Query Results 

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSPRGIEYILSNPAYARQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSVIMGELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRSEFVGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLHVCGGVNM--------------NSHQEVFASLFHKVSCSPASTQLLSMLQGLL---
-HLEPTHRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRLRPSPL--
-------DKAHKSVQ--ADLGQSQ---RGSSPENG------------------TAPEASV
EG----QQ----------------------------------------------------
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----------LVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREGSSM----WAALGSPN--TETVEPDF-------SSIERLFSFPVAKPREPA-AA
AQARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVTAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFREDRAKLASADQFYLLLLGVPCYQLRVECMLLCGGAAVVLDTVRP
QAQLVLAACESLLTSPQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPRDLEQPSQAAGINLEVIHSEASSNLRKLL
ETEQKVSASVPEVQEQYAGRLQA--SIEASQALDKLFEDIEQKRRELADYL--CE-DAQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKERKDQAARAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---GRKGPGKQEEICVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRTDADRGSK-AATGNPPGATE-SA
AS---RDPA-------GGPRSGTRC-PTS---GPGLDAAA-------TNEPPGWDLVDAV
TP--SP--------------QPTQEPLEEGGPRPL-----ERRSSWYV-DASDFLAPEDA
-----Q-----CPQP------SEGAWPVTLG---------------------D------A
QALQPLKFSSEKP---PG-------TQSSS-HDAEGPASL------GGIRQAEADSTSQG
REDA-----GV---LSHSAGLPA--------------AGL--------------------
-GGEA---DEEDPAPESALDTSLDRSFSEDAVTDSSGSGTLPRAR--RA-----SKGPGR
RRK-KRSARSQ--EEVAPD-CDDSNT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLHTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAAVEPV------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPSTP-LLPGSSAEPPPPPPPP---
-----------------------------------PPP---------------PLP----
-D---LGATVPP-------------------------APPLSPPLTSSCEF-----PPPP
PPPLPVMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLA-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPVAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVQP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGSTHCPAS---KPDLDATM-------ASESRGWDLVDAV
TP--QPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPASL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

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MGRGFGGRCPDTSPQHRLALPRALM-CFQSLWVYAVRAPSDPTG------VQG-----EA
PT---DSTRLDLSCHLT----P------------AHSRVLFRINLELIRSESSTNLKKLL
EMERKVSSCIPEVQEQYAQRLQA--SIEASRALDEVFQAIEQKKLQLASYL--CE-DAQQ
LSLEDTFS----TMKAFRNLFLRAL--KDNKDRKEQAAKAERRKQQLAEE-EACRPRGED
---GKPGEARGPGSPRGAAPASDPRSSLPWRPGGTSHASRLQVPWAGSGGPTSCVSEGPW
GFSVRRGVGKQEDVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGSK-AAAGDPLRDKAPAA
T---RDP--------------------------AGDTSHP-------ASEPHGRDRVDAT
APGPKPTAD----------------PSEEEGPGPLGRRS-----SWYT-DASDFLAAEAP
-----Q-----APQP------SAGAWPVVLG---------------------G------A
QALKPLRLSGDKPPGATG-----------SSQDAEDPAGPRDACLA------EADSTVRR
P---------------EATGPRG--------------HG-------------------AT
GPGVAGDGDQEDTAPDSALDTSLDRSFSEDAAMDSSGSSTLPRTR--ERA----SKGTGK
RRK-KRPSRNQEGLGRKPK-AK--------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRVRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLDQSQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACQPV------DHAQSESILKVS---QP------------
----------------RALEQQAS-----T----PPPPPP-LLPGSSAKPPPPPPPPPLP
SVGA--------------KA--------L--PTAPPPP---------------PLP----
-G---LGAMAPP-------------------------APPLPPPLPGSCEF-----LPPP
PPPLPGLGCPPPPP-PLP-PGMG-WGP-PPPP-PPLLP-CTCSAPV----AGGMEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVEPDF-------SSIERLFSFPAAKPKEPTTVA
ARARKEPKEITFLDAKRSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETEWKVSASVAEVQEQYTERLQA--SISAFRALDKLFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-AASMDPPRATEP--
--VATSNPAGD--------PVGSTRCPAS---EPGLDATT-------ASESRGWDLVDAA
TPGPQPTLEQS----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------P----AAGSSRQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSGKEGVQKKWAALKEKLGPQEG

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 186)

DPTE
ANLENAEPELCIRLLQMPSVVNYSGLRKRLESSDDGWLVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAIMNAHQGIEYILSDQGYVCKLSEAL--DTSNVMVKKQVFE
LLAAL

ENSGT00760000118986_1_Linker_0_1 (186, 191)

SIYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 467)

EGHKQTLDALDHYKMVKSQQYRFSVIINELSNTDNVPYIITLLS------
VINAIILGTEELRARTQLRNEFIGLQLLDIL-SKLRDIEDADLLIQCDT--FEEAKSEDD
EELLRIFDGIDM--------------SNHQEVFSTLFNKVSCSPISVQLLSVLQGLL---
-HLEPTQQSSL---------------LLWEAL-EILVNRAVLLASDVHE-----------
------------------------------------SSIEEIVERLLSMKMRPQQSPKIH
S----LVKTAHKCIQ--TSLDIVE-----PSPKGSPKKN-------------ASGP----
----------------SAASDSTEIV---KAVSLQAAS--AAPEPLAPA-----------
--------PAAANLPPPPPPLPSF-----AWAPPPATPMF-SKACVSPPPPPPPPPPSLP
SLDG--------------IPPPPPLPGLGGIPPPPP------------------------
--LPGLGGIPPPPPLPGWAPPPATPMFSKACVSPPPPPPPPPPSLPSLDGI-------PP
PPPLPGLGGIPPP-------------------------PP---------PMNGIEEI---
----------VVAQVDHGLGFARVPNH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1281)

RKVNPPT----------LRMKKLNWQK----LP
SNVVRDSHSM----WASVSSLS--SEDMEPDY-------TSIEQLFCFPTTKAKEKN--T
APAKKEPKEITFLDGKKSLNLNIFLKQFKCSNEEITDMIRRGDRTRFDVEVL----KQLL
KLLPEKHEIENLKSFREEKAKLASADQFYLLLLDVPSYQLRIECMLLYEETVIMLDMIRP
KAEVIRKACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQSRVTLLHHILEEVEKNYPDLLQLPSDLEHISRAAGINIDIIHSEASTNLKQLL
EMERKVSSGIPEVQEQYEKPLQD--SISASRELEEEFKVIERKKVELADYL--CE-DAHK
LSLEDTFS----TMKTFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKDWKEQAVKAEKRKKQLEAE-EAKRPRGED
---GKI------------------------------------------------------
---IRKGTVKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTAKGKGDSENGLKGV-STETCKEKEAGE
VL---W----------GGG-DKGTRHPGRAKADVQEAGSG-------PKLGQGFDLAAAT
VGETWP--------------QD-----SPDGPGSV-----SVTEGA---GGHGRPSSEGS
-----S-ASTPMPSF------SEDPHL-------------------VRLD--D------S
TSLNPTKFSTGPP---PW-------GTDVGSEVDAIG-AE------DRGAEHRASRTAQG
PEDG-----CQ---RSEDAEPT--------------------------------------
--PPELEEEEEDTAPDSVLDTSLDRSFSEGAITDSSGSGTLPRSQ--ER----TKKGSGK
RRK-KRHPRSHEEAEVESD-SGDDKT----------------KWHCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VVNAIILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPA------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPPN---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------

PF02181 // ENSGT00760000118986_1_Domain_3 (871, 1281)

-PPA----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSSSAGE--------PVGGTHCPTS---KPDLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEEA
-----Q-----CPQP------LEGAWPVTLG---------------------G------A
QALKPLKFSGNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDANKT----------------KKPCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 405)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGQHLSRLS-SPRRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCDGVNM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDGERL-------DWT
G-----------------------------------------------HVGRQPPSAL--
-----PLDKAH-------------------------------------------------
KG---GQQP-------IVASACECV------VSVQSSSGDTAPQPLVLEQRVPTPPLPSP
PXXXXX--XXXXXXXXXXXX----------------X------XX---XXX--XX-----
---XXXXX--------------------------------------X----X--X-----
----XX---XXXXX-XXXXXXX---XXXXXXXXX--XXXXXXPPLPGMGC------PPPP
PPPLPGIGFGPPP----------------PPPLPGMSIPS---------MVGGVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAQERSSM----WAALSSPC--TEGVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTTMIQAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFKEERTKLANADQFYVLLLDIPCYQLRVECMLLCEGTAVVLDMVRP
KAQLVLTACESLLTSHRLP----IF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPQDLEPPSQAAGINLEIIRSEASANLKKLL
ETEQKVSTSVPEVQEQYSKRLQA--SIEASQALDKVFEAIERKKLQLADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMVKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEAGSK-VTPADPLKPTEPGE
TL-------------------ACPAHPAT---EPGLDATA-------ASEPQGWDLVDAM
TPSPLP--------------------SEEGGPPAL-----ERRSSWYV-DASDFLVPEDT
-----L-----NAQP------STGTWPVTLG---------------------D------D
QSLKPLEFSSNKP---PG-------AENSH-QDAADPEVL------WGIHQAKADSTSEG
LEGT-----PE---YSRGAHLPD--------------TGPV-------------------
-----RDEDEDDTAPESALDTSLDKSLSEDAVTDSSGSGTLPRDR--GR----ASKGASR
GRK-KRPTRNQE--EVAPD-SDANKT----------------KRLCVIQ-----------
-----------

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--------MAPP-------------------------APPLPPPLPGSCEF-----LPPP
PPPLPGMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCSRPV----AGGMEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVEPDF-------SSIERLFSFPAAKPKEPTAAA
TRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA-SGISAFRALDELFDAIEQKQRELADYL--CE-DTQQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEGGSR-AASMDPPRATEP--
--VATSNPAGD--------SVGGTRCPAS---EPSLDATM-------ASESQGWDLVDAV
TPGPQPTLEQS----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------P----AAGSSRQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

ESDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQT-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--ANLGQNR----DSSSLNT------------------TTPTAKV
EG----QQL-------AVASTCQHV------GSSQSPSDDIAPQTAL---QQAASPLP--
-----------------------------------TPPLS-SSTP---VLP--PPPPPLP
GQGTISPPAPPPP---------PPL------PP----PLPGSRTISP----LPPPP----
PPLPGSEAMSPPAP-PP-PPPP---PPLSDSWR---TQPPPPPPLPGMGGP--SLPPP--
PPPLPGTGGIPPP--PPPLPGFS--------------VPS---------MVGGVEEIIV-
------------AQVAPGLDSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSSPC--TEVVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APIRKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRP
KAQLVLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPRDLEPPSQAAGINLEIIRSEASTNLKKLL
ETERKVSASIPEVKKQYAERLQA--SIEASQALDKVFEAIEQKKLELADYL--CE-DAQQ
LSLEDTFN----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEAGSR-VAPTDPPKAPEPAA
AS---N-P-----------I-QGTDHPIS---EPSLDTTA-------AGEPQGWDLVDAL
APSPQP--------------S-----KEEGGPPAL-----ERRSSWYV-DASDFLVPEDT
-----P-----NAQP------SEGVWPVTLG---------------------D------A
QALRPLEFSSNKP---PG-------IESSQ-QDAMDAEAL------RGVHQAKADSMREG
AEDT-----AE---RGHSTHLPC--------------TGPGED-----------------
-------EDEDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVR--GR----VSKGTSK
RRK-KRPSRNQE--EFVPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLS------
VINAIILGPEDLRARAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRISNGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--TNSVQNQ----GSSSQNT------------------TTSTTKV
EG----QQP-------VVASPCQQV------GSIQSSSVDIAPQPVALEQCITALPLPTP
-PLSS----STPVLRPTPPPLPGP-----G-ATSPLPP-----------PPX-XX-----
------------------------------------------------------------
-------------------------------------------------------XXX--
XXPLPGMC--PVPPPPPLPRAGQIPP---PPPLPSFSVPS---------MMGGVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLGSPC--TAAVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRP
KAQLLLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLL
EAERKVSASIPEVKKQYAERLQA--SIEASQELDKVFDAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAERRKQQLAEE-EARRPRDED
---GKP------------------------------------------------------
---IRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEASGR-VAPTDPPKATEPAT
AS---NPT-------------QGRNHPAS----EPLDTTA-------ADEPQGWDLVDAV
TPSPQP--------------S-----KEEDGPPAL-----ERRSSWYV-DASDFLDPEDT
-----P-----DAQP------SEGVWPVTLG---------------------D------G
QALNPLEFSSNKP---PG-------VKSSH-QDATDPEAL------WGVHRTEADSTSEG
PEDE-----AR---RGQSTHLPR--------------TGP--------------------
----GEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQ--GR----VSKGTSK
RRK-KRPSRNQE--EFVPD-SDDIKA----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLDSSDGTWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSRQGIEYILSNPGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTACSQQYRFSVVMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRGEFIGLQLLDVL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPARRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------AKAHKSVQ--ANLGLSQ---RGSSLKNA------------------TD----V
-E---GQQP-------AAAHTCQHA------GSVPGESDVPAQQPQALGQRATTPPPPAP
-PLPG----TTTG--RPXXXXXXX-----X-XXXXXXXXX-XXXX---XXXX-X------
--------------------------------------------XXX----X--------
------------XX-XX-XXXX---XXXXXXXXX--XXXXXPPPLPGGGC------PP--
PPPLPGVGWGPPP--PP--------------PLPGTSGAP---------TVDGVEEV---
----------IVARVDHSLGSVWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------VRMKKLNWQK----LP
SNVAREGSSM----WASLGSPG--TEVVEPDF-------SSIERLFSFPAVRPKEPV-AA
APARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTTMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADQFYLLLLDIPCYQLRVECMLLCEGTAVVLDMVRP
KAQLVLAACESLLTSHQLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKTHPDLLHLPQDLEQPSQAAGINLEIIRSEASSNLKSLL
ETERKVSASVPEVQEQYSGRLQV--GITASRELDALFEAIEQKRRELADYL--CE-DAQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FVRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGEN
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGNK-VASADPPRVPEPAA
TG---G-PA-------GGS-ASVTRFPAS---EPGLHAVV-------AHETQGWDLADVV
TPSPQP----------------SQEQSEGGRAEAL-----ERRSSWYE-DASDVLATEDT
-----W-----CPQP------SEGAWPVTLG---------------------D------A
QALKPLKFSTEHP---SG-------ARSPS-QDTEDPTSS------GGVLQAEADSTSQG
TEDT-----AI---CGHGASLSA--------------TGP--------------------
------NGDEEDTAPESMLDTSLDRSFSEDVVTDSSGSGTLPRAR--GR----ASKGTGK
RRK-KRPSKSQE--EVAPD-SDGNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

DSDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPLTP-LLPGSSAEPPPPPPPP---
-----------------------------------PPP---------------PLP----
-D---LGATVPP-------------------------APPLSPPLTSSCEF-----PPPP
PPPLPGMGCPPLPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----VF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPAS---KPDLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAQ--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------TVQP
KAQLLLAACDXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXASLEASQKLAMLFEAIEQKRLELAAYL--CE-DPRQ
LSLEDTFS----TMKAFRDLFTRAL--KENKDRKEQMARAERRKKQLAEE-EARRPRGKD
---GKP------------------------------------------------------
---VRKDVGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEGASK-MAAAEPLRDTAPAA
TC---DPGG--------------------APRGHNLDATT-------DREPWDWDLADAA
APSPQP-------------------------VGTS-----DRRSSWYE-DASEVLVPEDA
-------------------------WPVILG---------------------S------D
QALRNLSFSQDKP---PT-------P--------------------TGVSQPDTDGTGQD
PEDT-----NA---TGP-------------------------------------------
----S-RNEDEDTAP-EAFDISLDQSLSE-------------------------------
------------------------------------------------------------
-----------

----------------------MPEKTVQPAKMSAKKEGAHK

PF06371 // ENSGT00760000118986_1_Domain_0 (43, 187)

KWAALKEKLGSQDSDQTE
ANLENAEPELCIRLLQIPSVVNYSGLKKRLESSDDGWMVQFLELCGLDLLLEALDRLSGR
GVSRISDALLQLTCINCVRAVMNSQKGIEYIVSNEGYVRKLSQAL--DTSNIMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSV

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 407)

DGHALALDALDHYKTVKNQQYRFSVIMNELSATDNVPYMITLLS------
AINAVILGTEELRARTQLRNEFIGLQLLDIL-NRLRDIEDVDLLIQCET--FEEAKSEDD
EELLKICDGIDM--------------SNHQDVFSSLFNKVSSCPASVQLLSILQSLL---
-HLEPSHHSSL---------------LLWEAL-EILVNRAILLASD

ENSGT00760000118986_1_Linker_1_2 (407, 694)

IQG-----------
------------------------------------NSVEEVMERLLSIKKPAKKRNS--
-------ESRRSVNRV-NESTQTSEDLGEHFKAAKNSPAI-------TCS----------
-SDIPPATDVSEKVAASQLPPCSAL------PGQNSNPPSMLP--LSSTPSPPPPLPPPP
PPLPGA-----QIPPPPPPPLPGM-----KGMPPQAPPLP----SM---AGIPPPPPPLP
GMAV--------------IPPPPPLPGL----P

PF06346 // ENSGT00760000118986_1_Domain_2 (694, 832)

PPPPPLP---GAVV-----IPPP----
PPLPG--------------------------------MPPPPPPLPGMTGI-----PPPP
--PLPGMPPP--PP-P--LPGMAGVPP-PPPL-PGMAGIPPPPPLL----G

ENSGT00760000118986_1_Linker_2_3 (832, 869)

GNIEEV---
----------VVARVDYSLGCA-RPIHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVKPPT----------LRMKKLNWQK----LP
SNVAREGHSM----WASATSSS--EETIEPDY-------TSIEQLFCFPQAKPKSKEA--
AAVKTEPKEITFLDSKKSLNLNIFLKQFKCSNEEVVDMIQKGDRTKFDVEVL----KQLL
KLLPEKHEIENLKSFKEEKEKLSNADQFYLLLLGVPSYQLRIECMLMCEETAVVLEMLQP
KAETIRRACEDLLSSHRLP----VF-CQLILKVGNFLNYGSHTGDADGFKIGTLLKLTET
KA---NQTRITLLHHILEEVEKNHIDLLQLPKDIEYVAKAAGINLDVIRSESSSNIKKLM
ELGRKLSSSTEEVKAQYEKAIQD--SINANKKLEDEFENIEAKKVELANYL--CE-DPNK
LSLEDIFN----TLKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIKAL--KENKDRKEQVAKAEKRKKQLEEE-EAKRQKGEN
---GKI------------------------------------------------------
---IKKGVVKQDDVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARNKGDPDTPAK-GSPSQPQKGKDTGS
TVQAVKDTMNEEDGVIVQNNLQGLLEKTV---ISGADAIN-------AKQ---EDVVDLP
--ASHTSSGDG----------GNG------RHTPS--HPDPDKSSLNSFTLERIMEPNNG
-----T-----NLQERTVSHSIQDMNDNDLE---------------------L------S
QSSSFIKFGSTDS-------SSWKSGGGLVCSG----GSD------FGFCSQNSLNSNDQ
VNKDIRKNSVVQDTSGEVQGLPT--------------SD-------------------VP
AATKESTKENNEPSIDSLLDTTHEKSFSEEPLTDTTCSATVPSEQ--ALVEKDSQKGSNK
RRKKKRHSKSNP--MVDTDLKAVGDT----------------KRGCEIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKMVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRCEFIGNCSPACLTSPPRDLEDADLLIQLEA--FEEAKAEDE
EELLHVCDGINM--------------NNHQEVFASLFHKVSSSPASAQLLSVLQGLL---
-HLEPSGHSGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLAGKVRPRPSLL--
-------DQAHKSVQ--ADLGQNQ---SDTLAQNT------------------TASGTGI
DA----QQP-------AVASVCQQV------ASTQSSSS-TAVQPTVPPQRAPSPPPPAP
SL-------PDPTTRSPLHHLPGL-----G-ST---------------------------
-----SPPAPP-------PPPPPPLPSLGATCLPPPPPPPPLPSL---------------
------GAASPPAP-PPPPPPP---LPSLGAASPPPPPPPPAPPLPGLGSSFSSVPPP--
APPLPGFGSALPPP-PPPPPGVGWGP---PPPLPGTSGLP---------MAAGVEEI---
----------IVAQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATMSSPG--TEQVEPDF-------SSIERLFSFPTAKPKEPT-A-
APTRKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEITAMIRAGDTAKFDVEIL----KQLL
KLLPEKHEIENLRTFTEERTKLANADQFYVLLLDIPCYQLRIECMQLCEGTAIVLDMVRP
KAQLVLNACESLLNSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPKDLDQPSQAAGINVEIIRTEAGTNLKKLL
DAEQKVSASIPEVQEQYKHRLQT--SITASRELDAVFSAIEQRKLELADYL--CE-DPQQ
LSLEDTFS----TLRSFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCSL--KENKDRKEQMAKAERRKRQLAEE-EARRPLGKD
---GKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGEAEGSSK-VASKDPLRVPEPGE
PL----PAA-------SG-PTGGTSDPAP---ELDLHAAV-------ASEPPGCDFVDTV
IPSPAS--------------H-----GKESGPPPL-----ERRSSWYV-DASDFLDTKDA
-----L-----NTCP------STEAWPVVLG---------------------D------S
HALKLLEFSSKEP---PG-------SQSSGPQDTEDPENS------QGVHLAKADSTSQG
PED---------------------------------------------------------
-IGPGGDEDREDTALESALDTSLDKSFSEDAVTDSSGSGTLPR----GL----ASKGSSK
RRK-RRPARSQE--EVAPD-SDDNKT----------------KRLCVVQ-----------
-----------

--------------------------------MSIKKEGAHKKWAALKEKLGP

PF06371 // ENSGT00760000118986_1_Domain_0 (54, 187)

QETDQSE
ANLENAEPELCIRLLQMPSVVNYSGLKKRLENSDDAWMVQFLELSGLDLLLEALDRLSGR
GVARISDALLQLTCISCVRAVMNSHKGIEYIVSNEGYVRKLFQAL--DTTNVMVKKQIFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSS

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 464)

DGHSLALDALDHYKSVKNQQYRFSIIMNELSNTDNVPYMVTLLS------
AINAIILGKEELRTRTQIRNEFIGLQLLDVL-DKLRDIEEEDLLIQCDT--FEEFKIEDD
EELLRICDGINM--------------NDHHEVFSSLFNKVSRSPVSVQLLSILQSLL---
-HLEPSHHSSL---------------LLWESL-DAVVNRALLLANDIQG-----------
------------------------------------NTVEEVIERLLSIKKHPNSPTT--
-------STLWHSSRE-PHI-----------------PHDKY--TSS--PSTAWHPS---
---PSTPIA---WHGGCSPSSSS-------------TIAWHAPPPLPGMVGIPPPP----
---------------PLPPPLPGM---G-GV-----PPP--PPPPLPGMVSIPPPPPPLP
GTGG---------------------------IPPPPPPLP---GMGG-----IPPP----
PP-------PLP-----------APLPGMVG------IPPPPPPLPGMGGI-----PPP-
------------PP-PL--PGMGGVPP-PPPLLPGMTGDHI-------------EAV---
----------VASQYSCPLGL-GRPPH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1281)

KTVKTPT----------LRMKKLNWQK----LP
SNVVRESHSM----WASVSSSS--EETIEPNY-------SSIEQLFCFPQPTPKEKTT--
APVKAEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMVQNGDRTKFDVEVL----KQLL
KLLPEKHEIENLKAFKEEKSKLANADQFYLLLLQIPSYQLRIECMLICEETTVVLDMIQP
KAEAIRRACEDLLTSHRLP----VF-CQLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEEVENSHKDLLELPKDLEYVSKAAGINLDIIRTESGTNLKKLL
ELQRKVLSSNEDVKQQYEKPIQD--SIDASRKLEEEFETIEKKREELANYL--CE-DPSK
LSLEDIFS----IMKTFRDLFIRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRQKGEN
---GKV------------------------------------------------------
---IKKGLMKQEEVCVIDALLADIRKGFTLRKTKN-RHESDAVPK-PLSAESLEESQSGK
-----DPQAAGKQTDD--KTKQNKDDHPS---ESTSPSTT-------APMETGGGVTNGS
ASGQVLSKNSA----------GGSLPLESQTKSPLVSMVEDDGASQTM-LGPRMEQANNV
-----E-----SLQP------STKSSSLAFS---------------------V------A
DIGSRISFVSSSPASALGDQLSWTNGSMSGGQDKQCPTEGSDS-----------------
A---------------Q-PAPCS--------------EA-------------------QQ
PESKEMTKENEDPGTDSLLDTSQDKSFSEEPATDSSCSATLPPEQ--THSDREKQRPSGK
RKKKKRHSKSYSEAEVETD-TGDNKT----------------KKDCVTQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRARTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLDQSQ---RGSSLQNTTTPK---------------------
-PSVKGQQP-------AAAAACEPV------DHAQSESILKVS---QP------------
----------------RATEQQES-----IPLPPPPPPPP-LLPVSSAEPPPPPPPPPLP
SVGA--------------KA--------L--PIAPPPP---------------PMP----
-G---LGAMAPP-------------------------APPLPPPLPGSCEF-----LCPP
PPS---------------------------------------------------------
----------------PLLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1210)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVEPDF-------SSIERLFSFPAAKPKEPTTAA
TRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSETSSNLKKLL
ETERKVSASVEASWGG---GFA--------------------------------------
---------------------------------------------------------GHS
---GRQ------------------------------------------------------
---WN-G-----GGCAW-----------------------AGSGA-GCLAFTGVSLHP--
--VATSNPAGD--------PVGSTRSPAS---EPGLDATT-------ASESRGWDLVDAV
TPDPQPTLEQS----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QDLKPLKFSSNQP-------P----AAGSSRQDAKDRTSL-----------AEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

ESDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGLWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSKQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 459)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGKCPHR----LPRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCDGVNM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------RTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--ANLGQNR---D-SSSRSA------------------AAPTAKG
EG----QQP-------AAASARPCV------GSSHSASGDTAPQPAALRQAA--SPLPTP
-PLCS-------------------------------------STP---VL----------
------------------------------------------------------------
--------------------------------------PPP-------------------
PPPLPGWLS---------------------------------------------------
--------------------------AEYLAPPS--------------------------
---LIE

PF02181 // ENSGT00760000118986_1_Domain_3 (907, 1281)

RNSM----WATLSSPC--TEVVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APTRKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTTMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADQFYILLLDIPCYQLRVECMLLCEGTAIVLDMVRP
KAQLVLTACQSLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINLEIIRSEASGNLKKLL
EIERKVSASIPEVQKQYAERLQA--SIEASRALDKVFEAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDMEAGSR-VAPTDPPKATEPAA
AS---NA-------------TQGANRPAP---EPSLDTAA-------AGKLQDWDLVDAI
TPSPQP--------------S-----KEEGGPPAL-----ERRSSWYV-DASDFLVPEDT
-----L-----NAQP------SEGVWPVTLG---------------------D------D
QALKPLEFSGDKP---PG-------VESSH-HDAMDPEAL------WGVHQAKADSTREG
T--------AE---HGHSTRLPC--------------TGP--------------------
----GEDEDQDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVR--GR----VSKGTSK
RRK-KRPSRNQE--ECAPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSVVMNELSGSDNIPYVVTLLS------
VINAIILGPEDLRTRAQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQSQ---RGSSPQNTATPK---------------------
-AGVEGPQP-------AAAPACQPV------ASAQSESLLKAS---QP------------
----------------RALEQRA---------PTLPSPVP-LLPGSSAEPPPPPPPPPLP
SVGT--------------EA--------L--PVPPPPP---------------PPP----
LPLLGLGAMASP-------------------------APPPPPPLPGACG-------PPP
PPPLPGMECPPPPP-PLL-PGMG-WGP-PPPP-PPPLP-GTCSPSV----AGDVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPH--AEAVEPDF-------SSIERLFSFPAAKPKEPATAA
ALARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADQFYVLLLAIPCYQLRIECMLLCEGAAAMLDMVQP
KAQLVLAACKSLLTSRRLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLELPRDLEQPSQAAGINLEIIHSEASSNLKKLL
ETERKVSASATEVQEQYTQRLQT--SISAFRALDELFEAIEQKQRELADYL--CE-DTQQ
LSLEDTFS----TMKAFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKRQLVEE-EARRPLGED
---GKP------------------------------------------------------
---VRKGPRKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEGGNK-AASVDPPRATEP--
--VATGDPAGD--------PVDGTCCPTS---EPSVDAAA-------ANKSRAWDLVDAG
THCPQPTLEQS----------GEG------GPRPL-----ERRSSWYV-DASEDLTTEDT
-----Q-----CPQP------SEGAWPVTLG---------------------D------A
QALKPLKFSSGQP-------P----AAGSSSQDAEDPTAL------LGVLQAEAGSTSQG
-----REDT---------VRPPT--------------AG--------------------P
GG--DRDEDEEDTAPESALDTSLDRSFSEDAVTDSSGSSTLPRSR--GRAS----KGTGK
RRKKR-PSRSQE--EVAPD-SGANKT----------------ERLCVIN-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------E

PF02181 // ENSGT00760000118986_1_Domain_3 (1160, 1281)

VEKSHRDLLELPKDLEYVSKAAGISLESIHAESSSNLKKLL
ELEGKVLSSKDDVKAQYETPIQD--SINALKKLEEEFETIERKKMELANYL--CE-DANK
LSLEDVFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIKAL--KENKDRKDQAAKAEKRKKQLEEE-EAKRQKGDN
---GKI------------------------------------------------------
---IKKGAVKQDDVCIV

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTAKNKTDQDTAPK-ASPAETPKEREPAF
EAIASNPQNANRPIILLQGITPTRESLPQ---ESTCKLQP-------SYKPLK-------
-----------------------------KVLGPLA---AAKGSAHET-KQ---KDASHH
-----A-----EKTP------ASEAA----D---------------------T------V
RVPGTV--ATETP--ASNEVLP--KG---NSPQQPCTDSSSLSSTEVGGVHQSINGGVSI
Q---------------EINGSCS---------------S-------------------QH
TGLRQAERENDDHAADSLLDTSQEISFAEEPVTDSSCSATVPPAQ--ARMDKEGQRGSGK
RRRKKRSTKSQ-SAEVDTD-TGDNKT----------------KSLCVIQ-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PILCLGEVAS------
-PSPALAAPAG

PF02181 // ENSGT00760000118986_1_Domain_3 (1092, 1281)

LLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPTS---KPDFDATM-------ASEPRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSGNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----PEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGSP

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

ESDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGKRPHL----LARDLEDADLLIQLEA--FEEAKAEDE
EELQRICDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLDPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--ANLGQTQ----DSSSQDT------------------ATPRAKV
EG----QPP-------VVASACQRV------GSIQTSPDGVAPQPAAPEQQAAS-PLPTP
-PLSS----STPVLPPPP------------------------------------PPPPLP
APPAPPPP----------PPLPPPLPASGTISTPL---------------PPPPPP----
PPLPGSKTTSPPAP-PP-PP------PLSDAWR---TLPPPPPPLPGMGCPP--LPPPPP
PPPLPGTVGGVPP------------P---PPPLPGSSAPS---------VVGAVEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSSPC--TEVVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APIRKEPKEVTFLDSKKSLNLNIFLKQFRCSNEEVTTMIRAGDTTKFDVEIL----KQLL
KLLPEKHEIENLRAFTEERAKLASADQFYVLLLDIPCYQLRVECMMLCEGTAIVLDMVRP
KAQLVLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPRDLEPPSQAAGINVEIIRSEASANLKKLL
ETERKVSTSVPEVQQQYAERLQT--SIEASRALDKVFEDIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENRDRKEQMAKAEKRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEAGSR-VAPADPPKATEPAA
AT---SP-------------IEGTNHPAS---EPGLDATA-------AGEPQGWDLVDAV
TPSPQP--------------S-----QEEGGPPAL-----ERRSSWYV-DASDFLVPEDA
-----L-----NAQP------SEGVWPVTLG---------------------D------D
QALKPLEFSSNKP---PG-------VESSH-QDAMDPEAL------WGARQAKADSTREG
PEDT-----AE---RGHSTHLPC--------------TGP--------------------
----GEDEDEDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVR--GR----VSKGTGK
RRK-KRPSRNQE--EFAPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNAMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHTLTLDALDHYKTVCSQQYRFSIIMSELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FDEAKAEDE
EELQRVCNGINM--------------NSHEQVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPTSRSGQ---------------LLWEAL-ESLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPRPL--
-------DKAHKSIQ--ANLDQSL---RDKSPQNS------------------TAPMVEV
EG---QQQP-------AVAPSCQRA------GGIQSSGDDLTPQPVAFEQRALVPPVPIS
-PLPS----SNVGIPPPPPPLPGL-----E-T----------------------------
----TSPPAPPP---------------------------------------PPPLP----
PPLPGLRAISHPAP-PP--PPP---LPDSCRTM-----PPPPPPLPGMGCP-------PP
PPPLPGMGWGPPPP----------------PPLPGSSAPT---------VGGGVEEV---
----------IMAQVDHGLGCAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREQNSM----WAALSSSC--TEAVEPDF-------SSIEQLFSFPVTKPKEPF-T-
APTRKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTTMVRAGDTTRFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADQFYVLLLDIPCYQLRVECMLLCEGTAILLDMVRP
KAQLALTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPCDLEPPSQAAGINLEIIHSEVTANLKKLL
ETEQKVSASVSEVQEQYTKRLQA--NIEASRALGNVFKAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQVAKAERRKQQLAEE-EAQRPRGED
---GKP------------------------------------------------------
---VRKGPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDSEVASK-AAMADPPKAPEPAA
AS---GPAQ-------N--LAGGTNHSAS---EPGMNATA-------ASEPQGWDLVDAV
IPSPQT--------------S---EAEEEGHPPAL-----ERRSSWYV-DASDFLDPEDT
-----L-----NTQP------SEGMWPVTLG---------------------D------A
RALKPLQISSNKA---HG-------AESLR-QDVGDPEAL------WDIHQAKADSTRKG
PDDT-----AV---QSHGTHLPT--------------TGP--------------------
----GGEEDKEDTAPESLLDTSLDQSFSEDTVTDSSGSGTLPRTR--GW----ASKGTSK
RRK-KRPSRNQE--EVAPD-SDDNKT----------------KRLCVIQ-----------
-----------

------------------------------------------------------------
-------------------------LRKRLESSD-DWMVQFLEQSGLDL-LEALARLSGR
GVARIS

PF06371 // ENSGT00760000118986_1_Domain_0 (127, 188)

DALLQLTCISCVRAVMNSQPGIQYILSNQAYVRQLSQAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 305)

EGHTLALDALDHYKTVCSQQYRFSVIMNELGDSDNVPYVVTLLS------
VVNAIILGPEDLRTRTQLRSEFVGLQLLDML-TRLRDLGDADLLIQLEA--FEEAKAEDE
EELLQACGGVNM--------------NSHQEVFASLF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRARTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSSL--
-------VKAHKSVQA--NLDQSQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAAYEPV------DHAQSESILKVS---QP------------
----------------RALEQQAS-----T----PPPPPP-LLPGSSAEPPPPPPPPPLP
------------------------------------------------------------
------------------------------------------------------------
----------SPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCSPPV----AGGMEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVEPDF-------SSIERLFSFPAAKPKEPTTVA
ARARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAATVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIVRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-AASMDPPRATEP--
--VTTSNPAGD--------PVGSTRCPAS---EPGLDATT-------ASESRGWDLVDAV
TPGPQPTLEQS----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------P----AAGSSRQDAKDPTSL------LGILQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQKKWAALKEKLGP

PF06371 // ENSGT00760000118986_1_Domain_0 (54, 187)

QDTDQTE
ANLENAEPELCIRLLQIPSVVNYSGLKKRLESSDDPWMLQFLEQCGLDLLLEALDRLSGR
GVARISDALLQLTCISCVRAVMNSHQGIEYILSNQGYVRKLSQAL--DTSNIMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 467)

EGHELALDALEHYKTVKNQQYRFSVIMSELSNSDNVPYVITLLS------
VINAVILGTEELWARTQLRNEFIGLQLLDIL-TKLRDIEDVDLLIQCEA--FEEAKSEDD
EELLKICDGIDM--------------SNHQEVFSSLFHKVSRSPVSVQLLSVLQGLL---
-HLEPSQRSSL---------------LLWEAL-EILVNRAVLLAGDVQE-----------
------------------------------------SSIEEIVERLLSIKRRPGGRPE--
-------ERDCTRKVH--KWTQTGPDTAQLLPGSETCPG---------------------
-TGHPGTPEWVEKEASTHLPACSVT------PE-QCVPLLSAPPPPLPGMAAPPPPPPPP
PPLPGI-----AAPPPPPPL--PG-----MAAPPPPP----PLPGMAAPP--PPPPPPLP
GMAA--------------PLPIPPSPGMA--TPPPPPPLP---SMAT-----PPPP----
PPLPGMA------------------------------TPPPPPPLPGMAA-------PPP
PPLLPGMAAPPPPP-PL--PGMA-VPP-PPPL-PGGIPPPPPPPPS----GGGGEEI---
----------LVAQVGYTLGYAPAPCR

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1181)

KKVNQPT----------LRMKKLNWQK----LP
SNVVRESHSM----WASTGSLS--DEAVEPDY-------GSIEQLFCFPTAKPKEKEP--
APVKKEPKEVTFLDSKKSLNLNIFLKQFKCPNEEIVAMIQRGDRTRFDVEVL----KQLL
KLLPEKHEIENLKSFGDGKAKLASADQFYLLLLGVPCYQLRTECMLLCEETLIVLDMIRP
KAEMIRKACQCLLSSQQLP----VF-CQLVLKIGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRVTLLHHILEEVEKSHPDLLQLPNDLELVSKAAG------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSLKEGAHTKWGVLKQKLGPQDPEQIE
GNMENADPELCIRLLQIPSVVNYSGLKKRLESSDD

PF06371 // ENSGT00760000118986_1_Domain_0 (96, 188)

DWMVQFLELSGLDLLLEALDRLSGR
GVARIADALLQLTCINCVRTLMNSHRGIEYIVNNEGYVRKLSQAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

EGHALSLDALEHYKAVKNQQYRFSVIMNELSTSDNVPYMVTLLS------
AINAIIFGTEELRKRVQLRNEFIGLQLLDLL-TKLRDLEDEDLLIQAIV--FEEAKSEDE
EELLKIYGGIDM--------------NNHQEVFSTLFNKVSCSPLSVQLLSVLQGLL---
-HLDQSHPSSP---------------LLWEAL-DILVNRAVLLADDCQN-----------
------------------------------------NNVEEVMDRLVTSKKHPSKEKRKP
D---KCTNQVNKSIQ-T-DKPKD-----ESCEEKTVKKD----------PVSSGIPADSL
QL---SDAL-------LALPACVSPLHTPLSGDITSPS------------HFPSPPSPVV
SNAIDRISTSSSLPPPLPPPLPGT-----E------------------LSLPPPPPPPLP
GMGGISL----------TPPPPPPLPGMGGMLPPPPPPLPG---MGGM---LPPPP----
PPLPGMGGML----------------------------PPPPPPLPGMGGM-----LPPP
PPPLPGMGGMPPPP--PPLPGMGGMPP-PPPPMFGMG--------------TFTDEV---
----------VVARVDYSLGYLPK-AY

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1282)

FKVNKPT----------LKMKKLNWQK----LP
PNVINDTHSM----WASASSS---NDTPEPNY-------SSIEQLFCLPQAVAKEPA---
APVKKPPKEISFLDSKKNLNLNIFLKQFKCPNEEVIQLIEKGDRSRFDIEIL----KQFL
KLLPEKHEVENLKSYQEDKAKLSNADQFYLLLLGIPCYQLRIECMLICEEVNLMTDVLRP
KAKVVSSACDDIISSHRLP----LF-CQLILKVGNFLNYGSHTGNANGFKIGTLLKLTET
KA---NQNRITLLHHILEEIEQNHTDLLQLPSDLENVSTAAGINIENMYSETSGNLKKLR
DLQNKISTAATDVKDQYEKSIQE--CMDALKEVEEQLTDITQKKVKLADYL--CE-DSAK
LSLEETFS----TMKAFRDLF

ENSGT00760000118986_1_Linker_3_4 (1282, 1398)

LKAK--KDNKDRKEQAVKAEKRKKQLADE-EAKRQKGEN
---GKI------------------------------------------------------
---IRKGAAKLEEGCII

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIKKGFQLRKTAKTKTEADSCPKPVSSETTGTDGTDVK
HV---DHV--------------GILPQIKLDSSLNLDGTEQHKSKSKDNCGENFDNKPVV
IAPINLDTSACLMNISEQNAKLPVSALQ-EGANLK-----QNPDTFVK-EQSAIVTTESS
THNNIDGSSVDKCTL------GQSQWPSEISDEVDSKY----HEMPMQVEHKERAVEGKC
SLPKPSVLGTESSSNQNN-------ALNEGSQQHHNNTAN------ESLQQAQNSALSEA
SQQS-----CC---HTGIKGSPQFQSSALNADSQPSHTSVVGSAQAQRNELDDVALQTRD
TTVTEGSQVEEDKCNDEG--YPEHKTMGEHPLNSSSHSTTLQQSSEDGQ---KVKRGSSK
HKK-KRRSSKHGE-EDGVD-SPTHK-----------------TRGCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDTDPTE
ANLESADPELCARLLQVPSVVNYS

PF06371 // ENSGT00760000118986_1_Domain_0 (85, 187)

GLRKRLESSDGSWMVQFLEHSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSPQGMEYILGNPAYARQLSRAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

EGHALTLDALDHYKSTCSQQYRFSVIMSELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFVGLQLLDIL-TRLRDLEDPDLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------NSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-YLEPTRRSSQ---------------LLWEAL-ESLVNRAVLLASDAQD-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------DKAHKSIQ--ANLGQSQ---RGSSPENS------------------TAPKASV
EG----HQP-------AVAHTCQHV------GSVQSTSGGTASQLKALEQQAPTPPPPAP
PL-PSS--MPE-------------------------------------PPPP-PPPPPLP
SLGA--------------------------MSLPPPPPPPPLPSVGV-------------
--------TSPP------PPPP---LPGFHEIL-----PSPPPPLPGMGC--------PP
PPPLPGMGWGPPPPP----------------PLP---GPP---------AFGNVEEV---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSGHS--AEAVEPDF-------SSIERLFSLPVAKPKEPTVAS
APARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEITTMIQAGDTTKFDVEVL----KQLF
KLLPEKHEIENLRAFTEERARLANADQFYLLLLDIPCYQLRVECMLLCEGSAVVLDTVRP
RAQLVLAACKSLLTSHQLP----VF-CQLILKIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSYPDLLQLPQDLEQPSQAAGINLETIRSEASSNLKKLL
ETEQKVSASVPEVQEQYAKKLQA--SIVASRELDELFKAIEQKRQELADYL--CE-EAQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKERKDQAARAERRKQQLAEE-EARRPQGEA
---GKL------------------------------------------------------
---GRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRMDTDGGNK-ATTPDPLRVTEPAA
SR---DPAG---------GPRDSTCCSLS---QPGLDAAA-------TSKPQSWDLVDAM
TSSPQP----------------TQEPSEEGSPRPL-----ERRSSWYE-DASDFLAPQDT
-----Q-----CPLT------SEGAWPVTLG---------------------N------A
QALKHLKFSSNDQ---PP-------KAQGSSHDTKGTTSS------GSIHQAAADSTSQG
LEDT-----GI---HGHSAGLPA--------------TSL--------------------
----GGDADEEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPR--AWGR----STKGPGR
RRK-KRPTRSQE--EVVPD-TDDSKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHTLTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRIRTQLRCEFIGLQLLDIL-TRF-DLEDADLLIQLEA--FEEAKAEDE
EELLRMYDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPSGRTGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLAGKGRPRRGPL--
-------DQAHKSVQ--ADLDESQ---KDKPPHSI------------------TAPVTGM
GA----PQQ-------AVAPVCQQM------ASAWSSSM-TATQPPAPLQRAPSPPAPAP
-PLPG----PTTQ--PPLQPLPGL-----G-AMPPSL-------L---PPPP-PPPPPLP
SLGAKSPP-------------------------------------------VPPPA----
PPLPGF-----------------------GGAL----PPPPPPPLPSLGGSFST-PPP--
APPLPGFGGALPPPPPPPLPVTGCPP---PPPLPSTMGLP---------MAAGMEEI---
----------IVVQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SHVAREHNSM----WATLSSPG--SEQVEPDF-------GSIERLFSFPTVKPKELT-A-
APARKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEVTAMIRAGNTAKFDVEVL----KQLL
RLLPENHEIENLRAFTEERAKLASADQFYVLLLDIPCYQLRIECMQLYEGTAVVLDMVRP
KAQLVLSACESLLRSHRLP----IF-CHLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSYPDLLQLPRDLEQPSQAAGINVEIIRSEASANLKKLL
DAERKVSASTSEVQEQYKDRLQA--SIEASQELDAVFDTIEQRRLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCSL--KENKDRKEHVAKAERRKRQLAEE-AAQRPQGKD
---GKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGEAEGSGK-LTPAEPLGTREPAA
AS----DPT-------QGPEG-GTGSPAL---EQDLHAAV-------VSEPQGWDFVDTV
IPHPLP--------------H-----DEGSGPLPL-----ERRSSWYV-DASDFLDTEDA
-----L-----NACP------SKEPWPVALG---------------------D------S
HILKPLQFSSEVS---PG-------PQSPGLQDSEGCEAP------QGVHQAEADSTSQG
LED---------------------------------------------------------
-TGPGGDEDKEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--AQ----ALKGSSK
RRK-KRPTRSQE--EVAPE-SDDNKT----------------KRLCAIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQAYVRQLSLGL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSL

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 263)

EGHMLTLDALDHYKTVCNQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRGEFTGDRPRPPE-APL--------CLCLCCPLADPAHALPS
RTPGEVSGGSKPRARAERKAGAGASGPGWELTRAAQGHSPHCPFPGLQLLDILTRLRTRG
LAAAPRDRACQ---------------VWWCL-----------------------------
-------------------------------------------GAHVAVKPHPGPHEMPR
GARPAARGAAHRPGQ-GERQVQ--------GPVHA------------------AAPTAQA
GR----PAP-------HR----GQS------GPLHVVWVLPSQHPCMLGSCQPA-----P
-PDSGR--VPSTALPGSSARVPGW-----G-AAGGAQP----------QLVP-PTPP--Q
GPGGRRPADPA--GVPQGEPGPVSRPGSEAVT-----------------PADPPRP----
GSCRGRGAASGPAG-PSWLAPP---VPQSQGAR----------------------VPEGR
PGQRPGMLGGVPP------RTGQRPA---RPPLEGTSGSS-------------AEEI---
----------IVPHRDPGLGSAWVPNHRGGNP

PF02181 // ENSGT00760000118986_1_Domain_3 (873, 1281)

SS----------VPMKNVNWDK----LP
SNVAQEHSSM----WASLSCPG--ALVLEPDF-------CSIERLFCFPEAKAKERA-A-
AAARKEPKEVTFLDSKKSLHLNIFLKQFKCSNEDVAAMIQAGDTSKFDVEVL----KQLL
KLLPEKHEIENLRSFTEERTKLANADQFYLLLLAIPCYQLRVECMLLCEGTAVVLDMVQP
KAQLVLAACNSLLNSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKIQTLLKLTET
KS---QQSRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSESSSNLKKLL
EMERKVSSSVPEVQEQYSQRLQT--IIKASRALDEVFQAIEQKKLELASYL--CE-DAQQ
LSLEDMFG----IMKTFRDLFIRAL--KENKERKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRRGVGKQEEVCVIDALLADIRKGFQLRKTARGRGDAEGGSK-AAAADPPRDRAPAA
AR---GPA---------------------------GGGGP-------TSDPRGLDLADAV
APSPQP----------------AVDAPEDGGPGPQ-----ERRSSWYT-DASEFLAPEDP
-----Q-----GPPP------PQGAWPVVLG---------------------G------A
QALKPLRISGDKP---SG-------A-----QDAEEPTAP------RGVCLAEADSTVRA
PQEA-----AA---RGRSADPPA--------------TGPVGDG----------------
-DR---DGDQEDTAPDSALDTSLDRSFSEDAVTDSSGSGTLPSAR--GQ----ASKRMGR
RRK-KRPSRSQE-AEVVPD-PDDNKT----------------KRSCVIQ-----------
-----------

MRSQGSVRSSPGQGPEWVGRGGRKVLRIWLGK-MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

DSDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 336)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCVRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 406)

EGHALTLDALDHYKTVCSQQYRFSIIMNELSDSDNVPYVVTLLS------
AINAIILAPEDLRTRTQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKVEDE
EELLRVCDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPSGRSGQ---------------LLWEAL-ESLVNRAVLLSSDGEWWASRRYS-PWG
SHFPGPRGRPPNRAFLPTPSLPLPWPEKPRHVTAQACTLEEVVERP-----------L--
-------DRVHKSSH------------RDTAPKTT-------------------------
--------------------------------TVPGSSCVTAAQPMAPQQRAPGLPPPAP
-PLLG----PTTG--PPLHPMPGL-----G-AT---------------------------
-----S------------------------------------------------------
----------VPVP-PP-P---------------------PPPPLPR--C------PLPP
PPPPTGVGWGPG-----------------------ISGLP---------LAAGVEEI---
----------IVAQVDHGLGSTWVPSHRC

PF02181 // ENSGT00760000118986_1_Domain_3 (870, 1281)

VNPPT----------LRMKKLNWQK----LP
SNVAQERNSM----WATLSGLG--TQQVDLDF-------SSIERLFSFPTTKPREPT-A-
TPARKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEVTAMIRAGDTAKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADQFYVLLLDIPCYQLRIECMLLCEGTAVVLDMVRP
KAQLVLSACEGLLTSHRLP----VF-CQLILKIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPADLEQPSQAAGINVEIILTEASTNLKKLL
DTERKVSASVPEVQEQYQQRLQA--SIMASEELNIVFEAIEQKKLELADYL--CE-DPQK
LSLEDTFS----TMRTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTSAL--KENKDRKEQVEKAERRKRQLAEE-EARRPRGED
---GKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDSEGVTCI----SP-----PTA
AA---SDPA-------QGPA-GGTSCLAP---DLDHHTTV-------ASAPQGWDLVDAV
TPSPVP--------------P-----GRESSLPPL-----ERRSSWYV-DASDFLDTEDA
-----L-----NACP------SKKACPVALG---------------------D------S
QALKPLQFSIEEP---PG-------SKSLGPQDHEDPAAS------QGVHQAKADSTSLG
PED---------------------------------------------------------
-IGPSGEEDREDMAPESALDTSLDKS-SEDAVTDSSGSGTLPRAQ--DR----ASKGSSR
RRK-KRPSRSQE--EVAPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 276)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VVNAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLENADPELCIRLLQMPSVVNYSGLHKRLESSDGGWMVQFLEQSGLDLLLTALARLSGR
GVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSLAL--DTSNMMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 406)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VVNAIILGPEALRTRTQLRGEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEARAEDE
EELQRSCGGLDM--------------SSHQEVFASLFHKVSCSPASAQLLSMLQGLL---
-HLEPTRPPGQ---------------LLWEAL-ESLVNRAVLLAGDAQE-----------
------------------------------------SPLEEVVERLLSLKGRPRPSPQ--
-------DKAHKSVQ--ANLGPSP---GDVTALEG------------------PHA----
RP---ALRP-------AV-APCRRL------GGTFT-----------------SIPL---
-----------------------------------PPPFL-PGCR---QALP-PPPPPFP
GTGPLPPPPPPFPGTGPLPPPPPPLPGTGP------------------------------
------------------------------------------------------LPPP--
PPPLPGVGGPPLP---PPLPS----------------ASS---------LAGGVEDV---
----------IVAQVDHSLGSAWVPSHLR

PF02181 // ENSGT00760000118986_1_Domain_3 (870, 1278)

VKAPT----------LRMKKLNWQK----LP
SNVAREHNSM----WATLSGPG--TEVVEPDF-------SSIERLFCFPVAKPKEPS-A-
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTALLRAGDTTRFDVEIL----KQLL
KLLPEKHEMENLRAFTEERARLASADQFYLLLLDIPCYQLRVECMLLCEGTAVILDMVRP
KAQLVLAAC--LLTSHRLP----IF-CQLILKIGNFLNYGSHTGNAEGFKISTLLKLTET
KS---QQSRVTLLHHVLEVGHTGTPPGLSL------TLVPFRINLEIIRSEASANLKKLL
ETERKVTASVPEVQEQYTERLKA--SIAASRALDAVFQAIEQKKLALADYL--CE-EPLQ
LSLEDTFC----TMKAF

ENSGT00760000118986_1_Linker_3_4 (1278, 1398)

QDLFTRAL--KENKDRKEQLAKAERRRRQQAEG-EARRPKGED
---GKP------------------------------------------------------
---VRKGLGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1414)

DALLADIRKGFQLRKTTRGGGDSESSSR-GPAADPPRATEPA-
----------------------STGCAAV---EPGPGATA-------AAEPKGWDLVDAV
SP------------------------GQDDGPPAL-----ERQSSWYV-DASEVLIPEDA
-----L-----SLQP------PQGAWPVTLG---------------------D------S
QALQPIQFSDTAP---SA-------Q--GAPQDAEQRADS------PSVHQAEAHSMSGG
PADA-----AA---HGPGPC---------------------RAS----------------
-PSPRGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GR----TSKGTSK
RRK-KRPSRSQE--EVVPD-SDDSKT----------------KRLCAVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VVNAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGIDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPNLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGNSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPA------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPPTP-LLPGSSAEPPPPPPPP---
-----------------------------------PX-----------------------
-----------X-------------------------XXXLSPPLTSSCKF-----LPPP
PPPLPGMGCLPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCRPPV----VGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPVAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIQAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPTS---KPDFDATM-------ASEPRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSGNKS-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----PEDAV----HSCGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 406)

EGHALTLDALDHYKMVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINALILGPEDLRTRAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRVSDGINM--------------NSHQEVFTSLFHKVSCSQRRPAACQLLQGLM---
-ALEPAPRSGQ---------------LLWEAL-ENLVNRAVLLASDAEA-----------
------------------------------------CTLEE-VERLLSIKGRPRQAP---
-------DKAHKSVP-DTTLGQNQ---R-HSLQNL------------------PFPQVKW
KA---GR---------VVASPCQCG-------II-QAPHDAAPQLAAS------------
------------------------------------PCLP-TLSN---SPLA-PPPPPLP
GSGAHLPQHLL-------TPPCAPLPGSTMSPPPPPPPPAPLAALGPYLPSPPPRT----
PPLPGSGLCLPPAP-PP-S------LPHSTPA------HLPPPPLPGGMCP----VPP--
PPPLPTAGQ--------------VPP---PPPLPGFSVPS---------VVGGVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSL----WRKHDACSCTATVVKPD--------LSIEQLFSLPHPR--EP---S
APDRKEPKEGTFSDSKKSLNLN-FLKQFNGSNEEVTGMIQAGDTSKFDVEVL----KQLL
KLLPEKHEIENLRAFTEDRAKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRP
KAQLVLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLSRDLESPSQAAGIHLEIIHSEASANLKKLL
EAERKVSSSIPEVQKQYAERLQA--SIEASRALDKVFDAIEQKKLELADYL--CE-DPQK
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAEKRKQQLAEE-EARRPRDED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEASGR-VAPADPPKITEPAT
AS---NP-------------TQGTNQPAS---EPSSDTTA-------AGEPQGWDLVDAV
TPSPQP--------------T-----KEDGGPPSL-----ERRSSWYV-DASDFLAPEDI
-----L-----NTQP------SEGAWPVTLG---------------------D------D
QALKPLEFSSNKP---PG-------VERSH-QDATDPEAL------WGVHRAEADSTSVR
PEDA-----TE---RGQGTHLPR--------------P----------------------
----GEDEDEEDTALESALDTSLDRSFSEDAVTDSSGSGTLPRVQ--GR----ISKGTGK
RRK-KRPSRRQE-AEFAPD-SDDNKA----------------KRLCVIQ-----------
-----------

--------------------------------MSIKKEGAHKKWAALKEKLGPQETDQSE
ANLENAEPELCIRLLQMPSVVNYSGLKKRLENSDDAWMVQFLELCGLDLLLEALDRLSGR
GVARIS

PF06371 // ENSGT00760000118986_1_Domain_0 (127, 188)

DALLQLTCINCVRAVMNSHKGIEYIVSNEGYVRKLFQAL--DTTNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSS

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

DGHTLALDALDHYKSVKNQQYRFSVIMNELSNTDNVPYMVTLLS------
AINAIILGKEDLRTRTQIRNEFIGLQLLDIL-DKLRDIEEEDLLIQCDT--FEEFKIEDD
EELLKICDGINM--------------NDHHEVFSSLFNKVSRSPVSIQLLSILQSLL---
-HLEPSHHSNL---------------LLWESL-DAVVNRALLLANDIQG-----------
------------------------------------NTVEEVIERLL

ENSGT00760000118986_1_Linker_1_2 (468, 560)

SVKKQPNKQKR--
-------AENRLSGNA-NRGIHTEVEL---------EPCASA--VQS--LVGSANPS-KA
PAPPSGPPANEEKISSCQL

PF06346 // ENSGT00760000118986_1_Domain_2 (560, 833)

SACS-------------ALPQTSNPPPNAAPAPPPPP----
---------------PPPPPLPSG---M-AAVPPTSPMM--NTPPAPPLPGIPPPPV--P
NMGG---------------------------IPPPPPPLP---GLGG-----ISPP----
PP-----------------------LPVIGG------IPPPPPPLPGMGGI-----PPPP
--PLPGMGGIPPPP-PL--PCIGGIPP-PPP-LPGMGGIPTCKAKFILQPSS

ENSGT00760000118986_1_Linker_2_3 (833, 867)

GDLVL---
----------ITRAFSCWDYF-SKDF

PF02181 // ENSGT00760000118986_1_Domain_3 (867, 1282)

YSQVQKKK----------KMFKKVQWGL----IQ
PALTQESHSM----WASVSSSS--EETIEPNY-------TSIEQLFCFPQPTPKEKTA--
APVKAEPKEITFLDSKKSLNLNIFLKQFKCSNEEVAAMVQNGDRTKFDVEVL----KQLL
KLLPEKHEIENLKAFKEEKSKLANADQFYLLLLKIPSYQLRIECMLICEETTVVLDMIQP
KAGAIRRACEDLLNSHRLP----LF-CQLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEEVENSHTDLLELPEDLEYVSKAAGINLDIIRSESSTNLKKLL
ELQRKVSSSNDDVKQQYEKPIQD--SIDAARKLEEEFETIDRKREELANYL--CE-DPSK
LSLEDIFN----TMKTFRDLF

ENSGT00760000118986_1_Linker_3_4 (1282, 1398)

IRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRQKGEN
---GKV------------------------------------------------------
---IKKGVVKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFTLRKTKN-RHESDAPPK-TLPVESPEENQAGK
-----D------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRARTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLDQSQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHAQSESILKVS---QP------------
----------------RALEQQAS-----TP--PPPPPPP-LLPGSSAEPPPPPPPPPLP
SVGA--------------KA--------L--PTAPPPP---------------PLP----
-G---LGAMAPP-------------------------APPLPPPLPGSCEF-----LPPP
PPPLPGLGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCSPPV----AGGMEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVEPDF-------SSIERLFSFPAAKPKEPTMVA
PRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-AASMDPPRATEP--
--VATSNPAGD--------PVGSTRCPAS---EPGLDATT-------ASESRGWDLVDAV
TPGPQPTLEQL----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------P----AAGSSRQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
-----------------------SR

PF06371 // ENSGT00760000118986_1_Domain_0 (146, 188)

QGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 305)

EGHTLTLDALDHYKAVHSQQYRFSVIMSELANSDNVPYVVTLLS------
VINALILGPEDLRTRSQLRNEFVGNCLAHPA-LLLRDTEDADLLIQLEA--FEESKAEDE
EELLRAGGGVDM--------------SSHQEVFASLFHKVGLGGCRLKSRAQQQPLL---
-CPADLHHNQGSSASFMAQSLEQQGMGGWTEC-SPELSGG--------------------
------------------------------------WAVPRTG-------EQCSSGRR--
-------QPHWSEGQS-ALGISRLSEKPEAKFKSSSSPCFTDRMIQTLCIQKPWFYLSEP
PLCHQGSLEAQECVGGAGRGSAFRA------GGGRGQAPWAGLGGPR----RRTPP--WS
APLK---------DPPVLRVLPDKPSCACAYLPSWAPST--PAPPRLSPRNL--PPLLLS
SFRS--------------TPS--RSAGSPRTLGPADPALSSR-RVGA-----VTKKSHDG
TARPQVGVARAPQGWCSL----TGNVVLGGG------AEPPGPPAAAP--------GPRA
--GLPG-------------GGVGAGPA-PTALLPHPPRLGL-------------RAA---
----------A-------------------QPRP----------MEPLPSDMHT----FP
VGLTEGRPST----WGGRLTTL--LTNIS-------------------------------
------------------------------------------------------------
---PHR------------------------------------------------------
--NPVRR--------------------RHAWWVGR--GYRASGGPSRAFGVTILSLIDST
LS---EALKAHSHHRSLMYFLQACGHVLRGSPGL-----PWVINLEVIRSEASANLKKLL
ETERKVLASIPEVQEQYAERLQT--SIEACRLLDEVFAAIEQKKLELASYL--CE-DTQQ
LSLEDTFC----TMKTFRDLFLRAL--KENKDRKEQAAKAERRKKQLAEE-EAQRPRGED
---GKP------------------------------------------------------
---VRRGAGQQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARSRADMEGGSK-AVADSARDRKPAAT
----SSPREGP-------------THPAS---ELDLASAV-------ASEPRAWDLMDAT
LPHPQ-PSAET----------G--------SPGPLERRSS-----WYM-DASDSLATEDP
-----Q-----NPQP------SAGPWPVALG---------------------D------A
QAPKPLKFSSDKL-------LS-TAD---SGQGTREP------TTLQGACQADANAFTPS
T-------------------------------------S-------------------LL
PAGSIGGGDEEDVAPESALDTSLDRSFSEEAVTDSSGSGSLPKAR--SA------KGTGR
RRK-KRPSR--NQEEIAPD-SDDDKT----------------ERFCVLQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDSDPTE
ANLESAEPELCIRLLQVPSVVNYSGLRKRLESSDGG

PF06371 // ENSGT00760000118986_1_Domain_0 (97, 188)

WMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQEGIQYILSNQAYVRQLSQ--------VMVKKQVLE
LLAALCVYSPEGHALTLDALDHYKTVCSQXXXXX---X---XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXLQLLDVL-MRLRDLEDEDLLIQLEA--FREAKAEDE
EELLRVFGGVDV--------------SSHQEVFASLFHKVSCSPVSAHLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDXXX-----------
------------------------------------XXXXXXXXXXXXXXXXXXXXXX--
---------XXXXXX--XXXXXXX---XXXXXXXXXXXX----------XXXXX------
---XXXXXX-------XXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XPLPGT----------------------------------------ATCPPPP-------
-----PPP----------PPPPPPLPSLGAAFPSP-------------------PP----
PPLPGPSGTI----------------------------PPP-PPPPGLGC--------PP
PP----------------------------PPLPGTSGPP---------AAGGMEEI---
----------T---VAHSLGSAWVPSH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1222)

RRVQPPT----------LRMKKLNWQK----LP
SSVARERSSM----WASLSSPD--TEMVEPDF-------STIERLFSFPVAKPKEQA--V
APARKEPKEITFLDSKKSLNLNIFLKQFRCSNEEVTAMIRAGDTTKFDVEVL----KQLR
KLLPEKHEDEHLRSFTEDRARLASADQLYLLLLDIPCYQLRVECMLLCEGTAVVLDMVRP
KAQLLLAACEGLLASHRLP----VF-CLLILKIGNFLNYGSHTGDADGFKMSALLKLTET
KA---QQGRVTLLHHVLEEVEESHPDLLQLPQDLEPPSRAAGINLEIIQSECSSNLKKLL
EMERKVSSSIPEVQEQYSQRLQX--XXXXXXXXXXXXXXXXXXXXXXXXXX--XX-XXXX
XXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXX----------XXXXXXXXXXXX
X--XXX------------------------------------------------------
---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX
XX---XXXXXXA----TRDPVGGTSLPTS---EPGLDAAV-------AKEPRGWGLADAA
PSSPQP----------------TGDSSEKGGPGPL-----ERRSSWYM-DASDVLATDDP
-----L-----GPQP------S-----LVLG---------------------G------T
QALKPLNFSSDKL---SK-------ATGLS-QDTEEPTAP------PGARQAEADTTGEG
AEDA-----AA---HGRGAGLPA--------------AGR--------------------
--GGDGDEDDEHTAPDSALDTSLDRSFSEEAVTDSSGSGALPRAQ--GR----TSKGTGK
RRK-KRPSRSQE--EVALD-PDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGARRKWAALKEKLGPQDSDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGG

PF06371 // ENSGT00760000118986_1_Domain_0 (97, 188)

WMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQAYVRQLSLAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

EGHVLTLDALDHYKTVRSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLHTRTQLRGESPRLQLLDVL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLRTCGGVNM--------------NSHQDVFASVFHKVSCSPASSQLLSVLQGLL---
-YLDPILPSSQ---------------LLWEAL-ENLVHRAVLLASDVQE-----------
------------------------------------CTVEEMVERLLSVKGRPRPSSL--
-------NKAHKSVQ--ADLGQSR---KGSMPQNS------------------GAPKAGV
ED----QQP-------EADLTSLHI-------VDVQSSSSVXP-----------------
---------------------------------------------------P-PLP----
------------------------------------------------------------
------------------------------------------------------------
---------GPPP--PPPLPGPS--------------GSS---------TVGGEEEIIVA
HVTQGLGSXXIVSQVTHSLGSAGVPSH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1282)

RRVNPPT----------LRMKKLNWQK----LP
SNVAREHSSM----WASLSSLG--AEAVEPDF-------PSIERLFCFPEAKPKEHV-A-
APARKEPKEITFLDSKKSLNLNIFLKQFRCSNEDVTAMIRAGDATRFDVEVL----KQLL
KLLPEKHEIENLRSFTEDRAKLANADQFYLLLLGIPCYQLRVECMLLCEGTAVVLDMVQP
KARLVLAACNSLLTSHQLP----IF-CQLILKIGHPHSHPTHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPRDLEQPSHAAGINLELIRSECSTNLKKLL
EMERKVSSSIPEVQEQYTQRLQA--SIEASRALDEVFQAIEQKKLELASYL--CE-DAQQ
LSLEDMFS----TVKTFRDLF

ENSGT00760000118986_1_Linker_3_4 (1282, 1398)

IRAL--KENKDRKEQAVKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRRGVGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGSK-AAAMDPPKDKA-PA
A---------------------TRV-SAG---GTG---CP-------TSEPQG--LSDAT
AP--SP--------------QPTADPAE-GGPGSL-----ERRSSWYT-DASDVLTTEDP
-----Q-----SPQP------SQGAWPVLLG---------------------G------A
QALKPLMFSADKP---PG-------ATGSS-QDAEGPTAP------RGSCLAEADSTMEG
PQEA-----AT---HRRSANLPT--------------TGPVVAG----------------
-DGDG---DQEDTAPDSALDTSLDRSFSEDTLTDSSGSGTLPRAR--GQ----ASKRTGK
RRK-KRPSRSQE-AEVVPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAVILGPEDLRIRTQLRCEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVCDGVNM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPSGRSGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLAGKGRPRPSPL--
-------DQAHKSVQ--ADLDQNQ---RAMPPGDT------------------TAPRAGV
GG---AWQP-------AVAPACQRV------ASIQSSSVTTV-QPAAPPQRTPSPPPPVP
-LLPG----PTTR--PPLHPLPGL-----G-TTPPPPPLP-SLEA---TPPP-PPPPPLP
NLGATPPPPPPLPNLGATPPPPPPLPNLGATPP----PPPPLPNLGA----TPPPP----
PPLPSLGATSPPAP-PP-PPPP---PPLSLGAMP--PPPPPPPPLPSLGGSFSSAPPP--
APPLPGFGSALPP-PPPPLPGCPPPP---PPLLPGTLGLP---------MAAGVEEI---
----------IVAQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSGPG--TEQVEPDF-------PSIERLFSFPVAKPKEPT-A-
APARKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEVTAMIRAGDTAKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADQFYVLLLDIPCYQLRIECMLLCEGTAVVLDMVRP
KAQLVLSACDSLLNSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPRDLEQPSQAAGINVEIIRAEASTNLKKLL
DAERKLSTSAPEVQEQYKHRLQA--SITASQELDSVFKAIEQRKLELADYL--CE-DPQQ
LSLEDTFS----TMRTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCSL--KENKDRKEQVAKAERRKRQLAEE-EARRPQGKD
---GKP------------------------------------------------------
---GKKAAGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1414)

DALLADIRKGFQLRKTTRGRGEAEGSGR-LAVADPLRAREPAA
AS----DPV-------QGPTGGT-GCPAL---ELDLRAAV-------SSEPQGCDSLDTV
TPSPAP--------------C-----GEESGPPPV-----ERRSSWYV-DASDFLDTEDA
-----L-----STCP------SKEAWPVALG---------------------D------S
HTLKPLQFSSKEP---PG-------PQSSGPQDAEDPEAS----------QARADSTSQG
PED---------------------------------------------------------
-IGPGGDEDREDTAPESALDTSLDKSFSEDMVTDSSGSGSLPRTR--GQ----TSKGSSK
RRK-KRSSRSQE-GNLGPE-GWRGGLWCRPAVKAPIPAGLGTTPSCGHHLVTGPAPSPGG
TAGSSSGQERG

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPSTP-LLPGSSA------------
------------------------------------------------------------
----------------------------------------------DSCEF-----PPPP
PPPLPVMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLA-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVE----------
--------IENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPAS---KPDLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDSDP

PF06371 // ENSGT00760000118986_1_Domain_0 (59, 187)

TE
ANLESADPELCTRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSQQGIEYILSNQAYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 467)

EGHGLTLDALDHYKTVRSQQYRFSVIMNELSDTDNVPYVVTLLS------
VVNAIILGPEDLRTRTQLRGEFTGLQLLDVL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVCGGVNM--------------TSHQEVFESLFHKVSCSPASARLLSVLQGLL---
-YLEPTLPSSQ---------------LLWEAL-ENLVNRAVLLASDVQE-----------
------------------------------------CTLEEMVERLLSVKGRPRPSSL--
-------NKAHKSVQ--ADLGQSR---KDSAPQNS------------------GSLKADV
EE----QQP-------EAGLSGLHL-------TVQRANGSVAP-----QLQKPTPVPP--
-----------------------------------APPLP-GSSS---AGPP-PPPPPPP
----------------------------------------------P----LPPTP----
LPVLGAQASPPPPP-PS-PPPP---LPVSGGAPP--PPPPPPPPLPVLGC------PP--
PPPLPGLDGGLPT--PPPPPGPS--------------GAS---------PVGGEETIVA-
-------------HTISAQGSAPVPSHRRVL

PF02181 // ENSGT00760000118986_1_Domain_3 (872, 1281)

APS----------LRMKKLNWQK----LP
SNVAREQSSM----WASLSSLG--AEVVEPDF-------SSIERLFCFPEAKPKERM-A-
APARKEPKEITFLDSKKSLNLNIFLKQFKCSNEDVTAMIRAGDTTKFDVEVL----KQFL
KLLPEKHEMENLHSFTEDRAKLANADQFYLLLLGIPCYQLRVECMLLCEGAAVVLDMVQP
KAQLVLAACCSLLTSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEAEKGHPDLLQLPRDLEQPSQAAGINLELIRSESSTNLKKLL
EMERKVSSSIPEVQEQYAGRLQA--SIEASRALDEVFQAIEEKKLELARYL--CE-DAQR
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FVRAL--KDNKDWKEQAVKAERRKRQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRRGVGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGGK-AAATDPPRDKA-PA
CP---QLPC-------PVSTAATRV-PAE---GTG---GP-------ASEPQSWDLSDAT
AP--GP--------------QPIADPPQGNGPGSL-----ERRSSCYI-DASDVLTTEDP
-----Q-----NPQP------CQGAWPVVLG---------------------S------A
QALKPLRLSGDKP---PG-------ATGSG-QDAEDPTAP------RGVRRAEADSTVEG
TQE---------------ADLPA--------------TGPGVAA----------------
-DGEG---DQEDTAPDSALDTSLDRSFSEDTVTDSSGSGTLPRTR--GQ----ASKRMGK
RRK-KRPSRNQE-AEVVPD-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWVALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRRLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNAPYVVTLLS------
AVNAIILGPADLRTRTQLRSEFIGLQLLDVL-NRLRDLEDADLLIQLEA--FEEARVEDE
EELLHVCDGINM--------------NSHQEVFTSLFHKVSCSPASAQLLSVLQGLL---
-HLEPSGSSGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLAAKGRPRPSPQ--
-------DRAHKSVQ--ADLDRSQ---RDRPPKTI------------------APGAVD-
-----TPQP-------AXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXXX-X
---XX-----XXX----------------------XXXXX-XXXX---XXX--XXX---X
-XXXXXXX--------------------------------------X----X--XX----
--X-XX------XX-X---------XXXXXXXXXXXXXXXXXXXXXXXGCP-----PSPS
PAPWSGLG--PRH-------------------------LW---------APHGS------
-------RPVIVAQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAQEQNSM----WATLSGPG--TQQVELDF-------SSIERLFSFPTAKPKECT-T-
APTRKEPKEVTFLDPKKSLNLNIFLKQFKRSNEEVTAMIRAGDTAMFDVEVL----KQLL
KLLPEKHEIENLRTFTEDRAKLASADQFYVLLLDVPCYQLRIECMLLCEGTAVMLDMVRP
KAQLVLNACERLLTSHRLP----IF-CQLILKIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLAGDLEQPSQAAGINVEIIRTEASANLKKLL
DTERKVSASVPEVQEQYKQRLQA--SITTCQELNSVFEAIEQKKLELADYL--CE-DPQK
LSLEDTFS----TMRTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCAL--KENKDRKEQVEKAVRRKQQLAEE-EARRPQGGD
---RKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGLSK-VAAVDPVRPREPAA
AS---DT-A-------QGP-AGGTGCPAP---DLDLRVTV-------TSEPQGWDLGDAV
SRSPVP--------------P-----GEESGLPRL-----ERRSSWYV-DARDFLDAEDA
-----L-----NVCP------SKEACPVALG---------------------D------S
QALKPLQFSIEKP---LG-------SQSSGPQDHENPKAS------QGVHQAKADSTSLA
PED---------------------------------------------------------
-IGPSGDEDREDTAPESALDTSLDKS-SEHAVTDSSGSGTLPRAQAWGR----ASKGSSR
RRK-KHPSRSQE--ELAPG-SDDNKT----------------KRLCVVQ-----------
-----------

---------------------------------MSGKEGVQKKWAALKEKLGPQDGDP

PF06371 // ENSGT00760000118986_1_Domain_0 (59, 186)

TE
ANLENAEPELCIRLLQMPSVVNYSGLRKRLESSDDGWLVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGIEYILSNQGYVCKLSEAL--DTSNVMVKKQVFE
LLAAL

ENSGT00760000118986_1_Linker_0_1 (186, 191)

SIYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 467)

EGHKQTLDALDHYKVVKSQQYRFSVIMNELSSTDNVPYIITLLS------
VINAIILGTEELRARTQLRNEFIGLQLLDIL-TKLRDIEDLDLLIQCET--FEEAKSEDD
EELLRIFDGIDM--------------SSHQEVFSTLFNKVSCSPISVQLLSVLQGLL---
-HLEPAQHSSL---------------LLWEAL-EILVNRAVLLASDVQE-----------
------------------------------------SSIEEIVERL

ENSGT00760000118986_1_Linker_1_2 (467, 654)

LSMKMRPQQSPKIC
N----LVKTAHKCIQ--TNLDRA-----GSSPKGSQKEK-------------GARPLSDN
GT----LET-------VTAFQMQTAS---ATPELHTSTPDPAVVPHVGKTSI--PPPPPP
PP------------------LPSF-----LWAPPPATPMS-SKTSVPSPPPP-

PF06346 // ENSGT00760000118986_1_Domain_2 (654, 851)

PPPPPLP
GMTRT----------PSTTPPCPPLPGVGGIPPPPP-----LPGLGG-----IPPP----
PPLPGLGGIP--------PPPP---LPGLGS-------IPPPPPLPGLGGI-------PP
PPPLPGLGGIPPP---PPLTGMACVPP-PPPPLYGEIPPP---------PMNGTEEI---
----------

ENSGT00760000118986_1_Linker_2_3 (851, 868)

IVAHVDHGLGLVRVPNH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1281)

RKVNPPT----------LRMKKLNWQK----LP
SNVVRDSHSM----WASVSSLS--NETMEPDY-------SSIEQRFCFPITKPKEKE--A
APVKKEPKEITFLDAKKSLNLNIFLKQFKCPNEEITDMIRRGDRTRFDVEVL----KQLL
KLLPEKHEMENLKSFQEEKAKLASADQFYLLLLNVPSYQLRIECMLLCEETVIILDMIKP
KAEVIRKACESLLTSQRLP----IF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQSRVTLLHHILEEVEKNYPDLLQLPNDLEHISRAAGINIDVIHSEASTNLKQLL
EMERKVSSGIPEVQEQYVKPLQD--SISASRELEEEFKVIERQKIKLADYL--CE-DAHK
LSLEDTFS----TMKTFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKDWKEQAVKAEKRKKQLEAE-EAKRPRGED
---GKI------------------------------------------------------
---IRKGAVKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTAKGKADSENGLKAAPP-ETSKEKE--A
VI---KD-----------------------------TGSS-------TNSGQDFDLAAAI
GETSDQ--------------DNPDGPGSTGGIPKG-----H----SEV-SGSGCRNPEGN
-----KVSTP-MAGF------PDDPHM-------------------IQFD--D------S
KSLKPIKFSSGSF---SG-------GTNMGSEVDA-TRTG------DQASEHQADRTSEG
PKNG-----FQ---RSEEAES----------------TP---------------------
-PEGEEEEEEEDTAPDSVLDTSLDRSFSEEAITDSSGSGTLPRSQ--ER----TKKGSGK
RRK-KRHSRSHE--EVDSD-SGDVKT----------------KWPCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDADPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSQQGLEYILSNQAYVRQLSL--------XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXLQLLDIL-TRLRNLEDADLLIQLEA--FEEAKAEDQ
EELLQLCGGVDM--------------NSHQEVFASLFHKVSCSPASAQLLSMLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEMVQRLAVVKGGPPSSPD--
---------KHKAVQ--ANLGQRR---RGSSPQNSG--T----------P-EAG------
---VKAQQP-------AVTLTSLHA-------VNKQSGSPKAPEPRALELRAPTPPPPLP
PPLPGP-----------------------GP---------------SARPPLPPPPPPLP
GPGASFPP----------PPPPPPLPGPGASFPPPP------------------PP----
PPLPGPSGTL----------------------------PPLPPPLPGMGC--------PP
PPPPPIMGWGPPP----------------PPPPPGTSGAP---------TVGSMEEV---
----------IVAQVDHSLGSAWVPCH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1282)

RRVKPPA----------VRMKKLNWQK----LP
SNVAQERSSM----WASLSGLG--PEVVEPDF-------SSIERLFSFPVAKPKEPA--A
APARKEPREITFLDSKKSLNLNIFLKQFKCSNEEVAAMIRSGDTTKFDVEVL----KQLL
KLLPEKHEIENLRSFTGDQAKLASADQFYLLLLGIPCYQLRVECMQLCEGTAVVLDMVRP
KAQLVLTACNSLLTSHQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEAQKSHPDLLQLPQELEQPSQAAGVNLEIIHSEASTNLKKLL
EMERKVSS-APEVQQQYAQRLQA--SIEASQALEEVFQAIEQKKLELAHYL--CE-DAQQ
LSLEDTFS----TMKTFRDLFIRA-L-KENRDRQEQ-A----------AKAEARRLRGED
---GKP------------------------------------------------------
---XXXXXX-XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXX
XX---XXVSSDP----TGGPVGGTSCPAS---GPGLDTEV-------AREPLTWDLVDAT
VPSPEP----------------TGDVSEEDELRPQ-----GRRSSWYI-DASDVLPSADP
-----Q-----SPQP------PVGSWPVALG---------------------D------A
QALKPLHFSSDKP---PG-------AMGSG-HDTEDPVAP------RGVCQAEDDSADEG
AEDT-----AV---PSRS------------------------------------------
----AGDRDEEDTAPDSALDTSLDRSFSEDSVTDSPGSGTLPRAR--GR----ASKGTGR
RRK-KHPSRSQE--EVAPD-SDDNKT----------------KRFCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQVPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQEGIQYILSNQAYVRQLSLAL--DTSNMMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 467)

EGHALTLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLS------
VVNAIILGPEDVRARAQLRSEFIGLQLLDVL-TRLRDLEDGDLLIQLEA--FREARAEDE
EELLRAFGGIDI--------------NSHQEVFSALFHKVSCSPASAHLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLATDGQE-----------
------------------------------------CTLEEMVERLLSIKGRPHPRSL--
-------DKAHKSTQ--ADFGQSQ---RGSSPQNS------------------GTPTADL
GG----QQP-------AAALGSPPV------ASVQGERG-PAPQPTAPEPLERPSCPSAP
CLLPGG--CSGHR--------------------VKAQRYP-VSSR-----AG-HLPTAVP
GMGARAPS-------------------------------------------LPPWA----
PSWPGP------RP-APWVWPW---ER---------------------------------
--RRAARCWRSRAP-PPRCRGCST--------LPTWSCPL---------WVRGLQSG---
------------SHLTPKSRGSWCRPRGLAGVPCLGPGPGQA--YSRHLINAQR----SP
PADAMSTPSP----WAHAVQGP-SSRDLPPSRGRVGAQGPEGRPLTCPRPLLQEESR---
-GGRASPRA--TLDG-NFCQFSFFMRR-------VGGFTRRWRGTQAEPRPPSTWATMIS
STLPAGPCGSQAG---------GWGPLEPELLLC

PF02181 // ENSGT00760000118986_1_Domain_3 (1055, 1281)

RPSYQLRIECMLLCEGTAVVLDMVRP
KAQLLLAACESLLTSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAIHSESSTNLKKLL
EMERKVSSSVPEVQEQYSHRLQA--SITDSQALEEVFQAFEQKQLELASYL--CE-DTQQ
LSLEDTLS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGEG
---GKA------------------------------------------------------
---ARRGGGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEAASR-AAATDPPRNKAPAA
TR---DP-------------VGGASPPTS---EPGLDAAA-------AREPQGWDLADAV
PTSRQP----------------TGDSSETGGPGAL-----ERRSSWYT-DASDFLPTEDP
-----Q-----GPQP------PAGAWPVVLG---------------------D------A
QALKPLDFSDQPP---KA-------MD-LS-PDAEEPPAT------LGARQAEASSADEG
LEDA-----AA---HCHRAGLPA--------------AGP--------------------
----DEDGDGELTAPDSALDTSLDRSFSEDAVTDSSGSSTLPRAQ--GR----TSKGTGK
RRK-KRSSRNQE-AEVAPD-PDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

ESDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSKQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGLQLLVTL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCDGVNM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPAGRPGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--ANLGQNR----GSSSKNT------------------TTPSAKW
EG----QQP-------V-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------PP--PPPLPGFS--------------VPS---------TMGGVEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSSPC--TEAVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APTRKEPKEVTFLDSKKSLNLNIFLKQFKSSNEEVTSMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERTKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRP
KAQLALTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLARDLEPPSQAAGINLEIIRSEASGNLKKLL
EIERKVSASIPEVQKQYAERLQA--SIEASRALDKVFEAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAEKRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEAGSR-VTPTDPPKATEPAT
AS---NA-------------IQSTNHPAS---EPSLDTTA-------AGEPQGWDLVDAV
TPSPQP--------------S-----KEEGGPPAL-----ERRSSWYV-DASDFLVPEDN
-----L-----NAQP------SEGIWPVTLG---------------------D------D
QALKPLEFSSNKP---PG-------VESS-PQNAVDPEAL------WGVRQAKADGTREG
PEDT-----AE---RGHSPHLPC--------------TGPGED-----------------
-------EDQDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVR--GR----VSKGTSK
RRK-KRPSRNQE--ECAPE-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQNGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQQGIQYILSTQAYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 340)

EGHALALDALDHYKMVCSRQYRFSVIMSELSDSSNVPYVVTLLS------
VINAIILGPEDLRARTQLRSEFIGLQLLDVL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVCGGIDM--------------NSHQEVFASLFHKVGWGQGSPSR-----------
----------D---------------CLWEEGLCGL-------------WPKS-------
------R--------ARKQPLSLPWSDHPMTWAVGP-DLE-LHSG--SREGSGRWSRQPG
AGLGYPRERARATGP-G-----------RTGFQRP------------------GCPEGAV
QS----WAP-------AEWPPSG---------RLRGASGPMRVQEAKVQS----------
---------------------------------STDPPWV-DLTY---SLNP-VA-----
-----------------------------------------------F------SQ----
ASVPGGSRLSGDVV-LSKDVSG---FSGWRSGIG--TAPPPPPPLPSVGCP---------
-------------PPPPPLPGTGPPP---PPPLPGTSGPP---------AAGGMEEV---
----------IVAQVDHRLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREGNSM----WASLSSLG--AEVVEPDF-------SSIEQLFSFPVAKPKEPA-A-
APARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIQAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRSFTEDRTKLASADQFYLLLLGIPCYQLRVECMLLCEGTAVVLDMVQP
KAQLVLAACESLLTGHQLP----IF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLPQDLEKPSQAAGINLEIIHSESSTNLQKLL
EMERKVSSSIPEVQEQYAQRLQARASIAASRALEEVFQAIEQKKLELASYL--CE-DAQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRDED
---GKP------------------------------------------------------
---VRKGGRKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGGR-AAAAEPRRDRAPVT
TS---DP-------------MGGTSCPPS---EPGLDTAV-------ATEPRGWDLVDAT
VPSPQP----------------TVDPPEEGGPRPL-----ERRSSWYV-DASDFLTLEEP
-----AGSEPPGSEP------SAGAWPVGLG---------------------D------A
QALKPLQFASDKP---PG-------AMGSS-QDTEDPTVS------RGTDQAEADSTGEG
PEDA-----AA---HGHSAGLPA--------------IVPGGD-----------------
-----GDEDEEDTAPDSALDTSLDKSFSEDVVTDSSGSGTLPRAR--GR----ASKGPGK
RRK-KRPTRGQD--EVAPD-SDDNKT----------------KRLCAIQ-----------
-----------

---------------------------------MSEKEGAQRKWAALKERLGPQDSDPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLESSDGL

PF06371 // ENSGT00760000118986_1_Domain_0 (97, 188)

WMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQQGLRYILSNQAYVRQLSQAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 263)

EGHELTLDALDHYKVVCNQQYRFSVIMSELSDSDNVPYVATLLS------
VVNAIILGPEDLHTRAQLRNEFIGLHLLDVV-TQL-------------------------
------------------------------------------------------------
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------------------------------------------INLDIIRTESGA

PF02181 // ENSGT00760000118986_1_Domain_3 (1195, 1281)

NLKKLL
ELQRKVLSSNEDVKQQYEKPIQD--SIDASRKLEEEFETIEKKREELANYL--CE-DPSK
LSLEDIFS----IMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRQKGEN
---GKV------------------------------------------------------
---IKKGLLKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFTLRKT---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

------------------------------------------------------------
---ENAEPELCIRLLQMPSVVNYSGLRKRLESSDDG

PF06371 // ENSGT00760000118986_1_Domain_0 (97, 188)

WLVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAIMNAHQGIEYILSNQGYVCKLSEAL--DTSNVMVKKQVFE
LLAALSI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 263)

EGHKQILDALDHYKVVKSQQYRFSVIMNELSSTDNVPYTITLLS------
VINAIILGTEELRARTQLRNEF

ENSGT00760000118986_1_Linker_1_2 (263, 616)

IXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXX
XXXXX--------------XXXXXXXXXXXXXXXXXXXXVSCSPISVQLLSVLQGLL---
-HLEPTHHSSL---------------LLWEALXXXX-XXXXXX-----------------
------------------------------XXXXQESSIEEIVERLLSMKMRPQQSRKIC
S----LVKTAHKCIQTS--LDHHQ---KSPKEDAS-------------------APR---
---------------------LVKA------IHLQAASA--T----------PKPRHPLQ
PQLPHSLSQP-ATSP

PF06346 // ENSGT00760000118986_1_Domain_2 (616, 833)

PPPPPLPNF-----SWAPPPATPMS-SKPM---SL----------
----------------LLAPPPPPLPGLGGIPPPPPPPPPPLPSLGG-------------
--------------------------------------IPPPPPLPGLGGI-------PP
PPPLPGLGGIPPP---PPLTGMGCVPP-----------PP---------PMN

ENSGT00760000118986_1_Linker_2_3 (833, 868)

GIEEI---
----------VVAQVNHGLGFARVPNH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1282)

RKVNPPT----------LRMKKLNWQK----LP
SNVVRDSHSM----WASVSSMS--SEDMEPDY-------TSIEQLFCFPTTKPKEKE--A
APVKKEPKEITFLDAKKSLNLNIFLKQFKCPNEEITDMIRRGDRTRFDVEVL----KQLL
KLLPEKHEIENLKSFQEEKTKLANADQFYLLLLSVPXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQSRVTLLHHILEEVEKNHPDLLQLPSDLEHISRAAGINIDAIHSEASTNLKQLL
EMERKVSSGIPEVQEQYAKPLQD--SISASRELEEEFKIIERKKVELADYL--CE-DAHK
LSLEDTFS----TMKTFRELFIRAM--KENKDWKEQAVKAQKRKKQLEDE-EAKRPRGED
---GKI------------------------------------------------------
---XXXXXXXXXXXXXXXXXXXXXX-----------------XXX---------------
XX---XX--------------------XX------XXXXX---------------X----
----XX--------------------XXXXXX-------------XX--X----------
----------------------XXXXXXTLD---------------------D------S
KSLKPIKFASGPP---LG-------AWTR--QDATR----------AEDQQSEAGRTAKT
PENG-----VR---GCRAP--P--------------------------------------
EVEEEEEEEEEDTAPDSVLDTSLDRSFSEGAITDSSGSGTLPRSQ--ER----TKKGSGK
RRK-KRHPRSHE--EVDSD-SGDDKT----------------KWHCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

ESDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSKQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRSEFIGLQLLVTL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCDGVNM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLL---
-HLEPAGRPGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--ANLGQNR----GSSSKNT------------------TTPSAKW
EG----QQP-------VAASTCQCV------GSFHSASDDTAQQPTALEKADS--P----
---------------------------------PPTPPLS-SSTP---VLP--PPPPPLP
GQGAMSPPPPPPP-----PPLPPPLPGSGTISP-------------P----LPPPP----
PPLPGSKAMSPPAP-PP-P-----------------------PP---LSDSWRTLPPP--
PPPLPGTGGIPPP--PPPLPGFS--------------VPS---------TMGGVEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSSPC--TEAVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APTRKEPKEVTFLDSKKSLNLNIFLKQFKSSNEEVTSMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERTKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRP
KAQLALTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLARDLEPPSQAAGINLEIIRSEASGNLKKLL
EIERKVSASIPEVQKQYAERLQA--SIEASRALDKVFEAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAEKRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEAGSR-VTPTDPPKATEPAT
AS---NA-------------IQSTNHPAS---EPSLDTTA-------AGEPQGWDLVDAV
TPSPQP--------------S-----KEEGGPPAL-----ERRSSWYV-DASDFLVPEDN
-----L-----NAQP------SEGIWPVTLG---------------------D------D
QALKPLEFSSNKP---PG-------VESS-PQNAVDPEAL------WGVRQAKADGTREG
PEDT-----AE---RGHSPHLPC--------------TGPGED-----------------
-------EDQDDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVR--GR----VSKGTSK
RRK-KRPSRNQE--ECAPE-SDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKMVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRSRAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRISDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--TNSVQNQ----SSSSQNT------------------TTPTTKV
EG----QQP-------VVASPCQHM------GSIQSSSVDIAPQPVALEQYITTSALPIP
-PLCS----STPVLPPTPPPLPGL-----G-ATSPLPP-----------PPP-PLPPPLP
GSGTISPPPPP--------PLPPPLPGSGATCPPPPP--------------PPPLP----
PPLPGSGTISPPPP-P--PPPP---LPGTGAVS-----PPPPPPLPSLPDSHKTQPPPPP
PPPLPGMC--PVPPPPPLPRAGQIPP---PPPLPGFSVPS---------MMGGVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLGSPC--TAAVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRP
KAQLVLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLL
EAERKVSTSIPEVQKQYAERLQA--SIEASRALDKVFDAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQIAKAERRKQQLAEE-EARRPRDED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEASGR-VAPTEPPKATEPAT
AS---NPT-------------QGTNHPAS----ERLDTTA-------ADEPQGWDLVDAV
TPSPQP--------------S-----KEEDGPPAL-----ERRSSWYV-DASDFLDPEDT
-----P-----DAQP------SEGVWPVTLG---------------------D------G
QALNPLEFSSNKP---PG-------VKNSH-QDATDPEAL------WGVHRTEADSTSEG
PEDE-----AQ---RGQSTHLPH--------------TGH--------------------
----GEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQ--GR----VSKGTSK
RRK-KRPSRNQE--EFAPD-SDDIKA----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCNQQYRFRVVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQSQ---RGSSPQNTATPK---------------------
-AGVEGQQP-------AAAPTCQPV------DHAQSESLLKAS---QP------------
----------------RVLDQRAP---------TPPPPVP-LLPGSSAEPPPPSPTTPLP
SQA--------------------------------PPP---------------PHP----
-HSCQAWGPWPP-------------------------STPSPPPLPGACGI-----LPPP
PPPLPGMECPPPPP-PLL-PGMG-WGP-PPPP-PPPLP-GTCSPSV----AGDVEEI---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSAH--AEAVEPDF-------SSIERLFSFPAARPKEPATAA
P-ARKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFAEERAKLANADQFYVLLLAVPCFQLRIECMLLCEGAAAMLDMVQP
KAQLVLAACKSLLTSRRLP----VF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLELPRDLEQPSQA------IIRSEASSNLKKLL
ETERKVSASVAEVQEQYTQRLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKRQLAEE-EARRPLGED
---GKP------------------------------------------------------
---VRKGPRKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGASK-AASVDPPRATEP--
--VATGDPSGD--------PVDGTRCPTS---EPSLDAAV-------ANKSRAWDLVDAG
THCPQPTLEQS----------GEG------GPRPL-----ERRSSWYV-DASEDLTTEDT
-----Q-----CPQP------SEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------L----AAGSSSQDAKDPTTL------PGVLQAEAGSTSQG
-----RADTV----HGRSVRPPT--------------AG--------------------P
GG--DRDEDEEDTAPESALDTSLDRSFSEDAVTDSSGSSTLPRSR--GRAS----KGTGK
RRKKR-PSRSQE--EVAPD-SDANKT----------------ERLCVIN-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLLCEGTAVVLD

PF02181 // ENSGT00760000118986_1_Domain_3 (1077, 1281)

MVRP
KAQLLLAACESLLTSRRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAVHSESTTNLKKLL
EMERKLSSSVPEVQEQYAHRLQA--SITDSQALEEVFQAIEQKQLELASYL--CE-DAQQ
LSLEGTLS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGAG
---GKA------------------------------------------------------
---ARRGGGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEAASR-APTTDPPRNKAPGP
GV---GPSTPAT----TRDAVGGASPPSS---EPGLDAAA-------AREPQSWDLADAT
PTSLQP----------------TGDSSEMGGPGSL-----ERRSSWYT-DASDFLPMENP
-----Q-----GPQP------PAGAWPVVLG---------------------D------A
QVLKPLDFSDQPP---KA-------MDL--RPDAEEPPAA------LGAHQAEASSTDEG
PEDA-----AA---HCRHTGLPA--------------AGP--------------------
----DEDGDGELTAPDSSLDTSLDRSFSEDAVTDSSGSSTLPRAQ--GR----TSKGTGK
RRK-KRPSRNQE--EVAPD-PDDNKT----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESAEPELCIRLLQVPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQEGIRYILSNQAYVRQLSLGELWTRPTWMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 263)

EGHALTLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLS------
VVNAIILGPEDVRARAQLRSEFIGNLDLCAG---LPLLGSRGRVAGL-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSLKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 338)

EGHALTLDALDHYKTVCSQQYRFSVVMNELSGSDNVPYVVTLLS------
VINAIILGPEDLRTRAQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHK---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------PPP-PPPLP-GTCSPSA----AG-DEEV---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPH--AEAVEPDF-------SSIERLFSFPAAKPKEPATAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIQAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRALTEERAKLANADQFYVLLLAIPCYQLRIECMLLCEGAAAMLDMVQP
KAQLVLAACKSLLTSRRLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLELPRDLEQPSQAAGINLEIIHSEASSNLKKLL
ETERKVSASVAEVQEQYTQRLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DVQQ
LSLEDTFS----TMKAFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKRQLAEE-EARRPLGED
---GKP------------------------------------------------------
---VRKGPRKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGGSK-AASVDPLRATEP--
--VATGDPAGD--------PVDGTRYPTS---EPSLDAAV-------ANKPRAWDLVDAG
THCPQPTLEQS----------GEG------GPRPL-----ERRSSWYV-DASEDLTTEDT
-----H-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSDQP-------P----AAGSSSQDAEDPTAL------LGVLQAEAGSTSQG
-----REDT---------VRPPT--------------AG--------------------L
GG--DRDEDEEDTAPESALDTSLDRSFSEDAVTDSSGPSTLPRSR--GRAS----KGTGK
RRKKR-PSRSQE--EVAPD-SDANKT----------------ERLCVIN-----------
-----------

------------------------------------------------------------
----------------MPSVVNYSG

PF06371 // ENSGT00760000118986_1_Domain_0 (86, 186)

LKKRLESSDDTWMVQFLELSGLDLLLEALDRLSGR
GVSRISDALLQLTCINCVRALMNSHKGIEYIVSNEGYVRKLSQAL--DTSNVMVKKQVFD
LLAAL

ENSGT00760000118986_1_Linker_0_1 (186, 191)

SIYSL

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 400)

EGHALALDALDHYKTVKNQQYRFSVIMNELSATDNVPYMITLLS------
VINAVILGTEELKTRTQLRNEFIELVGVVLLLPGLRDIEDEDLLIQCET--FEESKSEDD
EELLKICDGIDM--------------NSHHEVFSCLFNKVSSSPVAIQLLSILQTLL---
-HLEPSHHSSI---------------LLWESL-EILAHR

ENSGT00760000118986_1_Linker_1_2 (400, 598)

AILLANDTRGHD---------
--------------FFSRSHLSSPWSNY-LIVTVQGNSIEEVMERMLSIKKCTAQQNSER
K---RSAEGVSESTQTDTDLGESL---SATLSSVT-TAC----------PLAAAAPLLGL
PAATKNKSP-------SQLSACSTS-----------PGQCIS-PSSAGPPLTPSPPP

PF06346 // ENSGT00760000118986_1_Domain_2 (598, 832)

PSP
PPLPTG---------------------------------------MAALPAPPPPPPPLP
GLGNIPPP-PPLPGLGN-IPPPPPLPGLGNIP----------------------PP----
PPLPGLGNIPPPPPLPG-----------LGN-------IPPPPPLPGLGNI-------PP
PPPLPGLGGMPPP--PPPLPGLGGVPPPPP---------P---------PG

ENSGT00760000118986_1_Linker_2_3 (832, 868)

GNVEEI---
----------VVAHVDYALGYAR-PFQ

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1158)

KKVKTPT----------LRMKKLNWQK----LP
SNVVRVAPIVQSSELASDSVHCCTFIAMY----------YGLEMLVKVAPSKPKEKA--A
APVKVEPKEITFLDSKKSLNLNIFLKQFKCSNEEVADMIEKGDRTKFDVEVL----KQLL
KLLPERHEIENLKTFKEEKAKLASADQFYLFLLKIPSYQLRIECMLSCEETTVMLDMLQP
KAETIRRACEDLLTTHRLP----VF-CQLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEV-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKMVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRCEFIGNCSPACLTSPPRDLEDADLLIQLEA--FEEAKAEDE
EELLHVCDGINM--------------NNHQEVFASLFHKVSSSPASAQLLSVLQGLL---
-HLEPSGRSGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLAGKVRPRPSLL--
-------DQAHKSVQ--ADLGQNQ---SDTLAQNT------------------TASGTGI
DA----QQP-------AVASVCQQV------ASTQSSSS-TAVQPTVPPQRAPSPPPPAP
SL-------PDPTTRSPLHHLPG-------------------------------------
------------------------------------------------------------
-------------------------------------------------SSFSSVPPP--
APPLPGFGSALPPP-PPPPPGVGWGP---PPPLPGTSGLP---------MAAGVEEI---
----------IVAQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATMSSPG--TEQVEPDF-------SSIERLFSFPTAKPKEPM-A-
APTRKEPKEVTFLDAKKSLNLNIFLKQFKCSNEEITAMIRAGDTAKFDVEIL----KQLL
KLLPEKHEIENLRTFTEERTKLANADQFYVLLLDIPCYQLRIECMQLCEGTAIVLDMVRP
KAQLVLNACESLLNSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPKDLDQPSQAAGINVEIIRTEAGTNLKKLL
DAEQKVSASIPEVQEQYKHRLQT--SITASRELDAVFSAIEQRKLELADYL--CE-DPQQ
LSLEDTFS----TMRTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCSL--KENKDRKEQMAKAERRKRQLAEE-EARRPLGKD
---GKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGEAEGSSK-VASKDPLRVPEPGE
PL----PAA-------SG-PTGGTSDPAP---ELDLHAAV-------ASEPPGCDFVDTV
IPSPAS--------------H-----GKESGPPPL-----ERRSSWYV-DASDFLDTKDA
-----L-----NTCP------STEAWPVVLG---------------------D------S
HALKLLEFSSKEP---PG-------SQSSGPQDTEDPENS------QGVHLAKADSTSQG
PED---------------------------------------------------------
-IGPGGDEDREDTALESALDTSLDKSFSEDAVTDSSGSGTLPR----GL----ASKGSSK
RRK-RRPARSQE--EVAPD-SDDNKT----------------KRLCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDSDPTE
ANLESAEPELCIRLLQVPSVVN------------------------LDL

PF06371 // ENSGT00760000118986_1_Domain_0 (110, 187)

LLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQEGIRYILSNQAYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 196)

IYSPKG-AL

PF06367 // ENSGT00760000118986_1_Domain_1 (196, 342)

TLDALDHYKTVCGQQYRFSVIMSELSDSDNVPYVATLLS------
VVNAIILGPEDVRARAQLRSEFIGLQLLDIL-TRLRDLEDGDLLIQLET--FREAKAEDE
EELLRAFGGIDV--------------NSHQEVFSALFHKVHAAGSASQDSVGAQGSE--G
AEGLPRSHP-----------------AL--------------------------------
-------------LDLRQLES----HTPSPQGPGQECTLEEMVERLLSIKGRPRPRSL--
-------DKAHKSTQ--ADLGQSQ---RGSSPQNS------------------GAPTADL
GG----QQP-------AAALGSPLV------ASIQGERG-PAPQPTAPEQLVAPRRPLCS
HTPPGG--CGSLLLGPCTARAQGL-----G-VLMPREG---------------------Q
GQGWLEARSPASLD------------------------------TGPWAPALPAVC----
LPWAGPQAGH-PCQ-PS----------------------RPAPPAPGLGGQAPTPR--WW
SPTSPAS-SGSSPSPRPNPRSRRWPRPGRSPRRPPWEVHI---------PSRGLQTV---
----------IIAAKDSWLALGWAPGRTPLPALQ--A-------CTTCPWTWGAGVSLTG
GPSPTEHSSM----WATLSSPD--AEVVEPDF-------SSIERLFSFPTAKPKEQAVA-
-PARKEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDSTKFDVEVL----KQLL
KLLPEKHEIENLRSFTEDQARLASADQFYLLLLSIPCYQLRIECMLLCEGTAVVLDMVRP
KAQLLLAACETPLLPDPRP----HPSTRPRDSLSALPS

PF02181 // ENSGT00760000118986_1_Domain_3 (1119, 1281)

QGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEESHPDLLQLPQDLELPARAAGINLDAVHSESSTNLKKLL
EMERKVSSSVPEVQEQYAHRLQA--SITDSQALEQVFQAIEQKQLELASYL--CEPNAQQ
LTLEDMLS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGVG
---GKA------------------------------------------------------
---ARRGGGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEVASR-APTTDPPRNKAPAA
TR---DA-------------VGGASPPSS---EPGLDAAA-------AREPQSWDLADAT
PTSLQP----------------TGDSSETGGPGSL-----ERRSSWYT-DASDFLPMENP
-----Q-----GPQP------PAGAWPVVLG---------------------D------A
QVLKPLDFSDQPP---KA-------MDL--RPDAEEPPAT------LGARQAKASSTDEG
PEDA-----AA---HCRHAGLPA--------------AGP--------------------
----DEDEDGELTAPDSSLDTSLDRSFSEDAVTDSSGSSTLPRAQ--GR----TSKGTGK
RRK-KRPSRNQE-AEVAPD-PDDNKT----------------KRLCVIQ-----------
-----------

--------------------------------MSIKKEGAHKKWAALKEKLGPQDTDQSE
ANLENAEPELCIRLLQMPSVVNYSGLKKRLESSDDAWMVQFLELCGLDLLLEALDRLSGR
GVARIS

PF06371 // ENSGT00760000118986_1_Domain_0 (127, 188)

DALLQLTCINCVRAVMNSHRGIEYIVSNEGYVRKLFQAL--DTTNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

YSS

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

DGHGLALDALDHYKNVKNQQYRFSVIMNELSNTDNVPYMVTLLS------
AINAIILGKEDLRTRTQIRNEFIGLQLLDIL-DKLRDIEEEDLLIQCDT--FEEFKIEDD
EELLKICDGINM--------------NDHHEVFSSLFNKVSRSPVSIQLLSILQSLL---
-HLEPSHQSSL---------------LLWESL-DAVVNRALLLANDIQG-----------
------------------------------------NTVEEVIERLLSIKKHPNKQKQ--
-------AEKHLSGNA-NGGIQTQ--L---------EPCTSA--VQS--LLGSPNPC-TT
PEASSGPQACEKKTSSSPLSACF-------------TSPQTSNPPPNAVPAP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------LPP-PPPPLPGMAGDHI-------------EAV---
----------VASQISCPLGS-IRPPY

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1282)

KAVKTPT----------LRMKKLNWQK----LP
SNVVRESHSM----WASVSSSS--EETIEPNY-------TSIEQLFCFPQPTPKEKTA--
APVKAEPKEITFLDSKKSLNLNIFLKQFKCSNEEVVAMVQNGDRTKFDVEVL----KQLL
KLLPEKHEIENLKAFKEEKSKLANADQFYLLLLQIPSYQLRIECMLICEETTVVLDMIQP
KAEAIRKACEDLLTSHRLP----LF-CKLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEEVENSHTDLLELPEDLEYVSKAAGINLDIIRSESSANLKKLL
ELQRKVSSANDDVKQQYEKPIQD--SIDASRKLEEDFETIDRKREELANYL--CE-DPSK
LSLEDVFS----TMKTFRDLF

ENSGT00760000118986_1_Linker_3_4 (1282, 1398)

IRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRLKGEN
---GKV------------------------------------------------------
---VKKGLVKQEDVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFTLRKTKN-RHESDALPK-ASPAEIPEESRSGK
ST--KDLQAGGQQVDD--KAKQNNGHPSE----STLSLAA-------VLPEMGRDVGDVS
APNQALPENNA----------EGNLPPGSRTEGPLVNLVETKGDGQ----------GDGM
-----A-----SLQP------GLSSGAISFS---------------------A------A
NIGANITFVSSSSGAALREQL---NGSTSEEQDNKCS---LESCRPAQDIQLSQNGGNPS
T---------------P-STPCD--------------GA-------------------HQ
AELKEMAKENEDPGTDSLLDTSQEKSFSEEPATDSSCSATLPPGE--THTDREKQRTSGK
RRKKKRHSKSYS-AEIETD-SGDYKT----------------KKGCVVQ-----------
-----------

--------------------------------MSIKKEGAHKKWAALKEKLGPQ

PF06371 // ENSGT00760000118986_1_Domain_0 (55, 187)

DTDQSE
ANLENAEPELCIRLLQMPSVVNYSGLKKRLENSDDAWMVQFLELCGLDLLLEALDRLSGR
GVARISDALLQLTCINCVRAVMNSHRGIEYIVSNEGYVRKLFQAL--DTTNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 192)

IYSSD

PF06367 // ENSGT00760000118986_1_Domain_1 (192, 407)

GHGLALDALDHYKNVKNQQYRFSVIMNELSNTDNVPYMVTLLS------
AINAIILGKEDLRTRTQIRNEFIGLQLLDIL-DKLRDIEEEDLLIQCDT--FEEFKIEDD
EELLKICDGINM--------------NDHHEVFSSLFNKVSRSPISIQLLSILQSLL---
-YLEPSHHSSL---------------LLWESL-DAVVNRALLLAND

ENSGT00760000118986_1_Linker_1_2 (407, 720)

IQG-----------
------------------------------------NTVEEVIERLLSIKKHPNKQKR--
-------AEKRLSGNA-NGGIQTE--R---------EPCTSA--VQS--LMGSPNPC-KT
PEAPSGPQACEEKTSSSQLSACF-------------TSPQTSNPPPNAAPALPPPP--PP
PP------------PPPPPPLPSG---P-AAMPPTA-SV--NLPPAPPLPGIPPPPPPLP
GMAV--------------IPPPPPLPGM-AVIPPPPPPLP---GMGG-----IPPP---

PF06346 // ENSGT00760000118986_1_Domain_2 (720, 866)

-
PPLPGMGGIPPP-----------PPLPGLGG------IPP-PPPLPGLAGI-----PPPP
--PLPGMGGIPPPP-PL--SGMGGIPP-PPPPLPGMAGDNI-------------EAV---
----------VAPQFSCPLGF-ISP

ENSGT00760000118986_1_Linker_2_3 (866, 868)

PR

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1281)

KAVKTPT----------MRMKKLNWQK----LP
SNVVRESHSM----WASVSSSS--EETIEPNY-------TSIEQLFCFPQPTPKEKTV--
APVKAEPKEITFLDSKKSLNLNIFLKQFKCSNEEVAAMVQNGDRTKFDVEVL----KQLL
KLLPEKHEIENLKAFKEEKSKLANADQFYLLLLQIPSYQLRIECMLICEETTVVLDMIQP
KAEAIRKACEDLLTSHRLP----LF-CKLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEEVENSHTDLLELPEDLEYVSKAAGINLDIIRSESSANLKKLL
ELQRKVSSANDDVKQQYEKPIQD--SIDASRKLEEDFETIDRKREELANYL--CE-DPTK
LSLEDVFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRQKGEN
---GKV------------------------------------------------------
---IKKGLVKQEDVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1415)

DALLADIRKGFTLRKTKN-RHESDAPPK-TLPAEIPEENRSGK
SI--KDPQAGGQQMDD--KAKQNNGHPSD---ESTLSLAD-------ALPEMGRDVGDAS
APNQALPENNA----------GGNLPRGSRTEGPLVNLVEADGAGQ----------GAGM
-----A-----SLQP------GLGSGAISFS---------------------A------A
NIGANITFVSSSSGAALREQL---NGSTSEEQDKKCPGDGLESCRLAQDIQLNQNGGNPS
T---------------P-STPCD--------------GA-------------------HQ
ADLKEMAKENEDPATDSLLDTSQEKSFSEEPATDSSCSATLPPGE--THTDREKQRTSGK
RRKKKRHSKSYS--EVETD-SGDYKT----------------KKGCVVQ-----------
-----------

--------------------------------MSVKKEGAHKK

PF06371 // ENSGT00760000118986_1_Domain_0 (44, 187)

WAALKQKLGPQETDQSE
ANLENAEPELCIRLLQMPSVVNYSGLRKRLENSDDAWMVQFLELSGLDLLLEALDRLSGR
GVARISDALLQLTCISCVRAVMNSHKGIEYIVSNEGYVRKLFQAL--DTTNVMVKKQIFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSS

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 464)

DGHSLALDALDHYKATCPKQYRFSIIMNELSNTDNVPYMVTLLS------
AINAIILGKEELRTRTQIRNEFIGLQLLDVL-DKLRDIEEEDLLIQCDT--FEEFKIEDD
EELLRICDGINM--------------NDHHEVFSSLFNKVSRSPVSVQLLSILQSLL---
-HLEPSHHSSL---------------LLWESL-DAVVNRALLLANDIQG-----------
------------------------------------NTVEEVIERLLSIKKHPNKQKR--
-------AENRLSGSA-AGAVQ--AEP---------EPCARA--ARC--PVGSSNPT-RA
PATSSGPLDNEKKISSCQFTACC-------------ALPEKSNPP--SNTAPNPAP----
---------------PAPPPLPSG---T-AAMTPSSPMT--NAPPAPPLPGIPPPPPPLP
GMGI--------------PS------PP-PPPPPPPPPLP---GMGG-----IPPP----
PP-------P---------------LPGMGG------MPPPPPPLPGMGGI-----PPP-
------------PP-PL--PGMGGIPP-PPPLLPGMAGDYI-------------EAV---
----------VASQFSCPLGL-GRPPH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1281)

KTVKTPT----------LRMKKLNWQK----LP
SNVVRESHSM----WASVSSSS--EEMIEPNY-------SSIEQLFCFPQPTPKEKAA--
APVKAEPKEITFLDSKKSLNLNIFLKQFKCSNEEVTAMIQNGDRTKFDVEVL----KQLL
KLLPEKHEIENLKAFKEEKAKLANADQFYLLLLQIPSYQLRIECMLICEETTVVLDMIQP
KAEAIRRACEDLLTSHRLP----IF-CQLILKVGNFLNYGSHTGDADGFKISTLLKLTET
KA---NQTRITLLHHILEEVENSHKDLLELPKDLEYVSKAAGINLDIIRTESGANLKKLL
ELQRKVLSSNEDVKQQYEKPIQD--SIDASRKLEEEFETIEKKREELANYL--CE-DPSK
LSLEDIFS----IMKTFRDLFIRAL--KENKDRKEQAAKAEKRKKQLEEE-EGKRQKGEN
---GKV------------------------------------------------------
---IKKGLLKQEEVCVIDALLADIRKGFTLRKT---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPPDSDP

PF06371 // ENSGT00760000118986_1_Domain_0 (59, 187)

TE
ANLENADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSQQGIGYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSVVMNELSGSDNIPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CSLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQSQ---RGSSPQHTATPK---------------------
-AGVEGQQP-------A-APTCQPV------DHAQSESLLKAS---QP------------
----------------RALEQRA---------PTPPPPVP-LLPGSNAEPPPPPPPPPLP
GVGT--------------EA--------L--LAPPPPP---------------PP-----
-PLLGLGAMAPP-------------------------APPPPPPLPGACGI-----LPPP
PPPLPGMECPPPPP-PLL-PGMG-WGP-PPPP-PPPLP-GTCSPSV----AGDVEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSSH--AEAVEPDF-------SSIERLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADRFYVLLLAIPCYQLRIECMLLCEGAAAMLDMVQP
KAQLVLAACKSLLTSRRLP----VF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLELPRDLEQPSKAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYAQRLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFREL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAATAERRKRQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPMKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEGGSK-VASVDPPRATEPAI
--VATGDPAGD--------PVDGMRCPTS---EPSLDAAA-------ASKSRAWDLVDAG
THCPQPTLEQS----------GEG------GPRPL-----ERRSSWYV-DASEDLTTEDT
-----Q-----CPQP------SEGAWPVTLG---------------------D------A
QALKPLKFSSTQR-------P----AAGSSSQDAKDPTAL------LGVLQAEASSTSRG
-----REDTV----HSRSVRPPT--------------AG--------------------P
GG--NRDEDEEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRSR--GRAS----KGTSK
RRKKR-PSRSQE--EVAPD-SDANKT----------------ERLCVIN-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---KP------------
----------------RTLEQQAS-----P----LPPSTP-LLPGSSAEXXXPP------
------------------------------------------------------------
----------------------------------------LSPPLTSSCEF-----PPPP
PPPLPGMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIQAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGGK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPAS---KPNLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 459)

EGHALTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VVNAVILGPEDLRTRTQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRVCNGLNM--------------NSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTSRSGQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVAERLLFSRGRPRPTSL--
-------DKAHKSIQA--NLGQSP---RDRSPQNTAAPL---------------------
-AGMEGQQQ-------ATAPAHQHP------VGLQSTSGKTAP--QQPAHSPPPPAPPLP
SSSPGP-----LSPPPSLPSLEAG-----SPLIPPPPPLP-GLGSMFSPPAPPPPPPPLP
DLGT--------------TP--------S--PVPPPPPLP-----VL-----PPPP----
PPLPGLGAVSPP-------------------------APPLPPPLPGSCGI-----LPPP
PPPLP----------PPP-PGGG-WGP-PPPP-TLP--------------AGGVEEL---
----------IVAHVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLSSPG--TDAVEPDF-------SSIERLFSFPVAKPKEPTA--
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTAMIRAGDTAKFDVEVL----KQLL
KLLPEKHEIENLRTFTEERAKLANADQFYVLLMDIPCYQLRLECMLLCEGTAIVLDMVRP
KAQLVLAACESLLTSHRLP----VF-CQLILKIGNFLNYGSHTGDADGFKMSTLLKLTET
KS---QQNRVTLLHHVLEEVEKSHPDLLQLPQDLAQPSQAAGINLEVIRSEASTNLKKLL
GTERKVSTSDPEVQEQYAQRLQD--SIAASQALDQVFEAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKIFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQVAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDSEVGSK-ASAEL-LRATVP--
--AAASDPAQG--------PREDASHPAP---ELGLDAAA-------AGRPQGWDLADAV
TPSPGPA---G----------EEG------SPRPL-----ERRSSWYV-DASDFLAPEDT
-----L-----NPQP------SEGAWPVTLG---------------------D------T
RALKPLQFSGDKR-------P----GAESSSQDPEELGGL------QGVHQAKAHGTGQG
-----PEDTAI---QGQSAGLPA--------------TG--------------------P
GG----DEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRSR--GRAS----KGTSK
RRKKR-PSRSQE--GNLGP-GQRR------------------------------------
-----------

---------------------------------MSVREGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVMNSPRGIEYILSNPAYARQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSVIMSELSDSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRSEFVGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELLHVCGGVNM--------------NSHQEVFASLFHKVSCSPASTQLLSMLQGLL---
-HLEPTHRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRLRPSPL--
-------DKAHKSVQ--ADLGQGQ---RGSSPENG------------------TAPEASV
EG----QQP-------AVAQAWQLV------GSNQRESGGEAPQPRALEQRTPAPPPP--
-----------------------------------APPLP-SSTT---GAPP-PSLPPLP
GLGATSPP--------------------------------------A----APPPP----
PPLPGLRAMAPPAP-PP-PPPP---LPGSCGLL-----PPLPPPLPGMGC------PP--
PPPLPGAGWGPPP--PPPLPGLP--------------GPP---------AVDSVEEV---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SKVAREGNSM----WAALGSPD--AEAVEPDF-------SSIERLFSFPVAKPREPA-AA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVTGMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFGEDRARLANADQFYLLLLGIPCYQLRVECMLLCEGTAVVLDMVRP
KAQLVLAACESLLTSHQLP----VF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEVERSHPDLLQLPQDLDQPSRAAGINLEVIRSEASSNLKKLL
ETEHKVSASVPEVQEQYSGRLQA--SIEASRALDKLFEDIEQKRRELADYL--CE-DAQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FIRAL--KENKERKDQAARAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---GRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRADADKGSR-AAVGDPPGAME-SA
AS---RDPA-------GDPRGGTRR-PTS---GPGLDAAA-------TKEPPGWDLVDAV
TP--GP--------------QPAQEPAEEGGPGRL-----ERRSSWYV-DASDFLTPEDA
-----Q-----CPQP------SQGAWPVTLG---------------------D------A
RALQPLKFSSEKP---PG-------APSSS-QDAEGPASS------GDIRRAEADSTSQ-
-EDA-----AV---LGRSAGLPA--------------AGL--------------------
-GGDA---DEEDPAPESALDTSLDRSFSEDAVTDSSGSGTLPRAR--RA-----SKGPGR
RRK-KRAARSQ--EEVAPE-CDDSST----------------KRLCAIQ-----------
-----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MLLCEGAAAVLD

PF02181 // ENSGT00760000118986_1_Domain_3 (1077, 1281)

MVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGAAS----VDRPRTLRP--
--VATSNSAGD--------PVGGTHCPTS---KPDFDATM-------ASEPRGWDLVDAV
TPALSPPWSSR----------RRV------VPAPG-------------------------
---------------------ERRAWPVTLG---------------------D------A
QALKPLKFSGNKP-------L----QLEV-------------------------------
-----------------QRGTPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--G-SPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQDS

PF06371 // ENSGT00760000118986_1_Domain_0 (57, 187)

DPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRARTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPTLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLDQSQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHAQSESILKVS---QP------------
----------------RALEQQAS-----T----PPPPPP-LLPGPVAKAPSPPRPPPAQ
AP----------------------------------------------------------
-----------------------------------------------VRVL-----APPT
LRPTPGLGIARPTP-PLP-PGMG-WGP-PPPP-PPLLP-CTCSAPV----AGGMEEV---
----------IVAQVDHGLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AEAVELDF-------SSIERLFSFPAAKPKEPTTVA
ARARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLL
ETEWKVSASVAEVQEQYTERLQA--SISAFRALDKLFEAIEQKQRELADYL--CE-DAQQ
LSLEDTFS----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-AASMDPPRATEP--
--VATSNPAGD--------PVGSTRCPAS---EPGLDATT-------ASESRGWDLVDAA
TPGPQPTLEQS----------EEG------GPRPL-----ERRSSWYV-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNQP-------P----AAGSSRQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSHGARPPA--------------AG--------------------P
GG--DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKE

PF06371 // ENSGT00760000118986_1_Domain_0 (50, 187)

KLGAQDSDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCISCVRAVLNSQRGIEYILSNQAYVRQLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 276)

EGHMLTLDALDHYKTVCSQQYRFSVIMNELSDSDNVPYVVTLLS------
VINAIILGPEDLRTRTQLRGEFTGLQLLDVL-TRLR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---QP------------
----------------RTLEQQAS-----P----LPPSTP-LLPGSSAEPPPPPPPP---
-----------------------------------PPP---------------PLP----
-D---LGATVPP-------------------------APPLSPPLTSSCEF-----PPPP
PPPLPVMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLA-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGSK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHRPAS---KPDLDATM-------ASESRGWDLVDAV
TPCPQPMLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---KP------------
----------------RTLEQQAS-----P----LPPSTP-LPSPSPPTPTFPP------
------------------------------------------------------------
----------------------------------------C--HPPCSCEF-----PPPP
PPPLPGMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNLKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGGK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPGS---KPNLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDA
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWVALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGSWMVQFLEQSGLDLLLEALARLSGR
GVSRIADALLQLTCVSCVRAVLNSQPGIGYILSNQGYVRRLSLAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 408)

EGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNAPYVVTLLS------
AVNAIILGPADLRTRTQLRSEFIGLQLLDVL-NRLRDLEDADLLIQLEA--FEEARVEDE
EELLHVCDGINM--------------NSHQEVFTSLFHKVSCSPASAQLLSVLQGLL---
-HLEPSGSSGQ---------------LLWEAL-ESLVNRAVLLASDERKAQPTGKTLSSG
CAGRLPRACHPSLAHLPTLPRPLPDLKVPSRVTAQECTLEEVVERLLAAKGRPRPSPQ--
-------DRAHKSVQ--ADLDRSQ---RDRPPKTI------------------APGA---
VD---TPQP-------AVAPACQQV------ASTQSSNV-TATQPVAPQQRAPRPPPPAP
PVL-G------PTPEPSLHPMPGL-----G-AA---------------------------
-----SAP----------------------------------------------------
--------------------------------------VPPPPPLPSLGSPFFSAPPP--
APPLPGCGSALPPP-PPPLPGTGCPP--PPPPLPPG--VG----------WAGMEEV---
----------IVAQVDHGLGSTWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAQEQNSM----WATLSGPG--TQQVELDF-------SSIERLFSFPTAKPKECT-T-
APTRKEPKEVGTGWD--------GLHGPHCSNEEVTAMIRAGDTAMFDVEVL----KQLL
KLLPEKHEIENLRTFTEDRAKLASADQFYVLLLDVPCYQLRIECMLLCEGTAVMLDMVRP
KAQLVLNACERLLTSHRLP----IF-CQLILKIGNFLNYGSHTGNADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLAGDLEQPSQAAGINVEIIRTEASANLKKLL
DTERKVSASVPEVQEQYKQRLQA--SITTCQELNSVFEAIEQKKLELADYL--CE-DPQK
LSLEDTFS----TMRTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTCAL--KENKDRKEQVEKAVRRKQQLAEE-EARRPQGGD
---RKP------------------------------------------------------
---GRKAPGRQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDAEGPPPTAAA-----------
-----SDTA-------QGP-AGGTGCPAP---DLDLRVTV-------TSEPQGWDLGDAV
SRSPVP--------------P-----GEESGLPRL-----ERRSSWYV-DARDFLDAEDA
-----L-----NVCP------SKEACPVALG---------------------D------S
QALKPLQFSIEKP---LG-------SQSSGPQDHENPKAS------QGVHQAKADSTSLA
PED---------------------------------------------------------
-IGPSGDEDREDTAPESALDTSLDKS-SEHAVTDSSGSGTLPRAQAWGR----ASKGSSR
RRK-KHPSRSQE--ELAPG-SDDNKT----------------KRLCVVQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESAEPELCIRLLQMPSVVNYSGLRKRLESSDGGWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCISCVRAVMNSQQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 465)

EGHALTLDALDHYKMVCSQQYRFSVIMSELSDSDNVPYVVTLLS------
VINAIILGPEDLRSRAQLRSEFIGLQLLDIL-TRLRDLEDADLLIQLEA--FEEAKAEDE
EELQRISDGINM--------------NSHQEVFASLFHKVSCSPASAQLLSVLQGLM---
-HLEPAGRSGQ---------------LLWEAL-ENLVNRAVLLASDAQA-----------
------------------------------------CTLEEVVERLLSIKGRPRPSPL--
-------DKAHKSVQ--TNSVQNQ----GSSSQNT------------------TTPTTKV
EG----QQP-------VVASPCQHV------GSIQSSSVDIAPQPVALEQCITALPLPTP
-PLSS----STPVLPPTPPPLPGP-----G-ATSPLPP-----------PPP-PLPPPLP
GSGTTSPPPPP------------------------PP--------------PPPLP----
PPLPGSGTISPPPP-P--PPPP---LPGTGAVS-----PPPPPPLPSLPDSHKTQPPP--
PPPLPGMC--PVPPPPPLPRAGQIPP---PPPLPGFSVPS---------MMGGVEEI---
----------IVAQVDHSLGSAWVPSHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVARERNSM----WATLGSPC--TAAVEPDF-------SSIEQLFSFPTAKPKEPS-A-
APARKEPKEVTFLDSKKSLNLNIFLKQFKCSNEEVTSMIQAGDTSKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLSNADQFYVLLLDIPCYPLRVECMMLCEGTAIVLDMVRP
KAQLVLTACESLLTSQRLP----VF-CQLILKIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQSRVTLLHHVLEEVEKSHPDLLQLSRDLEPPSQAAGINVEIIHSEASANLKKLL
EAERKVSASIPEVQKQYAERLQA--SIEASQELDKVFDAIEQKKLELADYL--CE-DPQQ
LSLEDTFS----TMKTFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FTRAL--KENKDRKEQMAKAERRKQQLAEE-EARRPRDED
---GKP------------------------------------------------------
---IRKGPGKQEEVCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTEASGR-VAPADPPKATEPAT
AS---NPT-------------QGTNHPAS----EPLDTTA-------ADEPQGWDLVDAV
TPSPQP--------------S-----KEEDGPPAL-----ERRSSWYV-DAIDFLDPEDT
-----P-----DAQP------SEGVWPVTLG---------------------D------G
QALNPLEFSSNKP---PG-------VKSSH-QDATDPEAL------WGVHRTEADSTSEG
PEDE-----AQ---RGQSTHLPR--------------TGP--------------------
----GEDEDGEDTAPESALDTSLDRSFSEDAVTDSSGSGTLPRVQ--GR----VSKGTSK
RRK-KRPSRNQE--EFVPD-SDDIKA----------------KRLCVIQ-----------
-----------

---------------------------------MSVKEGAQRKWAALKEKLGPQD

PF06371 // ENSGT00760000118986_1_Domain_0 (56, 187)

SDPTE
ANLESADPELCIRLLQMPSVVNYSGLRKRLEGSDGSWMVQFLEQSGLDLLLEALARLSGR
GVARISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALC

ENSGT00760000118986_1_Linker_0_1 (187, 191)

IYSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 466)

EGHALTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLS------
VINAVILGPEDLRTRTQLRNEFIGLQLLDVL-ARLRDLEDADLLIQLEA--FEEAKAEDE
EELLRVSGGVDM--------------SSHQEVFASLFHKVSCSPVSAQLLSVLQGLL---
-HLEPSLRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVVERLLSVKGRPRPSPL--
-------VKAHKSVQA--NLGQNQ---RGSSPQNTTTPK---------------------
-PSVEGQQP-------AAAAACEPV------DHTQSDSVLKVS---KP------------
----------------RTLEQQLA-----L----PSLPG-----------PPPPLPD---
-----------------------------------LG-----------------------
-----------A-------------------------TPPLSPPLTSSCEF-----PPPP
PPPLPGMGCPPPPP-PLL-PGMG-WGP-PPPP-PPLLP-CTCRPPV----AGGVEEV---
----------IVSQVDHSLGSAWVPRHR

PF02181 // ENSGT00760000118986_1_Domain_3 (869, 1281)

RVNPPT----------LRMKKLNWQK----LP
SNVAREHNSM----WASLSSPD--AETVEPDF-------SSIEQLFSFPAAKPKEPTTAA
APARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVL----KQLL
KLLPEKHEIENLRAFTEERAKLANADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRP
KAQLVLAACESLLTSRQLP----IF-CQLILRIGNFLNYGSHTGDADGFKISTLLKLTET
KS---QQNRVTLLHHVLEEAEKSHPDLLQLPQDLEQPSQAAGINLEIIRSEASSNMKKLL
ETERKVSASVAEVQEQYTERLQA--SISAFRALDELFEAIEQKQRELADYL--CE-DARQ
LSLEDTFG----TMKAFRDL

ENSGT00760000118986_1_Linker_3_4 (1281, 1398)

FLRAL--KENKDRKEQAAKAERRKQQLAEE-EARRPRGED
---GKP------------------------------------------------------
---VRKGPGKQEELCVI

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFQLRKTARGRGDTDGGGK-VASMDPPRATEP--
--VATSNSAGD--------PVGGTHCPAS---KPNLDATM-------ASESRGWDLVDAV
TPCPQPTLEQS----------EEG------GPPPL-----ERRSSWYE-DASDVLTTEDP
-----Q-----CPQP------LEGAWPVTLG---------------------D------A
QALKPLKFSSNKP-------P----AAGSSSQDAKDPTSL------LGVLQAEADSTSEG
-----LEDAV----HSRGARPPA--------------AG--------------------P
GE--DGDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRAR--GRAS----KGTGK
RRKKR-PSRSQE--EVPPD-SDDNKT----------------KKLCVIQ-----------
-----------

---------------------------------MSVKEGAQRRWTALKEKLGPQDSDPTE
ANLENADPELCIRLLQMPSVVNYSGLRKRLESSDG

PF06371 // ENSGT00760000118986_1_Domain_0 (96, 188)

SWMVQFLEQSGLDLLLEALARLSGR
GVARIADALLQLTCVSCVRAVLNSRQGLEYILSNQGYVRQLSQAL--DTSNVMVKKQVFE
LLAALCI

ENSGT00760000118986_1_Linker_0_1 (188, 191)

CSP

PF06367 // ENSGT00760000118986_1_Domain_1 (191, 468)

EGHTLTLDALDHYKTVCSQQYRFSIIMSELASSDNIPYVVTLLS------
VINALILGPEDLRTRSQLRNEFIGLQLLDVL-TRLRDTEDGDLLIQLEA--FEESKAEDE
EELLRVCGGINL--------------SSHEEVFASLFHKVSHSPVSAQLLSVLQGLL---
-HLDPASRSSQ---------------LLWEAL-ESLVNRAVLLASDAQE-----------
------------------------------------CTLEEVTERLLSAKGRPWPRPV--
-------DQAHKSVQA--DLGLNQ---------NLSDPM---------------------
-MGLEGHPP-------AAAPTCAEH------EGLQHERRTF-P--QQAALEPLSPT----
--------------------------------PPPPPPPPHTLCQARDTCPLTAPSLPLP
GPGA--------------T-------------------SP-----ST-----APSP----
PPLSGPGAMSPS-------------------------APPPPPPLPGPWGH-----PPPP
SLPLPGFTGLPSPT-PLPPQGMG-C----PPP-PPPLP-GTWDPTA----AGGAEEA---
----------IVAQVDHSLGSAWVPRH

PF02181 // ENSGT00760000118986_1_Domain_3 (868, 1283)

RQVNPPT----------LRMKKLNWQK----LP
PSVAQEGHSM----WASLGSLG--PEAVEPDF-------SSIERLFSFPVAPPKET-AAA
APARKEPKEVTFLDSKKSLNLNIFLKQFKXXXXXXXXXXXXXXXXXXXXXXX----XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXLLTSHQLP----VF-CQLILKIGNFLNYGSHTGNADGFKINTLLKLTET
KA---NQSRVTLLHHVLEEVEQSHPDLLQLPRDLEQVSQAAGIHLEAIRSEVSSNLRKLL
ETQQKVLAAIPEVQEQYAERLQV--SIVACQALDTF--EIDQKKLELANYL--CE-A-QQ
LSLEEPLT-----MXXXXXXXX

ENSGT00760000118986_1_Linker_3_4 (1283, 1398)

XXX--XENKERKEQAAKAERRKKQLAEE-EAQRQRGED
---GKP------------------------------------------------------
---VRRGAGRQEEVCII

PF02205 // ENSGT00760000118986_1_Domain_4 (1398, 1413)

DALLADIRKGFRLRKTARGRADLEDSTK-AAA-DPAKDQ----
----KPAAAGL--------PPGGPSCPTS---EL-----A-------PGKSQGLDLEDAV
PPEPHPT--------------QFG------SPAPP-----ERRSSWYM-DASDSLGMEDP
-----Q-----GPQP------SAGPWPVVLG---------------------E------S
QALKPLKFFGEKL-------L----GTTDSCQETTEPTTL------QGTCQAEADGSSAG
-----SGAFAL---S----SLPA--------------AG--------------------P
SG----EGDEEDMAPESALDTSLDRSFSEEAVTDSSGSGSLPRAR--ARST----KGTGR
RRKKR-LARSQE--EFAPD-SDDNKP----------------QRFCALQ-----------
-----------