Query Results 

------------------------------------------------------------
-----------------LT-GEKWSSYCLSSLAAHNVCTSKFSNSWAQLDSSSLS-NSIG
SSASNSFLHALAVEESS

PF00989 // ENSGT00760000119045_0_Domain_0 (138, 252)

QHLPAAARNPNKAIFTVDTSTTEILVANDKACELLGYSSQELI
GQKLSRFISKCSREMWEAVGEESLETDECSSVFSGTVVDVIGRLKQKIPVSVWLRRIKSK
DNKCCVVLLEPVERLSAFVSFRVDGEITSCDLLFAHL----------------HGYPTLE
EVVGLHIKDLVPSVQIPLLGKKIPKNLRIQRAVGRSREGNTFPLSLKLQVSLLEEDQTAV
QN-------------NDYHYSATVEVLSTISGLITVQSDGTIHCIKDSFALTLFGYEKKE
LLGKNITFLIPGFYNNMERSND-CSLPLPPLDDSVGTESECFFEDVTACH-TTGSSCCNK
GK-------ES-SSFVA-------A------------SLASR------LSRDEE------
----------------------------------KKLE-RSHNIFTDSEDSIVADSPS--
-----ARCEEPSPETWPDRIRAVEQ---------------------------------CR
VVEK-------------------------AGLYNSQKICHSRVSPT--------------
SSASEQ----------------------------------LDSGQNT-KTPVRSSHSAAS
SASETGNAGES-----------GVLPSPLQ-VDHQDLKELNCQ-----------------
--QV-PRLPYAMLEDQHST-----------------------DAQGQSSSANVSSSTASY
SPEDELDTASHGVDKP----SSFACNSSKIPKINELWSGT----TPDF---------QSH
GARGQLSKTSLICDAKL---SNVDHSVIESCLLNDASSFSFANGRNSIHDVHS--GNEMS
CTASA--LG--------VATKHKGVKESDA-ELSCIRSGLEELDLNIGVKENSANCLGAT
ADP-GVSSSNALGSAVGN------------MLTQNSAFS--TGHEKQLLNGV-AV---EG
GSGWLAYLQHLENSE-GSSEVFLDKSETFVETVGDNINRNPL-KSEGNPEEDCLLDGQES
TEIKVTSTPVKQDG---RLNPAPPLNAEILEGSYTGNCCHRDGSQ-----LSILFEVKRV
ELQDPDMLFCVWVVKDLLQSQK-EAAAKTQLLLSSLASSTQSI-ADLSTHSLGEAI--RS
TSLFENSRRAEELERLRACEGEYAKK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YDTLSLIGK-GSFGFV---WTARDKKDH-QEVVV
KFIWKERVLEDCWVDDPDVGRVTQEISILLKLQHPSIIKVLDVLENEHFFQLVMEKHGSG
LDLFTFIDNQPDLDEPLASYLFRQ-------IVSAVGYLHCRNILHRDIKDENIVIAEDF
TVKLVDFGSAAYLEPGKLFYTFCGTIEYCSPEVLSGQAY-HGPELEMWSLGVTLYTLIFG
ENPFCELEEAMAAVLNPPRLVSKDLMNLIAGLLHPVPEQRMTLAVLVEDPWLKQPVNLGN
YTWEEVY-----------------------------------------------------
--------------------------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKHLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 394)

PLSLKLKS--QPNSEEA-
-TP------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGEKTLDL-WQGQDPAEG
AQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQVLPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLERMGVSGPGGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPALS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSRCSCAT
SELRGTPSSLAVGSDPDVAS----------LQEQGSRVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLVSSEHYVASDGESPGHIPSVLD-AGPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHL-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCFHPGDPRVLTS-----------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKHLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 394)

PLSLKLKS--QPNSEEA-
-TP------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLERMGVSGPGGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPALS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSRCSCAT
SELRGTPSSLAVGSDPDVAS----------LQEQGSRVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLVSSEHYVASDGESPGHIPSVLD-AGPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHL-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCFHPGDPRVLTS-----------------------

-----------MEDR-GP-PVLAEDWKS--ESLPAQ---EGPATQA-FVEPSKPLSIAHR
HLNRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CAATPDYADPIAGPLG
STSCCSLLRGLASGCSGPLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLTQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQD
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVIDLIPSIQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKS--KTSGKAV-
-AE------SE--VASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 437)

LITLLPDGTIYGINHSFALMLFGYGKTE
LLGKNITCLIPGFYHC

ENSGT00760000119045_0_Linker_2_3 (437, 1347)

MDLAYD-SSVQLPDLVNCLDIGSKSGPGEMSSDA-KQDWELASG
AQ---DPRIDV-------LTRGHMPSQD------E-TLKLRGG---Q-VSPRTQTQL-ET
GRH--ILPS---------C--ASQPSL--------------------GVDSSPVD-----
-------GERSLPTDQR--------------------NVPKRNLLAHAEQLLSQTQPD--
----------TLEISPPVLKE--LSEIQKNISEESPLTHRKWLL----------------
--SKAQKDTTKGSLPIHDE-------------------KLLLASQ----------HIHVL
GKENPS-AAESYR---------EGLLAESR----SKPVDAKPFA--SCEDSELLVPAKDR
SNRADMSSLQ--QEAQLELMGISSPGSPNPW---ADATMPEPHTTGQIPGG-SLTYCPQH
RSEWILQQRGQDSAPSPS---AMGCVFVGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSFGGALGI---SCVELVPAEHPPFTAPVSF-CDWGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QEA-DVSSYSWNLRELFLNDRTDRTPSHCSCTT
SELSETPSLSGVGSDLDVGI----------LHRQTSDIL--AHREMLLLSG-TYFDL-RE
GHRFQEM--GAGHDGAELSNISLVSSEHYETSDIESLGCDPPIPD-PGPNNMCLSAEKPR
LSAQITSTP--------VAPGPTSLQQEIQEGIFSGSCYHRDGLR-----LSVQFEVKRV
QLQGSATLFCCWLVKDFLHSHR-DSATRTRLFLASLPSSTHSM-PDLSGSSFGEML--RA
KPWFEESPTPAELEGLAACEGEYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTLRPLGS-GAFGFV---WTAVEKEGN-KEVVV
KFIKKEKVLEDCWVEDPKLGRVPLEISILSKVEHANIIKIVDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVRYLRSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLIGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIVDPWVTQPVNLDN
YTWEEVCRTSQP-ESGLMSAASLE--LA----SRSPSEVAQTEGLC----RPPAPKEAPG
-NHCLHLEDPSSPVS-----------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACGLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVHLPPSGQHIPKHLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 394)

PLSLKLKS--QPNSEEA-
-TP------SE--AAPARGYWASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLERMGVSGPGGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTPSSLAVGSHPDVAS----------LQEQGSRVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLVSSEHYVASDGESPGHIPSVLD-AGPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHL-DSAARTRLFLASLPSSTHSTAAELTGPNLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCFHPGDPRVLTS-----------------------

-----------MEDR-CS--VVEEDQRGPSGSTPLTVPVERPASQT-ISKSSKSLSAARR
HLSRKNGLSKLCQSRMALS-EDKWSSYCLSSLAAQNICTSKLY-CPAALEHA----GSQA
SVSCCSLLQGLSAGWSAPLLPAPVCNPNKAVFTVDAKTTEILVANDKACRLLGCSSHSLV
GQKLAQFFLKSDSAVLEALSEEHVGADGHAAVVFGTVVDIVSRSGEKVPVSVWMKRLQQE
RSLCCVVVLEPVERVSASVDFQS-------------------------------------
--------------DLPPPGQHVPKNLKIQRSVGRARDGTTFPLSLKLKS--KSSSEET-
-DA------SE--VVPQWSYSASVWVFCTISGLITLLPDGTIYGINHSFALTLFGYGKTE
LLGKNITFLIPGFYHYMDLAYD-SSLQLPDLASCPDVSNEKGSGEMPTDS-WQGWGLAGE
VQ---DPEGSV------MLTSDHVLPQD------E-TLKLAGS--RD-ILTGTQTQR-QP
GSG--GP--------------WSQPPP--------------------GVDAVSE------
------------------------------------------------------------
---------------------------------GSPPAHSVQLP----------------
--PEPQ-------------------------------------------------RVTAL
GKEEPG-ATESPK---------QGLLEESG----SEPVHTQSP--ASGEASETPVPAEDW
KSDAGVCDPR--QESWLELAGLSGPSGINSW----ASATAEHRAMGQPAGGGLLMHCPRY
GGEWGLRPKSQDLTPSPS---GVACVSFGTPTLDEPWLGMKDD-REEL---------QTC
LIKEQLSSLSFAGAPGI---TCIELVPAEHTPFPASMSS-CDVGGRDLHGSRP--GSSSA
CYALA--TD-LP----GALRAVES---QEA-DMNSFSWNLKELFFSHQTDQTSSSCSYAT
SELIGTPSPSVVGSDLDVSS----------LLGQSSGVS--DDRELLLLTG-TRFDL-GE
GQRFRES--CLGCDQAEPSEVSLVSLEHFEVSDCENPACTLHTAD-TGPKDAPCSAEEPR
LNVQVTSTP--------VTPGAATLQREIREGSYSGSCCHRDGLQ-----LSVQFEVKRV
ELQGPAPLFCCWLVKDLLQSHR-DSATRTRLLLASLPSSAHSI-SELPGPSPGELL--RA
KPWFEEAPRAVELEGVAACEGEFSCKY

PF00069 // ENSGT00760000119045_0_Domain_3 (1348, 1612)

SALSPLGS-GAFGFV---WTAVDKEEN-KQVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRSRNILHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAAIHPPYLVSAELMSLVSGLLQPAPEQRTTLEKLVIDPWVTQPVNLAD
YTWEEVCRVNKP-ESGVLSTASLE--TG----SKSLSEAA--Q-----------------
--------------------------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSRSFSSAHR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQSICTSKLH-CPAAPEHTDPF-GPRG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 242)

AIFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLMQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMQQE
HRLCCVVVLEPVERVSTWVAFQSDGTITSCDSLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPSSEEA-
-TT------GE--AAPVRGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFLIPGFYSYMDLVYD-SSLQLPDLASCLDVGDESGCGERTLDP-WQGQDPAEG
AQ---DPGINV------VLAGGHIVPRD------E-TRKLVES--QD-IFTGTQTEL-GA
GGQ--LLSR---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHSEQVLPEDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--TSCEDSEAPVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSGSDLW---AGAAVAEPQAKGQLAGGSLLMHCPCY
GSEWGLWWQRQDLAPSPS---GMAALSFGTPTLDEPWLGMKND-REEL---------QTC
LIKEQLSQLSLVGALDV---PHTELIPTERPAVTAPVSS-CDLGGRDLYGGCT--GSSSA
CYALA--TD-LP----GGLKAVEA---QEV-DVNSFSWNLKELFFSDQKDQTSSDCSCAT
SELRGTPSSLAVGSDPDVGS----------LQEEGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRDS--CLGHDPTEPLEVCLVSSEHYAASDRESPGCIPSTLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMPGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSAARTRLFLASLPSSTHSTAAELTGPNLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQKYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1607)

SPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRVNKP-ESGVLSTASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRLLTS-----------------------

-----------MEDK-GS-PAFEEEQWCLCGDLSSPAPTEGPAVQA-----SKSLSSAHR
HLNRRNGLSKLCQSRMALS-EARWSSYCLSSLAA-NICTSKLH-CPATPEQADPA-GSLG
S-TCCYLLRGLSSGCSPPLLPAPAGNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 209)

AIFTVDAKTSEILVANDNACQLLGYSSHDLI
GQKLTQFFLKPDSDVVEALSEEHLEADGHAAVVFGTVVDVVSRGAEKIPVSVWLKRVEQE
HRLCCVVVLEPVERVSAWVAFQSDGAITSCDSLFAHL----------------HGYESGE
DVVGQRITDLIPSVQLPPPGEQVPVTLKIQRAVGRAKDGATFPLSIKLKS--RPSGEEA-
-EGGP--------GAPQQGYWASVWAFSTVSGLVTLLPDGTIYGINHSFALTLFGYGKSE
LLGKNITFLIPGFYHHMDLAYD-CSLLPPDLARCLDLGSQSGPGELPGDP-QQGQGPG--
---------AN------VLAGDHTLPRD------D-TLKPLGS--QE-AVAESQAQA-DP
GGG--RPSS---------L--PSRPTP--------------------GVDSIPEGSPA--
-----AQE-RSLPEDQR-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------DPVP
EKAEPA-PTESLQ---------QDLLGGGR----SDMVDTRSF--VSCDSSETQTPTEDG
YESAEASGLS--RAAQLECTDLSSASNPDLR----------DDSAGQPTGAGLLGLHPGC
EGEHSVPQGSPASAPSPSGLRGL------QPALEEPWLGAQND-REEL---------RTC
LIKEQLSRSSFGGPLGV---SYIELVPAEHPSLSAPVSL-CDLGGQDLHAGRS--GSSAA
CYA-A--TD-VP----GALDAVGA---REA-SGNSFSW-LKELFFSEWADRTSSNCSCAS
SEHVGTASPFPAGSDVDVSA----------VHGPRSEAV--DDRELLLLAG-TYCAL-GE
GQRFREC--PLDRDRPEPSDTHLESLECDSVNGRETPGRILAMLG-AGPADTCPS-EEPR
LSIQVTSTPVRGDS--SAMPRAAGLQCEIQEGTYAGSCCHRDGSL-----LSVHFQVKRV
ELRGPTPLFCCWLVKDLLHSHL-APAPRTHLLLASLPSSSHSV-CELPGASRGQTL--RS
WPWFAEAPGAVELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVHKEEN-KEVVV
KFIKKEKVLEDCWVEDPKLGKVTLEIAILSSVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASHIFRQVS-----LVSAVGYLRSRGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEQGRLFYTFCGTIEYCAPEVLMGSPY-KGPELEMWSLGVTLYTLVFE
ENPFCELEETMEAAISPPYPVSQDLMNLMSGLLQPVPEQRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRVNKS-ESGVPSSVGQE--TE----SSTPSATALGPG---------DPR----
--------------------------------------

-----------MEDR-GS-P-------------------ESPAAQT-ATEPSESLSSAHR
HLSRRNGLSKLCQSRMGLS-EDKWNSYCLSSLAAQSICTSRLH-CLVPPEQTDLA-GSLG
SASCCSLLRGLSSGWSTPLFPTPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 242)

AVFTVDAKTTEILVANDKACQLLGHSSHDLI
GQKLTQFFLRPDSDVVKALSEEHMGADGRAAVVFGTVVDVVSRSGERIPVSVWMKKVKQE
HSLCCVVVLEPVERVSAWVAFQSDGTITSCDSPFALL----------------HGYASGE
DVLGQPITDLIPSVQLPTPGEPVPQNLKIQRSVGRAKDGTTFPLSLKLKS--QSSSETA-
-ED------GR--MVPEWSYSASIWVFSTISGLITLLPDGTIYGINHSFALMLFGYGKTE
LLGKNITFLIPGFYHGMGLACD-TSFPLPDLA------DQSGPGETSVGP-RQSRNWAGT
GVEPLDPRAPS------ASVGGHVLPGG------E-TLEPVGR-SQE-DFTGTWTQA-DP
GGH--LPSS---------L--PCLPTP--------------------GVESILEGGPP--
-----AQE-WSSPEDQR--------------------DIPEGSPPAQE-WSSPKDQRD--
----------IPEGSLPAQE-RSSPEDQRDIPEGIPPG-QEWSS----------------
--SEDQRAIPEGSPSALTQ-------------------QSSPKDQ----------PNPLL
EKEDSA-APESLR---------QDLVERSG----SDPVDTWMS--ASRE------ASEGR
SGQAKMSRPY--REAQPEWTNSSSAHHSNCW---VDSLMSKPYAAGKLAGEGLLLPCPGY
GGEQSTQSGS------PP---GTAQLPFSTPALDELWVAVEND-REEL---------QTC
LIKEQLSKLSLVGPLGV---SYTELAPADHPRCSASVSL-CDLGSRGLSS-RG--GSSSA
CYALA--TD-LP----GVLDTVQA---QEA-DGNSFSWNLKELFLDEWTDRTSSNCSCTT
MEIVGTPSPLPVGSDADLSG----------LHRRGSDVL--DDRELLLLTG-TYFHL-GE
ARQFHES--HLVPDPVEPSEMCLVSSEHYAVSGRESHTCILPTLG-AGPVDVCPA-EEPR
LSFQVTSTPVRTDS--PATSGATCVRQEIQEGTYAGSCHHRDGAQ-----LSVQFEVKRV
ELQGSSTLFCCWLVKDLLHSHW-DSATRTRLLLASLPSSSHSM-CELSGPSVGEML--RS
KPWFEEPPKAMELEGLAACEGAYSHKYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1608)

SPLGS-GAFGFV---WTAVDKEAN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVDHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDLHPNLDEPLASYIFRQ-------LVAAVGYLRSKNIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLMGNPY-KGPELEMWSLGVTLYTLIFE
ENPFCELEETMEATIHPPYLVSEDLMNLMSGLLQPVPEQRTTLEKLVTDPWVTQPVNLAN
YTWDEVCHMNKP-ESGALSGVSLE--TE----SRCAREVAWALEP---------------
--------------------------------------

-----------MEDK-GP-PVFAEDWRCLSGSPLAQ---EGLATQT-PSELSKPLSIAHR
HLSRKNGLSRLCQSRMALS-EDMWSSYCLSSLAAQNICTSKLH-CSAAPEHADSAAGLLG
STSCCSLLRGLASGCSAPLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDKACSLLEYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGRAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQE

ENSGT00760000119045_0_Linker_0_1 (241, 258)

RGLCCVVVLEPVERVSA

PF13426 // ENSGT00760000119045_0_Domain_1 (258, 317)

CVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVTDLIPSMQL

ENSGT00760000119045_0_Linker_1_2 (317, 393)

PPPGQPVPKCLKIQRSVGRARDGTTFPLSLKLKS--KPNGKAE-
-AD------SE--VTSEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 437)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHS

ENSGT00760000119045_0_Linker_2_3 (437, 1347)

MDPAYD-SSVQLPDLVNCLDIGSKSGPGEMSSDA-QQDWELASG
AQ---GPRVNV------VLACDHMLSQD------E-TLKLVGG---Q-VSLRTQMCL-ET
RCQ---------------------SAL--------------------GVDSIPVY-----
-------GENSLPTDHQ--------------------SIPKRNLLAHGGQLLSQNQQD--
----------TPEESLPVLNEHLLSEIQKNTSEESPLTHRKLLL----------------
--PKAQQDSTEGSLPIHNE-------------------QLQPTGH----------HINVL
GKETPS-AAESYR---------QGLLEESR----SKQKDTKLFA-SSCEDSEPPVPAKGK
SSSMDVCSLH--QEAQLELMGVSSPSSPNLW---ADATMPEPHTTGQLAGGGFLTHCPQY
RNEWILQQRGQDLAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSVGGTVGL--SSCVELVPAEHPPFTAPVSF-CDLGGRELHASRS--GSSSA
CYALA--TD-LP----GVLEAVET---QEM-DVNSYSWNLRELFLNNQTDRTPSHCSFTT
SELSETPSPSVVGSDLDVGV----------LKRQSSSIL--GDREMLLLTG-TYFDL-GE
GRQFQEM--GAGRGRAELSDIPLVSSEHYETSDLESPGCGPPVPD-PGSDGMCLPAEKPR
LSVQITSTP--------VAPGVPSLQPEIQEGIYSGSCYHRDGLR-----LSIQFEVKRV
QLQSSATLFCCWLVKDLLHSHR-DSATRTRLILASLPSSTHSM-PELSRSSFGEML--RA
KPWFEESPTPAELEGLAACEGEYSLK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTISPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSKVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGRLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSPELMNLLTGLLQPCPEQRTTLEKLITDPWVTQPVNLAN
YTWEEVCRTNQP-ESGLLSAASLE--LG----SKSPSEVAHTKGFD----GLPSPREAPG
DQHCLHLEDPSLPVS-----------------------

-----------MEDG-SP-PVFPKDQRCLSGSSPAQ---EGPASQA-SSEPSKPLSIAHR
HPSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CSAASEHADPAAGPLG
STSCCSLLRGLASGCSAPLHSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDVVSRSGEKIPVSVWIKRLQQE
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVTDLIPSMQLPPPGRHVPKSLKIQRSVGRARDGTTFPLSLKLKS--NPSGEAV-
-AD------SE--ATSEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 437)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHY

ENSGT00760000119045_0_Linker_2_3 (437, 1347)

MDPAYD-SSVQLPDLVNCLDIGSKTGPGEMSSDA-QQDWELVSG
AH---DPRVDV------TLAHDHVLSQD------E-PLKMMGG---Q-VSLRTQTRL-ET
ECQ--ILPS---------Y--SPQASL--------------------GVDSNPVY-----
-------GEHSLPTDHQ--------------------SIPKRNLLPRDAQLLSTNQPD--
----------TLEVSPPVLNEHLLSEIQKNTSEESPLTHRKCLL----------------
--PKAQQDTTKGSPPIHDE-------------------QLLPTDQ----------HIDVL
GKENPS-TAESYR---------QDLLEESR----SKPKDAKLLA--SCEVSEPLVPAKNR
SSSVDMCSLH--QEAQVELMGVS-PSSPKPW---ADATMPEPHTTGQLAGGGFLTHCPQY
RSEWILQQRGQDLAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSFGGALGI---SCVELVPAEHPPFTAPVSF-CDLGGRDLHVSRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QET-NVNSYSWNLRELFLNDQTDRTPSHCSCTT
SELSETPSPSVVGSDLDVGA----------LHRQSSDIL--GDREMLLLTG-TYFDL-GE
GRQFQEM--DAGHNRAELSDISLVSSEHYETSDIESPGCGPPVPDHPSTDALCLSAEKPK
LSVQITSTP--------VAPGAPTLQPNIQEGVYSGSCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLLHSHR-DSTTRTRLFLASLPSSTHSM-PELSGSGLGEML--RA
KPWFEESPTPAELEGLAACEGEYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTISPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWIDDPKLGKVTLEIAILSKVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMTLLSGLLQPSPEQRTTLEELILDPWVTQPVNLAN
YTWEEVCRTNQP-ETGLLSAASLE--LR----SRSPSEVTHTKDFN----GPPAPREAPG
DEHCLHPEDPSLSVS-----------------------

-----------------M-EAFEEDRRCLSGSLPVPAPAESPATPS-PVD-CRAPAMAHR
HLSRKNGLSKLCQSRTALS-EDRWSSYCLSSLAAQNICTSRLY-CPPTPEHADRL-GSCS
SASCCSLLRGFSAGWPTPLLPTPVSNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 246)

AVFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLTQFFLKSDSHVVEALSEEHVEADGRVAVVFGTVVDIVSRGGEKIAVSVWMKKVRQE
HSLCCVVVLEPVERVSAWVSFQSDGTITACDRLFAHL----------------HGFVSAE
EVVGQRITDLIPSVQLPPPGQQVPKNLKIQRSVGRARDGTTFPLSLKLKS--EAPSEAV-
-DE------GT--AAPARGFLASVWVFCTISGLITLQPDGSIYGINHSFALMLFGYGKAE
LLGKNITFLIPGFYQYMDLADD-SSVQLPDLAKCLDMSSDRGPGEAPLDP-WPAWDPANG
AQ---DPRVYV------ATAGSHVLPPD------E-TLSLGDS--QD-GSPETQAPL-DV
GGK--LLPS---------L--PPQPPP--------------------GEDSMPTD-----
-------R-----------------------------------LPAPAARSLSTDEQS--
----------TQESPPDAG-KQPLPENQQSIPGESPPGPGEQLL----------------
--PKDQPNIQEGSPPGPG--------------------------D----------PSPAV
GREEPA-APESPA---------EALLPESS----SEPADAKPA--AACEDSETALAAQRW
SSDV-MCGPP--REVPRDPGGLGGPGSPGSPNSLVDVTRPEPRAVGQPAEGALPAHQPRF
MSEWALHKPSQDSAPRPP---GMTSVSLGTPTQDEPWQGVKDD-REEL---------QAC
LIKEQLCPPSFAGAPDV---SYIELMPRERLAVPLPVSR-CSLRGRDMHGRA---DSSSA
RYALA--TD-LP----GVLEPVEA---PEP-GVHSYSWNLKEAFFSDQMDRTSSHCSCAV
SEPTETPCPSAGGSDSDVGG----------LSRQGSDV---DARELLLLAG-TCFRL-GE
GRRFQES------RRTEPSEVSLVSSEHFEVSDSEGPSCLLPTSD-ASSEEAQPAAEESR
PSAQVTSTP--------VTPGAASLGRQIQEGTYSGSCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKNLLHSHQ-DSATRTRLLLASLPSSTHSM-PELPGPSRGEVL--RA
KPWFEDPPKPMELEGLAACEGAYAHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDREQN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSQVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDHHPSLDEPLASYIFRQ-------LVSAVGYLRSRGILHRDIKDENIVIAEDF
SIKLIDFGSAAYLERGKLFHTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETMEAAIHPPYLVSQELMNLVSGLLQPAPQQRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRINKP-ENGVLLPASLG--------EQSLGEAG--PG-------TPAPGEASS
GQCAVGTPPR----------------------------

-----------MEDR-GP-PVFAEDWKCLSESPPVQ---EGPAAQA-TFEPSKPLSIAHK
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CAAAPEYADPTAGPLG
STSCCSLLRGLASGCSGSLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQD
RGLCCVVVLEPVERVSAWVAFQNDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGRAV-
-AD------SE--AASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 441)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHYMDLT

ENSGT00760000119045_0_Linker_2_3 (441, 1347)

YD-SSVQLPDLVNCLDIGRKSGPGEMNSDA-QHNWELASG
AQ---GPRIDV------VLAPDHMPSQD------E-TLKLVGG---Q-VSSRTQTRL-ET
GYK--ILPS---------T--ACQPSL--------------------GVDSNPED-----
-------GEQSLLTDQQ--------------------SIPKRNLPAHGGQ----NQLD--
----------TSEISLPVLKEHLLSEIQKNISEESPLTHRKWL-----------------
--SKVQQNPTKGSLPIHEE-------------------QLLFAGQ----------HIHVL
GKEDPS-AAESYR---------ERLLEESK----SKPVDAKLFA--SCEDSEPLVSVKDR
GRSVDMCNLH--QEAQLELMGVS---SPNPW---ADATMPEPHTTGQIAGG-SLTYCPQY
RSEWASQQRGQDSAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSCEGNLGI---SRVELVPAEHPPFTAPVSF-CDLGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QEA-DVNSYSWNLKELFLKDQTDRTPSHCSCTT
SELSEAPSLSVVGSDLDVGI----------LHRQTSDIL--VDREMLLLTG-TYFNL-SE
GQRFQEM--GAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPD-PGSNDMCLSAEKPR
LSAQITSTP--------VAHGATSLQQEIQEGIYSGSCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLFHSHR-DSATRTRLFLASLPSSTHSM-PELSGSSFGEVL--RA
KPWFEESPTPAELEGLAACEGKYAHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTISPLGS-GAFGFV---WTAVEKECN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSG
MDLFAFIDHHPCLDEPLASFIFRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLAS
YTWEEVCRTNQP-ESGLLSAASLE--IG----SRSPSEMAQTEGLC----GPPAPRETRG
DQHCLHLKDPSLPVS-----------------------

-----------MEDG-G-ATAFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSAHR
HLSRRNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPRA
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 240)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHVEADGHAAVVFGTVVDVVSRSGEKIPVSVWMKKMRQ

ENSGT00760000119045_0_Linker_0_1 (240, 262)

E
RRLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDSLFAHL----------------HGFVSGE
DVAGQRITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 394)

PLSLKLKS--EPSSEE--
-------------VAPSRDYWASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKGE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVSDKSGCGETISDP-WQGQDLAEG
SQ---DPRINV------VLAGGHVLPQE------E-ARKLVES--ED-IFTGTQTEL-GA
GGR--LPSY---------L--SPQPAP--------------------GVDSVAEGSPP--
-----AHGEQMLPEDQH-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ATAS
GRE-PA-AVETPG---------QGLLGGSR----PEPVDAKPS--ASCEDSEAPVPAEDG
GSDAGVWGLC--QQAQLELTGV---SGSHLW---AGVTMAQRQAKGQLAVGSLPMHCPCY
RSEQGLRRRSQDLAGSPS---GVAGISLGTPTLDEPWLGVKND-QEEL---------QTC
LIKEQLSELSLAGALDI---PHPELVPAERPAFTAPVLS-CDLGGRDLYGGRT--GSSSA
CYALA--TD-LP----RGLEEVEA---QEV-DVNSFSWNLKELFSSDQTDQTASNCSCAT
SELGGTPLSLAVGSDPDVGR----------LQEQGSCIL--DDRELLLLTG-TGVDL-GQ
GRVFRES--CLGHDPTQLSEVCSVSSERDAASDRGSPGRIPSSLD-TGPENMCPSAEEPT
LDVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPSPLFCCWLVKDVLHSHR-DSATRTCLLLASLPGSTHSTAAELTGPSLGEVL--RA
KPWFEDTPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEQN-KEVVV
KFIKKEKVLEDCWIDDPDLGKVPLEIAILSRVEHANIIKVLDVFQNHGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQVRAGQSHLVSAVGYLRLKNVIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAE
YTWEEVCRVNKP-ESGVLSTASLE--MG----SRSLSEVAQAQELC----GGPAP-----
--GCLHPRDPRLLTS-----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------LCPPEDPR
LNVRVTSTP--------VTPGAAGLQREIQEGTYSGSCYHRDGLQ-----LSIQFEVKRV
ELQGPVPLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSAHSV-SELPGSGLGEML--RA
KPWFEESPRAVEPEGLAACEGAFSCK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEEN-KQVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRSRNILHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAAIHPPYLVSAELMSLVSGLLQPAPEQRTTLEKLATDPWVTQPVNLAD
YTWEEVCRVNKP-GERLLGMPPSL--RG----F-----------AW----SKQVPRLPA-
--------------------------------------

-----------MEDG-GS-AAFEENQRSLCGSSSLPAPTESPSAQTTASEPSKSLSSARR
HLSRRNGLSKLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CPATPEQADLA-GSLG
STSCCSLLRGLPSGWSVPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 205)

AVFTVDAKTTQILVANDKACQLLGYSSHNLI
GQKLTQFFLKPDSDVVEALSEECVEADGRAAVVFGTVVDIVSCSREKIPVSVWMKRVKQE
HSLCCVVVLEPVERVSAWVAFQSDGTITSCDSVFAHL----------------HGYASGE
EVVGQRITDLVPSVQLPPPGEHVPKNLKIQRSVGRAKDGTTFPLSLKLKS--KPSSEEA-
-ED------GK--AAPKWGYSASIWVFSTISGLITLLPDGTIYGINHSFALMLFGYGKTE
LLGKNITFLIPGFYHCMDPAYD-SSLPLPDLADCLDIGSQSGPGETTVDP-RQGWNLASA
GE---DPSVDV------VLAGDHILPRD------E-TLKLVGS--QE-AFTGTQAQA-DT
GGH--LPSS---------L--PSPPAP--------------------GVDSIPEGSPP--
-----SQERQ--------------------------------------------------
-----------------------------------------QSL----------------
--P---------------------------------------EDQ----------RNAVL
EKEEAA-ATESLR---------QDRLGGSR----SDPGSTKPFAS-RRGDSETPAPTEDR
SRNVEMCGPY--QEAQLERMGSSSASNSN---IRAEAAMLEPCAVGQPAGLSVPMHCAAY
SGERRAQQGSRDSAPSPS---GMLRLSFSTPTLDEPWLGAKND-REEL---------QTC
LIKEQLSKSSFLGPLGV---SYVELVPAEHPQFSAPVSL-CDLQGRDLHSSRT--GSSSA
YYALA--TD-LP----GVLDAVEAQEAQEA-DANSFSWNLRERFFSEWTDRTSSNCSCAT
SELTGTTSPLLVGSDVDVSS----------LQGQSSDVL--DDRELLLLTG-TCFGL-GE
GRRFRER--CLGLDGTEPSETCVLSSEHYEVNGRESPGCVPPVSG-ASPVDACPSEEPRL
GKIQVTSTPVKGDS--SVTPGATSLQHEIQEGTYAGSCYHRDGSR-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSSHSM-CELPGSSLGEML--KT
KSWLEESPKAVELEGLAACEGAYSHKYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1607)

SPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPRFGKVTLEIAILSRVQHANIIKVLDVFENQEFFQLVMEKHGSG
LDLFSFIDHHPSLDEPLASYIFRQ-------LVSAVGYLRSKSILHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETMEAAITPPYLVSEDLMKLVSGLLQPVPEQRTTLEKLVGDPWVTQPVNLAN
YTWDEVYRVNKP-ESGVLSTASLE--ME----SRSPSEVAQAPEL---------------
--------------------------------------

-----------MEDR-GP-PVFAEDWKCLSESPPVQ---EGPAAQA-TFEPSKPLSIAHK
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CAAAPEYADPTAGPLG
STSCCSLLRGLASGCSGSLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRIGEKIPVSVWIKRLQQD
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGRAV-
-AD------SE--AASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 459)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHYMDLTYD-SSVQLPDLVNCLDIG

ENSGT00760000119045_0_Linker_2_3 (459, 1347)

RKSGPGEMNSDA-QHNWELASG
AQ---GPRIDV------VLARDHMPSQD------E-TLKLVGG---Q-VSSRTQTRL-ET
GYK--ILPS---------S--ACQPSL--------------------GVDSNPED-----
-------GEQSLLTDQQ--------------------SIPKRNLPAHGGQ----NQLD--
----------TSEISLPVLKEHLLSEIQKNISEESPLTHRKWL-----------------
--SKVQQNPTKGSLPIHEE-------------------QLLFAGQ----------HIHVL
GKEDPS-AAESYR---------ESLLEESK----SKPVDAKLFA--SCEDSEPLVSVKDR
GSSVDTCNLH--QEAQLELMGVS---SPNPW---ADATMPEPHTTGQIAGG-SLTYCPQY
RSEWASQQRGQDSAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSCEGNLGI---SRVELVPEEHPPFTAPVSF-CDLGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QEA-DVNSYSWNLKELFLKDQTDRTPSHCSCTT
SELSEAPSLSVVGSDLDVGI----------LHRQTSDIL--VDREMLLLTG-TYFDL-SE
GQRFQEM--GAGHDRAELSNISLVSSEHYETSDIESPGCDPPLPD-PGPNDMCLSAEKPR
PSAQITSTP--------VARGATSLQQEIQEGIYSGSCYHRDGLQ-----LSIQFEVKRV
ELQGSATLFCCWLVKDLFHSHR-DSATRTRLFLASLPSSTHSM-PELSGSSFGEVL--RA
KPWFEESPTPAELEGLAACEGEYDYK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTISPLGS-GAFGFV---WTAVEKECN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSG
MDLFAFIDHHPCLDEPLASFIFRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLAS
YTWEEVCRTNQP-ESGLLSAASLE--IG----SRSPSEMAQREGLC----GPPAPRETRG
DQHCLHLKDPSLPVS-----------------------

-----------MEDP-SP-PDVNENGRCQSGSVSVPSPAEGPSTQA-ASEPSKPL-STRR
HLSRKDGLSKLCQSRIALS-EDRWSSYCLSSLVAQNICTGRVR-CPTAPEHVDPA-APLG
SASCCSLLRGLSSGCSMPLLPGPVYNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 246)

AIFTVDAKTTEILVANDKACGLLGYSSHDLI
GQKLVQFFVQPDSEVAEALSEEHVEADGHAAVVFGTVADIVSRSGDKIPVSVWMKRVRQE
RGLCC

ENSGT00760000119045_0_Linker_0_1 (246, 263)

VVVLEPVERISAWVAFQ

PF13426 // ENSGT00760000119045_0_Domain_1 (263, 355)

GEGTITSCDDLFAHL----------------HGFSSGE
DVVGQHITDLIPSLRLPSPGQPVPENLKIQRSVGRAKDGTTFPLSLKLKP--KQ

ENSGT00760000119045_0_Linker_1_2 (355, 393)

DGEAA-
-E-------GE--AVPEQGYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 434)

LITLLPDGTIYGINHNFALMLFGYGKTE
LLGKKITFLIPGF

ENSGT00760000119045_0_Linker_2_3 (434, 1348)

YHYMDITYD-SSSQYP--SSCLDFSSENGHGEMTLDT-SQ-------
-----DPKFDS------VLAGHCVLPPD------I-MQKPVGS--QG-IAGGMQTQL-ET
GCQ--LPAT---------C--SPGSSP--------------------GEDSVLDGYPL--
-----AQDKRSLPTNQQ----------------------------------------S--
----------TPEEHVLAHEKQSPSENQQDVSEESPPTHEEWLL----------------
--RKDPQDSQDGSPPALSV-------------------RTLPRDQ----------QDTAL
GSVGPV-VAQSSP---------QDLLGESG----SEPADTKPF--VSCEEPNPPVPPEDK
CSNVGMGSLH--QEAQWALTA---------------ASRPEPHAAGQPAGGDLLTYCPAY
RSEWLP---------WPPGHSGVACVSFGTPTLDEPWPGRRAS-HEEL---------QVC
LVKEQLSRLSFEGV------SRLESVPTEHHPYTASLS--SSLEGRDLCGSHL--GSSSA
CYALA--TD-LP----DALELVEA---REA-AMNSYSWNLRELLLSDDTDGTSSNCSYTT
SEPGGSPSPSAVSSDFNVHT----------LHKQRPGAF--GDRERLLLTG-TYFNL-GE
GQGSQES--NLEHDSTELPVMDLA-SERYKMSNSQS--SELPAMD-ASQEDARASAEDPK
LSAWVTSTP--------VKPGAASLCREIQEGTYSGYCYHRDGLW-----LSICFEVKLV
ELQGPVSLFCCWLVKDLLHSHR-SSATRTRLLLASLPSSTHSM-PDPSGRGLGEVL--RT
KPWAEEAPTPMELEGLAACEGEYSRKY

PF00069 // ENSGT00760000119045_0_Domain_3 (1348, 1612)

ITLRPLGS-GAFGFV---WIAMDKEQN-KEVVV
KFIKKEKVLEDCWIEDTKLGKVTLEIAILSHVEHPNIIKVVDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASHIFRQ-------LLSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEATIHPPYLVSQELMSLLSGLLHPDPRQRTTLEKLVTDPWVTQPVNLAQ
YTWEEVCRISKP-ESGLLSTASLQHRTG----SRSLSEAG--SEFQ----AHPAPEEAPS
SQHCLGPEDPSPLAS-----------------------

-----------MEDG-GS-TASVEDHQGPGGSPSLPVPLEGPTAPA-ALEPGKSGSSAHR
HVSRRTGLSKLCQSRMALS-EERWSSYCLSSLAAQNICTSKLH-CSAAPGQADLT-GSLG
STSCCSLLRALSSGWSTPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 234)

AVFTVDAKTTEILVANDRACRLLGHSSHDLI
GQKLTQFFLKPDPDMVQALSEEHVEADGHAAVAFGTVVDVVSRSGERIAVSVWMKRLKQQ
RSPCCVVVLEPVERVSAWVAFRSDGTVTSCDGLFAHL----------------HGFASGE
EVVGQHITDLIPSLQLPPPGEHVPMHLKIQRSVGRARDGATFPVSLKLKS--QPGSKEA-
-AD------GE--ATPSGGYSASVWVFSTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 441)

LITLLPDGTIYGINHSFALMLFGYGRAE
LLGKNITFLIPGFYHQMDLA

ENSGT00760000119045_0_Linker_2_3 (441, 1347)

YD-SSLPLRDLASCLDAGSRSGPGVSTGDE-PAGTAQDPK
VDTETPK------------PAE----SQ------D------------------TCPT-AP
G-----------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------GSLPACPLAR
SLPECPRDVPEGAPSA-------------------RSGPSSPEGQ----------QHSVS
EQEQLA-TAEHLS---------RGLQRGSQ----SELGDPKLS--ASQEDSEAAIPSADR
SSGDETHGPC--QEARAERGSARDSD---QG---PDVATAVPHTEGHLAGQ---------
--------GSPCLAPSPP---GTLQLLFSTPPLDEPWLEARQD-REEL---------HTC
LIKEQLSASSLAGPWGV---SYAELVLMGQPPLSAPASL-SGLRATAPRGGRS--GSSSA
CYALA--TD-LP----GALEAVAA---PEA-SEDSFSWNLKELVFRDCTDRTPPDCPCAT
SELGGTPLPSLLGSDAGVGA----------LHRQRSDVL--GDRELLLLTG-TCVDL-CG
GRRFRES--RLGLEETEPSPTCLVSSDHQDVNGRDSPSCVLPVLA-AGPEDECPL-EVPG
LSLHVTSTP----GPGPAPLRAADLQPEIQEGTYAGSCYHRDGGLVLPPSTGVQFEVRRV
ELQGPATLFCCWLVKDL---------LRTHLLLASLPSSAHST-CELPAASLGEVL--GT
KPWFEEPPKAVEPEGLAACEGAYSLK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPIGS-GAFGFV---WTAVDKEAN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILCKVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASYIFRQ-------LVAAVVYLRSESILHRDIKDENIVIAEDF
SIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSMGVTLYTLIFE
ENPFCELEETMEAAINPPYLVSEDLMNLMSGLLQPVPEQRTTLEELVTDPWVTQPVNLAD
YTWEEVCRLNKS-GERRSCSWQALFWKG----GGVPGS---GPALT----SQECGG--GL
R---PGPPRPPDPI------------------------

-----------MEDR-SS-PALEEDHRR-PGGLSVPAPPEDLAAQT-TSEPSKSLSAARR
HLSRRNGLSKLCQSRMALS-EDGWSSYCLSSLAAQNLCTSKLH-CPAAPEQVDLA-SPLG
SASCCSLLRGLPSGWSAPLFPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 238)

IFTVNAKTTEILVANDKACQLLGYSSHDLI
GQKLTRFFLKPDSHVVEALSEEHVEADGHAAVVFGMVVDVVSRGGDKIPVSVWMKRMRQA
CSLCRVVVLEPVERLSAWVAFQSDGAVTSCDALFAHL----------------HGFASPE
AVVGQHLADLIPSVQLPPPGEQVPESLRIQRSVGRAKDGTTFPLSLKLKA--QPRSQEA-
-AD------GV--AAPGGGYRASVWVFSTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LITLLPDGTICGINHNFALMLFGYGKAE
LLGKNITVL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYRGMDLACD-GSLPLPDLAPCLSAGSQRGLGEASRDL-LQGWDPAGT
AK---DPGEDA------E------------------TTDAAQ--SRG-ASPGAWAHA-DA
GGR--P-PT---------A--ALQALP------------------TLGTGLAPEESHP--
-----AHGQQSSPEDQQE---GSPPA----------------------------------
------------------Q-EQSPPEGQQNVPAR---CCGP-------------------
--------------------------------------WPPLEEQ----------QRPAL
EKQQLA-AAEHHR---------QDLPGGNR----SDPVAAKPV--ASHEDSGPPVPASSR
SSDGETCGLC--LEAQPGPGGSSSASSSIRG-----AD----VAESWPAG-----EGPRS
EGEWCARRGSPGPAPCPP---GMVSRLSSTPLLDGPWLETEEH-GEEL---------QVG
LIKEQLSMPSSVGPRGT---SYAELVLAGRSLASASVSL-CDPGGTDLHGGRS--GSSSA
CYALA--TD-LP----GALDAAEA---REA-GENSFFWNLKELSLSEGTDRTPSNCSWAT
SERGGTAPPSLAGSDMDVSG----------SRGRRPDAL--DDRERLLLTG-AYFDL-GE
GRWFRES--CLGRDGAGPSATCLVSSEQYAASGRERPGCVSPVLG-GGPTDVCPL-EVPR
LSPQVTSTPVRGDS--SATLRATGLQHEIQEGTYVGSCYHCDGSQ-----LSVQFEVKRV
QLQGSATLFCCWLVKDLLHSHL-DSALQSHLLLASLPSSAQST-CEPQVSGIGEAL--GT
KPWFEEHSRAVELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPIGS-GAFGSV---WTAVDKEAN-KEVVV
KFIKKEKVLEDGWVEDPTLGRVTLEIAILSRLQHASIIRVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPNLDEPLASHVFRQ-------LVSAVGYLHAKSIVHRDIKDENVVIAEDF
SVKLIDFGSAAYVESGRLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAVISPPHPVSDDLMNLISGLLQPIPEQRTTLEKLAADPWVTQPVNLAD
YTWEEVCRVNKPVCH---------------------------------------------
--------------------------------------

-----------MEHR-GV-MAFEDDRRCLSGSLPLPEWAQGPAAQA---VLSKSLSPARM
HLSRKNGLAKLCRSTTALS-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----
--XX-XXXXXXXXXX-----XX-X---XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX
XXXXXXXXXXX--XXXXX----XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX
X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------XXXXX--
-XX-XXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX-
----------X-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XX---XXXXXX------XXXXXXXXXXX------X-XXXXXXX---X-XXXXXXXXX-XX
XXX--XXXX---------X--XXXXXX--------------------XXXXXXXXXXX--
-------X-----XXXX------------------------XX-------XXXXX--X--
------------------X------------------XXXXXXXXXXXXXXXXXXXXXXX
XXXXXVDSITEGSP-------------------PTLSGESLSRGQ----------QDTAL
GKEEPA-VTESPK---------QDLGEGEG----SQPVNETPF--SPCEDPATLIGTEDR
GSSAQMWVLF--QDTEQELRAPG---------------DARPQAMGPPGVAGCLTHCACF
G---------------------RAPPWFGTPAVDAPWPGMGSD-REEL---------ETC
LIKEQLAQTASTE------GGCWAEPPAEQPSFGAPWAP-GDLGGRDLHGSHA--GSSSA
CYALA--TD-LP----GVSDGAKV---QAA-DMSSLSWDLKELFIKQ-------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------FVRRV
QLHGSAT---FWLIKDILHVHR-GSAIRTRLLLTSLPSSARSTYAELYGHSQGEVL--RT
KPWFEEPPEAGELEGLAACDGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1710)

YRTLRPLGS-GAFGFV---WTAVDKEEN-KEVVV
KFIKKEKVLEDCWIEDPELGKVTLEIAILSRMEHANIIKVVDVFENQAFFQLVMEKHGSG
LDLFAFIDCHPSLDEPLASYIFRQVRGQ-SHLVSAVGYLRSKNIVHRDIKDENIVIAEDF
TIKLIDFGSAAYLESGKLFYTFCGTIEYCAPEVLMGNPXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XX----XXXXXX-XXXX----XXXXXXXXXXXXXXX--XXXXX
XXXXXXXXXXXX--XXXXXXXXXX------XXPASDSERRSPREPC----GAPASRGSPG
RLPAMAR---------CQ-----------LRR------

-----------MEDR-GLT-AFEEDQRCFSQSLPLPVPAEGPAAQT-TAKPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEPTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
HHLCCVVVLEPVERVSTWVAFQSDGIITSCDSLFAHL----------------HGYVSGE
DMAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPNSEEA-
-TT------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLVSCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VFADGHIVPQD------E-TQKLVES--QD-IFTGTQTDL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEAQLERMGVSGPSGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTECPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGPEAVEA---QEV-DMNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTRSSLAVGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLERDPTEPLEVCLMSSEHYAASNGESPGHVPSVLD-AGPEDACPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLMKDLLYSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--SA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRVLTS-----------------------

-----------MEDP-GP-PPVGEAGRCLLGSVSASTPAMGPTAQD-ASTPSKLL-SARR
HLSRKNGLSKLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLR-YPTAPEHVDLA-APLG
SASCCSLLRGLSSGCSVPLFPAPVYNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 246)

AIFTVDAKTTEILVANDKACGLLGYSSHDLI
GQKLVHFFLQPDSEVAEALSEEHVEADGHAAVVFGTVVDIVSHGGEKIPVSVWMKRVRQE
RGLCCVVVLEPVERISAWVTFQSEGAITSCDEIFAQL----------------HGFSSGE
DMIGQLITDLIPSMRLPPPGQPVPENLEIQRSVGRAKDGSTFPLSLKLKP--KRGEEAV-
-AK------GK--AALEQGYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 434)

LITLLPDGTIYGINHSFALMLFGYEKAE
LLGKNITILIPGF

ENSGT00760000119045_0_Linker_2_3 (434, 1347)

YHYMDLTYD-SSLWQPDLTHCLDPGSESGHREMTSDP-SQGETRPP-
AP---NPKVDP------VVIGD-PVPQD------E-ARKLVGS--QE-VSARMQIQL-ES
GHC--LPAA---------C--PPRLSP--------------------GADSVPEGHPL--
-----AQDKRSLPTDQQ--------------------SIPEGHVPA--------------
------------------HEKQSPSENQQDISEESPPTCGEWVL----------------
--PKDPQDSPKGSPPACGV-------------------GSLLRDQ----------QVTAL
GRVEPA-IAQTYM---------QDLLGESR----SEPADVKPF--VSHEDSGSPVPPEHR
NSDVGIWGLH--QEAQWALRDTSSTS------PQAGATRPELHAAGHPAGGAPLTYCPHY
RSEWLLQPLSPDSVPSPS---GAACVSLGTPTLDEPWPGGRAS-HEEL---------QMC
LVKEPLSRLSSERALGI---SHLEPVPAGHRPYTASQT--SSLGGRDLCGSHL--GSSSA
CYALA--TD-LP----GVLEAAEA---WET-AVSSCSWNLRELLLSDDTDGTSSSCSCAT
SELGATPSPSAVSSDFDVGM----------LQTQRPGAV--GDRERSLLTG-TYFDL-GE
GRGSQES--CLEHDPTELPQMY-LSSEHYEAGNTEGPECVLPTVG-ACREDARPSAEDPR
LSAWVTSTP--------VTPGAASPCQEIQEGTYSGSCYHRDGLR-----LSIHFEVKRV
ELQGSSSLFCCWLVKDLLHSHR-DSATRTRLLLTSLPSSTHSM-PEPPGSGLGEVGVRSL
RPCLCVPSMPAELEGLAACEGKYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTVRPLGS-GAFGFV---WIAVDKEQN-KEVVV
KFIKKEKVLEDCWVEDPRLGKVTLEIAILSSVQHSNIIKVDDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMDAIISPPYLVSQELMSLISGLLQPAPEKRTTLEKLVTDPWVTQPVHLAD
YTWEEVCRTNKP-GEGLRSAASLEHRTG----SRSPSEAAQGE-AP----GAFYPAEAPS
SQHGTSPEDPVPLAS-----------------------

-----------MDDP-GP-LPVDEDSRCLSGNVSVPVPAKGPSALD-TSEPSKLL-SARR
HLSRKDGLSKLCQSRVALS-EDRWSSYCLSSLAAQNICTSKLC-CPTAPEHSDPA-APLG
SASCCSLLRGLSSGCSMPLLPAPVYNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACGLLGYSSHDLI
GQKLVQFFLQPDSEVAEALSEEHVEADGHAAVVFGTVVDIISHSGEKIPVSVWMKRVRQE
RGLCCVVVLEPVERIAAWVAFQSEGTVTSCDDLFAHL----------------HGFSSGQ
DVVGQLITDLIPSLRLPPAGQPVPENLEIQRSVGRAKDGTTFPLSLKLKP--KCGEEAV-
-AE------GE--AAPAQGYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 436)

LITLLPDGTIYGINHSFALMLFGYGKTE
LLGKNITFLIPGFYH

ENSGT00760000119045_0_Linker_2_3 (436, 1347)

YMDLTYN-SSLQQPDLTSCLDVGSGSGCGEMTLDP----------
SQ---DPKVDP------VLAGDHVLPQD------E-TRKLVGS--QE-VSGRMQTQL-EA
GCW--LPAA---------R--PARSSS--------------------RADSIPEGHPL--
-----AQDKQLLPTDQR--------------------SVPEGHVPA--------------
------------------HEKQSPSENQQDASEESSPSPGERVL----------------
--PKDPQDSREGSPPALGA-------------------GSLLRYQ----------QFAAL
GRAEPA-VAQICL---------QELLGESR----SEPEDKIPF--VSCEDPSSPVPPEDR
SSDIVMWGHE---EAQRALMAASSAS------PQAGATRPEPHTAGQPAGGGLLTYCPHY
RSECLLRPPSPDLAPSPP---GVACVSFGTPTLDEPWPGGRAN-REEL---------QVC
LVKEQLSRLSFGRALGI---SRLEPVPAEHRPCSASLS--SSLGGRDLRGSHL--GSSSA
CYALA--TD-LP----GVLEAVEA---REA-TMNSCSWNLRELLLSDDTDGTSSSCSCAT
SELGATPSPSAVSSDFDVDM----------LHRQGPGAL--GDRERLLLTG-TYFDL-GE
GRGSQES--CPEHDPTELPEMY-LSSEHCEASNTESPGCVLPAVD-TCQEGTCPPAEDLR
LSAWITSTP--------VTPGAASPCREIQEGTYSGSCYHRDGLW-----LSICFEVKRV
ELQGPTSLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSTHSM-PEPPGPGLGEVL--RA
KPWAEEAPTPVELEGLAACEGEYSCK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTQRPLGS-GAFGFV---WIAVDKEQN-KEVVV
KFIKKEKVLEDCWIEDSKLGKVTLEIAILSSVEHSNIIKVVDVFENPGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEATIHPPYLVSQELMSLISGLLQPAPEQRTTLEKLVTDPWVTQPVNLAK
YTWEEVCSTSKP-ESGLLSTGSLECRTG----SRSLSEAAQAPRFQ----GGPDPEEASS
GHHCSGPEDPSPLAS-----------------------

----------------------------------------------TVAELSRLFPRVFQ
HLSRKNGFTRLCNSKKSLTXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX--XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXILVVNDQACELLGYCDQELI
GQRLSSFFSKSSTSVVEALINESGETDEKDVIAFGTVVDLICSNKEKIPVSIWMKNLEHD
FSPCCVVLLEPVERFTVWVTFQSDGTVVSCDHLFAQL----------------FGYSSLE
EVIGNSILELIPSLQMPLQGQWVTEDLQIQKLTGRAKDGSAFPLSLKLTSYEEEEGLE--
-------------ASSLHIYSASLWIFTTISGLITLLSDGTIYGINRNFALTLFGYEKAD
VLGKNITFLIPDFYNYMDLVEN-SSCHRSAATSS-ERTNENKAEEXXXXX-----XXXXX
XX----X-XXX--------XXXXXXXXX------X-XXXXXXX--XX-XXXXXXXXX-XX
XXX--XXXX---------X--XXXXXX---------------XXXXXXXXXXXXXXXX--
-----XXXXXXXXXXXX------XX---------------XXXXXX----XXXXXXXX--
---X-----------X--X----------XXXXXXXXXXXXXXX----------------
--XXXX------XXXXXXX-------------------XXXXXXX----------XXXXX
XXXXXX-XXXXXX---------XXXXXXXX----XXXXXXXXX------------XX--X
XXXXXXXXXX--XXXXXXXXXXX-------------X----XXXXXXXXXXXXXXXX--X
XXXXXXXXXX-----XX----XXXXXXXXXXXXXXXXXXXXXX-XXXX---------XXX
XXXXXXXXXXXXXXXXX-----X----X--XXXXXXXXX-X--XXXXXXXXXX--XXXXX
XXXXX--XX-XX----XXXXXXXX---XXX----XXXXXXXXXXXXXXX------XXXXX
-XXXXXXX-XXXXXXXXXXX----------XXXXXXXXX--XXXXXXXXXX--XXXX-XX
--XXXXX---X--XX-X--XX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLENQT
LNAQASSTPVKMKA--------TTLPLEIMEGTYLGTCNHKDGVK-----LSIQFEIKHV
ELKGPADLFCCWIVKDFFQSHR--SIGRAQYLFSSFCSSSQSL-FEEPMISMGEXXXXXX
XXXXXXXXXXXXXX--XXXXXXXXXXXXXX-XXXX-XXXXXX---XXXXXXXXXXXX

PF00069 // ENSGT00760000119045_0_Domain_3 (1378, 1537)

VVV
KFIRKEKVLEDCWVIDPELGKVTREIAILSRMEHPNIIKVIDVFENEGFFQLVMEKHGSG
MDLFTFIDSHPSLDEPLASYIFRQVRTGLCEVVSAVVYLRSQNVIHRDIKDENIIIAEDF
TVKLVDFGSAVYMEPGKSFYTFCGTIEYCSPEVLMGH-----------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSRSFSSAQR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSQLH-CPAAPEHTDPS-GPRG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQE
HRLCCVVVLEPVERVSTWVAFQSDVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXH
LHGYQHITDLIPSVQLPPPGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPSSEEV-
-TT------GE--AAPARGYQASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGERTLDP-WQGQDPAEG
AQ---DPRINV------VLAGGHIVPRD------E-TRKLVES--QD-IFTGTQTEL-GA
GGQ--LLSR---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQVLPEDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPR---------QGLLGESR----SEPVDVKPF--ASCKESEARVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSSSDLW---AGAAVAEPQAKGQLAGGSLLMHCPCY
GSEWGLWR-SQDLAP------------------NEPWLGVKND-REEL---------QTC
LIKEQLSQLSLAGALDV---PHAELVPTECPAVTAPVSS-CDLGGRDLYSGCT--GSSSA
CYALA--TD-LP----GALEAVEA---QEV-DVNSFSWNLKEPFFSDQTDQTSSNCSCAT
SELRGTPSSLAVGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRDS--CLGQDPTEPLEVCLVSSEHYAASDRESPGRVPSTLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMCGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRVNKP-ESGVLSTASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
SQGCLHPGDPRLLTS-----------------------

-----------MEDG-GP-P-------------------ESLAAQT-TCEPSESLSSAHR
HLSRRNGLSKLCQSRTALS-EDRWSAYCLSSLAAQNICTSKLH-CLVAPEQTEAA-GSLG
SMSCCSLLRGLSSGWSTPLLPALVCNPNK

PF13426 // ENSGT00760000119045_0_Domain_0 (150, 248)

AVFTVDAKTTEILVANDKACQLLGHSSHALI
GQRLTRFFLKPDSDVAKALSEEHVEADGRAAVVFGTVVDVVSRGGEKIPVSVWMKKVKQE
RGPCCVVVLEPVERVSAWVTFQSDGTITSCDSPFALL----------------HGFVSSE
EVLGQRVTDLIPSVQLPPPGEPVPQNLKIQRSVGRAKDGTTFPLSLKLKS--ECGGEAV-
-GG------SR--AVPECSYSASVWVFSTISGLITLLPDGTIYGINHSFALMLFGYGRTE
LLGKNITFLIPGFYHYMDLVCD-GSLPLPDLAERLDIGTQSGPGETSAGP-WQGQNLAGT
AS---GPRAGG------TLAGDRAQPQG------E-APERGGA--PE-AVVGTQAAL-DP
GDC--LPPS---------L--PRLPTP------------------TLGVENIPKGSSS--
-----AHRQQSSPKDQQDIPGGSPPAHRPQSSPEDQRDIPDGSPPAQRQQSSPKDQQD--
----------IPDGSPPAQRQQSSPGDQRDIPGGSPPAQRQQSS----------------
--PRDQQDIPGGSPPAQGWSSPEDQRDIPGRSPPAHNQQSSPKDQ----------WNTLL
GQEEPA-APESLR---------QDLVGRSR----CDPVVTWMF--ASQGGPETPALAEGR
SRNAELCGLY--QEAQLEWTGLSSASSSNRR---ADSVMPEPRAAGQLAAEGLPMPYPGY
GGEQSTQPGS------PP---GTARLLFSTPTLDEPWVAVEND-REEI---------QTC
LLKEQLPRLSFVGPLGV---SYSELASAEHPPLPPPVSL-CDPGGRDFCS-RV--GSSSA
YYALA--TD-LP----GVLDAVQA---QEA-DGNSFSWNLKELRFSEWADGTSSTCSCAA
SELVGTPSPSPAGSDVDVSG----------LHGRRPDVL--DDRELLLLTG-TCLHL-GE
ARQFHES--RLGPDRVELSETCLESSERGGGRSRESSPCVLPAPE-AGPVDVCPS-EEPR
LSFQVTSTPVRDDS--LVAPGDMCTQHGIQEGTYAGSCYHRDGAQ-----LSVQFEVKRV
ELQGAATLFCCWLVKDLLHGPR-DSATRARLLLASLPGSSHSV-CEASGSSVGEGL--RS
KPWFDDAPRAVELEGQAACEGAYSHKYL

PF00069 // ENSGT00760000119045_0_Domain_3 (1349, 1612)

TLSPLGS-GAFGFV---WTAVDKEAN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASYIFRQ-------LVAAVGYLRSKSIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLMGNPY-KGPELEMWSLGVTLYTLIFE
ENPFCELEETMEAVIHPPYLVSEALMHLISGLLQPVPEQRTTLEKLVTDPWVIQPVNLAD
YTWDEVCRVNKP-ESGALSTVSLE--LE----GRCAGELAWAAGPG----GPLCPRGGP-
--------------------------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGLAAQT-TAEPSESLSSAHS
LPSRRNGFSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQNLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKHLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 393)

PLSLKLKS--QPNSEEA-
-TT------SE--AAPARGYWASIWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LITLLPDGTIHGINHSFALMLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRINV------VLAGGHIVPQD------E-TQKLMES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQVLPEDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AMECPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLERMGVSGPGGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTPSSLAVGSDPDVAS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVGLVSSEHYVASDGESPGHIPSVLD-AGPEDTCLSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCFHPGDPHVLTS-----------------------

------------------------------------------------------------
------------------------------------------------------------
RVTTTEPLTGDARGCAGKG------------QALGPLLP

PF13426 // ENSGT00760000119045_0_Domain_0 (160, 241)

PILVANDKACSLLGYSSHDLI
GQRLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQE

ENSGT00760000119045_0_Linker_0_1 (241, 263)

RGLCCVVVLEPVERVSAWVTFQ

PF13426 // ENSGT00760000119045_0_Domain_1 (263, 316)

SDGTITSCDSLFAHL----------------HGFTSPK
DVVGQYVTDLIPSMQ

ENSGT00760000119045_0_Linker_1_2 (316, 393)

LPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKS--KANGKAE-
-AE------SE--AASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 436)

LITLLPDGTIYGVNHSFALMLFGYKKTE
LLGKNITFLIPGFYH

ENSGT00760000119045_0_Linker_2_3 (436, 1347)

SMDPACD-SSVQLPDLVNCLDIGSKSGPGEMSSDV-QQDWELASG
AQ---GPRVDA------VLARDHMLSQD------E-TLQLVGG---Q-VSLRTQTRL-ET
GCQ--ILPS---------Y--SSQAAL--------------------GVDSNPVY-----
-------GERSLPTDH-------------------------------GGQLLSQNQQD--
----------TPEESPPVLNEHLLSEIQKNTSEESPLTHRKWLL----------------
--PKAQQDTTEGSLSVLNE-------------------QLLSAGQ----------HISVS
EKETPP-APESYG---------QGLLEESR----SKQKDAELFA-SSCEDSEPLVPVKDR
SSSMDVCSLH--QEAQLELMGVSSPSSPNLW---VDATMPEPHTAGQLAGGGFLTHCPQY
RSEWLLQQRGQDLASSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSIGGTLGL--SSCVELVPAEHPPFTAPVSF-CDLGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVET---QET-DVSSYSWNLRELFLNDQTDRTPSHCSCAT
SELSETPSPSVVDSDLDVGA----------LNRQGSDIL--GDREMLLLTG-TYFDL-GE
GRQFQEM--DAGYDRAELSGISLVSSKHYETSDIESPGHGPSVPD-PGPCGMCLSAETPR
LSAQITSTP--------VAPGAPVLQPEIQEGIYSGSCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLLHSHR-DSATRTRLFLASLPSSTHSM-PELSRSSIGEML--RA
KPWFEEAPTPAELEGLAACEGEYSLK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTISPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWVEDPKLGKVTLEIAILSKVDHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSEELMNLLSGLLQPSPEQRTTLEKLIIDPWVTQPVDLAN
YTWEEVCRINQPGESGLLSAASLE--LR----SRSQSSVTHRKGFD----GP-SPREAPS
DQHCLHLEDPSLPVS-----------------------

-----------VEXXXXX-XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-XDRWSSYCLSSLAAQNICTSKSH-WLAAPAQADLA-GSLG
STSCCSLLQGLSSGWSTPPLPAPVCNPSK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 193)

AVFTVDAKTTEILVASDRACRLLGYSSHDLI
GQKLTQFFLKPDSNVARALSEEHVEADGHAAVVFGTVVDIVSRSGEQIPVSVWMRRVKQE
HGLCCVVVLEPVERVSAWVAFQSNGTVTSCDGLFAHL----------------HGFTSVE
EVVGQRITDLIPSVQLPPPGEHIPKNLRIQRSAGRAKDGTTFPLSLKLNS--EPGSEEA-
-AD------GE--AAPDWGYSASVWVFSTISGLITLLPDGTIYGINHSFALMLFGYGKDE
LLGKNITFLIPGFYHYMDLACD-SSFLLPDVANCLDAGSHSGPGEATRDAQHTAEGXXXX
XX----XXXXX-----------XXXXXX------X-----XXX-----XXXXXXXXX-XX
XXX--XXXX---------X--XXXXXX---------------XXX---------------
------------------------------------------------------------
------------------------------------------------------------
--XXXVDGTPEGSPPAHGE-------------------QSLPEDQ----------QSTVL
EEERLA-TAESLR---------QDLLGGNR----SDPVDTRPC--ASHEDSETPVPSTDG
TSGAGRGGLY--QETQLGRRGSSGTSDSNHG---ADATKARPHAAGQLAGQGLPVRGPGF
EAEWSTQRGSPGSALSPS---GTVQPLLSTLSLDEPWLG-------------------TC
LIKEQLPAPSFAGPWGV---SCAELVPAEQPPPSAPASL-CDLGGTDPHGGRS--GSSSA
RYTLA--TD-LP----GTVEAREA-------GKNSFSWNLKELVFSEWTDRTSSNCSYAT
SELGGTRSPFAAGSGVDVSG----------LRRQRSEVL--DGRELLLLTG-TNFNL-GE
GRRFRES--CLGLDGTEPSQTGLVSSEHYDLGGRESLDRVPPVSG-AGPMDASLL-EAPR
LSLQVTSTPVRADG--SAPLGAADLQHEIQEGAYAGSCYHRDGSQ-----LXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX--XX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX---XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLVSAVGYLRXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXY-KGPELE

PF00069 // ENSGT00760000119045_0_Domain_4 (1547, 1612)

MWSMGVALYTLIFE
ENPFCELEEALEAAINPPYLVSEDLMNLMSGLLQPVPEQRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRLNKP-ESGVLSTGSLEL--E----SRSPSAVAQAPELRRASVRGQAPNGEPS
SL------------------------------------

-----------MATQ----DCVSSEDGCLCTSLGLPFPGLSDSD-----ELSRSYP--WT
IKCRKSGLSRLCQSKTSLS-EDGWTSYCLSSLAAHTICSGKLGNSWAHLDLSSLS-HSIS
STSSFSFLNVLNVEESLQSLPAAVR

PF00989 // ENSGT00760000119045_0_Domain_0 (146, 246)

NPNQAIFTVDVRTTEILIANDKACKLLGYSSQELI
GQKLSQLISKCTRGVVEALAEEHVEANGCAAMVSGTVVDVIDRSNEKIPVSVWMRRMRSE
EKWCCVVVLEPVEKLSASVSFKSDGEIISCDLLFAHL----------------HGYTSLE
EIVGNDIKDLIPSLQIPPPGKQIPKNLKIQRSVCRAREGTSFPVSLKLRASFPDEVQVPV
IEDGL-LQECKTGSCTDCSYSATLWVFTTISGLITLQPDGTIYGINNSFASILFGYEKKE
LLGKNITFLIPGFYNHMERIDY-SSLPFPPLDDCMKAENGRTSGDVKRAQ-LGDCCITDR
-----SEGASH------LLAGDAVLLLC------E-KQKLARSQAKE-IFTRAETQL-DG
GSN--VPPT---------L--SSSAVT---------------STHFCGVDCIAAGGLP--
-----ATDEEPLPESQHEEI----------------FTVTETAKPNNSSQSLSAA-----
----DALKPSDPEQSVLGQS----------------------------------------
--T----------------------------------------------------EVPVR
VCNGPV-ASETLQENIDVIGSLSDLLQEEQ----NVLVDLDRQ-----LGS--GLPH---
-DETRKCQSS------IEA----------------------LGKAASVLGSQMPVPC---
RLEDSLETETSDLNRSL---CDATCLSLGTPTLDEPRCGATSYCRQNV---------QVH
VITEQFTNTNSMSGTRN---ASFEQVTLDSSRLTSCSPF-LPVGRSNIQDVCS--GSLLT
CDASA--LG-AS----STFNKSQE---PGT-EVNCVCDGLSELNLNIDTELTSASCSDAT
SGLPWTPLPSVMNCDLDVGS----------LLARKTSSSTSEQDEPPLNSP-------KG
GQGWVNSRRHLKNAQRDSSRAS----PSVPNSAAEN--TGSPLSSDVNPQEDSLLSKQQN
LEMQVTSTPVKAEA--KFSPSVPLLTSEILEGSYAGNCYHRDGSR-----LSVLFEVKRV
ELQDPAALFCVWVARDLLWNQN-AAARRTQLLLSSLASSSPSG-GELSALSLGEAI--RT
RPLFENSQRAEELESLRANEGEYAKKYDTIC

PF07714 // ENSGT00760000119045_0_Domain_3 (1352, 1607)

LIGK-GAFGFV---WTARCKKDK-KEVVV
KFIWKEKVLEDCWVEDPELGKVTQEIAILRKLHHPSIVKVQDVFENGRFFQLVMEKHGSG
LDLFTFIDNRPDLDEPLASYIFRQ-------LVSAVGYLHCRNILHRDIKDENIIIAEDF
TIKLVDFGSAAYMESGKLFYTFCGTVEYCSPEVLAGNPY-PGPELEMWSLGITLYTLVFG
ENPFCELEETMEAVLNPPGHVSEDLMVLLSGLLHPAPEQRTTLQKLLVDPWVLQPVNLAN
YTWEEVYVWARP-ESNDFGNHCAEQS------HSEPGESAETKP----------------
--------------------------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVSAEGPAAQT-TAEPSRSFSSAHR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPS-EPRG
SVSCCSLLQGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVCGTVVDIISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 358)

QSDGTVTSCDSLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPSSE

ENSGT00760000119045_0_Linker_1_2 (358, 394)

EA-
-TT------GE--AAPVRGYRASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVGDESGCGERTLDP-WQGQDPAEG
AQ---DPRINV------VLAGGHVVPRD------E-TRKLMES--QD-IFTGTQTEL-GA
GGQ--FLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPEDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ITAL
GREEPV-AIESPG---------QDLLGESS----SERVDVKPF--ASCEDSEAPVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSSSDLW---AGAAVAEPQAKGQLAGGSLLMHCPCY
GSEWGLRWRSQELVPSPS---GMAGLSFGTPTPDEPWLGVEND-REEL---------QTC
LIKEQLSQLSLAGALDV---PHAELVPTECPAVTAPVSS-CDLGGRDLYGGCT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSCAT
SELREAPSSLAAGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CVGHDPTEPLEVCLVSSEHYAASDRESPGRVPSMLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMRGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSASRTRLLLASLPGSAHSTAAELTGPSLVEVL--RA
RPWFEEPHKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI-KVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCPVNKP-ESGVLSTASLE--MG----NRSLSDVAQAQELC----GGPIPGEAPN
GQGCLHPGDPRLLTS-----------------------

-----------MEDG-G-VTAFEEDQRCLSQSLPLPVPAEGPAAQT-TVEPSKSFSSAHR
HLSRRNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPWG
SVSCCSLLRGLSSGWSSPLLPAPVYNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWMKKMQQE

ENSGT00760000119045_0_Linker_0_1 (241, 262)

HRLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 325)

QSDGTITSCDSLFAHL----------------HGFTSGE
DVAGQHITDLIPSVQLPPPGQHIP

ENSGT00760000119045_0_Linker_1_2 (325, 393)

KNLKIQRSVGRARDGTTFPLSLKLKS--EPSSEEA-
-TT------GE--AAPLRDYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LITLLPDGTIYGINHSFALTLFGYGKSE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDFAYD-SSLQLPDLASCLDVSDESGCGETTSDP-WQGQDPAKG
SQ---DPRINV------VLAGGLILPQD------E-ARKLLES--ED-IFTGTQTEL-GA
GGQ--LPSC---------L--SPQPAP--------------------GVDSVAEGIPP--
-----AHGEQVPPEDQH-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ATAS
GREEPV-AVQTPG---------WGLLGGSR----PEPVDAKPS--ASCEDSEAPVPAEDG
GSNAGVCGLC--QQVQLELTGV---SGSDLW---AGVAVAQRQAKGQLVVGSLPMHCACY
RSEQGLLWRSQDLARSPS---GVAGISLGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSELSLAGALDI---PHTELVPTECPAFTAPVLS-CDPGGRDLYGGCT--GSSSA
CYALA--TD-LP----RGLEEVEA---QEV-DVNSFSWNLKELFSSDQTDQTSSNCSCAM
SELGGTPSSSAVGSDPDVGS----------LQEQGSCIL--DDRELLLLTG-TCVDL-GQ
GRGFRES--CLGHDPTEPSEVCSVSSEHYAASDRGSPGRIPSTLD-ACPENTCPSAEEPM
LDIQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPSPLFCCWLVKDLLHSHR-NSAARTCLLLASLPSSTHSTAAELTGPSLGEVL--RA
RPWFEDPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEQN-KEVVV
KFIKKEKVLEDCWIEDPNLGKVPLEIAILSRVEHANIIKVVDVFQNHGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDVIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSQELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAE
YTWEEVCRVNKP-ESGVLSTASLE--MG----SRSLSEVAQAQELC----GGLAPGEAPD
GQGCLHPRDPPLLTR-----------------------

-----------MEDR-GP-PAFDEDQRMLSRSLPVL---ESSTA-QTTSEPSKPLSSARR
HLSRKNGLSKLCQSRMALP-EDRWSSYCLSSLAAQNICTSKLY-CSTAPEHADLA-GSMA
STSCCSLLKGLSSGWSAPLLPAYVYNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDNACRLLGYSSHDLI
GQKLMQFFLKSDSDVMEALSEEHVEADGHAAVVFGTVVDIVSRTGEKIPVSVWMKRMQQE
RGLCCVVVLEPVERIAAWVSFQSDGTVAACDSHFAHL----------------HGFASGE
DVLGQHITDLIPSIQLPPPGQQVPKSLKIQRSVGKARDGTTFPLSLKLKS--KPSSEAA-
-AE------GA--AAQGLGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 434)

LITLLPDGTIYGINHSFALMLFGYGKME
LLGKNITFLIPAF

ENSGT00760000119045_0_Linker_2_3 (434, 1347)

YHYMDFACD-SSIYLPDLTNE------SGP------A-EPGWGLASG
AR---DPRADV------------VLPQE------E-TLKLVER--QE-VLPETQTQQ-ET
VRQ---PSS---------H--SCEPSL--------------------SGDGAPEGGFS--
-----AHSD------------------------------------------QSSEQQD--
----------LPEGSPLVHAEQTGSEKQQKSSEEIPLPHDEGSL----------------
--PEQHPGTTGGGPPVHTE-------------------QSLPAEQ----------CIPVP
GKENPG-VAESPR---------QTLSGESR----SPPADAKLF--ASRADSEPLLLAEDR
NSSMDLCGLR--QEAQWELLGISNPSSP-AW---ADATMPEPHAAGQPAGGGFPMHCPRY
ASEWVMQQRAQDLVPSSP---GMAGVSLGTPTLDEQWLGVKND-REEL---------QTC
LIKEQLSKSSFSGTLGI---SYVELVPAEHPPFATPVSF-CDLGGTDLRSSHL--GSSSA
CYALA--TD-LP----GVLETMES---QED-DVNSYSWNLKELFLSDQTEQASSNCSYAT
SELSETPSPSVVGSDLDMGG----------LRRHNPDPL--GDRELLLLTG-TYFNL-SE
GRQDP--------QSLEPPEVSLKPSKYYKASDLESSACILAIPD-TSPEAECPAVGEPG
LSTQVTSTP--------MTRRAASLQREIQEGTYSGSCFHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLLHSHQ-DSATRTRLLLASLPGSTHSI-HDISPSSPGEVL--RT
KPWFEEPPMPAELEGLAACEGEYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YHTLSPLGS-GAFGFV---WTAMDKEQN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSRVEHVNIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDHHPNLDEPLASYIFRQ-------LVSAVGYLRAQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEATLRPPYLVSQELMNLVSGLLQPAPEKRTTLEKLVQDPWLTQPVNLAD
YTWEEVCRISKP-EPHHLCTPSLE--VG----CRSPSQGPRD---------AGLPRAPSG
GQHSLGPEEPSPPVG-----------------------

-----MSLKIFLEDG----CIYAPTGFFLLGNIDIPF------E-ENCFNLNRLYPRVFQ
HLGRKNGFTRLCKSRMSLS-EDKWSTYCLSSLAAQNICSSRFN-IMPHSEHSDLT-GSIC
STSYCSLVNSLPSRSSIHSIGSSVYAPNRAIFILDLKTMMILVVNDQACELLGYSSNELI
GQPFSLIFSKPSTVIEEALSNECGETDGPNVIAFGTVVDIVCSNKEKIPVSIWMKKL--E
HGPCCVALLEPVERFTVWVTFQSDGKIISCDNLFTQL----------------FGYASLE
EVVGREIMDLIPSLQMPPPGQLVSEALKIQKLTGRTKDGNTFPLSLKLRSEALCKEEEE-
---------GQ-PEPSVFIYSASLWIFTTISGLITLLPDGTIYGINHNFALTLFGYEKEE
VLGKNITFLIPDFYNYMDLIEN-SSVPTLNITNPVDRRNENKTGKGREGG-KQKWNQADG
TE---DPGVNI------LHSANEFQQIL------EEDKKASGPLR---FPSKIEVLGEND
GNS--SPSS---------F--LPLEEI-----------------STPGVDS---------
------------------------------------------------------------
-----------------------------------PPTQEEQPL----------------
------------------------------------------------------------
-------PMRAPE---------------------EEHAETRMV------------PGQDA
S------GS------QKSLTGILK------------------------------------
-KEHSAQS--------------------------------KGD-PKKL---------NSV
VILEQST-------------------------FQSK---------------VL--DSSSA
SDPKENTSSVGPAITEGTRDEVHS-----------SEKHL--------------------
-----------VS-----------------------ETL---DPQTTLLPNADEQKR-SA
--GVEDI---QG--GSAPEDTSV---AH------TPPG--------YNINPLADTLGKQT
LNAQATSTPMKLGK---EQIPRISLQMEILEGTYTGSCYHRDGTK-----LNIQFELRHV
ELKGPADLFCCWVVKDFFPSSRQGLAGRTQCLFSSLNASSHSL-LEESRMGPSEF--RKQ
KEVIEEFFQSKDLGVLKAYEGDYSKR

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YTTVRPIGS-GAFGFV---WIAKSKEDG-TEVVV
KFIKKEKVLEDCWVTDPALGKVTQEIAILSQLSHPNIIKVVDVFENEEFFQLVMEKHGSG
MDLFSFIDSHPTLDEPLASYIFRQ-------VVAAVTYLRSKNITHRDIKDENIIIGEDF
TIKLVDFGSAVYMEPGKYFYTFCGTIEYCSPEVLMGHAY-SGPELEMWALGVTLYTLMFE
ENPFNELDEALEAILNPPFLVSPELLNLLCGLLHPQPEKRLTLDLVIQHTWVTQPVNLAN
YSWEEVCHVTIESECSI-------------------------------------------
--------------------------------------

-----------MEDR-GS-PVFAEDWKCLSESPPVQ---EGPAAQA-TFEPSKPLSIAHK
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLQ-CAAAPEYADPTAGPLG
STSCCSLLRGLASGCSGSLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQD
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGKAV-
-AD------SE--VASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 434)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGF

ENSGT00760000119045_0_Linker_2_3 (434, 1347)

YHYMDLTYD-SSAQLPDLINCLDIGRKSGPGEMSSDA-QQNWELASG
AQ---GPRIDV------VLARDHMPSQD------E-TLKLVGG---Q-VSSRTQTRL-ET
GYK--ILPS---------S--ASQPSL--------------------GVDSNPEG-----
-------DKQSLLTDQQ--------------------SIPKRNLPAHGGQ----NQPD--
----------TSEISLPVLKEHLLSEIQKNISEESPLTHRKWL-----------------
--SKAQQNRTKGSLPIHEE-------------------QLLFAGQ----------HIHVL
GKEGPS--AESYS---------EALLEESK----SKPVDAKLFA--SCEDSEPLVSVKNR
SSSVDMCNLQ--QEAQLQLMDVSSPSSPNPW---ADATMPEPHTTGQIAGG-SLTYCPQY
RSEWASQQRGQDSAPSPS---GMACVSLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSICEGNLGI---SRVELVPAEHPPFTAPVSF-CDLGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QEA-DVSSYSWNLKELFLKDQTDRTPSHCSCTT
SELSEAPSLSVVGSDLDVGS----------LHRQTSDIL--VDREMLLLTG-TYFDL-SE
GQRFQEM--GAGHDRAELSNISLVSSEHYETSDIESPGCDPPLLD-PGPNDMGLSAEKPR
LSAQITSTP--------VAHGATSLQQEIQEGIYSGSCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLFHSHR-DSATRTRLFLASLPSSTHSM-PELSGSSFGEVL--RA
KPWFEESPTPAELEGLAACEGEYAHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTISPLGS-GAFGFV---WTAVEKECN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSG
MDLFAFIDHHPCLDEPLASFIFRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIIDPWVTQPVNLAS
YTWEEVCRTNQP-ECGLLSAASLE--LG----SRSPSEMAQTEGLC----GPPAPRETRG
DQHCLHLKDPSLPVS-----------------------

-----------MEDR-GS-VVFEEDQRCLSGSLPLPAPPEGPAAQT-IFQPSKSFSWAHR
HLSRKNGLSKLCQSRMALS-EDKWSSYCLSSLAAQNICTSKLH-CPATLEHSDPA-GPPG
SMSCCSLLRGLSAGWSVPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVVNDKACRLLGYSGRSLI
GQRLTQFFLKSDSDVVEALSQEHVGADGRAAVAFGTVVDIVSRSGEKIPVSVWMKRLRQE

ENSGT00760000119045_0_Linker_0_1 (241, 263)

HSLCCVVVLEPVERVSAWVDFQ

PF13426 // ENSGT00760000119045_0_Domain_1 (263, 320)

SDGTITSCDSLFAHL----------------HGFVSGE
DVVGQHITDLIPSVQLPPP

ENSGT00760000119045_0_Linker_1_2 (320, 393)

GQHVPKNLKIQRSVGRARDGTTFPLSLKLKS--KTSCE-E-
-DA------SE--VDPEEGCSASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 433)

LITLLPDGTIYGINHSFALMLFGYGQTE
LLGKNITFLIPD

ENSGT00760000119045_0_Linker_2_3 (433, 1347)

FYRCMDLAYD-SSLQLPDPASCLDISSGRGPGEMLSDP-WQGWSPGG-
AR---DPRVNI------VLAGDHVLPQD------E-TLKLVVN--QE-VFTRTQTQL-ET
GGR--PPPS---------L--SSQSPS--------------------RVDTILE------
------------------------------------------------------------
---------------------------------GSPPACGEQLF----------------
--PEDQ-------------------------------------------------QIAAG
GREEPA-ATESLK---------QDLLGESR----SELVDAKPF--ASSEGSETPVPAEDR
SSDTGMCGLR--QEALLELVGLSGPSGANKW----AHASVEHQALGQPAGGGLPTHCPLY
GREWGLQRHGEDLAPSPS--EAVACVSFGTPTVDEPWLGAKHN-REEL---------QTC
LIKEQLSKSRSAGALGV---PSMELVPSESPPLTASMSS-YDLGGRDLHGSHA--GSSSA
CYALA--TD-LP----GGLQAVEA---QEA-DANSFSWNLRELFFSNQTDRTSSNCSCAS
SEFVGTPSPSVVGSDLDVGS----------LHGQRSDVL--DDRELLLLTG-TCSEL-GE
GQWFRRS--CLGPDGTEPSEIGLVSSEHDEASDRESPGVP-PTSD-AGPEDVCLSAEEVR
LSTQVTSTP--------VTAGAAGLQREIQEGTYSGSCYHRDGLQ-----LSIQFEVKRV
ELQGSAPLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSAHSM-SELPGSSLGEMF--KA
KPWFEESPRAVELEGLAACEGAFSCK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTVSPLGS-GAFGFV---WTAVDKEEN-KQVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRSRNIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAAIHPPYLVSAELMSLVSGLLQPAPEQRTTLEKLATDPWLTQPVNLAD
YTWEEVCRVNKP-ESGILSTASLE--MG----SRSLSEAA--QELW----GAP--TL---
--------------------------------------

-----------MEDP-GP-PAVDKDGKCLSGSVSVPAPAKGLSAQA-ASDPSKPL-SAQR
HLSRKDGLSRLCQSRMTLS-EDRWSSYCLSSLAAQNICTSRLR-CPTEPEDGDLA-APLG
SASCCSLLRGLPLGCSVHLLPAPVSNPN

PF00989 // ENSGT00760000119045_0_Domain_0 (149, 246)

KAIFTVDAKTTEILVVNDKACGLLGYSSHDLI
GQKLVQFFLQPDSEVAEALSEEHVEADGYATVVFGTVVDIVSRSGEKTPVSVWMKRVQQE
RGLCCVVVLEPVERISAWVAFQSEGTITSCDDLFAHL----------------HGFSSGE
DVVGQHIIDLIPSLQVPPPGQPVPENLEIQRSVGRARDGTTFPLSLKLKP--KCGGEVA-
-E-------GE--VAPRQGYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LVTLLPDGTIYGINHSFALMLFGYGRTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1349)

IPAFYHYMDLACD-SSLQQPDLTSCPDVGSENGCGEMSSDP-CQY------
------PKVGL------VLASDHALPQD------E-TLKLGGS--QE-VSGGMQMEL-ET
GRC--LPAA---------R--SLQPSP--------------------GADSVPEWHSL--
-----TQDERSLATDQQ----------------------------------------S--
----------IPEGHVPAQEKQSLSENQQDVSEESPPPHGEWGL----------------
--PEDLQDSEEGSPAAHSA-------------------WSLLTDQ----------QVIAS
GRAELV-AAQTPM---------QGLLGESR----SGSVDTKSF--VSCEDAGPLVPAEDR
SSGFRMWGLH--QEAQRALTGASSAS------PQANATIPKPHGAGQPAGGGLL-TCPHY
RSEWLLQQPNPDLAPSPP---GVACVSFGTPTLDEPGPGGRAD-HEEL---------QVC
LVKEQLSRLSFEGAWGI---SCLEPVLTGDWPYSAPLS--CDLGGRDLHGSHL--GGSPA
CYALA--TD-LP----SVPEAAEA---WEA-AMNSCSWSLRELLLRDEMDGTSSNCSCAT
SELEGTPSPSAVHSDFDVDV----------LHRQRPDGL--GDRERFLLTG-TYFDL-GE
GGGPHES--CPEHRPTEPPELYL-SPERCEASDTESPDRGLPTMD-TSLEDAHPSAEDPR
PDAWVTSTP--------VTPGAASLCLEIQEGTYSGSCYHRDGLR-----LSIHFEVKRV
ELQGPSSLFCCWLVKDLLHSHR-DSATRTRLLLASLASSTHSM-PEPPGPSLGEVL--RA
KTRPEEAPLPVELEGLAACEGEYSHKYS

PF00069 // ENSGT00760000119045_0_Domain_3 (1349, 1612)

TLCPLGS-GAFGFV---WTAIHKDRN-KEVVV
KFIKKEKVLEECWIEDPKLGKVTLEIAILSSVEHSNIIKVVDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASYIFRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFHTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFQ
ENPFCEVEETVQATIHPPYLVSQELTSLVCGLLQPAPEQRTTLEKLMTDPWVTQPVNLAE
YTWEEVYRTNKP-EGSLLSTGSLELRTG----SRSLSEAAGDRRLH----GPPGPAEAPS
GQCCSGPEDPSPLVS-----------------------

------------------------------------------------------------
------------------------SSYCLSSLAAQNICTSKLH-CPLTPEYADRP-GSCS
SASCCSLLRGFSAGWPTALLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 237)

AVFTVDAKTTEILVANDKACSLLGYSSHDLI
GQRLTQFFLKSDSHVLEALSEEHVEADGRVAVVSGTVVDIVSHSGEKIAVSVWMKKVQQE
HRLCCVVVLEPVERVSAWVSFQNDXXXXXXXXXXXXXXX----------------XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXSLRLQRSVGRAQDGTTFPLSLKLRSKV--PGE---
---------GL--AAPEGGYSASIWVFCTISGLITLQPDGTIYGVNHSFALMLFGYGKAE
LLGKNITFLIPGFYQYMDLACD-SSVRLPDLAKCLELSSDGGPRETHSDP-WPAWDPASK
AQ---GPRVDV------P-PADYVLPQD------E-PLRLRDG--QA-SSPEAKDPL-DS
GGQ--CLPA---------L--LPRSPT------------------------VPGGSPP--
------------------------------------------------------------
------------------------------------------------------------
---------------P-------------------PCDESSPKDL----------QTPAV
GREAEA-GVEGPK---------ETLLGESG----PDPADINPL--TSCDSSETMLAAEQW
SGDVQACGPR--QKALVNV-------------------PGEHHAAGQPAGGTIPTHHCSF
LSEWALRQPS------PS---GMASVSPGTPVQDELWLGLQND-REEL---------QTS
LIKERLSH-------------------LEHPTFPLPLSH-CRLGGWDAHS-RA--DSSSA
RYTLA--TD-LP----GVLDQVHS-----------SSWDLREGFFGAQMDRTSLACSCAA
SEPLASPCPSAVGSDLGVGG----------LQVQ--DVL--EDRELLLLSG-TCFRL-GE
GRQFRDR------CRPEPSGVSAVSPEPCKANDSESASSLLPASI-ARPEDAHRAAETPS
LSAQVTSTP--------VTPGAACLGRQIQEGTYSGSCYHRDGMQ-----LSIQFQVKRV
ELQGSATLFCCWLVKDLLHSRQ-DSATRTRLLLASSHSSTHSV-PELLGSSRGEVL--RS
KPWFEDSPRSVSLEGLAACEGEYAHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1580)

YSTLSPLGS-GAFGFV---WTAVSREHN-KEVVV
KFIKKEKVLEDCWVEDPKLGRVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDHHPSLDEPLASYIFRQVSV--GKLVSAVGYLRSQSVIHRDIKDENIVIAEDX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAAINPPYLVSQ-------------------------------------
------------------------------------------------------------
--------------------------------------

-----------MEDR-G-VTAFEEDQRCLSQSLPLPVPTDGPAAQT-PVEPSKSFSSAHR
QLGRRNGLSRLCQSRMTLS-EDRWSSYCLSSLAAQNICTSKVH-CPAAPEHTDPA-GPQG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACSLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHVEADGHAAVVFGTVVDIVSRGGEKIPVSVWMKKVRQE
HRLCCVVVLEPVERVSTWVAFQSDGTITSCDSRFAHL----------------HGFLSGE
DVAGQRVTDLIPSVQLPPSGQHIPKNLRIQRSVGRARDGTTFPLSLKLKS--EPSSEEA-
-TT------GE--AAPLGDYWASVWVFRTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKSE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYGYMDLAYD-SSLQLPDLASCLDASDESGCGETTLDP-WQGQGPAEG
SQ---DPRINV------VLAGGHILPQD------E-ARKLVES--ED-IFTGTQTEP-GA
GGR--LPSC---------L--SPQPAP--------------------GVDSVTEGSPP--
-----AHGEQVLPGDQH-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ATAS
GREEPA-AVETPG---------RGLPGGSR----PEPVDAKPS--ASCEDSEAPVPAEDG
GSGAGLGGLC--QQSQRELTGV---SGSDFW---AGVTMAQCQAKGQLAVGSLPMHCPCY
RSEQGLLWRSQDSARSPS---GVAGISLGTPTLDEPWLGVEND-REEL---------QTC
LIKEQLSELSLAGALDA---PHTELVPTEWPAFTAPVLA-CDPGGRDL-SGCT--GSSSA
CYALA--TD-LP----RGLEEVEA---QEA-DVNSFSWNLKELFSSDQTDQTSSNCSCAT
SELGGTPSSSAVGSDPDVGG----------LQEQGSCIL--DDRELLLLTG-TCVDL-GR
GRGFRES--CLGRDPIEPSEVCPVSSEHYAASDSGSPGRIPSTLD-AGPENACPSAEEPT
LDVQATSTPV--------APGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPSPLFCCWLVKALLHSHR-DSAARTCLLLASLPGSTHSTAAELTGPSLGDVL--RA
RPWFEDPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEQN-KEVVV
KFIKKEKVLEDCWIEDPNLGKVPLEIAILSRVEHANIIKVLDVFQNHGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKGVIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSTELMSLVSGLLQPVPEKRTTLEKLVMDPWVTQPVNLAE
YTWEEVCRVNKP-ESGVLSTASLE--MG----SRSLSEMAQAQELC----GGPTPSEAPE
GQSCLLTS------------------------------

-----------------------MLLR------FLPGDMEEPVKRSSASEMNRSFPCINK
CHGRKNGLSKLCRSKTTLS-EERWSSYCLSSLTAQNICRGKLSGCRTRLEHSSLS-GSAY
STPCCSFLNGLATGSSGLSLPTPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 242)

AIFTVDGQTTEILVVNDKACKLLGCSSHDLI
GQKLSTLFSKTDDDVAEALSEERMESDGRAAVTFGIVVDIVGRNNEKIPVSVWMKRIKNE
CGHCCVVVLEPVERISAWVTFQSDGKITSCDLFFAQL----------------YGYTSSE
EVAGLQIADLIPSVQIPPPGKKIPKNLEVQRTVGRAKEGTTFPLSLKLKPRIPEGEPEE-
-TK-------TEPPSDYCFFSASIWVFTTISGLITLLPDGTIYGINNSFALMLFGYERSE
LIGKSITVLIPGFYNYMDPVDD-SSLPLVHLVDCLEMENMSSAEERKKSH-AGDWHLASS
AE---VPEVNI------FPAGDEVRSQS------E-KLKLAGCERGE-LSVRAHAQP-RN
GGG--LPSN---------P--STPPGT-----------------SAAGVDGL--------
---------------------------------------TAKNLPTHGEQPLSENQQSRT
YKEESNTHPSLPDGHFPGKTDTRPS-----------------I---------------LD
SSFKFSVDPNGGSPPIKTQ-PE--------------------------------------
-------DRNVRV---------GGLLPVAR----RESVDSG-------------------
----ETSGHHLGEISKI-------------------------EDLEDPQGYSEKAFTP-D
GKERGIESGTKDSI---GPHSNASNISFGTPTQDEPWQGMMSDSRPER---------QTS
AITEQLVKPNLVWTVGR--SR-F-------ESGADPPSM-CGVRDGGIYGGHA--RLPID
CKTS------------GAASNSEEANGPDI-KVHAICGDLKDLELNVIEGAVS--GSWAT
SVDLRASSSFVGDADTSEEN----------IPSPIFDAP--RRPGSLKLTDASSI-E-SQ
IGQVGDG--CLGDDDEDPSEVCKNFEESEGEGLL-------RN---SDGLSARPKPVQQR
LKTQATSTPVKTSS--EPTAKIPDVKSEILEGSYTGSCYHRDGAR-----LSMQFEVKRV
ELKDPAALFCCWVGKDFFQSHK-EATARTQLFLSSVPSSSQSI-VEVSGFSLGEIM--RT
KRWFDDPPRVMEMEILKACEGEYSEH

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YNTLTPIGS-GAFGFV---WTAKNKEEN-KEVVV
KFIWKNKILEDCWVEDPELGKVTREILILSEIQHPNIIKVLGVFENEGFFQLVMEKHGSG
LDLFTFIDHHPSLDEPLASYMFRQ-------LVSAVAYLRSKNILHRDIKDENIIIAEDF
TIKLIDFGSAAYMERGKLFYTFCGTIEYCSPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEEAMEAVLNPPYYVSEELMNLVSGLLQPIPEQRTTLEKLFQDPWVIQPVNLAN
YTWEEVCPFAKPGSSHLK-GQVLRTATGLGLEQRQDGKMDQSSTPLDQDLGNCFTCQGDT
AQEQVLPRD-----------------------------

-----------MEDR-DP-SDLAEDQRCLSRSPPAQ---EGSIAQA-TSEPNKLLCVAHR
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CSATPEHTDPA-GPLG
STSCCSLLRSLASGCSAPLLSAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 246)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAMVVFGTVVDIVTCSGEKIPVSVWMKRMQQE
HSRCCVVVLEPVERVSAWVNFQSDGTITSCDGLFAHL----------------HGFTSAE
DIVGQYITDWIPSIQLPPPGQPIPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGEAV-
-AD------GM--AVPELGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 436)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYH

ENSGT00760000119045_0_Linker_2_3 (436, 1347)

YMDLAYD-SSVQLPDLANSLSIGSESGPGETSLDA-QQDWDLASG
TQ---DLKVDV------Q-ARDLMLSQD------E-TLKLVGR--QE-VFSGTQTQP-KT
RCL--LSSF---------H--ISQPSL--------------------RVDSISERSPP--
-----VHNEQSLSTDQQ--------------------NTPEESLPTHGGRLLSKNQPD--
----------TPKGNLPVPNEELLSENQENISEESSPTHRGWLL----------------
---KGQRDTKEESPPAHNK-------------------QPLLTDQ----------HISLL
EKEDPV-VAENSR---------QALLGEST----SETMDF-----ASLEASEPLAPAEDK
SSSMGACTLH--QDAQLKLMGVSSPN---PW---ADVAIPEPQTTGQLAGGGLLTHCPHY
RSEWILQKRSEGLAPSSS---GMGCVFLGTPTLDEPWSGVRND-REEL---------QTC
LIKEQLSKSSFAGTLGI---SYMELVPAEHPPFTTPVSF-CDLGGRDLHGSHS--GSSSA
CYALA--TD-LP----GV-EAVEA---QEA-DMSSFSWDLRELFLNDRADQTSSNCSCAT
SELGGTPSPSMVGSDLDVGG----------LHRQSSDIL--GDRELLLLTG-TYSDL-GK
GQQCQES--CAGHDRVEPSEISLVSSECYEASDLESPGCELPTPD-SGPKDMHPSAEEPR
LNAQVTSTP--------VNLGAASLKREIQEGTYSGSCYHRDGLR-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSTHSM-PELCGSSLGEML--RA
KPWFEDPLTSAELEGLAAYEGEYSRK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVEKEKN-KEVVV
KFIKKEKILEDCWIEDPKLGKVTLEIAILSKMEHPNIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDHHPNLDEPLASYIFRQ-------LVSAVRYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPYTVSQELMSLVSGLLQPAPDQRTTLEKLIVDPWVTQPVNLAD
YTWEEVYQI-KP-ENGLLSAASVE--FG----SRSPSEVALVQVLQ----GPPVPGESAV
SQHSLHPEDPSLPVS-----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MASPSLAGSDADLSG----------PHGPGSQVL--DDRELLLLTG-TCLHL-GE
VQ-PRES--CLGRGPAEPSETRVVSSGPYKVSGRENPTCVLPTPG-AGSVEVCPL-EEPR
LNFQVTSTP--------AMPG-APLQHEIQEGTYSGSCYHRDGSW-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLRSHR-DSAARTRLLLASLPSSSHSM-CELSGPSTGEML--RS
KPWFEEPPTALEVEGLAACEGAYSRK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDREEN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVVDVFENQEFFQLVMEKHGSG
LDLFAFIDRHPGLDEPLASYIFRQ-------LVSAVAYLRSKSIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLLGNPYVRGPELEMWSLGVTLYTLIFE
ENPFCELEETMEAVIHPPFLVSEDLMNLVSGLLQPIPEQRTTLEKLVTDPWVTQPVNLAD
YTWDEVCRVNKP-ESGGLSALSLE--ME----SRCAREVA--PEPC----GALCPRGGPC
--------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------SLPSCARSSNRAVLTVSTKTSKILMANDKACRLFEYSSPELI
GMSLSQLIPASSHRVSEALEDELTESDGFSR-VPGEVVEAVRRGGETITLCMWIRRIQNQ
----CLLLLETVQQITATVSFRQDGRILSCDPTCARL----------------YGYMEPE
EVLGQHITDLLPTVNIPLQGREIPQNLRCQRLVGVTRDGANFPLSLNLSEASVDT-----
-------------GSHVEEYCASLSILSSINGLITLRPDGSIRGLNGSFSNSLFGYDRTQ
LLGKNITFLIPGFYHYMRSAGDEPSPLLTPLGETLDTSGSS---DMISSNATKGKLIVNG
SFAVCSTKLTTISCMATHMANDWNILWT------CAKLEFLGT----------HAHRKSI
SVE--EPTD---------I--YFKGPI---------------TLIFEHLWCIIRKEQP--
----------------------------------------IGD-------ILSIF--LCV
FVEK----------------------SSEHDTFHNPLSDGNWLQ--------APACCILQ
TSQT----------PL------------------TRYEFS--LANHCSVFSLYI------
---------E-----------CWLYKYHNNSDQFTEPGNLNCSATLPCLPRFLFRFVHSQ
SQNLTLLH---MHESQAESGTPGKA----RY--GGTAIRTEEQTTGSLVNMTLLVLAVNN
QEMAVSSAPENDYLQS----VPTCCVSPGTPTQDEPWEREKYT-RHDLDLESGITPLTHC
LRTLSLSKSQSEKKEAHQHINSHQVFPTVEKAFSPVLSP-CPSAVGEIHQPPNALGVSPP
ITVQV--TR-LP----GSPSFLSE----------TTSIPLRNV------------CSNA-
-HHHGTLLQAEITHNMNETNAARSTPSANNIPVISSPPL--CHHNPVIKTA-SVIHANNA
GANNTPS--STLHNNLSLSPVSTVSFSEYIMQSTANTSCSPDKNSPTPNLSPCRSVEP--
-------DAVNRLSREESSPIPPSQEGEIREGIFNGSCYHRDGSR-----LFIQFDVQRT
VSAG-SYLFNVWVSKDLLQSQR-DAIARTRLLLSSFASSSQSL-LEQSERSLGELI--RN
SANAGYCTELQDLQIVGACNGQYALK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YQTVSPLGK-GAFGFV---WSACGRDSAKEEVVV
KFIRKDRVLDDCWVQDPELGKVTQEIAILSRVQHPNIIRVVDVFENDTFFQLVMELHGDG
LDLFDFIDSQPSLDEPLASYIFRQ-------LVSAVGYLHNQHILHRDIKDENIIIAPDF
SIKLVDFGSAAHLHQGTLFSTFCGTTEYCAPEVLLGNPY-PGPELEMWSLGVTLYTLIFG
ENPFCEVDEILEAELNPPFNVSQKLQVLISGLLQRDPEIRMTLDELLRDPWVTQPINLAE
YTWEEV------------------------------------------------------
--------------------------------------

-------------------MACSARGRSAGS-----TPGLGPP--SDSEQLSRSY--PWA
GGGGRSRLAGLCRRGASLS-GEKWSSYCLSSLAAHNICASKTGNSRAQWDSSSLS-ISVG
SS-SCSFVHTPALEESSQHFLTAARNPNQ

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 205)

AIFTVDVTTTEILVANDKACRLLGCSSQELI
GQNLSRFISKCNQETWEAVDDEYLETDECTSMVSGTVVDVINCLKEKIPVSVWLRRIRIK
DNQRCVVLLEPVERLSAFVSFRADGGITSCDLLFAHL----------------HGYPTLE
EVVGLHIKDLIPAVQIPLLGKKIPKNLKVQRAVGRSREGNVFPITLKLQVSLLEEDQVAA
QNNGVLQTERE-ISFPDYHYAATVEVFSTISGLITVQSDGTIQCIKDSF

PF13426 // ENSGT00760000119045_0_Domain_2 (410, 434)

ALTLFGYEKKE
LVGKNITFLIPGF

ENSGT00760000119045_0_Linker_2_3 (434, 1347)

YNNMERSDD-CSLPLPPLDDSLGMESECFFEDVSACH-TAGSGCRSK
AN-------LL-SRDEE-------Q------------KL-ERRHREDRLL-PGETK----
----------------QKIGSS------LLSIP--SSP-EVAAILSNREGSIVADGLS--
-----AHCGEPSPETQPDRIRALEH---------------------------------CG
VEEN-------------------------ARSCNPPEMHPAWVSPP--------------
SSASEQ----------------------------------LDLDQNL-KTPLRSGHSAAS
GTSETGNASES-----------SFLLNQLH-VHHQDPKELNCQ-----------------
--QV-SRMPHEMLKDQHST-----------------------VAQGQSSSANVAWLTIFS
SPVDKLDTVSSGVSKPP---SCFPCNSSGTLKINEPQPGTTLGCTQDF---------QSH
VARGQLTKTSFVCDGKH---SSLEHTVAESSLLKDANV--IANGRNSTHDVCS--GNTVG
CTGSA--LG--------AASTFQTMRQTDT-ELNCICSDLKELDLNIGVTGNSGNCLGST
SDFVEVFFSNTVNSAAGT------------MLTPKSGLF--S--AEQLLNGV-AI---KD
GSGCLPSQQHLENPE-QSSKVFIEKPKTLTETVGDNVNRNIL-KSKGNPEEDCQFHGQES
MEIKVTSTPVKQEQ---RPNHAAPFSAEILEGSYSGNCSHRDGSQ-----LSILFEVRRV
ELQDPAVLFCVWVVKDLLQSQK-EAVAKTQLLLSSLASSTQSV-LDLSTHSLGEAI--KS
SSLSENSRRAEELERLRACEGEYATH

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YDTLSLIGK-GSFGFV---WTARSKKNH-QEAVV
KFIWKERVLEDCWVDDPDVGRVTQEIAILLKLQHPNIIKVLDVFENERFFQLVMEKHGSG
LDLFTFIDNQPDLDEPLASYLFRQ-------LVSAVGYLHCRNILHRDIKDENIVIAEDF
TIKLVDFGSAAYLQPGKLFYTFCGTIEYCSPEVLSGKPY-HGPELEMWSLGVTLYTLIFG
ENPFCELEEAMAAVLNFPRLVSKDLMNLIVGLLHPAPEQRTTLAMLVEDPWLKQPVNLGD
YTWEEVYISAGA-ESNGLRNGSVECSRR-----DRPSAPRMESEPC----------LSAS
SCVCAHPPWEGAAAVRCQGWSLGSRCSRSLQQPLPVQH

-----------MEDR-GS-AALEDERRCLSGSLTLPAPMESPAMQG-TSTPSKSFSSAHR
HPSKKHGLSKLCQSRTALS-EDKWNSYCLSSLAAQNICTGKLH-CPGVPELSDAA-GSVG
STSCCSLLRGLPSGLSSPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 204)

AIFTVDAKTTEILVANDKACELLGYSSHDLI
GQKLTQFFLKSDSDVVEALSEEHMDADGCAAVVVGTVVDIVSRSGEKIPVSVWMKRIRQE
HTHCCVVVLEPVERVSAWVSFQCDGTITSCDSLFAHL----------------HGYTSGE
EVAGQRITDLIPSVQIPPPGEHIPKNLRIQRSVGRARDGTTFPLSLKLKF--KPGSNDA-
-EG------GL--PLPAPVYTASVWVFCTISGLVTLLPDGTIYGINHSFALMLFGYGKAE
LLGKNIAFLIPGFYSYMDLACDDSSLPLPDLARCLDVSQDRHSGRMLAEP-WQGWDLSHG
AD---GSSVSV------VLADADALLRD------V-TLAPAGS-QTD-SRVSA--LV-KA
---------------------AGLPRV--------------------RMQEVPMRGAG--
-----RLGESSGPTQRH--------------------AAHRGVFSSR--FLLLKS-----
--------------FL-----MCSSETRLNLRRTRSVL---TPL----------------
--PLPPSGHPTPGPTVITSYI----------------SMSLFFSQKCRRIMVKKATISSA
AKKEKK-KKKPCK---------WIMLYVSC----SKRSYICIV-----------------
-LDVSLYRVTTSENPKPGLLGVF-----RKVSAQVAATVPKPSSTSQPAGAGFSMHCPRC
GTELLARRRV----LSPP---GTTHVLLGRLTLDELWPGGGSD-REEL---------RTC
LIREQLSTPSSPGAVGT---PSAKPLPAEHPTFAAPLSP-CGLGGRDLQGSRS--GSSSA
CYALA--TD-LP----GAPEHTEG---HDT-DAATFSWDLKELFLSERVARASSDCSCAT
LGLTRTPSSLGVGSNLDEGS----------LQREQSGALELGREGLLLLTR-TSSDL-S-
--GFQKG--YLAHSQTGPPEACVLPSLP---------------PE-ASPGHVLPCTEPPE
LGLQTTSTPVRRES--TPPPRAAGPRREIQEGTYSGSCYHRDGSR-----LSVQFEVRRV
ELRAAATLFCCWLVKDLLHSHR-DAAARNRLLLASLPDSTHSM-AELPGPSLGEVL--GA
KPWFEEPPKVSELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEEN-KEVVV
KFIKKEKVLEDCWVEDPKLGKVTLEIAILLWVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFTFIDRHPNLDEPLASYIFRQ-------LVSAVGYLRSKGVIHRDIKDENIVIAENF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLLGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAVLNPPYEVSKELMSLVSGLLHPVPEERTTLEKLVEDPWVTQPVNLAD
YTWEEVCRVSRP-ESGVLASMSTE--TE----RRSPRDVRRGPG----------------
--------------------------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSANR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-RPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKHLKIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 394)

PLSLKLKS--QPNSEEA-
-TT------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVSDESGCGEKTLDP-WQGQDPAEG
SQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPA-AVECPG---------QDLLGESR----SEPVDVKPF--AACEGSAAPVPAEDG
GSNAGVCGLC--QEARLERMGVSGPSGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTPSSLAVGSDPDVAS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVGLVSSEHYVASDGESPGHIPSVLD-AGPEDTCPSAEEPR
VNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCFHPGDPHVLTS-----------------------

-----------MEDR-GP-TVFAEDWRCLSECPPVQ---ESPAAQA-TVEPSKPLSIAHR
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CAAAPEYADPTAGPLG
STSCCSLLRGLASGCSGPLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQD
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVIDLIPSMQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKSNFKPSGKAE-
-TD------SE--VASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYHYMDLAYD-NSVQLPDLVSCLDIGSKSGPGEMSSDA-QQDWELASG
AQ---GPRIDV------VLARGHMPSLD------E-TLKLVGG---Q-VSPRTQTRL-ET
GCK--ILPS---------S--ASQPSL--------------------GVDSNPED-----
-------GEHLLLTDQQ--------------------SIPKRNLPARGGQLLSQNQPY--
----------TSEIILPVLKEHLLSEIQENISEESPLTHRKWL-----------------
--SKAQQNTTKGSLPIHDE-------------------QLLLASQ----------HIQVL
GKENPS-AAESYR---------EGLLEESK----SKPVDAKLFA--SCQDSEPLVLVKDR
SSSVDMCNLQ--QEAQLELMGVSSPSSPNPW---ADATMPEPHTTGQIAGG-SLTYCPQH
RSEWVSQQRGQDSAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSCGGTLGI---SCVELIPAEHPPFTAPVSF-CDLGGRDLHASRS--GSSSA
CYALA--TD-LP----GVLEAVEA---QEA-DVNSYSWNLKELFVKDQTDRTPSHCSCTT
SELSETPSLSVVGSDLDVGS----------LHRQTSDIL--VDREMLLLTG-TYFDL-GE
GQRFQEM--GAGHDQTELSNISLVSSEHYETSDIESPGCDPPLPD-PGPNDMCLSAEKPS
LSAQITSTP--------VAHGATSLQQEIQEGIYSGNCYHRDGLR-----LSIQFEVKRV
ELQGSATLFCCWLVKDLFHSHR-DSATRTRLFLASLPSSTHSM-PELSGSSFGEVL--RA
KPWFEESPIPAELEGLAACEGEYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTISPLGS-GAFGFV---WTAVEKECN-KEVVV
KFIKKEKVLEDCWIEDPKLGRVTLEIAILSKVDHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDHHPCLDEPLASYIFRQ-------LVSAVGYLRSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLIGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIMDPWVTQPVNLAN
YTWEEVCRTNQP-ESGLLSAASLE--LG----SRSPSEVAQTEGLC----GPPAPRETRG
DQHCLHLEDPSLPVS-----------------------

-----------MEDG-GS-TASVEDHQGPGGSPSLPDPPEGPTAPA-ALEPGKSGSSAHR
HVSRRTGLSKLCQSRMALS-EERWSSYCLSSLAAQNICTSKLH-CSAAPGQADLT-GSLG
STSCCSLLRALSSGWSTPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 240)

AVFTVDAKTTEILVANDRACRLLGHSSHDLI
GQKLTQFFLKPDPDVVQALSEEHVEADGHAAVAFGTVVDVVSRGGERIPVSVWMKRVKQE
RSLCCVVVLEPVERVSAWVAFRSDGTVTSCDGLFAHL----------------HGFASGE
EVVGQHITDLIPSLQLPPPGEHVPTHLKIQRSVGRARDGATFPVSLKLKS--QPCSKEA-
-AD------GE--AAPSEGYSASVWVFSTISGLITLLPDGTIYGINHSFALMLFGYGRAE
LLGKNITFLIPGFYHQMDLAYD-SSLPLRDLASCLDAGSRSGPGGSISEG-NYDCVASDG
IRCVSGL------------RCECVMSDR------R------------------ESPC-QM
GCL--SCLS---------R--SAGAFP------------------VSRRFSVVRGLPSRA
TPAPVSKGGHRDPKASR------EPGHM----PHGPRGLPAGAARS--------------
---------------------------------QVSPLSRSLILKNHFETELLKKNGGSR
SPPECPRDVPEGGPSA-------------------RSGPSSPEGQ----------QRSVS
EQEQPA-TAEHLS---------RDLQRGSQ----FELGDTKLS--ASQEDSEAAIPGADR
SSGDETHGPC--QEAWAERGSASDSD---QG---PDVATAVSHTEGCLAGQG-------P
QGEQSALPGSPCLAASPP---GTLQLLFSTPPLDEPWLEARQD-REEL---------HTC
LIKEQLSASSRAGPWGV---SYAELVLMGQPPLSAPASL-LDLRATEH---------GAV
CLALA--TD-LP----GALEAVEV---PEA-SENSFSWNLKELVFRDWTDRTSSNCSCAT
SELGGTPSPSLVGSDADVGA----------LHRQRSDVL--DDRELLLLTG-TCVDL-CG
GRRFRES--RLGLEETEPSQTCLVSSEHQDVNGCDSPSRVLPVLA-AGPEDECPL-EAPG
LSLHVTSTPVRAEGPGPAPLRAADLQPGIPCGISM----YRAG-----WHLCVQFEVRRV
ELQGPATLFCCWLVKDL---------LRTHLLLASLPSSAHST-CELPAASLGEVL--GT
RPWFEEPPKAVEPEGLAACEGAYSLK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPIGS-GAFGFV---WTAVDKEAN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILCKVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASYIFRQ-------LVAAVVYLRSESILHRDIKDENIVIAEDF
SIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSMGVTLYTLIFE
ENPFCELEETMEAAINPPYLVSEDLMNLMSGLLQPVPEQRTTLEELVTDPWVTQPVNLAD
YTWEEVCRLNKS-DSRALSTVGLEL-----------DAAARAPEPH----RPSCSRAGPR
APAD----------------------------------

-----------MEDR-GLT-AFEEDQRCFSQSLPLPVPAEGPAAQT-TAKPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEPTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
HRLCCVVVLEPVERVSTWVAFQSDGIITSCDSLFAHL----------------HGYVSGE
DMAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPNSEEA-
-TT------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLVSCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLADGHIVPQD------E-TQKLVES--QD-IFTGTQTDL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEAQLERMGVSGPSGSDLW---AGAATAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTVDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTECPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGPEAVEA---QEV-DMNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTRSSLAVGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLMSSEHYAASNRESPGHVPSVLD-AGPEDVCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLYSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--SA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRVLTS-----------------------

-------------------MAFEDDRRCLSGSLPWPVRAEGT------PVPSKCPSPACW
PLGRKNGLAKLCRSRVALS-GDRWSSYCLSSLAAPAVCPGRAP-CPWPPDCPDPA-GSPG
SASCSSLLHGLSCGP-----AAPVCSPH

PF00989 // ENSGT00760000119045_0_Domain_0 (149, 249)

KAVFTVDAETTEVLVANDRACELLGYSSHDLI
GRRLTQFFVKFGSDVAEALGEEHVEADRQASELSGVVVDVVSRSGQKIPVSVWMKRMVQG
RSRCCVVVLEPVERVSAHVTFRSNGTVTSCDSLFAHL----------------HGYASGE
EVAGQQITDLIPSVQVPPPGGHIPKAMPIRRAPRRAYLRQRSPKGLGLGCWPCAGDWAS-
-GTGPGSGSGLCTAAVRVHAAALAWA-------LHLLPGRPIWRSGHTVGGRA--GAAQL
ARGRNITFLIPGFYGYMDLAYD-GSLPLPDSASGLDLGPQRGTGL-AADP-RPGWSLGSG
AE---DPSTDS------LPAGENVPPRG------DETPVLAES-RGQ-GFVRARAQC-AA
GGR---PPS---------L--CAQPAP--------------------GVDNATRGGPP--
-----GRS--PQPGEQQDATEGAPPAHSMQLG--EQQDATEGAPPAHGAQLG--ERQD--
----------ATEGAPPAHGAQLG--ERQDATEEAPPAHGVQSEKQQDATEGAP--LTLG
AQLGEQQDTTEGGPPVHSTQPGER-------------------------------QDAAL
VKQEPA-A-ESPK---------Q-VPGGRG----SEPGTTSPP--VFLEDPESPAGAEHE
GSRAQACGTY--QQARPELGP------------LAGAPVPGPRAADLPTGVGCLAPRPGH
ERDQSALRGG----------GASGAAWFRTPALDEPWLEWGSD-REEL---------QTC
LIKEQLGAGGA----GT--GVPYAALPAEHASCAAPLLR-CELRGRDLRSGHS--GSSSA
CYAFA--TD-LP----GVLEGPEA---EDA-NVNTLSWDLGGLLSGARTHRGPSNCSCAT
SDPDGTPS-SLATSDLDMGS----------LQEQGGPR---GRAGLLLLTGSASVDL-GE
AGTFRQG--CPGHDQAAPAMPA-----KPGVGGGEGGGHGVPSLPGAVPAGVLPLAEQPK
GSLQLTSTPVRGFS--TPAPGAAGPRHEIQEGTYTGSCYHRDGSR-----LSMQFQVKRV
QLHSSVTLFCCWLVKDLLRSRC-ASATRTRLLLASLPGSTHSM-SELSGPSLGEVL--RT
RTWLEEPPTVGELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEEN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVVDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLEEPLASYIFRQ-------LVSAVVYLRSKSIVHRDIKDENIVIAEDF
TIKLIDFGSAAYLESGKLFYTFCGTIEYCAPEVLLGNPY-EGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAALSPPRPASEELMSLLSGLLHPVPEQRTTLEKLVADPWVTQPVDLAD
YTWDQVCHMSKS-EGGALPTLSLD--SE----RRSPREAARGQEPC----WAPCPEEGS-
--------------------------------------

-----------MEDG-GP-PGFAEDWRCLSGSPPAQ---EGPATQA-SSELSKSLSIAHR
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLAAQNICTSKLH-CSAASEHADPAAGPLG
STSCCSLLRGLASGCSAPLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDKACSLLGYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGHAAVVFGTVVDVVSRSGEKIPVSVWIKRLQQE
RGLCCVVVLEPVERVSAWVAFQSDGTITSCDSLFAHL----------------HGFTSAK
DVVGQCVTDLIPSMQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGKTV-
-AD------SE--AASEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 437)

LITLLPDGTIYGVNHSFALRLFGYGKTE
LLGKNITFLIPGFYHY

ENSGT00760000119045_0_Linker_2_3 (437, 1347)

MDPAYD-SSVQLPDLVDCLDLGSKSEPGEMSANA-QQDWELASG
AQ---DPRVDV------VLARDPVLSQE------E-TLKVVGG---Q-VSLRTQTPL-ET
GCQ--ILPS---------F--SSQSSL--------------------GVDSNPVY-----
-------GEHSLPTDHQ--------------------SIPKRNLLAHGGQLLSQNQPD--
----------TPEVSPPVLNEHLLSEIQKNISEESPLTHRKWLL----------------
--PKAQQDTTKGSLPIHDE-------------------QLLPAGQ----------HVNVL
GKENPS-SAESYR---------KGLLEESR----SKPKDAKLFA--SREDSEPLVPAKDR
SSSVDVCSLH--QEAQLELMGVSSPSSPKPW---ADATMPEPHATGQLAGGGFLTHCPQY
RSEWLLQQRGQDLAPSPS---GMACVLLGTPTLDEPWSGVRND-REEL---------QTC
LIKEQLSKSSFGGTLGI---SCVELVPAEHPPFTAPVSF-CDLGGRDLHASHL--GSSSA
CYALA--TD-LP----GVLEAVET---QET-DVNSYSWNLRELFLNDQTDRTPSHCSCTT
SELSETPSPSVVGSDLDVGV----------LHRQRSDIL--GDREMLLLTG-TYFDL-GE
GRQLQEM--GAGHDRAELYDISLVSSEHCETSDVESPGCGPPIPD-PGSDGMCLSTEKPR
LSAQVTSTP--------VAPGVSSLQPEIQEGIYSGSCYHRDGLR-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLHSHR-DSATRTRLLLASLPSSTHSM-PDLSGSSFGEVL--RA
KPWFEESPIPAELEGLAACEGEYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTISPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWVEDPKLGKVTLEIAILSKVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVGYLRSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPCLVSQELRNLLSGLLHPSPEQRTTLEKLIIDPWVTQPVNLAN
YTWEEVCRTNQP-GSGLLSAASLE--LG----SRNPSEVAHTKDFS----RPPAPREAPG
DQHGLHLEDPSLPVS-----------------------

----------------------------------------GPSTQA-ASEPSKPL-STRR
HLSRKDGLSKLCQSRIALS-EDRWSSYCLSSLVAQNICTGRVR-CPTAPEHVDPA-APLG
SASCCSLLRGLSSGCSMPLLPGPVYNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 246)

AIFTVDAKTTEILVANDKACGLLGYSSHDLI
GQKLVQFFVQPDSEVAEALSEEHVEADGHAAVVFGTVADIVSRSGDKIPVSVWMKRVRQE
RGLCC

ENSGT00760000119045_0_Linker_0_1 (246, 263)

VVVLEPVERISAWVAFQ

PF13426 // ENSGT00760000119045_0_Domain_1 (263, 355)

GEGTITSCDDLFAHL----------------HGFSSGE
DVVGQHITDLIPSLRLPSPGQPVPENLKIQRSVGRAKDGTTFPLSLKLKP--KQDGEAA-
-E-------GE--AVPEQGYWASVWVFCTISGLITLLPDGTIYGINHNFALMLFGYGKTE
LLGKVGLVAAT-------------------------------------------------
------------------------------------------------------------
-----------------------PLST--------------------PSSYVLDGYPL--
-----AQDKRSLPTDQQ----------------------------------------S--
----------TPEEHVLAHEKQSPSENQQDVSEESPPTHEEWLL----------------
--RKDPQDSQEGSPPALSV-------------------RTLPRDQ----------QDTAL
GSVGPV-VAQSSP---------QDLLGESG----SEPADTKPF--VSCEEPNPPVPPEDK
CSNVGMGSLH--QEAQWALTA---------------ASRPEPHAAGQPAGGDLLTYCPAY
RSEWLP---------WPPGHSGVACVSFGTPTLDEPWPGRRAS-HEEL---------QVC
LVKEQLSRLSFEGV------SRLESVPTEHRPYTASLS--SSLEGRDLCGSHL--GSSSA
CYALA--TD-LP----DALELVEA---REA-AMNSYSWNLRELLLSDDTDGTSSNCSCTT
SEPGGSPSPSAVSSDFNVHT----------LHKQRPGAF--GDRERLLLTG-TYFNL-GE
GQGSQES--NLEHDPTELPVMDLA-SERYETSNSQS--SELPAMD-ASQEDARASAEDPK
LSAWVTSTP--------VKPGAASLCREIQEGTYSGYCYHRDGLW-----LSICFEVKLV
ELQGPVSLFCCWLVKDLLHSHR-SSATRTRLLLASLPSSTHSM-PDPSGRGLGEVL--RT
KPWAEEAPTPMELEGLAACEGEYSRKYITLRPLGS-GAFGFV---WIAMDKEQN-KEVV-
----------------------------------------

PF00069 // ENSGT00760000119045_0_Domain_3 (1421, 1612)

LDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASHIFRQ-------LLSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEATIHPPYLVSQELMSLLSGLLHPDPRQRTTLEKLVTDPWVTQPVNLAQ
YTWEEVCRISKP-ESGLLSTASLQHRTG----SRSLSEAG--SEFQ----AHPAPEEAPS
SQHCLGPEDPSPLAS-----------------------

-----------MEDR-GLTKAFEEDQRCFSQSLPLPVPADGPAAQT-TAKPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEPTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
HRLCCVVVLEPVERVSTWVAFQSDGIITSCDSLFAHL----------------HGYVSGE
DMAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPNSEEA-
-TT------SE--AAPARGYCASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLADGHIVPQD------E-TQKLVES--QD-IFTRTQTDL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEAQLERMGVSGPSGSDLW---AGAAMAKPQAKGQLVGGSVLMHCPCY
GSEWGLWWQRQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLVGALDV---PHAELVPTECPAVPAPVLS-CDLGSRDLHGGFT--GSSSA
CYALA--TD-LP----GGPEAVEA---QEV-DTNSFSWNLKELFFSDQTDQTSSSCSCAT
SELRGTRSSLAVGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLMSSEHYAASNGESPGHVPSVLD-AGPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTSLFCCWLVKDLLHSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVMSAASLE--MG----NRSPSEVAQAQELC----GGPVPGKAPN
GQGCLHPGDPRVLTS-----------------------

MEAWQLASILPMEDR-GLM-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAELSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 246)

AIFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSHVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
HRLCCVVVLEPVERVSTWVAFQSDGTITSCDSLFAHL----------------HGYMSGE
DMAGQHITDLIPSVQLPPSGQHIPENLKIQRSVGRARDGTTFPLSLKLKS--QPNSEEA-
-TT------SE--EAPVRGYWASIWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFLIPGFYSYMDLAYD-SSLPLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-ET
GSQ--LFSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GRDEPV-AIESPR---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLEQMGVSGPGSSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSCAP
SELRGTPSSLAVGSDPDVAS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRQFRES--CLEHDPTEPLEVCLVSSEHYVASDGESPGHVPSVLD-AGPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQKYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1607)

SPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELY----GGPVPGEAPD
GQGCLHPGDPRVLTS-----------------------

---------------------------------------------------SRSF--SWG
NKSRKSRVSGLCQLGASLPGGEKWSSYCLPSLTARNICSSKIGNSWARWDPASLS-ASIG
SSASCSFLHTPAVEESSQHLPAAARNP

PF00989 // ENSGT00760000119045_0_Domain_0 (148, 194)

NQAIFTVDASTTEILVANDRACKLLGCSSQELI
GQKLSHLISKSDQEAWEAVGEEYPETSECSSVVSGAVVDVIGHLSEKIPVTVWLRQIQSK
DTQRCVVVLEPVERLSACVSFTVDGKITSCDLLYAHL----------------HGYPTLE
AVVGLHIKDLIPSVQIPPLGKKIPKNLRIQRAAGRSREGTMFPLSVKLEVSHLEEEQAAV
QKDEIAQTEG---SLPGYQYSATVVVFSTISGLITVQSDGIICGITDSFALMLFGYEKKD
LLGKNITFLIPGFYNNMGRSSG-CSLPLPPLDDSTGTEEMHMCAETNAPH-WNKEMMPKP
GV-------ES-SFLAASLA--HLLSRD------E-EQKLEQLHKDDRLIHDENKQ--KN
GTSFFSPPSPPEAASTPTSSKYLLPILRKKALPSNCRLWMMVKDLVFALRTALLQMGS--
-----QPTREPFPKSWLDTIRAAAQ---------------------------------YR
TVET-------------------------SGSNNSQKMFSARLPLT--------------
SPDSEQ----------------------------------WDLGQNS-ETAESSSHSAVI
SCI--------------------------C-SRLEDPHA---------------------
------------------------------------------------------------
--------SSCDPLKLP---AGVTCNSPGTPTVDEPWPGAALNCRQDL---------KSH
MVPGQVSKTNSTCDAKH---SSLEHIVVHNCLLNDPSF--FASERNTVCGVCS--GNKTG
CSASA--PG--------AATSSEDVK--ES-ELNCICSGLELLGLNTGVKGNSDNSSGVT
AALVGGCCSDAVDSN--M------------IIETNSTFS--THQGKQLLSGV-AT---EA
DCGWLASRRHLQNS-----EAFPEKPETFAETVGHNSNRNPL-KSKSRPEEHCQLLGLQN
MEIKITSTPVKQED---RLNPAAPLSWEILEGSYVGNCCHKDGSQ-----FSIHFEVKCA
ELQDPTLLFCVWVVKDISQSQK-EAVAKTQRLLASLTNSSQSV-ADLSTKSLGEAI--RS
TSLFDNSPRAEDLEGLRACEGEYAKNYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1607)

NLIGK-GSFGFV---WTARSKKDH-QEVVV
KFIWKERVLEDCWVDDPDLGRVTQEIAILQKLQHPSIIKVLDVFENECFFQLVMEKHGSG
LDLFTFIDNQPNLDEPLASYIFRQ-------LVSAVGYLHCRNILHRDIKDENIVIAEDF
TIKLVDFGSAAYLEPGKLFYTFCGTIEYCSPEVLSGKPY-HGPELEMWSLGITLYTLVLG
ENPFCELEEALAAVLSPPHPVSEGLMDLMAGLLRPVPEQRTTLAMLAEHPWLRQPVNLAD
YTWEEVFASAEP-AGTSV------------------------------------------
--------------------------------------

---------------------------------------ESPAART-ASEPSASLSSAHR
HLSRRNGLSKLCQSRMGLS-EDRWNTYCLSSLAAQNICTSKLH-CLVAPEQTELA-GSLG
SMSCCSLLRGLSLGWSTPLLPTPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 209)

AVFTVDARTTEILVANDKACQLLGHSSHDLI
GQKLTQFFLKPDSDVVKALSEEHVEADGHAAVVFGTVVDVVSRSGEKIPVSVWMKKVKQD
HSLCCVVVLEPVERVSAWVAFQSDGTVTSCDSLFALL----------------HGYASGE
EVLGQHITDLIPSVQLPPPGEPVPQNLKIQRSVGRARDGTTFPLSLKLKS--ESSSEMV-
-ED------SS--AVSEWGYSASVWVFSTISGLITLLPDGTIYGINHSFALMLFGYGKTE
LLGKNITFLIPSFFHYMGLARD-SSLPLPNLADCLDIGNQSGPGKTSVGP-QQGRNLAGT
AT---DPRANS------ALVGDHVLPRG------E-TLEPVGS--QE-DFAGTQAQA-DA
GGR--LPSS---------L--LGLPTP--------------------GVDSIPESRPP--
-----AQE-WSSPEDQL-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------STLL
EKEEPA-APESLR---------QDLVGASG----SDPVDTRMS--ASRE------GSEDR
SRHTEMCGLY------QEWTSLSNARNSNRR---AESIKPKPHATGQPAGEGPLMPCPGY
GGEHSTPSGS------PP---GTAQLPFSTPTLDEPWVAVEND-REEL---------QTC
LIKEQLSKLSLMGPRGG---SYTELAPAEHPRGSAPVSL-CGPGSRGRCR-RA--GSSSA
YYALA--TD-LP----GVLGAVQA---QEA-DGNSFSWNLKELFFNERTDRTSSSCSCTA
SELAGSPSASLAGSDVDVSG----------LHGRRSDVL--DDRELLLLTG-TYFDL-GE
ARQFHES--RLGPDQAEPSETGLVSSEHYEVSGRESPACVLPTSG-AGPVDACPS-EEPR
LSFQVTSTPVRGDS--LVTPGPVRVQQEIQEGTYAGSCYHRDGAQ-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLHSHQ-DSATRTRLLLASLPSSSHSM-LELSGSSVGEML--RS
KPWFEEPPKAVELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFFCSRWSSVAVSNL-REVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVDHANIIKVLDVFENQAFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASYIFRQ-------LVSAVGYLRSQSIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGRLFHTFCGTIEYCAPEVLMGNPY-KGPELEMWSLGVTLYTLIFE
ENPFCELEETMEAMIHPPYLVSEDLMELMSGLLQPVPEQRTTLEKLVADPWVTQPVNLAN
YTWDEVCRVNKP-ESGALSGVSLE--TE----SRCTREVAWALEPC----GALCPRGGP-
--------------------------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVSAEGPAAQT-TAEPSRSFSSAHR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPS-EPRG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 240)

IFTVDAKTTEILVANDKACGLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQE
RRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPSSEEA-
-TT------GE--AAPVSGYRASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVGNESGCGERTLDP-WQGQDPAEG
GQ---DPRINV------VLAGGHVVPRD------E-IRKLMES--QD-IFTGTQTEL-IA
GGQ--LLSC---------L--SPQPAP--------------------GVDNVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ITAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSEAPVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSGSDLW---AGAAVAKPQAKGQLAGGSLLMHCPCY
GSEWGLWWRSQDLAPSPS---GMAGLSFGTPTLDEPWLGVEND-REEL---------QTC
LIKEQLSQLSLAGALDV---PHAELVPTECQAVTAPVSS-CDLGGRDLCGGCT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSNCSCAT
SELRETPSSLAVGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMRGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSAARTRLFLASLPGSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTMSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLAD
YTWEEVFRVNKP-ESGVLSAASLE--MG----NRSLSDVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRLLTS-----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------LSEETR
PSVQVTSTP--------VVPGAASLQQEIQEGTYSGSCYHRDGLR-----LSIQFEVRRV
ELHASASLFCCWLVKDLLHSHR-DSDTRTRLLLASLPSSTHSL-AELPGSGLGEML--RT
KSWFEEPPRAVELEGLAACEGEYCHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTVSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSKVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRSKNIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAEIHPPYLVSEELISLVSGLLQPAPEQRTTLDKLVIDPWVIQPVNLAN
YTWEEVCPVNKP-GERLLGILPSL--SD----FT--------------------------
--------------------------------------

-----------MEDP-GP-PAVDKDGKCLSGSVSVPAPAKGLSAQA-ASDPSKPL-SAQR
HLSRKDGLSRLCQSRMTLS-EDRWSSYCLSSLAAQNICTSRLR-CPTEPEDGDLA-APLG
SASCCSLLRGLPLGCSVHLLPAPVSNPN

PF00989 // ENSGT00760000119045_0_Domain_0 (149, 246)

KAIFTVDAKTTEILVVNDKACGLLGYSSHDLI
GQKLVQFFLQPDSEVAEALSEEHVEADGYATVVFGTVVDIVSRSGEKTPVSVWMKRVQQE
RGLCCVVVLEPVERISAWVAFQSEGTITSCDDLFAHL----------------HGFSSGE
DVVGQHIIDLIPSLQVPPPGQPVPEVGPALPAPNPTT-GLS-CSGMCLRC--DCGMEPD-
-A---LSATCS--CSPSLTWSREAWLI--------------------------TGCRLAW
ASFGNITFLIPAFYHYMDLACD-SSLQQPDLTSCPDVGSENGCGEMSSDP-CHWQLCSEA
----CHPKVGL------VLASDHALPQD------E-TLKLGGS--QE-VSGGMQMEL-ET
GRC--LPAA---------R--SLQ------------------------ADSVPEWHSL--
-----TQDERSLATDQQ----------------------------------------S--
----------IPEGHVPAQEKQSLSENQQDVSEESPPPHGEWGL----------------
--PEDLQDSEEGSPAAHSA-------------------WSLLTDQ----------QVIAS
GRAELV-AAQTPM---------QGLLGESR----SGSVDTKSF--VSCEDAGPLVPAEDR
SSGFRMWGLH--QEAQRALTGASSAS------PQANATIPKPHGAGQPAGGGLL-TCPHY
RSEWLLQQPNPDLAPSPP---GVACVSFGTPTLDEPGPGGRAD-HEEL---------QVC
LVKEQLSRLSFEGAWGI---SCLEPVLTGDWPYSAPLS--CDLGGRDLHGSHL--GGSPA
CYALA--TD-LP----SVPEAAEA---WEA-AMNSCSWSLRELLLRDEMDGTSSNCSCAT
SELEGTPSPSAVHSDFDVDV----------LHRQRPDGL--GDRERFLLTG-TYFDL-GE
GGGPHES--CPEHRPTEPPELYL-SPERCEASDTESPDRGLPTMD-TSLEDAHPSAEDPR
PDAWVTSTP--------VTPGAASLCLEIQEGTYSGSCYHRDGLR-----LSMSPAVGRG
GAHGPL---EPILVKDLLHSHR-DSATRTRLLLASLASSTHSM-PEPPGPSLGEVL--RA
KTRPEEAPLPVELEGLAACEGEYSHKYS

PF00069 // ENSGT00760000119045_0_Domain_3 (1349, 1612)

TLCPLGS-GAFGFV---WTAIHKDRN-KEVVV
KFIKKEKVLEECWIEDPKLGKVTLEIAILSSVEHSNIIKVVDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASYIFRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFHTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFQ
ENPFCEVEETVQATIHPPYLVSQELTSLVCGLLQPAPEQRTTLEKLMTDPWVTQPVNLAE
YTWEEVYRTNKP-EGSLLSTGSLELRTG----SRSLSEAAGDRRLH----GPPGPAEAPS
GQCCSGPEDPSPLVS-----------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVSAEGPAAQT-TAEPSRSFSSAHR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPS-EPRG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVTNDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 358)

QSDGTVTSCDSLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKS--QPSSE

ENSGT00760000119045_0_Linker_1_2 (358, 394)

EA-
-TT------GE--AAPVRGYRASVWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVGDESGCGERTLDP-WQGQDPAEG
GQ---DPRINV------VLAGGHVVPRD------E-TRKLMES--QD-IFTGTQTEL-IA
GGQ--LLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ITAL
GREEPV-AIESPR---------QDLLGESR----SEPVDVKPF--ASCEDSEAPVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSGSDLW---AGAAVAEPQAKGQLAGGSLLMHCPCY
GSEWGLWWRSQDLAPSPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LIKEQLSQLSLAGALDV---PHAELVPTECPAVTAPVSS-CDLGGRDLCGGCT--GSSSA
CYALA--AD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSNCSCAT
SELRETPSSLAAGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CVGHDPTEPLEVCLVSSEHYAASDRESPGCVPSTLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMRGAAGLQREIQEGAYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTMSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRVNKP-ESGVLSTASLE--MG----NRSLSDVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRLLTS-----------------------

------------------------------------------------------------
---RRSRLTGLCRRGVSLS-GEKWSSYCFSSLAAHNVCASKIGNSWAQRDSCSLS-ISVG
SS-SCSFVHAPALEESS

PF00989 // ENSGT00760000119045_0_Domain_0 (138, 252)

QRFLTAARNPNQAIFTVDVTTTEILVANDKACRLLGCSSQELI
GQKLSHFISKCNQETREAVDDEYLETDECSSMVSGTVVISINHLKEKIPVSVWLRRIRIK
DNQRCVVLLEPVERLSAFVSFRADGRICAHFSQEAHL----------------DINESKY
QVVGLHIKDLIPAVQIPLLGKKIPKNLKVQRAVGRSREGNVFPLTLKL------------
------QTERE-ISFPDYHYTAAVEVFSTISGLITVQSDGTIQCIKDSFALTLFGYEKKE
LLGKNITFLIPGFYNNMERSND-CSLPLPPLDDSLGTDSECFFEDVSACH-MTGSGCRSK
DL-------HV-VLIKF-------WDSP------P-TGYQVFHHRPWKVITPYLAR----
---------------YETVDGYFLPWYPLTGVALRPEI-NLDKELIHNGDSIVADELP--
-----AHCAEPSPETQPDRIRALEH---------------------------------CR
VVEN-------------------------GRSCYPPEMHPAWVSPS--------------
SSASEQ----------------------------------LGLNQNL-KTPLRSSHSAAS
GTSETGNASES-----------SFLLNQLH-VHHQDPKELNCQ-----------------
--QV-SMLLYEMLKDQPST-----------------------SAQGQSSSANVACFTIFS
SPVDELDTASRGLSKQL---SCLPCNSSGTPKINEPPPGTTLSCTQDF---------QSH
VARGQLAKTSFMCDGKH---SSLEHSVAESSLLKDANF--IANGRNSIHDGGS--GNTMG
CTGSA--LG--------AAPTFRTVRQTDA-ELNYICSDLEELDLNIGVTGNSGNCLGST
SDFVGGFFSNTVNSAAGN------------MSTQS-GVS------SAELNGV-AI---KD
GSGYLPSRQHLENPE-QSLEVFIEKPKTLTETVGDNVNRNIL-KSKGNPEEDCQLHGQEN
MEIKATSTPVKQEG---RPNHAAPFSAEILEGSYSGNCSHKDGSQ-----LSILFEVKRV
ELQDPTVLFCVWVVKDLLQSQK-EAAAKTQLLLSSLASSTQSV-LDLSTHSLGEAI--KS
SSLSENSRRAEELERLRACEGEYTKH

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YHALSLIGK-GSFGFV---WTARSKTNH-QEAVV
KFIWKERVLEDCWVDDPDVGRVTQEIAILLKLQHPNIIKVLDVFENERFFQLVMEKHGSG
LDLFTFIDNQPDLDEPLASYLFRQ-------LVSAVGYLHCRNILHRDIKDENIVIAEDF
TIKLVDFGSAAYLQPGKLFYTFCGTIEYCSPEVLSGKPY-HGPELEMWSLGVTLYTLIFA
ENPFCELEEAMAAVLNFPRPVSKDLMNLIVGLLHPAPEQRTTLAMLVEDPWLKQPVNLGD
YTWEEV------------------------------------------------------
--------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MSLGLRG-GKCGGHVCHM-DRWWPLVSWDAPG-L---ASAASVLFS-

PF00069 // ENSGT00760000119045_0_Domain_3 (1376, 1612)

SQVVV
KFIKKEKVLEDCWIEDPDLGKVPLEIAILSRVEHANIIKVLDVFQNHGFFQLVMEKHGSG
LDLFAFIDCHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAE
YTWEEVCQVNKP-ESGVLSTASLE--LG----SRSLSEVAQAQALC----AGPAPGEAPD
GHGCLHPRDPRLLTS-----------------------

-----------MEDR-GS-PALEKDWRCLCGNPSSLAPSEGPAVQT-SPQLSKSVSSAHR
HLNRRNGLSKLCQSRMALS-EDRWSSYCLSSLAAQNICTGKVQ-CTAMAEQADPA-GFLG
SMSCCSLLRGLSSGCSTPLLPAPAGNPNKAIFTVDAKTSEILVANDNACRLLGYSSHDLI
GLKLTQFFLKPDCDVVEALSEEHVEADGHAAVVFGTVVDVVSRSSERIPVSVWMKRMKQE
PRLCCVVVLEPVERVSAWVSFQSDGTITSCDSVFAHL----------------HGYECGN
EVAGQRITDLIPSVQLPAPGQPLPQNLKIQRSVGRAKDGTTFPLSLKLKP--KPNSKEA-
-EA------GQ--AAPEQGYSASIWVFSTISGLITLLSDGTIYGINHSFALMLFGYGRTE
LLGKNITFLIPGFYRCMDLVNE-GSLPLPDLVSRLDMGNRSEPGETTVDP-LQGWSTAEV
GG--RDPGINV------MLAVDHMLPPD------R-TPKPAGS--QE-VVTGTQTQV-DT
GVR--LPSP---------L--SSLPTL--------------------GFQDIPEGSPP--
-----AHRQLSSPEDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------DTVL
EKQEPT-GTESLR---------QELLRGSR----SASVDIRPF--ASCEDSEALTPAEDR
SWG-EVCGLS--QAAQLECMGLSTANH-------------QADAAGQLAEVGLPVLHPGY
GAEWSTPQGSPATAASPSGPSGTARLSCS-IPLEEQWLGAQDD-REEL---------QTC
LLKEQLSKSSFGRPQDI---SSIELVPAEHTAFSTPVSL-CDLGGRDLYSGHS--GSSSA
YYALA--TD-LP----GVLDTVEA---PEA-DGNSFLWNLREVFYSRWTDRTSSNCSCAS
SELVGTASPSLAGSDVDVST----------LHGHRAEVL--DDRELLLLTG-TYFNL-GE
GRQFCET--HLGLNQREPSDT----SECEDVSGRESPGCVLPRLE-SSPMDMCPL-EEPR
SSIQVTSTPVRGDS--SATSGTTSLQQEIQEGTYLGSCCHRDGSL-----LSVQFEVKRV
ELQGPAPLFCCWLVKNLLHGQQ-ASATHTQLLLASLPSSTHSA-CEHPGPSPGEML--RS
RPWFEEPPKAGELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTALDRDQN-KEVVV
KFIKKEKVLEDCWIEDPTLGKVTLEISILSRVEHANIIKILDIFENQSFFQLVMEKHGSG
LDLFAFIDHHPSLDEPLASYIFRQ-------LVSAVGYLRSKSILHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-KGPELEMWSLGVTLYTLIFE
ENPFCELEETLEAAINPPYLVSEDLMNLMSGLLQPVPERRTTLEKLVTDPWVTQPVNLAD
YTWEEVCGINKP-ESRVMSTVSLE--VE----SRSPSEVAQHPELA----APP-------
--------------------------------------

-----------MEDR-GS-GAFGNEQRCLSGSFPLPVQMESLATEG-TSTPSRSFSAAHR
HPSRKHGLAKLCQSRTTLS-EDRWSSYCLSSLAAQNICTGRPH-CPGLPERSDLA-GSLG
SVSCCSLLRGLPLGSSAPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 206)

AVFTVDAKTTEILVANDKACELLGFSSHDLI
GRKLSRFFLKSDSDVVEALSEEHVEADGCAAVVFGTVVDIVGCSGEKTAVSVWMKRMWRE
RGRCCVVVLEPVERVSACVAFQCDGTITSCDSLFAHL----------------HGYLSQE
EVAGQRITDLIPSVQIPPPGDHIPESLRVQRSVGRARDGTTFPLSLKLKSK--PRPDER-
-EDGP--------PLPVPGYTASVWVFCTISGLVTLLPDGTIYGINHSFALMLFGYGKAE
LLGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXX----X-XXX---X--
XX----X--XX--------XXX-XXXXX------X-----XXX---X-XX---XXXX-XX
XXX----X-------------XXXXXX--------------------XXXXXXXX--X--
-------X--X-XXXXX-------------------------------------------
-------------------------------------X-X-XXX-----------XXXXX
XXXXXXTDTAGGHLPARDQ-----------------------------------------
-------HTQRDQ---------GERPGGRR----PEPRDESPH--AACEDPRSPASVEDG
ERKVPEG--------------------AARVTPRVETTVLKPSPASQLAGASFPIHCPQC
GTELLIRKGDL----RPP---VTTYVSLGTEIVDELWLDQGRD-REEL---------QTC
LVKEWLSAPSFAEGTAV---PSVRPLPTLHPTFAAPLPP-CDFRGRDLQGGRS--SSSSA
CYALA--TD-LP----GILEPRDR---QDA-DVATVSCGLKELFLSERAARAPSSCSCAA
SGLTKAPSSLSMGFSLDGDS----------PSGQCLGA----DWEGLLLXXXXXXXX-XX
XXXXXXX--XXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXAGPASVYFLAQGLE
PGFRVTSTPVRGES--APWPKPASPSQEIQEGSYVGSCYHRDGSR-----LSMQFEVRRV
ELQGAASLFCCWLVKDLRRGHR-DAAARARLLLASLSSSSHSA-AELPGPGLGEAL--RD
KPWLEEPPRAAEVEGLAACEGAYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEQG-KEXXX
XXXXXXXXXXXXXXXXXXXXXXXLEISILSRLEHASIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDHHPNLDEPLASYIFRQVRAR-QGLVSAVGYLRSKGIIHRDIKDENIVIAENF
TIKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLMGNPY-QGPELEMWSLGVTLYTLIFE
ENPFCELEETVEAVLKPPHEVSKELMSLMSGLLHPVPEQRTTLEKLVEDSWVTQPVNLAD
YAWEEVCRVSKP-DGGVLAGMSTE--AE----RRSPGEARGPEGVP----QSP--SQAPG
HRS--SPTCP----------------------------

-----------MEDG-GS-MASTEDYQGPGGSPSLSVPPEGHAAPA-ASEPGRSGSSAHR
HLSRRTGLSKLCQSRIALS-EERWSSYCLTSLAAQSICTSKLH-CSATPGQADRT-GSLG
STSCCSLLRGLSPGWSTPLLPAPVCNPNK

PF00989 // ENSGT00760000119045_0_Domain_0 (150, 236)

AVFTVDAKTAEILVANDRACRLLGHSSHDLI
GQKLTQFFLKPDPDVVQALSEEHVEADGHAAVAFGTVVDIVSRSGERIPVSVWMKRVKQE
CSLCCVVVLEPVERVSAWVAFRSDGTVTSCDGLFAHL----------------HGFASGE
EVVGQRITDLIPSLQLPAPGEHVPTHLKIQRSVGRARDGATFPVSLKLKS--QPGSEEA-
-TD------GE--AAPGGGYSASIWVFSTISGLITLLPDGTIYGINHSFALMLFGYGKAE
LLGKNITFLIPGFYHHMDLAYD-SSFPLRDLASCLDAGSQSGPGVSTGDE-PAGTAQAAE
GGTDSGR------------GNVTVVSTG------R------------------ECSL-SD
GV----CQA---------L--V-----------------------TDTLFSF--------
------------------------------------------------------------
-----------------------------------SRIHR----VRLIDTAQVSSC-RSQ
SPPERPRDVPEGGPPA-------------------RSGSSSPEGQ----------QRSVS
EQEQPV-TAELLS---------WGLQPGSR----SELGDTKPS--TSQEDSEAAIPGADR
SGGDETHGPC--QEVREGRGGTSESG---QG---PDAATAAPHTEGHLAGQD-------P
EGEQSVLPGSPRSAPSAP---GTLQLLFSTPPLDEPWLGAQQD-REEL---------HTC
LIKEQLSASSLAGPWGV---SYAELVLMGQPPPSAPASL-SDLRATDPRGGRS--GSSSA
CYALA--TD-LP----GALEAVEV---TEA-SENSFSWNLKELVFRDWTDRTSSNCSCAT
SELGGTPSPSLVGSDADVGA----------LPRPRSDVL--DDRELLLLTG-TCVDL-GG
GRRFRES--HLGLEETEPSQTCLVSSEHRDVNGLDSPSCVLPVPG-AGPEDECPL-EAPG
LSLQVTSTPVRAEGPGPAPLRAADLQPEIQEGTYTGSCCHRDGSQ-----LSVQYEVRRV
ELQGPAALFCCWLVKDLRHGRL-DSALHTHLLLASLPSSAHST-CEPSAASLGEVL--GT
KPWFEEPPKAVELEGLAACEGAYSLKYSTL

PF07714 // ENSGT00760000119045_0_Domain_3 (1351, 1608)

SPIGS-GAFGFV---WTAVDKEAN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILCKVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPSLDEPLASYIFRQ-------LVSAVVYLRSESILHRDIKDENIVIAEDF
SIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSMGVTLYTLIFE
ENPFCELEETMEAAINPPYLVSEDLMNLMSGLLQPVPEQRTTLEKLVTDRWVTQPVNLAD
YTWEEVCRLNKS-GSRALSTVGLE-LDG----R-SPSAAARAPEPH----RPSCSRVGSR
APAGPAPCRAADSLREAR-----------LSQAPSVRE

-----------MSAKEGP--SSKE--ASLGSSVTQ-------SLPGVCEELSKTF--PWT
SKKRKSGLSKLCKKKTSLT-ENGWNSYCLSSLAARNICTSKLHNSWTQLKSTSLS-CSIC
NASSCSLLNVLALGESTQALPTSIRNPN

PF00989 // ENSGT00760000119045_0_Domain_0 (149, 209)

KAIFTVDVRTTEILVANDKACKLLGYSTQEVI
GQKLSQMISKSSWDIMEALKEEHADAEEHENVIPGIVVDVISRSSEKIPVSVWTRRIKTP
QNKYCVVVLEPVERLSATVFFTSNGEIVSCDPLFAHL----------------HGYAASE
DVIGHYITDLIPSIQIPTPGKKIPQNIKIQRSVGRAREGTTFPLSLKLKVNLPDQDKNN-
----------TPSFPVNCSFCATIWVFTTINGLITVQADGTIYGISNTFSLMLFGYEKKE
LLGQNITFLIPGFYKYMDKAGN-SSLQLRRSRGSSDAENESKFKQTRMDG-CGTVEIN--
----EDSGITP------YTAGDMSS-LG------LQEQELTGSDEGQ-FHTGNGTQQ-GN
GGS--LLSF---------L--SPPPQA---------------STPVNGYVSYSRDSTVS-
--MNVS----------------------------------------VADQILSSERVS--
------------EGVSTDHQA---------------------------------------
------------TKPV--------------------------NSQQCEISSPNKSQSELY
ALES-----RAEQQEKDFVGKSCGLLQGEEEEEEGDTIDTHS------------------
-----FCFPYEMMESVP----IIK----------SDGAELQNREERQLDG----------
--------------------------EFNLPSLVLPHAEVST-----------------S
LNS-----------------------------LTFSVSN-TMLSCANCLLGCS--CENEA
CFPQQ--LHMEP----SVLEVVEG---KTTDVTDSLCCDLKDLGIRSG-----EVCSA-T
PELTQL-----SLNEEDHGQ----------FLNQTNNTSASNQI-DLLLKGESPT---GC
QRNLLAS-KHSGLSSLDV-------ARNCSSGSGESTGRHLEI---HSPGNEERSQEEFM
ALKQVTSTPVKVLSPG------ISLNNEIHEGSYSGNCYHRDGSR-----LSILFEVKRV
ELQDPAALFCIWVMRDHFQSQK-EAAAKTHLLLSRLASSSHTV-VDVSAVNLAELI--KT
TPLFENSRRVEELEKLKACEGEYEKKYDTLGL

PF07714 // ENSGT00760000119045_0_Domain_3 (1353, 1604)

IGK-GAFGFV---WTAKCRKDQ-KEVVV
KFIWKERVLDYCWVEDPELGTITQEILILRKLQHPNIIKVLDVFENRQFFQLVMEKHGSG
LDLFTFIDNQPNLDEPLASYIFRQ-------LVSAVAYLRCQNILHRDIKDENIIIAEDF
TIKLIDFGSAAYLEPGKLFYTFCGTIEYCSPEVLSGNPY-LGPELEMWSLGITLYTIIFG
ENPFCELEETMDPVLRPPYSVSDGLMDLLSGLLQPFPEDRTTLEVVVKHPWVTQCVNLAN
YTWEEVF-----------------------------------------------------
--------------------------------------

-----------MEDP-GP-STVDKDGRSLSGSVFVPAPTKGPSAQA-ASEPCKPL-SARR
HLSRKDGLSKLCQSRMALS-EDRWSSYCLSSLAAQNICTSRLR-CPTAPEHVDLA-APLG
NASCCSLLRGLSSGCSVPLLPAPASNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

IFTVDAKTTEILVANDKACGLLGYSSHDLI
GQKLVQFFLQPNSELAEALSEEHMEADGHAVVVFGTVVDVVSHSGEKIPVSVWMKRVQQE

ENSGT00760000119045_0_Linker_0_1 (241, 262)

RGLCCVVVLEPVERISAWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 343)

QSEGTITSCDDLFAHL----------------HGFASGE
DVVGQPITDLIPSLQVPPAGQPVSESLEIQRSVGRARDGTTF

ENSGT00760000119045_0_Linker_1_2 (343, 393)

PLTLKLKP--KCGGKAA-
-AMGEAAPEGE--AAPRQGYWASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 447)

LITLLPDGTIYGINHSFALMLFGFRKTE
LLGKNITFLIPGFYHYMDLAYN-SSL

ENSGT00760000119045_0_Linker_2_3 (447, 1347)

QHPNLTSCLDMGSESRSGEMTSDP-CHD------
------AKVDL------VLASDHVLPQD------E-TLKLVGS--QD-ISAGMQMQL-EI
GSR--LPAA---------H--SLQPSS--------------------EAGSVLEGHPL--
-----AQDKQSLATDQK----------------------------------------S--
----------IPEGHVPAHEKQSPSENQQDVSEKNPPMHGEWVL----------------
--PADLQDSQEGSLPAHGA-------------------WSLLTDQ----------QVTAL
RGAEPA-VAQIPM---------RGLLGESR----SGPVDTKPF--VSCEDNGPPVPAEDR
SSDVGMWDLH--QEAQRALTGASSAS------LQANATMPKPNAVGQPAGGGLPSYCPHY
RSEWLLRQPSPDLAPSPP---GVACVSFGTPTLDEPWLGGRAA-REEL---------QVC
LVKEQLSRLSFEGTLGI---SCLESVPEEHCPYTTPLS--CDLRGRDLHGSHL--GSSSA
CYALA--TD-LP----EFLEAVDV---RKA-ALNSCSWSLRELLLRDGADGTSSSCSCAT
SELEGTPSISAVSSDFDVDV----------LHRQRSDVL--GDRERFLLTG-TYFDL-GE
GQGSQES--CPEHEPTESPDIYLLSPEHYEASSTESPDCGLPTMD-ANLEYAHLSAEDPR
MSAWVTSTP--------VTPRDAGLCREIQEGTYSGSCYHRDGLR-----LSIHFEVKRV
ELQGPSSLFCCWLVKDLLHSHQ-DSATRTRLLLASLPSSTHSV-PESPGPSLGEVH--RA
KPREQESPTPVELEGLAACEGEYSCK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLRPLGS-GAFGFV---WIAVDKEQN-KEVVV
KFIKKEKVLEDCWTDDPKLGKVTLEIAILYSVEHSNIIKVVDVFENQGFFQLVMEKHGSG
LDLFAFIDQHPSLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLEKGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEATIHPPYLVSQELMSLMSGLLQPAPEQRTTLEKLMTDPWVTQPVNLAE
YTWEEVCRTNKP-ESSLLSTGSQEQETE----RSSTG-----------------------
--------------------------------------

-----------MEDR-GLT-AFEEDQRCLSQSLPLPVPAEGPAAQT-TAEPSKSFSSAHR
HPSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPA-GPGG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVANDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDVISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 344)

QSDGTITSCDGLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSVQHIPKHLKIQRSVGRARDGTTFP

ENSGT00760000119045_0_Linker_1_2 (344, 394)

LSLKLKS--QPNSEEA-
-TT------SE--AAPARGYWASIWVFCTISGL

PF13426 // ENSGT00760000119045_0_Domain_2 (394, 430)

ITLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYD-SSLQLPDLASCLDVGDESGCGEKTLDP-WQGQDPAEG
AQ---DPRIDV------VLAGGHIVPQD------E-TQKLVES--QD-IVTGTQTEL-GT
GSQ--LLSC---------L--SPQPAP--------------------GVDSVPDGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------VTAL
GREEPV-AIESPG---------QDLLGESR----SEPVDVKPF--ASCEDSAAPVPAEDG
GSNAGMCGLC--QEARLERMGVSGPSGSDLW---AGAAMAKPQAKGQLVGGSLLMHCPCY
GSEWGLWWQSQDLAPNPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LMKEQLSQLSLAGALDV---PHAELVPTERPAVPAPVLS-CDLGGRDLYGGFT--GSSSA
CYALA--TD-LP----GGLEAVEA---QEV-DVNSFSWNLKELFFSDQTDQTSSSCSYAT
SELRGTPSSLAVGSDPDVAS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CLEHDPTEPLEVCLVSSEHYVASDGESPGHIPSVLD-AAPEDTCPSAEEPR
LNVQVTSTPV--------MPGAAGLQREIQEGAYSGSCYHRDGLR-----LSVQFEVRRV
ELQGPTPLFCCWLVKDLLHSHR-DSAARTRLFLASLPSSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVQHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPKLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRITLEKLVTDPWVTQPVNLAD
YTWEEVCQVNKP-ESGVLSAASLE--MG----NRSLSEVAQAQELC----GSPVPGEAPN
GQGCFHPGDPRVLTS-----------------------

-----------MEDK-GP-PVFAEDWRCLSGSPLAQ---EGLATQT-PSELSKPLSIAHR
HLSRKNGLSRLCQSRMALS-EDMWSSYCLSSLAAQNICTSKLH-CSAAPEHADSAAGLLG
STSCCSLLRGLASGCSAPLLSTPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 241)

VFTVDAKTTEILVANDKACSLLEYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGRAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQE
RGLCCVVVLEPVERVSACVAFQSDGTITSCDSLFAHL----------------HGFTSPK
DVVGQCVTDLIPSMQLPPPGQPVPKCLKIQRSVGRARDGTTFPLSLKLKS--KPNGKAE-
-AD------SE--VTSEPGYQASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 441)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHSMDPA

ENSGT00760000119045_0_Linker_2_3 (441, 1347)

YD-SSVQLPDLVNCLDIGSKSGPGEMSSDA-QQDWELASG
AQ---GPRVNV------VLACDHMLSQD------E-TLKLVGG---Q-VSLRTQMCL-ET
RCQ---------------------SAL--------------------GVDSIPVY-----
-------GENSLPTDHQ--------------------SIPKRNLLAHGGQLLSQNQQD--
----------TPEESLPVLNEHLLSEIQKNTSEESPLTHRKLLL----------------
--PKAQQDSTEGSLPIHNE-------------------QLQPTGH----------HINVL
GKETPS-AAESYR---------QGLLEESR----SKQKDTKLFA-SSCEDSEPPVPAKGK
SSSMDVCSLH--QEAQLELMGVSSPSSPNLW---ADATMPEPHTTGQLAGGGFLTHCPQY
RNEWILQQRGQDLAPSPS---GMACVLLGTPTLDEPWPGVRND-REEL---------QTC
LIKEQLSKSSVGGTVGL--SSCVELVPAEHPPFTAPVSF-CDLGGRELHASRS--GSSSA
CYALA--TD-LP----GVLEAVET---QEM-DVNSYSWNLRELFLNNQTDRTPSHCSFTT
SELSETPSPSVVGSDLDVGV----------LKRQSSSIL--GDREMLLLTG-TYFDL-GE
GRQFQEM--GAGRGRAELSDIPLVSSEHYETSDLESPGCGPPVPD-PGSDGMCLPAEKPR
LSVQITSTP--------VAPGVPSLQPEIQEGIYSGSCYHRDGLR-----LSIQFEVKRV
QLQSSATLFCCWLVKDLLHSHR-DSATRTRLILASLPSSTHSM-PELSRSSFGEML--RA
KPWFEESPTPAELEGLAACEGEYSLK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTISPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSKVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPCLDEPLASYIFRQ-------LVSAVGYLRSKGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGRLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAVIHPPFLVSPELMNLLTGLLQPCPEQRTTLEKLITDPWVTQPVNLAN
YTWEEVCRTNQP-ESGLLSAASLE--LG----SKSPSEVAHTKGFD----GLPSPREAPG
DQHCLHLEDPSLPVS-----------------------

-----------MEDG-G-LTAFEEDQRCLSQSLPLPVSAEGPAAQT-TAEPSRSFSSAHR
HLSRRNGLSRLCQSRTALS-EDRWSSYCLSSLAAQNICTSKLH-CPAAPEHTDPS-EPRG
SVSCCSLLRGLSSGWSSPLLPAPVCNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

IFTVDAKTTEILVTNDKACRLLGYSSQDLI
GQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQE
H

ENSGT00760000119045_0_Linker_0_1 (242, 262)

RLCCVVVLEPVERVSTWVAF

PF13426 // ENSGT00760000119045_0_Domain_1 (262, 347)

QSDGTVTSCDSLFAHL----------------HGYVSGE
DVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSL

ENSGT00760000119045_0_Linker_1_2 (347, 393)

KLKS--QPSSEEA-
-TT------GE--AAPVRGYRASVWVFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 430)

LVTLLPDGTIHGINHSFALTLFGYGKTE
LLGKNITFL

ENSGT00760000119045_0_Linker_2_3 (430, 1347)

IPGFYSYMDLAYN-SSLQLPDLASCLDVGDESGCGERTLDP-WQGQDPAEG
GQ---DPRINV------VLAGGHVVPRD------E-TRKLMES--QD-IFTGTQTEL-IA
GGQ--LLSC---------L--SPQPAP--------------------GVDSVPEGSLP--
-----VHGEQALPKDQQ-------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ITAL
GREEPV-AIESPR---------QDLLGESR----SEPVDVKPF--ASCEDSEAPVPAEDG
GSDAGMCGLC--QKAQLERMGVSGPSGSDLW---AGAAVAEPQAKGQLAGGSLLMHCPCY
GSEWGLWWRSQDLAPSPS---GMAGLSFGTPTLDEPWLGVKND-REEL---------QTC
LIKEQLSQLSLAGALDV---PHAELVPTECPAVTAPVSS-CDLGGRDLCGGCT--GSSSA
CYALA--AD-LP----GGLEAVEA---QEV-DMNSFSWNLKELFFSDQTDQTSSNCSCAT
SELRETPSSLAAGSDPDVGS----------LQEQGSCVL--DDRELLLLTG-TCVDL-GQ
GRRFRES--CVGHDPTELLEVCLVSSEHYAASDRESPGRVPSTLD-AGPEDTCPSAEEPR
LNVQVTSTPVI------VMRGAAGLQREIQEGTYSGSCYHRDGLR-----LSIQFEVRRV
ELQGPTPLFCCWLVKDLLHSQR-DSAARTRLFLASLPGSTHSTAAELTGPSLVEVL--RA
RPWFEEPPKAVELEGLAACEGEYSQK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTMSPLGS-GAFGFV---WTAVDKEKN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQ-------LVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLVFE
ENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPEKRTTLEKLVTDPWVTQPVNLAD
YTWEEVCRVNKP-ESGVLSTASLE--MG----NRSLSDVAQAQELC----GGPVPGEAPN
GQGCLHPGDPRLLTS-----------------------

-----------MEDR-GP-PAFAEGWRCLSGSPAQ----EDPDGQA-ASEPSKSPSSVHR
HLSRKNGLSRLCQSRMALS-EDRWSSYCLSSLATQNICTSKLH-CPAAPEHTDPLPGPLG
STSCCSLLRGLPSGCSASLLSAPVYNPNKA

PF13426 // ENSGT00760000119045_0_Domain_0 (151, 242)

VFTVDAKTTEILVANDKACSLLEYSSHDLI
GQKLAQFFLKSDSEVVEALSEEHVEADGRAAVVFGTVVDIVSRSGEKIPVSVWIKRVQQE
RGLCCVVVLEPVERISAWVTFQSDGTITSCDVLFAHL----------------HGFMSAK
EVVGQCVTDLIPSMQLPPPGQHVPKSLKIQRSVGRARDGTTFPLSLKLKS--KPSGKAV-
-DD------SE--AAPDPGYQASVWAFCTISG

PF13426 // ENSGT00760000119045_0_Domain_2 (393, 441)

LITLLPDGTIYGVNHSFALMLFGYGKTE
LLGKNITFLIPGFYHYMDLA

ENSGT00760000119045_0_Linker_2_3 (441, 1347)

YN-GSVQLPDLTNCLDIGSTNQPGD----V-RQDWGLASR
VQ---DVEVDV------VPPCDHVVLSQ------D-ETLKQER--QE-VFPGTHTRL-ET
GNP--T-PS---------H--SSQPSL--------------------RVDSNLAR-----
-------SEQSLPTDQQ--------------------SIPERSLQGHGRQLLSKNQPD--
----------TPEGTSPVH-HELLSEIQKNISEESPPIHREWLL----------------
--LKGQQDTVEGSLPVHEE-------------------QSLLLDQ----------RVTVF
RKKDPA-TVESSR---------WSLLGESS----SEPVDAKLIVPLGLEDSEPPVPAKPR
NSSMDIYSLH--QEAQLELMGVSSPS---PW---ADATMPEPHTTGQLAGGGFLTHCSHY
RSECILQPRGQDFAPSPS---GMACVLLGTPTLDESWSGVRND-REEL---------QTC
LIKEQLSKSSFTGTLGI---SCVELVPAEHPPFTAPVSF-CDLGDRDLHGSRS--GSSSA
CYALA--TD-LP----GVLETGET---QEA-DMNSYSWNLRELFLSDQTDQTSSDCSCAT
SEFSEAPS-SVVDSDLDMGV----------LHRQKSDSM--GDREL-LLTG-TYFDL-SE
GRRFQKI--GIGHDQRELSAISLVSSKHYEASDIENPGCDLPTPE-PGPEDMCLSAEGPR
LSAQVTSTP--------VAPGTSCPQQEIQEGTYSGSCYHRDGLL-----LSVQFEVKRV
ELQGSATLFCCWLVKDLLHSHW-DSVTRTRLLLASLPGSTHSM-SELSGSDLGGVL--RA
KPWFEESPTPAELEGLAACEGAYSHK

PF00069 // ENSGT00760000119045_0_Domain_3 (1347, 1612)

YSTLSPLGS-GAFGFV---WTAVEKEHN-KEVVV
KFIKKEKVLEDCWIEDPKLGKVTLEIAILSKVEHANIIKVLDVFENQGFFQLVMEKHGSG
LDLFAFIDRRPSLDEPLASYIFRQ-------LVSAVGYLRSQGIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPY-RGPELEMWSLGVTLYTLIFE
ENPFCEVEETMEAAIHPPFLVSQELMSLVSGLLHPAPERRTTLEKLIIDPWVTQPVNLAN
YTWEEVCRTNQP-ESSLLSTASLE--LG----RRNPSEVAQTKGVC----GPPAPREAPG
GQHSLHPEDPSLPVS-----------------------