ENSGT00760000118933_0 : Linker Region Query Results

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--------------------LFG--------------------------------FCSS-
------------------------LRHFQDPSPSF-----F-----PPSLPCLF-----K
IFF----------------------------------------------------V-CH-
--------T-GDAGKFYLVSLGDTAELLCPLSLWPMTVPE-QVRWLRPSHQQ-DSQ-AVH
LFLGGKDRNED----VRLEYKGRTEL-VRDL-QEGKV-SLRIRNVSLEDKGQYQCQ--IQ
-V-G--NLTREG-TVT------L--Q-VA-----AS------------------------
--------SFYLHG-WS-K---L---THSVGWFRKLWDNWRNPDA-GRFHPC--------
---------------------------------------LTVPSRVR-----D--IPPGG
NVSC-IVCNVV-FSR-EKSTG--------------------------------VVI----
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-----------------------------------------------------AIPSSER
L---S-----S---------------------ST-VALAVV-LPV-----LLLFITAS--
I-----YVIWKQRRSKEKLLYE--QALQVE-NLLEDHAKEKGTS----------------
---------------------------------LQH------------VVL---------
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-------WETFMIPTT-----------APFSCLSGWRRARLHFEAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--QT-V------------PNN--
PQRFDFVVSIL-----------GSEY FT---AGC HY---WE-VH-V------GGKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------ITASPANGHWLVRQC----------GRNEYEALTSPQT------Y
---------------------------------FRLKEPLR---CVGIFLDYEAGIISFY
NVTSKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---ENTAPLIIC-SEL-QKSEEST
VPKP---------------------------------------------------KEKA-
-HANGDVALKVNPS---LLPPQSPEL--FPLN---DVILSWPSDLGPALQKLKVPS----
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---------------------------MARA-HPGD-ATLPSI----LVS---FIF--LQ
LLTSG----------------------------------------------NGKSD-FLV
--------L-GPP-HPLLAIVGQDKELPCKLSLNISAEGM-ELRWYRDKP-S---S-VVH
VYKNGEDVYDE----QMVEYKGRTSF-NGSHVARGEA-AVKIHNVTVFDNGTYHCV--FK
-E-Y--TSHSQA-TLW------L--K-VA-----GRGSSP-----------------RI-
------RVTDTQDK-GI-R---A--ECTSAGWYPEPKVEWLDLKG-QPVSA-E-------
------S-------------------HF-SVSASTGLVALLSIVTPQ-----D--TAVG-
GLTC-SISNPL-LPE-KDTG----F---LA---AVVKV----------------------
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---------------------------------------------SV-----S-GAHTGN
I---GQSV--Q----------------S--H--GS-----I-IKS---------------
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--------------------------------------SESFSVKVP-------------
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-------YVA----------VWK--------------------------------MCVMS
RSQK-------------------TSVHMERPPSTS-----G-----SWLLGCLL-----T
LAFLQLPA-------------------------------------------PV-------
--------S-GDADKYYHVPLGGTAELSCPLLLWPGMVLS-EVRWQ---HLPHT-Q-AVH
VLRDGQDSDED----LMPEYKGRTKL-VRDT-HKGSY-TLHISNVRLEDRGLYQCQ--FR
-V-G--NQSQEG-NVT------L--Q-VA-----VLGSDP-----------------FI-
------HVKSYDAG-WI-Q---L--VCQSMGWFPKPWTEWRDTEG-RVLQSLT-------
--------------------------EA-HSLDETALFQTAVSSRVR-----D--NAVG-
NVSC-TVRNEV-LGQ-EKTTI--------------------------------MVI----
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-----------------------------------------------------GAPAPGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLLILLG--
I-----WLICKQKRSKGVLFAF--PFLCLE-NLLEDHAKEK-GM----------------
---------------------------------YR-------------M-----------
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------------------------------------------RMVVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDK----K--RP-V------------PDN--
PQRFDFVVSVL-----------GSES FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RRNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---RNTAPLIIC-TEL-QKSDESI
VTKQ---------------------------------------------------EGKS-
-QANGDVSLTVNPS---LLSPQGSKL--FPVN---DT---WPSNLGPALQGFKAPSL---
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---------------------------MGST--GL---RFY--------GHC------VA
MFLLQ-MI------------------------------------------TPSSEQ-FTV
--------T-GSE-GPFLAPLGGTLELSCQLSPPQNAQHM-EIRWFRNHY-T---Q-PVH
LYRDGKDLHGE----TTSKYVERTEL-LKDAIGEGIV-TLRILSVTVDDDGPYHCV--FK
-D-G--DFYEEH-ITE------V--K-VT-----GRHGSF--------------------
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---------------------------TEM-ANSS-----G-----SWLSSCLV-----A
LMFLRLPL-------------------------------------------PL-S-----
----------GDADDYHLAPLGGTAELPCPIPLWPVTVPT-AVTWLRSPSPD-RSQ-VVH
VFRDGRDREEG----VMPEYKGRTAL-RRDP-GEGSV-SLEIRHVRLEDRGLYQCE--VQ
-I-G--NLTRDG-IVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-Q---L--VCRSAGWFPQPLAQWKDPQG-RVLQPLS-------
--------------------------DV-HVL-EAGLFRIAVSSRVR-----D--STLG-
NVSC-TVHNLA-LGQ-EKTTA--------------------------------MLI----
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-----------------------------------------------------AAPSPGR
I---S-----S---------------------ST-VALAVI-LPV-----LGILIIVG--
I-----YLIWKQRRSKEKLLYE--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
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-------KKLRSELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRRVKLGDR----R--QP-V------------PDS--
PQRFDFVVSVL-----------GAEYFT---AGCHY---WE-VD-V------GDKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------ITATPANGHWLVRQS----------SEKEYEALTSPQT------T
---------------------------------LRLKEPPR---CVGIFLDYEAGIISFY
NVTSRSH--IFTFTHTF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEPPT
VCKP---------------------------------------------------EEKG-
-HANGDVTMNVNPS---LFPLQAPEI--FPPR---DMILPWPSDLAPALQGLKVPSF---
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---------------------------MEPA------AALPFS-----LPASLLL-----
-LLLSLRA-------------------------------------------LVSAQ-LTV
--------V-GPT-DPILAMVGENTMLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRHRTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSSDEA-ILR------L--M-VA-----GLGSEP-----------------LV-
------EMRGHEDG-GV-L---L--ECISRGWYPKPLTVWRDPSG-EVMPALK-------
--------------------------ED-STPDADGLFMVTTAVIIR-----D--RSVR-
NMSC-SVNNTL-LGQ-KKESV-------IFIP-ESFMP-------SASPCVVALPV----
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----IV-------------------------------------LILMIP-----IAV--C
I-----YWINRLQTEKKML-SG--------EKEFEREMREIAVKDLE-------------
------------------------------------------------KERVE-------
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-----------KE----KEL----------------------------------------
-QR---KEQLQEELRW--------------------RRAFLHA--------------TAH
PELF----------LS-----EDRRSVRR--GPYR----QS-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVLVWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------FLLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSIF-S-VPMRPFFRLGSDDSP-------I-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHHSPQ----------------------------------
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-------------------------------------------------------MVAIP
---N-------------------IPHSFQSS-------SLSSC------LL---------
-LLLYLME------------------------------------------LN-AE-----
----------------------------------MDAQDM-TVNWFRNKT-------LVY
RYPIGEKLEES----QGTQSQGWTML-LKHDLADGKV-TLKIQQVQASDSGPYACQ--FQ
-S-P--DQSE-A-HTE------L--Q-VA-----GLGSDP-----------------HI-
------YFEGLEEG-GI-Q---M--RCSSKGWYPRPMAVWKDDQG-QQLPS-L-------
------S-------------------ET-ITQDSQGLFHLEISVVVK-----E--GDHS-
SVVC-SIQNTL-LVQ-KKEFT-------VHIA----------------------------
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X---XXXX--X----------------X----XXX-XXXXX-XXX-XXXXXXXXXXX---
-----------XXXXXXXXXX--------XXXX-XXX---XXXXX-----X---------
-----------------XXXXLFS----DWRRAEGQ-----AEWR---AARRHA----VN
I-----------------------------------------------------------
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----------------------------------------------T---L--D-SDTAH
PNLK----------VS-----EDGKSVIYCNK------KQD-L------------PDD--
PKRFEDQLSVL-----------GQEGFI---SGKHY---WE-VE-V------REKSRWFL
GVCYDSVE-R--K-EE--------------------------------------------
---------------VKLCPQTGYWVMGLW--N--------GCEYFIFNPH-R------V
--------------------------------SLTLRVPPR---RVGVFLNYEAGKVSFF
NVTDNSH--IFTFTDKF--S-GTLRPYFRPRSHDGG---EQAIPLTIC-SLP-NKGDRVA
VKD----DDDWDTWLQ----------------------------PY--------------
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-------------------------------------------------------MADFS
---V-------------------SLGFLKQV-------PWCSS------VFFLTHLLL--
--LLQPGE------------------------------------------GN-AGS-VWV
--------L-GPG-ESMLALVGEVVEFPCHLSPHQDAEHM-EISWFRSQA-S---D-IVY
LYQERQELSNR----QMPEFQNRTKF-DAQEIRDGSV-ALHLFNIVPSDEGPYGCR--FL
-S-P--DFSGEA-FWE------L--E-VA-----GLGSDP-----------------LI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPKVQWRNHQG-QCLPP-E-------
------S-------------------EA-IIQNVQGLFSLETSVTVR-----E--GAHS-
NVSC-SIQNPL-L VQ-KKEFV-------LQIA-GHGKCFLQQGQ-TSSQWAFK-------
----------------ALLP------------SLLTK---SKSLAVAPDPTWRRPCSCPH
APFT-HGFRGPTEGVT-----------------GHPKVIE--TT----------NFLWDV
F---LPRT--S----------------P----WKK-AFLGT-LVT-LPLLLAILTMLA--
L-----QYFYKQRSSQGMSQA---------------------------------------
---------------------PRA----DWRRT-----------------EGQA----VD
V-----------------------------------------------------------
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----------------------------------------------T---L--D-PDTAH
PSLE----------VS-----ADCKSASSR---LRAS--NA-D------------PGD--
PRRFSEQTCVL-----------SRQH FA---SG RHY---WE-VH-V------GRRSRWFL
GACLASAP-R--S-ET--------------------------------------------
---------------ARLSPASGYWVMGLW--N--------SCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RVGVLLDCDAGKLSFF
NASDGSH--IFTFTDTLSAS-GALCAYFRPRAHDGS---EHPDPLTIC-SLP-VRGQHAL
EEN------DSDTWLQ----------------------------PY-EVS----------
-----DPALG-------LW-----------------------------------------
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---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIKWSDTKG-ENIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGG-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
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----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATE-------------
----------------QEIS---------LREKLQE-E---LKWR---KIQYMA------
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----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHASF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-KEVESSP
-D--P--D-----------------------LVPD--------HSLETPLT------PGL
ANESGEPQAEVTSL---LLPAHPGA-EVSPSA--------T-TNQNHKLQARTEALY---
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-----S------------------------PCSAVR-PALPGY------LVLCL------
--AVQAHS-------------------------------------------LASAQ-FSV
--------T-GPD-HPISAVVGGEAVLSCHLSPRMSAANM-EVRWFRSQF-S---A-AVH
LYRDGQDQNKE----QMPEYRGRTEL-LKDNITDGRV-SLRIRDVQPSDDGQYKCF--FE
-S-S--VSYEDA-LLE------L--Q-VA-----AFGSAP-----------------DV-
------FVEGHQDG-GV-R---V--VCQSSGWYPQPEALWRDLQG-QHLPS-D-------
------S-------------------EK-ISPEASDLFQIEIAIVLR-----E--ESNQ-
KVSC-HVWNPR-LDQ-EREST-------ISIA-G--------------------------
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F---FPRV--N----------------P----WMV-SLWVI-LAV-----LAVLITLA--
S-----YCSWRQHRAKGKVRK---------------------------------------
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----------L--------------------------------------CLYFPGK-FTV
--------I-GPQ-QPIIALVGGETIFPCYLSPQINAQDM-DVMWFYGES-S---Q-VVH
RYKYRQDYLNH----QHQDYKGRTEF-LRHDISTGSV-ALKICHIRPSDEGKYRCY--FE
-S-S--SAYGEA-EYQ------V--F-VA-----GEGSVP-----------------HI-
------YIVSDGNQ-NL-K---L--VCTSTGWYPKPEVQWRKNQE-KLLPQ-D-------
------T-------------------TI-K-KKENGLFSVETSIMVS-----R--NSTG-
NVSC-FILNPL-LRQ-KLEAS-------VSVS-D--------------------------
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L---FPHN--T----------------P----WIV-IWIVT-VVL-----FSTVI-FI--
I-----IFVTWKLKK-GK------------------------------------------
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---------------------------MEPA------AALHFS-----LPASLLL-----
LLLLRLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DSILATVGEDTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-------------------------------
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----------------KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
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----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLRKEKKI-LSG--------EKEFELETREIAVKELE-------------
------------------------------------------------KERVQ-------
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-----------REK----EL----------------------------------------
-QV---QEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVQ-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-IGASGVT
VPE--------EGLTLHRVGTNQSL-----------------------------------
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----------------------------------MKKMVGFPEYFTARH--FIILLLFLQ
LPTLCSARFSVVGPAGP-VLARLGGVAVLPCHLVSKESAEKMEVRWFRTQPSNIV-HQFK
DQKDVFGEQMKEYQGRTEMVKH-AIDKGNVALRIRNIGLSDEGKYHCSFSGDTEQGETTM
ELQLVVMGKSWGKHNN---------GK---CE---------------------------E
KRENFTVPGGWI----------LGTG---VI---WKFFLGTLW-----------------
-PFLTEDQIHLTI--------------------------------H------------PF
L----VVLRETV------------------------------------ETFCFVLN----
NYHYDAPP------------------------------SSV--IVPEP-LRDEVRE-FSV
--------I-GPA-EPILALEGKDVELPCHLKPKMNAESM-EVRWFRSQP-S---D-IVH
LYENRKDRFQQ----QMEEYHKRTKL-VTDAMDYGSV-AVRVYNVTVSDEGQFRCS--FY
-N---GQVSEVA-TLE------L--Q-VV-------------------------------
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---------------------------------------------------------FAV
--------K-GPL-EPVVALLGGDATLPCQLSPEQSATHM-DIRWYRAQL-S---P-AVL
VYQNGQEQGGE----QMLEYRGRTEL-AEDTIGTGSV-SLLIEQIRASDNGQYRCL--FK
-D-G--DISQEA-IVE------L--N-VI-----GLGSAP-----------------HV-
------HMTGLENG-GI-R---V--LCSSGGWFPKPKVQWEDMTG-VKLPS-L-------
------S-------------------EY-QTQDGDGLFHVEASLVVT-----D--SSMG-
NVTC-SIQNPL-SGQ-EKVSA-------IFLP-E--------------------------
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-----------------------------------------------------------P
F---FPRM--S----------------P----WKA-ALAGT-LPV-----LGLLLIGT--
S-----YIGWREHQAKHREIK--------KRKQEAAE-RDQVKNEKRIA-LEAK------
------------ET-----LEADLV-----RRKALY--NE--DWK---KAQLYP------
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--------------DW-RK------EQFQP-------------ALVT---L--K-HENFH
QNNS----------DP-----EEK------ENCS--KETHD-I------------SLSNK
--KGDGNLIIL-----------NQKSFT---SGRYF---WE-VD-TGDTD------EWAL
GIYEVHIS-D--N-EL--------------------------------------------
---------------PKDVPLKKFRVLE-K--K--------GCNYRALTCGPKVISQEVP
---------------------------------VLIEKFPQ---KIVIFLDYEDSDISFY
DMTEGTH--IFSFTQVSF-S-GSLYPYFK-------------------------------
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---------------------------------------------------MKRTIFSFF
---RGL------------------------TVST----SLPGY------VI--------F
FIALHIHR-------------------------------------------LAIAQ-FTV
--------T-GPD-HPITVPVGGEAVLPCHLSPRTSAQDM-ELRWFRLKF-S---A-VVH
QYAKGQDQYDG----QMLEYHGRTEL-LKDDITNGNV-SLRLRPVRPSDHGQYTCL--FQ
-S-R--VFYEEA-FLE------L--M-VS-----AIGSDP-----------------HI-
------SVDGHQDG-GI-R---V--VCHSTGWHPEPQAQWRDHHG-QHLPS-A-------
------S-------------------ED-ISKEANGLFHSQISIVIT-----E--DSNQ-
NLSC-SVRNPL-VNQ-EKIHM---V---PSLA-E--------------------------
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F---FPRV--S----------------P----WMV-ALWVS-LAV-----LI--------
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-------------------------------------------------------Q-FSV
--------V-GPR-AAIIASVGEEAVLPCHLSPETDAKDM-EVTWDRMDS-N---V---H
RYANSQE--VA----QSSQYQGRTEF-LKENINTGQV-ALRIHPILPSDGGEYRCF--FK
-L-----YESEA-QVE------V--L-VT-----ASGTTP-----------------QI-
------HIEPGGTG-EV-K---L--TCTSRGWYPEPEVQWRTYKD-CGI-W-T-------
------V-------------------ET-KTVAEDGLFQVQTSVTVD-----A--R-SR-
DVSC-AIRNPV-LSE-EKEA----H---ISMA-XXXXXXXXXXXX---------------
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-------------------------------------------XXXX-----X-XXXXXX
X-------------------------------------------------------XX--
------------XXX-XXXXX---------XXXXXXXXXXXXXX-XXX------------
--------------------X---------------------------------------
---------------X-----XXX---------XXXXXXXX-------------------
-----------------XXXXX-------------------------------------X
XXXXXXXXXXXXXXXX-XX------XXXXXWR-----KAQFKREDIT---L--D-EDTAH
PLLL----------VS-----RDRKYVIDVEE----K--QD-V------------PDN--
P---ERHSHVL-----------G---EN---SFWHY---WE-VD-V-------EVKTWEI
GLCST----Q--K-GD--------------------------------------------
---------------IYVCPKNGFWALS-L--E--------NNEYKALSTP-P-----SI
---------------------------------LNVPEPPI---VLGIFLQYEKGLISFY
NVTDCSF--LYTFKST-F-S-KPLKIS---TL-DLL-------LLEIC-Q----------
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------------------------PAVMTKT-CFQD-AFLPSC----FII---LIF--LQ
LLPTVVHG-------------------------------------------NGNVT-FDV
--------I-GPN-EPILAIVGKGADLPCHLSPNISAKDM-ELRWYRDKF-S---P-AVY
VYERGKNVSGE----QMEEYRGRTTF-LIDHIANGTA-AVRIHNVTVFDNGTYHCY--FQ
-E-G--TRHGEA-TLW------L--K-VV-----GLGSQP-----------------RI-
------RLRDDKEE-GV-Q---V--ECTSAGWYPQPQVEWRDFRG-KIIPS-V-------
------A-------------------NL-SVSPTSGLFAVVSNVVIT-----D--RAME-
GLYC-SIANPL-LFK-EKLT----V---SLVP-A--------------------------
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-----------------------------------------------------------S
F---SRSV--W----------------P--KVWRI-SLPLI-LMA-----LGLVVAGA--
I-----CISWKKLRDEAELKT--------GKWGSRKV-----------------------
---F--------------------------------------------------------
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------FNEVKVRCNR-G-------------------HKALRRGSLS---L--D-PDTAN
PKLE----------LS-----KDLKSVSRLLF----T--QD-L------------PDN--
PERFNKDPCVL-----------GQEQFT---RGKHY---WE-VE-V------GNRKAWNL
GVCLESLN-R--K-GR--------------------------------------------
---------------IPKSPKHGLWAVE-F--Y--------KEELWALTFP-R-----IH
---------------------------------LHPSQPLQ---RVGIFLDYEAGNISFY
NGADGSH--VYTFSGVSF-S-GPLRPFFCLWLYDRS-------PLTIC-SGS-RETGEVS
GPLQ----V------------------------SE--------LHQEASVTPV---IERA
AAFSKDREPPLKRP---MFSPQSSP-----------------------------------
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---------------------------MESA------AALHLS-----RPASLLLL---L
LLLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------SMRGHEDG-GI-R---L--ECISGGWYPKPLTVWRDPYG-GVVPALK-------
--------------------------EV-SMPDADGLFMVTTAVIIR-----D--KSVR-
NMSC-SINNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCAVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILMIP-----IAI--C
I-----YWINKLQKEKKI-LSG--------EKEFERETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEE----EL----------------------------------------
-QV---KGK----RGW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--CPFR-HLEES-V------------PDN--
PERFNSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KGQYRAVSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRLGCEDSP-------I-FIC-PAL-AGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---A-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDMSRGNM-ALVIHNVTAQENGIYHCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPTLK-------
--------------------------EV-SITDADGLFMVTSAVIIR-----D--KSVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SLAVI-LALFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------ELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
AERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVAIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-MPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGMQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPD-KPVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQF-S---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRI-SLRLENITVLDAGLYGCR--IS
SQ----SYYQKA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SITGYVDR-DI-Q---L--LCQSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNRDMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMRHAH-LSR-EVESR-------VQIG-DTFFEP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQWK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PKLC----------VS-----D-LKTVTHRKA----P--QE-V------------PHS--
EKRFT-RKSVV-----------ASQ SFQ---AG KHY---WE-VD-G------GHNKRWRV
GVCRDDVD-R--R-KEY-------------------------------------------
---------------VTLSPDHGYWVLRLN--G--------EHLYFTLNPR-F-----IS
---------------------------------VFPRTPPT---KIGVFLDYECGTISFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSYN-E---QNGTPIVIC-PVT-QESEKEA
SWQR---------------------------------------------------ASAIP
ETSNSESSSQATTP---FLPRGEM------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYQGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKDYEDG-GI-H---L--ECRSTGWYPQPKIQWSNDKR-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSETDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------SLGSLMQA-------PLPSS------VFFLAHFLL--
--FLHPAD------------------------------------------V---KD-IKV
--------I-GPG-ESIMALVGEEVEFSCHLSPYQNAEHM-EIRWFRSQA-S---N-VVY
LYQKRQKPHDL----QMVQFRNRTTF-DDHAIADGGV-VLHLHSVVPADEGQYGCR--FL
-S-S--EFSGEA-IWE------L--E-VA-----GLGSDP-----------------HV-
------SLEGFKEG-GI-Q---L--RCSSHGWYPKPKVQWGDHLG-HCLSP-E-------
------S-------------------EA-IIQDSRGLFSLETSVIIH-----G--RAHN-
NVSC-SIQNPL-LSQ-KKEFV-------IQIA-GQSVKEGA-------------------
---------GSECGCRVLGSQVRGEGHSS--ASPSTSFSRRRISFLVPRSTALEL-RGTL
YLCS-----WPSGDYS-----------------DFPRQRKIVLSWWSLGSKAPVGCFPDV
F---LPRT--S----------------P----WKK-AFLGT-LVA-LPLPLALLAALC--
L-----YHLHKQRSSQ--------------------------------------------
----------------------------------GE-----SDWR---RTEGQA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AATAH
PSLQ----------VS-----EDGKSVFA-----------P-A------------PHD--
PRRFSGQTCVL-----------SRER FS---AG RHY---WE-VH-V------GRRSRWFV
GACLASMA-R--P-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------GHEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RLGIFLDYEAGKLSFF
NASDGSH--IFTFTDTF--S-GALCAYFRPRAHDGS---GHPEPLTIC-SLW-ATGARVT
EEN------DSDTWLQ----------------------------PY-ELS----------
-----DPSPG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------PTVM------RSL----------GFHLLHLPVC
LALVQ-------------------------------------------LLTLCSAQ-FAV
--------I-GPP-EPILAMVGEVIELPCHLFPKMSAETM-ELMWVRSGL-R---Q-VVR
AYADGKEG--T----EIAEYQGRTSI-LREDIAEGKA-ALRIHKVRASDSGTYQCY--FQ
-D-A--KFYQKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EMKGYEDG-GI-R---V--ECTSAGWYPQPHVEWRGDGG-ESLPAM--------
--------------------------AA-GAADGEGLYAVTSSVILK-----G--GSGK-
GVSC-VVRNPL-LSQ-EKTAR-------VSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FSSP--K----------------P----WQV-AMGVT-LVA-----LLGILVGA--
V-----ISRGRQQKRIRAL---------IQEMERQQAEKEAALAERQ-------------
----------------RERS---------ALETLQE-E---LRWR---KQQYLP------
----------------------TGD-----------------------------------
------------------------------------------------------------
--------RSQ--------------------AYAEWKRALYQPADVI---L--D-PDTAH
PNLL----------IS-----EDKRRLTWAGI----R--KS-L------------PDN--
PKRFHYRSCVL-----------GCESFT---SGRHF---WE-VE-V------GDRKQWNL
GVCRENVE-R---KPP--------------------------------------------
---------------VKIAPQNGFWTIALL--D--------GHDLQARTDP-R-----SK
---------------------------------LTMANPPK---RVGVFLDYERGEVSFY
DAMDGSH--IYTFSQASF-S-GPLLPLFRILSEEPS-------ALTIC-PAL-RGVGSSL
----L--PD----------------------PLPD--------PSLETPVA------SGS
ADGIEDPQAEERSL---LLSAQP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MECT--GL---CFY--------GHC------IV
MFLLH--I------------------------------------------TPSSEK-FTV
--------T-GLE-GPVLAPLGGNLELSCQLLPPQHAEHM-EIRWFRDHY-T---Q-PVH
LYRDGKDIYGE----TISKYVERTEL-LKDAIREGRM-TLRIFNVTVDDDGPYHCV--FK
-D-S--NFYEEH-ITE------V--K-VT-----GSFYEF-----------------TF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLLL--LL
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-NPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRITF-VSKDIIKGSV-ALVIHNVTTQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISTGWYPEPLTVWRDPYG-EVVPTLK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KYVR-
NVSC-SINNTL-LGQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTA--S----------------P----WMV-PMAVI-LAVCIIF-----MAM--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PETAH
PELF----------LS-----EDRRSVRR--GPCR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRHSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPER------V
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-T-VPVRPFFRLGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------SEK-FTV
--------I-GPQ-QPIIALLGGEATFPCHLSPQMDAQNM-NVMWFYGQF-S---N-LVH
QYKNSQDNLKH----QRQEYKGRTEF-LRDDISNGSV-ALKLRHIRPSDEGKYQCS--FE
-S-P--HVYEKA-EFQ------V--Y-VA-----GKGSTP-----------------HI-
------HVENDGNK-GV-R---L--TCTSTGWYPEPKVQWRKNQE-KSLSQ-D-------
------T-------------------KI-M-KNENGLFFVETSIIVS-----T--DSTV-
NVSC-FIWNHL-LNQ-KLETN-------VSLS-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------ELVSGQ-WQV
--------T-GPG-KFVQALVGEDAVFSCSLFPETSAEAM-EVRFFRNQF-H---A-VVH
LYRDGEDWESK----QMPQYRGRTEF-VKDSIAGGRV-SLRLKNITPSDIGLYGCW--FS
SQ----IYDEEA-TWE------L--R-VA-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTAKWKGPQG-QDLSSDS-------
---------------------------R-ANADGYSLYDVEISIIVQ-----E--N-AG-
SILC-SIHLAE-QSH-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLLC---GALCGVVMGM--
-----IIVFFKSKGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PKLC----------VS-----D-LKTVTHRKA----P--QE-V------------PHS--
EKRFT-RKSVV-----------ASQG FQ---AG KHY---WE-VD-V------GQNVGWYV
GVCRDDVD-R--G-KNN-------------------------------------------
---------------VTLSPNNGYWVLRLT--T--------EHLYFTFNPH-F-----IS
---------------------------------LPPSTPPT---RVGVFLDYEGGTISFF
NTNDQSL--IYTLLTCQFEG-L-LRPYIQHAMYD-E---EKGTPIFIC-PVS-WG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKPA------ASLCFS-----LPAF-L-L----
-LLLSLFA-------------------------------------------LASAQ-FTV
--------V-GPA-DPILAMVGENITLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRERTTF-VSKDISRGSV-ALVIHNITAQENGIYRCY--FQ
-E-G--RSYDEA-ITR------L--M-VA-----GLGSNP-----------------LI-
------EMKGHEDG-GI-R---L--ECTSGGWYPEPLAIWKDPYG-EVVPSLE-------
--------------------------ET-YTADADGLFLVTVAVIIR-----D--DSVR-
NMSC-SVNNTL-LGQ-EKETV-------IFIP-ESFTP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILAI--Y----------------P----WLV-ALAVF-LAILTIL-----MSV--S
F-----YWIKKLQREKRI-LSG--------EKEFEQEEKKIA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QQLQEELQW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDQRSVRR--GPFR----QS-V------------PDN--
PERFSCRPCVL-----------GRES FV---TG KHY---WE-VE-V------EDVMVWTV
GICRDSVE-R--K-GE--------------------------------------------
---------------DLLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLRERLR---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPHIDF-S-GPLRPFFRLGSDDSP-------L-FIC-PAL-VGANGVT
VPE--------EGLILYREEIHHSAQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------KKMEGFPGFS-----PA--------SFLLPF----
-LLLQVPT---LCS--------------------------------------AGFG-FSV
--------K-ASA-EPVVVLLGEDAILPCQLYPAQSTAHM-HIRWYRAQL-S---P-AVL
VFQDRQDLGGE----QMLEYRGRAEL-LGASLGRGDA-TLQIRRARTSDHGQYRCR--VE
-D-G--DVFQEA-TVE------L--H-VI-----GLGSVP-----------------HI-
------YMMGPEEG-GI-R---V--LCSSGGWFPSPKVQWRDTAG-VKLPS-L-------
------P-------------------ES-QSQDGDGLFRVVASLVVK-----D--SSVG-
NVTC-SIQNLL-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--S----------------P----WKV-ALAGT-LPV-----IGILLSGL--
S-----YVGWKQHQAKKRAIK--------EKKKESQE-TDQMRSEKESV-LKDQ------
------------EK-----LEAELE-----RRKKLY--HE--DWK---KALIYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EYFKPE-IYNGDPLFSFLALVS---L--N-HEIFD
QNNS----------DP-----KRK------ENCN--EE---------------------I
--QGDGNLITL-----------EKKDFK---SGQYY---WE-VD-KMDTD------EWTL
GIYEEHEE-E--N-GL--------------------------------------------
---------------SKEA-SKKFRVLV-K--R--------GCEYRALAYCSQNIALEES
---------------------------------LLIKEHPQ---KIVIFLDYEDSNLSFY
DVASGAH--IFSFTQPSF-S-GSVNPYFKHKAIE--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MG
---S----I--------------GSGVMGAT--E----VLT--------SYC------VV
LCLLQ-MV------------------------------------------ALSSGH-FTV
--------I-GSQ-RPILATLGGNVELNCQLSPPQQAQHM-EIRWFRNRY-T---Q-PVH
LYRNGKNLHGE----TMSKYVERTEL-LTDAFNEGKV-ILRILNVTVDDGGAYHCV--FK
-D-G--EFYEEH-ITE------V--K-VT-----ATSSDI-----------------QI-
------LMHTPNIK-GV-M---L--ECHSGGWFPQPHMEWRNSKG-EVIQA-T-------
------S-------------------KF-HSQDKNKLFNMSMVLFIE-----A--SSHR-
NVIC-YFQNLV-THQ-EQSIN-------IVLS-GELFS-------WKIVWIMILSTISFV
MID-FCMTYCVQQ-QLIHEESL---S-------------TVDNDQCESDQ--SEG-----
-TCYKRNYPWIIIAVVPIIS---VFAIIGVMLFLHLE---------------QRVTILEQ
H---FELD--T--------------------LWL-EDISV-ILCV-VIV-SNINLI-P--
L-----IYFRLHEHV--------------PRFKD------------RSPIL---------
------------------------------N-----------------KAVV--------
--FLHFIYFSIVCGTIL-----LVHLQL------------RN-------KVSISDSLFSL
YNSWL-------------------------------------------------------
------------------------------------------------------------
----------------TDISMILGFLLSIFIV----T--TI-------------------
------AKSSL-------F-----------------------------------NKKWCI
GLCIHMKEAE-ATGGPCEGEEL--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLILL----
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAMVGENTMLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRRRTTF-VSKDISRGSV-ALIIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-ATPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SINDTL-LGQ-KKESV-------IFIP-ESFMP-------SMSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKEKKI-LSG--------EKESERKTREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KRQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-IGASGVT
VPE--------EGLILHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEHGCRP-------------SLLCSLPSL----
LLLAQLPT---WGS---------------------------------------ADE-FQV
--------I-GPS-EPIVAELGGDAILPCSLVPAMNAEDM-ELRWFRTKF-S---E-PVF
IYRNHQEQNRE----LMPQYAGRTSL-LRELLTQGQA-AVRIQNVQASDNGMYVCF--FK
-T-R--SYYEEA-TLE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGLEQD-GV-R---V--VCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGS-LTV-----LGLLLFGA--
G-----CFTRRELSAKLQERQ--------KQEKLRRA-KEEDQRAEEEA-LKAR------
------------DE-LQ----AELG-----QRKAAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ERFQAW-------------TVT---L--H-PGSAH
VNLL----------IS-----PEKKSVTWMY-SG--L-----------------------
--GWYHTCSVL-----------GLEGIT---SGRCY---WD-VE-IRCGA-FS---KWAV
GVCREHVQ-R--T-GT--------------------------------------------
---------------YTESPDKGFWVVG-W--Y--------HGSYFAWTKP-R-----KA
---------------------------------LSLRQHPC---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFPKASF-P-GALFPYFMLR-RN-V-------SLNIC-PTE-RGSEG--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------PEMAVSP
---N---------------------------------SCLP---------RGL-----LI
LTFFQLCK------------------------------------------PDS-AH-FDV
--------I-GPA-EPILAAVGDDVELPCHLSPNVSAERM-ELRWFRRKA-A---A-AVL
VRRDGREQAGE----QVPEYRGRATL-VDRDIAAGRV-AVRIHRVRASDDGEYRCF--FR
-Q-DG--SYEEA-SVH------L--K-VA-----ALGSDP-----------------HI-
------HMEVGESG-EV-R---L--ECTSVGWYPEPQVQWSTSEG-ETFPS-T-------
------S-------------------ES-RNPDEEGLFTVVASVIIR-----D--PSMK-
NISC-CIRNLL-LGQ-QREVD-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-LMV-----LGFLTVGS--
V-----VCTWRLYKERSRQRK--------DEFSSKAK--RGDYKALEAT-----------
----------------DTQYE----------EKLLE-EL---KWR---KATVRA----EG
LRVL--------------------------------------------------------
------------------------------------------------------------
-----------------------------SYL--EIKTQTHFCVDVT---L--D-PDTAH
PHLF----------LY-----EDSRSVRLEDS----R--QE-L------------PEK--
PERFDSWPCVL-----------GRETFT---SGQHF---WE-VE-V------GDRADWAV
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPH---RVGIFLDYESGDVSFY
NMTTGSH--IYTFSNASF-S-GPLRPFFCLWSYG-------KKPLTIC-PVA-DRPERVT
VVAD----A------------------------RD--------FTKEIPLS---PMGEFS
ASGDTDT---LHSK---LIPTQPSQR--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVNEM
---P----E--------------DRRVMEPA--FS---SLS--------GYF------VA
VLLLQ-IT------------------------------------------VLTSEQ-FTV
--------S-SSR-SHHVVMVGSQAELSCQLSPPQNAQLM-QVGWFRDRH-S---Q-MIY
LYEDGEEHSGE----GIQNYMNRTVF-LKDALEEGKI-TLQIYNVTVFDGGQYHCF--FK
-D-G--HTYEEG-IVD------L--R-VA-----AVGLDV-----------------QI-
------NVQVLDTE-GF-V---V--ECTSEGWFPQAQMAWRDSSG-NVIPH-L-------
------S-------------------KS-YSQDGAGLLRLKMTILLK-----N--STHG-
PVTC-CFYNPV-TGQ-EKRAG-------IVIS-DILFK---------SEYMSLMSHK---
-------ISY-PWIYLSIVVALLF---------------------------------LRI
-KVAQNIRCVHLVFQCLPFL---MY-IGILPIYFQF---------------RKRVSVSDD
L---FLLY--S--------------------IWT-EDLCI-ILGI-LML-FFTLLIFV--
L-----LYTLKGLTNCK-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------------Q-FRV
--------T-GPD-RPVTAPLGGEAVLPCHLFPRMSAENM-EVRWYRSLF-S---A-VVH
LYRDGQDQYGD----QIPEYRGRTEL-LKDDMASGRV-SLRIRDVRPSDDGKYNCL--FE
-S-Q--VFFEEA-LLE------L--Q-VA-----GLGSAP-----------------DI-
------SVEGRQDG-GI-R---V--VCRSSGWYPEPQVLWRDLQG-QPLPT-A-------
------S-------------------EK-ITPEAGGLFRAEIAMVIT-----E--ESNQ-
KVSC-CVRNPR-VNQ-ERES----A---IFIT-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---YPWF--S----------------P----WML-ALGGI-LGV-----MLGVLIAL--
A-----FWSRRQHRLKGKVTR--------REDAADRG-----------------RL----
-----HVQ--S-------------------D-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KLQAELRW-RR-----A-----QLCAVARSQGAGILDVT---L--D-PDTAH
ANLV----------LS-----ADGKTVTYEDR----Q--QD-R------------PDN--
PERFRTYPVVL-----------GASAFT---GGRFY---WE-VE-M--GD----KTNWTV
GVCREPVI-R--T-GK--------------------------------------------
---------------VKLTPGNGYWTVW-L--R--------NGKYEACTFP-P-----TP
---------------------------------LDLGVRPR---RVGIFLDYEAGEVSFY
SVTGGSH--LFTFTD-TF-S-GTLRPYFYIGYKEEG---KNAAPLVIC-PVP-GLWAGAE
KALE----Q------------------------EA--------------DGLWGKQGEED
RTDLGL------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAVT-CARD-VFQP--------------F--VT
LVFLQLPLASICHNCWTDPC-----------------------------ASGGKAN-FDV
--------I-GPQ-APILAMAGGQVELQCQLFPSVSAEDM-ELRWYRCQP-S---L-AVH
VRERGMDVDEE----QVPQYRGRTTF-VNDHVAAGKA-TVRIHSVTAFDNGTYCCR--FQ
-D-G--AEFGET-VVQ------V--Q-VA-----GLGTEP-----------------RI-
------QVMARQ-D-GV-R---A--ECTSAGWFPEPRVEWRDFRG-QARPA-V-------
------T-------------------NL-SASATTGLWAVASSLTLW-----D--RAVE-
GLSC-SISSPL-LPE-QRKVA-------E-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
-----------------------------------R-QKVS-T------IYHGSLI--SL
YLCFQMLI-------------------------------------------LVTGA-FQV
--------Q-GPH-EPMVAMLGGEAELSGILVPRQSIKHM-KISWTRTLP-S---Q-VVH
LYEDRQDKPEK----AMEEYLGRTQL-VKNFMYKGIV-ILRIHNVQPSDSGQYHCV--IQ
-H-G--SFHSEA-VIE------L--K-VA-----ALGSHP-----------------QI-
------HVEVIKSQ-QL-Q---L--ECKSEGWFPQPKVQWMDSEG-GEIPA-D-------
------S-------------------ET-HTQGKGGLFHVTTSLLLR-----E--ASQK-
NLTC-CVWNPV-LNQ-KKEEQ-------FSIA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
F---F-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVA
FFLVQ-------------------------------------------LHTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPKIQWSDAKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQVMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSDTDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
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-

-------------------------------------SRELPGYSLSGV---FASFFFML
LSMKQSDDFRVMGSVHP-ILDMVGEDALLTCQLLPKRTAMHMEVRWYCSEPRTPV-FLYR
DGDEVMEIQMEEYRGRVEWIED-GINEGSMALKIHSLWPSDHGQYWCRVKDDNYLAETSL
LLQVASLGSDPYIHMD---------GS---VE---------------------------S
GLQLVCTAKGWF----------PEPQ---FS---WQDIKGE-------------------
-----------KD--------------------------------G------------LF
YVESTLVVRDAS----------------------------------TEAVSCFIHN----
PSLAEKKG------------------------------SDV--SIPEK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCSLAPKTDAQSM-EVRWVRSHR-H---PGAVY
VYTDGARVAGE----QMAEYRGRTVL-LSDAISEGRL-TLQINDARTSDDGKYWCL--FE
-K---DGVYQEA-DLD------L--K-II-----GLGSSP-----------------QI-
------SMEGPKDG-KV-K---L--KCTSEGWFPQPQVQWRDTEG-NTIPSFS-------
--------------------------QD-LTQGSQGLFQVESFLLIT-----N--SSVV-
NVTC-SISSPL-LGE-EKKTT-------FYAS-GGW------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
---------------------------MEM-ASSA-----G-----CWLSGCLI-----P
LVFFRLPA-------------------------------------------HV-SG-L--
--------A-GDAGKFHVAPLGGRAELLCPLSLWPGMVPT-EVRWLRSPYPQ-RSQ-VVH
VFRDGKDRDED----SMPEYMGRTAL-VRDA-QEGSV-TLQILDVRLEDGGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSAGS
V---S-----P---------------------SA-VALAVI-LPV-----LVLLILVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QS-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---SGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYDAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEERI
VTKP---------------------------------------------------EGKG-
-YANGDMSLKVNSS---LLPRKAPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASAS-----G-----SWLPGCLI-----M
FVFLQLPT-------------------------------------------HGSXX-X--
----------XXXXXXXXXPLGGTARLPCPLYRWE-TVPT-EVRWLRSPHPQ-RSQ-VVH
VFRNGKDWDED----LMPEYKGRTAL-LRDA-QEGSV-TLEIRGVRLEDRGQYRCQ--VQ
-I-G--NLSRED-SVT------L-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------QV----
------------------------------------------------------------
-----------------------------------------------------AAPSSRS
L---S-----P---------------------SA-VALAVI-LPI-----LGLLIIVG--
I-----CLLWKQRRSKESLLYE--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAI---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFGDI--------------
------------------------------------F--QD-L------------PSC--
SKQFDNLDCVL-----------GQKIFF---KGRHY---WE-VS-V------KGKIKWTL
GVCTDSVC-R--W-GE--------------------------------------------
---------------LQISPEFGFWTLCLN----------RSNDYQALGNPRV------T
---------------------------------LYFEEFPE---IVGIFLGYEAGWVSFY
NVSNLSH--IYTYRKSF--R-GALRSFFYPG--PGG---QNRQPLT--------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADCS
---G-------------------FLGFLKQI-------PPCLS------IFF-T-YLL--
--FLQVWE------------------------------------------VN-SEE-VWV
--------L-GPE-ESILARVGEAVEFPCRLSSYQDAKHM-EIRWFRTQV-S---N-VVY
LHQEPQERSSP----QLAQFRNRTLF-EAYDIAEGSV-NLHILSVVPSDEGRYGCR--FL
-S-H--NFSGEA-MWE------L--E-VA-----GSGSDP-----------------HI-
------SLEGFNGE-GI-Q---L--QCSSSGWYPKPKVQWRGHQG-QCLSP-E-------
------S-------------------EA-ITQNAQGLFSLETSVIVR-----G--GAHS-
NVSC-IIQNPL-LSQ-KREFT-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRM--S----------------P----WKK-AFVGT-LVV-LPLSLMVLTMLA--
L-----RYFYKQRSFQEKRVK--------QGEK-VRE-----------------------
------------------KLQTEL----DWRRSEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----NNGKSVSSR---LGVP--ST-A------------AGD--
PQRFSEQTCVL-----------SRER FS---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--S-EP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------RCEYFVLDPH-R------V
--------------------------------ALALRVPPR---RIGVLLDYEAGKLSFF
NVSDGSH--IFTFTDTF--S-GALRAYLRPRAHDGS---EHPDPMTIC-SLP-VRGPQVL
EEN------DNDNWLQ----------------------------PY-ESL----------
-----DPAWADNEA---LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------APLHFS-----LPASLL------
-LLLSLFP-------------------------------------------PASAQ-FTV
--------V-GPA-DPILAMVGENITLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKDGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGIYRCY--FQ
-E-G--RFYDEA-ITR------L--M-VA-----GLGSKP-----------------LL-
------EMKGYEDG-GI-R---L--ECTSGGWYPKPLATWKTSYG-KAVPALE-------
--------------------------EV-NTAATDGLFLVTTAVIIR-----D--KFLR-
NMSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------SISPCIIILSF----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAILIII-----IFV--S
V-----YWIKKLQKEKKI-LSG--------EKEFEQERKDIALKDLE-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KEKE----L----------------------------------------
-QI----------KGW--------------------RRTLLHAADVV---L--D-PDTAH
PNLF----------LS-----EDRRSVSW--GSSQ----QS-V------------PDN--
PERFDCRPCVL-----------GRES FT---SG KHY---WE-VE-V------ENMMVWTV
GICRDNVE-R--K-GE--------------------------------------------
---------------GLLVPQNGFWTLEMS-----------ENQYWALSSPER------T
---------------------------------LLLTEPLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-GPLRPFFRLGSDDSP-------L-FIC-PAL-TGANGVT
VPE--------EGLTLHKAGTHHHS-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MRL---LG---NHRRE-A---IISLPGLT--LF
FVHLPIHT-------------------------------------------LESAQ-FTV
--------T-GPD-QPIIAIVGEDVVLSCHLSPTMSAEDM-EVRWYRSDF-S---S-PVH
LYRYGKDQYEQ----QMPEYTGRTDF-LRDGIRDGRV-ALMLRKVTPTDEGQYRCY--FQ
-S-T--AFYGDA-ILE------L--Q-VV-----ALGSAP-----------------LI-
------SVEDYQDG-GI-R---V--VCRSAGWYPKPQVFWQDLTG-RRVPS-L-------
------S-------------------ET-KSGRHYGLFEIEASVIVK-----E----TS-
NISC-SIRDAL-LKQ-EKKS----T---INIA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
I---FPKL--S----------------P----WIT-IPCTI-LVI-----EFFVICSL--
L-----YYFKTKEKRDEE----------------G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------RW-R-------------------NWLRKAEQLS---L--D-PHTAN
PFLL----------IS-----PDGKRVRLEVKGK--D--QE-E------------PGY--
SEGFSYSPCVL-----------ACQGFT---QGRHY---WG-VE-V--GS----KGGWAV
GVAKQSVR-T--KEGV--------------------------------------------
---------------VSLKPEDGVWVIERQ--W--------WGQFWALSNP-V-----TP
---------------------------------LSLSKKPE---KIRISLDYDMGLVEFF
DADDVIP--LYTFAPASFEG-ETIFPFFRVGGAG-A-------HLRLC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------SGTVP-----------------HI-
------HIEHGETK-GI-K---L--TCASTGWYPEPEVLWRDSKD-S--IP-A-------
------S-------------------ET-KTTEENGLFHVETSIIVD-----E--SSKG-
NVFC-VIRNPL-LHV-GMEA----H---ISIS-XXXXXXXXXXXX---------------
------------------------------------------------------------
-------------------------------------------XXXX-----X-XXXXXX
X-------------------------------------------------------XX--
------------XXX-XXXXX---------XXXXXXXXXXXXXX-XXX------------
--------------------X---------------------------------------
---------------X-----XXX---------XXXXXXXX-------------------
-----------------XXXXX-------------------------------------X
XXXXXXXXXXXXXXXX-XX------XXXXXWK-----KALLYPGPVT---L--D-PSSAH
SHLN----------VS-----QENRSLPGKLT--------D-N------------RSS--
----DDKYSAL-----------GLPGIT---SGQCY---WE-VE-E------MERKEWAL
GVCRKDVD-R--K-GW--------------------------------------------
---------------FRECPEKGFWVVG-I--A--------DKYC-ACTTQ-V-----TL
---------------------------------LPLRQCPQ---RVGVFLDYDAGDISFY
NMTDGSH--IFSFLQSSF-S-GTLFPYFVIRR-HL----------TIC-SMV-GGLRSS-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFR
---N---------------------------------SCLL---------RWL-----LT
FIPSQCPT-------------------------------------------LKSTH-FNV
--------I-GP--EPILALMGED-ELSCHLTPNMSAEHM-GLPWFTMFS-P---L-ALV
KPG--HEQAGG------QGGDRGATL-VKDHLSAGCM-SVRSHRVRTSDEGIYGCF--CR
-V-TP---CEDP-LID------L--K-VS-----ALGSDP-----------------HI-
------QVEVQESG-AI-R---L--ECSSAGWYPEPQVQWRTLQG-ENFPS-T-------
------T-------------------ES-SIPDEEGLFTVAASLMIS-----D--NTLG-
NVSC-CIRNLL-LGQ-EKEAD-------IPIP-ASL------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-MLI-----LGFFTIGS--
I-----CMTWRLYRERSRERK--------REFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----DDSKSVRLEDS----R--QN-L------------PEK--
PERFDAWPCVL-----------GREVFT---SGRHY---WE-VE-V------GNRTDWAI
GVCREDVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGAPH---RVGIFLDYESGEISFY
NMSDGSL--IYAFPKVPF-S-GPLRPFFCIWSCG-------KKPLTIC-PLA-ERLQGVS
VVAE----A------------------------QD--------LPKDIPLS---PIG---
---DTDT---LHSK---LIPTPAGQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------M-GPT-DPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRQRTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSSDEA-ILR------L--V-VA-----GLGSEP-----------------LV-
------EMRGHKDG-GI-L---L--ECISRGWYPKPLTVWRDPSG-EVVPALK-------
--------------------------ED-STPDTDSLFMVTTAVIIR-----D--RSVR-
NMSC-SVNNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPV----
------------------------------------------------------------
------------------------------------------------------------
----IV-------------------------------------LILMIP-----IAV--C
M-----YWINRLQKEKKIL-LG--------EKEFEREMREIAIKDLE-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KE----KEL----------------------------------------
-QI---KEQLQEELRW--------------------RRMFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVSR--GPFR----QS-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDISFY
NMKDRSH--IYTCPRSVF-S-VPMRPFFRLGSDDSP-------M-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHRSPQDQFPGLTAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LFVLCFLF-------------------------------------------HQTDK-LKV
--------T-GSI-HPTVAKRGEDVTLSCHLSPETYAKHM-KVRWFQVHF-F---H-PGH
MDVD---MNRK----PIA-EDKRIST-EPDAINKGIV-TLKIFHVDTSDNGQYWCR--FE
-Q-N--GLFQEA-SLE------L--K-VA-----GLGSSPQI------------------
------YLKGNKDG-RL-Q---L--VCTSEGWFPQPLMWWRVEGG-ENLSS---------
-----LS-------------------ED-RIQDINGLFHVETSVMIR-----N--DSMG-
DVIC-SIYNPL-LGQ-ELSA----S---YIPE-S--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---LGMI--P----------------S----WKT-LL-LT-LGL-----FLIVTIGG--
-------FIWHPGHKKGKNFF--------FLNKKTTELSS-------QSSQDDKDHK---
-SLQAEIDYSLQNKDLQLISN---------PECCLS--V--SSWS---KWEKF-------
---------------------KPAALV---------------------------------
------------------------------------------------------------
--------------------------------------------NCI---L--D-SKTAH
PELI----------IS-----EKGRYMTRGNM----R--QN-L------------PDN--
PQRFNFLPSVL-----------GQKKIT---SGKHY---WE-VE-V------GPGSGWFL
GICREDVN-R--K-RD--------------------------------------------
---------------TQVTPENGFWIIG-S--Y--------GNDYWAITSP-S-----TL
---------------------------------LSLRVSPH---KICVSLDYHRGQLSFK
NVTDGSH--IHTFHITSF-S-GTLRPFFLL------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------HFTV
--------V-AHA-EPLLAMVGEDAVLHCQLFPKKSAEQM-EVRWFRSQF-S---P-AVY
VYKDGKEREEE----QMREYQGRTTF-MRDNIRDGKV-ALKIHNVTAFENGRYHCY--FQ
-E---GRSYEEA-FID------L--K-VA-----SMGSDP-----------------FI-
------KITGYEYG-WI-Q---L--ECTSAGWYPQPWAEWRNLVE-ETIPSLE-------
--------------------------ES-LAPSEDGLFVVTLSVIIT-----D--HTVT-
SVFC-SIQNLL-LSQ-ELLTM-------MSIP-STWM-----------------------
------------------------------------------------------------
-----------------------------------------------------------V
V---------L---------------------TVTLPVLGL-FIAST-------------
I-----YFIWKQHRRKKTLFI--------E-QETECEEK---------------------
------------------------------EREKLKE-E--LRWK---RTQ---------
-LHA--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------X-XX---
XXXX----------XX-----XX-XXXXX-------------------------------
------------------------XX-----XXXXX---XX-XXXX---XXXXXXX----
------XX-X--X-XX--------------------------------------------
---------------XXXXXXXXXXXXXXX-----------XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXX
XXXXXXX--XXXXXXXXXXX-XXXRPFFRLGSDD-N-------PLVIC-PAF-TGAEGVT
VPESGLILY---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPN-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAGGRL-SLRLENITVLDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWFPRPMAKWKGPQG-QDLSADS-------
---------------------------R-TNMNMHGLFDVELSLTVQ-----E--N-AG-
SVSC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WYL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----H--QD-M------------PPS--
EKRFI-RKSVV-----------A SQNFQ---AG RHY---WE-VD-V------GHNQRWYV
GVCRDGVS-R--R-KKR-------------------------------------------
---------------VTLSPNHGYWVLGMN--A--------ENLYFTLNPH-F-----IS
---------------------------------LCPRTPLT---QIGVFLDYECGTVSFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSHN-E---QNGTPIVIC-PVT-QESERKV
SWQS---------------------------------------------------ASAIP
EASNSEFSSQATTP---FLPGSDA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------Y-WQK-----SKQNCIGA--
S-----FFLWRQQKEIIAL---------SRETEREQEMKERGYSATK-------------
----------------QEIS----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------LRADVI---L--D-PDTAN
PILL----------VS-----EDQRTVQRAEE----P--RD-M------------PDN--
PERFEWRYCVL-----------GCGS FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYQAL------------
---------------------------------------TE---KVGVFLDYETGDVSFY
NAVDGSH--IHTFLDICF-S-GPVYPVFRILTLEPT-------ALTIC-PVP-KGVERSL
D---P--DL----------------------VAPA--------HPLETLVA------PGL
ANESGEPQAEVTSL---LLPAQPGA-DSLPLH--------S-NQAEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------PN-SE--VKV
--------L-GPE-YTVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRNHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKF-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWK------L--E-VA-----G-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------KLTAELE-------------
------------------KLQKEL----DWRRTEGQ-----AEWR---AAQKYA----D-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------R------V
--------------------------------ALPLRVPPR---RLGVFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPT----------
-----DPAPD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVA
FFLVQ-------------------------------------------LHTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITVGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EAKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSDAKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNAV-LGL-EKTAS-------VSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSDTDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSS-----G-----AWLSGCLV-----A
LVFLCLPM-------------------------------------------RV-S-----
----------GDTGNFHLAPLGGTAELPCPLALWPVSVPT-AVTWLRSPHPD-RSQ-AVH
VFRDGKDREEG----VMPEYKGRTAM-RRDA-REGSV-SLEIRQVRLEDRGQYRCQ--VQ
-I-G--NLTREG-TVT------L--Q-VA-----VVGSDP-----------------YI-
------HVKGYDAG-WI-Q---L--VCRSAGWFPKPWAEWRDPQG-RVLLSLS-------
--------------------------EA-HSL-EAGLFRTAVSSRVR-----D--STLG-
NVSC-TFRNLA-LGQ-EKTAA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGK
I---S-----S---------------------SA-MALAVI-LPF-----LGLLIMAG--
V-----CLIWKQKRSKENLLYE--QVVEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KVL---------
------------------------------------------------------------
------------------------------------------------------------
-------KTLRNELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLM----------LS-----EDRRRVKLGER----K--QP-V------------PDG--
PQRFDFVVSVL-----------GAEY FT---AGC HY---WE-VF-V------GDKTKWAL
GVCSESVG-R--K-GK--------------------------------------------
---------------VTATPANGHWLVRQS----------SEKKYEALTSPQT------I
---------------------------------LRLKEPPR---CVGVFLDYEAGVISFY
NVTSRSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEPST
VPKP---------------------------------------------------EEKG-
-QANGDVAMKVDPS---LLPPQAPEP--SPLR---DMILPWPSDIGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------FPLCLV-----SEWR---AAQQYA----VG
RRQV--------------------------------------------------------
-------------------------------GP---------------------------
-----------GTLQG--------------------PDSEPLRSERD---P--G-FASAH
PSLE----------VS-----QDSRSLSSRG--AALF--PA-V------------PGD--
PQRFTKQMCVL-----------SHQRFR---TGLHY---WE-VD-M------GPSSRWFL
GACLEAVA-R--A-GP--------------------------------------------
---------------AHLSLAAGYWVMGLW--N--------SCEYFVLEPQ-R------R
--------------------------------ALSLRVPPQ---RVGIFLDCEAGKLAFF
NVSEGSH--IFTFTDTF--S-GPLCAYFRPRAPDGS---TRPDPLTIC-SLP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------I-GPT-EPVLAAVGNDAELPCRLSPNVSATHM-ELHWFREAP-S---W-ATL
LHRDPQGRAEE----PAPEFRGRVTL-EADSIRDPQ--------SPGCGRGDYRCL--FR
-D-DT--SSGEA-AVR------L--R-VA-----ALGSDP-----------------HI-
------SMEVQASG-EI-R---L--ECTSVGWYPEPQVQWKTPSE-AKFLS-T-------
------S-------------------ES-RSPDPEGLFTVVASMIIR-----D--MSLE-
NVSC-CIHNLL-LGQ-QKEAG-------ISMS-API------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WQV-AVAVI-LAV-----LGLLTTGS--
I-----VFIWRLYKDRFRERK--------SEFSSK-------------------------
-------------------------------EKLLE-EL---SK-------FYL------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MNVT---L--D-PDTAH
PHLF----------LY-----ADSKSVRLEDS----R--QK-L------------PDK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAV
GVCRENVI-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGSPR---RVGVFLDYDSGDVSFY
NMTNGSH--IYSFPSVSF-S-GPLRPFFCLWSCG-------KKPLTIC-SVA-DRPEKVT
VIAD----A------------------------QA--------LSKDIPLS---PTGEEP
ASGDADT---LHSK---LIPLQPCQK--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---N---------------------------------SHLL---------VGL-----LS
LMVLQLPR------------------------------------------LDS-AR-FDV
--------V-APQ-ESVLALVGGDAELPCRLSPNVSAEHL-ELWWFRQTA-R---P-MVL
LHRSEQGQEAE----PVAEYRGRTAL-LTAGLREGRA-ALHIRDVRASDDGAYLCL--CR
-D-NA--SSAQA-TVH------L--K-VA-----ALGSDP-----------------HI-
------RMEVQEDK-GI-R---L--ECTSSGWYPEPQVEWRTSSG-ERFPS-T-------
------S-------------------ES-RNPDEEGLFTVVASVTIR-----D--SSVG-
NVSC-GIENAL-LS Q-EKEVG-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FSK-L-T----------------V----WMV-AVLFL-AVA-----LGLLTIGS--
V-----LFTWRLYKERSRQRG--------AEFGSK-------------------------
-------------------------------ERLLE-E----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------LID VT---L--D-ADTAH
PYLF----------LY-----EDSKSVRLEDS----H--QT-Q------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAL
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNEYWALTPL-R-----TP
---------------------------------LPLAGAPR---RVGIFLDYESGDISFY
SMTDGSL--IYAFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-PAA-CGPEQVT
VITD----A------------------------QD--------LSKNIPLS---PLGKGF
TARDTET---LHSK---LIPSPASQA--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EKLRK--------QAEK-DKG---KQGPRRT---L---------
-----------------CPLPAAS----DWRRAEGQ-----AEVL---TLCLCT----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
RSLE----------VS-----QEGKSVWQESSCTAVP--GA-V------------VGD--
PQRFSEQTCVL-----------SCQRFS---AGRHY---WE-VH-V------GRRSRWFL
GVCLASAPQR--V-GP--------------------------------------------
---------------VHLSPANGYWVMGLW--N--------RCEYFILDPH-R------V
--------------------------------ALTLRVPPR---CVGIFLDWEAGKLSFF
NVSDGSH--IFTFTDTF--S-GTLCAYFRPRAHDGG---AHPDPLTIC-PLP-LRRTCIL
EEN------ELDAWLQ----------------------------PY-ESS----------
-----DPTLG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKGSPSVP-----PA--------GCLLPL----
--LLLMST---GVS-------------------------------------GEVSW-FSV
--------K-GPA-EPITVLLGTEATLPCQLSPEQSAARM-HIRWYRAQP-T---P-AVL
VFHNGQEQGEV----QMPEYRGRTQM-VRQAIDMGSV-ALQIQQVQASDDGLYHCQ--FT
-D-G--FTSQEV-SME------L--R-VI-----GLGSAP-----------------LV-
------HMTGPEND-GI-R---V--LCSSSGWFPKPKVQWRDTSG-NTLLS-S-------
------S-------------------EL-QTQDREGLFQVEVSLLVT-----D--RAIG-
NVIC-SIQNPM-YDQ-EKSKA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKT--C----------------P----WKV-ALVCS-VLI-----LLVLLGGI--
S-----LGIWKEHQVKRREIK--------KWSKEHEE-MLLLKKGTKSV-LKIR------
------------DD-----LQADLD-----RRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQE-------------APVR---I--N-YEMPD
QDKT----------DS-----RTE------ENRG--EE-----------------TVSSS
--QVDHNLITL-----------SQEGFM---LGRYY---WE-VD-VKDTE------EWTL
GVYELCTQ-D--A-S---------------------------------------------
----------------LTDPLRKFRVLE-K--N--------GDGYRALDFCSQNINSEEP
---------------------------------LQLKTRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFAQVPF-L-GSPYPYFTRNSMG-L-------SATAQ-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLILL----
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAMVGENTMLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRRRTTF-VSKDISRGIV-ALIIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--QCISRGWYPKPLTVWRDPYG-GIVPALK-------
--------------------------EV-FIPDTDGLFMVTTAVIIR-----D--KSVR-
NMSC-SISDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EKESERKTREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-Q-------IKGKRGW--------------------RRTVLHAGESQ---L--S-LASQL
TGLL----------RG--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------DEQGD-----------QGQYRALSSPDR------I
---------------------------------VPLKESLC---RVGVFLDYEAGDISFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDGSP-------I-FIC-PAL-TGASGIT
VPE--------EGLILHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FLGFLKQI-------PRCLS------IFF-T-YLL--
--FLQLWE------------------------------------------VN-SVK-VWV
--------L-GPE-ESILARVGEAVEFPCRLSSYQDAEHM-EIRWFWTHV-S---N-VVY
LYQEPQGRSSP----QMAQFRNRTLF-EAYDIAEGSV-NLHILNVLPSDEGRYGCR--FL
-S-H--NFSGEA-TWE------L--E-VA-----GSGSDP-----------------HI-
------SLQGFSGE-GI-Q---L--QCSSSGWYPKPKVQWRGHQG-QCLSP-E-------
------S-------------------EA-ITQNAQGLFSLETSVIVR-----G--GAHS-
NVSC-IIHNPL-LP Q-KKEFV-------IQIA-GLSMLIS--GI-EQLIWEQAKTQ----
---------CHQAGCRILEPGPILYLQFT--AFPSST---VVNSAIVPDPTWSEGCTAVF
MFCSYLAREAPIEDVT-----------------GHPKVQD--IMMWG----PRRSCFSDV
F---LPRM--S----------------P----WKK-AFVGT-LVV-LPLSLIVLTMLA--
L-----RYFYKQRSFQEKRVK--------LGEE-VR------------------------
----------------------------DWRRSEGQ-----AEWR---AAQQYA------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AH
PSLE----------VS-----NNGKSVSSR---LGVP--SI-A------------AGD--
PQRFSEQTCVL-----------SRER FS---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--S-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------RCEYFVLDPH-R------V
--------------------------------ALALRVPPR---RIGVLLDYEAGKLSFF
NVSDGSH--IFSFTDTF--S-GALRAYLRPRAHDGS---EHPDPMTIC-SLP-VRGPQVL
EEN------DNDNWLQ----------------------------PY-EPL----------
-----DSAWAVNEA---VW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------PN-SE--VKV
--------L-GPE-YTVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRNHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKF-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWK------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--S----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRGQEKLKK--------EAEK-REG---KLTAELE-------------
------------------KLQKEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------PSD--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGVFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPT----------
-----DPAPD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT--EV---LLV--------IHC------VV
LYLPQ-MV------------------------------------------ALSPEK-FTV
--------T-GLS-RPVLASLGGTLELSCQLSPPQQAQHM-EIRWFRNHY-T---Q-PVY
LYRDGKDLHGE----TTSKYVERTEL-LKDAIGEGKV-TLRIFNVTADDDGPYHCI--FK
-D-G--EFYEEH-ITE------V--K-VT-----VSSSDI-----------------QI-
------LMHSPNIK-GV-M---L--ECQSGGWFPQPHMEWRDSKG-EIIPA-T-------
------S-------------------KS-HSRDGNKLFNMTTTLFIK-----A--HSHR-
NVTC-YLQNHL-THQ-EESIS-------IVLS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSAF---AASFLFIV
FSMKQSDDFRVIGSVYP-VLAMVGEDALLTCQLLPKRTAEHMVVRWYRSGSSTPV-FASR
DGSEVTEMQMEEYRGRVEWIED-HLTEGKVALKIHNIRPSDGGQYWCQFQEENYYGETSL
LLK VAGLGSAPSIHLM---------GS---VE---------------------------S
ELQLVCTAKGWF----------PEPQ---VS---WQDITGEEL-----------------
-LTASEHHFQEED--------------------------------G------------LF
YVESMLVLRNTS----------------------------------AEIVSCFIRN----
PELSEKKG------------------------------SNI--SIPEK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIELTCYLSPETDAQGM-EVRWVQSHR-Y---P-AVY
VYMDGDHVAGE----QMAEYKGRTAL-VRDAINEGRL-TLKISNARTSDDGQYQCL--FE
-K---DGVYQEA-HLD------L--K-IV-----GLGSYP-----------------SV-
------SLEEQKDG-QI-K---L--KCTSEGWFPQPHVQWRDREG-RPRPSFS-------
--------------------------QE-VTQGSHGLFHVQAFLLAT-----D--ASVV-
NVTC-SISNPL-LGQEEKMTT-------FFLS-ESGM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------P---------------------WKILLVLGL------------LLVGT--
V-----GLIWWNSYRKVDKTL--------D-PNTAHPDR---------------------
---------------------------------ILSE-G--NGLP---IMK---------
-PAR--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------R-RK---
EGLL----------KT-----PQ-SSKLQ-------------------------------
------------------------KG-----LNSGG---WY-TEVV---FGDRKIC----
------VQ------NV--------------------------------------------
---------------AKDSSSKSLLCVT--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAGGRL-SLRLENITVLDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTVKWKGPQG-QHLSSDS-------
---------------------------R-ANADGHNMYDVETSIIVQ-----E--N-AG-
SISC-SIHLAE-QSH-EVESK-------VLIR-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLLC---GGLCVVVMGM--
-----TVVFFKSKGK----IQ--------AEL----------------------------
------------------------------------------DLV---KIHK--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELREARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKG----P--QK-V------------PYS--
TKRFT-RKSVV-----------ASQG FQ---AG KHY---WE-VD-V------GQHVGWCV
GVCQDDTD-R--R-KDS-------------------------------------------
---------------VTLSPNNGYWVFGLT--T--------EYLYFTFNPH-F-----IN
---------------------------------LSLETPPT---RVGVFLDYEGGNISFF
NTNDQSR--IC-ILTCQFQG-L-LRPYIQHVIYE-E---ENRTPIFIC-PVS-WDQREKT
LLKG--------------------------------------------P------HTADP
DTAKGECAPQAAPA---SSPKPVHRKSRLPLS--FR-VLRF-FSPKPG----SSSSFQMR
E-----------------------------------------------------------
---DWPVPVGVRSHGCPEVGME--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKPE--LS---HFS--------GFC------VY
FLFLQ--V------------------------------------------MVSSEK-LRV
--------T-TPT-RYLLARVGGQAVLSCXVIPPHSVMHM-EVRWFRSGH-S---Q-PVY
LYRGGHKMSEE----AAPEYANRTEF-VKEAIGEGKV-SLRIHNINILDDGPYQCS--FN
-G-S--GFIDVA-IMN------L--N-VT-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------DELFN-------QDYIWVGIFPFSVGS
L-IFFGVLPLINCFFRSRGCAS-----------------------------------GCL
SKYLHVVTSWPVQIVH--FL---VCSGVLFAVYLPHR---------------HRGKWNQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFL
---N---------------------------------SCLC---------RRL-----LF
LLLLQLPK------------------------------------------LHS-AP-FDV
--------I-GSP-ESILAMVGEDAELPCHLSPNVSAEHL-ELRWFRR------------
--WDGREQEGE----QLPEYQGRVTK-VKDK-AAGRF-AVRIHGVRVSDDGEYRCF--FG
-E-DR--HYEKA-FVH------L--K-VA-----ALGSAP-----------------HI-
------NMEIQESG-EI-R---L--DCTSVGWYPEPQVHWRTSMG-EKFPS-I-------
------L-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVE-
NVSC-CIQNLL-LGQ-EKEVG-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----FSR-L-T----------------P----WMV-AMAVI-LVV-----LGLLTIGS--
I-----FFTWRLYKERSREKK--------NEFSPK-------------------------
-------------------------------EKLLK-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-Q------------SEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSH--IYTFPKDSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DEPEEVI
VIAN----A------------------------KD--------LTKEIPLS---PIGEDS
ASGDTDT---LHSK---LIPTQSSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA--FS---YVT--------G--YS----VA
ILLQM---------------------------------------------VVLPSV-LRI
--------K-NKT-SHMFKKIGGHAELSCQLSPPQSAEHM-QVGWFQEYY-S---Q-LVY
LYKDREEVSGK----STYNYVNRTVL-LKDTLGEGRV-TLRIHNVSVLDGGQYHSF--FK
-D-G--DTSEEA-IMD------L--R-VA-----ALGLDI-----------------QI-
------NVQIPDAK-GL-M---L--ECNSGGWFPSPQVEWRDSRG-NVIPH-S-------
------S-------------------KS-SSVDGAGLLHLKMSVLLK-----N--STHS-
PVTC-CVCNPV-TGQ-EKRAG-------VILP-GEVLS-------FSANYHFVGSINFRP
LSIYKVIVTR-PLLFLDLFPRLIM---------------------------------CCI
VQSINRIRSWGLVSLIYSIV---LA-SALFTIYLEKN----------P--PSFPVSDSDD
L---FPLY--S--------------------TWI-RDICV-ILTV-LMI-FFPVLISC--
L-----L-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSS-----G-----SWLPSCLL-----A
LAFLLLPA-------------------------------------------TV-SG-C--
--------T-GLTGDLHLAPLGGTAKLLCPLALWPVTVPT-MVRWLRSPHPD-GSQ-LVH
VFRDGRDQEEG----VTPEFKGRTAL-LRDP-QEGSI-TLEIRHVRLEDRGPYRCQ--VQ
-V-G--NVTRDG-SVT------L--Q-V--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------SA-VALAVI-LPV-----LGLLIMMG--
I-----YLIWKQRRSKEKLLYE--QVMEVE-NLLSDHAKEK-GN----------------
---------------------------------YMY------------RIK---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRSAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDQRGVKLGDK----R--QP-V------------PDG--
PQRFDFVVSVL-----------GAEY FT---A GCHY---WE-VD-V------GNKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTATPANGHWLVRQS----------SENTYEALTSPQT------P
---------------------------------LRLKEPPR---CVGIFLDYEAGVISFY
DVTNRSH--IFTFTHTF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEPPT
GPKP---------------------------------------------------EEKV-
-HANGDVAMTVDPS---LLPPRAPE-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------IEHNCP-FLI
--------N-VYTTSVKWDPNWNVLCSICQLSPPQSAQHM-EIRWFRNRY-T---Q-PIY
LYKAGKDLYGE----TTSRYVERTEL-LKDAIGEGKV-TLRIFNVSVDDDGQYHCF--FR
-D-G--DFSEED-IIE------V--K-VT---------DI-----------------QI-
------FVHPPNTK-GL-I---M--ECHSGGWFPQPQMDWRDSRG-DILLP-T-------
------S-------------------KS-HSQDGDKLFNMKMTLLLR-----D--AHSG-
NVAC-YLRNPL-TGQ-EERTS-------IVLA-ETFTC-------FLHLVSKALV-----
SLG-FI------------------------------------------------------
H----------HFALIIISS---VVVDVVLSVCLYQR---------------QRVPDSDP
L---FALD--A--------------------IWA-EDMIV-FLWV-LMV-FITMLI-S--
L-----IYFKMR------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSRP-HCGD-ASLPSC----LVT---FVF--LQ
FLPAG----------------------------------------------NGKAD-FRV
--------L-GPP-DPLLALVGQDKELPCKLSPNISAEGM-ELRWYRDQP-S---P-AVH
VYRNGKDVWEE----QMEAYRGRTTL-TTDHVARGEA-AVRIHNVTLFDNGTYHCI--FK
-E-H--TSYSQA-TLW------L--R-VA-----GLGSAP-----------------RI-
------HVIETQDN-GI-Q---G--ECTSAGWFPEPKVEWQDLRG-RKVPA-V-------
------T-------------------HF-SASA-TGLLAVTSTVAPQ-----D--GAVE-
GLTC-SISNPL-LPG-RKVA----K---SHLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---SERS--L----------------S--MERGP-VLPLI-LIA-----LGLVTAAI--
A-----CVFGKRQRDQHKSSP--------EGEAER-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GG-S-------------------EQSELAVSLS---L--D-PDTAS
PKLL----------VS-----EDQKSVKRLLF----D--QD-L------------LPN--
SRRFERDPCVL-----------AQER FW---SG RHY---WE-VE-V------GDRRAWIL
GVCLESLG-R--E-ER--------------------------------------------
---------------IPKSPQHGLWAVE-L--Y--------KKKLRALSYP-R-----TR
---------------------------------LSPLQPLR---RVGIFLDCEAGEISFH
NITNGSL--VYTFSGLSF-P-GPLQPFFCLWTHDPN-------PLTIC-SVV-TETQEDT
VSSG----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------PSL----------DFRLPHLLVC
IILVQ-------------------------------------------LLTSCSAQ-FAV
--------I-GPP-GPILAMVGEDTELPCHLFPKMSAENM-ELTWVRSSL-R---Q-VVF
MYAQGKEVEDR----QTAEYRGRTEI-LRDGITAGKA-ALQIHSVRASDSGNYLCY--FQ
-D-G--NFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EMKGHEDG-GI-H---L--GCTSTGWYPQPQIQWRDAKG-QNMPAV--------
--------------------------ATPPATDGAGLYAVTSSLTVK-----S--SSGE-
GVSC-IIRNPL-LNQ-EKTAQ-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRRA--Q----------------L----WIA-VFAGT-LPV-----CLLLLAGA--
G-----YFLWLQRKEKEAL---------FMEKERAEEEKETARAEKE-------------
----------------QEQR---------IKETLEY-E---LKWR---KIQYMA------
----------------------RGKKS---------------------------------
------------------------------------------------------------
----------Q--------------------AYPGE------------------------
------------------------------------------------------------
PG----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVT---------------------------------------TKG-FWV
--------F-GPS-DPVVAAPGREAILPCSVFPAMSVENMEELRWFRNRF-S---Q-AVF
VYRDQEEQKEE----QMIEYSWRTSL-VKDQFHEGKA-AVRIQNVQESDSGIYVCH--FK
-H-G--HFREEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSRG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTENSLVVR-----D--SSVR-
NVTC-STFNPI-LGQ-EKAMA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKT-AFVVI-LTM-----MGLLVLGT--
I-----SLFGWERFVRLKLQK--------EQIHIHCE-KDKAQTEKEDA-L---------
------------RT--AKWGYCEWV-----LTRVCS--F--TAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQTW-------------TFT---L--D-PASAH
PTLV----------IS-----QDRMRVTRKDTTV--C-----------------------
---LDDLFSVL-----------GTKGIS---SGRYY---WE-VK-LANGE-GS---KWIL
GVCREGVE-R--K-GF--------------------------------------------
---------------YFESPEKGFWTVG-Q--S--------SSGYWAYVDSGR-----DS
---------------------------------LSIRQAPQ---SVGVFVDYDERNISFY
NMSDKSH--LFSFHEASF-S-GTLLPYFQLKSGN-V-------SMTVS-SMA-CVSEGQE
GEEG----EKGEEQEEGK------------------------------------------
--------EEEESQ---FLQRVRDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
------------------------------------------EWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCKENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNISF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDC
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---V-------------------SLDSLKPA-------SLTRS------LVFLMHSSS--
---FSPGA------------------------------------------EL-SPS-IH-
-----------------PALVGE---------------RS-ARSWSTPQT--------SM
HCTEQQELPGR----ADGGVANRTKF-VKV-HRYGSL-ILQLTASSPSTRHIMLP---LL
-S-------NNS-LAN------S--L-EL-----RLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLSP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--S----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRCQETRGL--------SVSG-RRR---TG------------------
-----------------------P---------DRP-----GRAL---TLRLCA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------PSD--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGVFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPT----------
-----DPAPD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYNLSGV---IASFLFIL
LTMKQSDDFRVIGPAHP-ILARVGEDVLLTCQLLPKRTAMHMEVRWYRSEPSTPV-FMYR
DGVEVTEMQMEEYKGRVEWIED-GIAEGSVALKIYNIQPSDNGQYWCHFQDGNSCGETNL
LLKVAGLGSAPNIHME---------GS---GE---------------------------S
GVQLVCTTRGWF----------PEPQ---VY---WEDIQGEKL-----------------
-LAMSEHHIQDED--------------------------------G------------LF
YVETTLVVKNAS----------------------------------AESVSCFIYN----
PVLSEEKE------------------------------AVI--SIPEK-LQAELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCYLSPKANAWSM-EVRWVRSHR-Y---P-AVH
VYKDGDHVAGE----QMAEYRGRTVL-VSDTIDEGRL-TLQILSARPSDDGRYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGRKDG-EM-Q---L--MCSSDGWFPQPHVEWRDMQG-KTIPSSS-------
--------------------------EA-LTQGSHGLFHVETLLWVT-----N--NSTV-
NVTC-SISIPF-LGE-EKRAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------WKTLLILGL-LLAVA-------------
V-----GLLRRRS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLIL-----
LLLLRLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GIVPALK-------
--------------------------EV-VTPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SINDTL-LSQ-KKESV-------IFIP-ESFMP-------SMSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EKEFVVETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KG----KRGW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-EE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDRP-------I-FIC-PAL-IGANGIT
VPE--------EGLTLHRVRTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDISWYNLTAA---AIASVFLF
F------NFRVIGPDHP-ILVNVGEDALLTCQLLSKKNAMNMEVTWYRSEPNTPM-FAYR
DGAEVTEMQMGEYRGRVQWIRQNGTGKGHVALKMYKIQPSDDGKYWCRFQEGNYQGEASL
QLQVLGVGSSPNVHMQ---------GC---VE---------------------------N
DLQLLCTSKGWF----------PEPE---VN---WKSNTGEQL-----------------
-PTFSKHHLLDED--------------------------------G------------LF
YVESTLVVKNAS----------------------------------LENVSCFIHS----
HELNE-KS------------------------------STI--SISEK-TQTELAS-LKV
--------I-GSS-QPILVRVGEDIQLTCHLSPKTSAEDM-EVRWVRSHY-Y---P-AIY
VYVDGDHMSEK----LMEEYRGRTAL-ESDALNEGRV-TLQIRSARISDAGQYWCL--FE
-K---DGVYQET-SLD------L--K-VA-----GLGTFP-----------------LI-
------TMERPKEG-EI-L---L--TCTSEGWFPQPYVQWKDMEG-HSLPSYS-------
--------------------------EE-LYEDSHGLFQVKTL--LK-----N--DSDV-
NVTC-SISNTL-LDK-EKMVY-------FYTS-GQW------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPT------TSLRSC-----PLASLLF-----
FLVLSLFV-------------------------------------------LVSAQ-FTV
--------I-GPA-EPILAMVGENTTLHCHLSPERNAEEM-EVRWFRWRF-F---P-AVL
VYRGHQERPEE----QMVAYRGRTTF-MSTDISKGRV-ALIIHNVTAYDNGIYCCY--FQ
-E-G--RSYDQA-TMK------L--M-VA-----SLGSEP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYD-EVVPALE-------
--------------------------EE-YTADREGLFTVTMTIIIR-----D--CSVR-
NMTC-SVNNTL-LSQ-EVESV-------ILIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AVAVA-LPVVMLILL---TSG--S
I-----CLVKKHRRKKSI-LS---------------AEKEAEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----EAARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVIR--GSSR----QS-V------------PDN--
PERFDCRPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RIAVFLDCEGGDISFY
NMRDRSH--IYTCPPVTF-T-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLFLYKTRPISQSLVRKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
TLKLLKKH-V---------VAWE--------------------------------MRVMP
HSRK-------------------MSVHMERP-SGS-----G-----SLLVGCLF-----T
IAVFRSPA-------------------------------------------QV-------
--------S-GDAGKVYIAPLRGTAKLPCPLFLWPNMVLR-EMRWYRPGHLPRT-Q-AVH
VFQDGQDRDED----LMPEYKGRTAL-VRDA-HKGSY-TLQISNVRLEDRGLYQCQ--VW
-V-G--NSSRED-NVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-E---L--LCQSVGWFPKPWTEWRDTTG-RALLSLS-------
--------------------------EV-HSLDENGLFRTAVSSRIR-----D--NALG-
NVSC-TVRNEA-LGQ-EKTTA--------------------------------MII----
------------------------------------------------------------
-----------------------------------------------------GAPERGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLLILLG--
I-----WLICKQKKSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PERFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGIFLDYEAGIIAFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---KNTAPLIIC-TEL-QKSEESI
VPKQ---------------------------------------------------EGKD-
-RANGDVSLKVNPS---LLSPQGSEL--FLLN---DT---WPSNLGPALKGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVPT
------------------------------N------SCLL---------VCL-----LT
LTVLQLPT------------------------------------------LDSAAP-FDV
--------T-VPQ-EPVLALVGSDAELTCGFSPNASSEYM-ELLWFRQTR-S---P-AVL
LYRDGQEQEGQ----QMTEYRGRATL-ATAGLLDGRA-TLLIRGVRISDQGEYRCL--FK
-D-ND--DFEEA-AVH------L--K-VA-----AVGSDP-----------------QI-
------SMTVQENG-EM-E---L--ECTSSGWYPEPQVQWRTANR-EMLPS-T-------
------S-------------------ES-KKHNEEGLFTVAVSMMIR-----D--SSIK-
NMSC-CIQNIL-LGQ-GKEVE-------ISLP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAII-LLA-----LGFLTIGS--
I-----FFTWKLYKERSSLRK--------KEFGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYDAGDISFY
NMSDGSL--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-PTA-NGPEKVT
VIAN----V------------------------QD-----------DIPLS---PLGEGS
ASGDRDT---LHSK---LIPFSPSQA--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MLDFSQYSLSGA---VASFFFIL
LTLKPPDDFRVTGPSHA-IVAMVGEEALLTCQRLPKKTAVHTEVRWYHSEPSAPV-IAYR
DGGGMTEVQKEEYQGRVEWIED-GIAEGRVALKIHSIQASDNGQYWCRFQEGNYY SETSL
LLKVAGLGSAPRIHME---------WP---VG---------------------------G
G VQLVCTAKGWF----------PEPQ---VR---WEDGQGEQL-----------------
-LSVSEHHIQDEH--------------------------------G------------LF
YVEATLVVRDAS----------------------------------AETVSCLIHN----
PVLIQDKV------------------------------SVI--ALSEK-LQSEMAS-LTV
--------I-GPF-QPILVRVGEDVELTCYLSPKVNAQNM-EVRWVRSHR-Y---P-AVH
VYVDGDHVAGE----QMVEYRGRTAL-VGDAIHEGRL-TLQIHGARTSDDGQYRCL--FE
-I---DDVYQEA-SMD------L--K-VV-----GVGSSP-----------------LI-
------TMEGLKDG-DM-Q---L--MCTSDGWFPQPLVQWMDRQG-EAMPSFS-------
--------------------------EA-LSQDSRGLFHVETALLVT-----R--SSIV-
NVTC-SISNPL-LGE-RKTAS-------FSFS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MGLSAFL
---ENCVSL-KI----------PLGWTWKNRHKLF-----LLF---LVS-CLF-------
-VLTQLLS---WVT---------------------------------------TKE-FLV
--------F-SPS-DPIVAVPGGEAILPCSVFPAMNVENMEELRWFRSRF-S---A-AVL
VYRDQEEQKRE----QMPGYSRRTSL-VKDKFHQGKA-AVRIQNVQASDSGIYICH--FK
-Q-G--VFYEEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------RIKGPEDG-GV-S---V--VCMTSGWYPKPQVHWRDFRG-ENLTA-S-------
------S-------------------EI-HREDAQGLFRTETSLVVR-----D--SSVR-
SVTC-SIFNPI-LGQ-EKAMT-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFFVT-LTM-----MGLLVLGM--
G-----IVSETPHMICI-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SLMDW-RK------EHFQAW-------------TFT---L--D-PASAH
ANLA----------IS-----QDRLSVTRKDSTL--C-----------------------
---LEDLSSRV-----------RHRRH--------V---F--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------LEM-ASFS-----G-----SWLSGCLI-----T
LIFLQLPA-------------------------------------------PG-------
--------S-GDARKFHLVPLGGTAELLCPLPLWPGMEPT-EVRWLRSPHPQ-LSQ-AVH
VFRNGKDWDDG----QMPEYKGRTVL-VRDT-QEGNV-TLKILNVRLEDQGQYRCQ--IQ
-I-G--NLSKEG-SVT------L--Q-VA-----VLGSDP-----------------DI-
------HVEGYDAG-WI-K---V--VCRSVGWFPKPSAEWRDPQG-TVLPSLS-------
--------------------------EV-HDLDEAGLFQTTVSSRVR-----D--STLG-
NVFC-IIHNSA-LGL-EKKAV--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------PT-VALVVM-LPV-----LGLLFIAG--
I-----FLIRKQRRSKEKLLYE--QAMEVE-NLLSDHAEEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRAQLHFVAVT---L--D-PDTAH
PKLI----------LS-----GDRRCVRLGDR----K--QP-V------------PDN--
PQRFDFVVSVL-----------GSECFT---AGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPSNGHWLVRQS----------RENHYEALTSPQT------S
---------------------------------FRLKEPPL---YVGIFLDYEAGIISFF
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNLAPLVIC-SEL-HRSEEST
VPRP---------------------------------------------------ERKS-
-HANGDVSLKVDPS---LFPPPSEEL--FPLK---D--------LSPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENHHKPS-----LLF---NVS-CLF-------
-VLTQLLS---WVT---------------------------------------TKE-FLV
--------F-GPS-DPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRF-S---E-AVL
VYRDQEEQKRE----QMLEYSQRTSL-VKDQFHQGTA-AVRIQNVRASDSGLYICH--FK
-Q-G--VFYEEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------HIKGPEDG-GV-C---V--VCITSGWYPEPQVHWKDSRG-EKLTA-S-------
------L-------------------EI-HSEDAQRRFSTETLLVVR-----D--SSVR-
NVTC-STFNPI-LGQ-EKATA-------MFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFLVT-LTM-----MGLLVLGT--
S-----YLLRRERSARLKVQQ--------ETVNFQHE-MDESL--K--------------
------------------------T-----KEDALR--T--ATWK---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFRAW-------------TFT---L--D-PASAH
ANLA----------IS-----QDRLSVTRKDFTM--C-----------------------
---LEDLSSVL-----------GSRGIS---SGRHY---WE-VK-LTNGE-GS---KWIL
GVCREGVD-R--K-DF--------------------------------------------
---------------YFETPGKGFWTVG-Q--S--------SRGYWAYTDSGR-----DS
---------------------------------LSVRQAPK---TVGVFVDYTKGDISFY
NMSDNSH--MVSFKEDSF-Y-GTLFPYFRLRTGN-V-------SMIIN-SMT-CLSEGEE
GEEG----RRGRKRSKKG---KREKRGKKLFCFL--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EVRWVRSHR-Y---P-AVH
VHVDGDPVPGE----QMAEYRGRTTL-VSDAIDEGRL-TLQIRSARPSDDGQYRCI--FE
-K-D--GVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TMEATKAG-ET-Q---L--TCSSDGWFPRPHVQWRDTEG-KTMPP-S-------
------S-------------------EN-LTQGSHGLFHVETFLLVT-----N--ITAG-
NVTC-SISSPL-LSE-EKTAT-------FSLS-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------W
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVT---------------------PGLPARLLAL
ALLQLHALRAGQCPSCAPSCPVGWKRSDKSKCLPCVPAGDLLLPESRGSP--GLSRKGLG
---E---------------------------------GPTP---------AGS-----LA
CAHPDPPL------------------------------------------ARPPAR-FDV
--------I-GPM-EPVLVAVGKDAELPCRLSPNVSAEHM-ELRWFREAP-S---P-AVL
LHRDPQGRASE----PAPEFRGRVTL-VADGMAQGRA-AARIHAVRAADDGDYGCL--FR
-D-GA--SSGEA-AVH------L--R-VA-----ALGSDP-----------------HI-
------SMEVQDSG-EI-R---L--ECTSVGWYPEPQVQWRTPTG-EKFLS-T-------
------S-------------------ES-RSPDQEGLFTVATSVIIR-----D--TSLE-
TVSC-CIRNLL-LGQ-QKEVG-------ISTS-API------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WQV-AVAVI-LIV-----LGLLTIGS--
I-----VFIWRLYKDRFREKK--------SEFSSK-------------------------
-------------------------------EKLLE-EL---------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MNVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
AERFDSWPCVL-----------GREA FT---SG KHY---WE-VE-V------GDRTDWAV
GVCRENVI-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGSPR---RVGIFLDYDSGDISFY
NMTNGSH--IYTFPSVSF-S-GPLRPFFCLWSCG-------KKPLTIC-SVA-DGPEEIT
VTAG----A------------------------QA--------LSKDIPLS---PMGEEP
ASGDADT---LHSK---LIQRVP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---N---------------------------------PCLL---------ECL-----LT
LMVLQLPT------------------------------------------LDS-AP-FDV
--------T-APQ-EPVLALVGSDAELTCRFSPNASSEPM-ELRWFRQTR-S---P-AVL
LYRAGQEQEDQ----QMAEYRGRATL-VTDGLPEGRA-TLRIRGVRVSDQGEYRCF--FR
-D-ND--SSEEA-AAH------L--K-VA-----ALGSDP-----------------HI-
------SVGVKENG-QI-Q---L--KCTSSGWFPEPEVQWRTPSG-DRIPV-T-------
------A-------------------ES-GNRDEEGLFTVAASVIIT-----D--SSIM-
NASC-CIQNLL-LGQ-EKEVE-------ISVP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAIV-ILA-----LGFLTIAS--
I-----FFTWRLYKERARERK--------SEFGSK-------------------------
-------------------------------ERLLE-EL---S-------KLS-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SFDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCREDVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYESGDISFY
NMSDGSL--IYTFPSTSF-S-GPLRPFFCLWSCG-------KKPLTIC-PAA-NGPEKIT
VTAE----V------------------------QD-----------TIPLS---PLGEGP
ASGEADT---LRSK---LIPFSPSQA--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MP
---LS-------------------LDSFWKM-------PLPSR------FFFLKLLFS--
FLLLQLGE------------------------------------------PN-SED-LRV
--------V-GPG-ESILAHVGDEVEFSCHLSPYQDAEDM-EILWFRRQD-S---E-VVH
LYQERQELLHQ----QLGQFRNRTKL-FRDDITDGSV-ILHLQGVLPADEGPYGCR--FL
-S-S--HFSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--KCSSTGWYPKPQIHWRNHRG-QCLPP-E-------
------T-------------------EA-IIEDAQGLFSLETSVVVY-----R--GAHN-
NVSC-SIHNPL-LVQ-KKEFV-------VQIA-XXXXXXXXXXXXXXXXXXXXXX-----
----------------------XXXXXXXXX-------XXXXXXXXXXX-X---------
------------X------------------------------X----------------
-------------------------------------------------XXXXXXXXX--
X-----XX--XXXXXXX-XXX--------XXX----------------------------
-----------------------------XX----X-----XXWR---AARQHA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-SATAH
PSLE----------VS-----GDGKRVSQSRR---RPP-------------------G--
HTCSSEHKCAL-----------SREHFS---AGRQY---WE-VH-V------GSRSCWFV
GACLARAT-QGPG-RS--------------------------------------------
---------------GRLSPASGFWVMGLW--N--------NREYFVLDTH-R------V
--------------------------------ALSPRVPPR---RLGLLLDCDAGALTFF
NVTDRSH--IFTFHDTF--P-GPLCAYFRPRAQDAG---SPAEPLTIC-PVP-AGEAQTP
QRN------ESDFWLQ----------------------------PY-EPS----------
-----DPALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAGFP
---N---------------------------------SCLL---------GSL-----LI
FILLQLPQ------------------------------------------LDS-AP-FEV
--------I-GPP-EPIVVLVGEDAELPCHLSPNASAERM-ELRWSRKKL-S---P-AVF
VRREAREQAGE----QMAEYRGRATL-VDHDITAGRV-AVRIHEVKASDDGEYRCF--FR
-Q-DE--NYEEA-IVH------L--K-VA-----ALGSDP-----------------HI-
------SMEVQESG-EI-R---L--ECTSVGWYPDPQVQWRTPKG-EVFPS-M-------
------S-------------------ES-RKPDEESLFTVAASVIIR-----D--PSMK-
NVSC-CIRNLL-LDQ-EKEVE-------ISIP-APS------------------------
------------------------------------------------------------
------------------------------------------------------------
----IPR-L-T----------------S----WMV-AAAVI-LMV-----LGLFTIGS--
I-----FFTWRLYKERFRQKK--------NEFNSKXX--XXXX-----------------
--------------------------------------X---XXX---XXXXX-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------XXPVT---L--D-PGSAH
SELV----------IS-----HEKKSVLEGLQ----------------------------
---PHQTCSVL-----------GFEGIT---AGRWY---WE-VE-V--T--DGDRSEWAL
GVCREGVN-R--K-GW--------------------------------------------
---------------YVESPDRGFWVLGRF-----------ESGYCARTNP-T-----TS
---------------------------------LLAV---S---PVGVFLDHEEGDVSFY
NMTDGSH--IFSFPQASF-S-GALFPYFCL--SG-------DVSMTVC-SMA-GGSEGLP
VPLQ----F------------------------FS-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TAQ-FKV
--------R-GPE-RPVAASLGGEAVLSCHLSPSMSAENM-EVRWFRGKF-S---S-VVH
LYRGGKDQYGL----QMVEYQGRTEL-LKDDITNGRV-FLRIHNIRPSDNGQYTCY--FQ
-S-SV--SYEEA-LLE------L--R-VA-----GLGSAP-----------------AI-
------SMEGHQDG-GV-Q---V--VCQSSGWYPQPEAVWRDHQG-QRLPS-V-------
------S-------------------EK-TSQEAGGLFQTETAIVLT-----E--ESNR-
KVSC-HIRNPR-LNQ-ETESV-------ISIA-ELF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-V-N----------------A----WMV-SVWVS-VAL-----LVTVIA--VA
S-----FCFWRQ------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MWNPKAF------SGP----------LCLSLTF-WC
LLICSTDE-------------------------NGK------------FPGLSSAQ-LSC
LPPLGPAAY-SLL-RPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDITAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-EDIPAV--------
--------------------------KAPVVADGVGLYAVAASVIMR-----G--NSGK-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIT-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMEYAATK-------------
----------------QEIS---------LREKLQE-E---LKWR---KIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGDISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-KQVESSP
-N--P--D-----------------------LVPD--------HSLETPVA------PDL
ANESGEPQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LT-------------------------------------------HFTAQ-FTV
--------Q-GPD-QPVPASLGGVADLSCHLSPSMSAENM-EVRWLRSQD-S---S-VVH
LYRDGQDQYAE----QMPEYQGRTEL-LKDEITVGRV-SLRIRDIQPPDHGQYTCL--VQ
-S-S--VSYAEA-LLE------L--Q-VA-----GLGSVP-----------------AI-
------SVEGHQDG-GI-Q---V--LCRSAGWHLQPEAEWRDHQG-KLLPS-A-------
------S-------------------EK-MSQEAGGLFQTEIAIVLT-----E--ESSQ-
KVSC-LIRNPR-LDQ-EKEST-------ISIA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPKD--N----------------P----WMV-PMGVI-PTL-----LVGFIALF--
S-----YGIWRQNR----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
TLKLLEEYVM----------VWK--------------------------------MCVMP
HSQK-------------------TSVCMERPPSTS-----G-----SWFLGCLL-----T
LAFLQLPA-------------------------------------------PV-------
--------S-GDAHKFYLAPLGGTAELPCPLLLWPGMVLS-EVRWQRPAHLPHT-Q-AVH
VFRDGQDRDDD----LMPEYKGRTKL-VRDT-LKGSY-SLSISNVRLEDRGLYQCQ--FR
-V-G--NQSQEG-NVT------L--Q-VA-----VLGSDP-----------------FI-
------HVKSYDAG-WI-Q---L--VCQSVGWFPKPWTEWRDTEG-RVLQSLS-------
--------------------------EA-HFLDETGLFRTAVSSRIR-----D--NSVG-
NVSC-TVRNEV-LGQ-EETTI--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------GAPAPGS
L---S-----S---------------------PA-VALSAV-LPI-----LGLLILLG--
I-----WLICKQKRSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVVVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDK----K--RP-V------------PDN--
PQRFDFVVSVL-----------GSEC FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSDSVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RRNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---RNTAPLIIC-TEL-QKSDESI
FTKQ---------------------------------------------------EGKS-
-KANGDVSLTVNPS---LLSPQGPEL--FPVN---DT---WPSNLGPALQGFKAPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDTSKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GHKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------CCRG-------------SLLSLLPSL----
FLLLQLPA---GGS---------------------------------------AEE-FVV
--------I-GPS-DPIVAMLGGDITLPCRVSPAMNVETM-ELRWFRSKF-S---E-AVF
IYQNQQEQREE----QLAQYTGRTSL-VKDFLIQGEA-AVRIHNVQAFDNGLYTCF--FR
-K-G--SFYEEA-NLE------L--R-VA-----GVGSAP-----------------QV-
------QIQGPEED-GV-R---V--VCMASGWFPKPQLQWRALSG-EKFLT-F-------
------S-------------------ET-HAQDPEGLFNVEATLVVS-----D--SSSG-
NVTC-SVLNPI-LGQ-KKGMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQT--S----------------P----WKP-AFLVI-LTL-----LTLLLLGA--
A-----FYIKREHTAKCREMQ--------EWKKLHRD-KEEDQRTKEEA-LKGR------
------------------------A-----WRKSVY--L--AAWR---KARLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQA-------------MSVT---L--D-PESAH
PRLA----------VS-----DENTSVTWKDTTE--G-----------------------
--TEEETCSVL-----------GHDGIT---SGCCY---WE-VE-IRNGG-KS---DWVL
GVCRGDVE-R--K-GW--------------------------------------------
---------------YVELPKKGFWVVG-K--Y--------DDKFCA--LLET------E
---------------------------------VSLGKVPH---RVGVFLDLKEGDVSFY
NMADGSH--MFSFSLASS-S-GALFPYFRLKPGD-V-------SLTIC-SVL-GGPVETP
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGA---VASFLFVP
LTMKQSDDFRVIDPARP-ILAGVGEDALLTCQLLPKRTAIHMEVRWYYSEPSPHVLFAYL
NGAEVTEMQMEEYRGRVEWIED-DIAKGSVALKMYNIP-SDNE----QFQEGNYCGETNF
LLKVAGLEGS-RKCME---------GS---VE---------------------------S
GVQLVCTAKGWF----------PEPQ---VY---WEDITGKKL-----------------
-LAISEYHFQDKD--------------------------------G------------LF
YVEAMLMVRNAS----------------------------------AENVSCFIHS----
PVFTE-EG------------------------------LVI--SILEK-LQSELXXXXXX
--------X-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX-X---X--XX
XXXXXXXXXXX----XXXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXXXXXXXXXX--XX
-X---XXXXXXX-XXX------X--X-XX-----XLDSSP-----------------LI-
------TMERLKNG-EK-Q---L--MCTPEGWFPPPHVQRRDIEK-T-TPSV--------
--------------------------SE-LTQGGQGLFQVKAFLLVT-----N--ISVM-
YVTC-AIN-PF-LAT-KKMAT-------FSLS-DW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVEFPGYSLSGM---IASCFLIL
LTVKQQDDFRVLGPEGP-ILARVGEDALLTCRLLPKRSAAHMDVLWYRSEPRAAV-TAPQ
GGADMVEVQVQECRGRLEMLED-GVAEGSVTLKIRSVQPSDSGQYWCRFQDRDYFGETSL
LLQVAGLGSAPHIHIM---------GN---QS---------------------------G
GVELLCTAEGWF----------PEPH---VR---WEDRWGERL-----------------
-LAVSEHHVLGED--------------------------------G------------LF
RVEDMLVVGNVSVV--------------------------------TETVSCFIHN----
PVLEDGKG------------------------------AVL--NLPEK-LQTEMAS-LQV
--------I-GPS-QPIPVRVGEDIQLTCYLSPKTNAQGM-EVRWVRSLW-Y---P-AVY
VHANGDLMAGE----QMSEYRGRTSL-VSDAIQEGKL-TLQIHNARASDDGWYRCL--FE
-S---DGVYQEA-SME------L--K-VI-----AVGSTP-----------------LV-
------TVERRKAG-EK-Q---L--TCTSDGWFPQPHVQWKDTEG-RIVPSDP-------
--------------------------AV-LHQGQNGLFDVESHLLVT-----N--SSVM-
NVAC-SISNLP-LGE-EKTVA-------VSLS-ESKK-----------------------
------------------------------------------------------------
-----------------------------------------------------------N
F---------S---------------------WKMLPVSGL-LLVVT-------------
I-----GLIWMKS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MAVS
---P---------------------------------SALP---------RCL-----LT
LILLQLPP-------------------------------------------LDSTP-FEV
--------L-RPP-EPILAVVGGDAELPCHLPVNASAQRT-ELRWFRHTF-S---P-AVL
VLLAGREQEDE----QMPEYRGRASL-VPAVLAGGRA-ALRIRAVRASDDGEYRCI--FR
-K-DS--SYQEA-AVS------L--K-VA-----ALGSDP-----------------HI-
------HMEVQENG-EI-R---L--ECTSVGWYPEPRVQWRTSRG-EKLAS-T-------
------S-------------------ES-RSADEEGLFTVATSVVIR-----D--TSLG-
NMSC-CIQNPL-LGQ-EKEAG-------VSIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-P----------------P----WIV-AVAVI-LIL-----LGLLTIGS--
I-----FFIWRLYKERAKERK--------HAFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLHA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVCLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRETLT---LGRHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDCDAGDVSFY
NMTDGSH--IYSFSNISF-S-GPLRPFFCLWSCG-------KKPLTIC-PTA-GGPEGVT
VAAD----A------------------------QG--------LSKDIPLS---PMGEYA
ASGDTDT---LHSK---LIPTQPGQG--TP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLP---------GCL-----LV
FI-LQVPE------------------------------------------LDS-AP-FDV
--------I-GPP-GPILAVVGEDAELPCHLSPNVSAERM-ELRWFREKI-S---P-AVF
VRREGREQPGE----QMAEYRGRVTL-VEDRIKEGRV-AVRIQDVKASDDGEYRCF--FR
-Q-DE--NYEEA-TVP------L--K-VA-----ALGSDP-----------------HI-
------HMEVQESG-EI-W---L--ECTSVGWYPEPRVQWRTPKG-EEFPS-V-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSMK-
NVSC-CIRNLL-LGQ-EKEVE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVV-LMV-----LGLLTIGS--
I-----FFTWRLYKERSRQKR--------HEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GREAFT---SGRHY---W--VE-V------GDRTDWAI
GVCXXXXX-X--X-XX--------------------------------------------
---------------XXXXXXXXXXXXXXX-----------XXXXXXXXXX-X-----XX
---------------------------------XXXXXXXR---RVGIFVDCESGDICFY
NMTDGYH--IYTFSNASL-S-GTLRPFFCVWSCG-------KKPLTIC-PIT-NGLEGVT
VVAD----P------------------------KD--------LYKDIPLS---PTGQDS
ASGDTDT---LHSK---LIPPQPSQR--VR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------METT--GL---SFS--------RYF------AV
MNLLQ-MT------------------------------------------IPSSG--MTL
--------S-YPY-GPILAPLGGKVELSCQLSLPESTEHV---------E-I--------
--RWFWNLYGE----TISKYVEWTEL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--DVCEEA-ITE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNSK-GL-L---V--ECNSEGWFPQPQMEWKDSRG-EIILP-A-------
------S-------------------KS-HSQDRNKLFNMKMSLLLR-----D--SSHG-
NITC-YLQNPV-TGQ-EERIS-------VVLS-DKLFP-------WNSIWILILVAILAV
LLF-FIMLPSVEL-QQREQRNNWCD---------------------------------WN
-------PPCLIGIGIVFFS---MCVIVGLIIGLRRR---------------NRGMWIKR
M---GMS-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLRPA-------SLTSR------LVFFTHLLL--
---LRPGE------------------------------------------PN-PEK-ITV
--------V-GPA-DPILALVGEEVEFSCHLWPYLDARHM-EIRWFRSHT-S---D-VVH
LYQEQQELLDR----QMEAFRNRTKL-VKDDITDGSV-ALQLHSIVPSDEGTYGCR--FL
-S-D--NFSGEA-VWE------L--E-VA-----GQGSEP-----------------HL-
------SLEGSKEG-GI-Q---L--RLRSSGWYPKPKAQWRNHQG-QCLPP-E-------
------F-------------------EA-IVRDSQGLFSLETSVIVR-----E--GALS-
NVSL-SIQNLL-LGQ-KKEYV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------R----WKG-AFVGT-VAL-LPPLLAVLVALA--
L-----GLLQKQRRRREKLEQ--------QAEK-RQG---KLTAELE-------------
------------------K----L----HWRRAEGQ-----AEWR---AAQKYA----AD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGRSVFSR---GAPP--SP-A------------PSD--
PQRFSEQKRAL-----------SLQR FS---VG RHY---WE-VH-V------GCSSRWLL
GACLAAEP-R--S-PP--------------------------------------------
---------------VRLSPAAGYWVLGLW--N--------GREYFVLAPH-R------V
--------------------------------PLTPRVPPR---RVGVFLDCQAGKLSFF
NVSDGSH--IFSFHDTF--S-GALRAYFRPRAHDGG---EHPDPLTIC-PLP-AKGPCVP
EEN------DSDTCLQ----------------------------PY-EPA----------
-----DSALD-------PW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SFL----------AFLLLNFRVC
LLLLQ-------------------------------------------LLMPHSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNNKG-ENIPTV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------S----WIA-ALAGT-LSV-----LLLLLGGA--
G-----YFLWQQQEEKKTQ---------FRKKKREQELREMAWSTMK-------------
----------------QEQS---------TRVKLLE-E---LRWR---SI---Q------
----------------------YASR----------------------------------
------------------------------------------------------------
------GERHS--------------------AYNKWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCES FI---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LKLPKPPT---KVGVFLDYETGDISFY
NAVDGSH--IHTFLDVSF-S-EALYPVFRILTLEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFP
---VS-------------------PDSLKPA-------SPPGG------LIFLTQ-----
-------------------------------------------------------E-VTV
--------V-GPG-EPILALVGEEVEFPCHLSPYLDAQHM-EIRWFRSRT-A---D-VVH
LYRERQEFPGR----QLAQFRNRTRL-IKEGILDGSV-VLQLRSVAPSDQGLFGCR--FL
-S-G--NFSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------FLEGFKKG-GI-Q---L--RCSSSGWYPKPKAQWRDHQG-QCLPP-E-------
------S-------------------EA-IIQDAQGLFSLETSVVVR-----G--GAHG-
NLSL-SILNLL-LGQ-KKELV-------VQIA-GQWLPSTFLFPV---------------
------------------------------VTLSVLSREAQGPA----------------
-------------------------------------------------------VLIPP
F---PLAA--S----------------D----WRR-AEGQA-------------------
--------------GEPPAAP--------GRP----------------------------
-----------------------------LP---RV--------------LCTP----EG
D-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------L---R--S-RLAAA
PSLE----------VW-----RTGSSVSLARRGAGPQSGPD-H------------AAA--
GGAGATKACAL-----------SPPSAS---PGPPL---YTWMT-G------GAARPWFL
RACLAGGT-P--------------------------------------------------
--------------------GPRYWVLALR--G--------GGEYLALGAR-P------V
--------------------------------PLAPRVPPL---RVGVLLDCGDGDG---
------------------------------------------------------------
---------DGDAWVQ----------------------------PY-EPW----------
-----APAPG-------LP-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TKMA------SDL----------DFFLLDFLAC
LVLVQ-------------------------------------------LLMPCSAQ-FAV
--------H-GPP-GPILAMVGEDADLPCHLSPMMSAETM-ELRWVRSSL-R---Q-VVT
VYAGGKEVENK----QTPEYRGRTSI-LRGDITAGKA-ALRIHSVKASDSGNYLCY--FQ
-D-G--NFYEKA-IVE------L--K-VA-----ALGADL-----------------HM-
------EMKGYEDG-GI-H---L--ECRSTGWYPQPHVQWRDAKG-EVIPAV--------
--------------------------AAPVVADGAGLYAVAASVIMR-----G--SSGE-
GVSC-TIRNSL-LQQ-EKTAR-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FKSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAVV--
G-----YFLWKQQEEKKTL---------LREKEREQEMRELAWSTTE-------------
----------------QERS---------TREKLEE-E---LKWR---KIQYLA------
----------------------LCG-----------------------------------
------------------------------------------------------------
--------KSP--------------------AYNGEH-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SD-FRV
--------L-GPP-EPLLAIVGQDKELPCKLSPSISAEGM-ELRWYRDQP-S---P-AVH
VHQNGDDVYEE----QMAEYRGRTTF-IGDRMLRGEA-TVRIHNVTMFDNGTYHCI--FR
-E-H--TSHNQA-TLW------L--K-VA-----GLGSSP-----------------VL-
------HVTDSQDK-SI-R---A--ECTSAGWFPEPEVEWLDLRG-QPVPA-E-------
------T-------------------HF-SPSASTGLLTVVSMVTVQ-----E--RTVE-
GLTC-SISNPL-FPE-KKLA----E---TYLP-DALGVVW--------------------
------------------------------------------------------------
---------------------------------------------A----------FATP
L---FRRP--P----------------S--TERGP-VLPLI-LTA-----LGLVTAAI--
A-----CAFGRSHKEDKSEEE--------EDADPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AG-A-------------------EAEPFHASLS---L--D-PETAS
PKLI----------VS-----EDRKSVKRLLF----D--QD-L------------SPS--
SRRFDQDPCIL-----------AQER FD---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TC
---------------------------------LSPPQPLR---RVGISLDFETGEISFH
NVANGSL--IYVFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVI-RETEENT
ESSG----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSLRSC-----QLASL-F-----
FLVLSLFV-------------------------------------------LVSAQ-FTV
--------I-GST-EPILAMVGENTTLYCHLSPERNAEEM-EVRWFRWRF-S---P-AVL
VYRGHRERPEE----QMVAYRGRTTF-MSTDISKGRV-GLVIHNVTAYDNGIYSCY--FQ
-E-G--RSYDQA-VME------L--M-VA-----SLGSEP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYD-EVVPALE-------
--------------------------EE-YTADREGLFTVTMTIIIR-----D--CSVR-
NMTC-SVNNTR-LSQ-ELESV-------ILIP-EFFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SF--P----------------L----WMV-AVAVT-LPVVMLILF---TSG--S
V-----CLVKKHHRKKLI-LS---------------AEKEAEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----EAARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDRRSVIR--GPSR----QS-V------------PDN--
PERFDCRPCVL-----------GRET FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RVAVFLDCEGGDISFY
NMRDRSH--IYTCPPVRF-T-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLFLYKTRPISQSLVRKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
-------AFSVIGPVQL-IQAKQGEDVTLSCELSPKMDAQDMMVNWSGT----RLVYRYS
NREKLEEFQGAEFQGRMELLHH-DMAEGKVILRIHHVQVSDSGQYTCCIQAPDNYNETHV
ELQVAGLGTAPHIRME---------RP---VN---------------------------K
RIRLVCTSRGWF----------PEPQ---AK---WRYVGREEP-----------------
-L-SSKTQILVID--------------------------------G------------LF
HVEMSLMIREDS-S--------------------------------GRNVSCSIYN----
PILDEEKV------------------------------SFX--XXXXX-XXXXXXH-FTV
--------I-GPA-EPILVKLNEDVLLPCHLSPKMSAEHM-ELSWFRSHF-S---D-AVF
VYRNGKAQDEE----QAVEYRGRIEL-VKDTIAEGNV-TLRIRSVRLSDSGQYWCR--FQ
-E---NLEYGEA-KSE------V--I-VT-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MADCPGYSLSGV---AASLLFIL
LTVKHPDEFRVTGPALP-VLAKVGEDALLTCQLLPRRTAAHMEVRWYRSDPDAPL-IVHR
HGAQVAGLQVEGYRGRVEWTEDS-ADEGSVSLRIRQIHPGDDGQYWCRFQEGDYWGEASV
LLQVAALGSSPNIHIE---------GP---GE---------------------------G
EVQLVCISQGWF----------PEPG---VY---WEGSWGEKL-----------------
-LSFSENHMLGED--------------------------------G------------LF
YVEDTLVVRNDT----------------------------------SETISCSIYN----
RDLKEAKE------------------------------ATI--VLPAR-LYLKLHPVSLV
--------T-GPS-QPILVRIGENIELTCHLSPQADAQSM-EVRWVRSHY-Y---P-AVH
VSVDGAHWAGE----QMAEYRGRTVV-MPDAIHEGKL-TLQIHDARISDDGEYRCL--FG
-K---DGVYQEA-RMD------V--Q-VM-----VT---D-----------------RW-
------DRQVVKGS-GI-M---L--ACPC--YLVEQAIPWSAQG----------------
--------------------------------------------SMG-----T--KSVV-
NVTC-SLSLPG--GE-EKAAR-------LPLS-DSKI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMALPVLVL-PLAMA-------------
I-----DLIKVKH--RPR-------------RSNQQNLK---------------------
---------------------------------N-DE-S--HRRV---S-----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------L------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MS
---PGSR---AA----------ASEQGMAKT-RCGR-ASLLRC------------T--VA
FLFLQLPPP---G--------------------------------------NGRAD-FQV
--------Q-GPH-APVLALVGEDAELSCRLVPSISTEGM-ELRWYRNQS-S---P-AVL
VHRNGEDVHQE----QMVEYQGRTSF-VSDHVARGEA-TLRIHNVTLFDNGTYHCL--FK
-E-G--TSSNQA-TLW------L--T-VA-----GLGSKP-----------------RV-
------QVVDDQGT-GI-Q---V--KCTSAGWYPEPLVEWRDLRG-QPVPA-V-------
------T-------------------NF-SLSATTGLVAVVSRVTVQ-----N--RAVQ-
GLSC-SISNPL-LPE-RKEAE-------SWLP-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------E
C---L-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGV---AASFLFVL
LTMKHPDDFRVVGPALP-ILANVGEDALLTCRLLPKRTTARMEVRWYRSDPDTPV-MLYR
DGAEVPGLAMEGYRGRVEWMEDS-TEEGSVALKIRQVQPGDDGQYWCRIQEGDYWREASV
LLQVAALGSSPNIHVE---------GP---GE---------------------------E
GVQLVCTSRGWF----------PEPE---VY---WEGIRGEKL-----------------
-MSLSENHVYGED--------------------------------G------------LF
SVEDTLVVRNDS----------------------------------VETISCFIYN----
RGLREPQE------------------------------ATI--ALPEK-LQTELAS-SRV
--------I-GPS-QAIPVRVGETIELTCQLSPQTDAQSL-EVRWLRARY-Y---P-VVH
VYTNGAHEAGE----QMAEYRGRTSL-VTDAIHEGKL-TLQIHNARTSDEGQYRCL--FG
-K---DGVYQEA-RVD------V--Q-VM-----AVGSTP-----------------QI-
------TREVLKDG-GT-Q---L--RCTSDGWFPRPHVQWRDRDG-RTLPSFS-------
--------------------------EA-FRQGSQELFQVETLLLVT-----N--GSMV-
NVTC-SISLPL--GE-EKTAR-------FPLS-DSRI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMTLPVLVL-PLAMA-------------
V-----DLIKVKR--RTKDQK--------H-NGNRENDR---------------------
---------------------------------N-GE-S--QRRR---LSS---------
---D--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-E----
--------------RL-----R--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------VNAHLF--LD
LFINGPQL-------------------------------------------IILGQ-FHV
--------I-GPK-APVIALVGEEAELSCHLSPMMDAQNM-EVRWHRNNP-F---G-LVH
LYKNFQDHIEK----QKPDYGERTEF-LKDNITKGDV-TLRIRHIRPSDGGEYRCL--FE
-S-S--SYFNEA-QFQ------V--L-VT-----GSGTAP-----------------HI-
------HIDHSASK-GL-N---L--TCMSMGWYPEPEVEWRDLQE-QRLAP-A-------
------S-------------------ET-KTPEMNGLFRVETSVLLD-----E--STKG-
NVSC-SIRNPV-LDV-EKEV----H---ISVS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPRV--S----------------P----WPV-AVPVIVVLL-----VIIGIML---
V-----KVSYLPRKEHTCL----------VHKLRS-------WNNISHSAPTAPM-----
--------F-KEWSQLKSPDNIQ------IKAG---------------RL---------K
LE----------------------------------------------------------
--------------ISASGY-F--------------------------------------
--------KRLSYVKW-RT-------------------SSFSSEDIK---L--D-KATAH
PYLS----------VS-----ADEKYVITVPE----K--QD-V------------PDI--
PERFDTLLAVL-----------GQNSFC---GGNHY---WE-VQ-V--AG----NSRWTV
GLCWDSIN-R--KGHY--------------------------------------------
---------------ISACPENGFWTIC-L--K--------KGVDRALSTP-R-----YT
---------------------------------LNVPEPLL---TVGIFLKYEEGLIFFY
NVTDCII--LYIFKS-NF-T-KPMRPYFYPGHFIE----ENPNGLTIT-KVP-KTNPPTL
PRAE-----------------------------------------------FR-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EIRWFWNHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--S----------------P----WKG-ALVGA-LAA----LLAALAALA--
L-----GFLRLRRRCQEKLKK--------EAQK-REG---KLTAELE-------------
------------------KLQKEL----DWRRTEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--DP-V------------PSD--
PQRFSEQTCAL-----------SLQRFS---AGRHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGVFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---ERPDPLTIC-PLR-VR-TRVP
EEN------DSDTWL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------K-NIITSV------LFSLTSI--LL
VIVSYSIS-------------------------------------------LSPGE-FHV
--------I-GPK-APVIALVGKEAVLPCHLNPLMNVQNM-EVRWFQINP-F---V-LVH
HYKNFQDHLEQ----QRPEYRGRTEF-LRDNITEGHV-ALRIHHIRPSDGGKYSCF--FE
-S-S--TYFNEA-QFQ------V--L-VT-----GSGTAP-----------------HI-
------RIDLGETK-GL-V---L--TCTSAGWYPEPEVEWRDLQG-QRLLP-A-------
------S-------------------ET-KTPERSGLFHVETSITLD-----K--SSAG-
NVAC-SIRNPV-LKE-EKEV----H---ISVT-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------D
L---FPRV--S----------------P----WPV-AVPVIVVLL-----VTIGIIG---
V-----LLIVLFIAIISVN----------FLCMFK----------ISSE-----------
------------NKDLSGSKEIL------LQKT---------------Q-----------
------------------------------------------------------------
-------------------V-R--------------------------------------
--------LQGSEELW-RL-------------------ARIYQKDIK---L--D-ATSAH
PYLS----------VS-----DDGKCVTSLQQ----K--QH-V------------CDF--
PERFDTLVAVL-----------GQKCFS---GGRHY---WE-VG-V--AG----KNKWKL
GLCMDSVN-R--KGQY--------------------------------------------
---------------TRACPENGFWAIS-L--K--------NGVYQALSTP-R-----YS
---------------------------------FNVPESLL---IVGIFLNYEKGLIIFY
NVTEFTT--LYTFKS-NF-N-QPLKPYFYPG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LSSKP-----------------LV-
------EMKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG-EVVPALE-------
--------------------------EA-YTAGANGLFTVTLAVIIR-----D--DSVR-
NMFC-SIHNTR-LSH-EVEAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVI-LPTLMLL-----MAG--G
G-----CLVKKLQKEKEV-LAVEKEVLA-VEKEVEREEKEIAY-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------QLQEELGW--------------------RRTVLHAADVV---L--D-PATAH
PELF----------LS-----EDSRSVFR--GTRR----QE-V------------PDD--
PERFDLWPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVRAWAV
GVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGGGVWALELF-----------GGQYRPLAAPAL------L
---------------------------------LPLRERLG---RVGVFLDYEAGDVSFY
HMRDRSH--IYTCPRSAF-A-GPLRPFFRLGNYFCP-------L-AVC-PAF-VGAQGVT
VPE--------AGLVLHAAGFRRGP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FLGFLKQI-------PRCLS------IFF-T-YLL--
--FLQLWE------------------------------------------VN-SDK-VWV
--------L-GPE-ESILARVGEAVEFPCRLSSYQDAEHM-EIRWFRAQV-S---N-VVY
LYQEPQGRSSL----QMAQFRNRTLF-EAYDIAEGSV-NLHILKVLPSDEGRYGCR--FL
-S-D--NFSGEA-TWE------L--E-VA-----GSGSDP-----------------HI-
------SLQGFSGE-GI-Q---L--QCSSSGWYPKPKVQWRGHQG-QCLSP-E-------
------S-------------------EA-ITQNAQGLFSLETSVIVR-----G--GAHS-
NVSC-IIQNPL-L PQ-KKEFV-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRM--S----------------P----WKK-AFVGT-LVV-LPLSLIVLTMLA--
L-----RYFYKLRSFQEKQVK--------QGEE-VRE-----------------------
------------------KLQTEL----DWRRSEGQ-----AEWR---AAQQYA----AD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----NNGKTVSSR---LGVP--SI-A------------AGD--
PQRFSEQTCVL-----------SRER FS---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--S-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------RCEYFVLDPH-R------V
--------------------------------ALALRVPPR---RIGVLLDYEAGKLSFF
NVSDGSH--IFSFTDTF--S-GALRAYLRPRAHDGS---EHPDPMTIC-SLP-VRGPQVL
EEN------DNDNWLQ----------------------------PY-EPL----------
-----DPAWAVNEA---VS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPV-------SLTSS------LVFFMHLLL--
---LRPGE------------------------------------------PN-PEK-TTV
--------V-GPE-EPILALAGEEVEFSCHLSPYLDAQHM-EIRWFRSRT-S---D-VVH
LYREQQELLGT----QMEAFRNRTKL-VKDDITDGSV-ALQLRSIAPSDEGMYGCR--FL
-S-D--NFSGEA-VWE------L--E-VA-----GQGSEP-----------------HL-
------SLEGSKEG-GI-Q---L--RLRSSGWYPKPKAQWRNHQG-QCLPP-E-------
------F-------------------EA-IVQDSQGLFNLETSVIVR-----E--GALS-
NVSL-SIQNLL-LGQ-KKDYV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------R----WKR-AFLGT-MAV-LPPLLAVLVALA--
L-----GLLQKQRRRQEKLKK--------QAEK-RQG---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDCKSVRSR---GAPP--SP-A------------PSD--
PQRASEQKCAL-----------SLER FS---AG RHY---WE-VH-V------GCSSRWLL
GACLAAVP-R--S-RP--------------------------------------------
---------------VRLSPAAGYWVLGLW--D--------GCEYFVLAPH-R------V
--------------------------------ALSPRVPPR---RVGVFLDCQAGKLSFF
NASDGSH--IFTFHDTF--S-GALCAYFRPGAHDGG---EHPDPLTIC-ALP-VKGTCVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DSALD-------PW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ARSC-----G-----SQLSSCLI-----T
LIFLQLPV-------------------------------------------PA-S--R--
--------T-GDAGKFHLAPLGGTAELLCPISLWPVTEPR-EVRWLRSPHPQ-RSQ-VVH
VFRDKKDWDEE----LMPEYKGRTAL-VRDP-QEGSV-TLQIRDVRLEDRGPYRCL--IQ
-I-G--NLSRED-TVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------LA-VALAVI-LCV-----LGLLIMVC--
L-----WLIWKQRRSKEKLLYE--QVMEVE-NLLSDHAREK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVV VT---L--D-PDTAH
PKLI----------LS-----EDRKCVRLGDR----R--QP-V------------PDN--
PERFDFVVSVL-----------GAEY FT---AGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------GRNKYEALTSPQI------S
---------------------------------FRLKEPPQ---CVGVFLDYEAGVVSFY
NVTDKSH--VFTFTDSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QKSEELV
VPKP---------------------------------------------------EGKH-
-HANGDVSLKVNPS---LLPAQDPEL--FSLR---DMTLSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MA---------DFPGY-----SLSGV-VA--SF
F-FTLLTV-------------------------------------------KQSDD-FRV
--------V-GPA-FPVLAKVGEDALLTCQLLPKRTAMHM-EVRWYRSEP-D---T-PVS
VRWDGAEVTEP----QMEEYRGRTEW-IEDSMAEGKV-TLKIRRVQPSDDGQYRCR--FR
-E-E--NYWGET-SAL------L--Q-VA-----ALGSSP-----------------NI-
------HMEGTGEGGGV-R---L--VCTSQGWFPKPQVYWGDIWG-KRLLT-F-------
------S-------------------EN-HIPGEDGTFYVEDTLMVR-----N--DSVE-
TVSC-FIYNHL-LGE-AKEAT-------AAFP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------K
L---RTEM--E----------------S----KMP-FLWKI-LPV-----LGLFLAIA--
V-----GLIKRRSST---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------K-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MADCPGYSLSGV---AASLLFIL
LTVKHPDEFRVTGPALP-VLAKVGEDALLTCQLLPRRTAAHMEVRWYRSDPDAPL-IVHR
HGAQVAGLQVEGYRGRVEWTEDS-ADEGSVSLRIRQIHPGDDGQYWCRFQEGDYWGEASV
LLQVAALGSNSNIHIE---------GP---GE---------------------------G
EVQLVCISQGWF----------PEPG---VY---WEGSWGEKL-----------------
-LSFSENHMLGED--------------------------------G------------LF
YVEDTLVVRNDT----------------------------------SETISCSIYN----
RDLKEAKE------------------------------ATI--VLPDS-KIA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
L---------L---------------------WMALPVLVL-PLAMA-------------
I-----DLIKVKH--RSKDPK--------H-HSNQQNLK---------------------
---------------------------------N-DE-S--HRFP---S-----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-Q----
--------------RL--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVT---------------------PRLSSLL---
------------------------------------------------------------
------------------------------------------------------------
LALLQLQV------------------------------------------LCA-AR-FDV
--------I-GPA-EPVLAAVGSDAELPCSLSPNVSAEHM-ELRWVREAP-L---P-AAL
LHRDPQGR-------SAPEFRGRVKL-VADGIATGRA-AAQIHRVRAADEGDYRCL--FR
-D-DA--SSGEA-TVR------L--R-VA-----ALGSDP-----------------HI-
------SMEVQESG-EI-W---L--QCTSVGWYPEPHVQWRTPTG-EKFLS-T-------
------S-------------------ES-RSPDQDGLFTVAASVIIR-----D--TSLE-
NVSC-CIRNLL-LDQ-QKEEG-------ISLS-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-S----------------P----WQV-AVAVV-LTV-----LGLLTIGS--
I-----VFIWRLYKDRFRERK--------SEFSSK-------------------------
-------------------------------EKLLE-EL---S---------KF------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------LDVT---L--D-PDTAH
PHLF----------LY-----GDSKSVRLEDS----R--QK-L------------PEK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAV
GVCKEDVM-K--K-GF--------------------------------------------
---------------DPLTTENGFWAVELY-----------GNGYWALTPV-R-----TP
---------------------------------LPLAGSPH---RVGIFLDYDSGDISFY
NMTSGSH--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-SVV-NGPEEVK
VIGD----T------------------------QG--------LSKDIPLS---PMGKES
ASEDADT---LHSK---LIPLQASQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------HGL--------
-------VHSNC-LEE------L--KLGT-----SSGADP-----------------HL-
------SLGGYESR-GV-R---V--LCRLAGWYPLPQLLWTDARG-QHLPS-V-------
------S-------------------QT-HSQDQEGLFEIEGAVIVT-----G--SVEG-
PLSC-VVRNSR-LQQ-ERKF----S---LHIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FHNA--Q----------------P----WIV-ALAL-VLVL-----LAVSIGLG--
V-----YLFRKQGKLAAQGPP--------W------V-----WS----------------
--------------------GAE-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------PW-PR-----------------EMRRRRKVKVT---L--D-PHTAH
PELV----------LS-----QDNSSVRREIK----W--QQ-L------------PDT--
PERFNYRCCVL-----------GREEFR---EGRHC---WL-VE---VEGERLKDSWWAV
GVSRDSVE-R--K-GR--------------------------------------------
---------------INMSPEEGIWALQ-Y--F--------HGQLMSLTSP-P-----TP
---------------------------------LSVSPVPT---RIWVCLDCTHGQLSFN
NADNGVQ--IFTFT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MEMA-----S-----SWLLSCLI-----M
LVFLQLMV-------------------------------------------PMSV-----
--------H-TGDSKSHMAPLGGTAELLCPLSLWPVTVPN-QVRWLRSPHLG-HSQ-AVH
VFLNGQDQDDE----QMPEYKGRTAL-VRDS-QEGSV-TLNIHDVRLEDRGLYLCQ--VH
-I-G--NLSREG-SVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------SE-VVLAVT-LPV-----LGLLILAG--
I-----GLIWKQRRSKEKLLYE--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVKLGDR----R--QP-V------------LDN--
PQRFDFVVSVL-----------GSEYFT---GGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------RGMEYEALTSPQT------I
---------------------------------FRLKEAPQ---CVGIFLDYEAGVISFY
NVTDKSH--IFTFIHSF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKLESSV
VSKP---------------------------------------------------EKKS-
-CANGDVALKADPS---LPFP----V--IPHT---DSILPWSSDLGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FL-----SSL-----LFICLM-----F
LFSLQMPV-------------------------------------------RGTEQ-FVV
--------L-GPT-EPIVALLGTDIILPCLLSPLMSAEHM-EVRWFRSQF-S---E-AVI
VFQKGKEETDE----QLVEYTGRTEL-ISEFITEGRL-AVKIYNVQISDNGKYQCY--FR
-K-G--DVYEQA-SLE------V--K-VA-----GLGSAP-----------------HL-
------RLEGHEDG-GV-K---L--ACMADGWFPQPQVQWRDNRG-GKLSS-L-------
------S-------------------ET-QAQDEAGFFHMKALIVVQ-----E--SSVR-
NVSC-SICNKL-LSQ-EKIS----A---IDIP-GQFSVLKRMIRV---------------
------------------------------------------------------------
-------------------------------------------GVDG-----T-GERTIS
F---FPKT--S----------------P----WKK-ALSGI-LPV-----VGILLGIS--
I-----FFILKERKK-TKKLL--------QEKKEDKKDKGKGEK-QSG------------
--------------------E---------MSRNFV--L--VSWW---KAHIYA----GE
SLLFPRT---TISGDFLSWLHKRGRKGTRMKAEGGCKDSVESAMVSLWDCPTDPRTLHLF
YPLWKRDSGMRKQPSCTVSFAKAFHNTRFSIGSQLLSSSDEGGPCAERNLWQGLIRERLG
ASS-----------SW-PL------SHAFSWTC--IDLVSLSAVNVT---L--D-PASAH
PGLV----------LS-----RNGKDTKVENA----------------------------
VKNAEEKCSVL-----------GREPIT---SGRHY---WE-EK-V--EMEAQNKATWYL
GICREGVS-R--S-GW--------------------------------------------
---------------VRESPEEGFWIIG-C--Y--------DGTFQPIVSK-Q-----SV
--------------------------------APSLEKPPE---QIGIFLDCEAGDVSFY
NMTDGSH--IYNFPPASF-S-GPVHPYFSIQT-LDT-------SFTIC-GVS-DRPESIP
APSL----E------------------------TP--------GTAQE------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKGSPSVP-----PA--------GCLLPL----
--LLLLFT---GVS-------------------------------------GEVSW-FSV
--------K-GPA-EPITVLLGTEATLPCQLSPEQSAARM-HIRWYRAQP-T---P-AVL
VFHNGQEQGEV----QMPEYRGRTQM-VRQAIDMGSV-ALQIQQVQASDDGLYHCQ--FT
-D-G--FTSQEV-SME------L--R-VI-----GLGSAP-----------------LV-
------HMTGPEND-GI-R---V--LCSSSGWFPKPKVQWRDTSG-NMLLS-S-------
------S-------------------EL-QTQDREGLFQVEVSLLVT-----D--RAIG-
NVIC-SIQNPM-YDQ-EKSKA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKT--C----------------P----WKV-ALVCS-VLI-----LLVLLGGI--
S-----LGIWKEHQVKRREIK--------KWSKEHEE-MLLLKKGTKSV-LKIR------
------------DD-----LQADLD-----RRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQE-------------APVR---I--N-YEMPD
QDKT----------DS-----RTE------ENRG--EE-----------------TVSSS
--QVDHNLITL-----------SQEGFM---LGRYY---WE-VD-VKDTE------EWTL
GVYELCTQ-D--A-S---------------------------------------------
----------------LTDPLRKFRVLE-K--N--------GDGYRALDFCSQNINSEEP
---------------------------------LQLKTRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFAQVPF-L-GSPYPYFTRNSMG-L-------SATAQ-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------NFL----------AFLLLNFHVC
VLLLQ-------------------------------------------LLMPHSAQ-FAV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-ENIPAV--------
--------------------------EAPVFADGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------N----WIA-ALAGT-LPV-----LLLLLGGA--
S-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------IREKLLE-E---LRWR---SMQY--------
--------------------------T---------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LELPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFMDNYF-S-EPLYPVFRILTLEPT-------ALTIC-PAP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARP-HHGDAATLPSF----LVT---FIF--LQ
LLPAG----------------------------------------------NGKSD-FRV
--------L-GPP-DPLLAIFGQDKELLCKLSPNISAEGM-ELRWYRDQP-S---T-AVH
VHKNGEDVYEE----QMVEYRGRTTF-VGNHMVRGEA-AVRINNVSMFDNGTYHC--VFK
-E-H--TSYSQA-TLW------L--K-VA-----GLGSSP-----------------RI-
------HVTDTQDK-RI-R---A--ECTSTGWFPEPKVEWLDLRG-QPVPA-E-------
------T-------------------HF-SATASTGLLTVVSIVTTK-----D--RAVE-
GLTC-SITNPL-LPE-KKVA----E---TYLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---FRMP--L----------------S--AERVP-VLPLI-LAA-----LGLVTAAI--
A-----CAFGRRHKEDKSEEE--------EEVDPR-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AS-A-------------------EVEPFHDS LS---L--D-PETSS
PKLV----------VS-----ENQKSVKRLLF----D--QD-L------------SPS--
SKRFDQDPCIL-----------AQEQ FD---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TH
---------------------------------LSLPQPIC---RVGIFLDFEAGKISFH
NAVNGSL--IYVFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-RETEEVT
DSSE----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EMNGSLAFP-----QA--------ACLLPL----
--LLLVST---GVS-------------------------------------GEVSQ-FFV
--------K-GPT-EPIMVLLGTDATLPCQLFPGQSASHM-HIRWYRAQL-T---P-AVL
VFHEGQEQGDA----QMPEYRGRTQM-GTEAIAMGNV-ALHIQQVQASDDGLYHCQ--VT
-Y-G--FTSQEA-AVE------L--R-VI-----GLGSAP-----------------LV-
------RMTGPENN-GI-R---V--SCSSSGWFPRPTVQWRDTAG-NTLLS-S-------
------S-------------------ES-QTQDGDGLFRVEASLLVT-----D--RAVG-
NVVC-SIQNPL-HDQ-EKAKA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--F----------------P----WRS-ALAAC-LLM-----LFILFSAI--
S-----LATWKVHQHKEQVIK--------KKSEEFQE-TQQMRKEMKFA-VKIR------
------------DD-----LKADLD-----RRKALY--RE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQL-------------APVK---I--N-HEVPD
QDKC----------GP-----ETE------ESSR--EETAE-P------------SLSNP
--PGDHNVITL-----------YQEGFM---LGRYY---WE-VDVVGDTE------DWTL
GVYELYTQ-D--V-P---------------------------------------------
----------------SKESLKKFRVLE-K--K--------GDEYRALTFCSQNVSLEEP
---------------------------------LLLETRPL---KIAVFLDQEDNDLSFY
NMTDETH--IFSFAQASF-L-GSLYPYFTRHARD-L-------SPSQS-H----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MNMAHFP
---N---------------------------------HSVL---------SGL-----VA
VFFLQLLT------------------------------------------VIS-AH-FTV
--------I-AHT-EPLLVMAGEDAMLHCHLFPKKSAEQM-EVRWFRSHF-S---P-AVY
IYKYGKERDEE----QMEEYRGRTTF-VRDNIKAGNV-ALKIHNVTVFENGRYHCY--FQ
-E-GR--SYEEA-FID------L--K-VA-----SMGSDP-----------------FI-
------KIIGYEYG-WI-Q---L--ECTSSGWYPQPWVEWRNLTE-HTIPS-L-------
------E-------------------EH-LAPSEDGMFVVNLSVVIT-----D--HTIV-
KVFC-SIKNPL-LSQ-ELLTM-------MYIP-DPTT-----------------------
------------------------------------------------------------
------------------------------------------------------------
---PGPEKV-S----------------T----WMV-ALVAL-LAT------GLFITCSFY
L-----YFIWNRH----RRKK--------TLFIEKEI--ECEEKEKEYD-----------
------------ERGQ--EHM----------GKEGS-SN-LTGWR---RTQLHA----VV
KGEK--------------------------------------------------------
------------------------------------------------------------
-----------------------------AMIDHKTESGTLSLADVT---L--D-QNTAH
PELY----------LS-----WNLRSVIRGNT----R--QD-L------------PDN--
PERFDCRPCVL-----------GHESFT---SGRHY---WE-VE-V------SDVMVWAL
GVCRENSE-R--K-GE--------------------------------------------
---------------ALLIPQNGFWVIELF-----------GNRYQALTSP-D-----IL
---------------------------------LPLPEQLH---RVGIFLDYEAGDVSFY
NMIGRSH--IYTCPRTSF-S-GPLRPFFRLGSDD--------NPLVIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPV------AFCTSA-----HQPHLLV-----
-LVLSLPV-------------------------------------------LGSAQ-FSV
--------M-GPA-EPILAMVGENTTLHCYLLPEKNAEDM-EVRWLRSQL-S---P-AVL
VYKSRRERLEE----QMEVYRGRTTF-LSADINKGRV-ALAISNVTAHDNGVYRCY--FQ
-E-G--QSYEQA-VVR------L--V-VA-----ALGSKP-----------------LI-
------ELTALEDG-GI-R---L--ECTSTGWYPEPVALWRDPHG-EVTPAWE-------
--------------------------EA-YTADMDGLFAVSTVVIIR-----D--YSVR-
NMTC-SVNSSR-LDQ-ELESV-------VFIP-ESLTP-------GPPLWLVATAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-PPALILL-----VSG--T
I-----CFVKKLHEGKKA-LSW--------EKEVEYEKEE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----LQT-------------------------------SSSTADVV---L--D-PDTAH
PELF----------LS-----EDLRSVRR--GTSR----QT-V------------PNN--
PERFDCQPCVL-----------GQES FS---SG RHY---WE-ME-V------ENVMVWSI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLIPENGFWTLEMF-----------GNQYRALSSPEK------V
---------------------------------LPVKECLR---RVAVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-GPVRPFFRLGSDDSP-------L-FIC-PVF-KGAQGVT
VPE--------GGLVLYR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------EKMVGSLDF----------------SLPRDL--FS
ILLLQVSI---WGS----------------------------------------DS-FTV
--------L-APS-EPIVALLGADTALPCRVAPAMSAEDM-ELRWFRSRF-A---D-AVY
AYENRVEQTEQ----QLVDFRGRAEL-VKDHIAEGRV-AVRIRSVRVSDNGMYTCF--FK
-K-G--NDFEEA-TLE------L--K-VI-----GLGSGP-----------------RI-
------FMVDTEDG-GI-R---L--KCTGKRWFPQPEVQWKDVTG-EKIPS-L-------
------S-------------------ED-KTQDDDGLFQIEAFLVVR-----D--SSWR-
EVSC-TMKNPF-FGQ-EQVET-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKV-AFSLT-FLL-----LGIFIGAV--
V-----FLTWKEQQGRKRVQE--------A----QKE-KEKESQAKG-------------
------------------KTEGDLA-----FSELLE--KE-LDWR---KVAAQC----KR
TM----------------------------------------------------------
------------------------------------------------------------
---------ALASESFQKK------VFVPAV-------------AVT---L--D-PDTAH
TKLI----------LS-----EGRTHVSSKENVS--Q-NHD-G------------PTQ--
-QEQESIFSVL-----------GQNCFT---AGRHY---WE-AE-VKVGTAGGPGTRWAL
GVCSDTVK-R--E-GW--------------------------------------------
---------------FVESPEKNFWVVA-Y--K--------KEEIGVLTFQS------EP
---------------------------------LSLGQCPD---RIGVFLDWEAGDVSFY
NMVDGSH--IYSFTGIQF-C-GILRPYFSLQGPG-T-------SVAIC-PAS-DHTENCP
DSSP----KTSVTHLR--------------------------------------------
-SS-DMGVPQEANS---LLPP---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------G-FFV
--------T-GPL-DPIVAVLGGDTELPCHLFPPISAEDM-ELRWFRSNF-------AVF
IYQNRVEQNEG----QMARYAGRTSL-VSDFLAQGQA-AVRIQRVQVSDNGLYTCF--FR
-K-G--GFYEEA-SLE------L--K-VA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDLSG-EKFPA---------
---------------------------P-RPTARTGLFSVEVALVVR-----D--SSAG-
NVTC-SVLNTV-LDQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKL-AFLVS-LTV-----LMALLLGA--
G-----YYTWREEL----------------------------------------------
----------------R----TELG-----WRKSAY--LA-XXXX---XXX---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------XX--X-----------------------
--XXXXXXXXL-----------GQKEFT---SGRHY---WE-VD-IEDTD------EWTL
GIYEKPT-----E-RW--------------------------------------------
---------------VTQPSKKKFSVLE-K--K--------GREYRALTCSPQ-------
-------------------------------------KFSEPLRKVVIFLDYEDSDISFY
NMTDRTH--IFSFTQANF-S-ESLYPYFKLKS---M-------ELSIC-TIL-SDL----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------TFLLLNFHGC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GSH-GPILAMVGEDADLPCHLFPTMSTETM-KLRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSALYRGRTSI-LRDDVTAGKV-ALRIH-VTASDSRKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VADEP-PALGSDL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGCNTRGEDILV-------------------
------V-------------------EAPVVADG-----VAASVIMR-----G--RSRE-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---LRST--Q----------------P----WIA-ALEET-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREQEMKEMGYAATK-------------
----------------QEIS---------LRGKNKT-T---DL---------FL------
------------------------------------------------------------
------------------------------------------------------------
----I---CVS--------------------FLSEWKMAFFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVP-----------G----------RHY---WE-VE-V------GDRKEWNI
GVCSKNVQ-R---KVW--------------------------------------------
---------------VKMTPENGYWTIGLT--D--------GNKYRALTEA-R-----NN
---------------------------------LKLPEPPK---KVGIFLDHETGDISFY
NATDGSH--IYTFPHTTF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--H--D-----------------------LVPD--------HSLETPVA------PGL
ANENGEPRAEATSL---LLPAHPGV-DGLPLH--------N-TNQNHKATGTH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSS-----G-----SWLCSCLI-----T
LIFLQLPA-------------------------------------------QGS-V-C--
--------T-GYVDKFYLVPLGGTAELLCPLVLWPGLELE-EVRWLHSPHPQ-HSK-AVY
VFQNGTDWDDG----QTPEYKGRTAL-VRDI-QEGKI-ILKIFNVQLEDRGQYSCQ--IQ
-I-S--NMSREA-NVT------L-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------QV----
------------------------------------------------------------
-----------------------------------------------------AAPSPGK
I---S-----S---------------------ST-VAFAVI-LCA-----LGLLITAG--
I-----YLIWKERKSKEKLLYE--QVVEVE-NLLSDHEEEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKFRNELRL-----------KRDAANSGWRRARLHFXXXX---X--X-XXXXX
XXXX----------XX-----XXXXXXXXXXX----X--XX-X------------XXX--
XXXXXXXXXXX-----------XXDCFT---AGCHY---WE-VY-V------GDKTKWI-
GVCSE-VT-R--K-GK--------------------------------------------
---------------VVASPSNGHWLVRQS----------RENHYAALTSPQI------S
---------------------------------LRFREPPR---CVGVFLDYEAGVISFF
NVNDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEP-QKPEELT
VPKP---------------------------------------------------EEKD-
-GANGDMSLTVNPS---LLPPPSGEL--FTLE---DMIVTWPSDLSPALQELKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------PAGSQ-FSV
--------K-GPA-EPIVVSLGADATLPCQLSPEQSAAGM-HIRWYRAQI-S---P-AVL
VFQDGQEHSEE----QMLEYRGRTQL-VTDSIDTGSV-TLLIQNVRASDDGQYRCY--FR
-D-G--DISREA-TVE------L--N-VE-----GLGTVP-----------------RV-
------HMTGPEDG-GI-R---V--LCSSEGWFPKPTVQWRDSAG-GKLLS-P-------
------P-------------------ES-QTQDGDGLFQVEASLVVK-----D--SSLG-
NVTC-SIQNPL-SRQ-ELASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--S----------------P----WKA-ALAWT-VPV-----LSLLLVGI--
S-----YIGWRERQVKSKGNT--------GDQAFCRA-RSLVQRRKPCGFPQNS------
------------QS-----LKKELE-----ERKELY--LQ--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQA-------------AVVT---I--Y-NERLS
ENNS----------GT-----EGK------ENHR--KE----------------------
----SQNLISV-----------EQRYFT---SGRHY---WE-VD-IKDAD------EWTL
GIFEENTV-K--N-AS--------------------------------------------
---------------SSEPSKKKFRVLE-K--K--------RGTYRALGYCFQDIFKEET
---------------------------------LHIEKDPQ---KIVIFLDYGDSDVSFY
DIDSGDH--IFSFTEPSF-S-GSLYPYFIHKPVE-F-------SVCAQ-PTD--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSC-----G-----SRLSSCLI-----T
LVFLRLPG-------------------------------------------LL-S--R--
--------T-GDAGTFHLAPLGGTAELLCPVSLWPVTEPK-EVRWLRSPHPQ-RSQ-VVH
VFRDKKAWEEE----QMPEYKGRTAL-VRDP-QEGSV-TLQIRDVRLEDRGPYRCL--IQ
-I-G--NLSRED-TVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------LA-VALAVI-LSV-----LGLLIMVC--
L-----WLIWKQRRSKEKLLYE--QVMEVE-NLLSDHAREK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELRL-----------KRAAANSGWRRARLHFVV VT---L--D-PDTAH
PKLI----------LS-----EDRKCVRLGDR----R--QP-V------------PDN--
PERFDFVVSVL-----------GTEY FT---AGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------DGNKHEALTSPQI------S
---------------------------------FRLKEPPQ---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTDSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QKSKESV
VPKP---------------------------------------------------EGKR-
-HANGDVSLKVNPS---LLPAPDMEL--FSLR---DMTLSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKLK--FS---YLS--------GYC------GY
LLFLQ--V------------------------------------------MMSSEK-LMV
--------T-TPT-RHVLARVGGHAEFSCQVTPLHSVEYM-EVRLFKSGH-S---Q-PVY
LYRGGHGVNGE----AAPEYVNRTEF-VKDAIGKGRV-ALRIHNISISDDGLYQCL--FS
-DDS--GFIDVA-SMN------L--S-VT-----AVGLET-----------------QI-
------HVQAPDAD-GV-M---V--ECNSGGWFPQPQMEWRDSRG-KTLPP-S-------
------S-------------------KS-YSQDEARFFHMKMTL-LT-----N--RSQG-
SIIC-CIFNPV-TGE-EKQTS-------VFLA-NDLFN-------QDGIWMTFLVSIACI
M--LFLFVMYFICFYKKHGFG-------------------------------------RL
HRCLSKLNSWPIQILS--LL---TCALVLFAVYLPFR---------------IRVSLSDP
Q---FPLY--N--------------------SWI-FELIS-VIIF-LLI-FFVLPIIV--
L-----ILIQLRNKK-------------------NTL--------DS-------------
------------------------------------------------------------
-------------QTVH-----EGTK----------------------------------
-KSWEQK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVGVPGCA-----A---------GFLLPV----
-LLLQVPS---WCS--------------------------------------AAPG-FSV
--------K-GPA-EPVMVLLGADATLPCQLSPEQSTAHM-HIRWYRAQL-S---P-AVL
VYKNGQEQGGE----QMLEYRGRTEL-VGDSIGKGTM-ALLIHHVRASDNGQYRCQ--FK
-D-G--QISQEA-TVE------L--H-VI-----GLGSDP-----------------HV-
------HMTGPEDG-GI-R---V--LCSSGGWFPNPRVQWSDKAG-VKLLS-H-------
------S-------------------ES-LTQDGDGLFHVEASLVVM-----D--SSLG-
NVTC-SVQNPL-SGQ-EKEST-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRM--S----------------P----WKA-ALAGT-LPV-----LVLLLIGI--
S-----YTGWREHLAKERDLK--------KRDDESDE-RDQMKCEKKKA-LNAK------
------------AN-----LEAELE-----RRKNLY--AA--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EHFNL-------------APVT---L--H-LKTFL
QNNS----------DT-----ERK------ETLR--EETQD-L------------SLSNK
--QGNGNLITL-----------KVEGFM---SGRYY---WE-VD-IEDTN------EWTL
GIHEEPTD-S--K-----------------------------------------------
--------------------GLQFRILE-K--K--------GCDYRALACCLKKISLAEH
---------------------------------LLIEKCPQ---KIVIFLDYEDGDISFY
NMTDGSH--IFSFTQLSF-S-GSLYPYFKLESME-L-------SPSA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLRLSV-------------------------------------------HV-SG-R--
--------A-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-AVH
VFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAV---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPPDLGPALRELKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ME-----------TMEVLLCRLF--------VV
LYLLP-VI------------------------------------------TPSSEQ-FRV
--------N-GLK-GPILAPFGGEVELSCQLSPPQSAQHM-EIRWFRNRY-T---Q-PIY
LYKAGKDRYGE----MTPMYVERTEL-LKDAIGEGKV-TLKIFNVGVDDDGQYHCF--FR
-D-G--DFSEED-ITE------V--K-VT-----ATSSNI-----------------QI-
------LVLPSNID-DL-R---V--ECNSRGWFPQPQMEWRDSQG-KVLPP-A-------
------S-------------------KS-HSQDTDKLFNMKMTLFLS-----N--THPG-
DVTC-YLRNPL-TGQ-EEKIN-------IVLP-GEICV-------FVLHMTAIVT-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------M-FFG---CCFHC-----PMLAAVLY----
SFVFHIHE-------------------------------------------LQSAP-FSV
--------Q-GPP-DPVAVAVGQDVVLQCRLFPEQSTQDM-EVTWFRDQF-T---P-FVH
RYRDGQDQYGD----QELRYQGRTEM----RLANGSV-SLRILRVQLSDKGCYTCF--VR
-T-D--LGYDEA-VVE------L--K-VT-----ASGSAP-----------------LI-
------ALQRYQDG-GI-R---V--ACRSAGWFPQPQLLWRDPHG-QWLPS-L-------
------S-------------------EN-VTQDGDGLYTAESVLVLA-----S--GVSQ-
ELAC-VVRAAL-HNQ-EKES----A---FSIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FQNA--R----------------P----WKI-ALSVV-LVA-----VVALSIVA--
V-----YLLKMKGKYEKKIGK--------LHFAMSWKS-----------IILRMGW----
-----W-----RQRGTEQPQKIK-------------------------------------
------------------------------------------------------------
---------------------E--------------------------------------
--------QISEMTKW-RRAFARSKRTSREIG------------ARR---V--G-APPTC
CRTAVPVLHGSVPHRR-----NNHRGWRRLEE----Q--QD-L------------PSQ--
PGSFPGAKKTM-----------PTPAKQ---PGNHFRSSDH-HE-C--ES---DGGGWTV
GVSREDVR-R--K-GE--------------------------------------------
---------------IEFSPEEGIWAVG-Q--W--------AGQFQALTSPQR-----TL
---------------------------------LPDVHTPT---RVRVALDYELG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------ACVLRCF-----Y--------VCSSL------
-----TLV---SVS---------------------------------------TEE-FTV
--------I-APP-DPIVAVLGGEVLLPCRVSPAMSAEDM-ELRWFRSKF-S---E-AVF
IYQDRLEQKEE----QMAPYAGRTSL-VRDLLIQGEA-AVRIQNVSVSDNGLYTCF--FR
-K-G--GFYEEA-SLE------L--K-VA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDLSG-EKFLA-F-------
------S-------------------EA-HTQDTEGLFSVEAALVVR-----D--SSVG-
NVTC-SILNPV-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFSVS-LTV-----LVILLLGA--
G-----CYTKRQHSMKMQ------------------T-SEQDRQTKEEL-LKDA------
------------G---K----EELE-----RRKSAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EEFQEW-------------PVT---L--D-PKT--
-------------------------SVTLKT-SC--V-----------------------
--NAADKCSVL-----------GFEGIT---SGRCY---WE-VE-IRDGD-QS---EWFL
GVCGEGVN-R--K-GW--------------------------------------------
---------------YVESPGKEFWAVG-R--F--------ERGYCVCTVPQI------L
---------------------------------VSLMQAPHPRLRVGVFLDHQEGDISFY
NMTDGSH--IFSFPQASF-S-GTLFPYFMISSGN-V-------SLTVC-S----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
LMPAHLLS-------------------------------------------LGKAD-FSV
--------F-APD-KPLLAVVGEEVDLPCHLSLNISAEDM-ELRWYRDQP-S---P-AMH
LHKNGIDVQDE----QMAEYQGRTTF-LSTRLAQGQA-AVRIHNVTALDNGTFHCN--FK
-D-G--IMSAET-TLW------L--R-VA-----GLGSEP-----------------KI-
------QVGPGQSE-GV-W---A--QCTSEGWYPEPQVEWRDLGG-QSLPS-V-------
------T-------------------NL-SASPTTGLFSVVSNVTLL-----D--RDVE-
GLSC-SIISSL-LQR-RKVA----K---SYLP-AQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
L---SRSL--P----------------S--MTWRT-VLPLI-LTV-----AGLAIAGA--
T-----CLFQKFEKKKRFQKE--------EKERKKRK-KERKKE-EEEEEEEEEE---RK
KE----------------------------------------------------------
--------------------RKK--ER-------KKEQ----------------------
------------------------------------------------------------
------LAMSLAVEEW-K-------------------VLGSPPFSPS---L--D-PDTAS
PKLA----------LS-----EDGKSVRRLFV----D--QE-L------------PDI--
PSRFDQDPCVL-----------AREQ FS---A GKYY---WV-VQ-V------GHRKAWNL
GVCLDSLD-P--K-GR--------------------------------------------
---------------IPKAPTNGLWALE-L--Y--------KETFWALTFP-R-----VR
---------------------------------LYPSEPLH---QVGILLDCEAGRVSFY
NVGSGSL--IYTFSGLSF-S-VPLRPFFCLWTHDPN-------PLTIC-TEC-QDLEA--
--LG----S------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSRP-HRGD-ATLPSF----LVT---FIF--LQ
LLPAG----------------------------------------------NGKSD-FCV
--------L-GPP-DPLLALVGQDKELPCKLSPNISAEGM-ELRWYRDQP-S---P-AVH
VHKDGEDVYEE----QMEDYRGRTTF-VGSHMVRGEV-AVRIRNVTVSDNGTYHCV--FK
-E-H--TSHSQA-TLW------L--K-VA-----GLGSSP-----------------RI-
------HVTGTQDK-SI-R---A--ECTSSGWFPEPKVEWLDLRG-EPVPA-E-------
------T-------------------HF-SASASTGLFAVVSTVTPQ-----D--RAVE-
GLTC-SISNPL-LPE-KKVA----E---TYLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FRRP--P----------------S--TERGP-ALPLI-LTA-----LGLVTAAI--
A-----CAFGRSHKEDKSEEE---------EAETG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TS-A-------------------EAEPSHAS LS---L--D-PETGS
PKLM----------VS-----EDRKSVKRLLF----D--QD-L------------SPS--
SKRFDQDPCIL-----------AQER FD---AG RHY---WE-VE-V------GGRRAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TR
---------------------------------LSPPQPLW---RVGIFLDFEAGEISFH
NAADGSQ--IYVFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-REAEEDT
ESSG----G------------------------PD--------LPGDSR-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--ML
ILVLSFY-------------------------------------------KLASGQ-WQV
--------T-GPG-KFVQASVGEDAVFSCSLFPETSAEAM-EVRFFRNQL-H---A-VVH
LYRDGEDWESK----QMPQYRGRTEL-VKDSIAGGHV-SLRLKNITPSDIGLYGCW--FS
SQ----IYDEEA-TWE------L--R-VA-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTAKWKGPQG-QDLSSDS-------
---------------------------R-ANADGHSLYDVEISTIVQ-----E--N-AG-
SILC-SIHLAE-QSR-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLLC---GALCVVVMGM--
-----TIVFFKSKGK---KLQ--------DKL----------------------------
------------------------------------------AWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTQRKA----L--QD-V------------PYS--
EKRFT-RKSVV-----------ASQGFQ---AGKHY---WE-VD-V------GQNVGWCV
GVCRDY------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------EGGTI-FF
NTNGQSF--I-HTMTCQ-EG-L-MRPYIQHVM-D-E---KNGTPIFIC-PVS-WGS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MVL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPD-KPVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQF-S---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIVEGRI-SLRLENITVLDAGLYGCW--IS
SQ----SYYQEA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SIMGYVDR-DI-Q---L--LCQSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNTDMHGLFDVEISLTVQ-----E--N-AG-
SISC-FMQHAH-LSR-EVESR-------VQIG-DTFFKP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQGK----ER--------EAWA---------------------------
---------------------G--AL----------------FMV---PAGT--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------GSEMLPHPAASLPLV---L--A-SRGPG
PKKE----------TP-----G-GIGLEKKAR----P--GR-I------------ERR--
PETRS-GGDSG-----------SRDGSP---AALRF------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ME--------AFPVSS-QLKYLI---FFF--FQ
F-----PM-------------------------------------------LYSAH-FDV
--------I-GPV-KPILVMVGEDIDLPCHLSPNISAENM-ELRWYRNKI-S---P-AVY
VYQKEKDQKGE----QIKEYQGRTTF-VRDNITEGNV-AVTIHNVRASDDGQYRCF--FK
-D-D--QMYEEA-IIE------L--K-VA-----SLGSDP-----------------HI-
------HMEAYGDE-GI-L---L--ECTSVGWYPVPQVQWKDLRG-EILPL-L-------
------S-------------------VS-QTSNGDGLITVEASVVIR-----D--NSVR-
SASC-FIHNPL-LNL-EKVV----R---ISIP-GP-------------------------
------------------------------------------------------------
------------------------------------------------------------
F---FSTL----------------------SPWMM-SMAVI-LXX-----XXXXXXXX--
X-----XXXXXXXXXXXXXXX--------XXXXXXXX--------XX--X---XX---XX
XX-X--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------XX-----XXX-X-------------------XXXXXXXXXX---X--X-XXXXX
XXXX----------XX-----XXXXXXXXXXX----X--XX-X------------XXX--
XXXXXXX---X-----------X--------XXXXX---XX-XX-X------XXXXXXXX
XXXXXXXX-X--X-XX--------------------------------------------
---------------XXXXXXXXXXXXX-X--X--------XXGYWALTPL-R-----TP
---------------------------------LPLTGPPR---RLGVFLDYESGHISFY
DMTNGSH--IYTFPQASF-S-GTLRPFFCLWSCGKK-------PLTIC-PIF-NGPDEIT
VIPN----A------------------------PV--------PSKESLVSPT---SERS
TPGDTGT-LRSNSK---LFSIQPKNG--ASL-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----VPGSLLL-----
LLLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILTTVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-STPAADGLFMVTTAVIIR-----D--KSVR-
NMSC-SINDTL-LGQ-KKESV-------IFIP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFNNEPCVL-----------GRES FT---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVK-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KEQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-IGANGVT
VPE--------EGLTLHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---VSL-------------------DFSRIA-------LLSSS------------LSLGL
LLLLQPGK------------------------------------------LN-SEE-VKV
--------L-GPE-PSVVAHVGEDVEFQCHLSPYLDAEDM-EIRWFRSQV-S---E-VVH
LYQHRQELNHL----QMTQFQNRTKL-LKDDITVGSV-YLQLHNLMPSDNGPYGCH--FL
-T-S--NFSSEA-VWE------L--E-VA-----GIGSDV-----------------HI-
------SLEGFKNG-DI-Q---L--SCSSHGWYPKPKVQWRDHQG-KCLPP-K-------
------A-------------------EA-IVQNAQGLFSLDTSVIVP-----R--GAHR-
NVSC-SIQNPL-LNE-KKECV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DE
F---LPRT--S----------------P----WKG-AFLGM-LVG-LPLLLAGLTTLG--
V-----YFFQKQRKFQEKFKK--------QKEN-EQA-----------------------
-------------------NQTAL----DWRRSEGQ-----AEWR---AAQQYA----VE
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----DDGKSVCSL---GTTP--GW-K------------PCD--
PQRFSDQTCVL-----------SHQRFS---TGRHY---WE-VH-X------XXXXXXXX
XXXXXXXXXX--X-XX--------------------------------------------
---------------XXXXXXXXXXX-XXX--X--------XXXXXXXXXX-X------X
--------------------------------XXXXXXXXX---XXGF--SLYGSGL-CF
LKSSQWS--IFTFSDTF--S-GQLCAYLRPRAPVGV---DRQGALTIC-PLP-GKGRRIP
EED------SNDCWLQ----------------------------PY-EPD----------
------PYLG-------VW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDVTSWTVLTVS-VAIVSLFGI
LIMRPSEKFTVTGSAEP-ILAKLNEDVILPCHLSPKMSAEHMEVVWFRSQFSDAV-YVYR
NGKAQDGEQAMEYKGRTELVKD-TIAEGYVALRIRSVRLSDNGQYWCRFQENNEYGEARS
EVIVTT------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------SVSTF-------
-----------------------------------------------------STAMRKV
--------I-GLT-QSIITRVGEDVLLPCHLFPEMNAQNM-EVGWIRSQF-S---D-IVY
MYRDGKDQEEE----QMVKFKGRTVF-IKDAITNGNV-ALKIRNIRVSDGGQYQCY--FE
-K---NQVFQRA-VLE------I--Q-VQ-----GKVLN---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MWMAVFP
---N----------------------------------SLP---------GCL-----LT
LMLLRLPT------------------------------------------LDA-AP-FEV
--------L-GPL-EPILALVGEDSELPCYLSPSVSAEHM-ELRWFRNTF-S---P-AVL
VYQDGQEQEGE----QMPEYQGRVTL-VTDNITAGHA-ALRIHGIRAFDEGVYGCS--FK
-D-DQ--AHREA-FLQ------L--R-VA-----ALGSDP-----------------HI-
------SVEVQDSG-EI-R---L--ECTSVGWYPEPQVQWRTPAG-EKFLS-T-------
------S-------------------ES-RSPDQEGLFTVATSMIIR-----D--TSLE-
TVSC-CIRNLL-LGQ-QKEVG-------ISTS-APS------------------------
------------------------------------------------------------
------------------------------------------------------------
--------D-A----------------I----WSS-LM------V-----AVLMGLTG--
V-----FVTWQLYRKYVKKKT--------KNETS--------------------------
-------------------------------------PI---EWK---LARSH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PGTAH
PHLI----------LS-----EDSKSVRLEDS----R--QK-L------------SEN--
PDRFDSWPCVL-----------GKKP FT---SG RYY---WE-VE-V------GDRTDWLL
GVCREDVM-K--K-GF--------------------------------------------
---------------ILMSPKNGFWVVELS-----------EKGYWALAPL-R-----VL
---------------------------------LSLPEAPH---QIGIFVDYESGAVSFY
SVNDGSH--IYSFTKVSF-S-GPLRPIFCLWSCD-------KKPLTIC-PVAVDGPAEVT
VVPD----A------------------------QT--------HQR--LLP---PMGEDS
GSGVTNN---QPF-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVKSP
---VS-------------------LDWFQRV-------PQPSS------LVFLIHL----
LLFLQPRE------------------------------------------SN-SEE-VKV
--------I-GPG-ESILANVGEEVEFPCHLSPYRDAEHM-EILWFRSQA-S---D-VVH
LYQDRRELPGR----QMAQFQNRTTL-IKDEILDGAV-ILQLQDVLPADQGSYGCR--FL
-S-RDDSFSGEA-VWE------L--E-VA-----GMGSDP-----------------HI-
------SLEGFKKG-GI-Q---L--RCSSSGWYPKPQAQWRGHLG-QCLPP-E-------
------F-------------------EA-ITQDARGLFSLETSVVVQ-----G--GAHS-
NVSC-SIQNPV-LLQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------PSPGR
I---S-----S---------------------SD-VALAVT-LPI-----LIFLIIVG--
I-----YFIWKQRKSKEKLLYE--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KKAAANSGWRRARLHFXXXX---X--X-XXXXX
XXXX----------XX-----EDRRCVRLGDR----K--QP-V------------PD---
PQRFDFVVSVL-----------GSEYFT---AGCHY---WE-VF-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDGSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QKSEESL
VSKP---------------------------------------------------KGKG-
-HANGDVSLKVNPS---LLPPQDPEL-----G---DMILSWPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
-PLLSLCA-------------------------------------------LVSAQ-LTV
--------V-GPT-DPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRQRTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSSDEA-ILR------L--V-VA-----GLGSEP-----------------LV-
------EMRGHEDG-GI-L---L--ACISRGWYPKPLTVWRDPFG-EVVPSLK-------
--------------------------ED-NTPDTDGLFMVTTAVIIR-----D--RSVR-
HMSC-SVNNTL-LSQ-KKESV-------IFIPGETFMP-------SVSPCVVALPV----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------------------------
--------------EKKIL-LG--------EKEFEREMREIAIKDLE-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KE----KEL----------------------------------------
-QI---KG----KRGW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GAFR----QS-V------------PDN--
PERFHSQPCVL-----------SRES FT---SG KHY---WE-VE-V------ENVLEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------FLLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RLGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSVF-S-VPVRPFFRLGSYDSP-------I-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHHSPQDQFPGLTAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVGSPGCS-----P-------A-GFLLPL----
-LLLEVST---WYS--------------------------------------AVSG-FSV
--------K-GPV-EPIMVLLGANATLPCQLSPEQSAADM-HIRWYRTQF-S---P-AVF
VYQNGQEQGGE----QMLEYHGRTEL-VRDSINRGGV-ALLIQHVRASDHGQYQCH--FK
-D-G--QSSQEA-IVE------L--H-VI-----GLGSVP-----------------HV-
------HMMGPEDG-GI-R---V--LCSSDGWFPKPKVQWNDMLG-VNLQS-L-------
------S-------------------ES-QTQDEDGLFHVEASLVVM-----D--SSLG-
NVTC-SIQNPL-SGQ-EKVSC-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKM--D----------------P----WKA-ALAGT-VPV-----LMLLLIGI--
S-----YTGWREHQAKEKEVK--------KKKRELNE-RDQMKNEKEMA-QKAT------
------------EK-----LKAELE-----QRKALY--LE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------KHFQC-------------ANVT---V--N-MEIFH
QNNS----------DS-----ERN------ENFR--VETQD-L------------SLSDK
--QGDCNLIIL-----------NQEDFT---SGKHY---WE-VN-IKDID------EWTL
GVYEKLTD-K--S-EL--------------------------------------------
---------------STDLQNKKFRVLE-K--K--------GSEYRTLTCCPPNISQDDC
---------------------------------LQIGKCPQ---KIVIFLDYEDNDISFY
DMTEGTH--IFSFTQTNF-S-GSVYPYFNLKCME-H-------SHLC-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------VS---------------------------------------TEE-FFV
--------I-GPS-DPIVATLGGDITLPCRVSPTMSVENM-ELRWFRSKF-S---E-VVF
VYQNQREQNEE----QMAQYAGRTSL-VRDLLTQGEA-AVQIHKVQASDNGLYTCF--FR
-K-G--GFYEEA-SLE------L--K-VA-----GVGSAP-----------------QV-
------YIKGLEED-GI-R---V--VCMASGWFPKPQVQWRDLSG-EKFLA-F-------
------S-------------------EA-HAQDEEGLFSVEASLVVR-----D--SSAG-
NVTC-SILNPI-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKL-AFMVS-LTV-----LVLLLLGA--
G-----YCTKRERSAKFQEMQ--------KQDDLRQA-KKEDCQTKEEA-LKAI------
------------DE-LQ----ADLS-----WRKSVY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQAW-------------SVT---L--D-PGSAH
PSLA----------VS-----HEKMSLTWKD-TC--V-----------------------
--DSEGSCSIL-----------GLEGIT---SGRCY---WE-VV-VRSGD-RS---EWAL
GVCSKDVK-R--K-GW--------------------------------------------
---------------YRECPEKGFWIVG-H--Y--------EKNYCACTIPQT------L
---------------------------------LFLRQVPH---RVGVFVDYNEGDVSFY
NMTDGSH--IFSFPQASF-S-GMLFPYFTLKSGD-V-------SLTI-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTV---FPN-SCLPRC------------L--LT
FFLLQLPK-------------------------------------------LDSAY-FDV
--------I-GPQ-EPILALVGEDAELPCHLSPNVSAEHM-ELRWFRRKV-S---P-AVL
VYRAGVGQEGE----QMAEYRGRATL-VRDSITAGRV-AVRIHGVRASDDGEYRCF--FR
-E-N--ETYEQA-KVQ------L--K-VA-----XXXXXX-----------------XX-
------XXXXXXXX-XX-X---X--XXXXXXXXXXXXXXXXXXXX-XXXXX-X-------
------X-------------------XX-XXXXXXXXXXXXXXXXXXXXXXXX--XXXX-
XXXX-XXXXXX-XXX-XXXX----X---PVFP-R--------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------L--THWMV-AVAVL-LVIL-----GLLTIGS--
I-----FFTWRLYRERSRERK--------NELNPKEK-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------LLEELKR-K-------------------KAALHAXXXX---X--X-XXXXX
XXXX----------XX-----XXXXXXXXXXX----X--XX-X------------XXX--
XXXXXXXXXXX-----------XXETFT---SGKHY---WE-VE-V------GNRTDWAI
GVCRDNVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVE-L--Y--------GNGYWALAPL-R-----TP
---------------------------------LPSVGAPR---RIGIFLNYDSGDISFY
NMSDGSL--MYAFRTVSF-S-GPLRPFFCLWSCGKK-------PLTIC-PVT-HGPEEVT
VVSD----A------------------------QN--------LSKEIPLSPI---GENS
PSGDTDT---LHSK---LITGQPSQG--TR------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLIL-----
LLLLRLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GVVPALK-------
--------------------------EV-LTPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SINDTL-LNQ-KKESV-------IFIP-ESFMP-------SMSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EMESERETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-EE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDRP-------I-FIC-PAL-IGASGVT
VPE--------EGLTLHRVRTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

MERPWPDALFLEKAAFQALTCLWNLLCGRRVHLGPGRMVEFPGYSLSGG---LASFFFIL
LSMKQSDDFRVTGSAHP-ILAMVGEDALLTCQLLPKRTAKHMEVRWYRLEPSTPV-FLYR
DGDEVTEIQMEEYRGRVEWIED-GVTEGSVALKIHSLRPSDHGQYWCHFKDGN YLAETSL
LLQVASLGSDPYIHMD---------GS---VE---------------------------S
GLQLVCTAKGWF----------PEPQ---VS---WKDIKGENL-----------------
-LAFSNYNFQDED--------------------------------G------------SF
YVESTLVVRDAS----------------------------------TEAVSCFIHN----
PSLTEEKG------------------------------SDI--SIPEK-LQAELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCSLAPRTDARSM-EVRWVRSHR-H---P-AVY
VYTDGAHVAGE----QMAEYRGRTAL-LSDAISEGRL-TLQINDARISDDGKYCCL--FE
-K---DGVYQEA-DLD------L--K-II-----GLGSSP-----------------QI-
------SMEGPKDG-EV-K---L--KCTSEGWFPRPHVQWRDMEG-NPIPSFS-------
--------------------------QD-LTQGSQGLFHVEAFLLVT-----N--SSVV-
NVTC-SISSPL-LGE-EKKTT-------FYTS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------I
Y---------L---------------------RNILRIWGL--------LLLLLLVGV--
V-----GLIWRKSCRKVNETL--------D-SKTAHPER---------------------
---------------------------------ILSE-G--NKLV---AYR---------
-QSS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------S-Q----
---M----------SC-----NN-------------------------------------
------------------------VK-----ASFAS---WD-GRGL---SQERGTE----
------RR-R--L-GI--------------------------------------------
---------------GRDRP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------VTLPCSVSPAMNVKNM-ELRWFRSKF-S---E-AVF
IYQNQQEQR-------------WTSL-VKEFLTWGEA-AVRIHNVQAFDNGLYTCF--FR
-K-G--SFCESA-SLE------L--K-VA-----GVGSVP-----------------QV-
------HIQGPEED-GV-R---V--VCKASGWFPKPHVRWKALSG-EKFLT-F-------
------S-------------------ET-HAQDSEGLFSVEATVVVR-----D--SSSG-
NVTC-SLLNPI-LSQ-EKAMA-------IIIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------D
F---FPRT--S----------------P----WMS-AFMVI-LTL-----LMLLLLGT--
A-----CYTKREYTAKCREMQ--------EWKKLHRE-NL-------------S------
------------DE-LQ----EDLA-----WRKSVY--L--AVWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VSVT---L--D-PKSAH
PRLA----------VS-----DEKTSVTLKDTAE--D-----------------------
--P-TILFSIL-----------GQKSIT---SGRCS---WV-VE-IRNED-KS---EWSL
GVCRGDVE-R--K-SL--------------------------------------------
---------------HLESPEKGIWAVG-R--Y--------LESYYACSIFRI------L
---------------------------------LSCRQVPH---RVGVFLDLKEWDVSFY
NMTDDSH--MFSFPLASS-S-GTLFPYFMLRSGD-M-------SLTIC-SVM-GGPAEIP
VPLN----N------------------------PP--------SSLEEPVSLSG-VGLKS
VS----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT---G---VL----------LC------VV
LHFLQ-MV------------------------------------------TQSSEK-FTV
--------T-GLQ-RPVLAPLGGNVELSCQLSPPQQAQHM-EIRWFRNRY-T---E-PVY
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLRIFKLTADDDGTYHCV--FK
-V-G--EFYEEH-ITE------V--K-AT-----ATSSDM-----------------YI-
------LMQPPNIK-GV-M---L--ECHSGGWFPQPHMEWRDNKG-NIIPA-T-------
------S-------------------KA-HSQDENKLFNMTMTLLIE-----A--SSHR-
SVTC-YLQNLL-THQ-EESIS-------IVLS-GELFS-------WKIVWIMILTTIGFM
MIA-FCMTYYVQQ-RLLYGSV---------------------------------------
---SEGKCHWLKSIMVLMFS---VIAVTGVMLILHLK---------------QRGLMEIN
----YECT--E-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLRLSV-------------------------------------------HV-SG-R--
--------A-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSRFPQ-HSQ-AVH
VFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAV---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFLA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPPDLGPALQELKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------SVSPS-------S---------------------
----DGIK------------------------------------------N-FLFE-VKV
--------V-GPG-EPILALVGEEVEFPCHLSPFLDAEHM-EIRWFRSRA-S---D-VVH
LYRERQELPGL----QMAQFQNRTKL-IKDDIVDGSV-VLQLHSVVPSDEGLFGCR--FL
-S-S--NFSSEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-SI-Q---L--RCSSSGWYPKPKAQWRDHQG-QCLPP-E-------
------S-------------------EA-IIQDAQGLFSLETSVVVK-----G--GAHS-
NVSF-SIHNLL-LSQ-KKELV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------P----WKR-AFLGT-LAA-LPLLLAVLGTPA--
L-----CFLQKQRRSQGRGLM--------FSP---------C--ALF---T---------
-----------------EKLQTEL------GKGGGQ-----T------GPRAAL----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-HASAH
PSLE----------VT-----EDGMSVSSR---GVAQ--GP-A------------PSD--
PQRFSEQKCVL-----------SRER FS---AG RHY---WE-VH-V------GCRSRWFL
GACLAAVP-R--T-GP--------------------------------------------
---------------ARLSPACGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RVGVLLDCGAGKLSFF
NVSDGSH--IFTFTDTF--P-DALCAYFRPRAHDGS---EHADPLTIC-RLP-ARGTAIP
EEE------DNDTWLQ----------------------------PY-DPS----------
-----APALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FTV
--------L-GPA-YPILAVVGEDATLRCHLSPEKNAEDM-EVRWFRTQF-S---P-AVF
VYKGRRERTDE----QMEQYRGRTTF-VSEAISEGSV-GLIIHNVTAHENGIYCCY--FQ
-E-G--RSYDEA-IMH------L--T-VT-----GLGSKP-----------------VI-
------EMKSPEDG-GI-R---L--ECTSAGWYPKPHAVWRGPHG-ETMPPLE-------
--------------------------EA-YTVSADGLFLVTMAVIIR-----D--HSVR-
NMSC-SVINTL-LDQ-EKETV-------IFIP-ESFIP----------------------
------------------------------------------------------------
------------------------------------------------------------
------RT--S----------------P----WMV-ALVVI-LPSL--LLL---IAG--S
I-----YLIKEL----------------------------------G-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KEKEC--Q-----------------------------------------
----T-KEQLQEELRW--------------------RRNLLHAADLL---R--D-PHFTH
PSLY----------LY-----EENYPLRF--EDRR----QK-S------------PDK--
LQRYXSWPCVM-----------GREAFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPLRT------P
---------------------------------LPLAGPPR---RVGVFLDYESGDIFFY
NMTDGSH--IYTFSKASF-S-GPLRPFFCLWSCGKK-------PLTIC-PVT-DGLEGVM
VVA--------DAKDISKEIPLSPMGEDSAS--GDIETLHSKLI----------------
-------------P---LQ---PSQ--GVP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVELPGYSLSGV---FASFFFML
LSMKQSDDFRVTGSAHP-ILAMVGEDALLTCQLLPKRTAMHMEVRWYRSEPSTPV-FLYR
DGDEVTEIQMEEYRGRVEWIED-GITEGSVSLKIHSLQPSDHGQYWCRVKDDN YLAETSL
LLQVASLGSDPYIHMD---------GS---VE---------------------------S
GLQ LVCTAKGWF----------PEPQ---VS---WQDIKGEKL-----------------
-LTFSNYNFQDED--------------------------------G------------LF
YVESTLVVRDAS----------------------------------TEAVSCFIHN----
PSLTE EKG------------------------------SDV--SIPEK-LQTEMAS-LKV
--------I-GPS-QPILVRVGEDIQLTCSLAPKTDAQSM-EVRWVRSHR-H---P-AVY
VYTDGARVAGE----QMAEYRGRTAL-LSDAISEGRL-TLQINDARTSDDGKYQCL--FE
-K---DGVYQEA-DLD------L--K-II-----GLGSSP-----------------QI-
------SMEGPKDG-EV-K---L--KCTSEGWFPQPQVQWRDMEG-NTIPSSS-------
--------------------------QD-LTQGSQGLFQVEAFLLVT-----N--SSIV-
NVTC-SISSPL-LGE-EKKTT-------FYAS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------I
Y---------S---------------------WNILLIWGL---------LLLLLVGV--
V-----GLIWRKNCRKGSSES--------F-LHPKESQQ---------------------
---------------------------------HLQG-E--HKDL---EKV---------
-LKS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------S-E----
---V----------RL-----RD-------------------------------------
------------------------TS-----E----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SD-FRV
--------L-GPP-DPLLATVGQDKELPCKLSPNISAEGM-ELRWYRDKP-S---S-AVH
VYKNGKDVYDE----QMTEYKGRTTF-NGNRVARGEA-AVKIHNVTMFDNGTYHCV--FK
-E-H--TSYDQA-TLW------L--K-VA-----GRGSSP-----------------RI-
------RVTNTQDK-GI-Q---A--ECTSAGWYPEPKVEWLDLKG-RPVPA-E-------
------T-------------------HF-SVSTSTGLLAVLSIATPQ-----D--RAVG-
GLTC-SISNPL-L PG-KVTE----T---YLL--GPVIP----------------------
------------------------------------------------------------
---------------------------------------------DA-----F-GIPLAP
L---SRRL--L----------------S--TEIGP-ALPLI-LTA-----LGLVSAAI--
A-----CAFGKCHTEEQKTSE--------EEEEPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AG-D-------------------EDELFHVS LS---L--D-PETAS
PKLM----------VS-----EDQKSVKRLLF----D--LD-V------------SPN--
SRRFDQDPCIL-----------AQER FE---AG RHY---WE-VE-V------GNRRAWIL
GVCLESLV-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KEKLQALSYP-R-----TC
---------------------------------LSPAEPLR---RVGILLDFEAGEISFR
NSTNGSL--IYVFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------METT--GL---PFP--------SLL------AL
VYLLQ-MV------------------------------------------TPSSEQ-FTV
--------S-GLA-RPVLASLGENVDLSCQLSPPQSAQHM-EVRWFRNRY-T---Q-PVH
LYENGKDMQGE----TISQYVERTVL-LTEAIGEGKV-ILRILNVSVDDDGQYHCL--FK
-D-G--DFYEEA-ITE------V--Q-VT-----ATSLEI-----------------QI-
------LMHPPNIK-GL-M---V--ECKSEGWYPQPQMEWRDSRG-EIILP-I-------
------S-------------------RN-HSRDRNKLFNVKMSLLLT-----G--SSQE-
NVTC-YLRNPV-TGQ-EERTS-------IVLS-DKLFP-------GKNIWILILFVMMAV
LLF-FIMVPSIEL-HFRQ-----------------------------------------N
CNLKDWKSPLIVGLGIVFPS---VGVIVGVVVSLHKK---------------ERVPVSDP
Q---FQLD--T--------------------LWL-EDMSV-ILCM-LLI-FITMLI-S--
F-----IYFRLRAAL--------------QSNHVHFP--------AN-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVEFPGYSLSGM---IASCFLIL
LTVKQQDDFRVLGPEGP-ILARVGEDALLTCRLLPKRSAAHMEVLWYRSEPRAAV-TAPQ
GGTDMVEVQVQECRGRLEMLED-SVTEGSVTLKIRSVQPSDSGQYWCRFQDRDYFGETSL
LLQVAGLGSAPHIHIT---------GN---QS---------------------------G
GVELLCTAEGWF----------PEPH---VR---WEDRWGERL-----------------
-LEVSEHHVLGED--------------------------------G------------LF
RVEDMLVVGNVSVV--------------------------------TETVSCFIHN----
PVLEDGKG------------------------------AVL--NLPEK-LQTEMAS-LQV
--------I-GPS-QPIPVRVGEDIQLTCYLSPKTNAQGM-EVRWVRSLW-Y---P-AVY
VHVNGDLMAGE----QMSEYRGRTSL-VSDAIQEGKL-TLQIHNARASDDGWYRCL--FE
-S---DGVYQEA-SME------L--K-VI-----AVGSTP-----------------LV-
------TVERRKAG-EK-Q---L--TCTSDGWFPQPHVQWKDTEG-RIVPSDP-------
--------------------------AV-LHQGQNGLFDVESHLLVT-----N--SSVM-
NVAC-SISNLP-LGE-EKTVA-------VSLS-ESKK-----------------------
------------------------------------------------------------
-----------------------------------------------------------N
F---------S---------------------WKMLPVLGL-LLVVT-------------
I-----GLIWMKS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------L-----RFGNGLTAGDT----W--QD-L------------PNN--
PERFNYNWCVL-----------GRQSFT---SGRHC---WA-VE-V------EVKNDWSL
GVCRENVR-R--K-GG--------------------------------------------
---------------ISESPADGFWAVQKL-----------YGDYRALTSP-R-----VY
---------------------------------LSLTTFPR---RVVVYLDYEAGDVSFY
NGTDGSH--IYTFPRAAF-S-GTLRPFFRLYYTD--------EFLTIC-PV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MV
---S---------------------------------SRLP---------TCL-----LT
LILLQLPK-------------------------------------------LDSAH-FDV
--------V-GPE-EPILAMVGEDVELPCHLSPNMSARNM-ELRWFRKKV-S---E-AVL
VHRDGQLQDKD----QVAEYRGRATL-VRDNLSQGRM-AVRIHGIKAKDAGEYRCF--FR
-E-KE--DFEEA-VVQ------L--Q-VA-----ALGSDP-----------------HV-
------HMAVQENG-EI-R---L--KCTSEGWYPEPHVQWRTAGG-QKFPS-M-------
------T-------------------ES-RTPDEEGLFTVAASVTIX-----X--XXXX-
XXXX-XXXXXX-XXX-XXXXX-------XXXX-XPL------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------S----WMV-VTIVV-VTV-----LGLLSIAS--
I-----FFTWRLYKERCRERK--------EKFSSK-------------------------
-------------------------------ENLLE-DL---KWK---KASLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-A------------LEK--
PERFDSWPCVL-----------GRETFT---SGKHY---WE-VE-V------GDRTDWAI
GVCKENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTSV-R-----TP
---------------------------------LPLPGPPR---RVGIFLDYESGDVSFY
NMTDGSL--IYSFPKTSF-S-GPLRPFFCLWTCG-------NRPLSIC-PVT-DGPDGVT
VLAD----T------------------------KD--------MSKEIPLS---PLGDDP
ATGDADT---PHSK---LIPTQPGQA--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------N-FTV
--------V-GPE-KSVLAYVGDEVEFPCHLSPYLDAEDM-EILWFRSQA-A---D-VVH
LYQGRRELYGQ----QMAQYQNRTEL-VKDDIADGSV-SLRLDRVTPEDEGTYGCC--FS
-S-G--DFSGEA-IWE------L--E-VA-----XXXXXX-----------------XX-
------XXXXXXXX-XX-X---X--XXXXXXXXXXXXXXXXXXXX-XXXXX-X-------
------X-------------------XX-XXXXXQGLFRLETSGCVE--------VTHN-
NVSC-SIQELV-LGQ-KKEFV-------VHIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LLRP--S----------------L----WKS-IFFGT-LVR-LLLLLA----LA--
L-----CFXXXXXXXXXKLKK--------QAEK-DKA-----------------------
------------------PNQAAL----DWRRAEGQ-----AEWR---AAQQHA----XX
XXXX--------------------------------------------------------
-------------------------------XX---------------------------
-----------XXXXX--------------------XXXXXXXXXXX---X--X------
----------------------X-XXXXXX-----X----X-X------------XXX--
XXXXXX----X-----------XXXXXX---XXXXX---XX-XX-X------XXXXXXXX
XXXXXXXXXX--X-XP--------------------------------------------
---------------SRMSPALGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALAVRVPPR---RVGVLLDCDAGTLSFF
NVSDGSH--IFTFTDKF--S-GALCAYFRPRAHDGS---EHPDPLTIC-PLP-VGGICVP
EEE-----EASDAYIQ----------------------------PY-EPD----------
------PALG-------RWR----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------LT-LVLYLP------FI-MLCL--EI
IY----SIISL--------------------------------------LYVFSGL-FHV
--------I-GPK-KPVIALVGGEALLPCHLSPSMDAQGM-KVMWHLNHL-S---E-VVH
YYGNFQDDLQQ----QSPEYQGRTEL-LKENITKGQV-ALRIHPIHVSDEGEYSCS--FA
-S-S--THSGEA-QLE------V--T-VT-----ASGIAP-----------------HI-
------HIEPSSTR-GI-K---L--TCKSTGWYPEPEVQWRDPKG-QPLTW-E-------
------T-------------------ET-MTKEENGLVLVESSITVD-----E--RSRE-
NPSC-FIKNPV-LNV-EKGAY-------MSIA-H--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
V---WRAI--KY---------------T----WFF-AL---------------SLIIP--
V-----LLIYYEDA--G-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------AAFF-----PA------P-GNPTIL--SE
NTVNLFPN---PST--------------------------------------QMSG-FSV
--------K-GPA-EPIMVLLGADATLPCQLSPEQSAAHM-HIWWYRTQL-S---P-AVF
VYQNGQEQGGE----QMLEYRGRTEL-VRNSINKGGV-ALLIQHVRASDHGQYRCH--FR
-D-G--QSSQEA-IVE------L--H-VI-----GLGSAP-----------------HV-
------HMMGPEDG-GI-R---V--LCSADGWFPKPRVQWSDVMG-VNLQS-L-------
------S-------------------EF-QTQDEDGLFRVEASLVVM-----D--RSLG-
NLTC-SIQNPL-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRM--D----------------P----WKA-ALAGT-VPI-----LMLLLAGI--
S-----YTGWRQHQAKEREVK--------KKKTESRE-RENLR-----------------
---------------------------------------AELDWK---KA----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LLYP-------------AHVT---I--N-QEI-H
QNNS----------DP-----ERK------ENFR--EETED-L------------SLSDK
--RGDCNRITL-----------NQEVFT---SGKHY---WE-VG-IEDTD------EWTL
GVYEKPAV-K--S-GL--------------------------------------------
---------------STNLQNKIFRVLE-K--K--------GCEYRALTCGLQDTSLKEH
---------------------------------LLLEKYPQ---KITIFLDYEDNDISFY
DMTQGTH--IFSFTQANF-S-GSLYPYFNLKS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAGFP
---N---------------------------------CGFP---------RCL-----LT
LILLQLPQ------------------------------------------LDS-VP-FDV
--------I-GPP-EPILAAVGEDAELPCRLSPNASAESL-EVRWFRRTV-S---P-AVL
VYRDGREQEAE----QMPEYRGRAAL-VQDGLAEGRV-ALRIRSVRVSDDGEYTCF--FR
-E-DG--SYQEA-LVR------L--Q-VA-----AMGSDP-----------------HI-
------TMQVQENG-EI-Q---L--ECTSVGWYPEPQVQWRNSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-CIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPK-L-T----------------P----WIA-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYKERSRE-K--------NEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------IY-----EDSKSVRLEDS----H--QK-L------------PEK--
PERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGHPR---QVGIFLDYESGDISFY
SMNDGSH--IYTFDNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PVA-DGPEGVT
VIAN----A------------------------PE--------LSKEIPLS---PMGEDS
ASGDADT---LHSK---LIPTQPSQG--TS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYRLSGA---VASFFFIL
LTMRPSDDFKVISPAHP-ILARVGEDALLTCQLLPKRTARHMEVRWYRSEPSTPV-FAQR
DGAELAEMQMEEYRGRVEWIED-NIAAGSVALKIYNIQPSDNGQYWCRYQEESYCGETSL
ELKVAXXXXXXXXXXX---------XX---XX---------------------------X
XXXXXXXXXXWY----------PEPQ---VY---WEDMEGEKL-----------------
-LTGSEHHIQDED--------------------------------G------------LF
YVEAILLVRDAS----------------------------------IETVSCFIHS----
VLLHEEKG------------------------------AVI--SIPEK-LQTELAS-LQL
--------I-GPS-LPILVEVGEDIQLTCYLTPKANAQSM-EVRWVRYHR-F---P-AVY
VYVDGDHVAGE----QMEEYRGRTAL-VSDAIVEGRL-TLQIHDARISDAGQYRCL--FE
-E---DGVYQEA-RLD------L--K-VA-----GLGSSP-----------------LI-
------TMEGLEDG-EI-Q---L--TCTSDGWFPQPHVQWRDMEG-QALPSFS-------
--------------------------GA-LTQGRHGLFHVETSLLVR-----N--LSTV-
NVTC-SISNPL-LGQ-EKRAT-------FSLS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAGFPGLF-----PA------G--VL-P-----
ALLLWVSM---WGS--------------------------------------PASG-FSV
--------M-GPA-QPIKVSLGADATLPCQLSSEQSAAHM-QIRWYRTQL-S---P-AVL
VYQDGQEQDGE----QMLEYRGRTEL-VEDSIGRGAV-ALLIQHVRASDDGQYWCH--FN
-D-G--HISREA-VVE------L--H-VI-----GLGSAP-----------------HV-
------RMMGPEDH-GI-Q---V--LCSSGGWFPKPRVQWSDTAG-EKLLS-L-------
------S-------------------EY-QTQDGDGLFHVEASLVVT-----D--SSLG-
NVTC-SIQNPV-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKI-ALAGT-LPV-----LVLLLIGI--
S-----YIGWKEHKAKNGEVE--------KRKKASHE-RDKVAREKEEA-HSLK------
------------RK-----LEEDLE-----QRKALY--NK--DWK---KALIYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFER-------------VLVI---E--N-HENVH
QNNS----------DF-----RK--------------E-PQ-A------------VLCKE
--QGGGNLLKL-----------DQKGFT---KGRHY---WE-VD-IEDTD------EWTL
GIYEEPTE-K--S-EL--------------------------------------------
---------------LSDLQKMKFNVLE-K--K--------GCEYRALICSRQGIFHKES
---------------------------------LPIEKCPL---KIVIFLDYEDSDISFY
NMTDETH--IFSFTHTNF-S-GSVYPYFKLKSME-F-------SPSA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------PTMV------RPL----------AFHLLHLPVC
LALVQ-------------------------------------------LLMPCSAE-FAV
--------I-GPP-EPILAMVGEVAELPCHLSPKMSAETM-ELMWLRSGL-R---Q-AVR
AYADGKEE--T----EIAEYRGRMSI-LRENIAEGKA-ALRIHKVRASDSGTYQCY--FQ
-D-A--DFVAKA-QVE------L--K-VA-----AQGSDL-----------------HI-
------EMKGYEDG-RI-R---V--ECTSAGWYPQPLVEWRGEGR-ESLPAM--------
--------------------------AAPGTADGEGLFAVTSSVILE-----G--GSGK-
GVSC-VVRNPL-LSQ-EKTAR-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DR
Q---FRR---H----------------P----WGL-LCSGG-CPV---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDDITAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNTKG-EDIPAV--------
--------------------------KAPVVADGVGLYAIAASVIMR-----G--SSGK-
GISC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WLA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMAYAATK-------------
----------------QEIS---------LRGI--------QKWK---MAL---------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------FKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--D-----------------------LVPD--------HSLETPVA------QGL
ANESGEPQAEATSP---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------VGLILVFTPA-------------------ICST--FL
CVILFPAL---GRD----------------------------------------DT-FMV
--------I-GPS-EPIVAMLGADAVLPCHVSPAMSVENM-ELRWFRSQF-S---E-AVY
VYQDGMEQVAE----QLVDFKGQAEL-VKDYITEGRV-GVRIYSFRASDNGMYKCF--FK
-K-D--SDFEEA-SLE------L--K-VI-----GLGSGP-----------------LI-
------LMVGPEGG-GI-R---V--ICTGKGWFPQPEVQWKDERG-EEIPS-I-------
------S-------------------ED-ETQDDDGLFQMEASLIVT-----D--STKG-
KVSC-SMKNPF-LGE-EQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKA-AFGVT-LPI-----LGTLLGAV--
L-----FLVWRERQEKKRAWQ--------A----EKE-KEKESKAKES--LK--------
---------------------------------------------------AE-------
------------------------------------------------------------
------------------------------------------------------------
-------------LDW-RK------ANLYAA-------------AVS---L--A-PDTAH
PNLI----------LS-----QSRRQVSCIENVP--Q-NCD-I------------PMYQG
QGSSETICSVL-----------GQEHFT---TGRHY---WE-VE-VNMGTEGRPGTRWAV
GVCSDTVK-R--Q-GW--------------------------------------------
---------------FIEKPEKNFWVVA-C--N--------EGKIEALTSKS------ES
---------------------------------LSLKQHPH---RIGVFLDWEAGDLSFY
NMIDGSH--IYSFTEITF-C-GNLCPYFSLQGPG-T-------SVTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGTI--GV---PLT--------AHC------VV
LFLLQ-MV------------------------------------------ALSTEQ-FTV
--------N-GLE-SPVLVPLGGNLELSCQLSPPQQAKHM-EIRWFKNRY-S---E-PVY
LYRNGKDLNEA----IVYKYVERTEL-LKDDIGKGKV-TLRIFKVTSVDSGSYHCF--FK
-D-D--KFYEEH-IIE------V--K-VT-----ATSSDI-----------------QI-
------LMHPPNST-GV-R---L--ECHSGGWFPQPHMEWRDSKG-EYIPA-T-------
------S-------------------KS-HSQDENEFFNMTMDLFIK-----S--NSYW-
SAAC-YIQNFV-THQ-EESIS-------FVLP-GTKVL-------LLKNI----------
------------------------------------------------------------
---------------QSIFQSSSVDLEKKDMLLKSIK---------------SRFQSSSV
D---PEKK--E-------------------------------------------------
------------------------------------------------------------
---------------------------------------------------R--------
--LLKIIQSRIESSSVD-----QETKALLL-------ESIQSSIENSTVDLETKVWLLES
IKSSIQNSSVDPETK---------------------------------------------
-------ELLLERIKS-----------------------SIENSTVD---L-------GT
KEWLLES---------------------IQSS----I--QS-------------------
-SSVDLGTKKM-------LLKIIQSSIQ---SFSVY----------------IGTKEWLL
ERVQSSIQSS-SV--DLGTKELLLEIIQSSIEGYSVELGIEELLSKIILSSIQSSRVDLG
IKELLVKICQSSIQSTSVILETKEWLVKIFQSNIQSSSMDLETKVWLVKFFQS-----SI
---------------------------------QSSSMDLG---TIKWLVKNVQSNIQSS
RVDLETKRMLLEIIQSSIQN-----SSVHRGTKKM--------LLKVIQSSI----QSFS
------VDLETKEWLLKI---------------IQ--------SSI------------QS
SS----VDIGTKSM---LLKK-------------IGLILRS-SIVNPG----TELLFQII
QSDLQSSSVNTETREMLFEITQPTVQSSSVNSVTEELLEENYQLLLQSSSVNLEAENILN
DTTQRILQLSSVNQGREKLLLDRIQQILQSSSVNPETKCWLLKRIQFILENPSVHQEKKD
LLLERIHLILQSSSVQKETKSLLLGSIQSILHSFSV---------------------QKE
TKYLLLEKIQLILQNSSVHQETKDLLLKIIQLILQYSSVHEATSKLLLERIQLILQSSSV
QKE---------------------TKDLLLNRIFSILQNSCVDQGVKYFLLNIIHPILQK
TSVHQETKSMLLDRIELILQSSSMQQETKNHLLDQIEQILQDTTVHQETKD---------
------------LLLNRIELILQNSSVQQETKELLMDKIDSILRYTWVHQETKDLLLNRI
ELILQSSSVQEETKNFLCNIIASILQSTSMHQEKKKLLLGRIELILQSSSVQQETKKLLL
KIVQSSSPSSSVRLESCNKRNPFWKKHALDLGISVFAIIVVTLIRHLNQREADQHFELDT
LWSKDTSVILCVLIMFNNRLKALIYFRLYGYSPPGKTYKYIVNYILRFSQPLFFIVYSAI
ILVMHLQIQNTDSLFSLYNSWMVEMIMVLGLLLAIFNVKNIATALLHLGRTTLRLFRIKD
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVLA
---N---------------------------------FYLP---------RYL-----LA
LILLQLPK------------------------------------------LDS-AH-FDV
--------I-GPP-EPILARVGEDAELPCHLSPNMSAAHM-ELRWFRNKV-S---Q-AVL
VHREGREQDAE----QIPQYRGRATL-VKGDITVGRV-AVRIHSVRASDDGEYRCF--FK
-D-DQ--SYEES-IVR------L--K-VA-----ALGSDP-----------------HI-
------HMEVQENG-EI-W---L--ECTSVGWYPEPQVQWRTPKG-EKFPP-T-------
------S-------------------ES-NNPDEEGLFTVAASMSIR-----G--ISLE-
NVSC-CIQNLL-LGQ-EKEVG-------ISIP-A-F------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L------------------T----WMV-AVAVI-ML-------GLL---T--
S-----IFIWRLYKERSRERK--------DEFSPK-------------------------
-------------------------------ERLLE-EP---EWK---TAKLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEN--
PERFDSWPCVL-----------GREAFT---SGKHY---WE-VE-V------GDRADWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPNNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LSLEGSPC---RVGIFLDYESGDISFY
NMTDGSH--IYTFPKISF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-GGPEGVT
VVAD----A------------------------QN--------LSKDIPLS---PIGEDP
ASGHTDT---LHSK---LIPTQPSQG--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SFL----------AFLLLIFRVC
LLLLQ-------------------------------------------LLMPHSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNNKG-ENIPTV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------R----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWQQQEEKKTQ---------FRKKKREQELREMAWSTMK-------------
----------------QEQS---------TRVKLLE-E---LRWR---SI---Q------
----------------------YASR----------------------------------
------------------------------------------------------------
------GERHS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCES FI---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LKLPKPPT---KVGVFLDYETGDISFY
NAVDGSH--IHTFLDVSF-S-EALYPVFRILTLEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGV---IASFFFIL
LTMKQSDDLRVIGPAHP-ILARVGEDVLLTCQLLPKRTAMHMEVRWYRSEPSTPV-FTHR
VGVEVTEMQMEEYKGRVELIED-GIAKGSVALKIYNIQPSDNGQYWCHFQDGDYCGETSL
LLKVAGLGSAPNIHME---------GS---VE---------------------------S
GVQLVYTTRGWF----------PEPQ---VY---WEDIQGEKL-----------------
-LAVSEHHIQDED--------------------------------G------------LF
YVETTLLVKNAY----------------------------------AESVSCFIYN----
PVLSEEKG------------------------------AII--SIPEK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCYLSPKANAQSM-EVRWVRSHR-Y---P-AVH
VYKDGDHVAGE----QMAEYRGRTVL-VSDTIDEGRL-TLQILSARPSDDGQHRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGRKDG-EM-Q---L--MCSSDGWFPQPHVQWRDMQG-RTIPSSS-------
--------------------------KA-LTQDSRGLFHVETLLWVT-----N--ISTV-
NVTC-SISIPF-LDE-EKRAT-------FNLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------WKTVLILGL-LLTVA-------------
V-----GLLRRRS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDFSRGS-----G--------LCRLISL----
LLFTQLPT---GGF---------------------------------------AQG-FTV
--------I-APP-DPIVAVLGGEVQLPCRVSPAMSAEDM-ELRWFRSKF-S---E-AVF
VYQDRLEQKEE----QMVPYAGRTSL-VRDLLNQGEA-AVRIQNVHVYDDGLYTCF--FK
-K-G--GFYEEA-SLE------L--K-VA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDVSG-EKFLA-F-------
------S-------------------EA-HTQDAEGLFSVEAALVVR-----D--SSVG-
NVTC-SILNPV-LGQ-EEAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFSVS-LTV-----LVILLLGA--
G-----CYTKKEHSTKVQEMQ--------AKETLCQT-REQDRQIKEEV-LKDT------
------------AK-LQ----EELE-----RRKSAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EEFQEW-------------PVN---L--D-PGSAH
SDLV----------IS-----HEKTSVTLKASPS--V-----------------------
--TSGDTCSVL-----------GFEGIT---TGHCY---WE-VE-IRDGD-ES---EWAL
GVCREGVN-R--K-GW--------------------------------------------
---------------YVESPDKGFWVVG-R--F--------ERGYFALTVPDT------P
---------------------------------LSLTQGPHPRLWGVGFLDHKEGDVSFY
NMTDGSH--IFSFPQASF-S-GTLFPYFMIRSGD-V-------SLTVC-SKV-GGSEGLP
VALS----N------------------------P----------SREESVSLPG-AGFSS
GSGADG-PPGAESP---LLPCNAEAV--SP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TAQ-FSV
--------I-GPA-EPVLALEGEDTEMHCHLNPKKSVEFM-EARWFRSQP-S---N-VVH
LYDSGAELFGE----QMEEYQGRTEL-VRDAMDYGSV-AVRLRNVRVSDEGNYLCS--FY
-D-G--NSDDEA-PLE------L--Q-VV-----ESGQDSVLV---------------V-
------SAQSGQDG-AG-LH--L--GFYLTPPSPHPNMAWPGKLL-PFVLP-HSAVCAPQ
TTRFSALHSTLLCTQEGRPGVSASAPGS-Q-HVVE-------------------------
-----------------QRH----R---NSVS-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPSG--L----------------S----LMV-ALGVT-LPV-----LGLLIAGG--
L-----YVFWNQHRDKGKETS--------SLWQ--GKAVDQMGK-GKTERLEPTNPR---
-AFFSHHSQPPQVQ-PQPQQS----------WEISF--E--KEWS---LFQL--------
------------------------HEA---------------------------------
------------------------------------------------------------
--------------------------------------------SVT---L--Y-PDTAH
PGLV----------LS-----EDRKRVTVGDK----R--QD-L------------PDN--
PERFSHNSCVL-----------GRERFT---SGRHC---WV-VE-V------GERRVWYL
GVCRENVR-R--K-AG--------------------------------------------
---------------ISVSPALGFWTLE-K--Y--------GDGYWAHTSP-R-----IP
---------------------------------LPLTTRSR---RVVVYLDCEAGAVSFY
SGTDGSH--IYTFSHAAF-S-GTLRPFFWLWSSDPA-------PLTIC-PVP-GWAGGDP
IP----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------V----------EGRRGKT-Y---------S-------------QL--LP
YLLPWFLT-------------------------------------------ITTGQ-FSV
--------V-GPH-RPILAKWGEDAELPCQLYPKTNAEHM-EIRWYRSND-S---R-LVH
LYPEGKDQESE----QMPEFQGRTTL-IRDAIAEGRV-ALRIHRVRVSDQGSYTCR--FQ
-S-S--I-IEEA-VLE------L--G-VI-----REGSVP-----------------VM-
------HVEGLGTE-GI-Q---V--VCRSEGWYPEPQIQWRDSTG-EILST-V-------
------S-------------------EPVMSQDVDGLYQVTVALPLR-----K--STNK-
TMSC-CIQNPL-LGA-KKESN-------IYIK-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------F
H---LPQNDSG----------------W----WGL-AVSGT-LNV-----ICLLII----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAAIP
---A---------------------------------PRLG---------VRL-----LA
LTLLQLPG-------------------------------------------LHFAP-FDV
--------I-GPP-EPILAMVGEAAELPCHLSSNESAAHM-ELRWFREQV-S---P-AVL
AHRDGRAQDAE----QMAAYRGRAEL-VQDDIAQGRV-ALRIRPVQASDDGEYRCF--FR
-Q-ND--RYGEA-SAR------L--K-VA-----ALGSNP-----------------HI-
------HMGVQESG-ET-R---L--ECSSVGWYPEPRVQWRTPRG-ETFXX-X-------
------X-------------------XX-XXXXXXXXXXXXXXXXXX-----X--XXXX-
XXXX-XXXXXX-XXX-XXXXX-------XXXX-XPF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WAV-ALAVI-LVV-----LGILIIGS--
V-----FFTWRLYRDQSGQRK--------AEFSST-------------------------
-------------------------------ENLLE-EL---KWK---KSTLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----EGSKAVWLEDS----R--QK-V------------PEK--
PERFDSWPCVL-----------GREAFS---SGRHY---WE-VE-V------GDRTDWAI
GVCREDVP-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGVFLDYESGDISFY
NMTDGSH--IYTFPDSSF-S-GPLRPFFCLWSCG-------KRPLTIC-PVT-DGLEGIT
VVAD----A------------------------KD--------PSREIPLS---PMGEDA
VPGDTET---LHSK---LIPTQPSPG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENHRKPS-----LLF---HVP-CLF-------
-VLTQLLS---WVT---------------------------------------TQE-FRV
--------F-GPS-DPIVAAPGGEAILPCSVFPAMNVENMEELRWFRSRF-S---E-AVL
FYRDQEEQKEG----QMPGYSQRTLL-VKDQFHQGTA-AVRILNVQASDSGIYICH--FQ
-Q-G--VFYDEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------HIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWKDSRG-ENLTAFS-------
------S-------------------ET-HTKDAEGLFSTETLLVVR-----D--SSVR-
NVTC-SIFNPI-LGQ-EKATA-------MFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFLVT-LTM-----MGLLVLGT--
S-----YLLRREHSARLKVQQ--------ETVNFQRE-KDESLKTRDDA-L---------
------------RT--AGALMVERD-----RRKAAY--R--AAWK---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFEAW-------------TFT---L--D-PASAH
PILA----------IS-----PDRLSVSRKDSTL--C-----------------------
---LDDLFCVL-----------GIRGIS---SGRHY---WE-VK-LRNGD-SS---KWTL
GVCREGVD-R--K-GC--------------------------------------------
---------------FSECPHKGFWTVG-R--S--------SSGYLAYIDTGT-----AL
---------------------------------LSLRQAPQ---SVGVFVDYTEGDISFY
NMSDMSP--MFSFHEASF-S-GTLFPYFRLKSGN-V-------SMIIQ-SMA-CASEGRE
GEDR----RRGRKRSRKG---RKGKRTKRGKKLVL--------LPLEESLSPAG-EGLVP
GSCVVDSFPEEVSP---FLQHARNSL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------L--P-PA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDLSG-EKFLA-F-------
------S-------------------EA-HTQDAEGLFSVEAALVVR-----D--SSVG-
NVTC-SILNPV-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFSVS-LTV-----LVILLLGA--
G-----CYTKREHSMKMQEMG--------EKETLCQT-SEQDRQTKEEV-LKDA------
------------AW-RK----AQ-----------LY--A--GHGQ---GSGIQN------
------------------------------------------------------------
------------------------------------------------------------
--------------YW-RK------EEFQEW-------------PVT---L--D-PGSAH
SDLV----------VS-----HEKTSVTLKAS-C--V-----------------------
--NTADTCSVL-----------GFEGIT---SGRCY---WE-VE-IRDGD-QS---EWAL
GVCGEGVN-R--K-GL--------------------------------------------
---------------YIESPHKGFWTVG-R--F--------ERGYCACTVPQT------L
---------------------------------LSLMQAPHPRLRVGVFLDHQEGDISFY
NMTDGSH--IFSFPQASF-S-GTLFPYFMIRYGD-V-------SMTIC-SK---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
---S----S--------------DSGIMGAK---G---VLV--------THC------VI
LYLLQ-MV------------------------------------------ALSSEE-FTV
--------A-GLT-GPVLAPLGGNLELSCQLSPPQNAQHM-EIRWFRNLY-T---Q-PVH
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLKIFNVSASDDGPYHCI--FK
-D-G--QFYEEH-IIE------V--K-VT-----VTSSDI-----------------QI-
------LMHPPNTK-GV-M---L--ECHSGGWFPLPHMEWRDSKG-EVIPA-T-------
------S-------------------KS-HSQDINKLFNVKMVLFIE-----A--YYHR-
NVTC-CFRNLL-THQ-EESIS-------IVLS-DELFS-------WRRVWITILSLIACV
LIA-FLLTSCVQQ-YPIFGR----------------------------------------
-------CPWKKSAMLFMIS---MFAIGGVNLILYQR---------------QRVPVSDP
H---FELD--T--------------------LWV-EDISV-VLCV-LIV-FIIKLI-S--
F-----IYFRLK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVCSPDF----------------SLLRDL--FL
ILLFQMSM---KGS----------------------------------------DS-FLV
--------I-GPS-EPIVAMLGADTVLPCRVHPAMNVENM-EIRWFRNQF-S---E-AVF
VYQNGMEQVGE----QLVDFKGRAEL-VKDYITEGRV-AVRIHSLRVSDNGMYKCF--FK
-K-G--TDFEEA-ILE------L--K-VI-----GLGSGP-----------------RV-
------FLVGPEDG-GI-R---L--KCTGKGWFPQPEVQWEDVKG-EKIPS-V-------
------S-------------------ED-ETQDDDGLFQIEASLIVR-----D--SSKT-
QVSC-FMKNPF-FGQ-EQVET-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRP--S----------------P----WKA-AFAVT-LVI-----LGISAGAI--
V-----YLAWKERQGKKKLSK--------V----KEE-KEKESKSKES--LE--------
---------------------RELA-----RRKEL---YQ-QDWR---KAELY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------EQFKAA-------------AFT---L--D-PKTAH
PNLV----------LS-----ENKQHVSLKNNVS--Q-NGD-A------------STHEE
QRDSEGIFSVL-----------GEKSFTQRDTNRQY---WE-VE-VKTRTEAGSATRCVL
GICSETAK-R--E-GW--------------------------------------------
---------------FVETPDKNFWVLV-H--E--------EGKVIFPNSQE------NS
---------------------------------PSLRQQPH---RIGVFLDWKAGNLSFY
NMADGSH--IYSFTGITF-C-GTLFPYFSLRGTG-A-------SLTIC-STS-DHPENCP
DSSL----KTSLTHLS--------------------------------------------
-SC-DTSVPQEANS---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLWLSV-------------------------------------------HV-SG-R--
--------A-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-AVH
VFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPI-----LVLLIMGC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------P
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEEST
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MMK--FS---CFS--------GFC------VY
FLFLQ--V------------------------------------------MVSSEK-LRV
--------T-TPT-RHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGL-S---Q-PVY
LYRGGHKMTEE----AAPEYANRTEF-VKEAIGEGKV-SLRIYNINISDDGSYQCS--FN
-G-S--GFIDVA-IMN------L--N-VT-----AVGLET-----------------EI-
------HVQAPDAD-GI-M---V--ECNSGGWFPRPQMEWRDSKG-ATFPH-S-------
------L-------------------KS-YSQDEARFFHMKMTL-LT-----N--MSQG-
SIIC-CIFNPV-TGE-EKQTS-------IILA-NELFN-------QEHIWMKSLVSI-AW
I-ILIVYILFIICSSCRTGCAS-----------------------------------GRL
SKCFRVVTSWPVQVLH--FI---FCTGILFGIYLPHR---------------HRVLLSDP
Q---EQPR--K--------------------SWE-KEK----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GL---CFY--------GHC------IV
MFLLQ-MI------------------------------------------TASSEP-FIV
--------N-GLE-GPVLASLGGNLELSCQLSPPQQAQHM-EIRWFRNLY-T---E-PVH
LYRDGKDMFGE----IISKYVERTEL-LKDVIEDGKV-TLRIFNVTVDDDGSYHCV--FK
-D-G--DFYEEH-ITQ------V--K-VT-----AINLQV-----------------QI-
------HVHPPNTK-GV-I---V--ECHSGGWFPRPLMEWRDRNG-EVIPA-A-------
------S-------------------KS-HSQGRDKLFNMKISLLVR-----D--SFFK-
QVIC-CFQNPL-TGQ-EARTS-------VILS-DAFFS-------WNSIWKMILGITVSM
MVL-SIFVSSFLL-RNEPKVCR--------------------------------------
---CLWDASRMIGILIMTSS---AVTVVSLMVYLQMK---------------QRVPVSDV
H---FELD--T--------------------LWV-EDISV-ILCS-LMV-PATMLI-S--
Y-----TYFRLKDWC--------------QHNHSQKD--------FTS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FTV
--------L-GPA-DPILAMVGENTKLQCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGRRERTEE----QMEEYRGRTTF-VSKDISKGSV-VLIIHNVTANENGIYRCY--FQ
-E-G--RSYDEA-IIH------L--M-VA-----GLGSKP-----------------LI-
------EMKGHEDG-GI-R---L--ECTSVGWYPEPRAVWREPSG-EIMPSLE-------
--------------------------EA-YTVNADGLFRVTMAVIIR-----D--HSVR-
NVYC-GGGNTL-LNQ-EKETV-------IFIP-ESFIP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----------------------L---ITG--S
I-----CLIRKLKREKKF-LSV--------QKRVQNEEKEAARKELG-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KEKER--Q-----------------------------------------
----IKE-QLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSR----QS-I------------PDN--
PERFDCQPCVL-----------GLESFS---SGRHY---WE-VE-V------ENVMVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPLKERLH---RVGIFLDYESGDVSFY
NMRDRSH--IYTCPRSPF-S-R-------LGPSQGR-------D--------------PP
QPP--------GPV------PWSQSQVEKP--KPPLLPQHS-TFPPEVPTSS--------
-----------PSP---L--------------SLIRLCF---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA--FS---SLS--------GYF------VA
ILLLQ-IT------------------------------------------VLTSAQ-FTV
--------S-SSR-SHHVVMVGSQAELSCRLSPPQNAQLM-QVGWFRDRH-S---Q-MIY
LYEDGEEHSGE----GIQNYMNRTVF-LKDALEEGKI-TLQIYNVTVFDGGQYHCF--FK
-D-G--HTYEEG-IVD------L--R-VA-----AVGLGV-----------------QI-
------NVQVLNTE-GF-V---V--ECTSEGWFPQAQMAWRDSSG-NVIPH-S-------
------S-------------------KS-YSQDGAGLLHLQMTILLK-----N--STHG-
PVTC-CFYNPV-TGQ-EKRAG-------IVIS-DILFK---------SEYMSLMSHK---
-------ISY-PWIYLSIVVALLF---------------------------------LRI
-KVAQNIRCVHLVFQCLPFL---MY-IGILPIYLQF---------------RKRVSVSDD
L---FLLY--S--------------------IWT-EDLCI-ILGI-LML-FFTLLIFV--
L-----LYTLKGK-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MMDFS
---VSLDSTALG----------FFLDSLYQV-------PLSSS------LFFLTHFLL--
--LFPLVQ------------------------------------------L-SSEK-VKV
--------V-GPG-QSILALIGEEIEFPCYLWPYLDAEHM-EIRWFRSRP-S---D-IVL
LYGEQQELSRG----QMAEFQNRTKL-LKDEIRDGHV-ILKLHSVVPSDEGRYGCS--FL
-S-S--NFTGEA-IWE------L--E-VA-----GMGSDP-----------------HI-
------SLEGFKEG-GI-H---L--RCSSSGWYPKPKAQWRDHQG-QWLPL-E-------
------S-------------------EA-VIQDVQGLFSLEISVVLR-----E--GAHS-
NVSC-SIQNTL-LVQ-SKEFV-------VEIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---FPTT--S----------------S----WKG-AFLRT-LAG-LPLLMVLLMVLV--
L-----YFFQQQQRTQEKLKK--------LAEK-EKG---KLQ-----------------
------------------TELADA----DWRRAEGQ-----AEWR---AAQRYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLV----------VS-----EDGRSVSSR---EAVL--AL-A------------VGA--
SQWFVEQTCVL-----------GRERFS---AGCHY---WE-VH-V------GHRSRWFL
GVCLATVP-R--V-EP--------------------------------------------
---------------ARLTPASGYWVMGLW--N--------SCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---CVGVFLDFEAGRLSFF
NVSDGSH--IFTFTDTF--S-GPLCAYFRPRAHDGS---EHPEPLTIC-PLP-IRGTRIL
EED------DSDTWIQ----------------------------PY-E------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------R--GA---I-----------VI------LV
VVLFL-YF------------------------------------------NRNEHT-ATM
--------E-TIF-RPILAPLGGKVELSCQLSPPQSAEHM-EIRWFWSHY-T---R-PVY
LYKDGKDLYGE----TISKYVERTEL-LKEAIGEGKV-TLRILNVSADDDGQCHCF--FK
-D-G--DVYEEA-ITE------A--K-VT-----ATSLEI-----------------QI-
------LIHPPNSK-GL-L---V--EYNSEGWFPQPQMEWRDSRG-EIIPP-A-------
------S-------------------KS-HSQHRNKLFNMKMSLLLR-----D--SSHG-
NITC-YLQNPV-TGQ-EERTS-------IVLS-GAI------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARA-HPGD-VILPSI----LVS---FIL--LQ
LLTSG----------------------------------------------NGKSD-FLV
--------L-GPP-HPLLAIVGQDKELPCKLSLNISAEGM-ELRWYRDKP-S---S-VVH
VYKNGEDVYDE----QMTEYKGRTSF-NGSHVARGEA-AVKIHNITVFDNGTYHCV--FK
-E-Y--TSHSQA-TLW------L--K-VA-----GRGSSP-----------------RI-
------RVTDTQDK-GI-R---A--ECTSAGWYPEPKVEWLDLKG-QPVSA-E-------
------S-------------------HF-SVSASTGLVALLSIVTPQ-----D--TAVG-
GLTC-SISNPL-LPE-KVTE----T---YLL--A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---SRRP--L----------------S--TESGP-ALPLI-LTA-----LGLVSAAI--
A-----CAFGKCHKEEHKTNQ--------EEEDPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AR-D-------------------EAGLFHVS LS---L--D-PETAS
PKLM----------VS-----EDQKSVKRLLF----D--QD-V------------YPS--
SRRFNQDPCIL-----------AQER FE---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLV-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TC
---------------------------------LSPPEPLR---RVGILLDFEAGHISFY
NSTNGSL--IYVFSGFSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-TETKEDT
ESSG----D------------------------PG--------LPGDS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MALFKPADVI---L--D-PDTAN
PILL----------VS-----EDQRSLQRAEE----R--QD-L------------PDN--
PERFDWHFCVL-----------GCES FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LTLPEHPT---KVGVFLDYETGDVSFY
NAVDGSH--IHTFPDISF-S-EPLYPVFRILTLEPT-------ALTIC-PAQ-KGVESC-
PD--P--D-----------------------LVPD--------HSLETPVA------PGL
ANESGEPQAEVTSL---LLPAHPGA-DGLPLH--------S-NQAEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLPGV---AASFLFVL
LTMKHPEDFRVIGPAPR-ILARVGEDALLTCQLFPERSAEHMEVSWYRSEPSTHVLFAHR
DGAEVSEMQAEEYRGRVEWVEH-DLAKGSVALKMHNIQPSDDGQYWCRFQDGDYHGETSL
LLQVAGLGSAPHIHME---------GS---MA---------------------------G
EIQLVCTADGWF----------PEPQ---VH---WEDSRGEKL-----------------
-LTLSEHHIPHED--------------------------------G------------LF
HVEATLVVRNAS----------------------------------TETVSCSIHN----
PVLTEEKG------------------------------TVF--SIPEK-LQTELAS-LKV
--------I-GPS-QPLLVRVGEDIQLTCCLSPEANAQSM-EVRWVRAHR-Y---P-AVY
VYMDGDHVSAE----QMAEYRGRTVL-VTDAISEGRL-TLQIHDARTSDDGQYRCL--FE
-K---DGVYQEN-TLD------V--K-IV-----GLGSSP-----------------RI-
------TMEGLADG-EM-R---L--MCSSEGWFPQPRVQWRDLEG-RTVPSFS-------
--------------------------EV-LAQGSDGLFRVEAFLQVT-----N--SSAG-
NVTC-SIGNPL-FGE-EQMTT-------FFLS-GG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MS----------S----INNLKMP-------------FLQFLVSLL----
FWGSEHLC---SMS---------------------------------------TDE-FQV
--------I-GPS-KPIVAMLGGDATLPCSLFPPMNAEDM-ELRWFRTKF-S---E-VVF
VYRNRREQHKE----QMPQYAGRVLL-VKELLTQGQA-AVHIKKVWASDNGTYTCF--FQ
-K-G--GHYAEA-ILE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGPEQD-GV-R---V--VCKASSWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEVALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKVMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFSVS-LTV-----LGLLLLGA--
G-----CFTRRERSAKLQERQ--------KWEKLCRA-KEEDQRAKEEA-LKAR------
------------DE-LQ----EELD-----RRKTAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ERFQAW-------------PVT---L--D-PVSAH
SGLA----------LS-----PDKMSVTWKY-TT--G-----------------------
---KDILCPVW-----------GLEGIT---SGRCY---WE-VE-IRSGV-YN---WWSL
GVCRENVT-R--T-GR--------------------------------------------
---------------YLESPDMGFWVVK-R--I--------INNYYARTKS-R-----QA
---------------------------------LSLRQEPR---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFSPTSF-S-GTLFPYFSLR-GD-V-------TLSIC-PTE-GRSEGLP
VPLS----K------------------------SP---------SLEEAVRPPG-EGLSS
GSG---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MT
VLTLLSL-------------------------------------------RLGSGQ-WQV
--------I-GPD-KPVQVVVGDDAVFSCFLSPKTSAEAM-EVRFFRDQF-Y---A-VMH
LYREGKDQHDV----QMPAYRGRTEL-VTDFIAEGHV-SLRLEKVTLSDTGLYGCW--FS
SQ----TNDQEA-IWE------L--Q-VS-----GLGSGP-----------------LV-
------SIVGYVGK-GI-Q---L--LCKSSGWFPQPIVKWKDPQG-HDLPSDS-------
---------------------------K-VNADRHGLFDVETSLIVQ-----E--N-AG-
SISC-SIQYPD-QSQ-EVESR-------VWIR-ETFFQF---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------S----YRL-ASILLGILS---CVLCVGITGE--
-----VIFYSKSKSE-----K--------HQL----------------------------
------------------------------------------DWR---KKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------VSELRDARKHAVEVT---L--D-SDMVH
LQVY----------IS-----D-LKAVSYSNV----T--QM-A------------TFL--
EKRFL-KKCVV-----------ASQGFQ---EGKHY---WE-VN-V------GCNKMWSL
GVCRDDVN-M--E-MTD-------------------------------------------
---------------VTLSPNNGYWVLGLE--R--------ENQYFTFNPH-R-----II
---------------------------------LSPRTPPT---RVGVFLDYEVGAISFF
NVNDQSF--IY-TLTHHFEG-L-LRPYIQHYVND-E---ENMTSIVIC-PVS-QES----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--VL
TLVLSLL-------------------------------------------RLGSGQ-WQV
--------I-GPD-KPVQVVVGDDAVFSCFLSPKTSAEAM-EVRFFRDQF-Y---A-VMH
LYREGKDQHDV----QMPAYRGRTEL-VTDFIAEGHV-SLRLEKVTLSDTGLYGCW--FS
SQ----TNDQEA-IWE------L--Q-VS-----VLGSAP-----------------LV-
------SMTRRIDG-GI-E---L--LCESSGWFPQPTVKWKDPQG-HDLPSDS-------
---------------------------K-VNADRHGLFDVETSLIVQ-----E--N-AG-
SISC-SIQYPD-QSQ-EVESR-------VWIR-EVFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------L----------------P----WRL-SCIFLGVFA---SVLCVGVIGL--
-----TIFYRKWERR----IW--------AET----------------------------
------------------------------------------YWR---KKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------VSELRDARKHAEEVT---L--D-PNTAH
LQLC----------MF-----D-LKTVTSRNT----H--QE-V------------TFS--
MKRFL-KKCVM-----------ASQGFQ---EGKHY---WE-VD-V------GYNKMWSL
GVCRDDVD-R--E-MTD-------------------------------------------
---------------VTLSPDNGYWVLGME--R--------ENQYFTFNPH-R-----II
---------------------------------LSPRTPPT---RVGVFLNYEGGAISFF
NVNDQSF--IY-TLTHQFEG-L-LRPYIQHYVND-K---ENVTSIVTC-SVS-QESEKEV
LSD---------------------------------------------------------
-TDNLEPLPQVTTP---FLSGDAL------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------M-ASCS-----S-----FLLYSYLI-----I
FLSLQLPT-------------------------------------------EGS------
----------GKIGKRNLVLLGTKAELRCPLSLWMVPESI-EVKWLRTQKSS-SAQ-TVH
VYRNGQDFYGE----QMPQYKGRTAL-VRDN-QEDNF-ILEIYNVQLEDQGQYYCQ--IQ
-A-G--ILSKNA-TVK------L--E-VA-----ALGLDP-----------------YI-
------HMKSYEDG-QI-Q---L--VCRSLGWFPKPQIQWRDTHG-EILPS---------
--------------------------ET-QYLEKEGLFQMETSISLR-----N--VSPG-
NMTC-SIWNAA-LDQ-EKKTT--------------------------------LFI----
------------------------------------------------------------
-----------------------------------------------------AAFSHLH
V---A-----P---------------------ST-VGLVVI-LPI-----LGLLIALG--
I-----YIIWKQRRAREKLLYQ--QVVEIE-NLLSDHGKEK-GR----------------
---------------------------------LH-------------KGL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKHRAELKL-----------KRSAANAGWRRAKLHPVDVT---L--D-PDTAH
PKLL----------LS-----EDLRSVRLGDK----R--QD-V------------PDS--
PKRFDFVVSVL-----------GSPSFT---SGCHY---WE-VC-V------ADKTKWIL
GVCSEAVT-R--K-GK--------------------------------------------
---------------ITASPSNGHWLLRQS----------RMNEYEALTSPQT------C
---------------------------------FHLKESPR---RVGIFLDYEAGLVSFY
NATNKSH--IYTFTHAF--S-GPLRPFFEPCLHDEG---KNVAPLIIC-SAS-QSSEEFL
DSNL---------------------------------------------------SPET-
-PQNEKQISGIGNGSIPLK----SNL--YPLQ---DIISSWPSDVPPALQGLRAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLHSC-----LLASLVF-----
FLVLSLYV-------------------------------------------MVSAQ-FTV
--------L-GPA-EPILAMVGENTTLYCHLSPERNAEDM-EVRWFRWRL-S---P-AVL
VYKDHQEREEE----QMAAYQGRTTF-VSTDISKGRV-ALIIHNVTAYDNGIYYCY--FQ
-E-G--RSYDQA-IMR------L--M-VA-----SLGSKP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYY-EIVPALE-------
--------------------------EE-CTADRGGLFTVTMTVIIR-----D---SVR-
NMTC-SVNNTL-LNQ-EMESV-------IFIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AMAVT-LPVLMLILL---TSG--S
I-----CLVKKHHRKKSI-LS---------------PEKEVEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ENARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVRR--GASR----QS-V------------PDN--
PERFDCQPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPET------I
---------------------------------IPLKERLH---RVAIFLDWEAGDVSFY
NTRDRSH--IYTCPPVAF-A-GPLRPFFRLGSDDSP-------L-FVC-PAF-TGAQGVI
IPE--------GGLILYRTRPVCQSHVKEP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MKVLSFC
---SS---------------------------SAVS-SCLP-G-----------LI--IF
FITYHIQK-------------------------------------------LESAE-FTV
--------L-GPA-HPVTATVGQAIQLPCHLSPRMSAENM-EVRWFRSEF-F---S-FVH
LYQDGKDEYEQ----QMPDYQGRTEF-LKAGLAEGNV-SLRILNIRPMDRGQYHCF--VR
-D-G--TLYEEA-LLE------L--K-VA-----VLGSSP-----------------LI-
------SVQGHQDG-GI-R---V--VCQSAGWYPEPEVLWRDHIG-HLLTS-L-------
------S-------------------EA-KSQVDNDLFRTESSIIMR-----E--QANQ-
SLSC-CIRNTF-LNQ-EKES----T---IYIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRA--S----------------P----WMV-ALIVI-LLV-----LFGFMGLI--
A-----YLFKLK----GKYHR--------G-E----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASMIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----IPS-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNQRSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DRPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SL-----TGHAKGLL--TS
LVTLLLLQ-------------------------------------------LGSAQ-LRV
--------V-GPD-YPLTATVGQDVVLRCYLSPQRDARSL-EVRWIRDHI-S---E-TVH
HYRNGEDLYGE----QMGAYAGRTEL-SRDGLSAGSL-DLRITGLRPSDDGRYICI--VK
-D-A--DVYDKA-TVD------L--E-MS-----ATGTDP-----------------HL-
------SLRGYEAG-GV-R---V--LCRSAGWYPLPQLLWRDARG-QHLPS-V-------
------S-------------------QK-HSKDQEGLFEIEGAIIVT-----G--SMEG-
PLSC-VVRNSR-LQQ-AAQS----R---E-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------LGE--------SLQSLPP-----------AP-----------
--------------G-EVVSVREG---LGWVGSGGL--C--AAWA---RDTAGM----DE
RN----------------------------------------------------------
--------------GDQVSFSE--------------------------------------
--------KKAA--EL-XX-----------------XXPSVPAVKVT---L--D-PHTAH
PELI----------VS-----EDHRSVRRESK----S--QQ-V------------HNS--
QDRFKYRCCVL-----------GHEEFR---EGRHC---WE-VE-VEVEGELENESCWAV
GVTRASVN-K--K-EK--------------------------------------------
-----------------IFPQHGIWALM-Y--Q--------QGQLMPLTSP-Q-----IQ
---------------------------------LPLSPVPT---RIWVCLDCTQQQVSFI
NADNGVE--IYTFTAASLNG-ESFRPWFLLETLG--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFQVC
LLLVY-------------------------------------------LLLVTTAQ-FAV
--------L-GPL-GPILAMVGEDSDLPCHLFLTVSAETM-ELRWISSSL-R---R-VVN
VYADCKKMEDS----QSA----ETSI-LQDGITAGNT-ALPIYNVTASDNGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVKGCEDG-GI-H---L--ECRSTGWYPQPQIQWSNIKE-ENIPAV--------
--------------------------EAPVVADGV-----AASVILR-----G--SSGE-
GVSC-IVRNFL-LGL-EKTAS-------ISIE----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRST--Q----------------S----WIA-ALEGT-LPI-----SLLLLAGA--
S-----YFLRQQQKEKIAL---------SRETERERKMREMGLCLKG-------------
----------------EWSV---------EKNKNT--------------DLFLI------
----------------------C-------------------------------------
------------------------------------------------------------
---------VS--------------------FLSEWKMALFKPAYVI---L--D-PDMAN
AILL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PERFEWRYCVL---------------------GRHY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYQ--------------
--------------------------------------------KVGIFLDYETGEISFY
NATDGSH--IYTFLHASF-S-EPLYPVFRILILEPT-------ALTIC-PTP-KEVESSP
D---P--DL----------------------M-PD--------HSLETPVT------PGL
ANESGEHQAEVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FLGFLKQW---------WSS------IFF-THFLL--
--FLQLGE------------------------------------------VD-SDE-FKV
--------L-GPG-ESLMALVGETVEFPCHLSPYQDAEHM-EIRWFQTQV-S---N-VVY
LYQEQQGLSSP----QMMQFRNRTIF-EANDIADGSV-ILHILSVVPSDEGQYGCR--FL
-S-H--NFSGVA-TWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCS-------PKAQWRDHQG-QCLPP-E-------
------S-------------------EA-IVQNAQGLFSLDTSVIVR-----G--GAHS-
KVSC-SIQNPL-LAQ-KKEFV-------LQVA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRT--S----------------P----WKK-AFLGT-LVA-LPLSLAVLTILA--
L-----QYFYKQRCSQEKLKK--------QGEK-DRE-----------------------
------------------RLQTEL----DWRRSEGQ-----AEWR---AAQRYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTTAH
PSLE----------VS-----WASDEALW-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------NMASPLHI----------------SMPTEL--LS
ILLLQAAI---WGS----------------------------------------DS-FIV
--------S-GPS-EPIVAKLGSETVLPCQVDPPMNVETM-ELRWFRSQY-S---E-VVY
AYRDGMAQVEE----QLVDFKGRAEL-VKDYISEGKV-AVRIHSLRVSDNGMYKCF--FK
-R-D--NDFEEA-TLE------L--K-II-----SLGSGP-----------------HI-
------LMVGPEDE-GI-R---L--TCTGKGWFPQPEIQWKGEGG-EKLPS-L-------
------S-------------------ED-ETQDDDGLFQTEASIIIR-----D--RSKR-
EVSC-SMKNPF-FGQ-EQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WRA-AFAVT-FFM-----LLICLGAV--
V-----LLAWKKKQAKKRVQN--------A----KDE-KEKERQAKE-------------
------------------NLEKELA-----TRKEL---YQ-HDWK---KANLY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------KNFEAV-------------DVS---L--D-KNTAH
RSLT----------IS-----GDGKRVSLEKNVV--Q-NSD-A------------SKTQG
TGGSGTIFSAV-----------GQNCFA---TGRYY---WE-VK-VLGEKEMGHGARWAL
GICPETVN-R--T-GW--------------------------------------------
---------------FVENTEKNFWLVA-Y--K--------EGKVTTLTSKP------ES
---------------------------------LSLRSYPE---RIGVFLDWEAGDLSFY
NMVDGSH--IYSYTGINF-C-GKFQPYFSLQGAG-T-------SMTVC-SAS-GQTENVP
SSSA----ETSVTHLR--------------------------------------------
-NS-DTDVPQETNT---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------VSE-FSV
--------K-GPD-EPINVLLGADATLPCQLSPEQSAAHM-HIRWYRDQL-S---P-AVL
VYQNGQERGGQ----QMLEYRGRTEL-VGDSIHKGSV-ALLIQHVRASDNGQYQCR--FE
-D-G--HISQEA-IVE------L--H-AI-----GLGSAP-----------------HV-
------HMMGPEDG-GI-R---V--LCSSGGWFPKPRVQWSNMAG-VKLPT-L-------
------S-------------------ES-QTQDGDGLFYVEASLVVT-----D--SSLG-
NVTC-SIQNPF-SGQ-EKVSA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKA-ALAGT-LPV-----LGLLLIGI--
S-----YTGWREHQAKEREVK--------KTKKESHE-RDQMRNEKEMA-LTAK------
------------AN-----LEAELE-----GRKALY--NE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFQL-------------APVT---L--S-HEIFH
QNNS----------DP-----ERK------ENFR--EGTQD-L------------SLK--
----DCNLITL-----------TQEGFS---FWRHF---WE-VD-IEDID------EWTL
GIYEEPIE-N--N-KY--------------------------------------------
------------------LQKKKYRVLE-K--K--------GCEYRALTYCLQDISLEKS
---------------------------------LPIEKCPR---KIVIFLDYEDGDISFY
NMTDGTH--IFSFTQASF-S-GSVHPYFKLKSME-M-------SSSAQ-C----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLGLPA-------------------------------------------HV-SG-L--
--------A-GDASKFHVAPLGGTAELLCPLSLWPGTVPK-EVRWLRSPYPQ-RSQ-AVH
VFRDGKDRDED----LMPEYMGRTAL-VRDP-QEGSV-TLQILDVRLEDGGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
V---S-----P---------------------SA-MALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRRELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDS----R--QS-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---SGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYDAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEERI
VPKP---------------------------------------------------EGKG-
-YANGDMSLKVNSS---LLPRKAPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MK----------II-VSLFFCFLA-------------LLAFCFLAL----
LVLFLTPM---SVS---------------------------------------TEE-FMV
--------I-GPS-EPIVAVLGGDIMLPCRVSPAMDVQNM-ELRWFRSKF-S---E-AVL
IYQNQREQREE----QLAQYRGRTSL-VKDFLTQGEA-AVRIHNVQAFDNGLYTCF--FR
-M-G--IFYEEA-GLE------L--K-VA-----GVGSAP-----------------QV-
------HITGPEED-GV-R---V--VCMALGWFPKPQVQWRALSG-EKFLT-F-------
------S-------------------ET-QAQDAEGLFTINATLVVR-----D--PSSG-
NVTC-SVLNPI-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRS--S----------------P----WKL-AFMVI-LTV-----LMLLLLGA--
V-----FYIMREHTAKLQEMQ--------EWEKLHRD-KKEDQQIKEEA-LKAR------
------------DE-LQ----ADLD-----WRKSVY--L--ASLK---KAKLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQT-------------LTVS---L--D-PESAH
SILA----------LS-----DDKTSVTFKDSCK--G-----------------------
--SEDGVYSVL-----------GHEGIT---SGCCY---WE-VE-IKNAE-RS---EWAL
GVCRRDVE-R--K-GW--------------------------------------------
---------------YQESPEKGFWVVA-M--Y--------DNIFGS--LPAN------G
---------------------------------EHIVPIPQ---RVGVFLDLKEGDVSFY
NMTDGSH--LFSFPLASA-S-GTLLPYFRLRSGN-V-------SLTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FKV
--------M-GPD-RPVTAVVGEEIVLPCHLAPRMSTENM-EVTWFRSQL-F---Q-FVH
RYSDGKDQYEQ----QMPEYQQRTEL-LKD--EQGNV-TLKILHVRLSDEGQYRCF--VQ
-D-G--AFYEEA-VLE------L--K-VA-----ASGSAP-----------------HV-
------SIEDYQDG-GI-R---V--ACRSAGWYPEPEVMWRDLNG-QAFPS-A-------
------S-------------------QT-NSREANGLYRTETSAIIM-----E--NSNR-
NLSC-VVRNTR-LSQ-EKE-S---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--N----------------P----WMV-SLGVT-LVV-----LLGAFALS--
V-----YLFKLKGKCWSRTYR--------E-----------QGSMGNK-----AVV----
--------L-HKDRT---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------LCKKY-R------------------YPPPKYKPNVT---L--D-PDTAH
PNLV----------LS-----EDGKRVRRAET----K--QP-R------------PDT--
PERFDSWACAL-----------GREGFT---SGRHY---WE-VE-V--GD----GQYWRM
GVARESVS-R--K-GW--------------------------------------------
---------------ISLSPKGGIWAVR-R--R--------GDQFQALTDP-E-----TP
---------------------------------LPLS-PPR---RIRVCLDCDRGQVTFI
DAGSEAP--IFTFPRGSLPG-ERIRPWLWVWSG--S-------QLSLC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
-LLLSLRA-------------------------------------------LVSAQ-FTV
--------M-GPA-VPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---R-AVF
VYKGGRQRTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GFGSKP-----------------LI-
------EIKIQEDG-SI-R---L--ECISRGWYPEPLTVWRDPCG-EVVPALK-------
--------------------------EI-STPDTDGLFMVTTAVIIR-----D--RSVR-
NMSC-SINNTL-LGQ-EKESV-------IFIP-ESFMP-------STSPWMVALAI----
------------------------------------------------------------
------------------------------------------------------------
----ILAT--S----------------P----WTV-ALAII-LAIFIIF-----VAV--S
I-----SCIKKLQRERKILLSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QS-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVLVWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------FLLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSIF-S-VPMRPFFRLGSDDSP-------I-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHHSPQDQFPGLTAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------VMKLQ--FS---YIS--------GYC------GC
FFFLQ--V------------------------------------------MMSSEN-LMV
--------T-TPT-GHLVARVGGQAELSCQVSPPRSVESM-EVRWLRSDN-Y---K-LVY
QYRGGHGVNGE----AAPEYVNRTEF-VKEAIGKGRV-ALRIHNIRISDEGPYRCL--FN
-D-R--GFSDVV-SMN------L--S-VA-----ALGLKT-----------------QI-
------HVESPDYD-GP-S---V--GCFTEGWFPRPRMEWRDSQG-EVVPF-S-------
------S-------------------IS-YSQDEDRFFRMRMTLLLR-----N--QSQK-
SITC-CVLNPL-TGE-EKQTN-------LILS-RHESG-------CKKK-----------
------------------------------------------------------------
-LNILDIASMILQFLC--FI---VFSGIIFYNYLQLRNK---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------KPVLVQLGAEVELSCQLSPPQNAQHM-EIRWFRNRY-K---Q-PVY
LYKDGRDLHAE----IVSRYVERTEL-VKEAIGEGKV-TLRIFNVSAEDDGKYHCS--XX
-X-X--XXXXXX-XXX------X--X-XX-----XTSLEI-----------------QL-
------LLYPPNIK-GI-M---V--ECNSRGWFPEPEMEWRDSRG-ELIAP-T-------
------S-------------------KS-VSQDRDKLFSMHMTLLLN-----S--SSYG-
NITC-CLRNPV-TGR-EERTS-------LVLS-GEIC-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------WKQHLSLGF-----S--------LVSFQVC--LQ
LTGFLTPV---SVS---------------------------------------TDN-FLV
--------M-GPL-DPIVAVLGGDAVLPCFLSPAMNAESM-ELRWFRSKF-S---D-VVF
AYQNQQEQNEE----QMAQYAGRTSL-VSDFLTQGKA-AVQIYKVQASDRGLYTCF--FK
-K-G--AFYEEA-TLE------L--K-VA-----GVGSAP-----------------EV-
------RIDGPEDD-GI-R---V--VCTASGWFPKPRVRWRHLSG-ENFLA-F-------
------S-------------------EA-HAQDAEELFSVEATLVVR-----D--SSAG-
NVTC-SIFNPI-LGQ-EKVAA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKS-VFVVS-MVM-----LGLLLFGA--
G-----YFIQRERSTKLQVQQ--------ERQRLRQA-KEKDQKAKEEA-LQTV------
------------GA-LQ----EELT-----WRKAQL--YA-GGSS---LFAIHH------
------------------------------------------------------------
------------------------------------------------------------
--------------HW-RT------EQFQAW-------------SII---L--N-PGSAH
SNLA----------IS-----PDKRTLTWKD-TC--S-----------------------
--DSNAYSSVL-----------GLEGIT---SGRVY---WE-VE-VKNGD-CS---LWTL
GVCREDVK-R--T-DW--------------------------------------------
---------------YKESPDKGFWVMG-H--F--------EVGYCACTKPDT------Q
---------------------------------LRLQQVPH---RVGVFLDYGEGDVSFF
NMNDGSH--IFSFPPASF-S-GTLFPYFMFRSGD-L-------SMTVC-SV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------L
SVFLFRVF-------------------------------------------WCIAQ-FKV
--------L-GPD-QPVTAVVDGEIVLLCHLNPRKNAENM-EVTWFRSQL-S---P-FVH
RYSAGKDEYGQ----QMPEYQGRTEL-LRDGLPSGSV-ALRISRVRLSDEGQYSCF--VQ
-D-G--SNYEEA-LLE------L--K-VA-----ASGSAP-----------------HI-
------SVEDYQDG-GI-R---V--VCRSARWYPEPEVLWRDHRG-QPLPS-F-------
------S-------------------PT-KTQVASHLYEIQTSIIIT-----E--DSNP-
NFSC-LVRNTR-LSQ-EKEST---L---FY-P-K--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--N----------------P----WIV-VTCVV-LVA-----LAGSFGLS--
A-----YFFKIKDQCVVQDTL--------VSR--MQKTVTFACTDRES----GMDL----
--------K-----GGNEAMERQA---AELRKC---------------------------
------------------------------------------------------------
---------------------H--------------------------------------
--------SSLATCRW-KLFLL--------------PPLPLPAAKVT---L--D-PNTAH
RNLI----------LS-----QDGKHVSWAGT----R--QD-L------------PDN--
PERFDTDLSVL-----------CCEGFA---SGTHC---WE-VE-AKVGD----GIYWAV
GVARESVG-R--K-GK--------------------------------------------
---------------MSHKPEEGIWAVK-W--W--------GDHIKVLTSP-E-----TL
---------------------------------LPLKQAPS---RIRVCLDCDRGQVAFF
DADAKAQ--IFTFPPGSI------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FHV
--------N-GPV-QPVLVMMGEDATFFCYLSPKINAESM-EVRFFKNQM-G---A-VVH
LYKHGEEPDEE----QLQEYRGRTQL-VRDNITEGRV-ALRLERVTPSDSGLYSCG--FH
-S-E--IYYSET-TWV------L--Q-VA-----ALGSAP-----------------LI-
------SVQYSRIW-GI-W---V--MCRSRGWYPKPSVQWGDFTL-RL-SA-P-------
------E-------------------PT-VLEDSSGLFYTETSLLLR-----E--KPKG-
NISC-SIQNHL-LGQ-EKKSI-------VEIA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
W---LMSP--C----------------P----W---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----VMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEP-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENCYKHA-----LLR---HFT-CLF-------
-VLAQLLT---WVS---------------------------------------TKE-FLV
--------F-GPS-EPIVAAPGGEAILPCSLFPVMSVENMEELRWFRSRF-S---E-AVF
VYRDQEEKKEE----QLAEYSGRTWL-VKDQFHQGKA-AVRIRNVQVSDSGIYVCF--FK
-R-G--LFYEEA-ILE------L--R-VA-----VMGSVP-----------------EV-
------HIKGPEDG-GV-C---V--VCMTSGWHPKPQVQWRDSRG-ERLPA-S-------
------S-------------------EN-HIEDDEGLFSMKTTLVVR-----D--SSLG-
NVTC-STFNPI-LGQ-EKAMA-------MFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WMP-AFAVS-VTM-----MGLLVLGS--
C-----CLFRREHSSKLQLRQ--------EWENLRRE-QEPFQKKKEA------------
-------------A--LKTTMCEIP------------------HM---TCSFLV----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQAW-------------SVT---L--D-PDSAH
ANLA----------IS-----QDRMSVTKKDTDM--H-----------------------
---LDGPFSVL-----------GTEGIS---SGRHY---WE-VK-IKNGY-SS---KWTL
GVWREDVE-K--Q-GW--------------------------------------------
---------------YSECPKRGFWTVG-R--T--------SSGYWAYIDSGR-----AS
---------------------------------LSLRQVPQ---SVGVFVDYSEGDISFY
NMSDMSH--IFSFHEASF-S-GTLFPYFRLESGD-V-------SMILS-SEE-FPVPI--
--------------------------------SIL--------PSLKESLC-SQREGLTL
GSRVVDSLPEEESQ---FLPLPSDTL--PP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDKCCKHA-----LLR---RVT-CLF-------
-VLAQLLT---RAS---------------------------------------TDE-FWV
--------S-GPS-DPIVAELGGEAILPCSLSPAMSVENMEELRWYRTRF-L---E-AVF
VYRNQQEQKEE----QMDEYLGRTSL-VKDQFHQGKA-AVRIHKVWLSDSGTYICF--FK
-Q-G--PYYEEA-LLE------L--K-V--------------------------------
--------AGIEDG-GV-C---V--VCNASGWYPKPQVQWRDSRG-ENLPA-S-------
------S-------------------ET-HTEDAEGLFSMESTLVVR-----D--RSLG-
SVTC-STFNPI-LGQ-EKAMA-------MFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FLQA--S----------------P----WMA-AFAVG-MTV-----MGLLVLAS--
C-----CFLIWEQRARMQVHQ--------ELENLLRE-QEEWQKTKEH------------
-------------A--LKTA----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------L-SLS-----PDL-----PFLSLLFS--CW
CFFSSCLS-------------------------------------------PFYRQ-FQV
--------T-GPT-QPVLVMMGEDAMFFCHLSPKTDAETM-EVKFFRTQI-R---A-VMH
LYKNGKELDEE----QQQEYRGRTRL-MRDAIAEGRM-ELRLKRVTLTDAGTYGCG--FS
-S-Q--AFYSET-TWE------L--Q-VA-----GSGRSF-----------------LCL
EPLMVSPVRGRREP-GH-H---Q--RALTPGWPVLQEKI---SVG-RPS-P-T-------
------E-------------------PT-IKEDSRGLYHTITSLLLQ-----E--KPNG-
NISC-SVQNSL-LNQ-EKES----V---LELQ-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---IL-S--K----------------P----WL--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

-------------------------------------MVDFPGYSLSGL---IASFFFIL
LTMKQSDDFRVIGPAHP-ILARVGEDVLLTCQLLPKRTAMHMEVRWYRSEPSTPV-FTHR
DGVEVTEMQMEEYKGRVEWIED-GIAEGSVALKIYNIQPYDNGQYWCHFQDGNYCGETSL
LLKVAGLGSAPNIHME---------GS---GE---------------------------S
GVQLVCTTRGWF----------PEPQ---VY---WEDIQGEKL-----------------
-LAVSEHHIQDED--------------------------------G------------LF
YVETTLVVKNAS----------------------------------AESVSCFIYN----
PVLSEEKG------------------------------AVI--SIPEK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCYLSPKANARSM-EVRWVRSHR-Y---P-AVH
VYKDGDHVAGE----HMAEYRGRTVL-VSDTIDDGRL-TLQILSARPSDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGRKDG-EM-Q---L--ICSSDGWFPQPHIQWRDMQG-KTIPSSS-------
--------------------------EA-LTQGSHGLFHVETLLQVT-----N--ISTV-
NVTC-SISIPF-LGE-EKRAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------WKTLFILGL-LLAVA-------------
V-----GLLRRRG-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT--EV---LLV--------IHC------VV
LYLPQ-MV------------------------------------------ALSSEK-FTV
--------T-GLT-RPVLTPLGGTLELSCQLSPPQQAQHM-EIRWFRNHY-T---Q-PVY
LYRDGKDLHGE----TISKYVERTEL-LKDAIGEGKV-TLRIFNVTADDDGPYHCI--FK
-D-G--EFYEEH-ITE------V--K-VT-----VSSSNI-----------------QI-
------LMHSPNIK-GV-M---L--ECHSGGWFPQPRMEWRDSKG-EIIPA-T-------
------S-------------------KS-HSRNGNKLFNMTMALFIK-----A--NSHR-
NVTC-YLQNHL-THQ-EESIS-------IVLS-GELFS-------WRSIWIRILSIIACV
LVP-FLLTSCVQQ-HLT-------------------------------------------
-----------------------------------------------------CVSVSDP
H---FELD--T--------------------LWL-EDISV-ILYV-MIV-FIIKLV-S--
F-----IYFRLQGKC--------------D------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVPT
------------------------------N------SCLL---------VCL-----LT
LTVLQLPM------------------------------------------LDSAAP-FDV
--------T-APQ-EPVLALVGSDAELTCGFSPNARSEYM-ELLWFRQTR-S---P-AVL
LYRDGQEQEGQ----QMTEYRGRATL-ATAGLLDGRA-TLLIRGVRVSDQGEYRCL--FK
-D-ND--DFEEA-AVH------L--K-VA-----AVGSDP-----------------QI-
------SVTVQENG-DM-E---L--ECTSSGWYPEPQVQWRTADR-EMLPS-T-------
------S-------------------ES-KKHNEEGLLTVAASMMVR-----D--SSIK-
NMS C-CIQNIL-LGQ-GKEVE-------IALP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WII-AVAMI-LLV-----LGFLTIGS--
I-----FFTWKLYKERSGLRK--------KEFGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FI---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGSPR---RVGVFLDYEAGDISFY
NMSDGSL--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-STA-NGPEKVT
VIAN----V------------------------QD-----------DIPLS---PLGEGS
ASGDRDT---LHSK---LIPFSPSQA--P-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLCIS-----PQGALLF-----
LLFLSAFG-------------------------------------------QLSAQ-FTV
--------V-GPP-EPVLAMVGESSTLRCHLYPEMSAEAM-EVRWFRTHF-S---D-TVL
VYREGQEWPEE----QIQQYHGRTSL-EEAGLAWGRV-ALVIHNVTAHEDGDYSCS--VQ
-E-G--TSYEEA-IVH------L--E-VA-----GLGSKP-----------------LV-
------EMKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG-EVVPALE-------
--------------------------EA-YTAGADGLFTVALAVIIR-----D--NSVR-
NMFC-SIHNTR-LGQ-EVAAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVI-LPTLILL-----MAG--G
V-----YLVKKLQKEKEV-LAVENEVLA-VEKEVEREEKETAWKKLR-------------
------------------------------------------------EERL--------
------------------------------------------------------------
-------------TE---------------------------------------------
-------EQLQDELGW--------------------RRTVLHAADVV---L--D-PATAH
PELF----------LS-----EDRRSVFR--STRR----QE-V------------PDE--
SERFDRWPCVL-----------GLERFS---SGRHY---WE-VE-V------EDVMFCAV
GVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGGGVWALELL-----------GGQYCPLAGPAL------L
---------------------------------LPLQERLG---RVGVFLDYEAGDVSFY
NVRDRSH--IYTCPRSAF-A-GPLRPFLLLWSHDSP-------L-AVC-PAF-VGAQGVM
VPE--------DGLVLHAAGARRG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------ASG-LSV
--------E-GQA-EPVVAPLGADASLPCRLAPEQSMAHM-SIRWYRGQP-S---R-AVL
VFRQGQEQVGE----QMLEYRGRAEL-LRDAVGSGSV-ALLLRRVRASDDGLYHCR--FE
-D-G--DVSQEA-LVQ------L--N-VV-----GLGSAP-----------------QV-
------HMTGPKEG-GI-Q---V--LCSSSGWFPRPTLQWTDTTG-RKLPS-L-------
------P-------------------ES-HTQQEDGLFHVDASLVVT-----D--SSLG-
NLTC-SIQNPL-SGQ-EKTST-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--S----------------A----WKL-ALAGT-LPI-----LGLLLIGI--
S-----YAGWREHQNKEKQIK--------EKEKEDNE-AKHMSREKELV-LQAK------
------------GK-----LEAELE-----WRRKLY--NQ--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EHFKP-------------APVI---P--K-HQMIQ
SNNS----------DP-----ESK------ENCR--DETQE-L------------PLSDK
--QGDGNLITL-----------GQEGFL---WKRHY---WE-VD-VEKVE------EWTV
GICEVPSD-G--P-ES--------------------------------------------
---------------FEEPSRKTFRVLV-K--K--------GDEYKALACCSKNIFLEKH
---------------------------------VSVEKRPC---KIMLFLDIEDSDISFY
NMTDGSH--I--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-TVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTTQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPALK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEI-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------ARW--------------------RRTVLHAADVI---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYQALSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLRVS-----PQGALLF-----
LLFLSAFG-------------------------------------------QLSAQ-FTV
--------V-GPP-EPVLAMVGESSTLRCHLYPEKSAEAM-EVRWFRTHF-S---P-AVL
VYRGGRERPEE----QMQQYRGRTSL-EGAGLGRGHA-ALVIHNVTAHEDGDYRCY--FQ
-E-G--MSYDEA-IVR------L--E-VA-----GLGSRP-----------------LV-
------EMKGQEDG-GI-R---V--ECTSAGWYPQPHAVWRDPYG-EVVPTLE-------
--------------------------EA-YTAGADGLFTVTLAVIIR-----D--YSVR-
NMFC-SISNTR-LSQ-EVEAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVF-LPTLILL-----MAG--G
V-----YLVKKLQKEKEV-LA--------VEKEVERKEKEIAWKKLW-------------
------------------------------------------------EERLT-------
------------------------------------------------------------
-----------E------V-----------------------------------------
----SFAKQHQEELRW--------------------RRTVLHAVMTF---K--I-SN---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---N---------------------------------SCLS---------RYL-----LI
FMLLQLPK------------------------------------------LDSAAY-FDV
--------I-GPQ-EPILAVVGTDTQLPCHLSPNMSAEHM-ELRWFRQTL-S---P-AVF
LYQNQQEQVRE----QMPEYQGRVTL-VKDNITTGHA-AVRIHGVRASDDGEYRCF--FR
-E-NE--SYEEA-IVH------L--K-VA-----ALGSDP-----------------HI-
------SMEVQDSG-QV-Q---L--ECTSVGWYPEPQVQWRTPTG-ETLSS-R-------
------S-------------------VS-KNPDEEGLFTVVASVIIG-----S--NSIE-
NVSC-SIQNLL-LGQ-EKEAR-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WIV-SVAVV-LIV-----LGLLTIGS--
I-----FFIWRLYKER--ERT--------SKFSST-------------------------
-------------------------------EKLLE-EL---KWK---KATLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PDK--
PERFDSWPCVL-----------GRET FT---SGS HY---WE-VE-V------GDRTDWAI
GVCRENVI-K--K-GS--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNRYWALTAL-R-----TP
---------------------------------LPLAGSPR---RVGIFLDYESGDISFY
NMTDGSQ--IYTFPSTSF-S-GPLRPFFCLWSCG-------EKPLTIC-PVA-NRPEGVI
VVAN----S------------------------QD--------LSKDIPLS---PVGEDS
ASGDTDT---LHSK---LIPSQSNQG--LP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FRV
--------V-GPD-HPVPAVVGKDALLPCQLLPQMSAEDM-EVRWFISLQPS---E-VIH
LYKDRRDHEEQ----QNVGFRGRTEL-LKDDIANGSV-ALRIHSITPTDEGLYSCF--FQ
-S-S--TFYAEA-KLE------L--T-VA-----GLGSAP-----------------HI-
------FIEGYQDG-GI-R---F--VCQSSGWYPEPKMQWKDRHG-QLLKS-S-------
------S-------------------EE-TSRQPDGLFQTQISIVVA-----E--NSNG-
NMSC-CVRNPR-LNI-EKES----V---IHIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPRT--S----------------P----WMV-TVIVI-LVI-----LASIILPA--
S-----FYFWNHRKKSKNKKK--------SKAESDPK-----------------------
------------------SSINVV---VLLG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KLLAELGW-SKVRQYAV-----WFAPNTWILSPHPVVVT---M--D-PNTAS
SRLY----------VP-----EDGKSVKWRVS----Q--PD-V------------PDN--
PERFDCETCVL-----------GCEGIT---AGRHY---WE-AE-V--GQ----GRVWAV
GVANKSVR-R--K-GW--------------------------------------------
---------------IKFSPEEGIWAMD-Q--C--------GGHYRTCTNP-E-----NF
---------------------------------LSIKVIPK---KIGVFLDYEAGWVSFY
DGVNEAP--IYRFTD-TF-T-ETVFPFF--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDYSRCS-----G--------LSHLTIL----
LLLLPLPT---GGS---------------------------------------TET-FRV
--------I-GPL-HPIVAVLGGEAVLPCSLFPAVSAEDM-ELRWFRSKL-L---E-AVF
VYQNRQEQKEE----QMALYAGRTSL-VGDLLSQGYA-AVRIQRVQASDNGLYTCF--FR
-K-G--HFYEKA-GLE------L--K-VA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDVSG-EKFLA-F-------
------S-------------------EA-HTQDAEGLFSVEAALVVR-----D--SSVG-
NVTC-SILNPV-LGQ-EEAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFSVS-LTV-----LVILLLGA--
G-----CYTKREHSTKVQEMR--------EKETLCQT-REQDRQTKEEE-LKDA------
------------AK-LQ----EELE-----RRKSAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EEFQEW-------------PVT---L--D-PGSAH
SDLV----------IS-----HEKTTVTLKAS-C--V-----------------------
--TSGDTCSVL-----------GFEGIT---SGRCY---WE-VE-IRDGD-QS---EWAL
GVCREGVN-R--K-GW--------------------------------------------
---------------YVESSDKGFWVVG-R--Y--------EEGYCACTVPQT------V
---------------------------------LPLMQGPHPRLRVGVFLDHQEGDISFY
NMTDGSH--IFSFPQISF-S-GTLFPYFKIRSGD-V-------SLTVC-PKV-GGSEGLP
VSLS----N------------------------P----------SLKEPVSLPG-AGFSS
GSGADS-PPGAESP---LLPCNPKAV--SP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVSFPGLS-----PA------G-SL-LP-----
-LLLLVST---QCS--------------------------------------TVSG-FSV
--------N-GPA-EPIMALLGEDVTLPCQLYPEQSAAHM-HIWWYRAQI-S---P-AVL
VVQNGQEQSGE----QMLEYRGRTKL-VGDSISQGHV-ALLIQHVKASDNGQYRCR--FQ
-D-G--DISQEA-IIE------L--N-VI-----GLGSIP-----------------HV-
------HMTGLKEG-GI-Q---V--LCSSGGWFPSPKVQWKDMAG-AKLPS-L-------
------S-------------------ES-QTQDWDGLFHVKSSLVVT-----D--SSLS-
NVTC-SIQNPL-SGQ-EKVSS-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRM--S----------------P----WKA-ALAGT-VPV-----LVLLLIGI--
S-----YIGWKEHQAKDREIE--------EKEKESQE-IQRIRNDKEKA-LKI-------
-----------------------------------------RDWK---KALIYP------
------------------------------------------------------------
------------------------------------------------------------
--------------G-----------KLIM-------------APVN---L--N-HELFH
QNNS----------DP-----KR-----------------------------------KK
--DGDCNLLTL-----------DGKGFT---TGRYY---WE-VD-VEDND------EWVL
GVYETNEE-K--M-AP--------------------------------------------
---------------LKKPSMKKFRVLE-K--K--------KGEFRALACDSQKVLLEEP
---------------------------------L-TEECPQ---KIVVFLDYEDNDISFY
NMINGMH--IFSFTQDKF-S-AILYPYFKLKSME-L-------SPSA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MERPPSTS-----G-----SWLLGCLL-----T
LAFLQLPA-------------------------------------------PV-------
--------S-GDADKYYHVPLGGTAELSCPLLLWPGMVLS-EVRWQ---HLPHT-Q-AVH
VLRDGQDSDED----LMPEYKGRTKL-VRDT-HKGSY-TLHISNVRLEDRGLYQCQ--FR
-V-G--NQSQEG-NVT------L--Q-VA-----VLGSDP-----------------FI-
------HVKSYDAG-WI-Q---L--VCQSMGWFPKPWTEWRDTEG-RVLQSLT-------
--------------------------EA-HSLDETALFQTAVSSRVR-----D--NAVG-
NVSC-TVRNEV-LGQ-EKTTI--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------GAPAPGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLLILLG--
I-----WLICKQKRSKGVLFAF--PFLCLE-NLLEDHAKEK-GM----------------
---------------------------------YR-------------M-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------RMVVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDK----K--RP-V------------PDN--
PQRFDFVVSVL-----------GSES FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RRNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---RNTAPLIIC-TEL-QKSDESI
VTKQ---------------------------------------------------EGKS-
-QANGDVSLTVNPS---LLSPQGSKL--FPVN---DT---WPSNLGPALQGFKAPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FVGFLKEV-------PWCRS------IFF-THFLL--
--ILCLGE------------------------------------------VD-SDE-VKV
--------V-GPG-DSMLALVGETAEFPCHLSPYQDAEHM-EIRWFRTQV-S---N-VVY
LYQEQQGLSDT----QMPEFRNRTVF-EANDIMDGSV-TLHVLSVTPSDEGQYGCR--FL
-S-H--NFSGEA-MWE------L--E-VA-----GLGSDP-----------------LI-
------SLEGFNEG-GI-R---L--RCSSSGWYPKPKVQWRDHRG-QCLPP-E-------
------Y-------------------EA-IIRNAQGLFSLNTSVTVR-----G--GAHS-
NVSC-SIQNPL-LAQ-KKEFV-------LQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRT--S----------------P----WKK-AFLVT-LAA-LPLSLAVLTILA--
L-----QYFYKKRCSQEKLRK--------QEEK-DRE-----------------------
------------------RLQAEL----DWRRSEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTTAH
LSLE----------IS-----DDLKSVSSR---LGAP--SI-V------------VHG--
PQRFSEQTCVL-----------SRER FC---SG RHY---WE-VN-V------GRRSRWFL
GACLESVE-R--S-GS--------------------------------------------
---------------VRLSPAAGYWVMGLW--N--------SCEYFVLDPQ-R------V
--------------------------------ALTLRVPPR---RVGILLDYEAGKLSFF
NASDGSH--VFTFTDTF--F-GALCAYFRPRAHDGS---EHPDPLTIC-SLP-VKGPHVL
EED------DNDNWLQ----------------------------PY-EPF----------
-----DPAWADDEA---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLLL--LL
LLLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-NPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRITF-VSNDINRGSV-ALVIHNVTAQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LT-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRDPYG-EVVPTLK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KYVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------SASPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTA--S----------------P----WMV-SMTVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKKVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRHSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-T-VPVRPFFRLGSDDSP-------I-YIC-PAL-TGANGVM
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAAPT
------------------------------N------FCLL---------VCL-----LT
LTVLQLPT------------------------------------------LDSAAP-FDV
--------T-APQ-EPVLALVGSDAELTCGFSPNASSEYM-ELLWFRQAR-S---P-AVL
LYRDGQEQEGQ----QMTEYRGRATL-ATAGLLDGRA-TLLIRDVRVSDQGEYRCL--FK
-D-ND--DFEEA-AVY------L--K-VA-----AVGSDP-----------------QI-
------SMTVQENG-EM-E---L--ECTSSGWYPEPQVQWRTANR-EMLPS-T-------
------S-------------------ES-KKHNEEGLFTV AVSMMIR-----D--SSIK-
NMSC-CIQNIL-VGQ-GKEVE-------ISLP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAII-LLA-----LGFLTIGS--
I-----FFTWKLYKERSSLRK--------KEFGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TS
---------------------------------LRLAGPPR---RVGVFLDYDAGDISFY
NMSNGSL--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-STV-NGPEKVT
VIAN----V------------------------QD-----------DIPLS---PLGESS
ASGARDT---LHSK---LIPFSPSQA--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGICCQHA-----LLF---QFT-CLL-------
-VLEEL-------------------------------------------------E-FAV
--------F-GPS-HPVVAELGGEAVLPCSVSPAVSLESMEELRWFRARF-S---E-AVF
VYRNQQEQEGE----QLAEFSGRTSL-VKDQFVEGRA-AVRIHKVWTPDSGAYICL--FK
-Q-G--VFYAEA-ILE------L--K-VA-----VMGSVP-----------------EV-
------YIKGSEDG-GV-C---V--VCRASGWYPKPQVQWRDSRG-ETLPA-S-------
------P-------------------ET-HSEGAEGLFTVETSMVVR-----N--SSLG-
NVTC-SASNPT-LGQ-EKAMA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQT--S----------------P----WVP-AFAIT-MTV-----MGLLVLGS--
C-----CLLRRERCSRRQLRQ--------ERERLQSE-KQASQATTEET-Q---------
------------MT--TRTLHRELD-----RRKAA-----------------YM----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQA------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MVL--VL
ALALSLL-------------------------------------------KLGSGQ-WQV
--------I-GPN-KPVQALVGEDVVFSCFLSPETNAEAM-EVRIFRDQF-S---A-IIH
LYQDGKDQDYM----QKPSYRGRTEL-MKDFIADGHV-SLRLKKVTALDAGLYGCW--FS
SQ----TYDQGT-TWE------L--Q-VS-----EMGSAP-----------------LI-
------SLTGFVDG-GI-R---L--LCQSSGWFSQPTVKWKGPQG-HDIPSDS-------
---------------------------K-VNVDRHGLFDVETSLTLQ-----E--N-LG-
SISC-SVQLTD-QSP-EVTSS-------IWLG-EMFFQR---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WLL-AFISLTPLC---IGISVGIIGM--
-----KILFSKSQGK----IQ--------KKL----------------------------
------------------------------------------EWR---KKHR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QADLKEVRKYAVEVT---L--D-PDTAH
PQLH----------VA-----D-LKTVCYTNV----P--QE-V------------PHS--
EKRFT-RMCVV-----------ASQGFQ---AGKHY---WE-VG-V------RHNKRWHL
GVCRDDVD-R--T-RNN-------------------------------------------
---------------VILSPDNGYWVLGLE--M--------DW-HFTLNPH-R-----IN
---------------------------------LSLRNTLL---QVGVFLDYEGGTISFF
NINDQSP--IY-TMTHRFEG-L-LRPYIQHEAYE-D---ENVTPIVIC-PV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEHGCRP-------------SLLCSLPSL----
LLLAQLPT---WGS---------------------------------------ADE-FQV
--------I-AST-VPIVAMLGGDAVMPCYLFPPMNAEDM-ELRWFRTKF-S---D-AVF
VYRNHREQHKE----QMPQYIGRTFL-VRDLLTQGQA-AVHIQKVQASDNGTYTCL--FQ
-K-G--GRYAEG-ILA------L--K-VA-----GLGSAP-----------------QV-
------HIEGLEQD-GV-R---V--VCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKATA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFVGS-LTV-----LGLLLFGA--
G-----CFTRREHSAKVQERE--------KH------------RAKEED-LNAR------
------------DD-LQ----AELG-----RRKTAY--L--VAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ERFQAW-------------SVT---L--D-PSSAH
RNLT----------VS-----PERKSVSCQA-VP--E-----------------------
--SSEDIYSVL-----------GLEGIT---SGRCY---WE-VE-IRSER-FG---DWVL
GVCMEHVT-S--T-GW--------------------------------------------
---------------CRESPDEGIWVVS-S--F--------YSSYLAWTKP-Q-----QL
---------------------------------LSLQQTPC---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFPPASF-S-GTLYPCFMLR-GD-M-------TLSIC-PTE-RGSEGLP
VPLS----K------------------------SP---------SLEEAGRPPG-EGLSS
GSGVDGAPPGAESP---LLSRRAQEL--SCLM-----IMRT-A-----------------
------------------------------------------------------------
-----------SSCLCSDSRRCKFTAV---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLHSC-----LLASLVF-----
FLVLSLYV-------------------------------------------MVSAQ-FTV
--------L-GPA-EPILAMVGENTTLYCHLSPERNAEDM-EVRWFRWRL-S---P-AVL
VYKDHQEREEE----QMAAYQGRTTF-VSTDISKGRV-ALIIHNVTAYDNGIYYCY--FQ
-E-G--RSYDQA-IMR------L--M-VA-----SLGSKP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYY-EIVPALE-------
--------------------------EE-CTADRGGLFTVTMTVIIR-----D---SVR-
NMTC-SVNNTL-LNQ-EMESV-------IFIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AMAVT-LPVLMLILL---TSG--S
I-----CLVKKHHRKKSI-LS---------------PEKEVEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ENARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVRR--GASR----QS-V------------PDN--
PERFDCQPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPET------I
---------------------------------IPLKERLH---RVAIFLDWEAGDVSFY
NTRDRSH--IYTCPPVAF-A-GPLRPFFRLGSDDSP-------L-FVC-PAF-TGAQGVI
IPE--------GGLILYRTRPVCQSHVKEP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGV---IASFFFIL
LTMKQSDDLRVIGPAHP-ILVRVGEDVLLTCQLLPKRTAMHMEVRWYRSEPSTPV-FMHR
DGVEVTEMQMEEYKGRVELIEN-GIANGSVALKIYNIQPSDNGQYWCHFQDGNYCGETSL
LLEVAGLGSAPNIHME---------GS---GE---------------------------S
GVRLVCTTRGWF----------PEPQ---VF---WEDIQGEKL-----------------
-LAVSEHHIQDED--------------------------------G------------LF
YVETTLVVENVS----------------------------------AESVSCFIYN----
PVLSEEKG------------------------------SVI--SIPEK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCYLSPKANAQSM-EVRWVRSHL-Y---P-AVH
VYKDGDHVAGE----QMAEYRGRTVL-VSDAIDEGKL-TLQVLSARPSDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGRKDG-EM-Q---L--MCSSDGWFPQPHVQWRDMQG-NTIPSSS-------
--------------------------EA-LTQGSHGLFHVETLLWVT-----N--ISTV-
NVTC-SISIPF-LGE-EKRAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
V---------F---------------------WKTLLILGL-LLAVA-------------
I-----GLLRRRS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------CFL----------TFFLHTFLVY
HVLVH-------------------------------------------PLTPCSAQ-FAV
--------H-GPP-GPILAMVGEDADLPCHLSPSMNAETM-ELRWVRSSL-R---Q-VVN
MYADGKEVEDK----QSAEYQGRTSI-LRNNITAGKA-ALRIYNVRASDSGNYLCY--FQ
-D-D--NFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVRSYEDG-GI-H---L--ECRSTGWYPQPQIQWKDAKG-ENTPAT--------
--------------------------AAPVVADRVGLYAVAASVIMR-----G--SSGE-
GLSC-IIRNSL-LGQ-EKTAR-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------EP
F---FMNS--E----------------P----WIK-ALAGT-LPV-----LLLLLAGA--
S-----YFLWRQQKENNAL---------TKETEREQMLKEKEYAATE-------------
----------------QEKS---------TR-----------EWR---RIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----RKHI------------------------------LKLSTADVL---L--D-PETAN
PILI----------VS-----EDQRSVQRAEE----P--QN-L------------PDI--
PERFDWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCWRNVE-R---KGW--------------------------------------------
---------------VKMTPENGYWTMGLS--D--------GYNYRALTEP-R-----TK
---------------------------------LTLDKAPT---RVGVFLDYETGEVSFY
NAMDGSH--IYTFLHTSF-S-EPLCPVFRILTLEPT-------ALTIC-PAA-KEVWHSL
-V--P--D-----------------------LVPD--------SSQETPVT------LGL
SEQSGEPQAEVQSL---LLPLQSGA-EEQQIT--------T-I----KLHAHNEALY---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------RMVDSCRVS-----PA--------SSLLPL----
-LLLQVAT---WHS-------------------------------------AAASE-FSV
--------K-GQA-EPIVVPLGADASLPCRLSPEQSAAHM-YIRWYRVRP-S---P-AGL
VFQNGQEPVGE----QMLEYRGRTEL-LRDAIGKGSV-TLLIRHIRASDDGLYQCH--FK
-D-G--DVSQEA-FVE------L--N-VV-----GVGSEP-----------------HV-
------HMTGPKED-GI-Q---V--LCSSSGWFPKPKVQWRDTAG-RRLPS-L-------
------P-------------------ES-HTQHKDGLFRVDASLVVT-----D--SSLG-
NVTC-SVQNPL-SGQ-EKIST-------IFLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--S----------------V----WKS-ALAGT-FPI-----LGLLLIGI--
S-----YMGWREHEDKKKAIK--------KMKKESHE-RAQMSDEKEYV-LKTK------
------------AE-----LEAALE-----QRKALY--NK--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EHFKP-------------APVI---L--K-HQMTQ
SNSS----------DP-----ENK------ENYR--EETQE-L------------LLSDE
--QGDCSLITL-----------DQEHAM---SERHY---WE-VD-VENAE------EWTA
GIYEVHKD-G--T-GP--------------------------------------------
---------------SKEPLRVNFRVLV-K--K--------GDEYKALAYCSKNVSLEER
---------------------------------VSVEKCPQ---KIMLFLDYGDNDISFY
NMTDGTH--IFSFTQPTF-S-GQLYPYFRLRSME-L-------SPSAK-R----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
--------FQVQGPHEP-MVAMLGGEAMLPCSLVPPQSIKYKKISWTRTLPSQVV-HLYE
DGRDKPEKAMEEYLGRTQLVKN-ILHKGIVVLIILNVQPSDNGQYHCEIQHGSFYSEAVI
ELKV AALGSR PQFHMG---------VT---KS---------------------------R
ELQLECKSEGWF----------PQPK---VQ---WMDSEGEEI-----------------
-PADSETHTQDKG--------------------------------D------------LF
HVTTSLLLREAS----------------------------------QKNLTCSVWN----
PVLNQK KE------------------------------EQF--SIAAR-LQRD-IG AFQV
--------Q-GPH-EPMVAMLGGEAELPCSLEPRQSIKYM-KISWTRTLP-S---Q-VVH
LYEDGWDKPEK----AMEEYLGRTQL-VKNVMHKGIV-VLKILSVQPSDSGQYCCV--IQ
-H---GSFYSEA-VIE------L--K-VA-----ALGSRP-----------------QF-
------HIEVTKSR-EL-R---L--ECKSEGWFPQPKVQWMDSEG-EEIPADS-------
--------------------------ET-HTQDKGGLSHVTTSLLLR-----E--ASQK-
NLTC-SVWNPV-LNQ-KKEEQ-------FSIA-GQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---S---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-C---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKKVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERPRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
TERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSD--IYTFSNVTF-S-GPLRPFFCLWSSG-------KKPLTIC-PIA-DGPERVT
VIAN----A------------------------QD--------LSKEIPLS---PMGEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---S---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-R---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERPRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSD--IYTFSNVTF-S-GPLRPFFCLWSSG-------KKPLTIC-PIA-DGPERVT
VIAN----A------------------------QD--------LSKEIPLC---PIGEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDLPGYSLSGA---IATVFFIT
MTVKQPDNLRVTGPTHP-VLARVKEDALLTCQLLPKRPMRYMEVRWYRSEPGTPV-FMYQ
DGAEVTEMQMEEYGGRVEWIED-GAAEGSVALRIHDIRPSDNGQYWCR FQEGNYCGEASL
LLKVGGVGSA PDIHVE---------GS---VE---------------------------N
GVQLVCTATGWF----------PEPQ---VH---WEDNQGKKL-----------------
-LTASEHHFQDED--------------------------------G------------LY
YVETTLVLRNVS----------------------------------AETVSCVIHN----
PVLNEE KR------------------------------SVI--SLPEK-LQSELAS-LKV
--------I-GSS-HPILVKV GEDTQLTCSLSPKVKARGM-KVRGVRSHR-C---P-AVH
VDVDGEPVAGE----QMAEYRGRTTL-VSDAIDEGRL-TLQIHNATTSDAGQYRCL--FE
-K---DDVVQEA-SLV------L--M-VA-----GLGSNP-----------------LI-
------TKEGLKDG-KV-D---L--MCTSDGWFPEPHVQWRDMEG-KMIPPFS-------
--------------------------VA-LSQGRDGLFHVKTSLLVA-----D--SSVV-
NVAC-AITNPL-LNE-EKNAT-------FSVS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------RKMM-GFL-----RSF-----LSRCLI-----S
LLILQMTV-------------------------------------------CVSEQ-FKV
--------L-GPT-GPIVAILDTDVTLPCRLSPLMNAEHM-DIRWLRSQF-Y---E-AVF
VFQNGREQVGE----QLVEYMGRTEF-ISDFIKEGRV-AVKIYNVKMSDNGEYQCI--FQ
-E-G--DAYEKA-VFE------V--K-VA-----SLGSAP-----------------RF-
------HLEGYENG-GI-R---L--ACTADGWFPQPQVQCRDNRG-GKLPF-L-------
------S-------------------ET-QAQDEAGFFHVKTLIVVQ-----D--SSVR-
NVSC-SIYNPL-LGQ-GKTF----S---ILLL-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKT--S----------------P----WKK-ALIAI-IPV-----VVILLGIS--
I-----FFILKRGKK-IKKLL--------QEKKEDQEYKGKGKK-QSRGKSGN-------
------------------------------------------------------------
---------------F---------------------DQLQDDS----------------
--------------LIIVAFQK--------------------------------------
-----K--------GS-IS------MIQVNWR-----KQHFQALNVT---L--D-PASAH
PGLV----------LS-----RNGKFMRVENA----------------------------
GKSAEETFSVL-----------GREPIT---SGRHY---WE-VK-V--EMEIGNKATWHL
GICRDSAK-R--S-GG--------------------------------------------
---------------FRESPGMGFWAIG-C--S--------DGTFQPMISK-Q-----SV
--------------------------------PPSLGKPPE---QIGIFLDYEAGNVSFY
NMTDGSH--IYNFSRASF-S-GPVRPYFSIQT-LNT-------SFTIC-DVS-DRPESIP
APSL----E------------------------TP--------VT---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MR-----G--SSGD-
RVSC-TIRSSL-LGL-EKTAS-------ISIS----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
V-----YFLWQQREEKKTL---------FRKLKREQELREMAWSTMK-------------
----------------QEQS---------TRVKLLE-E---LSWR---SIQYA-------
------------------------------------------------------------
------------------------------------------------------------
----SRGERHS--------------------AYNDWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCESFT---SGRHY---WE-VE-V------GDRKEWHI
GVCSENVQ-R---KVW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TI
---------------------------------LKLPKPPR---KVGVFLDYETGDISFY
NAVDGSH--IHTFLDISF-S-KPVYPVFRILTLEPT-------ALTIC-PV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPP------ASLHFS-----QATSLLL-----
-PILSLLV-------------------------------------------LVSAQ-FTV
--------M-GPA-GPILAMVGENTTLPCHLSPEKNAENM-EIRWYRSQF-S---P-AVL
LYKGRRERTEE----QMEEYQGRTTF-LSEAISQGKV-GLIIHNVTAHENGMYCCY--FQ
-E-G--RSYDKA-ILH------L--R-VA-----RLGSKP-----------------LI-
------EMKGYEDG-GL-R---L--ECTSSGWYPEPHPVWRDPCG-KVTSALE-------
--------------------------KA-CTVDKDGLFTVTMVVIIR-----D--SWVR-
NMTC-SISNTL-LGQ-EVETV-------IFIP-ESFTP-------SLSPWIAALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAILMLF-----TFG--I
M-----CLIKKFHGGKKS-LSE--------EKDTEYEERE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----ITQQLQ-ELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDGRSVRR--GPSR----QS-L------------PNN--
PERFDCRPCVL-----------GRER FS---SG RHY---WE-VE-V------EDVMVWAI
GVCRDSTE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPMKERLC---RVAVFLDYEAGDVSFY
NMRDSVH--RGPGSHGA-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDLPGYRLSGA---VASFVFVL
FTMKPSDDFRVSGPAHP-ILARVGEDALLTCQLLPKRTAMHMEVRWYRSEPGTPV-FAYR
DGAEVTELQMEEYRGRIEWIED-NIAEGSVAVKMDNIQPSDSGQYWCRFHEGNY YGETSL
LLKVAGLGSAPNIHME---------GP---VE---------------------------T
EVQLVCTAKGWF----------PEPQ---VY---WKDITGEEL-----------------
-LTVSEHHIQDED--------------------------------G------------LF
YVEATLVIRNAS----------------------------------LETVSCFIHN----
H ILNEEKG------------------------------SVI--SIPDK-LQTELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCSLSPKANAQSM-EVRWVRSHR-Y---P-AVY
VYMDGDYVDGE----QMAEYRGRTAL-VSDAIHEGRL-TLQIHNARTSDDGQYRCL--FE
-K---DGVYQEA-NLD------L--K-IV-----GLGSSP-----------------LI-
------TMEGLKDG-ET-Q---L--MCTSEGWFPQPHVQWRDMEG-KTIPSFS-------
--------------------------EV-LTQGSHGLFRVETFLLVT-----N--SSLV-
NVTC-SISNPL-LGE-EKIAT-------FSVS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGA---VASFLFIL
LTMKQSEDFRVIGPAHP-ILARVGEDALLTCQLLPKRTAMHMEVRWYRSEPSTPV-FAHR
DGVEVTEMQMEEYRGRVEWIEN-GIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSL
LLK VAGLGSAPNIHME---------GP---GE---------------------------S
G VQLVCTTRGWF----------PEPQ---VY---WEDIRGEKL-----------------
-LAMSEHHIQDED--------------------------------G------------LF
YVEATLVVRNAS----------------------------------AESVSCFVHN----
PIL TEEKG------------------------------SVI--SLPEK-LQTELAS-LKV
--------I-GPS -KPILVRVGEDIQLTCYLSPKANAQSM-EVRWVRSHR-Y---P-AVH
LYMDGDHVAGE----QMAEYRGRTVL-VSDAIDEGRL-TLQILSARPSDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGQEDG-EM-----L--MCSSDGWFPQPHVQWRDMEG-KTIPSSS-------
--------------------------EA-LTQGSHGLFHVETLLRVT-----N--ISAV-
DVTC-SISISF-LGE-EKIAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------GKTLLVWGL-LLAVA-------------
V-----GLLRKRS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SFL----------AFLLLNFRVC
LLLLQ-------------------------------------------LLMPHSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------DVKGYKDG-GI-H---L--ECRSTGWYPQPQIQWSNNKG-ENIPTV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------R----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWQQQEEKKTQ---------FRKKKREQELREMAWSTMK-------------
----------------QEQS---------TRVKLLE-E---LRWR---SI---Q------
----------------------YASR----------------------------------
------------------------------------------------------------
------GERHS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCES FI---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LKLPKPPK---KVGVFLDYETGDISFY
NAVDGSH--IHTFLDVSF-S-EALYPVFRILTLEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGV---VASFFFVL
LSMKQSDDFRVIGSAHP-TLVMVGEDALLTCQLLPKRTTMHMEVRWYHSELSTPV-FLYR
DGAEVTEMQMEEYRGRVEWIED-NVTEGSVALKIHNIRPSDHGQYWCRFQEGNYCGETSL
LLN VAGLGSD PYIHMD---------GS---VE---------------------------S
GLQLVCTAKGWF----------PEPQ---IS---WQDIRGEKL-----------------
-LTISKHSIQDED--------------------------------G------------LF
YVESTLVVRNVS----------------------------------TEVVSCFIHS----
PTLTEE RG------------------------------SDI--SIPXK-LQTELAS -LKV
--------I-GPS-QPILVRVGEDIQLTCSLSPKTDAQSM-EVRWVRSHR-Y---P-AVY
VYMDGDDVAGE----QMAEYRGRTAL-VSDAINEGRL-TLQINNARTSDDGKYQCL--FE
-K---DGVYQEA-DLD------L--K-II-----GLGSSP-----------------RI-
------SMEALKDG-ET-K---L--KCTSEGWFPQPHVQWRDMEG-KTIPSVS-------
--------------------------QD-LTQGSQGLFHVEAFLLVK-----S--SSVV-
NVTC-SISNPL-LGE-EKMTT-------FSPS-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLP
---V-------------------SLDSLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PS-SE--VEV
--------L-GPE-HPILALVGEEVEFPCHLWPQLDAQQM-EICWFRSHT-L---N-VVH
LYQEQQELPGR----QMQAFRNRTKL-VKDDIAYGSV-VLQLHSIVPSDKGIYGCR--FH
-S-D--NFSGEA-LWE------L--E-VA-----ALGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GALS-
NVSV-SIQNLL-LSQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---VPGA--S----------------P----WKS-AFVAT-----LPPLLLVLAALA--
L-----GVLQKQRRSREKLRK--------QEEK-RQE---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSSR---GAPP--GP-A------------PGH--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------ARLSPAAGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALALRVPPR---RLGVFLDYEAGKLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPE-KPVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQF-S---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRI-SLRLENITVLDAGLYGCR--IS
SQ----SYYQKA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SIAGYVDR-DI-Q---L--LCQSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNRDMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSQ-EVESR-------VQIG-DTFFEP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----QIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----N-LKTVTERKA----P--QD-V------------PHS--
EKRFT-RKSVV-----------ASQ SFQ---AG KHY---WE-VD-G------GHNKRWRV
GVCRDDVD-R--R-KEY-------------------------------------------
---------------VTLSPDHGYWVLRLN--G--------EHLYFTLNPR-F-----IS
---------------------------------VFPRTPPT---KIGVFLDYECGTISFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSYN-E---QNGTPIVIC-PVT-QESEREA
SWQR---------------------------------------------------ASTIP
ETSNSESSSQATTP---FLPRGDV------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EMKGCPTSP-----PA--------GCLLPL----
--LLLAST---GAS-------------------------------------GEVSS-FSV
--------R-GPD-DPIRVLLGTDVTLPCQLSPAQSASHM-HIRWYRAQL-T---P-AVL
VFHDGQEQ--V----QMPEYQGRTRL-VRDAIDTGSV-ALQIRQVQASDDGLYHCQ--VT
-H-G--ATSQEV-TIE------L--R-VT-----GLGSAP-----------------LV-
------RMTGPENN-GI-R---V--SCSSSGWFPKPRVRWRDGAG-EALPS-S-------
------S-------------------EA-QTQDGDGLFHVEASLLVT-----D--RTAG-
KVAC-SIQNPL-HDQ-EEVRA-------IMLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKV-ALFCL-LPV-----LLVLFAGT--
S-----LAAWKQHQAKKQEKK--------EKSEAEQE-TQQMRKEKETA-LKKR------
------------DD-----LQAELD-----RRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQL-------------APVR---I--N-HEMPH
QDKS----------SP-----EAE------ESSR--EETAQ-P------------LLSHP
--RDDHNIITL-----------YQEGFM---LGRYY---WE-VC-VGDTE------EWTL
GVYELSNQ-D--A-P---------------------------------------------
----------------SREPLRKFRVLE-K--K--------GDEYRALTFCSQTVSLEEP
---------------------------------LLLGTRPW---KIAIFLDQEDNDLSFY
NMTDETH--IFSFTQARF-L-GSLYPYFTHNPAD-L-------SPAQS-Q----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKLK--SS---SFS--------GSC------VS
FLLLQ-AM------------------------------------------TSTSEN-WTV
--------T-IPA-RHLVATVGGHAELSCELSPPRSAECM-EVRWFRGDN-S---K-LVH
LYSDGHEVNGD----AAPAYVNRTEF-VKEAIRQGKV-TLRLRNISVSDDGSYQCS--FK
-G-N--GISDVA-SMN------L--S-IA-----ALGLET-----------------QI-
------HVQAPGTE-GL-M---V--DCNSGGWFPKPQMECRDSRG-ERVPH-S-------
------S-------------------KS-YLQDGARLFHMKMTLVLR-----N--QSWG-
NMTC-YICNPL-TGE-EKYIQ-------LLAS-DDLFY-------PNHIWMP--------
--F-SVLLLFVILF-LAIVIMLIC---------------------------------MFL
YDFTGWLSSSIIQLPC--LL---VFPGMLITY-LQFRRQDYY-EIWSS--FRARVSISDP
L---VPLY--N--------------------DWM-WDMAV-VIAF-PMT-FFSLLIIV--
L-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AAP-SPSS-PCSSCR----L-----GKV--RV
CPTEG----------------------------------------------PGEPS-WVA
--------WETGG-RPHPGHRGEDALLPCRLSLNLSMEDM-ELRWYRSRP-S---P-AVY
LHRRGAQVSRE----QMAESRGRTTF-LGDHLARGEA-VLGIHNATVYDNGTYYCL--FR
-D-G--EPHSET-TLA------L--Q-VA-----GLGLEP-----------------RI-
------HVTEDLDK-GI-R---A--ECTSAGWYPEPHVEWRDFRG-YAVPA-V-------
------T-------------------RF-SASATTGLLAVLSRVAVP-----D--RSMG-
GLTC-SISSPL-LHE-RKVA----E---SHLP-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------EC--S--------------------VWLQ-ARVCV-AL----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------FL-LFSFFL-S--FFL---SFF--LS
FFLKQSLT-------------------------------------------SGKAD-FSV
--------F-APD-KPLLAVVGEEVDLPCHLSLNISAEDM-ELRWYRDQP-S---P-AMH
LHKNGIDVQDE----QMAEYQGRTTF-LSTRLAQGQA-AVRIHNVTALDNGTFHCN--FK
-D-G--IMSAET-TLW------L--R-VA-----GLGSEP-----------------KI-
------QVGPGQSE-GV-W---A--QCTSEGWYPEPQVEWRDLGG-QSLPS-V-------
------T-------------------NL-SASPTTGLFSVVSNVTLL-----D--RDVE-
GFSC-SIISSL-LQR-RKVA----K---SYLP-VP-------------------------
------------------------------------------------------------
------------------------------------------------------------
F---YSRV----------------------LPWSA-PL--I-CT-------------P--
K-----ITLQKFFLKKWEHDP--------EKLASMTH--------EETCLLETAG---RK
TSKL--------------------------------------------------------
----------------LSVQKKLEAQG-------HPET----------------------
------------------------------------------------------------
VVTSPRGPGVPSKQEC-R-------------------LGTQTPISPS---L--D-PDTAS
PKLA----------LS-----EDGKNVKWLFF----D--QE-L------------P DI--
LSDSTRT------------------------PVKYY---WV-----------GHRKSWNL
GMCLDILD-P--K-RR--------------------------------------------
---------------IPKASKHRFWALE-L--------------FWALTFL-R-----LR
---------------------------------LYPSEPLH---QVGTLLDCDAGRVSFY
NVGSGSL--IHTFSGLSF-S-VPLRQFFCLWTHDAN-------PLTIC-TEC-QDLEA--
--LG----S------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------E-FLV
--------T-GPT-DPIVAVLGGDATLPCFLSPAMNAEDM-ELRWFRSKF-S---E-AVL
VYQNGQEQNEE----LMPQYAGRTSL-VRDFLSQGEA-AVRIRNIQVSDSGKYTCF--FQ
-K-GD--YYEED-ILE------L--K-VA-----GLGSAP-----------------QV-
------TLKD-EKD-GV-C---V--VCKVSGWFPKPQVQWRDVRG-EVTGV-L-------
------------------------------GPDAAGLFSVEAAVVVR-----D--RSAR-
DVTC-SILNPI-LGQ-EKVMA-------IPIP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------V-SSHPFD------VPGCLFP--TV
LVRRTGLP-------------------------------------------TFPAQ-FTV
--------T-GPE-HPVAASLGGEAVLSCHLSPRMSAESM-EVRWFRSRF-S---E-AVH
VYRDGQDQIGE----QMPEYQGRTEL-LKDNITDGKV-SLRIRDVRPSDDGQYKCL--FQ
-S-K--VYYKEA-LLE------L--E-VA---AVGLGSVP-----------------DI-
------AVEGHQDG-GV-R---L--VCRSSGWFPKPQAEWRDQQG-QHLPS-A-------
------S-------------------ES-SSQEAGGLFGTEIAIVLT-----E--RSSR-
KVSC-RVRNPL-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPN-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQR-F---N-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRL-SLRLGNITALDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWFPRPMAKWKGPQG-QDLSADS-------
---------------------------R-TDTNMHGLFDVELSLTVQ-----E--N-AG-
GVSC-SMQHAH-LSQ-EVESR-------VQLG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WYL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQ-----------------------------------------------
------------------------------------------DWR---RKHR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDAWKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHREA----P--QD-M------------PPS--
EKRFI-RMSVV-----------A SQNFQ---AG RHY---WE-VD-V------GHNQRWYV
GVCRDGVS-R--R-KKN-------------------------------------------
---------------VILSPNHGYWVLGLN--A--------ENLYFTLNPH-F-----IS
---------------------------------LCPRTPLT---QIGVFLDYECGTVSFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSHN-E---QNGTPIVIC-PVT-QESERKV
CWQS---------------------------------------------------ASAIP
ETSNSEFSSQATTP---FLPGSDA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLLL--LL
LLLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-NPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEGYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILR------L--A-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRDPYG-EVVPTLK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KYVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFTP-------SASPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTA--S----------------P----WMV-SMIVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKKVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----DDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRHSAE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-T-VPVRPFFRLGSDDSP-------I-FIC-PAL-TGASGVM
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHGC
LLLVQ-------------------------------------------LLTPCSVC-CA-
----------WTH-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDVTAGKA-ALRIH-VTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIY---------------------
------------------------------GPVA-----LAPSVIMR-----G--RSRE-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRST--Q----------------P----WIA-ALEET-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATN-------------
----------------MAQA---------LHAE---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----ALKSRKN-----------G----------RHY---WE-VE-V------GDRKEWNI
GVCSKNVQ-R---KVW--------------------------------------------
---------------VKMTPENGYWTIGLT--D--------GSKYRALTEA-R-----NN
---------------------------------LKLPEPPK---KVGIFLDHETGDISFY
NATDGSH--IYTFPHTTF-S-EPL-----ILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--D-----------------------LVPD--------HSLETPVA------PGL
ANENGEPRAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------S-FLV
--------I-GPS-EPIVAILGADTVLPCRVSPAMSVENM-ELRWFRSQF-N---E-AVY
VYQNGMEQTEE----QVVDFKGRTEL-VKDFITEGRV-AVRIRSLRVSDNGMYTCF--FK
-R-GS--DFEEA-ILE------L--K-VI-----GLGSGP-----------------YV-
------SMVGPEDG-GI-R---L--ACKGKGWFPQPEIQWKDSRG-EKIAS-L-------
------S-------------------EA-ETQDNDGLFQVEASLIVR-----D--SSKR-
DISC-FLKNPF-FGQ-EKVET-------ISIP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------SSPQF
FSLP-------------------VLVRKEM-ASSP-----G-----SWFSSCLI-----T
LVALQMPA-------------------------------------------HL-------
--------S-GDVSKFHLAPLGGTAELLCPLSLWPVSVPM-QIRWLRPSRSQ-RSQ-AVH
VFRDGKDRDED----LIPEYKGRTTL-VRDI-QEGSV-TLQIRNVTLEDRGPYQCQ--IQ
-V-G--NLSRES-ILT------L--Q-VA-----VLGSDP-----------------YI-
------HMKGYDAG-WI-Q---L--VCRSVGWFPQPWAQWRDPEG-RRLLSLS-------
--------------------------ED-HSLDETGLFRTAVSSRIR-----D--NTLG-
NVSC-TIRNMV-LGR-EKTTA--------------------------------MLI----
------------------------------------------------------------
-----------------------------------------------------EAPSPGM
R---S-----S---------------------SA-VALAVV-LPV-----LGLLITVG--
I-----FLIWKQRRSREN--------------LLADHAKEKGNY----------------
---------------------------------IL-------------KVK---------
------------------------------------------------------------
------------------------------------------------------------
-------YKEQVTYSL-----------SLY-IITNSLLTLLEFMAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVKLGDR----K--QP-V------------PDN--
PQRFDFVVSVL-----------GFEY FT---AGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQSG-------QSHGNEYQALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGIISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNIAPLIIC-SEL-QKSEDSL
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNPS---LLPPQAPEL--PPV-------MSWPSDLGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LE---ILTGL-----KNCIVYCK--LC
MLVQDTFW-------------------------------------------PFTAR-FTV
--------V-GPG-HPVTAVVGEEIVLPCRLFPRMSAENM-EVRWFRSEF-T---S-FVH
LYRRGKDEFGQ----QMPEYHGRTEL-LKASLTDGNV-ALKIVNVRRSDEGQYRCS--VQ
-D-G--VFHVEA-ELE------L--K-IT-----GKFPAP-----------------GL-
------SAKGASDS-CSAR---L--RITSGGASPCFA-VFGDSFK-NYCPQ-M-------
------P-------------------HS-PIKDESGILFLFFFLMLR-----T--CIVK-
NASI-EYNSSL-LLQ-MKEC----H---LLFP-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------V
S---SPGA--V----------------P----WIV-VWIVT-LVI-----LLVFIGLT--
L-----FLLKSKHSHRRS-----------------------KCPGSTEAEFFPR------
---------------FQSG-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KLLRELEW-R-------------------RCLIDADNVT---L--D-EDTAH
VLLK----------LS-----EDGKCLQWGYD----V--QS-R------------PDI--
PERFDVDPCVL-----------GNERFT---SGRHS---WE-VD-V--GN----GHNWAV
GVAKESVS-R--K-GG--------------------------------------------
---------------ISMTPEGGIWAVQ-R--S--------GSNCWALTDY-V-----TP
---------------------------------LLLSQIPR---RVRVCLDCDRGQVVFT
NADTENL--IYVFPP---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGCV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASMIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LTS-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNQRSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---SIGEDS
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LLLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYQGRTSI-LRDGITEGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HI-
------EVKGYENG-GI-H---L--ECRYTGRYPQPQIQWSDAKG-ENIPAV--------
--------------------------EAPVVADRVGLYEVAASVIMR-----G--GSGE-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLAGA--
S-----YFLWRQQKEITAL---------SSEIESEQEMKEMGYAATE-------------
----------------QEIS---------LRESLQE-E---LSKD---MG-FWK------
------------------------------------------------------------
------------------------------------------------------------
----DLLSMAQ--------------------ALHAVALKSRKNADVI---L--D-PDMAN
AILL----------VS-----EDQRSVQRAEE----P--HD-L------------PDN--
PERFEWRYCVL-----------GCES FM---SG RHY---WE-VE-M------GDRKEWHI
GVCSKNVE-R--KKVW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRAHTEP-R-----TN
---------------------------------LKLPEPPR---KVGVFLDYETGDISFY
NATDGSH--IYTFLHASS-S-EPLYPVFRILTLEPT-------ALTVC-PIP-KVESS--
PD--P--D-----------------------LVPD--------HSLEIPVT------PGL
ANKSGEPQAEVTSL---LLPAQPGP-VRTIKL--------Q-AHNEALY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAPA------A----S-----LLASLLP-----
VLVLSLFV-------------------------------------------LVSAQ-FTV
--------V-GPA-EPILAMVGENATLHCRLSPERNAEDM-EVRWFRWRF-S---P-AVL
VYRGHQERAEE----QMAAYRGRTTF-VSADISKGRV-ALVIHNVTAYDHGVYSCY--FQ
-E-G--RSYDQA-LVR------L--M-VA-----SLGSEP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYY-EVVPALE-------
--------------------------EE-YTADRGGLFTVTMTVIVR-----D--CSVR-
NMTC-SVNNTL-LNQ-EVESV-------IFIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AMAVT-LPVLTLILF---TSG--S
I-----CLVKKHHRKKSI-LS---------------AEKDVEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ETARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVRR--GASR----QS-V------------PDN--
PERFDCRPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RIAIFLDCEAGDVSFY
NMRDRSH--IYTCPPVAF-A-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLILHRTRPVSQSHIKKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EWR---KIQYM-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------APDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHASF-S-EPLYPVFRILTLEPI-------ALTIC-PIP-KEVESSP
-D--P--D-----------------------LVPD--------HSLETPVT------PGL
ANESGEPQAEVTSQ---LLPAHPGA-EVSPSA--------T-TNQNHKLQARTEALY---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EVRWVQSRR-Y---P-AVY
TYVDGEHVTEE----QMAEYRGRTLL-VSDAIDEGRL-TLQIYNATTSDNGQYRCL--FE
-K-D--GVYQEA-SLD------L--K-IV-----GLGFSP-----------------LI-
------TVKEQKDG-EI-E---L--ICSSEGWFPEPHAQWKDMEG-KIIPS-F-------
------S-------------------EV-LTKGSHGLFHVETSLLVM-----N--SSIV-
NITC-SICNPL-LDE-EKKAT-------FSLS-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
M--------------------------------MS-FSWKI-VLV-----LVLPLVAT--
V-----VLVKWKRGK---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------KANVT---L--D-PNTAH
PGLF----------LS-----ERYKHVNHEHS----Y--SN-T------------SDG--
DST------AY-----------SKDQAR---RGS--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------LQL-------VG-SN------QLLAQHHTLYL
LVISLRFL------------------------------------------SC-KEE-VRV
--------V-GPG-EPILALVGEEVEFSCHLSPYLDAEDM-EIRWFRSQT-S---D-VVH
LYQGRQELYSQ----QMAQFQNRTRL-IKDDIMDGSV-NLQLHGIIPADEGLYGCR--FL
-S-S--NFSKEA-VWD------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKKG-GV-Q---L--KCSSSGWYPKPQAQWKDHKG-QCLSP-E-------
------M-------------------EA-IVQDARGLFNLETSVVVQ-----G--GAHS-
NVSC-SIQNSL-LFQ-KKEFT-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DA
F---LPGS--S----------------P----WKR-AFLGT-LVG-LPLLL---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------IK---FLLLL-L---LLLLLLLL--LL
LLLNTSPP-------------------------------------------DFTAQ-LTV
--------N-GPL-HPVTASLSEDIVLHCHLSPRTSAENM-EIKWFRSQN-S---S-YVH
LYHNGKEHLEK----QQPEYQGRTEL-LTDGIEDGKI-GLRILNVSFYDAGQYHCS--VK
-N-K--SFHQEA-TLD------I--K-VA-----ALGSTP-----------------LI-
------SIERYQER-GI-Y---L--VCRSRGWYPQPEVLWRNPSG-KHLSF-L-------
------A-------------------KE-TSQENNGLFEVQKDILLT-----E--GSNQ-
PLTC-VVRNRL-LNQ-EKGS----T---IHVA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------N
F---FPKI--D----------------P----WAV-GLCVSILVP-----VGLLIAI---
L-----YLINRNRLYNQLSLA--------TLEDMEIARDVFSW-----------SY----
-----SGTL-SNI-----STKEVT---NQFLHC---------------------------
------------------------------------------------------------
--------------------QI--------------------------------------
--------IWDQILGY-KAILPFSL-----------PSPFHHAANVT---L--D-PSTAN
KELI----------LS-----ADQKNVIQGFM----W--HN-L------------PDH--
PWRFDVERCIL-----------GKEGFS---SGRHY---WE-VE-V--GE----EGYWAV
GVARESVR-R--K-GR--------------------------------------------
---------------LSLDPDEGIWAVEKARVQ--------TVQYQALTIP-Q-----TP
---------------------------------LTLRKRPR---KVGIYLDYELGKVAFH
DVNHKMH--IFTFFAADFNG-ETIFPFLQVGIG--C-------WLTVC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------HMVVIAGEQAELTCQLSPPHSAELM-QIHWFMGDH-S---K-PVY
LYKGGREANEE----ADPEYVGRVEF-VKEAIGDGQV-TLRINNISISDEGSYQCS--FE
-D-N--GFSDMA-SMN------L--S-VA-----ATGLDT-----------------QI-
------RVHAPDTK-GL-L---V--ECKSEGWYPQPKMEWRDIRG-EEVPH-S-------
------S-------------------IS-SSQDGAKLFHMKMTLLLQ-----N--KSQN-
NITC-CIYNSL-TAH-EKKIN-------II------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TALHLS-----RPASLLL-----
LLLLSLCA-------------------------------------------LVSAQ-VTV
--------V-GPT-DPILAMVGENTTLRCCLSPEENAEDM-EVRWFQSQF-S---P-AVF
VYKGGRERKEE----QKEEYRGRTTF-VSKD-SRGSV-ALIIHNVTAEDNGIYQCY--FQ
-E-G--RSCNEA-ILH------L--V-VA-----GLDSEP-----------------VI-
------EMRDHEDG-GI-Q---L--ECISGGWYPKPLTVWRDPYG-EVVPALK-------
--------------------------EV-STPDADSLFMVTTAVIIR-----D--KSVR-
NVSC-SINDTL-LGQ-KKESV-------IFIP-ESFMP-------SRSPCVVILPV----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------MIILMIP-----------
-----------------I-AIW--------QKELEQERKETALKELE-------------
------------------------------------------------KEHVE-------
------------------------------------------------------------
-----------KEKEL--------------------------------------------
----QIKGKR-GQVWW--------------------LMA---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------ELVSGQ-WQV
--------T-GPG-KFVQALVGEDAVLSCSLFPETSAEAM-EVRFFRNQF-H---A-VVH
LYRDGEDWESK----QMPQYRGRTEF-VKDSIAGGHV-SLRLKNITPSDIGLYGCW--FS
SQ----IYDEEA-TWE------L--R-VA-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTAKWKGPQG-QDLSSDS-------
---------------------------R-ANADGHSLYDVEISIIVQ-----E--D-SG-
SILC-SIHLAE-WSH-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLLC---GALCAVVMGM--
-----IIVFFKSKGN----LQ---------------------------------------
-------------------------------------------WE---GRPL--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------V--PAQISSSVTHVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QE-V------------PHS--
EKRFT-RKSVV-----------ASQG FR---AG KHY---WE-VD-V------GQNVGWYV
GVCQDDVD-R--G-KNS-------------------------------------------
---------------VTLSPSNGYWVLRLT--T--------EHLYFTFKPH-L-----IS
---------------------------------LPPSTPPT---RVGVFLDYEGGTISFF
NTNDQSL--IYTLLTCQFEG-L-LRPYIQHAMYD-E---ERGTPIFIC-PVS-RG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIVEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-R---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TFVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWR---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIG-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASVDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------NFL----------AFLLLNFHVC
VLLLQ-------------------------------------------LLMPHSAQ-FAV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRT-----DGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIRWSNDKG-ENIPAV--------
--------------------------EAPVFVDGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTTS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRRA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---IRWR---SMQY--------
--------------------------T---------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LELPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLL---------GCL-----LI
FIALQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAMLGEDAELPCRLSPNVSAKGM-ELRWFREKV-S---P-AVF
VSREGREQEGE----EMAEYRGRVSL-VEDHIAEGSV-AVRIQDVKASDDGEYRCF--FR
-Q-DE--NYEEA-IVH------L--K-VA-----ALGSDP-----------------HI-
------NMKVQESG-EI-L---L--ECTSVGWHPEPQVQWRTHEG-EEFPS-M-------
------S-------------------ES-RTPDEEGLFTVRASVIIR-----D--TSMK-
NVSC-CIRNLL-LGQ-EKEVE-------ISIP-ASF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-LVV-----LGLLTIGS--
I-----FFTWRLYKERSRQRR--------NEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVM-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGVFLDYESGDIFFY
NMTDGSH--IYTFSKASF-S-GPLRPFFCLWSCG-------KKPLTIC-PIT-DGLEGVM
VVAD----A------------------------KD--------ISKEIPLS---PMGEDS
ASGDIET---LHSK---LIPLQPSQG--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPP-GPILAMVGEDADLPCHLVPTMSAETM-ELRWVSSSL-R---Q-VVS
VYADGKEVEDR----QSAEYRGRTSI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEAG-GI-R---L--ECRSTGWYPQPQIQWSNAKG-ENILAV--------
--------------------------EAPVVADGAGLYAVAASVTMR-----G--SSGE-
RVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
L---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLAGA--
S-----FFLWRQKKEKIAL---------SRETEREREMKERGYAATK-------------
----------------QEIS---------LRG-----I---QQWR---KIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------QWKMALFKPADVI---L--D-PDTAN
PILL----------VS-----EDQRTVQRAEE----P--RD-M------------PDN--
PERFEWRYCVL-----------GCGS FT---SG RHY---WE-VE-V------GDRKEWHI
GE-----------KRL--------------------------------------------
---------------VKMTPGDGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LTLPESPR---KVGVFLDYETGDVSFY
NAVDGSH--IFTFPHASF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KGGERSL
DP--D--L-----------------------VAPD--------HPVETPVA------LGL
ANESGEPQAEVTSL---LLPAQPGN-HETADT--------H-TEA---LY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------L-LS----------PS-ALGSHLPAP-------------------VPS----
LPVLSHVC---SVS---------------------------------------TDK-FLV
--------I-GPS-VPIVAELGGDAILPCSLFPPMNAEDM-ELRLFRTKF-S---E-EVF
VYRNRREQHEE----QMPQYAGRTSL-VTNLLTHGEA-AVHIQKVQASDNGTYTCF--FQ
-K-G--GRYAEA-ILE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGLEQD-GV-R---V--VCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SILNPI-LGQ-EKVMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQV--S----------------P----WKA-GFAVS-LTV-----LGLLLFGA--
G-----CFTRREHSAKLRERQ--------KRNNLDWI-KDAEKQEKEKG-LKAM------
------------DE-LQ----KEL------------------AWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------G-------------SVT---L--D-PGSAH
HCLA----------IS-----PERKSVTWKH-NA--E-----------------------
--YSLARCTVL-----------GLEGIT---SGRCY---WE-VE-IRSGE-GT---QWAV
GVCRGHVK-R--E-SW--------------------------------------------
---------------FTESPDTGFWVLR-K--F--------NNRYLIWTDP-Q-----QL
---------------------------------LCLRQDPR---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFPPASF-S-GTLFPYFLLK-GD-V-------TLSIC-STE-RGSEGLP
VP----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLP---------RCL-----FI
LTLLQLPK------------------------------------------LDA-AH-FDV
--------I-GPP-EPILAMLGEDAELPCHLSPNVSAEHM-ELRWFRRKV-S---P-AVL
VHRDGPEQEEE----QMPEYRGRVTL-AKDDISAGRA-ALRIQGVRASDDGEYQCL--FR
-E-NG--NYGLA-LLH------L--K-VA-----ALGSDP-----------------HI-
------HVEVRESG-EI-S---L--ECTSVGWYPEPQVQWRTPKG-EQFPS-T-------
------S-------------------ES-RNPDEKGLFTVASSVIIR-----D--TSME-
KLSC-YIQNLL-LGQ-EKEVE-------ISIP-ATS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPS-L-T----------------P----WIV-AMAVI-LMV-----LGLVTIGF--
I-----FFTWRLYKERSRERK--------NALSPK-------------------------
-------------------------------DKVLE-EL---KWK---RSPWH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDMT---L--D-PDTAH
PHLL----------LY-----EDLKSVRLEDS----R--RI-L------------PEK--
PERFDSWPCVL-----------GCAA FT---SG RHH---WE-VE-V------GDRTDWAI
GVCRENVR-R--K-GF--------------------------------------------
---------------DPIIPENGFWALELY-----------GNGYWALTPL-R-----TP
---------------------------------LLLSRPLH---RVGIFLDYESGNISFY
NMTDGSH--IYTFSKNIF-F-GPLRPLFCLWSSG-------EKPLTIC-PLA-DEPERVT
IIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASEVTDT---FHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYQGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HI-
------EVKGYEDG-GI-H---L--ECRYTGRYPQPQIQWSDAKG-ENIPAV--------
--------------------------EAPVVADRVGLYEVAASVIMR-----G--GSGE-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLAGA--
S-----YFLWRQQKEITAL---------SSEIESEQEMKEMGYAATE-------------
----------------QEIS---------LRESLQE-E---LSKD---MG-FWK------
------------------------------------------------------------
------------------------------------------------------------
----DLLSMAQ--------------------ALHAVALKSRKNADVI---L--D-PDMAN
AILL----------VS-----EDQRSVQRAEE----P--HD-L------------PDN--
PERFEWRYCVL-----------GCES FM---SG RHY---WE-VE-M------GDRKEWHI
GVCSKNVE-R--KKVW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKCRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGVFLDYETGDISFY
NATDGSH--IYTFLHASS-S-EPLYPVFRILTLEPT-------ALTVC-PIP-KVESS--
PD--P--D-----------------------LVPD--------HSLEIPVT------PGL
ANESGEPQAEVTSL---LLPAQPGP-VRTIKL--------Q-ARTEALY-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--LL
SLVLSLL-------------------------------------------KLGSGQ-WQL
--------F-GPN-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAGGRL-SLRLENITVLDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWFPRPMAKWKGPQG-QDLSADS-------
---------------------------R-TNMNMHGLFDVELSLTVQ-----E--N-AG-
SVSC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WYL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQGK----RE--------R------------------------------
--------------------------------------------------EA--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------WAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHREA----P--QD-M------------PPS--
EKRFI-RKSVV-----------A SQNFQ---AG RHY---WE-VD-V------GHNQRWYV
GVCRDGVS-R--R-KKR-------------------------------------------
---------------VTLSPNHGYWVLGMN--A--------ENLYFTLNPH-F-----IS
---------------------------------LCPRTPLT---QIGVFLDYECGTVSFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSHN-E---QNGTPIVIC-PVT-QESERKV
SWQS---------------------------------------------------ASAIP
EASNSEFSSQATTP---FLPGSDV------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MIF---PIRVCSLHPP---V
SLQPLTAT---SVS---------------------------------------TEE-FRV
--------F-GPS-DPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRF-S---E-AVL
VYRDQEEQKRE----QMPEYSWRTSL-VKDQFHQGKA-AVRIQNVQASDSGMYICH--FK
-Q-G--VFYDEA-ILE------L--K-VA-----AMDSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSRR-KNLTA-S-------
------S-------------------EI-HREDAQGLFSTETSLVVR-----D--SSVR-
NVTC-STFNTV-LGQ-EKAMT-------MFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--S----------------P----WKP-AFLVT-LTM-----LGLLVFGI--
S-----YLLRRERSARLIMQE--------MSGNLQSV-KEKK--TKEYT-L---------
------------RT--AGELWKELA-----RRKAAY--M--AD-----------------
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQTW-------------TFT---L--D-PASAH
HNLA----------IS-----QDRLSVTRRFSGM--H-----------------------
---LYDFSSVL-----------GSSGIS---SGRHY---WE-NL-SIIFS-AS---EN--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----RPASLLLL--L-
LLLFSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRQRTEE----QMEEYRGKTTF-VSKDIRRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSSDEA-ILH------L--V-VA-----GLGSKP-----------------HV-
------EMRGHEDG-GI-R---L--ECTSGGWYPKPLTVWRDPYGGGVVPALK-------
--------------------------EV-SMPDTDGLFMVTTAVIIR-----D--KSVR-
NMSC-SINNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPWAVALAI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILMIL-----IAI--C
I-----YWINKLQKEKKI-LSG--------EKEFEQETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KQE----EL----------------------------------------
-QV---KEKLQEELRW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--CPFR-HLGES-M------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KGQYRAMSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
DMKDRSH--IYTCPRSAF-S-MPVRPFFRLGCEDNP-------I-FIC-PAL-AGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA--FS---SLS--------GYF------VA
ILLLQ-IT------------------------------------------VLTSEQ-FTV
--------S-SSR-NHHVVMVGSQAELSCRLSPPQNAQLM-QVGWFRDPH-S---Q-MIY
LYEDGEEHPGE----GVQNYTNRTVF-LKDALEEGKI-TLQIYNVTAFDGGQYRCF--FK
-D-G--HTYEEG-IVD------L--R-VA-----AVGLDV-----------------QI-
------NVQVLNTE-GF-V---V--ECTSGGWFPQAQMAWKDSSG-NVIPH-S-------
------S-------------------KS-YSQDGAGLLHLKMTILLK-----N--NTHG-
PVTC-CFYNPV-TGQ-EKRAG-------IVIP-DILFK---------SEYMSLMSHK---
-------ISY-PWIYLSIVVALLF---------------------------------LRI
-KVAQNIRCVHLVFQCLPFL---MY-IGILPIYLQF---------------RKRVSVSDD
L---FLLY--S--------------------IWT-DDLCI-ILGI-LML-FFTLLTFV--
L-----LYTLKDFVQLRT------------SGFSSET--------EE-------------
------------------------------------------------------------
------------A-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MASFPGLF-----PA------G--VL-P-----
AL-LWVSM---WGS--------------------------------------PVSG-FSV
--------M-GPA-QPIKVSLGADATLPCQLSPEQSAAHM-QIRWYRTQL-S---P-VVL
MYQNGQEQDGE----QMLEYRGRTEL-VEDSISRGAV-ALLIQHVRASDDGQYWCH--FN
-D-G--HISREA-VVE------L--Y-VI-----GLGSAP-----------------HV-
------RMMGPEDH-GI-Q---V--LCSSGGWFPKPWVQWRDTAG-EKLLS-L-------
------S-------------------ES-QTQDGDGLFHVEASLVVT-----D--SSLG-
NVTC-SVQNPV-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKT-ALAGT-LPV-----LVLLLIGI--
S-----YTGWREHRAKTREVE--------KRKEASHQ-RDKVAKEKEEA-HSIK------
------------SK-----SGSKSNQRFLEKLQMLC--VQ--DWK---KALIYP------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VPVI---E--N-HENIH
QNNS----------DF-----RK--------------E-PQ-A------------VLCKK
--QGGGNLLKL-----------DQKGFT---KGRHY---WE-VD-IEDTD------EWTL
GIFEEPTE-R--S-GL--------------------------------------------
---------------LSDLEKMKFNVLE-K--R--------GCEYRALTCSRQDIFQKEP
---------------------------------LQIEKCPL---KIVIFLDYEDSDISFY
DMTDETH--IFSFTHANF-S-GSVYPYFKLKSME-F-------SPAAR-Y----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MSLVLTEPA------ASLHFS-----LPASLL-L----
-PLLSLLA-------------------------------------------LVSAQ-FTV
--------Q-GPA-DPILAMVGENTTLHCHLSPENNAEDM-EVRWFRSQF-S---P-AVL
VYKGGRERAEE----QMEEYRGRTTL-VSKDISRGRV-ALLIHNVTAQENGIYRCY--FQ
-E-G--RYYDEA-IIH------L--K-VA-----GLGSKP-----------------LV-
------EMKGHEDG-GI-R---L--ECTSGGWYPKPLAVWRDPYD-QVVPALE-------
--------------------------EA-YTADADGLFMVTTAVIIR-----D--SSLR-
NMSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------SVSPWVVILAL----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAILIIL-----MAV--S
I-----CYIKKLHREKKI-LSG--------EKKALC------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------LSLAGW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSQ----QR-V------------SDN--
PERFDCQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMAWTV
GVCRDSIE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------ENKYRALCSPER------I
---------------------------------LPLRERLG---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSPF-A-GPLRPFFRLGSDDSP-------L-FIC-PAL-AGANGIT
VPE--------EGLILHRINQSKEFQKLQFKIPW--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
TLNLVEEYV-----------VAT--------------------------------MCVMP
HSRK-------------------TPVHMERPPSPS-----A-----SQLLSCLL-----A
LAFLQLPA-------------------------------------------QV-------
--------S-GNTDKFYLAPLGGRAELPCPILLWPGMVLS-EVRWERPTHLPRT-Q-AVH
VFRDGQDSDED----LMPEYKGRTTL-VRDT-HKQSY-ILYISNVRLEDRGPYQCQ--FR
-I-G--NQSQEG-NVT------L--Q-VA-----VSGSDP-----------------FI-
------HVKSYDAG-WI-Q---L--VCWSMGWFPKPWTEWRDAQG-RVLLSLS-------
--------------------------ET-HSLDETGLFRTAVSSRVR-----D--STLG-
NVSC-TVRNEI-LGQ-EKTTA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPAPGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLIILLG--
I-----WLICKQKRSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KSL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVVVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDK----K--RS-V------------PDH--
PQRFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSDSVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RRNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---KNTAPLVIC-TEL-QKSDESV
VTKQ---------------------------------------------------EGKS-
-RANGDVTLKVNPS---LLSPQGSEL--FPVN---DT---WPSSLGPALQGFKAPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------RSAP-D------LKGLTCL--LS
ISCHHIPQ-------------------------------------------IPPRA-FQV
--------Q-GPH-EPLVAILGGEAELPCFFLPPQNVKNM-EISWTRSLP-S---H-VVH
LYEDGRDKPEE----AMEEYLGRTEL-VKNVMPKGIV-VLRILNVQPSDNGQYRCA--FK
-N-G--SFYSDA-VIE------L--K-VA-----ALGSHP-----------------QF-
------HVEVTKSR-QL-R---L--ECKSEGWFPQPKVQWRDSEE-TEIPA-E-------
------F-------------------ET-HTQDKGGLFHVTTALLLR-----E--ASQK-
NLTC-SIWNPV-LNQ-KKEEQ-------LFTT-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
S---FSMC--N----------------P----STV-ASLIV-LFT----------IAC--
T-----VFSWTTY-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------FS---PCSAV-----CSALPGYL--VL
CLALQAPR-------------------------------------------LEAAD-FKV
--------F-GPD-QPVIAIVGEDIVLPCHLSPRMSAENM-EVTWFRSQR-S---L-FVH
RYCDGKDQYGK----QMPDYQGRTEL-LKDGLPNGSI-ALRIFNIRPFDEGQYSCF--VQ
-D-T--IVYEEA-LLE------L--K-VA-----ASGSAP-----------------HI-
------SIEH-DEG-GI-R---L--VCRSSGWYPEPAVLWIDPRG-QHVLS-L-------
------S-------------------ET-NFQKVNELFEIENSIIIT-----E--NSHQ-
NLSC-VVRNIY-TKH-KEKST---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
F---FPRM--N----------------P----WMV-ALWVI-LVT-----LFGFIGLT--
I-----YLFKIKARKHLLVGE--------FIL--SFK----KCDIKREA-----------
---------------LVQPMVELE---ETLRDK---------------------------
------------------------------------------------------------
---------------------S--------------------------------------
--------TLSQSLQW-R------------------RESFLAPATVT---L--D-PDTAH
PDLA----------LS-----EDGKRVRRGDI----R--KD-Q------------DTN--
SERFEYERCTL-----------GCESFT---SGRHY---WE-VE-L--GG----GDYWAV
GAASDSVK-R--K-GE--------------------------------------------
---------------IIFKPEEGIWAVG-H--W--------GNKYLAATYP-R-----SQ
---------------------------------LNLRWVPR---RIRIFLDYDLGQVAFF
DADKGAL--IFAFPTASFSE-EGIRPFFWVWDME-S-------QLRLC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SPDFLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PN-SE--VKV
--------V-GPE-YPILALVGEEVELPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSVVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---SPGA--S----------------P----WKG-AFVGA-LAA----LLAVLAGLA--
L-----GVLQQRRRCQEKLKK--------EAEK-REG---KLTAELE-------------
------------------KLQKEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------LND--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDCEAGKLSFF
NVSDGSH--IFTFHDTF--S-DALCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTCVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIRWSNDKG-ENIPAV--------
--------------------------EAPVFVDGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTTS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRRA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRE--------------------
-----------------------------------------------------L------
----------------------YKNTD---------------------------------
------------------------------------------------------------
----LFLICVS--------------------FLSEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RYY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LELPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KEEESVS
LE--T--PV-----------------------------------------T------LGL
ARESGEPQAEVTCL---CFSLPSLELRASPST--------A-TNHNHKATGTH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MLMEVP------ASLQFN-----QATSLLL-----
-PLLSLLV-------------------------------------------LVSAQ-FTV
--------V-GPA-GPILAMVGENITLPCYLSPEKNAEDM-EVRWFRSQF-S---S-AVL
VYKGRRERREE----QMEEYQGRTTF-VSKDIGQGKV-AVVIHNVTAHENGKYCCY--FQ
-E-G--RSYDEA-IIL------V--R-VA-----GLGSKP-----------------LI-
------EMKGYEDE-GL-W---L--ECTSAGWYPEPHAVWRNPYG-KVTPSLE-------
--------------------------EA-YTVDGDGLFTVTMIVIIR-----D--SSVR-
NMTC-SISNAL-LGQ-ELETV-------IFIP-ESFTP-------SLSPWTVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------S-LAILILL-----MSG--I
I-----SLIKKLHRRKKN-VSE--------EKDSECEERE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------RRTLVHAADVV---L--D-PDTAH
PELF----------LS-----EDGRSVCR--GPSR----QS-L------------PDN--
PERFDCRPCVL-----------GQES FS---SG RHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPMKEHLC---RVAVFLDYEAGDVSFY
NMRDRSH--IYTCPLSTF-S-GPLRPFFRLGSDDSP-------L-FIC-PVF-TGAKGVV
VPE--------GGLILHRPRTCHPMQGQFSSLRAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TAQ-FTV
--------T-GPD-HPITAAVGGDAILACHLSPRTSAQAM-EVRWYRSQF-S---P-VVH
LYRDGQDQYEK----QMQEYQGRTEL-LRDDIANGSV-SLRICDIRPSDEGYYTCF--FE
-S-L--TFFQEA-SIL------L--Q-VA-----ALGSGP-----------------DI-
------SVEGHQDG-GL-W---L--VCRSSGWYPRPEAQWRDQQG-KLLPS-A-------
------F-------------------EK-ISPEAGGLFQTKIAMVLK-----E--ESNQ-
KVSC-HVRNPR-DNR-ERESA-------ISIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------H
F---FQWG--S----------------P----WVV-TLGVI-LAL--------FIVLA--
S-----YGFWRQHRAKDRQTN--------S-KIYSKY-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KLQTELRW-R-------------------CAQLYAVDVT---L--D-PDTAH
PRLV----------LS-----EDRKHVSYGDM----R--QD-L------------PDI--
PERFDPVPIVL-----------GVDRFT---DGRYY---WE-VE-V------GDKTRWTL
GVCKESVS-R--K-EW--------------------------------------------
---------------LTPSPENGHWTVW-L--R--------HGEYEACTCP-L-----KH
---------------------------------LTVSTRPS---RVGVFLDYEAGKVSFY
NVTDRSH--LFTFTG-TF-S-ETLRPCFYPGVTAEG---TNAAPLTIC-PV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT---G---VL----------LC------VV
LHFLQ-MV------------------------------------------TQSSEK-FTV
--------T-GLQ-RPVLAPLGGNVELSCQLSPPQQAQHM-EIRWFRNRY-R---E-PVY
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLRIFKLTADDDGSYHCV--FK
-V-G--EFYEEH-ITE------I--K-VT-----ATSSVM-----------------YI-
------LMQPPNIK-GV-M---L--ECHSGGWFPQPHMEWRDNKG-NIIPA-T-------
------S-------------------KA-HSQDENKLFNMTMTLLIE-----A--SSHR-
SITC-YLQNLL-THQ-EESIS-------IVLS-GELFS-------WKRVWIMILTTIGFM
MIA-FCMTYCVQQ-HLLYGTF---------------------------------------
---SKGKCHWLKSTMIFMFS---VIAVTGVMLILHLK---------------QRVPVSDQ
H---FELD--T--------------------LWL-EDISV-ILCV-LIV-FIIKLI-S--
F-----IYFRLEGDH--------------QGWSLPPY--------LSATPT---------
------------------------------A-----------------AICR--------
---LAV-------PEYS-----RGHLQL------------DS-----EDDLAGMGPSPFF
ITPCF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WLV
--------F-GPG-KPVQALVGEDAAFSCFLSPKTNAEAM-EVQFFRGQF-P---S-VVH
LYRDRKDQPFM----QMPQYQGRTKL-VKDSIAEGRI-SLRLENITVLDAGLYGCR--IS
SQ----SYYHEA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SIAGYVDG-GI-Q---L--LCRSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNTDMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSR-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------T----------------S----LHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QD-M------------PHS--
EKRFT-RKSVV-----------ASQ SFQ---AG KHY---WE-VD-G------GHNERWRV
GVCRDDVD-R--R-KQH-------------------------------------------
---------------VPLSPDHGYWVLRLN--G--------GHLYFTLNPR-F-----IS
---------------------------------LIPRTPPT---QIGVFLDYECGTISFF
NINDQSL--IY-TLTCQFEG-L-LRPYIEYPSHN-G---QDGTPVVIC-PVT-QESEREA
SWQK---------------------------------------------------ASTIP
ETSNSESSSQATMP---FLPRGDV------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA--FS---SLS--------GYF------VA
ILLLQ-IT------------------------------------------VLTSEQ-FTV
--------S-SSR-SHHVVMVGSQAELSCQLSPPQNAQLM-QVGWFRDRH-S---Q-MIY
LYEDGEEHSGE----GIQNYMNRTVF-LKDALEGGKI-TLQIYNVTVFDGGQYHCF--FK
-D-G--HTYEEG-IVD------L--R-VA-----AVGLDV-----------------QI-
------NVQVLGTE-GF-V---V--ECTSGGWFPQAQMAWRDSSG-NVIPH-S-------
------S-------------------KS-YSQDGAGLLHLKMTILLK-----N--STHG-
PVTC-CFYNPV-TGQ-EKRAG-------IVIS-DILFK---------SEYMSLMSHK---
-------ISY-PWIYLSIVVALLF---------------------------------LRI
-KVAENIRCVHLVFQCLPFL---MY-IGILPIYLQF---------------RKRVSVSDD
L---FLLY--S--------------------IWT-DDLCI-ILGI-LML-FFTLLIFV--
L-----LYTLKDFVQLWT------------SGFSSET--------EE-------------
------------------------------------------------------------
------------A-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GP---CFY--------GHC------IV
MFLLH-MI------------------------------------------TPSSEK-FMV
--------T-GLE-GPVVAPLGGNLELSCQLFPSQDAQHM-EIRWFRHHY-T---Q-PVH
LYRDGKDIYGE----TILKYVERTEL-LKDAIGEGRV-TLRIFNVTVDDDGPYHCV--FK
-D-S--NFYEEH-ITE------V--K-VT-----G-FYEF-----------------TF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--GL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTV
--------N-SLE-KPVLAALGGNVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNISADDDGQYHCF--FK
-D-G--DVFEEA-IAE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDGNKLFNMKMSLLLS-----D--SSHG-
NITC-YLRNPV-TGQ-EERTS-------IVLS-DKLFP-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---MCVIIGLTITLHHR---------------NRVPVSDR
K---FQLV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGNC--------------KRKGGNSE--------GIIPLMDLQ-M----
-------------SGR--------------V-----------------TILI--------
--LVP-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------QQVS-T------IYHGSRI--SL
YLCLQMLI-------------------------------------------MGAGA-FQV
--------Q-GPH-EPLVAILGGEAELPCFLLPPQNVKNM-EISWTRYLP-S---D-VVH
LYEDGRDKPEE----AMKEYFKRTEL-KRNVTHKGIV-VLRIFNIQLSDSGQYRCA--FQ
-H-G--SFYSDT-VIE------L--K-VA-----ALGSHP-----------------QL-
------LVEVTKSR-EL-R---L--KCKSEGWFPQPKVQWTDSEG-REIPA-E-------
------S-------------------EA-HTQDKGGLFHVTTSLLLR-----E--ASQK-
NLVC-SVWNPV-LNQ-KKEEQ-------LCIA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
F---SLSS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-HSQ-VVH
MFRDGKDQDED----VMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VIASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPLKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPL-GPILAMVGEDSDLPCHLFLTVSAETM-ELRWISSSL-R---R-VMN
MYADCKEVEDR----QSAEYRGRTSI-LQDGISAGNA-ALRIYNVTASDNGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-IPIYPSTALDSDI-----------------HI-
------EAKGYEDG-GI-H---L--GCRSTGQYPQPPIQWSNTKG-ENIPAV--------
--------------------------EALVVADGV-----AASVIMR-----G--SSGE-
DVSC-IIRNFL-LGL-EKTAS-------ISIE-V--------------------------
------------------------------------------------------------
------------------------------------------------------LPFTNP
F---FRSA--K----------------P----WIA-ALAGT-LPI-----LLLLLAGA--
S-----YFLRQERKEKIAL---------SRKTQRKRV-------VKG-------------
----------------EWSV---------EKNKNT--------------DLFLI------
----------------------C-------------------------------------
------------------------------------------------------------
---------VS--------------------LLSEWKTALFKPAYVI---L--D-PDMAN
AIVL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PERFEWRYCVF---------------------GRHY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KNVW--------------------------------------------
---------------VKMTPENGYWTMGLT--G--------ENKYQAV------------
---------------------------------------TE---KVGIFLDYETGEVSFY
NATDGSH--VYAFLHASF-S-EPLYSVFRILTLEPT-------ALTIC-PTP-KQVESSP
D---P--DL----------------------V-PD--------HSLETPVT------PGL
ANESGEHQAEATSL---LLLAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVPT
------------------------------N------SCPL---------VCL-----LT
FTVLQLPT------------------------------------------LDSAAP-FNV
--------T-APQ-ESVLAVVGSDAELTCRFSPNASSEQM-ELLWFRQTR-S---P-AVL
LYRAGQEQEGE----QMTEYHGRATL-VTARLLDGLA-TLRIRGVRVSDQGQYRCF--LK
-D-ND--DSEEA-AVH------L--K-VA-----AVGSDP-----------------YI-
------SMKVQENG-DM-E---L--ECTSSGWYPEPQVQWRTANR-EMLPP-T-------
------S-------------------ES-RNPDTEGLFTVTASMM IR-----D--NSIK-
NMSC-CIQNIL-LGQ-GKEVE-------ISLP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-ALAIV-ILA-----LGFLAIGS--
I-----FFTWKLYKERSRERK--------KEFGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYELGDISFY
NMSDGSL--IYAFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-PTA-NVPEKIT
VIAN----V------------------------QD-----------NIPLS---PLGEGS
TSGDKDS---LHSK---LIPFSPSQA--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------LG-HWAKVSNRAR-----D--STLG-
SVYY-TICGMA-LGQ-EETSH-------AALS-G---------------WSQVVSV----
------------------------------------------------------------
-----------------------------------------------------SAESPDS
F---P-----P---------------------SA-VALTVI-LPV-----LGIFIVVG--
L-----YIIWKQRRSKESHFLL--LFLPLE-NLLSDHAKEK-GN----------------
---------------------------------SMY------------RIR---------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VTVT---L--D-PDTAH
PKLI----------LS-----EDRKCVKLGDT----R--QP-V------------PDN--
PERFDFVVSVL-----------GSEY FI---AGC HY---WE-VS-V------ADKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------QGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
DVTNQSH--IFTFTHSF--S-GPLRPFFEPCLRDGG---KNTAPLIIC-SEL-QKPEEST
DPNT---------------------------------------------------EEKG-
-QANGEVPLQVDPF---LLPAQTSEL--VPLK---DMILSWSSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MCEGQ-PELQ---CR-----SPP-SSAALLTAALRGYNT-----
---VTSPLAQGSE-----NTFWSWCPL----------------------------MVNEM
---P----E--------------DRRVMEPA--FS---SLS--------GYF------VA
ILLLQ-IT------------------------------------------VLTSEQ-FTV
--------S-SSR-SHHVVMVGSQAELSCQLSPPQNAQLM-QVGWFRDRH-S---Q-MIY
LYEDGEEHSGE----GIQNYMNRTVF-LKDALEEGKI-TLQIYNVTVFHGGQYHCF--FK
-D-G--HTYEEG-IVD------L--R-VA-----AVGLDV-----------------QI-
------NVQILGTE-GF-V---V--ECTSGGWFPQAQMAWRDSSG-NVIPH-S-------
------S-------------------KS-YSQDGAGLLHLKMTILLK-----N--STHG-
PVTC-CFYNPV-TGR-EKRAG-------IVIS-DILFK---------SEYMSLMSHK---
-------ISY-PWIYLSIVVALLF---------------------------------LRI
-KVAENIRCVHLVFQCLPFL---MY-IGILPIYLQF---------------RKRVSVSDD
L---FLLY--S--------------------IWT-DDLCI-ILGI-LML-FFTLLIFV--
L-----LYTLKDFVQLWT------------SGFSSET--------EE-------------
------------------------------------------------------------
------------A-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQR-------------QF
----SKASR-----------PCLPWVLMEPA------AALHFS-----LPASLILL----
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALIIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-FPPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SISDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EKESERKTREIAVKELK-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLG-HLGES-V------------PDN--
PERFNSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-EE--------------------------------------------
---------------VLLRPRNGFWTLEMC-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRLAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGASGIT
VPE--------EGLILHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDTA------AAPHFS-----LPGSLLL-----
-LLLSLCA-------------------------------------------LVSAQ-LTV
--------V-GPA-SPILAVVGENTTLHCHLSPEKNAEDM-E-------F-S---A-AVF
VYKGGRERTEE----QMEEYRGRITF-VNKGTSRGSV-ALVVHNVTAQENDIYRCH--FQ
-E-G--WSYDKA-ILR------L--V-VA-----GLGSKH-----------------LI-
------EIKAQEDG-SI-W---L--QCISGGWYPEPLTAWRDLYS-EIVPTLK-------
--------------------------EV-SIADADGLFVVTTAVIIR-----D--KSVR-
NVFC-SIKNTL-LGQ-EKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--T----------------P----WMV-SLAVI-LAVFLIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEEE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------R-TFLHAA--P---K--N-PNTTH
PELF----------LS-----EDQRSVRQ-------------V------------PDN--
PERLDSQPCVL-----------GWES FA---SG KHD---WE-VE-V------ENVMLWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEVF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---WVAIFLDFEARDVSFY
NMRDRSH--IYTCPHSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PVL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKPE--FS---YFS--------GLC------VY
FLFLQ--V------------------------------------------TISSEK-WMV
--------T-TPT-RHVLARVGGQAELSCQVIPPQSVGYM-EVRWFRSGH-S---Q-PVY
LYRGGHSMSGE----AAPEYANRTQF-VKEAIGEGKV-TLRIHNISILDDGPYRCS--FN
-D-S--GFIDVA-SMN------L--N-VT-----AVGLET-----------------EI-
------HVQAPDAD-GV-I---V--ECNSGGWFPKPQMEWRDSNG-ETLRH-S-------
------M-------------------KS-YSQDEARFFHMKMAL-LT-----N--RLQG-
NIIC-CIFNPV-TGE-EKQTN-------IILA-NELFY-------EDHIWMKILVIIACI
ILFIISFLLLISCFCRRQGCAS-----------------------------------GYV
SKCFCVFNSWPVQILN--FL---FCTGLLFGIYLPHR---------------SRVSLSDP
Q---FPLY--N--------------------KWI-KDLLF-VILF-LTV-FFVLPIIA--
L-----ILRRLSPTCLNK--Q---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LIFLRLSV-------------------------------------------HV-SG-R--
--------T-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-AVH
VFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIKVC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLQFVAVT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEYFT---TGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------EVE--VL
CLGLSVF-------------------------------------------FPPTGQ-WQV
--------I-GPD-KHVKASVGEDAIFSCFISPETSAEAM-EVRFFRNEF-S---A-VVH
LYSDGKDHYDM----QMPTYRGRTEL-LKDYIVDGRV-SLRMEDITPSDAGLYGCS--FS
SQ----TYYQEA-TWE------L--Q-VS-----ALGSTP-----------------LV-
------SVMGYVDG-EI-Q---L--CCQSSGWFPQPTVKWKGPQG-HDLSSDS-------
---------------------------K-VNANKQGLFDVKTYLLVQ-----E--K-TR-
NLSC-SIQNVD-QNL-KVESK-------IWIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRS-PTILLGLLC---FGLCVCIIGL--
-----MIFFFKYRRK----LQ--------ADL----------------------------
------------------------------------------NWR---KQQA--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QDEWRDARKHPVELT---L--D-PGTAE
SHLH----------IS-----D-LRTVTYLDV----P--QY-V------------TNL--
WMRFS-NMAVV-----------ASQGFS---EGKHY---WE-VD-V------GQNVGWCL
GVCLDNVE-R--A-MQN-------------------------------------------
---------------VTLSPINGYWVFGKN--T--------QQQYFSLNPD-T-----IN
---------------------------------LFPRIPPT---HVGIFLDYEGGTISFF
NINDQSL--IY-TLTHQFAG-L-LRPFIHYSPGL-E---GNQTSIVIC-PVS-CGSGKEG
HL----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FQV
--------I-GPN-EPIQALVGEDVIFSCHILPKMSLVDM-EVRFFKNQF-Y---T-LLL
LYKDGK---KR----QMQEYRGRTQF-VQDAITEGTV-SLKLRNITPSDKATYGCW--FG
-S-Q--TFYQHY-IWE------L--Q-VA-----ALGSTP-----------------VI-
------SLEEYRDG-GI-L---L--VCKSAGWLPQPSVQWRQDPG-Q-YLS-S-------
------N-------------------YT-IVQDDHGLFFIETTLTIK-----E--HSNK-
NILC-SVLNIA-LKQ-EKES----R---VQVA-XXXXXXXXXXXX---------------
------------------------------------------------------------
-------------------------------------------XXXX-----X-XXXXXX
X-------------------------------------------------------XX--
------------X-----------------------X--X-X-X---X------------
------------------------------------------------------------
---------------X------X-----------X-X-----------------------
------------------------------------------------------------
----XXXXXXXXXXXX-XX------XXXXXXX-----XXXXXXXEVT---L--D-PETAN
PKLC----------VS-----EDHKKVTYEDT----H--AL-N------------VSE--
TEKRFQSPSVV-----------ASQDFY---LGEFY---WE-VE-V------GEKNRWYL
GVCWDEVD-R--K-SKD-------------------------------------------
---------------PELSPANGYWVLG-R--W--------NQKE--HFTP-L-----VD
---------------------------------KVLFKQPK---RVGIFLSCEYEQVSFY
NVTDKSH--IYTF-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MANT-QGRD-IFPPSC-S---II---FLL--LQ
LLSCSLSA-------------------------------------------NGKAD-FSV
--------S-GPG-QPVLAMVGESVKLRCHLSLNISVKDM-EVRWYREEL-S---P-AVH
LRKKGKDVPEE----QMWQYEGRTTF-LMSGLAQDQA-VLTIHNVTVFDNGTFHCK--FK
-D-G--MASAET-TLW------L--R-VA-----GLGSEP-----------------RI-
------QVRAGQDE-GI-R---A--ECTSEGWYPEPQVEWRDFRG-QTLPS-T-------
------T-------------------NL-TVSPTTGLFAVVSNVTVW-----D--RDVG-
NLSC-SLSNPL-LQE-RMEA----K---ICLP-DPLLA----------------------
------------------------------------------------------------
-----------------------------------------------------------Q
L---SRSF--P----------------S--MAWRT-VLPVI-LIV-----VGLVATGA--
T-----CLFWKRQRDRDRVQL--------EEEKLY-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------REEEQLSQGW-P-------------------ED-VIYVSPS---L--D-PDTAS
PKLA----------LS-----EDRKTVRRLFF----E--QE-L------------PNA--
PSRFDRDPCVL-----------GLEQ FS---AG RYY---WE-VQ-V------GHRKAWNL
GVCLESLD-R--K-GR--------------------------------------------
---------------IPKSPQHGLWALE-L--Y--------KEGFWALAFP-R-----VR
---------------------------------LHLSEPLH---RVGVFLDCDAGRISFY
SVSNGSL--IYAFSGLSF-S-APLRPFFCLWTHDPS-------PLTIC-SER-QPPEA--
--LG----P------------------------PQ--------GEGQDRVGTL---LQQD
P-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SPDFLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PN-SE--VKV
--------V-GPE-YPILALVGEEVELPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSVVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---SPGA--S----------------P----WKG-AFVGA-LAA----LLAVLAGLA--
L-----GVLQQRRRCQEKLKK--------EAEK-REG---KLTA----------------
----------------------EL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------LND--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDCEAGKLSFF
NVSDGSH--IFTFHDTF--S-DALCAYFRPRAHDGS---EHPDPLTIC-PLR-VRGTCVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MQ----------EV-A-AFHRTRP------------------SSLF----
IYLKCSVY---SLS---------------------------------------TDD-FLV
--------M-GPS-DPIVAMLDGEATLPCSLVPAMNAEHM-ELRWFRTKF-S---E-AVL
IYQNGREQHEE----QMPQYAGRTSL-VRDLLTQGQA-AVRIQNVRASDNGRYSCF--FQ
-K-G--GHYEEA-TLE------L--K-VA-----GLGSAP-----------------QV-
------HIEGPEQD-GV-R---V--VCKASSWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGN-LTV-----LGLLLFGA--
G-----FFTRREHSAKVQERQ--------KQQELHQA-KEEDLRAEEEA-LKAR------
------------DE-LQ----AEL------------------AWR---KVQLYA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------G-------------SVT---L--D-PGSAH
KNLA----------LS-----PGKTSVTWKD-TC--V-----------------------
--VSDGRCSVL-----------GLEGIT---WGRYY---WE-VD-IRNGV-DS---EFAL
SVCREHVK-R--T-GF--------------------------------------------
---------------YTESPDKGFWVVG-C--F--------NNGYNACTTSNP-----TS
---------------------------------LSLRQHPS---RVGIFLDYDGRDVSFY
NMTDGSH--IFSFPRASF-V-GKLFPYFMLKSGN-V-------SLSIC-LVA-RESEGLP
VPPN----N------------------------SS----------FEEPVRHHQ-EV---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGPA------TSLSVS-----PQGALVF-----
LLFLSAFG-------------------------------------------QLSAQ-FTV
--------V-GPP-EPVLAMVGESSTLRCHLSPEKSAEAM-EVRWFCTHF-S---P-AVL
VYRGGRERPEE----QMQQYRGRTSL-EGAGLGRGRV-ALVIHNVTAHEKGDYSCS--FQ
-E-G--MSYEEA-IMR------L--E-VA-----GLGSKP-----------------LV-
------EMKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG--VVPALE-------
--------------------------EL-TLLALTASSPVALAVIIR-----D--DSVQ-
DVTV-ACPGVVAVGM-WQRCS-------ALIP-AAPSL-------SESGH--ALRA----
------------------------------------------------------------
------------------------------------------------------------
----VLTH--G----------------S----GIV-ALVVI-LPTLTLL-----MAG--G
G-----CLMKKLQKEKE----------------VEREEKEIAWRKLW-------------
------------------------------------------------EERLT-------
------------------------------------------------------------
-----------EG-----------------------------------------------
---------------W--------------------RRTLLYAAVDASIGA--N-PSMIH
PHS------------------NNQRSAISVSVVIA----LW-L------------RDE--
SERRQHWPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVRAWAV
GVCSADLP-R--K-GE--------------------------------------------
---------------EA--AGGGVWALELF-----------GGQYRPLAAPAL------L
---------------------------------LPLRERLG---RVGVFLDYEAGDVSFY
HMRDRSH--IYTCPRSAF-A-GPLRPFFLLMSDDSP-------L-AVC-PAF-VGA-GVT
LPE--------DGLVLHGAGARRGR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------M-ANCS-----I-----FSLSSCLI-----I
LISLQLPT-------------------------------------------KGS------
----------GKVGKRNLVMLGTKAELPCPLSVWMAPESV-EVKWLRTPESH-ISQ-AVH
VYRNGQDLYGE----QMPQYKGRTAL-VKDS-QEDSF-TLEIYNVRLEDQGEYYCR--IQ
-A-G--SLSKNA-SVK------M--D-VA-----ALGLDP-----------------YI-
------HMENYEAG-QI-Q---L--VCRSLGWFPKPQVQWRDAHG-EILPS---------
--------------------------ET-QYLDKEGLFQMEASVTVR-----D--GSSG-
NLTC-SIWNSA-LGQ-EKKTT--------------------------------LFI----
------------------------------------------------------------
-----------------------------------------------------RAFPSLY
I---T-----P---------------------SA-VGLAVI-LPI-----LGLFIALG--
I-----YIIWKQQRSREKLLYQ--QVVEIE-NLLSDHGKEK-GR----------------
---------------------------------LH-------------KGL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKYRAELKL-----------KRIAADAGWRRARLHPVDVT---L--D-PETAH
PKLL----------LS-----EDLRSVRLGDK----R--QD-V------------PDN--
PKRFNFVVSVL-----------GSPTFI---SGCHY---WE-VC-V------GNKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------ITATPSNGHWLLRQS----------GINEYEALTSPQT------Y
---------------------------------FRLKESPR---RVGVFLDYEGGFVSFY
NATNKSH--IYTFVHSF--S-GPLRPFFEPCLHDEG---KNVAPLIIC-SGS-QNSEEFI
YSNL---------------------------------------------------SPET-
-SKEEKQTLGIGNGKIPTKTDQAPNL--YPLQ---DIVSSWPSDVTPALQGLRAPFF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDRCRH-------------SLLSHLPSL----
LLLFQLPF---AGS---------------------------------------AEE-FVV
--------I-GPS-DPIVAMLGGDVMLPCHLSPAMDMENM-ELRWFRSKF-S---E-AAF
IYQNQQEQREE----QLAQYAGRTSL-VKDFLTQGEA-AMRIHKVQAFDNGLYTCL--FR
-K-G--NFYEEA-NLE------L--M-VA-----GVGSAP-----------------QV-
------RIQGPEED-GI-R---V--MCMASGWFPKPQVQWRALSG-EKFLM-F-------
------S-------------------ET-YAQDAEGLYSVEAALVVR-----D--SSSG-
NVTC-SVLNPI-LGQ-EKVMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQT--S----------------P----WKP-AFMVT-LTV-----LTLLIFGA--
A-----YYTKREHTAKQQERQ--------EREKLHRD-KEEDQQTKEKV-LKDR------
------------GK-AG----QGSR-----PV-SVA-----AGA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------EDEPT---AGPLA---WS-KW-LRRSR-ED---SWSC
GVSMDL---E--L-GL--------------------------------------------
---------------LLGYREVLLWVLQ-V--Q--------SLLFLGM------------
--------------------------------------------RVHAYFPL--------
---------------SFR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIKWSNTKG-ENIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGG-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATE-------------
----------------REIS---------LREKLQE-E---LKWR---KIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMSPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEVSFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-K-VERSP
-N--P--D-----------------------LVPD--------HSLETPVT------PDL
ANESGEPQAEVTSL---LLPAHPGA-EVSPSA--------T-TNQNHKLQEHTEALY---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ANIP
---E-------------------SLEFLKQV-------LLPSR------VFFLIHLLL--
--LPQPGQ------------------------------------------VN-SEE-VMV
--------I-GPG-EPILAHVGEEVEFSCHLSPYQDAKHM-EIRWFRSQA-S---D-VVH
LYPEPQELWAQ----QMTQFQNRTRL-VTEEIADGSV-NLYLRGVLPSDEGPYGCS--FL
-S-D--SFSGEA-LWE------L--E-VA-----GHGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPTVQWSDHQG-QCLPP-E-------
------S-------------------KI-IIQDAQGLFSLETSVVVR-----K--GAHS-
NVSC-SIQNPL-LM Q-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGT--S----------------P----WKR-AFLGT-LVT-LLLLVALLTLLA--
T-----RYFRRQRQFQAKVKK--------QADK-ERE-----------------------
------------------KLQTEL----EWRRAEGQ-----AEWR---TARQYA----VD
I-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----KDGKSVSSSRQGTPNP---G-V------------ACD--
PSRFSEQTCVL-----------SHER FP---SG RHY---WE-VH-V------GSRSRWFL
GACLDSVA-R--S-GH--------------------------------------------
---------------ARLSPARGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALPVRVPPR---RVGIFLDCEAGKLSFF
NVSDGSH--LFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIVSSWP-AGGTRAP
QEQ------DSDTWVQ----------------------------PC-ETP----------
-----DPPW---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MANVT---L--D-PDTAY
RFLV----------LS-----EDGKRVTVGFI----R--QD-L------------PDK--
PERFSDVWCVL-----------GRECFT---SGTHC---WA-VD-V------EDATVWSL
GVCRENVR-R--K-GK--------------------------------------------
---------------ISESPADGLWAVKKE-----------REQYWALTSP-R-----VP
---------------------------------LSLTTSPR---RVVVYLDCEAGDVSFY
SGTDGSH--IYTFPRAAF-S-GTLRPFFRLYYLY--------QSLKIC-PVP-GGEGENP
VPAP----A------------------------QE--------TPXXXXXX---XXX---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------KAD-FSV
--------C-GPG-KAVLAVLGENVELPCHLSLNISAKDM-ELRWYRDQP-S---Q-VVH
LHKNGTDVKEE----QMREYQGRTTF-LSARLDQGKA-TVKIHNVTVFDNGTFHCN--FK
-D-G--TVSAEA-RLL------L--T-VA-----GLGLKP-----------------RI-
------QVRAIQGE-GF-W---A--QCTSEGWYPEPQVRWRDFRG-QALPS-M-------
------T-------------------RL-SASPTTGLFAVVSNVTIQ-----N--KEVW-
GLLC-SI-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MKV
--------I-GPG-EPIVVHLGDDVELPCHLEPKMNAQNM-EVRWLRSQL-F---P-AVH
VYRDGQDQAGE----QMGEYRGRTEL-LKDAINDGSL-TVKIRDVRVSDDGEYRCL--FR
-D-D--EKRDEA-TLQ------L--Q-VT-----APNRAGAGVPIQVSSPPAVGSDSHI-
------RLEGHEVR-GI-R---L--GCMSTGWYPEPQVRWTDASG-ETV-----------
---PSLSE------------------SL-H-RAADGLFSVSTSVFVR-----D--DTVG-
TVSC-SVQNPL-LRQ-VKGA----E---LSIA-V--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
S---HQQV--S----------------T----WVV-VLSVI-VII-----LVLLIAGA--
S-----YLIWMLHREKEHERT--------EKEK------E--------------------
-----------------RMLN----------ESFLA--K--LTWR---EARS--------
------------------------YMV---------------------------------
------------------------------------------------------------
--------------------------------------------DIT---L--D-PDTAH
PQLI----------VS-----EDRKSVARGVT----R--QD-L------------PDN--
LERYDCISCVL-----------AREGFT---SGRHY---WE-VE-V------GVNTGWGL
GVTVENLS-R--K-GI--------------------------------------------
---------------IALRAVQKFWVVG-F--Y--------GEEYWALTYP-K-----TS
---------------------------------LFLSQPLQ---CVGVYLDYEAGYVSFY
SGTDGSH--IYTFSHIAF-S-GTLRPLFHLWTEDPS-------PLTIC-SVP-REAEGNW
PPTG----P------------------------S--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--GL---SFS--------RCF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTV
--------N-SLE-RPVLAALGGKVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--DVYEEA-IAE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDRNKLFNMKMSLLLR-----D--SSHG-
NITC-YLRNPV-TGQ-EERAS-------IVLS-DKLFP-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---VCVITGLTITLHHR---------------NRVPVSDR
K---FQFV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGFF--------------QI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FSV
--------K-RPA-EPIMVLLGTDATLPCQLSPEQSAAHM-QIRWYRSQG-S---P-AVL
VYQNGQELGGE----QMLEYRGRTEL-VADSIGKGAV-ALLIQQVRASDDGQYWCH--FK
----------------------------------DLGSIP-----------------FI-
------EIKGHDDG-GI-R---L--ECKSLGWFPEPHAVWKDPYG-EIMPSLE-------
--------------------------EA-YTMDADGLFKVTIAIIIR-----D--CTVR-
NMSC-SINNTL-LGQ-EKETV-------IFIP-XXXXX----------------------
------------------------------------------------------------
------------------------------------------------------------
------XX--X----------------X----XXX-XXXXX-XXXXXXXXX---XXX--X
X-----XXXXXXXXXXX---X---------------XXXXXXXXXXX-------------
------------------------------------------------XXXXX-------
------------------------------------------------------------
-----------XXXXX--X-----------------------------------------
----XXXXXQLQELRW--------------------RRTLLHAADVI---L--D-PDTAH
PELF----------LS-----EDLRSVKR--GSYR----QS-V------------PDN--
PERFDCRPCVL-----------GLESFS---SGKHY---WE-VE-V------ESVMVWAV
GVCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPENGFWTLEMF-----------GNQYRVLSSPEK------I
---------------------------------LPLKECLR---RVAVFLDYESGDISFY
NMRDRSH--IYTCPHSLF-S-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAKGLT
VPE--------AGLILHRAGTHCCQS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDTW------RSP-----------ALPVLCLTC
LVLVQ-------------------------------------------WPTPWAAQ-FAV
--------I-GPS-GPIVAVVGEDADLPCHLSPATSAETM-ELRWVRSSL-R---Q-VVF
VYADGKQVQDR----QIAEYRGRTSI-LRDGLAAGKA-ALRIHGVRASDNGKYLCY--FQ
-D-G--DFYEKA-IVE------L--K-VA-----ALGSDL-----------------HI-
------EMKGHKDG-GI-H---L--ECTSTGWFPQPQVEWRDASG-KRIPAA--------
--------------------------AAPADADGAGLYTVAASVILR-----G--GSGP-
GVSC-TIRNSL-LGQ-EKSAK-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FSSA--R----------------P----WTS-ALGAT-LPI-----LLLLLAGA--
G-----FFLWRQQKVNKAL---------SAEKEQERVQKEKAQEETE-------------
----------------QERS---------AREKLQY-E---LKWR---RIQYLA------
----------------------RGA-----------------------------------
------------------------------------------------------------
--------KSS--------------------AYADWKAALFQAADVV---L--D-PDTAN
PILL----------VS-----EDKRSLQRAKE----R--QD-L------------PNN--
PERFDWHYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHV
GVCGEKVE-K---KCW--------------------------------------------
---------------VKMTPENGFWAMGLS--D--------EHDYRALTEP-R-----TK
---------------------------------LTLCEPPS---RVGVFLDYEMGEVSFY
NAGDGSH--IYTFPQSTF-S-GPLWPVFRILTLEPT-------ALTIC-PVL-KGTERPL
----V--SD----------------------PAPE--------LPPEPPVT------SCL
ANWREEPQAEGRAP---LLPHSNPL-QL--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MVR
---K---------------------------------SCLP---------RCL-----LT
LVLLQLPK-------------------------------------------LDSAH-FDV
--------M-GPP-EPILAMVGADAELPCHLSPNVSAEHM-ELRWFRRTP-S---P-AVF
LYQAPQEQEREPERELLPEYRGRVAL-RRDDIAAGRA-ALRICGVRASDEGEYRCL--FR
-D-NA--SYDEA-IVH------L--R-VA-----ALGSEP-----------------HI-
------TMEVQESG-EV-R---L--ECTSVGWYPEPQVQWRSAKE-EKFLS-T-------
------T-------------------ES-RSPDEEGLFTVAASVTLR-----D--NSMD-
SMSC-CIRNLL-LGQ-EKEVG-------ISIP-API------------------------
------------------------------------------------------------
------------------------------------------------------------
----SPR-L-T----------------P----WMV-SVAVI-LVV-----LGLLTIGS--
I-----FFIWRLYKERSRERR--------SKFSST-------------------------
-------------------------------EKLLE-EL---NWK---KVALHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----EDAKSVRLEDS----R--QK-L------------PEN--
PERFDSWPCVL-----------GREA FT---EG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMTDGSH--IYTFPGISF-S-GPLRPFFCLWSCG-------KKPLTIC-PVS-EGPEGVT
VIPE----A------------------------QN--------LSQDIPLS---RVGQDS
ASGDTHT---LRSK---LISSQPSRG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TAF--VL
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------T-GPG-KFVQAWVGEDAVFSCSLFPETSAEAM-EVRFFRNQL-H---A-VVH
SIEGEDVWRKR----QCVQYRGRTEL-VKDSITG-------TKNITPLDVGLYGCW--FS
SQ----IYDKEA-TWE------L--Q-MS-----ALGSFP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTVKWKGPQG-QHLSSDS-------
---------------------------R-ANADGHNLYDVETSIIVQ-----E--N-AG-
SISC-SIHLAE-QSH-EVESK-------VLIR-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILPGLLC---GGLCGVVVGM--
-----TIVFFKSKGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELREARKHAVEVT---L--D-PATAH
SQLC----------VS-----D-LKTVTHRKA----P--QK-V------------PYS--
TKRFT-RKSVV-----------ASQGFQ---AGKHY---WE-VD-V------GQNVGWCV
GVCQDDTD-R--R-KDS-------------------------------------------
---------------VTLSPNNGYWVFGLT--T--------EYLYFTFNPH-F-----IN
---------------------------------LSPETPPT---RVGVFLDYEGGNISFF
NTNDQSY--I-CILTCQFEG-L-LRPYIQHVISE-K---KNGTPIFIC-PVS-WD-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------LN-SE--VKV
--------L-GPE-YPVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKPQWRDHQG-QCLSP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--P----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRCQEKLKK--------EAEK-REG---ER------------------
-----------------------------------G-----PDWR---RAEGQA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------PSD--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGVFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-GVLCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPT----------
-----DPAPD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FTV
--------V-GPA-DPILVLVGENITLRCHLFPEKNAQDM-EVRWFRSQF-S---P-AVL
VYKGGQERNEE----QMAAYRGRTTF-VSENIQRGRV-ALVIHNVTAHENGIYRCY--FQ
-E-G--RSYDEA-VMR------V--T-VA-----GLGSPP-----------------LI-
------EMQVLEDG-GI-W---L--ECTSGGWYPEPRAVWRDPYG-EVVQALE-------
--------------------------EA-YVVDTDGLFTVTLAVIIR-----D--CTVR-
NMSC-AVNNTL-LGQ-EEESV-------IFIP-EPVVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------S----WTP-AAG---RPTG--SAA---SAA--S
I-----CLIKKLHKDKEP-ME---------------KEGE--------------------
------------------------------------------------------------
------------------------------------------------------------
-------------SEE--T-----------------------------------------
----DDAEQLQEELRW--------------------RRTLLNAADVL---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPGR----QS-V------------PDN--
PERFDCRPCVL-----------GRESFS---SGRHY---WE-VE-V------ENVMVWAV
GVCRDGVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------EGQYRVLSSPEK------I
---------------------------------LPLRERLR---RVGVFLDYESGDVSFY
NMRDRTH--LYTCPRARF-S-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
VPE--------TGLILYRTGTQHESQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------MKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG-EVVPALE-------
--------------------------EA-YTAGTNGLFTITLAVIIR-----D--DSVR-
NMFC-SINNTR-LGQ-AVEAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------RT--S----------------P----WMV-ALAVI-LPTLILL-----MAG--V
V-----CLVKKLQKEKEV-LAMEKEVLA-VEKEDEREEKEIAWKKLW-------------
------------------------------------------------EERL--------
------------------------------------------------------------
-------------KE---V-----------------------------------------
----SFSKQLQEELRW--------------------RRTVLHAADVV---L--D-PATAH
PQLL----------LS-----EDHRSVFR--GTRR----QE-V------------PDN--
PERFDRWPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVRAWAV
GVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGGGVWALELF-----------GGQYRPLAAPAL------L
---------------------------------LPLRGRLG---RVGVFLDYEAGDVSFY
HMRDRSH--IYTCPRAAF-A-APLRPFFFLGSEDSL-------L-SVC-PVF-VGAQGVT
VPE--------AGLVLHGAGARHGP-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------V---------
------------------------------------------------------------
------------------------------------------------------------
-------EKLQTELEW-----------RRTEGQAEWRAACRYAVDVT---L--D-QDTAH
PMLQ----------VS-----EDRKSVTYGDT----K--AD-L------------PGD--
PKRFENCPCVL-----------GQEGFI---SGRHY---WE-VE-V------GQKTRWFL
GVCQDAVE-R--K-VE--------------------------------------------
---------------VRMSPGTGYWVLGLW----------NSAEYFILDPYRV------S
---------------------------------VTLRVPPR---RVGVFLDYEGGRVSFF
NVTDGTH--IYTFTATF--S-GTLRPYLRPRSHDGG---EHAAPLTVC-PVP-GRPEAVD
DCDT--------------------------------------------------------
---------WLQPY-------DTP-------D---TILGQW-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------SGL-FHV
--------I-GPR-KPVIALVGGEALLPCHLNPSMDAQHM-EVMWHFNHL-S---E-VVH
YYGNFQDDLQQ----QSTEYQGRTEL-LKENITKGQV-TLRIHPIHVSDEGEYSCS--FA
-S-S--THSDEA-QVE------V--M-VT-----ASGIDP-----------------HI-
------HIEPRSTR-GI-K---L--TCKSMEWYPEPEVQWGDPKG-QPLTP-E-------
------T-------------------ET-MTKEENGLVLVESSITVD-----E--TSGE-
NLFC-FIRNPV-LNV-EKGAY-------LSIA-R--------------------------
------------------------------------------------------------
-----------------------------------------------------------E
F-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFS
---N----------------------------------FLL---------GCL-----LT
LMLLQLPT------------------------------------------LDT-AP-FEV
--------L-GPL-EPILALLGEDSELPCYLSPSMSAEHM-ELRWFRNTF-S---P-AVL
VHQDGQEQEGE----QMPEYQGRVTL-VTENITAGHA-MVRIHGIRTFDEGVYGCS--FR
-D-DQ--VRGEA-FLQ------L--R-VA-----ALGSDP-----------------HI-
------GMEVQESG-EI-W---L--QCTSVGWYPEPHVQWRTPTG-EKFLS-T-------
------S-------------------ES-KSPDQDGLFTVAASVIIR-----D--TSLE-
NVSC-CIRNLL-LGQ-QKEVG-------ISLS-APS------------------------
------------------------------------------------------------
------------------------------------------------------------
--------S-P----------------F----WSF-SM------V-----AVFMGFVG--
I-----FIIWQLYRKCRKKER--------NDEIS--------------------------
-------------------------------------PI---EWK---SARSY-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVPVT---L--D-EDTAH
PHLL----------LS-----EDLKSVRLEES----R--HD-R------------PEN--
PERFDSWPCVL-----------GKKP FT---SG KHY---WE-VE-V------GDRPDWLV
GVCREDVM-K--K-GF--------------------------------------------
---------------ILMSPKNGFWVVELS-----------GKEYWALAPL-R-----VL
---------------------------------LSLPEAPR---QVGIFLDCESGTVSFY
NVNDGSH--IYSFPKVSF-S-GPLLPIFCLWSCD-------KKPLTIC-PVAADGPVEVT
VMAD----A------------------------QT--------HQR--LLP---PMGQ--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------WMRM-ASSS-----G-----SWLLGCLL-----T
L-FLQVSA-------------------------------------------QV-------
--------S-GDAGGFHLTRLGDTAELPCPLALWPGSVPE-EVRWQRPSRLQ-RPQ-AVH
VFRRGESRDED----LMPQYAGRTEL-VENA-QEGSV-ALKIHNVSLEDRGPYQCQ--IR
-I-R--NLSREG-SVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----P---------------------SA-VALAAF-LPV-----LGLLIIAG--
I-----CLIWKQKRSKEKLLYE--QAMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PETAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PHRFDFVVSVL-----------GSEC FT---DGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RELHYEALTSPQT------S
---------------------------------FRLKEPPK---CVGIFLDYEAGIISFY
NVTDKSH--IFTFSHSF--S-GSLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEESI
VPKS---------------------------------------------------EGKS-
-YANGDV--KVNPS---LLPTQGPEL--FPLK---DTIVSWHSDLGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------LVN-APFSLKGK---PSLFKRVI
LWVYFKGEFTVLEPQQP-IKALVGEEVTFHCGLCPQKNAGNMEVMWFHEKPSNVI-HRYK
DRQDQKYSQLPKYTGRTKFLRE-SISRGNVALRLHNIHLSDEGKYFCQFTSCIYS DKTEF
QVYVAGMGSDPNIHIN---------V----KG---------------------------I
NIWLMCTSTCWY----------PKPE---VQ---WRNSHGKPL-----------------
-TPASESVKQEDN--------------------------------G------------LF
FVKSSIMVLANS----------------------------------EE NFSSVIRN----
PFSTNRRKI------------------------S--SPSVA--PITQK-IHTVLGK-FTV
--------I-GPQ-Q-VIALVGGEAILPCHLSPQMDAQDM-DVMWFYGES-S---L-LVH
QYKDRQDHLNH----QHQEYKGRTEF-LRDDISNGSV-ALKLHHIRPSDEGKYRCF--FE
-S---SSASGEA-EYQ------V--Y-V--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VEM-ASCT-----S-----FPLSSCLI-----A
LLSLQMPT-------------------------------------------EGSGH-G--
--------T-GKVDKRNLVILGTKAELRCPLSFWMAPESI-EVKWLRTQKSQ-ASQ-VVH
IYQNGQDLYGE----QIPQYKGRTAL-VKDN-KEDNF-ILEIYNVRLEDQGQYYCQ--IQ
-T-G--SLSKNA-TVK------L--E-VA-----D-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------PFV
I---I-----P---------------------ST-VGLTVI-LPL-----LGLLVAVG--
I-----YIIWKQRRSRXXXXXX--XXXXXX-NLLSDHGKEK-GR----------------
---------------------------------LH-------------KGL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKHRAELKL-----------KRSAADAGWRRARLHPVEVT---L--D-PDTAH
PKLL----------LS-----EDLRSVRLGDK----R--QN-V------------PDN--
PKRFDFVVSVL-----------GSPSFT---SGCHY---WE-VC-V------GDKTKWVL
GVCSESVS-R--K-GK--------------------------------------------
---------------ITASPSNGHWLLRQS----------RMNDYEALTSPQI------S
---------------------------------FRLKDSPR---RVGIFLDYDAGFVSFY
NATNKSH--IYTFTHTF--S-GPLRPFFEPCLHDEG---KNVAPLIIC-SES-QSSEEFI
YSKL---------------------------------------------------ER---
----DKVTAGTGNGSIPTKAGR-------TLQ---DIVSSWPSDVTPALQGLRAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MANFL
---VS-------------------MEFLKRV-------PLPSS------LLILTQL----
LLFLQLGK------------------------------------------AD-SGK-VKV
--------V-GPG-ESMLALVGEEVEFSCHLSQYMDVEHM-EILWFRGQT-S---D-VVH
LYQDGQELFGG----QMVQFQNRTKL-LTDEMAIGSV-ILQLHNVVPSDQGPYGCS--FL
-S-S--SFSGEA-IWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPQALWRGHQG-QCLPP-E-------
------T-------------------EA-IVQDVRGLFHLETSVVVQ-----G--RAHR-
NVSC-SIQNPL-LIQ-KKEFV-------VQIA-GQLDNFVSTYLGYGIIP----------
------------------------DFYFILNIFLYYGLRAQDRAACPSAPT---------
------------KGRG-----------------GGVTTQGAARGVWS--LIWVSWCFPDE
F---FPGA--S----------------P----WRS-AFLGT-LAA-ALLLLLFLAALA--
R-----LQ--RRHRGER-LGR--------GRR----------------------------
-----------------------------CR----G-----RGRG--------R----RS
A-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------Y---S--L-SKVTH
PNLE----------IS-----EDGKSVSTRPG---P---PS-P------------VAS--
DPWFSQHKCVL-----------GREQFS---SGRHY---WE-VH-V------GRRSCWFL
GVCLAAVP-H--S-GP--------------------------------------------
---------------ACLSPASGYWVLGLW--N---------CEYFALDPH-R------V
--------------------------------ALTLRVPPR---RVGLLLDCEAGTLSFF
NVSDGSH--IFTFSDSF--S-GALCAYFRPRAQDGS---EHPDPLTIC-SLP-IKDTCTL
EDN-------SDTWLQ----------------------------PL-TLS----------
-----DPTQV-------L------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
---------------------MVGESSTLRCHLSPEKSAEAMEVRWFRTHFSPAV-LVYR
GGQERPEEQMQQYRGRTSLEGA-GLGRGRAALVIHNVTAHEDGDYSCSFQEGRSYDEAIV
R LEVAEIFVFFQTPGHPELSRAESEMPFRRGTRRQEVPDDPERFDLWPCVLGLERFS SGR
HYWEVEVEDVMVWAVGVCRADLPRKGEVAAGGGVWALE----------LFGGQYRPLAAP
ALLLPLRERLGRVG-----VFLDYEAG------------------DV----SFYNLR DDP
---TLKLGEPHA----------QGVCTAPWT-RLDS-AYSPPL-QYTFLLSLLSFL--TA
PLSTQLPN-------------------------------------------IDMIK-F TV
--------Q-GPS-EPVLAMVGESSTLRCQLYPEKSAEAM-EVRWFRTHF-S---P-AVL
VYRGGQERPEE----QMQQYRGRTSL-EGAGLGRGHA-VLVIHNVTAHEDGDYRCY--FQ
-E-G--MSYDQA-IVH------L--E-VA-----GLGSKP-----------------LL-
------EMKCQEDG-GI-R---L--ECTSPGWYPQPHAVWRDQSG-EVVPA-L-------
------E-------------------EA-YTAGADGLFTVALAVIIR-----D--DSVR-
NMFC-SINNTR-LGR-KVEA----G---IFIP-ENEGA----------------------
------------------------------------------------------------
------------------------------------------------------------
-------N--P----------------S--M---------I-HPH-------SNNEAS--
A-----CLTK--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------Q---L--D-T----
------------------------------------------L------------TDE-F
ERRQPWGCITI-----------GQECLP---APRRT---WG-TL-Q------RELETWRA
QVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGDGVWALE-L--F--------GGHYRPLAAP-A-----LL
---------------------------------LPLREPLG---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRAAF-A-GPLRPFFLLG-SDDS-------PLAVC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

---------------------------------------SFPASSLPCC---IFSLFLLQ
LPSQNSAQMKVIGPGEP-IKVQVGGDAKLNCYLEPKKDAQHMEVRWFRSQFSLAV-HVYE
RGQDQTADQMKEYQGRTELLKD-TITDGNLTLKISPVRVSDDGEYRCYFDDEGDNEETTL
QLQ VTAVGSEPQLRLE---------GH---EM---------------------------K
GIW LGCMTTGWY----------PAPQ---VR---WKDARGQMV-----------------
-PSWSESLSQDTD--------------------------------G------------LF
AVKLSVLVQEAF----------------------------------EGTVSCSLES----
PLLP QGKE------------------------------AGI--SIAES-SLVELTQ-MKV
--------I-GPG-EPIKVQVGGDAKLNCYLEPKMDAQGM-EVRWFRSQL-S---P-AVH
VYEHGQDQTGD----QMKEYQGRTEL-LKDTITDGNL-TLKISPVRVSDDGEYRCF--FQ
-H---GGNSENT-TLQ------L--Q-VT-----AVGSEP-----------------QI-
------RLEGHEMK-GI-W---L--GCMTTGWYPAPQVRWKDARG-EMVPSWS-------
--------------------------ES-LSQDTDGLFAVKLSVLVQ-----E--GFEG-
NVSC-SLESPL-LPQ-GKEAG-------ISIA-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

-------------------------------------MVDFPGYSLSGV---AASFLFVL
LSMRQSDDFRVIGSARP-VLAVVGEDAVLTCQLLPRRTAAHMEVRWHRSEPSTPV-FAYR
DGAEVTGTQMEGYRDRAEWIQD-NIAEGTVALKIHSIQPSDDGQYWCRFQEGNYCGETSL
WLRV AGLGSA PYIHME---------ES---VE---------------------------N
GVQLVCTAKGWF----------PEPQ---VS---WQDITGEKL-----------------
-LTVAEHHVQDED--------------------------------G------------LY
YVESTLVVRNPL----------------------------------PEAVSCFIHN----
PTLTEE KG------------------------------SHI--SIPEK-LQAELAS-LKV
--------I-GPS-QPILVRV GEDIRLTCSLSPKTNAQSM-EVRWVRSHR-Y---P-AVY
VYMDGDHVAGE----QMAEYRGRTVL-VSDTINEGRL-TLQINNARISDDGQYQCL--FE
-K---DGVYQEA-NLD------L--K-IV-----GLGSSP-----------------LI-
------SVGEWKDG-EI-K---L--LCTSEGWFPQPHVQWRDVEG-KAIPSFS-------
--------------------------QD-LTQGSHGLFRVEAFLLIT-----N--SSTV-
NVTC-SISNPL-LGE-EKVTA-------FSLS-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------L-GPG-KPVQALVGEDAVFSCFLSPETNAEAM-EVRFFRGQI-S---S-VVS
LYRKGKEQPSM----QMPQYQARTKL-VKDSIAEGHV-SLRLENITVLDAGLYGCW--IG
SQ----SYHQEA-VWE------L--Q-VS-----ALGSVP-----------------LI-
------SMVAYVDR-GI-Q---L--LCRSSGWFPRPTAKWRGPHG-QELSTDS-------
---------------------------R-THTDMHGLFDVEISLTVP-----E--N-AG-
TVSC-SVQHPH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WAL-AVKVLGILC---SGLFFGIVGL--
-----KIFFSQFQGK----IQ--------AEL----------------------------
------------------------------------------DRR---IKCG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELREARKYAVKVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRMA----L--QE-V------------PNS--
AKRFT-RKSVV-----------ASQ SFR---AG KRY---WE-VD-V------GYSTHWYV
GVCRDDVD-R--K--KY-------------------------------------------
---------------VTLSPNNGYWVLGLQ--R--------E--HFTFNPH-R-----IS
---------------------------------LFPRIRPT---QIGIFLDYEGGTISFF
NINDQTL--IY-TLTWRFEG-L-LRPYIEHQ----F---RDGTLTVIC-PLP-QESEREA
SSQR---------------------------------------------------ASTTP
EACNSESSSQVTTP---FLPRSDE------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VF
ISVLSFY-------------------------------------------KLVSGQ-WQV
--------K-GPD-KFVQASVGEDAVFSCSLFPETSAKAM-EVRFFKNQL-H---A-VVR
LYRDGKDLESM----QMSQYQGRTEL-VKDFIARGNV-SLRLKNITPSDIGLYGCW--FS
SP----TYDEEA-TWE------L--Q-AS-----GWGSLP-----------------LI-
------SMVGYVDG-GI-Q---L--LCLSSGWFPQPIVQWKGPQG-EHLSSDS-------
---------------------------R-ANADEHSLFDVETSLTIQ-----E--S-TG-
SISC-SIHLAE-QSH-EVESR-------VLIE-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ACILLVLVC---GGLCVVITGM--
-----AIVFFRSKEL---REA---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------RKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTRTRT----P--QE-V------------PYS--
KKRFT-RKSVV-----------ASQG FQ---AG KHY---WE-VD-V------GYNKWWYV
GVCRDDVD-R--K-ETR-------------------------------------------
---------------ATLSPNNGYWVFRLM--R--------EDWYSTFDPH-V-----IT
---------------------------------LVPKTPPT---RVGVFLDCEGGTISFF
NINDQSL--I-C------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FHV
--------I-GPR-KPVIALVGGEALLPCHLSPSMDAQDM-EVMWHLNHM-S---G-VVY
YYGNFQDDLQQ----QSPEYQGRTEL-LKENITKGQV-ALRIDPIHVSDEGEYSCS--FA
-S-S--THSDKA-QLE------V--M-VT-----ASGIAP-----------------HI-
------HIEPRSTR-GI-K---L--TCKSTGWYPEPEVQWRDPKG-QPLIP-E-------
------T-------------------ET-MTKEENGLVLVESSITVD-----E--TSGE-
NLSC-FIKNPV-LKV-EKGA----Y---MSIA-H--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---FPQV--S----------------P----WTV-GLSVLVGLL-----VLIMMIVS--
V-----LLWRTRKDRGKWE----------KNGEED-------YGRLTEEV---GK-----
--------L---------------------------------------------------
------------------------------------------------------------
--------------MISSEYRP--------------------------------------
--------LVAPAPEW-HM-------------------AKTNSEDIK---L--D-DATAH
PSLA----------VS-----EDGKSVKSLSQ----M--QD-V------------PDN--
PERFDSMEAVL-----------GQNSFS---SGQHY---WE-VD-V--RG----KNLWKI
GLCLDSVK-R--KGVI--------------------------------------------
----------------LTSPENGFWVLS-L--L--------DGEYLALSKP-P-----IC
---------------------------------LNVPTPPS---KVGIFLQYKQGLISFY
NLSDSSI--LYTFKS-NF-T-RALKPYFNP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENCCKPS-----LLF---HIL-CLL-------
-VLTQMTS---LVT---------------------------------------AKD-FLV
--------F-GPS-DPIVATLGGEAILPCSVFPVMSVENMEELRWFRTRF-S---E-AVF
VYRDQEEQKEG----QLPGYSQRTSL-VKDQFHEGKA-AVRIQNVQESDSGIYVCH--FK
-Q-G--HFHEEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEEG-GV-C---V--VCMTSGWYPEPQVHWRDSRG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTETSLVLR-----D--SSVR-
NVTC-STFNPI-LGQ-EKAMA-------MVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-DISEI-LKM-----ILILISGT--
I-----YLLRREHSGRLKVQQ--------KRKHLQCE-KDELQTTKEDA-LLFT------
------------RL--FEWGYFDWV-----LTRVCS--F--TAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQAC-------------NFT---L--D-PASAH
PILN----------VS-----QDRMRVTRKDTTM--C-----------------------
---LDDLFCVL-----------GTNGIS---SGRYY---WE-VK-LRNRD-SS---TWTL
GVCREGVE-R--K-GC--------------------------------------------
---------------FSECPEKGFWTVG-Q--S--------SSGYWAYVDSGR-----DS
---------------------------------LSIRQAPQ---SVGVFVDYDERNISFY
NMSDKSH--LFSFHEASF-S-GTLLPYFRLKSGN-I-------SMTVS-SMA-CVSEGQQ
GEEG----RRGRKRSRK---GRKGRRPKKGKGLAL--------LPLKESLSPTGEEGLVP
GSCVVVSPSGEESP---FLQDARDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------SHRVCS--L--TAWR---KAQLYA----AG
VK----------------------------------------------------------
------------------------------------------------------------
---------EINALDW-RQ------EKFQAW-------------PVT---L--D-PGSAD
SSLV----------VS-----HERRSVALKEA-C--E-----------------------
----DSGGSVL-----------GLEGIT---AGRCH---WE-VE-VPYGD-GS---EWFL
GVCREDVE-R--T-GW--------------------------------------------
---------------YTESPEKGFWVVG-Q--F--------EAGFCPCTKDPT------P
---------------------------------LPLRQLPR---RVGVFLDYSEGDVSFY
NMTDGSH--IFSFPRASF-S-GTLFPYFRLKSGV-G-------SLTIC-PMA-GAPEGLP
VPLN----N------------------------SP---------SFEEPVSP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AAPHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAP-FTV
--------V-GPA-SPILAMVGENTTLHCHLSPEKNAEDM-EVQWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRVTF-VSKGISRGSM-ALVVHNVTAQENGIYRC-----
------RSCDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECVSGGWYPEPLTVWRNPYS-EIVLTLK-------
--------------------------EV-SIADAEALLVVTTAVIIR-----D--KSAR-
NVSC-SIKNTL-LGQ-EKETV-------VFIP-ESFMP-------STSPWMVALAA----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSE--------EKEVEQEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------RRTFLHAA--L---T--N-PNTTH
PELF----------LS-----EDRRSVRR-------------------------------
-ERFDSQPCVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTM
GVCGDSVE-R--K-RE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCTRSAF-S-VPVRPFFGLRSDDSP-------I-FIC-RAL-TGASGVT
VPD--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------M-----VFCRH-----------------------------MTTRERS
---STMSGAQAS----------LSPAAMANT-QGRD-IFPPSC-S---II---FLL--LK
LLSYSLSA-------------------------------------------KGKAD-FSV
--------S-GPG-QPVLAMVGESVKLQCHLSLNISAEDM-EVRWYRKEP-S---P-AVH
LRKKGRDMPEE----QMWQYKGRTTF-WTAGLAQDQA-VLTIRNVTVFDNGTFHCK--FK
-E-S--TGSAEA-TLW------L--R-VA-----GLGSEP-----------------RI-
------QVRAGQDE-GI-R---A--ECTSEGWYPEPQVEWRDFRG-QTLPS-T-------
------T-------------------NL-TVSPTTGLFAVVSNVIVW-----D--RDVG-
NLSC-SISNPL-LQK-RMET----K---SHLP-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
V---PKNF--P----------------S--MAWRA-VVPVI-LIV-----VGLAAA----
-------VLWQEPPVFSGNV----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------RGTGIGCSW-K-------------------KR-D-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYSDGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNTKG-QHIPSV--------
--------------------------KAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATK-------------
----------------QEIS---------LRGI--------QKWR---KIQ---------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------YMAPDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPW---KVGIFLDYETGDISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--G-----------------------LVPD--------HSLETPVA------PDL
ANESGEPQAEATSL---LLPAHPGV-DGLALH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLILL----
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAKVGENTMLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALIIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GIVPALK-------
--------------------------EA-VTPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SISDTL-LGQ-KKESV-------IFIP-ESFMP-------SMSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EMESEWKRREIAEKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KG----KRGW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFNSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-EE--------------------------------------------
---------------VLLRPRNGFWTLEMC-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRLAF-S-VPVRPFFRIGSDDRP-------I-FIC-PAL-TGASGIT
VPE--------EGLILHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARP-HHGDAATLPSF----LVT---FIF--LQ
LLPAG----------------------------------------------NGKSD-FRV
--------L-GPP-DPLLAIFGQDKELLCKLSPNISAEGM-ELRWYRDQP-S---T-AVH
VHKNGEDVYEE----QMVEYRGRTTF-VGNHMVRGEA-AVRINNVSIVIEPTKQLQDIPM
-E-A--TVATGS-ELM------S--L-PS-----GLGSSP-----------------RI-
------HVTDTQDK-RI-R---A--ECTSTGWFPEPKVEWLDLRG-QPVPA-E-------
------T-------------------HF-SATASTGLLTVVSIVTTK-----D--RAVE-
GLTC-SITNPL-LPE-KKVA----E---TYLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---FRMP--L----------------S--AERVP-VLPLI-LAA-----LGLVTAAI--
A-----CAFGRRHKEDKSEEE--------EEVDPR-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AS-A-------------------EVEPFHDS LS---L--D-PETSS
PKLV----------VS-----ENQKSVKRLLF----D--QD-L------------SPS--
SKRFDQDPCIL-----------AQEQ FD---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TH
---------------------------------LSLPQPIC---RVGIFLDFEAGKISFH
NAVNGFL--IYVFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-RETEEVT
DSSE----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MMTFP
---V---------------------------------SSQG---------RY------LI
FLFIQLPM-------------------------------------------LDSAR-FDV
--------I-GPT-EPILAMVGEDIDLPCHLSPNISAKNM-ELRWYRKKI-S---P-AVY
VYQKEKDQGGD----QIKEFQGRTTF-VQDNITEGNV-AVTIHNVRASDDGQYRCF--FK
-D-DQ--MYEEA-IIE------L--K-VA-----SLGSDP-----------------HI-
------HMEAYGDE-GI-L---L--ECTSVGWYPVPQVLWKDLKG-EILPL-L-------
------S-------------------LS-QTPNEDGLITVEASVAIR-----D--YSVG-
SVSC-SIRNPL-LNL-EKVVR-------ISIP-DPV------------------------
------------------------------------------------------------
------------------------------------------------------------
----FSR-L-S----------------P----WIL-SMAVI-LTA-----LGLLTIGA--
I-----FFIWKLHRNKNGEKE--------NKSLSK-------------------------
-------------------------------EKLQE-EL-TTGWK---KAQLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VNVT---L--D-PDTAH
PHLF----------LY-----EGLKSIRLEDT----R--QK-L------------PDK--
PERFDSWPCVL-----------GREGFT---SGKHY---WE-VE-V------GDRTDWAI
GVCKENVT-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLTGPPR---RIGVFLDYESGHISFY
DMTNGSH--IYTFPQASF-S-GTLRPFFCLWSCG-------KKPLTIC-PIF-DGPDEVT
IIAN----P------------------------PI--------PSKKSLVT---PTSEKS
ILWDTDSPQSSNSK---IFPIQPNNG--VL------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------GA-----AVW-----AERKRW----IL
-PMLSLSL-------------------------------------------FFTAQ-FSV
--------I-GPA-EPVLALEGGDTEMSCHLNPKKSAEFM-EVRWFLFQP-S---N-VVH
LYDSGVELFGE----QMKEYQGRTEL-VRDTMDYGRV-AVRLHSVRASDEGNYHCS--FS
-D-G--ISADEA-PLE------L--Q-VV-----AGKDSRPDR---------------E-
----------GRDR-----------QIRKTDPQPHTYNPQSGRVF-PQE-----------
-KEP--TNPLTLS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------P
I---THAG--G----------------------ET-IGSRE-TPV-----LGCTIYGS--
F-----LGQWVSSRGASPLLY--------------VQETDLL-----QPHFNPCQPTPS-
SPVLMMMIEIPIGA------------------HLPR--A--PNAH---PHTL--------
------------------------SAA---------------------------------
------------------------------------------------------------
--------------------------------------------NVT---L--D-PDTAF
RLLV----------LS-----EDRKRATVGYK----L--QD-L------------PNN--
PERFTGLP----------------VCFT---SRRHC---WA-VE-V------GEATVWSL
GVCRENVR-R--K-WE--------------------------------------------
---------------ISESPTDGFWAVK-E--D--------DGEYWALTSP-R-----VP
---------------------------------LPLTTSPS---RVVVYLDCEAGAVSFY
SGTDGSH--IYTFPRAAF-S-GALRPFFCFYR-GYE-------SLTIC-LVP-GGAGENP
VPD---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------LVGDVAKLSCLLTPPQSLANL-EVRWFRGSY-E---F-VVL
LKEKGVDQPGP----QLPQYRGRSHL-LSGDNGDGVV-TLQLKDLRPGDEGNYTCF--FR
-S-R--DFYEQA-VVE------L--N-VT-----GLFFPK-----------------F--
--------------------------------------------S-YCLMS---------
---------------------------------------LAV------------------
----------L-LAI----F----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------LS-LILLV--
A-----FLFWKHWKSREKLLA--------DRGVYCKGQEDELA-GEKW--W---------
-----------------VNLSGKR----GWGRGKGMEEIPSKGFQ---RARTYS----VE
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PSTAH
PNLI----------LS-----PDLRSVTCGV----KP--QD-V------------TPG--
PTRFSHCAMVL-----------GAQVFS---AGRSY---WE-VE-V------GEKTRWAI
GVCLEAAN-R--Q-GE--------------------------------------------
---------------ITLSPKTGYWAAYLR--N--------GDEYMVLTSP-W------T
--------------------------------TLHVRERPR---RVGVFLDIPAGELSFY
NVNARSH--LYTFTGLP--A-KPLRPYLYPYHADGG---QNAGPLTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------IEM-ASSA-----G-----SWLSGCLM-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------LN-SE--VKV
--------L-GPE-YPVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKPQWRDHQG-QCLSP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--P----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRCQEKLKK--------EAEK-REG---ER------------------
----------------------GP----DWRRAEGQ-----AGDV---ILASHP----PG
E-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------G---I--Q-AASN-
-------------------------STTTL---NA-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------METT--GL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------ISSSG--MTL
-----------------SLTLTGLVELSCQLSPPQSAEHM---------E-I--------
--RWFRNLYGE----TISKYVEQTEL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--NVYEEA-ITE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNSK-GL-L---V--ECNSEGWFPQPQMEWRESKG-EIIPP-A-------
------S-------------------KS-HSQDRNKLCNMKMSLLLR-----D--CSHG-
NITY-YLQKPV-TGQ-EERTS-------IVLP-DKLFP-------WNSIWILILVAILAV
LLV-FIMLPSVEL-QQREQRNASTP---------------------------------IT
NNYNISSSSGNWCIGIVFFS---MCVIVGLIIGLHRR---------------NRGMWIKR
M---GTS-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENHRKPS-----LLF---HVS-CLF-------
-VLTQLLS---WVT---------------------------------------TKE-FLV
--------F-GTS-DPIVVELGAEAFLPCSVFPAMNVENMEELRWFRSRF-S---E-AVL
VYRDQEEQKRE----QMPGYSQRTLL-VKDQFHQGTA-AVRIQNVQTSDSGIYICH--FK
-Q-G--VFYDEA-ILE------L--K-VA-----V-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------LGT--
S-----YLLIRERSARLKKQR--------DRVNLQHV-KDELQKTNEDA-L---------
------------SF--NDALMVEHA-----RRKAAY--M--AAWR---KAQLYA----VL
YG----------------------------------------------------------
------------------------------------------------------------
---------DPGGDIF-SG------EHFEAC-------------TFT---L--D-PASAH
PILA----------IS-----LDRLSVSRKDSTL--C-----------------------
---LDDLFCVL-----------GIRGIS---SGRHY---WE-VK-LRNGD-SS---KWTL
GVCREGVD-R--K-GC--------------------------------------------
---------------FSECPHKGFWTVG-R--S--------SSGYLAYIDSGR-----AS
---------------------------------LSVRQAPQ---SVGVFVDYTEGDISFY
NMSDMSH--MFSFHEASF-S-GTLFPYFRLKSGN-V-------SMIIS-SMA-CASEGRE
GEEG----RRGRRRSWKG---SEG---KKGKKLVL--------LPLKESLSPAG-EGLVP
GSCAVDSLPGEDSS---FLQHARNSL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MKVLSIC
---HC---------------------------STAS-SSLP-E-----------FI--IF
FIMFYVHK-------------------------------------------LESAR-FAV
--------V-GPG-HPVTAIAGGDIMLPCRLLPSMSVENM-EVRWFQHEF-T---S-FVH
LYRHGEEEFGQ----QMAKYRDRTKL-SKADITDGIV-DLKIIEVRPSDEGQYRCF--VG
-D-G--DFHDEA-VLE------L--K-VA-----ALGSAP-----------------RI-
------SVAGHQDG-GI-R---V--VCQSAGWYPQPQVLWRDSKG-QPLSA-L-------
------T-------------------ET-KAEEEGGFFKIKNSIVIT-----E--NTKK-
NLSC-SLRNTH-VDQ-EKESI---T---FSIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WMV-VWSVT-LVI-----LLVSIGLT--
L-----FLFKLR----GKALL--------G-G---GS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------VMGIE------------------------NIENCPYETI---L--R------
--------------LA-----DVGK-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------V
--------I-GPS-HPILVRVGEDVELTCYLSPKVNAQNM-EVRWVRSHC-Y---P-AVQ
VYVDGDHVAGE----QMVEYRGRTAL-VGDAIHEGRL-TLQIHGARTSDDGQYRCL--FE
-I-DD--VYQEA-SMD------L--K-VV-----GVGSSP-----------------LI-
------TMEGLKDG-DM-Q---L--MCTSDGWFPQPLVQWMDRQG-EAMPS-F-------
------S-------------------EA-LSQDSRGLFHVETALLVA-----R--SSIV-
NVTC-SISNPL-LGE-RKT-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------I-S-MVSSMGP-------------LGLRSLPSL----
LLLTQLPT---WGS---------------------------------------ADE-FQV
--------I-GPS-DPIVAELGGDAILPCSLVPAMNAEDM-ELGWFRTKF-S---E-PVF
IYRNRQEQNRE----LMPQYAGRTSL-LRELLTQGQV-VVHIQKVQASDNGMYVCF--FK
-T-R--SYYEEA-TLE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGQEQD-GV-R---V--LCEASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEVALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGS-LTL-----LGLLLFGA--
G-----CFTRREHSAKLQERE--------KREKLRWD-KEEDQRAEEEA-LKAR------
------------DE-LQ----VDLG-----RRKTAY--L--AAWR---KAQLYD------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFQAC-------------SVT---L--D-PGSAH
VGLA----------MS-----PDKKSVNWTD-PS--V-----------------------
--GLTDTSSAL-----------GLEGIT---SGRRY---WE-VE-IRSGF-AS---KWAV
GVCREHVT-R--T-GW--------------------------------------------
---------------YRESPDEGFWVVG-W--F--------YNRYFAWTKP-W-----QP
---------------------------------LFLRQNPR---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFPPASF-S-GTLFPYFMLR-GD-V-------TLSIC-PTE-GGSEGLP
VPLS----K------------------------SP---------SLEEAVRP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MNLLLVF
------------------------MNRFKDMFN-I--STLSFF-Q--VSKTFKHHL--LL
MFVVSLI-------------------------------------------DLGSGH-FQV
--------I-GPD-KPIQTLVGEDILFSCHVSPMLNLENM-EVRFFRNQF-S---S-LLV
LYKDGKETKER----QMQEYQGRTQF-VQDAIPEGRV-SLKLKNIILSDAGIYGCR--FS
SQ----TFYQEY-TWE------L--Q-VA-----ALGSTP-----------------LI-
------SLEKYITS-GI-L---L--KCQSTGWFPKPTVQWKNHQG-KHLSSDF-------
---------------------------K-ANTRDDGLFDIETSLTIQ-----E--SSIG-
DISC-SIHTWE-LR---KESR-------VRIA-DPFLQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WIY-GFSIMLA-----IVLIVAVYGV--
-----FLHIR--KGE---KWE--------KKVR---------------------------
---------------------EELVLG--------------LAWSTWFLAKSGPISYLVL
GFSFPS------------------------------------------------------
----------------------------------------------------------LP
PVE-----------------------VTHRYFLRYFVLCLYFQVEVT---L--D-QETAN
PLLQ----------IS-----EDCKTVSYNDTSM--V--VS-M------------PEN--
EKIFH-SPCVV-----------ASQGFY---MGECY---WE-VE-V------GKKNRWYL
GVCLDSVN-R--K-EKL-------------------------------------------
---------------PKLNPANGYWVLGRW--N--------QYEHFVFSPN-R-----QI
---------------------------------LTLQVHPM---KIGIFLNYKYGQISFF
NVTNKSH--IYTFTGCNFNG-KILHPYFRPRSNDIQ---EPSYPLTIC-TK---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------PN-SE--VKV
--------L-GPE-YTVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRNHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKF-VKDYIAYGSV-ILQLHSIIPSDEGTYGCR--FL
-S-N--NFSGEA-LWK------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--S----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRCQEKLKK--------EAEK-REG---KLTAELE-------------
------------------KLQKEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDGKSVSSR---RAPP--GP-A------------PSD--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGIFLDCEAGQLSFF
NVSDGSH--IFTFHDTF--S-SALCAYFRPRAHDGG---ERPDPLTIC-PLR-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPT----------
-----DPAPD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------ACLLLNFHVS
VFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVKGYENG-GI-H---L--ECRSTGWYPQPQIKWSDAKG-ENIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGG-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FTSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETERERELKEMGYAATK-------------
----------------QEIS---------LREKLQE-E---LKWR---KIRYMA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCENFT---SGRHY---WE-VE-V------GDRKEWHI
GLCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NAMDGSH--IYTFPHTSF-S-EPVYPVFRILTLEPT-------ALTIC-PTP-KEVERSP
-N--P--D-----------------------LVLD--------HSLETPVT------PAL
ANESGEPQAEVTSL---LLPANAGA-EGLPFH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESA------AALHFS-----RPASLLL-----
LLLLSLCA-------------------------------------------LVSAQ-VTV
--------V-GPT-DPILGMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGREITEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--I-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GVVPALK-------
--------------------------EV-SMPDADSLFMVTTAVIIR-----D--KSVR-
NMFC-SINNTL-LSQ-KKESV-------IFIP-ESFMP-------SVSPCAVALPI----
------------------------------------------------------------
------------------------------------------------------------
----V-------------------------------------VVILMIL-----FAV--C
M-----YWINKLQKEKKI-LSG--------EKEFERETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEE----EL----------------------------------------
-QV---KEKLQEELRW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--RPFR-HLGES-M------------PDN--
PERFNSQPCVL-----------GRESFA---SGKHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KSQYRAVSSPDR------I
---------------------------------IPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRLGCEDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYSDGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNTKG-QHIPAV--------
--------------------------KAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATK-------------
----------------QEIS---------LRGI--------QKWR---KIQ---------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------YMAPDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPW---KVGIFLDYETGDISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--G-----------------------LVPD--------HSLETPVA------LDL
ANESGEPQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPRHLFPTMSAETT-ELRWVSSSL-R---Q-VVN
LYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-AL-IHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIKWSDTKG-ENIPAV--------
--------------------------ETPVVADGVGLYAVAASVIMR-----G--SSGG-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATE-------------
----------------QEIS---------LREKLQE-E---LKWR---KIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHASF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-KEVESSP
-D--P--D-----------------------LVPD--------HSLETPVT------PGL
ANESGEPQAEVTSL---LLPAHPGA-EVSPSA--------T-TNQNHKPQARTEALY---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MGAAG---G---LAV--------APC------VA
LLLLQ-TV------------------------------------------ALSPER-FTV
--------T-GLT-RPVLAPLGGTLELSCQLSPPQDAQHM-EIRWFRNRY-T---Q-PVH
LYRDGEDLHGE----TIPKYVERTEL-LKEDIGEGKV-TLRIFNVTVDDDGPYRCV--FK
-N-G--EFYEEH-ITE------V--K-VT-------------------------------
------------------------------------------------------------
------------------------------------------------------------
NVTC-YLQNRL-TQQ-EESIN-------IVLS-GELFA-------WKCVWIGILSIITIL
MIV-FFMTSYVQQ-HFIHGFFS---GK---------------------------------
------FFHWLKVLVVFISP---MSTIIGIVFILNLK---------------QRVQVSDP
H---FELD--T--------------------LWI-EDISV-VMCV-MIV-FIFKLI-L--
F-----IYFQLE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLP
---V-------------------SLDSLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------LS-SE--VKV
--------L-GPE-YTILALVGEEVEFPCHLWPHLDAQQM-EIRWFRSHT-S---D-VVH
LYQEQQELPDR----QMQVFRNRTKL-VKDDIAYGSV-VLQLHSIVPSDKGIYGCR--FL
-S-D--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GALS-
NVSL-SIQNLL-LSQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------P----WKS-AFVAT-LAA-LPPLLLVLAALA--
L-----RFLQKQRRCQEKLKK--------QAEK-RQE---KLTAELE-------------
------------------KLQTEL----DWRRDEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSSR---GAPP--GP-A------------PRH--
PQRFSEQTCVL-----------SLERFS---AGRHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPGAGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDFEAGKLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAPDGG---EHPDPLTIC-PLP-VRGTCVP
EEN------DSDTWVQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT---G---VL----------LC------VV
LHFLH-MV------------------------------------------AQSSEK-FTV
--------T-GLQ-RPVLAPLGGNVELSCQLSPPQQAQHM-EIRWFRNRY-R---E-PVY
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLRIFKLTADDDGSYHCV--FK
-V-G--EFYEEH-ITE------I--K-VT-----ATSSVM-----------------YI-
------LMQPPNIK-GV-M---L--ECHSGGWFPQPHMEWRDSKG-NIIPA-T-------
------S-------------------KA-HSQDENKLFNMTMTLLIE-----A--SSHR-
SVTC-YLQNLL-THQ-EESIS-------IVLS-GELFS-------WKRVWIMILTTIGFM
MIA-FCMTYCVQQ-HLLYGSF---------------------------------------
---SKEKCHWLKSTMVFMFS---VIAVTGVMLILHLK---------------QRVPVSDQ
H---FELD--T--------------------LWL-EDISV-ILCV-LIV-FIIKLI-S--
F-----IYFRLEGDH--------------QGWSLPPY--------PSATPT---------
------------------------------A-----------------AICR--------
---LAV-------PEYS-----RGHLQL------------DS-----EDDLAGMDPFPFF
ITPCF-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----RQASLLL---LL
LLLLSLCA-------------------------------------------LVSAQ-VTV
--------V-GPT-NPILAMVGENTTLRCHLSPEENAEDM-EVRWFQSQF-S---P-AVF
VYKGGRERTEE----QKEEYRGRTTF-VSKD-SRGSV-ALVIHNVTEEDNGIYQCY--FQ
-E-G--RSCNEA-ILH------L--V-VA-----GLDSEP-----------------VI-
------EMRDHEDG-GI-Q---L--ECISGGWYPKPLTVWRDPYG-EVVPALK-------
--------------------------EV-STPDADSLFMVTTAVIIR-----D--KSVR-
NVSC-SINDIL-LGQ-KKERV-------IFIP-ESFMP-------SRSSCVVILPV----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------MIILMIP-----------
-----------------I-AIW--------QKELEQERKETALKELE-------------
------------------------------------------------KEHVE-------
------------------------------------------------------------
-----------KEKEL--------------------------------------------
----QIKGKR-GQVWW--------------------LMA---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSLHSC-----PLASLLF-----
FLVLSLLA-------------------------------------------LLSAQ-FTV
--------I-GPA-EPILAMVGENITLHCHLTPERNAEDM-EVRWFRWRF-S---P-AVL
VYRGHQERPEE----QMVPYQGRTTF-MSTDISKGRV-ALIIHNVTTYDNGIYYCY--FQ
-E-G--RSYDQA-TIR------L--R-VA-----SLGSEP-----------------LI-
------QMKTLEDG-SI-L---L--KCTSGGWYPEPRAVWRDPYD-EVVPALE-------
--------------------------EE-YTADREGLFRVTMTIIIR-----D--CCVR-
NMTC-SINNTL-LSQ-ETASV-------ILIP-EPFVR----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--A----------------L----WMV-ATAVI-LPIVMVILL---TSG--S
I-----CLVKKHHRKKSI-LS---------------AEKEAKYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ETARQLQEELQW--------------------RQTLLHAADVV---L--D-PDTAH
PELF----------LS-----ADQRSVRR--GPSR----QS-V------------SDN--
PERFDCRPCVL-----------GRDS FS---SG KHY---WE-VE-V------ENVMVWAI
GVCKDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RVAVFLDCEGGDISFY
NMRDRSH--IYTCPPVTF-T-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLFLYRTRPISQSLVRKP----ESSAQHY-LV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MGVQQQQ
---QQQPGV-RG----------QS-RWEQPRGDSW-----ALR---TSRESRFLP-----
-VEAGTEL---RCA---------------------------------------EEE-FQV
--------I-GPS-EPIVAVLGGDATLRCSVVPAMNVKNM-ELRWFRTTF-T---D-SVF
TYRNQREQKEE----QMAEYAGRTSL-VMDFLDHGEA-AVNIHEVRVSDNGMYNCF--FK
-M-G--SFFEET-NLE------L--K-VA-----GVGSAP-----------------QV-
------HVEGPEED-GV-R---V--VCRASGWFPKPQVQWRDVSG-KKILA-F-------
------S-------------------EA-HMQDADELFSVEATLVVR-----D--RSMG-
NVTC-SILNPV-LGQ-KKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFAVS-LTV-----MGLLLFGA--
V-----YFLHREHSEKLQVQQ--------EEKNLKLA-KEEDKITKEQA-QKVN------
------------DE-LQ----AELG-----QRKAAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFQAL-------------SVT---L--D-PGSAH
PSID----------IA-----PGKTSLTWKEP----------------------------
--GGSDTCSVL-----------GLEGVR---AGRCY---WE-VE-ITKGD-SSEWTEWTV
GVCREDVK-R--T-GW--------------------------------------------
---------------YKESLEKGFWVVG-W--G--------KSGCFTYVKSDT----VLP
---------------------------------LEQSQDG---RRVGVFLDYSEGDVSFY
DMTDGSH--IFSFPPASF-S-GTLFPYFSFLRGS-V-------SLTIC-SPE-SGSLGLP
APLH----N------------------------RP---------SVKETLRPSG-EGLSS
GADVGDVAPGVESP---LLPGTLRAA--IP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MR
SETALIT-------------------------------------------GCPAGQ-WQV
--------A-GPD-KPVQTLVGENTVFSCFLSPETNAETM-EVRFFKDQF-S---D-VVH
LYRNGEDQAYM----QMPAYRGRTVL-VKDFITNGHV-SLELRNITFSDAGLYGCS--FS
FH----TYHQDA-IWE------L--Q-VL-----ALASTP-----------------LI-
------SIMGYGDG-GI-Q---L--LCQSSVWLSQPIVKWKGPQG-HGLSSDS-------
---------------------------K-ITAGRHGPFDVESSFIVQ-----Q--N-SG-
SVAC-SIQPPD-QSQ-EIQSR-------IWIR-EIFFRP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WSL-ASILLGLLC---FVLSVGIVAV--
-----RTFFSKYQRK----YL--------AEL----------------------------
------------------------------------------EWR---KKHA--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------EAELKKHQKYAVEVT---L--D-PDTAH
PQLY----------VS-----D-LKSVIFKEA----P--QD-V------------SYT--
EKRFK-RKCVV-----------ASQG FQ---TG QHY---WE-VD-V------GHNESWCL
GVCQDNVH-R--W-EED-------------------------------------------
---------------LDLSPIRGYWVLRRR--E--------EHDYFTLDPH-R-----VT
---------------------------------VVPGIHPT---RVGVFLDCERRIISFF
SVNDQSL--IY-TMDYPLEG-T-LRPYILPQTYK-E---NELTPIFIP-SLS-QE-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MET-VSSS-----G-----SRLSSCFI-----T
LIFLQLPI-------------------------------------------RV-S-----
----------GDSGQVHLAPLGGTAKLLCPLSLWSVTTLT-EVRWLRSLPRG-RSQ-VVH
VFRDDKVREED----VVPEFKGRTAL-ERDT-QEGNV-TLEIRHVRLEDRGPYRCQ--VR
-I-A--NLSREG-TVI------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-Q---L--VCRSVGWFPRPWAEWRDPQG-RVLPSEP-------
--------------------------QA-PSLDHAGLFETAVSSKVR-----D--STVG-
SVSC-TIRNEA-LGQ-EKTAA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----P---------------------AA-VALAVV-LPV-----LGLLIMAG--
I-----GLIWKQRRSKEKLLYE--QVMEVE-TLLSDHANEK-GR----------------
---------------------------------LH-------------KSL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRRVQLGDR----R--QP-V------------PDT--
PQRFDFVVSVL-----------GSEAFV---EGCHY---WE-VF-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RAAEYEALTSPQT------P
---------------------------------FRLKEAPR---CVGIFLDYEAGVISFY
NATDRSH--IFTFTHAF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QKSEEPV
VPKP---------------------------------------------------DGKG-
-HANGDVALKVDAS---L--------------------RPWSPDLGPALQGLKVPFF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAIVGENTTLRCHLSSEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGRRERTEE----QMEEYRGRITF-VSKDISRGSV-ALVIHNVTTQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPALK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEI-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------ARW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLHYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDCPRYSLSGV---AASFLFVL
LTIKHPDDFRVVGPNLP-ILAKVGEDALLTCQLLPKRTTAHMEVRWYRSDPDMPV-IMYR
DGAEVTGLPMEGYGGRAEWMEDS-TEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSV
LLQVAALGSSPNIHVE---------GL---GE---------------------------G
EVQLVCTSRGWF----------PEPE---VH---WEGIWGEKL-----------------
-MSFSENHVPGED--------------------------------G------------LF
YVEDTLMVRNDS----------------------------------VETISCFIYS----
HGLRETQE------------------------------ATI--ALSER-LQTELAS-VSV
--------I-GHS-QPSPVQVGENIELTCHLSPQTDAQNL-EVRWLRSRY-Y---P-AVH
VYANGTHVAGE----QMVEYKGRTSL-VTDAIHEGKL-TLQIHNARTSDEGQYRCL--FG
-K---DGVYQEA-RVD------V--Q-VM-----AVGSTP-----------------RI-
------TREVLKDG-GM-Q---L--RCTSDGWFPRPHVQWRDRDG-KTMPSFS-------
--------------------------EA-FQQGSQELFQVETLLLVT-----N--GSMV-
NVTC-SISLPL--GQ-EKTAR-------FPLS-DSKI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMTLPVVVL-PLAMA-------------
I-----DLIKVKRWRRTNEQT--------H-SSNQENNK---------------------
---------------------------------N-DE-N--HRRR---L-----------
--PS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-E----
--------------RL-----R--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MELVTSL-ICP-----SP--------RLLGSA--PA
-PLSLYSF-------------------------------------------APAAQ-FAV
--------I-SPA-KPILAQVGEDTELPCHLYPKMSAEHM-EVRWS-----S---D-IMH
LYKNREDQLQE----QMEEYQERTEL-LRDNIAKGSV-AVRIHCVRESDKGHYYCS--FK
-V-L--HTHVNL-TCK------F-----L-----PPQLCTSI-----------LTSK---
-------RWGVEDR-GV--------WLECTGWHPKSQ-EWGRDSR-EEAVP-S-------
-----LSP--------------HPRMGS-DLSIVNIIYC-------R-----C--FEDG-
ESKCLTFPKCL-CS--VVEP----L---GVIG-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------H
F---FPRV--R----------------------II-VLSVT-LPA-----LGLLVTWG--
L-----CLLWKRSRKKEFRKK--------EELKRMKR-----------------------
----------------KKHNK---------NGKHQA--E--LRWS---QAQL--------
------------------------HAL---------------------------------
------------------------------------------------------------
--------------------------------------------DIT---L--D-PATAH
PNLA----------LL-----ENWKCVTWRET----P--KS-L------------PEN--
PEGFDFYPRVL-----------GREGFT---SGRHY---WE-VE-V------GGREAWGL
GVCRENVK-K--K-AE--------------------------------------------
---------------VSESPKNGFWVVE-G--F--------RSRYWALTSP-Q-----TP
---------------------------------LSLNVFPR---RVGVYLDYEAGNISFY
SRTDGSH--IYTFAHTTF-S-GTLWPFLSLWFSDPT-------PLTIC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------M--M-GFP-----DSS-----MPRCLL----FL
-QLLQMAT-------------------------------------------LGSAQ-FAV
--------I-GPA-EPILALEGGDAELSCHLNPKMSAEMM-EVRWYRAKF-F---P-AVY
VYRAGQDTDKE----QMEEYRGRTTL-VRDAIANGSV-ALRIHNIRASDEGRYHCF--FQ
-R-D--AVSEET-ILE------L--R-VA-----GLPSGQSLSM----------------
-----------FVS-GL-DSWDA--QGLGAKVCRTPTLTPTG----LSFLT-SGPGCAPL
WWGLVK----------GS--SSPSQPSS-P-HK---------------------------
NIGC-CINALL-----STSF----S---VGST-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPRA--Y----------------P----LMV-TLAVT-LPA-----LGLLITGG--
L-----YLIWKLDSDKGQETR--------TEF----------------------------
------------------SLS----------GKFQA--E--LRWR---RALF--------
------------------------PAD---------------------------------
------------------------------------------------------------
--------------------------------------------DIT---L--D-PDTAQ
PELI----------LS-----KDLKCVTRGDT----W--QD-L------------PNI--
PERFDPKAQVL-----------GREGFT---SGRHW---WE-VE-V------GDRTCWDV
GVCSENVT-R--K-GM--------------------------------------------
---------------IPVSPKNGFWAIG-S--D--------GSKYWALTSA-L-----TY
---------------------------------LSVKIPPH---RVVVYLNHEAGVISFY
SGTDGSH--IYTFFHTTF-S-GTLHPFFFLWSHDPG-------PLTIC-PVP-SG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EVRWSRSRF-S---A-VVH
VYRDGQDQFGE----QMPEYRGRTEL-LKHNITDRKV-SLRIRDVRPSDEGQYKCL--FQ
-S-G--VFYEEA-SLE------L--Q-VA-----GLGSVP-----------------DI-
------AVEGHQDR-RI-R---L--VCRSSGWFPKPQAEWRDQQG-QRLPS-A-------
------S-------------------ES-SSQEAGGLFGTEIAIVLT-----E--RSSR-
KVSC-RVRNPR-LNQ-ERES----A---VSIA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
F---FSRD--K----------------P----WIV-AMGVT-LTL-----LAGLIPLG--
S-----YCFARHYEAKDEVEA--------ELGWKRITPLLMDC-----------KW----
-----HIG--KNIRKLKEVHSKLP---SSFP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------S--PRIGW-RC-----A-----QLC---------AVDVT---L--D-PDTAH
PKLV----------LS-----EDGKSVRHGDT----R--QD-L------------PDT--
PERFDPCVCVL-----------GAEGFV---GGRHY---WE-VG-V--GD----KPAWDL
GVCRESAS-R--K-EE--------------------------------------------
---------------IAYSPENGYWVVW-L--R--------DEEYKARTSP-P-----TL
---------------------------------LSVSARPS---RVGVFLDYEAGEVSFY
NVTDRSR--LFTFTD-TF-S-GTLRPFFCPGLNAGG---TNAAPLTIC-LAP-AQAGEDP
SPAS----E------------------------GK--------------DR---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDCCRG-------------SLLSCLTSL----
LLFFQLPA---GGS---------------------------------------AEE-FVV
--------I-GPP-GPIVAVLGGNVTLPCHVSPAVDVENM-ELRWFRSKF-S---E-VVF
IYENQQEQKEE----QLAQYTGRTSL-VKDFLSQGEA-TVRIHKVQASDNGLYTCL--FR
-K-G--SFYEEA-SLE------L--K-VA-----GVGSVP-----------------QV-
------HITGPEED-GV-R---V--VCTASGWFPKPQIQWRAANG-EKFLT-F-------
------S-------------------ET-HAQDTEGLFSVESALVVR-----D--SSSG-
NMTC-SVLNPV-LDQ-KKAMA-------VFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFIVS-LVV-----LMLSLLGA--
A-----YYIKTEHTVKRQEMQ--------EWERLHRD-KEEARRTKEEA-LKAR------
------------GK-AA----QE--------PRVCP--F--SGWR---KALLYA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VSVT---L--D-PASAD
PHLA----------VS-----GGQTSVTLENTTE--D-----------------------
--P-EGPCSIL-----------GQEAIT---SGRCY---WE-VE-IRNGN-RS---EWSL
GVCRGDVD-R--K-YW--------------------------------------------
---------------YREWPVEGFWVLR-W--C--------RGKFCAFLLPES------Q
---------------------------------EIGDEVPH---RVGVFLDLKEGDVSFY
NMTDGSH--LFSFPLTSS-T-GTLFPYFMIQSGD-V-------SLTIC-SVV-GVPTETP
VPLN----N------------------------PP--------SSLEEPVSLSG-DGFSS
GSAVDGALPGADSP---LLSYGPEVS--PG------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MFKPK-QGC---SWP--------QTY------SG
------FL------------------------------------------FSSTEK-LVV
--------T-TST-GHLVAVLGGQAMLSCQLLPPQSAEHM-EVRWFRGEH-S---K-PIH
LYGGSHELNEE----TAPEYKNRTEI-VKEGIGKGKV-TLRIHNISISDDGSYQCL--FS
-D-N--DFSDVA-SMN------L--S-VA-----AHGLGT-----------------QI-
------HVQHPHTE-GL-M---V--ECNSRGWFPQPQMEWRDSKG-EVVPH-S-------
------S-------------------KS-YSRDGAGLFHMKMTLL-T-----S--QSYN-
NITC-CIYNTL-TGE-GKRTN-------IILA-RKNFN-------RIILWLNNIDKQM-W
IQN-SIVVFWSVLTFSVLGHMSRC---------------------------------CRI
SPCSRMLNSMTVQLLC--FT---ICPIILIAVFLPFRIRGLN-FKT------QKFILLDT
L---VTIK-----------------------SF---------LFF-LFL-FVCFLKIL--
L-----LCIYF-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GL---CFY--------GHC------IV
MCLLQ-MI------------------------------------------TASSEP-FIV
--------N-GSE-GPVLASLGGNLELSCQLSPPQQAQHM-EIRWFRNLY-T---E-PVH
LYRDGKDMFGE----IISKYVERTEL-LKDGIGEGKV-TLRIFNVTVDDDGSYHCV--FK
-D-G--DFYEEH-ITE------V--K-VT-----AINLRV-----------------QI-
------NVHPPNTK-GV-I---V--ECHSGGWFPRPLMQWRDRRG-EVIPA-A-------
------S-------------------KS-HSQGRDKLFNMKISLLIR-----E--SFFP-
KVIC-CLQNPL-TGQ-EERTS-------VILS-DAFFS-------WNRIWKMILGIILSM
MVV-SILVFSCLL-HHEHKVFR--------------------------------------
---CTWDAPWIIGLLIITSS---VVTVVLVMVYLHMK---------------QRVPVSDV
H---FELD--T--------------------LWV-EDISV-ILCS-LMV-PATMLV-S--
Y-----TYFRLKDWC--------------QHNHAQRV--------FTSN-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLP---------ACL-----LV
LTFFQLSR------------------------------------------PDS-AP-FDV
--------I-GPA-EPVLAALGDDAELPCRLSPSVSAERM-ELRWFRGKV-A---A-AVL
VRRDGREREAE----QTAEYRGRATL-LYGDIAAGRV-AVRIHRVRASDDGEYRCL--FR
-Q-DG--RYGEA-SVH------L--K-VA-----ALGSDP-----------------QI-
------HMEVQESG-EI-R---L--ECTSVGWYPEPQVQWRTSEG-EWFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSMK-
NISC-HFQNLL-LGQ-EKEVE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-LMV-----LGLLTIGS--
I-----FGTWRLYRERARQRK--------DEFSSK-------------------------
-------------------------------EKLLE-EL---KQK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHF---WE-VE-V------GDRADWAV
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPQNGFWAVELY-----------GNGYWALTPQ-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDVSFY
NMANGAH--IYTFSNASF-S-GPLRPFFCLWSCG-------KKPLTIC-PPT-DGPERVT
VVVD----A------------------------KD--------FAKEIPLS---PMGEDS
ASGDTDT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDLSCCP-----V--------LCRLTPL----
LLLIQLLT---GGS---------------------------------------LEE-FSV
--------L-GPS-DPIVAVLGGDAVLSCRVFPAMNAEDM-ELRWFRSKF-S---E-AVF
IYQNRQEQKEE----QLAGYAGRASL-VRDFLSQGEA-AVRIGQVQVSDNGLYTCF--FR
-K-G--VFYEEA-SLE------L--K-VA-----GVGSAP-----------------EV-
------RITGPEED-GI-R---V--LCTASGWFPKPQVQWRDGSG-EKFLA-F-------
------S-------------------EA-HTQDAEGLFSVEAALVVR-----D--RSVG-
NVTC-SVLNPV-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFLVS-LTV-----LMLLVLGA--
G-----CYIRREHSIKLREME--------EKRHLWQA-KEEARQTKEKA-LQDR------
------------AE-LQ----AQLN-----WRKDVY--L--AGWK---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RT------EKFQPR-------------PVT---L--D-PGSAA
SSLV----------VT-----HEKTSVTRKN-TG--V-----------------------
--NPGDMDSVL-----------GFEDIS---SGRWY---WE-VE-IKDGD-GC---EWAL
GVCRKDVK-R--E-GW--------------------------------------------
---------------CRESPEKGFWLVG-K--F--------SDKYFVYTAQYT------E
---------------------------------LSLHQVLH---RVGVFLDHEEGDVSFY
NMTDGSH--IFSFTGVSF-S-GALCPYFKLRAGD-V-------SLTIC-SKV-GGSEGLP
VPLN----D------------------------S----------CLEEPVSLPG-EEISS
GSGADA-PPGAESP---LLPCNPEAV--SP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT---G---VL----------LC------VV
MHFLQ-VV------------------------------------------AQSWEK-FTV
--------T-GLQ-RPVLTPLGGNVELSCQLSPPQQAQHM-EIRWFRNRY-T---E-PVY
LYRNGKDLHGE----TISKYVERTEL-LKDDIGRGKV-TLRIFKLTADDDGSYHCV--FK
-V-G--EFYEEH-ITE------V--K-VT-----ATSSDM-----------------HI-
------LMKPPNSK-GV-M---L--ECHSGGWFPQPHMEWRDNKG-NIIPA-T-------
------S-------------------KA-HSQDENKLFNMTMTLLIE-----A--SSHR-
SVTC-YFQNRL-THQ-EESIS-------IVLS-GELFS-------WKSVWIMILTTIGFM
VIP-FCMTYCVQQ-HLIYGSF---------------------------------------
---SEGN-YWLKSTMVLTFS---VIAVTGVMLIMHLL---------------RRVPVSDQ
N---FELD--T--------------------LWL-EDISV-ILCV-MIV-FIIKLI-S--
F-----IYFRLEGKY--------------DGNGGNSE--------N--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SDP----------TCLLLDFFVC
LVLIQ-------------------------------------------LLTPCSAH-FAV
--------H-GPA-GPILAMVGKDADLPCHLSPTMSAETL-ELRWVRSSL-R---Q-VVN
VYANGKEVEDK----QTPEYRGRTSI-LRDDITAGKA-TLRIHNVTASDSGNYLCY--FQ
-D-G--NFYEKA-MVE------L--K-VA-----ALGTDL-----------------HM-
------EMKGYKDG-GI-Q---L--QCRSTGWYPQPQVQWRDAKG-EIIPTV--------
--------------------------VAPVVADRVGLYAVAASVIMR-----E--SSGE-
EASC-TIRNSL-LQQ-EKTAR-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------R----WIA-ALAGT-LPV-----VLLLLTGT--
G-----YFLWRQQEEKKTL---------FKEKEREQKMSELAQITTE-------------
----------------QEKS---------TREKLKD-E---LKWR---KIQYMA------
----------------------FGK-----------------------------------
------------------------------------------------------------
--------KSP--------------------AYDEWKAALFQAADVI---L--D-PDTAN
PILL----------LS-----EDLRSLQLAEE----E--QD-L------------PDI--
PERFNWRYCVL-----------GRENFT---SGRHY---WE-VE-V------GDRKEWHI
GVCRRDVE-R---KGW--------------------------------------------
---------------VKMIPENGYWTMGRS--D--------GNNYRALTEP-R-----TK
---------------------------------LALSGLPE---KVGVFLDYETGEVSFY
NAIDGSH--IYTFPHTSF-S-GPLCPVFRILTLEPT-------TLTIC-PAS-KVVES--
--SHV--PD----------------------LVPD--------LSLKTPVT------PSL
ANETTEPQGEVMCP---LLPAQSGA-EGLPLH--------S-SHHNHLMDAETELLL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------EDRAPAW-AFP-----PE-------GVCI-------
-SVFFPLP-------------------------------------------VSTEK-FMV
--------L-GPA-EPLVAVLGRKVVLSCHTTPARSAENM-QLRWFRSKF-S---E-AVL
IYEDGGEQPQE----LMAQYAGRTSL-VTELLGQGQA-AVLIRDVQASDDGLYSCS--FR
-E-G--EFYEEA-SLE------L--K-VA-----ETVAKET----------------HV-
------ARTGCGVG-GG-R---L--HCSPGGWLLRQQRTFHETAG-AQ------------
-------------------GPGDSAPGD-GSSCWFSLFQ----VNCR-----P--SSNG-
GGACTWLVN--------SHL----S---YFPT-N--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---SEKD--S----------------A----AHL-PRGFP-QPL-----LGTLPVGR--
LPWGAGQVLWPRSHQ---------------------------------------------
---------------------------------VCS--L--SAWR---KAQLYA----VW
G-------------------AVPGALEEKL---SLCE-----------------------
-------------------FL---------------------------------------
-----EEN---------LA------FRMAVWF-----GTWESNLDTE---SGPF-GPGQS
PDLV----------LSVKLSREGGSMVARLEG----D--CE-D------------SGG--
SEAFVTARCQQ------------DLSLR---GGGLL---W-------------GRNEWFL
GVCREDVK-R--T-GW--------------------------------------------
---------------YTESPEKGFWVVG-Q--F--------EAGFCPCTKD-P-----TP
---------------------------------LPLRQLPR---RVGVFLDYSEGDVSFY
NMTDGSH--IFSFPRASF-S-GTLFPYFRLKS-GVG-------SLTIC-PMA-GAPEGLP
VP----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------------MVGFLDF----------------SLLRDF--FS
LLLLQVSM---WGS----------------------------------------DS-FLV
--------I-SPS-EPIVAMLGMDTVLPCHVSPAMSAENM-ELRWFRSEF-S---E-AVY
VYQDGMEQAGE----QLVDFKGRAEL-VKDYITEGRV-SVRIYSLRISDSGIYKCF--FK
-K-G--SEFQEA-TLE------L--K-VI-----GLGSGP-----------------HV-
------FMVGPEGT-GI-R---L--TCTGKRWFPQPEVQWKDAMG-EKIPS-L-------
------S-------------------EV-ETQDDDGLFQIEASLIVR-----D--SSKR-
EVSC-SMKNPF-FGQ-EQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WMT-AFAVT-FII-----LGIFLGAV--
V-----FLAWKERQEKKRTQE--------A----QAE-KEKESKD---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------KDW-RK------AKLYAV-------------AVT---L--D-PDTAH
HNLI----------LS-----ENRKQVSL MGNAP--Q-NGD-A------------SVHQG
QGESETIFSVL-----------GQNCFT---TG RHY---WE-IE-VNIGTEVGLEPRWAV
GVCSDTAE-R--D-GW--------------------------------------------
---------------FVESPEKNFWVIA-Y--N--------KGVLF---THL------ES
---------------------------------LSLRQHPQ---RIGVFLDFEDKDVSFY
NMVDGSH--IYSFTGITF-C-GTSRPYFSLQGAG-T-------YVTIC-SAS-DDTENYP
ESSP----KT---HLK--------------------------------------------
-SR-DVGVAQEANP---LLPP---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPN-KVVQALVGEDAVFSCFLSPKTNAEAM-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPRYQGRTEL-VKDSVAEGRL-SLRLENITALDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCQSSGWFPRPIAKWKGPQG-QDLSADS-------
---------------------------R-TNTNMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WHL-ATKVLGVLC---CGLFLGIVGL--
-----KIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKYAVEVT---L--D-PATAH
SQLC----------VS-----D-LKTVTHRKA----P--QD-M------------PRS--
EKRFI-RKSVV-----------ASQGFQ---AGKHY---WE-VD-V------GHNQRWYV
GVCRDDVN-R--R-KKN-------------------------------------------
---------------VTLSPNHGFWVLGLN--A--------ENLYFTSNPH-F-----IS
---------------------------------LFPRTPPT---QIGVFLDYECGTVSFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSHN-E---QNGTPIVIC-PVT-QESERMV
SWQS---------------------------------------------------ASAIP
ETSNSEFSSQATTP---FLPGSDA------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYTLSGA---LASFFFIL
LTMKQSDDFKVISPAYL-ILTKVGEDALLTCQLLPKRTAMHMEVRWYRLEPSTPV-FAYK
DGAEVTEMQMEEYRGRVEWLKD-DIAEGNVALKIYNNQPSDHGQYWCRFQEGTYCAETSL
QLEVAGLGSSPEIHME---------GT---VE---------------------------S
GVQLVCTAEGWF----------PEPQ---VY---WKNTRGEKI-----------------
-LSLSEHYIQDKD--------------------------------G------------LF
YVESTLVVRDAF----------------------------------TETMSYVIYS----
PILSEEKR------------------------------SAI--SIPVK-LQTELAS-LQV
--------I-GPS-QPILVRVGEDTQLTCYLSPKANAQSM-EVRWVRAHR-Y---P-AVY
LHMDGEHVARD----QMEEYRGRTVL-VSDAIDEGRL-TLQIHNVRTSDDGQYWCL--FE
-K---DGVYQET-SLD------L--K-VA-----GLGSSP-----------------LI-
------TMKRWKDG-EM-Q---L--VCSSDGWFPQPHVQWRDMEG-KTIPLFS-------
--------------------------EN-LTQDSHGLFHVETSLLVR-----N--SSIV-
NVTC-SISNSL-LGQ-EKTTT-------FSLS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FLV
--------I-GPS-EPIVAMLGADTVLPCRVSPAMSVENM-ELRWFRSQF-S---E-AVY
VYQDGMEQTGE----QLVDFKGRAEL-VKDYIAEGRV-AVRIHSLRISDNGMYKCF--FK
-K-G--SDYEEA-ILE------L--K-VI-----GLGSAP-----------------HI-
------FMVGPEDE-GI-R---L--TCTGKGWFPQPEVQWKDAKG-EKLPS-L-------
------S-------------------ED-ETQDDDGLFQIEASLIVR-----D--SSKR-
EVFC-SMKNPF-FGQ-EQEAT-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKV-AFAVT-FLI-----LGIFVGAV--
M-----FLAWKEQQEKKRVRE--------A----MEE-KEKESKAKDL--VGSV------
------------NLQVFFSMAVHMV-----RRKEL---YQ-QDWR---KAKLY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------EQFEEV-------------AVT---L--D-PDTAH
PNLI----------LS-----ESGKRVSSIENVP--Q-NWE-------------------
---SETIFSVL-----------GQNSFT---TGRHY---WE-VE-VKTGTEVGPGTRWAL
GVCSDTVK-R--E-GW--------------------------------------------
---------------FVESTEKNFWVII-Y--K--------DGEIRTLTSRP------QT
---------------------------------LSLRQHSH---RIGVFLDWEAGDVSFY
NMVDGSH--IYSFAEVTF-C-GILHPYFSLQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------S-SPG---KLT---AE--L---------
-----------------GKMQSEL----DWRRAEGQ-----AEWR---PAQQYA----VN
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-SASAH
PSLE----------VS-----QDDRSVSSRW--AALF--PA-V------------PGD--
PQRFTEQMCVL-----------SHQCFR---TGLHY---WE-VD-M------CQRSRWFL
GACLEAVA-R--A-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------GCEYFVLEPH-R------R
--------------------------------ALSLHVLPQ---RVGIFMDCEAGKLAFF
NVSDGSH--IFTFTDTF--S-GPLCAYFRPRAPDGS---TRPDPLTIC-PLP-LRGTPVP
EEE------DGDTWAQ----------------------------P---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVA
FFLVQ-------------------------------------------LHTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITVGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYENG-GI-H---L--ECRSTGWYPQPQIQWSDAKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNAV-LGL-EKTAS-------VSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSDTDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVCSPVF----------------SLLRDL--FL
ILLFQMSM---RGS----------------------------------------DS-FSV
--------T-GPS-EPIVAMLGADTVLPCRVYPAMNVENM-EIRWFRNQF-S---E-AVF
VYQNGMEQVGE----QLVDFKGRAEL-VKDYITEGRV-AVRIHSLRVSDNGMYKCF--FK
-K-G--TDFEEA-VLE------L--K-VI-----GIGSGP-----------------RV-
------FLVGPEDG-GI-R---L--KCTGKGWFPQPEVQWEDVKG-KKIPS-V-------
------S-------------------ED-ETQDDDGLFQIEASLIVR-----D--SSTT-
QMSC-SMKNPF-FGQ-EQAET-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRP--S----------------P----WKA-AFAVT-LVI-----LGVSAGAI--
V-----YLAWKERQGKKKLSK--------V----EEE-KKKESTSKES--FK--------
---------------------RELA-----RRKEL---YQ-QDWR---KAELY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------EQFKAA-------------AFT---L--D-PKTAH
PNLV----------LS-----ENKQHISLKNNVS--Q-NGD-A------------STHED
QAVSEAIFSVL-----------GDKSFTQGDTERQY---WE-VE-VNTRTEAGSTTRCAL
GICSETVK-R--E-GW--------------------------------------------
---------------FVESPDKNFWVLV-H--E--------EGKVVFPNSQK------NS
---------------------------------PSLRQQPR---RIGVFLDWEVGNLSFY
NMADGSH--IYSFTGVTF-C-GTLFPYFSLRGTG-A-------SLTIC-STS-DHPEHCP
DSSP----KTSLTHLS--------------------------------------------
-S----SVPQEANS---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPT------TSLRSC-----PIASLLF-----
FLVLSLFV-------------------------------------------LVSAQ-FTV
--------I-GPA-EPILAMVGENTTLHCHLSPERNAEEM-EVRWFRWRF-F---P-AVL
VYRGHQERPEE----QMVAYRGRTTF-MRTDISKGRV-ALIIHNVTAYDNGIYCCY--FQ
-E-G--RSYDQA-TMK------L--M-VA-----SLGSEP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYD-EVVPALE-------
--------------------------EE-YTADREGLFTVTMTIIIR-----D--CSVR-
NMTC-SVNNTL-LSQ-EVESV-------ILIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AVAVT-LPVVMLILL---TSG--S
I-----CLVKKHRRKKSI-LS---------------AEKEAEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----EAARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVIR--GSSR----QS-V------------PDN--
PERFDCRPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RIAVFLDCEGGDISFY
NMRDRSH--IYTCPPVTF-T-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLFLYKTRPISQSLVRKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GL---CFY--------GHC------IV
MFLLQ-MV------------------------------------------TASSEP-FIV
--------N-GLE-GPVLASLGGNLELSCQLSPPQQAQHM-EIRWFRNLY-T---E-PVH
LYRDGKDMFGE----IISKYVERTEL-LKDGIGEGKV-TLRIFNVTVDDDGSYHCV--FK
-D-G--DFYEEH-ITE------V--K-IT-----AINLQV-----------------QI-
------HVHPPNTK-GV-I---V--ECHSGGWFPRPLMQWRDRRG-EVIPA-A-------
------S-------------------KS-HSQGRDKLFNMKMSLLIN-----E--SFFQ-
KVIC-CLQNPL-TGQ-EERTS-------VILS-DAFFS-------WNRIWTMILSIILAK
MVV-SIFVFSCLL-HYEHKVCR--------------------------------------
---CKCDAPWIKGLLIIISS---VVTVVLVLVYLRKK---------------QRVPDSDV
H---FELD--T--------------------LWV-EDISV-ILCS-LMA-PATMLV-S--
Y-----TYFRLEDWC--------------QHNHAQRV--------FTSN-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKRR-RFSG--SKSST-G---NISLLGYT--LV
FMSLLVHK-------------------------------------------LDSAH-FSV
--------I-GPD-QPLVATVGDEVLLACRLSPRMSAQNM-EVRWYRGQF-S---S-VVH
LYREGKDQYVE----QMSEYRQRTEF-QAGDIADGSV-ALRIRNIRLSDAGWYTCF--FR
-S-E--VSYQEA-AME------L--R-VA-----VSGTSP-----------------LI-
------SIEAYQDG-GV-R---L--VCRSGGWYPEPQSLWKGLQG-QPLPS-L-------
------P-------------------AK-CIQDENSLFQTESVLIVT-----E--KSNQ-
NLTC-AVRNSV-LNQ-EGVS----R---VYLA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
F---FPKT--S----------------Y----VTV-IRLTLNLLV-----LAFFIPCA--
I-----YYLWKQSKDTDKLRS--------QLKNLE-------------------------
-----------ENQRFQVEK----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EKEHY-L-------------ASFLLRKARRFSANVT---L--D-PTTAH
PELC----------VS-----PDQKSVKCANA----A--EE-Q------------PNN--
PDLVDSYRCVL-----------GAQKFD---SGRHY---WE-VK-L--EK----KTVWHL
GVCADSDD-R--E-QY--------------------------------------------
---------------KSIEPENGYWAVR-L--W--------NGEYKALSTP-R-----TT
---------------------------------ITLENKPE---RVGVFLDYEGEEVSFF
SLPNGSH--IYTFYRCVFSR-RSLRPFFSPGIHG-S---KEDVPLIIC-PIP-DW-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVKPE--FS---HFF--------GFC------VY
FLFLQ--V------------------------------------------MASSEK-LRV
--------T-TPT-RHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGH-S---Q-PVY
LYRGGHKMSEE----AAPEYANRTEF-VKEAIGEGKV-SLRIHNINILDDGPYQCS--FN
-A-S--GFIDVA-IMN------L--N-VT-----AVGLET-----------------EI-
------HVQAPDAD-GV-M---V--ECNSGGWFPRPQMEWRDSKG-ATLLH-S-------
------L-------------------KS-YSQDEARFFYMKMTLLLT-----N--MSHG-
SIIC-CIFNPV-TGE-EKQTS-------IILA-NELFN-------RDRIWMESLASI-VW
I-MLSVYILYIICFYWRTGCAS-----------------------------------GCL
SKCFCVVTSWPVQIVH--LL---FCTGTFFAIYLPHR---------------SRVSLSDP
Q---FPLY--N--------------------NWI-TELLF-VILF-LTI-CFALPIIL--
------LFIQFQFTSLTK--W--------EKNKDGIM--------DQ-PRL---------
------------------------------G-----------------KA----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------IKMA------SFL----------AFLLLNFHVC
LLLLQ-------------------------------------------LLMPHSAQ-FSV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL-R---R-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-TLRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-ENIPTV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------S----WIT-ALAGT-LPV-----LLLLLGGA--
C-----YFLWQQQEEKKTL---------FIKKKREQELREMAWSTVK-------------
----------------QEQS---------TRVKLLE-E---LRWR---SI---Q------
----------------------YMV-----------------------------------
------------------------------------------------------------
-----GGERHS--------------------AYNEWKMALFKPADVI---L--D-PKTAN
PILL----------VS-----EAQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LKLPKPPR---KVGVFLDYEIGDISFY
NAVDGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PVP-K----EE
SS--S--NS-----------------------------------------D------RVL
II-------------------P--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------CGAQ-FAV
--------I-GAP-EAIVAMVGEDAKLPCHLSPKMSSDSM-ELRWVKSRL-R---Q-VVD
PYPGGREAEAK----QANEFRGRMVI-LRDSVAERKV-ALRISNVRVSDSGHYLCY--FQ
-D-D--NFYEKA-MVE------L--K-VA-----ALGSDL-----------------HI-
------EMEGHEGG-GT-Q---V--QCTSAGWFPQPHVQWKDPRG-DALLAL--------
--------------------------AAPLSPDGAGLYAAERVCDGE-----R--RLWG-
GLSC-SIRNSL-LGQ-EKPAR-------VPIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRST--E----------------P----WAA-AFAAT-LPT-----LLQLLA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
-PLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-VPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
MYKGGRQRTEE----QMEEYQGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILR------L--M-VA-----GFGSKP-----------------LI-
------EIKIQEDG-SI-R---L--ECISGGWYPEPLTVWRDPYG-EVVPALK-------
--------------------------ED-STPDADGLFMVTTAVIIR-----D--RSMR-
NMSC-SINNTV-LGQ-KKESV-------IFIP-ESFMP-------STSPWVVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILAT--S----------------P----WTV-ALAVI-LAIFIIF-----MAV--S
I-----SCIKKLQREKKILLSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVTL--DPSR----ES-M------------REN--
PERFNSQLCVL-----------GWES FT---SG KHY---WE-VE-V------ENVLEWTV
GVCRDNVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RLGAFLDYEAGDVSFY
NMRDRSH--IYTCPHSGF-S-RPLKPFFRLGSYDSP-------I-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHHSPQDQFPGLTVM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTKT-RFQD-VFLPSC----FII---LVF--LQ
LLPTG----------------------------------------------IRSVN-FDV
--------I-GPD-DPILATVGKDTKLSCYLSHNVCATDM-ELRWYRNNF-S---S-AVC
VHE--KNVMYE----EQWKYRGRATF-MGDHISEGKA-AMRIHNVKEFDNGTYHCY--FL
-K-G--SYYREA-TLQ------L-----------RQGSKP-----------------TI-
------RVRDDKDE-GV-Q---A--ECISEDWDTQPEVEWRDLRE--TIPS-L-------
------T-------------------NL-SVSATTGYFVVTSRVVVN-----D--RTIE-
GFSC-SIVDPL-LN----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------ELVSGQ-WQV
--------T-GPG-KFVQALVGEDAVFSCSLFPETSAEAM-EVRFFRNQF-H---A-VVH
LYRDGEDWESK----QMPQYRGRTEF-VKDSIAGGHV-SLRLKNITPSDIGLYGCW--FS
SQ----IYDEEA-TWE------L--R-VA-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTAKWKGPQG-QDLSSDS-------
---------------------------R-ANADGHSLYDVEISIIVQ-----E--D-AG-
SILC-SVHLAE-RSH-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLLC---GALCAVVMGM--
-----IIVFFKSKGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QE-V------------PHS--
EKRFT-RKSVV-----------ASQG FR---AG KHY---WE-VD-V------GQNVGWYV
GVCRDDVD-R--G-KNN-------------------------------------------
---------------VTLSPSNGYWVLRLT--T--------EHLYFTFNPH-L-----IS
---------------------------------LPPSTPPT---RVGVFLDYEGGTISFF
NTNDQSL--IYTLLTCQFEG-L-LRPYIQHAMYD-K---ERGTPIFIC-PVS-RGSERED
PA----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAIVGENTTLRCHLSSEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGRRERTEE----QMEEYRGRITF-VSKDISRGSV-ALVIHNVTTQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPALK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLHYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LEMAVFP
---N---------------------------------SCLA---------GCL-----LI
FILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNVSAKGM-ELRWFREKV-S---P-AVF
VSREGQEQEGE----EMAEYRGRVSL-VEDHIAEGSV-AVRIQEVKASDDGEYRCF--FR
-Q-DE--NYEEA-IVH------L--K-VA-----ALGSDP-----------------HI-
------SMKVQESG-EI-Q---L--ECTSVGWYPEPQVQWRTHRG-EEFPS-M-------
------S-------------------ES-RNPDEEGLFTVRASVIIR-----D--SSMK-
NVSC-CIRNLL-LGQ-EKDVE-------VSIP-ASF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-LVV-----LGLLTIGS--
I-----FFTWRLYKERSRQRR--------NEFSSKGF--SHLFCSLPHT-----------
------------QARRSLSFP----------EKLLE-EL---KWK---RATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------ADLWS---V--S-D----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFA
---S---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILSIVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--IR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------YI-
------SMQVQENG-EI-R---L--ECTSVGWYPEPQVQWRSSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVTIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMA-----LGFLTIGS--
I-----FFSWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GHET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPH---RVGIFLDYESGDISFY
NMNDGSN--IYTFSNVSF-S-GPLRPFFCLWSSG-------KKPLTIC-PIA-EGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PMGEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------KISSPRGDISPPTLSCFLYLLSW
FLTNPIGQFTVVGPTQP-IVANFGEDAELLCQLDPKTDAEHMEIRWYRYNESNPL-HMYP
KRKDQEAELTPEFQERTMLVRN-SITSGMVALRIPRVKISDTGNYMCQFIS DKHFSEAVC
ELQVTSEGSTPTIHFE---------VL---GT---------------------------E
EIRLWCRSSGWY----------PEPQ---VQ---WRDSTGETV-----------------
-SNSEPVMSRDED--------------------------------G------------LY
DAKVAFTLRKNT----------------------------------TRTVTCSILS----
QA LKWKKE------------------------------SSV--LVTAS-LSPELAK-RGK
--------K-CPN -QPILVAIGEDAEVQCSLYPKTNAEHM-GIRWLRSDN-S---G-LLC
LYEEGTDQEAE----QMPEF-GRTIV-VRDAITEGRV-ALRIHQVRASDTGNYTCQ--FW
-S---DKYSVEA-MYE------L--H-AI-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SS----------PV--VCVSL----------------------PPV----
CVSQFSVC---SMS---------------------------------------TDE-FLV
--------I-GPS-DPIVAELGGDTILPCSLVPAMNAEDM-ELRWFRTKF-S---E-AVF
VYRNGREQHEE----QMPQYAVRTSL-VRDLLTHGKA-AVYILEVQASDNGSYTCF--FQ
-K-G--GRYAEA-ILE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGLEQD-GV-R---M--VCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGS-LTV-----LGLLLFGA--
G-----CFTRRELSAKLQERQ--------KQEKLHWD-KEEDQRAKEEA-LKAR------
------------DE-LQ----AEL------------------AWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------G-------------SSG---L--L-N----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAGFP
---N---------------------------------SCLI------------------T
LIFLWLPT------------------------------------------LDS-AH-FDV
--------I-GPP-EPILAIVGEDAELPCHLSPNVSAEDM-ELRWFRKKV-S---P-AVF
VHREGREQEGE----QMAEYRGRATL-VKTNVTAGRV-AVKIHGVKASDDGEYRCF--FR
-Q-ED--SFEEA-IVQ------L--K-VA-----ALGSDP-----------------HI-
------HMEVQESG-EI-W---L--QCTSVGWYPEPQVQWRTPKG-EKFPS-M-------
------S-------------------EA-RNPDEEGLFTVTASVVIR-----D--TSMK-
NVSC-CIQNLL-LGQ-EKEGE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVV-LMV-----LALLTIGS--
I-----FFTWRLYKERSRQRK--------DTFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDA----R--QK-L------------PEK--
PERFDSWPCVL-----------GREAFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMTDGSH--IYTFPNTSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIT-DGPEEVL
VVAN----G------------------------KD--------LSKEIPLS---PMGEDS
ASGDTDT---LHSK---LIPTQTSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MV-GFP-----ASS-----MPSCLVHL--LL
FLLLPKDM-------------------------------------------LGSAQ-FSV
--------I-GPD-KPILALVGGDAELSCHLNPKRSAEHM-EIKWLQSQS-L---N-IIH
LYDNGQDNNNV----QMDKYQGRTEL-VRNDIKEGRL-ALRISEVRATDDGQYLCI--FN
-E-G--PLSEET-TLE------L--Q-VA-----EMGSD-----------------PHI-
------RLVGHEDG-RI-R---L--ECSSAGWYPEPQVLWRDARE-ETF-P-S-------
-----LSK-------------------A-LSQTADGLFGVAASVIIQ-----E--GSMG-
TVSCSVQNSCL-SRE-KISA----F---ISIS-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPMA--L----------------S----LMV-ALGVT-IPL-----LGLLIAGG--
L-----YLIWKQNRDKALQFR--------PKPTTPYPHP--------AIQFLECNHNPSR
AKLLIELIWILGSL-HHSSDA----------SFLCS--L--AGWS---QAQL--------
------------------------HKG---------------------------------
------------------------------------------------------------
--------------------------------------------NII---L--D-PKNGL
SLYL----------ILYG---EFETRWKWEMR----K--GN-C------------QNT--
LRRFYRCACVL-----------GQENS----RQGDC---WE-VK-V------GDKMGWH-
GICRENVK-R--K-GW--------------------------------------------
---------------IFVLPEEGFWTVE-K--N--------EDGYWARTSP-W-----TR
---------------------------------LSLTKPPH---RVAVYLDYEAGVISFY
SGTDGSH--IYTFPRVTF-S-GTLRPFFWLSSTDPI-------PLTIF-SV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARA-HPGD-ATLPSV----LVS---FIF--LQ
LLTSG----------------------------------------------NGKSD-FLV
--------L-GPP-DPLLAIVGQDKELPCKLSLNISAEGM-ELRWYRDKP-S---S-VVH
VYKNGKDVYDE----QMTEYKGRTSF-NGSHVARGEA-SVKIHNITVFDNGTYHCV--FK
-E-Y--TSHSQA-TLW------L--K-VA-----GRGSSP-----------------RI-
------RVTDTQDK-GI-Q---A--ECSSAGWYPEPKVEWLDLKG-QPVPA-E-------
------S-------------------HF-SVSASTGLVAVLSIVTPQ-----D--MAVG-
GLTC-SISNPL-LPE-KVTE----T---YLL--A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---SRRP--L----------------S--TESGP-ALPLI-LTA-----LGLVSAAI--
A-----CAFGKCHKEEHKTNQ--------EEEEPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AR-D-------------------EAGLFHVSLS---L--D-PETAS
PKLM----------VS-----EDQKSVKRLLF----D--QD-V------------SSS--
SGRFDQDPCIL-----------AQER FE---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLV-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TC
---------------------------------LSPPEPLR---RVGILLDFEAGEISFY
NSTNGSL--IYVFSGFSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-RETKEDT
ESSG----G------------------------PG--------LPGDS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------KFL----------AFLLLNFHVC
ILLLQ-------------------------------------------LLMPHSAQ-FAV
--------I-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDDITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNTKG-ENIPAV--------
--------------------------EAPMVADGVGLYAVAAAVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGAA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQY--------
--------------------------T---------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYQTLTEP-R-----TN
---------------------------------LKLPESPR---KVGAFLDYETGDISFY
NAVNGSH--IHTFLDISF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KEEESSS
NS--D--SV----------------------MIIR--------CLPRDTSD------PGL
ARESGGASG---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSS-----G-----SRFSSCFI-----T
LVCLQLPV-------------------------------------------NL-SD-C--
--------A-GDAGRFYLAPLGGIAKLLCPLPLWSVTVLT-EVRWLRSSPWG-RSQ-AVH
VFRDGKNREED----VMPEYKGRTAL-VRDD-REGSV-TLEIRDVQLEDQGPYRCQ--VQ
-I-G--NLSREG-TVI------L--Q-IA-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------XXXXPGR
I---S-----S---------------------SA-LALAVI-LPV-----LGLLIVVG--
I-----CLIWKQRRSKERLLYE--QVMEVE-NLLADHAKEK-GR----------------
---------------------------------LH-------------NAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVTVT---L--D-PDTAH
PKLI----------LS-----EDCRCVKLGDR----R--QP-V------------PDN--
PQRFDFVVSVL-----------GSECFM---AGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRRS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPC---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHTF--S-GPLRPFFEPCLHDGG---KNMAPLIIC-SEL-QKAEKST
VPKP---------------------------------------------------KEKG-
-HANGDVALKVDSS---LLPPQA-------------LNVSWPPDLGPALQELKVPYF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MPWVLMEPA------AALHFS-----LPASLIL-----
LLLLRLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILTTVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-FTPDADGLFMVTTAAIIR-----D--KSMR-
NMSC-SINDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKEKKI-LSG--------EKEFELETRETAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVKR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPMRPFFRIGSDDSP-------I-FIC-PAL-IGASGVT
VPE--------EGLTLLRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEKT--G---------QSFSRYF--------VA
MLLLQ-MI------------------------------------------TPSSEQ-FTV
--------N-GIE-GPVLAPLGGKVELSCQLSPPQSAEHT-EICWFRNHY-K---K-PVH
LYKDGKDLYGE----TISNYVERTEL-LTDAIGEGKV-TLRIFSVNADDDGTYHRF--FK
-D-G---FYEEA-ITE------V--K-VT-----ATSLEM-----------------QI-
------LVHHPNAK-GL-L---V--ECNSGGWFPQPQMEWRDSRE-EIISP-S-------
------S-------------------KS-HSQDTDKLFNMEMTLLIQ-----S--TH-G-
NVTC-YLRNPV-IQ--EEKTS-------IVLS-NKLFL-------WNTVWKLILGLILAL
LLT-FTLVSSVAL-HRRLQSCS--------------------------------------
---CNAVSPWLVGILIVLTS---FSMIVSFIFYLHYK---------------KRVHVSDP
H---FELD--A--------------------MWL-EDMTV-ILCV-LMV-FITVIS-S--
S-----AHFRLRGKW--------------NGN----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLS
---V-------------------SPDSLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PS-SE--VKV
--------L-GPE-YPILALVGEEVEFPCHLWPQLDAQQM-EIRWFRSQT-F---N-VVH
LYQEQQELPGR----QMPAFRNRTKL-VKDDIAYGSV-VLQLHSIIPSDKGTYGCR--FH
-S-D--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQDLFSLETSVVVR-----A--GALS-
NVSV-SIQNLL-LSQ-KKELV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---VPGA--S----------------A----WKS-AFVAT-----LP-LLLVLAALA--
L-----GVLRKQRRSREKLRK--------QAEK-RQE---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSSR---GAPP--GP-A------------PGH--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------ARLSPAAGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDYEAGELSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIC-PLP-VRGTGVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPN-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRL-SLRLENITALDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWFPRPMAKWKGPQG-QDLSADS-------
---------------------------R-TDTNMHGLFDVELSLTVQ-----E--N-AG-
SVSC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WYL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QK-L------------PYS--
AKRFT-TQSVV-----------ASQG FH---AG KHY---WE-VD-V------GQNVGWCV
GVCQDDTD-R--R-KDS-------------------------------------------
---------------VTFSPNDGYWVFGLT--T--------EYLYFTFNPH-F-----IK
---------------------------------LSPEIPPT---RVGVFLDYEGGNISFF
NTNDQSR--IC-ILTCQFQG-L-LRPYIRHVIYE-E---KNRTPIFIC-PVS-WDQREKT
LLTG--------------------------------------------P------HTADP
DTAKGECSPQAAPA---SSPKPAHRKSRLPLS--FR-VLRF-FSPKPG----SSSSFQMR
E-----------------------------------------------------------
---DWPVPVGVRSHGCPEVGME--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGFFTVAASMIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LTS-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNQRSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASADADT---LHSK---LIPTQSSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MLDFPGYSVSGA---VASFFFIL
LSMRQPDNWRVISSTHP-ILARIGEDALLTCQLLPKKTAMHMKVTWYRSEPSTPV-FASW
DGADATEMQMEEYRGRVEFIKD-GIHEGNVALKINNIQPSDNGQYWCH FQENNYCGETSL
LLKVAGLGSA PYIHME---------GP---AE---------------------------S
GVQLVCTAKGWF----------PEPQ---VY---WADITGEKL-----------------
-LAVSEHSIQDDN--------------------------------G------------LF
YVETTLVVRNDS----------------------------------VETVSCFIHN----
PILNEEKI------------------------------SII--SIPEK-LQNELAS-LKV
--------I-GPS-EPILIRVGEDIQLTCYLSPKTNAQSM-EVRWVQSHR-Y---P-AVY
MYADGEHVTEG----QMAEYRGRTML-VSDAIDEGRL-TLQIHNATTSDNGQYRCL--FG
-K---DGVYQEA-SFD------L--K-IV-----GLGSSP-----------------LI-
------TIKEQKDG-EI-E---L--ICSSEGWFPEPHVQWKDMEG-KIIPSFS-------
--------------------------EV-LTEGSHGLFHVETSLLVT-----N--SSIV-
NITC-SINNPL-LDE-EKIAT-------FSLL-EPMM-----------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---------S---------------------WKIVLIWIL-LLVV-----------P--
V-----GLLMRKSCKKGKSGF--------F-MKIKEKEI---------------------
---------------------------------LVQE-K--KKDL---EKV---------
-LKS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------S-EV---
--------------RM-----RN-TYQ---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------E-VKV
--------I-GPG-ESILAIIGEEVEFSCHLSLYLDAEYM-EILWFRSQT-S---N-VVH
LYQERQELHEQ----QMAQFQNRTKL-VKDDIVHGSV-ILQLTGVTPADEGPYGCR--FL
-S-S--NSSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--KCSSSGWYPKPEVQWQDRRG-QCLPP-E-------
------S-------------------EA-IIQDAQGLFRLETSVVIQ-----G--GAHS-
NVSC-SIQNPL-LRQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPAP--S----------------P----WKR-AFLGT-LVG-LPLLLALLATLV--
L-----RFFRKQRWSQEKLKE--------QAEK-DKA-----------------------
------------------PNQAVS----DWRRAEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----QDGKSVSS--RGWASV--SA-V------------PSD--
PQRFTEQKCVL-----------SRERFL---AGRHY---WE-VD-V------GRRSRWFL
GACLAAVV-R--T-GQ--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------GCEYFVLEPR-R------V
--------------------------------ALTLRVPPR---RVGIFLDYEAGKLAFF
NVSDGSH--IFTFTDTF--S-GPLCAYFRPRAPDVS---EHPDPLTLC-SLP-VRGTCVL
EEN------DGVTWEQ----------------------------PY-EPD----------
------SALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MRIPRTQ-FAV
--------L-GPP-GPILAMVGEDADLPCHLVPTRSAETM-ELRWVSSSL-R---Q-VVS
VYADGKEVEDR----QSTEHRGRTSI-LRDGIAAGKA-ALRIHNVTASDSGKY-CY--FQ
-D-S--DFCEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKSYDAG-GI-R---L--ECRSTSWYPQPQIQWSDAKG-QNIPAV--------
--------------------------EAPVVADGAGLYAVAGSVTMR-----G--SSGE-
RVSC-IIRNSL-LGL-EKIAS-------ISIA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADFPSFF-----P-------T-GFFSIL----
-ALLQMST---WCS--------------------------------------AVSK-FSV
--------K-GPA-QPILVLLGADASLPCQLFPEQSAAHM-QIRWYRAQF-S---P-AVL
VYQNGQEQGGE----QMLEYRGRTEL-VQDSIGRGTV-TLLIQQIRASDDGQYRCH--FK
-E-G--YISQEA-IVE------L--H-VI-----GLGAAP-----------------HV-
------HMMGPEDD-GI-R---V--LCSSGGWFPKPRVQWSDMAG-AKLPS-L-------
------S-------------------ES-QSQDGDGLFHVEASLVVT-----D--SSLG-
NVTC-SFQNPL-SGQ-EKVSA-------LFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKK-ALAGT-LPV-----LVLLLIGM--
S-----YFGWREHKAKEREVM--------ERKKESQE-KEEMSSNKERA-LAAK------
------------EK-----LKAELD-----QRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFKP-------------APIT---L--N-HENSS
EGDS----------DP-----VRE------ENFG--KEAP-----------------SDT
--PRDCNLITL-----------EQEAFS---SGRHY---WE-VD-IKDTD------EWTL
GIYEMPMQ-G--E-GK--------------------------------------------
---------------CNDLP-KKFRVLE-K--K--------GPDYRALICSNQDISQEEL
---------------------------------VQIEKDPQ---KIVIFLGYEDGDISFY
SMTDGAH--IYSFTHCNF-F-GQISPYVKLKSYL-H-------QFK--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MGFST
---N---------------------------------SYHS---------LCL-----LT
LILLQVTR------------------------------------------LDS-VY-FDV
--------I-GPP-GPILAIVGEDARLPCHLSPNMSAEHM-ELRWFREVS-----S-AAL
VYRDGQQQEEE----QMAEYLGRTTL-VEDDINVGRV-AMKIHGVKVADGGEYRCF--FR
-Q-NE--SYEEA-IVN------L--K-VA-----ALGSDP-----------------HI-
------SVEVQENG-EI-Q---L--KCTSVGWYPDPQVQWRTPEG-KTFPS-T-------
------S-------------------ES-RIPDGEGLFTVAASVIIR-----D--TSLE-
NVSC-CIQNLL-LGQ-NKEVG-------LTIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPS-L-A----------------P----WMV-IVVVF-VTV-----LGLLSIGS--
I-----FFTWKLYKERSGMIK--------DKFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PDK--
LERFDSWPCVL-----------GRETFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTSL-R-----TP
---------------------------------LLLAEPPH---RVGVFLDYESGNISFH
NMTDGSL--IYNFLNASF-S-GPLRPLFCLWSSG-------KKPLTIC-PIT-DGHEGVT
VIVD----A------------------------KD--------FSKEIPLS---PMGENH
ASRDTDT---LHSK---LIPTQSNQG--TV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
--------FEVQGPHEL-LVATLDGEAELPCFLLPPQNVKNMEISWTRYLPSDVV-HLYE
DGRDKPEEAMKEYFKRTELVKN-VMHKGIVVLRIFNVQLSDNGQYRCAFQNGSFYSDTVI
EL KVAALGSH PQIHME---------VT---KS---------------------------R
QLRLECKSEGWF----------PQPK---VQ---WMDSEGREI-----------------
-SAESETHTQDEG--------------------------------G------------LF
HVTTSLLLREAP----------------------------------RKNLTCSVWN----
PVLNQK KE------------------------------EQL--SIAVR-LQTLLLR AFQV
--------Q-GPH-ELLVATLDGEAELPCFLLPPQNVKNM-EISWTRSLP-S---D-VVH
LYEDGRDKPEE----AMKEYFKRTEL-VKNVMHKGIV-VLRILNVQLSDSGQYRCV--IQ
-N---GSFYSDT-VIE------L--K-VA-----ALGSHP-----------------QF-
------HVEVTKSR-EL-R---L--ECKSEGWFPQPKVQWTDSEG-REIPAES-------
--------------------------ET-HTLDEGGLFHVTTSLLLR-----E--ASQK-
NLVC-SVLNPV-LNQ-KKEEQ-------LCIA-GQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MEDFP
---VS-------------------VDFLKQV-------PLPSN------LFFLTYL----
LLFLQHEE------------------------------------------AN-SEE-VKV
--------I-GPG-ESILAIVGEEVDFPCQLSPLLDAEDM-EIHWFQSQP-S---D-VVH
LYKGRQELFDR----QMAQFQNRTKL-VTTEISSGKV-VLLLRSVVPSDEGLYGCS--FL
-S-N--NFSGEA-IWE------L--E-VA-----GLGSDP-----------------HI-
------YIEGFKEG-GI-Q---M--RCTSNGWYPKPKVQWKDHQG-QCLPL-E-------
------S-------------------EV-ITQDVKGLFNLETSVVVQ-----G--EAHR-
NMSC-SIQSPL-LIQ-KKEFV-------VQIA-GLQDSTTMPAQC---------------
-----------------------VYFHFNVQHFLIQ-VDKFKSNSFPPDPT---------
------------ERCQ-----------------GSSYH--TYFTLDS--RTIPAGCFPDV
F---LPGT--S----------------P----WKS-AFLGT-LVA-LPLLLALVAMLA--
L-----YYLHKQQQSQG-MRQ--------ARE----------------------------
-----------------------------SPSYRRK-----EGRK---EGR--K----AA
I-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------L---R--T-NLQSH
PSLE----------VS-----KDAKSVSSRPV---VPIL---A------------DGC--
PQRFTEQTCVL-----------SRERFS---TGRHY---WE-VH-V------GRRSRWFL
GACLATVQ-R--S-GP--------------------------------------------
---------------ARLSPAGGYWVMGLW--N--------SCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RVGIFLDCEAGKLSFF
NVSDGSH--IFTFTDTF--S-GALCAYFRPRAHDGG---EYPNPLTIC-SWP-ARGTCVP
EEN------DLDCLLQ----------------------------PY-DPL----------
-----DTDLG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------M-NEN-GKFPGL--PSSQLSCLRPFASAAHAS--LSSVCCGW-T---A-WAH
PGHDGKEVEDR----QSAAYRGRTSI-LRDDITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-ENIPAV--------
--------------------------EAPVFADGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQYT-------
------------------------------------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LELPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KEEENSS
NS--D--RV----------------------VIIR--------CLPRDTSD------PGL
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRITF-VSKGISRGSV-ALVIHNVTTQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPALK-------
--------------------------EV-SITDADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLHYEAGDVSFY
NMRDRSH--IYTCPHSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAVT-CNRE-AFLSIC------------F--VT
LVFPQLPLASIW-----------------------------------------KAD-FDV
--------I-GPH-APILAMAGGHVELQCQLFPNISAEDM-ELRWYRCQP-S---L-VVH
VHKRGMDMDGE----QKWQYRGRTTF-VSDHVARGKA-TVRIHRVIAFDNGTYCCR--FK
-D-G--VKFGEA-IVQ------V--K-AA-----GLGTEP-----------------RI-
------QVMDQQ-D-GV-R---P--ECTSAGCFPKPWVERRDFRG-QARPA-V-------
------T-------------------NL-SASATTRLWAVAPSLKLW-----D--RAVE-
GLSC-SISSSL-LPE-R-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVELPGYSLSGV---FASFFFVL
LSMKQSDDFRVMGSAHP-ILAMVGEDALLTCQLLPKRTAKHMEVRWYRSEPSSPV-FLYR
DGDEVTEIQMEEYRGRVEWIED-GVTEGSVALKIHSLRPSDHGQYWCHFKDGNYLAETSL
LLQVASLGSDPYIHMD---------GS---VE---------------------------S
GLQLVCTAKGWF----------PEPQ---VS---WKDIKGENL-----------------
-LAFSNYNFQDED--------------------------------G------------SF
YVESTLVVRDAS----------------------------------TEAVSCFIHS----
PSLAEEKG------------------------------SDI--SIPEK-LQAELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCSLAPRTDARSM-EVRWVRSHR-H---P-AV-
-YTDGARVAGE----QMAEYRGRTVL-LSDAISEGRL-TLQINDARTSDDGKYRCL--FE
-K---DGVYQEA-DLD------L--K-II-----GLGSSP-----------------QI-
------SVEGLKDG-EV-K---L--KCTSEGWFPRPHVQWRDMEG-NPIPSFS-------
--------------------------QD-LTQGSQGLFHVEAFLLVT-----N--SSVV-
NVTC-SISSPL-LGE-EKKTT-------FSTS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------I
Y---------S---------------------RNILPIWGL-PIWGIGILSILLLVGV--
V-----GLIWRKSRRKGELEQ--------K-QHGTDLGK---------------------
---------------------------------VLKS-S--E------------------
--VR--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------L-R----
---D----------TC-----K--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDFSRCS-----G--------LSHLTIL----
LLLLPLPT---GGS---------------------------------------TET-FRV
--------I-GPL-HPIVAVLGGEAVLPCSLFPAVSAEDM-ELRWFRSKL-L---E-AVF
VYQNRQEQKEE----QMALYAGRTSL-VGDLLSQGYA-AVRIQRVQASDNGLYTCV--FR
-K-G--HFYEKA-GLE------L--K-VA-----GVGSAP-----------------QV-
------RITGPEED-GV-R---V--VCTASGWFPKPQVQWRDVSG-EKFLA-F-------
------S-------------------EA-HTQDAEGLFSVEAALVVR-----D--SSVG-
NVTC-SILNPV-LGQ-EEAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFSVS-LTV-----LVILLLGA--
G-----CVTKKEHSMKVQEMR--------EKETLCQT-REQDRQTKEEV-LKDA------
------------AK-LQ----EELE-----RRKSTY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQAW-------------PVT---L--D-PGSAH
SDLV----------IS-----HEKTSVTLKAS-Y--V-----------------------
--NSGDTCSVL-----------GFEGIT---SGGCY---WE-VE-IRDGD-ES---EWAL
GVCREGVN-R--K-GW--------------------------------------------
---------------YVESLDKGFWVVG-R--V--------ERGYCACTAPVT------P
---------------------------------LSLMQAPHPRLRVGVFLDHQEGDVSFY
NMTDGSHL-IFSFPQASF-S-GTLFPYFMIRSGD-V-------SLTVC-SKV-GGSEGLP
VALS----N------------------------P----------SLEESVSLPG-AGFSS
GSGADG-PPGAESP---LLPCNPEAV--SP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFP
---V-------------------SLDSLQPV-------SLPSS------LIFLTRLLFL-
--LLHPGE------------------------------------------L-HSEE-VKV
--------V-GPE-EHILALVGEEVDFPCHLSPYLNAEHM-EIRWFRGQA-A---D-VVH
LYRGRQELPGW----QMAQFQNRTEL-VTDYITDGSV-LLRLHHVVPADQGPYGCS--FL
-S-G--NFSGEA-AWE------L--E-VA-----GLGSDP-----------------HL-
------SLDGFKEG-GI-H---L--KYSSSGWYPKPKAQWRDHQG-QCLPP-E-------
------T-------------------EV-ITQDAQGLFSLETSVIVQ-----G--GAHR-
NVSF-SVQNLL-LSQ-KKEVV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------P----WRR-AFLGT-LAA-LPLALAVPGTLA--
L-----CLLQRRRRSQEKLNQ--------QAEK-KQG---KL--TAE---L---------
-----------------EKLQREL----EWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSSR---RVAQ--GP-A------------PSD--
PQRFSEQTCVL-----------SIQRFS---AGRHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------ARLSPACGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RVGVLLDCDAGKLSFF
NVSDNSH--IFTFTDAF--P-GMLCAYFRPRAYDGR---EHSDPLTIC-QLP-ARGTHIP
EEE------DNDTWLQ----------------------------PY-DPA----------
-----DQALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---K---------------------------------SCLH---------SCL-----LI
LACLPLSK------------------------------------------PDS-AQ-FDV
--------I-GPP-EPILAAVGDDVELPCHLSPNVSAERM-ELRWFRGKV-A---A-AVL
VRRDGREQDGE----QVAEYRGRATL-VDRDIAAGRV-AVRIHQVRASDDGEYRCF--FR
-Q-DG--SYEEA-SVH------L--K-VA-----ALGSDP-----------------HI-
------HMEVQENG-EV-R---L--ECTSVGWYPEPHVQWRTSGG-EQFLS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--PSMK-
NISC-SIQNLL-LGQ-EKEVD-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WMV-AVAVI-LMV-----LGFLTVGS--
I-----VCTWRLYKERSRQRK--------DEFSSK-------------------------
-------------------------------EKLLE-EL---RWK---KATVH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSRSVRLEDS----R--QE-L------------PEK--
PERFDSWPCVL-----------GRETFT---SGQHF---WE-VE-V------GDRADWAV
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNRYWALTPL-R-----TP
---------------------------------LPLAGPPH---RVGIFLDYEAGDVSFY
SMTNGSH--IYTFSNASF-S-GPLRPFFCLWSCG-------QKPLTIC-PVT-DEPERVT
VVAD----A------------------------EA--------FVGFCSRQ---LA----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFS
---N----------------------------------FLL---------GCL-----LT
LMLLQLPT------------------------------------------LDT-AP-FEV
--------L-GPL-EPILALLGEDSELPCYLSPSMSAEHM-ELRWFRNTF-S---P-AVL
VHQDGQEQEGE----QMPEYQGRVTL-VTENITAGHA-MVRIHGIRTFDEGVYGCS--FR
-D-DQ--VRGEA-FLQ------L--R-VA-----ALGSDP-----------------HI-
------GMEVQESG-EI-W---L--QCTSVGWYPEPHVQWRTPTG-EKFLS-T-------
------S-------------------ES-KSPDQDGLFTVAASVIIR-----D--TSLE-
NVSC-CIRNLL-LGQ-QKEVG-------ISLS-APS------------------------
------------------------------------------------------------
------------------------------------------------------------
--------S-P----------------F----WSF-SM------V-----AVFMGFVG--
I-----FIIWQLYRKCRKKER--------NDEIS--------------------------
-------------------------------------PI---EWK---SARSY-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVPVT---L--D-EDTAH
PHLL----------LS-----EDLKSVRLEES----R--HD-R------------PEN--
PERFDSWPCVL-----------GKKP FT---SG KHY---WE-VE-V------GDRPDWLV
GVCREDVM-K--K-GF--------------------------------------------
---------------ILMSPKNGFWVVELS-----------GKEYWALAPL-R-----VL
---------------------------------LSLPEAPR---QVGIFLDCESGTVSFY
NVNDGSH--IYSFPKVSF-S-GPLLPIFCLWSCD-------KKPLTIC-PVAADGPVEVT
VMAD----A------------------------QT--------HQR--LLP---PMGQ--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEMA------SSL----------AFLLLSFHVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPP-GPILAMVGEDADLPCHLVPTRSAETM-ELRWVSSSL-R---Q-VVS
VYADGKEVEDR----QSTEHRGRTSI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DLKGYEAG-GI-H---L--ECRSTGWYPEPEIQWSDAKG-ENIPAVE-------
------V-------------------EAPVVADGAGLYSVAGSVTMR-----G--SSAE-
QVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FWSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----FFLWRQQKEIIAL---------SRETEREREMKELGYAGTK-------------
----------------QQIS---------IREALRE-E---LKWR---KIRYLA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
PILL----------VS-----EDQRTVQRAEE----P--RD-I------------PDN--
PERFEWRYCVL-----------GCGS FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LTLPESPR---KVGVFLDYETGDVSFY
NAVDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KGVESSP
DP--D--L-----------------------VASD--------HPLETPVA------PGL
ANQSGEPQAEVTSL---LLPAQPGA-DSLPLH--------S-NQAEA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKM-ASSP-----G-----SSLSGCFI-----T
LACLQMLV-------------------------------------------QGSDR----
--------T-GDASKFHLAPLGGTAELLCPLSLWPALEPT-EVRWQRSPPPQ-LSQ-AVH
VFRNGRDWDES----LLPEYKGRTEL-VRDA-REGSI-TLKIRDVRLEDRGQYYCQ--VQ
-I-S--NLSREG-SVS------L-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------QV----
------------------------------------------------------------
-----------------------------------------------------AAPSLGR
V---S-----S---------------------ST-VALAVV-LSV-----LALLLVAG--
T-----YLIWKQRRTKEKLLYE--QAMEVX-XXXXXXXXXX-XR----------------
---------------------------------LH-------------KGL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSXXXXXXXXXXAVT---L--D-PDTAH
PKLV----------LS-----ADRRCVRLGER----R--QP-V------------ADN--
PQRFDFVVSVL-----------GSEXXX---XXXXX---XX-XX-X------XXXXXXXX
XXXXXXXX-X--X-XX--------------------------------------------
---------------XXXXXXXXXXXXXXX----------XXXXXXXXXXXXX------X
---------------------------------XXXXXXXX---XXXXXXXXXXXXXXXX
XXXXXXX--XXXXXXXF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QTSEE--
---P---------------------------------------------------KGKG-
-HANGDVSLKVDPS---LLPPQAAEP--FPFR---DVVLPWPSDLGPALQGLRAPFL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MPCLRAPKLSPN----------------
---------------------TPAPKIMNMA------YFPDHS-----VLSG--L---VA
VLFLQLLT-------------------------------------------MISAQ-FTV
--------V-APA-KPLLVMVGEDAILHCHLFPKKNAEQM-EVRWFRSQF-S---P-AIY
VYKDGKNRDEE----QMEEYRSRTTF-MRDNIKDGSV-ALKIHNVTAFENGRYHCY--FQ
-E-G--RSYDEA-FID------L--K-VA-----SMGSDP-----------------LI-
------EITGYEYG-WI-Q---L--ECTSAGWYPQPRVEWRNLSE-ETIPSLE-------
--------------------------EN-LVPSEDGLFIVKLSVNIT-----D--HTVV-
SVFC-SIQNSL-LSQ-ELLAM-------MSIP-GH--P-------SEIPDLITTPS----
------------------------------------------------------------
------------------------------------------------------------
----PEEV--S----------------T----WMV-ALTVA-LPALGLF-----IAC--S
I-----CFTCKQHKRKKT-LFI--------EKEIECEEKDEK------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----GQEQMDHLTGW--------------------RRIQLHAADVT---L--D-QNTAH
PELY----------LS-----QDLRSVIR--GDTR----QD-L------------PDN--
PERFDCRPCVL-----------GCESFT---SGRHY---WE-VE-V------ADVMVWAL
GVCRENSE-R--K-GE--------------------------------------------
---------------ALLIPQNGFWVIELF-----------GNRYQALTSPDI------L
---------------------------------LPLSDHLY---RVGIFLDYEAGDVSFY
NMIDRSH--IYTCPRTSF-S-GPLRPFFRLGSDDNP-------L-VIC-PAF-TGAEGVT
VPE--------SGLILYRRPY---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHGC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSALYRGRTSI-LRDDVTAGKA-ALRIH-VTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VAGEP-PGFVL----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-RTFL-----------------W----------RHY---WE-VE-V------GDRKEWNI
GVCSKNVQ-R---KVW--------------------------------------------
---------------VKMTPENGYWTIGLT--D--------GNKYRALTEA-R-----NN
---------------------------------LKLPEPPK---KVGIFLDHETGEISFY
NATDGSH--IYTFPHTTF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--D-----------------------LVPD--------HSLETPVA------PGL
ANENGEPRAEATSL---LLPAQPGL-RASPST--------A-TNHNHKATGTH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPD-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQL-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRL-SLRLENITALDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSDWFPWPIAKWKGPQG-QDLSADS-------
---------------------------R-TNTNMRGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQEA----WA--------GDL----------------------------
------------------------------------------FMV---PAGT--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------GSEML---------------------PH
P-SC----------FS-----S-SSPSLQGPR----P-----------------------
-KKVI-TLL---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MLRKSRP
---FKLETE-KS----------SS-EEMENCSSHL-----L--------LCRLASL----
LLVLQLPT---WAS---------------------------------------ADE-FLV
--------I-GPW-EPVVAVLGGDATLPCSLSPASSAEDM-ELRWFRGRF-S---D-AVL
VYRNRREQSAE----LMAQYAGRTSL-VTGGLALGEA-AVRIRHVRASDHGMYTCF--FR
-K-G--AFYEEA-TLE------L--K-VA-----GVGSAP-----------------HV-
------RIDGPEDG-GV-R---V--LCTASGWFPKPQVQWRDVSG-ERFLG-F-------
------S-------------------EA-HAQDAEELFSVEAALVVR-----D--SSVG-
NVTC-SVLNPV-LGQ-EKATA-------VFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFAVT-MVT-----LGVLLFGA--
G-----YFIQRERATKLQERQ--------EGEKLRRE-KEEDRKAREQA-RKAG------
------------DE-LQ----ADLE-----RRKDAY--M--VAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RT------EQFQAW-------------SVT---L--N-AGSAH
SNLA----------IS-----QDKKSVTWSD-TC--V-----------------------
--DSQGIFSVR-----------GLEGIP---SGRCY---WE-VE-VRHGD-NC---QWAL
GVCREDVK-R--T-EW--------------------------------------------
---------------HRECPEKGFWVMG-R--Y--------DDGYRACTNPDL----TTE
---------------------------------LRLRQAPH---RVGVFLDYSEGDVSFY
NMTDGSH--IFSFPPASF-S-GTLFPYFRLMSGD-V-------SLTLC-SVV-GGPKGLP
VPHH----I------------------------S---------SSLEEPESSPG-EGFGS
GSGVGGAPPGVESP---LLPCGPEAV--PV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------CFL----------TFFLHTFLVY
HVLVH-------------------------------------------PLTPCSAQ-FAV
--------H-GPP-GPILAMVGEDADLPCHLSPSMNAETM-ELRWVSSSL-R---Q-VVN
MYEDGKEMEDK----LSTEYRGRTLI-LRDGITAGKA-VLRIYNVRASDSGNYLCY--FQ
-D-G--NFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------EVKSYEDE-GI-H---L--ECKSTGWYPQPQIQWRDAKG-ENIPAV--------
--------------------------AAPVAVDRVGLYAVVSSVIMR-----G---SGE-
GVSC-TIRNSL-LGQ-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DS
F---FSNA--Q----------------H----WIK-ALAGT-LPI-----LLLLLTGA--
G-----YFLWRQQKENKIL---------LRKKMREQEMREMAWRTKE-------------
----------------NEQS---------LKEKLQE-E---LKWR---KIQYMT------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SQ--------------------AYAEWKVALFQAADVI---L--D-PDTAN
PILI----------VS-----EDRRSLLRAEE----R--QD-L------------PDV--
PERFDWHYCVL-----------GYES FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNIQ-R---KGW--------------------------------------------
---------------VKMTSEHGFWTMGLS--D--------GNKYRALTDP-R-----TK
---------------------------------LTLAEPPR---RVGVFLDYETGEVSFY
NAMDGSH--IYTFLHTSF-S-EPLFPVFRILTLEPT-------ALTIC-PAA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------FKIRKYLVS-NTII-F--------------ILCL--PI
YVFLNLFTYDP--------------------------------------QIIVLGQ-FHV
--------I-GPK-APVIALVGEEALLPCHLSPLMDAQDM-EVKWYRNHP-F---G-LVH
QSENLKDYMEQ----QMPEYQGRTEFLLKDNITKGHV-ALRIHHIRPSDGGEYRCS--FE
-K-S--IYFQEA-HFQ------V--L-VT-----GSGTAP-----------------HI-
------HIGHGETK-GL-T---L--TCTSVGWFPEPEVQWRDLQG-QRLAP-A-------
------S-------------------ET-KTPERNGVFHVETSITLD-----K--SSKE-
NVAC-YMRNPV-LGV-EKEVH-------ISVT-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPRV--S----------------P----WPV-IAPVI-VVL-----LVITGIVC--
V-----LLMRARKAK-GNFGS--------S---IICQ-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------GTRG------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------FGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDWREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASMIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRETFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASADADT---LHSK---LIPTQPSQG--TP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MANFL
---VS-------------------MECLKRV-------PLTSS------LLILTHL----
LLYLQLGK------------------------------------------AD-SGK-VKV
--------I-GPG-ESVLALVGEEVEFSCHLSQYMDVEHM-EIRWFWGLA-S---D-VVH
LYQDGQELFGE----QMVQFKNRTKL-FRDEMATGSV-ILRLHNVVPSDQGLYSCR--FL
-S-S--NFSGEA-IWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPQVQWRGHQG-QCLPP-E-------
------T-------------------EA-IVQDVQGLFRLETSVVVQ-----G--RAHR-
SVSC-SIQNPL-LIQ-KKEFV-------VQIA-GQLYAHSPFSLSL--------------
---------------------------FSLFFFFFSEWKAAQQYA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------VN
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PDTAH
PSLE----------IS-----EDGKRVSSRPG---P---PT-P------------VAS--
YPRLSEHKCVL-----------GRER FS---SG RHY---WE-VH-V------GRRSRWFL
GVCLAAAP-H--S-EP--------------------------------------------
---------------TCLSPAGGYWVLGLW--N---------CEYFALDPH-R------V
--------------------------------ALTLRVPPR---RIGLLLDFEAGTLSFF
NVSDGSH--IFTFSDSF--S-GTLCAYFRPRAQDGS---EHPDPLMIC-SLP-IKDTSLE
ALRPHPGPAVGLSW----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----VIPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRRELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEYFT---TGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
--LLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-VPILAMVGENTTLHCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRERTEE----QMKEYRGRTTF-VSKDTSRGSV-ALVIHNVTAQENGTYHCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GFGSKP-----------------LI-
------EIKIQEDR-SI-R---L--ECISRGWYPEPLTVWRDPCG-EVVPALK-------
--------------------------EV-STPDADGLFMVTTAVIIR-----D--RSVR-
NMSC-SINNTL-LGQ-KKESV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILAT--S----------------P----WTV-ALAVI-LVIFIIF-----MAV--S
I-----SCIKKLQREKKILLSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVKR--GPFR----QS-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMKDRSH--IYTCPRSVF-S-VPMRPFFRLGSDDSP-------M-FIC-PAL-TGADGVT
VPE--------EGLTLHRAGTHRSPQDQFPGLTAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVTTMARMCQELCSSDVQETHKPGTKHFAIFPFVPLTATSVSTEG-FRV
--------F-GPS-DPVVVAPGREAILPCSVSPAMSVENMEELRWFRTRF-S---E-AVF
VYRDQEEQKEE----QMIEYSLRTSL-VKDQFHEGKA-AVRIQNVQESDSGIHVCH--FK
-Q-G--VLYEEA-ILE------L--K-VA-----AMGSTP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSTG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTETSLVLR-----D--SSVR-
NVAC-SIFNPV-LGQ-EKAIA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFIVI-LTM-----MGLLVSGT--
S-----YLLIREHSGRLKLQQ--------EWSHFQLE-KDELQTIKEDA-L---------
------------RT--ASALREELD-----RRKATY--N--RAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RR------EHFQAW-------------TFT---L--D-PASAH
PTLV----------IS-----QDRMRVTRKDTNE--L----------------------F
RVLSIDLFSVL-----------GTKGIS---SGRYY---WE-VK-LANGE-GS---KWSL
GVCREVVE-R--K-DF--------------------------------------------
---------------YFESPEKGFWTVG-Q--S--------SCGYFAYVERGR-----AS
---------------------------------LSIRQAPQ---SVGVFVDYDEGEISFY
NMSDMSH--IFSY-EASF-S-GTLLPYFRLKSGN-V-------SMTVS-TMA-CVSEGQE
GEEG----EKGEEQEEGK------------------------------------------
--------EGEECQ---LLSHARDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-FLPSLLA-------------------------------------------HSTAQ-FTV
--------V-GPD-QPVTAVVGDDVVLPCHLCPRMSAENM-EVRWFQRES-I---P-FVH
LYRYGKDKFGQ----QMSKYRGRTEL-SKAGITDGNV-ALRIVNVRPSDEGQYHCF--VQ
-D-G--ASYEET-VLE------L--K-VA-----ASGSAP-----------------HI-
------SVEDYQDG-GI-R---V--VCRSAGWYPEPEVVWRDLNG-QAFPS-A-------
------S-------------------QT-NSQEANGLYGTQTSAIVM-----E--NSNR-
NLSC-LVRNTR-LSQ-EKEST---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPKV--N----------------P----WKV-SLDMMILVV-----LFGFIALS--
V-----YLFKIKGHAYVLMLL--------TEG--LCP----AWTLGHS---GTLLF----
--------L-LPRQRTQESMGGSL---LCQGKG---------------------------
------------------------------------------------------------
---------------------P--------------------------------------
--------ESASCHGW-D------------------RDTP-APSAWL---L--G-PDPAN
PLLV----------LS-----EDGKRVRWEQK----R--QP-L------------PDT--
PERFDTCFCVL-----------GREGYT---SGKHC---WE-MG-V--GD----GRYWAV
GVATESVS-R--K-GG--------------------------------------------
---------------MSLSPQGRIWAVR-W--W--------GDEFQALTDP-A-----TS
---------------------------------LPLR-HPS---RIRVCLDCDWGQVTFM
DAGSNAP--IFTFPPGSFS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAT---SPK-SCLPGG------------L--L-
LLLLQLPW-------------------------------------------IRAAP-FEV
--------V-APA-EPVLALVGEDAELPCRLSPNVSAAHM-ELRWFRGTF-S---P-AVL
VFVDGREQDRE----QTAEFRGRATL-VADGIPEGRA-TLRIRGVRVSDGWQYQCL--FR
-E-D--RHTAEA-TVQ------L--R-VA-----ALGSDP-----------------VV-
------HTEVQASG-EI-R---L--QCSSTGWYPAPQAQWRTPTG-EELPA-T-------
------Q-------------------EA-SSPDADGLFAVATSV--VLGDSSL--R----
NVSC-HIQNPL-LGQ-QKEE----G---VLLP-X--------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------X--XXXXX-XXXXX-XXXXXXXXXXXXXXXX--
X-----XXXXXXXXXXXXXXX--------XXXXXXXR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------LLEELRW-K-------------------TASLHAVDVT---L--D-PDTAH
PHLF----------LY-----EDAR-------------------------------SV--
RLEDTRQRLPE-----------KAE-------RFDS---WP-CV-L------AGETT---
GVVGRNVT-------G--------------------------------------------
---------------LDMTPENGFWT-E-L--Y--------GNE-YALTPL-Q-----TP
---------------------------------LPLAGAPR---RVRVFLDYESGAVSFY
NTEDGSH--IYTFPQGSF-S-GPLRPFFCLWSCEKK-------PLTIC-PVA-GGPVGVS
VTAT----A------------------------PD--------LSKEMALCPL---GEDP
ASASVDT---LHSK---LIPTHPSPV--TP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVT---------------------------------------TKG-FWV
--------F-GPS-DPVVAAPGREAILPCSVFPAMSVENMEELRWFRNRF-S---Q-AVF
VYRDQEEQKEE----QMIEYSWRTSL-VKDQFHEGKA-AVRIQNVQESDSGIYVCH--FK
-H-G--HFREEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSRG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTENSLVVR-----D--SSVR-
NVTC-STFNPI-LGQ-EKAMA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKT-AFVVI-LTM-----MGLLVLGT--
I-----SLFGWERFVRLKLQK--------EQIHIHCE-KDKAQTEKEDA-L---------
------------RT--AKWGYCEWV-----LTRVCS--F--TAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQTW-------------TFT---L--D-PASAH
PTLV----------IS-----QDRMRVTRKDTTV--C-----------------------
---LDDLFSVL-----------GTKGIS---SGRYY---WE-VK-LANGE-GS---KWIL
GVCREGVE-R--K-GF--------------------------------------------
---------------YFESPEKGFWTVG-Q--S--------SSGYWAYVDSGR-----DS
---------------------------------LSIRQAPQ---SVGVFVDYDERNISFY
NMSDKSH--LFSFHEASF-S-GTLLPYFQLKSGN-V-------SMTVS-SMA-CVSEGQE
GEEG----EKGEEQEEGK------------------------------------------
--------EEEESQ---FLQRVRDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----VMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EEKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLL---------GCL-----LI
FIALQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAMLGEDAELPCRLSPNMSAEGM-ELRWFREKV-S---P-AVF
VSREGREQEGE----EMAEYRGRVSL-VEDHIAEGSV-AVRIQEVKASDDGEYRCF--FR
-Q-DE--NYEEA-IVH------L--K-VA-----ALGSEP-----------------HI-
------SIKVQESG-EI-L---L--ECTSGGWHPEPQVQWRTHKG-EEFPS-M-------
------S-------------------ES-RTPDEEGLFTVRASVIIR-----D--TSMK-
NVSC-CIRNLL-LGQ-EKEVE-------ISIP-ASF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WLV-AVAVI-LVV-----LGLLTIGS--
L-----FFTWRLYKERSRQRR--------NEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVM-----------GREAFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGVFLDYESGDIFFY
NMTDGSH--IYTFSKASF-S-GPLRPFFCLWSCG-------KKPLTIC-PIT-DGLEGVM
VVAD----A------------------------KD--------ISKETPLS---PMGEDS
ASGDIET---LHSK---LIPLQPSQG--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------FASHL-----PFLQAAFH--MP
RTLIQPLP-------------------------------------------PFSST-FSV
--------K-GPP-DPVAVAVGQDVVLPCHVSPAQSVQDM-EVTWFREQF-T---P-FVH
RYKDRQDQYGD----QMVQYQGRTEL-LKDSLTNGSV-DLRIFRVQLSDKGLYTCF--VR
-S-D--SGYDEA-VVE------L--K-VT-----ASGSAP-----------------RI-
------VLEHYQDG-GI-R---V--ACRSAGWFPQPQVLWQDHCG-QHLPS-L-------
------S-------------------EN-ITQDESGLFATESILILT-----R--SASQ-
EVAC-VVRPAL-QSQ-EKES----S---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FQNA--H----------------P----WKI-GLGVV-LVA-----VLSLFIIA--
V-----YLFRMKGTQLCISTK--------TKQN---KN-----------LFS--------
-----N-----ASRRTVSEVALK-------------------------------------
------------------------------------------------------------
---------------------K--------------------------------------
--------RQAEELEW-RRYAVPVENVSSAGHALEMHGLLQPGVAVV---L--D-SDTAH
CDLV----------LS-----DDCKSVKREDK----L--QN-V------------PSL--
PQRFDPWRCVL-----------GCEGYT---SGRYY---WE-VE----VV---DGGGWAV
GVSREDVK-R--K-GE--------------------------------------------
---------------IQFSPEEGIWAVG-N--W--------AGKFKAFTSPEH-----TC
---------------------------------LHESQAPT---RVRVSLDYEVGRVAFF
SVDEKNS--IFTFPLASF------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MLKWLKKH-V---------VAWK--------------------------------MCVMP
HSRK-------------------MSVHMERP-SPC-----G-----SWLVGCLF-----T
IAVFQPPV-------------------------------------------QV-------
--------L-GDAGKVYIAPLRDTANLPCPLFLWPNMVLS-EMRWYRPGHLPRT-Q-AVH
VFRDGQDRDED----LMPEYKGRTAL-VRDA-HKESY-ILQISNVRLEDRGLYQCQ--VW
-V-G--NSSRED-NVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-E---L--LCQSVGWFPKPWTEWRDTTG-RALLSLS-------
--------------------------EV-HSLDENGLFRTAVSSRIR-----D--NTLG-
NVSC-TIHNEA-LGQ-EKTTA--------------------------------MII----
------------------------------------------------------------
-----------------------------------------------------GAPERGS
L---S-----S---------------------PA-VALSVV-LPV-----LGLLILLG--
I-----WLICKQKKSKEKLLYD--QAMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PERFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGIFLDYEAGIISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---KNTAPLIIC-TEL-QKSEESI
VPKQ---------------------------------------------------EGKD-
-RANGDVSLKMNPS---LLSPQGSEL--FLLN---DT---WPSNLGPALKGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLQLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MYRDGKDQDED----VMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWNQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-I------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEEST
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEP-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKM-ASSS-----G-----SWLSGCLV-----T
LISLQLPS-------------------------------------------QA-------
--------S-GDAGQSRLAPLGGTAELLCPLVLWPATVPV-EVRWLRSSAPG-HPQ-RVH
LFREGKDLEEG----VMPEYKGRTAL-LRDA-RDGSV-TLEIRDVRLEDRGQYKCQ--VQ
-I-G--NLSREG-VVT------L--Q-VA-----VLGSEP-----------------YI-
------HVQSYDAG-WI-Q---L--VCKSAGWFPKPWAQWRDPQG-KVFPSLW-------
--------------------------ET-HSLDEAGLFRTAVSNRVR-----D--STLG-
NVSC-TIQNVA-LGQ-ERTTA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGS
F---S-----S---------------------SE-VALAVI-LPL-----LGILIVLG--
V-----YFIWKQRRSRGNDVRG--KGAQAE-NLLSDHAKEKGNC----------------
---------------------------------FP-------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------NLPFLCLSAVAVT---L--D-PDTAH
PKLI----------LS-----GDRRCVKLGDT----R--QP-V------------LDN--
PQRFDFVVSIL-----------GSEH FT---AGC HY---WE-VS-V------ADKSKWAL
GVCSESVN-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------RQGEYEALTSPPT------S
---------------------------------FRLKEPPR---CVGVFLDYEAGVISFY
NVTGRSH--IFTFTHSF--F-GPLRPFFEPCLHDGG---KNIAPLVIC-SEL-QKLEEPT
VPKP---------------------------------------------------EERG-
-RANGDVALVVAPS---LLPAQAPEL--GPLR---DVVLAWPSDVTPALQGLSVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVY
LLLVQ-------------------------------------------LLTPFCCA-WT-
----------------PWAHPGEDSDLHCHLFLTVSAETM-ELRWISSSL-R---R-VMN
MYVDCKEVEDR----QSAEYRGRTSI-LQDGITAGNA-ALRIYNVTASDNGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDI-----------------HI-
------EVKGYEDG-GI-H---L--GCRSTGRYPQPPIQWSNTKG-ENIPAV--------
--------------------------EAPMVADG-----VAASVIMR-----G--SSGE-
GVSC-IIRNFL-LGL-EKTAS-------ISIE----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--K----------------P----WIT-ALAGT-LPI-----SLLLLTGA--
S-----YFLQQERKEKTAL---------SRETEREREMKEMGYATK--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------KWKMALFKPVYVI---L--Y-PDMAN
AIVL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PERFEWRYCVL-----------G----------S HY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKVW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------ENKYQALTEP-R-----TN
---------------------------------LKLPEPLG---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTS-KEAESSP
-D--P--D-----------------------LVPD--------HSLETSVT------PGL
ANESGERQADVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MRAR---G---VLV--------THC------VI
LYLLQ-MV------------------------------------------ALSSEE-FTV
--------A-GLT-RPVLAPLGGNLELSCQVFPPQNAQHM-EIRWFRNRY-T---Q-PVH
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLRIFNVTADDDGPYHCV--FK
-D-G--KFYEEH-IAE------V--K-VT-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

---------------------------------------MEPAFSCVTG--YS--VAILL
QMVVLPSVLRMENKTSHMFKKVEGGRAELSCQLSPPECRAHAD--------GQPV-YLYK
DGGEVSGKSTYNNVNRTVLLKD-TLGEGKVTLRIRNISVLDGGQYYCFFKDG----EAIM
DLRVAVLGLLIQVEIS---------VLI--AS---------------------------R
GKASNCLVSIWVWSG----VDVPGSS---LS---WASSFQSFLFLLPEVLLKNKTT---T
KKNPRQAVTRGRN--------------------------------GYTLPAELMNFRKLL
HFVGSINFRPLSIYKVIVTRPLLFLDLIPRLIMCYT-AEHSNR-IRSWGLMSLIYN----
IVLASALF-------------------------------TI--YLAEK-H-------LHF
--------N-PPS-FPV---SDSDALF-----------PL-YTTWIRDIC-V---I----
--L-------------------------------------T--VLMIFSPAFISCL--L-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------LE----------MGDSAMILA---------L-------------SC--SF
SFLPWFLM-------------------------------------------NPIGQ-FTV
--------V-SPD-KPIWANFGEDTELHCFLAPRTNAENM-EIRWFRSND-S---S-LVH
LYREGKDQEAE----QMPKFRGRTTL-VKNAIVDGNI-VLRIHKVRVSDAGNYTCQ--FQ
-S-D--KHLDAA-TCE------L--Y-VT-----SEGSAP-----------------SI-
------HIEGLGTE-ER-R---L--LCRSAGWYPEPRVQWKDSAE-ETVSK-K-------
------S-------------------EPIMTQDADGLYQVEAGFILR-----K--NTNR-
TVTC-SILSPV-LRQ-EKETS-------VPVA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------K
D---FPQTNSG----------------V----WGL-AVSGT-VNV-----ICLLIIAA--
-------LLW--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVKPE--FS---HFF--------GFC------VY
FLFLQ--V------------------------------------------MASSEK-LRV
--------T-TPT-RHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGH-S---Q-PVY
LYRGGHKMSEE----AAPEYANRTEF-VKEAIGEGKV-SLRIYNINILDDGPYQCS--FN
-D-S--GFIDVA-IVN------L--K-V--------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------T-DELFN-------QDYLWVGIIPSSVGS
L-ILFGVLQFINSFFRRRGCAS-----------------------------------GCL
SKCLPVVTSWPVQIVH--FL---VCSGVLFAVYLPHR---------------YRGKWNQ-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------CSL--------GTG-------AALS-G---------------WSQVVSV----
------------------------------------------------------------
-----------------------------------------------------SAESPDS
F---S-----P---------------------SA-VALTVI-LPV-----LGIFIVVG--
L-----YIIWKQRRSKERLLYE--HAMEVE-NLLSDHAKEK-GN----------------
---------------------------------SMY------------SIR---------
------------------------------------------------------------
------------------------------------------------------------
-------EKLRRELKL-----------KRAAANSGWKRARLHFVTVT---L--D-PDTAH
PKLI----------LS-----EDRKCVKLGDT----R--QP-V------------PDN--
PERFDFVVSVL-----------GSEYFI---AGCHY---WE-VS-V------ADKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------QWNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
DVTNQSH--IFTFTHSF--S-GPLRPFFEPCLRDGG---KNTAPLIIC-SEL-QKPEEST
DPNT---------------------------------------------------EEKG-
-QANGEVPLQVDPF---LLPAQTSEL--VPLK---DMILSWSSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-FLPSLFL-------------------------------------------YSTAQ-FKV
--------L-GPD-QPVTALVGDDVVLPCRLFPRMSAENM-NVTWFRAHL-S---P-FVH
RYSNGKDQYEQ----QMPEYQGRTEL-LKDGLTQGNI-ALKIFHVSLSDEGRYSCF--VQ
-D-A--LFYEEA-LLE------L--Q-VA-----ALGSAP-----------------HV-
------SIEDYQDG-GI-R---V--VCRLAGWYPEPKVVWRDLSG-QAVPS-A-------
------S-------------------HT-NSREANGLYRTETSAIIM-----E--NSNR-
IVSC-LVRNTR-LSQ-EKEST---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---FPKV--N----------------P----WMV-SLGVT-LVV-----LLGSFALS--
V-----YLFRIKGKLNGLSAM--------TWR--NRQLRM-RLESGREQEIGGGSN----
--------R-RREREMER-----------ETRG---------------------------
------------------------------------------------------------
---------------------S--------------------------------------
--------GFLAHLQW-R------------------C-SDSPPANVT---L--D-PDTAY
PWFV----------LL-----GDGKRVRWTWT----R--QP-R------------PDT--
LERFDYVPCVL-----------GSEGFT---SGRHY---WE-VE-V--EV---GGGRWAM
GVARESVS-R--K-GE--------------------------------------------
---------------ISLSPKGGIWAVG-Q--W--------GDQFQALTDP-V-----TP
---------------------------------LPLS-PPS---RIQVCLDCDRGQVTFI
DAGTEAP--IFTFPPGSL------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------HMEM-PSSA-----D-----SWLPRCLF-----T
LVFFQLPA-------------------------------------------QG-------
--------S-GDTSKFHLVPLGGTAELICPVPLWPDTVPK-EVRWLRPSHAR-SSQ-AVH
VFLNGTDRDED----LMPEYKGRTAL-VRDA-QEGSF-ILHIRNVTLEDRGQYLCR--VL
-V-G--TRSREG-PVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-Q---L--VCRSMGWFPKPWVEWRDPKG-KVLLSLS-------
--------------------------EA-HSLDETGLFQTAVSSRVR-----D--STLG-
NVSC-TVRNEV-VGQ-EKTTA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
L---S-----S---------------------SA-VALATI-LPI-----LGLLITLG--
I-----WLIWKQRKSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PERFDFVVSVL-----------GSEY FT---AGC HY---WE-VY-V------GEKTKWIL
GVCSDSVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEFEALTSPQT------S
---------------------------------FRLKEPPK---CVGVFLDYEAGVISFY
NVTDKSH--MYTFTHSF--S-SPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEESI
VPNQ---------------------------------------------------EGKG-
-HANGDVSLKVNPS---LLPAQGVEF--FPLK---DI---WPSDLGPALQELKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFGALRKMV-GFL-----RSF-----LSRCLI-----S
LLILQMTV-------------------------------------------CVSEQ-FKV
--------L-GPT-GPIVAILDTDVTLPCRLSPLMNAEHM-DIRWLRSQF-Y---E-AVF
VFQNGREQVGE----QLVEYMGRTEF-ISDFIKEGRV-AVKIYNVKMSDNGEYQCI--FQ
-E-G--DAYEKA-VFE------V--K-VA-----SLGSAP-----------------RF-
------HLEGYEDG-GI-R---L--VCSADGWFPQPQVQCRDNRG-GKLSS-L-------
------S-------------------ET-QAQDEAGFFHAKTVIVVQ-----D--SSVR-
NISC-SIYNLL-LGQ-GKVS----T---IDIS-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKT--S----------------P----WKK-ALIGI-IPV-----MVIFLGIS--
I-----FFILKERKK-TKKLL--------QEKEEEQKYKDNL------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------RTELAWR-----KAHIYAVNVT---L--D-PASAH
PGLV----------LS-----RNGKVMRVKNA----------------------------
VKSAEETFSVL-----------GWGPIT---SGRCY---WE-VK-V--EMEAQNKATWHL
GICREGAS-W--S-GL--------------------------------------------
---------------FRESPEMKFWAVG-C--S--------DGIFRPMTDE-C-----VL
--------------------------------SPSLGKPPE---QIGIFLDCEAGDVSFY
NMTDGSH--IYNFPPASF-S-SPVCPYFSIQT-LNT-------SFTIC-GVS-DRPESIP
APSL----E------------------------TP--------GTAQEQEKFLGDKNKAP
-EDKSTTRQSFSAS---L------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPA-------SLTRS------LVFLMHLLL--
---LQPGE------------------------------------------LN-SE--VKV
--------L-GPE-YPVLALVGEEVEFPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSIVPSDEGTYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLSP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GV
F---SPGA--P----------------P----WKG-ALVGA-LAA----LLAVLAALA--
L-----GFLRLRRRCQEKLKK--------EAEK-REG---KLTAELE-------------
------------------KLQKEL----DWRRAEGQ-----A--E---ILASHP----PG
E-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------G---I--Q-AASN-
-------------------------STTTL---NA-------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------VMDFP
---V-------------------SLDSCQRV-------RLPSS------LSFLTHLLL--
--LLQPRE------------------------------------------MH-SEE-FRV
--------V-GHG-EPILAHVGDEVEFSCHLSPYRDAEHM-EIRWFRSRT-S---D-VVH
LYRERQEFYGQ----QMAQFQNRTEL-VTDEIADGSV-TLRLHPVVPADEGPYGCR--FL
-S-S--DFTGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKQG-GI-Q---L--RCSSSGWYPKPQSQWTDHQG-RCLPP-E-------
------T-------------------EV-IVKDAQGLFSLETSVVVQ-----G--GAHS-
NVSC-SIQNPL-LGQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGT--S----------------P----WKR-AFLGT-LVG-PLLVLALLPTLA--
L-----YFFRRQRRSRXXXXX--------XXXX-XXX---X-XXXXX---X---------
-----------------XPSQATS----DWRRAEGQ-----AEWR---AAQQHA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PGSAH
PSLE----------VS-----EDGKSVSSR---RMAP--GS-A------------AGD--
PQRFSEQMCVL-----------SRERFS---TGRHY---WE-VH-V------GRRSRWFL
GACLAEVP-R--A-GQ--------------------------------------------
---------------ARLSPAGGYWVMGLW--N--------GCEYFVLDPH-R------I
--------------------------------ALTMRVPPR---CVGIFLDCEAGKLSFF
NVSNGSH--IFTFTDTF--S-GALCAYFRPRAHDGS---EHPDPLTIR-PLP-VREKRVP
EEE------DSDTWLQ----------------------------PY-EPS----------
-----DPALA-------MW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTKT-CFQD-AFLPSC------------F--II
LIFLQLLPTVVHG--------------------------------------NGNVT-FDV
--------I-GPN-EPILAIVGKGADLPCHLSPNISAKDM-ELRWYRDKF-S---P-AVY
VYERGKNVSGE----QMEEYRGRTTF-LIDHIANGTA-AVRIHDVTVFDNGTYHCY--FQ
-E-G--TYHKEA-TLW------L--K-VA-----GLGSQP-----------------RI-
------RLRDDKDK-GA-Q---A--ECTSAGWYPRPRVKWRDFRG-KVLPS-V-------
------T-------------------NL-SVSATSGLFAVISNVKIT-----D--RVTE-
GLFC-FIVNPL-LPE-K-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-VLLDLPV-------------------------------------------GGKAD-FEV
--------F-GPR-EPVLAKVGEDADLPCYLYPNISAEDM-ELRWYRDQP-S---P-AVH
VHRKGKDVPEE----QMALYQGRTTF-LKDGVAQGRA-SVRIHNVTTFDNGTFHCQ--FN
-D-G--TMSAEA-TLW------L--R-VA-----GLGSEP-----------------RI-
------QVQVDQDG-VV-R---A--QCTSAGWYPEPQVEWRDFQG-QMLPS-E-------
------T-------------------NI-SISPTTGLWAVASSLTVP-----S--KAVG-
GMAC-SISSPL-LTE-KKVS----R---HHLP-GS-------------------------
------------------------------------------------------------
------------------------------------------------------------
A---LCR--------------------P--SPWVA-QDAIL-EAV-----LA--------
T-----LSMGKIF-HCWAAAQ--------ERPRTKKR---------E-------------
------------------------------------------------------------
-------------------------PS-------S-------------------------
------------------------------------------------------------
------SERVQAQCR-----------------------WTLHPVSPS---L--D-PDTAS
SKLL----------LF-----DDRKSVMRLPF----D--LE-L------------PDD--
PSRFDLDPCVL-----------GRERFS---SGRHY---WE-VE-V------GRREAWVL
GVCVESLN-R--K-GR--------------------------------------------
---------------VAKAPQHGVWAVE-L--S--------KKEYWALTYP-R-----VR
---------------------------------LQLPQPLH---RVGILLDCDAGRVSFY
SVDDRRL--ICTFSGLSR-S-VPLRPFFCLWTHDSS-------PLTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------APRTFF-----LLDSF-L-----
FLLLSVFA-------------------------------------------QLSAQ-FTV
--------V-GPA-APVLVMVGENATLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVL
VYKGGQERTEE----QMEEYRGRTTF-VSNDISQGRV-ALIIHNVTAHENGIYHCY--FQ
-E-G--RSYDQA-IVR------L--M-VA-----GLGSMP-----------------LI-
------EMKGYEDS-GI-W---L--ECTSVGWFPQPHAVWRDPAG-EVMPTLE-------
--------------------------EA-HTVEDDGLFTVTVSVIIR-----D--PSVR-
NVSC-SVTNTL-LSE-EKETV-------MFIP-XXXXX-------XXXXXXXXXXX----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------X-XXXXXXX-----XXX--X
----------------X-----------------XXXXX---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------XXX--X------------------------------XX-X----X----X-X-X
-X------------X------X-X-X--X---X-X-------X-X-X-X--X-X-X----
X-X-X--P-L---------------------L--L----R---N--------S--F-W--
A-----------------------------------------------------------
--------------------------VSFY-----------KNEYWTLTPPEW-------
---------------------------------IFPKECLP---AVCIFL-EEDGYISFY
NMSDNSH--IHTFA-CSF-R-GSLRPLFRLWSS---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------M-GFL-----SSL-----LFICLM-----F
LFSLQMPV-------------------------------------------RGTEQ-FVV
--------L-GPT-EPIVALLGTDIILPCRLSPLMSAEHM-EVRWFRSQF-S---E-AVF
VFQKGKEETEE----QLVEYTGRTEL-ISEFITEGRL-AVKIYNVQISDNGKYQCY--FR
-K-G--DVYEQA-SLE------V--K-VA-----GLGSAP-----------------HL-
------RLEGHEDG-GV-K---L--ACMADGWFPQPQVQWRDNRG-GKLSS-L-------
------S-------------------ET-QAQDEAGFFHVKALIVVQ-----E--SSVR-
NVSC-SICNKL-LSQ-EKIS----A---IDIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPKT--S----------------P----WKK-ALSGI-LPV-----VGILLGVS--
I-----FFIMKERKK-VKKLL--------QKNKEEQKAKALQMK-AAP------------
--------------------V---------------------------------------
---------------------QR----------GICGR----------------------
-----------------DSFGRGWEPVRQAT-------------------AQLLLKALIG
-----------------LS------VHAFSCTC--IDLVSLSAVNVT---L--D-PASAR
PGLV----------LS-----RNGKVMRVENA----------------------------
GKSAEETFGVL-----------GREPIT---SGRHY---WE-VK-V--EMEAQNKATWYL
GICREGVS-R--S-GW--------------------------------------------
---------------VRESSEEGFWIIG-C--Y--------DGTFQPIVSK-Q-----SA
--------------------------------APSLGKPPE---QIGIFLDCEAGDVSFY
NMTDGSH--IYNFPRASF-S-GPVRPYFSIQT-LDT-------SFTIC-GVS-DRPESIP
APSL--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWHPQPKIQWSDAKG-QNIPAA--------
--------------------------EAPLVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGA-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSDTDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FVV
--------L-GPT-EPIVALLGTDIILPCRLFPLMSAEHM-EVRWFRSQF-S---E-AVF
VFQKGKEETDE----QLVEYTGRTEL-ISEFISKGSL-SVKIYNVQMSDNGKYQCY--FR
-K-G--DVYEQA-SLE------V--K-VA-----GLGSAP-----------------HL-
------RLEGHEDG-GV-K---L--ACMADGWFPQPQVQWRDNRG-GKLSS-L-------
------S-------------------ET-QAQDEAGFFHVKALIVVQ-----E--SSVR-
NVSC-SICNKL-LSQ-EKIS----A---IDIP-GQFSVLKRMIRV---------------
------------------------------------------------------------
-------------------------------------------GVNG-----T-GGRTIS
F---FPKT--S----------------P----WKK-AL------------------IS--
I-----FFILKERKK-VKKLL--------QENKEEQKAKELGKF-NFPPQLNSACVSPRT
NFRMIHLLFIDKGS---SSHA---------VSSFCF--L--SAWR---KAHIYA----GE
SLLFPRITTSPISGDFLSWLHKRGRKGARMKAEGGCKDSVESAMVSLWDCPTDPRTLHLF
YPLWKRHSGMRKQPSCTVSFAKAFHNTRFSIGSQLLSSSDEGGPCAERNLWQGLIRERLE
PVRQATAQLLLKALKG-LS------VHAFSWTC--IDLVPLSAVNVT---L--D-PASAH
PGLV----------LS-----RNGKDTKVESA----------------------------
RTSAEETFSVL-----------GREPIT---SGRHY---WE-VK-V--EMEAQNKATWHL
GICREGAS-R--S-GW--------------------------------------------
---------------VRESLEEGFWAVG-C--S--------DGIFWPIVSK-Q-----SV
--------------------------------APFLGKPPE---QIGIFLDYEAGDVSFY
NMTDGSH--IYNFPPASF-S-GPVRPYFSIQT-LDT-------SFTIC-GVS-DRPESIP
APSL----E------------------------TP--------GTAQE------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENCCKNS-----LLS---QLT-CLF-------
-VLEQLLT---CVS---------------------------------------TRE-FTV
--------S-GPS-DPIVVAPGGEAVLPCFLSPARSVENVEELRWFRNRF-S---E-AVF
VYRNQQEQKEE----QRAEYAGRTCL-VKDQFHEGKA-AVHIRNVQESDSGIYVCF--FK
-Q-G--VFYDEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------HIQGPEDG-GV-C---V--VCRASGWYPKPQVQWRDSRG-ETLPA-S-------
------S-------------------ET-HTEDAEGVFSMESSLVVR-----D--SSLG-
NVTC-SAFNPI-LDQ-EKAMS-------MVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQT--S----------------P----WML-AFAIA-MPV-----MGLLVLAS--
C-----CFLVKERHARLQLRQ--------EREKLLCE-LEESQEDILK------------
-------------S--TSTLQEELD-----RRKAAY--M--AAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQA------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MLMEPV------ASLYFS-----LPGFLLF-----
FHLLSSFA-------------------------------------------PVSVQ-FNV
--------L-GPA-YPVLAVVGENVMLRCHLSPEKNAEDM-EVRWFRAQF-S---P-AVF
VYKGRRERTDE----QMEQYRGRTTF-VSEAISEGSV-GLIIHNVTAHENGFYCCY--FQ
-E-R--RSYDEA-IVH------L--I-VI-----SLGSKP-----------------VI-
------EMKGLEDG-GI-R---L--ECVSAGWYPKPQAVWRDPHG-KTMPPLE-------
--------------------------ES-YTVSADGLFLVTTAVIIR-----D--HSMR-
NMSC-SVSNTL-LNQ-EKETV-------IFIP-ESFIP----------------------
------------------------------------------------------------
------------------------------------------------------------
------RT--S----------------P----WMV-ALAVI-LPTL--PLL---IAG--S
I-----YLIKKLQLGKKI-LSM--------QKEADNEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----ITQQLQEELRW--------------------RRSLLHAADVV---L--D-PDTAH
PELF----------LS-----EDQRSVRR--GPSR----QS-V------------PDN--
PERFDCRPCVL-----------GLESYS---LGRHF---WE-VD-V------ENVMVWAV
GVCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------ENQYRALSSPEK------I
---------------------------------LPLKERIH---RVGVFLDCEAGDVSFY
NMKDRSH--IYTCPRSPF-S-GPLRPFFRLGSDDSP-------L-YIC-PSF-RGAQGVT
VPE--------GGLVLY--RAETHHNHQF----PG--------LRAR-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKLK--SS---SFS--------GYC------VG
FLLLQ-VM------------------------------------------TSTSEK-WTV
--------T-IPT-AHLVAIVGGQTELHCQLSPPQSAKYM-EVSWFKGDH-S---K-LVH
LYRDGHEVKGE----AAPEYVDRTEF-VKEAIGEGKV-ALRLHNIRVSDNGTYQCS--FK
-D-S--NFSSVA-SMD------L--S-VA-----ATSLGI-----------------QI-
------LVHPPNTK-GL-L---V--ECNTGGWFPQPQMEWRDSRG-EIIPP-T-------
------S-------------------IS-HSQDTEKLFHMKMTLLLK-----Q--SSHR-
NVTC-CLRNPV-TGQ-EERTS-------IVLS-DQLFP-------WNLIWRLILGIILAL
LVL-FIMVPSIDL-YDRL-----------------------------------------Q
DCLRKMRNPIVVGIIIILLS---IGVIASLISYLHHK---------------IRVPASDP
H---FQLD--T--------------------MWL-EDITV-ILCV-LTV-FITMII-S--
F-----IYFRFRGKW--------------DGK----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------L-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRRRITF-VSKDISRGSV-ALVIHNVTTQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-S---L--ECISKGWYPEPLTVWRDPYS-EIVPTLK-------
--------------------------EV-SITDADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFRP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FT---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVK-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLHYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SPDFLKPV-------SLTSS------LVFLMHLLL--
---LSPGE------------------------------------------PN-SE--VKV
--------V-GPE-YPILALVGEEVELPCHLWPQLDAQHM-EIRWFRSHT-S---D-VVH
LYQEQQELPGR----QMEAFRNRTKL-VKDYIAYGSV-ILQLHSVVPSDEGMYGCR--FL
-S-N--NFSGEA-LWE------L--E-VA-----GLGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDTQGLFSLETSVVVR-----E--GAFS-
NVSL-SIQNLL-LNQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---SPGA--S----------------P----WKG-AFVGA-LAA----LLAVLAGLA--
L-----GVLQQRRRCQEKLKK--------EAEK-REG---KLTA----------------
----------------------EL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-AASAH
PSLE----------VS-----EDSKSVSSR---RAPP--GP-G------------LND--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDCEAGKLSFF
NVSDGSH--IFTFHDTF--S-DALCAYFRPRAHDGG---ERPDPLTIC-PLQ-VRGTCVP
EEN------DSDTWLQ----------------------------PY-ESA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKGSPTFP-----PD--------GCLLSL----
--LLLVST---IVS-------------------------------------GEVSS-FSV
--------R-GQT-EPITVLLGAEATLPCQLSPAQSASPM-HIRWYRARL-T---P-AVL
VFHDGQEQGDV----QMPEYRGRTRL-VRDAIATGDV-TLQIQQVQASDDGLYHCQ--VT
-H-G--FTSQEA-VIE------L--R-VK-----GLGSAP-----------------LV-
------RMTGPENN-GI-Q---V--SCSSSGWFPKPRVQWRNNAG-DTLLS-S-------
------S-------------------ES-QTQDGAGLFHVETSLLVT-----D--RAVG-
NVTC-SIQNPL-HDQ-EEVKA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKV-ALACL-LPI-----LLVLFGGT--
S-----LAGWKEHQAKRREVE--------KKSAEQQE-MSQKKEEMKIA-LKKR------
------------GI-----DRGE-------------------------PQNESE------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQL-------------APVR---I--K-HEVTH
QDKP----------GP-----ETE------ESSR--EETAH-P------------SLSSP
--QEDHNIITL-----------YQEGFM---LGRYY---WE-VD-VGDTE------EWTL
GVYELSTQ-D--V-P---------------------------------------------
----------------SRESLRKFRVLE-K--K--------GDEYRALAFCSQAVSLEEP
---------------------------------LLLETRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFAQARF-L-GSLYPYFTRHPVG-L-------SPSHS-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MVGETATLHCHLLPERSAEDM-EVRWFRSQF-S---P-AVF
VYKGRRARAEE----QMEEYRGRTTF-LSRDLSKGGA-ALVIRNVTAQENGVYRCY--FQ
-E-G--RSYDEA-ILR------L--L-VA-----GLGSKP-----------------LI-
------EMKGHEDG-GI-L---L--ECTSGGWYPEPHAVWKDPYG-GVMPALE-------
--------------------------KA-YTVDKDGLFTVTLAVIIR-----D--SSMR-
NTTC-SVNNTL-LGR-EMESV-------IFIP-ESFMP-------RVSAWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T-LPLLILL-----LFG--S
V-----SLIKKLHRKKKI-LSA--------EKEREHEEKEATHKKLM-------------
------------------------------------------------KECME-------
------------------------------------------------------------
-----------KEEER--------------------------------------------
----QTKEQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDLRSVWR--EASR----QS-V------------PDH--
PERFDCRPCVL-----------GRES FS---SGR QY---WE-VE-V------GHAMVWAV
GVCADGVE-R--K-GD--------------------------------------------
---------------ALLLPQNGFWTLERF-----------GHQYRALSSPER------T
---------------------------------LPLGERLE---RVAVFLDCEAGDVSFY
NTRDRSH--IYTCPRSTF-P-GPLRPFFRLGSDDGP-------L-SIC-PVF-TGARGAT
VPE--------DGLILHNPGTPRRGAS---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDMSRGSV-ALVIHNVTAQQNGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAREDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPTLK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SVAVI-LALFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------RW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVAIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-MPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQ--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------C-----RWQHL-LH--FY
SFLCVLSL-------------------------------------------YLPAS-LTV
--------I-GPS-HPILVRVGEDVELTCYLSPKVNAQNM-EVRWVRSHC-Y---P-AVQ
VYVDGDHVAGE----QMVEYRGRTAL-VGDAIHEGRL-TLQIHGARTSDDGQYRCL--FE
-I-D--DVYQEA-SMD------L--K-VV-----GVGSSP-----------------LI-
------TMEGLKDG-DV-Q---L--MCTSDGWFPQPLVQWMDRQG-EAMPS-F-------
------S-------------------EA-LSQDSRGLFHVETALLVA-----R--SSIV-
NVTC-SISNPL-LGE-RKEHL-------VRIP-T--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L--------------------------------I--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----A-----SWLSGCLI-----P
LVFLRLPA-------------------------------------------HV-SG-L--
--------A-GDAGKFHVAPLGGTAELLCPLSLWPGMVPQ-EVRWLRSPYPQ-RSQ-AVH
VFRDGKDRDED----VMPEYMGRTAL-VRDA-QEGSV-TLQILDVRLEDGGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
V---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QS-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---SGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RENEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYDAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEERT
VPKP---------------------------------------------------EGKG-
-YANGDMSLKVNSS---LLPRKAPEL-----K---DIILSLPSDLGPALQGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MVLQVIF-HVGTTGKD--------TQGQTFLAEVRSSVTILDFALGEVEVS----
----MLNPKASSGPQCLTHTFWCLLI----------------------------------
------------------------HSTDEMA------SSL----------AFLLLSFHVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPP-GPILAMVGEDADLPCHLVPTMSAETM-ELRWVSSSL-R---Q-VVS
VYADGKEVEDR----QSAEYRGRTSI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKGYEAG-GI-H---L--ECRSAGWYPQPQIQWSDATG-ENIPAV--------
--------------------------EAPVAADGAGLYAVAASVTMR-----G--SSGE-
RVSC-IIRNSL-LGL-EKTAS-------ISVA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WMA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEIIAL---------SRETEREREMKELGYATTK-------------
----------------QEIS---------LRETLQE-E---LKWR---KIRYLA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SS--------------------AYHEWKMALFKPADVI---L--D-PDTAN
PILL----------VS-----EDQRSVQRAEE----R--QD-L------------PDN--
PERFDWHFCVL-----------GCGS FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSRNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LTLRERPT---KVGVFLDCETGDVSFY
NAVDGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KVESSP-
YP--D--L-----------------------IAPD--------HPLETPVA------PSL
ANQSGEPQAEETSL---LHPAQPGG-DGLPLH--------S-NQAEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SFV----------AFLLLIFRVC
LLLLQ-------------------------------------------LLMPHSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HV-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNNKG-ENIPTV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------R----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWQQQEEKKTQ---------FRKKKREQELREMAWSTMK-------------
----------------QEQS---------TREKERK-H---VVRG---ECSGEK------
----------------------YKNTD---------------------------------
------------------------------------------------------------
----LFLICVS--------------------FLSEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFNWHYCVL-----------GCES FI---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRTLTEP-R-----TN
---------------------------------LKLPKPPT---KVGVFLDYETGDISFY
NAVDGSH--IHTFLDVSF-S-EALYPVFRILTLEPT-------ALTIC-PAA-D----HS
LE--T--PV-----------------------------------------T------PGL
ANESGEPQAEVTFL---CFSLPSSELRASPST--------A-TNHNHKATSTH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVT---------------------------------------TKG-FRV
--------F-GPS-DPVVAAPGREAILPCSVSPAMSVENMEELRWFRTRF-S---Q-AVF
VYRDQEEQKEE----QMIEYSWRTSL-VKDKFHEGKA-AVRIQNVQESDSGIYVCH--FK
-Q-G--HFHEEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSRG-EILPA-S-------
------S-------------------ET-LHEDAEGLITTETSLVLR-----D--SSVR-
NVTC-STFNPV-LGQ-EKAMA-------MVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKT-AFLVI-LTM-----MGLLVLGT--
I-----SLFGWERFVRLKLQK--------EQIHIHCE-KDELQTEKEDA-L---------
------------RT--AKWGYCEWV-----LTRVCS--F--TAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQTW-------------TFT---L--D-PASAH
PTLV----------IS-----QDRMRVTRKDTTV--C-----------------------
---LDDLFSVL-----------GTKGIS---SGRYY---WE-VK-LENRE-GS---KWIL
GVCREGVE-R--K-GF--------------------------------------------
---------------YFESPEKGFWTVG-Q--S--------SSGYWAYVDSGR-----DS
---------------------------------LSIRQAPE---SVGVFVDYDKRNISFY
NMSDMSH--LFSFHEASF-S-GTLLPYFQLKCGN-V-------SMTVN-SMA-CVSEGQE
GEEG----RKGRKRSRKGRKRRKGRRPKKGKGLAL--------LPLKESLSPTG-EGLVP
GSCVVVSPSGEESP---FLQDARDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------M-NEN-GKFPGLP--SSQLSCLRPFA-SAAHA-SLSSVCCGW-T---T-WAH
PGHDGKEVEDR----QSAAYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-ENIPAV--------
--------------------------EAPVFADGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTTS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQREEKKTL---------FTKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQYTI------
----------------------C-------------------------------------
------------------------------------------------------------
---------K--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----MQIA--R----------------K----WKT-VRVQR-WHH-----C---REYS--
S-----YFLRQQQKEKIAL---------SRETEREREMREMGYAATK-------------
----------------QEIS---------LRG----------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------IQTDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PEGFEWRYCVL---------------------GRHY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYQ--------------
--------------------------------------------KVGIFLDYETGEISFY
NATDGSH--IYTFLHASF-S-EPLYPVFRILILEPT-------ALTIC-PTP-KEVESSP
D---P--DL----------------------M-PD--------HSLETPVT------PGL
ANESGERQAEVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GPIVAPLGGVVELSCYLSPSQNAEHM-EVRWFRNRY-T---Q-PVH
LYKDGKDLHGE----TIFQYVERTQL-LKEDIGKGKV-TLRISNISIDDDGPYHCF--FK
-D-G--DFYEEA-ITE------V--K-VT-------GLKI-----------------QI-
------LVHPPNTR-GL-L---V--QCNSKGWFPQPQMEWRDSRG-EIIPP-A-------
------S-------------------KS-HSQDTNKLFDMKMTLLLR-----H---SQR-
NVTC-YLQNPV-TGQ-EEMTS-------IVLS-GKTC-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVT---------------------------------------TKG-FWV
--------F-GPS-DPVVAAPGREAILPCSVFPAMSVENMEELRWFRNRF-S---Q-AVF
VYRDQEEQKEE----QMIEYSWRTSL-VKDQFHEGKA-AVRIQNVQESDSGIYVCH--FK
-H-G--HFREEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSRG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTENSLVVR-----D--SSVR-
NVTC-STFNPI-LGQ-EKAMA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKT-AFVVI-LTM-----MGLLVLGT--
I-----SLFGWERFVRLKLQK--------EQIHIHCE-KDKAQTEKEDA-L---------
------------RT--AKWGYCEWV-----LTRVCS--F--TAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EHFQTW-------------TFT---L--D-PASAH
PTLV----------IS-----QDRMRVTRKDTTV--C-----------------------
---LDDLFSVL-----------GTKGIS---SGRYY---WE-VK-LANGE-GS---KWIL
GVCREGVE-R--K-GF--------------------------------------------
---------------YFESPEKGFWTVG-Q--S--------SSGYWAYVDSGR-----DS
---------------------------------LSIRQAPQ---SVGVFVDYDERNISFY
NMSDKSH--LFSFHEASF-S-GTLLPYFQLKSGN-V-------SMTVS-SMA-CVSEGQE
GEEG----EKGEEQEEGK------------------------------------------
--------EEEESQ---FLQRVRDTL--FP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------KMVDFPGGL-----PA--------GFLFPL----
-LLLQLS--------------------------------------------TAASG-LSV
--------E-GQA-EPVVAPLGADASLPCRLAPEQSMAHM-SIRWYRGQP-S---R-AVL
VFRQGQEQVGE----QMLEYRGRAEL-LRDAVGSGSV-ALLLRRVRASDDGLYHCR--FE
-D-G--DVSQEA-LVQ------L--N-VV-----GLGSAP-----------------QV-
------HMTGPKEG-GI-Q---V--LCSSSGWFPRPTLQWTDTTG-RKLPS-L-------
------P-------------------ES-HTQQEDGLFHVDASLVVT-----D--SSLG-
NLTC-SIQNPL-SGQ-EKTST-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--S----------------A----WKL-ALAGT-LPI-----LGLLLIGI--
S-----YAGWREHQNKEKQIK--------EKEKEDNE-AKHMSREKELV-LQAK------
------------GE-----LEAELE-----WRRKLY--NQ--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EHFKP-------------APVI---P--K-HQMIQ
SNNS----------DP-----ESK------ENCR--DETQE-L------------PLSDK
--QGDGNLITL-----------GQEGFL---WKRHY---WE-VD-VEKVE------EWTV
GICEVPSD-G--P-ES--------------------------------------------
---------------FEEPSRKTFRVLV-K--K--------GDEYKALACCSKNIFLEKH
---------------------------------VSVEKRPC---KIMLFLDIEDSDISFY
NMTDGSH--IFSFNQSKF-S-GSLYPYFKHGSME-L-------SPTSK-C----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------MGA-PC----------SALKEMAGFPGLF-----PA------G--VL-P-----
AL-LWVSM---WGS--------------------------------------PVSG-FSV
--------M-GPA-QPIKVSLGADATLPCQLSPEQSAAHM-QIRWYRTQL-S---P-VVL
MYQNGQEQDGE----QMLEYRGRTEL-VEDSISRGAV-ALLIQHVRASDDGQYWCH--FN
-D-G--HISREA-VVE------L--Y-VI-----GLGSAP-----------------HV-
------RMMGPEDH-GI-Q---V--LCSSGGWFPKPWVQWRDTAG-EKLLS-L-------
------S-------------------ES-QTQDGDGLFHVEASLVVT-----D--SSLG-
NVTC-SIQNPV-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRT--S----------------P----WKT-ALAGT-LPV-----LLLLLIGI--
S-----YTGWREHRAKTREVE--------KRKEASHQ-RDKVAKEKEEA-HSIK------
------------RK-----LEEDLE-----QRKALY--NK--DWK---KALIYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFEH-------------VLVI---E--N-HENIH
QNNS----------DF-----RK--------------E-PQ-A------------VLCKK
--QGGGNLLKL-----------DQKGFT---KGRHY---WE-VD-IEDTD------EWTL
GIYEEPTE-K--S-E---------------------------------------------
--------------------KMKFNVLE-K--R--------GCKYRALTCSRQDISHKQS
---------------------------------LLIEKCPQ---KIVIFLDYEDSDISFY
DMTDETH--IFSFSHANF-S-GSVYPYFKLKSME-F-------SPSA-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVA---------------------PGLTACLVAL
ALLQLH------------------------------------------------------
------------------------------------------------------------
-------A------------------------------------------LRAAAR-FDV
--------I-GPT-EPVLVATGNDAELPCRLSPNVSAAHM-ELGWFREAP-S---Q-PML
LHRDPQGRARD----PAPEFRGRVTL-VADGIAEGLA-AARLHKVRTADDGDYRCF--FR
-D-AA--SSGEA-TVR------L--R-VA-----ALGSDP-----------------HI-
------SMEVLESG-EI-R---L--ECTSVGWYPEPQVWWRTPTG-EKFLS-M-------
------S-------------------ES-KSPDQEGLFTVAASVIIR-----D--TSVE-
NVSC-CVRNLL-LGQ-QKKVG-------ISVA-APD------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WQV-AVAVV-LMV-----LGLLTIGS--
I-----VFIWRLYKDRFREKK--------SDFSSK-------------------------
-------------------------------EKLLE-EL---KSK---KASLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VNVT---L--D-PDTAH
PHLF----------LY-----ADSKSVRLEDS----R--QK-L------------PEK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAV
GVCRENVI-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGSPR---RVGIFLDYDSGDISFY
NMSNGSH--IYTFPDVSF-S-GPLRPFFCLWSCG-------KKPLTIC-SVA-NGPEEVT
VIAD----A------------------------QA--------LSKDIPLS---PTREEP
ASGDADT---LHSK---LIPLQSSQR--VA------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYNLSGA---VASFLFIL
LTMKQSEDFRVIGPAHP-ILAGVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPV-FVHR
DGVEVTEMQMEEYRGWVEWIEN-GIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSL
LLKVAGLGSAPSIHME---------GP---GE---------------------------S
GVQLVCTARGWF----------PEPQ---VY---WEDIRGEKL-----------------
-LAVSEHRIQDKD--------------------------------G------------LF
YAEATLVVRNAS----------------------------------AESVSCLVHN----
PVLTEEKG------------------------------SVI--SLPEK-LQTELAS-LKV
--------N-GPS-QPILVRVGEDIQLTCYLSPKANAQSM-EVRWDRSHR-Y---P-AVH
VYMDGDHVAGE----QMAEYRGRTVL-VSDAIDEGRL-TLQILSARPSDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----SLGSSP-----------------LI-
------TVEGQEDG-EM-Q---P--MCSSDGWFPQPHVPWRDMEG-KTIPSSS-------
--------------------------QA-LTQGSHGLFHVQTLLRVT-----N--ISAV-
DVTC-SISIPF-LGE-EKIAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------WKTLLVWGL-LLAVA-------------
V-----GLPRKRS-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------LKPFL-SKKG-GGKEPG-----SLLV------HG
LLSLPPSP-------------------------------------------ACHKS-FKV
--------I-GPD-RPIRALVGEDALLPCHLSPQMSAERM-EVRWFRSMF-S---A-VVH
LYRDGRDQADQ----QIAQYKNRTKL-LKDGIANGSV-SLRIYNITPSDEGTYGCF--FQ
-S-L--SFYKEA-ILE------L--Q-VT-----GLGTSP-----------------HL-
------SVDGYRDG-GI-H---V--VCQSAGWYPEPQVLWRDARG-QQLAP-A-------
------M-------------------EE-ISRQADGLFNVHSAAVVT-----D--ASTQ-
NLSC-SVSNPR-LGQ-GRTA----A---LHIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------V
F---LPRI--S----------------P----SQV-ALAVA-LAG-----VSCLLALA--
G-----YAFWKQHREKESLRA--------E-LERDRE-----------------------
---------------------KSL---AELG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KCRVCLDW-QR-----S-----WSQEEMRVCPGQAVTVI---L--D-PDTAH
PSLG----------IS-----ESRRSVRWGLR-------QD-V------------SDN--
PQRFDCETCVL-----------GSGGFT---SGRHY---WE-VE-V--GG----GRAWAI
GGAREAVR-R--K-GW--------------------------------------------
---------------ISFSPEEGIWAVD-Q--C--------GSHYRARTTP-D-----TL
---------------------------------LPLNEGPH---RIGVYLDYDQGLVSFY
HPHMEVP--IYTFTS-SF-S-GTLYPFF--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDYPGYSLPGV---AASLLFLL
LTVKHPGRVPSSLAGTP-CGA-----------------KIHNTTRWCSNS----------
-GCRGPGL------------------------ELGFPTPALDSSYL--------------
--------VAHLLGTE---------GA---GE---------------------------G
GIQLVCTSQGWF----------PEPE---VY---WEATWGEEL-----------------
-LSFSQNHVLGED--------------------------------G------------LF
YVEDTLVVRNDT----------------------------------SETYSCFIYN----
RGLEEAKE------------------------------AVI--ALPEK-LQTELAS-SRV
--------I-GPS-QPILVRVGENIEITCHLSPEADAQSM-EVRWVRSHY-Y---P-AVH
VHVGGAHSAGE----QMAEYRGRTVV-MRDAVHEGKL-TLRIHDARTSDDGRYRCL--FG
-K---DGVYQEA-RVD------V--Q-VM-----AVGSTP-----------------RI-
------TQEVLKDG-GL-Q---L--RCTSDGWFPRPQVQWRDRGG-RAVPSFS-------
--------------------------EA-FHQGSQGLFQVETLLQVT-----N--GSVV-
NMTC-SISLPW--GE-EKAAW-------FSLS-DSRI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMALPVLLL-PLAMA-------------
V-----DLLKAKHPRKGKNTT--------A-ISNISGVT---------------------
---------------------------------E----------A---RQG---------
-LPS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-K----
--------------RL--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

--------------------------------------AYISECFLFGA---VASFLFVL
LSMKPSADFRVIGPSHP-ILARVGEDALLTCQLLPKKTAMPTKVTWYRLDSSTPV-FTLL
DGSEVTEKQLEEYRGRVEWIED-NIAEGRVSLKIYNTQPSDDGQYWCRFQEGDYYVETSL
QLKVASL-SAPRVHMI---------GP---ED---------------------------G
GIWILCSSGGWF----------PRPR---LQ---WSGEVGIKL-----------------
-MALSETLTQDGD--------------------------------G------------LF
HVEASLVVTGRS----------------------------------LDNVICSIQN----
PVSHQENM------------------------------SVI--FLPNK-LQTELAS-LKV
--------I-GPS-QPILVRFGEDVNLTCSLSPKANAQDM-EVRWVKGHY-Y---P-AVY
VYMNGDHVAGE----QMEKYRGRTTL-VSDSINEGTV-TLQIHKARTSDDGQYRCL--FE
-K---DGVYQEA-SLD------L--K-IV-----GMGSSP-----------------VI-
------TMKKAKDG-EV-Q---L--TCTSDGWFPRPLVQWKDVEG-KTIQSFS-------
--------------------------EV-LTEGSHGLFQVETHLLVT-----N--SSVV-
NVTC-SISNPL-LSE-EKATN-------FSFS-GWCH-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------TEE-FTV
--------A-GLT-RPVLAPLGGNLELSCQVFPPQNAQHM-EIRWFRNRY-T---Q-PVH
LYRNGKDLHGE----TISKYVERTEL-LKDDIGKGKV-TLRIFNVTADDDGPYHCV--FK
-D-G--KFYEEH-IAE------V--K-VT-----VTSSDI-----------------QI-
------FMHPPNSK-GV-M---L--ECHSAGWFPLPHMEWRDSKG-EVIPE-I-------
------S-------------------KS-HSQDINKLFNMTMVLLIK-----A--SSHR-
NVTC-CLRNLL-THQ-EESIS-------IILS-GKICL-------CSSCFIKQSQSRSSK
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARA-HPGD-ATLPSI----LVS---FIF--LQ
LLTSG----------------------------------------------NGKSD-FLV
--------L-GPP-HPLLAIVGQDKELPCKLSLNISAEGM-ELRWYRDKP-S---S-VVH
VYKNGEDVYDE----QMAEYKGRTSF-NGSHVARGEA-AVKIHNVTVFDNGTYHCV--FK
-E-Y--TSHSQA-TLW------L--K-VA-----GRGSSP-----------------RI-
------RVTDTQDK-GI-R---A--ECTSAGWYPEPKVEWLDLKG-QPVSA-E-------
------S-------------------HF-SVSASTGLVALLSIVTPQ-----D--AAVG-
GLTC-SISNPL-L PE-KVME----T---YLL--A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---SRRP--L----------------S--TESGP-ALPLI-LTA-----LGLVSAAI--
A-----CAFGKCHKEEHKTNQ--------EEEDPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AR-D-------------------EAGLFHVS LS---L--D-PETAS
PKLM----------VS-----EDQKSVKRLLF----D--QD-V------------YPS--
SRRFNQDPCIL-----------AQER FE---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLV-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKKLQALSYP-R-----TC
---------------------------------LSPPEPLR---RVGILLDFEAGQISFY
NSTNDSL--IYVFSGFSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-TETKEDT
ESSG----D------------------------PG--------LPGDS------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------FKARTY------LVSCISI--FI
LCLIKPQL-------------------------------------------IILGK-FQV
--------I-GPK-SPVIAVLGENVELSCHLSPSMDVQKM-EVRYHRNNP-F---G-LVY
LYNNFQDHVEQ----GMPQYQGRTEF-LRDNINKGHV-ALKILSIQLSDGGEYSCS--FE
-N-S--TYINAA-QFQ------V--L-VT-----GSGIAP-----------------HI-
------HIDHAETK-GL-K---L--TCTSTGWYPEPEVQWRDLQG-QHFSP-A-------
------S-------------------EK-KTPERSGLFHVESSIILD-----E--SSER-
NVAC-YIRNPV-LSV-EKEV----H---ISVT-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPRV--S----------------P----WPI-VIPVMVVLL-----IIIGIIC---
V-----LLMRARKSKVKSD----------M------------------------------
-------------------NKIE------IK-----------------------------
------------------------------------------------------------
---------------------K--------------------------------------
--------KMIKEIHW-RS------------------GTTLHTEDIK---L--D-RTTAH
AYLS----------VS-----DDEKRVTSVPE----K--QN-V------------PED--
P-RFDTLVAVL-----------GQNSFS---GGQHY---WE-VE-V--AG--------TL
GLCWDSVS-R--KAQY--------------------------------------------
---------------ISAHPEHGFWTLC-L--K--------SGVYQALSTP-R-----YI
---------------------------------LNIPEPLS---TVG-FLNYEEGLIFFY
NVTEFTI--LYTFKS-KF-T-KPMKPFL--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------SD-FRV
--------L-GPP-DPLLAILGQDKELPCKLSPNISAEGM-ELRWYRDQP-S---P-AVH
VHKNGEDMYEE----QMVEYRGRTTF-IGNHMVRGEA-AVRIRNVTMFDNGTYHCG--FK
-E-H--TSRSQA-TLW------L--K-VA-----GLGSSP-----------------RI-
------HVTYTQDK-SI-W---A--ECTSTGWFPEPSVQWLDLKG-QPVPA-E-------
------T-------------------HF-SAIASTGLLTVVSIVTTQ-----D--RAVE-
GLTC-SISNPL-LPE-KKVA----E---TYLP-GEPWVPG--------------------
------------------------------------------------------------
---------------------------------------------MF-----G-ESCGAP
L---FRRP--L----------------S--TERGP-VLPLI-LAA-----LGLVTAAI--
A-----CAFGRSHKEDKSEEE--------EEVSPG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AS-A-------------------DVEPFHAS LS---L--D-PETAS
PKLM----------VS-----EDQKSVKRLLF----D--QD-L------------SPS--
SKRFDQDPCIL-----------AQER FD---AG RHY---WE-VE-V------GDRRAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPQHGLWALE-F--Y--------KKRLQALSYP-R-----TH
---------------------------------LSLPQPLC---RVGIFLDFEAGEISFH
NAANGSL--IYMFSGLSF-S-GPLQPFFCLWTHDPR-------PLTIC-SVV-RETEEDT
GSSE----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---NRQ------------------------V------SCLL---------AFL-----LQ
LLVLQLPT------------------------------------------LDS-AP-FHV
--------T-APQ-EPVLALVGSDVELTCLFSTNESAEHVEELRWFRQTR-S---P-AVL
LYRAGQEQEDQ----QMTEYRGRATL-VTDGLPDGRA-TLLIRGVRVSDQGEYRCS--FK
-D-ND--NSEEA-SAH------L--K-VA-----ALGSDP-----------------HI-
------SMEVKENG-QI-Q---L--ECTSSGWFPEPEAQWRTPSG-GRLPF-T-------
------A-------------------ES-RNHDEEGLFTVAASVIIT-----D--SSIK-
NVSC-CIQNHL-LGQ-EKEVE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAII-ILA-----LGFLTIGS--
V-----FFTWRLYKERSRGKK--------SEFGSK-------------------------
-------------------------------GCKKT--------------ALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVCLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYESGDISFY
NMSDGTL--IYTFPSTSF-S-GPLRPFFCLWSSG-------KKPLTIC-PTA-NGPGKIT
VIAN----A------------------------QD-----------SIPLS---PLGEGS
ASGETDT---LHSK---LIPFSPSQV--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
ALVLSLL-------------------------------------------RLVSGQ-WQV
--------I-GLD-RPAQALVGEDVLFSCFLSPETNAEAM-EVRFFKNKL-Y---A-VVH
QYRDGKDQEHM----KMPDYRGRTVF-FKDFLAKGHV-SLRLQKVTPLDAGLYGCW--FR
SQ----TYEQEA-IWE------L--Q-VL-----EMGSTP-----------------LI-
------SIKGFVDG-GI-R---L--HCQSSGWFPQPTVKWKGST---ALPSDS-------
---------------------------K-VNVDGHGLFDVETSLIIQ-----E--D-SG-
SISC-CIQYPD-QSL-EVESR-------VWIK-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------S----WRL-PSILLIFLV---FGLCAAFIGL--
-----RISFSKSQGK----IQ--------TKV----------------------------
------------------------------------------HYE---GMDR--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAEWREARKHAVEVT---L--D-MDTAH
PQLY----------IS-----D-MKAISCRSH----P--QE-V------------PDS--
EKRFK-RKCVV-----------ASQGFR---QGKHY---WE-VD-V------GFHKRWYL
GVCRDDVE-R--K--VC-------------------------------------------
---------------ISLCPTNGYWVFGQW--G--------HQQYFTFNPS-K-----FS
---------------------------------LFLRTPPT---RVGIFLDYEDGAISFF
NINDQSL--IY-KMEHQFEG-V-LRPFFE--IYE-G---ETVNPIYIC-PVS-LR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVPT
------------------------------N------SCLL---------VCL-----LT
LTVLQLPT------------------------------------------LDSAAP-FDV
--------T-APQ-EPVLALVGSDAELTCGFSPNASSEYM-ELLWFRQTR-S---T-AVL
LYRDGQEQEGQ----QMTEYRGRATL-ATAGLLDGRA-TLLIRDVRVSDQGEYRCL--FK
-D-ND--DFEEA-AVY------L--K-VA-----AVGSDP-----------------QI-
------SMTVQENG-EM-E---L--ECTSSGWYPEPQVQWRTGNR-EMLPS-T-------
------S-------------------ES-KKHNEEGLFTVAVS MMIR-----D--SSIK-
NMSC-CIQNIL-LGQ-GKEVE-------ISLP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAII-LLA-----LGFLTIGS--
I-----FFTWKLYKERSSLRK--------KEFGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTVLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TS
---------------------------------LRLAGPPR---RVGVFLDYDAGDISFY
NMSNGSL--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-STA-NGPEKVT
VIAN----V------------------------QD-----------DIPLS---PLGEGC
TSGDKDT---LHSK---LIPFSPSQA--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------AQ-LRV
--------E-GPG-HPVTGTVGQDVVLPCHLSPQRDARSL-EVRWIRDHI-S---E-TVH
HYRNGEDLYRE----QMEAYAGRTEL-SRDGLSAGSL-DLRITGLRPSDDGLYICT--VK
-N-T--DAYDEA-IVE------L--E-LS-----ATGADP-----------------HL-
------SLGGYEAG-GV-R---V--LCRSAGWYPLPQLLWRDARG-QHLPS-V-------
------S-------------------QT-HSQDQEGLFEIEGAVIVT-----G--SIEG-
PLSC-VVRSSR-LQQ-ERES----S---LHIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FHNA--Q----------------P----WMV-ALAL-VLVL-----LAVSIGLG--
V-----YLFRKQGKLAAQGWS--------ED-SFSEE-----QA----------------
--------------------AEL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AW-RR-----------------CLLPQNKVKVT---L--D-PHTAH
PELI----------LS-----EDHRSVRWKNG----L--KD-V------------PDT--
DERFDIRLCVL-----------GYEEFR---DGRHW---T------------ESNSWWAV
GVAKASVK-R--K-GL--------------------------------------------
---------------FNMSPEEGIWAVQ-Y--D--------EGQLMSLTSP-R-----TP
---------------------------------LSMSPVPT---RIWVCLDCTQQHVSFI
NADNGVE--IFTFTAANFNK-KPIRPWFLLWTPGIQLCLRDSTPQTLS-PAL-GGSCPSP
DTPV---------------------------------------------SPL--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDITAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWNNTKG-EDIPAV--------
--------------------------KAPVVADGVGLYAIAASVIMR-----G--SSGK-
GISC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKVAL---------SRETEREREMKEIAYAATK-------------
----------------QEIS---------LRGI--------QKWR---KIQ---------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------YMALDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GHEN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TS
---------------------------------LKLPESPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--D-----------------------LVPD--------HSLETPVA------LGL
ANESGEPQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADCS
---TS-------------------LDSSQRA-------SLPGR------LFFFTFFLL--
LLLLQLGE------------------------------------------QN-SEE-FKV
--------V-GPG-EPKLALVGEQVEFSCHLSPYQDAEHM-EILWFRHSI-A---D-VVH
LYPERREPSEL----PLAQFRNRTKL-LKDQLVDGAV-ILQLRGVLPADRGPYGCH--FL
-S-P--SFSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------TLEGFKEG-GV-Q---L--RCSSSGWYPKPQVQWKDHQG-QCLPP-E-------
------T-------------------EL-ILEDAQGLFSLETSVVVR-----R--GTHS-
NVSC-SIQNPL-LVQ-KKEFS-------VQIA-XXXXXXXXXXXXXXXXXXXXXX-----
----------------------XXXXXXXXXXXXXXX-XXXXXXXXXX------------
-------------------------------------------XXXX--XX---XXXXXX
X---XXXX--X----------------X----WR--------------------------
------------------------------RA----------------------------
-----------------------------EG----Q-----AEWR---EAQQYA----VD
L-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----QDLKSVSSRAV---TAETSP-A------------AGQ--
PERFQEQTCVL-----------SSQSFS---TGRHY---WE-VD-V------GRRSRWFL
GACLEAVS-R--S-GR--------------------------------------------
---------------ARLSPAAGYWVLGLW--N--------GCEYFVLEPR-R------L
--------------------------------ALSLRVPPR---RVALFLDCDAGKLSFF
NATDGSH--IFTFTDSF--S-GPLCAYFRPRAHDGG---PHPDPLTIC-PLP-ARGARGP
EEN------ERDFWLQ----------------------------PY-ESL----------
-----EPTLG-------QW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MAASC-----D-----SWLAGCLI-----T
LVFLQLPT-------------------------------------------HLSGP-LT-
--------M-VTPKEYHLAPLGGTAELLCPLPLWPQVAFD-EVRW-------------VH
VFRDGQDREDE----LLPEYRGRTAL-VRDA-REGTV-TLQIRDVRLEDRGPYRCR--IR
-I-G--NLSRED-AVS------L--Q-VA-----VLGSDP-----------------YI-
------HVTGYDAG-WI-Q---L--VCRSAGWFPKPWAEWRDPEG-RKLLSLL-------
--------------------------EV-HSPDEAGLFRTAVASRIR-----D--STLG-
NVSC-TVRNVA-LGQ-ERTTV--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
L---S-----A---------------------SE-VALAAI-LPV-----LGLLITAG--
V-----YLIWKQRQSKDLSN------------SLC-------------------------
-------------------------------------------------SS---------
------------------------------------------------------------
------------------------------------------------------------
-------EKLR--------------------NELSWRRARLHFVAVA---L--D-PDTAH
PKLV----------LS-----EDRRCVRLGDR----K--QP-L------------PDN--
PQRFDFVVSVL-----------GAEYFT---AGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGDEYEALTSPQT------A
---------------------------------LRLKQPPR---CVGVFLDYEAGVIAFY
NVTDKSH--IFSFTDSF--S-GPLRPFFEPCLHDGG---KNTAPLIIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MLYT-GSYT-YFLKIS------YLGNVCL--LL
LE--------F--------------------------------------SVHFHQQ-FYV
--------I-GPR-APVIGLVGEEAVLSCQLSPSMDAQNM-EVKWYRNDP-F---G-LVH
HYSTSQVDMEQ----QMPEYQGRTEF-LKENITKGHV-ALRIRPIQLSDGGEYACF--FE
-S-S--TYYNDA-TFQ------V--L-VT-----VSGRAP-----------------HI-
------HIEPGNKK-DF-K---V--TCMSTGWYPEPEVQWRNHQG-LHLAP-G-------
------S-------------------ET-KTMEGSGLFHVESSLTVD-----K--SSRA-
DVSC-VVRNTI-LNV-EKEVH-------VSLA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSL---------SASLLF-----
-SILSLLA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAMVGENTTLSCHLSPEKSAEHM-EVRWIRTQF-S---P-AVF
VYKGGQERPEE----QMEEYRERTSL-VSDNIGKGHV-ALVVYNITAHEDGTYRCY--FQ
-E-G--RSYDEA-SLR------L--M-VA-----GLGSQP-----------------SI-
------EMKGHEDG-GV-L---L--ECTSEGWFPEPHALWRGTYG-EVLPALT-------
--------------------------DA-YTVEADGLFSVITAVLVK-----D--SSVR-
NMTC-SINNTL-LGQ-EKETV-------IFIP-XXXXX-------X--------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------XXXXX-----VAG--S
I-----CLVRKLHREKEI-LSV--------EKEIEHEEKEIASKGLG-------------
------------------------------------------------KRVWK-------
------------------------------------------------------------
------------------------------------------------------------
-----EIAQLQEELLW--------------------RRTLLNAADVV---L--D-ADTAH
PELF----------LS-----EDARSVRR--GPCR----QS-V------------PDN--
PERFSCRPCVL-----------GQERFA---TGRHY---WE-VE-V------DNVMVWAV
GVCRDSVD-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALCSPEM------I
---------------------------------LPLRERLR---RVAVFLDYEAGDVSFY
NMRDRSH--IYTCPPPAF-S-RPNLAQTKIPP------------------AP-TGPISSS
QNHL-----EKAYHELHHLA--IFCMSTFHNPTLLTRLCFY-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LLLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNAKG-ENIPAV--------
--------------------------EAPVVADGVGLYEVAASVIMR-----G--GSGE-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLAGA--
S-----YFLWRQQKEITAL---------SSEIESEQEMKEMGYAATE-------------
----------------REIS---------LRESLQE-E---LKRK---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGEES--------------------------SSDTNKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------PTMV------RPL----------AFHLLHLPVC
LALVQ-------------------------------------------LLTPCSAE-FAV
--------I-GPP-EPILAMVGEDVELLCHLSPKMSAESM-ELMWLRSGL-R---Q-AVC
AYADGKEG--T----EIAEYRGRTSI-LREDIAEGKA-ALRIHKVRTSDSGTYQCY--FQ
-D-A--DFLAKT-QVE------L--N-VA-------------------------------
------------------------------------------------------------
--------------------------------DGEGLYAVTSSVILE-----G--GSGK-
GVSC-VVRNPL-LSQ-EKTAR-------VSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------AP
F---FSST--K----------------P----WQV-AFGVT-LVA-----LLGLLAGL--
V-----MSWWQQQKRVLAL---------TQEKERERAEKEAAWMKEQ-------------
----------------LEQS---------AKEKLQE-E---LRWT---KKQNMA------
----------------------PGD-----------------------------------
------------------------------------------------------------
--------RSQ--------------------AYAEWKMALYQPADVI---L--D-PETAH
PKLH----------IS-----EDQRSLKRIKK----R--QN-L------------PEN--
PRRFRDLYCVL-----------GRESFT---SGRHF---WE-VE-V------GDRKQWHL
GVCRENVE-R--K-RY--------------------------------------------
---------------VKITPQNGFWTIARL--N--------RSDFRAQTDP-W-----SK
---------------------------------LIIVNPPK---RVGVFLDYERGEVSFY
DAINGSH--IFTFSQTLF-S-CPLWPVFWILSEEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TEPA------ASLHFS-----LPASFL-L----
-PILSLLA-------------------------------------------LVSAQ-FTV
--------K-GPA-DPILTMVGENITLHCHLSPEKNAEDM-EVRWFRTQF-S---P-AVL
VYKGGRERTEE----QMEEYRGRATL-VSKDMSRGSV-ALVIHNVTAQDNGIYRCY--FQ
-E-G--RSYDEA-IMH------L--K-VA-----GLGSQP-----------------FV-
------EMKGHEDG-GI-R---L--ECTSGGWYPEPLAVWRDPYG-KDVPALE-------
--------------------------EA-YTADTDGLFLVTIAVIIR-----D--SSVR-
NMSC-SVNNTL-LGQ-EKETV-------IFIP-EYFTP-------SISPIVVILAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LPILTIL-----MAV--S
M-----CCIKKLQRKKKI-LSE--------EKEVEQEEKEIA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------WQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSR----QS-V------------PDN--
PERFDCQPCVL-----------GRESFT---SGKHY---WE-VE-V------ENVMGWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------ENKYRVLSSPER------I
---------------------------------LPLRERLC---RVGVFLDYEAGDVSFY
NMRDRSH--LYTCPHSAF-A-GPLRPFFRLGSDDSP-------L-FIW-PVL-TGANGVT
VPE--------EGLILHRSQTHHLPQDQLP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TEPA------ASLHFS-----LPASFL-F----
-PILSLLA-------------------------------------------LVSAQ-FTV
--------K-GPA-DPILTMVGENITLHCHLSPEKNAEDM-EVRWFRTQF-S---P-AVL
VYKGGRERTEE----QMEEYRGRATL-VSKDMSRGSV-ALVIHNVTAQDNGIYRCY--FQ
-E-G--RYYDEA-IMR------L--V-VA-----GLGSKP-----------------LV-
------EMKGHEDG-GI-R---L--ECTSGGWYPEPLAVWRDPYR-KVVPALD-------
--------------------------GS-HTADADGLFLVTTAVIIR-----D--RSMR-
NMSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------SISPWVVILPL----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAVLIAP-----IAI--S
I-----YYIKKLHREKII-LLG--------AKEVELEEKEIAQKELY-------------
------------------------------------------------KERAE-------
------------------------------------------------------------
-----------KEKA----H----------------------------------------
-QI---KEQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSH----QS-V------------PDN--
PERFDCRPCVL-----------GRESFT---SGKHY---WE-VD-V------ENMKMWTV
GICRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------ENQCRALSSPER------I
---------------------------------LPLRERLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-A-GPLRPFFRLGSDDSP-------L-FIC-PAL-AGANGVT
VPE--------DGLILHRARTHHHL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------T-GPG-KFVQASVGEDAVFSCSLFPETSAEAM-EVRFFRNQF-H---A-VVH
LYRDGEDWEYM----QMPQYRGRTEL-VKDSIARGHV-SLRLKNITPLDIGLYGCW--FS
SQ----IYDEEA-TWE------L--R-VA-----ALGSVP-----------------LI-
------SIAGYVDG-GI-Q---L--LCLSSGWFPQPTAKWKGPQG-QDLSSDS-------
---------------------------R-ANADRHSLYDVEISIIVQ-----E--N-AG-
SILC-SIHLAE-QSH-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASISLGLLC---VALCVVVIRM--
-----TIVFFKSKGK----IQ--------AEL----------------------------
------------------------------------------DLG---KIHK--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PKLC----------VS-----D-LKTVTHRKA----P--QE-V------------PYS--
KKRFT-SKSVV-----------ASQG FQ---AG KHY---WE-VD-V------GQNVGWSV
GVCRDDVG-R--W-KNN-------------------------------------------
---------------VTLSPNDGYWVLGLT--T--------ERVYFTFNPH-F-----IS
---------------------------------LSPSTPPT---RVGVFLDYEGGTISFF
NINDQSC--I-HILTCQFEG-L-LRPYIKHLIYK-E---KMGTPIFIC-PVS-GS-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AAPHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLHCHLSPEKNAEDM-EVRWFHSQF-S---P-AVF
AYKGGRERTEE----QMEEYQGRVTF-VSKGIGRGSV-ALVIHNVTAQENGIYRCH--FQ
-E-G--RSYDKA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLS--RDPYS-EIVPTLK-------
--------------------------EV-SIADADGLFVVTTAVIIR-----D--KSVR-
NVSC-SIKNTL-LSQ-EKENV-------VFIP-ESFTP-------STSPWMVAFAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SLAVI-LAVFLIF-----MPV--S
I-----CCIKQLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAAHVV---L--D-PDTTH
PELF----------LS-----EDRRSVSP--RPYR-----R-V------------PDN--
PERFDSQPCVL-----------GWESFA---SGKHD---WK-VE-V------ENVMVWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---HVGVFLDYEARDVSFY
NMRDRSH--IYTCPHSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGASGVT
VPD--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MSLAAMAKT-HFQD-TFLPHC------------L--IV
LIFLQLLPSNICR--------------------------------------K--AD-FTV
--------F-GPN-DPILAIVGEDTELLCHVNLNISIENM-ELRWYRDQP-S---P-AVY
VYKKGNDTHEE----QMEEYRARTTF-VGDDVAKGKA-AVRIHNVTALDNGTYHCC--FR
-D-G--KAFSEA-TLW------L--K-VA-----GLGAEP-----------------RI-
------RLRDDTDK-GI-Q---A--ECTSAGWYPEPQAVWTDSRG-NTLPS-E-------
------G-------------------RI-SASASSGLFAVASNVTVR-----D--SAVE-
GLRC-SISNPL-LPE-RKVAE-------IQLP-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---SRKSQST----------------V----WKI-VLPLM-LIA-----LGLVITGV--
I-----CVFWKRQKEKNRRLL--------E-DESKLS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------RLQ----------------------------------AS---H--Q-PPNEQ
LQEE----------LS--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
----------------------VSLDSLYQV-------PLPSH------LFLLTHFLL--
--LFPSGR------------------------------------------L-DSEQ-LKV
--------V-GPG-ESILARVGEEIEFSCHLWPYQDAEHM-EILWFRSRA-T---D-VVH
LYQEQQELFGQ----QMMEFQNRTKL-IRDEIRDGHV-VLLLYNVVPSDEGHYGCR--FL
-S-N--NFTEEA-LWE------L--E-VA-----GMGSDP-----------------HI-
------SLEGFKDG-GI-H---L--KCSSSGWYPKPEVQWRNHQG-QCLPS-K-------
------S-------------------EA-ITQDAQGLFSLETSVVLQ-----E--GTHS-
HVSC-SIQNTL-LIQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---VPRT--S----------------S----WKG-AFLGT-LAA-LPLLMALLMILA--
F-----YFFQKQQRAQGKLKK--------LAEK-EKA---PN------------------
--------------------QAGA----DWRRAQGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PALL----------VS-----EDSRSVSSR---EVAL--SP-A------------VGD--
PQRFSEQKCVL-----------GRQRFS---TGRHY---WE-VH-V------GRRSRWFL
GACLADVP-R--V-GP--------------------------------------------
---------------ASLSPASGYWVLGLW--N--------SCEYFVLDPR-R------I
--------------------------------ALNLRVPPR---CVGIFLDFEAGKLSFF
NVSDGSH--IFTFTDTF--S-GPLCAYFRPRAHDGS---EHPDPLTIC-PVP-FTGTHAL
EED------DSDTWLQ----------------------------PY-EPL----------
-----DPALD-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPV------ASSHFS-----LPGSLLF-----
FHLLSSFA-------------------------------------------PVSVP-FTV
--------L-GPT-DPVLAMVGENTRLPCHLSPEKNAEEM-EVRWFRKQF-S---P-AVF
VYKGGREKTEM----QMKEYRGRTTF-VSEDITRGNV-ALIIHNVTAHDNGDYRCY--FQ
-E-G--RSYDEA-ITS------L--K-VA-----GLGSKP-----------------II-
------EMKGHEDG-SI-R---L--ECTSTGWYPQPHAVWRDPYG-EIMPSLD-------
--------------------------EA-YPANADGLFLVTMAVIIR-----D--HSVR-
NVSC-SINNTL-LNQ-EKETV-------IFIP-DSFTP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVV-LPSL--LLF---VSA--T
I-----CLIKKLHREKEI-PSV--------QKEIENEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------RRSLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRRVRR--GPSR----QS-V------------PDN--
PERFDCQPCVL-----------GLES FS---SG RHY---WE-VE-V------ENVMVWAV
GVCRNSVE-R--K-GE--------------------------------------------
---------------ILLLPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------VPLKERLH---RVGIFLDYEAGDVSFY
NMRDRSH--IYTCPRSPF-S-EPLRPFLRLGSDDSP-------S-LSV-QHL-QAPRGSW
CLR--------VAWSFIGQRPTTASGTNFLVSEPSREAQATSTITAQRPLEENHPPSFWS
WK-R----ISSRGP---LD---TYK--LQPHVSLMRLVL---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGPA------AAPHFS-----LPASLLL-----
-HLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTALHCHLSPEKNAEDM-EVQWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRVTF-VSKGISRGSM-ALVEHSVTAQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKA-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRNPYS-EIVPTLK-------
--------------------------EV-SIADAEALFVVTTAVIIR-----D--KSVR-
NVSC-SIKNTL-LRQ-EKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--F----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
T-----CCIKKLQREKKI-LSG--------EKEVEQEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELQW--------------------RRTFLHAA--L---T--N-PNTTH
PELF----------LS-----EDQRSVRR-------------V------------PDN--
PERFDSQPHVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTV
GVCGDSVE-R--K-GD--------------------------------------------
---------------VLLLPQNGFWTLEMF-----------GNQYWALSSPDR------I
---------------------------------LPLKESLC---HVGVFLDHEAGDVSFY
NMRDRSH--VYTCPHPAF-S-VPVRPFFRLRSDESP-------V-FIC-PAL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------NFL----------AFLLLNFHVC
VLLLQ-------------------------------------------LLMPHSAQ-FAV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYVDGKEVEDR----QSAAYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-ENIPTV--------
--------------------------EAPVFADGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKRAQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQYT-------
------------------------------------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPGPPI---G--Q-TQQQT
R-----------------------------------G--QG-S------------PVA--
LRADSWGP----------------------------------------------------
KECGES------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEGGSSRP-----L--------LCRFTSL----
LLLLQLPM---WGS---------------------------------------AEE-FLV
--------I-GPT-DPIVAVLGGDTTLPCFLFPAMSAENM-ELRWFRSKF-S---E-AVF
IYQNQQEQKEE----QMPQYAGRVLL-VRDFLTQGQA-AVRIDKVQVSDDGLYTCF--FK
-K-G--GSYEEA-TLV------V--K-VA-----GVGSAP-----------------QV-
------HIEGPEED-GV-R---V--VCMASGWFPKP-VQWRDLSG-EKFLA-F-------
------S-------------------EA-HAQDADGLFHVEASLVVR-----D--SSVG-
NVTC-SILNPI-LGQ-EKTKA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFAMS-LTV-----LGLLILGA--
G-----YFLKKEHSAKVQAQQ--------EQEFLRLF-KEEDRLTKQEA-LKTR------
------------DE-LQ----AELD-----WRKKVY--Q--AAWR---RAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFQIC-------------SVT---L--N-PRSAH
PNLS----------IS-----QEKTSVTWKDICE--K-----------------------
--QNDDRCSVL-----------GLKGIS---SGRCY---WE-VE-IRYED-KS---EWAV
GVCREDVD-R--N-DW--------------------------------------------
---------------FRECPDKGFWVVG-W--F--------EEGYCACTTPQT------W
---------------------------------LSLRQAPC---RMGIFLDYDGGDISFY
NMTDGSH--IFSFSEASF-S-GTLFPYFMFKSGD-I-------SLTIC-SMV-GGPKGLP
VPFN----K------------------------AP--------STLNEPVSPSG-EGLSS
ASGGDGVLPGPESP---LLPQGSKAV--PP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

---------------------------------------DFPGYTLSGA---IASFLFIL
LTMKLSDDFTVISPAHP-ILAEVGEDALLTCQLLPKRTAMHMEVRWYRSEPSMPV-FAYK
DGAEVTELQMEEYRGRVEWMDD-GIAKGSVALKIYNIQPSDHGQYWCHFQEGTYRVEASL
QLEVASMGSAPEVLME---------GQ---EN---------------------------N
GV--VWSVGRWF----------PKP----IH---WRDPSGEKF-----------------
-LTFAENHVQDAD--------------------------------G------------LF
HVEASLVVRDSS----------------------------------VGNVTCSILN----
PILGQEKV------------------------------KAI--SISEK-LQAELAL-LQV
--------T-GPS-QPILVRVGEDIQLTCYLSPKANAQSM-EVRWIRSHR-Y---P-AVY
VYTNGDHVTRE----QMEEYRGRTVL-VSDAIDEGRL-TLQILNARTSDDGQYWCL--FE
-N---DGVYLET-SLD------L--K-VA-----GLGSSP-----------------LI-
------TMKEKKDG-EM-Q---L--MCSSDGWFPQPHVQWRDMDR-KTIPLFS-------
--------------------------ET-LSQ----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESV------ASLHLS-----LEASLLS-----
-LFLSLCA-------------------------------------------LVSGQ-FSV
--------V-GPT-DPIQTMVGENTTLHCHLSPEKNAEDM-EVRWFRSQF-S---S-AVL
VYKGRQERTEE----QMEEYQGRTTF-VSKDINKGSV-ALIVHNVTAHDNGIYHCY--FQ
-E-G--WSYDEA-VIL------L--V-VT-----SMGSKP-----------------LI-
------EMNGHEDG-GI-L---L--ECTSGGWYPEPHAVWRDPYD-EVIPSLE-------
--------------------------ES-YAADSDGLFMVTMTVIIR-----D--CSLR-
NMTC-SINNTR-LGQ-EMRSV-------IFIP-ESFMP-------SLSSWMVVLTV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LPVLILL-----ISG--S
I-----CFIKKLHSRKES-LSA--------EKEFEHEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAH---KELGW--------------------RRTLLIAADVV---L--D-PDTAH
PELF----------LS-----EDWRSVRR--GLSR----QS-V------------PDN--
PERFDCRPCVL-----------GQEI FS---SG RHY---WE-VE-V------ENVMVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPLKERLR---RVAIFLDYEAGDVSFY
NMRDRSH--IYTCPRSNF-S-GPLRPFFRLGSDDSP-------L-FIC-PAF-RGAQGVT
VPE--------GGLILHRAGTHHHPQNQFLGLRLM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MADCPRYSLSGV---AASFLFVL
LTIKHPDDFRVVSPNLP-IMAKVGEDALLTCQLLPKRTTAHMEVRWYRSDPDMPV-IVYR
DGAEVTGLPMEGYGGRAEWMEDS-TEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSV
LLQVAALGSSPNIHVE---------GL---RE---------------------------G
EVQLVCTSGGWF----------PEPE---VH---WEDIWGEKL-----------------
-MSFSENHVPGED--------------------------------G------------LF
YVEDTLVVRNDS----------------------------------VETVSCFIYS----
HGLRETQE------------------------------ATI--ALPEM-LQTELAS-FSV
--------I-GHS-QPRPVQVGENIELTCHLSPQMDAQNL-EVRWLRSRY-Y---P-AVH
VYANGAHVAGE----QMAEYRGRTSL-VTDAIHEGKL-TLQIHNARTSDEGQYRCL--FG
-K---DGVYQEA-RVD------V--Q-VM-----AVGSTP-----------------RI-
------TREVLKDG-GM-Q---L--RCTSDGWFPRPHVQWRDSDG-KTVPSFS-------
--------------------------EA-FWQGSQELFQVETLLLVT-----N--GSVV-
NVTC-SISLPL--GQ-VKTAR-------FPLS-DSKI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMTLPVVVL-PLAMA-------------
I-----DLIKVKR-RRTNEQT--------H-TSNQENNQ---------------------
---------------------------------N-DE-S--HKQR---L-----------
--PS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-E----
--------------RL-----R--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--GL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTV
--------N-SLE-RPVLAALGGNVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--DVYEEA-IAE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-KIIPP-S-------
------S-------------------KS-HSQDGNKLFNMKMSLLLR-----D--SSHG-
NITC-YLRNPV-TGQ-EERTS-------IVLS-DKLFS-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---MCVIIGLTITLHHR---------------NRVPVSDR
K---FQLV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGFF--------------QI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPP-GSILAMVGEDADLPCHLVPTMSAETM-ELRWVSSSL-R---Q-VVS
VYAAGKEVEDR----QSAGYRGRTWI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKGYEAG-GI-H---L--ECRSTGWYPQPQIQWSNAKG-ENIPAV--------
--------------------------EAPVVVDGAGLYAVAASVTMR-----G--SSGE-
QVSC-IIRNSL-LGL-EKSAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLAGA--
C-----FFLWRQQKERIAL---------SREIEREREMKEEGYVASL-------------
----------------QETS---------IRG-----T---QWWR---KVQYMA------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------QWKMALFKPADVI---L--D-PDTAN
PILL----------VS-----EDQRTVQRAEE----P--RN-M------------PDN--
PERFEWRYCVL-----------GCGS FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LTLPEHPT---KVGVFLDYETGDVSFY
NAVDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PAQ-KGVESC-
PD--P--D-----------------------LVPD--------HFLETPVA------PGL
ANESGEPQAEVMSL---LLPAQPGQ-PSRTMR--------L-QTYTEALG----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------SLF------H--S-SV-----GLGSAP-----------------DI-
------LVEAHQDG-GI-R---V--ACQSSGWYPQPKGLWRDHQG-HLLPL-A-------
------S-------------------EN-ISQAANGLFQTEIATVLT-----E--ESNQ-
KVSC-HVWNPR-LAQ-EKEL----A---IFIA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPRA--N----------------P----WKV-ALAVI-LPL-----LAVLLPLA--
S-----YCFWRQHGVKGEVRN--------VHFFSKHK-----------------------
-------N--KE------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------LTKS-KK-----R-----WWH---------TLDVT---L--D-PDTAN
PYLI----------LS-----ADWKHVVHRDE----N--QG-L------------PDT--
LERFDKMAIVL-----------GTERFL---TGRHY---WE-VE-V--GH----KKVWTL
GVCRETVR-R--K-GH--------------------------------------------
---------------LVFIPPNGFWTIC-H--L--------DGRYTANTSN-P-----LP
---------------------------------FPVSTRPS---RVGIFLDYEAGEVLFY
NVTDRFH--LFTFTN-TF-S-GTLRPYFNPEYNIGG---TNMDPLIIC-PV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------ALA-------
--------------------------EA-YTADTDGLFRVSMAVIVR-----D--CSVR-
NVSC-SVNNTL-LGQ-EKDTV-------IFIP-ESFIP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T-LPALLLL-----VTG--S
T-----CLIRKLCREKET-MST--------EKDFENKEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAXXXXXXXXX--------------------XXXXXXXXDVT---L--D-ADTAH
PELF----------LS-----QDRRGVRR--GPRR----QS-V------------PDT--
EDRFDCRPCVL-----------GADRFA---SGRHC---WE-VE-V------ARAMVWAV
GVCRDSAP-R--K-GE--------------------------------------------
---------------ALLVPRNGFWTLELF-----------GSQYRAPSCPEQ------T
---------------------------------LPLRGRLR---RVGVFLDYEAGDVSFY
NAVDRSH--IYSCPRSLF-S-GPLRPFFRLGSDDGP-------L-SVC-PAF-TGSRGLA
V-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------NLLSDHAKEKXXX----------------
---------------------------------XX-------------XXX---------
------------------------------------------------------------
------------------------------------------------------------
-------XXXXX-XXX-----------XXXXXXXXXXXXXXXXXAVT---L--D-PETAH
PKLL----------LS-----EDRRCVRLGDR----K--QP-V------------PDN--
PQRFDFVVSVL-----------GAECFT---EGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------ATASPANGHWLVRQS----------QGSEFEALTSPQT------P
---------------------------------FRLKQPLR---CVGVFLDYEAGVISFY
NVTDHSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---RNVAPLIIC-SEL-WQSDEPL
VSKP---------------------------------------------------EEKA-
-HANGDAALTLNPS---LLPAAAPEL--PPLG---GMVLPWPSDFGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------QTC-PFS---LCYVL-----SNVCG-----AF
SWLLHLTS-------------------------------------------ACAAQ-FQV
--------L-GSD-HPITATVGGDVVLPCHLSPRMNAEHM-EVRWFRSRF-S---I-YVH
LYQSGQDHFSS----QMPEYQGRTEF-LKGGVSNGNV-SLRILRTRLSDEGQYQCL--IK
-D-G--NFYEEA-TLE------L--K-VA-----VSGSSP-----------------LL-
------SVEDYQDG-GI-R---V--GCRAAGWYPKPEMLWRDFQG-QQLPS-F-------
------T-------------------ES-TSQDKNGFFQVEKTIIIH-----K--NSKQ-
NLSC-SVQNTR-LPQ-EKDS----S---IYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
I---FPEV--S----------------P----WMV-TFFAILAIC-----LALLIFLP--
L-----IFYRLQEKKVPLTCF--------FLL--LLS-------EKRSAEILIASF----
-----NGNT-SNRNGMQEKSKFQT---RAWMHC---------------------------
------------------------------------------------------------
--------------------QH--------------------------------------
--------QVSAFQQF-HLFIFFLS-----------FFFPPGELHIT---L--D-ADTAH
PQLI----------LS-----TDGKKVQRGDV----R--QP-M------------PDN--
PERYDTYHCVL-----------GQERFV---SGRCF---WE-VD-VGTEK----GGVWAM
GVARESMK-R--K-GW--------------------------------------------
---------------INPAPQDGILALF-H--C--------NGKYWALTSPDH-----TA
---------------------------------LVLNQVPR---MIRVYLDFEGQKVAFF
NADNQDL--LFSFPLAPLSG-EKIRPWFRVGPIA-Q-------LSLMS-PLP-APHVPSM
EEPL----L------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FPGFLKQV-------PRGSS------IFF-TQLLL--
--FLQLGE------------------------------------------VN-SDE-IKV
--------L-GPG-ESILALVGETVEFPCHLSPYLDAKHM-EIRWFRTQV-S---N-VVY
LYQEQQGLSSP----QMPQFLNRTIF-EANDIADGSV-TLHVLNVAPSDEGQYGCR--FR
-S-D--NFSGEA-TWE------L--E-VA-----GLGSDS-----------------HI-
------SLEGFNEG-GI-Q---L--RCRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------S-------------------EA-IIKNAQGLFSLDTSVIVR-----E--GTHS-
NVSC-SIQNPL-LAQ-KKEFV-------LQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRP--S----------------P----WKK-AFLGT-LAA-LPLCLAVLTILA--
L-----QYFYKQRCSQEKLKE--------QGEK-DRE-----------------------
------------------RLQTEL----DWRRSEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTTAH
PSLE----------VS-----DDLKSVSSR---PGAP--SI-A------------AHG--
LQRFSEQTCVL-----------SRER FC---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--L-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------SCEYFVLDPQ-R------V
--------------------------------ALRLRVPPR---RVGVLLDYEEGKLSFF
NASDGSH--IFTFTDTF--S-GALCAYFRPRAHDGS---EHPDPLTIC-SLP-VRGPQVL
EEN------YNDNWLQ----------------------------PY-EPL----------
-----DLAWAGDEA---LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------LIIS
---RG-----------------FQV--IIIG-KNIS-LFL------------SLLF--KL
IIFKDPHSIIL--------------------------------------VFFPLGE-FHV
--------I-GPK-EPVIALVGEEAVLPCHLSPLMDAQYM-EVKWYRDNP-L---G-LVH
QYENLQDNIEP----QMAEYQGRTEV-LKDNITKGLV-ALRIHDIRPSDGGEYRCS--FE
-S-S--IYFHQA-NFQ------V--L-VT-----GSGTAP-----------------HI-
------HIDHGEAK-GL-T---L--TCTSVGWYPEPEVQWRDLQG-QRLAP-D-------
------S-------------------ET-KTPERNGVFHVETSITLD-----K--SSKE-
NAAC-YIRNPV-LPV-EKEVL-------ISVT-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPRV--S----------------P----WSA-IAPAI-AVL-----LVIVVILS--
V-----LLMRARKSK-GSLMK--------QNGELVYF-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ELRGPLSF-R-------------------R----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------V
--------V-GPE-EPILALVGEEVEFLCRLSPYLDAEHM-EIRWFRSRA-S---D-VVH
LYQEGQELHGQ----QMAQFLNRTQL-VRDDITDGSV-TLQLRGVVPADAGPYGCR--FL
-S-S--TFSGEA-IWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPQAQWRDHQG-KCLPP-E-------
------T-------------------EA-IIQDTQGLFSVETSVVVL-----E--GAHS-
NVSC-SIQNPF-LVQ-KKEFV-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGS--S----------------P----WKR-AFLGT-LMA-LPLLLALPSALA--
L-----WLFQKQRRRQEKLKQ--------EAEK-DKE-----------------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSS--RAP-AR--GL-A------------PGD--
PQRFSEQTCVL-----------SRERFA--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEMN-PF----------------FLLDLS--FI
LF-VLLPW-------------------------------------------SLSGE-FIV
--------L-GPQ-ETIIALVGRDVTFPCHLSPQLDAQHM-DVIWFHDQ--S---D-LVH
QYRYEKDYLKQ----QHLDYQGWTEF-LHQNISRGNV-ALRLHHVRPSDEGKYRCY--FA
-R-S--TYNREA-EFQ------V--D-VA-----STGSSP-----------------HL-
------HIEGAGNK-RV-R---V--VCTSAGWYPEPEVHWRNQTE-ESLSQ-G-------
--------------------------TT-ISRKENGLFSVETSITVS-----A--DSKE-
IVSC-VIENPL-LSQ-KLEA----S---VSLA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPNV--I----------------HQMEIWIGIIVCLIIGFL-----VIIIIII---
V-----KWQKTKKEKGK-E----------LHMAAR-------WHSG--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------S---------------------------------------TDD-FQV
--------I-GPS-DPIVAELGGDAILPCYLVPAMNAEDM-ELRWFRTKF-S---E-AVF
VYQNHQEQNRE----QMPQYAGRTSL-VRDLLTQGQA-ALRIKKVQASDNGMYVCF--FK
-T-R--SYYEEA-ILE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGQEQD-GV-R---V--VCKASGWFPKPQVQWTDLSG-KKFLK-F-------
------S-------------------AA-HAQDAAGLFSVEATLVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFIGS-LTV-----LGLLLFGA--
G-----CFTRREHSAKVQERE--------KQEKLCRA-KEEDQRAEEEA-LKAR------
------------DERVQ----VDLG-----WRKTAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ERFQAW-------------SVT---L--D-PGSAH
HCLA----------IS-----PERKSVTWKH-NA--E-----------------------
--YSLARCTVL-----------GLEGIT---SGRCY---WE-VE-IRSGE-GT---QWAV
GVCRGHVK-K--K-DW--------------------------------------------
---------------FTESPDTGFWVLR-Q--F--------YNRYLIWTDP-R-----QA
---------------------------------LSLRQAPR---RVGIFLDYSEGDVSFY
NMTEGSH--IFSFPPASF-S-GSLFPYFLLK-GD-V-------TLSIC-STE-GG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAAFP
---S---------------------------------PCLG---------GCL-----LT
LLLLHLRG-------------------------------------------LHAAP-FDV
--------A-GPA-EPVLALVGADAELPCHLPANLSAAPL-EMRWLREPE-A---L-ALL
VHRAGRAQDAE----QLARYRGRAEL-VLDGLAQGRV-ALRIRGVQASDDGEYRCS--FR
-R-EDGPGHGEA-RLR------L--R-VA-----ALGSDP-----------------HI-
------HMDLQDNG-ET-R---L--ECTSLGWYPEPRVQWRTPTG-EEFSS-T-------
------S-------------------ES-RDPDEEGLFTVVASVTIR-----D--PSMK-
NVSC-CIQNLL-LGQ-EKEVG-------IFIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WVV-AVAVI-LVV-----LGVLTIGS--
I-----FFTWRLYKERSRRRK--------DEFSST-------------------------
-------------------------------EKLLK-EL---KWK---KATLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LH-----EDSKSMRLEDE----R--QK-L------------PEK--
PERFDSWPCVL-----------GREAFT---SGRHY---WE-VE-V------GDRTDWAI
GVCREDVM-K--K-GF--------------------------------------------
---------------DPMTPKNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYDSGDVAFY
NMMDGSH--IYTFSKASF-S-GPLRPFFCLWSSG-------KKPLTIC-PVT-DGLEEVT
VEAD----A------------------------RD--------PSKEIPLS---PLGEDA
ASGDTDT---FHSK---LICTQANQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKLR--FS---YFF--------GYC------GY
FLFLK--V------------------------------------------MMSSGK-MMV
--------S-THK-GQVLARVGGQAELSCQVTPPRSVEYM-EVRWFKSGH-S---Q-PVY
LYRGSQGVSGE----AAPEYVNRMEF-VKEAIGKGKV-GLRIHNISISDDGLYQCL--FN
-D-S--AFGYVD-SMN------L--S-VA-----AVGLET-----------------QI-
------HIQAPGAD-GV-L---V--ECDSAGWFPEPQMEWRDSRG-KALPP-S-------
------S-------------------KS-YSQDEARFFHLKTTL-LT-----N--RSQG-
GILC-WISNPL-TGE-EKQIS-------VILA-NDLFN-------RDHIWMNLLICITLM
I--LFLL---WRC----------------------------------------------G
LWCHRVFNPEPIQILS--FL---ICTIVLFAVYLPLR---------------SRVSISDP
Q---FSLY--N--------------------SWI-TELLF-VIFF-LTQ-KLNFHETS--
I-----------------------------------------------------------
------------------------------------------------------------
-----------------------LHK----------------------------------
-ELWKQKR----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------E-FQV
--------L-GPP-EPIVAVLGGDATLSCSVSPAMDVRNM-ELRWFRTTL-T---E-SVF
VYRNQREQTEE----QTAEYAGRTSL-L---LAHGEA-ALNIHKVRVSDNGMYNCF--FK
-M-G--SFSEDA-SLE------L--Q-VA-----GVGSAP-----------------QV-
------HIQGPEED-GV-R---V--VCRASGWFPKPQVQWRDVSG-KKILA-F-------
------S-------------------EA-HTQDADLLFSVEATVVVR-----E--ASVG-
NVTC-SVLNPV-LGQ-QKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFAVS-LTV-----MGLLLFGA--
G-----YFLHREHSRKLQIQQ--------TQKNLRLA-KEEDRRIKEQA-QKAK------
------------DE-LQ----AELG-----QRKAAY--K--AAWR---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EQFQAL-------------SVT---L--D-PGSAH
GHIS----------IS-----HGNTRLTCEHP----------------------------
--GGDDLYSVL-----------GHEGIA---AGRWC---WE-VE-IMSGE-KG---EWAL
GVCREDAN-R--A-GW--------------------------------------------
---------------YLESVDKGFWVVG-W--V--------KTGHFTYVKSDT----VVP
---------------------------------GKPSKAC---WRVGVFLDYSEGDLSFY
DMTAGSH--MFSFPQAPF-S-GTLFPYFSFKCGT-V-------SLTIC-PSE-SG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
TLKLLEEYVV---------VAWK--------------------------------TGMMP
HARK-------------------TPVHMERPPSPC-----G-----AWLLGCLL-----T
LAFLQLPA-------------------------------------------QV-------
--------S-GDADKFHLAPLGGTAELPCPLLLWPGMVLS-EVRWRRPAHLPGTSQ-AVH
VLRDGQDSDED----LMPEYKGRTEL-VRDA---NSY-TLHIRNVRLEDRGPYQCQ--FR
-V-G--NQSREG-NVT------L--Q-VA-----VLGSDP-----------------FI-
------HVEGYDAG-WI-Q---L--VCRSMGWFPKPWMEWRDTEG-RLLLSVL-------
--------------------------EN-HSLDETGLFRTAVFSRVR-----D--STLG-
NVSC-TVRNEF-LGQ-EKKAF--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------GAPAPTS
L---S-----S---------------------PE-VALSVV-LPI-----LGLLILLG--
I-----WVICKQKRSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRKELKL-----------KRAAANAGWRRARLHFVVVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDK----K--RP-V------------PDH--
PQRFDFVVSVL-----------GSEC FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RRNEYEALTSPQT------Y
---------------------------------FRLKESPK---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---RNTAPLIIC-TEL-QKSEASI
VTKQ---------------------------------------------------EEKS-
-QANGDVSLKMNPS---LLSPQGSEL--LPFH---DT---WPSNLSPALQGFKAPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MERMNLGSEKPL-----KI--------DFELP-----
----RKHS---VGV-------------------------------------QKASW-FSV
--------K-GPA-EPITVLLGTDATLPCQLSPKQSAAHM-HIRWYRAQL-T---P-AVL
VFHNGQVQGEV----QMPEYEGRTQM-LGHDIDTGSV-ALQIQQVQASDDGLYHCQ--FS
-D-G--FTSQEV-SIE------L--Q-VV-----GLGSAP-----------------LV-
------HMTGPENN-GI-R---V--LCSSSGWFPKPRVQWRDTIG-DTLLS-S-------
------S-------------------ES-QTLDRDGLFHIETSLLVT-----D--RAIG-
NVIC-SIQNPI-WDQ-EKSKA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPTT--S----------------P----WKV-ALACI-LPI-----LLVILAWT--
S-----FATWKEHQVKRREEK--------QLSKEQWE-MRQMKEETKSA-VK--------
----------------------DRD-----RRKALY--KE--DWK---MALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQL-------------APVM---I--D-HEMPD
QNKS----------DP-----KTE------ENRG--EGTAD-P------------SVDNS
--QVDDNIITL-----------SQEGFM---LGRYY---WE-VD-VEDTE------EWTL
GVYELYTE-D--A-S---------------------------------------------
----------------PTE-SKKFRVLE-K--K--------GDGYRALAFCSQNISLEEP
---------------------------------LQLETRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFDQNTF-L-GSLYPYFKRNSMA-L-------SPTEQ-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--EL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTV
--------N-SLE-RPVLAALGGNVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNISADDDGQYHCF--FK
-D-G--DVYEEA-IAE------V--K-VT-----ATSLEV-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDGNKF------LLLR-----D--SSHG-
NITC-YLRNPV-TGQ-EERTS-------IVLS-DKLFS-------WDSVWILILVAILAV
LLF-FVMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---MCVIIGLTITLHHR---------------NRVPVSDR
K---FQLV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGFF--------------QI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLSFHVC
FLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPP-GPILAMVGEDADLPCHLVPTMSAETM-ELRWVSSSL-R---Q-VVS
VYAAGKEVEDR----QSAGYRGRTWI-LRDGIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEAG-GI-H---L--ECRSTGWYPQPQIQWSNAKG-ENIPAV--------
--------------------------EAPVVVDGAGLYAVAASVTMR-----G--SSGE-
QVSC-IIRNSL-LGL-QKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLAGA--
G-----FFLWRQQKEIIAL---------SREMEREREMKEEGYAASM-------------
----------------LETS---------LRETLQE-E---LRWR---KVQYMA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASWH-C-----RSPASLF-----
FLVFSRSV-------------------------------------------LVSVQ-FTV
--------V-GPA-EPTLAMVGENTTLRCYLSPEKNAEDM-EVRWIRGQF-S---P-ALL
VYKGRRERAEE----QMVAYQGRITF-VSTDISKGSV-ALVIHNVSAQDNGFYRCF--FQ
-E-G--RSYDQA-ILR------L--T-VA-----GMGSIP-----------------LI-
------EMKTLGDG-SI-W---L--ECTSVGWYPEPCAVWRGPSG-EVVPAVE-------
--------------------------EE-YTADTEGLFTVTMTVIIR-----D--CSVR-
NMTC-SVNNTL-LGQ-ERESV-------IFIP-EPSVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SP--T----------------P----WMV-AVAVT-LSALTLILF---MSG--S
I-----CLIKKHHREKEI-LS---------------VEKEIEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ETAQQLLEELKW--------------------RRTLLHAADVT---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSR----QR-V------------PDN--
PERFDCRPCVL-----------GQES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRESVE-R--K-GE--------------------------------------------
---------------APLVPPNGFWTLEMF-----------GGQYRALSSPEK------I
---------------------------------IPLKTRLC---RLAIFLDCEAGDISFY
NMRDRSH--IYTCPRAGF-A-GPLRPFFRLGSDDGP-------L-FIC-PAF-TGAQGVT
VPD--------GGLILYRAKPVPCSRVGSP----W-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------ME----MA-----G-----GCSPACCI-----A
LACLPLPV-------------------------------------------CVSXX-X--
--------X-XXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXXXGLPL-AV-
HVRDGQDQAEG----PMPEYKGRTAL-ERDP-QEGSV-TLKIRHVRLEDRGPYLCQ--VQ
-I-G--NLSRKG-TVT------L--Q-VA-----XXXXXX-----------------XX-
------XXXXXXXX-X--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------XXX-----XXXXXXXX--
X-----XXXXXXXXXXXKLLYE--QVMEVX-XXXXXXXXXX-XR----------------
---------------------------------LH-------------RAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRTAANSGWRRARLHFVAVT---L--D-QDTAH
PKLI----------LS-----QDRRSVKLGDR----R--QP-V------------PDN--
PQRFDFVVSVL-----------GSEYFT---AGCHY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------RGTEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHTF--S-GPLRPFFEPCLHDEG---KNTAPLIIC-PEL-QEPEKSP
R------------------------------------------------------PEKG-
-HANGDV--KVDPS---LLPPQAPAA--SPLT---NTILPWASELGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MMDVP
---VS-------------------LDPLQGA-------SLPCS------LFFLTHL----
-FLLQPGM------------------------------------------LN-SEE-VQV
--------V-GPG-EPILALVGEEVEFPCHLSPYVDAEHM-EIRWFRSQA-S---N-VVH
LYQERQELFGL----QMAEFQNRTTL-IKDEIADGSV-ILQLHSVVPSDEGVYGCR--FL
-S-S--DFSGDA-VWQ------L--E-VA-----GLGSDP-----------------RI-
------SLEGFKEG-GI-Q---L--RCSSGGWYPEPKAQWRDHQG-RCLPP-E-------
------F-------------------EA-IIQDTQGLFSLETSVVVQ-----G--GAHS-
NVSC-SIQNPL-LAQ-KKEFV-------VQIA-XXXXXXXXXXXXXXXXXXXXXX-----
----------------------XXXXXXXXXXXXXXX-XXXXXXXXXX------------
-------------------------------------------XXXX--XX---XXXXXX
P---NQAA--S----------------D----WR--------------------------
------------------------------RA----------------------------
-----------------------------ER----Q-----AEWR---EARQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------IS-----EDGKSVWA-------GEGAQ-G------------AAA--
PPRFAEQTCAL-----------GRERFS---AGRHY---WE-VH-V------GRRSRWLL
GACLA-------A-GR--------------------------------------------
---------------ARLGPAGGYWLLGLW--N--------GCEYFALDAH-R------V
--------------------------------ALSLRVPPR---RVGVFLDHEAGRLSFF
NVSDGSH--IFTFADTF--S-GALCAYFRPRAHDGG---EHREPLTIC-PLP-VRGTWVP
EED------DRDAWLQ----------------------------PY-ELS----------
-----DPALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MENHRKPS-----LLF---HVS-CLF-------
-VLIQLLS---WVT---------------------------------------TKE-FQV
--------F-GPS-DPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRF-S---A-AVL
VYRDQEEQKRE----QLPEYSQRTSL-VKEQFHQGTA-AVRILNVQAPDSGIYICH--FK
-Q-G--VFYEEA-ILE------L--K-VA-----AMGSVP-----------------EV-
------YIKGPEDG-GV-C---V--VCITSGWYPEPQVHWKDSRG-EKLTA-S-------
------L-------------------EI-HSEDAQGLFRTETSLVVR-----D--SSVR-
NVTC-STFNPI-LGQ-EKAMA-------MFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--S----------------P----WKP-AFFVT-LTM-----MGLLVLGT--
S-----YLFRRERSARLIVQE--------LTGNLQRV-EDNKA--EEDT-V---------
------------RT--IDALMVELA-----QRKAAY--R--AAWR---KAQLYA----D-
------------------------------------------------------------
------------------------------------------------------------
---------------W-RK------EQFQAW-------------TFT---L--D-PASAH
TNLA----------IS-----QDRLTVTRKDFTR--C-----------------------
---LEDLSCVL-----------GIRGIS---SGRYY---WE-VK-LTNIE-GS---KWIL
GVCREGVV-R--K-NF--------------------------------------------
---------------YFETPRKGFWTVG-Q--S--------SKGHWAYIDSGR-----TS
---------------------------------LSVRQAPK---SVGVFVDYTEGDISFY
NMSDMSH--MFSFPKASF-S-GTLFPYFRLRSGN-V-------SMIIN-SME-CASESSE
GEEG----RRGRKRSRRG---GRGGGGRMGRS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDIP
---D-------------------FPHWSQSS-------SLSSC------LL---------
-LLLYFME------------------------------------------LN-AEE-LMV
--------F-GYR-EPILAMVGEEVEFPCYLISKLDAEDM-QIRFFRNKI-S---E-IVH
DYQDRQELFNR----QMVQYQGRTQL-LKDYIQEGSV-ALRLLHIIPADEGQYGCL--FQ
-S-K--DFSNNA-TWE------L--E-VA-----GLGSDP-----------------NI-
------YFEGFEEG-GI-R---L--TCSSKGWYPKPKAIWKDYQG-QQLPF-L-------
------S-------------------KT-ITQDAQGLFHLEMSVVVK-----E--GAHS-
HVAC-SIQNTL-LVQ-KKEFT-------LHIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPKN--S----------------V----WRG-SFIGT-LMG-LVSLLVLCMILA--
L-----YFFQKQRRSKEKLRK--------KSEK-EKG---KFTAE-----L---------
-----------------GKLQTEI----DWRRAEGQ-----AEWR---AAKRYA----VN
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PDTAH
PGLN----------VS-----EDGKSVFYWNI------KQD-L------------PDN--
PKRFENQLCVL-----------GQEGFI---SGKHY---WE-VE-V------GEKSRWLL
GVCSDSVD-R--K-VE--------------------------------------------
---------------GKLCPGMGYWVIGLW--N--------GCEYFIFNPH-R------V
--------------------------------SLTLRVPPR---RVGVFLDYEAGKVSFF
NVTDNSH--IFTFTDKF--S-GTLRPYFRPRSQDGG---EQVIPLTIC-PLP-KKGDRVA
A-E----DDDCDTWLQ----------------------------PY-DLS----------
-----ESAEI-------RILNT--------------------------------------
------------------------------------------------------------
-----------FVE----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------TEPA------ASLHFS-----LPASLL-L----
-PLLSLLA-------------------------------------------LVSAQ-FTV
--------Q-GPA-DPILAMVGENTTLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVL
VYKGGRERAEE----QMEEYRGRTTL-VSKDISRGRV-ALLIHNVTAQENGIYRCY--FQ
-E-G--RSYDEA-IIH------L--K-VA-----SLGSKP-----------------LV-
------EMKGHEDG-GI-R---L--ECTSGGWYPKPLAVWRDPYD-QVVPALE-------
--------------------------EA-YTADADGLFMVTTAVIIR-----D--SSLR-
NMSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------SISPWVVILAL----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAILIIL-----MAV--S
I-----CYIKKLHREKKI-LSG--------EKKGELEGKEFA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSQ----QR-V------------SDN--
PERFDCQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMAWTV
GVCRDSIE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------ENKYRALCSPER------I
---------------------------------LPLRERLG---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSPF-A-GPLRPFFRLGSDDSP-------L-FIC-PAL-AGANGIT
VPE--------EGLILHRARTPHRPQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGV---VASFFFVL
FTMRQPDSWRVIGPAHP-ILARIGEDALLTCQILPKRAMMPTKMTWYRSDPNEVV-FAQW
DGADVTEMQMEEYRERVEWVKD-DVPEGSVTLKINNIRPSDNGQYWCCFQEKNYYEETSL
LLEVAGVGSSPYIHME---------GP---IE---------------------------S
GVQLVCTAKGWF----------PEPQ---VY---WEDATGKKL-----------------
-LSVSEHSIQDEN--------------------------------G------------LF
YVEATLVVRNAS----------------------------------LETVSCFIHN----
PILNEEKS------------------------------SVI--SIPEK-LQNELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCCLSPKTNAQSM-EVRWLQSHH-Y---P-AVY
VYADGEHVTEE----QMTEYRGRTAL-VSDAINEGRL-TLQIHNATTSDNGQYRCR--FE
-K---DGVYQEA-SLD------L--K-IV-----GLGSSP-----------------LI-
------TIIGQKDG-EI-E---L--MCSSEGWFPKPHVQWKDMEA-KIIPSFS-------
--------------------------EV-LTQGSHGLFHVKTSLLVT-----N--SFIV-
NVTC-SISNPL-LGE-EKMAT-------FSLS-ESMM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------S---------------------WKTVLICGL-LLAA-----------A--
V-----GLVMRKSYKKAA------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AAPRCR-----ARGSLLF-----
LALLCGCA-------------------------------------------LLSAQ-FTV
--------V-GPA-DPVLAMVGEDTTFHCHLSPEKNAEDM-EVRWFRTHF-S---R-AVL
VYKGGRERTEE----QLEEFRGRTTF-VSDGIKQGSV-ALVIHNVTAHENGIYHCY--FQ
-E-G--RSYDEA-IMR------L--M-VA-----GLGSKP-----------------LI-
------EMKGHEDG-GI-R---L--ECTSVGWYPEPHAVWRDPYG-EIMPALE-------
--------------------------EA-YTVDADGLFTVTVAVIIR-----D--CSVR-
NASC-SVNNTL-LGQ-EKETV-------IFIP-ESLPP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--L----------------P----WMA-GLAAL-PPSL--LLL---VAG--V
L-----CLARKGHREKEV-EN---------------EERETACQEPG-------------
------------------------------------------------KEDVE-------
------------------------------------------------------------
-----------KEKER--E-----------------------------------------
----IRE-QLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LT-----EDRRGVRR--GPSR----QS-V------------PDN--
PERFDCRPCVL-----------GLES FS---SG RHY---WE-VE-V------ENVMVWAL
GLCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPRNGFWTLEMF-----------GNQYRVLSSPEK------I
---------------------------------LPLKERLR---RVGIFLDYEAGDISFY
NMRDRSH--IYTCPRSPF-S-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGARGVA
VPE--------GGLILHRTGTQRSHQGQFP----GLRAK---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPD-KPVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQF-S---S-VVH
LYRDGEDQPFM----QMPQYQGRTKL-VKDSIAEGHI-SLRLENITVLNAGLYGCR--IS
SQ----SYYQKA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-DI-Q---L--LCQSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNRDMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSR-EVESR-------VQIG-DTFFEP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQCK----QE--------REKH---------------------------
---------------------G--PVP--------------YSWF---QQGQ--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------DQRCSHIPAASLLLV---L--A------
---------------------------SRGPG----P--KK-L------------EKK--
ARTG--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------MQR-------------QF
----SKASR-----------PCLPWVLMEPA------AALHFS-----LPASLILL----
LLLLRLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRRRTTF-VSKDISRGSV-ALIIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GIVPALK-------
--------------------------EV-VTPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SISDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKEKKI-LSG--------EKEFELETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------REK----EL----------------------------------------
-QV---QEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVQ-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-IGASGVT
VPE--------EGLTLHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MERA------AALRFS-----APGSLLL-----
VVMLGGSA-------------------------------------------PLSAQ-FTV
--------V-GPT-DAVLAMAGENTKFHCHLSPEKDAEHM-EVRWFRSQF-S---L-AVL
VYKAGRERTEE----QMEEYQGRTTF-VSEHINKGSV-ALIIHNVTAHDNGIYHCY--FQ
-E-G--RSYDEA-VMH------L--M-VA-----SLGSKP-----------------LI-
------EMKGHEDG-GI-R---L--ECTSIGWYPEPHATWRDPYG-EIMPALE-------
--------------------------EA-HTVDANGLFMVSMAVIIM-----D--FSVR-
NASC-SVNNTL-LGQ-ERETV-------IFIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--F----------------P----WMV-SLAAV-LPSL--LLF---SAG--S
I-----CLVRKLHRGKEV-EN---------------EAKEVACEEPE-------------
------------------------------------------------KEQVE-------
------------------------------------------------------------
-----------KEKER--Q-----------------------------------------
----IRE-QLQEELHW--------------------RRSLLHAADVV---L--D-PDTAH
PELF----------LT-----EDRRGVRR--GPSR----QS-V------------PDN--
LERFDCRPCVL-----------GLDS FS---SGRHY---WE-VE-V------ENVMVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPVKERLR---RVGIFLDYEAGDISFY
NMRDRSH--IYTCPRSPF-S-GPLKPFFRLGSDDSL-------L-LIC-PAF-TGARGVT
VPE--------GGLILHRMGPHRSH-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------AK-FIV
--------I-GSH-NPVTAILGQEVVLPCHLSPRMSAANM-EVRWFRSEF-A---S-IVH
LYYDGKDQYDM----QMSEYQGRTEL-MKAGLTEGNV-HLRILNIRRSDEGQYLCF--VQ
-D-D--TVYEEA-VLE------L--R-VA-----DLGAAP-----------------LI-
------SIEGHQDG-GI-R---V--VCQSAGWYPEPEVQWRDLSG-RHLSS-L-------
------S-------------------KT-TSLGDNGLFETETALIVK-----E--HSNK-
NLSC-CIRNTL-LKQ-EKES----A---VYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPKV--N----------------P----WMV-VLTVI-LVV-----LFGFIVLT--
V-----YLFKMKLYK--------------IWG--ETKLDE-FCTKRQI------------
--------------PWLEEMGAS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------LTSMGATNVT---L--D-PDTAH
PELV----------LS-----QDRKSVRWGVT----R--QD-L------------PDT--
PERFDYWTCVL-----------GCEGFT---SGRHC---WE-VE-V--GD----GQYRAV
GVARESVS-R--K-GR--------------------------------------------
---------------INSNPEGGIWAVH-W--L--------KDQFLVPTSP-D-----TS
---------------------------------LPMSQVPS---RIRVCLDCDRGQVTFI
NAGDEAS--IFTFPPGSLPG-ERIRPWLWVW-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------FVDLF
---L-------------------ALNNAKQV-------PMLSG------VFFLTHLTL--
--LLQPVE------------------------------------------LN-SEE-VKV
--------I-GPG-EPILALVGEEVEFSCYLSPYLDAEDM-EIRWFRSQT-S---D-VVH
LYRGGQELHSQ----QMVQFQNRTKL-IKDFIMDGMV-NLKLHGIIPADEGLYGCR--FL
-S-T--NFSREA-IWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPQAQWKDHKG-QCLSP-E-------
------M-------------------EA-IVQDAQSLFNLETSVVVQ-----G--DAHN-
NVSC-SIQN SF-LIQ-KKEFT-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGN--S----------------P----WKR-AFLGI-LVG-LSLLLALLVTLA--
L-----YFFQKQRRSQEKLKE--------QADK-DKE---IL--TAN---L---------
-----------------ERLQTEL----DWRRAEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
HSLE----------VS-----EDGKSVSS--CTA-VP--GP-V------------MGD--
PQRFSEQTCVL-----------SCQH FS---G GRHY---WE-VH-V------GRRSRWFL
GVCLATVP-R--M-GP--------------------------------------------
---------------AQLSPASGYWVMGLW--N--------HSEYFVLDPH-R------I
--------------------------------ALTLRVPPR---RVGIFLDWEAGKLSFF
NVSDGSH--IFTFTDTF--S-GTLCAYFRPRAHDGG---EHPDPLTIC-PLP-VRRTCIL
EED------ERDAWLQ----------------------------PY-GPS----------
-----DPTLG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GL---CFY--------GHC------IV
MFLLQ-MV------------------------------------------TASSEP-FIV
--------N-GLE-GPVLASLGGNLELSCQLSPPQQAQHM-EIRWFRNLY-T---E-PVH
LYRDGKDMFGE----IISKYVERTEL-LKDGIGEGKV-TLRIFNVTVDDDGSYHCV--FK
-D-G--DFYEEH-ITE------V--K-IT-----AINLQV-----------------QI-
------HVHPPNTK-GV-I---V--ECHSGGWFPRPLMQWRDRRG-EVIPA-A-------
------S-------------------KS-HSQGRDKLFNMKISLLIS-----E--SFFQ-
KVIC-CLQNPL-TGQ-EERTS-------VILS-DAFFS-------WNRIWKMILGIILSM
MVV-SIFVFSCLL-HHEHKVCK--------------------------------------
---WKWDAPWIKGLLIMTSS---MVTVVLVMVYLHMK---------------QRVPVSDV
H---FELD--T--------------------LWV-EDISV-ILCS-LMV-PATMLV-S--
Y-----TYFRLKDWC--------------QHNHAQRV--------FTSN-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------T-GPG-KFVQASVGEDAVFSCSLFPETSAEAM-EVRFFRNQL-H---A-VVH
LYRDEEDWEFM----QMPQYRGRTKL-VKDSIREGHV-SLRLKNITLLDMGLYGCW--FS
SQ----IYDEEA-TWE------L--Q-VS-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTVKWKGPQG-QHLSSDS-------
---------------------------R-ANAGGHNMYDVETSIIVQ-----E--N-AG-
SISC-SIHLAE-LSH-EVESK-------VLIR-GEWGEG---------------------
------------------------------------------------------------
------------------------------------------------------------
----------G----------------G----RPL-VLA---------------------
------------------------------QI----------------------------
------------------------------------------SSS---V-----------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------THASSLPHRTSVEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QK-V------------PYS--
TKRFT-RQSVV-----------ASQG FQ---AG KHY---WE-VD-V------GQHVGWCV
GVCQDDTD-R--R-KDS-------------------------------------------
---------------VTFSPNDGYWVFGLT--T--------EYLYFTFNPH-F-----IN
---------------------------------LSLETPPT---RVGVFLDYEGGNISFF
NTNDQSR--I-CILTCQFQG-L-LRPYIQHVIYE-E---KNRTPIFIC-PVS-W------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MTVFA
---N---------------------------------CGFP---------RCL-----LT
LVLLQLPQ------------------------------------------LDS-VP-FDV
--------I-GPP-EPVLAMVGEDAELPCRLSPNASAESL-EVRWFRGKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRSVRVSDDGEYTCF--FR
-E-DG--SSEEA-LVR------L--K-VA-----ALGSDP-----------------HI-
------TMQVQENG-EI-Q---L--ECTSVGWYPEPQVQWRTSRG-EKFPS-T-------
------A-------------------ES-RNPDGEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQNPL-LGQ-EKEVE-------IPIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIA-AVAVI-LMV-----LGLLTIGS--
I-----FLTWRLYKERSRDK---------NEFSAK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------IY-----EDSKSFQLEDS----H--QK-L------------PEK--
PERFDSWPCVL-----------GREA FT---SGG HY---WE-VE-V------GDRTDWAI
GVCRENVM-R--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGNISFH
SMNDGSH--IYTFSSVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PVA-DGPEGVT
VIAN----A------------------------PD--------ISKEILLS---PMGEDS
ASGDAES---LHSK---LIPTQPSQG--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSAGWYPQPQIQWSDAKG-ENIPAV--------
--------------------------EAPVVADRVGLYAVAASVIMR-----G--GSGE-
GVSC-IIRNSL-LSL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIT-ALAGT-LPI-----LLLLLAGA--
S-----YFLWRQQKEITAL---------SSEIESEQEMKEMGYAAAE-------------
----------------QEIS---------LRG---------------------I------
------------------------------------------------------------
------------------------------------------------------------
----QRGEES--------------------------SSDTNKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MLKRLKKH-V---------VAWK--------------------------------MCVMP
HSRK-------------------MSVHMERP-SPC-----G-----SWLVGCLF-----T
IAVFQPPV-------------------------------------------QV-------
--------L-GDAGKVYIAPLRDTANLPCPLFLWPNMVLS-EMRWYRPGHLPRT-Q-AVH
VFRDGQDRDED----LMPEYKGRTAL-VRDA-HKESY-ILQISNVRLEDRGLYQCQ--VW
-V-G--NSSRED-NVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-E---L--LCQSVGWFPKPWTEWRDTTG-RALLSLS-------
--------------------------EV-HSLDENGLFRTAVSSRIR-----D--NALG-
NVSC-TIHNEA-LGQ-EKTTA--------------------------------MII----
------------------------------------------------------------
-----------------------------------------------------GAPERGS
L---S-----S---------------------PA-VALSVV-LPV-----LGLLILLG--
I-----WLICKQKKSKEKLLYE--QAMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PERFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGIFLDYEAGIISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---KNTAPLIIC-TEL-QKSEESI
VPKQ---------------------------------------------------EGKD-
-RANGDVSLKMNPS---LLSPQGSEL--FLLN---DT---WPSNLGPALKGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGSI--QI---IFA--------AYC------VV
LCVLQ-ML------------------------------------------VLSSEQ-FTI
--------T-GLE-RPVLAPLGGILELSCQLSPPQNAQQM-EIRWFRNRY-T---E-PVY
LYRNGKDLHGE----TISKYVERTEL-LKHDIGKGKV-TLRVFKVTVDDDGSYHCV--FK
-D-G--IFYEEH-ITE------V--K-VT-----ATSSDI-----------------KI-
------IMHPPNIK-GV-M---L--ECHSRGWFPQPHMEWRDSNG-QVIPA-T-------
------S-------------------KS-QSQDENKLFNMTMNLFAD-----V--GLHQ-
IVTC-YIQNLL-THQ-EESIS-------IVLT-GDLFS-------WKIDWILILSIIACV
MIP-YSMTSYLQQ-HLIHGS----------------------------------------
--CSQRSHHWRKNAMVCMSS---VIAIIGSMLILHLK---------------QRVPISDQ
H---FELD--T--------------------LYL-EDISV-ILCV-VIV-FNLKLN-L--
L-----TYYRLERKY--------------DGCTPGCK--------ACFYIL---------
------------------------------K-----------------IIII--------
--ILPFVFTFGCYNAIF-----LKYHQL------------QK-------KVSIPDPLYYF
YTSWL-------------------------------------------------------
------------------------------------------------------------
----------------VNMEMLGVFLVFFPTF----I--NL-------------------
------IEFSQ-------FIK--------------T----------------VPKPIWLC
QE--NMREDD-AIRHR--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
FFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPKIQWSNAKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRGIQQD-G---EKYK---NTDLFL------
------------------------------------------------------------
------------------------------------------------------------
----IC---IS--------------------FLSEWKMALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCESFM---SGRHY---WE-VE-V------GDRKEWHI
GVCSKIVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYQILTKL-R-----TN
---------------------------------LTLPELEI---CHSAMLRMDTS-----
------------------------------------------------------------
--------------------------------------------------G------PSL
ANESGKPQAEIMSL---LLSAQPES-EGLLLH--------S-NQSQP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAKI-HCGN-ASLPSC----LIT---FIF--LQ
FLPHG----------------------------------------------NGKAD-FSV
--------L-GPP-GPLLAIVGQDKSLPCKLSPNISAEGM-ELKWYRDHL-F---S-VVH
MYKNGEDVYEE----QMEEYQGRTTF-IRDHIARGEA-TVTIHNITTFDNGTYHCL--FK
-E-H--TSHSEA-TLW------L--K-VA-----GLGSVP-----------------RI-
------QVADTQDK-GT-W---A--DCTSAGWFPEPQVEWRDLRG-QMMPA-M-------
------T-------------------HF-LVSATTGLLTVMSRVVLQ-----D--KAVE-
GLTC-SISNPL-LPE-RKVV----A---HHLA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FRRF--L----------------S--MEWRP-VLPLI-LIA-----LGLATVAL--
V-----CVFGKHTREEPKTCV--------EKEA---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------EDEDGVSPS---L--D-PDTSS
PKLM----------VS-----EDQKNVRRLLF----E--QD-L------------PPS--
SRRFDQDPCVL-----------AQEQ FW---AG RYY---WE-VE-V------GDRKAWIL
GVCLESLG-R--E-GR--------------------------------------------
---------------IPKSPKHGLWAVE-F--Y--------KKKFWALTYP-R-----TR
---------------------------------LSPPQPFR---LVGVLLDCDAGEISFY
NVTCGSL--VYKFSGLAF-S-GPLKPFFCLWTHDPR-------PLTLC-SVV-TETQD-T
EPSG----G------------------------P--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKKI-HGQD-TFPHSF-S--LTL---I-L--LQ
L----LSS-------------------------------------------PWKAD-FTI
--------S-VPG-ETVLAMMGEDTELLCHLSLNVSIEDM-DLRWYRDQP-L---P-AMH
MHRKGEDMQEE----QMEWYWERTTF-VRAGLAQGQA-VVRIHNINAFDNGTFHCP--FR
-D-G--AVFQEA-KLW------P--R-VA------LGSEL-----------------TV-
------HIQVTQDE-GV-Q---A--ECTLADCYP----EWRGIRE-QILPS-V-------
------T-------------------NL-SASPTTGLTMMSSMTIPH-----D--RTVG-
GLSC-SISSPL-LSE---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNVSADDDGQYHCL--FK
-D-G--DVFEEA-IAE------V--K-VS-----ATSLEI-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDGNKLFNMKMSLLLR-----D--NSHG-
NITC-YLRNPV-TGQ-EERTS-------IVLS-DKLFP-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRK-CCD---------------------------------WN
-------SPCLIGIGIVFSS---MCVIIGLTITLHHR---------------NRGFFQI-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------SEWR---AAQQYA----VN
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-SASAH
PSLE----------VS-----QDDRSVSSRW--AALF--PA-V------------PGD--
PQRFTEQMCVL-----------SHQCFR---TGLHY---WE-VD-M------CQRSRWFL
GACLEAVA-R--A-GP--------------------------------------------
---------------ARLSPAAGYWVMVLW--N--------GCEYFVLEPR--------R
--------------------------------ALSLHVLPQ---RVGIFMDCEAGKLAFF
NVSDGSH--IFTFTDTF----GALCAYFRPRA-DGS---TRPDPLTIC-PLP-LRGTPVP
EEE------DGDTWAQ----------------------------P---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------AEE-GKV
--------I-GHR-EPILAMVGEEVEFPCYISSTLDAEDM-EIRFFRNKV-S---E-IVF
IYQDRQELFNK----QMVEYRDRAHL-VKDYIQEGSV-SLRLFHIIPADEGQYGCL--FQ
-S-K--DFSNSA-TWE------L--E-VA-----GLGSDP-----------------HI-
------YFEGFEEG-GI-Q---L--RCSSKGWYPRPKAVWKDYQG-QQLPS-L-------
------S-------------------EA-ITQDAQRLFHLEISVVVK-----K--GAHT-
NVTC-SIQNTL-LVQ-KKEFT-------IHIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPKN--S----------------A----WRG-AFIGT-FMG-LAVILVLFMILA--
F-----YFFQKQQRSKEKLKK--------KSEK-EKG---KITVN-----L---------
-----------------SKLQTEI----DWRRAEGQ-----AEWR---AARRYA----EL
A-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------C---T--KEIRSAS
P------------------------DIMNSQS------TQD-L------------SDD--
PKRFEDQLCVL-----------GQEGFI---SGKHY---WE-V--V------GEKSRWFL
GVCHDSVE-R--K-QE--------------------------------------------
---------------VKLCPGKGYWVLGLW--N--------GCEYFIFNPH-R------I
--------------------------------SLTLRVPPR---RVGVFLNYEAGTVSFF
NVTDNSH--IFTFTDKF--S-GILRPYFRPRSHDGG---EKVIPLTIC-PLP-TKGDGVA
AKD----DDDCDTWLQ----------------------------PY-DLS----------
-----DNTEN-------GW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVGALNF----------------SLLRGL--FT
ILLLQMSI---WGS----------------------------------------DS-FLV
--------I-GPS-EPIVAMLGTDTVLPCRVSPAMSMESM-ELRSFHSQF-S---E-AVY
VYKDGMEQVGE----QLVDFKGRAEL-VKDYITEGRV-AVRIYSLWISDNGMYKCC----
------SDFEEA-TLE------L--K-VI-----GLGSGP-----------------RV-
------FMVGPEDK-GI-R---L--TCTGKGWFPQPEVQWTDARG-EKIPT-L-------
------S-------------------ED-ETQDDDGLFQIEASLIVR-----D--SSKT-
KVSC-SMKNPF-FGQ-EQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WKV-AFAGT-FFI-----LGIFLGAV--
V-----FLAWKEQQEKKRVWE--------L----QED-KEKESKAKE-------------
------------------PLEKEL------------------DW----------------
------------------------------------------------------------
------------------------------------------------------------
-----------------RK------AKLYAV-------------AVT---L--D-PDNAH
PNLI----------IS-----ENRKQVSLMENVP--Q-ICD-A------------SVYQG
QEESEAVFSVL-----------GQNYFN---TGTHY---WE-VE-VNIGTEAGPGTKWAV
GVCSNTVI-R--------------------------------------------------
-----------------DGPEKNFWVVA-Y--E--------EGEVKIP-TSS------ES
---------------------------------LSLRQHP----RIGVFLDREGGDVSFY
NMVDGSH--ISSFTRITS-C-GTLCPYFSLQGAG-T-------SVTIC-STS-D------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLRLSV-------------------------------------------HV-SG-H--
--------A-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-AVH
IFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAV---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPRP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPPDLGPALQELKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLRIS-----PQGSLLF-----
LLFLSTFS-------------------------------------------QLSAQ-FTV
--------V-GPP-EPVLAMVGESSTLRCHLSPEKSAEAM-EVRWFRTHS-S---A-AVL
VYRDGRERPEE----QMQQYHGRTSL-ESAGLGRGRA-ALVIHNVTAHEDGDYSCS--FQ
-E-G--RSYDEA-IVR------L--E-VA-----GLGSKP-----------------LV-
------EMKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG-EVVPALE-------
--------------------------EA-YTAGAIGLFTVALAVIIR-----D--DSVR-
NMFC-SIHNTR-LGQ-EVEAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVI-LPTLILL-----MAW--G
V-----YLVKKLQKEKEV-LAVDKEVLA-MEKEVEREEKEIAWKKLW-------------
------------------------------------------------EERLT-------
------------------------------------------------------------
-----------EGRSFISI-----------------------------------------
----SFPKQLQEELRW--------------------RRTVLHAADVV---L--D-PATAH
PELF----------LS-----EDRRSVLR--GTRR----QE-V------------PDN--
PERFDLWPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVRAWAV
GVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGDGVWALELF-----------GGHYRPLAAPAL------L
---------------------------------LPLRERLG---RVGVFLDYEAGDVSFY
NVRDHLH--IYTCPRSAF-T-GPLRPFFLLESINSP-------L-AVC-PAS-VGTQGAR
EPG--------GATAVRVVTLWSL------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MART-RSRA-ASVASS----LIF---LLF--LK
LLPLG----------------------------------------------NGKAD-FQV
--------L-GPQ-HPVVAMLGEEAELRCWLSPNISAHLM-ELRWFREQP-S---P-AVH
VRRAGQDKPEE----QMPEYHNRTTF-VDLDMARGEA-ALRIHRVTASDNGSYHCL--FK
-E-D--RVQEGT-TLW------L--Q-VA-----GVGSKP-----------------RI-
------QVIHTPDR-AV-W---A--ECTSEGWYPEPKIEWRGQRG----CA-K-------
------T-------------------NF-SVSATTGLWAVVSRVALQ-----D--AAVE-
GLSC-SISNPV-LPE-RKVA----K---SHLP-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---SRGS--Q----------------F--MKWRL-ALPLS-LLA-----MGLLMAGV--
I-----CLFGKCQREVNRTQL--------MEEIER-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GG-E-------------------DPSLFTVSPS---L--D-PDTAS
PKLI----------VS-----EDQKSVRRLLF----D--QD-L------------PSS--
SRRFERDPCIL-----------AQER FW---AG RYY---WE-VE-V------GDRKAWIL
GVCLESVG-R--E-GR--------------------------------------------
---------------VPKAPQHGLWAVE-L--Y--------KNKFRALSYP-R-----TP
---------------------------------LSPSQPLH---KVGIFLDWDAGEISFH
NVADSSL--VYTFHGLTF-S-GPLQPFLCLWTHDPR-------PLTIC-SVV-RKTQE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFIWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCKENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNISF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDC
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYNLSGA---VASFLFIL
LTMKQSEDFRVIGPAHP-ILARVGEDALLTCQLLPKRTTMHMEVRWYCSEPSTPV-FVHR
DGVEVTEMQIEEYRGRVEWIEN-GIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSL
LLK VAGLGSAPNIHME---------GP---GE---------------------------S
GVQLECTTRGWF----------PEPQ---VY---WEDIQGEKL-----------------
-LAMSEHHIQDED--------------------------------G------------LF
YVEATLVVRNAS----------------------------------AESVSCLVHN----
PVL TEEKG------------------------------SVI--SLPEK-LQTELAS-LKV
--------I-GPS -QPILVRVGEDIQLTCYLSPKANAQSM-EARWVRSHR-Y---P-AVH
VYMDGDHVAGE----QMAEYRGRTVL-VSDAIDEGRL-TLQILSARPSDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGQEDG-EM-Q---P--MCSSDGWFPQPHVPWRDMEG-NTIPSSS-------
--------------------------QA-LTQGSHGLFRVQTLLRVT-----N--ISAV-
DVTC-SISIPF-LGE-EKIAT-------FSLS-KSRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------T
F---------L---------------------WKTLLVWGL-LLAVA-------------
V-----GLLRKRR-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESA------AALHFS-----RPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------SMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GVAPALK-------
--------------------------EV-SMPDADGLFMVTTAVIIR-----D--KSVR-
NMSC-SINNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCAVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILMIP-----IAV--C
I-----YWINKLQKEKKI-LSG--------EKEFERETREIALKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEE----EL----------------------------------------
-QV---KEKLQEELRW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--CPFR-HLGES-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KGQYRAVSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRLGCEDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------KK---GFLKS-----SHLSFGFS--PR
DDFFGLLV-------------------------------------------HFTAW-FQV
--------V-GPG-VPVAAMVGGEIMLPCHLSTPMSAASM-EVLWYRTQH-S---P-FVH
LYLNGTDNAHG----QMPEYRGRTEL-SKAGMANGSV-ALRLRGIRASDEGQYTCF--VR
-S-S--SFYADA-TLE------L--T-VA-----GVGSSP-----------------FI-
------SVEDYHLG-GI-R---V--VCRTAGWYPEPEMLWKDPRG-QLLLP-L-------
------S-------------------ET-KSKGDSGLFEIQTSIIVK-----R--NTHQ-
NLTC-CVQSQR-LNQ-EKEA----T---IHIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRV--S----------------P----EVV-CLYLLLSIL-----FFSVLALC--
V-----LKRKVKRFA--Q-------------------------SRSRSGEAGPKHL----
-----------EDNGTASELVLRA---WIWDDR---------------------------
------------------------------------------------------------
--------------------TL--------------------------------------
--------PRGRARP------LRGQ-----------FSLSPHAAKVT---L--D-AETAH
PELV----------VH-----QDRKSVRLGSE----R--QN-L------------PDV--
PQRFDTFRCVL-----------GREGFT---AGRHY---WE-VE-V--GP---GGRWWAV
GVVKESVA-R--K-GW--------------------------------------------
---------------HKWTSAMGIWAVQ-H--R--------GSFLQAYTNP-V-----TR
---------------------------------LTVNGNPR---KIRISLDYEGGQVAFF
NAEKNTP--IFSFPTASFHG-EKLFPFFWV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GP---CFY--------GHC------IV
MFLLH-MI------------------------------------------TPSSEK-FMV
--------T-GLE-GPVVAPLGGNLELSCQLFPSQDAQHM-EIRWFRHHY-T---Q-PVH
LYRDGKDIYGE----TILKYVERTEL-LKDAIGEGRV-TLRIFNVTVDDDGPYHCV--FK
-D-S--NFYEEH-ITE------V--K-VT-----G-FYEF-----------------TF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------LGSVP-----------------HV-
------HMTGPKES-GI-Q---V--LCSSSGWFPKPKVQWTDTAG-MKLPS-L-------
------P-------------------ES-HTQNKDGLFHVDSSLVVM-----D--SSLG-
NVTC-SIQNPL-SGQ-EKTST-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKA--S----------------V----WKS-ALAGT-LPV-----LGLLLIGI--
S-----YIGWREHQAKEKEKK--------KMEIEAHE-RVQMTNEKESV-LKTK------
------------EE-----LKADLE-----QRKALY--NK--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EHFKP-------------ASVI---L--N-HQMTQ
SNNS----------DP-----KSK------ENRR--EETRE-L------------PPSDE
--QGDGNLITL-----------KQEPFV---SGRHY---WE-VD-VENAA------GWTA
GICEVHRD-G--N-GS--------------------------------------------
---------------SKEPSRKKFRVLV-K--K--------GDEYKALACCSKSISLDTY
---------------------------------VSIEKCPH---KIMLFLDYGDNDISFY
NMTDGTH--IFSFTQSNF-S-GLLYPYFKLRSME-L-------APSAQ-C----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LK---ILTSL-----KNPLINFK--IL
TSLKNALV-------------------------------------------PFAAR-FSV
--------I-GPD-HPVTAVVGGHIVLPCHLSPNMSVENM-EVRWFRHEF-T---P-FVH
LYRHGEEEFGQ----QMPEYHGRTEL-LTDGIADGNV-DLVILNVRPSDEGQYRCS--VQ
-D-G--DFQEEA-VLE------L--E-VA-----VSGSAP-----------------QI-
------SMEGYQDG-GI-L---M--VCHLAGWYPEPEVLWRDLSG-QLLSS-S-------
------V-------------------ET-KSRDAQGLFEIKSSLVVT-----E--RSNQ-
NVSC-SVRSAH-FSL-EKDPS---T---FYMS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRA--S----------------P----WMV-GWSVT-LVI-----LLPFVCLA--
S-----FLFRLTGSKCDGSES--------SPR--VRERKE----SRDQ----TKEF----
--------K-S---RIQETSKLQD---FQYKGG---------------------------
------------------------------------------------------------
------------------------------------------------------------
----------RAHQGR-A------------------SCDHVTDTNVT---L--E-ADMAH
PWLI----------LS-----EDGKRVRWRCT----Q--QP-L------------PNT--
PERFDNWFCVL-----------GRKGFI---SGRHY---WE-VE-V--GN----GPCWAV
GVSRESVS-R--K-GE--------------------------------------------
---------------ISLSPEGGIWAVGRR--W--------GDQFQALTDP-V-----TP
---------------------------------LPLS-PPS---RIRVCLDCDRGQVTFI
DAGTEAP--IFTFPPGSLPG-ERIRPWIRV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------SL----------VFHLLHLPVC
LALVQ-------------------------------------------LLTPCSAE-FAV
--------I-GPP-EPILSMVGEVAELPCHLSPKMSAETM-ELMWLRSGL-R---Q-AVC
AYGDGKEE--T----EIAEYRGRTSI-LRENIAEGKA-ALRIHKVRVSDSGTYQCY--FQ
-D-A--DFFAKA-QVE------L--K-VA-----ALGSDL-----------------HI-
------EMKGYEDG-GI-R---V--ECTSAGWYPQPHVEWRGDGG-ESLPAM--------
--------------------------AAPGAADGEGLYAVTSSVILE-----G--GSGK-
GVSC-VVRNPL-LSQ-EKTAR-------LSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FSNT--K----------------P----WQV-AVWVT-LLA-----LLGLLAGA--
V-----FTWCRQQKRIWVL---------SQEKEREEAEKQQEWSAKE-------------
----------------K-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------LL--------------------EELKWKMALYQPADVI---L--D-PDTAH
PKLL----------IS-----EDQRSLQYIHT----W--QS-L------------PDN--
PRRFQDRSCVL-----------GRESFT---SGRHF---WE-VE-V------GDRKHWQF
GVCRENVE-R---KYH--------------------------------------------
---------------PPVTPQNGFWTISLF--N--------GHDFQAQTDP-R-----SK
---------------------------------LTVVKPPK---RVGVFLDYESAEVSFY
DAIDGSH--IHTFSQASF-S-GPLLPLFWIWSQETT-------ALTIC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MSAENM-EVRWFRTDF-S---S-LVH
MYRNGKEETDA----QMPEYVGRTDL-LRGGLRDGRV-ALRLRNVQPSDEGRYACY--FQ
-S-V--SFYSEA-PLE------L--R-VA-----ALGSTP-----------------LL-
------SVEGYQDG-GI-R---V--VCRSVGWYPEPQVSWRDVAG-QQVPP-L-------
------S-------------------ET-KFQRDGVLFGAETSILVT-----P--LANQ-
NVSC-SVGNSR-LGQ-EKGS----A---VYIA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPKE--S----------------P----WIA-VLCTL-LVV-----QLGVIGFL--
I-----YFFTTKGPQKRRSTL--------ICREEGRRT----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------PTFNERC-L-------------------DILPHKADVT---L--D-PDTAN
PYLI----------LS-----AD----------------QK-P------------PTR--
PKRFVYSPCVL-----------GQEGFT---QGRHY---WG-VD-V--GR----RGGWAV
GVARESVS-M--GQDE--------------------------------------------
---------------VSLKPDAGVWAIERQ--W--------WGKSWALTNS-K-----TP
---------------------------------LELSRNPQ---RIRVSLDYEAGLVEFF
DADQAKP--FCVFSPGSFGG-ERLFPFF--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
FLLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPT-DPILAMVGENTMLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYSCY--FQ
-E-G--RSYDEA-ILL------L--M-VA-----GLGSKP-----------------LV-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-STPAADGLFMVTTAVIIR-----D--KSVR-
NMFC-SISDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPWVVALLV----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILIIS-----IAI--C
I-----YWINRLQNEKKI-LSG--------EKEFERQTRENAVKKLE-------------
------------------------------------------------KKHVQ-------
------------------------------------------------------------
-----------N------------------------------------------------
-------LQVKGKRGW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLWES-V------------PDN--
PERFDSEPCVL-----------GRES FT---SG KHY---WE-VE-V------ENVIEWTV
GVCKDSVE-R--K-GL--------------------------------------------
---------------VSLLPENGFWTLDMR-----------KGQYRALSSPKT------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLILHRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SQD------------SLPSS------LFFLTHLLL--
--LLQSGE------------------------------------------L--YSE-VSV
--------V-GPG-DSILAHIGDEVEFLCHLSSYRDAEDM-EIRWFRSQA-S---D-VVH
LYQEGQELYDQ----QMKQFQNRTEL-VKDDITDGSV-TLHLYSVIPADEGPYGCR--FL
-S-S--DFSGEA-TWE------L--E-VV-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPMPLAQWRDHHG-RCLPP-E-------
------T-------------------ED-IIQDAQSLFSLETSVVIQ-----G--GTQS-
NVTC-SIQNPL-LGQ-KKEFA-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRT--S----------------P----WKR-AFLGT-LVG-LLLLLALLLKLV--
L-----YIFQKQRRSQEKLKK--------QAEK-DKG---KL--RAE---L---------
-----------------GKLQVEL----DWRRAEGQ-----AEWR---AAQQYA----VE
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PGSAH
PSLE----------VS-----EDGKRVSS--RRM-AP--GL-A------------AGH--
HQQFLEQTCVL-----------SQQR FS---AG RHY---WE-VH-V------GHRSRWFL
GVCLAKVQ-C--S-GP--------------------------------------------
---------------VLLSPANGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALTMHVPPR---CVGIFLDCDAGKLSFF
NVTDGSH--IFTFTDTF--S-ETLCAYFRPRAHDGS---KHPDPLTIC-PLP-VRES---
----------SDNWLQ----------------------------S---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------EMKGSPVLP-----LA--------RCLLPL----
--LLLVST---GVS-------------------------------------GEVSQ-FSV
--------R-GPA-EPIMVLLGTDATLPCQLSPVQSASGM-HVRWYRAQL-T---P-AVL
VVHDGQEQEDV----QMPEYRGRTQL-ARDAIATGNV-ALQIQQVQASDNGLYHCQ--VT
-Y-G--FTSQEA-TVE------L--H-VI-----GLGSAP-----------------LV-
------RMTGVETN-GI-R---V--SCSSSGWFPKPTVQWRDTQG-NILPS-S-------
------S-------------------ES-QAQDRDGLFRVETSLLVT-----D--RAVG-
DVIC-FIQNPL-HDQ-EKAKT-------ISLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRN--S----------------P----WRT-ALACL-LPI-----LLVLFSGT--
S-----LACWKEHRAKRREMD--------KNSEEWHK-MNQMSQEMKTA-LKNR------
------------DE-----LQADLD-----RRKALY--LE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQL-------------APVM---I--N-HEVPH
QDKS----------GP-----KTE------ESSR--EETAD-P------------SLSNP
--QVDHNIITL-----------YQEGFM---LGRYY---WE-VD-IGDTE------EWTL
GVYELYTQ-D--A-P---------------------------------------------
----------------PRDSVKKFRVLE-K--K--------GDKYRALTFCSQNVSREEA
---------------------------------LLLDTRPL---KIAIFLDHEDNDLSFY
NMTDETH--IFSFTQAGF-Q-GSLYPYFKHNRMD-L-------SPSQS-Q----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MV---
--------------------------------NFPD-TFLPSC------LI---SL--LL
LLFLKLPT-------------------------------------------LGSAQ-FAV
--------I-GPA-KPILAQVGGEAELPCQLDPTVSAEDL-EVRWIRSQS-S---D-VVH
LYEKGEDQLKE----QMEEYRGRTEL-VRDTIATGCV-SLRISNVTVFDDGDYRCL--FI
-D-G--FFQNET-NLE------V--Q-VA-----AVGSDP-----------------LI-
------HLEGHEKG-GI-R---L--GCTSTGWYPEPQVHWRDVRR-ETIPS-L-------
------S-------------------ES-RPQASDGLVGVVATVIIQ-----E--DSAG-
TVSC-SIRNTR-LGQ-EKRTE-------ISIV-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
L---FPRT--N----------------P----WKI-TTIVI-LSI-----LGLFLGNC--
G-----LVFWQNLCRKERQKQ--------N-QQ---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------AFQT------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--GL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTL
--------N-SLE-RPVLAALGGNVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--DVYEEA-IAE------V--K-VT-----ATSLEV-----------------QI-
------LIHPPNIK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDGNKLFNMKMSLLLR-----D--SSHG-
NITC-YLRNPI-TGQ-EERTS-------IVLS-DKLFS-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---MCVIIGLTITLHHR---------------NRVPVSDR
K---FQLV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGFF--------------QI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MKILSSY
---ES---------------------------SRAR-SCLA-H-----------FI--IF
SLTCYVHK-------------------------------------------LESAQ-FTV
--------V-GPG-RPVMATLGGHIVLPCYLSPSMSAQDM-EVRWFRREF-T---P-FVH
LYRRGADEFGQ----QMPEYHGRTEL-LTDGIMDGNV-DLGILNVRRSDEGQYHCS--VQ
-D-G--DFREEA-VLE------L--K-VA-----ALGSAP-----------------CI-
------SVEGHQDG-GI-R---V--VCQSAGWYPQPQVLWRDPNG-QPLSA-S-------
------I-------------------ET-KSEEEGGFFKIKDSIVIT-----E--NSNK-
NLSC-SIRITH-MDA-EKQSV---T---FYIS-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
L---LPKP--H----------------S----VIP-TRIKN-QVA---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------LH----
LSSFLSPM---SLS---------------------------------------TED-FMV
--------I-GPS-EPIVAVLDGDITLPCCVSPAMDVENM-ELWWFRSKF-S---E-AVL
IYQNQREQREE----QLAQYRGRTSL-VKDFLTQGDA-AVLIHNVQAFDNGLYTCF--FR
-M-G--IFYEEA-SVE------L--K-VA-----GVGSAP-----------------QV-
------HITGPEED-GV-Q---V--VCMASGWFPKPQVQWREVPD---------------
------V-------------------ET-QAQDGEGLFTIETTLVVR-----D--SSSG-
NVTC-SVLNPI-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRS--S----------------P----WKL-AFMVI-LTV-----LMLLLLGA--
V-----FYIMREHTTKLQEMQ--------EWEKLHRE-KEEDQRIKEEA-LKAR------
------------DE-LQ----GDLD-----WRKSVY--L--AALK---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-WK------EKFQA-------------LSVS---L--D-PESAH
SSLA----------IS-----DDKTSVTFKDSPK--D-----------------------
--T-GETYSVL-----------GHEDIT---SGCCY---WE-VE-IRNAEEKS---EWAL
GVCRRGVE-R--K-GW--------------------------------------------
---------------YQECPGKGFWVVG-V--Y--------ENKVFS--LPDN------S
---------------------------------ELLVPVPQ---RVGVFLDLKEGDVSFY
NMTDGSH--IFSFPLASS-S-EILFPYFG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
----------------------------EM-ASSS-----G-----FWLSGCLT-----A
LVFLRLPV-------------------------------------------PL-SD-R--
--------T-GDADDYHLAPLGGTAQLLCPLALWPVTVPT-VVTWLRSPRPD-GSQ-VVH
VFRDGRDREEG----VMPEYKGRTAL-LRDP-REGSV-SLEIRHVRLEDRGPYRCE--VQ
-I-G--NVTREG-TVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-Q---L--VCRSAGWFPQPL-AWRDPQG-RVLRPLS-------
--------------------------DG-HVL-EAGLFRIAVSGRVR-----D--STLG-
NVSC-TVRNLA-LGQ-EKTTA--------------------------------MLI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
I---S-----S---------------------SA-VALAVV-LPV-----LGVLIIVG--
V-----FLIWKQRRSKEKLLYE--QVVEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------SKFHSSSEL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDQRCVKLGDR----R--QP-V------------PDG--
PQRFDFVVSVL-----------GAEYFT---AGCHY---WE-VD-V------GNKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTATPANGHWLVRQS----------SEKEYEALTSPQT------T
---------------------------------LRLKEPPR---CVGIFLDYEAGIISFY
NVTSRTH--IFTFTHTF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKSEPSA
GCEP---------------------------------------------------EEKG-
-HANGDVAMNVDPS---LFPPQAPEL--FPPG---DMILPWPSDLAPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
----MQIA--R----------------K----WKT-VRVQ--------------------
R-----W--HHCREYCSPN---------IQCYKRERKMREMGLCLKG-------------
----------------EWSV---------EKNKNT--------------DLFLI------
----------------------C-------------------------------------
------------------------------------------------------------
---------VS--------------------FLSEWKMALFKPAYVI---L--D-PDMAN
AILL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PERFEWRYCVL---------------------G RHY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYQ--------------
--------------------------------------------KVGIFLDYETGEISFY
NATDGSH--IYTFLHASF-S-EPLYPVFRILILEPT-------ALTIC-PTP-KEVESSP
D---P--DL----------------------M-PD--------HSLETPVT------PGL
ANESGEHQAEVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MPWVLMEPA------AALHFS-----LPASLIL-----
LLLLRLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILTTVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-FTPDADGLFMVTTAAIIR-----D--KSMR-
NMSC-SINDTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKEKKI-LSG--------EKEFELETRETAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----EL----------------------------------------
-QV---KEQLQEELRW--------------------RRTVLHAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVKR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLDMH-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPMRPFFRIGSDDSP-------I-FIC-PAL-IGASGVT
VPE--------EGLTLLRVGTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------SL------------SL--------SLSLPP----
--SLSLTP---TAL-------------------------------------VNVSR-FSV
--------K-GSA-VPLRVLLGADATLPCQVFPPQSVAHM-HIRWYHTQL-S---R-AVL
VFQNGQEQRQE----QMPEYQGRTRM-LGDAIAKGSV-TLLIQQVRASDSGQYWCH--FT
-D-G--ATSQGA-SVE------L--H-VI-----GLGSAP-----------------RV-
------RMTGLEEN-GI-R---V--LCSSSGWFPKPKVQWRDSAG-VTLPS-P-------
------A-------------------ES-QTQDSNGLFHVETSLVVT-----D--ETLG-
SVTC-SVQNLL-YGQ-EKASA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRA--S----------------P----WKV-ALIWT-LPL-----LTLLLLGA--
I-----YVGWRDHKANKREIK--------EKEKESNR-TDQIKKDMELA-QQTK------
------------GR------------------------LW--------------------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-KK------AWLYP-------------APVS---I--Y-RGALH
QDNP----------DP-----KAE------ENRR--EET---------------------
--REDTNLITL-----------HQEGFV---WGRWY---WE-VD-VGNTE------EWAL
GVYELSTF-G--D-IS--------------------------------------------
---------------LNKSSEKKFSVLE-K--K--------GDTYRALTFCSNNISQEEC
---------------------------------LWVENHPQ---KVAIFLDDIDDDLSFY
NMTDDTH--IFSFSQACF-PLSLLYPYFTCKPLD-F-------SSQP-------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
--------XGE----QLVDFKGRAEL-VKDYITEGRV-AVRIYGLRISDNGIYKCF--FQ
-K-G--SDYEEA-SLE------L--K-VI-----GLGSGP-----------------RV-
------FMVGPEDK-GI-R---L--TCTGKGWFPQPEVQWTDARG-EKIPS-L-------
------S-------------------ED-ENQDDDGLFQIEASLIVR-----D--SSKT-
EVSC-SMKNPF-FGQ-EQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WKG-AFAGT-FLL-----LGIFLSAV--
V-----FLAWKERQEKKRVQE--------V----QKE-KEKESEAKE-------------
------------------LLKKELD-----RRKEL---YQ-RDWR---KAKLY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------EQFKAV-------------AVT---L--D-SERTS
GSLI----------IS-----NNKKQVSL--NVP--Q-DGD-A------------SVYQG
KEESEAVLSAL-----------GQNSFE---TGRYY---WE-VE-VNIGTEAGPETKWAV
GVCLDSVT-R--D-GW--------------------------------------------
---------------FVESPEKGFWVLA-Y--K--------EGEFKVP-IAS------ES
---------------------------------LSPRQHHQ---RIGVFLDQEDGDLSFY
NMLDGSH--IFSFIGITL-H-QTLRPYFSLQGAG-T-------SVTIC-TTS-DDTDNYP
DSSP----NISVTHLR--------------------------------------------
-SG-DMGVPQEANH---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLLL--LL
LLLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-NPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRITF-VSKDINRGSV-ALVIHNVTAQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRDPYG-EVVPALK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KYVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------SASPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTA--S----------------P----WMV-SMTVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKKVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRHSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-T-VPVRPFFRLGSDDSP-------I-FIC-PAL-TGASGVM
VPE--------EGLKLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MARI-GSGA-ASLPRS----LVF---LVF--LK
LLPLA----------------------------------------------IGKAD-FQV
--------L-GPQ-QPVLAVLGKDAELPCWLSPNISAHLM-ELRWFREQP-S---P-AVH
VHHAGQDKIGE----QMPEYHNRTSF-VDLDMAQGKA-AVRIHRVTASDNGSYHCL--FK
-E-G--RAQEAA-TLW------L--Q-VA-----GVGSKP-----------------RI-
------QVIHTQDR-GV-W---A--ECTSDGWYPQPEIKWKGQTL----PN-E-------
------T-------------------KF-SVSANTSLWAVVSRVALQ-----D--GAVD-
SFSC-SISNTL-LSE-EKVL----VLSRCFRP-L--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
H---LTRS--Q----------------L--RKQRL-ALAFS-LLA-----MGLIMAGV--
I-----YLFGNCQRKAYRTQL--------TEETEG-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GR-D-------------------EQTH-----P---W--T-LTLQV
SKLT----------VS-----EDQKSVRWLLF----N--LD-Q------------TPS--
SKSFEEDPCIL-----------AQELFW---AGRYY---WE-VE-V------GDRKAWIL
GVCLESVD-Q--V-GR--------------------------------------------
---------------VPKVPQHGLWAVE-L--Y--------KKKFWALSYP-R-----IC
---------------------------------LSPSQLLH---RVGIFLDCDAGEIAFH
NVADDSL--MYTFHGLTF-S-GPLQPFLCLWTHDPR-------PLTIC------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------SIS-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPSG--L----------------S----LLV-ALGVT-LPV-----LGLFIAGG--
L-----YFFWKQHRDKGKGSR----------------------------------PD---
-GFFSE--------------------------KLQV--E--LRWS---LFQL--------
------------------------HEA---------------------------------
------------------------------------------------------------
--------------------------------------------SIT---L--D-PESAH
PNLL----------LS-----EDQKQVIVGFT----R--QD-L------------PNK--
LERFSHDWCVL-----------GREHFT---SGRHC---WE-VE-V------GEKTGWEV
GVCRENVR-R--K-MR--------------------------------------------
---------------ISTLPEHGFWTLE-K--Y--------GDRYWARTSS-R-----PR
---------------------------------LLLTTRPL---RVVVYLDYEAGDVSFY
SGTDGSH--IYTFSHAAF-L-GTLRPFFWLRSSGPA-------PLTIC-PVH-GGAGGDG
AGGD----L------------------------VP--------VPSQDTSMTPPGEGPAS
ASGDSHPLHEADAP---LLATKTSPG--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GHPSL-----TSHVRGLL--TF
LITLLLLR-------------------------------------------LGSAQ-LRV
--------V-GPG-HSVTATVGKDVVLPCHLSPQRDARNL-DVRWMRDEF-S---E-TVH
HYRNGEDLYGE----QMGTYAGRTEL-ARDGLSAGSL-DLRITGLRPSDDGLYICN--VK
-N-A--DGYAEA-IVE------L--E-VS-----ATGTDP-----------------HL-
------SLGGYEAG-GV-R---V--LCRSAGWYPLPQLLWRDARG-QHLPS-V-------
------S-------------------QT-HSQDQEGFFEIEGAVIVT-----G--SVEG-
PLSC-VVRSSR-LQQ-ERES----S---LHIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FHNA--Q----------------P----WMV-ALAL-VLVL-----LAVSIGLG--
V-----YLFRKQXAQSRELGE--------SLQSLPPA-----------P-----------
--------------G-EVVSVREG---LVWSYTKSI--V--QSWT---SIFVVP----PW
N-----------------------------------------------------------
---------------KA-------------------------------------------
--------VLSQ--SW-EK-------------------QAAELVKVT---L--D-PDTAH
PLLV----------VS-----QDNSSVRLESE----L--QQ-I------------PDT--
PERFLYCWCVL-----------GHEEFR---EGRHC---WL-VE---AQGERLKYSGWAV
GVARESLE-R--K-KW--------------------------------------------
---------------IDMSSEEGIWAVQ-Y--D--------EGKLKSLTSP-P-----TP
---------------------------------LSLSHVPT---RIWV------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAM-ASSS-----G-----SRLSSCLI-----T
LIFLQLPL-------------------------------------------RV-S-----
----------GDASNVHSAPLGGTAELPCPVSLWGVTALP-AVTWLRSSPSG-SSQ-AVH
VFRDGQDREEE----VMPQYKGRTKL-VRDA-QEGSV-TLEIRDVQLEDRGLYRCQ--IQ
-V-G--NLSREG-TVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGFDTG-WI-Q---L--VCRSVGWFPKPWAQWRDPQG-RVLPSLS-------
--------------------------EA-YSLDEAGLFGTAVSSKVT-----D--TTLG-
NVSC-TIRNVA-LDQ-EKTTA--------------------------------MVI----
------------------------------------------------------------
-----------------------------------------------------AAPSPGS
L---S-----S---------------------SA-VALAVI-LPV-----LGLLIVVG--
I-----CLIWKQRRSKEKLLYE--QAVEVE-NLLTGHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRQELKV-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVKLGDR----R--QP-V------------PDN--
PQRFDFVVSVL-----------GSEYFT---AGCHY---WE-VY-V------GDKTKWIL
GVCSDSVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------QGNEYEALTSPQT------C
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHTF--S-GPLRPFFEPCLHDEG---RNMAPLIIL-SEL-QKSEESI
VPKP---------------------------------------------------EEKG-
-RANGDVALKVDPS---LLPPQTPEL--LPLK---DMILSWPSDLSPALQGLNVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------CTLTL-LSLLVP------FQ-FN------
--FLFPLA-------------------------------------------HFTEQ-FTV
--------R-GPD-SPVTASLDGEAVLPCHLSPSISAENM-EVRWFRSQY-S---A-VVH
LYRNRQDQYVQ----QMPEYRGRTEL-LKDDISSGRI-SLRIYDVRPSDHGQYTCL--VQ
-S-R--VSSEEA-LLE------L--Q-VA-----GMGSDP-----------------DI-
------SLEGHRDG-GV-Q---L--GCRSSGWYPQPEAEWRDQQG-QLLPS-A-------
------S-------------------ES-SSQAAGGLFQTEIATVLT-----D--MSNQ-
KVSC-HVWNPR-LDQ-GRESA-------VSVA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPKD--N----------------P----WMV-PLGVI-LPL-----LAGLIALA--
S-----YCYWRQHQGKGKPEH--------K-VGEER------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLLL--LL
LLLLSLCA-------------------------------------------LASAQ-FTV
--------V-GPT-NPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRITF-VSNDINRGSV-ALVIHNVTAQENGIYCCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRDPYG-EVVPTLK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KYVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------SASPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTA--S----------------P----WMV-------------------------
I-----CCIKKLQREKKI-LSG--------EKKVEQEEKEIARKEFP-------------
------------------------------------------------FLNYS-------
------------------------------------------------------------
-----------VYNLCSAYL----------------------------------------
-AVSHDLHLCLSLAGW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRHSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-T-VPVRPFFRLGSDDSP-------I-FIC-PAL-TGANGVM
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MLKLLKKH-V---------VAWK--------------------------------MCVMP
HSRK-------------------MSVHMERP-SPR-----G-----SWLVGCLF-----T
IAVFQPPV-------------------------------------------QV-------
--------S-GDAGKVYIAPLRDTANLSCPLFLWPNMVLS-EMRWYRPGHLPRT-Q-AVH
VFRDGQDRDED----LMPEYKGRTAL-VRDA-HKESY-ILQISNVRLEDRGLYQCQ--VW
-V-G--NSSRED-NVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WI-E---L--LCQSVGWFPKPWTEWRDTTG-RALLSLS-------
--------------------------EV-HSLDENGLFRTAVSSRIR-----D--NALG-
NVSC-TIHNEA-LGQ-EKTTA--------------------------------MII----
------------------------------------------------------------
-----------------------------------------------------GAPERGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLLILLG--
I-----WLICKQKKSKEKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVRLGDR----K--RP-V------------PDN--
PERFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGIFLDYEAGIISFY
NVTDKSH--IFTFTHSF--S-SPLRPFFEPCLHDEG---KNTAPLIIC-TEL-QKSEESI
VPKQ---------------------------------------------------EGKD-
-RANGDVSLKMNPS---LLSPQGSEL--FLLN---DT---WPSNLGPALKGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDCRRG-------------SLLSRLTSL----
LLFFQLPA---GGS---------------------------------------VEE-FVV
--------V-GPS-DPIVAVIGGNVTLPCHVSPAMDVENM-ELRWFRSKF-S---E-AVF
IYENQQEQKEE----QLAQYTGRTSL-VKDFLSQGEA-TVRIHKVQASDNGLYTCF--FR
-K-G--SFYEEA-SLE------L--K-VA-----GVGSVP-----------------QV-
------HITGPEED-GV-R---V--VCTASGWFPKPQIQWRAANG-EKFLT-F-------
------S-------------------ET-HAQDTEGLFSVESALVVR-----D--SSSG-
NMTC-SVLNPV-LDQ-KKAMT-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKP-AFIVS-LVV-----LMLSLLGA--
A-----YYIKTEHTVKRQEMQ--------EWERLHRD-KEEARRTKEEA-LKAR------
------------GK-AA----QE--------PRVCP--F--SGWR---KALLYA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VSVT---L--D-PASAD
PHLA----------VS-----GGQTSVTLENTTE--D-----------------------
--P-EGPCSIL-----------GQEAIT---SGRCY---WE-VE-IRNGN-RS---EWSL
GVCRGDVD-R--K-YW--------------------------------------------
---------------YREWPVEGFWVLR-W--C--------RGKFCAFLLPES------Q
---------------------------------EIGDEVPH---RVGVFLDLKEGDVSFY
NMTDGSH--LFSFPLTSS-T-GTLFPYFMIQSGD-V-------SLTIC-SVV-GVPTETP
VPLN----N------------------------PP--------SSLEEPVSLSG-DGFSS
GSAVDGALPGADSP---LLSYGPEVS--PG------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------KMVVSADYS-----P-------A-GFFLLL--LL
L---QVST---WCS--------------------------------------AASR-FSV
--------K-GPA-EPIMVLLGADATLPCQLSPEQSAAHM-HIRWYRNQL-S---P-AVF
VYQNGQEQGGE----QMLEYRGRTEF-VRDSINKGGV-ALLIQHVRASDHGQYWCH--FM
-D-G--QSSQEA-IVE------L--H-VI-----GLGSAP-----------------HV-
------RMMGPEDG-GI-R---V--LCSADGWFPKPRVQWSDMMG-VNLQS-L-------
------S-------------------EF-QTQDEDGLFCVEASLVVT-----D--SSLG-
NVTC-SIQNPL-SGQ-EKASA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRM--D----------------P----WKA-ALAGT-VPV-----LMLFLLGI--
S-----YTGWRKHQAKEREVK--------KKQRESRE-RYQMENEKERA-LKAK------
------------EN-----LKAELE-----QRKALY--LRVLDWK---KAWLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------EKFQP-------------ANVT---I--N-QEI-H
QNNC----------DP-----ESK------ENFR--EETQD-L------------SLSDK
--RGDCNLITL-----------NQEDFT---SGRHY---WE-VD-IKDTD------EWTL
GIYEKLTG-K--S-GL--------------------------------------------
---------------STKLQKKKFRVLE-K--K--------ECKFRALICGPQDISLKKD
---------------------------------LKIEKYPQ---KIVIFLDYEDKDISFY
DMTHGIH--IFSFTQESF-T-GSLYPYFNIKSME-Y-------SLYEQ-Y----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEDLSCCP-----V--------LCRLTPL----
LLLIQLLT---GGS---------------------------------------LEE-FSV
--------L-GPS-DPIVAVLGGDAVLSCRVFPAMNAEDM-ELRWFRSKF-S---E-AVF
IYQNREEQSEQ----QMGCYAGRASL-VRDLLSQGEA-AILIRQVQVSDNGLYTCF--FR
-K-G--DFHKEA-SLE------L--K-LA-----GVGSAP-----------------EM-
------RITGPEED-GV-R---V--LCTVSGWFPKPQVQWRDGSG-EKFL----------
--------------------------------DAEGLFSVEAALVVR-----D--RSVG-
NVTC-SVLNPV-LGQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKV-AFLVS-LTV-----LMLLVLGA--
G-----CYIRREHSIKLREME--------EKRHLWQA-KEEARQTKEKA-LQDK------
------------GE-AG----QQP--------RVCS--L--SGWK---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------AF------------SAE-------------PVT---L--D-PGSAA
SSLV----------VT-----HEKTSVTRKN-TG--V-----------------------
--NPGDMDSVL-----------GFEDIS---SGRWY---WE-VE-IKDGD-GC---EWAL
GVCRKDVK-R--E-GW--------------------------------------------
---------------CKECPEKGFWLVG-K--Y--------SDKYFVHTAQYT------E
---------------------------------LSLRQFLH---RVGVFLDHEEGDVSFY
NMTDGSH--IFSFTGVSF-S-GALCPYFKLRAGD-V-------SLTIC-SKV-GGSEGLP
VPLN----D------------------------S----------CLEGPVSLPG-EEISS
GSGADA-PPGAESP---LLPCNPEAV--SP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------SLS--------AYC--------
--------------------------------------------------PAVSLS-FTV
--------T-GLT-KPVLAPVGGTLELSCQLSPPQDAQHM-EIRWFRNRY-T---Q-PVH
LYRDGKDLHGE----TIPKYVERTEL-LKDDIGEGKV-TLRIFSVTVDDDGPYHCV--FK
-D-G--EFYEEH-ITE------V--K-VT-----ATSSDI-----------------QI-
------LLHPPNTK-GV-M---L--ECHSGGWFPLPHMEWRDSKG-EVIPE-T-------
------S-------------------KS-HSQDGNKLFNMTMALFIN-----T--SSYQ-
RVTC-YLQDRQ-SLQ-EESTS-------IILS-GELFA-------WKSVWIWILSMITFM
LIP-FLMTSCAHQ-HFIRDRF---------------------------------------
---SVKNYPWIKSAMAFLGS---MVEIIGVILILHLN---------------QRV--SDS
Y---FELD--T--------------------FWL-EDISV-IFFV-LIV-FKIKLI-S--
F-----IYFRLKGKY--------------DGNGDCSK--------DLVHVT---------
------------------------------D-----------------A-----------
-------QMSRRCPSVL-----VSIRKI------------K-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEHGCRP-------------SLLCSLPSL----
LLLAQLPT---WGS---------------------------------------ADE-FQV
--------I-GPS-EPIVAILGGDAILPCSLFPPMNAEDM-ELRWFRTKF-S---E-VVF
VYRNRREQHKE----QMPQYAGRVLL-VQELLTQGQA-AVHIQKVWASDNGTYTCF--FQ
-K-G--GRYAEA-ILE------L--Q-VA-----GLGSVP-----------------QV-
------HIEGLEQD-GV-R---V--VCKALGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ--KAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-ALVAV-ETQ-----TGQLEAGA--
V-----CGSGVKNFSRIQAEL--------GVVR---V-QDRSERSKCEH-RGQG------
------------GLSRW----CGCG-----LTRMCF--L--SAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ERFQAW-------------SVT---L--D-PGSAH
HSLA----------VS-----PEKTSVTCIY-TG--V-----------------------
--GWDNTCSVF-----------GLEGIT---SGRCY---WE-VE-IRSGK-FS---KWVL
GVCREQVS-S--T-DW--------------------------------------------
---------------YTESPDEGFWVVG-W--F--------YNRYLAWTKP-L-----EL
---------------------------------LSLRQHPF---RVGIFLDYAEGFVSFY
NMTDGSH--IFSFPPASF-S-GTLFPCFLLK-GD-V-------TLSIC-STE-GGSEG--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MLNVL--ALLCPI-Q--VFHNFEHHF--LL
ISILSLI-------------------------------------------ELASGQ-FQV
--------I-GPN-NPIQALIGEDVLFSCHISPKMNVKNM-EVRFFRNQF-S---S-VLL
LYKDGKEIDER----QMQEYQGRTQF-MQDAITEGTV-SLKLKNIVSSDMAKYGCW--FS
SK----TFYEEY-TWE------L--Q-VV-----ALGSTP-----------------LI-
------SLEGNRDG-GI-L---L--VCQSSGWLPQPKIQWRYDPD-QYLLLNY-------
---------------------------T-VNQDDHGLFSIKTTLTIK-----E--HSNK-
NISC-LVLNLA-LGQ-MKESR-------LQIA-GEVSPLSC-------------------
------------------------------------------------------------
-----------------------------------------------------------P
LNRCIQAVA-F----------------P----WFL-F----LLFC---TR-PFLFLGD--
-----FISQCHLISA---LLF--------LELM---------------------------
---------------------EK-------------------------LK----------
------------------------------------------------------------
------------------------------------------------------------
--E-----------------------AGKRTTFLSFQILLLHSLEVT---L--D-PDTAH
HKLH----------VS-----EDQKSVTHEDGVI--Y--EDNG------------LEN--
NIRFQ-FPCVM-----------ASQSFS---SGKHY---WE-VE-V------GKMKKWYL
GVCWNDVT-R--E-KEK-------------------------------------------
---------------VMFSPDKGYWILGLW--N--------KSEYFTYTPY-R-----KA
---------------------------------LRFSVEPH---RVGVFINYEAKEISFF
NVNDRSH--IYTFTNCDFKG-KALYPCFCPHKSDSP------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MV---------DFPGY-----NLSGA-VA--SF
L-FILLTM-------------------------------------------KQSED-FRV
--------I-GPA-HPILARVGEDALLTCQLLPKRTTMHM-EVRWYCSEP-S---T-PVF
VHRAGVEVTEM----QMEEYRGQVEW-IENGIAKGNV-ALKIHNIQPSDNGQYWCH--FQ
-D-G--NYCGET-SLL------L--K-VA-----DLGSAP-----------------NI-
------HMEGPGES-GV-Q---L--VCTTRGWFPEPQVYWEDIQG-EKLLA-V-------
------S-------------------EH-HIQDEDGLFYVEATLVVR-----N--ASAE-
SVSC-LVHNPV-LTE-EKGSV-------ISLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------K
L---QTEL--G----------------K----YEV-VAHTC----------GGSLCP---
-------PQQREGSY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------HETM--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MR-----G--SSGE-
RVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DS
F---FTSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLAVA--
G-----YFLWQQQEKKKTL---------SRKKKREQQLREMAWNTMK-------------
----------------QEQS---------K------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------TEWRSIQYTALDVI---L--D-PNTAN
PILL----------VS-----EDQRSVQRAKE----R--QD-L------------PDN--
PERFDWHFCVL-----------SCES FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LTLPESPR---KVGVFLDYETGDVSFY
NAVDGSH--IHTFLDISF-S-EPLYPVFRILTLEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLP
---V-------------------SLDSLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PS-SE--VEV
--------L-GPE-HPILALVGEEVEFPCHLWPQLDAQQM-EICWFRSHT-L---N-VVH
LYQEQQELPGR----QMQVFRNRTKL-VKDDIAYGSV-VLQLHSIVPSDKGIYGCR--FH
-S-D--NFSGEA-LWE------L--E-VA-----ALGSDP-----------------HL-
------SLEGFKEG-GI-Q---L--RLRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GALS-
NVSV-SIQNLL-LSQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---VPGA--S----------------P----WKS-AFVAT-----LPPLLLVLAALA--
L-----GVLQKQRRSREKLRK--------QAEK-RQE---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----EDGKSVSSR---GAPP--GP-A------------PGH--
PQRFSEQTCAL-----------SLERFS---AXXX-------------------------
------------------------------------------------------------
--------------------XXXXWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALALRVPPR---RLGVFLDYEAGKLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIC-PLP-VRGTRVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------TDIVRTL-HGDG-----GC-----SLLM------QD
AL-LLCVL-------------------------------------------LVTAQ-FTV
--------R-GPD-RPLAASLRGVAILSCHLSPSMSAENM-EVRWFRSQY-S---A-VVH
LYRDGQDQYVQ----QMPEYRGRTEL-LKDDISSGRV-SLRIYDVRPSDHGQYTCY--FQ
-S-S--ASYEEA-LLE------L--R-VA-----DLGSDP-----------------DI-
------SVEGHQDG-GI-R---L--VCQSSGWYPQPEAEWRDQQG-QLLPS-A-------
------S-------------------ES-SSQAAGGLFQTQTAMVLT-----D--MSIQ-
KVSC-RIRNPQ-LNK-ERES----A---ISIA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPRV--N----------------A----WMV-SVWVI-LAL-----LAGLIAVA--
S-----YYFWKVYRAKGTPSG--------DGQRGREV-RDGQC-----------R-----
-----------DVETGRSVCPEPL---EMLP-----------------------------
------------------------------------------------------------
------------------------------------------------------------
--------ATQTDFTY-SN-----S-----FLH---------RLDVT---L--D-PDTAH
PNLV----------LS-----EGRKRATYGNT----R--QA-L------------PNT--
PERFDPSPCVL-----------GTEGFT---GGRRY---WE-GE-V--GD----KTEWYL
GVCRESAS-R--K-AS--------------------------------------------
---------------FRTTPSDGYWAVW-L--S--------YGKYQACTSP-L-----TP
---------------------------------LPVSAKPA---RVGIFLDYEAGEVSFY
NVTDRSQ--LFMFTD-TF-S-ETLRPYFHTGY--------NAAPLTIY-LVP-AQTGETG
ST----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------LKL-
----K---------------------------IKLL-FDYPST-----------LH--IY
FL--WLWL-------------------------------------------HFTAQ-FKV
--------I-GPN-HPIMATAGEDIVLSCHLTPRISAENM-EVRWYRSHF-H---S-LVH
LYRDGDNQNER----QMPEYQGRTEF-LRDDITNGSI-ALRIRSVRPSDEGQYRCF--FR
-S-S--DFHEES-VLE------L--K-VA-----GLGSTP-----------------LI-
------SVEGHQDG-GI-R---M--VCRSAGWYPEPKVLWRDPSG-QLLTS-L-------
------S-------------------KT-TSQGANGLFETQNSIIIT-----E--TSNQ-
NLSC-HIRNTL-LNQ-EKES----T---VYVA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRV--S----------------P----SAV-ALYVI-LVI-----SFVLIGLA--
A-----F-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------LAAALS----------EN-SA-EG-SGRWR---NARRC-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AANVT---M--D-PDTAH
PDLV----------LS-----GDQRSVRLRDT----W--QA-Q------------PDN--
PKRFDYVVSVL-----------GSPSFT---AGRHY---WE-VE-V------EGKTKWTL
GVCKESVR-R--K-GV--------------------------------------------
---------------ITVTPEEGFWVLRLT--Q--------GKKYSALTSR-R-----TP
---------------------------------LSLRVPPR---RVGILLDYEAGAIAFY
NVTDPSR--IFTFT-SSF-S-GPLRPYFCPRASDGG---RNLAPLTIC-PI---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKTM-FFG---CCLRC-----SLLAAVIY----
SSVFRIHE-------------------------------------------LQSVP-FSV
--------Q-GPP-DPVAVAVGQDVVLPCHLSPEQSVQHM-EVMWFRDQF-T---P-FVH
RYRDGQDHYGD----QELRYQGRTEM-LKDGLANGSV-SLRIFRVQLSDRGRYTCL--VR
-S-D--LGYDEA-VVE------L--K-VT-----ASGSAP-----------------LI-
------ALQRYQDG-GI-R---V--ACRSAGWFPQPQLLWRDPHG-QWLPS-L-------
------S-------------------EN-ITQDGGGLYTAESVLILA-----G--GVSQ-
ELAC-VVRAAL-HNQ-EKES----A---FSIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FQNA--R----------------P----WKI-ALSVI-LVA-----VVALSIVA--
V-----YLLKMKGKYEKKIAA--------QAAELGDRD----------------------
-------------------TKIE-------------------------------------
------------------------------------------------------------
---------------------K--------------------------------------
--------QAE-ELVW-IRYAVPIEDAEV-----------------V---L--D-PDTAH
CDLV----------LT-----DDGKSVKRTDR----R--QD-V------------PSR--
PERFDPWRCVL-----------GCKG FT---AG RHC---WE-VE-V--VL---DGGGWTV
GVSQEDVR-R--K-GE--------------------------------------------
---------------IEFGPEEGIWAVG-Q--W--------AGQFQALTSPQR-----TL
---------------------------------LPDVCTPT---RVRVALDYEVGRVAFY
SVDEEIP--IFTFPPVSFQG-IKVHPWLWLGPG--T-------QLKMW-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVCSPDF----------------SLLRDL--FL
ILLFQMSM---KGS----------------------------------------DS-FLV
--------I-GPS-EPIVAMLGADTVLPCRVHPAMNVENM-EIRWFRNQF-S---E-AVF
VYQNGMEQVGE----QLVDFKGRAEL-VKDYITEGRV-AVRIHSLRVSDNGMYKCF--FK
-K-G--TDFEEA-VLE------L--K-VI-----GLGSGP-----------------RV-
------FLVGPEDG-GI-R---L--KCTGKGWFPQPEVQWEDVKG-EKIPS-V-------
------S-------------------ED-EIQDDDGLFQIEASLIVR-----D--SSKT-
QVSC-SMKNPF-FGQ-EQVET-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRP--S----------------P----WKA-AFAVT-LVI-----LGISAGAI--
V-----YLAWKERQGKKKLSK--------V----KEE-KQKESKSK--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------AELYAA-------------AFT---L--D-PKTAH
PNLV----------LS-----ENKQHVSLKNN VS--Q-NGD-A------------STHEE
QRDSEVIFSVL-----------GEKSFTQRDTNR QY---WE-VE-VKTRTEAGSATRCVL
GICSETAK-R--E-GW--------------------------------------------
---------------FVEAPEKNFWVLV-H--E--------EGKVIIPNSQK------NS
---------------------------------PSLRQQPH---RIGVFLDWEAGNLSFY
NMADGSH--IYSFTGITF-C-GTLFPYFSLRGTG-A-------SLTIC-STS-DHPENCP
DSSP----KTSLTHLS--------------------------------------------
-SC-DTSVPQEANS---LLQEVNVST--SAAS--AQASYRY-V-----------------
------------------------------------------------------------
-----------VQESCPS------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDLPGYNLLGM---IASFLLIL
LTMKKSDDFRVIGPAYP-ILARVGEDALLTCQLFPKRTAMHMEVRWYRSEPGTPV-IAHW
DGVEVTQMQVEEYRDRIEWIDD-NIAKGNVTLKIYNIQPSDNGQYWCHFQEGNYHGETSL
LLKVANVGSAPNIHME---------GP---RE---------------------------G
EVQLLCTAKGWF----------PEPQ---VY---WEDITGQRL-----------------
-LTLSEHHIQDEE--------------------------------G------------LF
YVEDTLVMRNMS----------------------------------VETVSCFIYN----
PVLTEVKG------------------------------AVI--ALP--------AS-LKV
--------I-GPS-EPIIVRVGEDIQLTCSLFPKANAQSM-EVRWVQAHH-Y---P-AVY
VYMNGDHVARE----QMVDYRGRTTL-VSDAIHEGRL-TLQIHNATASDDGQYQCL--FE
-K---NGVYQKA-SLD------L--K-VV-----AVGSSP-----------------RI-
------TMEVLTDG-EV-Q---L--MCTASGWFPPPHMQWRDMEG-KTIPSAS-------
--------------------------EI-LHSDSHGLFHVETLLLIT-----N--SSLA-
NVTC-SISNLP-LGE-EKTSA-------FTLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
F---------S---------------------WAILPVLGL-LLAMA-------------
I-----GIICRKN-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEVP------ASLHVM-----RASSLLL-----
-PFLSLLV-------------------------------------------LASAQ-FTV
--------V-GPA-GPILAMVGENITLPCHLSPEKNAEDM-EVRWFRSQF-S---P-AIL
VYKGGRERIEQ----QMEEYQGRTTF-VSRDISQGKV-ALVIHNITAHENGKYCCY--FQ
-E-G--RSYDEA-IMH------V--R-VA-----GLGFKP-----------------LI-
------EMKGHKDG-GL-W---L--ECTSAGWYPEPHAVWRDPYG-EITPSLE-------
--------------------------EA-CTVDRDGLFTVTMVVIIR-----D--SSVR-
NMTC-SISNIL-LGQ-ELETV-------IFIP-ESFTP-------SLSPWTVVLAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------S-LAILIPF-----MSG--T
I-----CLIKKLHRGKKN-ESE--------EKDSEYEERE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----NAQQLQEELRW--------------------RRSLVHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSR----QS-L------------PDN--
PERFDCRPCVL-----------GQES FS---SG RHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPMKEHLC---RVAVFLDYEAGDVSFY
NMRDRSH--IYTCPLSTF-S-GPLRPFFRLGSDDSP-------L-FIC-PVF-TGAQGVV
IPE--------GGLILHRPRPVLWSQSHVRKP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MV---------DFPGY-----NLSGA-VA--SF
L-FILLTM-------------------------------------------KQSED-FRV
--------I-GPA-HPILARVGEDALLTCQLLPKRTTMHM-EVRWYRSEP-S---T-PVF
VHRDGVEVTEM----QMEEYRGQVEW-IENGIAKGNV-ALKIHNIQPSDNGQYWCH--FQ
-D-G--NYCGET-SLL------L--K-VA-----DLGSAP-----------------NI-
------HMEGPGES-GV-Q---L--VRTTRGWFPEPQVYWEDIQG-EKLLA-V-------
------S-------------------EH-HIQDEDGLFYVEATLVVR-----N--ASAE-
SVSC-LVHNPV-LTE-EKGSV-------ISLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------K
L---QTEL--G----------------K----YEV-VAHTC----------GGSLCP---
-------PQQREGSY---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------HETM--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MALFKPADVF---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GRENFT---SGRHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTTGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-N--P--D-----------------------LVPD--------HSLETPVA------PDL
ANESGERQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVY
LLLVQ-------------------------------------------LLTPFCCA-WTP
-----------------WAHPGEDSDLHCHLFLTVSAETM-ELRWISSSL-R---R-VMN
MYVDCKEVEDR----QSAEYRGRTSI-LQDGITAGNA-ALRIYNVTASDNGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDI-----------------HI-
------EVKGYEDG-GI-H---L--GCRSTGRYPQPPIQWSNTKG-ENIPAV--------
--------------------------EAPMVADGV-----AASVIMR-----G--SSGE-
GVSC-IIRNFL-LGL-EKTAS-------ISIE----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--K----------------P----WIT-ALAGT-LPI-----SLLLLTGA--
S-----YFLQQERKEKTAL---------SRETEREREMKEMGYATKM-------------
----------------YLIL---------YPDM---------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------ANARHLLKLSAVYVI---L--Y-PDMAN
AIVL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PERFEWRYCVL---------------------G S HY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKVW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------ENKYQAL------------
---------------------------------------TE---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTS-KEAESSP
D---P--DL----------------------V-PD--------HSLETSVT------PGL
ANESGERQADVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-C---L--ECTSVGWYPEPQVQWRSSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQN LL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----IPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWR---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSV-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGSEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPV-------SLTSS------LVFLMHLLL--
---LQHGE------------------------------------------PS-SE--VKV
--------L-GPD-HLILAIVGEEVEFPCHLWPQLDAQQM-EIRWFRSHT-S---D-VVH
LYREQRELPGR----QMQAFRNRTKL-VKDDIAYGSV-VLQLHSIVPSDKGMYGCR--FL
-S-D--NFSGEA-LWE------L--E-VA-----RLGSDP-----------------HL-
------SLEGFQEG-GI-Q---L--RLRSSGWYPKPKAQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----A--GALS-
NVSL-SIQNLL-LGQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------P----WKG-AFFGT-LAA-LPPLLLVLAALA--
L-----GLLQKQRRRRGTGAG--------PP-E-RQG---SLGSDVLI--S---------
-----------------CFPLVAS----DWRRAEGQ-----------------A----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLE----------VS-----ADGKSVCSR---GAPP--GP-A------------PGH--
PQRFSEQTCVL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GS--------------------------------------------
---------------VRLSPATGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALPLRVPPR---RLGVFLDHEAGQLSFF
NVSDGSH--IFSFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTI-------LGTSVP
EGN------DSDAWLQ----------------------------PY-EP-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FMV
--------I-GPS-EPIVAVLGDDAILPCSLFPAISAEHM-ELRWSRSHF-L---E-TVF
IYRNHQEQKEE----QMPEYTGRTLL-VRDFLTQGQA-ALRIHNVQVSDNGMYSCF--FK
-E-G--SYYEGA-NLE------L--K-VA-----GLGSAP-----------------QV-
------HIEGPEQD-GV-R---V--LCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGS-LTV-----LGLLLFGA--
G-----CFTRREHSAKLQESQ--------KQEKLGWD-KEEDQRAEEET-LKAR------
------------DE-LQ----AELG-----RRKAAY--L--AAWR---KAQLYA------
------------------------------------------------------------
------------------------------------------------------------
--------------AV-NV-------------------------------L--N-PGTEP
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MSMAP
---S---------------------------------SCPP---------GCL-----LL
LMVLQLPK------------------------------------------MDSAAR-FDV
--------I-GPQ-EPVVALVGADAELPCRLSPNVSAERM-ELRWFRRTR-S---P-AVL
LYRDGREREAE----QAAEYRGRATL-VTHGLRAGRA-ALRIRGVRASDDGEYRCF--FR
-D-GD--SYEEA-VVH------L--K-AA-----ALGSDP-----------------HI-
------SMGVQESG-QV-Q---L--ECTSSGWYPEPRVQWRTPKG-EDFPS-T-------
------S-------------------ES-SNPNEEGLFTVAASLVFR-----D--NSVE-
NMSC-SIQNI L-LGQ-EKEVE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPRLM-T----------------P----WMV-AVAIF-LVV-----FGLLTIGS--
V-----FLTWRLYKERSRMRK--------SEFGSK-------------------------
-------------------------------EKLLE-EL---NCK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-QDTAH
PHLF----------VY-----EDSKSVRLEDS----R--QT-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAV
GVCRESVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GDGYWALTTL-R-----TP
---------------------------------LSLLGTPR---RVGIFLDYDAGDISFY
NMADGFP--IYTFPRLSF-S-GPLRPFFCLWSYD-------KKPLTIC-PIG-NRSERVT
VGAD----I------------------------QD--------LSQGIPLS---PLGEVP
ASGDPDT---LHSK---LIPTSSSQR--TP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FSV
--------I-GPA-EPILALEGGDAEMLCHLSTKESAEDM-EVRWFQSHP-S---N-IVH
LYEYGEEKFGR----QMEEYQGRTKL-VRDAIDYGSV-AVRIRNVRVSDEGQYRCS--FF
-N-G--VYDEEA-TLE------L--Q-VV-----GLGQEPVLS----HSCPTDHSSPHL-
------RFQGGESD-HL-LNM-----------------KWQDIAG-QRQDM-G-------
-EREVHEHPT-PC---------HTQP----------------STHTY-----T--RSMG-
ILCC-NNNNPI-EGA-QDPQ----S---FLLP-S--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPTA--L----------------S----LIV-ALGVI-LPV-----LGLLIAGG--
L-----YLIWKHPRDKAGKGS--------R-PDREGR--------DRQMRTHPTENEHS-
SQS----------G-MQKNLK---------NKLALY--K--LCWG---KSQRMP----NF
R-------------------SQKSAER---------------------------------
------------------------------------------------------------
--------------------------------------------SFK---VVPI-PDHME
SVYQ----------LN-----EGVKK----------------------------------
---QCGHVCPLEQGGVGRVIPGNQSGNS---SGTKC---WE-VE-V------GEKRSWYL
GVCRENVK-R--K-WW--------------------------------------------
---------------ISASPENGFWTVE-K--I--------EDRSWARTAS-R-----PR
---------------------------------LPLIPRPR---RVVVYLDCEAGDVSFY
SGTDGCH--IYTFPRAAF-S-GTLRPFFYLWSSDPV-------PLT--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESA------AALHFS-----RQASLLLL--LL
LLLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPA-NPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEGYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GVVPALK-------
--------------------------EV-SMPDADGLFMVTTAVIIR-----D--KSVR-
NMSC-SINNTL-PGQ-KKESV-------IFIP-ESFMP-------SVSPCAVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILMIP-----IAI--C
I-----YWINKLQKEKKI-LSG--------EKEFERETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEE----EL----------------------------------------
-QV---KEKLQEELRW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--CPFR-HLGES-V------------PDN--
PERFDSQPCVL-----------GREN FT---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KGQYRAVSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFLRLGCEDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASL-L-----
-LLLSLCA-------------------------------------------LVSAQ-LTV
--------M-GPT-DPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSSDEA-ILR------L--M-VA-----G-------------------------
------------------------------ALLPFPFTVWRDPSS-EVVPALK-------
--------------------------ED-FTSDTDSLFMVTTAVIIR-----D--RSVR-
NMSC-SVNNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPYVVALPV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-VLILMIP-----IAV--C
M-----YWINRLQKEKKI-LLG--------EKEFEREMREIAIKDLE-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KEKEL--------------------------------------------
--------QIKGKRGW--------------------RRMFLHAADVF---L--D-PDTAH
PELF----------LS-----EDPRSVRR--DPSR----ES-V------------QDN--
PERFDSQPC V---------------------------------E-V------E NVMVWMV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLEMC-----------ESEYWALTTPKW------I
---------------------------------LSMEESLC---RVGVFLDYEAGDVSFY
NMGNRSH--IYTCLRSVF-S-VPVRPFFRLGSYDSP-------I-LIC-PTL-SRADGVT
VPE--------EGLTLHRAGTHRSPQDQFPGLTAM-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDTA------AAPHFS-----LPGSLLL-----
-LLLSLCA-------------------------------------------LVSAQ-LTV
--------V-RPA-SPILAMVGENTTLHCHL-------------WFRSQF-S---A-AVF
VYKGGRERTEE----QMEEYRGRITF-VNKGISRGSV-ALVVHNVTAQENDIYRCH--FQ
-E-G--WSYDKA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--QCISGGWYPEPLTAWRDLYS-EIVPTLK-------
--------------------------EV-SIADADGFFVVTTAVIIR-----D--KSVR-
NVFC-SIENTL-LSQ-EKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--T----------------P----WMV-SLAVI-LAVFLIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------R-TFLHAA--P---K--N-PNTTH
PELF----------LS-----EDQRSVRQ-------------V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTV
GVCGDGVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEVF-----------GNQYWALSSPDR------I
---------------------------------LPLKESLC---WVPIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSGDSP-------I-FIC-PVL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKGSPSSP-----LT--------GRLLPL----
--LLLLSS---GVS-------------------------------------GAVSW-FSV
--------K-GPA-EPITVLLGTDATLPCQLSPEQSAARM-HIRWYRAQP-T---P-AVL
VFHDGQEQGEA----QMPEYRGRTQM-VRQAIDTGSV-ALQIQQVQASDDGLYHCQ--FT
-D-G--FTSQEV-SME------L--R-VI-----GLGSAP-----------------LV-
------HMTGPENN-GI-R---V--QCSSRGWFPKPKVQWRDTLG-NTLLS-S-------
------S-------------------EL-QTQDRDGLFQVEASLLVT-----D--RAVG-
NVIC-SIQNP--YDQ-EKSKA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKM--C----------------P----WKV-ALVCS-VPI-----LLALLSGI--
S-----LGVWKEHQVKRREIK--------KWSKEHNE-MLLMKKGTKSV-LKIR------
------------DD-----LQADLD-----RRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQE-------------APVR---I--N-HEMPD
QDKT----------DS-----KTK------ENRR--EE-----------------SVSSS
--QVDQNIITL-----------YQEGFM---LGRYY---WE-VD-VEDTE------EWTL
GVYELCTQ-D--A-S---------------------------------------------
----------------PTDPLRKFRVLE-K--N--------GDGYRALGFCSQNISLEEP
---------------------------------LSLETRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFPQDAF-S-GSLSPYFTRNSTG-L-------SATAQ-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------YHST------ISFLILS--HH
IYLCGYSI-------------------------------------------LSNRL-FDV
--------I-GPA-EALIALVGEEAVFLCHLNPSMNAEDM-EVTWHRNDL-E---G-VVY
YYGKTQNNVKH----QRQEYQGRTEF-LKENITKGQM-ALRIHPILPSDEGEYSCS--FI
-S-S--VHSSSA-EFL------V--S-VT-----GEPLI-------------------N-
------NCKGNHST-SI-Q---L--TCTPTGWYPEPEVQWRELQG-RRLAP-D-------
------T-------------------ET-MTTNDIGLVLVKSSITVY-----GIMESGG-
IMSC-FIRNPV-QNV-EKGA----H---ISIA-R--------------------------
------------------------------------------------------------
-----------------------------------------------------------E
F-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------ASLHFS-----LPASLL-L----
-LLLRLLA-------------------------------------------PVSAQ-FTV
--------Q-GPA-DPILAMVGENTTLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVL
VYKGGRERTEE----QMEEYRGRTTL-VSKDISRGKV-ALVIHNVTAQENGIYRCY--FQ
-E-G--RSYDEA-MIH------L--K-VA-----GLGSEP-----------------LV-
------EMQGHEDG-GI-R---L--ECTSGGWYPEPLAVWRDPYG-KVVPALE-------
--------------------------EA-YTADADGLFMVTTAVIIR-----D--SSVR-
NMFC-SVNSTV-LGQ-EKETV-------IFIP-EYFTP-------STYPLVVILAP----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LAILIIL-----MAV--S
I-----CCSKKLHREKKI-LSE--------EKDVEQEEKEIA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPSR----QS-V------------PDN--
PKRFNCQPCVL-----------GREY FT---SG KHY---WE-VE-V------ENLMAWTL
GVCKDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------ENKYRALSSPER------I
---------------------------------LPLRERLG---RVGIFLDYEAGDVSFY
NMRDRSH--IYTCPRSPF-T-GPLRPFFRLGSDDSP-------L-FIC-PAL-TGANGIT
VPE--------EGLILHRARTLQRPR----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SGL----------AFLLLNSLAC
LILVQ-------------------------------------------LLTPCSAQ-FAV
--------H-GPP-GPILAMVGEDADLPCHLSPTMSAETM-ELRWVRSSL-R---Q-VVA
VYAGGKEVEDK----QTPEYRGRTSV-LRDHITAGKA-ALRIHNVRLKVAG---------
-------------------------E-PP-----ALGADL-----------------YL-
------EMKGHEDG-GI-H---L--ECRSTGWYPQPHVQWRDAKG-EVIPAV--------
--------------------------AAPVVADGVGLYAVAASVIMR-----G--SSRE-
GVSC-TIRNSL-LQQ-EKTAR-------ISVA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGS-LPI-----LLLLLAVA--
G-----YFLWRQQEEKKTL---------LREKEREQEMRELAQSATK-------------
----------------QERS---------TR-----------EWR---KIQYMA------
----------------------REQ-----------------------------------
------------------------------------------------------------
-------------------------------------MLYLSAANVI---L--D-PDSAN
PILL----------LS-----EDLRGLQRAEE----E--QD-R------------PDI--
PERFNWRYCVL-----------GRES FT---SG RHY---WE-VE-V------GDRQEWHI
GVCRRNVE-R---KGW--------------------------------------------
---------------VKMIPENGYWTMGQS--G--------ENNYRALTEP-R-----TK
---------------------------------LTLAGPPK---RVGVFLDYETGEVSFY
NAMDGSH--IYTFPHTSF-S-GPLCPVFRILTLEPT-------ALTIC-PAP-KETERLG
MPDSV--PD----------------------LVPD--------LPLETPVT------PGL
ANETREPEGEVTCP---LLPAQSGA-ESLPIH--------S-NHHNHEATCTA-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ACSA-----G-----SWLSGCLI-----P
LVFLRLPA-------------------------------------------HV-SG-L--
--------A-GDASKFHVAPLGGTAELLCPLSLWPGMVPE-EVRWLRSPYPQ-RSQ-AVH
VFRDGKDRDED----LMPEYMGRTAL-VRDA-QEGSV-TLQILDVRLEDRGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
V---S-----P---------------------SA-VALAVI-LPV-----LVLLILVC--
L-----CLIWKQRKAKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--LS-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---SGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYDAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEERI
VPKP---------------------------------------------------EGKG-
-YANGDMSLKVNSS---LLPHKAPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHLS-----RPASLLLL----
LLLLSLCA-------------------------------------------LVSAQ-VTV
--------V-GPT-DPILAMVGENTTLRCCLSPEENAEDM-EVRWFQSQF-S---P-AVF
VYKGGRERKEE----QKEEYRGRTTF-VSKD-SRGSV-ALIIHNVTAEDNGIYQCY--FQ
-E-G--RSCNEA-ILH------L--V-VA-----GLDSEP-----------------VI-
------EMRDHEDG-GI-Q---L--ECISGGWYPKPLTVWRDPYG-EVVPALK-------
--------------------------EV-STPDADSLFMVTTAVIIR-----D--KSVR-
NVSC-SINDTL-LGQ-KKESV-------IFIP-ESFMP-------SRSPCVVILPV----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------MIILMIP-----IAI--C
I-----YWINNLQKEKKI-LSG--------QKELEQERKETALKELE-------------
------------------------------------------------KEHVE-------
------------------------------------------------------------
-----------KEK----------------------------------------------
------ELQIKGKRGW--------------------RRTFLHAANVV---L--D-QDTGH
PYLF----------VS-----EDKRSVTL--DPSR----ES-I------------PGN--
SERFDSQLCVL-----------GQES FA---SG KHY---LE-VD-V------ENVIEWTV
GICRDNVE-R--K-WE--------------------------------------------
---------------VPLLPQNGFWTLEMH-----------KRKYWAPTSPKW------I
---------------------------------LSLEEPLC---QVGIFLDYEAGDVSFY
NMKDRSH--IYTFPHSAF-S-VPVRPFFSLGSYDSQ-------I-LIC-SAF-TGASGVT
VPE--------EGWTLHRAGTHRSPQNQFPSLTAMETSPGHLSSHCTMPLVEDTPSSPLV
TQ-ENIFQLPLSHP---LQ---I----SAPVHLLIRCGFSSSFGCNYGMESRH-------
-------------RELVV----PQL-----------------------------------
----------------------------------PARKKV--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSLQPC-----LLASLLF-----
FLVLSLFV-------------------------------------------LVSAQ-FTV
--------V-GPA-EPILAMVGENTTLRCCLSPERNAEDM-EVRWFRWHF-S---P-AVL
VYKGHQERTEE----QMATYQGRTTF-VSTDISKGRV-ALVIHNVTAYDNGIYSCY--FQ
-Q-G--RSYDQA-IMR------L--L-VA-----SLGSKP-----------------LV-
------NMKTLEDG-SI-L---L--ECTSEGWYPEPQAVWRDPYY-EVVPALE-------
--------------------------ED-YTADRGGLFTVTMTVIIR-----D--CSVR-
NMTC-SVNNTL-LNQ-EMESV-------IFIP-ESFEP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AMAVT-LPVLMLILL---TSG--S
I-----FLVKKQHRKKLI-LS---------------AEKEVEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----EATRQLQEELRW--------------------RRTLLHAADVL---L--D-PDTAH
PELF----------LS-----DDQRSVRR--GASR----QS-V------------PDN--
PERFDCRPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWTL
GVCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GNQYRALSSPET------I
---------------------------------IPLKERLH---RVAIFLDCEAGDVSFY
NMRDRSH--IYTCPPVAF-A-GPLRPFFRLGSDDSA-------L-FIC-PAF-TGAQGVT
IPE--------GGLILYRTRSVSQSHGKKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FLGFLKQI-------PRCLS------IFF-T-YLL--
--FLQLWE------------------------------------------VN-SDK-VWV
--------L-GPE-ESILARVGEAVEFPCRLSSYQDAEHM-EILWFRTQV-S---N-VVY
LYQEPQGRSSP----QMAQFRNRTLF-EAYDIAEGSV-NLHILSVLPSDEGRYGCR--FL
-S-H--NFSGEA-MWE------L--E-VA-----GSGSDP-----------------HI-
------SLQGFNGE-GI-Q---L--QCSSSGWYPKPKVQWRGHQG-QCLSP-E-------
------S-------------------ED-ITQNAQGLFSLETSVIVR-----G--GAHS-
NVSC-IIQNPL-LPQ-KKEFV-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRM--S----------------P----WKK-AFVGT-LVV-LPLSLIVLTMLA--
L-----RYFYKQRSFQEKRVK--------QEEE-VRE-----------------------
------------------KLQTEL----DWRRSEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----NNGKSVSSR---LGVP--SI-A------------AGD--
PQRFSEQTCVL-----------SRER FS---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--S-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------RCEYFVLDPH-R------V
--------------------------------ALALRVPPR---RIGVLLDYEAGKLSFF
NVSDGSH--IFSFTDTF--S-GALRAYLRPRAHDGS---EHPDPMTIC-SLP-VRGPQVL
EES------DNDNWLQ----------------------------PY-EPL----------
-----DPAWAVNEA---VS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKPE--FF---CFS--------GFC------VY
FLFLQ--V------------------------------------------VVSSEK-LRV
--------T-TPT-RHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGH-S---Q-PVY
LYRGGHKMSEE----AAPEYANRTEF-VKEAIGEGKV-SLRIHNINILDDGPYQCS--FN
-G-S--GFIDAA-IMN------L--N-VT-----AVGLET-----------------EI-
------HVQAPDAD-GV-M---V--ECNSGGWFPRPQMEWRDSKG-ATLPH-S-------
------L-------------------KS-YSQDEARFFYMKMTLLLT-----N--MSHG-
SIIC-CIFNPV-TGE-EKQTS-------IILA-NELFN-------RDRIWMESLASI-VW
I-MLSVYILYIICFYWRTGCAS-----------------------------------GCL
SKCFCVVTSWPVQIVH--LL---FCTGTFFAIYLPHR---------------SRVSLSDP
Q---FPLY--N--------------------NWI-TELLF-VILF-LTI-CFALPIIL--
------LFIQFQFTSLTK--W--------EKNKDGIM--------DQ-PRL---------
------------------------------G-----------------KAHE--------
-----------TSSLYR-----KKTG----------------------------------
-KSWEQEK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MNVLSFC
---SS---------------------------SAVS-SSLP-G-----------LI--IF
FITYHIQK-------------------------------------------LESAE-FTV
--------M-CPA-HPVMATVGEAIELPCHLSPRMSAENM-EVRWFWSDF-L---S-FVH
LYQDGKDEHEQ----QMTEYRGRTEL-LKAGLTEGNV-SLRILNVKPMDRGQYRCL--VR
-D-G--IFYKEA-LLE------L--K-VA-----VLGSSP-----------------LI-
------SVQGHQNG-GI-R---V--VCQSAGWYPKPEMLWRDHIG-HLLTS-L-------
------S-------------------EA-ISQVDNDLFRTESSIIMR-----E--HANQ-
SLSC-CIRNTL-LNQ-EKES----T---IHIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRV--S----------------P----WMV-ALIFI-LLV-----LFGFMGLT--
V-----YLFKIK----GKSHV--------G-E---CM-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------K----------------------------LIRDC--PLA---S--K------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------NFL----------AFLLLNFHVC
VLLLQ-------------------------------------------LLMPHSAQ-FAV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDDITAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-KNIPAV--------
--------------------------EAPVFADGVGLYAVAAAVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQY--------
--------------------------T---------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LKLPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDISF-S-EPLYPVFRILTLEST-------ALTIC-PAP-KEEESSS
NS--D-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAIVGENTTLHCHLSSEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGRRERTEE----QMEEYRGRITF-VSKDISRGSV-ALVIHNVTTQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKVQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPALK-------
--------------------------EV-SIADADGLFMVTTAVIIR-----D--KSVR-
NVSC-SVNNTL-LSQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVGVFLHYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGTQESL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MERA------ASLHFS-----LPGSLLF-----
FHLLSLFA-------------------------------------------AVSVQ-FTV
--------L-GPA-DPIQAMVGEDTKLHCHLSPEKNAEGM-EVRWFRTQF-S---P-AVF
VYKGHRERTEE----QMEEYRGRTTF-VSEAISKGSV-GLIIHNVTAHDNGIYRCY--FQ
-E-G--RSYDEA-IMY------L--I-VA-----GLGSKP-----------------VI-
------EMKGHEDG-GL-R---L--ECTSVGWYPEPHAVWRDPYG-EIMPPLE-------
--------------------------EA-YTTNEDGLFMVTTAVIIM-----D--ESVR-
NMTC-SVNNTL-LNQ-EKETV-------IFIP-ESFIP-------STSPWLVALTV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LPSLLLI-----IAG--S
I-----CIVKKLQMEKKL-LSM--------QIEIENEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLHEELRW--------------------RRSLLHAXXXX---X--X-XXXXX
XXXX----------XX-----XXXXXXXX--XXXX----XX-XXXXXXXXXXXXXXXX--
XXXXXXXXXX-----------------X---XXXXX---XX-XX-X------XXXXXXXX
XXXXXXXX----------------------------------------------------
----------------XXXXXXXXXXXXXX-----------XXXXXXXXXXXX-------
---------------------------------LPLRERLR---RVGIFLDYEAGDVSFY
NMRDRSH--IYTCPRSPF-S-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
VPA--------GGLVLHRAETHRSLQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SCLP---------RCL-----FI
LTLLQLPK------------------------------------------LSA-AH-FDV
--------I-GPS-EPILAMVGEDAELPCHLSPNMNAERM-ELRWFRRKV-S---P-AVL
VHREGREQKEE----QMPEYGGRVTL-AKDDISVGRA-AVRIQGVRASDDGEYQCL--FR
-E-NG--SYGIA-LLH------L--T-VA-----ALGSDP-----------------HI-
------HMEVQESG-EI-S---L--ECTSVGWYPEPQVQWRTPKG-EQFPS-T-------
------S-------------------ES-RNPDEEGLFTVASSVIIR-----D--TSME-
KLSC-YIQNLL-LGQ-EKEVE-------ISIP-DTSV-----------------------
------------------------------------------------------------
------------------------------------------------------------
LTTCLRS-I-T----------------P----WRV-AVAVI-LTA-----LGLVTIGF--
I-----FFTWRLYKERSRERK--------NALSPK-------------------------
-------------------------------DKVLE-EL---KWK---RSPWH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AADMI---L--D-PDTAH
PHLF----------LY-----EDLRSVRLEDS----R--RI-L------------PER--
PERFDSWPCVL-----------GCKA FT---SG RHH---WE-VE-V------GDRTDWAI
GVCRENVR-R--K-GF--------------------------------------------
---------------DPIIPENGFWALELY-----------GNGYWALTPL-R-----TP
---------------------------------LLLSSPLH---RVGIFLDYELGNISFY
NMTNGHH--IYTFSENRF-S-GPLRPLFCLWSSG-------EKPLIIC-PLA-DGPESVT
VIAN----A------------------------QD--------LSKEIPLS---PMGEDS
ASEVTDT---FHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MQM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------A-GDASKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----VMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCM--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIIAC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-E-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----DDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---S---------------------------------SGLP---------RCL-----LT
LILFQLPK------------------------------------------LDS-AP-FDV
--------I-GPL-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-C---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERPRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSD--IYTFSNVTF-S-GPLRPFFCLWSSG-------KKPLTIC-PIA-DGPERVT
VIAN----A------------------------QD--------LSKEIPLS---PMEEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MANT-HGRV-IFPPSC-S---II---IIV--LQ
LLSCSTPA-------------------------------------------NGKAD-FSI
--------I-GPK-IPVLAVLGENVELPCRLSLNISAEDM-ELRWYRNQP-S---Q-VVH
LHKNGTDMKEE----QMREYQGRTTF-LSAGLDQGKA-TVKIHNVTVFDNGTFHCN--FK
-D-G--NMSAET-RLW------L--M-VA-----GLGGMP-----------------RI-
------QVQAVQGE-IV-W---A--QCTSEGWFPEPQAEWRNFRG-QPLPS-M-------
------T-------------------HL-SASPTTGLFTVVSNVTIQ-----D--GDVQ-
NFSC-CISSPL-LQK-KMVN----Y---HLL------P----------------------
------------------------------------------------------------
-----------------------------------------------------------Q
L---SRSS--L----------------S--KEWKI-VLPLI-FTL-----AGLVTAGA--
T-----CLYQKCQKDRNVGQL--------EEERLH-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------RAEEQHSQDW-T-------------------EDKVIYVSPS---L--D-PDTAS
PKLA----------LS-----EDGKSVRRLFF----D--QE-L------------PDV--
PSRFDQDPCVL-----------AREQFS---AGRYY---WE-VQ-V------GQRKAWNV
GVCLESLN-R--K-GR--------------------------------------------
---------------IPKAPQHGLWALE-L--Y--------KKTFWALAFP-R-----VR
---------------------------------LHPSGPLH---QSP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVPSC
---PISWASIPA----------WCSPAVLELMGFPD-SSLPSY------LI---SL--LL
LLLFQLLP-------------------------------------------QTSAQ-FTV
--------I-GPA-QPIVVQVGEVAELPCHLTPKMNAGNM-EVRWLRATF-S---P-AVF
VYRDGRGQFEE----QMEEYRERTEL-LNDFITDGRM-TVLLHDVRVSDNGSYHCR--FQ
-N-S--QHVAKS-TLD------L--V-VA-----AEGSDP-----------------NI-
------RLEGQEDG-GI-L---L--ECTSTGWHPEPQVQWKDSKG-RNVTL-R-------
------S-------------------IY-QPQGADGLFHVVTSVIIR-----D--DSVR-
TVSC-SIWNPY-RGG-KKEA----T---IPIE-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FRTV--S----------------P----STV-ALAVI-LPV-----LVLLMAGA--
V-----CLLWKRHRKKKKKKK--------K-REN-TW-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------NEL--LSS-N-------------------YCKLCVF----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------LEDCCRCS-----LLH---HLT-CLL-------
-VLAQLPT---WVS---------------------------------------TQK-FRV
--------V-GPS-EPIVVVLGEEATLPCSLSPALSVEDM-ELRWFRTKF-T---E-AVF
VYRNGREQKEE----QLAAYAGRTSL-VMDFFTQGQA-AVRIRNVQMSDSGIYICF--FK
-K-G--VFNEEA-ILE------L--K-VT-----GLGSVP-----------------EV-
------HIQGPEDG-GV-L---L--VCTALGWFPKPQVQWIDPSG-ETLQA-F-------
------F-------------------ET-YTQDTQELFSVETRLMVR-----D--SSVG-
NVTC-SILNPI-LGQ-DKAMA-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FSQA--F----------------P----WKL-TFAVI-LTM-----MGLLLFGA--
G-----CFIQREYSIKLKVKK--------ERKSLQRE-GQPSSEKG--------------
--------------------CSDCV-----LIRVCF--L--SAWK---KAQIYA----G-
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------PVT---L--D-PDSAH
PSLA----------VS-----QDRMTVTCKDT SM--L-----------------------
---SNDTFSVL-----------GLEGIL---SG RCY---WE-VE-VKNT--DS---KWTL
GVCRKDEQ-Q--K-DW--------------------------------------------
---------------NLKLPRNGFWIFG-L--S--------GTGYWAYTEP-W-----TS
---------------------------------LSLKQDPC---RVGVFVDYSEGDVSFY
NMSNRSH--IFSFQKASF-S-GTLLPYFSFTSGD-V-------SLTIC-SMV-SGPEGLS
VPLR-----------------------------PS--------PSVEEILS-APGEELNS
GSAVDDSLPGAEFP---LLPCSPETV--PP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ATGADP-----------------HL-
------SLGGYEAG-GV-R---V--LCQSAGWYPLPQLLWRDTRG-QHLPS-V-------
------S-------------------QT-HSQDQEGFFEIEGAVIVT-----R--SVEG-
PLSC-MGTPLG-LEQ-GALGGRPGS---MAAA-W--------------------------
------------------------------------------------------------
-----------------------------------------------------------G
W---WQGA--A----------------P----LHM-FPPSNQAAL-----LTT-------
-----------------------------SSSAFAFQ-----WHRAERAR----D-----
-----TAGM-DERNGDQVMGCVLG---LPWAKQLSH--H--A-------LISYP------
SY----------------------------------------------------------
--------------ITFLSFSE--------------------------------------
--------KRSAELAW-RK-----------------F--LLPHMKVT---L--D-PDTAH
PHLV----------VS-----QNNSSVRLESE----R--QQ-V------------PDT--
PERFDNWGCVL-----------GHEEFR---EGRHC---WL-VE---VEGEQLKYSWWAV
GVARASVE-R--K-VE--------------------------------------------
---------------INMSPEDGIWAVL-Y--Y--------EGQLRSLKSP-L-----TP
---------------------------------LSLSPVPT---RIWVCLDCTQQQVSFI
NADNGVQ--IFTFTAASFNG-ESIHPWFQLFTEGFQLSLRDSTPQTLS-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKGSPSVP-----PA--------GCLLPL----
--LLLLFT---RVS-------------------------------------GEVSW-FSV
--------K-GPA-EPITVLLGTEATLPCQLSPEQSAARM-HIRWYRAQP-T---P-AVL
VFHNGQEQGEV----QMPEYRGRTQM-VRQAIDTGSV-ALQIQQVQASDDGLYHCQ--FT
-D-G--FTSQEV-SME------L--R-VI-----GLGSAP-----------------LV-
------HMTGPEND-GI-R---V--LCSSSGWFPKPKVQWRDTFG-NTLLS-S-------
------S-------------------EL-QTQDREGLFQVEVSLLVT-----D--RAIG-
NVIC-SIQNPI-YDQ-EKSKA-------ILLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKT--C----------------P----WKV-ALVCS-VLI-----LLVLLGGI--
S-----LGIWKEHQVKRREIK--------KWSKEHDE-MLLLKKGTKSV-LKIR------
------------DD-----LQADLD-----RRKALY--KE--DWK---KALLYP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-RK------ELFQE-------------APVR---I--N-YEMPD
QDKT----------DS-----RTE------ENRG--EE-----------------TVSSS
--QVDNNLITL-----------SQEGFM---LGRYY---WE-VD-IKDTE------EWTL
GVYELCTQ-D--A-S---------------------------------------------
----------------LTDPLRKFRVLE-K--N--------GDGYRALEFCSQNINSEEP
---------------------------------LQLKTRPL---KIAIFLDQEDNDLSFY
NMTDETH--IFSFAQVTF-L-GSPYPYFIRNSTG-L-------SATAQ-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MVT---------------------PRLSSLL---
------------------------------------------------------------
------------------------------------------------------------
LALLQLQV------------------------------------------LCAAAR-FDV
--------I-GPA-EPVLAAVGSDAELPCSLSPNVSAEHM-ELRWVREAP-L---P-AAL
LHRYPQGRAQE----SAPEFRGRVKL-VADGIATGRA-AAQIHRVRAADEGDYRCL--FR
-D-DA--SSGEA-TVR------L--R-VA-----ALGSDP-----------------HI-
------SMEVQESG-EI-W---L--QCTSVGWYPEPHVQWRTPTG-EKFLS-T-------
------S-------------------ES-RSPDQDGLFTVAASVIIR-----D--TSLE-
NVSC-CIRNLL-LDQ-QKEEG-------ISLS-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-S----------------P----WQV-AVAVV-LTV-----LGLLTIGS--
I-----VFIWRLYKDRFRERK--------SEFSSK-------------------------
-------------------------------EKLLE-EL---KLK---KASLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VDVT---L--D-PDTAH
PHLF----------LY-----GDSKSVRLEDS----R--QK-L------------PEK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAV
GVCKEDVM-K--K-GF--------------------------------------------
---------------DPLTTENGFWAVELY-----------GNGYWALTPV-R-----TP
---------------------------------LPLAGSPH---RVGIFLDYDSGDISFY
NMTSGSH--IYTFPSISF-S-GPLRPFFCLWSCG-------KKPLTIC-SVV-NGPEEVK
VIGD----T------------------------QG--------LSKDIPLS---PMGKES
ASEDADT---LHSK---LIPLQASQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-VPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKGISRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSYDEA-ILR------L--A-VA-----GFGSKP-----------------LI-
------EIKIQEDG-SI-L---L--ECISRGWYPEPLTVWRDPSG-EVMPALK-------
--------------------------ED-STRDADGLFIVTTAVIIR-----D--RSVR-
NMSC-SVNNTL-LGQ-KKESV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILAT--S----------------P----WTV-ALAVI-LAIFIIF-----MAV--T
I-----SCIKKLQREKKILLSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------EELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPFR----QS-V------------QDN--
PERFDSQPCVL-----------GRER FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------FLLLPENGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKEPLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSVF-S-RPMRPFFRLGSDDSP-------I-FIC-PAL-TGADGVT
VPK--------EGLTLHRAGTHHSPQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LLFLRLSV-------------------------------------------HV-SG-R--
--------T-GDTSKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-VVH
MFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LILLIMVC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSEHAKEK-GK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PETAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GHKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------HGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKGPEL-----K---DIILSLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPNALLFF----
-HLLSLFA-------------------------------------------LVSDQ-FTV
--------V-GPA-DPILAMVGGNSMLHCHLSPEKSAEDM-EVRWFRSQF-S---P-AVL
VYKGGRERTEE----QMKEYRGRTTF-VKEEISKGSV-ALIIHNVTAHENGIYHCY--FQ
-E-G--KSYNEA-TMR------L--M-VA-----GLGSIP-----------------II-
------EMEIHEDG-GI-W---L--ECTSVGWYPEPQVVWRDPHG-KIMPALE-------
--------------------------ET-YTMDADSLFMVTTAVSIR-----D--RSVR-
NVSC-SINNTL-LGQ-EKETV-------IFIP-ESFIP-------TTSPWMVVLVV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------I-LPTLLLL-----ISG--S
I-----CLINKFHR-KKI-LSG--------EKEVENEEKEIA------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------QQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPFR----QS-V------------PDN--
PERFDCRPCVL-----------GLENFS---SGRHY---WE-VK-V------ENVMVWAV
GVCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTFEMF-----------GNQYRALSSPEK------I
---------------------------------LPVKERLR---QVGIFLDYEAGDVSFY
NMRDRSH--IYTCPRSTF-F-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVM
VPE--------GGLILHR------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMG------NFL----------AFLLLNFHVC
VLLLQ-------------------------------------------LLMPHSAQ-FAV
--------V-GPP-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDDITAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-KNIPAV--------
--------------------------EAPVFADGVGLYAVAAAVILR-----G--SSGE-
SVSC-TIRSSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRSA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQY--------
--------------------------T---------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQKSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LKLPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDISF-S-EPLYPVFRILTLEST-------ALTIC-PAP-KEEESSS
NS--D-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------LKSRSSPA-FSNIFP-----LFGGLLLI--NL
FSPPPPRC-------------------------------------------HSPDG-FAV
--------P-APS-HPVLAAVGEAAVLPCCPDLGASAQPS-EVSWLQMPH-S---S-LVH
HYSEQKGQDRE----QTPEYRGRTEL-LMHRIRQGCM-DLRLSAVRASDEGQYTCL--VR
-R-G--ISYREA-QLE------L--K-VT-----AMGSAP-----------------HI-
------SMENIQ-G-GT-R---I--VCRSSGWYPEPQVLWRDSSH-QHIPS-E-------
------A-------------------EN-RSRDARGLFEAQSTLLVV-----G--STPK-
DLSC-VVRNTY-LNE-EK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-EDIPAV--------
--------------------------KAPVVADGVGLYAIAASVIMR-----G--SSGK-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIT-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMEYAATK-------------
----------------QEIS---------LR-----------EWR---KIQY--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MAQWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--WD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGDISFY
NATDGSH--IYTFPHTTF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-KQVESSP
-N--P--D-----------------------LVPD--------HSLETLVA------PGL
VNESGEPQAEATAL---LLPAHPGA-RTEALY----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------METT--GP---SLT--------RYF------VP
MLLLQ-MA------------------------------------------APSSEQ-FTV
--------T-GLR-GPILAPLRGIVELSCQLSPPQNAEHM-EIRWFRDRY-T---Q-PVH
LYNNGKDLHAE----TISRYVERTEL-LKEAIREGKV-TLRILNVSVDDDGQYHCF--FK
-D-G--AFDEEA-ITE------V--K-VT-----ATSLGI-----------------QI-
------LVHPPNTK-GL-L---V--ECNTGGWFPQPQMEWRDSRG-EIIPP-T-------
------S-------------------IS-HSQDTEKLFHMKMTLLLK-----Q--SSHR-
NVTC-CLRNPV-TGQ-EERTS-------IVLS-DQLFP-------WNIIWRLILGIILAL
LVI-FIMVPSVDL-HIRLQELQQNG---------S----SVCSRVCTKDC--LPN--GCT
DCLRKMRNPIVVGIIIILLS---IGVIASLISYLHHK---------------SRVPASDP
H---FQLD--T--------------------MWL-EDITV-ILCV-LTV-FITMII-S--
F-----IYFR--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FTV
--------M-GPT-QRVIAPVRGEAILSCRLTPKMNARTM-DVKWFQVDR-G---L-PIH
WYRGSRDGAES----EGPEYDRRTEF-QKENIAEGTV-TLKLHGVRASDEGLYKCL--FQ
-S-P--FYSNEA-QFR------V--Q-VA-----GTGSVP-----------------HI-
------HIEEDERR-GI-R---L--ICSSSGWYPRPRVRWKDPRG-HRLPP-A-------
------S-------------------EK-THQEGDGLYAAETSFVLA-----A--DSKE-
NVSC-FIQNPL-LDL-DKEMR-------ISVA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------R
S---LSAH--T----------------D----TRI-RH----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDCPRYSLSGV---AASFLFVL
LTIKHPDDFRVVGPNLP-ILAKVGEDALLTCQLLPKRTTAHMEVRWYRSDPAMPV-IMYR
DGAEVTGLPMEGYGGRAEWMEDS-TEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSV
LLQVAALGSSPNIHVE---------GL---GE---------------------------G
EVQLVCTSRGWF----------PEPE---VH---WEGIWGEKL-----------------
-MSFSENHVPGED--------------------------------G------------LF
YVEDTLMVRNDS----------------------------------VETISCFIYS----
HGLRETQE------------------------------VTI--ALSER-LQTELAS-VSV
--------I-GHS-QPSPVQVGENIELTCHLSPQTDAQNL-EVRWLRSRY-Y---P-AVH
VYANGTHVAGE----QMVEYKGRTSL-VTDAIHEGKL-TLQIHNARTSDEGQYRCL--FG
-K---DGVYQEA-RVD------V--Q-VM-----AVGSTP-----------------RI-
------TREVLKDG-GM-Q---L--RCTSDGWFPRPHVQWRDKDG-KTMPSFS-------
--------------------------EA-FQQGSQELFQVETLLLVT-----N--GSMV-
NVTC-SISLPL--GQ-EKTAR-------FPLS-DSKI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMTLPVVVL-PLAMA-------------
I-----DLIKVKR-RRTNEQT--------H-SSNQENNK---------------------
---------------------------------N-DE-N--HRRR---L-----------
--PS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-E----
--------------RL-----R--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLP
---V-------------------SLDSLKPV-------SLTSS------LVFLMHLLL--
---LQPGE------------------------------------------PS-SE--VKV
--------L-GPE-YPILALVGEEVEFLCHLWPQLDAQKM-EICWFQSHT-L---N-VVH
LYQEQQELPGR----QMQAFRNRTKL-VKDDIAYGSV-VLQLHSIVPSDKGIYGCR--FH
-S-D--NFSGEA-FWE------L--E-VA-----ALGSDP-----------------HL-
------FLEGFKEG-GI-Q---L--RLRSSGWYPKPKVQWRDHQG-QCLPP-E-------
------F-------------------EA-IVWDAQGLFSLETSVVVR-----E--GALS-
NVSV-SIQNLL-LSQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---VPGA--S----------------P----WKS-AFVAT-----LPPLLLVLAALA--
L-----GFLQKQRRSREKLKK--------QAEK-RQE---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PSLQ----------VS-----EDGKSVSSR---GAPP--AP-A------------PSH--
PQRFSEQTCAL-----------SLER FS---AG RHY---WE-VH-V------GRRSRWFL
GACLAAVP-R--A-GP--------------------------------------------
---------------ARLSPAAGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RLGVFLDYEAGKLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIC-PLP-VRGTCVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DPALD-------WW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MDFS
---V-------------------FLNSYQQG-------RLPSS------LFFLTHLLL--
--LLQPRV------------------------------------------LC-SEE-IRV
--------V-GHE-EPVLAHVGDEVEFSCHLSPYRDAEHM-EILWFWSQA-S---N-VVH
LYREQQEFHGR----QMKQFQNRTQL-ITDDIADGSV-TLRLHRVVPADQGLYGCR--FL
-S-S--DFTGEA-TWD------L--E-VA-----GLGSDP-----------------HI-
------FIEGFKEG-GI-Q---L--RCHSSGWYPKPQAQWRDHHG-RCLPP-E-------
------T-------------------EN-ITEDVRGLFSLETSVVVQ-----E--GAHS-
NVSC-SIQNHL-LGQ-KKEFV-------IHIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGT--S----------------P----WKR-AFLGT-LVG-LPLLLALLMMLV--
L-----YFFRKQRKSQEKLKK--------QAEK-D-K---G-KLTAE---L---------
-----------------GKLQVEL----DWRRAEGQ-----AEWR---AAQRHA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PGSAH
PSLE----------VS-----EDGKSVFSR---RTAL--GS---------------EN--
PQWFSEQTCVL-----------SRER FS---AG RHY---WE-VH-V------GRRSSWFL
GVRLAAVP-R--A-GH--------------------------------------------
---------------ARMSPATGYWVMGLW--N--------SCEYFVLDQH-R------V
--------------------------------PLSVRVPPR---CLGIFLDVEAGKLSFF
NVSDGSH--IFTFTDTF--S-GMLCAYFRPRAHDGS---EHPDPLTIC-PLP-VGEKRVL
EEE------DSDAWIQ----------------------------PY-ESS----------
-----NPALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MKKM--A-GFP-----ESF-----TSRYLL-----L
-LFFQLLT-------------------------------------------LGSAQ-FTV
--------I-GPA-EPILALEGEVAELPCHLEPKMNAEDM-EVRWFRSEI-S---P-PVY
VYLRGQELGTE----QMEEYRGRTAL-VRDTIDYGSV-ALRISSVKISDEGQYRCF--FS
-D-G--IVNEQA-LLE------L--Q-VV-----GEQHCPVQWFHG-----TGSVSSRI-
------CFRAGFLG-GP-VTWCY--DGAQGRSPPSHLLHWPFPQE-IFMFP-NHVF--PL
TKIVSNA----------------------------HCY----------------------
KPRK-MLNYPL-FTS-EDIF----V---NSIS-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPSS--L----------------S----LMV-ALSVT-LPV-----LGLLIAGG--
L-----LLIWKHSRDKGKAEG--------QNGEREGRHTG----------------ESS-
GAYLTYFYS--------FSFS----------EKLLL--Q--LKWS---RAQL--------
------------------------HKV---------------------------------
------------------------------------------------------------
--------------------------------------------DVT---L--D-PDTAH
PQLI----------LS-----EDWKQVIRGDT----L--QD-L------------PDN--
PKRIDVEPCVL-----------GRKGFT---TGRHC---WE-VE-V------GDNSAWGL
GICRENVG-R--K-GD--------------------------------------------
---------------IIMSPENGIWAVA-L--W---------GQYQAFTSP-L-----TP
---------------------------------LSLSTRPR---RVVVYLDYQAGDISFF
SGTDGSH--IYSFTHPTF-S-GTLLP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-S---A-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDMSRGNM-ALVIHNVTAQENGIYHCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--ECISRGWYPEPLTVWRDPYS-EIVPTLK-------
--------------------------EV-SITDADGLFMVTSAVIIR-----D--KSVR-
NVSC-SVNNTL-LGQ-EKETV-------IFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--S----------------P----WMV-SLAVI-LALFIIF-----MAV--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKEIAQQLQ--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------ELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPYR----QR-V------------PDN--
AERFDSQPCVL-----------GWES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---RVAIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-MPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTLHRVGMQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------FE--SF
VVCFFFLL-------------------------------------------YLIAS-LKV
--------I-GPS-QPLLVRVGEDIQLTCCLSPEANAQSM-EVRWVRAHR-Y---P-AVY
VYMDGDHVSAE----QMAEYRGRTVL-VTDAISEGRL-TLQIHNARTSDDGQYRCL--FE
-K-D--GVYQEN-TLD------V--K-IV-----GLGSSP-----------------RI-
------TMEGLADG-EM-R---L--MCSSEGWFPQPRVQWRDLEG-RTVPS-F-------
------S-------------------EV-LAQGSDGLFRVEAFLQVT-----N--SSAG-
NVTC-SIGNPL-FGE-E-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-LELLKEH-V---------ELWK--------------------------------TCVKP
HSQK-------------------MSVHMERL-SPS-----G-----SWLVGCLF-----T
IAIFQLPA-------------------------------------------QG-------
--------S-GSADKFYMAPLGSTANLSCPLRLWPNMAIS-QMRWHRPTHPPHP-Q-AVH
MFQDGQNSTED----LMPEYKGRTAL-VRDA-HKGSY-ILQISNVRFEDRGLYQCQ--VW
-V-G--NSSQED-NVT------L--Q-VA-----VLGSDP-----------------YI-
------HVKGYDAG-WM-E---L--VCQSMGWFPEPRTEWRDPTG-KALLSLS-------
--------------------------ET-HTLDEAGLFRTAVSSRIR-----G--NALG-
NVSC-TIRNKV-LGQ-EKTTA--------------------------------MLI----
------------------------------------------------------------
-----------------------------------------------------TAPDPGS
L---S-----S---------------------PA-VALSVV-LPI-----LGLLILLG--
I-----GLLCKQKKSREKLLYE--QVMEVE-NLLEDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANAGWRRARLHFVAVT---L--D-PDTAH
PKLV----------LS-----EDRRCVRLGNR----K--RS-V------------PDN--
PERFDFVVSVL-----------GSEY FT---TGC HY---WE-VY-V------GEKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKESPK---CVGIFLDYEAGVISFF
NVTDKSH--IFTFTHTF--S-SPLRPFFEPCLHDEG---KNTAPLIIC-TEL-QKSEESI
APKQ---------------------------------------------------EGKG-
-RANGDVSLKVNPS---LLSPQGSEF--FPLN---DA---WPSNLGPALQGLKVPSL---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LG
---S----S--------------GSGVMGTT--GV---LLV--------TNC------VV
LYLLL-IV------------------------------------------ALSSEE-FTV
--------T-GLS-RPVLASLGGTLELSCQLSPPQNAQHM-EIRWFRNHY-T---Q-PVH
LYRDGKDLHGE----TISMYVERTEL-LKDAIGEGKV-TLTIFNVTIDDDGPYHCI--FK
-D-G--EFYEEH-ITE------V--K-VT-----VTSSDI-----------------QI-
------LMHSPNTK-GV-M---L--ECHSGGWFPQPRMEWRDSKG-EVIPA-T-------
------S-------------------KS-HSQDRNKLFNMTMALFIE-----A--SSHK-
NVTC-YLQNHL-THQ-EESIN-------IVLS-GELFS-------WKCVWMWIMTMIASV
LIA-FIVTYCVQQ-YLIYEIVG---EEL----LPSAYSVQFKVDLSNCDQ--SEG-----
-ICSERFSYLLKGSVLLITS---VLAIMGVMLILHRE---------------QRVTVSDP
R---FELD--T--------------------LWL-EDISV-ILCM-LIG-YIIKLL-S--
F-----IYFRL-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----MVSH-------------------------------------------TGSEQ-FHV
--------I-GPK-APVIALVGEDVVLPCHLSPLMDAQSM-EVIWFQVHP-F---V-LVH
HYKNFQDHIEQ----QRPEYRGRTEF-LKDNITKGQV-SLRIHHIRPSDGGEYSCS--FE
-S-P--TYFNEA-NFQ------V--L-VT-----GSGTAP-----------------HI-
------HIDHGETK-GL-N---L--TCTSMGWYPEPEVQWRDLQG-QHLSP-A-------
------S-------------------ET-KTPERNGMFHVETSIMLD-----K--SSKE-
NVAC-YIRNPV-LSV-EKEG----H---ISLT-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---FPRV--S----------------P----WSV-AVPVIVVLL-----VIIGIIC---
V-----LLVRVRKSKVC------------YSTFIE----------IECR-----------
------------QRK-------F------LQRE---------------K-----------
------------------------------------------------------------
------------------------------------------------------------
-----------SEIAI-NK-------------------ILLETEDRK---L--D-RNTAD
PYHS----------VL-----DDTKCVTSMRQ----K--K--------------------
--IFPTLVDVL-----------GQNGFY---CGKHY---WE-VG-G--AG----KDCWG-
-----SVT-Q--KGQH--------------------------------------------
---------------ISAHLENGFWTLC-L--K--------NSVCTRLFPP-R-----YP
---------------------------------RNV------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MPVSP
---N---------------------------------SCLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AL-FDV
--------I-GPQ-EPILALVGEDIELPCHLSPNVSAEHM-ELRWFRKKV-S---P-AVL
VHRDGVEQEGE----QMPEYRGRATL-VKDNITAGRV-AVRIHPVRASDDGEYRCF--FR
-R-GE--IYEEA-KVQ------L--K-VA-----ALGSDP-----------------HI-
------HMEVQDRG-EI-Q---L--ECSSVGWYPEPQVQWRTPEG-EKFPS-T-------
------S-------------------ES-SNPDEKGLFTVAASLIIR-----D--NSLG-
NVSC-CIRNLL-LGQ-EKEVG-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AMAVI-LMV-----LGLLTIGS--
I-----FFTWRVYRQRSRERK--------NEFSPK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRETFT---SGRHY---WE-VE-V------GDRTDWVI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGAPR---RVGIFLDYESGDISFY
NMSDGSL--IYTFPMVSF-S-GPLRPFFCLWSCG-------NKPLTIC-PIT-YEPEGVI
VVAD----A------------------------QD--------PFKEIPLS---PIREDS
ASRDTDT---LHSK---LIPTQPSQG--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFQVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPL-GPILAMVGEDSDLPCHLFLTVSAETM-ELRWISSSL-R---R-VVN
VYADCKKMEDS----QGA----DSQE-FR-----------PI------------------
----------------------Y--P-ST-----ALGSDL-----------------HV-
------EVKGCEDG-GI-H---L--ECRSTGWYPQPQIQWSNIKE-ENIPAV--------
--------------------------EAPVVADGV-----AASVILR-----G--SSGE-
GVSC-IIRNFL-LGL-EKTAS-------ISIE----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRST--Q----------------S----WIA-ALEGT-LPI-----SLLLLAGA--
S-----YFLRQQQKEKIAL---------SRETERERKMREMGLCLKG-------------
----------------EWSV---------EKNKNT--------------DLFLI------
----------------------C-------------------------------------
------------------------------------------------------------
---------VS--------------------FLSEWKMALFKPAYVI---L--D-PDMAN
AILL----------VS-----EDQRSVQPAEE----P--HD-L------------PDD--
PARFEWRYCVL---------------------GRHY---WE-VE-V------GDRKEWHI
GVCSKNME-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYQ--------------
--------------------------------------------KVGIFLDYETGEISFY
NATDGSH--IYTFLHASF-S-EPLYPVFRILILEPT-------ALTIC-PTP-KEVESSP
D---P--DL----------------------M-PD--------HSLETPVT------PGL
ANESGEHQAEVTSL---LLPAQPGA-EGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIVEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-R---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TFVK-
NVSC-YIQNLL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWR---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSH--IYTFSNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PIG-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDS
ASVDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MLNFLGYSLSGA---AVSFFFIL
LTIKPSDDFKVISPAHP-ILARVGEDALLTCQLLPQRSAQHMEVSWYRSEPGIPV-LARW
DGAEVAALQMEEYRGRVEWIED-DIAKGSVALRIYNIQPSDNGQYWCRYQE-SYYG ETSL
QLKVAGVGSAPDIHME---------GH---VK---------------------------D
GIQL LCTARGWY----------PKPQ---VY---WEDKSGEKL-----------------
-LTVSEHHIQEED--------------------------------G------------LF
YVEGFLLLRDAA----------------------------------VETVSCFIHN----
ADLEEEKG------------------------------SEI--SIPEK-LRTELAS-LQV
--------I-GPA-QPILVTVGEDIQLTCYLSPKANAQSM-EVRWVRHHR-H---P-AVY
VYVDGDHVAGE----QMQEYRGRTAL-VSDAIDEGNL-TLQIHDARISDAGQYRCL--FE
-K---DGVYQEA-SFD------L--K-VA-----GLGSSP-----------------LV-
------TMEGLKNG-EK-Q---L--MCTSDGWFPQPQVQWRDGEG-KALPSFS-------
--------------------------GA-LTQGSHGLFHVETSLVIR-----N--HSTA-
SVTC-SISNPL-LGQ-EKMAT-------FSLS-ESRM-----------------------
------------------------------------------------------------
-----------------------------------------------------------P
S---------S---------------------WKMLLIFGS-LFAGA-------------
V-----VLSGRKRYKKGKIEE--------K-FDVEEDRL---------------------
---------------------------------KLRE-P--FEKI---KH----------
-LQS--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------N------
--------------HC-----PL-KSI---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDGITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSIGWYPQPQIKWSDTKG-ENIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--SSGG-
GVSC-IIRNSL-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMGYAATE-------------
----------------QEIS---------LREKLQE-E---LKWR---KIQYMA------
------------------------------------------------------------
------------------------------------------------------------
----RGEK-SL--------------------AYHEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GCEN FT---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTEP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHASF-S-EPLYPVFRILTLEPI-------ALTIC-PIP-KEVESSP
-D--P--D-----------------------LVPD--------HSLETPVT------PGL
ANESGEPQAEVTSL---LLPAQPGA-EVSPSA--------T-TNQNHKLQARTEALY---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---S---------------------------------SGLP---------RCL-----LT
LILFQLPK------------------------------------------LDS-AP-FDV
--------I-GPL-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-C---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERPRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSD--IYTFSNVTF-S-GPLRPFFCLWSSG-------KKPLTIC-PIA-DGPERVT
VIAN----A------------------------QD--------LSKEIPLS---PMEEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------LD---LALML-----VSVLLTVH--IY
TFLPSLLG-------------------------------------------HSAAQ-FTV
--------V-GPD-QPVTAVVGEEIVLPCHLAPRMSVENM-EVTWFRSEL-S---P-FVH
HYSDGKNQYEQ----QMPEYQGRTEL-LNDGLTQGNV-TLKIFNVTVSDEGRYSCF--VQ
-D-G--TFYEET-LLE------L--K-VA-----ASGSAP-----------------HV-
------SIEDYQDG-GI-R---V--VCRSAGWYPEPEVTWRDLNG-QAFPS-V-------
------S-------------------QT-NSQEANGLYETQNSAVIM-----E--NSNR-
NLSC-LVRNTR-LSQ-EREST---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--N----------------P----WMV-SLGVT-LVV-----LLGSFALS--
V-----YLFRIKAPTHTQRRE--------GGP--TR---D-TCPMGYAPT--DCEI----
--------G-LRDRPLQETYWRSG---WVLGGG---------------------------
------------------------------------------------------------
---------------------Q--------------------------------------
--------GSLRCLAW-R------------------R-NIVCPANVT---L--D-PDTAH
PQLI----------LS-----EDGKRVRWEQT----W--QL-M------------PNN--
PERFNSHRCVL-----------GREGFT---AGGHY---WE-VE-V--GD----GNYWAV
GVARESVS-R--K-GA--------------------------------------------
---------------INLGPQAGIWAVE-R--N--------WDKFQALTVP-C-----IP
---------------------------------LPLS-HPS---RIRVCLDCDGGQVTFI
DAGTEAP--IFTFPPGSLPA-ERIRPWIRV------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MAVSLA-TRPALRMGSR-GLRQISP---------------
-----------------------------------------SPALG-----S---NPHI-
------HLEGYKDG-GI-QL-----GCSSAGWYPEPQVQWRDAKG-KM-VP-S-------
---LSKSQ---------------------P-HTLNDLFGVASSVIVQ-----E--DSVG-
TITC-SIRNPL-LNQ-EKGA----V---ISIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRA--S----------------P----SMV-ALSVI-LFM-----LVLLIAGG--
L-----YLLRKLQREKGGGGQ--------ADWMRSRGERG--------------------
--------------------------------KIQA--K--LSWR---LAQL--------
------------------------HAV---------------------------------
------------------------------------------------------------
--------------------------------------------DVT---L--D-PDTAH
PELI----------LS-----EDLKRVTRGDT----R--QT-L------------PDN--
PERFDVFPCVL-----------GHEGFT---SGRHY---WE-VE-V------GDRKSWGL
GICREDVA-R--K-WS--------------------------------------------
---------------SSESPENGFWALE-L--Y--------ENEYRALTSP-R-----TP
---------------------------------LSLTEPLR---RVGVYLAYEAGNVSFY
SGTDGCL--IYTFPHITF-S-GTLRPFFHLWFYDPT-------PMSIS-CVP-WSLRES-
--------L------------------------IL--------PPLRRPQKPSPEAGPAS
VTQKGDPLPGVDAP---LLPPPAQT-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVEFPGYSLSGV---IASYLFIL
LTMKPQDDLRVLGPAGP-ILAKVGEDALLTCQLLPKRSAAHMEVQWFRSEPRPAE-TAHQ
DGTEMVEVQMEKCRGRLEMIED-SVAEGSVTLKIHSVQPSDSGQYWCRFQDGDYLGEASL
LLQVAGLGSAPNLHVT---------RN---DE---------------------------G
RVQLVCTAEGWF----------PEPH---VY---WEDRWGEKL-----------------
-LTVSEHHIPDDS--------------------------------G------------LF
YVEDTLVVGDVSAA--------------------------------TETVSCFIHN----
PVLKDGKR------------------------------AVL--SLPEK-LQTEMAS-LKL
--------I-GPS-QPILVRVGEDTQLTCYLSPKTNAQSM-EVRWVRSLR-Y---P-AVH
VYVDGDHVAGE----QMSEYRGRTSL-VSDAIHEGRS-TLQIHDTRASDDGQYWCL--FE
-K---DGVYQEA-SLD------L--K-VV-----AVGSAP-----------------LI-
------TVEEQKDG-AK-Q---L--TCTSYGWFPHPRVQWRDTEG-T-MPSSP-------
--------------------------AA-LRQGGRGLFHVESLLLVT-----N--SSVV-
NVTC-SIINLP-LGE-EKTTA-------VVLS-EFKM-----------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---------S---------------------WKML------LLAVI-------------
I-----GLIWMKSYKKVNVTQ--------D-SNTAPLKP---------------------
---------------------------------TLAG-E--HRNM---TCE---------
-HSY--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------N-Q----
------------------------MSHRM-------------------------------
------------------------LT-----TTSTP---WA-RRGS---RQPRGIE----
------SL-R--T-GM--------------------------------------------
---------------REYGP----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FTV
--------V-GPA-GPILAMLGENVTLTCHLSPEKNAEDM-EVRWFRSQF-S---P-AVL
VYKGRRERTEE----QMEEYQGRITF-VSKDISQGRV-ALVIHNVTARENGKYCCY--FQ
-E-G--RSYDKA-IMH------V--R-VA-------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------ESFTP-------SLSPWTVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------S-LVILMLL-----VSG--I
I-----GLIKKLHRGKKC-VSA--------ENDSEYKERE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEEL-----------------------------PDVV---L--D-PDTAH
PELF----------LS-----EDGRSVRR--GPSR----QS-L------------PDN--
PERFDCRPCVL-----------GRES FS---SG RHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPENGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPVKEHLC---RVAVFLDYEAGDVSFY
NMRDRSH--VYTCPLSTF-S-GPLRPFFRLGSDDSP-------L-FIC-PVF-TGAQGVV
VPE--------GGLILHRAGPVLWSQGHVAKPW---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----LSFF-------------------------------------------H-TIR-VLP
--------W-GPG-HPVTATVGQDVVLPCHLSPQHDARSL-EVRWIRDEF-S---E-TVH
HYRNGEDLYGE----QMEAYAGRTEL-ARDGLSAGNL-DLRITGLRLYDDGRYICI--VK
-N-A--DSYDEA-TVD------L--E-VS-----ATGADP-----------------HL-
------YLGGYEAG-GV-R---V--LCQSAGWYPLPQLLWRGAHG-QHLPS-V-------
------S-------------------QK-HSKDQEGLFEIEGAIIVT-----G--SMEG-
PLSC-VVRNSR-LQQ-ERES----S---LHIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FHNA--Q----------------T----FIV-VLAL-VLVN-----LAVSIGLG--
V-----YLFRKKVSFPEKQAA--------ELGEYHCS-----WAQGEHQ-----------
--------------G-DVQSQEVP---HLLPHG----------------AAPGP----KL
GK----------------------------------------------------------
--------------ACP-------------------------------------------
--------GLSS--AP-DG-----------------LAPSVPTVKVT---L--D-PSTAH
SYLI----------VS-----EDQRSVRWESN----W--QQ-L------------PYS--
KGTFDNWCSVL-----------GREEFR---EGRHC---WQ-V-----DGEEGTHSLWTV
GVAKASVE-R--K-GW--------------------------------------------
---------------FNMTPEEGIWALQ-Y--D--------KGKILSLTSP-P-----TP
---------------------------------LSLSPVPT---RIWVCLDCTQGQVSFI
NADNGVK--IYTFKEASFNG-ESIRPWFWLGTPGIQLCLRDSA-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
----------------------------------------K---------SCL-----LF
LTLFQLSK------------------------------------------PDS-AR-FDV
--------I-GPA-EPVVAAVGADVELPCHLSPNVSAERM-ELRWFRGQA-A---A-AVL
VRRDGREQEAE----QGAQYRGRASL-VDADIAAGRV-AVRLHRVRASDDGEYRCS--FR
-Q-DA--SYEEA-SVH------L--Q-VA-----ALGSDP-----------------YI-
------RMEVQESG-EV-R---L--ECTSVGWYPEPQIQWRTSEG-EKFSS-T-------
------S-------------------ES-RNPDEEGLFSVAASVVIR-----D--PSMK-
NVTC-YIQNLL-LGQ-QKEVD-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----FPR-L-T----------------P----WMV-AVAVI-LMV-----LGLLTIGS--
I-----VCTWRLYKERSRHRK--------DEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------RVD VT---L--D-PDTAH
PHLS----------LS-----EDSKSVRLEDS----R--QE-L------------PEK--
PERFDSWPCVL-----------GCET FT---SGRHF---WE-VE-V------GDRADWAV
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPR-R-----TP
---------------------------------LPLVGPPR---RVGIFLDYESGDISFY
NMTDGSP--IYAFSNASF-S-GPLQPFFCLWSCG-------KKPLTIC-PIT-DGPERVT
VVAD----A------------------------KD--------FTKEIPLS---PMGQDS
ASGDTDT---LHSK---LIPTQPSQR--AL------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MVGESSTLRCHLSPEKSAEAM-EVRWFRTHF-S---P-AVL
VYRGGRERPEE----QMQQYRGRTSL-EGAGLGRGRV-ALVIHNVTAHEDGDYRCY--FQ
-E-G--RSYDQA-IVR------L--E-VA-----GLGSKP-----------------LM-
------EMKGQEDG-GI-R---L--ECTSAGWYPQPHAVWRDPYG-EVVPTLE-------
--------------------------EA-YTAGADGLFTVTLAMIVR-----D--NSVR-
NMSC-SISNTR-LSR-EVEAG-------IFIP-ESFMP----------------------
------------------------------------------------------------
------------------------------------------------------------
------ST--S----------------P----WMV-ALAVI-LPTLILL-----MAG--G
V-----CLVKKFQKEKEV-ESEEKEIA---------------QKKLG-------------
------------------------------------------------KELVA-------
------------------------------------------------------------
-----------KEKE---H-----------------------------------------
----QI-KEQLQELRW--------------------RRTLLHAADVV---L--D-PATAH
PELF----------LS-----EDRRSVFR--GTRR----QE-V------------PDD--
PDRFHLWPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVMAWAV
GVCRADLP-R--K-GE--------------------------------------------
---------------VA--AGGGVWALELF-----------GGQYRPLAVPAL------L
---------------------------------LPLREPLG---CVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-A-GPLRPFFRLGSDDSP-------L-AVC-PAF-VGAQGVT
VPE--------AGLVLHGEGARRGR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------PI------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WQV-AVAVI-LAV-----LGLLTTGS--
I-----VFIWRLYKDRFRERK--------SEFSSK-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VNVT---L--D-PDTAH
PHLF----------LY-----ADSKSVRLEDS----R--QK-L------------PDK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAV
GVCRENVI-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGSPR---RVGVFLDYDSGDVSFY
NMTNGSH--IYSFPSVSF-S-GPLRPFFCLWSCG-------KKPLTIC-SVA-DRPEKVT
VIAD----A------------------------QA--------LSKDIPLS---PTGEEP
ASGDADT---LHSK---LIPLQPCQK--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKLR--FS---YFF--------GYC------GY
FLFLK--V------------------------------------------MMSSGK-MMV
--------S-THK-GQVLARVGGQAELSCQVTPPRSVEYM-EVRWFKSGH-S---Q-PVY
LYRGSQGVSGE----AAPEYVNRMEF-VKEAIGKGKV-GLRIHNISISDDGLYQCL--FN
-D-S--AFGYVD-SMN------L--S-VA-----AVGLET-----------------QI-
------HIQAPGAD-GV-L---V--ECDSAGWFPEPQMEWRDSRG-KALPP-S-------
------S-------------------KS-YSQDEARFFHLKTTL-LT-----N--RSQG-
GILC-WISNPL-TGE-EKQIS-------VILA-NDLFN-------RDHIWMNLLICITLM
I--LFLL---WRC----------------------------------------------G
LWCHRVFNPEPIQILS--FL---ICTIVLFAVYLPLR---------------SRVSISDP
Q---FSLY--N--------------------SWI-TELLF-VIFF-LTQ-KLNFHETS--
I-----------------------------------------------------------
------------------------------------------------------------
-----------------------LHK----------------------------------
-ELWKQKR----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------LLGFLKQT-------PWCLT------IFF-T-YLL--
--FLQLWE------------------------------------------VN-SDE-VWV
--------L-GPE-ESILARVGEAVEFPCRLSSYQDAGYM-EILWFRTQV-S---N-VVY
LYQEPQGRSNP----QMAQFRNRTLF-EAYDIGEGSV-NLHILSVVPSDEGRYGCR--FL
-S-H--NFSGEA-TWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFNGE-GI-Q---L--QCSSSGWYPKPKVQWRGHQD-QCLSP-E-------
------S-------------------ED-ITQNAQGLFSLETSVIVR-----G--GTHS-
NVSC-IIQNPL-LPQ-KKEFV-------LQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRT--S----------------P----WKK-AFVGT-LVV-LPLCLVALAVLA--
L-----RYFYKQRRFQENRVK--------QGEQ-TEE-----------------------
------------------KLQTEL----DWRRSEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----NNRKSVSSR---LGVP--ST-A------------AGD--
PQRFSEQTCVL-----------SRER FS---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--S-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------RCEYFVLDPH-R------V
--------------------------------ALALRVPPR---RVGVLLDYEAGKLSFF
NVSDGSH--IFSFTDTF--S-GTLCAYFRPRAHDGS---EHPDPMTIC-SLP-VRGLQIN
EEN------DNDNWLQ----------------------------PY-EPL----------
-----DPAW---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------CR-------
--AALPLL-------------------------------------------HCPAQ-LRV
--------V-GPG-HSVTATVGQDVVLPCHLSPKRDAREL-EVRWIRRMI-S---E-TVH
HYHNGEDLYGE----QMGAYAGRTEL-SRDGLSAGSL-DLRITGLRPSDDGRYVCT--VE
-D-A--DAYNEA-VVE------L--E-VS-----ATGADP-----------------HL-
------SLGGYEAG-GV-R---V--LCRSAGWYPLPQLLWRDARG-QHLPS-V-------
------S-------------------QT-HSQDQEGLFEIEGAVTVT-----G--SVEG-
PLSC-VVRSSR-LQQ-ERES----S---LHIA-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FHNA--Q----------------P----WMV-ALAL-VLVL-----LAVSIGLG--
V-----YLFRKQVKKDTKLGK--------SS-SPKKE-----QA----------------
--------------------TEL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------AW-RR-----------------FLMSHNTVKVT---L--D-PDTAH
PMLV----------LS-----EDHRRVRRETE----Q--QQ-V------------PDR--
PERFDVRLCVL-----------GCEEFT---EGRHC---WL-VE---VEGERLKFSRWAV
GVARASVE-R--K-GW--------------------------------------------
---------------INRSPKKGIWAVQ-Y--Y--------EGQLMSLTSP-R-----TP
---------------------------------LSLFSIPT---RIWVCLDCSQGQVSFI
NADNGVE--IFTFTAASFSG-ERIRPWFWVETVGIQLCLKDSAPQTLS-PAL-GGSSTSS
ATPA---------------------------------------------SPLLDPAGP--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FPGFLKQW---------CSS------IFF-THLLL--
--FLKLGE------------------------------------------VD-SDE-IKV
--------L-GPG-ESMLALVGEPVEFPCHLSPYQDAEHM-EIRWFRTQV-S---N-VVY
LYQEEQGLSSP----QMTQFLNRTIF-EANDIADGSV-TLHILGVAPSDEGLYGCR--FL
-S-H--NFSGVA-MWE------L--E-VA-----GLGLDP-----------------HI-
------SLEGFNEG-GI-Q---L--RCSSSGWYPKPKVQWRDHQG-QCLPP-E-------
------S-------------------EA-IIQNAQGLFSLDTSVIVR-----G--GAHS-
NVSC-SIQNPL-LAQ-KKEFV-------L-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------QWR---AAQQYA----VV
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTTAH
PSLE----------VS-----DDLKSVSSR---PGAS--SI-M------------AHG--
PQRFLEQTCVL-----------SQER FC---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--L-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------SCEYFVLDPQ-R------V
--------------------------------ALALRVPPR---RVGVLLDYEAGKLSFF
NASDGSH--IFTFTDTF--S-GALCAYFRPRAHDGS---EHPDPLTIC-SLP-VRGPYAL
EKN------DSDNWLQ----------------------------PY-EPL----------
-----DPDWASDEA---LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEVP------TSLHLN-----QAISLLL-----
-PLLSLLV-------------------------------------------LVAAQ-FTV
--------M-GPA-SPILAMLGENVTLTCHLSPEKNAEDM-EVRWFRSQF-S---P-AVL
VYKGRRERTEE----QMEEYQGRITF-VSKDISQGRV-ALVIHNVTARENGKYCCY--FQ
-E-G--RSYDKA-IMH------V--R-VA-----GLGSKP-----------------FI-
------EMKGYEDG-GL-W---L--ECTSAGWYPEPHAVWRDPYG-EVTPSLE-------
--------------------------EA-YTVDRDGLFTVTMVVIIR-----D--SSVR-
NMTC-SISNTL-LGQ-EVETV-------IFIP-ESFTP-------SLSPWTVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------S-LVILMLL-----VSG--I
I-----GLIKKLHRGKKC-VSA--------ENDSEYKERE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------RRTLVHAADVV---L--D-PDTAH
PELF----------LS-----EDGRSVRR--GPSR----QS-L------------PDN--
PERFDCRPCVL-----------GRES FS---SG RHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPENGFWTLEMF-----------GNQYRALSSPEK------I
---------------------------------LPVKEHLC---RVAVFLDYEAGDVSFY
NMRDRSH--IYTCPLSTF-S-GPLRPFFRLGSDDSP-------L-FIC-PVF-TGAQGVV
VPE--------GGLILHRAGPVLWSQGHVAKPW---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------Q-FHV
--------T-SPN-KQLVAELGSNVSLPCTLSPPLSADGL-EVRWFHTIY-S---P-HVY
LLKDGKEDKEQ----QRAEYNGRVSL-LKG-PESGDL-TLSLHKVQLSDANNYVCF--VE
-N-KTSGVYEEA-FIQ------L--D-VV-----GEGSLP-----------------TL-
------DIS-LQDS-SV-L---L--SFSSSGWYPKPQMQWEKSEG-VSIAPNS-------
--------------------------VA-YLNQSDGLFRVESSILLK-----G--PYTD-
PLYC-RARHPI-TGR-DTGIF-------LRIS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVNFPGSSLCAV---AASFFFVL
LTVRQSDDFRVLGPGGP-ILARVGKDVLLTCHILPKRTAMHMEVRWYRSEPDTPV-CVLR
EGAEVTEVQMEEYRGRVEWMED-GVAEGHMTLKIRNVQPSDSGQYWCRFQEG DFYAEASL
LLEVAGLGSAPNIHLE---------GS---VD----------------------------
-VQLVCTAKGWF----------PEPQ---VY---WEDLWGEEL-----------------
-LTMFEHHVQDED--------------------------------G------------LF
YVEDTLVVRNAS----------------------------------AESVSCIIHN----
PIL TEEKR------------------------------SVI--DIPEK-LQTELAF-LKV
--------I-GPS-QPILVRVGEDTQLTCYLSPEVNAESM-EVRWVRSHR-Y---P-AVH
VHVDGDPVAGE----QMAEYRGRTVL-VSDAIQEGRL-TLQILSARPSDDGQYRCL--FE
-K---DGVYQEA-GVD------L--K-VV-----ALGSSP-----------------LI-
------TMERLKDG-DA-Q---L--MCSSHGWFPQPHVQWKDRDG-KPIPAFS-------
--------------------------ET-VTQDSHGLFHVETFL-VT-----N--ISAV-
KVTC-SLSSPL-LGE-EKAAT-------FSPS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------AAV-------ISCHN------LKECSHLLL--
--LFQPGK------------------------------------------LN-SEE-VKV
--------L-GPD-HSMLALVGEEVEFSCHLSPYLDAEHM-EIRWFRSQT-S---E-VVH
LYQHGQELYHQ----QMTQFHNRTKL-LKDDIAVGSM-VLELHSIVPSDEGPYGCR--FL
-S-S--DFSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEVFKEG-GI-Q---L--RCSSHGWYPKPKVQWKDHQG-NCLSP-K-------
------S-------------------EA-INQDAQGLFSLETSVVVK-----G--GAHR-
NVSC-FIQNPL-LVQ-KKEFV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------EV
PRSSLTRK--A----------------P----WIP-RSLVA-----LMFLL--LLCRG--
V-----IFFEKKLYHQEPQSQ--------SC-----------------------------
------------------NFSPSI-------NFICF-----MKWR---AAQQYA----VK
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PATAH
PSLE----------VS-----EDGKSVCSH---GIAP--NR-V------------PDD--
PQRFSEQTCVL-----------SQERFS---VGRHY---WE-VH-V------GRRSRWFL
GACLATVS-R--V-GP--------------------------------------------
---------------TRLSPAGGYWVMGLW--N--------DCEYFVLDPH-R------V
--------------------------------ALTLRVPPR---RVGILLDCDAGKLSFF
NGSDGSH--IFTFTDTF--S-GELCAYLRPRAPDGT---EHPDPLTICTL----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MDLKF-----------------------------VFLI--CL------IPAAS-AIL
--------V-VES-GKLITLLASDVELPCTLSPPSREVGL-EVRWFHTVF-H---S-VVY
LLKDGREDRQQ----QNTEYRERAFL-KSG-PQTGNL-ALSLLKVRLSDAGTYHCF--VE
-N-ETAAYDEED-FVK------L--V-VI-----GPGSPP-----------------LV-
------KVS-LQDS-SV-Q---I--SCSSSDWFPEPTVNWKTDDE-AFVNEEM-------
--------------------------TT-SHKQTDGLFSVTNNILLK-----D--SSEG-
NLFC-TMKHPV-TGK-ESGVY-------VIVS-ESMF-----------------------
------------------------------------------------------------
-----------------------------------------------------------P
R-------LSH---------------------WAILFFVLL-V----------LSLGA--
F-----AFVGWKFYAYCIEKE--------KQLSSKENIL---------------------
------------------------------T--LQKQ-E--LEWR---KAVVYK----VE
SIHF--------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------D-PHSAF
RRLV----------VS-----PD-KYVISPA-----EQEQD-V------------TSG--
EDRFDTEPCVL-----------AQSSFD---SGKHY---WE-TEI-----QERSGKFWSI
GIAKQTVR-R--S-GG--------------------------------------------
---------------QRECPEAGIWAIRAS-----------SDCFLGLSTPPTEIF----
-----------------------------------PSQRPV---LVGIFLDYEEGMLTFY
DVNTFQL--LFTFQDKDIAE-EPVFPFYYVGNGI-T-------FVLKH------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------VKMASSS-----R-----SWLSRCLI-----T
LVFLQLPL-------------------------------------------HV-LD-R--
--------T-GDAGQSHVAPLGGTAELLCPLPLWPVTIPS-GVRWLRTPGLG-LSQ-FVH
VFREGKXXXXX----XXXXXXXXXXX-XXXX-XXXXX-XXXXXXXXXXDRGRSRCQ--VQ
-I-G--NMSREG-AVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQG----
------------------------------------------------------------
-----------------------------------------------------AAPSPAR
F---S-----S---------------------SE-VALAVI-LPV-----LGLLIIVG--
V-----NFIWKQRKSKEELLYE--QVMEVE-NLLSAHAKEK-GR----------------
---------------------------------LR-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSDLKL-----------KRAAANSXXXXXXXXXXAVT---L--D-PDTAH
PKLI----------LS-----EDRRCVKLGDT----R--KP-L------------PDN--
PQRFDFIVSVL-----------GSEYFT---AGCHY---WE-VY-V------TDKTKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQN----------CGNEYEALTSPQT------S
---------------------------------FRLKEPPQ---CVGIFLDYEAGVISFY
NVTDQSH--MFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKLEGST
VPKP---------------------------------------------------EDKG-
-HANRDVALKVDPS---LLPAQTPEL--FPLR---DRILSWPSDLGPALQGLRVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------FMV
--------I-GPS-EPIVAVLGADITLPCLVSPAMDVENM-ELWWFPSKF-S---G-AVL
IYQNQREQTEE----QLAEYRGQTSL-VKDFLTQGEA-AVRIHHVQAFDNRLYTCF--FQ
-M-R--IFYEEA-SVE------L--K-VA-----GAGSAP-----------------QV-
------HITGPEKD-G--R---I--VCMASGWFPKPQVQWRALSG-EKFLT-F-------
------S-------------------ET-QA---QGLFTIKAILVVR-----D--SSSG-
NVTC-SVLNPI-LGQ-EKAMA-------MFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FSWS--S----------------P----WKL-AFMVI-LTV-----LMLLLLGA--
A-----FYIMREHTAKLQEMQ--------EWEKPHRE-QEEDQQIKEEA-LKAR------
------------DE-LQ----GDLA-----HRFLCC--L--ADWR---KSVYLP------
------------------------------------------------------------
------------------------------------------------------------
--------------DW-QK------EKFQAW-QVLKLLVTVSAVTVS---L--D-PESAH
SSLA----------VS-----DNKTSVTWKNLPK--G-----------------------
--S-------------------------------EH---WE-VE-IRNAE-RS---EWAL
GVCRRDVE-K--N-GW--------------------------------------------
---------------NQESPEKGFWVVG-M--Y--------GYTFSS--LPYI------S
---------------------------------EHVVPIPQ---RVGD-LDLEKGDVSFY
NMTDGSH--IFSFPLTYS-S-GTLFPYFRLRSGD-V-------SLTI-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MPRT-QGGA-NSLCSS----LTV---LLF--LE
LLPVG----------------------------------------------NGKAD-FQV
--------L-RPQ-DPALAVVGEQAELRCWLSPNISAHSM-ELRWFL----S---P-AVH
VHRPGLDELEE----QMAEYRNRTSF-VDLNLAGCQA-AVRTHRVTLSDNGSYHCL--FM
-E-D--TAHDST-TLW------L--Q-VA-----GLGSSP-----------------RI-
------QVIHTQNR-GV-W---A--EYASEGWYPEPWVEWRNQRG-QMVHA-E-------
------T-------------------NF-SVLATTGLLAVVSRVALL-----D--RAVE-
GLSC-SITSPL-LPE-RK------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MANFL
---VS-------------------MEFLKRV-------PLPSS------LLILTQL----
LLFLQLGK------------------------------------------AD-SGK-VKV
--------V-GPG-ESMLALVGEEVEFSCHLSQYMDVEHM-EILWFRGQT-S---D-VVH
LYQDGQELFGG----QMVQFQNRTKL-LTDEMAIGSV-ILQLHNVVPSDQGPYGCS--FL
-S-S--SFSGEA-IWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPQALWRGHQG-QCLPP-E-------
------T-------------------EA-IVQDVQGLFHLETSVVVQ-----G--RAHR-
NVSC-SIQNPL-LIQ-KKEFV-------VQIA-GQLDAHSPLIAPWGPKWVAAEA-----
----------------------LCHGNLHSKI---TTWYTQDRAACPSAPT---------
------------KGRG-----------------GGVTTQGAARGVWS--LIWVSWCFPDE
F---FPGA--S----------------P----WRS-AFLGT-LAA-ALLLLLFLAALA--
R-----LQ--RRHRGER-LGR--------GRR----------------------------
-----------------------------CR----G-----REWK--------A----AQ
Q-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------Y----------AAH
PNLE----------IS-----EDGKSVSTRPG---P---PS-P------------VAS--
DPWFSQHKCVL-----------GREQFS---SGRHY---WE-VH-V------GRRSCWFL
GVCLAAVP-H--S-GP--------------------------------------------
---------------ACLSPASGYWVLGLW--N---------CEYFALDPH-R------V
--------------------------------ALTLRVPPR---RVGLLLDCEAGTLSFF
NVSDGSH--IFTFSDSF--S-GALCAYFRPRAQDGS---EHPDPLTIC-SLP-IKDTCTL
EDN-------SDTWLQ----------------------------PL-TLS----------
-----DPTQV-------L------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MADCPGYSLSGV---AASLLFIL
LTVKHPDEFRVVGPAHP-VLTRVGEDALLTCQLLPKRTTAHMEVRWYRSDPNTPV-IAHR
DGAEVSGLQMEGYRGRAEWTEDS-TDEGSVALKIRQVQPGDDGQYWCRFQEGDYWREASV
LLQVAALGSSPNIHVK---------GP---GD---------------------------G
GVQLVCTSQGWF----------PVPE---VY---WEDTREEKL-----------------
-LSFSENHVLGED--------------------------------G------------LF
YVEDTLVVRNDT----------------------------------SETISCLIYN----
HGLKEAKE------------------------------ATI--ALPEK-LQTELAS-SRV
--------I-GPS-QPILVQVGENIELTCHLSPRTDAQSM-EVRWVRSHY-Y---P-AVH
VYVDGAHSAEE----QMVGYRGRTVV-MSDAIHEGNL-TLRIHDARPSDDGQYRCL--FG
-K---DGVYQEA-RMD------V--Q-VM-----AVGSTP-----------------RI-
------TQEVLKDG-GV-Q---L--RCASDGWFPRPHVQWRGRDG-KAIPSFS-------
--------------------------EA-FHQESEGLFQVETLLLVT-----N--NSVV-
NVTC-SISLTG--GE-EKAAR-------FPLS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPT------TSLRSC-----PLASLLF-----
FLVLSLFV-------------------------------------------LVSAQ-FTV
--------I-GPA-EPILAMVGENTTLHCHLSPERNAEEM-EVRWFRWRF-F---P-AVL
VYRGHRERPEE----QMVAYRGRTTF-MRTDISKGRV-ALIIHNVTAYDNGIYCCY--FQ
-E-G--RSYDQA-TTK------L--M-VA-----SLGSEP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPEPRAVWRDPYH-EVVPALE-------
--------------------------EE-YIADREGLFTVTMTIIIR-----D--CSVR-
NMTC-SVNNTL-LSQ-EVESV-------ILIP-ESFVP----------------------
------------------------------------------------------------
------------------------------------------------------------
------SL--P----------------L----WMV-AVAVT-LPVVMLILL---TSG--S
I-----CLVKKHRRKKSI-LS---------------AEKEAEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----EAARQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----DDQRSVIR--GSSR----QS-V------------PDN--
PERFDCRPCVL-----------GRES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GSQYRALSSPEK------I
---------------------------------IPLKERLH---RIAVFLDCEGGDISFY
NMRDRSH--IYTCPPVTF-T-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLFLYKTRPISQSLVRKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGIYCKPS-----VLF---QDS-YLL-------
-VLTQLLC---WVT---------------------------------------TKG-FRV
--------F-GPS-DPVVVAPGREAILPCSVSPAMSVENMEELRWFRTRF-S---E-AVF
VYRDQEEQKEE----QMIEYSLRTSL-VKDQFHEGKA-AVRIQNVQESDSGIHVCH--FK
-Q-G--VLYEEA-ILE------L--K-VA-----AMGSTP-----------------EV-
------YIKGPEDG-GV-C---V--VCMTSGWYPEPQVHWRDSTG-EDLPA-S-------
------S-------------------ET-LHEDAEGLFSTETSLVLR-----D--SSVR-
NVAC-SIFNPV-LGQ-EKAIA-------IVIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFIVI-LTM-----MGLLVSGT--
S-----YLLIREHSGRLKLQQ--------EWSHFQLE-KDELQTIKEDA-L---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDTA------AAPHFS-----LPGSLLL-----
-LLLSLCA-------------------------------------------LVSAQ-LTV
--------V-GPA-SPILAMVGENTTLHCHL-------------WFRSQF-S---A-AVF
VYKGGRERTEE----QMEEYRGRITF-VNKGISRGSV-ALVVHNVTAQENDIYRCH--FQ
-E-G--WSYDKA-ILR------L--V-VA-----GLGSKP-----------------LI-
------EIKAQEDG-SI-W---L--QCISGGWYPEPLTAWRDLYS-EIVPTLK-------
--------------------------EV-SIADADGFFVVTTAVIIR-----D--KSVR-
NVFC-SIENTL-LSQ-EKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--T----------------P----WMV-SLAVI-LAVFLIF-----MAM--S
I-----CCIKKLQREKKI-LSG--------EKEVEQEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------R-TFLHAA--P---K--N-PNTTH
PELF----------LS-----EDQRSVRQ-------------V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTV
GVCGDGVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEVF-----------GNQYWALSSPDR------I
---------------------------------LPLKESLC---WVPIFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRIGSGDSP-------I-FIC-PVL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MMDFP
---V-------------------SLDSSQRA-------PLPSS------LFFLVHLLL--
--LLRSGE------------------------------------------LN-TEE-IKV
--------V-GPG-EPIMGIVGEEVEFPCYLSPDMDAEDM-EILWFRSQA-S---D-VVH
LYQERQELFSL----QMADFQNRTKL-IKDEIQDGHV-ILQLHSIVPSDEGLYGCR--FL
-S-S--NFSGEA-IWQ------L--E-VA-----GRGSAL-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSRGWYPRPKAQWTDPQG-RCLPA-E-------
------F-------------------EA-IIQDTQGLFSLETSVVVQ-----G--GAHS-
NVSC-SIQNTL-LAE-KQESV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------P----WKG-AFLGT-LVG-LPLLLALLSTIA--
L-----YFFQKQRRTQETLKK--------QAEK-EKG-----------------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQQYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
PDLA----------IS-----EDGKSVWSR---EAAS--GA-A------------AGA--
PQRFAGQTCVL-----------GRERFS---AGRHY---WE-VH-V------GRRSRWFL
GACLAAGP-R--A-GP--------------------------------------------
---------------ARLSPAGGYWVMGLW--N--------GCEYFVLDPH-R------V
--------------------------------ALSLRVPPR---RVGVLLDFEAGKLSFF
NASDGSH--IFTFADTF--S-GALCAYFRPRAHDGS---DHPEPLTIC-PLP-AKWTCVP
EDD------DRD------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MG------TPRD---------GFPYWNSKVK
TF-------------------------------------------------KDRHF-WHS
--------I-DEN-GKFPGL--PSAQLSCLLLLGPAAHSL--LSSVFCAW-T---L-WAH
PGHDGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------DMKGYEDG-GI-H---L--ECRSTGWYPQPQIRWSNDKG-ENIPAV--------
--------------------------EAPVFVDGVGLYAVAASVILR-----G--SSGE-
GVSC-TIRSSL-LGL-EKTTS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FRRA--Q----------------S----WIA-ALAGT-LPV-----LLLLLGGA--
G-----YFLWRQQEEKKTL---------FRKKKREQELRELAWSTVK-------------
----------------QEKS---------TREKLLE-E---LRWR---SMQYT-------
------------------------------------------------------------
------------------------------------------------------------
----VLGERPS--------------------AYNEWKKALFKPADVI---L--D-PKTAN
PILL----------VS-----EDQRSVQRAKE----P--QD-L------------PDN--
PERFDWHYCVL-----------GCES FM---SG RHY---WE-VE-V------GDRKEWHI
GVCSKNVQ-R---KGW--------------------------------------------
---------------VKMTPENGFWTMGLT--D--------GKKYRTLTEP-R-----TN
---------------------------------LELPESPR---KVGVFLDYETGDISFY
NAVNGSH--IHTFLDVSF-S-EPLYPVFRILTLEPT-------ALTIC-PAP-KEEESSS
NS--D--RV----------------------VIIR--------CLPRDTSD------PGL
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------CGFP---------RCL-----LT
LILLQLTQ------------------------------------------LDS-VP-VNV
--------T-GPP-EPVLAVVGEDAELPCRLSPNASAESL-EVRWFRRTV-S---P-AVL
VHRDGREQEAE----QMPEYRRRAAL-VQDGLAEGRV-ALRIRSVRASDDGEYTCF--FR
-E-DG--SYQEA-LVR------L--Q-VA-----ALGSDP-----------------HI-
------TMQVQENG-EI-Q---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVN-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMI-----LGLLTIGS--
I-----FFTWRLYKERSREKN--------NEFSSK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------IY-----EDSKSVQLEDS----H--QK-L------------PEK--
PERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGRPR---RVGIFLDYESGDISFY
SMNNGSH--IYTFDNASF-C-GPLRPFFCLWSCG-------KKPLTIC-PVA-DGPEGVT
VIAN----V------------------------PD--------LSKEIPLP---SMGEDS
ASRDADT---LHSK---LIPTQPSQG--VS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------G-FVV
--------I-GPT-EPVVAMLGADTLLPCRVSPPMSVENM-ELRWFRSEF-S---E-AVY
VYQDGMEQVAE----NWT--SGRAEL-IKDYITEGRV-GVRIHSLRVSDNGMYKCF--FK
-K-G--SDFEEA-VLE------L--K-VV-----GLGSGP-----------------YI-
------LMVGPEDE-GI-R---V--TCTGKGWFPQPEVQWRDERG-EKIPT-V-------
------E----------------------EIQDDDGLFQMEASLIVR-----D--SSKR-
KISC-SMKR---FCE-EQVET-------ISIP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---NRQ------------------------V------SCLL---------AFL-----LQ
LLVLQLPT------------------------------------------LDS-AP-FHV
--------T-APQ-EPVLALVGSDVELTCLFSTNESAEHVEELRWFRQTR-S---P-AVL
LYRAGQEQEDQ----QMTEYRGRATL-VTDGLPDGRA-TLLIRGVRVSDQGEYRCS--FK
-D-ND--NSEEA-SAH------L--K-VA-----ALGSDP-----------------HI-
------SMEVKENG-QI-Q---L--ECTSSGWFPEPEAQWRTPSG-GRLPF-T-------
------A-------------------ES-RNHDEEGLFTVAASVIIT-----D--SSIK-
NVSC-CIQNHL-LGQ-EKEVE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIV-AVAII-ILA-----LGFLTIGS--
V-----FFTWRLYKERSRGKK--------SEFGSK-------------------------
-------------------------------GCKKT--------------ALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVCLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYESGDISFY
NMSDGTL--IYTFPSTSF-S-GPLRPFFCLWSSG-------KKPLTIC-PTA-NGPGKIT
VIAN----A------------------------QD-----------SIPLS---PLGEGS
ASGETDT---LHSK---LIPFSPSQV--VP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDILGYSVPGT---IASFFFIL
LTLRRSDDFRVLGSSQV-LLALVGEDALLTCQRLPNGTAAHTEVRWYRSEPSTPI-IAYG
YGAEMIEVQMEEYRGRVEWIDD-GIAEGRVALKIHNIRPSDNGQYSCHLQEGSHAGEASL
LL KVAGLGSA PQIHMN---------GS---VE---------------------------G
GIQLVCTAKGWF----------PEPR---VR---WEDSQGEQL-----------------
-LSLSEHYIQDAN--------------------------------G------------LF
YVEA TVLVLGAS----------------------------------PESASCIIHN----
PVVSEERV------------------------------ATI--TLPEK-LQTEMAS -LKV
--------I-GPS-QPILVRVGEDVGITCYLSPKANAQRM-EVRWVRSRR-Y---P-AVH
VYMDGSDMAGE----QMEEYTERTSL-MSDAIQEGRL-TLKIHNTSISDDGQYRCL--FE
-K---DGVYQEA-SVN------L--K-VV-----GMGSSP-----------------LV-
------TM---KEG-EK-Q---L--KCTSDGWFPEPQVQWMDRDG-NMMPAFS-------
--------------------------EA-LTRGSHGLFHVETVLLVE-----S--NIIV-
NVSC-CISNPL-LGK-EKRTT-------FSSP-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---PGL------------------------YCKPPL-PSLPIT------ERNHL------
--YTQLIE-------------------------------------------HFTAQ-FSV
--------T-GPD-RPVGAVVGGEAVLSCHLSPQMSAANM-EVRWFRSQF-S---A-AVH
LYRDGQDQYKE----QMQEYQGRTEL-LKDNITEGRV-SLRIRNIRPSDEGLYKCF--FQ
-S-S--DSYEDA-LLE------L--Q-VA-----ALGSAP-----------------DV-
------LVEGHEDG-GV-R---V--VCRSSGWYPQPEAQWRDLQG-KHLPS-D-------
------S-------------------EK-IFPMASDLFQTEIAIVLR-----E--ESNQ-
KVSC-HVWNPR-LDQ-ERESI-------ISIA-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------L
F---FPRV--N----------------P----WMV-SLGVI-LAL-----LAVLIPLA--
S-----YCSWRQHRAKGKVRK---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MDK----------------------------RADLG
---S----T--------------NSGVMGAV--GI---PLT--------AHC------VV
LFLLQ-MV------------------------------------------ALSSEQ-FTV
--------N-GLE-SPVLVPLDGNLELSCQLSPPQQAKHM-EIRWFKNRY-S---E-PVY
LYRNGKDLFGE----IVYKYVERTEL-LKDDIGKGKV-TLRIFKVTSVDSGSYHCF--FK
-D-G--KFYEEH-IID------V--K-VT-----ATSSDI-----------------QI-
------LMHPPNIK-GV-R---L--ECHSGGWFPQPHMEWRDSKG-EYIPA-T-------
------S-------------------KS-HSQDENEFFNMTMDLFIK-----S--NSHW-
SATC-YIQNFV-THQ-EESIS-------IVLP-GVWDS-------WCPAWIMITLLIVI-
-----HMTYYIKL-YRTYATKEMLLKSI----QSSSQSSTV-------------------
---DTEKKEWLLKSIQSRIQSSSVDAEKKEWLLKFIQ---------------SSIQSSSV
D---LEKK--EWLLKSIQSSIQSAIVDRGTKEWLLESIQSSILSS-IVD-QGTKVL-L--
L-------KSIQSSI--------------QSSTLDIE--------TKELLLKSI-Q----
-------------SSIQSSIM-DL------G-----------------TKEL--------
--LLKIIQSSIQSSSVD-----LGTKELLL-------KIIQSSIQSSTVDLGTKELLLKI
IQSSIQSSSVDLGTK---------------------------------------------
-------ELLLKIIQS-----------------------SIQSSTVD---L-------GT
KELLLKIIQSSIQSSSVDLGAKMGLLESILSS----I--QS-------------------
-SNVDLETKVL-------LLKSIQSSIQ---SSTVY----------------LGIKQWLL
ERIESIIQSS-SV--YLDTKELLLKIIQSSIESYSVDLGNKEFLLKIILSSIQSSSVDLG
TKELLVKFFQSNIQSSSVIPGTKKLLVKIIQSSLQSSSVDLGTKKVLLDIIQT-----SI
---------------------------------QNSNVHTE---RKGLLLKIIQSSVQSS
SVDQGTKEMLLEIIQSSIQN-----SSVNQWTKDL--------LLKIIQSII----QSSS
------VDLGTKGFLLKI---------------IQ--------SSI------------QS
SS----VDIGTKSM---LLKK-------------TGLILKS-SIVNPG----TELLFQLI
ESIRHSSSVNSETKKMLSEITQSTVQSSSVNPVTEEMIEEKYQLLLQSSSVNLEAENILN
VTTQWILQISSVNQGKEMLLLDKIQQILQISSVNPETKDLLLEKIELILQNPGVHQETKD
LLLERIQLILQNSSVQKETKYLLLERIRSILQSSCVQKETKDLLLERIQSLLQSSCVQKE
TKDLLLEKIQLILQNSTVHQETKDLLLERIQLFLQNSTVDQETSYLLLKRIQLILQSSSV
KKETKEFVLYIIESILHSSSVHQETKDLLFDRVQLILESSSVQQGLKCLLLNMIQVIFQR
TSVQKEMKDLLFNRIPLILESSSVQQETKDKLLDIIQSILQRTSVQEETKDKLLDIIQSI
LQRSSVQKDTIDTLLDRIQLILQRTSVQKEMKDFLLDRIKSILESFSVHQETKKLLLNRI
MSILESSTVHQETKKLLLERIQSILESSSVQQETKKLLLDRIHSILKSSSVQKETKNLLL
DRIHSILKSSSVQKESCNKRNPFWKKYALDLGISVFTIIVVTLIMHLKQREADQHFELNT
LWSKDTSVILCVLIMFNNRLKALIYFRLYGFSPPGKAHKYIVNYILRFSHPVFCIVYSAT
ILYMYLQIQNKDSLFSLYNSWMVEMEMVLIFLLVIFNVKNIATVLLYFDSTTLRLFFWIK
G

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-M----------------------------------------------------------
--------------HC---FC---------------------------------------
--------------SC-FA-----------------VEEDANPVKVT---L--D-PHTAH
PLLF----------LA-----EDHRSVSWESE----W--QS-F------------PST--
EERFDIRCCVL-----------GREEFR---YGRHC---WR-VV---SWEKRGRFCSWAV
GVARASLK-R--K-GK--------------------------------------------
---------------ITMCPEEGIWAVQ-Y--R--------EGHLMSLTLP-R-----TR
---------------------------------LRLSPVPT---KIWVCLDCTQQQVSFI
NANNGVE--IFTFTAASFNG-ESIRPWFWLGMNAQ-LFLMDS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------T-GPG-KFVQASVGEDAVFSCSLFPETSAEAM-EVRFFRNQL-H---A-VVH
LYRHGEDWESM----QMPQYRGRTEL-VKDSIAGGHV-SLRLKNITPLDMGLYGCW--FS
SQ----MYDEEA-TWE------L--Q-VS-----ALGSLP-----------------LI-
------SVVGYVDG-GI-Q---L--LCLSSGWFPQPTVKWKGPQG-QHLSSDS-------
---------------------------R-ANADGHSLYDVETSIIVQ-----E--N-AG-
SILC-SIHLAE-QSH-EVESK-------VLIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-VSVLLGLLC---GGLCVAVMGM--
-----TIVFFKSKGN---L-----------------------------------------
------------------------------------------QWE---GRPL--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------I--PAQISSSVTHVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QK-V------------PYS--
TKRFT-RKSVV-----------ASQG FQ---AG KHY---WE-VD-V------GQNVGWCV
GVCQDDVD-R--R-KDS-------------------------------------------
---------------VTLSPNHGYWVFGLM--T--------EYLYFTFNPY-F-----IN
---------------------------------LSPRTPPT---RVGVLLDYEGGKISFF
NTNDQSC--I-CTLTCQFEG-F-LRPYIWHEISE-K---KMGTPIFLC-PVS-W------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MRISAFK---------VKWR--------------------------------ELPHG
PDTL-------------------LQVWTEM-ASFS-----G-----SWLCSCLI-----T
FVFLQLPT-------------------------------------------HG-------
--------S-GDASKFHLVPLGGTAKLLCPLTLWPVTVPT-EVKWLRSSQPQ-RSQ-AIH
VFRNGKDWDED----LMPEYKGRTAL-VRDA-QEGSV-ILEIRKVRFEDRGQYRCQ--IQ
-I-G--NLSRED-SVT------L--R-VA-----VLGSDP-----------------YI-
------HVKSYDAG-WI-Y---L--VCRSVGWFPEPWAEWRDPQG-GLLLFLS-------
--------------------------EA-HSLDEAGLFQTAVTCRVR-----D--STLG-
NVSC-TVRNEA-LGQ-EKTAA--------------------------------MLI----
------------------------------------------------------------
-----------------------------------------------------TAPSSGR
V---S-----S---------------------SM-VALAVI-LPV-----LGLLIIVG--
I-----CLIWKQRRSKEKLLYD--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRHELKL-----------KRAAANSGWRRARLHFVAVT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PKRFDFVVSVL-----------GSECFT---AGCHY---WE-VY-V------GDKTKWIL
GVCSESVG-R--K-GK--------------------------------------------
---------------VTASPSNGHWLVRQS----------HENAYEALTSPQT------S
---------------------------------FCLKEPPQ---CVGIFLDYDAGVISFY
NVTDKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLIIC-SEL-QKLEEPT
VPKP---------------------------------------------------EGKG-
-QANGDVSLRVDPS---LHPPQGLEL--FPHS---DMILSWPSELGPALQGLKAPYF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MKMA-----S--SSGSS
LSRC-FITLVF------LQLP--------------------------------LRV----
------------------------------------------------------------
-----------------------------------------------------SAPSPGR
F---S-----S---------------------SA-VALAVI-LPV-----LGIFIMVG--
I-----YIIWKQRRSKERLLYE--HAMEVE-NLLSDHAKEK-GR----------------
---------------------------------LY-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRHELKL-----------KRAAANSGWRRARLHFVTVT---L--D-PDTAH
PKLI----------LS-----EDRRCVKLGDT----R--QP-V------------PNN--
PQRFDFVVSVL-----------GSEYFI---AGCHY---WE-VS-V------ADKSKWAL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQN----------RKNEYEALTSPQT------S
---------------------------------FRLKESPR---CVGIFLDYEA-VISFY
NVTN-QH--IFTFTHSF--S-GLFRPFFEL-LHDGG---K--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------MGGR-------
-------------------------KEEPPRIILCVSEEKRRRRG-------------LC
----SLPVL-----------GDSSWALMQPA------ASLP--------ASLLFF-----
-SALSLCA-------------------------------------------QVSAQ-FTV
--------V-GPT-DPILAMLGENITLSCHLLPEKSAEDM-EVRWIRSQF-S---P-AVL
VYKGGRERPEE----QMEEYRGRTTF-VSEDIGRGSV-ALVIHNLTAREDGIYRCY--FQ
-E-G--RSYDEA-TVR------L--L-VA-----GLGSQP-----------------VV-
------EMKDHEDG-GV-L---L--ECRSEGWFPEPRAVWRGPYG-EVVPALA-------
--------------------------EA-YMLDADGLFTVTSTVVVR-----D--GSVR-
NMSC-SVNNTL-LSQ-EKETV-------VFIP-ESFTP-------GISAWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T-LPVLILL-----VAG--S
I-----CLIRKLHREKEI-LSV--------EKEIEREEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LS-----ADGRSVRR--GPFR----QS-V------------PDN--
PERFSCRPCVL-----------GRESFA---SGRHY---WE-VE-V------ENVMVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLLPQNGFWTLEMF-----------GNQYRALGSPDK------T
---------------------------------LPLRERLR---RVAVFLDCEAGDVSFY
NMRDRSH--IYTCPPAAF-G-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGARGLA
VPE--------GGLILHRAGTHQPPQHQFPGLCAI-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVGSPGYY-----A---------GFLLPV----
-LLLQVST---WYS--------------------------------------TVSG-FSV
--------N-GPV-EPTVVLLGTDATLPCQLSPEQSATHM-DIRWYRAQL-S---P-AVL
VYQNGQEQSGE----QMLEYRGRTEL-VKDSISKGGV-ALLIQHVRASDHGQYRCH--FK
-D-G--HSSQEA-VVE------L--H-VI-----GLGSVP-----------------HV-
------HMMGPEDG-GI-R---V--LCSAEGWFPKPRVQWSDMMG-VKLQS-L-------
------T-------------------ES-HTQDEDGLFHVEASLVVT-----D--SSLG-
NVTC-SIQNPL-SGQ-EKVSA-------IFLP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPRM--S----------------P----WKA-ALVGT-VPM-----LVLLLTGM--
S-----YIGWREHQAKEREVK--------KRKKESQE-RDQMENEKELA-LKVS------
------------LA-----QQL----------SEIY--N----VG---------------
------------------------------------------------------------
------------------------------------------------------------
--------------PS-LP------FSLPS-------------ATVT---V--N-QEIFH
QNNS----------DP-----ERK------ENFK--EETHD-L------------SLRDK
--QGDCNLITL-----------NQEDFT---SGKHY---WE-VD-VKDAD------EWTL
GIYENPTD-S--R-EL--------------------------------------------
---------------SKDLQNKKFRVLE-K--K--------GCEYRALTYCLQNISLQEC
---------------------------------LLIKKCPQ---KIVIFLDYEDNDISFY
DMIEGTH--IFSFTQASF-S-GSLYPYFNLKSMK-L-------SL---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MSWQSKGR----------------DYGGPHFCGKVMDFS
---V-------------------SL-NYQRG-------RLPSS------LFFLTHLLL--
--LLQPRV------------------------------------------LC-SEE-IRV
--------V-GHE-EPILAHVGDEVEFSCHLSPYRDAEHM-EILWFQSQA-S---N-VVH
LYREQQEFYGW----QMKQFQNRTQL-ITDDIADGSV-TLRLHRVVPADQGLYGCR--FL
-S-S--DFTGEA-TWE------L--E-VA-----GLGSDP-----------------HI-
------SIEGFKEG-GI-Q---L--RCHSSGWYPKPQAQWRDHHG-RCLPP-E-------
------T-------------------EN-ITEDVQGLFSLETSVVVQ-----E--GAHS-
NVSC-SIQNHL-LGQ-KKEFV-------IHIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGT--S----------------P----WKR-AFLGT-LVG-LPLLLALLMMLV--
L-----YFFRKQRKSQEKLKK--------QAEK-D-K---G-KLTAE---L---------
-----------------GKLQVEL----DWRRAEGQ-----AEWR---AAQRHA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PGSAH
PSLE----------VS-----EDGKSVFSR---RTAL--GS---------------EN--
PQWFSEQTCVL-----------SRERFS---AGRHY---WE-VH-V------GRRSSWFL
GVCLAAVP-S--A-GH--------------------------------------------
---------------ARMSPATGYWVMGLW--N--------SCEYFVLDQH-R------V
--------------------------------PLSVRVPPR---CVGIFLDVEAGKLSFF
NVSDGSH--IFTFTDTF--S-GMLCAYFRPRAHDGS---EHPDPLTIC-PLP-VGEKRVL
EEE------DSDAWLQ----------------------------PY-ESS----------
-----NPALG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---S---------------------------------SSLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAKGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-R---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSAK-
NVSC-YIQNLL-LGQ-EKEVE-------ISIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-PVAVI-MMV-----LGLLTIGS--
I-----FFTWRVYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRETFT---SGRHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---RVGIFLDYESGDISFY
NMNDGSD--IYTFSNV-------------------------------------------T
VIAN----A------------------------QD--------LSKEIPLS---PMGEDS
APRDADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------VFSTI--CL
CLQHSHSP---LLS---------------------------------------TDE-FLV
--------I-GPR-DPIVAVLGEETILPCFLSQAENAENM-ELRWLCSRF-L---E-AVF
IYQNQ--QKEE----EMPQYARWASP-VSVFLTRGEA-AVHIDKVQVSDDGLYTCS--FK
-K-G--DYYEEA-TLE------V--K-VA-----VVGCGP-----------------QV-
------LMEGQEED-GV-H---V--ACRASGWFPKPQVQWRDRS--EKLLT-S-------
------S-------------------EA-HAQDADGLFRLEASVVVR-----D--SSVG-
NVTC-SILNPI-LGQ-EKVKA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPQA--S----------------S----WKP-AFAVS-LMV-----LVVLIFGA--
G-----YFLKKEYLTQVQALK--------ARGCLSDQ-REKVYKA---A-LNTG------
------------RIGLLEAVETQNS-----SVIVCF--L--SARR---KAQLNV------
------------------------------------------------------------
------------------------------------------------------------
--------------VW-QK------KQLKAW-------------SVT---L--D-PRSAC
SNLV----------IS-----QEKTSLTLKDGCV--Y-----------------------
--GNNNTCSVL-----------GREGIT---SGRCY---RE-VE-VGNEE-RG---IWAL
GICREDAN-R--S-YG--------------------------------------------
---------------IIKSPENGFWVME-R--W--------MDKFYACTTTRL-------
--------------------------------------SP----QSGGFLDYDNGYVSFY
NLTDGSH--IFSYLSISF-T-GTLFPYFMLMSGN-M-------SLTIC-S----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPE-KPVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQF-S---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRI-SLRLENITVLDAGLYGCR--IS
SQ----SYYQKA-IWE------L--Q-VS-----ALGSVP-----------------LI-
------SIAGYVDR-DI-Q---L--LCQSSGWFPRPTAKWKGPQG-QDLSTDS-------
---------------------------R-TNRDMHGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSQ-EVESR-------VQIG-DTFFEP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----QIFFSKFQGK----IQ--------AEL----------------------------
------------------------------------------DWR---RKHG--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QAELRDARKHAVEVT---L--D-PETAH
PQLC----------VS-----N-LKTVTERKA----P--QD-V------------PHS--
EKRFT-RKSVV-----------ASQ SFQ---AG KHY---WE-VD-G------GHNKRWRV
GVCRDDVD-R--R-KEY-------------------------------------------
---------------VTLSPDHGYWVLRLN--G--------EHLYFTLNPR-F-----IS
---------------------------------VFPRTPPT---KIGVFLDYECGTISFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPSYN-E---QNGTPIVIC-PVT-QESEKEA
SWQR---------------------------------------------------ASTIP
ETSNSESSSQATTP---FLPRGDV------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSF-----G-----SQ----LI-----T
LIFLQLQL-------------------------------------------PAGLS-G--
--------M-GDASTFHPVPLGGTANLLCPVSLWPGMVPE-EVRWLRSPPPQ-SSQ-VVH
VFRDGKEWDED----LMPEYKGRTAL-VRDT-QEGSV-TLRIYSVSLEDRGAFRCL--VR
-I-G--NQSRED-TVT--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSPGR
V---S-----S---------------------LE-VVLTGI-LFV-----LLLLIVVC--
I-----WLIWKQRKSKEKLLYE--QVMEVE-NLLSEHAKEKVGR----------------
---------------------------------LH-------------KAF---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVVVT---L--D-PDSAH
PKLI----------LS-----KDRKCVRLGDR----R--QP-V------------LDN--
PQRFDFVVSVL-----------GSEYFT---AGCHY---WE-VC-V------GGKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLVRQS----------GENKYEALTSPQI------S
---------------------------------FRLKETPQ---CVGVFLDYEAGVISFY
NVTDKSH--IFTFTDSF--L-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-QQSKELV
APKP---------------------------------------------------EEKF-
-SPNGDVCLKANSS---LLPTPA------PVG---DMLLPFPSDLGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------VS-HFA-----LLDPVLF-----
FLLLSLFA-------------------------------------------QVSAQ-FTV
--------M-GPA-DPVLAMVGESSTLHCHLSPERNAEAM-EVQWYRSQF-Y---P-ALF
MYKSGRERPEE----QIEEYRGRTTF-VSDDISKGCV-ALIRSNITAHKNGFYR-Y--FP
-E-G--KSCNEA-IVH------L--V-VA-----GLGSKP-----------------LV-
------EMKGHEDW-DI-R---L--ECTSAGWYPEPHAVWKDPDG-KIVPALE-------
--------------------------EA-YTAGADGLFTVTLAVIIR-----D--YSVR-
NMSC-SVSNTL-LSQ-SKETG-------IFIP-DALFP----------------------
------------------------------------------------------------
------------------------------------------------------------
------RV--S----------------P----XXX-XXXXX-XXL---K-L---------
Q-----C-GGKQ--------SR--------EKETEHEEKEKEQKELG-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KEKER--Q-----------------------------------------
----IKE-QLQEELRW--------------------RRTLLHAADVV---L--D-PDTAH
PELY----------LS-----KDRRSVIR--GPSR----QN-V------------PDN--
PERFDCRPCVL-----------GGESFT---SGRHY---WE-VE-V------ENVRVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWILELF-----------GNKYRALSSPKI------V
---------------------------------IALKERLC---QVGVFLDYEAGDISFY
NMKNRSH--IYTCPRSPF-S-RPDPSPQPVGPVPGS-------QSHVY-PSP-SPLQHSA
PPP--------GTP----------------------------------------------
-----------------FT---PTS--GSPLLPLIRMLL---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGWSLSSA---LASSFFIL
LTLNWPDDFKVIGPAYP-ILAKVGEDALLTCQLLPKMALRHMEVRWYRLEPCTSV-SVYQ
DGAEVTEMQMEEYRGRVEWKEV-NIADGSVVLKINNIQPSDNGQYWCRFQEEYHHAETSL
QLN VAALGSA PDIHME---------GT---VD---------------------------S
GVELVCTAKGWF----------PKPE---VY---WKNARGENI-----------------
-PTLLEHHIQGED--------------------------------G------------LF
YVESMLVVRDSA----------------------------------TEILSCVIHS----
PILGEE KW------------------------------STI--SIPEK-LQTELAS-LRV
--------I-GPS-QPILARV GEDIQLTCYLSPKTNAQNM-EVRWIRAHR-S---P-AVC
VYMEGEQVIAE----QMEEYRGRTVL-LTDAIDEGRL-TLQISRVRTSDNGLYWCL--FE
-K---DGVYQET-SLD------L--K-VA-----GLGSSP-----------------LI-
------AMKGWKEG-EM-Q---L--MCSSDGWFPPPHVQWRDRQG-RPMPSFS-------
--------------------------EV-LTQDSRGLFHVDTALLVR-----N--RSIV-
NVTC-SLSNPL-LSQ-EKTAA-------YTLS-GY-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------TT-PPGS-TCVCVC----VAT---AKT--AQ
LPT-S----------------------------------------------QGKAD-FKV
--------L-GPD-GPILATLGEDALLPCRLSLNFSAEDM-ELRWYRSRP-S---P-AVY
LHRRGAQVSRE----QMAEYRGRTTF-LGDHLARGKA-VLRIHNITVYDNGTYHCL--FR
-D-G--EPHSET-TLA------L--Q-VA-----GLGLEP-----------------RI-
------HVTEDLDK-GI-R---A--ECTSAGWYPEPHVEWRDFRG-HAVPA-V-------
------T-------------------RF-SASATTGLLAVLSRVAVP-----D--RSMG-
GLTC-SISSPL-LHE-RKVA----E---SHLP-R--------------------------
------------------------------------------------------------
------------------------------------------------------------
------QP--P----------------P--SAWRM-PLFLI-LIV-----LGLITAGG--
L-----CLCPKLNRKESEEQP--------EKAKSKES-----------------------
---M--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LS-----EHR-K-------------------STGVPRVSPS---L--D-PATAS
PKLS----------LS-----EDQKSVRRLLF----D--QD-L------------PPS--
ASRFDQDPCVL-----------AQEQFF---TGQYY---WE-VE-V------GDRKAWTL
GVCLGSVG-R--E-GR--------------------------------------------
---------------VPKAPQHGLWAVE-F--Y--------KERLQALSYP-R-----TQ
---------------------------------LRPPQHLC---RVGVFLDCDRGKISFH
NAADGSL--VYAFSGLSF-S-GPLQPFLCLWTHDPS-------PLTFC-P----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------KPPVVTVGGHADLTCQLSPPQSAEHM-NVGWYRDHY-S---Q-PIY
VHKDGGKLSGK----SPPNYMNRTMF-LNNNLREGKM-TLRIHSINVFDEGQYHCF--FK
-D-G--DIYEEA-IVD------L--K-VA-----ALGLDI-----------------QI-
------NVQVFNTK-EI-M---V--ECNSQGWFPQAQMKWRDSRG-NVIPP-L-------
------S-------------------KI-FSQDEAGLLHLKTSVLLK-----N--NTHG-
PVTC-GFYNPV-TGQ-EKRAG-------IVLP-GECS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALHFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLRCHLSPEKNAEDM-EVRWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------EMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-RVVPALK-------
--------------------------EV-VTPDTDGLFMVTTAVIIR-----D--KSMR-
NMSC-SINDTL-LDQ-KKESV-------IFIP-ESFMP-------SMSPCVVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVFLMII-----IAV--C
I-----YWINRLQKETKI-LSG--------EKEFELETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEK----ER----------------------------------------
-KT---REIAVKELEK--------------------ERVTSSAVDVV---L--D-PDTAH
PDLL----------LS-----EDRRSVRR--CPLR-HLGES-V------------PDN--
PERFDSEPCVL-----------GRESFA---SGKHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-EE--------------------------------------------
---------------VLLLPQNGFWTLEMC-----------KGQYRALSSPKR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-MPVRPFFRIGSDDSP-------I-FIC-PAL-TGANGVT
VPE--------EGLTFHRVRTNQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
FFLVQ-------------------------------------------LLPPCSAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTLI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPKIQWSNAKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSETDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------HAE--MV
FAQLSIV-------------------------------------------LLPTGQ-WEV
--------I-GPD-KPIQASAGEDVIFTCFLTPETSAAAM-EVRFFRNHF-S---A--VH
FYSNGKELEHM----QMRLSR-------ENSIVNGRV-SLRLKKITPLDAGLYGCS--FS
FQ----TYYQEA-VWE------L--Q-VS-----ALGSTP-----------------LV-
------SIMGYAYG-EI-Q---L--CCQSSGWFPQPMVKWKRPQG-HDLPSDS-------
---------------------------K-VNVDKQGLFDVETYLTIQ-----E--N-SG-
SISC-SIQIVE-QSQ-SVESR-------VWIG-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRM-ASILLGFFF---FGLCVCIIGQ--
-----FIFLFKCQRK----LQ--------EEL----------------------------
------------------------------------------NWR---RKQE--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------QTEWRDAQKHKVELT---L--D-PDSAH
PQLC----------IS-----N-LREVTYVDV----P--QE-V------------PDS--
EKRFI-RMCVV-----------ASQGFS---AGKHY---WE-VY-V------GKKEGWCL
GVCLDEVD-R--K-MQF-------------------------------------------
---------------VTLSPNNGYWILGHS--A--------QDQYFSYNPH-G-----FY
---------------------------------LSPRTPPT---QVGIFLDYEGGTISFF
NINDQSL--IY-TLTHPFKG-L-LRPYIQYWPCS-R---ENLGKIVIC-PMS--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------SGLP---------RCL-----LT
LILLQLPK------------------------------------------LDS-AP-FDV
--------I-GPP-EPILAVVGEDAELPCRLSPNASAEHL-ELRWFRKKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VQDGIAEGRV-ALRIRGVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVH------L--K-VA-----ALGSDP-----------------HI-
------SMQVQENG-EI-W---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQN LL-LGQ-EKEVE-------IFIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTIGS--
I-----FFTWRLYNERSRERR--------NEFSSK-------------------------
-------------------------------ERLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVD VT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QK-L------------PEK--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCKENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAGPPR---QVGIFLDYESGDISFY
NMNDGSH--IYTFSNISF-S-GPLRPFFCLWSCG-------KKPLTIC-PIA-DGPEGVT
VIAN----A------------------------QD--------LSKEIPLS---PIGEDC
ASADADT---LHSK---LIPTQPSQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MKGLSLS
---HS---------------------------SRAS-SSLP-A-----------FI--LF
FITFYVHK-------------------------------------------LESAR-FTV
--------A-GPG-HPVPAVVGEDIVLPCHLSPSVSAEHM-EVRWFRHEF-A---S-FVH
LYQHGKDQFGQ----QMPEYHGRTEL-FKADIAGGNV-ALKIANVRPSDEGQYHCF--VQ
-E-G--VSYEEA-VLQ------L--E-VA-----ASGSAP-----------------QI-
------SVEGYQDG-GI-R---M--VCHLAGWYPEPEVLWRDLSG-QRLSS-S-------
------A-------------------ET-KSRDAQGLFEIRSSLVVT-----E--RSNQ-
NVSC-SIRSTR-FSL-EKDPS---T---FYMS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------F
F---FPRT--S----------------P----WLV-VWSVT-LVI-----LLVFIGLT--
L-----FLFRLR----GNLNS--------S------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKPV-------SLTSS------LVLFMHLLL--
---LRPGE------------------------------------------PN-PEK-ITV
--------V-GPA-DPILALVGEEVEFSCHLWPYLDAQHM-EIRWFRSHT-S---N-VVH
LYWEQQELLGR----QMEAFRNRTKL-VKDDITDGSV-ALQLHSIIPSDEGMYGCR--FL
-S-D--NFSGEA-IWE------L--E-VA-----GQGSEP-----------------HF-
------SLEGSKEG-GI-Q---L--RLRSSGWYPKPNAQWRNHQG-QCLPP-E-------
------F-------------------EA-IVQDSQGLFSLETSVIVR-----E--GALS-
NVTL-SIQNLL-LSQ-KKEYV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGG--S----------------R----WKS-AFVGT-MAV-LPPLLAVLVALA--
L-----GLLQKQRRRQEKLKK--------QAEK-RQG---KLTVELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---AAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTSAH
PSLE----------VS-----EDGKSVFSR---GAPP--SP-A------------LSD--
PQGFSEQKCVL-----------SLQR FS---AG RHY---WE-VQ-V------GCSSRWLL
GACLAAVP-R--S-RP--------------------------------------------
---------------MRLSPAAGYWVLGLW--N--------GCEYFVLAPR-R------V
--------------------------------ALTLRVPPR---RVGVFLDYQAGKLSFF
NVSDGSH--IFTFHDTF--S-GALCAYFRPRAHDGG---EHPDPLTIC-PLP-LKGTCVP
EEN------DSDTWLQ----------------------------PY-EPA----------
-----DSSLD-------PW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------LG-------------------------------------------HSTAQ-FTL
--------V-GPD-RPVTAVVGEDIMLPCHLAPRMSAENM-EMTWFRSKL-F---P-FVH
RYSDGKDQYGE----QMPEYQRRTQL-LKGGLTQGNV-TLKILHVRVSDEGRYSCF--VQ
-D-G--NSFEEA-ILE------L--Q-VS-----ASGSAP-----------------HL-
------SIEDYQDG-GI-R---V--VCRSPGWYPEPEVIWRDLSG-QAFPS-A-------
------S-------------------HT-NSREANGLYETQTSAIIM-----E--NSSR-
NLSC-LVRNTR-LSQ-KKEST---L-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFHVS
LFLLLTPC-------------------------SGRERFHDSTFI---LPLVPTAQ-FSV
--------L-GPS-GPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPKIQWSNAKG-QNIPAV--------
--------------------------EAPLVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LGL-EKTAS-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-ALQTP-SSL-----FLRTRGVC--
S-----V--PRSPRICQTTLRDLIGIIVFSAVRASSYITPTVICAVG-------------
----------------RWSA---------SVSG---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------HLPIL---F--H-PDSSP
M-----------------------------GK----T--HL-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMKPE--FS---HFF--------GFC------VY
FLFLQ--V------------------------------------------MASSEK-LRV
--------T-TPT-RHLLARVGGQAELSCQVIPPHSVMHM-EVRWFRSGH-S---Q-PVY
LYRGGHKMSEE----AAPEYANRTEF-VKEAIGEGKV-SLRIYNINILDDGPYQCS--FN
-D-S--GFIDVA-IMN------L--N-VT-----AVGLET-----------------EI-
------HVQAPDAD-GV-M---V--ECNTGGWFPRPQMEWRDSKG-ATLPH-S-------
------L-------------------KS-YSQDEARFFHMKMTLLLT-----N--MSHG-
SIIC-CISNPV-TGE-EKQTS-------IILA-NELFN-------QDYLWVGIFPFSVLS
L-ILFGVLPFINSFFRSQGCAS-----------------------------------GCL
SKCLPVVTSWPVQIVH--FL---VCSGVLFAVYLPHR---------------YRVSLSDP
Q---FPLY--N--------------------NWI-TELLI-VILF-LTI-CFVLPITV--
L-----LLIKLSPTCLAK--W--------EKNKDDIM--------DSQLGL---------
------------------------------G-----------------KARE--------
-----------ASTLYE-----EQSR----------------------------------
-KSWEQEK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------E-FKV
--------I-GPS-DPIIAVVGGDITLPCHVSPPMNVENM-ELRWFRSKF-S---E-AVF
IYQNHREETEE----QMARYTGRTSI---DLLSQGEA-AVRIHKVQAADNGQYTCF--FR
-K-G--NFYEEA-GLE------L--K-VA-----GVGSAP-----------------QV-
------HITGPEED-GV-R---L--VCRAEGWFPKPEVQWRDSSG-GKFLD-F-------
------S-------------------ET-KAQDAEGLFSVEAALVVR-----D--SAVG-
NMTC-SILNPI-LDQ-EKAM----A---IFIP-XXXXXXXXXXXX---------------
------------------------------------------------------------
-------------------------------------------XXXX-----X-XXXXXX
X-------------------------------------------------------XX--
------------XXX-XXXXX---------XXXXXXXXXXXXXX-XXX------------
--------------------X---------------------------------------
---------------X-----XXX---------XXXXXXXX-------------------
-----------------XXXXX-------------------------------------X
XXXXXXXXXXXXXXXX-XX------XXXXXXX-----XXXXXXXNVI---L--D-EVTAH
PTLL----------LS-----DENKPVKNHQ---------D-L------------PSS--
EQRFESLPCVL-----------GQQNIT---LGRCY---WE-VN-V------GDTRSWDL
GICRNDVP-R--K-GR--------------------------------------------
---------------IIVSPQNGFWAIR-L--Y--------DGEYWAITSP-E-------
---------------------------------THLYKTYK---VVGIFLDYEAGDVSFY
DMEDGSH--IFSFPQNTF-R-GALRPFFRLWS-SDS-------GTLTC-S----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVNGPGYSLSGV---AASLLFIL
LTMKHPDDFRVVGPALP-ILAKVGEDALLTCRLLPQRAAAHMEVRWYRSDPDSPV-LVHR
EGAEVAGLQAEGYRGRVEQTEDSAADEGSVALKIRQIQPGDDGQYWCRFQEGDYWREASV
RLQVTALGSSPNIHVE---------GP---GE---------------------------G
EVQLVCTSQGWF----------PEPE---VF---WEGSWGEKL-----------------
-SSFSENHVLGED--------------------------------G------------LF
YVEDTLVVRNDT----------------------------------SETISCSIYN----
RGLKEAKE------------------------------ATI--ALPEK-LQTELAT-SRV
--------I-GPS-RPILVRLGENIELTCHLSPQADAQSM-EVRWVRSHY-Y---S-TVH
VYVDGARSAGE----QMAEYRGRTVV-MSDTIHQGRL-TLRIQDARTSDDGQYRCL--FG
-K---DGVYQEA-LVD------V--Q-VM-----AVGSTP-----------------RI-
------TREVLKNG-GA-Q---L--RCVSEGWFPRPHVQWRDMAG-RAAPSLS-------
--------------------------ET-FHQGSQGLFQVETLLLVT-----N--SSLV-
NVTC-SVSLPG--GE-EKVAH-------LPLS-DSRI-----------------------
------------------------------------------------------------
-----------------------------------------------------------A
L---------L---------------------WMALPVLLL-PLAMA-------------
F-----DLIKEKHSSKGKWVD--------R-AGQ--------------------------
--------------------------------------A--LGHF---FSS---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-EVRWFRSEI-T---P-FVH
LYQHKQDEYVQ----QMPEYRGRTKL-LKASITEGIV-DLRIINVRHSDKGLYRCS--VQ
-D-G--DFHEES-VLE------L--E-VA-----ALGSAP-----------------RI-
------SVEGHQDG-GI-R---V--VCQSAGWYPQPQVLWRDPKG-QPLSA-S-------
------T-------------------ET-KSEEEGGFFQIKNSIVVT-----E--NSNK-
NLSC--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGST--GL---YFY--------GHC------VV
MFLLQ-MN------------------------------------------TANSEL-FTV
--------T-GSD-VPVLASLGGNLELSCQLSPPQQAQHM-EIRWFRNLY-R---E-PVH
LYRDGKDMFGE----IISKYVERTEL-LKDGIGEGKV-TLRIYNVTVDDDGFYHCV--FK
-E-G--DFYEEH-ITE------V--K-VT-----AINLRV-----------------QI-
------HVHPPNTK-GV-I---V--ECHSGGWFPRPLMEWRDSRG-EVIPA-A-------
------S-------------------KS-HSQGGDRLFNMKISLLIS-----D--SSFQ-
KITC-CLQNPL-TGQ-EGRTS-------VILS-DAFFS-------WNIIWKMILGIILFV
MVL-SILVSSFLL-HPEHNRCR--------------------------------------
---CTCDAPWVTGILIMISS---VVIVISIMGYLHLK---------------QRVPVSDA
H---FELD--I--------------------LWV-EDLSV-ILCS-LMV-SATMLI-S--
Y-----TYFKLRDWC--------------HKIILRGT--------SSATDGNRC-K----
-----------------E--P-HL------N-----------------IK----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------DIPLLVLLVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------I-GPP-EPILAMVGEDVDLSCHVSPKMSAESM-ELLWVRPNL-R---E-VVY
EYANGKEIEDQ----QMAEYRGRTSI-LRDGITEGTS-TLRIYNVRPSDTGNYLCY--FQ
-G-D--NFYEKA-MVE------L--E-VA-----ELGSDP-----------------HI-
------EMKGYEGG-GI-H---L--ECMSTGWYPQPQIQWRDAKG-EVMPAV--------
--------------------------AAPLVEDGDGLYAVTASVIVK-----G--SSGE-
GVSC-LIRNPL-LNQ-EKTTG-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FWRA--Q----------------P----WIA-AFAGT-LPV-----LLLLLAGA--
V-----YFLWRQKKEKEAL---------SQEKEALSQEIEALFQETKAL-----------
---------------FQEKER--------KKKLLQE-F---NRWI---PVHIY-------
------------------------------------------------------------
------------------------------------------------------------
----SHIEKSQ--------------------AYAEWKTALFQPADVI---L--D-PDTAN
HILL----------IS-----EDRKILKLADS----E--QN-L------------PDN--
PKRFNTRNSVL-----------GCKSFM---SGRHF---WE-VD-V------GVRKGWYV
GVCRENVE-R---KKQ--------------------------------------------
---------------VSMAPKNGFWIIGLS--D--------MNEYQALTDP-L-----TK
---------------------------------LEILNPPQ---KVGIFLDYETGEISFY
NAKDGSH--IYTFPHTSF-S-GPLYPIFRLLGWDDT-------PLTIF-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------IGPARAADEGDYRCL--FR
-D-NA--SSGEA-IVR------L--R-VA-----ALGSDP-----------------HI-
------GMEVQENG-EI-R---L--ECTSVGWYPEPQVQWTTRAG-EKFLS-T-------
------F-------------------ES-RSPDQEGLFTVAASVIIR-----D--TSLE-
NVSC-CIHNL L-LGQ-QKEVG-------ISIS-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WQV-AVAVI-LTV-----LGLLTIGS--
I-----VFIWRLYKDRFRERK--------SEFSSK-------------------------
-------------------------------EKLLE-EF---KLK---KASLHA------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VD VT---L--D-PDTAH
PHLF----------LY-----ADSKSVRLEDS----R--QK-L------------PEK--
AERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWVV
GVCKEDVI-K--K-GF--------------------------------------------
---------------DPLTPENGFWAVELY-----------GNGYWALTQV-R-----TP
---------------------------------LSLAGPLH---RVGIFLDYDSGDISFF
NMTNGSH--IYTFSSISF-S-GPLRPFFCLWSCG-------KKPLTIC-SVA-DGPEEVK
VVAD----A------------------------QA--------LSKDIPLS---PLGEES
ASGDADT---LHYK---LIPLQISQG--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------YKLR-KYYN-ILFLSC------SKSAFFI--LS
ISLCGYS------------------------------------------------V-FHV
--------I-GPR-KPVIALVGGEVVLPCHLSPSMDAEDM-EVKWHKTHL-S---G-AVH
YYENFQDNLQK----QRPEYQGRTEF-LKDNITKGQV-ALRIHPVLPSDEGEYSCS--FL
-S-S--THNDAA-RFN------V--L-AT-----ASGISP-----------------HI-
------YIEPNISR-GI-Q---L--TCTSMDWYPEPEVQWRGQQG-QLLPP-H-------
------T-------------------ER-MTIEENGLVFKETSITVD-----G--SSAG-
SISC-FIMNPV-LNV-EKGA----Y---MSIT-H--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L---FPKV--S----------------P----WTV-GLSVLVGLL-----VLTLMIIS--
V-----LLCWTRKDRGKKE----------RKKERK-------KERKKERL---RK-----
--------T-EEEVGIKTSLNSN------ITST---------------KI---------T
RF----------------------------------------------------------
--------------IRVEEKSS--------------------------------------
--------LSMKFHLY-NL-------------------ISSSTADII---L--D-KTTAH
PILY----------VT-----NNRKSVIFLSK----E--QD-V------------PDN--
PERFDTMPAVL-----------GHNSFS---DGQHY---WE-VD-V--TG----KTSWEI
GLCLDSVK-R--KGDI--------------------------------------------
----------------LCSPENGFWALC-L--V--------NGAYVALSTP-P-----IC
---------------------------------LYVPTPPS---RVGISLNYEKGLISFY
NLTKLSI--LYTFKS-KF-T-QPLKPYFYIGHLIP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------SAQ-FTV
--------I-GPA-GPIVALLGKEITLPCDLYPLKNVEHV-DIKWYRKRF-L---P-G--
-----ECLLEF----IMIRKRTSSFL-FLFSQFNQHL-LICCTQKMLWEPKINHCL--VL
YL-S--LLYLYM-LLC------L--S-FP-----AWGSDP-----------------QI-
------HVKPLKDG-EI-L---L--LCQSNGWYPKPQVGWKDIQG-ENLPS-L-------
------S-------------------ES-QSQDGEDLFQTETSLVVQ-----S--NSTE-
DVFC-FLQHPL-LEE-QKIV----K---PPPR-V--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FLRK--C----------------V----WVV-AFAAA-FLI-----VGLFILGC--
I-----YCIWKRRCAKDLLIN--------EKASR--Q-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SHSEFW-RVVSR-LQ---------RFIVVSLFIVDVI---L--D-PATAH
PILI----------VS-----EDQSQVTHGDA----E--QD-V------------PKT--
NQRFDSRPCVM-----------GSKGFT---SGRYY---WE-VE-V--GT----GASWTL
GVCREAVS-K--K-GW--------------------------------------------
---------------LALSPEEGFWTMR-L--Q--------KNHYEALSSP-V-----TP
---------------------------------LSLTTSFS---RVGVYLDCEVKEVSFY
NVTDRSH--IYTFPNCSF-S-GAIYPFFWVSPGA---------PLIL-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEMT--G---------QSFSRYF--------VA
TLLLQ-MI------------------------------------------TPSSEQ-FTV
--------N-GIE-GPILAPLGGKVELSCQLSPPQTAEHM-EIRWFRNHY-K---R-PVH
LYKDGKDLYGE----TISNYVERTEL-LTDAIGEGKV-TLRIFSVNADDDGTYHCF--FK
-D-G--DFYEEA-ITE------V--K-VT-----ATSLET-----------------QI-
------LVHPPNTK-GL-L---V--ECNSGGWFPQPQMEWRDSRE-EIIPP-S-------
------S-------------------KS-HSQDTDKLFNMKMTLLIQ-----S--TH-G-
NVTC-YLRNPV-TGQ-EEKIS-------IVLS-NKPFL-------WNTVWKLILGLILAL
PLT-FTMASSIAL-HHRLQSCS--------------------------------------
---CNALPPWLVGILIFLTS---FSMIVSLIFYLHYR---------------KRVPISDP
H---FELD--V--------------------MWL-EDMTV-ILCV-LMV-FITMII-S--
S-----AYFRLRVKL--------------HVH----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPN-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQR-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRL-SLRLENITALDAGLYGCR--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWLPRPIAKWKGPQG-QDLSADS-------
---------------------------R-TNTNMHGLFDVELSLTVQ-----E--N-AG-
SVSC-SMQHAH-LSQ-EVESR-------VQIG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MLMEPV------ASLYFS-----LPGFLLF-----
FHLLSSFA-------------------------------------------PVSVQ-FNV
--------L-GPA-YPVLAVVGENVMLRCHLSPEKNAEDM-EVRWFRAQF-S---P-AVF
VYKGRRERTDE----QMEQYRGRTTF-VSEAISKGSV-GLIIHNVTAHENGFYCCY--FQ
-E-G--RSYDEA-IVH------L--I-VI-----SLGSKP-----------------VI-
------EMKGLEDG-GI-R---L--ECVSAGWYPKPQAVWRDPHG-EIMPPLE-------
--------------------------ES-YTVSADGLFLVTTAVIIR-----D--HSVR-
NMSC-SVSNTL-LNQ-EKETV-------IFIP-ESFIP----------------------
------------------------------------------------------------
------------------------------------------------------------
------RT--S----------------P----WMV-ALAVI-LPTL--PLL---IAG--S
I-----YLIKKLQLGKKI-LSM--------QKEADNEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----ITQQLQEELRW--------------------RRSLLHAADVV---L--D-PDTAH
PELF----------LS-----EDQRSVRR--GPSR----QS-V------------PDN--
PERFDCRPCVL-----------GLE SYS---LG RHF---WE-VD-V------ENVMVWAV
GVCRDNVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------ENQYRALSSPEK------I
---------------------------------LPLKERLH---RVGVFLDCEAGDVSFY
NMKDRSH--IYTCPRSPF-S-GPLRPFFRLGSDDSP-------L-YIC-PSF-RGAQGVT
VPE--------GGLVLY--RAETHHNHQF----PG--------LRAR-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVFP
---N---------------------------------CDFP---------RCL-----LT
LILLQLPQ------------------------------------------LDS-VP-FDV
--------I-GPL-QPILAVVGEDAELPCRLSPNASAESL-EVRWFRRKV-S---P-AVL
VHRDGREQEAE----QMPEYRGRATL-VRDGIAEGRV-ALRIRSVRVSDDGEYTCF--FR
-E-DG--SYEEA-LVR------L--K-VA-----ALGSDP-----------------HI-
------TMQVQENG-EI-Q---L--ECTSVGWYPEPQVQWRTSKG-EKFPS-T-------
------S-------------------ES-RNPDEEGLFTVAASVIIR-----D--TSVK-
NVSC-YIQNLL-LGQ-EKEVE-------VSIP-ASS------------------------
------------------------------------------------------------
------------------------------------------------------------
----LPR-L-T----------------P----WIV-AVAVI-LMV-----LGLLTTGS--
I-----FFTWRLYKERSREKK--------NEFSCK-------------------------
-------------------------------EKLLE-EL---KWK---KATLH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------AVDVT---L--D-PDTAH
PHLF----------IY-----EDSKSVRLEDS----H--QK-L------------PEK--
PERFDSWPCVL-----------GREA FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVM-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GSGYWALTPL-R-----TP
---------------------------------LPLAGSPR---RVGIFLDYESGDVSFY
SMNDGSH--IYTFDNVSF-S-GPLRPFFCLWSCG-------KKPLTIC-PVA-DGPEGVT
VIAN----A------------------------PD--------LSKEILLS---PIGEDS
TSGDADT---LHSK---LIPTQPSQG--AS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MENM--A-GCP-----ESF-----TSRFLV----IL
-LFLQLLT-------------------------------------------MGSAQ-FSV
--------I-GPA-EPVLALEGGDTEMPCHLNPKESAEFM-EVRWFRSRP-S---N-IVH
LYDNREELFRE----QMEEYQGRTEL-VRDAMDYGSV-AVRLLNVRVSDEGNYHCS--FY
-D-G--NTVDRA-PLE------L--Q-VV-----VLETDINT----------------L-
------GFEGGESG-GV-AHLEL--EFQCSPCSPN---HW--------------------
--VPSPTPPPSLQRQEGRPGVSAPALGS-Q-HVLNALYAPQTT---------G--SRGR-
AHNI-PFRDSM-FSL-DDIF----G---NFIS-A--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
L---FPTA--L----------------S----LMV-ALGVT-LPV-----LGLIIAGG--
L-----YLIWKQNMDIGKGRK--------TQPTLCLCQLSFMGV-GRQYSFSEK------
--LLVKLSWGLCPG-HQARDI----------SSLSS--L--AGWS---RAQL--------
------------------------HQT---------------------------------
------------------------------------------------------------
--------------------------------------------NVT---L--D-PHTAH
PQLV----------LS-----EDRKRVSLGDT----R--HG-L------------PAN--
PERFSDNWCVL-----------GRERFT---SGRHC---WE-VE-V------GEKRSWYL
GVCRENMR-R--K-VG--------------------------------------------
---------------ISESPAGGLWAVK-R--D--------NGEYWAITSP-R-----VP
---------------------------------LPLTTPPS---RVVVYLDYEAGDVSFY
SGTDGSH--IYTFPRAAF-S-GALRPFFYLWSYDSV-------PLIIC-PVP-DGAGGDP
VP----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--VL
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------T-GPG-KFLQASVGEDAVFSCSLFPETSAEAM-EVRFFRNQL-H---A-VVH
LYRDGEDWESM----QMPQYRGRTEL-VKDSIAGGHV-SLRLKNITLLDMGLYGCW--FS
SQ----IYDEEA-TWE------L--Q-VS-----ALGSLP-----------------LI-
------SIVGYVDG-GI-Q---L--LCLSSGWFPQPTVKWKGPQG-QHLSSDS-------
---------------------------R-VNADGHSLYDVETSIIVQ-----E--N-AG-
SISC-SIHLAE-QSH-EVQSK-------VLIG----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------VEVT---L--D-PETAH
PQLC----------VS-----D-LKTVTHRKA----P--QD-M------------PPS--
EKRFI-RMSVV-----------A SQNFQ---AG RHY---WE-VD-V------GHNQRWYV
GVCQDGVN-R--R-KKR-------------------------------------------
---------------VTLSPNHGYWVLGMS--A--------KNSYFTLNPH-F-----IS
---------------------------------LCPRTPLT---QIGVFLDYECGTVSFF
NINDQSL--IY-TLTCRFEG-L-LRPYIEYPFHN-E---QNGTPIVIC-PVT-QES----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------KRILKKA--VV---CLI--------SKHIS----VA
FTLKPCSP------------------------------------------TSFTEQ-FTV
--------H-TSR-SLQVVLVGGHTELSCQLSPPESAEHM-QVGWYRDHY-Q-----PIS
VYKKEKKLSGK----STQNYTNHTVL-LKDALGEGKM-TLRIHNVSITDEGKYHCF--FK
-D-G--DISEEA-VVD------L--K-VA-----ALGLDI-----------------QI-
------NVHAPDSK-GL-V---V--ECNSGGWYPQPQMKWRDSRG-NVVPA-S-------
------S-------------------KT-FSEDGAGLLHLKTSVLIK-----N--STHG-
PITC-CFHNPV-TSQ-EKRAS-------I-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------SLDSLKLV-------SLTSS------LVFFMHLLL--
---LQPGE------------------------------------------LN-PEK-VTV
--------V-GPA-DPILALIGEEVEFSCHLWPYLDAQHM-EIRWFRSHT-S---D-VVH
LYREQQELLGR----QMEAFRNRTKL-VKDDIADGSV-ALQLHSIVPSDEGMYGCR--FL
-S-D--NFSGEA-VWE------L--E-VA-----GQGSEP-----------------HL-
------SLEGSKEG-GI-Q---L--KLRSSGWYPKPKAQWRNHQG-QCLPP-E-------
------F-------------------EA-IVQDSQGLFSLETSVIVR-----E--GALS-
NVSL-SIQNLL-LGQ-KKEYV-------VQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGA--S----------------R----WKS-AFVGT-MAM-LPPLLAVLVALA--
L-----GLLQKQRRRQEKLKK--------QAEK-RQG---KLTAELE-------------
------------------KLQTEL----DWRRAEGQ-----AEWR---TAQKYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
RSLE----------VS-----EDCKSVFSR---GAPP--SP-A------------PSD--
RQRFSEQKCVL-----------SLQR FS---AG RHY---WE-VH-V------GCSSRWLL
GACLAAVP-R--S-RP--------------------------------------------
---------------VRLSPAAGYWVLGLW--N--------GCEYFVLAPH-R------V
--------------------------------ALTLRVPPR---RMGVFLDCQAGKLSFF
NVSDGSH--IFTFHDTF--S-GVLCAYFRPRAHDGG---EHADPLTIC-PLP-VKGTCVP
EEN------DSDT-LQ----------------------------PY-EPA----------
-----DSALD-------PW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPD-KAVQALVGEDAAFSCFLSPKTNAEAM-EVRFFRGQL-F---S-VVH
LYRDGKDQPFM----QMPQYQGRTKL-VKDSIAEGRL-SLRLENITALDAGLYGCW--IG
SQ-S--SYYQEA-TWE------L--Q-VS-----ALGSVP-----------------LI-
------SIVGYVDR-GI-Q---L--LCRSSGWFPRPIAKWKGPQG-QDLSADS-------
---------------------------R-TNTNMRGLFDVEISLTVQ-----E--N-AG-
SISC-SMQHAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------I----------------S----WHL-ATKVLGILC---CGLFFGIVGL--
-----KIFFSKFQEA----WA--------GDL----------------------------
------------------------------------------FMV---PAGT--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------GSEML---------------------PH
P-SC----------FS-----S-SSPSLQGPR----P-----------------------
-KKVI-TLL---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAL--ML
SLVLSLL-------------------------------------------KLGSGQ-WQV
--------F-GPG-KPVQALVGEDAVFSCFLSPETNAEAM-EVRFFRGQV-S---S-VVY
LYRKGKDQPSM----QMPQYQARTKL-VKDSIAEGHV-SLRLENITVLDAGLYGCW--IG
SQ----SYHQEA-VWE------L--Q-VS-----ALGSVP-----------------LI-
------SIMAYVDR-GI-Q---L--LCRSSGWFPRPTAKWKGPQG-QELSTDS-------
---------------------------R-TNTDMHGLFDVEISLTVQ-----E--N-AG-
TISC-SMRPAH-LSQ-EVESR-------VQIG-DTFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------V----------------S----WAL-AVKVLGILC---SGLFFGIVGL--
-----KIFFSKFQEA----WA--------GTL----------------------------
------------------------------------------F-----------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MISSSVTHVT---L--D-PETAH
PQLC----------VS-----Y-LKTVTHRTA----L--QE-V------------PYS--
EKRFT-RKSVV-----------ASQ SFQ---AG KHY---WE-VD-M------GYSTWWYV
GVCRDDVD-R--K-QKY-------------------------------------------
---------------VTLSPNNGYWVLGLK--K--------L--HFTFNPH-L-----IN
---------------------------------LFPRIPPT---RIGIFLDYEGGTISFF
NINDQTL--IY-TLTCRFEG-L-LRPYVEHK----R---NNGTLIVIG-PLS-QESEREA
SSQS---------------------------------------------------AFTTL
EAYNSESSSQLATP---FLPRSD-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKTA------SGL----------AFLLFDFLAC
LILVQ-------------------------------------------LLMPCSAQ-FAV
--------H-GPP-GPILAMVGEDADLPCHLSPMMSAETM-ELRWVRSSL-R---Q-VVT
VYAGGKEVENK----QTPEYRGRTSI-LRGDITAGKA-ALRIHSVKASDSGNYLCY--FQ
-D-G--NFYEKA-IVE------L--K-VA-----ALGADL-----------------HM-
------EMKGYEDG-GI-H---L--ECRSTGWYPQPHVQWRDAKG-EVIPAV--------
--------------------------AAPVVADGAGLYAVAASVIMR-----G--SSGE-
GVSC-TIRNSL-LQQ-EKTAR-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----WIA-TLAGT-LPI-----SLLLLTVA--
S-----YFLWQQQEKKMTL---------LREKEREQEMRELAQSTTE-------------
----------------QERS---------TREMLEE-E---LKWR---KIQYMA------
----------------------RGA-----------------------------------
------------------------------------------------------------
--------KSP--------------------AYNEWKVALFQAADVT---L--D-PDSAN
PILL----------LS-----EDLRSLQRAEE----K--QD-L------------PDI--
PERFNWHHCVL-----------GQES FT---SG RHY---WE-VE-V------GDRQEWHI
GVCRRNVE-R---KGW--------------------------------------------
---------------VKMIPENGFWTMGQS--G--------ENNYRALTEP-R-----TK
---------------------------------LTLAGPPE---RVGVFLDYETGEVSFY
NAIDGSH--IYTFLRTSF-S-GPLCPVFRILTLEPT-------ALTIC-PAP--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------META--GL---SFS--------RCF------VV
MNLLQ-MT------------------------------------------IPSSEQ-FTV
--------N-SLE-RPVLAALGGKVELSCQLSPPQSAEHM-EIRWFRSHY-T---R-PVY
LYKEGKDLYGE----TISKYVERTKL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--DVCEEA-IAE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNTK-GL-L---V--ECNSEGWFPQPQMEWRDSRG-EIIPP-S-------
------S-------------------KS-HSQDRNKLFNMKMSLLLR-----D--SSHG-
NITC-YLRNPV-TGQ-EERAS-------IVLS-DKLFP-------WDSVWILILVAILAV
LLF-FIMMPSVEL-QQREQRR-CCD---------------------------------WN
-------SPCLIGIGIVFSS---VCVITGLTITLHHR---------------NRVPVSDR
K---FQFV--S--------------------MYL-EDMTV-MVWV-LMV-FITMLI-S--
L-----VYFRLRGFF--------------QI-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEST--GL---SFS--------RYF------VV
MNLLQ-MT------------------------------------------ISSSG--RPI
-----------------LAPLGRKVELSCQLSPPQSFRSH---------Y-T---R-PVY
LYKDGKDLYGE----TISKYVERTEL-LKEAIGEGKV-TLRILNVSADDDGQYHCF--FK
-D-G--NVYEEA-ITE------V--K-VT-----ATSLEI-----------------QI-
------LIHPPNSK-GL-L---V--ECNSEGWFPQPQMEWRESRG-EIIPP-A-------
------S-------------------KS-YSQDRNKLFNMKMSLLLR-----D--SSHD-
NITC-YLQNPV-TGQ-EERTS-------IVLP-DKLFP-------WNSIWILILVAILAV
LLF-FIMLPSVEL-QQKEQRNASTP---------------------------------IT
NNYNIS-SSGNWCIGIVFFS---MCVIVGLIIGLHRR---------------NRGMWIKR
M---GTS-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SDL----------TCLLLDFFVC
LVLIQ-------------------------------------------LLTPCSAH-FAV
--------H-GPA-GPILAMVGKDADLPCHLSPTMSAETL-ELRWVRSSL-R---Q-VVN
VYANGKEVEDK----QTPEYRGRTSI-LRDDITAGKA-TLRIHNVTASDSGNYLCY--FQ
-D-G--NFYEKA-MVE------L--K-VA-----ALGTDL-----------------HM-
------EMKGYKDG-GI-Q---L--QCRSTGWYPQPQVQWRDAKG-EIIPTV--------
--------------------------VAPVVADRVGLYAVAASVIMR-----E--NSGK-
EASC-TIRNSL-LQQ-EKTAR-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FQSA--Q----------------P----WIA-ALAGI-LPV-----SLLLLSGA--
G-----YFLWRQQQEKKTL---------FNEKKREQEMRELAQSTMK-------------
----------------QERS---------RREKLED-E---LKWR---KIQYMA------
----------------------RGE-----------------------------------
------------------------------------------------------------
--------KSP--------------------AYDEWKAALFQAEDVI---L--D-PDTAN
PILL----------LS-----EDLRSLQLAKE----K--QD-L------------PDI--
PERFNWHHCVL-----------GHENFT---SGRHY---WE-VE-V------GDRKEWHI
GVCRRDVE-R---KGW--------------------------------------------
---------------VKMAPENGFWTMGRS--D--------ENDFRALTDP-R-----TK
---------------------------------LTLAEPPE---KVGVFLDYETGEVSFY
NAIDGSH--IYTFLHTSF-S-GPLYPVFRILTLEPT-------ALTIC-PA---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ARST-----G-----SWLSSCLI-----T
LIFLQPPA-------------------------------------------PV-SD-C--
--------K-GDFSKFHVAPLGGTAELLCPLSLWPETVAK-EVRWLRSPHPQ-RSR-AVH
VFRDGKDRDEG----LMPEYKGRTAL-VMDA-REGSV-ALQIRDVRLEDRGPYRCL--IQ
-V-G--NLSREA-TAI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQV----
------------------------------------------------------------
-----------------------------------------------------AAPSSGS
I---S-----S---------------------SA-VALAVI-LPI-----LGLLNMVL--
I-----CLIWKQRKSKEKLLYE--QVMEVE-NLLSDHAKEK-GR----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSVWRRARLHFVAVT---L--D-LNTAH
PKLI----------LS-----EDRRCVRLGDK----R--QP-V------------PDN--
PQRFDFVVSVL-----------GSEY FL---NGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------ITASPANGHWLVRQS----------RENEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVSSKSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEESI
VSKA---------------------------------------------------EGKR-
-HANGDVSLKTNPS---LLTPQVPEL-----M---DLILPLPSDLGPALQGLKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MADFS
---V-------------------FLGFLKQW---------WSS------IFF-THFLL--
--FLQLGE------------------------------------------VD-SDE-FKV
--------L-GPG-ESLMALVGETVEFPCHLSPYQDAEHM-EIRWFQTQV-S---N-VVY
LYQEQQGLSSP----QMMQFRNRTIF-EANDIADGSV-ILHILSVVPSDEGQYGCR--FL
-S-H--NFSGVA-TWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSSGWYPKPKVQWRDHQG-QCLPP-E-------
------S-------------------EA-IVQNAQGLFSLDTSVIVR-----G--GAHS-
KVSC-SIQNPL-LAQ-KKEFV-------LQVA----------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPRT--S----------------P----WKK-AFLGT-LVA-LPLSLAVLTILA--
L-----QYFYKQRCSQEKLKK--------QGEK-DRE-----------------------
------------------RLQTEL----DWRRSEGQ-----AEWR---AAQRYA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PTTAH
PSLE----------VS-----DDLKSVSSR---PGAP--SI-A------------AHG--
PQRFLEQTCVL-----------SRER FC---SG RHY---WE-VH-V------GRRSRWFL
GACLESVE-R--L-GP--------------------------------------------
---------------ARLSPAAGYWVMGLW--N--------SCEYFVLDPQ-R------V
--------------------------------ALALRVPPR---RVGILLDYEAGKLSFF
NASDGTH--IFTFTDTF--S-GSLYAYFRPRAHDGS---EHPDPLTIC-SLP-VRGPHVL
EEN------DSDNWLQ----------------------------PY-EPL----------
-----NSDWASDEA---LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MDTA------AAPHFS-----LPGSLLL-----
LLLLSLRA-------------------------------------------LVSAQ-LTV
--------V-GPA-SPILAMVGENTTLHCHLSPEKNAEDM-EVRWFRSQF-S---A-AVF
VYKGGRERTEE----QMEEYRGRITF-VNKGISRGSV-ALVVHNVTAQENDIYHCH--FQ
-E-G--WSYDKA-ILR------L--V-VA-----GLGSKH-----------------LI-
------EIKAQEDG-SI-W---L--QCISGGWYPEPLTAWRDLYS-EIVPTLK-------
--------------------------EV-SIADADGLFVVTTAVIIR-----D--KSVR-
NVFC-SIKNTL-LGQ-KKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--T----------------P----WMV-SLAVI-LAVFLIF-----MAV--S
I-----CCIKKLRREKKI-LSG--------EKEVEQEEEE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELQW--------------------R-TFLHAA--P---K--N-PNTTH
PELF----------LS-----EDQRSVRQ-------------V------------PDN--
PERFDSQPCVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEVF-----------GNQYRALSSPDR------I
---------------------------------LPLKESLC---WVAIFLDFEAGDVSFY
NMRDRSH--IYTCPHSAF-S-VPVRPFFRIGSDDSP-------I-FIC-PVL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MLDP----AG-SH-----SFHSWEEG------------------GAGTPRSPLGVEELQ
---EAEGGR-PS----------GS-EDMEHGCRP-------------SLLCSLPSL----
LLLAQLPT---WGS---------------------------------------ADE-FLV
--------M-GPS-KPIVAMLGGEATLPCSLVPAMNAEDM-ELRWFHTKF-S---E-AVF
IYRNHQEEYEE----QMPHYAGRTSL-VRDFLTIGEA-AVHIQQVQASDNGRYTCV--FQ
-K-G--GHYAEG-ILE------L--Q-VA-----GLGSAP-----------------QV-
------HIEGPEQD-GV-R---V--VCKASGWFPKPQVQWTDLSG-KKFLE-F-------
------S-------------------EA-HAQDAAGLFSVEAALVVR-----D--SSAG-
SVSC-SVLNPI-LGQ-EKAMA-------VSIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQA--S----------------P----WKA-AFAGI-LTV-----LGLLLFGA--
G-----CFTRREHSAKLQERQ--------KQRMCFGQ-KMEL-VQE--------------
-----------------------------------------------------Q------
------------------------------------------------------------
------------------------------------------------------------
--------------KI-KR------TASIPW-------------SVT---L--N-PDSAH
VNLA----------VS-----PEKKSVTWNY-TG--V-----------------------
--DLDDRYSVL-----------GLEGIM---SGRCY---WE-VE-IRSGE-GC---NWAL
GLCRDHMT-S--T-GW--------------------------------------------
---------------TTQSPDEGFWVVE-C--Y--------YNNYLAWTKS-L-----QA
---------------------------------LSLRKYPR---RVGIFLDYSEGDVSFY
NMTDGSH--IFSFPPASF-S-GTLYPYFMLE-GY-V-------TLSIC-PTE-GGPEGLP
VPLS----K------------------------SP----------LEEAVRPPG-EGLSS
GSGVDGA-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESA------AALRFS-----APRSLLF-----
FALLSCSA-------------------------------------------LLSGQ-FTV
--------V-GPA-DPVLGMVGEDTMFRCHLSPEKDAERM-EVRWFRAQF-S---P-AVF
VYKGGRESREE----QMEEYRGRTTF-VSEHISTGSV-ALVIHNVTAHDHGIYHCY--FQ
-E-G--RSYHEA-ILR------L--M-VA-----GLGSKP-----------------LI-
------EMKGQEDG-GI-R---L--ECTSAGWFPEPHVVWRDPYG-TILPALE-------
--------------------------EA-YAVDAGGLFTVATALPSR-----D--RSVR-
NVSC-SVNSTL-LGQ-EKETV-------IFIP-A--------------------------
------------------------------------------------------------
------------------------------------------------------------
------RE--F----------------P----WTV-GLAVI-LPSL--LFL---SAA--S
I-----CLVRKLHGGKEV-EN---------------EEKEIACKELE-------------
------------------------------------------------TDHVE-------
------------------------------------------------------------
-----------KEKER--Q-----------------------------------------
----IKGKRVGGQVRW--------------------RRTLLHAADVV---L--D-PDTAH
PELF----------LT-----EDQRSVRR--GPSR----QS-V------------PDN--
PERFDCRPCVL-----------GLESFS---SGRHY---WE-VE-V------ENVMVWAV
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GNQYRVLSSPEK------I
---------------------------------LPLKERLR---RVGVFLDYEAGDISFY
NMRDRSH--IYTCPRSPF-C-EPLRPFFRLGSDDSP-------L-IIC-RAF-AGARGVP
VPE--------GGLILHRTGTRHSH-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSLRVS-----PQGTLLF-----
LLFLSAFG-------------------------------------------QLSAQ-FTV
--------V-GPP-EPVLAMVGESSTLRCHLSPEKSAEAM-EVRWFHTHF-S---P-TVL
VYRGGRERPEE----QMQQYCGRTSL-EGAGLGRGHA-VLVIHNVTAHEDGDYRCS--FQ
-E-G--RSYDQA-IVR------L--E-VA-----DLGMKRPL---------------FQ-
------LMKGQEDG-GI-M---L--ECTSAGWYAPC-----------MEPTLE-------
--------------------------EA-YTAGTDSLFTVPLAVIIR-----D--DSVR-
NVFC-SIHNTR-LSC-KVEAG-------IFIP-GSQDP----------------------
------------------------------------------------------------
------------------------------------------------------------
------QQ--T----------------D----WSP-ECWEE-VGALIWAHLVNVLSCLEY
G-----CLSPKAMPCTQS-VGVPHQLL-------------GASGRTW-------------
------------------------------------------------KDKVS-------
------------------------------------------------------------
-----------RGPEAPT------------------------------------------
---------------P--------------------VTLRLPHSHVV---L--D-AATAH
PELF----------LS-----EDRRSVFR--GTRR----QE-V------------PDD--
PERFDLCPCVL-----------GLERFS---SGRHY---WE-VE-V------EGVMAWAV
GVCSADLP-R--K-GE--------------------------------------------
---------------VA--AGGGVWALELF-----------GGQYRPLAAPAL------L
---------------------------------LPLRELLG---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-A-GPLRPFFLLMSNDSP-------L-AVC-PAF-VGAQGVT
VPE--------DGLVLHGAGARRGR-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------KLLYE--QVMEVX-XXXXXXXXXX-XK----------------
---------------------------------LH-------------KAL---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRNELKL-----------KRAAANSGWRRARLHFXXXX---X--X-XXXXX
XXXX----------XX-----XXXXXXXXXXX----X--XX-X------------XXX--
XXXXXXXXXXX-----------XXXXXX---XXXXX---XR-VY-V------GTKTKWIL
GVCSESLS-R--K-GK--------------------------------------------
---------------VTASPANGHWPVRQS----------QGSEFEALTSPQT------P
---------------------------------FRLKQPLR---CVGVFLDYEAGVISFY
NVTDHSH--IFTFTHSF--S-GPLRPFFEPCLHDGG---RNVAPLIIC-SEL-WQSDEPL
VSKP---------------------------------------------------EEKA-
-HANGDAALTLNPS---LLPAAAPEL--PPLG---GMVLPWPSDFGPALQGLKAPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MA------SSL----------AFLLLNFHVS
LFLVQ-------------------------------------------LLTPCSAQ-FSV
--------L-GPS-GPILATVGEDADLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDIAAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSNL-----------------HV-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPKIQWSNDKG-QNIPAV--------
--------------------------EAPVVADGVGLYAVAASVIMR-----G--GSGE-
SVSC-IIRNSV-LRL-EKTAC-------ISIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRSA--Q----------------P----LIA-ALAGT-LPI-----LLLLLGGA--
S-----YFLWRQHKEITAL---------SSEIESEQEMKERGYAATK-------------
----------------QEIS---------LRESLQE-E---LKRR---KI-QYL------
------------------------------------------------------------
------------------------------------------------------------
----TRGKES--------------------------SSETDKSA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDFP
---V-------------------LPDFSQQV-------PLSNN------LFLFTHLLL--
--LLWPGE------------------------------------------VN-SEE-VSV
--------V-GPG-ESILALVGEEVEFSCHLSPYLDAEDM-EIRWFRSRT-S---E-VVH
LYQGRQELYSQ----QMVQFQNRTKL-LKDDIMDGSV-NLQLLGIIPADEGLYGCR--FL
-S-S--NFSREA-VWE------L--E-VA-----GMGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--KCSSSGWYPKPQAQWKDHKG-QCLPP-K-------
------M-------------------EA-IVQDAQGLFNLETSVIVQ-----G--GAHS-
NVSC-SIQNSL-LIQ-KKEFT-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DA
F---LPGT--S----------------P----WKR-AFLGS-LVG-LPFLLAFLLTLA--
L-----YFFQKQRRSQEKLKE--------QAEK-DKG---RL--TEE---L---------
-----------------GKLQTEL----DWRRAEGQ-----AEWR---AAQQYA----VH
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
RSLE----------VS-----EDGKSVSS--CAA-VS--GS-V------------AGD--
QQRFSEQTCVL-----------SCER FS---AG RHY---WE-VY-V------GRRSRWFL
GVCLAAVP-R--L-GP--------------------------------------------
---------------VRLSPASGYWVMGLW--N--------HCEYFVLDPH-R------I
--------------------------------PLTLRVPPR---RVGIFLDWEAGKLSFF
NVSDGSH--IFTFTDTF--S-GTLCAYFRPRAHDGG---EHPDPLTIC-PLP-IRGTQDL
EED------DRDTWLQ----------------------------PY-EPT----------
-----DPTLG-------L------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEM-ASSA-----G-----SWLSGCLI-----P
LVFLRLSV-------------------------------------------HV-SG-R--
--------A-GDAGKFHVALLGGTAELLCPLSLWPGTVPK-EVRWLRSPFPQ-RSQ-AVH
VFRDGKDQDED----LMPEYKGRTVL-VRDA-QEGSV-TLQILDVRLEDQGSYRCL--IQ
-V-G--NLSKED-TVI--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------LQ V----
------------------------------------------------------------
-----------------------------------------------------AAPSVGS
L---S-----P---------------------SA-VALAVI-LPV-----LVLLIMVC--
L-----CLIWKQRRSKEKLLYE--HVTEVD-NLLSDHAKEK-GK----------------
---------------------------------LH-------------KAV---------
------------------------------------------------------------
------------------------------------------------------------
-------KKLRSELKL-----------KRAAANSGWRRARLHFVA VT---L--D-PDTAH
PKLI----------LS-----EDQRCVRLGDR----R--QP-V------------PDN--
PQRFDFVVSIL-----------GSEY FT---TGC HY---WE-VY-V------GDKTKWIL
GVCSESVS-R--K-GK--------------------------------------------
---------------VTASPANGHWLLRQS----------RGNEYEALTSPQT------S
---------------------------------FRLKEPPR---CVGIFLDYEAGVISFY
NVTNKSH--IFTFTHNF--S-GPLRPFFEPCLHDGG---KNTAPLVIC-SEL-HKSEEST
VPKP---------------------------------------------------EGKG-
-HANGDVSLKVNSS---LLPPKAPEL-----K---DIILSLPSDLGPALQELKVPSF---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MKMKVSSFR
---CR---------------------------CIAT-ASLP-G-----------FI--IF
FLDFHIHQ-------------------------------------------LVSAQ-FSV
--------I-GPD-QPVTAIVGEATVLPCHLSPQMSAENM-EVRWIRSQH-S---A-AVH
LYRDGQEQTED----QNPEYQGRTEF-LRDSLTEGNV-SLRIRNIRPSDEGQYRCF--VQ
-S-L--TFYNEA-TLE------L--K-VA-----ALGSEL-----------------QL-
------SVESYQNG-EI-Q---V--VCQSAGWYPEPQVLWRDSSG-QQLPS-L-------
------S-------------------ET--SRAGNGLFEAKTTIVVT-----E--NSNQ-
KLSC-CVWNNL-LNQ-EKGS----T---LSIS-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
F---FPKF--S----------------M----WVV-TLCMI-LLV-----SFVCIGLL--
A-----HLFRMK----EKLAA--------E-L---RW-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------R----------------------------RALTHPAPVT---L--D-PDTAH
PQLI----------LS-----EDGKRVRWGDT----R--QR-L------------LDN--
PKLRTSGV----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MSAENM-AVTWFRSEL-S---P-FVH
HYSDGKDQYGQ----QMPEYQRRTEL-LKDGLSQGNV-TLKILHVRLSDEGRYHCF--VQ
-N-G--LFFEEA-VLE------L--K-VA-----ASGSAP-----------------HV-
------SVEDYQDG-GI-R---V--VCRTAGWYPEPEVMWRDLNG-QAFPS-A-------
------S-------------------QT-NSQEANGLYGAETSAIIM-----E--NSNR-
NLSC-LVRNTH-LSQ-EKEST---L---FYIS-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPKV--N----------------P----WMA-SLGVT-LVV-----LLGSFALS--
V-----YLFRIK----GKCWS--------R-K---YR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------D-----------------------------A---HKGFP---S--K-PRTGT
-------------------------DLTLGLA----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---N---------------------------------SCLL---------AYL-----LT
FMVLQLPT------------------------------------------LDSAAP-FDV
--------I-APQ-EAVLALLGSDVELTCRFSPNASAEHMEELRWFRQTR-S---P-AVL
LYRAGQEQEDQ----QMTEYQGRVTL-VTDGLPDGRA-TLRIRGVRVSDQGEYRCF--FK
-D-KD--YSEEA-SAH------L--K-VT-----ALGSDP-----------------HI-
------SLGVKENG-QI-Q---L--RCTSSGWFPEPEVQWRTPSG-DSLPS-A-------
------A-------------------ES-SSRDAEGLFTVAASVILT-----D--SSVK-
NVSC-CIQNLL-LGQ-EKEVE-------ISVP-APL------------------------
------------------------------------------------------------
------------------------------------------------------------
----VPR-L-T----------------P----WIA-AVAVV-ILT-----LGFLTIGS--
V-----FFTWRLYKERSREQK--------SESGSK-------------------------
-------------------------------ERLLE-EL---RCK---KTALH-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------EVDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-L------------PDR--
PERFDSWPCVL-----------GREI FT---SG RHY---WE-VE-V------GDRTDWAV
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPENGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LPLAAPPR---RVGVFLDYESGDISFY
NMSDGSL--IYAFPSTSF-S-APLRPFFCLWSCG-------KKPLTIC-PTA-KGPEKIT
VIAN----V------------------------QD-----------TVPLS---PLGEGS
ASGEADT---LHSK---LIPFSPSQV--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
-----PEEFTVIGPQQP-IVAFVGTEVTLPCHLHPQLDATYMEVVWFHGQHSNVV-HRYK
YAQDYLKYQHPDYRGRTEFLRE-NISHGSVALRLHQIRPSDEGKYRCFFESPSHYNEAEF
QLKVIGECAKGIKVGG---------L----GV---------------------------K
GVWSLENSSVHS----------------------------NVM-----------------
---KSKSLNE--------------------------------------------------
---PSFNYLLNQ----------------------------------FDNFYL--------
---LGPRHK------------------------------DH--CLLFH-LYWSTAS-FTV
--------I-GPQ-QPIVALVGTEVTLPCYLHPQWDATYM-EVIWFHGQN-S---S-LVH
HYKNAQEFLKY----QHLDYRGRTEF-LRENIYHGSV-ALRLHQIRPSDEGKYRCF--FE
-S---PSHYHEA-EFQ------V--N-VT-----GIGSAP-----------------HI-
------YIDGVGYK-RL-H---L--VCTSTGWYPEPEVQWKNHKE-EPLSGGS-------
--------------------------VT--MKKVNGLFSVETSITVS-----A--NSKE-
NVSC-VIGSPH-QSQ-KKEAH-------IAWS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VKMA------SSL----------AFLLLNFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSSL-R---Q-VVN
VYADGKEVEDR----QSAPYRGRTSI-LRDDITAGKA-ALRIHNVTASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNDKG-EDIPAV--------
--------------------------KATVIADGVGLYAIAASVIMR-----G--SSGK-
GVSC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIT-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMEYAATK-------------
----------------QEIR---------EKTCSER-R---MEWR---KNKTTD------
------------------------------------------------------------
------------------------------------------------------------
----LFLICVS--------------------FLSEWKMALFKPADVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PIP-KQVESSP
-N--P--D-----------------------LVPD--------HSLETPVA------PDL
ANESGEPQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAVSP
---N---------------------------------PFLL---------ACL-----LT
LLVLQLPT------------------------------------------LDS-AP-LDA
--------I-APQ-EPVLALVGSDVELTCRFSTNASAEHMEELRWFRQTR-S---P-AVL
LYRAGQEQKGQ----QMTEYRGRASL-VTDGLPGGHV-TLRIRGVRISDQGEYRCS--FK
-D-ND--NSEEA-ATH------L--K-VA-----ALGSDP-----------------HI-
------SMEVKENG-QI-Q---L--ECTSSGWFPEPEVQWRTPSG-DRLPF-T-------
------A-------------------ES-KNHDEEGLFTVAASVIIT-----D--SSIK-
NVSC-CIQNLL-LGQ-EKELE-------ISIP-APF------------------------
------------------------------------------------------------
------------------------------------------------------------
----TPR-L-T----------------P----WIV-AVAII-ILA-----LAFLTIGS--
V-----FFTWRLYKERSRGQR--------SEFGSK-------------------------
-------------------------------ERLLE-EL---S-------KLP-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SFDVT---L--D-PDTAH
PHLF----------LY-----EDSKSVRLEDS----R--QI-V------------PDR--
PERFDSWPCVL-----------GRET FT---SG RHY---WE-VE-V------GDRTDWAI
GVCRENVV-K--K-GF--------------------------------------------
---------------DPMTPDNGFWAVELY-----------GNGYWALTPL-R-----TP
---------------------------------LRLAGPPR---RVGVFLDYESGDISFY
NMSDGTL--IYTFPSTSF-S-GPLRPFFCLWSCG-------KKPLTIC-PAA-NAPEKVT
VIAN----V------------------------QD-----------TIPLS---PLGEGS
ASGETDT---LHSK---LIPFPPRQV--AP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------TSVRAC-----SVASLPF-----
FLVLSLDV-------------------------------------------LASAQ-FTV
--------M-GPA-EPVLAMVGENTTLHCHLSPERNAEDM-EVRWFRWHF-S---P-AVL
VYRSHQEREEE----QMAVYQGRTTF-MSTDISKGRV-ALIIHNVTAYDNGIYCCY--FQ
-E-G--RSYDQA-ILR------L--M-VA-----SLGSKP-----------------LI-
------KMKTLEDG-SI-L---L--ECTSEGWYPKPRAVWRDPYY-EAVPALE-------
--------------------------EE-CTAYRGGLFTVTMTVIIR-----D--CSVR-
NMTC-SINNTL-LNQ-EMESV-------IFIP-ESFVS----------------------
------------------------------------------------------------
------------------------------------------------------------
------SP--P----------------L----WMV-AMAVI-LPVLMLILL---TSG--S
I-----CLVKKHHRKKSI-LP---------------SEKEVEYEE---------------
------------------------------------------------------------
------------------------------------------------------------
------------------K-----------------------------------------
----ETSRQLQEELRW--------------------RRTLLHVADVV---L--D-PDTAH
PELF----------LS-----DDQRSVRR--GASR----QS-L------------PDN--
PERFDCRPCVL-----------GQES FS---SG KHY---WE-VE-V------ENVMVWAI
GVCRDSVE-R--K-GE--------------------------------------------
---------------ALLVPQNGFWTLEMF-----------GNQYRALSSPET------I
---------------------------------IPLKERLH---RVAIFLDCEAGDVSFY
NMRDRSH--IYTCPPVAF-D-GPLRPFFRLGSDDSP-------L-FIC-PAF-TGAQGVT
IPE--------GGLILYRTRPVSQSHVKKP------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
-------M-------------------------------------------CFTAE-FTV
--------M-GPA-HPVTAAVGEAIELPCHLSPRMSAENM-EVRWFRSEF-L---S-FVH
LYQRGKDEYKE----QMPDYQGRTEL-LKAGLSEGNV-SLRILNIRPTDRGQYRCF--VQ
-D-G--TLYEEA-LLE------L--K-VA-----VLGSSP-----------------LI-
------SVQGHQDG-GI-R---V--VCQSAGWYPEPEVLWRDHIG-HLLTS-L-------
------S-------------------EA-KSQVDNDLFETENSIIMR-----E--QANQ-
SLSC-CIRNTF-LNQ-EKES----T---IYIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRV--N----------------P----WMV-CLSVI-LPV-----LFGFMGLT--
A-----YLFKIK----GKY-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------KGRTGP--YI
CVFLD---LKM--------------------------------------YDLLNGK-FTV
--------I-GPH-EPIIALVGREVTLPCYLHPKLDAQNM-EVVWFHGQN-S---S-LVY
HYKHAWDYLKY----QHQDYQGRTEF-LQENITSGNV-SLRIHHIRPSDEGKYRCF--FE
-S-S--SYYHEA-EFQ------V--Y-VA-----GECSAP-----------------HI-
------YKESAGNK-RL-Y---L--VCTSTGWYPEPEVQWKNHQE-EPLSG-G-------
------S-------------------VT-M-KKVNGLFSVEMSIIVS-----A--NSKE-
NVSC-VIGILH-FSQ-KMEAS-------FNLA-G--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MESA------AALHFS-----RPASLLLL---L
LLLLSLCA-------------------------------------------LVSAQ-FIV
--------V-GPT-DPILATVGENTTLHCHLSPEKNAEDM-EVRWFRSQF-S---P-AVF
VYKGGRERTEE----QMEEYRGRTTF-VSKDISRGSV-ALVIHNITAQENGTYRCY--FQ
-E-G--RSYDEA-ILH------L--V-VA-----GLGSKP-----------------LI-
------SMRGHEDG-GI-R---L--ECISRGWYPKPLTVWRDPYG-GVVPALK-------
--------------------------EV-SMPDADGLFMVTTAVIIR-----D--KSVR-
NMSC-SINNTL-LGQ-KKESV-------IFIP-ESFMP-------SVSPCAVALPI----
------------------------------------------------------------
------------------------------------------------------------
----I-------------------------------------VVILMIP-----IAI--C
I-----YWINKLQKEKKI-LSG--------EKEFERETREIAVKELE-------------
------------------------------------------------KERVQ-------
------------------------------------------------------------
-----------KEE----EL----------------------------------------
-QV---KEKLQEELRW--------------------RRTFLHAVDVV---L--D-PDTAH
PDLF----------LS-----EDRRSVRR--CPFR-HLEES-V------------PDN--
PERFDSQPCVL-----------GRES FA---SG KHY---WE-VE-V------ENVIEWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------VLLIPQNGFWTLEMH-----------KGQYRAVSSPDR------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSAF-S-VPVRPFFRLGCEDSP-------I-FIC-PAL-AGANGVT
VPE--------EGLTLHRVGTHQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DV
F---LPGT--S----------------P----WKR-AFLGT-LVG-LPLLLALLMMLV--
L-----YFFRKQRKSQEKLKK--------QAER-D-K---G-KLTVE---L---------
-----------------GKLQVEL----DWRRAEGQ-----AEWR---AAQRHA----VD
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PGSAH
PSLE----------VS-----EDGKSVSSL---RTAP--GS---------------EN--
PQWLSEQTCVL-----------SRELFS---TGRHY---WE-VH-V------GRRSRWFL
GVCLAAVP-R--A-GH--------------------------------------------
---------------ARMSPATGYWVMGLW--N--------SCEYFVLDQH-R------V
--------------------------------PLSVRVPPR---CVGIFLDIEAGKLSFF
NVSDGSH--IFTFTDTF--P-GMLCAYFRPRAHDGS---EHPDPLTIC-PLP-VGEKHVL
EEE------DSDAWLQ----------------------------PY-ESS----------
-----NTDLG-------L------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVDLP
---V-------------------FPDSCQRG-------PLPSS------VFFLTHLFL--
--LLQPGK------------------------------------------LNSEEE-VRV
--------V-GPG-EPILALVGEDVEFSCHLSPYLDAEDM-EIRWFRSQI-S---D-VVH
LYQGRQELYSQ----QMAQFQNRTKL-IKDYIIDGSV-NLWLHGVIPADEGLYGCR--FL
-S-S--SFSKEA-IWE------L--E-VA-----GLGSDP-----------------RI-
------SLEGFNKG-GV-Q---L--RCSSSGWYPKPQAQWKDHKG-QCLSP-E-------
------T-------------------ET-IVQDAQGLFNLEISVLVQ-----G--DVHS-
NVSC-SIQNSL-LLQ-KKEFT-------IQIA----------------------------
------------------------------------------------------------
----------------------------------------------------------DA
F---LPGG--S----------------P----WKR-AFLGT-LVA-LPLLLALLMTLA--
L-----YFFQKQRQCQEKLRK--------HAEK-DKE---RL--TAE---L---------
-----------------GKLQTEL----DWRRAEGQ-----AEWR---AAQQYA----VN
V-----------------------------------------------------------
------------------------------------------------------------
----------------------------------------------T---L--D-PASAH
RSLE----------VS-----QDGKSVSS--CRA-EL--NP-V------------VGD--
PQRFSEQTCVL-----------SYQRFS---AGRHY---WE-VH-V------GRRSRWFL
GVCLASVP-R--T-GQ--------------------------------------------
---------------VHLSPANGYWVLGLW--N--------RCEYFILDPH-R------I
--------------------------------ALTLRVPPR---RVGIFLDWEAGKLSFF
NVSDGSH--IFTFTDTF--S-ETLCAYFRPRSHDGS---EHPDPLTIC-PLP-VRRTCNL
EED------ELDTWLQ----------------------------PY-EPS----------
-----DPTLG-------LW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MKMA-SSLDFP-----LLH---LF--VC
LILVQLLT-------------------------------------------PCSAQ-FSV
--------I-GPP-GPILAMVGEDTDLPCHLSLKMSAETM-ELMWVRSSL-R---E-VVY
EYANEKEVEDQ----QMAEYRGRTSI-LRDGITEGKA-TLRIYGVRVSDSGNYLCY--FQ
-D-E--NFYEKA-MVE------L--K-VA-----ALGSDC-----------------HI-
------EMKGHEDG-GI-R---L--DCMSAGWYPRPEIQWIDAKG-TDMPA-V-------
------P-------------------GP-LELDGADLYAVAASVIVK-----D--DSED-
EVSC-IIRNPL-LRQ-EKSAR-------ISIA-D--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FWRA--R----------------P----WII-PRGQT-PIS-----LFLRTRGA--
------CSGWTDDRICQTTVR--------D-L----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------I-------------------RITLCLAAR-----------ASH
----------------------------QGDI----S--GR-W------------R----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGPA------AAPHFS-----LPASLLL-----
-HLLSLCA-------------------------------------------LVSAQ-FTV
--------V-GPA-SPILAMVGENTALRCHLSPEKNAEDM-EVQWFRSQF-F---P-AVF
VYKGGRERTEE----QMEEYRGRVTF-VSKGISRGSM-ALVEHSVTAQENGIYRCY--FQ
-E-G--RSYDEA-ILR------L--V-VA-----GLGSKA-----------------LI-
------EIKAQEDG-SI-W---L--ECISGGWYPEPLTVWRNPYS-EIVPTLK-------
--------------------------EV-SIADAEALFVVTTAVIIR-----D--KSVR-
NVSC-SIKNTL-LRP-EKETV-------VFIP-ESFMP-------STSPWMVALAV----
------------------------------------------------------------
------------------------------------------------------------
----ILTT--F----------------P----WMV-SMAVI-LAVFIIF-----MAV--S
T-----CCIKKLQREKKI-LSG--------EKEVEQEEKE--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----IAQQLQEELAH--------------------GPFLFADV--V---L--D-PDTTH
PELF----------LS-----EDQRSVRR-------------V------------PDN--
PERFDSQPHVL-----------GWES FA---SG KHD---WE-VE-V------ENVMVWTV
GVCGDSVE-R--K-GE--------------------------------------------
---------------VLLLPQNGFWTLEMF-----------GNQYWALSSPDR------I
---------------------------------LPLKESLC---HVGVFLDYEAGDVSFY
NMRDRWH--VYTCPHSAF-S-VPVRPFFRLRSDESP-------V-FIC-PAL-TGASGVT
VPD--------EGLTLHRVGTQQSL-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MGAT---G---VLA--------THC------VI
LCFLH-KE------------------------------------------ALSSEQ-FTV
--------T-GLQ-RPVLASLGGNVDLSCQLSPPQQAQHM-EIRWFRNRY-T---E-PVH
LYRNGKDLHGE----TISKYVERTEL-LKDAIGEGKV-TLRIFKLTADDDGSYHCV--FK
-V-G--EFYEEH-ITE------V--K-VT-----ATSSDI-----------------QI-
------LMHPPNIK-GV-M---L--ECHSGGWFPQPHMEWRDSKG-KVIPA-A-------
------S-------------------KS-HSQDENKLFNMTMTLLIE-----A--SSYR-
NVTC-YLQNRL-THQ-EENIS-------IVLS-GKSCV-------SSSVTIIVTYTY--Y
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MAF--MF
ILVLSFY-------------------------------------------KLVSGQ-WQV
--------K-GPD-KFVQALVGQDAVFSCSLFPETSAKTM-EVRFFKNQL-H---A-VVH
LYRDGKDLEPM----QMPQYQGRTEL-VKDFIAWGIV-SLRLKNITPSDIGLYVCW--FS
SP----VYDEELETWSLLSSFPV--F-FP-----GWGSLP-----------------LI-
------SMVGYVDG-GI-Q---L--LCLSSGWFPQPIVKWKGPQG-QNLSSDS-------
---------------------------R-ANADEHSLFDVETSLIIQ-----E--S-TG-
SISC-SIHLAE-QSH-EVESK-------VLIR-ETFFQP---------------------
------------------------------------------------------------
------------------------------------------------------------
----------S----------------P----WRL-ASILLGLVC---GGLCAIILGM--
-----TIVFFKSKEA---WFF--------MV-----------------------------
-------------------------------------------------PVA--------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------LTSGLTYASSLPHLT---L--D-PETAH
PQFC----------VS-----D-LKTVTHRRS----P--QE-V------------PYS--
EKRFA-RKSVV-----------ASQG FQ---AG KHY---WE-GD-V------GYNKWWYI
GVCRDDVD-R--K-ETC-------------------------------------------
---------------ATLSPNNGYWVFRLM--R--------EHLYSTFNPH-V-----IT
---------------------------------LNPRTPPT---RVGVFLDCEGGTISFF
NINDQSL--I-CCLTCQFEG-L-LRPYIQHEIYV-E---ENGTPLFLC-PVP-WG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MKMA------SSL----------AFLLLNFRVC
LLLVQ-------------------------------------------LLTPCSAQ-FAV
--------L-GPH-GPILAMVGEDVDLPCHLFPTMSAETM-ELRWVSSNL-R---Q-VVN
VYADGKEVEDR----QSAAYRGRTSI-LRDDITAGKAAALRIHNITASDSGKYLCY--FQ
-D-G--DFYEKA-LVE------L--K-VA-----ALGSDL-----------------HI-
------EVKGYEDG-GI-H---L--ECRSTGWYPQPQIQWSNTKG-EDIPAV--------
--------------------------KAPVVADGVGLYAIAASVIMR-----G--SSGK-
GISC-IIRNSL-LGL-EKTAS-------ISIT----------------------------
------------------------------------------------------------
----------------------------------------------------------DP
F---FRNA--Q----------------P----WIA-ALAGT-LPI-----SLLLLAGA--
S-----YFLWRQQKEKIAL---------SRETEREREMKEMACAATK-------------
----------------QEIS---------LRGI--------QKWR---KIQ---------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------YMAPDVI---L--D-PDTAN
AILL----------VS-----EDQRSVQRAEE----P--RD-L------------PDN--
PERFEWRYCVL-----------GREN FT---SG RHF---WE-VE-V------GDRKEWHI
GVCSKNVE-R--KKGW--------------------------------------------
---------------VKMTPENGYWTMGLT--D--------GNKYRALTDP-R-----TN
---------------------------------LKLPEPPR---KVGIFLDYETGEISFY
NATDGSH--IYTFPHTSF-S-EPLYPVFRILTLEPT-------ALTIC-PTP-KQVESSP
-D--P--D-----------------------LVPD--------HSLETPVA------QGL
ANESGEPQAEATSL---LLPAHPGV-DGLPLH--------N-NQSEP-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------GHLVAIVGGQAELSCHLFPPQSAKHM-EVCWFKGDR-S---K-LVH
LYRGGQEVNEE----AAPEYVDRTEF-VKEAIGEGRL-TLRLHNISVSDDGPYQCS--FK
-D-S--DFHGVA-SMN------L--S-VA-----ALGLET-----------------QI-
------HIKTPSAD-GL-M---V--ECKSGGWFPQPQMEWRDNNG-EVVPP-S-------
------S-------------------KS-YSQDGAKLFHIEMTLLLR-----N--RSQG-
NMTC-YIRNPL-IGE-GKQTN-------IIIV-GEYS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------L-LGALQVSVS-------------LPP---PCV----
SLGFLSPM---SVS---------------------------------------TEE-FMV
--------I-GPS-KPIVAVLGADVMLPCLVSPAMDVENM-ELRWFHSKF-S---E-AVF
IYQNQREQREE----QLAQYRGRTSL-VKDFLFQGEA-AVRIHNVQAFDNGLYTCF--FR
-M-G--IFHEEA-SVE------L--K-VA-----GVGSAP-----------------QV-
------HITGPEED-GV-R---V--VCMASGWFPKPQVQWRALSG-EKFLM-F-------
------S-------------------ET-QAQDGEGLFTIETTLVMR-----D--SSSG-
NVTC-SVLNPI-LSQ-EKAMA-------IFIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------P
F---FPQS--S----------------P----WKP-VFMVI-LTV-----LMLPILGD--
A-----FYIMREHTSKLQETQ--------EWKKLHRD-KEEIQQIKEEA-LKAR------
------------DE-LQ----ADLD-----WRKSVY--L--VG-----------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------SVS---L--D-PESAH
SSLD----------VS-----DDKTTMTLKDSTK--Y-----------------------
--TEFGFYSIL-----------GHEGIT---SGCCY---WE-VE-IRNAD-KS---EWAL
GVCRRDVE-R--K-GW--------------------------------------------
---------------YRECPGKGFWVVG-M--Y--------GYTFSS--LPDN------S
---------------------------------ELLVPVSQ---RVGVFLDLKEGDVSFY
NMTDGSH--IFSFPLASS-S-GTLFPYFRLRSGD-V-------SLTIC-SGV-GG-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEPA------AALPFS-----LPASLLL-----
-LLLSLCA-------------------------------------------LVSAQ-LTV
--------V-GPT-DPILAMVGENTTLRCHLSPEKNAEDM-EVRWFRSHF-S---P-AVF
VYKGRRERTEE----QMEEYRGRTTF-VSKDVSRGSV-ALVIHNVTAQENGTYRCY--FQ
-E-G--RSSDEA-ILR------L--V-VA-----GLGSEP-----------------LI-
------EMRGHEDG-GI-L---V--ECISRGWYPKPLVLWRDPSG-EVVPALK-------
--------------------------EV-STHDADGLFMVTTAVIIR-----D--RSVR-
NMSC-SVNNTL-LGR-KKESV-------IFIP-ESFMP-------SVSPCVVALPV----
------------------------------------------------------------
------------------------------------------------------------
----TL-------------------------------------LVLMIP-----IAV--C
I-----YWINKLQREKRIL-LG--------EKEFEREMREIATKDLE-------------
------------------------------------------------KERVE-------
------------------------------------------------------------
-----------KE----TEL----------------------------------------
-QI---KEQLQEELRW--------------------RRTFLHAADVV---L--D-PDTAH
PELF----------LS-----EDRRSVRR--GPFR----QS-V------------QDN--
PERFDSQLCVL-----------GRES FA---SG KHY---WE-VE-V------ENVMVWTV
GVCRDSVE-R--K-GE--------------------------------------------
---------------FLLLPENGFWTLEMF-----------GNQYRALSSPER------I
---------------------------------LPLKESLC---RVGVFLDYEAGDVSFY
NMRDRSH--IYTCPRSVF-S-RPMRPFFRLGSDDSP-------I-FIC-PAL-TGADGVT
VPE--------AGLTLHRAGTHHSPQ----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------PTMV------RSL----------AFHLLHLTVC
LPLVQ-------------------------------------------LLTPCSAQ-VAV
--------I-GPP-EPILAMVGEDAELLCYLSPKMSAETM-ELMWRRSGL-K---Q-VVR
AYAHGMEE--T----EIAEYRGRTSI-LRGDIAEGKA-VLRIHKVRASDSGTYQCY--FQ
-D-D--DFLAKA-QVE------L--K-VA-----ALGSDL-----------------HV-
------EMKGYEDG-GI-R---V--ECTSAGWYPQPHVEWRGEGG-ESLPAM--------
--------------------------AAPGAADGEGLYAVTSSVILK-----G--GSGK-
GVSC-VVRNPL-LSQ-EKTAM-------VSIA----------------------------
------------------------------------------------------------
----------------------------------------------------------GP
F---FSST--K----------------P----WQA-AFGVI-LVA-----LLGLLAGL--
V-----MSWRQQQKRIRAL---------SQEKERERAEKEAALVAKE-------------
----------------HER------------EKLQE-E---LRWR---KQQYLE------
----------------------PGD-----------------------------------
------------------------------------------------------------
--------RSQ--------------------AYAEWKMALYQPADVI---L--D-PDTTH
PNLF----------IS-----EDQRSLNCTLE----R--QR-L------------PDN--
PKRFQDRYCVL-----------GCESFT---SGRHF---WE-VE-V------GDRKEWHL
GVCREIVE-R---KYY--------------------------------------------
---------------ATITPENGFWTIVLL--G--------GHEFQARTDP-R-----SK
---------------------------------LTVVNRLK---RVGVFLDYERGEVSFY
DAINGSH--IFTFPQASF-S-GPLRPFFRIWSHEPT-------ALTIC-PAL-RGVGSSL
----L--PD----------------------PLPD--------PSLETPVA------SGS
ADGNADSQEEVMSL---LLSAQP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------T-RTEP-D------LKELACL--FP
LLCNYIPQ-------------------------------------------VPPRA-FQV
--------Q-GPH-DPLVAMLGGEAELPCFLSPPQRIKNM-KITWTRSLP-S---R-VVH
LYEDGRDKPEE----AMAEYLGRTEL-VKNVMHKGIV-VLKILNVQPSDNGQYRCV--IQ
-H-G--SFYSDT-MIE------L--K-VA-----ALGSHP-----------------QF-
------HVAVTRSG-QL-R---L--ECTSEGCFPQPKVQWMDSEG-REIPA-E-------
------S-------------------ET-HTQDKCGLFHVTTSLLLR-----E--TSQK-
NLTC-SVWNPV-LNQ-KKSTP-------ILLP-G--------------------------
------------------------------------------------------------
-----------------------------------------------------------A
N---FP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MVGLP
---GSLDSA--------------HLDSSQPE-------SLPCS------LFFMLL-----
LLLPRPGE------------------------------------------LN-TEE-VTV
--------V-GPG-EPVLALVGEEVEFPCHLSPYLDAAHM-EIRWVRGRA-A---D-VVH
VYGAGAR--QE----QTARFRNRTRL-LTDDIADGSV-VLQLRDVVPADEGLYGCR--FL
-A-G--GFSGEA-VWE------L--E-VA-----GLGSDP-----------------HI-
------SLEGFKEG-GI-Q---L--RCSSHGWYPKPKVQWRDHQG-QCLPP-E-------
------S-------------------EA-IVQDAQGLFRLETSVVVQ-----G--GVHS-
NVSF-SIQNVL-LSQ-KKEFV-------VQIA-GQWGPAHTCLLVAMLS-----------
------------------------------MLDPLAVWAAAGGRW---------------
---------------------------------------GQMRGVRP--KTRGSRRADLL
S---SLTA--P----------------D----WRR-AEGQA-GEW---------------
-------------LGAPPLLP--------PRA----------------------------
-----------------------------RA-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------SS
------------------------------------PSEPT-P------------L----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MVNSLDS----------------SLLRDF--FS
ILLLQVSM---WGS----------------------------------------DS-FLV
--------I-GPS-EPIVAMLGTDTVLPCRVSPALNLESM-ELRWFRSQF-S---E-AVY
VYRNGMEQAGE----QLVDFKGRAEL-VKDYITEGRV-AVRIYSLRISDNGMYKCF--FK
-K-D--SDFEVA-TLE------L--K-VI-----GLGSGP-----------------HV-
------FMVGPEDK-GI-R---L--TCRGKGWFPQPEVQWTDARG-EKIPS-L-------
------S-------------------ED-ETQDDDGLFQIEASLIVR-----D--SSKT-
EVSC-SMKNP F-FGQ-GQVET-------ISIP-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRT--S----------------P----WKI-AFAGT-FLI-----LGGFVVAV--
M-----FLAWKQQQEKRRVWE--------V----QKE-KKEESKAKE-------------
------------------LLEKELV-----KRKQL---YQ-QDWR---KAKLY-------
------------------------------------------------------------
------------------------------------------------------------
-------------ADW-RK------GQFKVA-------------A IT---L--D-PDSAH
PNLI----------LS-----ENRKQVSLMENVP--Q-NCD-A------------SVCQG
QEECEAVFSVL-----------GRNCFN---T GRHY---WE-VQ-VNMGTVAGPVNKWAV
GVCSNTVR-R--E-GW--------------------------------------------
---------------FVEGPEKNIWVVA-Y--E--------KGEVKFP-TSP------ES
---------------------------------LSLKQHPQ---RIGVFLDWEDGDVSFY
NMADGSH--ICSFTGLTF-Y-ETLCPYFSLRGTG-T-------SVTIC-SGL-DYTENCP
DSSP----NTSVTHLR--------------------------------------------
-SC-DTGAPQEAKP---LL-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGCSLSGA---VASFLFIL
LTMKQSEDFRVIGPAHP-ILARVREDVLLTCQLLPKRTAMHMEVRWYRSEPSTPV-FAHR
DGVEVTEMQMEEYRGRVEWIEN-DIAKGSVA-KTQNIQPSDNGQYWCHFQ VGNYCGETSL
LLKVARLGSAPNIHME---------GP---GE---------------------------S
GVQLVCTTRGWF----------PEPQ---VY---WEDIQGEKL-----------------
-LAVSERHIQDED--------------------------------G------------LF
YVEATPVVRNAS----------------------------------AESVSCFVHN----
PVLTEEKG------------------------------SVI--SLPEK-LQTELAS-LKV
--------I-GPS-QAILVRVGEDIQLTCYLSPKANAQSV-EVRWVRSHC-Y---P-VVH
VYMDGDHVAGE----QTAEYRGRPVL-VSDAIDEGRL-TLQILSARPLDDGQYRCL--FE
-K---DDVYQEA-SLD------L--K-VV-----GLGSSP-----------------LI-
------TVEGQEDG-EM-Q---L--MCSSDGWFPQPHVQWRDMEG-KMIPSSS-------
--------------------------EA-LTQGSHGLFHVETLLRVT-----D--ISAV-
DVTC-SISIPF-LGE-EKITT-------FSLS-GW-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------VR-ATPS----PVS------ALGPLA-----
-----KCLSAK--------------------------------------LSRPLGQ-FMV
--------T-GPT-QAVIAPVGGEVTLACHLTPKMDARTM-FVTWHRIDT-G---I-VVH
RYLGNQGQEEV----EGPGYERRTQF-RKEDIINGNV-SLKILRVRPSDEGTYKCS--FQ
-S-L--SSVDEA-QFS------I--R-VA-----VLGSQL-----------------QI-
------RMAGQEGD-GI-R---L--VCSSSGWFPEPRLWWTDHRG-QERPP-L-------
------A-------------------ES-KSRDRSGLFRTEGSLLVT-----D--RSTS-
AVSC-SVWNPV-LDR-GKVAE-------VSVA-E--------------------------
------------------------------------------------------------
-----------------------------------------------------------S
F---FPRV--S----------------P----VLV-ALAVI-LSL-----LGLLLIGS--
A-----YVIWAQRRK-IS--K---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

-------------------------------------MVDFPGYSLSGA---VASFFLVL
LTMRQPENWRVIGPTHP-ILARIGEDALLTCQLLPKRTAMHMKVTWYRSEPSTPV-FAHW
DGADVTEMQMEEYRGRVEVIKD-GILEGKVTLKINNIQPSDNGEYWCCIQENNYCQETSL
Q LKVTGLGSAPYIHME---------AP---VE---------------------------S
RIQLVCTAKGWF----------PEPQ---VY---WEDITGEKL-----------------
-LAASEHLIQYEN--------------------------------G------------LF
YVEATLVVRNDS----------------------------------VENVSCLIHN----
PIL NEKKS------------------------------SVI--SIPEK-FQNELAS-LKV
--------I-GPS-QPILVRVGEDIQLTCYLSPETNAQSM-EVRWIQSHR-Y---P-AVY
VYADGEHVTEE----QMSEYRGRTVL-VNDAAEEGRL-TLQIHNATVSDDGQYRCL--FE
-K---DGVYQEA-SFD------L--K-VV-----GLGSSP-----------------QI-
------TIKEQKDG-EI-E---L--ICSSEGWFPEPHVKWKDMEG-KIIPAFS-------
--------------------------EV-MTEGSHGLFHVETSLLVT-----N--SSIV-
NVTC-TISNPH-LDE-EKMAN-------FSLS-EPMM-----------------------
------------------------------------------------------------
-----------------------------------------------------------N
F---------S---------------------WKIVLILVL-LLAA-----------L--
V-----GLVKRKSCEKGSPDN--------F-PTPRRFCN---------------------
---------------------------------ISKG-K--K------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-

Query Results

"ENSGT00760000118933_0"

ENSGT00760000118933_0