGLWDQVAVQLQELQLCSRRLSAEDR
DAAHQL-LPSRLGPKACTLDQGPKLFFRRL-

------------------------------------------------------------
---TNMERELRQLSKAKAKAQRSGQLRDEAALCHQLGELLASHG--RYAEALREHQHELQ
LLESVDDPLGCAVAHRKIGERLAELEDYSAALK--HQHRYLELAHSLSNHTEVQRAWATI
GRTYLDIYDHCQSQDTLLQAQTAFEKSLAIVDEKLQGTLAKRELSEMR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

TRLYLNLGLTFE
SLRQMAPCNDYFRKSIFLAEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NHLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

FRARYNLGAIHWRRGQHSQAMRCLEGARECAR
VLRKELMESECCMLISQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGIQKPLQKAAVCRALKYV-LAVVRLQQQLQESEGS-DPQGAMGICE

PF00515 // ENSGT00760000119090_2_Domain_3 (414, 434)

QLGDLFS
KAGDFPKAAEAYQ

ENSGT00760000119090_2_Linker_3_4 (434, 450)

KQLHFAELLGRPGPEL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AIIHVSLATTLGDM-KDYRRAVSHYEQELRL
RGGDALEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PVTAATLQELSVPRDQEDDD------EEEK----EGDGDTPEAS--
-DVELSESEGDAEGRSQQL-----EEDEELQG----CLGQQRVN----------------
--------------KWNRRNDVGETLLHRACIEGRLGRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 747)

CGWTPL
HEACNYGHLDIVRFLLDHGAVVDDPG

ENSGT00760000119090_2_Linker_5_6 (747, 751)

GPGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALHCGHFEVAELLIERGASVTL
RT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

MKGHSPLETLQQWVKLYGKDLDSETREKAGSMESLLRAAS---SG-Q-----APHSSL
APHILPRNHLFDPEISPPSSPCPGP-------PETSQARA------GVSPGQAVPAAARP
RRTRHNLASS-SS----SEGEDNPGPPRPVQKRPRHYVPAQQARTGVPG---ST-SSREA
VAVSATRA----AVRGVGGAQICCPGPGLRWGPGEPT-PP-RAALIPEEACLAGDWLEDD
SPLTHSHQGGYLPHP-QGSGDGTRPGGLGSG--GSKSPGRLRARARQSR--LPRLRSWNA
LSRAGGDSS--AAELPRSPDMSRASGPSGD-SPAAGQPLGPS--LPPPIRVRVRVQDSLF
LIPVPHSR-ETHSVAWLAEQAAQRYCQACGLLPRLVLRKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLTDRYRRACQSLEQEEDQEVLQAVDRQGSGPSFSACSLALHQTQLT
PLLRALKLHT

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1297)

ALRELHLAGNRLGDGCAAELLAALGTMPSLVLLDLSSNHLGPEGLRQLAT
GLQGQTALQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLQELDLSMNPLGDGCGRALAFILQA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPSLSTLHLQACGFGPSFFLSHQAA
LGSAFQDAK

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

HLQTLSLSYNILGTAALAHALQNLPAHNLQRLELSSVAASKS-DSGLVEPV
VRY---------LTKEGCVLAHLSLSANHLGDKAVGDLSRCLPCCPSLISLDLSANPEIS
CVGLEELLSALQMRPQDLSFLGL-SGCAVQGPLGLGLWREITTRVHELQLCSRRLSPEDR
AALRQL-LPGQPGPGACSLDRGPKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------ASIPGEI-KDPQGAWHHYEEELRL
RAGNAVEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQILQH
LHTVQLHLHPQEA-ASTEAKLQELSRSGEEEEEEEEE---EAEK----EGDADVLEPS--
-EVELSESEEEANGWSPQR-----DEEEP-------RGPRRKVD----------------
--------------RWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

VGETLLHRACIEGQLGRVQDLVRQGHPLNPRDHCGWTPL
HEACNYGHLEIVHFLLDHGASVDDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAELLIKRGASVTL
RT

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

KKGLSPLETLQQWVQLYRKDLDYDTQAKARAMERLLRATS---SD-PGKQGSACPSSL
NAQTFPSNHLFDSETSPPSSPCPSP--------GASQACA------RASWEQVAGAPPRP
RRSWQELVGS-SS----SEGEDNTDPPRPAQKRHRT--SAQQAKAQKPS---PT-GNREL
AVVGAGRAAYVAAIRGVGSAQNCQLGSSPLWSPGEAP-TP-PAALIPEEEFLTGDWLEED
SLLTHSHWSSHPARP-QDSRERNRHSDSGSC--STKNPARSQARAKQSR--LTHFQIRRS
RAIANRNCSS-SKNPPGSPNVPRTLERGRE-EPAAAQPMGLLPPPPPPIRVRVRFQDNLF
LIPVPHSS-EARSVGWLAEQAAQRYYQACGLLPHLSLRKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWNLPPLAERYRRACQSXXXXTHQQVLQAMERQGSGPSFSTCSLALRQAQLT
PLLRALKMHT

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1294)

ALRELRLAGNRLGDTCVLELLAT

ENSGT00760000119090_2_Linker_7_8 (1294, 1299)

LCTMP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1322)

SLVLLDLSSNHLGPEGLHQLAE
G

ENSGT00760000119090_2_Linker_8_9 (1322, 1330)

LLGQTSSK

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLEELDLSMNPLGDGCGLGLASILRA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPSLSTLHLQACGFGPSFFLSHQAA
LDSAFQDAK

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1421)

HLKTLSLSYNALGTATLARALRSLPSSTLLHLELSSVSTGSD--SG--VEV
VRY------------EGCALTHLSLSADNLDNEAITELSRCLSVCPSLVSLDLSANPEID
RTGLEQLLSALQGRPHGLCFLDL-SGCAVQGPLGPGLWDQIAFRLQELHLCSRHLSAQDS
DELRRL-LP---DPGTSALDRAPKLFFRRL-

---------------------------------------------------MS-LDR---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSTGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AP-QAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGSGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPAHTLLHLELSSVAAGKG-DSGLMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSALQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLGAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

--------MPRAGRPYFPECPAPAAAVEGRGLRVGGEGRGRGAAAQRGKSGSR-GDPSM-
----NLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHQYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGKHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGR-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PETETRLRELSVAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGLTPQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAVEMLLQAAA---SG-Q-----DPHSSQ
A-FHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHV------RVSPGQAAPAMARP
RRSRHGPASSSSS----SEGEDSAGPARPSQKRPRCSATAQRVAAWTPG---PA-SNREA
ATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGHSKAL-AP-QAALIPEEECLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSST-SG--SDSEESRPRARAKQVR--LTCMQSCSA
PVNAG-PGSL-ASEPPGSPSTPRVSEPSGD-SSAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLRACPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKG-DADLMEPV
FRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-QPSRPGAGECTLDHGSKLFFRRL-

------------------------------------------------------------
---SSVSRELATHTKAGGFKRGPGLLNNNYNCCHQLGELLASHG--RYAEALEEHRQELQ
LLESADDRLGCAVAHRKIGERLAEMEDYSAALQ--HQHQYLELAHSLSNHTELQRAWATI
GRTHLDIYDHCQLRDALLQAQAAFEKSLAIVDEKLEGTLAQRELNEMRTRLYLNLGLTFE
SLQQTALCHDYFKKSIFLAEQNHLYEDLFRARYNLGTIHWRGGQHSQAMRCLEGARECAH
AMRQRFLESECCVAISQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQSLKYV-LAVVQLQQQLEEAEDS-DPQGAMATCEQLGDLFS
KAGDFPKAASAYQQQLHLAELLNRPGAELAVIHVSLATTLGDL-KDYRQAVHHYEEELRL
RGGNPLEESKTWLNIALSREEAGDAYELLAPCFQEALSC-AHQAKQPQLQ----RQILQH
LHTVQLRLQPQEA-AGTETRLQELSVAEDEEEEREEE------E----AADSEALEAS--
-EVELSESEEDTEDPSQPL-----EEEEELQV----RLGRQKVN----------------
--------------KWNRRNDVGETLLHRACIEGQLRRVQDLVGQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLEIVRFLLDHGATV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGQGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 783)

GITPLHDALNCGHFEVAELLIKRGASITL
RTKKGLSPLETLQQWVKLYHGDLDLETRQKARAMERLLQAAS---SG-Q-----EPLNSQ
GLRTLPCNHLFDPETSPPLSPCPELPSHTLKPPEFYQFCA------SVSPGQTAPAGVRP
RRSRHGPASS--S----SEDEDVVGAPWPSQKRPRCSAS-----------------SREA
ATVGTS----ETAIGSVGNSQSHHLGPGPLWGQREAS-AL-HMALVTE-EDLARDWLELD
VPLTRSR----QPCS-QSSRESIRPKASGSD--AEARLVRPQAWAEQAH--LPCIRSWTA
PVQAG-DSSL-ALECPGSPSFPRDLGPSGD-SPTVGQPSGSV--LPPPLRVRVQVQDNLF
LIPVPYSS-EAHTVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIRDVLQSNDEV
L---AEVTSWDLPPLADRYSRACQSLGQGEHPQVLQAVEHQGSSPTFSACSLGLYQAQLT
PLLRALKLHTTLRELRLAGNRLGDGCAAELLAAVGTMPNLALLDLSSNHLGPEGLRQLAT
GLPGQAALQNLEELDLSMNPLGDNCGQALASLLQACPLLSTLHLQACTFGSSFFLSHGAA
LGNAFQDAKHLKTLSLSYNALGSSTLARVLQSLPACTLLHLELSCVAAGKG-DSGLMEPV
IRY---------LTKEGCALTHLTLSANHLGDKAVRDLSRCLLCCPSLISLDLSGNPGIG
CASLEEVLSALQGQPRGFSFLGL-SGCAVQGPLGLALWDKVTVELRELQLCSRHLCTEDR
EILRKL-LPGPP--GVCTLDRGSKLFFRRL-

------------------------------------------------------------
---MTLERELRQLSKARAKAQRGGQLREEAALCHQLGELLASHG--RYTEALEEHRQELQ
LLESVDDSLGCAVAHRKIGERLAEMENYSAALQ--HQHHYLELARSLSNHIELQRAWATI
GRTHLDIYDHCQSRDDLLQAQAAFEKSLAIVDEQLEGTLVQGELSEMRTRLYLNLGLTFE
SLQQTALCNDYFKKSIFLAEQNHLYEDLFRARYNLGTIHWHRGQHSQAMRCLEGARECAR
TMRKRFMESDCCLVISQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQRATVCQNLKYV-LAVVQLQQQLEEAEGG-DTHGAMAICEQLGDLFS
KAGDFPKAAEAYQKQLHLAELLNRPEVERAIIHVSLATTLGDM-KDHRRAVYHYEEELRL
RNGNALEEAKTWFNIALSHEEAGDAYELLAPCFQKALSC-AQQAQQPRLQ----RRVLEH
LYTVQLKLQPQEA-ASTKTKLQELSVTESEEDDEEEEEETGVVE----TAASEALGAS--
-EMELSESEDDTDGLSQQL-----EEGEELRV----HRGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGATVDDPGGQGCEGITPLHDALTCGHFEVAELLIERGASVTL
RTRKGHSPLETLQQWVKLYHRDLDFETQQKARAMERLLQAAS---SG-Q-----APHNSQ
ASQPIPSNHLFDSETSPPSSPCPEPSSHTLRHPEASQARV------RVSAGQAVPAVARP
GRRRHRPASNSGS----SEGEDSVGASWPSQKRPRSSALAPQAETR------KA-SKREA
ATASTSWVAYQAAIRGVGSAQSRHLGPGLPRGQSEAL-TR-QAALIPEEEYLTGDWLEFE
TPLIHSHQGSFQPHP-QDTGDSSRPSASGSD--SEEHPIRPRTRAKQIH--LTSLESWSA
PVKAG-DSSL-AAEPPGS---PRTLGPTGD-NPTVGQPSGSV--LPPPIRVRVQVQDNLF
LIPVPQSS-EAHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLIARSRGACHSLGQGEHQQVLQVMERQGLGPSFSACSLALCQAQLI
PLLRALKLHTALRELRLSGNRLGDGCAAELLAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLHQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AT
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLHACPLLSTLRLQACGFGPSFFLSHQTA
LGSAFQDAACLKTLSLSYNALGAPTLARALQNLPARTLLRLELGSVAVSKS-DVGLLEPV
VRY---------LTKEGCALTHLTLSANHLGDKAVRDLSRCLLLCHSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCTVQGPLGLSLWNKITEQLQELHLCSRRLCADDR
NVLRQL-LPSQPGRGECTLDQGSKLFFRRF-

------------------------------------------------------------
-APPARELRRCQLSKAKAKAQRAGQLREEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHQYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGR-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVHHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PETETRLRELSVAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGLTPQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAVEMLLQAAA---SG-Q-----DPHSSQ
A-FHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHV------RVSPGQAAPAMARP
RRSRHGPASSSSS----SEGEDSAGPARPSQKRPRCSATAQRVAAWTPG---PA-SNREA
ATASTSRAAYQAAIRAVGSAWSR-LGPGPPRGHSKAL-AP-QAALTPEEECLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSRT-SG--SDSEESRPRARAKQVR--LTCMQSCSA
PVNAG-PGSL-ASEPPGSPSTPRVSEPSGD-SSAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
SRGSPQVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLRACPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGILLHLELSSVAAGKG-DADLMEPV
FRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-QPSRPGAGECTLDHGSKLFFRRL-

---------------------------------------------------MS-LER---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGERRYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLHNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVD-ELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTKTRLQELSVDEDEDEEEE-EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
ASLTLPSSLLFDPETSPPLSPYPEPPSNSTRPPEASQAHA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLATAQQVAARTPG---PA-SNNEA
AAASTSRAAYQAAIRGVGSAQSR-LGPRPPRGQSKAL-AP-QAALIPEEECQAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-ASEAPGSPSTARISEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDMPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALRPAP--
----------AATAWGLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPNFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPV
VQY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLDLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

MIL---------------------------------------------------------
------DRELRQLSKAKARAQRSGQPREEAAFCHQLGELLAGHG--RYAEALEEHRQELR
LLEGAQDPLGCAVAHRKIGERLAEMQDYSAALQ--HQHRYLELAGSLSNHTERQRAWATI
GRTHLDIYDHCQSREALLQAQAAFEKSLAIVDEKLEGTLTQRELSEMRTRLYLNLGLTFE
SLQQMALCNAYFKKSIFLAEHNHLYEDLYRARYNLGAIHWRAGQHSQAMRCLEGARECAR
AMKKRFMESECCVVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYKLGSQKPAQRAAVCQSLKYV-LAVVQLQQQLEEAEGS-DPQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 441)

EQLGDLFS
KAGDFPKAAEAYQKQLHFAERLNRPDLELAIIHVSLATTLGDM-KDHRQAVHHYEEELRL
RKGNALEEAKTWLNIALSREEAGDAYELLALCFQKALNC-AQQVQRPQLE----RQVLQH
LYTVQLRLQPQDA-PGTETKLQELSMAKEEEEEEEEEEE---VE----EGTIEALETI--
-ELELSESEDDADDPSREA-----EEDEERQG----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGASVDDPGGQGCEGITPLHDALTCGHFEVAELLIERGASVTL
QTRKGHSPLETLQQWVKLYCKDLDLETRQKAAAMERRLQAAS---LG-S-----ASHNTP
APRTVLSNHLFDPEISPPLSPCSEPLA-FPAHARISPA------------QTA-SAVARP
RRSRHRLASSSSS-----EDKDSVSPHGPSQKRLRRSALAQQDEAWTSG---PA-SSREA
ATASTSRAAYQAAIRGVGSAQSRCQGPGPFRDTSEGP-MP-QAALIPEEECLAGDWLELD
EPLIYSRPS-RLA---CPQGSGDSGSS--ASGSDEERPIRPGVRTKQSR--LTCFKRLSP
L-NKVG--SV-AAEPSGNPVMPTASGPSGE-NPEASQSMNLV--PPAPLRVRVRVQDHLF
LIPVPHSS-EAHSVAWLAEQAAQRYYQTFGLLPKLTLQKEGALLAPQDPIPDVLQSNDEV
L---AEVISWDLPPLTDRYHRACQSLGQGEHVQVLRAMERQGSGPSFSTCSLALRQAQLT
PLLRALKMHTGLRELRLAGNRLGDGCATELLAALATM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1319)

PSLVLLDLSSNHLSPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AG
GPTGQGTL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGSGQALASILRACPLLSTLRLQACGFGSNFFLSHQAA
LGSAFQDAERLKTLSLSYNPLGTPALARTLQSLPTCTLLHLELNSVAAGKS-DLGLMEPV
VRY---------LTKEGCALAHLTLSSNYLSDKAVRELSRCLPLCPSLISLDLSANPKIS
CTSLEELLSALQERSQGLSFLGM-SGCAIQGPLAPGLWDKIITQLQELRLCSRRLCPEDR
DALQQL-L---PAQGPCLLDRGPKLFFQRL-

------------------------------------------------------------
---MSLERELRQLSKDKAKAQSGGQLLEEAACCHQLGELLASHG--RYAEALEEHRQELQ
LLESAGDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHQYLELARSLSNHTELQRAWATI
GRTHLDIYDHCQLRDALLQAQAAFEKSLAIVDEKLEGTLAQRELNEMRTRLYLNLGLTFE
SLQQTALCNDYLRKSIFLAEQNHLYEDLFRARYNLGTIHWRGGQHSQAMRCLEGARECAR
SMRKRFLESECCVVISQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPLQRVAVCQSLKYV-LAVVRLQQQLEEAEGS-DPQSTVAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPKAAEAYQQQLHLAKLLNRPEAELAVIHVSLATTLGDM-KDHRQAVHHYEEELRL
RNGNALEEAKTWFNIALSREEAGDAYELLAPCFQKALSC-AQKAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLRELSVAEDEEEEEEEE------E----TVASEALEAS--
-EVELSESENDTEGLSQLP-----EEDEELQV----HRGRRKVN----------------
--------------KWNRRNDVGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRCVQDLVAQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDSLNCGHFEVAELLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTKKGHSPLETLQQWVKLYRRDLDLETRQKASAMERLLQAAS---SG-R-----EPHSSQ
GPRMIPHNHLFDPETSPPLTPCPEPPSHTPKPPEASQARV------RVSPGQAIPAVARP
RKNRRGPSSNS-S----SEDEDSMGHPQPSLKRARCSALAQQAEAWMPG---SA-SSREA
AVVGTSQAAYQAAIRGVGSAQSRHLGPGPPWGQKEVP-TP-QTALIPEEEYLAGDWLELD
VPLTHSYQGSRRPRP-QGCGESSRSRASGSD--VEERPIRPRAWAKQTR--LTCLESRSA
PVQAG-DSSS-AEECPGSSTVPRDMGPGGD-SPAVGQPSGSV--LPPPIRVRVQVQDNLF
LIPVPHSS-EAHSVAWLAEQAAQRYCQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLADRYCRACQSLGQGEHPQVLQAVERQDSGPTFSACSLALRQAQLT
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1284)

HTTLRELRLAGNRLG

ENSGT00760000119090_2_Linker_7_8 (1284, 1298)

DGCAAELLAALGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1319)

PSLVILDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDSCGQALASLLLACPLLSTLRLQACTFGPSFFLSHQAA
LSSAFQDAKHLKTLSLSYNALGAPALARALQSLPACALLHLELSSVAAGKS-DSGLMEPV
VRY---------LTKEGCALAHLTLSANHLGDKAVRDLSRCLPHCPSLLSLDLSANPEIS
CASLEELLFTLQKRLRGLNFLGL-SGCALQGPLGLELWDKTTVQLQELQLCSRRLCAKDR
DTLRQL-LPSQPGPGVCMLDRGSKLFFRRL-

------------------------------------------------------------
---MTLEQELRQLNKAKARAQRSGQLREEAACCHQLGELLAGHG--HFAEALKEHQQELH
LLESAQDTLGCAVAHRKIGERLAEMEDYSAALQ--HQHCYLELAGSLSNHTELQRAWATI
GRTHLDVYDHCQSRDALLQAQSAFEKSLAIVDEKLEGKLTQRELSEMRTRLYLNLGLTFE
SLQQTALCNEYFKKSIFLAEQNHLYEDLFRARYNLGTIHWRGGQHSQAMRCLEGARECAH
AMKMRFMESECCMVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPMQKVAVCQSLKYV-LAVIQLQQRLEEAEGN-DPHDAMAICEQLGDLFS
KAGDFPKAAEAYQKQLHFAELLNRPDLELAVIHVSLATTLGDM-KDHHQAVYHYEEELRL
RKGNALEEAKTWFNIALSREDAGDTYELLAPCFQKAFSC-AQQAQQLQLQ----RQILQH
LHTVQLRLQPQEA-PGTKTRLQELSMAKDKEEEEEEEKE---EE----ESASEALEAS--
-DLELSESEDDADSLSKRL-----QEDEELQG----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGHLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGATVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASITL
RTKKGHSPLETLQQWVKLYFRDLDLETRQKAASMEKRLQVTS---SD-P-----APHSFP
AFQTIPSNHLFDPETSPPSSPCPESSC-TLRPSKASPAPS------KVSPEAV-LPVARP
RKNRHRPASSSS----SSEGEDSMGPCRPSEKRLRWSATAQLEDARKPS---LA-SSRET
AIASAGQAAYRAAIRGVGSAQSRRLAPSVPRGSDQVP-AP-KAALIPEEEYLAGEWLELD
APVTRSSRP-T--------T---------SGSDYERCPVRTRARDRQNR--PTCLEHWRV
L-DKTGDGSL-AAEPPANSSMLRASEPSRE-NPVVGQPSLLV--QAPPIRVRVRVQDNLF
LIPVPYSD--SCSVAWLAEQAAQRYYQTCGLLPKLTLKKEGALLAPQDPILDVLQSDDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAMERQSSGPSFNACSLALHQAQLI
PLLRALKLHTVLRELRLAGNRLGDRCSAELLAALGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVG
DSLGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQAL

ENSGT00760000119090_2_Linker_9_10 (1350, 1390)

AFLLRSCPMLSTLRLQACGLGPSFLLSHQAA
LGSALQDAE

PF13516 // ENSGT00760000119090_2_Domain_10 (1390, 1404)

HLKTLSLSYNALGTPALARILQSLPVHVLLHLELGSVAASKS-DLNLIEPI
VRY---------LTKEGCVLAHLTLSANHLSDKAVRELSRCLPCCPSLVSLDLSANPEVS
DASLEALLSALQERPKGLSFLGL-SGCSIEGPLSPGLWDKIFMQLRELQLCSRHLCPEDR
DALCQR-L---PGSGTCTLDRGPKLFFQNL-

MIL---------------------------------------------------------
------DRELRQLNKAKARAQRSGQPREEAAFCHQLGELLAGHG--RYAEALEEHRQELR
LLEDAQDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHRYLELAGSLSNHTELQRAWATI
GRTHLDIHDHCQSREALLQAQAAFEKSLAIVDEKLEGTLTQRELSEMRTRLYLNLGLTFE
SLQQMALCNAYFKKSIFLAEHNHLYEDLYRARYNLGTIHWRAGQHSQAMRCLEGARECAR
AMKKRFMESECCVVVSQVPFSIYSKCISALGMGLRECIGSSSFAPQILQDLGDFLAAKRA
LKKAYRLGSQKPAQRAAVCQSLKYV-LAVVQLQQQLEEAESS-DRQDAMAICEQLGDLFS
KAGDFPKAAEAYQKQLYFAEQLNRPDPELAIIHVSLATTLGDM-KDHRQAVYHYEEELRL
CKGNALEEAKTWLNIALSQEEAGDAYELLAPCFQKALSC-AQQAQQPQLQ----RQVLQH
LHTVQLRLQPQDA-PGTESKLQELSVANEEEEE-----E---VE----EEATEAVEII--
-ELELSESEDDSDDPSREP-----EEHEERQA----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGASVDDPGGQGCEGITPLHDALTCGHFEVAELLIERGASVTL
QTKKGHSPLETLQNWVKLYCKDLDLETRQKAAAMERRLQAAS---LG-P-----ASSSTP
GPRTVLSNHLFDPEISPPLSPCFKPLA-SPAHTRISLK------------QTA-SAVARP
RRSRHRLASSSSSNSSSSDSENTVSPHGPSQKRLRRSAMAQQDEAWTSG---SA-SSKEA
ATASTSLAAYQAAIRSVGGVQSRCQGPGSFRDTSEGP-VP-QAALIPEEEYVARDWLELD
EPLMYSRPS-HLA---CPQDSGDSGSS--ASGSD-EHPVRPGARARQSR--LTCLKSWNP
L-DKVG--GM-AAEPSGNPIMPRALGPSGE-NSEAGQSMSLV--PPPPIRVRVRVQDHLF
LIPVPHSN-EAHSVAWLVEQAAQRYYQTFGLLPRLTLQKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYHRACQSLGQGEHVQVLRTIERQGSGPSFSICSLALCQTQLV
PLLRALKMHTGLRELRLAGNRLGDGCATELLSALATIP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLVLLDLSSNHLSQEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AG
GPTGQGTL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGSGQALASILRACPLLRILRLQACGFGPNFFLNHQAV
LGSAFQDAEHLKTLSLSYNPLGTPALARTLQNLPTCV-LHLELSSVAAGKS-DLGLMEPI
IRY---------LTKEGCALAHLTLSSNYLSDKAVGELSRCLPFCPSLISLDLSANPKIS
CTSLKELLSALQERCKGLSFLGL-SGCAIQGPLGPGLWDKITAQLQELRLCSRSLCPEDR
DALHQL-L---PALGVCSLDQGSKLFFQRP-

MILERELR------------------------REFLRVRLRVPWVAV---------GSGP
RFSPQLSFLRAELNKAKARAKRSGQPREEAAFCHQLGELLAGHG--RYAEALEEHREELR
LLEGTQDPLGCAVAHRKIGERLAEMEDYSAALR--HQHCHLELAGSLSNHTEMQRAWATI
GRTHLDIYDHCQSREALVQAQAAFEKSLAIVDEKLEGTLTQRELSEMRTRLYLNLGLTFE
SLQQTALCNAYFKKSIFLSEHNHLYEDLYRARYNLGTIHWRAGQHSQAMRCLEGARECAR
AMKKRFMESECCVVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYKLGSQKPAQRAAVCQSLKYV-LAVVQLQQRLEEAEGS-DLQGAMAFC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 441)

EQLGDLFS
KAGDFPKAAEAYQRQLHFAERLNRPDSELAIIHVSLATTLGDM-KDYRQAVHHYEEELRL
CKGNSLEEAKTWLNIALSRDEAGDAYELLAPCFQTALNC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQDA-PGTETKLEELSVGKEEEEE--EEEE---VE----EEAIEALETI--
-EPELSESEDDGDDPSREP-----EEDEERQG----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGASVDDPGGQGCEGITPLHDALNCGHFEVAELLIDQGASVTL
QTKKGHSPLETLQQWVKLYYKDLDLETQQKAAAMERRLKAAS---SG-P-----APHSTP
APRTVLSNHLFDPETSPPLNPCPEPLA-SAAHARISPK------------RTA-SAVARP
RRSRHRLASSSSS----SEGEDSVSPHGPSQKRLKCSALAQQDEAWTSG---PA-STREA
---STSRAAYQAAIRGVGSAQSRCRGPGLLWGTSEGP-VP-QAALIPEEEYLAGNWLEMD
EPLMHSRPS-HIA---CPQGSGDSGSS--PSESDKEHPIRPRAQAKQTR--LTCLKSWST
L-DKVG--GM-AAEPPGDPIMPKTSGASRE-SPDGGQSTSLV--QAPPIRVRVRVQDHLF
LIPVPHSS-EAHSVAWLAEQAAQRYYQTCGLLPRLTLQKEGALLAPQDPILDVLQSNDEV
L---AEVTSWDLPPVTDRYRRACQSLGQGEHLQVLQAMEHQGSGPSFSTCSLALHQAHLT
PLLRALKMHTGLRELRLAGNRLGDGCATELLAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

CLVLLDLSSNHLGQEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AG
GPTGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDSCGQALASILRACPFLSTLRLQACGFGPNFFLSHQAT
LGPAFQDAECLKTLSLSYNPLGTSALARTLQSLPTGTLLRLELSSVAAGKS-DLGLIEPL
VRY---------LTKEGCVLTHLTLSSNYLSDKTVGELSRCLPLCPSLISLDLSANPKIS
RTSLEELLSALQERSQGLSFLGL-SGCAIQGPLGPGLWDKITTQLQELRLCSRHLCPEDR
DALRQL-L---RGQGACLLDRGPKLFFQRL-

------------------------------------------------------------
---MNLERELRQLSKAKAKAQRSGQLREEASVCHQLGELLASHG--CYAEALREHQQELQ
LLETADDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHRYLELACALSNHVEQQRAWATI
GRTHLDIYDHHQSQDALQQAQDAFEKSLAILDEKLQGSLPKRELSEMRTRVYLNLGLTCE
SLQQVALCSAYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECAR
VLKQGFLES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCLLLSQ-----------------------------VLLDLGDFLAAKRA
LKKAYRLGSQKPLQKASVCRTLKYV-LAVVQLQQRLEESEES-DPEVAMGICEQLGDLFS
KAGDFPKAAAAYQKQLHFAELLNRPGPELAVIHVSLAATLGDM-KDHRQAVHHYEAELRL
QEGNPLEEAKTWLNIALSREEAGDTYEVLALCFQKALGC-AQLAGQPQLQ----RQILRH
LHAVQLRLQPEEA-PGTETRLQELQAAGDED-ERDGEDE----------EDDDALEAT--
-ELELSESEDEANA-SPPL-----EEDEELRG----CLGRQRVN----------------
--------------KWSRRNDVGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLGRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDRGAPVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGHSPLETLQQWVKLYGKDLDSETQEKAAAMGRLLQAAS---LG-Q-----APHSSQ
APQTLPSNHLFDPETSPPSSPCPGT-------PEVCEAST------RVSQGLAVSPVARP
RRSRHKVASS-SS----SEGEDNAGPSHPTQKRPRHAGPTLQTKAPMPR---PA-SDREA
ATTSASWAAYRVAMHGVGSAQTCCLGPSPLRGPSETP-IP-QAALIPKEECLAGDWLEED
FPMSSSHRGRRPARP-QSDGDGGRHCASGPGSDTARRPWA---QARQSR--LPYLESRST
PARADRADSP-ATELTRSPDVPRAVAPAGE-NPTVGQLPGQV--LPPPIRVRVRVQDNLF
LIPVPH-R-EAHSVAWLAEQAAQRHYQASGLLPRLSLQKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLKDRYRRACQALEQEEHQQVLQAMEHQGSAPTFSACSLALCQAQLT
PLLRALKLHSALRELRLAGNRLGDGCVAELLATLDTVPG

PF13516 // ENSGT00760000119090_2_Domain_8 (1300, 1319)

LTLLDLSSNHLGPDGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AA
GLLGQTTL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASVLRACPVLCTLHLQACGFGPSFFLSHQAT
LGSAFQDTKCLKTLSLSYNGLGPTALGQVLGSLPAHSLLRLELGSVATSKS-DLGLMEPV
VRY---------LSQEGCVLEHLSMSANHLGDKDVRALSRCLPLCPSLVSLDLSANPEVS
SAGLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLDLWDKVVAQLQELQLCTRRLSAEDR
DALHQL-LPSQLSPRVCTLDQGPKLFFRHL-

---------------------------------------------------MS-------
-----LERELRQLSKAKAKVQRAGRLREEAALCHQLGELLAGXX--RYAEALEQHWQELQ
LRESVGDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHRYLELARSLGNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLSEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAR
TMKKKFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLHLAELLDRPGAERAVIHVSLATTLGDM-KDHRGAVRHYEEELRL
RSGNVLEEAKTWLNIAMSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRMQPQEA-PGTEIRLQELIVAEDEEEEEEEEEA--AAT----AADSGALEAS--
-EVELSESEDDTDGLTQQL-----EEDEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLQRGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSRTIPSSLLFDPETSPPLSPCPEPPSNTTRPPEASQGRA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSTGPPRPSQKRPRCSVTAQQVAAQTPV---PG-SNREA
AAASASRAAYRAAIRGVGSAQSR-LGPGPLRGQSKAL-AP-QAALIPEEECLTVDWLELD
TAPTRSR----RPRP-QSNGDSRRPSST-SG--SDSEECRPRAVAKQVR--LTCLQSCSA
SVKAG-ASSM-ASEPPGSPSTPRASESSVD-SSAAGQLVGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAGQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQLLQAIELQGLGPSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELLGALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQLAM
GLPDQATLQGLEELDLSMNPLGDGCGHALASLLRACPALSTLRLQACGFGPSFFLSHQIA
LGSAFQDAERLKTLSLSYNALGVPALGRTLQSLPARTLLHLELSAVAASKG-GSGLMEPI
VQY---------LAKEGCALAHLTLSANHLGDEAVSELCRCLSLCPSLISLDLSANPEIS
CASLEELLSALQKRPQGLSFLSL-SGCAVRGPLGLGLWNKIAGQLRELQLCSRRLCADDR
DALGQL-RPGRPGPGECTLNHGSKLFFRRL-

------------------------------------------------------------
-----------ELEKAKCKAQRSHNLKEEASVCNQLGELLARNG--CFREAIEEHRQERM
ICEGLSDVIGCAVANRKIGECFAELGNFEAALK--HQKLHLDLARSVSSDIEEQRALATI
GRTYLYMCDAGRAEEAKGPAEEAFLKSLAIVDERLEGKVCVRELNEMR

PF00515 // ENSGT00760000119090_2_Domain_0 (229, 262)

ARLYLNLGLLYD
QLRRTDKCSFYIRKSVFISEQ

ENSGT00760000119090_2_Linker_0_1 (262, 269)

NQLYEDL

PF00515 // ENSGT00760000119090_2_Domain_1 (269, 302)

YRANFTLAGIHMRNKEHSKAIRCWEAARECAR
RMRDKHMESECYSSIGQ-----------------------------ALLTLGDLSAGKRS
LKKSFLLGSRDLTDRDIVRRNLKYA-IRGCRLEESLSELSEE-DQQGALCLYEQLGDLYC
KVGCYTRAIEDYRMQLNCAETLGRPEREL

PF00515 // ENSGT00760000119090_2_Domain_4 (450, 484)

AVIHVSLATTFTDL-KDHVQAVKHYRAELEL
RKGNPSEECKTWMNIAQSYEEDGRRHTDIQSCLSNALQC-AQRAGEAALQ----RKVLRQ
LLAVQEKLGDPEV-GDTEAKLQELCSGPGGESSEEEEE----------MENSEPLQES--
-DLELSQS----------------EDDEDLEGYEKLVPGKRRVN----------------
--------------RWNRRNEKGETVLHRACIEGNAKLVKTLIEKGHPLSPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 747)

CGWTPL
HEAANHGHLEIVELLLEKGANINDPG

ENSGT00760000119090_2_Linker_5_6 (747, 751)

GPLC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALSSGNFHVAQLLIRRGASVTL
KN

ENSGT00760000119090_2_Linker_6_7 (783, 1271)

AKGVAPLGSLQDWIGTYGKHLDQETRQNCKETESLLREAL---AGRV------AAAPS
RPESLQDSELFDAEGSQPDSLAPSWDSRADPLEEEQDD----------FVDTSPPICASP
RAGG-------DMGFSTETFEQLLTPLKPVKKRPRYSALGREHLDETEAENPPFPPVHQI
RAPDCGMEQYQKAIRDLGSAKSRLLTQSLAQPISSTPDTLSKMALVPSEEYLDDDWLEDD
LQETPRSRKRQRTFT-QSIEEEESPVSSQ----ETE---APAQLSRNNA-FIPRVQES-A
PT--RGLGSAKDSSGLLSPVILQV-GSQGGPTRPAGVV--LNPTVPPPIRVRVRVQDNIF
LIPIPHSDSETREISWLADEAAQRYYQSCGLLPRLTLKKEGALLAPQDLVLHVLQSNEEV
L---AEVHSWDLPPLTDRYRKACQSLAVEENHLLVRALERQESSQCLTFSHLSLRPRDLG
PLLRALKLQN

PF00560 // ENSGT00760000119090_2_Domain_7 (1271, 1294)

SLRQLHLSGNLLGDTEAAELLAV

ENSGT00760000119090_2_Linker_7_8 (1294, 1299)

LSTMP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1321)

NLTHLNLSSNRLTHEGIRKLAN

ENSGT00760000119090_2_Linker_8_9 (1321, 1330)

ITQEDRPFK

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1352)

SLEHLDLSVNPLGNGLSQPLAL

ENSGT00760000119090_2_Linker_9_10 (1352, 1390)

LLRSCPVLSTLHLRGCQLSAKFLQQYRIQ
LAEAFRGAV

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

HLKTLSLSHNPLGSTGLELVLKTLAPETLTRLDIQAVTSGNK-EGLLIEPL
VRY---------LSQDGCVLSHLSLACNHLTDGPALELARCLPVCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLVSLDLSGNPGIG
ADGLECLLEGIGERSTEMADLNL-AGCSIRGPLSTSCLGAISSSLCEFRLASRCLSKMDR
DSLAQA-WH----GHPLVLNRQHKIFCKSR-

------------------------------------------------------------
---MTLEQELRQLSKAKTRAQRNGQLREEAIYCHQLGELLASHG--RFKEALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDVYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCE
SLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCMLVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPNQRVTVCQSLKYV-LAVIQLQQQLEEAESN-DLQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCC-AQQAQRFQLQ----RQILQH
LYTVQLKLQPQEA-GDTEIRLQELSMAKDTEEEEEEEEE---EE----EEASEAPETS--
-ELELSESEDDADGLSQQL-----EEDEELQG----CVGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMERRLQMAS---SG-Q-----ASRSSP
ALQAIPCNHLFDPETSPPSSPCPEPSLYTPRPPEASPAPA------KVFLEETVSAMSRP
RKTRHRPTSSSSS---SEDE-DSPSPCRPSQKRLRHTTQ--QGEVKIPD---P-PKSRET
ATSSACQAAYQAAIRGVGSAQSRRLVPSLPRGSEEVP-AP-KTALIPEEEYLAGEWLEVD
TPLTRS----G------------RPST--SVSDYERCPARPRTRVKQSR--LTSLDGWCA
R-TQAGDGSL-TAEPVENPSVPRTSGPNKE-NCAAGQPLLLV--QPPPIRVRVQIQDNLF
LIPVPQS--DVRPVAWLTEQAAQRYFQTCGLLPRLILRKDGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLKDRYRRACLSLGQGEHQQVLQAMDHQSSSPSFSACSLALCQAQLT
PLLRALKLHTALRELRLAGNRLGDACATELLATLGTT

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSPSFFLSHQAA
LGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPACTLERLELSSVAASKS-NSGIIEPV
IKY---------LTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVS
CASLEELLSALQERSQGLSFLGL-SGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKDR
DSLSQR-L---PG-GACILDQGSKLFFKCL-

------------------------------------------------------------
---MSLERELRQLSKDKAKAQSGGQLLEEAACCHQLGELLASHG--RYAEALEEHRQELQ
LLESAGDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHQYLELARSLSNHTELQRAWATI
GRTHLDIYDHCQLRDALLQAQAAFEKSLAIVDEKLEGTLAQRELNEMRTRLYLNLGLTFE
SLQQTALCNDYLRKSIFLAEQNHLYEDLFRARYNLGTIHWRGGQHSQAMRCLEGARECAR
SMRKRFLESECCVVISQ-----------------------------VLQDLGDFLAAKRV
LKKAYRLGSQKPLQRVAVCQSLKYV-LAVVRLQQQLEEAEGG-DPRSALAIY

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAADFPKAAEAYQQQLHLAKLLNRPGAELAVIHVSLATTLGDM-KDHRQAVHHYEEELRL
RNGNALEEAKTWFNIALSREEAGDAYELLVPCFQKALSC-AQQAQRPLLQ----RQVLQH
LHTVQLRLQPQEA-PDTETRLRELNVAGDEEEE-EEE------E----AVASEALEAS--
-EVELSESEDDTEGLSQLP-----EEDEELRV----HRRRQKVN----------------
--------------KWNRRNDVGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLHCVQDLVAQGHPLNPRDYCGWTPL
HEACNYGHLEIVHFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAKLLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTKKGHSPLETLQQWVKLYRRDLDLETRQKASAMERLLQAAS---LG-R-----EPHSSQ
DPWTIPRKHLFDSETSPPLSPSPEPPSHTPKPPEASQAHV------RVSLGQAAPAVARP
WRNRHRPSSNS-S----SEDEDSMGSPQPSQKRTRYYAPAQQAEAWMPG---SV-SSREA
AAVGTTQAAYQAAIRGVGSAQSRHLGPGPPWGQKESS-TP-QTALIPEEEYLAGDWLELD
MPLTHSHQGSRRPRP-QGNGESSRSRASGSD--VEECPIRPRAWTKQTR--LTCLESRST
PVQAG-DSSS-ATESPGSSSVPKDMGPGGD-SPAVGQPSGSV--LPPPIRVRVQVQDNLF
LIPVPHSS-ETHSVAWLAEQAAQRYCQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLANRYYRACQSLGQGEHPQVLQAVERQGLGPTFSACSLALRQAQLT
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1284)

HTTLRELRLAGNRLG

ENSGT00760000119090_2_Linker_7_8 (1284, 1298)

DGCAAELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1319)

PSLVLLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDSCGQALASLLLACPLLSTLRLQSCAFGPNFFLSHQAA
LSNAFQDAKHLKTLSLSYNALGAPALARALQSLPACALLHLELSSVAAGKS-DSGLVEPV
VKY---------LTKEGCALAHLTLSANHLGDKAVRDLSRCLPHCPSLISLDLSANPEIS
CASLEELLSTLQKRLQGLCFLGL-SGCALQGPLGLGLWEKTTMQVQELQLCSRSLCAEDR
NTLRQL-LPSQPGPGVCTLDRGSKLFFRCF-

----------------------------------------------------------M-
----SLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHQYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVVIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGR-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PETETRLRELSVAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSEGEDDTDGLTPQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
A-FHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHV------RVSPGQAAPAMARP
RRSRHGPASSSSS----SEGEDSAGPARPSQKRPRCSATAQRVAAWTPG---PA-SNREA
ATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGHSKAL-AP-QAALIPEEECLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSST-SG--SDSEESRPRARAKQVR--LTCMQSCSA
PVNAG-PSSL-ASEPPGSPSTPRVSEPSGD-SSAAGQPLGPA--PPPPIRVRVQVQDHLF
LIPVPHSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTA
LGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKG-DSDLMEPV
FRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-QPSRPGPGECTLDHGSKLFFRRL-

---------------------------------------------------MS-LER---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGERRYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DLQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQDA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLGTAQQVAARTPG---LA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AP-PAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVEVQGSGLSFSACSLALHQAQLT
PLLRALKLHTALRELHLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFLSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPARTSLHLEL----TGKG-DSGLMEPR
YKVGEGPRKYLEPQEEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DAVRQL-RPSRPCPGECTLDHGSKLFFRRL-

------------------------------------------------------------
---MSLERELRQLSKAKTKAQRSGQLREEASVCHQLGELLASHG--CYAEALREHQQELQ
LLETTDDPLGCAVAHRKIGERLAEMEDYSAALQ--HQHRYLELACALSNHVEQQRAWATI
GRTHLDIYDHHQSQDALQQAQDAFEKSLAILDEKLQGSLPKRELSEMRTRIYLNLGLTCE
SLQQVALCSAYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECAR
VLKQAFLESECCLLLSQ-----------------------------VLLDLGDFLAAKRA
LKKAYRLGSQKPLQKASVCRTLKYV-LAVVQLQQRLEESEES-DPEVAMGICEQLGDLFS
KAGDFPKAAAAYQKQLRFAELLSRPGPELAVIHVSLAATLGDM-KDHRQAVHHYEAELKL
QEGNPLEEAKTWLNIALSREEAGDAYEVLALCFQKALGC-AQLAGQPQLQ----RQILQH
LHAVQLRLQPQEA-PSTETRLQELKAAGDED-EGDGEDEE---D----EEDDDALEAT--
-ELELSESENEADA-SPPL-----EEDEELRG----CLGRQRVN----------------
--------------KWSRRNDVGETLLHRACIEGQLGRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLDIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 751)

DDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 782)

DGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGHNPLETLQQWVKLYGKDLDSETQEKAAAMGRLLQAAS---LG-R-----APHSSQ
APQTLPSNHLFDPETSPPSSPCPGT-------PEVCEAST------RVSQGLAVSTVARP
RRSRHKVASS-SS----SEGEDSAGPSQPTQKRPRHASPSLQTKAPMPG---PA-SDREA
ATTSTSWAAYREAIRGVGSAQTCRLGPSPLRGPSEIP-IP-QAALIPQEECLAGDWLEED
FPMSPGHRGRCPARP-QSSGDGGRHRASGPGSDTARRPRA---QARQSR--LPYLESWST
PVRADRANSQ-ATEPARSPDVPRVVAPTGE-NPTTGHLPGQV--LPPPIRVRVRVQDNLF
LIPVPH-R-EAHSVAWLAEQAAQRHYQASGLLPRLSLQKEGALLAPQDPIPDVLQSNEEV
L---AEVTSWDLPPLRDRYRRACQTLEQGEHQQVLQAVEHQGSAPTFSACSLALRQAQLT
PLLRALKLHSALRELRLAGNRLGDGCVAELLATLDTVPGLTLLDLSSNHLGPEGLRQLAA
GLLGQTTLQNLEELDLSMNPLGDGCGQALASILRACPVLCTLHLQACGFGPGFFLSHQVA
LGSAFQDTKCLKTLSLSYNGLGPTALGPVLGSLPAHSLLRLELSSVVTGKS-DVGLTDPV
VHY---------LSQEGCVLEHLSLSANHLGDKDVRALSRCLPLCPSLVSLDLSANPEVS
SAGLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLDLWDKVVAQLQELQLCTRRLSAEDR
NALHQL-LPSQLGPKVCTLDQGPKLFFRHL-

---MAKLRARTEAWPLLE-------------RGKLLVGRKLRCYVAAAAAGAAPWTRSRR
DWDMSEEREIRQLKKAKAKAQKNGQLKEEAVLCNQLGEILASHG--SYREALAEHQQELH
LLEITGDVLGCAVAHRKIGERLAELEDYTSALK--HQHRHLELAQSLSSYIEQQRAWATI
GRTYLASYDHSQSVDALLQAQTAFEKSLAIVDEKLEGILTQQELSEMRTRLYLNLGLTFD
SLKQPALCSDYIKKSIFLSEQNHLNEDLFRARYNLGTIHWRDGQHSKAMRCLEGARECAR
IMKRKFMESECCVVVAQ-----------------------------ILQDLGDFVAAKRA
LKKAYRLGSQQPKQRHTICRNLKYV-VKVVSLQQRLEEAERN-DLHEALGICEQLGDLFS
KSGDFPKAAEAYQKQLQFAKSVKIPNQELAVIHVSLAATFGDL-KNYSWAVEHYEEELRL
RRGNPLEEAKTWLNIALSKEEAGKPYEELEPCFQNALQC-SQEAKKPWLQ----RQILQH
LHAIQLKYQPLEA-PNTASKLQELNCTEGWSPSKDDISE---EEEEEELENSETLEDS--
-DIELSESENEG-------------AEEEMESYGQTGPGRRRLN----------------
--------------KWNRRNDMGETMLHRACIDGQYRRVCDLVEQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNHGHLEIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGPGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLIERRASVTA
KNSKGHTPRETLRQWVKLYGKDLDQETRQKAQAMEKLLQQAAMEKLHRTASLGQASQGSL
TPQTIQTNSLFDPETSPSSSPVRSSHFLAKSEAQHPFIGNRSLNKPLTSPEQ-GLGITRP
QSYHVG------GEASSSEGDDDKVPFQPVKKRPRLLNLGQRAEGATLC---SS-ESTES
NVASASRAVYKAAIRGVGSAQARRLFKTIAKGPSQTP-VA-QSALIPEEEYLNGDWLEDD
LESHCVRRKKSHCILDNDSDC-----TSELESDGETICSSSKPRSRQSQLT--RIVDKTV
L---GRTSGS-SNSTGENPSVSRVSDISGE-NPSAGYLPCSV--APPPIRIRVRVQDNVF
LIPVPQS--ERHPVSWLADQASQRYYQTCGLLTWLTLKKEGALLAPEDLITDVLQSNEEV
L---AEVISCDLTSLTDRYRKVCQNLREAENQLILQALEQQGSGPSFSACSLALRPAQLT
PLLRALKLHTSLRELHLVGNRLGNNTAVELLSTISTMPGLTLLDLSSNHLGPDGLHHLAN
GLPNHSTFQNLEKLNLSMNPLGDGCVRALASLLQSCPALSTLRLQACGFTSNFLQNHQHT
MDNALQGARHLKLLSLSYNTLGVPALARVLQCVPHRVLTQLELGSVMTNRN-SSGFMESM
LRY---------LTQEGCALTHLNLSGNYLNDEAVRNLSRCLPICPSLISLDLTANPKIS
CCSLEEILSALQERNSGLDFLGL-SGCSIEGPLGSCTWEKITSQLQELQLCCSKLKPTDH
QALGQQ-LAFKQGPSSVILKHHHKLFFGRH-

MNLERELRRKSLGDPFL---------------------RGRGGW---GGLGTR-PRPRTP
PRRPSPPLPPTELSKAKAKAQRAGQRREEAALCHQLGELLAGHGERRYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHQYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGKHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGR-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PETETRLRELSVAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGLTPQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAVEMLLQAAA---SG-Q-----DPHSSQ
A-FHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHV------RVSPGQAAPAMARP
RRSRHGPASSSSS----SEGEDSAGPARPSQKRPRCSATAQRVAAWTPG---PA-SNREA
ATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGHSKAL-AP-QAALIPEEECLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSST-SG--SDSEESRPRARAKQVR--LTCMQSCSA
PVNAG-PGSL-ASEPPGSPSTPRVSEPSGD-SSAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
SRGSPQVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLRACPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKG-DADLMEPV
FRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-QPSRPGAGECTLDHGSKLFFRRL-

---------------MVKPCLYK---------------NTKISWAWWWAS-VI-PATQEA
EAGESLEPERRRLHKAKAKAQRAGQRREEAALCHQLGELLAGHGERRYAEALEQHWQELQ
LRERADDPLGCAVAHRKIGERLAEMEDYPAALQ--HQHQYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTMQLRLQPQEA-PETETRLRELSVAEDEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGLTPQL-----EEDEELQG----HLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
A-FHAPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHA------RVSPGQAAPAMARP
RRSRHGPASSSSS----TEGEDSAGSARPSQKRPRCSATAQRVAAWTPG---PA-SNREA
ATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGHSKAL-AP-QAALIPEEQCLAGDWLELD
MPLTRSR----RPRP-RGTGDNRRPSST-SG--SDSEESRPRARAKQVR--LTCMQSCSA
PVNAG-PSSL-ASEPPGSPSTPRVSEPSGD-ISAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
SRGSPQVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1349)

QSLEELDLSMNPLGDGCGQSLASLLRACPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLSLSYNTLGAPALARTLQSLPAGTLLHLELSSVAAGKG-DSDLMEPV
FRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLPLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCTEDR
DALRQL-QPSRPGPGECTLDHGSKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------QNHLYEDLFRARYNLGAMHWRRGQHSQAMRCLEGARECAR
VLRKDCMESDCCLLLSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPSQKAAVRQALKYV-LAVVRLQQQQEEPEGS-DPQSAMGICEQLGDLFS
KAGDFPKAADAYRQQLHLAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXEAKTWLNIALSRDEAGDAYELLVPCFQEALDR-ARQTQRPQLQ----RQILQH
LHAVQLRLHPQEA-PCTEAELQGLSEEAEGEEEDQDAD---------LDADSNSLEAS--
-ELELSESEEECEGMSPPRRQQQDEEEEEL------RAPRQRGN----------------
--------------KWNRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

VGETLLHRACIEGRLGRVQDLVRQGHPLNPRDHCGWTPL
HEACNYGHLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-----XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXX
XXXXXXXXXX-XX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XX-XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XX-XXXXXXXXXXXX--XXXXXXXXXXXXXXXX--XXXXXXXXX
XXXXXXXXXX-XXXXXXXXX-XXXXXXXXX-XXXXXXXXXXX--XXXXXXXXXXXXXXXX
XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSNHLGPEGLRQLAD
GLRGMASSQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

SLEELDLSMNPLGDGCGPALASILRA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPALSTLHLQACGLGPHLFLRHQAA
LGSAFQDAQ

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1421)

CLKTLSLSYNALGPTALTRMLQSLPASSLLHLDLSCVLGSPH-DSGLMEPV
AVY---------LTKEGCALAHLSLSANHLDNEAVGALSRCLPKCLSLFSLDLSVNSSIS
HTGLKQLLSALQERSH

PF00560 // ENSGT00760000119090_2_Domain_13 (1517, 1541)

GLRFLGL-SGCSVQGPLGPGLWAQMTAQLQELQLCSRHLSAEDR
DTLRQL-LP--PGAGACALDCAHKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNLGLTFD
SLQQAAPCDDYFRKSIFLAEQNHLLEDLFRARYNLGAVHWRRGQHSQAMRCLEGARECAR
VLRRERMESECCVLISQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGFQTPLQKAAVCRTLKYV-LAVVRLQQRLREAEGS-DPQGAMGICEQLGDLFS
KAGDFPKAAEAYQKQLHLAELLGRPGPELAVIHVSLATTLGDM-KDHHRAVSHYEQELRL
RGGDALEEAQTWLNIALSREEAGDAYEQLAPCFQKALSC-AQQAQRPQLQ----RQILQH
LHAVQLRLRPQEA-PATAASLQELSAPRVQEEDE------EEEE----EEDEATPELS--
-DVELSESEGDAESGSQRL-----EEDEELQG----CLGPPRVN----------------
--------------KWNRRNDVGETLLHRACIEGRLGRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHVDIVRFLLDHGARV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGPGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALHCGHFEVAQLLIERGASVTL
RTAKGHSPRETLQQWVKLYSKDLDSETRAKAAAMEQLLRVAS---SG-Q-----APHRSA
APHTSPRNLLFDPELSPPLSPGLGP-------SEHSQAHA------RLSPGHTVPAVARP
RRSRPKLASS-SS----SEGEDAPGPCRPVHKRPRHRVPIQQATAGVPG---YP-SGSEA
VAASAARA----AIRGAAGAQICRPGPSLLRGPGEPT-TP-RAALIPEEECLAGDWLEDD
SPLTRSRQDGSRPHP-QGSGNSPGPRGSGSG--RSKSPDGLRARARQSR--LPRLRSWNA
PGRAGGDGSP-AAEPPRSPDLSRTSGPSGD-SPATGQPPGPS--LPPPIRVRVRVQDSLF
LIPVPHGG-ETHSVAWLTEQAAQRYCQACGLLPRLVLQKEGALLAPQDPIPDVLQSNEEV
L---AKVTSWDLPPLTDRYRRACRSLEQEEHPQVLQAMDLQGSGPSFSVGSLALRQTQLT
PLLRALKLHTALRELHLAGNRLGDGCAAELLAALGTMPSLMLLDLSSNHLGSEGLRQLAA
GLQGQTILQNLQELDLSMNPLGDGCGWALASILQGCPSLSTLHLQACGFGPSFFLSHQAA
LGSAFQDAKHLKTLSLSYNILGPDALAHALQNLPAHTLQRLELSSVAADKS-DSGLVEPV
VRY---------LAKEGCTLAHLSLSANHLDDKAVRDLSRCLPCCPSLVSLDLSANPDVS
CVGLEELLSALQMRPQGLSFLGL-SGCAVQGPLRLGLWREITARVQELELCSRRLSPDDR
AALRQL-PPGRPGPGACTLDRGSKLFFRRL-

------------------------------------------------------------
---MTLEQELRQLSKAKARAQRNGQLREEADYCHQLGELLAGHG--RFMEALEEHQQELR
LLESVQDTLGCAVAHRKIGERLAEMEDYSAALK--HQHLYLDLAGALSNHTELQRAWATI
GRTYLDVYDHDQSRDALLQAQAAFEKSLAIVDEKLEGTLTQRELSEMRTRLYLNLGLTFE
SQQQTALCNDYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAIRCLEGARECAR
AMKMRFMESECCMVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPAQRVAVCQSLKYV-LAVIQLQQQLEEAEGS-DPQRAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 439)

EQLGDLFS
KVGDFPKASEAYQRQLHFAELLNRPDLELAVIHVSLAATLGDM-KDHRKAVHHYEEELRL
RRGNALEEAKTWFNIAQSREEAGDAYELLAPCFQKAFSC-AQQAQRFQLQ----RQILQH
LHTVQLKWQPQEA-PGTEAKLQELSVANDGEEEE---EE---EE----EEASEALETS--
-ELELSESEDDADSPSQQL-----QEDEELQG----CVGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQELVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTRKGLSPLETLQQWVKLYFRDLDLETRQKAACMERRLQLAS---SG-Q-----APQGSP
AVQTIRSNHLFDPETSPPSSPCAKPSSCTPRPPEASPART------KVFVEETVAAVSRP
RRNRHRPTSSSSS---SE-DEDNMGHCRPSQKRLRHSLKAQQDETQTPD---PSSKSRDT
APSSACPAAYQAAIRGVGSAQNRRLVPSLPRGSDEVP-AS-KAALIPEEEFLAGEWLELD
TPLTRS----S------------RPST--SGSDYERCPVRHPTRAKQSR--LTCLDGWGT
W-TKAGDGSL-SAEPPESPSMPRTPGPSRE-NCTAGQPLLLV--QPPPIRVRVQVQDNLF
LIPVPHS--DIHSVAWLGEQAAQRYYQTCGLLPRLTLRKDGALLAPHDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHLQVQQAIEQQSSSASFSACSLALSQAQLM
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1284)

HTTLRELRLAGNRLG

ENSGT00760000119090_2_Linker_7_8 (1284, 1298)

DGCAPELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLSQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGHAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQAL

ENSGT00760000119090_2_Linker_9_10 (1350, 1389)

ASLLRACPVLSTLHLQACGFSASSFQSHQAA
LGSAFQDS

PF13516 // ENSGT00760000119090_2_Domain_10 (1389, 1403)

AHLKTLSLSYNTLGAPALARALQSLPAHTLLRLELSSVTASKS-SSSLVEPV
VKY---------LTKEGCALTHLTLSANSLSDEAVRDLSRCLPCCPSLVSLDLSANPEVS
CASLQELLSALQERPQGLSFLGL-SGCCIRGPLDPDIWDKIFIQLQELHLCSKHLSTRDR
DALCRR-L---PA-SACSLDHGPKLFFKCL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNLGLTYD
SMKDPAMSSYYIKKSIFISEQTHLYEDLYRARYNLGTIHWRSGEHSKAMRYLEGARECAR
TMKAKFMESECCVVIAQ-----------------------------VLQDLGDFVAAKRA
LKKAYALGSQQSRQRDSIRQSLKYV-LKVVRLQQQLEEAVGS-DPAGALAVCEHLGDLFS
RAGEFPKAAKAYEKQLQLAESLGRPPAELAVIHVSLATTFGDL-RDHGRAVRHYEAELRL
RQGSPGEEGQTWLNIGLAKEEVGESYEELAPCFQSALRC-AEQAGLAQLQ----RRVLRH
LHAVQLRRAHPEA-PTTAARLRELNRAQGRGTDSEEDGEDGDLEGSEPLGDSEPLGDS--
-ELELSESEQEDVGSQQ-------EEE------ELGAPSRRRAN----------------
--------------KWNRRNDMGETLLHRACIEGQLSRVRDLVGQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNHGHLEIVRFLLEHGACV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGPGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLVERGASVSQ
RNSKGHSPRETLQQWVKLYGKDLDRETRHKAKATEQLLLQAAAGGRGRARRVGSGAFSGH
PRST-G-----------TRGK-RRAGG---------LMAARGREQDARTPRQLGDGQK--
------------------------------------------RGDVTLT---PK-GSTV-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

------------------------------------------------------------
----PTGEQSVRMLQAKARAQKNGQLHEEAAFCHQLGELLASHG--RYAEALEEHQQELR
LLESVLDTLGCAVAHRKIGERLAEMEDYSAALQ--HQHRHLELADSLSNHTELQRAWATI
GRTHLDIYDHCQSRDDLLQAQTAFEKSLAIIDEKLEGTLSQRELSEMRTRLYLNLGLTFE
SLQQTALCNDYFKKSIFLAEQNHLYEDLFRAR

PF13176 // ENSGT00760000119090_2_Domain_1 (273, 294)

YNLGAIYCREGKHSQAMRCLE

ENSGT00760000119090_2_Linker_1_2 (294, 310)

GARECAR
AMKKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVMVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYR

ENSGT00760000119090_2_Linker_2_3 (367, 413)

LGSQKPVQRAAICQSLKYV-LAVIRLQQQLEESESS-DPQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 441)

EQLGDLFS
KAADFPKAVEAYQKQLHFAERLNRPDLELATIHVSLAATRADM-KDYHQAVYHYEEELRL
RNGNALEVMCPVPSSV--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------

---------------------------------------------------MS-LDR---
--------ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGERRYAEALEQHWQELR
LRESADDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLQELSVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTPQL-----EEDEELQG----CPGRRKGS----------------
--------------KWNRRNDMGE

PF13637 // ENSGT00760000119090_2_Domain_5 (685, 728)

TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLGEQGTGAW-RTSVDTWG----------KESVLGGHQEVWGLL----CSCST
DTTQGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSAGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AP-QAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTARVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGSGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPAHTLLHLELSSVAAGKG-DSGLMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSALQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLGAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMESECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAICQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMAICEQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM-KDHHGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQHAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PDTETRLRELGVAEGEDEEEE-AEE--AAA----TAESEALEAG--
-EVELSESEDDADGLTPQL-----EEDEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDY

PF00023 // ENSGT00760000119090_2_Domain_5 (715, 743)

CGWTPL
HEACNYGHLEIVRFLLDHGAAV

ENSGT00760000119090_2_Linker_5_6 (743, 752)

DDPGGQGCE

PF00023 // ENSGT00760000119090_2_Domain_6 (752, 782)

GITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
A-FRTPSSLLFDPETSPPLSPCPEPPSNSTRPPEASQAHA------RVSPGQAATAVARP
RRSRHGPASSSSS----SEGEDSTGPPRPSQKRPRCSATAQRVAARTPG---PP-SNREA
ATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGWSKAL-AP-QAALIPEKECLAEDWLEQD
TPLTRSR----RPRP-RGTGDNHRRSST-SG--SDSEESRPRARAKQVH--LTCVQSCSV
PVNAG-LSSL-ASEPPGSPSTARVSEPSGD-SSAAGQPLGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEV
L---AEVTSWDLP-LTDRY-RACQSLGQGEHQQVLQAVELQGLGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAM
GLPGQATLQSLEELDLSMNPLGDGCGQSLASLLRACPLLSTLRLQACGFGPSFFLSHQTA
LGSAFQDAEHLKTLSLSYNALGALALARTLQSLPAHTLLHLELSSVAAGKG-DSDLMEPV
VRY---------LAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEIS
CASLEELLSTLQKRPQGLSFLGL-SGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-QPSRSGPGECTLDHGSKLFFRRL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------MRTRLYLNLGLTFE
SLQEVALCNSYFKKSIFLAEQNHLHEDLFRARY-LGAIHWRRGQHSQAMRCLEGARECAR
ALRKGFMESECCVLISQ-----------------------------VLQDLGDFLAAKRV
LKKACRLGFQKPLQKAAVHQTLKYV-LAVVRLQQRLEESEAS-DPQGAMGICEQLGDLFS
KAGDFPKAAKAYQKQLQLAELLGRPGPELAIIHVSLAATLGDM-KDHRQAVHHYEEELRL
RDGSALEEAKTWLNIALSREEAGDTYEELAPCFQKALSC-AQQAQQPQLQ----RQILRH
LHTVQLRLQHQEA-PGTEARLQELGEGEDEG---------EDDG----GEDSDAVEAS--
-EVELSDSDDEADSQSQRL-------QDELHG----GLGRQRTG----------------
--------------KWHRRND

PF00023 // ENSGT00760000119090_2_Domain_5 (682, 714)

VGETLLHRACIEGQLGRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLDIVRFLLDHGAAVDDPGGQGC

PF00023 // ENSGT00760000119090_2_Domain_6 (751, 783)

EGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGHSPLETLQQWVKLYCQDLDSETWEKAGAMERLLQAAS---TG-R-----APHSPL
ASEALLRDHLFDPEASPSSSPCPGP-------PEACQARA------RVSQASAVPPVARP
GRSRHKLASS-SS----SEGEDSTGAPQPTRKRPRRSGPAQQAKACMAG---HT-SDREV
AAVGAGRAAYRAAIRGVGSARSCRLESGPSRGPGEAP-PP-QAALIPEEECLAGDWLEDD
LLVTPGHRGCRRPQP-QGCGHSTRHHVSESS--SDESPIRPRARQ--SR--LPRMSSS-A
VGRAAGDCRS-ATEPPQSPGVPG-----GE-RPAEGQPLGPA--LLPPIRVRVRVQDSLF
LIPVPHSK-EAHSVAWLAEQAAQRYYQACGLLPRLTLRKEGALLAPQDPVPDVLQTNEDV
L---AEVTSWDLPPLTDRYLRACQSLEQEPHQQVLQAVKHQSLGPSFSACSLALRQAQLT
PLLWALKLHSALRELRLAGNRLGDACATELLAVLGTVP

PF00560 // ENSGT00760000119090_2_Domain_8 (1299, 1325)

SLTVLDLSSNHLGPEGLRQLAT
GLQG

ENSGT00760000119090_2_Linker_8_9 (1325, 1330)

QITLQ

PF00560 // ENSGT00760000119090_2_Domain_9 (1330, 1356)

NLEELDLSMNPLGDGCSQALASILQA

ENSGT00760000119090_2_Linker_9_10 (1356, 1390)

CPALSTLHLQACGFGSTFLLSHQAA
LGSAFQDAK

PF00560 // ENSGT00760000119090_2_Domain_10 (1390, 1413)

HLKTLSLSYNVLGATALAQTLQSLPAHTLLRLELSSVVASKS-DSGLMEPI
VRY---------LTKEGCALTHLNLSANHLDSEAVGDLSRCLPLCP

PF00560 // ENSGT00760000119090_2_Domain_12 (1487, 1511)

SLVSLDLSANPEIG
SEGLEGLLSALQERPQGLRFLCL-SGCAVRGPLGLGLWDKITAELQELQLCSQRLSREDR
TALRQR-LPSQPDPGMCTLDRGAKLFFRRL-

------------------------------------------------------------
---MTLEQELRQLSKAKARAQRNGQLCEEAVCCHQLGELLASHG--RFQEALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDVYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCE
SLQQTAQCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCMLVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPNQRVAICQSLKYV-LAVVRLQQQLQEAEGN-DLQGAMAICEQLGDLFS
KADDFPKASEAYQKQLHFAELLNRPDLELAVIHESLATTLGDM-KDYHKAVHHYEEELRL
RKGNALEEAKTWFNIGLAREEAGDAYELLAPCFQKAFGC-AQQAQRYQLQ----RQILQH
LYTVQLKLQPQEA-RDTEIRLQELSMAKDTEEEEEEEEE---EE----EEASEALETS--
-EMELSESEDDADGLSQQL-----EEEEELQG----CVGRRKIN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL
RTRKGLSPLETLQQWVKLYFRDLDLETRQKAASMERRLQMAS---SG-Q-----ASHSSP
ALQTIPNNHLFDPETSPPSSPCPKPPSYTPRPPEASPAPA------KVFLEETVSAVCRP
RKNRHRPASSSSS---SEDDDDNTNPCRPSQKRLRHSTQ--QGEAKTPD---P-SKSRET
AISSACRAAYQAAIRGVGSAQSRRLVPSLPRGSNEVP-AP-KTALIPEEEFLAEEWLEVD
TPLTRSSSS-S------------RPST--SISDYERCPARPRTRAKQSR--PASLDGWCT
R-TKAADASL-TAEPTENSSMPRTTGPNKE-NCAAGQPLLLV--QPPPIRVRVQIQDNLF
LIPVPHS--DVHSVAWLAEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEV
M---AEVTSWDLPPLKDRYRRACQSLGQGEHQQVLQAMEHQSSSPSFSACSLALCQAQLT
PLLRALKLHTALRELRLSGNRLGDPCATELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGPEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1330)

LVE
GSLGQTAFQ

PF13516 // ENSGT00760000119090_2_Domain_9 (1330, 1350)

NVEELDLSMNPLGDGCAQAL

ENSGT00760000119090_2_Linker_9_10 (1350, 1390)

ASLLRTCPVLRTLRLQACGFSPSFFLSHQAA
LGSAFKDAE

PF13516 // ENSGT00760000119090_2_Domain_10 (1390, 1403)

HLKTLSLSYNTLGAPALARVLQSLPTCTLLHLELSSVAASKS-NSSLIEPV
IKY---------LTKEGCALAHLTLSANCLSDKAVRELSRCLPSCPSLTSLDLSANPEVS
CAGLEELLSALQERPQGLSFFDL-SGCSIQGPLNSDLWDKILSQLQELQLCSKDLTTKDR
DTLCQR-L---PA-GACTLNQGSKLFFKCL-

--------------------------MVSAGTRKRDAGPGAGDWGPRRGRGPG-VDG---
--------LFPQT---PPQVRPRTRDACQAVLCPR---------LGRYAEALEQHWQELR
LRESAEDPLGCAVAHRKIGERLAEMEDYPTALQ--HQHHYLELAHSLRNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAH
TMRKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCVAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYR

ENSGT00760000119090_2_Linker_2_3 (367, 413)

LGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEDAEGS-DPQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 439)

EQLGDLFS
KAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAATLGDM-KDHRGAVRHYEEELRL
RSGNMLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQAQRPQLQ----RQVLQH
LHTVQLRLQPQEA-PGTETRLQELIVDEDEDE----EEE--AAA----TAECKALEAS--
-EVELSESEDDADGLTLQL-----EEDEELQG----RPGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAA---SG-Q-----DPHSSQ
DSLTIPSSLLFDPETSPPLSPCPKPPSNSTRPPEASQARA------RVSLGQAAPAVARP
RRSRHGPASS-SS----SEGEDSTGPPRLSQKRPRCLATAQQVAARTPG---PA-SNREA
AAASNSRAAYQAAIRGVGSAQSR-LGPHPPRGQSKAL-AP-QAALIPEEECLAGDWLELD
TPLTRSR----RPRP-QGTGDSRRPSST-SG--SDSEESRPRARAKQVR--LTCVQSCSA
PVKAG-PSSL-SSEPPGSPSTTRVSEPSGD-SSAAGQPLGLA--MPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQASGLSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QSLEELDLSMNPLGDGCGQALASLLRTCPLLSTLRLQACGFGPSFFPSHQTA
LGSAFQDAEHLKTLCLSYNALGAPSLARTLQSLPARTLLHLELSSVAAGKG-DSGLMEPI
VQY---------LAKEGCALAHLTLSANHLGDKAIRDLCRCLSLCPSLISLDLSANPEIS
CVSLEELLSTLQKRPQGLSFLGL-SGCAIQGPLGLGLWDKIAAQLRELQLCSRRLCAEDR
DALRQL-RPSRPCPGECTLDHGSKLFFRRL-

------------------------------------------------------------
---MTLEQELRQLRKAKARAQRKGQLPEEAVYCHQLGELLAGHG--HFMEALEEHRQELH
LLESVQDTLGCAVAHRKIGERLAEMEDYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDVYDHHQSRDALLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTFE
SLKQTALCNDYFKKSIFLAEQNSLYEDLFRAQYNLGAVHWRGGQHSQAIRCLEGARECAR
AMKMRFMESECCVVVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPSQRVAVCQSLKYV-LAVIQLQQQLEEAEGK-DPQRAIAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 441)

EQLGDLFS
KVGDFPKASEAYQRQLHFAERLNRPDLELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEANTWFNIALSREEAGDAYELLAPCFQKAFSC-AQKAQRFQLQ----RQILQH
LHAVQLKLQPQEA-PDTETKLQELSMAKDTEEEEEE-EE---EE----EEASEALETS--
-ELELSESEDDGDSLSQKL-----EEDEELQS----CLGRRKAN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGATVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTKKGLSPLETLQQWVKLYFRDLDLETRRKAACMERRLQVAS---SG-Q-----APHGSP
AVQTIPSNHLFDPETSPPSSPCPEASSCTPRPPEASPAPA------KVFLEETVAAVSRP
RRNRHRPTSSSSS---SE-DEDNVGHCRPSQKRLRHSLKAQPDEAQTPD---PSSKSRDT
ATSSACRAAYQAAIRGVGSAQSRRLVPSLPRASDEVP-TP-KAALIPEEEFLAGEWLELD
TPLTRS----S------------RPST--SGSDYERCPVRHPTRAKQSR--LTCLDGWGT
W-TKARDGSL-ATEPPESPSMPRTSGPNRE-NCTAGQPLLLV--QPPPIRVRVQVQDNLF
LIPVPHSS-DVHSVAWLGEQAAQRYYQTCGLLPRLTLRKDGALLAPHDLIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAMEQQSSSPSFSACSLALCQAQLI
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1284)

HTTLRELRLAGNRLG

ENSGT00760000119090_2_Linker_7_8 (1284, 1298)

DGCAPELLATLGTM

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLSQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPMLSTLHLQACGFSAGFFQSHQAA
LGSAFQDVEHLKTLSLSYNTLGAPALARVLQSLPAHTLLRLELSSVAASKS-NLSLVEPV
VKY---------LTKEGCALAHLTLSANSLCDKAVRELSRCLPCCPSLVSLDLSANPEVS
CASLEELLSILQERPQGLSFLGL-SGCSIQGPLNSDIWDKIFMQLQELQLCSKRLSTRDR
DAVCRR-L---PA-SACSLDQGPKLFFKCL-

------------------------------------------------------------
---MTLEQELRQLNKAKTRAQRNGQLREEAAYCHQLGELLASHG--RFKDALEEHQQELH
LLESVQDTLGCAVAHRKIGERLAEMENYSAALK--HQHLYLDLAGSLSNHTELQRAWATI
GRTHLDIYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCE
SLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECAR
AMKMRFMESECCVLVSQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPNQRVTVCQSLKYV-LAVIQLQQQLEEAEGN-DLQGAMAIC

PF13176 // ENSGT00760000119090_2_Domain_3 (413, 440)

EQLGDLFS
KAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDM-KDHRKAVHHYEEELRL
RKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCC-AQQAQRFQLQ----RQILQH
LYTVQLKLQPQEA-RDTEIRLQELSMAKDTEEEEEEEEE---EE----EEASEALETS--
-ELELSESEDDADRLSQQL-----EEDEELQG----CVGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTL

ENSGT00760000119090_2_Linker_5_7 (781, 1269)

RTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMEKRLQMAS---SG-Q-----ASRSSP
ALQTIPSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPA------KVFLEETVSAVSRP
RKTRHRPTSSSSS---SEDE-DNPSPCRPSQKRLRHTTQ--QGEVKIPD---P-PKSRET
ATSSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVS-AP-KTALIPEEEYLAGEWLEVD
TPLTRS----G------------RPST--SVSDYERCPARPRTRVKQSR--LTSLDGWCA
R-TQAGDGSL-NAEPAENPSVPRTSGPNKE-NCAAGQPLLLV--QPPPIRVRVQIQDNLF
LIPVPQS--DIRPVAWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLKDRYRRACLSLGQGEHQQVLHAMDHQSSSPSFSACSLALCQAQLT
PLLRALKL

PF13516 // ENSGT00760000119090_2_Domain_7 (1269, 1285)

HTTLRELRLAGNRLGD

ENSGT00760000119090_2_Linker_7_8 (1285, 1298)

ACATELLATLGTT

PF13516 // ENSGT00760000119090_2_Domain_8 (1298, 1318)

PNLVLLDLSSNHLGQEGLRQ

ENSGT00760000119090_2_Linker_8_9 (1318, 1329)

LVE
GSSGQAAL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSSSFFLSHQAA
LGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPACTLKRLDLSSVAASKS-NSGIIEPV
IKY---------LTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVS
CASLEELLSALQERSQGLSFLGL-SGCSIQGPLNSDLWDKIFMQLQELQLCTKDLSTKDR
DSVCQR-L---PE-GACTLDQSSKLFFKCL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------LTQRELSEMRTRLYLNLGLTFE
SLQQMALCNAYFKKSIFLAEHNHLYEDLYRARYNLGTIHWRAGQHSQAMRCLEGARECAR
AMKKRFMESECCVVVSQ-----------------------------ILQDLGDFLAAKRA
LKKAYRLGSQKPAQRAAVCQSLKYV-LAVVQLQQQLEEAESS-DRQDAMAICEQLGDLFS
KAGDFPKAAEAYQKQLHFAEQLNRPDPELAIIHVSLATTLGDM-KDHRQAVYHYEEELRL
CKGNALEEAKTWLNIALSQEEAGDAYELLAPCFQKALSC-AQQAQQPQLQ----VQELV-
----PPTLGPQQAQ--------GFSAGL------PQAQS--WA-----------------
----GCIPEDDSDDPSREP-----EEHEERQA----CLGRRKVN----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGRLRRVQDLVKQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGASVDDPGGQGCEGITPLHDALTCGHFEVAELLIERGASVTL
QTKKGHSPLETLQNWVKLYCKDLDLETRQKAAAMERRLQAAS---LG-P-----ASSSTP
GPQTVLSNHLFDPEISPPLSPCFKPLA--------SPAHT------RISLKQTASAVARP
RRSRHRLASSSSS----NNSENTVSPHGPSQKRLRRSAMAQQDEAWTSG---SA-SSKEA
ATASTSLAAYQAAIRSVGGVQSRCQGPGSFRDTSEGP-LP-QAALIPEEEYVAGDWLELD
EPLMYSRPSH--------------------LAWSDEHPVRPGARARQSR--LTCLKSWNP
L-DKV--GGM-AAEPSGNPIMPRSVRVQGK-KNACA------------------------
-N-PLHSN-EAHSVAWLVEQAAQRYYQTFGLLPRLTLQKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYHRACQSLGQGEHVQVLRTIERQGSGPSFSICSLALCQTQLV
PLLRALKMHTGLRELRLAGNRLGDGCATELLSALATIP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLVLLDLSSNHLSQEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AG
GPTGQGTL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGSGQALASILRACPLLRILRLQACGFGPNFFLNHQAV
LGSAFQGELTRQVYSLSPGEETQRPWA----EAPGTS-------CV-SGMA-SSASLNTQ
VEC---------LGSEG---------------YVVCAQPGCLPFCPSLISLDLSANPKIS
CTSLKELLSALQERCKGLSFLGL-S-----------------------------------
-------------------------------

---------------------------------------------------MS-------
-----LERELRQLSKAKAKVQRAGHLRDEAALCHQLGELLAGHG--RYAEALEQHWQELQ
LRESVGDPLGCAVAHRKIGERLAEMEDYPAALQ--HQQRYLELARSLGNHTELQRAWATI
GRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFE
SLQQTALCNDYFRKSIFLSEQNHLYEDLFRARYNLGTVHWRAGQHSQAMRCLEGARECAR
TMKKRFMES

PF13181 // ENSGT00760000119090_2_Domain_2 (310, 367)

ECCMAIAQ-----------------------------VLQDLGDFLAAKRA
LKKAYRLGSQKPVQRAAVCQNLQHV-LAVVRLQQQLEEAEGS-DPQGAMVICEQLGDLFS
KAGDFPRAAEAYQKQLHFAELLDRPGAERAVIHVSLATTLGDM-KDHRGAVRHYEEELRL
RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC-AQQARRPQLQ----RQVLQH
LHTVQLRMQPQEA-PGTEIRLQELTVAEDEEEEEEEEAA--AAA----TVDSGALEAS--
-EVELSESEDDTEGLTQQL-----E-DEELQG----RLGRRKGS----------------
--------------KWNRRNDMGETL

PF12796 // ENSGT00760000119090_2_Domain_5 (687, 781)

LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPL
HEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL
RTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAT---SS-Q-----DPHSSQ
ASRTIPSSLLFDPETSPPLSPCPEPPSNTTRPPEASQARA------RVSPGQAAPAVARP
RRSRHGPASS-SS----SEGEDSTGPPRPSQKRPRCSATAQRVAAQTPG---PA-SNREA
AAASASRATYQAAIRGVGSAQSR-LGPGPLRGQSKAL-GP-QAALIPEEECLTGDWLELD
TPPTRSR----RPRP-QSNGDSHRPSST-SG--SDSEECRPRALAKQVR--LTCLQSCSA
SVKAG-TSSM-ASEPPGSP---RASEPSGD-SSAAGQLVGPA--LPPPIRVRVQVQDHLF
LIPVPHSS-ETHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDPIPDVLQSNDEV
L---AEVTSWDLPPLTDRYRRACQSLGQGEHQQLLQAVELQGLGPSFSACSLALHQAQLT
PLLRALKLHTALRELRLAGNRLGDKCVAELLGALGTMP

PF13516 // ENSGT00760000119090_2_Domain_8 (1299, 1319)

SLALLDLSSNHLGPEGLRQL

ENSGT00760000119090_2_Linker_8_9 (1319, 1329)

AM
GLPDQATL

PF13516 // ENSGT00760000119090_2_Domain_9 (1329, 1350)

QNLEELDLSMNPLGDGCGQALASLLRACPLLSTLRLQACGFGPSFFLSHQIA
LGSAFQDAECLKTLSLSYNALGVPALGRTLQSLPARTLLHLELSSVAASKG-DSGLMEPI
VRY---------LAKEGCALAHLTLSANHLGDKAVRELCRCLSLCPSLISLDLSANPEIS
CASLEELLSALQKRPQGLSFLSL-SGCAVQGPLGLGLWDKVAGQLRELQLCSRRLCAEDR
DALSQL-RPSRPSPGECTLNHGSKLFFRRL-