Query Results 

------------------------------------MHVMNCVSLVGDKKNGTLAPAAGF
MIGQTPPPPPPSPPPPP-P----SCPFLGEGFPPSPDKALPAQGGLSGE--------ALI
---LP-LPAGLPRTSHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

FSHLGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-TKSPLSKRGGTSNASFREAREEITILDAKRNMNIGIFLKQF
KKSPPSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKAFSGDVAKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSALYTDITILRTAIQELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAVLLNFSKKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKDNIQPDGELCQQMEEFLQFALEKLTELQRWKQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCVKFNKAVKXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXX------XXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXXXXXXXXXXX------XX-XXXXXX
XXXXXXXXXXXSSQAHRPL-ASGGEKVARDPPLAWQ-NQILP-SRPE--AAA--FALPRV
RH---SVLRKRNSEPVGLGPKR-SPPLSPLALGIKEHELVTGLAQFDLQAPKGPEETPRL
TVNDLSP----MELAPLRFG-SPQSLGDGNGS-LMPVDRSAQKG-PSPALEV-----G--
GAASVEPSSAAPVSVGSSDPENKDPAPLLYISDT-TDCSLTLDCSEGTDSRPEVGDPG--
EGADGEGSVSSGAGEA---G-GSQVS-SNPACSPPGAAPA----PS-----GKSEPS---
-CRAL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MHVMNCVSLVSDKGNGNTAMAAGF
MTAQAPPPPPP-------PP-PPLGPYSGEGLPPSPPPPPP----LPGG--------PPG
---PP-PPPGLPPNSHLNGYNQL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFYWKTIPEEQVRGKT--NIWTLAASQQHR
YQIDTKTVEELFGQQEDA-TMAPPSRRGGSLHSSSREAREEITLLDAKRSMNIGIFLKQF
KKSPPSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKAFSGDVAKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDMTILRNATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDVVLLNFSEKLLHVQEA
ARLSLDNTEAELHSLFVRTKSLKENIQRDRELCQQMEDFLQFALEKLAELERWKRELQDE
AHTLIDFFCEDKDTVKLDECLQIFRDFCIRFNKAVKDNHERQVQELRQLQRLKELEQKRR
SWTAGEFG-FGRSS----SENDVELLTKRGAED-L-PPFLC-CRP------ASPSYRP-P
TTRRSRLSLDTMADRELLSFLERST--GSPE-EL-KPSNSSRGCL-------WQVPPDGA
CREPGEPRGQDSSLAHRPR-ALEGQEEALHPATAWA-SWLPA-AHPE--DPA--CTLRHP
RRSGVSTLRKRNSAPVGLDPVRSSPPLSPLALGIREHELVTGLAQFNLQAPKGPEEPARL
TGNDCSP----MELVSVGDA-SPQSLGAPNSSPTTPVGRGARVA-PSPVP-------QDG
EAAPYEPRSAAQLSEGSSDPGSQDPEPLFCISDT-SDCSLTLDCSEGANSRPLEGDPG--
QAGDGEGSASPGAWEM---G-GSQAA-SKPICSPTAGAPAAASTPG--SVSGKSEPE---
SCKGG-PPRDRP-ARGREAT-ALRRSSPREAPPLAAPLRAGAARRSAGPLGPVRPAGPVR
PVRTLTSCEDESMRRVVPISRAGRAPPAA--KGSPREAP-G-----GP-APPPPPLARRS
STRGTADASPARPAT----------------------APAARPGREPP-SLLRSSFRKPS
AKPVRNVPR--PKPEEDKACRAGAQGPDGPGEPPRA-APAASVPRGPAPVPSFARNTVAS
SSRSQRLDSPAP-ATAPGLTRTTSQRQLRVKGG-PEGA-APKDSSA---LRRAGSARTLR
KGSESA-EGPGAGAESPPKGR----------LKEAGRAAPGRGLHPSRK

------------------------------------MHVMNCVSLVSDKGNGNTAMAAGF
MTAQAPPPPPP-------PPPPPLCPY-----------SXP----LPGG--------PPV
---PP-PPPGLPPNSHLNGYSQLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFYWKTIPEEQVRGKT--NIWTLAASQQHH
YQIDTKTVEELFGQQEDA-TMAPPSRRGGSLHSSSREAREEITLLDAKRSMNIGIFLKQF
KKSPPSIVEDIHHGKSEHYGSETLREFLKLLPESEEIKKLKTFSGDVAKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDMTILRKATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAVLLNFSEKLLHVQEA
ARLSLDNTEAELHSLFVRTKSLKENIERDRELCQQMEDFLQFALEKLAELEQWKRELQDE
AHTLIDFFCEDKDTVKLDECLQIFRDFCIRFNKAVKDNHDRQVQELRQRQRLKELEQKRR
SWTAGEFG-FGRSS----SENDVELLTKRGAED-L-PPFLC-CRP------ASPSYRP-P
TTRRSRLSLDTMADRELLSFLERST--DGPE-EL-KPSNSSQGCL-------WQVPPDGA
CREPGEPRGQDSSLAHRPR-ALEGQEEAPHSTTAWA-NWLPA-AHPD--DPA--CALRRP
RRSGVSTLRKRNSAPVGLDPVRSSPPLSPLALGIREHELVTGLAQFDLQAPKGPEEPPQL
TGNDCSP----MELVSVGDA-SPPSLGAPNSSPTTPVGRGARVG-PSPVP-------QDG
EAAPYEPRSAAPLSEGSSDPDSQDPGPLFCISDT-SDCSLTLDCSEGANSRPLEGDPG--
EAGDGEGSVSPGAWET---G-GSQAS-SNPICSPTVGAPAAASTPGSGSVSGKSELE---
SCKGG-PPRDRP-ARAREAT-ALRRSSPREAPPLAGPSRAG-------------------
------------------------------------------------------------
---------PARPTT----------------------APAARPGREPP-SPLRSSFRKPS
AKPVRNVPR--PKPEEDKACRSGAQGPDGPGEPPRA-ALAASVPRGPASVPSFARNTVAS
SSRSQRLDSPAP-ARAPGLTRTMSQRQLRVKGG-PEGA-APKDSGA---LRRAGSARTLR
KGSESA-EGPGAGAKTPPKGR----------LKEANHTALGRGLHPLRK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEREQKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-TSGGQEEAPNPPSAQA-HQLAA-AQPE--DPA--SAFPRA
RRQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MELESVGHR-GPQSLSASTSS-LTPMGRDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT-TDCSLTLDCSEGTDSRPRGRDPE--
EGGEGDGSMSSGVEEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDNEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------VAK
SVRTLTTSENESMRKVMPITKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRA--------ST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PSVPSVPHELPRVPSFARNTVAS
SSRSMRTDLPPV-AKAPGITRTVSQRQLRVKGD-PEDA-APKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGRILNPLRK

------------------------------------------------------------
------------------------------------PRPPPPPHTLPGG--------PPA
----PLPLPGLPPTAPLNG

PF02181 // ENSGT00760000118986_0_Domain_2 (140, 205)

FGHLGKKRRMRSFFWKTIPEEQVRGKT--NIWTLAARQQQQ
YQIDSRTVEELFGQQDDG-NKGAP

ENSGT00760000118986_0_Linker_2_1 (205, 277)

SRRGGALNASFREAREEXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

PF02181 // ENSGT00760000118986_0_Domain_1 (277, 338)

IKKLKAFGGDVAKLSLADSFLHHL
IQVPNYSLRIEAMVLKKEFLPNCSALYTDITMLRTAI

ENSGT00760000118986_0_Linker_1_3 (338, 402)

KXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEAH

PF02181 // ENSGT00760000118986_0_Domain_3 (402, 461)

KKDAILLSFSEKLHHVQEA
ARLSLDNTEAELHSLFARTRSLQGSIQHDVELCQQMEEFLQXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDNHERLLQEQRQQQRLKDLEQKRR
SWAVGEL-GFGRSS----SENDVELLGQKGPEDLP--PFLQ-PRP------ASPSSRP-P
NTRRSRLSLATSADRELLTFLEGSSS-RASS-EELKFNSLPRSS-------PRQARPTVA
WMEPEMPGDPHFDRAHRPLTSQAP-EEVPKLTSSQD---QVLAPWPG--GLG--QASP-A
GRRGT-SVLRKHSEPVGLGPRR-SPPLSPLSVGIKEHELVTVLAQFALQPQGP-QET---
---ALASDGSPMELESPGTR-TQESLGVTHSS-PPPGDKGDQGA-PSPAPED-------P
EGPLDEPSSSVLLSGCSSDPEN--KGPMFYISDT-TDCSLTLDFSEGTDGRPD----W--
EGGEGDGSLSSGIGDPGG----SQVS-SNPTSSPAGEPPA----PT----LGKSGPS---
-CKGG-LPRDRP-TKGKDAMATPKRNSLKETTLGA--SKAGGVRRGQ--------AASAK
PVRTLTSWESPSMRKVVPISRGSRASG--GWRPPQAP------------SGSDPPWSRRS
SVKGTSDTSPRRAP------------EEPRLPRA-SGSISARPGREPPGPQSRSAPRKPS
AKPLRNVPRQ-KPPEENKICCPQDPETPEDEEPKTSLPPPVPSAPGPPHVPSFARNTVAS
SSRFLKAE-PSPVSRAPGITRTMSQRQLRVGCP-DEA--SPKD-SA---LRRASSARAPQ
-------------------------------------------------

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPPPCPHSGEGFSPSPPPPLPPP--LPGG--------PPI
---PPPPPPGLPSVSYLNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQHQ
YQIDKKTIEELFGQQEDT-SKASLPKRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEKLQHVQET
SRLSLDITEAELHSLFVRTKSLQENIQLDQELCQQMEDFLQFAVEKLAELELWKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRY
SWSTGELGSFGRSS----SENDVQMLAKTGTEDLP--SFLK-PRP------NSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPTIA
WMEPREQQSHGPNFTHEPQASKIQEK---APPPAWQ-NQLPT-TWRE--EPA--SPLPLA
GRSRPS-LRKRNSEPVGLGPTQ-SPPLLPLDLGVREHELVTGLTQFDLQSPKSLEEGSQL
TLNDFCP----TKLPSPGDR-SSQPFAAGGDS-LPPKDTDTQEV-LSPAGED-----D--
RTISDEPSSEALVSVVVTDTEDKDAGPLLYVSDT-TDCSLTLDCSEGMDSRAGGDKQE--
EEKEGDGSVSSGAGEA---G-SSQVS-SNSVSSPPGEVPA----PK----SSKSELS---
-CQGG-LPKDRP-SRGKDAI-APKRNSFKEASVGA--SKPVSARRSQGV--------TTK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTPK-A-TPRETP-SSTDTPLSRRS
SVRGTSDTSPRRPQVSGS-GA-----EEPRLPRSS-GSISGRPGKDAP-LQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSPDPESPKEEPKA-PQATGVSRALPPIPSFARNTVAS
SSRSLRTDAPPA-ARTTGLTRTVSQRQLRVKGG-SEDS-ASKDIGT---LKRASSARASK
KCPESA-GGSSANVETSLKGRGTTERS-SLRLKDSGQATLGRILRPLQK

------------------------------------MHVMNCVSLVSDKENGTIGPGAGF
MIGQTPPPPPPPPPPP----PPPPCLHSGEGFPPSPPPPPPPP--LPGG--------PPP
---PP-PPPGLPPASHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKRRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-TKSSLSRRGGTLNSSFRDAREEITIVDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKTFSGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAVLLNFSEKLHHVQEA
ARLSLDNTEAELHSLLIRTRSLRENIQRDGELCQQMEDFLQFALEKLTELEHWKQELQDE
AHTLIDFFCEDQETMKLDECLQIFRDFCVKFNKAVKDNHDRAVQELRRLQRLKELEQKRR
SWAAGELGGFCRSS----SENDVEQLTKKGTEDLP--PFLQ-PRP------VSPSYRP-P
NTRRSRLSLGAFADRELLTFLESST--GSPE-EPSKFNSLPRSSP-------RQARPTLA
WMEPGDPKAQDPGQAHRPQASGGRKEDPEPPSSSCQ-SQLSA-LRPE--DPT--PAFPRV
RRSGVSILRKRNSEPVGLGPAR-SPPLSPLALGIKEHELVTGLAQFDLQGPKGPEEVPRL
TANDLSS----RAPVSPGDG-SEPSLSASHSG-LRPVGTGARGG-LSPALEG-----EED
PAAPDEPSGKALVSVGSSDPESKDAGSLFYVSDA-TDCSLTLDCSE----------PG--
EAGAGDGSLSSGAGEP---G--SQVS-SHPTSSPVGEASA----PG----SEESPPA---
-RRDS-LPGDRP-AKGKDAA-AAKRSSVREAPQGA--PKASPARRSQPA--------APK
AVRTLTASESESMRKVVPISRAGRAPGPAGWKRPPREAP-GGRGP-------SDESPRRA
-----------------------------------SAGAGAGPGKEPP-LQPRGSLKKPS
AKPLRNVPR--QKPEENKICRSGPQGPDSPEEEPPA-PPAPSAPRAPPPVPSFARNTVAS
SSRSLRADPPPG-PRAP-VSRAASQRQPRPKGG-PEDA-APRDGGA---LRRASSARAPR
RWPEAA-AAAGAGAEAPPRARAPGDRA-SLRLKPSERAALGRMLEPLRK

------------------------------------MHVMNCVSLASDKENGDISVTAGL
MIGQTPPPPPPPPPPPPPPPPLPPCPFPDAGFAPPLPPPPPPPPPLPGG--------PPA
PP--PPPPGLPPPSPFYNGHGHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 512)

SKKKRMRNFFWKTIPEEQVRGKT--NIWTIAARQQHH
YQIDTKTVEELFGQQEDT--NSPAFRRSGSLNSSFKDAKEESTILDAKRSMNVGIFLKQF
KKSPQFIVEDIHRGKSEHYGSETLREFLKVLPESEEVKKLKAFSGDVSKLSLADSFMYFL
IQVPNYSLRMEAMVLKKEFLPSCSSLYKDMTVLRAATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVALEAQKKDVVLLIFSEKLHHVQDA
ARLSLDNTEAELHSLSARTRCLRENIQRDPELFQQMEDFIQFALKKLKELEQWKQVLQEE
AHTLIDFFCEDKETMKLDECFQIFRDFCTKFNKAVKDNREREVQELRQLQKLKEVEGKRR
SWAAGELGGFGRSS----SENDVELLTKKGLEDFL--PFLQ-QRP------LSPSSRVPA
NSRRSRLSLGTSADRELLTFLETS----TGE-EPNKFNSLPRAS-------ARQARPAET
WMEAQETRDLNSNHVHLDPAPG-PGGSSGNSPPLQP-SLLQDLDEPR--STS--ARLYQA
QNRANANHPQRMGGPGGSAPAS-APARCPLAVEIEERELVGSLIRFDLQGPRGSGEQSGV
TVEDFSP----MELESLEADISLQSFSAADDS-SGPYSPCSRD---TADWKGSGLDQRGV
GAGMSLPTSTTPASLDTSDSESKEPGPVFYISDT-TDCSLTLDCSEGNDVKTADRETE--
DEAA-GGPVLPGSGDPEGEKG-SGLV-SDPNCSSVGEGPA----LF----SGRDEPN---
-SKRGPTGGCRA-AKGRDLV-APKRNSVKDQPASA--PKPGTAPRGQ--------GSVAK
SIRTLNSSENESMRKVVPISKASRGSG--GWKRPEGPG--RGAPREGPSSGPDARLARRS
SVRGTADTSPRRPVGSMVVAI-----EEQRWLRGGPASGATRPGREPP--QRRSSLKKPS
AKPVRNLPK--PKLEETKICRSNSREPEGPEEAAPS-PPVASAPRVPPPTPSFARNTVAS
SSRRLKSD-LPPASKPPSLMRAASQRQLKVKTG-PEDP-GSKESGV---LRRASSARAAR
RGPEPS-ESPGPRGEGPGRARGPPEKP-SHKLKEGSRTTLGKILNPLWK

------------------------------------------------------------
--------PPPPPPPLP-SSPPQQCPYSGEGFPLSP--PPPPPPPLPGG--------PPL
----PPPPPGLPPESHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGNKKRVRSFFWKTIPEEQVRGKT--NIWTLAARQQHQ
YQIDAKTIEELFGQQEDTTTKSSLSRRGGTLNSSFRDAGEEITVLDAKRSMNIGIFLRQF
KKSPQSVVEDILQGKSEHYGSETLREFLKLLPESEEVKKLKTYGGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSGKLHHVQEA
ARLSLDNTEKELRSLVTRTRSLRENIQRDGELGRQMENFLQFAVEKLTELEHWKQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCVKFNKAVQDNHDREVQELRRMQRLKELEQKRR
SWAAGELGGFCRSS----SENDVEQLTKKGTEDLL--TFLQ-ARP------MSPSYRP-P
NTRRSRLSLGAFAEQELLTFLEESST-DGPK-EPSKFNSLPRSSPRQARPSPRQARPTLA
WMEPGDPKAQDPSGAHRPQASE-GQEGAPEPPSSWP-SQQSPAPRPE--DAA--PPLLRV
RRSGVGVLQKRKSEPLGLGPAQ-SPPLSPLALGIKEHELATGLSQLDLQGSKDPEEVPRL
TLNDLSP----VEPVSVEDG-NVQSLGTSCGA-LMPVGTDAPDG-PSPAWEG-------D
GADPEKPSGKALVSVGSSDPESKDPGPLLYVSDA-TDCSLTLDCSEP----------G--
EEGGGDGSLSSGAGE---TG--SQVS-SHPTSSPLGEASA----PV----SGKSQPS---
-CKDS-FPRDRP-AKGKDVT-APKRSSLKEASQGA--SKPASVRRSQGAQGAQ--GTAPK
PVRTLTASENESMRKVLPISKSSRGLG--GWKRPPRET--PIG-----------------
-----------------------TVADEQRLARASVGSSSAKSGKEPP-LQQRGSLKKPS
AKPLRNXXX--XXXX----XXXXXQGPESPEEEPKS-PPPPSVPRVPPPVPSFARNTVAS
SSRSMRTD-SSLVAKAPSITRTLSQRQLRLKSG-PEDA-APKDGST---LRRASSVRTPK
RCPEAA-GAPSANPEAAVKGRGAGERA-SLRLKNSDRSTLGKILGPLRK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPPPCPHSGEGFFPSPPPPLPPP--LPGG--------PLI
---PP-PPPGLPPVAQVNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQQH
YQIDKKTIEELFGQQEDT-SKASLPRRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSEMLREILKLLPESEEVKKLKTFNGDASKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSSLFKDMTILRTATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAKLLHFSEKLQHVQET
SRLSLDVTEAELYSLSVRTKSLQENIQWDQELFQQMEDFLQFAVEKLSELELLKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRLKELEQKRY
SWTTGELGGFGRSS----SENDVQMLANKGTEDLP--SFLK-PRP------TSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPIIA
WMEPREQKNHDPNFAHEPQASQNQEK---APSFAWQ-SQLPT-PQRA--EPA--SPFPLA
RRGRVSILRKRNSEPVGLGPTQ-SPPLLPLDLGIREHELVTGLAQFDLQSPNCLEEASQL
TLNDFCP----TKLQSPGDQ-SSQSFDTVSDS-LTPKDTVPQEV-LSPAGEN-----N--
EAGSDEHSSEALVSVVVTDTEDKDPGPVLYVSDT-TDCSLTLDYSEGTDSRPGGEEQE--
EEREGGGSVSSGAGET---G-SSQ-I-SNPASSPPGELSA----PN----SSKSEPS---
-CQGG-LPKDRS-SKGKDAI-APKRNSLKEASPGA--SKPASVRRSQGA--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPELTSR-A-SPRETP-SSTDTLLSRRS
SVRGTSDTSPKRPHVTGP-GA-----EEPRLPRSS-GSISGRPGKEAP-VQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSEDPESSKEEPKV-PQTPGVSRALPPVPSFARNTVAS
SSRCMRTDAPPA-SRAPGITRTVSQRQLRVKGG-PEDS-ASKDSGT---LKRASSARASK
KCPESS-GGTSANAETPLKGRGTSERA-SLKLKDSGRATIGRILHPLQK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPLP-P-PPPSPTCSYSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTSHVNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITVLDAKRSMNIGIFLKQF
KRSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHNVQKT
ARLSLDNTEAELHLLFVRTRSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQR
SWAAGELGAFGRSS----SENDVELLAKKGVEGLP--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGLSADRELLTFLESST--GIPE-EPNKFHSLPRSSP-------RQARPTIA
CLQPAEARHGDSSFAQKPQ-ASRGQEEAPNPPSAQG-HQLPA-ARPE--DPA--SAFPSA
RRHGISILRKRNSEPVSLGSAR-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEGVSQL
TLSDFSP----MKLESVEDE-GPHSPSAGSSN-LTPMDGNALGS-LSPALED-----G--
KAAPVEPGSVALGSVGSSDPENKDPGPLIYISDT-TDCSLTLDCSEGTDSRPRGGDLE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPASSSPGEAPA----PV----SVDSEPS---
-CKGG-LPGDRP-TKRKDVI-APKRSSLKEASPGA--SKPGSARRSQGP--------APK
PVRTLTASESESMRKVMPISRSSRGAG---WRRPELPSR-G-PSQNPP-SSTDTVWSRRN
SMRRAS--------T----SA-----EEQRLPRGSSSSSSTRPGRDTP-LQPRGSLKKPS
AKPLRNLPR--QKPEENKTCRTHSQGPENPKEEPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSLKTDLPPT-AKVPSITRTVSQRQLRVKGD-PEDA-APKDSST---FRRASSAQVPK
KGPEST-ESPSANTEAPLKARGAGERA-SLRQKDSSRTTLGRILNPLRK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--XXXXXXXXXXXXXXX
---XX-PPPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSYSSLYTDVTVLRTAIKELMSCAELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGADGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGISVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPRSLGHE-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGSAALGSVGSSNPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MSK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVR---------TST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRASFKKPS
AKPLRNLPR--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRKDSSRTTLGRILNPLWK

-----------------------------------KMHVMNCLSLVNDKENGAIPVATGL
MSEDTTTAPQLSQPAA--SPPPAPCPLTGAPPAPPLPPGMPPP---------------PP
PPPPLPGPSIPLPPQLLNGHN

PF02181 // ENSGT00760000118986_0_Domain_1 (142, 512)

SHGKKKRMRSFFWKTIPEEQVRGKN--NIWTIAARP--Q
YQIDTKTIEELFGQQEEA---KPQDSRNRSLKSSFKETKEEVSILDAKRSMNIGIFLKQF
KKSAESIIEDIYHGRSQPYDPELLREFLKLLPEAEEVKKLKAFDGDISKLSQADSFMYLL
IQVPNYALRIEAMVLERQFSPSCASLQDDMKIIRQATKELMTCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMTLLHFVALEAQKKDAALLNFSEKIRSVHDA
ARLSIDSVEAELHSLSAKTRYVKDSIRRDPKLSHQMEDFLQFAVKRLQKLEDQKQELQKE
GNALIDFFCEDKETMKLDECFQIFRDFCIRFNTSVKENTEREIQELQSLQRRKELEEKRR
SWAAGELGSCGRSS----SENDVEMLAKNGLGEFL--PFLQ-QRP------QSLLYRN-T
NSRRSRLSLGMTADRELQSFLEISK----DE-DPNKFNSLPRAN-------TRQTKPNVA
WTESKETRDLNLNTLHLHQQSKMEV-KSGGPVQVPP-GQPSHLRV----SASP-GAHYSQ
RSTDYSL--HT-----SNVSCGESTDVNALALAIEERELVKGLRKFDIQGAKHAEDAPLK
YLEDAGG----TDLETLDDL-SFHSLSTADDEL-PPACRSSREARDHQ---A---KAVRC
KNEALEASSSSPMSMDTSVSGSREDGPVCYMSDTTTDCSLTLDSEEGNDFKSAGSEIRIE
AGK-----ACSSGNDAQHKA--RSSF-SNLNSTSDKGLSL----------HTSANDKDDA
DSKHI-LPKEKP-IKNKDLV-GPKTNSLKDRSLSS--TKSSGTRPSHTA--------PSR
PVRTLNASENESMRKVVPISRSNRA--PSSVKKPEAKPALRE------SSTVENRLSHRS
SVRGTTDTLPRSPYRHSM------SVEEPRIRRGTVTSSSAHFERDR--VA----LKKPI
SKPIKSNVK--SKTDETKMCRSSVKPQTPPDDTKVA---TVTIPKAPPAVPNFARNTVAS
SSKRAKVD-LSSSSRPPPITRSVSQRLPKVKPAVTSDDPNPKENS-VRTLKRANSARVVG
RSILQG-EAVSMKAEPAPKEQETVEKA-SLKLKDANRNTIGKILKPLLK

------------------------------------------------------------
MVEQPPPPPPQPPPPP-PPPPPPPLPFQ----------NVPPPPPLPGA--------PPP
PP---------LPHQVGNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

HGNNSKRNRMRSFFWKTIPEEQVRGKN--NIWTMAAKQ-QQ
YQIDTKTIEELFGQKEEP--RSGLIKAKGNLKSSFREAKEEVSLLDSKRSMNIGIFLKQF
KKSTEEIIGDIREGRCDLYGPEPLQELLKLSPESEEIKKLKAFSGEVAKLSLADTFMYLL
IQVPNYSLRIEAMVLRKEFGSCHSALKNDMTVIRVATKELMSCEQLHSILFLVLQAGNIM
NAGGYAGNAVGFKLSSLLRLADTKANKPGMNLLHFVALEAQKKDVSLLTFSEKLPSVGEA
ARLSIDNMEAEFKSLSTKTKSIKDQIKKEPELYKQMEDFLKDAVKDLKDLESLRAEIKKE
CHTLIDFFCEDKETMKLDECFQIFRDFCDKFNKAVKENREREIQDLRKQKKLNELEQKRR
SWVASENANFGRSS----SENDVEILTKAGLED-----FLQ-QRP------QSSLNRN-S
STRRSRLSLGVAADRELQMYLGASQ---VEE-TTSKFNSLPRSH-------THKPRPTVA
WIDSKVEKDHSLNILHLKNETR-DTQQ--QIPSSLVITSLEDDQSIH--TAN--NSVQQQ
QEKADRNNNKAELHKYGIDLKQ-HSSVSPLAVTVEEHELVKKLQQFDLSGTVCENYEQLY
NTE-----------EETNDGLSLCSFSSTDDN-TIPPSKNNNEN-FKASDSISNSYG-DR
KLSEDLLNVSTTISERTGTAEITEHTPQFCVADT-TENSLMLDATGGTDLLSETEEIE--
IIQKV----NSNDG----KKKLNPVA-KIP---------------V----SGKPESTDHN
AKKAG-LTKETT-LKNKDN--LRKTSSIKERFPST--IKSSIN------NSSN--TVSTK
PVRMLNDSEHENMRKVVPISKSNRSG---SIKRTELRSS-LRD-----SNSSDSKQTLRH
SFRGKSENLPKNSSK----------TEEPKLQRGDSFISSGSRFQRDQ-LQRNNSVKKPA
AKPVRNIAK--PKPEETKLCRTTAKLSSSTEASKVPPALPMKSPSSSSSTPSFARNTVAS
SKRAK-TD-PAPPTKVTTMSRSGSLRQSKTKSD-LSKNGNTKDDGTVNTPKRANSLRANG
RLFEPVR---DSLPESDQKEKSIVEKS-SMKLKDTGKATLGKILKPLLK

------------------------------------------------------------
------------------------------------------------------------
----------------------------

PF02181 // ENSGT00760000118986_0_Domain_2 (149, 276)

MRSFFWSTIPEEQVRGKA--NIWTLGAGGQHH
FQIDTKTIEELFGQQEDT-PRPSLPKRGGPLSSSFKDMREEITILDAKRNMNIGIFLKQF
KKSPQCIVEDIHQGKSEEYGSETLREFLKLLPKSEE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPPPCPYSGEGFSPSPPPPLPPP--LPGG--------PLI
---PP-PPPGLPPVAHVNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRLRSFFWKTIPEEQVRGKT--NIWTLAAKQQHQ
YQIDKKTIEELFGQQEDT-SKASLPKRGGALNSSFRDAREEITVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSTLFKDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAALLHFSEKLYHVQET
SRLSLDVTEAELHSLSVRTKSLRESIRRDQELSQQMEDFLQFAVEKLSELELWKRELQGE
AHTLIDFFCEDRETMKLDECFQIFRDFCTRFNKAVKDNRDREEQERKQLQRLKELEQKRH
SWTTGELGGFGRSS----SENDVQMLARKGTEDLP--SFLK-PRP------ASPSCRP-P
NTRRSRLSLGISADRELLTFLESSTS-SSPE-DPNKFNSLPRSSP-------RQTRPIIA
WMEPREQQNHDPNFAHKPQASENQER---APHFAWQ-SQRPT-PQRE--EPA--SPFPLA
GRGRVSILRKRNSEPVGLGPTQ-SPPLLPLDLGIREHELVTGLAQFDLQSPKSLEEASQL
TLNDFCP----TKLQSPGDQ-SSQSFDAGSDS-LTPKDTGPQEF-LSPAGEE-----D--
GPVSDEHRSEALVSVVVTDTEDKDPGPPLCVSDT-TDCSLTLDCSEGTDPRPGGEEQE--
EEREGDVSVSSEAGEA---D-SSQ-I-SNPASSPPGELSA----PN----SSKSEPS---
-CQGG-LPKDRP-SKGKDTM-APKRNSLKEASPGA--SKPVSARRSQGA--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTSR-A-SPRETP-SSTDTLLLRRS
SVRGTSDTSPRRPHVNGP-GA-----EEPRLPRSS-GSVSGRPGT--P-VQPRALLRKPS
AKPLRNIPR--QKPEENKVSSPNSKDLENPKEEPKA-PQTPGVSRALPPVPSFARNTVAS
SSRCVRTDAPPA-SRASGITRTVSQRQLRVKGG-SEDS-ASKDSGT---LKRASSARASK
KCPESS-GGSSASAETPLKGRGTAERA-SLRLKDSGRATLGRILHPLQK

------------------------------------MHVMNCVSLGSDKENGNIATAGGF
MIGQTPPP--------------APCPFSGEGFLSSPPPPPPPP--LPGG--------PPV
---PP-PPPGLPPPSHVNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-TKSPVSRRGGALNSSFRDAREEITILDAKRSMNIGIFLKQF
KKSPQSVVEDIHQGRSEHYGSETLRELLKLLPESEEVKKLKAFSSDVSKLSLADSFMHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITMLRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKSNKPGMNLLHFVAQEAQKKDVILLNFSEKLHHVQEA
ARLSLDNTEAELHSMFVRTRSLKENIQRDRELCQQMEEFLQFAVEKLTELEHWKQRLQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCTKFNKAVKDNQDREVQELRQQQRLRELEQKRS
SWMAGDLGGFGRSS----SENDVELLTKKGTEDLP--PFLH-PRP------ISPSYRP-P
NTRRSRLSLGAFADRELLTFLESSV--SSPE-ELTKFHSLPRKSN------PRQAQPTVA
GLEAGNL---SSKLTHRPQ-ALEGRVEAPSPSTVWQ-SQLSA-PRPG--GPD--SAFPRA
GRSGVSILRKRHSEPGGLAPSR-SPPLSALVLGIEEHELVTGLAQFDLQGPKGPEEMSQL
PLHDVSP----LKQASLQDG-HLQALDTGNRS-LTPGGRGSWEG-LGLALED-----D--
RAAPDQPSSVAQVSVGSGDPEDKDAGPLFCISDT-TDCSLTLDCSEGTDSRPGGRDPE--
ESGDRDGSVSSGAGET---G-GSQVS-SNPASSPPEEAPA----PV----SQKSEPS---
-CKHG-PPRDRT-PRGKDVL-APKRSSLKEASPGA--PKPGSARRSPGA--------IPK
PVRVLHASENESIRKVVPISKSSGGPG--GWKRPEPAPR-GAPS------STDTLLLRRG
SMRGTSDTSPRRPAAVAVATT-----PEEQ---KLQRFSSTRLGKEPP-LQHRSSLKKPS
AKPLRNVLR--QKPEENKVCRSSSQGPESPEEDPKT-SPAPSLLRVPASVPSFARNTVAS
SSRSMRTDSLPV-TKAPGLTRAVSQRQLRVKGG-PEDT-FPKDSST---LRRASSTCTPK
KCPESA-EGPSANTEAPLKGRAVGKRA-SLQPKGSNRTTLGKMLNPLWK

------------------------------------MHVMNCVSLVGDKENGNIATAAGF
MIGQTHPPASPPASL-P-PPPSLPCPNSGEGCSSSPPPPLPPPP-PPGG--------PPV
---PP-PPPGLPPTSHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_2 (144, 241)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-TKASPSRRGGTLNSSFRDAREEITILDAKRSMNIGIFLKQF

ENSGT00760000118986_0_Linker_2_1 (241, 284)

K------------------------------------------

PF02181 // ENSGT00760000118986_0_Domain_1 (284, 511)

NGDVSKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILKTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQET
ARLSLDNTEAELHSLFVRTRSLQENIQRDGELCQQMEDFLQFAIEKLTELEHWKQELQDE
AHTLIDFFCEDKETMKLDECFQIFRDFCTKFNKAVKDNHDRELQELRQLQRLKELEQKRR
SWASGELGAFGRSS----SENDVELLTKRGAEDLP--PFLR-PRP------ISPSYRP-P
NTRRFRLSLDTAADRELLTFLESAT--RRPE-EPTKFNSLPRSSP-------RQPRPTLA
WMEPREPRDHDSNFAGKPQ-ASEGQEKASSPPSAWQ-RQPPA-SRLE--DPA--SALLRV
QRKGVSTLLKRNSEPVGLGPRQ-CP--SPLALGVKEHELVTGLAQFNLQGSQALEDTAQL
TSSDSSP----VEMESLGDG-SPQPLSASNGS-LAPTDRGAQGRSLSPAPGD-------G
RAAPDQPSHAAPVSMDGSDSENKDLGPVFYISDA-TDCSLTLDCSEGTDSRPGGGEPQ--
EGGQGEVSMSSGTGEM---G-GSQVS-----SSPAEEMPA----PG----SVKSEPS---
-CKSG-PPRDRS-VKGKDVT-TPKRNSFKDASLVA--SKPGSARRSLGA--------APK
SVRTLTASENASMRKVVPISRSSRDSG--GWRRPEPSSRV--LPREPP-SSTDTPWSRRS
SS------------------------EEQRTPRWS-GSSSARPGREPP-LQHKGSFKKPS
AKPLRNVPR--QKPEENKICCPSSQGLESPKEEPKT-PPAPSVPRAPTSVPSFARSTVAS
SSRSMRPDPLPG-ARTPGISRTVSQRQLRVKGG-PEDT-FLKDSGT---LRRASSARSPK
KGPEST-EGPSANTESPLKGKGDGERA-SFRQKDSSRTSLGKILTPLCK

------------------------------------MRVMNCVSLASDKGNGNIAAAAGF
MIGQTSPSSPPTPPPPP-PAPPLPCPHSGGALSSCS--PP--------------------
-PPPPPPPGGPPLTPHLDTFGSLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 511)

KKKRMRSFFWSTIPEEQVRGKA--NIWTLGAGGQHH
FQIDTKTIEELFGQQEDT-PRPSLPKRGGPLSSSFKDMREEITILDAKRNMNIGIFLKQF
KKSPQCIVEDIHQGKSEEYGSETLREFLKLLPKSEEVKKLKAFSGDVAKLSLADSFMHRL
IQVPNYSLRIEAMVLKKEFLHACSSLYTDITILRSATKELMSCEALHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDSILLHFSGKLCHVQEA
SRLSLDNTEAELKSLTLRTKSLEENIKRDGELYQQMADFLQCATAKLVDLEQWKEKLQSE
AHTLIDFFCEDKETMTLDECLQIFRDFCTKFNKAVKDNQEREVQESRQQQRLRALEEKQH
SWAAGELGGFIRSS----SETDMQLLTHKGTEDLA--LFLH-PRP------DSPSARP-P
NTRRSRHSLGFSADRELLSFLES-AT-GGLE-E-PKFNTLPGRG-------RRLARPTLA
SMQPGGAGDCHPTSPHRPPKAP-DVPQP------------------A--EQT--GAVPRA
WH-QAGGLQKRSSEPGGLGAAG-SPPLPSLALGVKEHELVTGLARFSLGDPKGSQETALN
TPNEV----------IPGPG-SPRSPSYSTTA-A---DKGPREA-PSQAPEA-------E
AATPHEPGS---QALGPAGSGDLEHGDHLSVSDA-TDCSLTLDCSEESSEPGRLEDGA--
WP-----------EA---EGR-SPAS-PMPASS---EASA----TD----SAPSEPG---
-RKGG-RARDRP-APAKEAP-VPRRGSGREAP--R--ERPGGGRRGQ--------GTEPR
PVRTLTASESQGLRKVVPLAKGGRGAR--AGKTPEPPP--ARN----P-P-REAAPARSG
SLKGTQDAG-----------PE----E-QRVPR-GGG--NARPGKESP-LQPKGSVRKPS
AKPLRAVPR--PKPEE--------------PLSPED---KPRPAA--PSVPSFARNTLAS
ASRCVRPE-PA--PRGPGLMRTASQRQLRAKGG-PEDT-----DST---LRRTSSARVPR
RSSEAG-EGPGAGAEAPSK-SRAGERG-APRQQGPARTALGRILEPLWK

------------------------------------------------------------
------------------------------------------------------------
----------------------------

PF02181 // ENSGT00760000118986_0_Domain_2 (149, 276)

MRSFFWNTIPEEQVRGKA--NIWTLAAQEQHH
FQIDTKTIEELFGQQEDT-PKPSLPKRGGPLSSSFKDARDEVTILDAKRNMNIGIFLKQF
KKSPQSIVEDIHQGKSEDYGSETLREFLKLLPKSEE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MRVMNCVYLASDKENGNIAMAAGF
MIGQTPLPAPPPP------PPPPPCPYSEQGFAPSPPPPPPPP--LPAS--------GPP
---GPPPPPGLPPAPHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSQAGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAASQQQH
YQIDTKTIEELFGQQENT-AKPSASRRGATVSPSFREAREEITLLDSKRSMNIGIFLKQF
KKSPPSIAEDIHRGKTEHYGSETLREFLKLLPEPEEVKKLKDFSDDV-KLSLADSFLYHL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILKTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLKFSEKLHHVKET
ARLSLDSTEAELHSLFVRTSSLRDNVRRDRELCQQMGDFLQFAMEKLTELEHWRQELQAE
AHTLMDFFCEDRETMKLDECFQIFRDFCLRFNKAVQDNHDRELHDLRQQQRLKDLEQKRR
SWVSGDLGGFGRSS----SENDVELLTQKGAEELP--PFLH-PRP------NSPSSRP-P
NTRRSRHSLGLSADRELLTFLESSM--AGSE-EANKFNSLPWSSP-------RQARPSMA
WMEQAEPRRHNSTSTPKAE-VSKNQEEAPSPPARWT-SHPPA-PRPE--EPAP-ALLQGT
RHSGGSILRKRNSEPMGMGPVL-SPPLSPLALGIKEHELVTGLAQFNLQGRQGREDASRL
SPSDLKP----LEPESGAPR-SPQPLDAGA---------------------Q-----EDS
GAAPAEPCSEALGPLESSDPESKDPEPLLYISDA-TDCSLTLDCSEGTDSRPPSGAQREE
AGAVGGGSMSSGVGET---PPDSQLSSSNPASSPTREASA----VA----SVKNEPS---
-AKGG-LTRDRAISKAKEGV-TPKRIPLKEATPSI--SKPASARRVPGA--------TAK
PVRTLHATESETMRKVVPISKANRGVA--STKRPEPSAVARAPVRDSP-GSTDAAR----
SVKDSLDTSARRPSTGGA--------EEQRPLRGS-SSSSARPMXXXX-XXXXXXXXXXX
-------------XXXXXXXXXXXXXXXGLDSEP-----PTPVPPAPQPVPSFARSTVAS
SSRSTRTEPPTGSSKVPGLTRTMSQRQLRVKGA-PEDD-ASKDSSP---LKRASSVRPAK
KGPDSA-EA-------PGKGKGAGERA-SFRLKGSTGSTLGRILEPLWK

------------------------------------MHVMNCVSLANDKENGTLATAAAF
MTGQTSPSASPPPPP---PPPPPPCPHSGEGFSSSPPPPLPPP--LPGG--------PLI
---PPPPPPGLPPVAHVNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQRH
YQIDKKTIEELFGQQEDT-SKASLPRRGGSLNSSFRDAREEVNVLDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSEMLREMLKFLPESEEVKKLKTFNGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYQDITVLRTATQELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTRANKPGMNLLHFVAQEAQKQDAILLHFSEKLQHVQET
SRLSLDVTEMELHSLFARTKSLQENIQRDQELAQQMEDFLQFAVEKLSELELWNRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEHERKQLQRLQELEQKRH
SWTTGELGGFGRSS----SENDVETLAKKGTEELP--SFLK-PRP------TSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--GSPE-DPNKFNSLPRSSP-------RQVRPTIA
WMEPSEQQNHDPNIAHEPQASKKQEK---TPRLAWQ-SQLPT-PRLE--EPA--APFPPT
GRGRTSILRKRNSEPVGLGPTK-TPPLLPLDLGIREHELVTGLAQFDLQSPKGLEEASQP
TLKDFCP----TELLSPEDQ-SSQSLEAGGDS-LTPRDTGPQEG-LSPAGED-----D--
GAVSNEPSSEALVSVVVTDTDGKDPWPPLYVSDT-TDCSLTLDCSEGADSRPVE-EQG--
KEREGAASVSSGAGEA---G-SSQTF-SNPASSPPEEVPA----PN----SSKSEPS---
-CQGG-LPKDRP-SKGKDIT-ALKRNSLKEPSPGA--SKPINARRSQGA--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTSR-A-SPRETP-SSTDTLLSRRS
SVRGTSDTSPRRPHVSGP-GA-----EEPRLPRSS-GSMSGRPGKEAL-GQPRASFRKPS
AKPLRNIPR--QKPEENKVNSSNSQDSESPKEEPKA-PQASGVSRTLPPVPSFARNTVAS
SSRCMRPDAPPA-SRATGITRTVSQRQLRVKGG-PEDS-ASKDSGT---LKRASSARTSK
KCPESS-GGSSANAETPLKGRGTGERS-SLRLKDSGRATLGRILRPLQK

------------------------------------MHVMNCVSLASDKENGTVSTASGF
MIGQTPPPPPP-------PPPPLPLPCPGEGFPPSAPPPPPPP--LPGG--------TPV
---PP-PPPGLPSTSHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YNHLGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTVEELFGQQEDT-TKPSLSRRGGTLNSSFREAREEITVLDAKRNMNIGIFLKQF
KKSPQSIVEDIHQGKTEHYGSETLREFLKLLPESEEIKKLKTFSGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLKTATKELMSCEELHSILH-VLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLNNTEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLMELEHWKQELQEE
AHTLIDFFCEDKETMKLDECLQIFRDFCIKFNKAVKDNHDREVQELRRLQRLKELEQKRR
SWAAGELVGFGRSS----SENDVELLTKKGAEDLP--PFLH-PRP------ISPSYRP-P
NTRRSRLSLGTSADRELLTFLESST--GSP--EEPKFNSLPWSSP-------RQARATVA
WMETGEPRDQDCSHTHRPQ-ASEGQEGTPDPPSARQ-GQLPA-PQPE--EPA--PVLLRA
RRSGLSMLRKRNSEPVGLGPAW-SPPLSPLALGIKEHELVTGLAQFDLQCCKDPQSTQLM
T---FGP----VDLHSLVDG-SQPLTA-GNG------STGAQES-LSSAPES--------
--------DGAAPGEPSSDPENKDPGPPFYISDT-TDCSLTLDCSEGTDSRPGGGETG--
EGGEGDGSVSSGAGET---G-GNQVS-FNPASSSPGEAPA----SA----STKSGPS---
-CKGG-HSRDRP-AKGKDMI-APKRSSLKEASQGA--PKSGTLPRGQGA--------VPK
PVRTLTTSESESMRKVVPISRASRGGS-GGWKQTPREPP-SGEDA---------PWSRRS
SVRGASDTGAE---------E-----QRPR---ARVGSGSARPGK-DA-LQHKGSLKKPS
AKPLRNVPR--QKLEENKFCRSNSQGPQSPEEEPKP-PPAPSVPRVAPQVPSFARNTVAS
SSRCMRTDCPPV-TKAPSLTRAASQRQLRVKGG-PEDA-VPKDSGT---LRRAGSARAPK
KCPESP-EGPGANTESPLKGRGTGERA-SVRLKDSSRTTLGKILNPLWK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MAGQTSPSASPPPP----PPPPPPCPHSGEGFLPSPPPPLPPP--LPGG--------PPL
---PP-PPPGLPPVSHVNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRLRSFFWKTIPEEQVRGKT--NIWTLAAKQQHH
YQIDKKTIEELFGQQEDT-SKASLPRRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGAETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYNDITVLRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLHFSEKLQHVQET
SRLSLDVTEAELRSLFVRTKSLQENIRRDQELSQQMEDFLQFAVEKLSELELWKRELQDE
AHTLIDFFCEDRETMRLDECFQIFRDFCIRFNKAVKDNRDREEQERKQIQRLKELEQKRH
SWTTGELGGFGRSS----SENDVQMLGKKGTEDLQ--SFLK-PRP------ASPSYRP-P
NTRRSRLSLGISADRELLTFLESATSSSSPE-EPNKFNSLPRSSP-------RQPRPTIA
WMEPREQQHCDPSFGHDPQAAKNQEK---APRFAWQ-SQLPT-PQPE--EPA--SPSPLT
GRGRASILRKRNSEPVGLCPTQ-SPPLLPLDLGIREHELVTGLTQFDLQSPRSLEEASPL
TLDDFCP----PKLQSPGDQ-RSQSFDAGGDS-LTPKDTGPQEV-LSPAGED-----D--
RAVSGEPSSEALVSVVVTDTEDKDPGPLLYVSDT-TDCSLTLDCSEGTDSRPGGEELE--
EDRAGDVSVSSGAGEA---G-SSQ-I-SNPASSPPGEVPA----PD----SSKSEPS---
-CQGG-LPKDRP-SKGKDAT-APKRNSLKETSPGA--SKPVSARRSQGV--------APK
SVRTLNSSENEHMRKVVPISKSSRGAG--AWKRPEPTSR-A-SPRETP-SSTDTLLSRRS
SVRGTSDTSPRRPHVSGP-GT-----EEPRLPRSS-GSMSGRPGKEAV-VQPRASFRKPS
AKPLRNIPR--QKPEENKVSSLTSQDPESLMEEPKA-PQTPGVSRAHPHVPNFARSTVAS
SSRCMRTDAPPV-SRASGITRTVSQRQLRVKGG-PEDS-ASKDSGT---LKRASSARASK
KSPESS-GGSSANAETPLKGRGTAERS-SLRLKDSGQATLGRLLRPLQK

------------------------------------IQVMNCVSLLSDKEXXXXXXXXXX
XXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXX--XXXXXXXXXXX--------XXX
------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX

PF02181 // ENSGT00760000118986_0_Domain_1 (208, 484)

XXXXXXXXXXXXXXITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGAETLREVLKLLPESEEVKKLKTFSGDVSKLSLADSFMHCL
IQVANYSLRIEAMVLKKEFLPSCSSLYTDITFLITAIKELMSCDGLHSVLHLVLQAGNIM
NAGGCAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDVTLLNFSEKLHHVQEA
ARLSLDSTEAELHSLSVRTRSLRENIQQDGELCQQMEDFLQXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDNQDREQQELRQVQRLRELERKRR
TWATGELGGFGRSS----SENDVELLTKKGAEDLP--PFLQ-SRP------ISPSYRP-P
NTRRSRLSLGTSADRELLTFLES-TT-GCPE-ELTRFNTLPRSS-------GRQAPPKVP
WVEPGDRH---PNRAYGPQASEEALEEAGSLPSTWQS-Q-RTAWHLQ--DAS--TTFPLA
RRGGVSVLLKRNSEPLGLGQA--SPPLSPLVLGIEEHELVTGLAQFNLQVPKGPEEMPQA
ALNGGSPGGSPGELASLCNG-NLQAQDAGGCS-LSPRSRAAPGS-LGPVLEA-------G
EDAPDPPSSVALGSVESSDSENKDLVPQIYISDT-TDCSLTLDCSEGTDARPGDGEPG--
EAGDQHSSVSSGAGEMAG----HQLS-SNLASSPGEAAPT----PA----SRKSEPS---
-CKGG-LPRDGV-PKGKDVM-APKRSSLKEASLGA--AKPSSGRRGL--------GALPK
PVRTLHATENESMRKVVPISKSTRGSG--GWKRPELPS--RGT------PSSTDTPVRRN
SVRGSLDRR---ASLGNVVAV----REEQKPPQ---VGSSGRLGKESP-LQLRSSFKKPS
AKPLRNMTP-RQKLEENKFCCSNSQGAESPEEEPKI-PPTPSFPRTPASVPSFARNTVAS
ASRCMKTD-ALHVPKALGLTRTVSQRQLRVKGG-PEDT-SPKDSGS---LKRASSARVAR
KGPELP-EGPIANTQAPLKGRGQGEMA-SFRLKESSRTTLGENMNPLRK

------------------------------------------------------------
-----------------------MPPSRGTPGSAA-----------------------AP
AAPPLPGPSLPLHPQLTNGHDGH

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

SRKKRMRSFFWKTIPEEQVRGKT--NIWTIAARP--Q
YQIDTKTIEELFGQQEET---KPPDSRSRSLKASFKETKEEVSILDAKRSMNIGIFLKQF
RKSAESIIEDIYQGRSEPYASELLHEFLKLLPEAEEVKKLKAFDGDVSKLSQADSFMYLL
IQVPNYALRIQAMVLEREFSPSCASLQDDMKIIRQATKELMTCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMSLLHFVALEAQKKDAALLNFSEKIRDVHEA
ARLSIDNVEAELHSLSFKTRSVKDSIRRDPKLFHQMENFLQFAVRHLKELEHQKQELEKE
GNALIDFFCEDKETMKLDECFQIFRDFCLRFNKAVKENREREIQELHHLQRRKELEEKRR
SWAAGELGSFGRSS----SENDVEMLAKKGLEEFL--PFLQ-QRP------QSPSYRN-P
NSKRSRLSLGITADRELQSFLEISK----EE-DPNKFNSLPRAN-------TRQVRPNVA
WTESKETRDPNLNTLHLHQQSETKG-KSSDLLQLRP-AQSSHFGG----STST-GAHYPQ
RSTNCNV--PA-----SNASCEESADINALALAVEEHELVKGLRKFDIQGAKPAEDTPLI
YLEDVGG----TDVETLDDL-SLHSLSTADDDL-PPACRSSRDTHNHK---G---KAVGC
KSEASEPGSSSPVSMDTSISGSREDGPMFYVSDTTTDCSLTLDSEEGNDFKSAGNEVRSE
AGK-----TRSSVNGAQYRP--RTLF-PNLNSA-AKDPSL----------HASTNDKDDA
NSKHM-LSKEKS-VKSKDPV-GPKRNSLKDRSPSS--SKSSGTRPSHTA--------SSR
PVRTLNASENESMRKVVPISRSNKA--PSSVKKPEAKPALRE------ASTVESRLSRRS
SVRGTTDTLPRSPYRHSM------SVEEPRLQRGTVTSSSAHFERDR--VA----LKKPG
SKPVRNTAK--SKMDEAKMCRSSVKPQTPVDDTKVS---PVSAPKAPSSVPSFARNTVAS
SSKRAKVD-LSTSSKPPSITRSVSQRLPKVKPAATSDDLSPKENG-GSTLKRANSARVFG
KSIVQG-DTVSTKAESSPKEQGTVEKS-SLKLKDANRTTIGKILKPLLK

------------------------------------------------------------
------------------------------------------------------------
---------GLPPPSHMNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHD
YQIDTKTIEELFGQQEDT-TKSSVSRRGGTLNSSFRDAREEITILDAKRNMNIGIFLKQF
KKSPQSIVEDIHQGRSEHYGSETLREFLKLLPESEEVKKLRTFSGDASKLSLADSFMYYL
IQVPNYSLRIEAMVLKKEFLPSCSCLYTDMTVLRAATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKSNKPGMNLLHFVAQEAQKKDAILLNFSEKLYHVQEA
ARLSLDNTEAELHSLFVRTRSLKENIERDRELCQQMEDFLQFAIEKLMELEHWKQELQAE
AHTLIDFFCEDKETMKLDECLQIFRDFCTKFNKAVKDNQDREVQELRQRQRLRELEQRRC
SWAVGELGGFGRSS----SENDVELLTKKGAEDLPA--FLH-SRP------ISPSYRP-P
NTRRSRLSVGTCADRELLTFLESST--GSPQ-ELTNFNSLPRKSS------PWQAQPIAA
WTEPRPQ----SKLEHRS-QALEGQVDTPSPPSVWQ-SQLPA-PEPG--DPG--SAFLRA
RHSGSSTLRKRNSEPVGLGPGR-SPPLSSLALGIKEHELVTGLARFDLHSPKGPEEMAQL
ALHDISP----VERAPLQDG-RPQSLSTSSHS-LTPRGRSSRDS-FGPALGD-----D--
RAATDQPGSGVQVSVGSSDPENKDAGPLFYISDT-TDCSLTLDCSEGTDSKPGVGEPE--
DTGDRDGSVSSGAGET---G-GSQFS-SNPASSPAEEALA----PV----FQKSEPS---
-CKVG-LPRDRT-PKGKDVT-APKRSSLKEASPGA--PKPGNARRSLGA--------VPK
PVRTLHTSENESMRKVVPISKSSRGPG--SWKQTEPPAQ-GAPSG-------TDTLLRRS
SVRGTCPGGPLWGQW-----P-----QCQR----SRGSSSIRLRREPP-MLHRSPVKKPS
AKPLRNVLR--QKTEENKTCRSNSQDPESSEEEPKT-PLVPSLPRVTASVPSFARSTVAS
SSRCLRTDSPPV-TKAPGLTRAASHRQLRVKGGDPEDA-PPKDSGN---LKRASSTRAPK
KCSESA-EGPSASAEASLKGRGVGERG-SFR-------KSGKILHPLWK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFIRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGSAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SLDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRTST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRSPSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLASDKENGTVATAAGF
MIGQTAPPASPPPPPP----PPPPCLPSGEGFSPSP--PPPLPPPLPGG--------PPI
PPPPPPPPPGLPPTSHMNGYST

PF02181 // ENSGT00760000118986_0_Domain_1 (143, 511)

LGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-ARSSLPRRGGSFYSSFRDSREEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPESEEVKKLKTFNGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDIAILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAVLLNFSEKLHHVQEA
ARLSLDNTEAELRSLFVRTRSLQENVQQDGELCQQMEDFLQFAMEKLSELEHWRRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDRELHEQRQLQRLRELEQKRR
SWTAGELGGFGRSS----SENDVELLAKKGTEDLP--PFLQ-PRP------ISPSYRP-P
NMRRSRLSLGASADRELLTFLES-TT-DSSE-GPNKFNSLPRNS-------ARQPRPTMA
WMGPREPKDPDPDFTPTPPASE-GLEKAPNPPSAWQ-SA-------P--QAA--EPVPRA
RHEGVGVLRKRNSEPAGLRPAP-VPALSPLALGVKEHELVTGLTPFDLQGAEAPLPTSPL
TPSDL----------SP--G-EQEPPGRGSDS-PTPVDEAPQES-LDAAPEG-------A
GA----AAE---ESVGSSDPESQDPGRLFYISDT-TDCSLTLDCSEGAEPRPG--DGE--
RE-----------------G------------------------SD----SV--------
--------------------------------------SSGAGDLGP--------CQAPA
PASP----------------KAGLGCK--AG------------------------PPRDR
ALRGKDAAA----------TPK----RGSLKEA-SPG--VPKPAEAAP-LQRRGS-LKPS
AKPLRNIPR--PKPEDSKLS-------SS--ESPAD---EPGAPRGPAPIPSFARNTVAS
SSRCLRTD-VPPAAKARAITRTVSQRQLKVKGG-PEDA-GP-RDGT---LRRASSARAPR
KCPESP-EGPDADSPLKA--RGARDRT-SLRLKDAGRATLGRILHPLQK

------------------------------------MHVMNCVSLVSDKENGNVASAAGF
MIGQTPPPP-----PPP-PPPPPPCPYSGEGFLPSP--PPPPPPPLPGM--------PPV
----PPPPPGLPPASHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRNFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDT-TKPSLSRRGGTLNSSFRDPKEEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKTFSGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLDNTEAELRSLFIRTRSLRENIQRDGELCQQVEDFLQFAVEKLTELERWKQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCVKFNKAVKDNQDRAVQELRQLQRLKEREQKRR
SWAAGELGGFCRSS----SENDVELLTKKGTEDLP--PFLQ-PRP------VSPSYRP-P
NARRSRLSLGAFADRELLTFLES-ST-GSPE-EPSKFNSLPRSS-------PRQARPTLA
WMEPGGPRAQDPSHARRPQASQ-SQEEAPEPPSSWQ-SQ-LPVPRPE--DPA--PLFPRA
RRSGVGILQKRNSEPMGLAPAR-SPPLSPLALGIKEHELVTGLAQFDLQGPKGPEEVPRL
TLNDFSS----VEPVSLGDG-SMQSLAASHSG-LLPVSSSAPGG-LSPALQG------ND
GSVPDQPSGEALVSVGSSDPESKDPSPLFYISDA-TDCSLTLDCSEP----------G--
EGGGGDGSLSSGAGE---TG--SQVS-SHPPSSPPGEASA----PL----SGKSEPS---
-CKDA-LPRDRP-AKGKDAT-TPKRSSLREASQGT--SKAVSARRSQ--------GAAPK
PVRTLTASESESMRKVVPISRSSRSSV--GWKRPPGDT--P------S-SPAQQQWSRRS
SVRGTSDVSPRRPSTGAVTVPE-----EPKLARGSSSSGSVRPGKEHP-LQPRGSFKKPS
AKPLRNVPR--QKPEENKICRSNSESPE---EEPKA-PPPPSVPRVPPPVPSFARNTVAS
SSRSMRTD-SPPVAKAPGITRTVSQRQPRPKGS-PEDA-IPKDSGT---LRRASSARAPK
KCPESA-GGPSANTETPPKGRGAGERA-SLRLKNSDPTTLGKILDPLRK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-APPGPPSTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYSL
IQVPNYSLRIEAMVLKKEFLPFCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NEGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQNE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREAQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARPPVA
CLEPEEVRHRDSSFAHKPQ-ASGGQEEAPNPRSARG-HQHPT-AQAE--DPA--SAFRRA
RHQGISVLRKRYSEPVSLGLAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSANSSS-LTPLGRDALGS-LSPALED-----G--
KAARDEPGSAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----AL----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------MAK
PVRTLTTSESESMRKVMPIPKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVGSRQN
SVRRASDTSPRRTST----GT-----EEQRLLRGSSGSSSSRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPN-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDHPSA-AKAPGITRTVSQRQLRGKGD-PEDT-TPKDSGT---LRRASSARVPK
KRPESA-EGPSANTEAPLQSRGAGERA-SLRRKDSSRTALGRILNPLWK

------------------------------------MHVMNCVSLVSDKENGNSATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECLSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKTEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRAAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-ASGGQEEAPNPPSAQA-HQLAA-AQPE--DPA--SAFPRA
RRQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MELESVGHG-GPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------VAK
SVRTLTASENESMRKVMPITKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRA--------ST----GA-----EEQRLPRGSSSSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PPVPSVPHELPSVPSFARNTVAS
SSRSMRTDLPPV-AKDPGITRTVSQRQLRVKAD-PEDA-APKDGST---LRRASSARAPK
KRPESV-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCLSLANDKENGALSVAAGL
MSEDPPA-------AS--PPPPPPCPSRGTPCSAA-----------------------AP
ATPPLPGPSLPLHSQLTNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

HDGHSRKKRMRSFFWKTIPEEQVRGKT--NIWTIAARP--Q
YQIDTKTIEELFGQQEET---KPPDPRSRSLKASFKETKEEVSILDAKRSMNIGIFLKQF
KKSAESIIEDIYHGRSELYASELLNEFLKLLPEAEEVKKLKAFDGDVSKLSQADSFMYLL
IQVPNYALRIEAMVLEREFSPSCASLQDDMKIIRQATKELMTCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMSLLHFVALEAQKKDAALLNFSEKIRDVHEA
ARLSIDNVEAELHSLSFKTRSVKDSIRRDPKLFYQMENFLQFAVRHLKELEHQKQELEKE
GNALIDFFCEDKETMKLDECFQIFRDFCLRFNKAVKENREREIQELYHLQRRKELEEKRR
SWAAGELGSFGRSS----SENDVEMLAKKGLEEFL--PFLQ-QRP------QSPSYRN-P
NSKRSRLSLGITADRELQSFLEISK----EE-DPNKFNSLPRAN-------TRQVRPNVA
WTESKETRDPNLNTLHLHQQSETKG-KSSDLLQLRP-AQSNHFGS----ST-T-NAHYPQ
RSTNCNM--HA-----SNASCEESADINALALAIEEHELVKGLRKFDIQGAKPAEDMPLI
YLEDVGG----TDVETLDDL-SLHSLSTADDDL-PPACRSSREAHSHK---G---KAVGC
KSETSEPGSSSPVSMDTSVSGSREDGPMFYVSDTTTDCSLTLDSEEGNDFKSAGNEVRSE
VGK-----TRSSVNGAQYRP--RTLF-PNLNSASAKDLSL----------HASTNDKDDA
NSKHA-LSKEKS-VKNKDPV-GPKRNSLKDRSPSS--SKSSSTRPSHTA--------SSR
PVRTLNASENESMRKVVPISRSNKA--PSSVKKPEAKPALRE------TSTVESRLSRRS
SVRGTTDTVPRSPYRHSM------SVEEPRLQRGTVTSSSAHFERDR--VA----FKKPG
SKPVRSTAK--SKTDESKMCRSSVKPQTPVDDTKVS---PVSAPKTPSSVPSFARNTVAS
SSKRAKVD-LSTSSKPPGITRSVSQRLPKVKPAATSDDLNPKENV-GSTLKRANSARVFG
KSILQG-DTVSPKAETSPKEQGALDKS-SLKMKDANRTTFGKILKPLLK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PAPSPICSYSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTSHVNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITVLDAKRSMNIGIFLKQF
KRSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHNVQKT
ARLSLDNTEAELQLLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNQDREAQELRQLQRLKEQEQKQR
SWEAGELGAFGRSS----SENDVELLAKKGVEGLP--AFLH-PSPVSPSSPSSPSYRP-P
NTRRSRLSLGLSADRELLTFLESST--SIPE-EPNKFHSLPRSSP-------RQARPTIA
CLQPAEARHGDSSFAHKPQ-ASRGQEEAPNPLSTQG-HQLPA-ARPE--DPA--SAFPRA
RHHGVSILRKRNSEPVSLGSAR-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEGMSQL
TLSDFSP----MKVESVEDG-GPHSPSAGSSS-LTPMDGNALGS-LTPALED-----G--
KAAPVEPGSVALGSVGSSDPENKDPGPLLYISDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-FNPASSPPGEAPA----PV----SVGSEPS---
-CKGG-LPRDRP-TKRKDVI-APKRGSLKEASPGV--SKPGSARRSQGP--------APK
PVRTLTASESESMRKVMPISRSSRGAG---WRRPELPSR-G-PSQNPP-SSTDTVWSRRN
SVRRASDMSPRRPSS----SA-----EEQRLPRGSSSSSSTRPGRDTS-LQPRGSLKKPS
AKPLRNLPR--QKTEENKTCRTHSQGPESPKEEPKT-PPVPSIPHELPHVPSFARNTVAS
SSRSLRTDLPPV-AKVPSVTRTVSQRQLRVKGD-PEDA-TPKDSST---LRRASSARVPK
KGPEST-ESPSANTEAPLKARGAGERA-SLRQKDSSRTTLGRILNPLWK

------------------------------------------------------------
------------------------------------------------------------
----------------------------

PF02181 // ENSGT00760000118986_0_Domain_1 (149, 511)

MRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEES-AKSSPSRRGGPLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPPSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKAFSGDVAKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDMTILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAVLLNFSEKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFAVEELSELERWKQELLAE
AHTLIDFFCEDKDTVKLDECLQIFRDFCIKFNKAVKDNHDREVQELKQLQRLKEQEQKRR
SWAAGELG-FSRSS----SENDVELLTKRGAE----DPFLH-SRP------ISPSHRP-P
NTRRSRLSLGASADRELLTFLESST--GNP--EELKFNSLPRSCP-------RQAPPSRA
WMESGEQRDQDSSQAHRLP-ASKDQEEATDPPSTWQ-SQLLA-PRLE--EPA--TALPRV
RRSGVSILRKRNSEPLGLGPVR-SPPLSPLALGIKEHELVTGLAQFDLQAPKGPEEPARL
TMNDFSP----MELMSVVGE-SPQAPRAPNDR-LTPVDRSAGDA-PLPALEG-----G--
GAARDEAGSAAAGSVGSSDPESKDAG---LFSDT-TDCSLTLDCSEGTDSRPEGGCPG--
DGGDREGSVSSGAG-------DSQVS-SLPACSSPGEVPA----PRPVSVSRKSEPG---
-CQAD-PPRDRP-AREKEVM-SPKRSSVKEAPAGT--G---AARRV-AG--------AVR
PVRTLTGSENESLRKVVPIARAGRAPV--SGKRAPREAP-GGPA----------------
-------------------------------------PAAARPGRESP-APARTSFRKPS
AKPLRNVPR--PKPDEDKMCRSSSQGPESPEEAPRA-PAAPSAPRGPAPVPSFARNTVAS
SSRCLRTDSPAV-ARPPGLTRTVSQRQLRAKGG-PEEA-APKDGGA---LRRASSARGPR
KGPELP-EGPRAGSEASPKGRGAGERA-SVRLKDASRPALGKGLHPLRK

------------------------------------MHVMNCLSLVNDKENGAIPVATGL
MTEDTTTAPQLSQPAA--SLPPAPCPLTGAPPAPPLPPGMLPP---------------PP
PPPPLPGPNIPLPPQLINGHDGH

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 512)

GKKKRMRSFFWKTIPEEQVRGKN--NIWTIAARP--Q
YQIDTKTIEELFGQQEEA---KPQDSRNRTLKSSFKETKEEVSILDAKRSMNIGIFLKQF
KKSAESIIEDIYHGRSQPYGSELLHEFLKLLPEAEEVKKLKAFAGDVSKLSQADSFMYLL
IQVPNYALRIEAMVLEREFSPSCASLQDDMKIIRLATKELMTCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMSLLHFVALEAQKKDGALLNFSEKIRSVHDA
ARLSIDSIEAELHSLSVKTRSVKDSIRRDPKLFHQMENFLQFAIRYLKELEHQKGELQKE
GNALIDFFCEDKETMKLDECFQIFRDFCIRFNTAVKENREREIQELHSLQRRKELEEKRR
SWAAGELGSFGRSS----SENDVEMLAKNRLGQFL--PFLQ-QRP------QSPLYRN-T
NSRRSRLSLGMTADRELQSFLEISK----DE-DPNKFNSLPRAN-------TRQARPNVA
WTESKETRDLNLNTLHLQQQSEMEV-KSGGPVQVPP-AQPSHLSS----LASP-GAHYSQ
RGTDYSL--HT-----SNLSCEESTDINALALAIEEHELVKGLRKFDIQGAKPAEDAPLM
YLEDAGG----TDLETLDDL-SFNSLSTAHDEL-PPVCSSSREAHNHQ---A---KAVSC
KNEVLEPSSSSPMSMDTSVSGSREDGPVCYMSDTTTDCSLTLDSEEGNYFKSAGNEIN-E
GGK-----ARSSGNDVQHKA--RSFF-SNLNSTSDKNLSL----------HISASDKDDA
DNKHT-LPKEKP-IKNKDLV-GPKTNSLKDRSPSF--TKSSGTRPGHTA--------PSR
PVRTLNASENESMRKVVPISRSNRA--PSSMKKPEAKPALRE------SSTVESRLSHRS
SVRGTTDTLPRSPYRHSM------SVEEPKLRRGTVTSSSAHFDRDR--VA----LKKPS
SKPIRSNVK--SKTDETKMCRSSVKPQTPADDTKVA---TISNPKAPAAVPNFARNTVAS
SSKRAKVD-LSSSCRPPPITRSVSQRLPKVKPAATSDDPNPKENS-VSTLKRASSARVVG
RSILQG-EAVCTKAEPAPKEQGTVEKA-SLKLKDANQTTIGKILKPLLK

------------------------------------MHVMNCVSLVSDKENGTITTAAGF
MIRETAPPRPPPPPPPP-PPPPPSCPYSGEGFPPSP--PPPPPPPLPGG--------PPL
----PPPPPGLPPSSHLNGYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 511)

KKRRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDTTTKSSLSRRGGALNSSFREAREEITVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKTFSGDVSKLSLADSFLHYL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLDNTEAELHSLFIRTRSLRENIQRDGELCQQMEDFLQFAVEKLTELERWQQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCVKFNKAVQDNQDRAVQELRRLQRLKELEQKRC
SWAAGELGAFCRSS----SENDVEQLTKKGAEDLS--PFLQ-PRP------VSPSYRP-P
NTRRSRLSLGTFADRELLTFLEC-ST-DSPE-ESSKFNSLPRSS-------TRQARPTMA
WLEPGDRRAQDPRGAQTPQVSE-GERGAPEPPSSWQ-SQQLLAPRPE--DPK--PPIPRV
RRSGVGILRKRNSEPVGLGPAR-SPPLSPLALGIKEHELVTGLAQFDLQGSKSPEEVSRL
TLNDLSP----VELGSLGDG-SVQSLGASHEG-LMPVDTGVPGG-LSPALEG-------D
GTAPEDPSSKAVVSVGSSDPDSKDPGPLFYISDA-TDCSLTLDCSEPG------------
EVPGADGSLSSGAGE---TG--SQVS-SHPTSSSLGEALA----PV----SGKSQPS---
-CKDS-LPKDRP-AKGKDVT-APKRSSLKEASPGT--SKPASVRRSQG---SQ--GAAPK
PVRTLTASESESMRKVVPISRSSRGSV--GWKRPPRET---------P-SSTDAPWSRRS
SVRGTSDVSPKRSSAGAAAGAE-----EQRLARVSGGSGSARSGKDPP-LQQKGSLKKPS
AKPLRNVPR--QKPDENKTCRSNSQEE-IPEEEPKA-PPAPSVPRTPPPVPSFARNTIAS
SCRFMRAD-SSPVAKAPGITRTVSQRQLRPKGG-PEDA-GPKDSST---LRRASSARTPK
KCPESA-GAPSVNTEAPGKGRGAGERA-SLRLRNSDPTTLGKMLDPLRK

------------------------------------MHVMNCVSLVNDKENGAISVEAGL
MTGDTSEPEEQLTQPP--PPPPPPLPLPCLSTEVGLSSPATVP---------------PP
PPPPPPSLSKPSFSQLVNGHGH

PF02181 // ENSGT00760000118986_0_Domain_1 (143, 511)

SSKKKRIRSFFWKTIPEEQVRGKN--NIWTIGAKQ--N
YQIDTKTIEEFFGQPDGK---APLDSKSKALRRSFKDTKQEINILDAKRSMNIGIFLKQF
KKSFESIIGDLHSGRCDMYSCEVLRELLKLLPETEEVKKLKDFSGDISKLGQADSFMHLL
IQVPNYSLRLEAMVLKKEFSPSCSSLQKDMTIIRMATKELMCCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANRPGMNLLHFVALEAQKKDKVLLNFAEKLPHVHEA
ARISLESIEAELHSLSTKTKSLKENIRRDPELHHQMEGFLQFAVKELKELEHWKRDLLKE
AHALMDFLCEDKETMKLDECFQIFRDFCLRFSKAIKENKEREAHELQQLQRLKELEEKRQ
SWVAGDLGAFGRSS----SESDVGTLTKRGLEEFL--PFLQ-HRP------QSPSYRN-A
SIRRSRHSLGITADRELLTFLETSK----GE-DPNKSNSLPRAH-------ACQTRATVA
WIESKEPGDPNVTDLHLNQASEEHM-GCSYFP-SPP-PQSDRIDDLEVLDG-A-HANFCN
NEDGAGN--DN-----YNVPCMEAADTPPWDVSYEESEFVPGLQKFDFSEVNDMDDPSEV
N-FEVGA----GDLETMDDS-SLCHLDPATR--PVPAYRKSKEAPHKDEQAT---KGARY
ANEAPRPSINSPS-SSGNISGIKAQRPGFGVSDI-SDHSLTLDQSEENNPKLGVNKVNRN
NGA-----MAP------------------LMSNVQTDDGL----------SSFSNDKEDS
GSKPG-LPKEKS-GKGKDGF-GPKRNSLKEKSPGT--TKPATNPPN-----------HPR
PVRTLNTSENASMRKVVPISRSTKAAPPTCTKKPEPKPAPRD------TSVAETRLSRRN
SIRGITDVVPKPQYRQSI------SVEESKFQRGTAASSSGHFEREP--LQQKGSFKKPS
SKPVRYIPK--SKNDETKMCRSVPKPPSPT-EVKST---TVAAPKTPAPVPSFARNTVAS
SSKCTKVD-LPPATKAPALTRSLSQRLPRMRITAASDDANPKENG-GSTLKRANSARMIK
RNTDSS-ELLSVKAEPMLREQIIMERSASLQCKDENQTAIGKLLNHF--

------------------------------------------------------------
------------------------------------------------------------
-------PPGLPPPPLVNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGKKKRMRSFFWKTIPEEQVRGNG--IIWTLVARQQQN
YQIDTQTIEELFGQQEDT-TKSSPSRRGGTSNSSFRDAKEEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLQELLKLLP----VKKLKTFSGDVSKLSLADSFMHYL
IQVPNYTLRIDAMVLKKEFLPSCSSLFTNITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAGLLNFSEKLYHVQEA
ARLSLDNMEAELHSLFVRTRVLKENIQRDGELCQQMEDFLQFAVEKLTELDHWKQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCTKFNKAVKDNHDREVQEVRQLQRLRELEQKRR
SWVAGELGGFGRIS----SENDVELLTKKGTEDLL--PFLH-LRP------MSPSYRP-P
NTRRSRLSLGIATDRELLTFLSSTD----P--EESKKFSLPRSRP-------LAARPTIA
WMEHGEQRDLNS-LAHGLQ-DLGNQEEAPNPSSASS-HHPRA-PQPG--DHG--SAVPQV
PRGRVGILRKRNSEPVGLVPAQ-SPPFSPLALGIKEHELVTGLAQFDLQGPKSPEETCPQ
PLNDLNR----VERASLEGG-SLQPHSTGDDG-LRPVGGGAQGG-LVPGTEA-------G
GAAPDEPGSAALVPVGSGDLENQDPSPLFYISDT-TDSSLTLDCSGRTDSRPSGEEPE--
EAAKGDRSVSSGAGEA---G-DSQAS-SNPAPSLPGEAPA----SV----SERSRPS---
-SKGG-FPRRT--VKGKDVT-APKR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MHVMNCVSLSSDKENGTLATAVGF
MTGQTSPPASPPPPP-P-PPPLPPCPHSGEGFSPSPPPALPPP--LPGG--------PPV
---PP-PPPGLPPVSQMNGCSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAK-QHH
YQIDTKTIEELFGQQEDT-TKASLPRRGGALNSSFREVREEITILDAKRNMNIGIFLKQF
KKSPRSVVEDIHQGRSEHYGAETLREILKLLPESEEVKKLKTFSGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTAAKELMACEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEKLHHVQET
ARLSLDNTEAELHSLFVRTKSLQENIQRDQELCQQMEDFLQFAVEKLAELKLWKQELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREVHELRQLQRLKELEEKRR
SWAAGELGGFGRSS----SENDVELLAKKGTEDLP--SFLH-PRP------TSPSYRP-P
NTRRSRLSLGISADRELLTFLESTT--SSPE-DTNKFNSLPRSSP-------RQPRPTIA
WMEPGEQRDHDHNFAHEPQASKNGE---KAPHPAWQ-SQLPK-PTLE--EPA--SILPRT
GRGAMSILRKRNSEPVGLGPMP-NVPLSPLTLGIREHELVTGLAQFDLQSPKGMEEASQQ
TLNDFCP----TELQSPGDK-GPLSFGTGSDS-LTPVSTSPQEG-LSPAGEG-----D--
GAAPDDPSSRALLSLGVTDIENKDAGPLFYVSDT-TDCSLTLDCSEGTDSRPGREERE--
IEREGDESMSSGTGEA---G-GSQVS-SNPASSPPGEMPA----PP----LGKSEFS---
-CQGG-LPRDRA-SRGKDAV-APKRNSLKEASLGA--SKPISVRRSHGA--------APK
PVRTLTSSENQHMRKVVPISKSSRGAG--GWKRPEPPSR-GF-PRETP-GSTDTPLSRRS
SVRGTLDTSPKRPHVGGP-VT-----EEPRLPRGS-GSVSGRSGKEPP-LQLRPSLRKPS
AKPLRNIPK--QKPEENKVCPSTSQDSESPEEEPKA-LRAPSTPRVPLPIPSFARNTVAS
SSRCMRTDALPV-ARTPGITRTVSQKHLRVKGS-PEDA-TSKDSGT---LKRASSARAPK
KCPDSA-EGSIANMEAPLKGRGATERA-SFKLKDSGQGTLGRILHPLRK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-SPPSPTCSYSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTSHVNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDI-TKSSLPRRGRTLNSSFREAREEITVLDAKRSMNIGIFLKQF
KRSPRSIVEDIHQGKSEHYGLETLREFLKFLPESEEVKKLKAFSGDASKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLKTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHNVQKT
ARLSLDNTEAELHLLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNQDREAQELRQLQRLKEQEQKQR
SWASGELGAFGRSS----SENDVELLAKKGVEGLP--PFLH-PRPISP---SSPSYRP-P
NTRRSRHSLGLSADRELLTFLESST--GIPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPKEARHGDSSFAHKPQ-ASRGQEEAPNPPSAQG-HQLPA-TQPE--DPASASAFARA
RRHGVSILRKRNSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEGMSQV
TLSDFSP----MKLESVEDG-GPHSPSAGSSS-LTPMDGNALGS-LSPVLEN-----G--
KAAPVEPGSVALGSVGSSDPENKDPGPLFYISDT-TDCSLTLDCSEGTDSRPRAGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS--NPASSPPGEAPA----PI----SVDSEPS---
-CKGG-LPRDRP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGL--------APK
PVRTLTASESESMRKVMPISRSSRGAS---WRRPELPSR-G-PSQNPP-SSTDTVWSRRN
SVRRAS--------T----SV-----EEQRLPRGSS---SARPGRDTP-LQPRGSIKKPS
AKPLRNLPR--QKPEENKTCRTHSQGPESPKEEPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSLKTDLPPM-AKVPSITRTVSQRQLRVKGD-PEDA-DPKDSST---LKRASSARVPK
RGPEST-ESPSANAEAPLKARGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPPPCPHSGEGFPPSPPPPLPPP--LPGG--------PPI
---PPPPPPGLPSVSYLNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQYQ
YQIDKKTIEELFGQQEDT-SKASLPKRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSSLFQDIRTLRAATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEKLQHVQET
SRLSLDITEAELHSLFVRTKSLQENIQRDQELCQQMEDFLQFAVEKLAELELWKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRY
SWTTGELGSFGRSS----SENDVQMLAKTGTEDLP--SFLK-PRP------NSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPTIA
WMEPREQQSHGPNFTHEPQASKIQEK--VSPPPAWQ-NRLPT-TWPE--EPA--SPFPPA
GRGRPS-LRKRNSEPVGLGPTQ-SPPLLPLDLGVREHELVTGLTQFDLQSPKSLEEASQL
TLNDFCP----TKLPSSGDR-SSQPFAAGGDS-LPPKDTDTQEV-LSPAGED-----D--
RTISDEPSSEALVSVVVTDTEDKDAGSPLYVSDT-TDCSLTLDCSEGMDSRAGGDKQE--
EEKEGDGSVSSGAGEA---G-SSQVS-SNPASSPPGEVAA----PK----SSKSELS---
-CQGV-LPKDRP-SRGKDAI-APKRNSFKEASVGA--SKPVSARRSQGV--------ATK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTPK-A-TPRETP-SSTDTPLSRRS
SVRGTSDTSPRRPQVSGS-GA-----EEPRLPRSS-GSISGRPGKDAP-LQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSPDPESPKEEPKA-PQATGVSRALPPIPSFARNTVAS
SSRSLRTDAPPA-ARTTGLTRTVSQRQLRVKSG-SEDS-ASKDIGT---LKRASSARASK
KCPESA-GGSSANVETPLKGRGTTERS-SLRLKDSGQATLGRILRPLQK

------------------------------------MHVMNCVSLVSDKENGAPASAAGF
MISQTPPPPPPPPPL---------CPS-----------PAPPPPPLPG---------PP-
---APPPPPGLPPTSHM

PF02181 // ENSGT00760000118986_0_Domain_0 (138, 1309)

NG--HLGKKKRLRSFFWKTIPEEQVRGKN--NIWTLAARKQQH
YQIDTKTIEELFGQQDGT-PKVSPSRRGAASHSSFREAREEXXXXXXXXXXXXXXXXXXX
XXSPQSIVEDIHEGKSEHYGAETLREILKLLPESEEIKKLKSFSDDVSKLSLADSFLHYL
IQVPNYLLRIEAMVLKKEFLPSCSALYTDITILRTATKXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXLSLENTEAELHSLSVRTRALRENIQHDGELCQQMEDFLQXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDNHNRQVQERRQQQRLQELEQKRR
SWATGELGGFGRSS----SENDVELLSKRGAEDLP--SFLN-PRP------PPRE--P-P
GT------------------------------------------------------TEPA
WVRRSSVR----------------------------------------------------
------------------------------------------------------------
---------------RPS------------------------------------------
------------------------------------------------------------
------------------TG----------------------------------------
----G---------------------------------------------------T---
------------------------------------------------------------
-------------------------AEEPRLQR-ASGSVSSRPGKDVR-LQPRSSVRKPS
AKPLRNLPRANQKPDENKICRSNSQ--EGPEEEPKPPPAPPSVPRVPAPVPSFARNTVAS
SSRCMKTD-AAPVARAPGLTRTVS-RQLRMKGG-LEDT-FSKDSGA---LRRASSARSPK
KCAESAVEGPGSTPEAVPKGRGTGERG-SLRLRDASPTALGKILNPLRK

------------------------------------MHVMNCVSLASDKENGNIATAAGF
MIGQTSPPSPPSPPPPP-PPPPLPCPCSGGDGPPSAPPPPPPP-----L--------PWG
---PP-PSAGQPLAPQENSFGSLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 511)

KKKRMRSFYWNTIPEEQVRGKT--NIWTLAGREQHH
FQIDTKSIEELFGQQEDI-AKASVPKRGGTLNSSFRDAREEITILDAKRNMNIGIFLKQF
KKSPRSIVEDIHQGKSENYGLETLGEFLKILPESEEVKKLKTFSGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITSLRSAIKELISCEELHAILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLSHVQEA
ARLSLDNTEAELKSLVVRTRSLKENIKPDVELCQQMEDFLQFATEKLADLEQWKQKLQRE
AHTLIDFFCEDKGTMKLDECLQIFRDFCTKFNKAVKDNREREAQESRQLQRLKATEERRH
HWAAAELGAFGRSS----SENDVELLTNKGAE-DQ-APFLRPGTE------SSSSR-P-P
NTLRSRHSLGISAERELLTFLERAT--TGCP-EEPKFNSLPRSRA------RQ-ARPAVA
RMQPGEAGDRHLPSVHRPQASPAGPERVPEPPCPWR-GQPPP-G-PE--EQA--SAVPRA
RRGGLGALQKRNSEPAGLGPAG-TPALPSLALGVQEHELVAGLAQFSLEDPKGRQQPARL
AQRDAGP----GAS--PGPG-TPPAPSAGSDR-VTPVSSGPQEG-PGPAPEA-----D--
---TAEPGGKASGSVGSGAPEDGDPGPC-HVSDT-TDCSLSLDCSEGVEPRPGGARPG--
EDTG-----------------ALQAS-PLPASSPAGEAPA----PD----SVKSEPA---
-CKAG-LARDRL-AKGKEAS-VPKRSSLREAPPGT--AKPGSARRSAGT--------ATK
PVRTLTASESQSMRKVVPISKAGRAPS--AGTEDQRPTR-G-------------------
-------------------------------------SGGARPGKEAA-LQPKGSLRKPS
AKPLRNVPR--PKPEDSKLSFSPAQRPEEK---PKT-----SPARGPPSTPGFARSTFAS
SSRCVRTDATPA-ARTPGLTRTVSQRQLGPKGG-PEDA-APKDSGP---LRRASSARVPK
KGAEST-EGPGAVSGRAAPRRQS---S-GRT-------ALGRILHPLGK

------------------------------------MHVMNCVSLASEKENGDLSAAAGL
MIGQTAPPPLTTPPP-----PSRSCPDNGCPSSPXXXXXXXXX--XXXX--------XXX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX

PF02181 // ENSGT00760000118986_0_Domain_1 (208, 512)

XXXXXXXXXXXXXXISVLDAKRCMNIGIFLKQF
KKSPQSIVEDILQGNCEHYGSETLREFLKLLPESEEXXXXXXXXXXXXXXXXXXSFVYFL
IQVPNYSLRIEAMVLKKEFLPSCSSLWDDMSILRVATKELMSCEELHSVLHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVALXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXELQKE
AHALIDFFCEDKETMKLDECLQIFRDFCTKFDKAVKXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-XXX------XXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXX------XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXX--XXX--XXXX-X
XXXXXXXXXXXXXXXXXXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX----XX-XXXXXX-XXX-XXXXXXX-XXX------XX-XXXXXXXXXXXXENG
NSALKEPRSVVSPSADTSESENKEAGVIVYISDT-TDCSLTLDCSEGNDPQMGSSKSK--
EEKTVNGSISSGTGDMEGET--RSVP-SMPNFSPTREDCA----FA----VGRNELG---
-YKCG-LPKDKV-VKGKEAA-GPKRNSLKDTPTGT--SKPGSVRRSLGP--------SSK
PVRTLNASENESMRKVVPISKSSRGSG--SWKRLEVPAR--TSPREAS-SSTDTRLSRRS
SVPKA-----------------FVAAEEQRLHRGNITSSSTRLGKDSP-LQHKTSLKKPS
AKPIRNLPK--AKADETKICRTNPQETEDVEEVPKP-PPPVTIPRPPPPIPSFARNTVAS
SSRRLKTDSS-PISKVPSITRAASQRQLRIKTT-SDDT-QTKNGGI---LRRTSSARTAP
KCPEPS-GSTSIKEEAPLKGRGMVEKS-SLKRNDSNRTTLGKILNPLWK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLCGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPRSVGHE-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGGAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNLTSSPPGEAPA----PL----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRTST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSGT---LRRASSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLCGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSAQG-HQHPA-AQPE--DPA--SAFRRA
RHQGISVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPRSVGHE-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGGAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNLTSSPPGEAPA----PL----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTMWSRQN
SVR---------TST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSGT---LRRASSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLVSDKGNGNTATAAGF
MTAQAPPPPPP-------PPPP----LPPQGLPPSPPPPPP----LPRG--------PPG
---PP-PPPGLPPNSHLNGYSQLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFYWKTIPEEQVRGKT--NIWTLAASQQHR
YQIDTKTVEELFGQQEDA-TMAPPSRRGGSLHSSSREAREEITLLDAKRSMNIGIFLKQF
KKSPPSIVEDIHQGKSEHYGSETLREFLKLLPESEEIKKLKAFSGDVGKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDMTILRNATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDVVLLNFSEKLLHVQEA
ARLSLDNTEAELHSLFVRTKSLKENIQRDRELCQQMEDFLQFALEKLAELERWKRELQDE
AHTLIDFFCEDKDTVKLDECLQIFRDFCIRFNKAVKLNFSEGLLSVSA--ALSSLERRPR
DLGEAEAA-GGAQSPRWPSVSRSCPRSLRGMEASS-PPGTC-MCQ------H---RPS-P
SXRGPRLSLDTMADRELLSFLERST--GSPE-EL-KPSNSSRGCL-------WQVPPDGA
CREPGEPRGQDSSLAHRPR-ALEGQEEAPHPATAWA-SWLPA-AHLE--DPA--CTLRHP
RRSGVSTLRKRNSAPVGLDPVRSSAPLSPLALGIREHELVTGLAQFDLQAPARR-SLAQL
TGNDCSP----MELVSVGDA-SPQSLGAPKSSPTTPVGRGARVA-PSP----------DG
EAAPYEPRSAAPLSEGSSDPGSQDPGPLFCISDT-SDCSLTLDCSE--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------M

PF02181 // ENSGT00760000118986_0_Domain_1 (232, 512)

NIGIFLKQF
KKPAESIIEDISKGKGDFYGSEMLREFLKLLPEAEEVKKLKAFDGDVAKLCQADYFMYLL
IKVPNYSLRIEAMMLTREFVPSCTSLQKDMKIIRSAMKELMSCEELHSILYLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVALEAQKKDEALLTFSEKLQHIHDA
ARLSIDNIEAELHSLSAKTRSLKNNIRQDPGLFHQMEDFIKLAIKELKELEYWKRELRGQ
GNTLIDFFCEDKETMKLEECFQIFRDFCMKFNKAVKENRERESQELQQQQKLKELEEKRR
SWAAGELGGFGRSS----SENDVEMLAKKGLEDFR--PFLR-QRP------QSALNRN-P
SARRSRLSLGITADRELLSFLEISK----DE-DPNKFNSLPRAN-------TRQARPSIA
SIESKEPSNLSLNNLKLHRASEAKA-DSPDPPQMPL-AQPSRLQDMEVGLTST-NLCYSQ
KNTDNKQ--HR-----SAVPCVEAGDINAGPLAVEEYEVVKGLHKSDIQGTKPMEDMPLI
SFADVGA----TDLETLDDL-SLHSLSTVDNSEPMPSCKSSRNIDDCQ---V---KVASA
KHEVSEHTNSGPTSMDTSVSGNKEHGPTFYVSDA-TDCSLTLDYSEGNDLKLVGNEMKEQ
DVK-----VYTCANDVRDED--STVS-SNLNSSSEKEISL----------HTSSNATEDS
SSKHN-FPKEKP-VKSKESL-GPKRNSLKDRSLNS--SKSSGTRPTQTT--------TPR
PIRTLNASENVSMRKVVPISRSNKT--QSSLKKPEAKPALRE------ASTTETQPSHRS
SVRGTMETLPRTSYRHSL------SVEEPKLQRGTATSSSTHFERDQ--LQRKGSLKMPG
SKSVRNIPK--SKPEESKICRSIVKPQALPDANKST---TANAPKTPSSVPSFARNTVAS
SSRSAKVD-LPNSSKTPSITRSVSQRLPRMRSAATSDDLIPKEST-GYSLKRASSAKIIK
RNTDQS-DILSAKVEPTAKEQDIMEKS-SHKLKDENRTTIGKIFKPLLK

------------------------------------MHVMNCVSLVSDKENGTVTTAAGF
MIGQTPPPAAPPPPP---PPPPPPCPYLGEGFPPSP--PPPLPPPLPGG--------APV
----PPPPPGPPPVSHMNGYSQLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 511)

QKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDTKTIEELFGQQEDP-TKSSLSRRGGSLNSSFRDTREEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLRDFLKLLPESEEVKKLKTFSGDVSKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLAELEHWKRELQHE
AHTLIDFFCEDKETMKLDECFQIFRDFCTKFNKAVKDNYDREVQELRKLQRMKELEQKRR
SWAAGELGGFGRSS----SENDVLLLTKKGAEDLP--AFLH-PRP------SSPSYRP-P
NTRRSRLSLGISADRELLTFLES-ST-GSPE-EPSKFNSLPRSS-------PWQAPPAVA
WMESAEPRDLNSDFAHEPQASE-SQEKAPEPPSAWR-NALAAAGREE--LAA--VAFPRA
RRGGNSVLRKRNSEPVGLGPAR-SPPLSPLALGIKEHELVTGLAQFNLQGPKILEETSRP
ALNDSSP----AELGSPGDG-CPRPLSAGTGS-LTPGDSGAQGA-LSLDPGA-------D
RAAPAEPSDTALVSAGSSDPESKGPGPLFYISDV-TDCSLTLDCSEGTDSRPAAGEPE--
EAGEGDGSVSSGVGDA--TGG-SQVS-SNPASSPAAEAPA----PA----SVKSEPS---
-CKGG-LPRDRL-AKGKDVT-APKRNSLKEAPPGL--PKPGV-RQG----------AAAR
PVRTLTASESESMRKVVPISRASRGAG--AGKRPEPS----RAPESPP-GSTDAPWSRRS
SVRSTADTSPRRPA---------------------GAGSSARPGKEPP-LQRRGSLKKPS
AKPLRNVPR--QKPEENKICRSHPQGPESPEEEPKT-PPAPSVPKVPPPVPSFARNTVAS
SSRCTRTD-APPAARAPGLTRTASQRQLRVKHG-PEDA-ALKDSGT---LKRASSARAPR
KCPEPA-AGPGAHAEVPVKGRGAGERA-PLRPKDSHRTALGKILSPLGK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGPPPATHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKEELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPRSVGHE-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGSAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNLTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRTST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSGT---LRRTSSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SVRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PAPSPTCSYSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTSHVNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKPSLPRRGRTLNSSFREAREEITVLDAKRSMNIGIFLKQF
KRSPRSVVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSRLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPTCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLDFSEKLHNVQKT
ARLSLDNTEAELHLLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTKFNNAVKDNHDREAQELRQLQRLKEQEQKQR
SWAAGELGAFGRSS----SENDVELLAEKGVEGLP--PFLH-PSPISP---SSPSYRP-P
NTRRSRLSLGLSADRELLTFLESST--GIPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEARHGDSSFAHKPQ-ALRGQEGAPNPPSAQE-HQLPA-ARPE--DPA--SAFPRA
RRHGVSILRKRNSEPVSLGSAR-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEGMSQL
TLSDFSP----MKLESVEDG-VPHSPSAGSSS-LTPMDGNALGS-LSPALED-----G--
KAAPVEPGSVALGSVGSSDPENKDPGPLFYMSDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEL---G-DSQVS-SNPASSPPREAPA----PV----SVDSEPS---
-CKGD-LPRDRP-TKRKDVI-APKRGSLKEASPGA--SKPGSARRSQGP--------VPK
PVRTLTASESESMRKVMPISRSSRGAG---WKRPELPSR-G-PSQNPP-SSTDTVWSRRN
SVRRAS--------T----SA-----EEQRLPRGSSSSSSTRPGRDTP-LQPRGSLRKPS
AKPLRNLAR--QKPEENKTCHTHSQGPESPKEEPKT-PLVPSIPHELPRVPSFARNTVAS
SSRSLRTDLPPM-SKVPSITRTVSQRQLRVKGD-PEDA-APKDSST---LKRASSARVSK
KGPEST-ESPSANTEALLKARGAGERA-SLRQKDSSRTTLGRILNPLRK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPPPCPHSGEGFFPSPPPPLPPP--LPGG--------PLI
---PP-PPPGLPPVAQVNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQQH
YQIDKKTIEELFGQQEDT-SKASLPRRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSEMLREILKLLPESEEVKKLKTFNGDASKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPSCSSLFKDMTILRTATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAKLLHFSEKLQHVQET
SRLSLDVTEAELYSLSVRTKSLQENIQWDQELFQQMEDFLQFAVEKLSELELLKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRLKELEQKRY
SWTTGELGGFGRSS----SENDVQMLANKGTEDLP--SFLK-PRP------TSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPIIA
WMEPREQKNHDPNFAHEPQASQNQEK---APSFAWQ-SQLPT-PQRA--EPA--SPFPLA
RRGRVSILRKRNSEPVGLGPTQ-SPPLLPLDLGIREHELVTGLAQFDLQSPNCLEEASQL
TLNDFCP----TKLQSPGDQ-SSQSFDTVSDS-LTPKDTVPQEV-LSPAGEN-----N--
EAGSDEHSSEALVSVVVTDTEDKDPGPVLYVSDT-TDCSLTLDYSEGTDSRPGGEEQE--
EEREGGGSVSSGAGET---G-SSQ-I-SNPASSPPGELSA----PN----SSKSEPS---
-CQGG-LPKDRS-SKGKDAI-APKRNSLKEASPGA--SKPASVRRSQGA--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPELTSR-A-SPRETP-SSTDTLLSRRS
SVRGTSDTSPKRPHVTGP-GA-----EEPRLPRSS-GSISGRPGKEAP-VQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSEDPESSKEEPKV-PQTPGVSRALPPVPSFARNTVAS
SSRCMRTDAPPA-SRAPGITRTVSQRQLRVKGG-PEDS-ASKDSGT---LKRASSARASK
KCPESS-GGTSANAETPLKGRGTSERA-SLKLKDSGRATIGRILHPLQK

------------------------------------MHVMNCVSLVSDKENGTIATAAGF
MIEETPPPPPP---PPP-PPPPPPCPYSEEGFAPSL--PPPPPHALPGG--------PPV
----PPPPPELPPASHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQHQ
YQIDTKTIEELFGQQEDA-TKPSLSRRGGSLNSSFKEAREEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGAETLREFLKLLPESEEIKKLKTFHGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDIRILRMAIQELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKNDAILLNFSEKLHHVQEA
ARLSLDNTEAELHSLSVRTRSLKENIRRDDELRQQMEEFLQFAVEKLTELEHWKRELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCTKFSKAVKDNHNREVQELRQLRRLQELEQKRH
SWATGELVGFGRSS----SENDVEQLGKKSAEDLP--PFLH-RRP------ISPSCRR-P
NTRRSRLSLGASADRELLTFLEN-SV-GSPE-EANKFNSLPRSS-------PRQARSASA
WRESGEPRDQGSGRTHRPQASA-GQEGAPDPPSASC-GQ-LLTPQME--DSA--PVLLRT
RRSGLSMLQKRNSEPVGLASPW-SPPLSPLALGIKEHELVTGLAQFDVQGPKDPEETPQR
SPTNFSP----VELASPGDG-SLQPLGAGTGN-GSLTRLHAQES-LSAGLQG-------D
GAAPDEP---------SINPENKDPGPLFYFSDT-TDCSLTLDCSEETDTRPGGGEPG--
EAGQGDGSVSSGAGE---AGG-SQVS-SNPLSSPPGEAPA----PA----SAKTGPS---
-CRGG-LSRERS-SKGKEAT-TPKRNSLKEASQGA--PKPGAVPRGQ--------GTAPK
PVRTLTSSESESMRKVVPISRASRGSS--GWKQPPR---------EPP-SGTQESWSRRN
SVKGTSDTSPKRSSKGPGVVAEVTEEQEQKPPRGRVGSCGTRPGKEPA-LQPRGSLKKPS
AKPLRNVPR--QKPEENKICRSNSQDPQSPGEEPKPPPPTPSVPRVPSQVPGFARNTVAS
SSRFMKTD-SLPVTKAPGLTRTVSHRQLRMKGG-SEDA-VPKDSGT---LRRAYSSRAPK
KCPESA-EGPGANMEASLKGRGTGERT-SFRQKDSGRTTLGKILHPLWK

------------------------------------------------------------
------------------------------------------------------------
----------------------------

PF02181 // ENSGT00760000118986_0_Domain_2 (149, 276)

MRSFYWNTIPEEQVRGKT--NIWTLAAREQHH
FQIDTKSIEELFGQREDT-AKSSVPKRGGTLNSSFREAREEITILDAKRNMNIGIFLKQF
KKSPRSIVEDIHQGKSENYGLETLREFLKVLPESEE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------SPI
---PP-PPPGLPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDRKEQELRQLQRLKEQEKKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-ASGGQEEAPNPPSARG-HQLPA-AQPE--DPA--SAFPRA
RRHGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQSVE-TSQL
TLSDFSP----MELESVGHG-GPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPESKDPRPL--------------------DSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPTGEAPA----PV----SVDSEPS---
-CKGG-PPRDKP-TKRKDVV-APKRGSLKEASPGT--SKPGSARRSQGA--------VAK
PVRTLTASENESMRKAMPIAKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRP---------ST----GA-----EEQRLLRGSSGSGSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PPVPSVPHELPRVPNFARNTVAS
SSRSMRTDLPPV-AKAPGITRTVSQRQLRVKGD-PEDA-APKDSGT---LRRASSARAPK
KCPESA-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGGILNPLWK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPVPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRPSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----S--
TAAPDEPGSAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRTST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRASFKKPS
AKPLRNLPR--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSGT---LRRASSARAPK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRRDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLASDKENGNIAPAAGF
MIGQESPPASPPPPPP--PPPPPPCLYSGEGLSPSP--PPPPPPPLPGG--------PPG
----PPPPPGPPPTSHMNGYSSLGK

PF02181 // ENSGT00760000118986_0_Domain_1 (146, 511)

-KRMRSFFWKTIPEEQVRGKT--NIWTLAARQQHH
YQIDARTIEELFGQQEDT-TKSCLPRRGGPLNSSFRDAREEITILDAKRNMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPELEEVKKLKTFSGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGRYAGNAVGFKLSSLLKLADTKSNKPGMNLLHFVAQEAQKKDANLLNFSGKLHHVQET
ARLSLDNTEAELHSLFVRTRSLKENVQRDAELRQQMEDFLQFALEKLTELEYWKQELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNQDREVQELRQLQRLKEQEQKRR
SWASGEL-GFARSS----SENDVELLTKKGAEDLS--PFLH-PRP------ISPSYRP-P
NTRRSRLSLGTSADRELLTFLES-GA-GSPE-ALHKFNSLPRRG-------PRQARPLVA
WMEPGEPRAGGPSGAQEPRAPE-GQEKATELPSAGQ-SQ-PPAPQPE--EPA--SASPRA
ARAGAGLLRKRNSEPVGLGPAW-APPLPPLALGIKEHELVTGLAQFSLQGPKVLEETSPL
TLSDFSP----VELASLGDG-NPPSLGAGRDR-LTPVGRGPQEG-PRPAPED-------D
RAAPEEPSGAAVASVGSSEPESKDPGPPWCVSDT-TDCSLTLDCSEGADSRHGQGEPE--
-E-----------ER---EGD-GSVS-SNPASSTPGEAPS----PL----SMKSEPG---
-PKGD-LPRDRP-SKGKDAA-GPKRNSLKEASPGA--SKPGAARRSP--------GAAPK
PVRTLTASESESMRKVVPIARASRAPG--GWKRPEQPS--RWD----A-PGSTDTLSRRS
SVKGTSDTSPRRASTGAGATVA----EEQRL-S-RGS--STRLGKEPP-LQPRGSLKKPS
AKPLRNLPR--QKPEENKVP-------ESPEEEPKA-PPAPSAPRVPPPVPSFARNTVAS
SSRCQRTD-PP--AGAKGITRTVSQRQLRVKGS-PEDA-ASKDSSS---LRRASSARVPK
RGPESA-ESPAADAEAPVKGRGLGERA-SLRLKDSGRTALGRVLNPLHK

MVDWNLEEYDGRGSSIIGCSKCSSSQENTSLEGCSTMHVMNCVSLASEKENGEVSVAAGL
MIGQTPPPPPPPPPPP--PPLPLPCPDNGCP-------PVPPPPPLPGG--------PPA
PPPPPPPPPGLPPSSYVNGHGHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 512)

SKKKKMRNFFWKTIPEEQVRGKT--NIWTIAERQSQK
YQIDTKTIEELFGQQEDT--KSFVSRRGGTLNASFKEAKEEVSVLDAKRCMNIGIFLKQF
KKSPQSIVEDIHQGNGEHYGSETLREFLKLLPESEEVKKLKTFSGDAAKLSLADSFIYLL
IQVPNYSLRIEAMVLKKEFLPSCSSLWDDMSTLRMATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVALEAQKKDAVLLNFSEKLRHVQVA
ARLSLDNTESELHSLSTRTKSLKENIQRDPELCQQMKAFIKFALQKLEELERWREELQKE
AHALIDFFCEDKETMKLDECLQIFRDFCTKFDKAVKDNRDREIQEFRQLQKLKGLEEKRR
SWAAGELGGFGRSS----SENDVELLTKKGLEDFL--PFLH-QRP------VSPSHRP-P
NARRSRLSLGTSADRELLTFLETS----TGE-DLNKFNSLPRTS-------TRQARPSVA
WMEPTEPKDVNSNHLHFYPAPE-TEKVCNNPPPSQP-GQ-FLNPCLE--NSN--AILYCT
QSHANNSNLQRDSGPGAQPLAS-FPPLSTLTMGIEARELAHGLIQFDLQEPASQEEPPRF
TSEDSSP----GESESLDDA-SLPSLTAGDDI-PVPIGKDSKKV-TGRENGA--MVPKDM
VADVTVSSSTVPASPDKSESESKEAGPIFYISDT-TDCSLTLDCSEGNDPQVGSHESK--
MGKPVNGSVTSDPGDTEGETSSSRVP-SIPNFSPTREDST----LA----LGKNEPG---
-DKCG-LPREKV-VKGKEAA-GPKRNSLKDTPMSA--PKPGSMRRSL--------GPPSK
PVRTLNASENESMRKVVPISKSSRGSG--SWKRPEVP-A-RVTPREAP-SNTESRMSRRS
SVRGTADTSPRRPSGVAVAAA--VAAEEQRLQRGNAMSSSIRLGKDYP-LQHKTSLKKPS
AKPIRNLPK--PKADETKICRTNPQESEDAEEAPKPP-PPV--PRVPPPIPSFARNTVAS
SSRRLKTD-LPPVSKVPGITRAASQRQLRMKTA-PEDT-QTKNGSS---LKRSSSARTAQ
KCPEPS-ESTSGKGETSLKGRGTGEKS-SLKRKDSNRTTLGKILNPLWK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPP--P-PPPPPPCPHSGEGFPPSPPPPLPPP--LPGG--------PPI
---PPPPPPGLPSVSYLNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQHQ
YQIDKKTIEELFGQQEDT-SKASLPKRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQF
KKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFSEKLQHVQET
SRLSLDITEAELHSLFVRTKSLQENIQLDQELCQQMEDFLQFAMEKLAELELWKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRY
SWSTGELGSFGRSS----SENDVQMLAKTGTEDLP--SFLK-PRP------NSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPTIA
WMEPREQQSHCPNFTQEPQASKIQEK---APPPAWQ-NQLPT-TWPE--EPA--SPLPLA
GRSRPS-LRKRNSEPVGLGPTQ-SPPLLPLDLGVREHELVTGLTQFDLQSPKSLEEGSQR
TLNDFCP----TKLPSPGDR-SSQPFTAGGDS-LPPKDTNTQEV-FSPAGED-----D--
RTISDEPSSEALVSVVVTDTEDKDAGSLLYVSDT-TDCSLTLDCSEGMDSRAGGGKQE--
EEKEGDGLVSSGAGEA---G-SSQVS-SNSVSSPPGEVPA----PK----SSKSELS---
-CQGG-LPKDRP-SRGKDAI-APKRNSFKEASVGA--SRPVSARRSQGV--------TTK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTPK-A-TPRETP-SSTDTPLSRRS
SVRGTSDTSPRRPQVSGS-GA-----EEPRLPRSS-GSISGRPGKDAP-LQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSPDPESPKEEPKA-PQATGVSRALPPIPSFARNTVAS
SSRSLRTDAPPA-ARTTGLTRTVSQRQLRVKGG-SEDS-ASKDIGT---LKRASSARASK
KCPESA-GGSSANVETSLKGRGTTERS-SLRLKDSGQATLGRILRPLQK

------------------------------------MHVMNCVSLASDKENGNPATAAGF
MIEQTPPP---------------PCPFSGQGFLPSPPPPPPPP--LPGG--------PPA
---PP-PPPGLPPAPHINGYSQ

PF02181 // ENSGT00760000118986_0_Domain_1 (143, 511)

VGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAASQQHH
YQIDTKTIEELFGQQEDT-AKPTLPRRGGTVTSSFREAREEITLLDAKRSMNIGIFLKQF
KKSPRSIVQDIHQGKSEHYGSETLREFLKLLPESEEVKKLKAFSGDVSKLSLADSFLYHL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDATILKAAMKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKSNKPGMSLLHFVAQEAQKKDAVLLQFSAKLQHVQEA
ARLSLDSTEAELRSLFVRTRSLQENMQRDAELGQQMEDFLQFAVEKLTELEHWKQELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCVKFNKAVQDNHDREVQELRKQQRLKDLEQKRR
SWTAGDLGGFGRSS----SENDVELLTQKGSEDLP--PFLH-PRP------SSPSYRP-P
SSRRSRHSLGLSADRELLTFLESSS--GSSE-ESNKFNSLPRSSP-------RQARPTLA
WTEPGAPRRHDSNIAPRAE-ASESQERAPNPCSDGQ-SQPPAPPGHQ--EPA--SAFPRA
RRSGASVLRKRNSEPVCLDPAW-TPPLSPLALGIKEHELVTGLAQFSLQGHKGLEEPSRL
TPSDSSP----EGQESPGDR-SPPQPLSSEGR-RSP------RA-PSPAVE-------NG
GAAPEEPSGAALVSAGSSDPENKDPVPMLYISDA-TDCSLTLDCSEGTDSRPSVAQLE--
EAGDEGASESSGAGTT---P-GSQVSSSNPASSPAGEAPA----VA-----VKSEPS---
-ANGG-LPRVRS-AKGKEVA-TPKRNPPREAAPST--CRPASVRRGQGA--------APK
PVRTLNASESESMRKVVPISKASRGPA--GWKRPEPPPS-RASPRDSP-GSVDARLSRRG
SALGTSDTSPRRPSTGAEAVV-----AVEE---PRPPRSSTRPWREAP-VPSRGSLKKPT
AKPLRNLPR--QKPEENKVCRSSSTSEGA---------------DDEPRVPSFARNTVAS
SSRCMRTDPPAA-SRAPGLTRAVSQRQLRVKGT-PEEE-ASKDSGT---LRRAGSARSPR
KGADCA-EAPGASRETLPKGRALGERA-SFRLRDASRTTLGKILDPLWK

------------------------------------MHVTNCVSLVSDKENGTIATAAGF
MIGETPPPAAPPPPPP--PPPPLPCPYLGEGFPPSP--PPPLPPPLPGG--------PPV
----PPPPPGPPPISHMNGYSHLGK-----------------------------------
-----------------------------------------------

PF02181 // ENSGT00760000118986_0_Domain_1 (228, 511)

-KSMNIGIFLKQF
KKSPQSIVEDIHQGNSEHYGSETLREFLKLLPESEEVKKLKTFSGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDIMILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLDNMEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFATEKLTELDRWKRELQDE
AHTLIDFFCEDKETMKLDECFQIFRDFCTKFNKAVKDNHDREVQELRQLQRMKELEQKRR
SWAAGELGGFGRSS----SENDVLLLTKKGAEDLP--AFLH-PRP------ISPSYRP-P
NTRRSRLSLGVSADRELLTFLES-ST-RSPE-EPSKCNSLPRSS-------PRQARPTVA
WMESAEPKDHNSNFAHKPQASE-SQEKAPQTPSAWR-KPLAAAGREE--A-A--EAFPRA
RRGGNSVLRKRNSEPVGLGPTR-SPPLSPLALGIKEHELVTGLAQFNLQGPKILEETSRP
TLNDSSP----AELVSPGDG-CPQSLSAGTGS-LTPGDSGAQGA-LSLTLGA-------D
RAAPAEPSDTALVSAGSSDPENKDPGPPCYISDA-TDCSLTLDCSEGTDSRPGAGEQE--
QGGEGDGSVSSGVGDT--TGG-SQVS-SNPESIPAAEAPA----PA----PVKSEPS---
-CKGG-LPRDRL-AKGKDVT-APKRNSLKEAPPGA--PKPSV-RRGP--------GPAAR
PVRTLTASESESMRKVVPISRASRGAG--GCKRPDAQA--RALPRDPP-NSTDTPWSRRS
SVRGTEQR----PS---------------------RGAGGVRLGREPP-LQRRGSLKKPS
AKPLRNVPR--QKPEENKICRSNSQGPESPEEEPKT-SPAPSVPRVPPAVPSFARNTVAS
SSRSMRTD-ASPAARAPGITRTVSQRQLRVKGG-PEDA-VPKDSGT---LKRASSARAPR
KCPEPA-AGPSARTEAPLKGRGAGERA-SLRLKDSNRTALGKILSPLRK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-APPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPFCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREAQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARPPVA
CLEPEEVRHRDSSFAHKPQ-ASGGQEEAPNPRSARG-HQHPT-AQPE--DPA--SAFRRA
RHQGISVLRKRYSEPVSLGLAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSASSSS-LTPLGRDALGS-LSPALED-----G--
KAARDEPGSAALGSVGSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----AL----SVDSEPS---
-CKGG-LSRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------MAK
PVRTLTTSESESMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVGSRQN
SVRRASDTSPRRTST----GT-----EEQRLLRGSSGSSSSRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPN-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDHPSA-AKAPGITRTVSQRQLRGKGD-PEDT-TPKDSGT---LRRASSARVPK
KRPESA-EGPSANTEAPLQSRGAGERA-SLRRKDSSRTALGRILNPLWK

------------------------------------MHVMNCVSLAGDKENGTLATAAAF
MTGQTSPSASPAPPP-P-PPPPPPCPHSGEGFPPSPPPPLPPP--LPGG--------PPV
---PP-PPPGLPPASYLNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAAKQQHH
YQIDKKTIEELFGQQEDT-SKASLPKRGGALNSSFRDAREEIAVLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCL
IQVPNYSLRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKHNTILLNFSEKLQQVQET
SRLSLDIIEAELHSLFVRTKSLRENIQRDQELRQQMEDFLQFAVEKLAELELWKRELQVE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRLKELEQKRH
SWTTGELGGFGRSS----SENDVQMLAKKGTEDLP--SFLK-PRP------NSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQTRPTIA
WMEPREQETHGPVFTHDPQASKNQEQ---TPHPAWQ-NHLPP-SWLG--EPV--SPSPPA
GRSRPS-LRKRSSEPVGLGTAQ-SPPLLPLDLGIREHELVTGLTQFDLQSPKSLEETSQL
TLNDFCP----TKLPPLGDK-SSQPFDAGGDS-RAPKDTDPREA-LSPAGED-----D--
RAISDEPSSEALVSVVVTDTEDKDPGSLLYVSDT-TDCSLTLDCSEGTDSRPGGDKHR--
EEKEGDGSVSSGAGEA---G-SSQVS-SNPASSPPGEVPA----PK----STKSEPS---
-CQGG-LQKDRP-SRGKDAM-APKRNSFKEASVGA--SKPVSARRSQGV--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPELTSR-A-TPRETP-SSTDTQLSRRS
SVRGTSDTSPRRPQVSGS-GT-----EEPRLPRSS-GSIGGRPGKDPT-LQPRASFRKPS
AKPLRNIPR--QKPEENKVSSPNSRDPESPKEEPKA-PQAPGASRALPPTPSFARNTVAS
SSRSMRADAPPA-ARATGITRTVSQRQLRVKSG-SEDS-ASKDSGT---LKRASSARASK
KCPESA-GGSSANVETPLKGRGTTERS-SLRLKDSGQATLGRILRPLQK

------------------------------------MHVMNCVSLVSDKGNGNIATTAGF
MIGQTPPPPPPPL-----PPPPPPCPYSGKGFPPPPPPPPP---PLPGE---------YL
---FPPPPPGLPPTSHLNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

YSHLGKKKRIRSFFWKTIPEEQVRGKT--NIWTLAAREQHH
YQIDTKSVEELFGQQENT-TKSSPSGRGGPLNSSFREGREEITILDAKRSMNIGIFLKQF
KXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIKKLKAFSGDVAKLSLADSFLHCL
IQVPNCSLRIEAMVLKKEFLPSCSSLYTDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLAXXXXXXXXXXXXXXXXXEAQKKDAVLLNFSEKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKENVQRDGELCQQMEDFLQXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXCLQIFRDFCVKFNNAVKDNHDREVQELRRLQRLKELEQKRH
FWPAGELG-FGRSS----SENDVELLTKRGVEDLP--PFLH-SRP------ISLSYRP-P
NTRRSRLSLSIVADRELLTFLESST--DSP--EELKFHSLPRSCP-------WQAPASGA
RTEPGGQRDQGSSPAHRPP-VSEGQEETPHPTSAWP-GQLPA-PRPE--EPA--PALPRV
RRNGVSILRKRNSEPVGLGSVR-SPPLSPLALGIREHELVTGLAQFDLQAAKGPEELAPL
TVNDFSP----MELASVENE-NPQSLGASNGS-PTPVGRGAQGG-PSPAPGD-------G
SAAPDEPISAAPVSEGSSNPENQD-GSLFYISDT-TDCSLILDCS-GTDSRPEGGDPGXX
XXXXXXXXXXXXXXXX---XXXXXXX-XX-XXXXXXXXXX----XX----XXXXXXX---
-XXXX-XXXXXX-XXXXXXX-XXXXXXXXXXXXXX--XXXXXXXXXXXX---XXXX-XXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXX-X--X--------XXXXXXXX
XXXXXXX--XXXXXX-----X-----XXXX---XX-XXXXXXXXXXXX-XXXXXXXXXXX
XXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXX-PPAPSAPRGPAPVPSFARNTVAS
SSRCQRTDSPPV-ARSPGLTRTVSQRQLKVKGG-PEDA-APKDSGA---LRRAGSVRAPR
KGPESA-EGPGDSAQAPPKGRGAGERA-SFRLKDACRGALGKGLHPLWK

------------------------------------MHVMNCVFLASEKENGDLSAAAGL
MIGQTSPPSPPPPPPP--PPPPLPCPDNGCP-------LVPPPPPLPGG--------PPI
PPPP----PGLP-PSYMNGHGHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 512)

SKTKKMRSFFWKTIPEEQVRGKN--NIWTIAARQPQK
YQIDTKTIEELFGQQEET--KSLVSRRGGPLNASFKDTKEEISVLDAKRCMNIGIFLKQF
KKSPQSIVEDIHQGNGEHYGSETLREFLKLLPESEEVKKLKTFSGDAAKLSLADSFIYFL
IQVPNYSLRIEAMVLKKEFLPSCSSLWDDMTSLRMATKELMSCEELHSVLHLVLQAGNIM
NAGRYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVALEAQKKDVILLNFSEKLRHVQHA
ARLSLDNTESELHSLSARTRSLKENIQRDPELCQQMKAFIKFALQKLEELENWRKDLQKE
AHALIDFFCEDKETMKLDECLQIFRDFCIKFDKAVKDNRDREMQELRQQQKLKGLEEKRR
SWAAGEIGSFGRSS----SENDVELLTKKSPEEVF--PFLH-QRP------FSHSHRP-P
NSRRSRLSLGTSADRELLSFLETA----TGE-DLNKFNSLPRTS-------TRQSKPLVA
WMEPTGSKDVNSNDLSFHPAPA-SEDGHKTPL-IQP-GQLPPDPCLE--NSN--AVLCRT
RNRGNNNNLQRDPGPVG-------PPLPTLTMGVEERELVHDLIQFDAQESRNQEARPRF
ILEDSSP----MESESLEDA-SLPSLTAAADI-PVPAGQDSREG-TKRKNGN--SAPKDV
AADVLSPTSAVSVSTDTSESENKAPEIIFYISDT-TDCSLTLDCSEGNDPKTGSSGSK--
EGKTVNGSMSSGTGDTEGDPSRSRAP-STSSFSPIGEDCA----SA----AGKNEPS---
-YKCG-LPKDKG-VKGKEL--APKRNSLKDTPSSA--SKPSSVRRSL--------GPSSK
TVRTLNASENESMRKVVPINKTSRGSG--SWKRPELGVA-RATPREAA-SGPEVRMSRRS
SVRGTADTSPRRPSGVAVAAA--VAAEEQRLRRGSVFSSSTRSGKDSP-LQSKPSLKKPS
AKPIRNLPK--SKVDETKVCRTNPQESEEAEEVPKPP-PPIPAPRVPPSIPSFARNTVAS
SSRSLKRDSSPPTSKVPGMTRAASQKQLKMKTT-WEDT-QARNGGT---LRRTSSVRNAP
KCPSPG-ENSSSKEEGSLKGKGPGEK--SLKRKDSTRTTLGKILNPLWK

------------------------------------------------------------
------------------------------------------------------------
----PHGGMPPLPPPLTNG

PF02181 // ENSGT00760000118986_0_Domain_1 (140, 512)

HDSHGRKKRMRSFFWKTIPEEQVRGKT--NIWTIAARP--Q
YQIDTKTIEELFGQQEET---KPQDTRSRSLKSSFKETKEEVSILDAKRSMNIGIFLKQF
KKSAESIIEDIYHGRSEPYGSELLNEFLKLLPEAEEVKKLKAFDGDVSKLSQADSFMYLL
IQVPNYALRIEAMVLEREFSPSCASLQDDMKIIRRATKELMTCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMSLLHFVALEAQKKDAALLNFSEKIRDVHDA
ARLSIDNLEAELQSLSFKARSVKDSIRRDPKLFYQMESFLQFAVRHLKELEHQKRELQKE
GNALIDFFCEDKETMKLDECFQIFRDFCIRFNKAVKENREREIQELHHLQRRKELEEKRR
SWAAGELGSFGRSS----SENDVEMLAKKGLEEFL--PFLQ-QRP------QSPSYRN-P
NSRRSRLSLGITADRELQSFLEISK----DE-DPNKFNSLPRAN-------TRQARPNVA
WTESKETKDLNLNTLHLHQQSETKG-KRGDHLQLPP-AQSSHFGG----SAGP-GARYPP
RSTNYNT--HT-----SNASCEESADINALALAIEEHELVKGLRKFDIQGAKPAEDTPLI
YLEDVGG----TDLETLDDL-SLHSLSTADDDL-PPACRSSREAHDHK---A---KAVGC
KSEASEPSSSSPMSLDTSVSGSRDDGPMFYVSDTTTDCSLTLDSEEGNDFKSVGNEVRSE
AGK-----ARSSVSGAQYRS--RTLF-SNLNTASAKDLSP----------HASTNDKDDA
NSKHM-LSKEKS-VKNKDAI-GPKRNSLKDRSPSS--SKSSGTRPSHTA--------SSR
PVRTLNASENESMRKVVPISRSNKP--PSSVKKPEAKPALRE------TSTVESRLSRRS
SVRGTTDTLPRSPYRHSV------SVEEPRLQRGTVTSSSAHFERDR--VA----LKKPV
SKPIRSTVK--SKTDEIKICRSSVKPQTPADDTKVA---PVTVPKTPSTVPSFARNTVAS
SSKRAKVD-LSSSSRPPTITRSVSQRLPKAKPAATSDETSPKENG-GSTLKRANSARAVG
RSLLQG-DTVSTKVEPSAKEQGMEEKS-SLKLKDANRTTIGKILKPLLK

KTVGELEDYQLFYKWVILCTKLPQGQEIVSLEGYSTMHVINCVSLVGDKENGNVTTAAGL
MTGQTPPPAAPPPPPPP-PPP-------------------PPTPVSPGG--------PPV
----PPPPPGPPPPSHTNKYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

EKKRMRSFFWKTIPEEQVRGRT--NIWTLVAEQQHN
YQIDTKTIEELFGQREDS-TKGSLSKRRGTL---LKDAKEEITLLDVKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGSETLREFLKLLPESEEVNKLKTFSGDVSKLSLEDSFMYNL
IQVPNYTLRIEAMVLKKEFLPSCSSLNTDIAILRAATKELMSCEELHSILHLVLQAGNIM
NAGRYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDASLLNFSEKLCHVQEA
ARLSLDNTEAELHSLLARTRTLKENIQRDGELCQQMEDFLQFAVEKLTKLERWKQELQKE
AHILIDFFCEDKETMKLDECLRIFRDFCAKFNKAVEDNHYREVQELRRQRRLRELEQKRN
SWAAGELGVFGRSN----SENDVELLTERGAEPLP--FLQR-RKP------TSPSCWA-P
HARRSRHSLGISAERELLTFLEG-SA-DGPG-QSGKFSTLPRSP-------LQQARPAAA
WPEPAEPRDLGAKLAPRPRAWE-RQEEAPGPASASP-VPHPP------------------
------------------------------------------------------------
---SQKP----VELASLEAG-RLPPPSAGDGA-LRAEE---------------------D
LGPAAHAGSAALVPVGSGGPGPGDPEPPGCPSH-------PPGCSEGTDLSPGGGEPE--
EGQEGAGCVSPGAGE---AGD-GQVS-PQPAPGPPQGAAA----PG----PAVGLPS---
-CKGA-LPRGRP-TKDKDGT-APKKISLKEASARS--PKHEGVRQSQ-------------
-----SISEKESMCKIVRIPKSSRGPG--DWKRGSFR--------ETP-SSTDALLSRRS
SVRRAADAALRGLSAG----------EDRRPPPAGSGSGSGRPGKEHP-VQQRGSL-KPT
AKPLRYAPR--QKPEENKGCHANSQGSESSEEEPKA-PAAPSAPRAPATVPSFARSTIAS
SSRNTKTD-PPTATKAPGITRTASQRQLRVRGG-SKDA-ASKEGSM---LRRAASVSAPR
RGPETA-EGPSAKLEAPLKD-RSGVRA-ALRLKDSSRTTLGKILNPLRK

------------------------------------MRVMNCVSLASDKGNGTIATSAGF
MIGQTPPPAPPTLSTPP-PPPPLPCPLSGGALSSPS--PP--------------------
---PPPPPPGPPLAPHPQSFSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWNTIPEEQVRGKA--NIWTLAAGEQHH
FQIDTKTIEELFGQQEDT-AKPSLPKRGGPLSSSFRDTREEVTILDAKRNMNIGIFLKQF
KKSPQSIVEDIRQGRSEDYESETLREFLKLSPKSEEVKKLKAFSGDEAKLSLADSFLRFL
IQVPNYSLRVEAMVLKKEFLHSCSSLHTDMTVLINATKELMSCKALHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDASLLNFSEKLYHVQEA
SRLSLDNTEAELKSLSVRTKSLEENIKRDGELCQQMADFLQFATEKLTELDRCREKLQRE
AHTLIDFFCEDKETMTLDECFQIFRDFCTKFNKAVKDNRDREVQELRQLQRLKAIEER--
--LPGELGGFVRSN----SEADMALLTRKCTENLS--QLSH-PRP------DSPYLRP-P
NIRRSRHSLVVPTDQELLSFLKS-A-------N-PKFNTLPWRH-------RRQARPEVA
SGQSGDAGG-HPTFAQR-PQAS-PAPQP------------------T--EQP--PALPRA
RH-RAGTLQKRSSEPSGLGASR-TPSLSSLTLGVQEHELVTGLAQFSLEDPKDTQESARP
PQNGAGS----GL--SPEPG-SLLSTSAGHTG-EMPMCRSPQEG----LHPA-------L
EATAAVPGS---EASGSMGSSSSEQGDPASVSDT-TDCSLTLDCSEGTNLGV----G---
-------------------GQ-GPGE-A--------------------------------
--RGG-SA------------------------------SSGSGAVGH--------S----
--------------------------------LASPQL--TPN----P-T-KSETPC---
------KRT-----------SE----D-PRPAR-GSG--GGRPGKEAA-PQPRGSLRKPS
AKPLRNVAR--QRPEENRAG-------PAEPRSPEE---KPRVSRPPSNMPSFARNTLAS
ASRCVRPE-PA----HPGLTRAASQRQLRARGP-EDCA-PK-DGGA---LRRTRSARTTQ
RS------------PEPFE-RRVREPG-SPRRRGSARTTLGRMLDPLWK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPSASPPPPP-P-PPPPTPCPHSGEGFPPSPPPPLPPP--LPGG--------PPV
---PPPPPPGLPPVSYLNGYSSL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKRRMRSFFWKTIPEEQVRGKT--NIWTLAAKQRHQ
YQIDEKTIEELFGQQEDA-SKASLPKRGGALNSSFRDAREEITVLDAKRSMNIGIFLKQF
KKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKTFKGDASKLSLADSFLYCL
IQVPSYSLRIEAMVLKKEFLPCCSSLFKDIRILRAATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTRANKPGMNLLHFVAQEAQKQDAILLNFSEKLQHVQET
SRLSLDITEAELHSLFVRTKSLQENIQRDQELCQQMEDFLQFAVEKLAELELWKRELQGE
AHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKELEQKRY
SWTSGELGSFGRSS----SENDVQMLAKKGTEDLP--SFLK-PRP------NSPSYRP-P
NTRRSRLSLGISADRELLTFLESAT--SSPE-DPNKFNSLPRSSP-------RQARPTIA
WMEPREQQSHGPTFTHEPQASKNQEK---APAPAWQ-NRLPT-SWLE--EPA--SPFPLV
GRSRPS-LRKRNSEPVGLGPTQ-SPPLLPLDLGVREHELVTGLTQFDLLSPKSLEEASQL
ILNDFCP----TKLPSPGDR-SSQPFDAGGDS-LPPKDTDPQEA-FSPAGED-----D--
RAISDEPSSEALVSVVVTDTEDKDARSLLYVSDT-TDCSLTLDCSEGTDSRPGGDKQE--
EEEEGDGSVSSGAGEA---G-SSQVS-SNPASSPPGEVPA----PK----SSKSEPS---
-CQGG-LTKDRP-SRGKDAM-APKRNSFKEASVGA--SKPVSARRSQGV--------APK
PVRTLNSSENEHMRKVVPISKSSRGAG--PWKRPEPTSK-A-TPRETP-SSTDTPLSRRS
SVRGTSDTSPRRPQVSGS-GA-----EEPRLPRSS-GSISGRPGKDPP-LQPRASFRKPS
AKPLRNIPR--QKPEENKISNPNSRDPESPKEEPKA-PQATGVSRALPPIPSFARNTVAS
SSRSLRTDAPPA-ARTTGLTRTVSQRQLRVKGS-SEDS-ASKDSST---LKRASSARASK
KCPESA-GGSSANVETPLKGRGTTERS-SLRLKDSGQATLGRILRPLQK

------------------------------------MHVMNCVSLASDKENGTLATAAAF
MTGQTSPPASPPPPP-P-PPPPLPCPHSGEGFPPSPSPSPPLPPPLPGG--------APA
---PP-PPPGLPPASHTNGYST

PF02181 // ENSGT00760000118986_0_Domain_1 (143, 511)

LGKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQQRH
YRIDTKSIEELFGQQEDP-AKASFPRRGGSFSSSFRDARDEITVLDAKRGMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREILKLLPEVEEVKKLKTFSGDVSKLSLADSFLHSL
IQVPNYSLRIEAMLLKKEFLSSCSSLYTDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKHDAVLLNFSEKLHHVQEA
ARLSLDNTDAELHSLVVRTRSLQESIQRDGELSQQMEDFLQFAMEKLMELEVWERELQGE
AHALIDFFCEDKETMKLDECFQIFRDFCIRFNKAVKDNQDRQVQELRQLQRLKELEQKRR
SWAAGELGAFGRSS----SENDVELLSQKGTEELP--SFLH-PRP------ISPSNRP-P
NTRRSRLSLGMSADRELLTFLESAT--GSPE-DPEKFNSLP-----------RQARHTIA
WVAPREHRSHDPNFAHAPQ-ALESQVA--APHPAGQ-NQLPV-PQQE--EPV--SVSPRT
RRDGVRVLRKRNSEPVGLGPSW-TRPLSPLALGIKEHELVSGLAQFDLQSSKCPPETSHV
ALSDLSR----KELESPGDG-DTLSLGVASDS-RTPTASQE-AP-VSAALED-------D
SVAPEEPSGGALVSAGGSDPEDSDHGPTLNVSDA-TDCSLTLDCSEDTDSRTGGAQPE--
EESPGDGSVSPGAGDT---G-SSEVS-SNPAPSPPGEAPH----SV----SGKGDPG---
CCEGA-LPRDRP-SKGRDAP-GPKRNSLKESSPGS--AKPGSARRSQGP--------ASK
PVRTLTSSENESMRKVVPISKASRGAG--GWKRPEPSVR-GA-PREAP-GGPDPLLARRS
SVRGTSDTSPKRQPLGAGPVA-----EEPRVPR-----GGAKLGREPT-PGHRVSLKKPS
AKPLRNMPR--QKAEEIKACHPDPQDPESLPEELKA-PAAPSVPRVPPPIPSFARNTVAS
SSRCLRTDSPQV-TKAPGITRTVSQRQLRVKGG-PEDV-ASKDGGT---LKRASSARSPK
KGPESA-EGPSANVETLAKGRGSAERA-SLRLKDSGRATLGRILHPLRK

------------------------------------------------------------
------------------------------------------------------------
----------------------------

PF02181 // ENSGT00760000118986_0_Domain_2 (149, 276)

MRSFYWNTIPEEQVRGKT--NIWTLAGREQHH
FQIDTKSIEELFGQQEDI-AKASVPKRGGTLNSSFRDAREEITILDAKRNMNIGIFLKQF
KKSPRSIVEDIHQGKSENYGLETLGEFLKILPESEE------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PLPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEREQKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-TSGGQEEAPNPPSAQA-HQLAA-AQPE--DPA--SAFPRA
RRQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MELESVGHR-GPQSLSASTSS-LTPMGSDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVEEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------VAK
SVRTLTTSENESMRKVMPITKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRA--------ST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PSVPSVPHELPRVPSFARNTVAS
SSRSMRTDLPPV-AKAPGITRTVSQRQLRVKGD-PEDA-APKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGRILNPLRK

------------------------------------MHVMNCVSLVSDKENGTITTAAGF
MIGQTPPPASPPPPPP--PPPPPPCPHLGEGFPPSP--PPPLPPPLPGG--------PPV
----PPPPPGLPPTSHMNGYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFFWKTIPEEQVRGKT--NIWTLAASQQHH
YQIDTKTIEELFGQQEDP-SKSSLSRRGGTLNSSFKDTREEITILDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKIEHYGSETLREFLKLLPESEEVKKLKTFSGDVSKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITILRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMDLLHFVAQEAQKKDAILLTFSEKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFAIEKLTELEHWKRELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCTKFNKAVKDNHDRAIQELRQLQRLKELEQKRR
SWAVGELGGFGRSS----SESDVLLLTQKGAEDLL--PFLH-PRP------ISPSYRP-P
NSRRSRLSLGVSADRELLTFLES-ST-SSPE-DNSRFNSLPRSS------SPGQNRPTLA
WMEPAEPRDPNSDFGRKPQASE-GREKAPLA-----------ATQRE--EAA--GASPRA
ARGGYSLLRKRYSEPVGLGQAR-SPPLPPLALGIKEHELVTGLAQFNFQGPKIPEETSRL
TSNDFSP----AEIGSPGDE-RPQTLSAGHQG-AL-------------------------
SLAPEEPGDSALVSAGSSDPDNKDPGPVFYLSDT-TDCSLTLDCSEGTDPRPAAGERE--
GGGEGDGSVSSGAAE---AGS-SQVS-SRAASSPPAEAPD----PV----SEKSEPS---
-CEAG-LPRDSP-AKGKDVT-TPKRSSLREAPAGA--PKPGGIRRGQ--------VPAPR
PVRTLTASESATMRKVVPLSKTGRALG--GWKRPEPQG--RAPPGDAP-GGTDTLWSRRS
SVRGTKDTSPRRPSAGTRVAPE----E-QRPPR-GGGAISARQGKEPQ-LQRGGSLRKPS
AKPLRNVPR--PKPEEDKICRSHSQDPESPEEQPKT-PPAPSVPRVPPPVPSFARNTVAS
SSRSMRTD-TPPAARAPGITRTLSQRQLRVKGG-PEDA-ALKDSGT---PKRASSVRAPR
KCPEPA-EGPGAHTEASPKGRGAGDRA-SLRLKDSDRTTLGKILSPLRK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-PPPGLPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLKEQEQKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSPE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-ASGGQEEAPNPPSAQA-HQLAA-AQPE--NHA--SAFPRA
RRQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MELESVGHR-GPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------VAK
SVRTLTASENESMRKVMPITKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRA--------ST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PSVPSVPHELPRVPSFARNTVAS
SSRSMRTDLPPV-AKAPGITRTVSQRQLRVKGD-PEDA-APKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGRILNPLRK

---------------------------VISLEGSSTMHVMNCVSLVNDKENGNIAMAAGF
MIGQTPPPPPPPPP-----PPPPPCPYSGEGFPPSPPPPPPPP--LPGG--------PLV
---PP-PPPGLPPTSHVNGYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQKHH
YQIDTKTIEELFGQQEDT-TKSSPSRRGGSVNSSSRDAREEITLLDAKRSMNIGIFLKQF
KKSPQSIVEDIHQGKSEHYGAETLREFLKLLPESEEIKKLKTFSGDVCKLSLADSFLHCL
IQVPNYSLRIEAMVLKKEFLPSCSSLYKDITILRTATKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDAILLNFSEKLHHVQEA
ARLSLDNTEAELHSLFVRTRSLKENIQRDGELCQQMEDFLQFAVEKLTELERWKGELQDE
AHTLIDFFCEDKETMKLDECLQIFRDFCIRFNKAVKDNHDREVQELRQQQRLKELEEKRR
SWAAGELGGFGRSS----SENDVEQLTKKGAEALP--SFLH-ARP------VSPSYRP-P
NARRSRLSLGLIADRELLTFLESST--GGPSKEPARFHSLPRSSP-------RPAGPTVA
WTDPAEPRGQDSGRAHRPG-ASESREEAPESPSAWQ-SQPPA-PGPA--EPA--SASPRA
QRGGSSILRKRNSEPVGLGPAR-SPPLSPLALGIKEHELVTGLAQFDLQGSKGPETP-RL
ILNDSSP----MTS------------LGDGSR-LTPVGRGAQAG-RSPAPGG-----D--
GAAPDEPSSAALVSVGSSDPESKDPGSLIYISDT-TDCSLTLDSSEGADSRPGPGERE--
AGGERDGSMSSGAGET---A-GSQVS-SNPASSPPREAPA----PV----SVKSQPS---
-SKGG-LPRDRP-AKGKDVM-GPKRNSLKDASQGA--SRPASARRGQGA--------APR
PVRTLNASESESMRKVVPLSRAGRGPA--GWTRPPRDT---------P-GSTDAPWSRRS
SVRGTSETSPRRPSTGSGAVA-----EEQRLPRASGSSSSARPGKEPP-LQRRGSVRKPS
AKPLRNVPR--QKPEDSKICCSNSQGLGRPQEEPRR-PPAPSVPRVQAPIPSFARNTVAS
SSRSTRTEAPSV-ARAPGITRTVSQRQLRVKST-PEDA-APKDSGA---LRRASSARAPK
KCSESS-AGSSTNTEAPLKGRGAGERA-SLRLKDSHATTPRNILHPFRK

------------------------------------MHVMNCVSLASDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PAPSPPCSCSREECPSSPPPPPPPP--LPGE--------PPI
---PP-APPGPPPTTHMNGYSHL

PF02181 // ENSGT00760000118986_0_Domain_1 (144, 511)

GKKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELRLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARPPVA
CLEPEEVRHRDSSFANKPQ-ASGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGLAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSASSSS-LTPMSRDALGS-LSPALED-----G--
KAAHDEPGSAALGSMDSSDPENKDPRPLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNRTSSPPGEAPA----AV----SVDSEPS---
-CKGG-LPRDKP-TKRKDVV-APKRGSLKEASPGA--SKPGSARRSQGA--------MAK
PVRTLTTSESESMRKVMPITKSSRDAS---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRA--------ST----GA-----EEQRLPRGSSGSSSSRPGRDFP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPN-EPKT-PPVPSIPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRGKGD-PEDT-TPKDSGT---LRRASSARVPK
KRPESA-EGPSANTEAPLQSRGTGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------------------------------
------------------------------------------------------------
----------------MNGYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPRRGRTSNSSFRDAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAVEKLRELECWKQELQDE
AHTLIDFFCEDKKTMKLDECFQIFRDFCTRFNKAVKDNHDREVQELRQLQRLKEQEQRQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPISP---ASPSYRP-P
NTRRSRLSLGPSADQELLTFLESST--RSPE-EPNKFHSLPRSSP-------RQARTTVA
CLEPEEVRHRDSSFAYKPQ-ALGGQEEAPNPPSARG-HQHPA-AQPE--DPA--SAFRRA
RHQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MEPGSVGHG-VPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
TAAPDEPGSAALGSVGSSDPENKDPRLLFCISD--TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSNPPGEAPA----PI----SVDSEPS---
-CKGG-LPRDKS-TKRKDVV-APKRGSLKEASPGA--SKPGSVRRSQGA--------MAK
PVRTLTASESEGMRKVMPITKSSRDAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRTST----GA-----EEQRLPRGSSSSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPK--QKPEENKTCRSHSEGPESPK-EPKT-PPVPSVPHELPRVPSFARNTVAS
SSRSMRTDLPPA-AKAPGITRTVSQRQLRVKGD-PEDT-TPKDSGT---LRRASSARASK
KRPESA-EGPSANTEAPLKSRGAGERA-SLRRKDSSRTTLGRILNPLWK

------------------------------------MHVMNCVSLVSDKENGNIATAPGF
MIGQTPPPAPPPPPP-P-PPPSPPCSCSREECPSSPPP-PPPP--LPGE--------PPI
---PP-PPPGLPPTTHMNGYSHLG

PF02181 // ENSGT00760000118986_0_Domain_1 (145, 512)

KKKRMRSFFWKTIPEEQVRGKT--NIWTLAARQEHH
YQIDTKTIEELFGQQEDT-TKSSLPGRGRTLNSSFREAREEITILDAKRSMNIGIFLKQF
KKSPRSIVEDIHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGNVSKLSLADSFLYGL
IQVPNYSLRIEAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIM
NAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLDHVQKT
ARLSLENTEAELHLLFVRTKSLKENIQRDGELCQQMEDFLQFAIEKLRELECWKQELQDE
AYTLIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNQDREAQELRQLQRLKEQEQKQR
SWATGELGAFGRSS----SENDVELLTKKGAEGLL--PFLH-PRPLSP---SSPSYRP-P
NTRRSRLSLGPSADRELLTFLESST--GSLE-EPNKFHSLPRSSP-------RQARPTIA
CLEPAEVRHQDSSFAHKPQ-ASGGQEEAPNPPSARG-HQLPA-AQPE--DPA--SAFPRA
RRQGVSVLRKRYSEPVSLGSAQ-SPPLSPLALGIKEHELVTGLAQFNLQGSQGMEETSQL
TLSDFSP----MELESMGHG-GPQSLSASSSS-LTPMGRDALGS-LSPALED-----G--
KAAPDEPGSAALGSVGSSDPENKDPRPLFCISDT-TDCSLTLDCSEGTDSRPRGGDPE--
EGGEGDGSMSSGVGEM---G-DSQVS-SNPTSSPPGEAPA----PV----SVDSEPS---
-CKDG-LPRDKP-TKRKDVV-APKRGSLKEASPGT--SKPGSARRSQGA--------VAK
PVRTLTASENESMRKVMPITKSSRGAG---WRRPELSSR-G-PSQNPP-SSTDTVWSRQN
SVRRASDTSPRRSST----GA-----EEQRLPRGSSGSSSTRPGRDVP-LQPRGSFKKPS
AKPLRNLPR--QKPEENKTCRAHSEGPESPKEEPKT-PPVPSVPHELPRVPSFARNTVAS
SSRSMRTDLPPG-AKAPGITRTVSQRQLRVKGD-PEDA-APKDSST---LRRASSARAPK
KRPESA-EGPSANTEAPLKARGAGERA-SLRRKDSSRTTLGKILNPLRK